Mitch Report

date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     x
## 5_8S_rRNA  12.9204273
## 7SK         1.4582210
## A1BG        2.1192797
## A1BG-AS1    6.5771976
## A1CF       -0.2475616
## A2M       -10.7739590

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2512
num_genes_in_profile	26741
duplicated_genes_present	0
num_profile_genes_in_sets	9101
num_profile_genes_not_in_sets	17640

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2512
num_genesets_excluded	1029
num_genesets_included	1483

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
CLEC7A (Dectin-1) induces NFAT activation	11	1.73e-06	-0.833	8.11e-06
Establishment of Sister Chromatid Cohesion	11	2.26e-06	-0.823	1.02e-05
Cohesin Loading onto Chromatin	10	7.27e-06	-0.819	2.94e-05
ERKs are inactivated	13	4.28e-07	-0.810	2.27e-06
S33 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808	3.91e-07
S37 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808	3.91e-07
S45 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808	3.91e-07
Signaling by CTNNB1 phospho-site mutants	15	5.89e-08	-0.808	3.91e-07
Signaling by GSK3beta mutants	15	5.89e-08	-0.808	3.91e-07
T41 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808	3.91e-07
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.76e-07	-0.806	1.07e-06
APC truncation mutants have impaired AXIN binding	14	2.29e-07	-0.798	1.33e-06
AXIN missense mutants destabilize the destruction complex	14	2.29e-07	-0.798	1.33e-06
Signaling by AMER1 mutants	14	2.29e-07	-0.798	1.33e-06
Signaling by APC mutants	14	2.29e-07	-0.798	1.33e-06
Signaling by AXIN mutants	14	2.29e-07	-0.798	1.33e-06
Truncations of AMER1 destabilize the destruction complex	14	2.29e-07	-0.798	1.33e-06
Signaling by Hippo	20	7.94e-10	-0.794	7.32e-09
MET activates RAP1 and RAC1	11	5.41e-06	-0.792	2.27e-05
MAPK3 (ERK1) activation	10	2.78e-05	-0.765	1.00e-04
RAF-independent MAPK1/3 activation	23	2.16e-10	-0.764	2.17e-09
Interleukin-6 signaling	11	1.18e-05	-0.763	4.54e-05
Beta-catenin phosphorylation cascade	17	5.52e-08	-0.761	3.83e-07
Mitotic Telophase/Cytokinesis	13	2.05e-06	-0.760	9.40e-06
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	5.85e-11	-0.756	6.52e-10
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	7.20e-06	-0.719	2.92e-05
Defective EXT2 causes exostoses 2	13	7.20e-06	-0.719	2.92e-05
Synthesis of PIPs at the early endosome membrane	16	1.38e-06	-0.697	6.58e-06
Signaling by PDGFRA extracellular domain mutants	12	3.55e-05	-0.689	1.24e-04
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.55e-05	-0.689	1.24e-04
Activation of RAC1	13	1.72e-05	-0.688	6.43e-05
Synthesis of PIPs at the late endosome membrane	11	8.35e-05	-0.685	2.69e-04
Signal transduction by L1	21	5.62e-08	-0.684	3.86e-07
ALK mutants bind TKIs	12	4.26e-05	-0.682	1.46e-04
FOXO-mediated transcription of cell cycle genes	16	5.18e-06	-0.658	2.18e-05
Syndecan interactions	20	5.15e-07	-0.648	2.70e-06
Prolonged ERK activation events	14	2.87e-05	-0.646	1.03e-04
CTLA4 inhibitory signaling	17	4.47e-06	-0.643	1.92e-05
Gastrin-CREB signalling pathway via PKC and MAPK	17	4.75e-06	-0.641	2.02e-05
Cell-extracellular matrix interactions	16	9.64e-06	-0.639	3.82e-05
Regulation of gene expression by Hypoxia-inducible Factor	11	2.44e-04	-0.639	7.14e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.95e-16	-0.634	9.46e-15
Signaling by WNT in cancer	32	5.49e-10	-0.633	5.19e-09
Processing and activation of SUMO	10	5.34e-04	-0.632	1.43e-03
ERK/MAPK targets	22	2.85e-07	-0.632	1.59e-06
Frs2-mediated activation	12	1.60e-04	-0.629	4.86e-04
STAT5 activation downstream of FLT3 ITD mutants	10	5.78e-04	-0.628	1.53e-03
Signaling by PDGFR in disease	20	1.17e-06	-0.628	5.65e-06
Citric acid cycle (TCA cycle)	22	3.63e-07	-0.626	1.96e-06
Signaling by Activin	15	2.67e-05	-0.626	9.65e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
CLEC7A (Dectin-1) induces NFAT activation	11	1.73e-06	-0.833000	8.11e-06
Establishment of Sister Chromatid Cohesion	11	2.26e-06	-0.823000	1.02e-05
Cohesin Loading onto Chromatin	10	7.27e-06	-0.819000	2.94e-05
ERKs are inactivated	13	4.28e-07	-0.810000	2.27e-06
S33 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808000	3.91e-07
S37 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808000	3.91e-07
S45 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808000	3.91e-07
Signaling by CTNNB1 phospho-site mutants	15	5.89e-08	-0.808000	3.91e-07
Signaling by GSK3beta mutants	15	5.89e-08	-0.808000	3.91e-07
T41 mutants of beta-catenin aren’t phosphorylated	15	5.89e-08	-0.808000	3.91e-07
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.76e-07	-0.806000	1.07e-06
APC truncation mutants have impaired AXIN binding	14	2.29e-07	-0.798000	1.33e-06
AXIN missense mutants destabilize the destruction complex	14	2.29e-07	-0.798000	1.33e-06
Signaling by AMER1 mutants	14	2.29e-07	-0.798000	1.33e-06
Signaling by APC mutants	14	2.29e-07	-0.798000	1.33e-06
Signaling by AXIN mutants	14	2.29e-07	-0.798000	1.33e-06
Truncations of AMER1 destabilize the destruction complex	14	2.29e-07	-0.798000	1.33e-06
Signaling by Hippo	20	7.94e-10	-0.794000	7.32e-09
MET activates RAP1 and RAC1	11	5.41e-06	-0.792000	2.27e-05
MAPK3 (ERK1) activation	10	2.78e-05	-0.765000	1.00e-04
RAF-independent MAPK1/3 activation	23	2.16e-10	-0.764000	2.17e-09
Interleukin-6 signaling	11	1.18e-05	-0.763000	4.54e-05
Beta-catenin phosphorylation cascade	17	5.52e-08	-0.761000	3.83e-07
Mitotic Telophase/Cytokinesis	13	2.05e-06	-0.760000	9.40e-06
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	5.85e-11	-0.756000	6.52e-10
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	7.20e-06	-0.719000	2.92e-05
Defective EXT2 causes exostoses 2	13	7.20e-06	-0.719000	2.92e-05
Synthesis of PIPs at the early endosome membrane	16	1.38e-06	-0.697000	6.58e-06
Signaling by PDGFRA extracellular domain mutants	12	3.55e-05	-0.689000	1.24e-04
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.55e-05	-0.689000	1.24e-04
Activation of RAC1	13	1.72e-05	-0.688000	6.43e-05
Synthesis of PIPs at the late endosome membrane	11	8.35e-05	-0.685000	2.69e-04
Signal transduction by L1	21	5.62e-08	-0.684000	3.86e-07
ALK mutants bind TKIs	12	4.26e-05	-0.682000	1.46e-04
FOXO-mediated transcription of cell cycle genes	16	5.18e-06	-0.658000	2.18e-05
Syndecan interactions	20	5.15e-07	-0.648000	2.70e-06
Prolonged ERK activation events	14	2.87e-05	-0.646000	1.03e-04
CTLA4 inhibitory signaling	17	4.47e-06	-0.643000	1.92e-05
Gastrin-CREB signalling pathway via PKC and MAPK	17	4.75e-06	-0.641000	2.02e-05
Cell-extracellular matrix interactions	16	9.64e-06	-0.639000	3.82e-05
Regulation of gene expression by Hypoxia-inducible Factor	11	2.44e-04	-0.639000	7.14e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.95e-16	-0.634000	9.46e-15
Signaling by WNT in cancer	32	5.49e-10	-0.633000	5.19e-09
Processing and activation of SUMO	10	5.34e-04	-0.632000	1.43e-03
ERK/MAPK targets	22	2.85e-07	-0.632000	1.59e-06
Frs2-mediated activation	12	1.60e-04	-0.629000	4.86e-04
STAT5 activation downstream of FLT3 ITD mutants	10	5.78e-04	-0.628000	1.53e-03
Signaling by PDGFR in disease	20	1.17e-06	-0.628000	5.65e-06
Citric acid cycle (TCA cycle)	22	3.63e-07	-0.626000	1.96e-06
Signaling by Activin	15	2.67e-05	-0.626000	9.65e-05
Signaling by FGFR3 fusions in cancer	10	6.17e-04	-0.625000	1.62e-03
Postmitotic nuclear pore complex (NPC) reformation	27	2.73e-08	-0.618000	1.96e-07
tRNA processing in the mitochondrion	20	1.84e-06	0.616000	8.56e-06
Adenylate cyclase inhibitory pathway	12	2.21e-04	-0.616000	6.52e-04
RHO GTPases Activate WASPs and WAVEs	36	1.67e-10	-0.615000	1.73e-09
Uptake and function of anthrax toxins	11	4.20e-04	-0.614000	1.17e-03
Ephrin signaling	19	3.78e-06	-0.612000	1.65e-05
Spry regulation of FGF signaling	16	2.23e-05	-0.612000	8.18e-05
Deadenylation of mRNA	22	7.75e-07	-0.608000	3.92e-06
Platelet sensitization by LDL	16	2.53e-05	-0.608000	9.21e-05
GAB1 signalosome	17	1.42e-05	-0.608000	5.42e-05
Signaling by KIT in disease	19	4.46e-06	-0.608000	1.92e-05
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	4.46e-06	-0.608000	1.92e-05
ER Quality Control Compartment (ERQC)	21	1.53e-06	-0.606000	7.20e-06
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	1.91e-10	-0.605000	1.96e-09
HS-GAG biosynthesis	28	3.40e-08	-0.602000	2.42e-07
Endosomal/Vacuolar pathway	12	3.46e-04	-0.596000	9.82e-04
Calnexin/calreticulin cycle	26	1.40e-07	-0.596000	8.75e-07
Recycling pathway of L1	27	9.07e-08	-0.594000	5.87e-07
DCC mediated attractive signaling	14	1.26e-04	-0.592000	3.89e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	1.72e-09	-0.588000	1.43e-08
RHOF GTPase cycle	42	4.42e-11	-0.587000	5.16e-10
Activation of BAD and translocation to mitochondria	15	8.33e-05	-0.587000	2.69e-04
Signaling by FLT3 ITD and TKD mutants	16	4.90e-05	-0.586000	1.65e-04
CD209 (DC-SIGN) signaling	19	9.95e-06	-0.585000	3.92e-05
RORA activates gene expression	18	1.76e-05	-0.584000	6.56e-05
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	1.47e-03	-0.581000	3.50e-03
Cholesterol biosynthesis	24	9.00e-07	-0.579000	4.45e-06
Activation of gene expression by SREBF (SREBP)	42	9.33e-11	-0.577000	1.00e-09
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	11	9.79e-04	-0.574000	2.46e-03
COPI-independent Golgi-to-ER retrograde traffic	33	1.20e-08	-0.573000	8.82e-08
Nephrin family interactions	21	6.02e-06	-0.570000	2.51e-05
HDMs demethylate histones	23	2.21e-06	-0.570000	1.00e-05
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	1.13e-07	-0.569000	7.18e-07
PKA-mediated phosphorylation of CREB	18	3.50e-05	-0.563000	1.24e-04
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	5.58e-12	-0.563000	7.52e-11
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	17	6.36e-05	-0.560000	2.08e-04
Downstream signal transduction	29	1.83e-07	-0.559000	1.10e-06
Depolymerisation of the Nuclear Lamina	15	1.80e-04	-0.558000	5.46e-04
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	8.25e-04	-0.557000	2.11e-03
STAT3 nuclear events downstream of ALK signaling	10	2.27e-03	-0.557000	5.05e-03
Regulation of signaling by CBL	18	4.35e-05	-0.556000	1.49e-04
PKA activation	16	1.23e-04	-0.554000	3.83e-04
MECP2 regulates neuronal receptors and channels	17	7.66e-05	-0.554000	2.48e-04
EGR2 and SOX10-mediated initiation of Schwann cell myelination	25	1.95e-06	-0.550000	8.99e-06
GRB2:SOS provides linkage to MAPK signaling for Integrins	13	6.07e-04	-0.549000	1.60e-03
Signaling by TGF-beta Receptor Complex	74	3.43e-16	-0.548000	8.35e-15
IRAK2 mediated activation of TAK1 complex	10	2.72e-03	-0.547000	5.91e-03
RHO GTPases activate KTN1	11	1.66e-03	-0.547000	3.90e-03
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	24	3.43e-06	-0.547000	1.51e-05
TGF-beta receptor signaling activates SMADs	32	8.37e-08	-0.547000	5.47e-07
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	2.54e-07	-0.544000	1.44e-06
Miscellaneous transport and binding events	23	6.84e-06	-0.542000	2.81e-05
Interleukin-27 signaling	10	3.02e-03	-0.542000	6.49e-03
FCGR3A-mediated phagocytosis	57	1.50e-12	-0.541000	2.12e-11
Leishmania phagocytosis	57	1.50e-12	-0.541000	2.12e-11
Parasite infection	57	1.50e-12	-0.541000	2.12e-11
Defective B4GALT7 causes EDS, progeroid type	19	4.50e-05	-0.541000	1.54e-04
Synthesis of PIPs at the Golgi membrane	16	1.81e-04	-0.540000	5.48e-04
Negative regulation of MET activity	21	1.85e-05	-0.540000	6.89e-05
Attenuation phase	23	7.45e-06	-0.540000	2.99e-05
Role of LAT2/NTAL/LAB on calcium mobilization	13	7.63e-04	-0.539000	1.96e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	7.58e-05	-0.539000	2.46e-04
Signal regulatory protein family interactions	11	1.99e-03	-0.538000	4.47e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.97e-04	-0.537000	5.89e-04
VEGFR2 mediated cell proliferation	19	4.98e-05	-0.537000	1.67e-04
COPI-mediated anterograde transport	79	1.41e-16	-0.537000	3.68e-15
Insulin processing	25	3.98e-06	-0.533000	1.72e-05
EPHA-mediated growth cone collapse	15	3.55e-04	-0.533000	1.00e-03
Cargo concentration in the ER	31	2.90e-07	-0.532000	1.61e-06
IRE1alpha activates chaperones	50	7.93e-11	-0.531000	8.78e-10
Golgi Associated Vesicle Biogenesis	55	9.55e-12	-0.531000	1.28e-10
Interleukin-15 signaling	14	6.01e-04	-0.530000	1.59e-03
SUMOylation of SUMOylation proteins	35	5.87e-08	-0.529000	3.91e-07
Downregulation of TGF-beta receptor signaling	26	2.96e-06	-0.529000	1.31e-05
Signaling by ALK fusions and activated point mutants	55	1.15e-11	-0.529000	1.49e-10
Signaling by ALK in cancer	55	1.15e-11	-0.529000	1.49e-10
Non-integrin membrane-ECM interactions	42	3.14e-09	-0.528000	2.53e-08
Transport of Ribonucleoproteins into the Host Nucleus	32	2.53e-07	-0.526000	1.44e-06
MET promotes cell motility	29	9.43e-07	-0.526000	4.64e-06
p130Cas linkage to MAPK signaling for integrins	13	1.03e-03	-0.526000	2.56e-03
RHOV GTPase cycle	37	3.12e-08	-0.526000	2.23e-07
MAPK targets/ Nuclear events mediated by MAP kinases	31	4.13e-07	-0.525000	2.19e-06
Golgi-to-ER retrograde transport	113	5.19e-22	-0.524000	2.20e-20
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.10e-03	-0.523000	2.70e-03
CaMK IV-mediated phosphorylation of CREB	10	4.30e-03	-0.521000	8.81e-03
Zinc transporters	14	7.31e-04	-0.521000	1.89e-03
Downregulation of SMAD2/3:SMAD4 transcriptional activity	28	1.84e-06	-0.521000	8.56e-06
The role of Nef in HIV-1 replication and disease pathogenesis	23	1.54e-05	-0.520000	5.83e-05
Export of Viral Ribonucleoproteins from Nucleus	33	2.31e-07	-0.520000	1.33e-06
Circadian Clock	67	1.89e-13	-0.519000	3.29e-12
MAP kinase activation	63	9.78e-13	-0.519000	1.45e-11
NEP/NS2 Interacts with the Cellular Export Machinery	32	3.68e-07	-0.519000	1.98e-06
Nuclear import of Rev protein	34	1.66e-07	-0.518000	1.01e-06
VEGFR2 mediated vascular permeability	26	4.70e-06	-0.518000	2.00e-05
VLDLR internalisation and degradation	11	2.91e-03	-0.518000	6.27e-03
RAF activation	34	1.78e-07	-0.517000	1.07e-06
Signaling by TGFB family members	98	9.14e-19	-0.516000	3.01e-17
Receptor Mediated Mitophagy	11	3.03e-03	-0.516000	6.49e-03
Transport of the SLBP Dependant Mature mRNA	36	8.58e-08	-0.515000	5.58e-07
RAC2 GTPase cycle	86	1.56e-16	-0.514000	3.92e-15
XBP1(S) activates chaperone genes	48	6.95e-10	-0.514000	6.53e-09
N-Glycan antennae elongation	14	8.75e-04	-0.514000	2.23e-03
Glutamate and glutamine metabolism	13	1.36e-03	-0.513000	3.29e-03
Caspase activation via Dependence Receptors in the absence of ligand	10	5.12e-03	-0.511000	1.03e-02
Interactions of Vpr with host cellular proteins	37	7.83e-08	-0.510000	5.14e-07
Signaling by FLT3 fusion proteins	19	1.20e-04	-0.509000	3.76e-04
Signaling by EGFR	50	4.80e-10	-0.509000	4.60e-09
Interactions of Rev with host cellular proteins	37	9.21e-08	-0.507000	5.94e-07
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	3.95e-09	-0.507000	3.11e-08
Transport of the SLBP independent Mature mRNA	35	2.10e-07	-0.507000	1.25e-06
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	1.61e-03	-0.505000	3.79e-03
Folding of actin by CCT/TriC	10	5.70e-03	-0.505000	1.13e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	181	8.03e-32	-0.505000	6.27e-30
COPI-dependent Golgi-to-ER retrograde traffic	80	6.87e-15	-0.503000	1.50e-13
RHOH GTPase cycle	35	2.56e-07	-0.503000	1.44e-06
Negative regulation of MAPK pathway	43	1.15e-08	-0.503000	8.58e-08
RHOU GTPase cycle	40	3.75e-08	-0.503000	2.65e-07
TICAM1,TRAF6-dependent induction of TAK1 complex	11	3.90e-03	-0.503000	8.07e-03
Josephin domain DUBs	10	6.02e-03	-0.502000	1.18e-02
Signaling by Leptin	10	6.05e-03	-0.501000	1.19e-02
Complex I biogenesis	57	5.81e-11	0.501000	6.52e-10
Rev-mediated nuclear export of HIV RNA	35	2.90e-07	-0.501000	1.61e-06
MET activates PTK2 signaling	18	2.36e-04	-0.500000	6.94e-04
VEGFA-VEGFR2 Pathway	91	1.51e-16	-0.500000	3.85e-15
BMAL1:CLOCK,NPAS2 activates circadian gene expression	26	1.01e-05	-0.500000	3.98e-05
Pentose phosphate pathway	13	1.83e-03	-0.499000	4.19e-03
Protein ubiquitination	73	1.74e-13	-0.498000	3.08e-12
Signaling by VEGF	100	6.79e-18	-0.498000	2.01e-16
Growth hormone receptor signaling	20	1.16e-04	-0.498000	3.65e-04
Nucleotide biosynthesis	12	2.86e-03	-0.497000	6.18e-03
Nuclear Pore Complex (NPC) Disassembly	36	2.55e-07	-0.496000	1.44e-06
Extra-nuclear estrogen signaling	70	6.86e-13	-0.496000	1.05e-11
Listeria monocytogenes entry into host cells	20	1.24e-04	-0.496000	3.85e-04
RHO GTPases activate IQGAPs	11	4.43e-03	-0.495000	9.07e-03
RHOD GTPase cycle	53	4.65e-10	-0.494000	4.48e-09
Regulation of actin dynamics for phagocytic cup formation	59	5.68e-11	-0.493000	6.43e-10
Regulation of localization of FOXO transcription factors	12	3.18e-03	-0.492000	6.78e-03
Ovarian tumor domain proteases	38	1.56e-07	-0.492000	9.64e-07
Glycogen synthesis	15	9.85e-04	-0.491000	2.47e-03
Vpr-mediated nuclear import of PICs	34	7.45e-07	-0.490000	3.80e-06
HSF1 activation	26	1.50e-05	-0.490000	5.69e-05
Regulation of IFNG signaling	13	2.21e-03	-0.490000	4.92e-03
Aflatoxin activation and detoxification	14	1.55e-03	0.489000	3.68e-03
RHOG GTPase cycle	74	3.55e-13	-0.489000	5.85e-12
ISG15 antiviral mechanism	73	5.63e-13	-0.488000	8.70e-12
Tie2 Signaling	17	5.02e-04	-0.487000	1.36e-03
Oncogenic MAPK signaling	78	1.01e-13	-0.487000	1.92e-12
Interleukin-35 Signalling	12	3.52e-03	-0.486000	7.38e-03
SUMOylation of ubiquitinylation proteins	39	1.62e-07	-0.485000	9.90e-07
MET receptor recycling	10	8.07e-03	-0.484000	1.53e-02
Regulation of RUNX1 Expression and Activity	18	3.80e-04	-0.484000	1.06e-03
Transport to the Golgi and subsequent modification	160	3.97e-26	-0.484000	2.26e-24
Association of TriC/CCT with target proteins during biosynthesis	37	3.55e-07	-0.484000	1.93e-06
Signaling by FGFR4 in disease	11	5.59e-03	-0.482000	1.11e-02
Regulation of commissural axon pathfinding by SLIT and ROBO	10	8.34e-03	-0.482000	1.57e-02
InlB-mediated entry of Listeria monocytogenes into host cell	15	1.25e-03	-0.481000	3.04e-03
Defective B3GAT3 causes JDSSDHD	19	2.82e-04	-0.481000	8.18e-04
ER to Golgi Anterograde Transport	131	2.45e-21	-0.479000	9.58e-20
E3 ubiquitin ligases ubiquitinate target proteins	53	1.63e-09	-0.479000	1.37e-08
Nuclear Envelope Breakdown	53	1.68e-09	-0.478000	1.41e-08
RHOJ GTPase cycle	54	1.19e-09	-0.478000	1.01e-08
Antiviral mechanism by IFN-stimulated genes	81	1.08e-13	-0.477000	2.02e-12
Keratan sulfate biosynthesis	24	5.25e-05	-0.477000	1.75e-04
EPHB-mediated forward signaling	34	1.73e-06	-0.474000	8.10e-06
Regulation of HSF1-mediated heat shock response	78	4.74e-13	-0.473000	7.64e-12
activated TAK1 mediates p38 MAPK activation	19	3.56e-04	-0.473000	1.01e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	3.79e-06	-0.472000	1.65e-05
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	3.79e-06	-0.472000	1.65e-05
MyD88 cascade initiated on plasma membrane	81	2.15e-13	-0.471000	3.62e-12
Toll Like Receptor 10 (TLR10) Cascade	81	2.15e-13	-0.471000	3.62e-12
Toll Like Receptor 5 (TLR5) Cascade	81	2.15e-13	-0.471000	3.62e-12
Erythropoietin activates RAS	14	2.27e-03	-0.471000	5.04e-03
Ca-dependent events	34	2.02e-06	-0.471000	9.27e-06
Regulation of KIT signaling	15	1.60e-03	-0.471000	3.77e-03
IRAK1 recruits IKK complex	10	9.99e-03	-0.470000	1.85e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	9.99e-03	-0.470000	1.85e-02
Heme signaling	42	1.39e-07	-0.469000	8.71e-07
Defective B3GALT6 causes EDSP2 and SEMDJL1	19	4.05e-04	-0.469000	1.13e-03
rRNA processing in the mitochondrion	24	7.05e-05	0.469000	2.29e-04
Fcgamma receptor (FCGR) dependent phagocytosis	84	1.23e-13	-0.468000	2.26e-12
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	31	6.64e-06	-0.467000	2.74e-05
NS1 Mediated Effects on Host Pathways	41	2.24e-07	-0.467000	1.33e-06
RUNX3 regulates NOTCH signaling	14	2.52e-03	-0.466000	5.52e-03
G-protein mediated events	50	1.17e-08	-0.466000	8.68e-08
Asparagine N-linked glycosylation	276	1.13e-40	-0.466000	1.40e-38
EGFR downregulation	31	7.35e-06	-0.465000	2.95e-05
SUMOylation of DNA replication proteins	46	4.89e-08	-0.465000	3.43e-07
p75NTR signals via NF-kB	16	1.31e-03	-0.464000	3.16e-03
GPVI-mediated activation cascade	30	1.08e-05	-0.464000	4.21e-05
CD28 co-stimulation	29	1.56e-05	-0.463000	5.86e-05
Glycolysis	67	5.29e-11	-0.463000	6.04e-10
RHOQ GTPase cycle	58	1.06e-09	-0.463000	9.50e-09
mRNA decay by 5’ to 3’ exoribonuclease	15	1.92e-03	-0.463000	4.35e-03
Toll Like Receptor 3 (TLR3) Cascade	90	3.35e-14	-0.462000	6.72e-13
SHC1 events in EGFR signaling	14	2.77e-03	-0.462000	6.01e-03
Cellular response to heat stress	96	5.10e-15	-0.462000	1.13e-13
Signaling by SCF-KIT	41	3.60e-07	-0.459000	1.95e-06
Diseases associated with glycosaminoglycan metabolism	36	1.89e-06	-0.459000	8.74e-06
Sodium/Calcium exchangers	11	8.54e-03	-0.458000	1.60e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	7.72e-04	-0.458000	1.98e-03
Keratan sulfate/keratin metabolism	29	1.99e-05	-0.458000	7.35e-05
Formation of tubulin folding intermediates by CCT/TriC	23	1.48e-04	-0.457000	4.54e-04
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	3.10e-03	-0.456000	6.64e-03
Nuclear Events (kinase and transcription factor activation)	60	9.86e-10	-0.456000	8.91e-09
Signaling by Erythropoietin	25	7.92e-05	-0.456000	2.56e-04
RAC3 GTPase cycle	91	5.65e-14	-0.455000	1.10e-12
DAG and IP3 signaling	38	1.17e-06	-0.455000	5.67e-06
Interleukin-17 signaling	68	8.11e-11	-0.455000	8.90e-10
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	4.25e-04	-0.455000	1.17e-03
Neurodegenerative Diseases	20	4.25e-04	-0.455000	1.17e-03
FCERI mediated Ca+2 mobilization	28	3.08e-05	-0.455000	1.10e-04
Gap junction degradation	10	1.28e-02	-0.455000	2.28e-02
Signaling by NTRK1 (TRKA)	113	6.72e-17	-0.454000	1.78e-15
RHO GTPases activate CIT	19	6.36e-04	-0.453000	1.67e-03
GRB2 events in EGFR signaling	13	4.86e-03	-0.451000	9.86e-03
Transcriptional activation of mitochondrial biogenesis	53	1.43e-08	-0.450000	1.04e-07
Constitutive Signaling by Overexpressed ERBB2	11	9.81e-03	-0.450000	1.83e-02
Metal ion SLC transporters	23	1.89e-04	-0.450000	5.68e-04
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	1.85e-03	-0.450000	4.23e-03
Mitophagy	28	3.87e-05	-0.449000	1.35e-04
DARPP-32 events	23	1.92e-04	-0.449000	5.78e-04
Membrane Trafficking	583	1.95e-77	-0.449000	7.21e-75
YAP1- and WWTR1 (TAZ)-stimulated gene expression	13	5.23e-03	-0.447000	1.05e-02
N-glycan antennae elongation in the medial/trans-Golgi	24	1.49e-04	-0.447000	4.54e-04
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	27	5.87e-05	-0.447000	1.94e-04
Signaling by cytosolic FGFR1 fusion mutants	18	1.05e-03	-0.446000	2.62e-03
Signaling by NODAL	20	5.61e-04	-0.446000	1.50e-03
Signal amplification	29	3.27e-05	-0.445000	1.17e-04
FLT3 Signaling	37	2.77e-06	-0.445000	1.23e-05
Cyclin A/B1/B2 associated events during G2/M transition	25	1.18e-04	-0.445000	3.71e-04
PLC beta mediated events	46	1.91e-07	-0.444000	1.14e-06
Signaling by MET	66	4.61e-10	-0.443000	4.46e-09
PINK1-PRKN Mediated Mitophagy	21	4.44e-04	-0.443000	1.21e-03
ATF6 (ATF6-alpha) activates chaperones	12	7.95e-03	-0.442000	1.51e-02
CaM pathway	32	1.50e-05	-0.442000	5.69e-05
Calmodulin induced events	32	1.50e-05	-0.442000	5.69e-05
Selective autophagy	58	5.75e-09	-0.442000	4.46e-08
Pexophagy	11	1.14e-02	-0.440000	2.07e-02
FLT3 signaling in disease	28	5.49e-05	-0.440000	1.82e-04
RND1 GTPase cycle	42	7.86e-07	-0.440000	3.95e-06
SARS-CoV-2 Infection	71	1.49e-10	-0.439000	1.56e-09
Regulated proteolysis of p75NTR	11	1.16e-02	-0.439000	2.10e-02
PECAM1 interactions	11	1.19e-02	-0.438000	2.14e-02
Nuclear events stimulated by ALK signaling in cancer	19	9.49e-04	-0.438000	2.40e-03
Signaling by BRAF and RAF1 fusions	61	3.35e-09	-0.437000	2.69e-08
Cargo recognition for clathrin-mediated endocytosis	101	3.06e-14	-0.437000	6.22e-13
Intra-Golgi traffic	43	7.34e-07	-0.436000	3.75e-06
Clathrin-mediated endocytosis	139	6.16e-19	-0.436000	2.09e-17
Toll Like Receptor 9 (TLR9) Cascade	91	6.97e-13	-0.435000	1.06e-11
HSF1-dependent transactivation	33	1.56e-05	-0.434000	5.86e-05
HuR (ELAVL1) binds and stabilizes mRNA	10	1.75e-02	-0.434000	3.00e-02
COPII-mediated vesicle transport	66	1.07e-09	-0.434000	9.52e-09
Apoptotic cleavage of cell adhesion proteins	10	1.77e-02	-0.433000	3.04e-02
Interleukin-6 family signaling	23	3.29e-04	-0.433000	9.39e-04
Signaling by CSF3 (G-CSF)	30	4.22e-05	-0.432000	1.45e-04
EPH-Ephrin signaling	91	1.05e-12	-0.432000	1.54e-11
Integrin signaling	25	1.88e-04	-0.431000	5.65e-04
MyD88-independent TLR4 cascade	94	5.43e-13	-0.430000	8.48e-12
TRIF(TICAM1)-mediated TLR4 signaling	94	5.43e-13	-0.430000	8.48e-12
Constitutive Signaling by EGFRvIII	15	4.01e-03	-0.429000	8.27e-03
Signaling by EGFRvIII in Cancer	15	4.01e-03	-0.429000	8.27e-03
MHC class II antigen presentation	98	2.23e-13	-0.428000	3.72e-12
Signaling by NTRKs	131	2.42e-17	-0.428000	7.03e-16
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.18e-06	-0.428000	5.69e-06
Vesicle-mediated transport	614	5.47e-74	-0.428000	1.35e-71
Dissolution of Fibrin Clot	12	1.03e-02	-0.427000	1.89e-02
RET signaling	37	6.89e-06	-0.427000	2.81e-05
Regulation of FOXO transcriptional activity by acetylation	10	1.99e-02	-0.425000	3.37e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	93	1.37e-12	-0.425000	1.99e-11
Apoptotic cleavage of cellular proteins	36	1.03e-05	-0.425000	4.04e-05
Retrograde neurotrophin signalling	14	5.94e-03	-0.425000	1.17e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.49e-02	-0.424000	2.63e-02
PKA activation in glucagon signalling	15	4.50e-03	-0.424000	9.19e-03
Regulation of TP53 Expression and Degradation	36	1.11e-05	-0.423000	4.29e-05
Translesion Synthesis by POLH	18	1.88e-03	-0.423000	4.29e-03
Signalling to ERKs	33	2.60e-05	-0.423000	9.44e-05
Sphingolipid de novo biosynthesis	42	2.17e-06	-0.422000	9.86e-06
Signaling by BMP	23	4.64e-04	-0.422000	1.26e-03
RND3 GTPase cycle	41	3.40e-06	-0.419000	1.50e-05
SHC1 events in ERBB2 signaling	22	6.68e-04	-0.419000	1.74e-03
Interleukin-7 signaling	23	5.05e-04	-0.419000	1.36e-03
PI3K events in ERBB2 signaling	16	3.72e-03	-0.419000	7.77e-03
Transport of Mature mRNA Derived from an Intronless Transcript	42	2.64e-06	-0.419000	1.18e-05
Signaling by ERBB2 ECD mutants	16	3.75e-03	-0.418000	7.83e-03
Regulation of TP53 Degradation	35	1.94e-05	-0.417000	7.18e-05
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	86	2.34e-11	-0.417000	2.84e-10
MyD88 dependent cascade initiated on endosome	87	1.82e-11	-0.416000	2.27e-10
Toll Like Receptor 7/8 (TLR7/8) Cascade	87	1.82e-11	-0.416000	2.27e-10
Nuclear Envelope (NE) Reassembly	73	7.64e-10	-0.416000	7.09e-09
PPARA activates gene expression	112	3.04e-14	-0.415000	6.22e-13
Alpha-protein kinase 1 signaling pathway	11	1.71e-02	-0.415000	2.95e-02
EPH-ephrin mediated repulsion of cells	48	6.50e-07	-0.415000	3.36e-06
Condensation of Prometaphase Chromosomes	11	1.73e-02	-0.415000	2.97e-02
Initiation of Nuclear Envelope (NE) Reformation	19	1.80e-03	-0.414000	4.13e-03
Translation of Replicase and Assembly of the Replication Transcription Complex	13	9.87e-03	-0.413000	1.83e-02
Negative regulation of the PI3K/AKT network	100	9.14e-13	-0.413000	1.37e-11
MASTL Facilitates Mitotic Progression	10	2.40e-02	-0.412000	3.95e-02
Kinesins	41	4.91e-06	-0.412000	2.07e-05
trans-Golgi Network Vesicle Budding	71	1.88e-09	-0.412000	1.55e-08
Autophagy	125	1.68e-15	-0.412000	3.77e-14
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	11	1.83e-02	-0.411000	3.13e-02
Netrin-1 signaling	46	1.63e-06	-0.408000	7.69e-06
Macroautophagy	112	8.16e-14	-0.408000	1.57e-12
Retrograde transport at the Trans-Golgi-Network	49	7.68e-07	-0.408000	3.90e-06
RHOC GTPase cycle	72	2.12e-09	-0.408000	1.73e-08
Synthesis of PIPs at the plasma membrane	50	6.17e-07	-0.407000	3.20e-06
Diseases associated with glycosylation precursor biosynthesis	18	2.78e-03	-0.407000	6.01e-03
Regulation of lipid metabolism by PPARalpha	114	5.58e-14	-0.407000	1.10e-12
Constitutive Signaling by AKT1 E17K in Cancer	26	3.39e-04	-0.406000	9.65e-04
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	2.50e-05	-0.406000	9.13e-05
Opioid Signalling	82	2.17e-10	-0.405000	2.17e-09
Gap junction trafficking and regulation	20	1.71e-03	-0.405000	3.98e-03
DAP12 interactions	33	5.80e-05	-0.404000	1.92e-04
Signaling by ALK	26	3.64e-04	-0.404000	1.03e-03
TBC/RABGAPs	43	4.79e-06	-0.403000	2.03e-05
Signaling by NTRK3 (TRKC)	16	5.39e-03	-0.402000	1.08e-02
Diseases of signal transduction by growth factor receptors and second messengers	412	1.26e-44	-0.401000	1.87e-42
Defective Intrinsic Pathway for Apoptosis	22	1.14e-03	-0.401000	2.81e-03
Cell-Cell communication	110	4.19e-13	-0.400000	6.83e-12
Pre-NOTCH Processing in Golgi	18	3.41e-03	-0.399000	7.19e-03
ERBB2 Regulates Cell Motility	15	7.52e-03	-0.399000	1.44e-02
A tetrasaccharide linker sequence is required for GAG synthesis	25	5.75e-04	-0.398000	1.53e-03
Laminin interactions	23	9.81e-04	-0.397000	2.46e-03
Response of Mtb to phagocytosis	22	1.29e-03	-0.396000	3.13e-03
SARS-CoV Infections	152	3.24e-17	-0.396000	9.23e-16
Membrane binding and targetting of GAG proteins	14	1.03e-02	-0.396000	1.89e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.03e-02	-0.396000	1.89e-02
Signaling by RAF1 mutants	37	3.15e-05	-0.395000	1.13e-04
L1CAM interactions	94	4.20e-11	-0.393000	4.95e-10
ESR-mediated signaling	177	1.60e-19	-0.393000	5.79e-18
Signaling by ERBB2	50	1.51e-06	-0.393000	7.15e-06
RHOBTB GTPase Cycle	35	5.99e-05	-0.392000	1.97e-04
VxPx cargo-targeting to cilium	19	3.12e-03	-0.392000	6.67e-03
WNT5A-dependent internalization of FZD4	15	8.64e-03	-0.392000	1.62e-02
RAB geranylgeranylation	62	9.59e-08	-0.391000	6.16e-07
Peptide chain elongation	87	2.83e-10	0.391000	2.79e-09
Resolution of Sister Chromatid Cohesion	105	4.36e-12	-0.391000	5.97e-11
LDL clearance	17	5.28e-03	-0.391000	1.06e-02
Sialic acid metabolism	30	2.13e-04	-0.391000	6.29e-04
Fatty acyl-CoA biosynthesis	35	6.71e-05	-0.389000	2.19e-04
PI Metabolism	78	2.74e-09	-0.389000	2.23e-08
NOTCH3 Intracellular Domain Regulates Transcription	23	1.25e-03	-0.389000	3.04e-03
NF-kB is activated and signals survival	13	1.53e-02	-0.389000	2.68e-02
Acetylcholine regulates insulin secretion	10	3.35e-02	-0.388000	5.33e-02
Reduction of cytosolic Ca++ levels	12	2.00e-02	-0.388000	3.39e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	3.52e-03	-0.387000	7.38e-03
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	3.52e-03	-0.387000	7.38e-03
Viral mRNA Translation	87	4.49e-10	0.387000	4.38e-09
Signaling by Non-Receptor Tyrosine Kinases	54	8.98e-07	-0.386000	4.45e-06
Signaling by PTK6	54	8.98e-07	-0.386000	4.45e-06
Regulation of PTEN mRNA translation	12	2.05e-02	-0.386000	3.46e-02
Signaling by EGFR in Cancer	25	8.38e-04	-0.386000	2.13e-03
Transcriptional regulation of white adipocyte differentiation	82	1.53e-09	-0.386000	1.30e-08
ATF6 (ATF6-alpha) activates chaperone genes	10	3.50e-02	-0.385000	5.51e-02
SUMOylation of RNA binding proteins	47	5.41e-06	-0.383000	2.27e-05
Post NMDA receptor activation events	58	4.44e-07	-0.383000	2.33e-06
Selenocysteine synthesis	91	2.68e-10	0.383000	2.66e-09
Costimulation by the CD28 family	59	3.91e-07	-0.382000	2.09e-06
RHOBTB1 GTPase cycle	23	1.62e-03	-0.380000	3.80e-03
RHO GTPases activate PAKs	21	2.63e-03	-0.379000	5.74e-03
RHO GTPases Activate ROCKs	19	4.28e-03	-0.379000	8.79e-03
Glycosaminoglycan metabolism	112	4.39e-12	-0.378000	5.97e-11
Negative regulation of FLT3	15	1.12e-02	-0.378000	2.04e-02
CD28 dependent PI3K/Akt signaling	18	5.58e-03	-0.377000	1.11e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	26	8.78e-04	-0.377000	2.23e-03
RAB GEFs exchange GTP for GDP on RABs	88	1.04e-09	-0.376000	9.33e-09
Infection with Mycobacterium tuberculosis	24	1.42e-03	-0.376000	3.42e-03
TP53 Regulates Transcription of Cell Cycle Genes	48	6.64e-06	-0.376000	2.74e-05
Physiological factors	11	3.12e-02	-0.375000	4.98e-02
Diseases associated with N-glycosylation of proteins	17	7.50e-03	-0.375000	1.44e-02
Formation of RNA Pol II elongation complex	57	9.98e-07	-0.374000	4.88e-06
RNA Polymerase II Transcription Elongation	57	9.98e-07	-0.374000	4.88e-06
ADP signalling through P2Y purinoceptor 1	23	1.91e-03	-0.374000	4.34e-03
RND2 GTPase cycle	41	3.46e-05	-0.374000	1.23e-04
Phase 2 - plateau phase	15	1.22e-02	0.374000	2.19e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling	39	5.47e-05	-0.373000	1.82e-04
HS-GAG degradation	20	3.87e-03	-0.373000	8.03e-03
AKT phosphorylates targets in the cytosol	14	1.57e-02	-0.373000	2.72e-02
Eukaryotic Translation Termination	91	7.58e-10	0.373000	7.07e-09
Mitotic Prophase	104	4.85e-11	-0.373000	5.62e-10
Regulation of IFNA signaling	13	2.00e-02	-0.373000	3.39e-02
p75NTR recruits signalling complexes	13	2.01e-02	-0.372000	3.40e-02
Telomere C-strand synthesis initiation	13	2.02e-02	-0.372000	3.41e-02
FCGR3A-mediated IL10 synthesis	34	1.74e-04	-0.372000	5.29e-04
Pyruvate metabolism and Citric Acid (TCA) cycle	53	2.86e-06	-0.371000	1.27e-05
GRB2 events in ERBB2 signaling	16	1.02e-02	-0.371000	1.87e-02
Sema3A PAK dependent Axon repulsion	16	1.04e-02	-0.370000	1.90e-02
Viral Messenger RNA Synthesis	44	2.23e-05	-0.369000	8.17e-05
mTORC1-mediated signalling	24	1.77e-03	-0.369000	4.10e-03
Suppression of phagosomal maturation	13	2.17e-02	-0.368000	3.63e-02
Late Phase of HIV Life Cycle	135	1.75e-13	-0.367000	3.08e-12
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	4.90e-05	-0.366000	1.65e-04
Signaling by RAS mutants	41	4.90e-05	-0.366000	1.65e-04
Signaling by moderate kinase activity BRAF mutants	41	4.90e-05	-0.366000	1.65e-04
Signaling downstream of RAS mutants	41	4.90e-05	-0.366000	1.65e-04
WNT ligand biogenesis and trafficking	23	2.39e-03	-0.366000	5.29e-03
Activation of NMDA receptors and postsynaptic events	71	1.00e-07	-0.365000	6.37e-07
PI3K/AKT Signaling in Cancer	93	1.11e-09	-0.365000	9.78e-09
MET activates RAS signaling	11	3.60e-02	-0.365000	5.65e-02
Intracellular signaling by second messengers	292	5.67e-27	-0.365000	3.66e-25
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	4.61e-02	-0.364000	7.02e-02
Heparan sulfate/heparin (HS-GAG) metabolism	51	6.87e-06	-0.364000	2.81e-05
Formation of ATP by chemiosmotic coupling	18	7.57e-03	0.364000	1.45e-02
Gap junction trafficking	18	7.60e-03	-0.363000	1.45e-02
PI3K events in ERBB4 signaling	10	4.77e-02	-0.362000	7.16e-02
Host Interactions of HIV factors	124	3.40e-12	-0.362000	4.71e-11
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	5.25e-03	-0.360000	1.05e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	3.07e-02	-0.360000	4.92e-02
alpha-linolenic acid (ALA) metabolism	12	3.07e-02	-0.360000	4.92e-02
Adherens junctions interactions	29	7.91e-04	-0.360000	2.03e-03
Glucose metabolism	84	1.16e-08	-0.360000	8.65e-08
DAP12 signaling	26	1.52e-03	-0.359000	3.61e-03
RHOB GTPase cycle	69	2.47e-07	-0.359000	1.41e-06
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	96	1.19e-09	-0.359000	1.01e-08
Toll Like Receptor 2 (TLR2) Cascade	96	1.19e-09	-0.359000	1.01e-08
Toll Like Receptor TLR1:TLR2 Cascade	96	1.19e-09	-0.359000	1.01e-08
Toll Like Receptor TLR6:TLR2 Cascade	96	1.19e-09	-0.359000	1.01e-08
Inactivation of CSF3 (G-CSF) signaling	25	1.90e-03	-0.359000	4.33e-03
Prolactin receptor signaling	11	3.99e-02	-0.358000	6.21e-02
Thrombin signalling through proteinase activated receptors (PARs)	30	6.97e-04	-0.358000	1.81e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	4.02e-02	-0.357000	6.25e-02
Potential therapeutics for SARS	83	1.92e-08	-0.357000	1.40e-07
Signaling by high-kinase activity BRAF mutants	32	4.82e-04	-0.356000	1.31e-03
Free fatty acids regulate insulin secretion	10	5.10e-02	-0.356000	7.61e-02
NOTCH1 Intracellular Domain Regulates Transcription	48	1.97e-05	-0.356000	7.27e-05
Signaling by ERBB2 in Cancer	26	1.69e-03	-0.356000	3.94e-03
HIV Infection	222	6.60e-20	-0.355000	2.51e-18
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	92	3.85e-09	-0.355000	3.06e-08
Amplification of signal from the kinetochores	92	3.85e-09	-0.355000	3.06e-08
HIV Life Cycle	147	1.09e-13	-0.355000	2.03e-12
FCERI mediated MAPK activation	29	9.56e-04	-0.354000	2.41e-03
EML4 and NUDC in mitotic spindle formation	96	1.95e-09	-0.354000	1.61e-08
Removal of the Flap Intermediate from the C-strand	17	1.15e-02	-0.354000	2.09e-02
Rab regulation of trafficking	120	2.17e-11	-0.353000	2.66e-10
NGF-stimulated transcription	38	1.66e-04	-0.353000	5.04e-04
Cyclin D associated events in G1	45	4.21e-05	-0.353000	1.45e-04
G1 Phase	45	4.21e-05	-0.353000	1.45e-04
Transcriptional regulation by RUNX3	93	4.02e-09	-0.353000	3.16e-08
Initial triggering of complement	14	2.24e-02	0.352000	3.74e-02
PIP3 activates AKT signaling	255	3.13e-22	-0.352000	1.45e-20
SHC1 events in ERBB4 signaling	14	2.29e-02	-0.351000	3.81e-02
RHO GTPases Activate Formins	119	3.57e-11	-0.351000	4.27e-10
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	9.95e-03	-0.351000	1.84e-02
SUMOylation of DNA damage response and repair proteins	76	1.22e-07	-0.351000	7.67e-07
Eukaryotic Translation Elongation	92	5.98e-09	0.351000	4.60e-08
Assembly Of The HIV Virion	16	1.52e-02	-0.351000	2.67e-02
RHO GTPase Effectors	258	3.57e-22	-0.349000	1.58e-20
G alpha (z) signalling events	42	8.99e-05	-0.349000	2.88e-04
Toll Like Receptor 4 (TLR4) Cascade	124	2.15e-11	-0.348000	2.65e-10
Fc epsilon receptor (FCERI) signaling	128	1.03e-11	-0.348000	1.35e-10
Glucagon signaling in metabolic regulation	29	1.31e-03	-0.345000	3.16e-03
RNA Polymerase II Pre-transcription Events	80	9.71e-08	-0.345000	6.21e-07
Regulation of MECP2 expression and activity	30	1.08e-03	-0.345000	2.68e-03
Antigen processing: Ubiquitination & Proteasome degradation	293	2.96e-24	-0.344000	1.57e-22
Unfolded Protein Response (UPR)	92	1.19e-08	-0.344000	8.81e-08
Constitutive Signaling by Aberrant PI3K in Cancer	66	1.39e-06	-0.343000	6.63e-06
ADP signalling through P2Y purinoceptor 12	18	1.19e-02	-0.342000	2.15e-02
Synthesis of substrates in N-glycan biosythesis	60	4.53e-06	-0.342000	1.94e-05
Translation of Structural Proteins	29	1.43e-03	-0.342000	3.43e-03
Cell junction organization	79	1.53e-07	-0.341000	9.50e-07
Platelet calcium homeostasis	25	3.21e-03	-0.340000	6.82e-03
Formation of Incision Complex in GG-NER	43	1.17e-04	-0.339000	3.69e-04
Class I MHC mediated antigen processing & presentation	357	2.86e-28	-0.339000	1.93e-26
TNFR1-induced proapoptotic signaling	13	3.46e-02	-0.338000	5.48e-02
Apoptotic execution phase	49	4.22e-05	-0.338000	1.45e-04
Signaling by WNT	281	1.54e-22	-0.338000	7.63e-21
Signaling by ERBB2 KD Mutants	25	3.46e-03	-0.338000	7.29e-03
Thromboxane signalling through TP receptor	22	6.13e-03	-0.338000	1.20e-02
Signaling by NOTCH1	74	5.17e-07	-0.337000	2.70e-06
Signaling by FGFR3	38	3.22e-04	-0.337000	9.23e-04
Interleukin-1 signaling	97	9.47e-09	-0.337000	7.17e-08
Cytochrome c-mediated apoptotic response	13	3.54e-02	-0.337000	5.57e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	646	1.21e-48	-0.336000	2.23e-46
Energy dependent regulation of mTOR by LKB1-AMPK	28	2.06e-03	-0.336000	4.62e-03
CLEC7A (Dectin-1) signaling	97	1.05e-08	-0.336000	7.92e-08
Negative regulation of FGFR3 signaling	27	2.54e-03	-0.336000	5.55e-03
RAS processing	19	1.14e-02	-0.335000	2.06e-02
SUMOylation of chromatin organization proteins	57	1.18e-05	-0.335000	4.54e-05
Signaling by Rho GTPases	630	3.43e-47	-0.335000	5.66e-45
Budding and maturation of HIV virion	28	2.17e-03	-0.335000	4.84e-03
Deubiquitination	249	8.67e-20	-0.334000	3.21e-18
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	36	5.40e-04	-0.333000	1.44e-03
Platelet activation, signaling and aggregation	232	2.09e-18	-0.333000	6.59e-17
Telomere Extension By Telomerase	23	5.71e-03	-0.333000	1.13e-02
Post-translational protein modification	1276	2.61e-90	-0.333000	1.94e-87
Mitochondrial tRNA aminoacylation	21	8.39e-03	-0.332000	1.57e-02
FOXO-mediated transcription of cell death genes	15	2.59e-02	-0.332000	4.24e-02
Activation of BH3-only proteins	29	1.97e-03	-0.332000	4.44e-03
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	75	6.62e-07	-0.332000	3.41e-06
Interleukin-12 family signaling	51	4.22e-05	-0.331000	1.45e-04
PCP/CE pathway	90	5.56e-08	-0.331000	3.84e-07
Lysosphingolipid and LPA receptors	12	4.72e-02	-0.331000	7.12e-02
Advanced glycosylation endproduct receptor signaling	11	5.75e-02	-0.331000	8.50e-02
SARS-CoV-1 Infection	50	5.20e-05	-0.331000	1.74e-04
RHOBTB2 GTPase cycle	23	6.06e-03	-0.331000	1.19e-02
Interferon Signaling	178	2.97e-14	-0.330000	6.20e-13
Signaling by Receptor Tyrosine Kinases	480	2.16e-35	-0.330000	2.13e-33
Toll-like Receptor Cascades	142	1.20e-11	-0.329000	1.53e-10
G beta:gamma signalling through CDC42	18	1.56e-02	-0.329000	2.71e-02
Metabolism of non-coding RNA	53	3.52e-05	-0.328000	1.24e-04
snRNP Assembly	53	3.52e-05	-0.328000	1.24e-04
O-linked glycosylation of mucins	50	6.09e-05	-0.328000	2.00e-04
Signaling by the B Cell Receptor (BCR)	105	6.48e-09	-0.328000	4.93e-08
Negative regulation of FGFR1 signaling	30	1.92e-03	-0.327000	4.35e-03
RNA polymerase II transcribes snRNA genes	71	1.90e-06	-0.327000	8.76e-06
RHO GTPase cycle	437	7.51e-32	-0.327000	6.18e-30
Caspase-mediated cleavage of cytoskeletal proteins	12	5.01e-02	-0.327000	7.49e-02
Intrinsic Pathway for Apoptosis	53	3.91e-05	-0.326000	1.36e-04
Ca2+ pathway	60	1.23e-05	-0.326000	4.71e-05
FOXO-mediated transcription	59	1.50e-05	-0.326000	5.69e-05
Regulation of FZD by ubiquitination	20	1.17e-02	-0.326000	2.11e-02
TRAF3-dependent IRF activation pathway	14	3.49e-02	-0.326000	5.51e-02
Dermatan sulfate biosynthesis	11	6.17e-02	-0.325000	9.08e-02
NOTCH2 intracellular domain regulates transcription	12	5.10e-02	-0.325000	7.61e-02
HCMV Early Events	81	4.12e-07	-0.325000	2.19e-06
Elastic fibre formation	36	7.34e-04	-0.325000	1.89e-03
Degradation of beta-catenin by the destruction complex	83	3.02e-07	-0.325000	1.65e-06
Class I peroxisomal membrane protein import	19	1.42e-02	-0.325000	2.51e-02
Activation of the TFAP2 (AP-2) family of transcription factors	11	6.23e-02	-0.325000	9.13e-02
Carnitine metabolism	11	6.31e-02	-0.324000	9.22e-02
Protein methylation	15	3.00e-02	-0.324000	4.83e-02
Downregulation of ERBB2:ERBB3 signaling	13	4.37e-02	-0.323000	6.72e-02
Defects in vitamin and cofactor metabolism	21	1.05e-02	-0.322000	1.91e-02
Mitotic Metaphase and Anaphase	229	4.10e-17	-0.322000	1.15e-15
Beta-catenin independent WNT signaling	142	3.64e-11	-0.321000	4.32e-10
Mitotic Anaphase	228	6.44e-17	-0.321000	1.74e-15
Regulation of BACH1 activity	11	6.57e-02	-0.320000	9.57e-02
Estrogen-dependent gene expression	110	6.38e-09	-0.320000	4.87e-08
RHOA GTPase cycle	146	2.66e-11	-0.319000	3.20e-10
MAPK family signaling cascades	302	1.29e-21	-0.319000	5.32e-20
Glutathione conjugation	30	2.51e-03	0.319000	5.52e-03
MAPK6/MAPK4 signaling	87	3.00e-07	-0.318000	1.65e-06
Signaling by PDGF	53	6.43e-05	-0.317000	2.10e-04
Interleukin-20 family signaling	19	1.67e-02	-0.317000	2.87e-02
Metabolism of carbohydrates	266	4.94e-19	-0.317000	1.75e-17
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	5.02e-08	0.317000	3.49e-07
BBSome-mediated cargo-targeting to cilium	21	1.23e-02	-0.315000	2.21e-02
SUMOylation of intracellular receptors	28	3.92e-03	-0.315000	8.10e-03
Diseases associated with visual transduction	10	8.48e-02	0.315000	1.19e-01
Diseases of the neuronal system	10	8.48e-02	0.315000	1.19e-01
Retinoid cycle disease events	10	8.48e-02	0.315000	1.19e-01
Uptake and actions of bacterial toxins	29	3.36e-03	-0.315000	7.11e-03
Adaptive Immune System	657	3.14e-43	-0.314000	4.24e-41
RAC1 GTPase cycle	178	5.07e-13	-0.313000	8.09e-12
MAP2K and MAPK activation	36	1.15e-03	-0.313000	2.82e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	1.12e-02	-0.312000	2.04e-02
Purine salvage	12	6.13e-02	-0.312000	9.03e-02
MTOR signalling	40	6.53e-04	-0.311000	1.71e-03
SUMOylation of transcription cofactors	44	3.51e-04	-0.311000	9.94e-04
Factors involved in megakaryocyte development and platelet production	119	4.38e-09	-0.311000	3.42e-08
Phospholipase C-mediated cascade; FGFR4	12	6.20e-02	0.311000	9.11e-02
Negative regulators of DDX58/IFIH1 signaling	35	1.45e-03	-0.311000	3.47e-03
Activated NOTCH1 Transmits Signal to the Nucleus	31	2.79e-03	-0.310000	6.03e-03
PKMTs methylate histone lysines	45	3.27e-04	-0.309000	9.35e-04
Translesion synthesis by POLK	17	2.72e-02	-0.309000	4.42e-02
Cargo trafficking to the periciliary membrane	47	2.51e-04	-0.309000	7.33e-04
Deactivation of the beta-catenin transactivating complex	41	6.60e-04	-0.307000	1.73e-03
Deadenylation-dependent mRNA decay	53	1.08e-04	-0.307000	3.45e-04
Common Pathway of Fibrin Clot Formation	14	4.69e-02	-0.307000	7.08e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	3.14e-07	0.307000	1.71e-06
Metabolism of fat-soluble vitamins	36	1.45e-03	-0.307000	3.47e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	125	3.14e-09	0.307000	2.53e-08
Hemostasis	505	3.66e-32	-0.306000	3.19e-30
Regulation of PTEN gene transcription	61	3.90e-05	-0.304000	1.36e-04
Vasopressin regulates renal water homeostasis via Aquaporins	36	1.58e-03	-0.304000	3.74e-03
HCMV Infection	105	7.34e-08	-0.304000	4.84e-07
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	28	5.41e-03	-0.304000	1.08e-02
Interleukin-12 signaling	43	5.72e-04	-0.304000	1.52e-03
Formation of a pool of free 40S subunits	99	1.78e-07	0.303000	1.07e-06
Metabolism of steroids	138	9.30e-10	-0.302000	8.47e-09
eNOS activation	11	8.35e-02	-0.301000	1.18e-01
C-type lectin receptors (CLRs)	125	5.80e-09	-0.301000	4.48e-08
The NLRP3 inflammasome	15	4.34e-02	-0.301000	6.68e-02
Synthesis of very long-chain fatty acyl-CoAs	22	1.46e-02	-0.301000	2.58e-02
RHOBTB3 ATPase cycle	10	1.00e-01	-0.300000	1.38e-01
Signaling by FGFR1	47	3.66e-04	-0.300000	1.03e-03
Mitochondrial calcium ion transport	22	1.47e-02	-0.300000	2.61e-02
Mitotic Spindle Checkpoint	109	5.95e-08	-0.300000	3.94e-07
HDR through MMEJ (alt-NHEJ)	10	1.00e-01	-0.300000	1.39e-01
Interleukin receptor SHC signaling	22	1.50e-02	-0.300000	2.64e-02
MAPK1/MAPK3 signaling	263	5.79e-17	-0.299000	1.59e-15
SUMOylation	171	1.55e-11	-0.299000	1.96e-10
Platelet homeostasis	76	6.93e-06	-0.298000	2.82e-05
PTEN Regulation	140	1.10e-09	-0.298000	9.75e-09
Defective CFTR causes cystic fibrosis	58	8.69e-05	-0.298000	2.79e-04
Chaperonin-mediated protein folding	85	2.07e-06	-0.298000	9.47e-06
Chondroitin sulfate/dermatan sulfate metabolism	49	3.12e-04	-0.298000	8.97e-04
Signaling by Nuclear Receptors	245	1.02e-15	-0.297000	2.36e-14
Downstream TCR signaling	89	1.24e-06	-0.297000	5.96e-06
Myogenesis	25	1.02e-02	-0.297000	1.87e-02
Cellular response to hypoxia	73	1.15e-05	-0.297000	4.45e-05
FCERI mediated NF-kB activation	76	7.65e-06	-0.297000	3.06e-05
TCF dependent signaling in response to WNT	187	2.49e-12	-0.297000	3.48e-11
Molecules associated with elastic fibres	27	7.64e-03	-0.297000	1.46e-02
Elevation of cytosolic Ca2+ levels	13	6.42e-02	-0.296000	9.38e-02
Ub-specific processing proteases	177	1.02e-11	-0.296000	1.34e-10
Neddylation	223	2.36e-14	-0.296000	5.00e-13
Regulation of pyruvate dehydrogenase (PDH) complex	15	4.76e-02	-0.295000	7.16e-02
Signaling by ERBB4	53	2.01e-04	-0.295000	5.99e-04
Notch-HLH transcription pathway	28	6.87e-03	-0.295000	1.33e-02
Recognition of DNA damage by PCNA-containing replication complex	30	5.21e-03	-0.295000	1.05e-02
Downstream signaling events of B Cell Receptor (BCR)	79	6.43e-06	-0.293000	2.67e-05
Rap1 signalling	15	4.99e-02	-0.292000	7.48e-02
FGFR1 mutant receptor activation	29	6.53e-03	-0.292000	1.27e-02
IKK complex recruitment mediated by RIP1	22	1.79e-02	-0.292000	3.06e-02
Aquaporin-mediated transport	38	1.87e-03	-0.291000	4.27e-03
Downregulation of ERBB2 signaling	29	6.61e-03	-0.291000	1.29e-02
Sphingolipid metabolism	83	4.46e-06	-0.291000	1.92e-05
Translesion synthesis by REV1	16	4.40e-02	-0.291000	6.75e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	11	9.49e-02	-0.291000	1.32e-01
Receptor-type tyrosine-protein phosphatases	19	2.89e-02	-0.290000	4.67e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	31	5.28e-03	-0.289000	1.06e-02
Effects of PIP2 hydrolysis	24	1.42e-02	-0.289000	2.51e-02
RAF/MAP kinase cascade	257	1.40e-15	-0.289000	3.19e-14
Signaling by FGFR1 in disease	36	2.71e-03	-0.289000	5.90e-03
Separation of Sister Chromatids	168	1.03e-10	-0.289000	1.10e-09
Transcription of the HIV genome	69	3.38e-05	-0.289000	1.20e-04
Chaperone Mediated Autophagy	17	3.98e-02	-0.288000	6.20e-02
Regulation of TP53 Activity	156	5.24e-10	-0.288000	4.98e-09
Cell-cell junction organization	54	2.52e-04	-0.288000	7.34e-04
Integration of energy metabolism	98	8.82e-07	-0.287000	4.40e-06
SUMO E3 ligases SUMOylate target proteins	165	1.98e-10	-0.287000	2.01e-09
Semaphorin interactions	61	1.08e-04	-0.286000	3.45e-04
RHO GTPases Activate NADPH Oxidases	22	2.02e-02	-0.286000	3.41e-02
Nonhomologous End-Joining (NHEJ)	43	1.18e-03	-0.286000	2.88e-03
Ion homeostasis	47	7.03e-04	-0.286000	1.82e-03
TCR signaling	110	2.34e-07	-0.285000	1.34e-06
Signaling by Interleukins	394	2.09e-22	-0.285000	9.99e-21
Regulation of TP53 Activity through Acetylation	29	8.04e-03	-0.284000	1.53e-02
Transcriptional regulation by RUNX2	116	1.22e-07	-0.284000	7.67e-07
Regulation of HMOX1 expression and activity	63	9.63e-05	-0.284000	3.08e-04
Signal Transduction	2202	0.00e+00	-0.284000	0.00e+00
Signaling by FGFR4	38	2.47e-03	-0.284000	5.45e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	5.76e-02	-0.283000	8.50e-02
Cytokine Signaling in Immune system	617	2.37e-33	-0.283000	2.20e-31
Apoptosis	171	1.80e-10	-0.282000	1.85e-09
Platelet Aggregation (Plug Formation)	33	4.98e-03	-0.282000	1.01e-02
Negative regulation of FGFR4 signaling	28	9.81e-03	-0.282000	1.83e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	36	3.42e-03	-0.282000	7.21e-03
Activated NTRK2 signals through FRS2 and FRS3	11	1.06e-01	-0.282000	1.45e-01
G beta:gamma signalling through PI3Kgamma	23	1.94e-02	-0.282000	3.31e-02
Apoptotic factor-mediated response	19	3.37e-02	-0.281000	5.34e-02
G-protein beta:gamma signalling	30	7.69e-03	-0.281000	1.47e-02
Respiratory electron transport	103	8.33e-07	0.281000	4.17e-06
Metabolism of amine-derived hormones	12	9.21e-02	0.281000	1.29e-01
Platelet degranulation	112	2.93e-07	-0.280000	1.62e-06
Interleukin-1 family signaling	130	3.43e-08	-0.280000	2.43e-07
AKT phosphorylates targets in the nucleus	10	1.26e-01	-0.279000	1.70e-01
Regulation of RUNX3 expression and activity	54	3.85e-04	-0.279000	1.07e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	34	4.88e-03	-0.279000	9.89e-03
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	5.36e-02	-0.279000	7.98e-02
Digestion and absorption	13	8.20e-02	0.279000	1.17e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	1.80e-03	-0.278000	4.13e-03
HIV Transcription Elongation	42	1.80e-03	-0.278000	4.13e-03
Tat-mediated elongation of the HIV-1 transcript	42	1.80e-03	-0.278000	4.13e-03
Pausing and recovery of Tat-mediated HIV elongation	30	8.35e-03	-0.278000	1.57e-02
Tat-mediated HIV elongation arrest and recovery	30	8.35e-03	-0.278000	1.57e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	33	5.83e-03	-0.277000	1.15e-02
Immune System	1673	7.80e-81	-0.277000	3.86e-78
RUNX2 regulates osteoblast differentiation	23	2.18e-02	-0.276000	3.64e-02
Signaling by ERBB2 TMD/JMD mutants	22	2.48e-02	-0.276000	4.08e-02
Signaling by NOTCH3	47	1.06e-03	-0.276000	2.62e-03
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.20e-02	-0.276000	3.68e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	21	2.89e-02	-0.275000	4.67e-02
IL-6-type cytokine receptor ligand interactions	16	5.67e-02	-0.275000	8.42e-02
Other semaphorin interactions	16	5.71e-02	-0.275000	8.45e-02
Glyoxylate metabolism and glycine degradation	26	1.54e-02	-0.274000	2.69e-02
Lewis blood group biosynthesis	15	6.69e-02	-0.273000	9.72e-02
Role of phospholipids in phagocytosis	23	2.35e-02	-0.273000	3.89e-02
Transport of vitamins, nucleosides, and related molecules	37	4.07e-03	-0.273000	8.38e-03
Regulation of PTEN stability and activity	67	1.13e-04	-0.273000	3.59e-04
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	6.76e-02	-0.272000	9.79e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	6.76e-02	-0.272000	9.79e-02
Asymmetric localization of PCP proteins	62	2.06e-04	-0.272000	6.13e-04
Formation of HIV elongation complex in the absence of HIV Tat	44	1.77e-03	-0.272000	4.10e-03
Negative regulation of FGFR2 signaling	30	9.86e-03	-0.272000	1.83e-02
Programmed Cell Death	197	4.98e-11	-0.271000	5.73e-10
DDX58/IFIH1-mediated induction of interferon-alpha/beta	67	1.25e-04	-0.271000	3.86e-04
HIV elongation arrest and recovery	32	8.21e-03	-0.270000	1.55e-02
Pausing and recovery of HIV elongation	32	8.21e-03	-0.270000	1.55e-02
Retinoid metabolism and transport	32	8.53e-03	-0.269000	1.60e-02
Disorders of Developmental Biology	13	9.36e-02	-0.269000	1.30e-01
Disorders of Nervous System Development	13	9.36e-02	-0.269000	1.30e-01
Loss of function of MECP2 in Rett syndrome	13	9.36e-02	-0.269000	1.30e-01
Pervasive developmental disorders	13	9.36e-02	-0.269000	1.30e-01
Neutrophil degranulation	426	1.69e-21	-0.268000	6.79e-20
Iron uptake and transport	56	5.23e-04	-0.268000	1.40e-03
Response to elevated platelet cytosolic Ca2+	117	5.57e-07	-0.268000	2.90e-06
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	7.26e-02	-0.268000	1.04e-01
Regulation of RUNX2 expression and activity	70	1.09e-04	-0.267000	3.45e-04
Leishmania infection	194	1.31e-10	-0.267000	1.38e-09
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58	4.29e-04	-0.267000	1.18e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants	58	4.29e-04	-0.267000	1.18e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	58	4.29e-04	-0.267000	1.18e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer	58	4.29e-04	-0.267000	1.18e-03
Signaling by NOTCH1 in Cancer	58	4.29e-04	-0.267000	1.18e-03
tRNA Aminoacylation	42	2.75e-03	-0.267000	5.97e-03
Vitamin D (calciferol) metabolism	10	1.45e-01	-0.266000	1.91e-01
Interleukin-4 and Interleukin-13 signaling	95	7.29e-06	-0.266000	2.94e-05
Cyclin A:Cdk2-associated events at S phase entry	85	2.22e-05	-0.266000	8.16e-05
Activation of NF-kappaB in B cells	65	2.08e-04	-0.266000	6.18e-04
M Phase	371	1.50e-18	-0.265000	4.83e-17
Regulation of RAS by GAPs	64	2.46e-04	-0.265000	7.19e-04
Transcriptional Regulation by MECP2	56	6.03e-04	-0.265000	1.59e-03
DNA Double Strand Break Response	52	9.55e-04	-0.265000	2.41e-03
Neurotoxicity of clostridium toxins	10	1.47e-01	0.265000	1.93e-01
Oncogene Induced Senescence	31	1.09e-02	-0.264000	1.97e-02
Phospholipid metabolism	191	2.89e-10	-0.264000	2.84e-09
Triglyceride metabolism	27	1.78e-02	-0.264000	3.04e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	58	5.27e-04	-0.263000	1.41e-03
NOD1/2 Signaling Pathway	32	1.04e-02	-0.262000	1.90e-02
Peroxisomal protein import	60	4.55e-04	-0.262000	1.24e-03
tRNA processing in the nucleus	59	5.10e-04	-0.262000	1.37e-03
Pyruvate metabolism	29	1.48e-02	-0.262000	2.61e-02
Cell surface interactions at the vascular wall	105	3.71e-06	-0.261000	1.63e-05
Chondroitin sulfate biosynthesis	20	4.32e-02	-0.261000	6.67e-02
SCF-beta-TrCP mediated degradation of Emi1	53	1.01e-03	-0.261000	2.53e-03
Mitotic Prometaphase	186	8.40e-10	-0.261000	7.69e-09
Selenoamino acid metabolism	115	1.39e-06	0.260000	6.63e-06
Protein folding	91	1.79e-05	-0.260000	6.67e-05
GLI3 is processed to GLI3R by the proteasome	57	6.87e-04	-0.260000	1.79e-03
Late endosomal microautophagy	29	1.55e-02	-0.260000	2.70e-02
Interferon gamma signaling	82	4.78e-05	-0.260000	1.62e-04
Assembly of active LPL and LIPC lipase complexes	15	8.20e-02	-0.259000	1.17e-01
Metabolism of proteins	1754	2.75e-74	-0.259000	8.15e-72
SLC transporter disorders	82	4.99e-05	-0.259000	1.67e-04
Metabolism of nitric oxide: NOS3 activation and regulation	15	8.27e-02	-0.259000	1.17e-01
Insulin receptor signalling cascade	49	1.74e-03	-0.259000	4.03e-03
Cyclin E associated events during G1/S transition	83	4.72e-05	-0.258000	1.61e-04
RHO GTPases activate PKNs	53	1.17e-03	-0.258000	2.88e-03
Hh mutants are degraded by ERAD	54	1.06e-03	-0.257000	2.63e-03
G-protein activation	20	4.62e-02	-0.257000	7.03e-02
Activation of GABAB receptors	37	6.85e-03	-0.257000	1.33e-02
GABA B receptor activation	37	6.85e-03	-0.257000	1.33e-02
Nuclear Receptor transcription pathway	47	2.32e-03	-0.257000	5.14e-03
NOTCH4 Intracellular Domain Regulates Transcription	20	4.73e-02	-0.256000	7.14e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	51	1.56e-03	-0.256000	3.70e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	4.76e-02	-0.256000	7.16e-02
CDC42 GTPase cycle	153	4.93e-08	-0.255000	3.45e-07
Signaling by NTRK2 (TRKB)	24	3.05e-02	-0.255000	4.89e-02
Prefoldin mediated transfer of substrate to CCT/TriC	27	2.21e-02	-0.254000	3.69e-02
Innate Immune System	872	1.49e-37	-0.254000	1.70e-35
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	51	1.70e-03	-0.254000	3.96e-03
Formation of apoptosome	11	1.45e-01	-0.254000	1.90e-01
Regulation of the apoptosome activity	11	1.45e-01	-0.254000	1.90e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	7.91e-02	0.254000	1.13e-01
Triglyceride catabolism	18	6.32e-02	-0.253000	9.23e-02
Disease	1469	3.79e-60	-0.253000	8.03e-58
Transcriptional Regulation by TP53	357	2.06e-16	-0.253000	5.09e-15
Dectin-1 mediated noncanonical NF-kB signaling	59	7.93e-04	-0.252000	2.03e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	1.17e-01	-0.251000	1.59e-01
Chromatin modifying enzymes	225	8.22e-11	-0.251000	8.90e-10
Chromatin organization	225	8.22e-11	-0.251000	8.90e-10
HCMV Late Events	77	1.41e-04	-0.251000	4.33e-04
E2F mediated regulation of DNA replication	22	4.20e-02	-0.250000	6.51e-02
NIK–>noncanonical NF-kB signaling	57	1.08e-03	-0.250000	2.67e-03
Defects in cobalamin (B12) metabolism	13	1.18e-01	-0.250000	1.60e-01
Regulation of APC/C activators between G1/S and early anaphase	79	1.23e-04	-0.250000	3.84e-04
Cytosolic tRNA aminoacylation	24	3.44e-02	-0.249000	5.45e-02
FGFR4 ligand binding and activation	11	1.52e-01	0.249000	1.99e-01
Cell Cycle, Mitotic	513	3.63e-22	-0.249000	1.58e-20
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	5.70e-04	-0.249000	1.52e-03
Lysosome Vesicle Biogenesis	34	1.21e-02	-0.249000	2.17e-02
ECM proteoglycans	47	3.20e-03	-0.248000	6.79e-03
Hedgehog ligand biogenesis	63	6.77e-04	-0.247000	1.77e-03
Synaptic adhesion-like molecules	20	5.55e-02	-0.247000	8.24e-02
Polymerase switching on the C-strand of the telomere	26	2.90e-02	-0.247000	4.69e-02
Phospholipase C-mediated cascade; FGFR2	14	1.09e-01	0.247000	1.49e-01
DNA Damage Bypass	47	3.37e-03	-0.247000	7.12e-03
Infectious disease	745	1.00e-30	-0.247000	7.45e-29
Unwinding of DNA	12	1.41e-01	0.246000	1.86e-01
RUNX2 regulates bone development	30	2.03e-02	-0.245000	3.42e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	2.85e-02	-0.244000	4.62e-02
Metabolism of lipids	660	9.17e-27	-0.243000	5.67e-25
Formation of the Early Elongation Complex	33	1.55e-02	-0.243000	2.70e-02
Formation of the HIV-1 Early Elongation Complex	33	1.55e-02	-0.243000	2.70e-02
RNA Polymerase III Abortive And Retractive Initiation	41	7.23e-03	-0.242000	1.39e-02
RNA Polymerase III Transcription	41	7.23e-03	-0.242000	1.39e-02
ROS sensing by NFE2L2	55	1.91e-03	-0.242000	4.34e-03
TP53 Regulates Metabolic Genes	85	1.15e-04	-0.242000	3.64e-04
Degradation of GLI1 by the proteasome	57	1.65e-03	-0.241000	3.87e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.19e-01	-0.240000	1.61e-01
Pyroptosis	24	4.28e-02	-0.239000	6.61e-02
APC/C-mediated degradation of cell cycle proteins	86	1.30e-04	-0.239000	4.01e-04
Regulation of mitotic cell cycle	86	1.30e-04	-0.239000	4.01e-04
CRMPs in Sema3A signaling	16	9.86e-02	-0.238000	1.36e-01
Synthesis of PA	32	1.96e-02	-0.238000	3.33e-02
Hh mutants abrogate ligand secretion	57	1.85e-03	-0.238000	4.23e-03
SUMOylation of transcription factors	19	7.23e-02	-0.238000	1.04e-01
Neurotransmitter receptors and postsynaptic signal transmission	158	2.35e-07	-0.238000	1.35e-06
Sealing of the nuclear envelope (NE) by ESCRT-III	29	2.68e-02	-0.237000	4.37e-02
Degradation of GLI2 by the proteasome	57	1.96e-03	-0.237000	4.42e-03
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	3.06e-02	-0.236000	4.91e-02
Acyl chain remodelling of PG	12	1.58e-01	-0.235000	2.06e-01
Sema4D in semaphorin signaling	24	4.61e-02	-0.235000	7.02e-02
ER-Phagosome pathway	87	1.51e-04	-0.235000	4.59e-04
Cytoprotection by HMOX1	118	1.08e-05	-0.234000	4.20e-05
Regulation of TP53 Activity through Phosphorylation	91	1.11e-04	-0.234000	3.53e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	3.19e-03	-0.234000	6.78e-03
Phospholipase C-mediated cascade; FGFR3	11	1.80e-01	0.233000	2.32e-01
SCF(Skp2)-mediated degradation of p27/p21	60	1.79e-03	-0.233000	4.13e-03
Caspase activation via extrinsic apoptotic signalling pathway	25	4.38e-02	-0.233000	6.74e-02
Cytosolic sensors of pathogen-associated DNA	62	1.52e-03	-0.233000	3.62e-03
Signaling by FGFR in disease	59	2.00e-03	-0.232000	4.49e-03
mRNA Capping	29	3.05e-02	-0.232000	4.89e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	4.46e-02	-0.232000	6.82e-02
Cell Cycle Checkpoints	260	1.11e-10	-0.232000	1.18e-09
Phase 0 - rapid depolarisation	30	2.79e-02	0.232000	4.54e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	4.49e-02	-0.232000	6.86e-02
RNA Polymerase III Transcription Initiation	36	1.61e-02	-0.232000	2.79e-02
Signaling by NOTCH	196	2.38e-08	-0.231000	1.72e-07
Cytosolic iron-sulfur cluster assembly	13	1.49e-01	0.231000	1.96e-01
Assembly and cell surface presentation of NMDA receptors	25	4.61e-02	-0.230000	7.02e-02
Cell Cycle	637	2.35e-23	-0.230000	1.20e-21
Ubiquitin-dependent degradation of Cyclin D	50	4.84e-03	-0.230000	9.83e-03
Regulated Necrosis	51	4.52e-03	-0.230000	9.21e-03
Aggrephagy	21	6.84e-02	-0.230000	9.89e-02
Glycogen metabolism	26	4.27e-02	-0.230000	6.61e-02
Formation of Fibrin Clot (Clotting Cascade)	27	3.89e-02	-0.230000	6.07e-02
Presynaptic depolarization and calcium channel opening	11	1.87e-01	0.230000	2.40e-01
Signaling by FGFR	82	3.36e-04	-0.229000	9.57e-04
Regulation of mRNA stability by proteins that bind AU-rich elements	87	2.30e-04	-0.228000	6.77e-04
Formation of the beta-catenin:TCF transactivating complex	53	4.08e-03	-0.228000	8.38e-03
Diseases of glycosylation	131	6.64e-06	-0.228000	2.74e-05
Regulation of beta-cell development	31	2.86e-02	-0.227000	4.63e-02
Regulation of ornithine decarboxylase (ODC)	49	5.99e-03	-0.227000	1.18e-02
Disorders of transmembrane transporters	155	1.14e-06	-0.226000	5.55e-06
TP53 Regulates Transcription of Caspase Activators and Caspases	11	1.94e-01	0.226000	2.48e-01
Transcriptional regulation by small RNAs	69	1.18e-03	-0.226000	2.89e-03
STING mediated induction of host immune responses	15	1.31e-01	-0.225000	1.75e-01
Regulation of PLK1 Activity at G2/M Transition	87	3.02e-04	-0.224000	8.72e-04
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	30	3.37e-02	-0.224000	5.34e-02
GABA receptor activation	47	8.00e-03	-0.224000	1.52e-02
Death Receptor Signalling	138	6.00e-06	-0.223000	2.51e-05
Vpu mediated degradation of CD4	50	6.58e-03	-0.222000	1.28e-02
Regulation of Apoptosis	51	6.17e-03	-0.222000	1.21e-02
G2/M Transition	181	2.69e-07	-0.221000	1.50e-06
RIPK1-mediated regulated necrosis	27	4.65e-02	-0.221000	7.07e-02
Regulation of necroptotic cell death	27	4.65e-02	-0.221000	7.07e-02
Degradation of AXIN	53	5.35e-03	-0.221000	1.07e-02
Transcriptional regulation by RUNX1	189	1.58e-07	-0.221000	9.72e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	8.09e-03	-0.221000	1.53e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity	28	4.33e-02	-0.221000	6.67e-02
Trafficking of AMPA receptors	28	4.33e-02	-0.221000	6.67e-02
Mitochondrial biogenesis	91	2.97e-04	-0.219000	8.61e-04
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.30e-01	-0.219000	1.74e-01
Processive synthesis on the C-strand of the telomere	19	9.88e-02	-0.219000	1.36e-01
Formation of TC-NER Pre-Incision Complex	53	5.94e-03	-0.218000	1.17e-02
Translesion synthesis by POLI	17	1.20e-01	-0.218000	1.62e-01
Signaling by Insulin receptor	72	1.40e-03	-0.218000	3.37e-03
PI-3K cascade:FGFR3	16	1.32e-01	-0.217000	1.76e-01
Transport of bile salts and organic acids, metal ions and amine compounds	62	3.18e-03	-0.217000	6.78e-03
S Phase	160	2.32e-06	-0.216000	1.04e-05
Branched-chain amino acid catabolism	21	8.64e-02	-0.216000	1.21e-01
rRNA modification in the nucleus and cytosol	60	3.79e-03	-0.216000	7.89e-03
Collagen chain trimerization	42	1.55e-02	0.216000	2.70e-02
Polo-like kinase mediated events	16	1.37e-01	-0.215000	1.82e-01
p75 NTR receptor-mediated signalling	95	3.08e-04	-0.214000	8.86e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.26e-01	-0.214000	1.70e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.26e-01	-0.214000	1.70e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	7.10e-03	-0.214000	1.37e-02
Ion transport by P-type ATPases	49	9.79e-03	-0.213000	1.83e-02
Cellular response to chemical stress	148	7.82e-06	-0.213000	3.12e-05
TRAF6 mediated IRF7 activation	17	1.29e-01	-0.213000	1.73e-01
Sensory processing of sound by outer hair cells of the cochlea	43	1.62e-02	-0.212000	2.80e-02
Cell recruitment (pro-inflammatory response)	23	7.86e-02	-0.212000	1.12e-01
Purinergic signaling in leishmaniasis infection	23	7.86e-02	-0.212000	1.12e-01
IRF3-mediated induction of type I IFN	12	2.04e-01	-0.212000	2.58e-01
Mitotic G1 phase and G1/S transition	147	9.35e-06	-0.212000	3.72e-05
Mitotic G2-G2/M phases	183	7.78e-07	-0.212000	3.93e-06
Antigen processing-Cross presentation	100	2.57e-04	-0.211000	7.48e-04
Signaling by NOTCH2	33	3.56e-02	-0.211000	5.59e-02
Class C/3 (Metabotropic glutamate/pheromone receptors)	15	1.57e-01	0.211000	2.05e-01
G beta:gamma signalling through BTK	16	1.45e-01	-0.211000	1.90e-01
Metalloprotease DUBs	25	6.90e-02	-0.210000	9.97e-02
CDT1 association with the CDC6:ORC:origin complex	57	6.13e-03	-0.210000	1.20e-02
Transcription of E2F targets under negative control by DREAM complex	19	1.13e-01	-0.210000	1.55e-01
The activation of arylsulfatases	11	2.30e-01	-0.209000	2.85e-01
Signaling by NOTCH4	82	1.07e-03	-0.209000	2.65e-03
Signaling by FGFR2	68	2.91e-03	-0.209000	6.27e-03
SUMOylation of immune response proteins	11	2.32e-01	-0.208000	2.87e-01
TRAF6 mediated NF-kB activation	23	8.44e-02	-0.208000	1.19e-01
IRS-mediated signalling	44	1.71e-02	-0.208000	2.94e-02
Blood group systems biosynthesis	19	1.17e-01	-0.208000	1.59e-01
Signalling to RAS	20	1.08e-01	-0.207000	1.49e-01
G0 and Early G1	27	6.24e-02	-0.207000	9.14e-02
G2/M DNA damage checkpoint	69	3.07e-03	-0.206000	6.58e-03
Transcriptional regulation of testis differentiation	11	2.37e-01	-0.206000	2.91e-01
Developmental Biology	876	2.93e-25	-0.206000	1.61e-23
G beta:gamma signalling through PLC beta	18	1.31e-01	-0.206000	1.75e-01
Nervous system development	529	5.20e-16	-0.205000	1.22e-14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	2.57e-03	-0.205000	5.62e-03
PI-3K cascade:FGFR1	18	1.32e-01	-0.205000	1.76e-01
Formation of the cornified envelope	36	3.30e-02	-0.205000	5.26e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	2.12e-03	-0.205000	4.74e-03
Nucleotide Excision Repair	110	2.01e-04	-0.205000	5.99e-04
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	1.75e-03	-0.205000	4.07e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	110	2.09e-04	0.204000	6.20e-04
ERBB2 Activates PTK6 Signaling	13	2.02e-01	-0.204000	2.56e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	6.14e-02	-0.204000	9.04e-02
Dual incision in TC-NER	65	4.49e-03	-0.204000	9.19e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.30e-02	-0.203000	2.32e-02
p53-Independent DNA Damage Response	50	1.30e-02	-0.203000	2.32e-02
p53-Independent G1/S DNA damage checkpoint	50	1.30e-02	-0.203000	2.32e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	1.30e-03	-0.203000	3.16e-03
G1/S Transition	131	6.23e-05	-0.202000	2.04e-04
Activation of the AP-1 family of transcription factors	10	2.68e-01	-0.202000	3.25e-01
G alpha (q) signalling events	160	9.84e-06	-0.202000	3.89e-05
IGF1R signaling cascade	48	1.53e-02	-0.202000	2.69e-02
Butyrophilin (BTN) family interactions	10	2.68e-01	0.202000	3.25e-01
Regulation of gene expression in beta cells	14	1.91e-01	-0.202000	2.44e-01
Inflammasomes	20	1.18e-01	-0.202000	1.60e-01
Inositol phosphate metabolism	46	1.79e-02	-0.202000	3.06e-02
TNFR1-induced NFkappaB signaling pathway	26	7.72e-02	-0.200000	1.10e-01
TNF signaling	44	2.16e-02	-0.200000	3.62e-02
Glutathione synthesis and recycling	12	2.31e-01	0.200000	2.86e-01
Degradation of DVL	55	1.05e-02	-0.199000	1.91e-02
Cellular responses to stress	679	6.20e-19	-0.199000	2.09e-17
Interleukin-2 family signaling	36	3.87e-02	-0.199000	6.04e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	3.86e-03	-0.198000	8.03e-03
Gene Silencing by RNA	98	7.25e-04	-0.197000	1.88e-03
Gene expression (Transcription)	1392	1.80e-35	-0.197000	1.91e-33
Telomere C-strand (Lagging Strand) Synthesis	34	4.66e-02	-0.197000	7.07e-02
L13a-mediated translational silencing of Ceruloplasmin expression	109	3.75e-04	0.197000	1.05e-03
G1/S DNA Damage Checkpoints	64	6.46e-03	-0.197000	1.26e-02
Metabolism of polyamines	57	1.04e-02	-0.196000	1.91e-02
ABC transporters in lipid homeostasis	16	1.76e-01	0.196000	2.27e-01
Extension of Telomeres	51	1.57e-02	-0.195000	2.73e-02
Synthesis of PC	28	7.36e-02	-0.195000	1.06e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	74	3.68e-03	-0.195000	7.70e-03
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	16	1.77e-01	-0.195000	2.28e-01
Glycogen storage diseases	14	2.07e-01	-0.195000	2.61e-01
Regulation of insulin secretion	69	5.22e-03	-0.194000	1.05e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	9.28e-02	-0.194000	1.29e-01
IRS-related events triggered by IGF1R	47	2.16e-02	-0.194000	3.62e-02
CASP8 activity is inhibited	10	2.90e-01	-0.193000	3.47e-01
Dimerization of procaspase-8	10	2.90e-01	-0.193000	3.47e-01
Regulation by c-FLIP	10	2.90e-01	-0.193000	3.47e-01
PI3K Cascade	40	3.44e-02	-0.193000	5.45e-02
Protein localization	159	2.58e-05	-0.193000	9.37e-05
Cellular responses to stimuli	688	5.03e-18	-0.193000	1.52e-16
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	13	2.30e-01	-0.192000	2.85e-01
O-linked glycosylation	98	1.00e-03	-0.192000	2.50e-03
UCH proteinases	91	1.56e-03	-0.192000	3.70e-03
SRP-dependent cotranslational protein targeting to membrane	110	5.12e-04	0.192000	1.38e-03
Mismatch Repair	15	1.99e-01	-0.192000	2.53e-01
Tight junction interactions	23	1.12e-01	-0.192000	1.53e-01
FGFRL1 modulation of FGFR1 signaling	11	2.71e-01	-0.192000	3.28e-01
Sensory perception of taste	27	8.54e-02	0.191000	1.20e-01
Cristae formation	31	6.57e-02	0.191000	9.57e-02
Axon guidance	507	1.59e-13	-0.191000	2.88e-12
HIV Transcription Initiation	47	2.37e-02	-0.191000	3.91e-02
RNA Polymerase II HIV Promoter Escape	47	2.37e-02	-0.191000	3.91e-02
RNA Polymerase II Promoter Escape	47	2.37e-02	-0.191000	3.91e-02
RNA Polymerase II Transcription Initiation	47	2.37e-02	-0.191000	3.91e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	47	2.37e-02	-0.191000	3.91e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	47	2.37e-02	-0.191000	3.91e-02
Presynaptic function of Kainate receptors	19	1.51e-01	-0.190000	1.97e-01
Activated point mutants of FGFR2	13	2.36e-01	0.190000	2.90e-01
Peptide hormone metabolism	69	6.47e-03	-0.189000	1.26e-02
p53-Dependent G1 DNA Damage Response	62	1.01e-02	-0.189000	1.87e-02
p53-Dependent G1/S DNA damage checkpoint	62	1.01e-02	-0.189000	1.87e-02
Interleukin-10 signaling	36	5.00e-02	-0.189000	7.48e-02
ABC transporter disorders	73	5.44e-03	-0.188000	1.08e-02
RNA Pol II CTD phosphorylation and interaction with CE	27	9.07e-02	-0.188000	1.27e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	9.07e-02	-0.188000	1.27e-01
Long-term potentiation	22	1.27e-01	-0.188000	1.70e-01
Resolution of D-Loop Structures	33	6.25e-02	0.187000	9.15e-02
Defective GALNT12 causes CRCS1	10	3.05e-01	0.187000	3.62e-01
DNA Damage Recognition in GG-NER	38	4.68e-02	-0.186000	7.08e-02
Cap-dependent Translation Initiation	117	5.04e-04	0.186000	1.36e-03
Eukaryotic Translation Initiation	117	5.04e-04	0.186000	1.36e-03
Generic Transcription Pathway	1137	2.65e-26	-0.185000	1.57e-24
Sensory perception of sweet, bitter, and umami (glutamate) taste	22	1.32e-01	0.185000	1.76e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	49	2.50e-02	-0.185000	4.10e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	1.34e-01	-0.184000	1.79e-01
Transmission across Chemical Synapses	220	2.42e-06	-0.184000	1.09e-05
Orc1 removal from chromatin	69	8.23e-03	-0.184000	1.55e-02
RNA Polymerase II Transcription	1256	2.75e-28	-0.184000	1.93e-26
Hyaluronan metabolism	14	2.34e-01	-0.184000	2.89e-01
Processing of SMDT1	15	2.20e-01	-0.183000	2.75e-01
FGFR2 ligand binding and activation	15	2.20e-01	0.183000	2.75e-01
cGMP effects	14	2.37e-01	-0.183000	2.91e-01
Transcriptional regulation of granulopoiesis	52	2.28e-02	-0.182000	3.79e-02
Glycerophospholipid biosynthesis	114	7.67e-04	-0.182000	1.97e-03
Incretin synthesis, secretion, and inactivation	19	1.69e-01	-0.182000	2.19e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	1.21e-02	-0.181000	2.17e-02
RNA Polymerase III Transcription Termination	23	1.33e-01	-0.181000	1.77e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	8.80e-04	0.181000	2.23e-03
Nonsense-Mediated Decay (NMD)	113	8.80e-04	0.181000	2.23e-03
Phospholipase C-mediated cascade: FGFR1	13	2.59e-01	0.181000	3.15e-01
Tryptophan catabolism	13	2.60e-01	0.180000	3.16e-01
G1/S-Specific Transcription	29	9.31e-02	-0.180000	1.30e-01
Transport of small molecules	620	1.74e-14	-0.180000	3.74e-13
Amino acids regulate mTORC1	51	2.66e-02	-0.179000	4.34e-02
Pre-NOTCH Expression and Processing	71	9.00e-03	-0.179000	1.68e-02
Cellular Senescence	153	1.30e-04	-0.179000	4.01e-04
HATs acetylate histones	100	1.99e-03	-0.179000	4.47e-03
Extracellular matrix organization	263	7.17e-07	-0.177000	3.68e-06
APC-Cdc20 mediated degradation of Nek2A	26	1.18e-01	-0.177000	1.60e-01
ADORA2B mediated anti-inflammatory cytokines production	85	4.78e-03	-0.177000	9.72e-03
NRIF signals cell death from the nucleus	16	2.23e-01	-0.176000	2.79e-01
Neurotransmitter release cycle	48	3.50e-02	-0.176000	5.51e-02
Amine ligand-binding receptors	23	1.44e-01	-0.176000	1.90e-01
Sema4D induced cell migration and growth-cone collapse	20	1.76e-01	-0.175000	2.28e-01
RIP-mediated NFkB activation via ZBP1	16	2.26e-01	-0.175000	2.82e-01
Anti-inflammatory response favouring Leishmania parasite infection	112	1.42e-03	-0.174000	3.42e-03
Leishmania parasite growth and survival	112	1.42e-03	-0.174000	3.42e-03
Protein-protein interactions at synapses	80	7.04e-03	-0.174000	1.36e-02
FGFR2c ligand binding and activation	10	3.41e-01	0.174000	3.99e-01
Downstream signaling of activated FGFR3	23	1.49e-01	-0.174000	1.95e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	3.18e-01	-0.174000	3.75e-01
Aspartate and asparagine metabolism	10	3.42e-01	0.173000	4.00e-01
G2/M Checkpoints	140	3.95e-04	-0.173000	1.10e-03
Interferon alpha/beta signaling	58	2.25e-02	-0.173000	3.75e-02
Activation of Matrix Metalloproteinases	28	1.13e-01	-0.173000	1.54e-01
Diseases of metabolism	218	1.12e-05	-0.172000	4.33e-05
ZBP1(DAI) mediated induction of type I IFNs	19	1.93e-01	-0.172000	2.47e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	6.59e-02	-0.172000	9.59e-02
Negative regulation of NOTCH4 signaling	54	2.86e-02	-0.172000	4.63e-02
Synthesis of glycosylphosphatidylinositol (GPI)	18	2.08e-01	-0.172000	2.62e-01
Autodegradation of the E3 ubiquitin ligase COP1	49	3.80e-02	-0.171000	5.95e-02
Phosphorylation of CD3 and TCR zeta chains	17	2.24e-01	-0.170000	2.80e-01
Nucleotide-like (purinergic) receptors	11	3.31e-01	0.169000	3.88e-01
Prostacyclin signalling through prostacyclin receptor	17	2.27e-01	-0.169000	2.82e-01
ABC-family proteins mediated transport	98	3.79e-03	-0.169000	7.89e-03
Vif-mediated degradation of APOBEC3G	52	3.49e-02	-0.169000	5.51e-02
Processing of Intronless Pre-mRNAs	19	2.05e-01	-0.168000	2.59e-01
TICAM1-dependent activation of IRF3/IRF7	12	3.14e-01	-0.168000	3.70e-01
Nuclear signaling by ERBB4	29	1.18e-01	-0.168000	1.60e-01
Interconversion of nucleotide di- and triphosphates	29	1.18e-01	-0.168000	1.60e-01
Stabilization of p53	53	3.60e-02	-0.166000	5.65e-02
CDK-mediated phosphorylation and removal of Cdc6	71	1.55e-02	-0.166000	2.70e-02
Metabolism of Angiotensinogen to Angiotensins	12	3.19e-01	0.166000	3.76e-01
Plasma lipoprotein assembly, remodeling, and clearance	60	2.62e-02	-0.166000	4.28e-02
Regulation of innate immune responses to cytosolic DNA	14	2.83e-01	-0.166000	3.40e-01
Signaling by FGFR2 IIIa TM	19	2.12e-01	-0.165000	2.67e-01
p38MAPK events	13	3.05e-01	-0.164000	3.62e-01
Post-translational protein phosphorylation	88	7.71e-03	-0.164000	1.47e-02
Diseases of programmed cell death	62	2.54e-02	-0.164000	4.17e-02
Intrinsic Pathway of Fibrin Clot Formation	18	2.29e-01	-0.164000	2.84e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	32	1.09e-01	0.164000	1.49e-01
Smooth Muscle Contraction	31	1.15e-01	-0.163000	1.57e-01
Dual Incision in GG-NER	41	7.05e-02	-0.163000	1.02e-01
Unblocking of NMDA receptors, glutamate binding and activation	20	2.07e-01	-0.163000	2.61e-01
Nitric oxide stimulates guanylate cyclase	18	2.31e-01	-0.163000	2.86e-01
Collagen degradation	37	8.99e-02	-0.161000	1.26e-01
The canonical retinoid cycle in rods (twilight vision)	20	2.15e-01	0.160000	2.70e-01
Post-chaperonin tubulin folding pathway	20	2.16e-01	-0.160000	2.71e-01
Neuronal System	339	4.40e-07	-0.159000	2.32e-06
Striated Muscle Contraction	26	1.61e-01	0.159000	2.09e-01
AURKA Activation by TPX2	72	1.99e-02	-0.159000	3.37e-02
RMTs methylate histone arginines	43	7.20e-02	-0.159000	1.04e-01
Degradation of the extracellular matrix	97	7.10e-03	-0.158000	1.37e-02
Plasma lipoprotein clearance	30	1.35e-01	-0.158000	1.79e-01
Metabolism of vitamins and cofactors	171	3.71e-04	-0.158000	1.04e-03
FGFR3 mutant receptor activation	10	3.89e-01	0.157000	4.45e-01
Signaling by activated point mutants of FGFR3	10	3.89e-01	0.157000	4.45e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	2.13e-02	-0.157000	3.57e-02
Glycosphingolipid metabolism	41	8.38e-02	-0.156000	1.18e-01
Ras activation upon Ca2+ influx through NMDA receptor	20	2.27e-01	-0.156000	2.82e-01
The phototransduction cascade	26	1.69e-01	-0.156000	2.19e-01
Cross-presentation of soluble exogenous antigens (endosomes)	47	6.46e-02	-0.156000	9.42e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	13	3.35e-01	0.154000	3.93e-01
Sensory processing of sound by inner hair cells of the cochlea	57	4.46e-02	-0.154000	6.82e-02
Processing of DNA double-strand break ends	72	2.43e-02	-0.153000	3.99e-02
Signaling by Hedgehog	133	2.31e-03	-0.153000	5.12e-03
Signaling by FGFR3 in disease	20	2.43e-01	-0.151000	2.97e-01
Signaling by FGFR3 point mutants in cancer	20	2.43e-01	-0.151000	2.97e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	89	1.40e-02	-0.151000	2.49e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	36	1.18e-01	-0.151000	1.60e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	3.32e-01	-0.150000	3.89e-01
Senescence-Associated Secretory Phenotype (SASP)	72	2.83e-02	-0.149000	4.59e-02
Cellular response to starvation	150	1.71e-03	0.148000	3.99e-03
DNA Repair	298	1.06e-05	-0.148000	4.15e-05
Defective GALNT3 causes HFTC	10	4.18e-01	0.148000	4.74e-01
DNA Double-Strand Break Repair	140	2.49e-03	-0.148000	5.47e-03
TNFR2 non-canonical NF-kB pathway	92	1.44e-02	-0.148000	2.54e-02
Trafficking of GluR2-containing AMPA receptors	16	3.07e-01	-0.147000	3.64e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.04e-01	-0.147000	2.58e-01
Platelet Adhesion to exposed collagen	12	3.79e-01	-0.147000	4.37e-01
Activation of kainate receptors upon glutamate binding	28	1.79e-01	-0.147000	2.31e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	4.22e-01	-0.147000	4.77e-01
SLC-mediated transmembrane transport	207	3.02e-04	-0.146000	8.73e-04
Switching of origins to a post-replicative state	89	1.76e-02	-0.146000	3.02e-02
Degradation of cysteine and homocysteine	12	3.85e-01	0.145000	4.42e-01
APC/C:Cdc20 mediated degradation of Securin	66	4.21e-02	-0.145000	6.52e-02
Autodegradation of Cdh1 by Cdh1:APC/C	64	4.55e-02	-0.145000	6.94e-02
Sensory processing of sound	62	4.96e-02	-0.144000	7.43e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	3.51e-01	-0.144000	4.08e-01
Hedgehog ‘off’ state	96	1.50e-02	-0.144000	2.64e-02
Termination of O-glycan biosynthesis	17	3.05e-01	-0.144000	3.62e-01
Peroxisomal lipid metabolism	28	1.89e-01	-0.143000	2.42e-01
Insulin receptor recycling	24	2.24e-01	-0.143000	2.80e-01
TP53 Regulates Transcription of DNA Repair Genes	61	5.30e-02	-0.143000	7.89e-02
RNA Polymerase III Chain Elongation	18	2.94e-01	-0.143000	3.52e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.61e-01	-0.142000	3.16e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.61e-01	-0.142000	3.16e-01
Pregnenolone biosynthesis	11	4.18e-01	-0.141000	4.74e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	99	1.56e-02	-0.141000	2.71e-02
Basigin interactions	23	2.44e-01	-0.140000	2.98e-01
Inactivation, recovery and regulation of the phototransduction cascade	25	2.25e-01	-0.140000	2.81e-01
NR1H2 and NR1H3-mediated signaling	44	1.10e-01	-0.139000	1.50e-01
Dectin-2 family	16	3.36e-01	0.139000	3.93e-01
Recycling of bile acids and salts	13	3.86e-01	0.139000	4.42e-01
Downstream signaling of activated FGFR1	28	2.04e-01	-0.139000	2.58e-01
Fatty acid metabolism	153	3.25e-03	-0.138000	6.88e-03
Packaging Of Telomere Ends	25	2.34e-01	-0.138000	2.88e-01
PCNA-Dependent Long Patch Base Excision Repair	21	2.75e-01	-0.137000	3.32e-01
Detoxification of Reactive Oxygen Species	31	1.86e-01	-0.137000	2.39e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	4.13e-01	-0.137000	4.69e-01
Diseases of hemostasis	12	4.13e-01	-0.137000	4.69e-01
Endogenous sterols	23	2.57e-01	-0.136000	3.14e-01
Carboxyterminal post-translational modifications of tubulin	37	1.52e-01	-0.136000	1.98e-01
PI-3K cascade:FGFR2	19	3.05e-01	-0.136000	3.62e-01
PI-3K cascade:FGFR4	17	3.32e-01	-0.136000	3.89e-01
Dopamine Neurotransmitter Release Cycle	23	2.60e-01	-0.136000	3.16e-01
Diseases of mitotic cell cycle	38	1.48e-01	-0.136000	1.94e-01
Cell death signalling via NRAGE, NRIF and NADE	76	4.09e-02	-0.136000	6.36e-02
Repression of WNT target genes	14	3.80e-01	-0.135000	4.39e-01
Methylation	14	3.81e-01	0.135000	4.39e-01
Synthesis of IP2, IP, and Ins in the cytosol	14	3.82e-01	-0.135000	4.40e-01
Transcriptional Regulation by E2F6	34	1.74e-01	-0.135000	2.25e-01
Neurexins and neuroligins	51	9.61e-02	-0.135000	1.33e-01
Pre-NOTCH Transcription and Translation	55	8.51e-02	-0.134000	1.19e-01
Hedgehog ‘on’ state	84	3.35e-02	-0.134000	5.33e-02
Complement cascade	36	1.65e-01	0.134000	2.14e-01
TP53 Regulates Transcription of Cell Death Genes	43	1.29e-01	-0.134000	1.73e-01
TRP channels	20	3.01e-01	0.134000	3.58e-01
Chromosome Maintenance	110	1.58e-02	-0.133000	2.74e-02
Oxidative Stress Induced Senescence	83	3.65e-02	-0.133000	5.72e-02
Loss of Nlp from mitotic centrosomes	69	5.68e-02	-0.133000	8.42e-02
Loss of proteins required for interphase microtubule organization from the centrosome	69	5.68e-02	-0.133000	8.42e-02
GPCR downstream signalling	434	2.23e-06	-0.132000	1.01e-05
Base Excision Repair	64	6.75e-02	-0.132000	9.79e-02
Organelle biogenesis and maintenance	272	1.96e-04	-0.131000	5.87e-04
FGFR2 alternative splicing	26	2.49e-01	-0.131000	3.03e-01
Regulation of TLR by endogenous ligand	15	3.83e-01	0.130000	4.41e-01
Gluconeogenesis	29	2.28e-01	-0.129000	2.83e-01
Regulation of TNFR1 signaling	35	1.87e-01	-0.129000	2.40e-01
G alpha (s) signalling events	96	2.92e-02	-0.129000	4.70e-02
Signaling by GPCR	490	1.11e-06	-0.128000	5.43e-06
DSCAM interactions	10	4.84e-01	-0.128000	5.37e-01
Meiotic synapsis	50	1.18e-01	-0.128000	1.60e-01
Fanconi Anemia Pathway	36	1.85e-01	0.128000	2.38e-01
DNA Damage/Telomere Stress Induced Senescence	52	1.12e-01	-0.127000	1.53e-01
Early Phase of HIV Life Cycle	13	4.29e-01	-0.127000	4.83e-01
Transcriptional regulation of pluripotent stem cells	31	2.24e-01	-0.126000	2.80e-01
Acyl chain remodelling of PS	17	3.69e-01	-0.126000	4.26e-01
Visual phototransduction	74	6.10e-02	-0.126000	9.00e-02
NCAM signaling for neurite out-growth	56	1.04e-01	-0.126000	1.43e-01
Epigenetic regulation of gene expression	110	2.28e-02	-0.126000	3.79e-02
G alpha (i) signalling events	204	2.06e-03	-0.125000	4.62e-03
The citric acid (TCA) cycle and respiratory electron transport	174	4.52e-03	0.125000	9.21e-03
Signaling by FGFR2 in disease	39	1.79e-01	-0.124000	2.31e-01
Transport of Mature Transcript to Cytoplasm	82	5.30e-02	-0.124000	7.89e-02
RNA Polymerase I Transcription Initiation	47	1.43e-01	-0.123000	1.89e-01
Surfactant metabolism	21	3.28e-01	-0.123000	3.86e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	38	1.93e-01	-0.122000	2.46e-01
Mitochondrial translation initiation	90	4.80e-02	0.121000	7.20e-02
Condensation of Prophase Chromosomes	35	2.18e-01	-0.120000	2.73e-01
Metabolism	1899	2.72e-18	-0.120000	8.42e-17
Synthesis, secretion, and deacylation of Ghrelin	13	4.55e-01	-0.120000	5.10e-01
rRNA processing	214	2.54e-03	0.120000	5.55e-03
Heme degradation	11	4.93e-01	-0.119000	5.45e-01
Downstream signaling of activated FGFR2	26	2.92e-01	-0.119000	3.50e-01
Olfactory Signaling Pathway	24	3.13e-01	0.119000	3.70e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13	4.59e-01	0.119000	5.14e-01
Resolution of Abasic Sites (AP sites)	38	2.06e-01	-0.119000	2.61e-01
Downstream signaling of activated FGFR4	24	3.17e-01	-0.118000	3.74e-01
FCGR activation	10	5.20e-01	-0.117000	5.70e-01
Glucagon-type ligand receptors	25	3.10e-01	-0.117000	3.66e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	73	8.37e-02	-0.117000	1.18e-01
MicroRNA (miRNA) biogenesis	24	3.22e-01	-0.117000	3.79e-01
PD-1 signaling	18	3.91e-01	-0.117000	4.47e-01
Cleavage of the damaged pyrimidine	34	2.40e-01	-0.116000	2.94e-01
Depyrimidination	34	2.40e-01	-0.116000	2.94e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	34	2.40e-01	-0.116000	2.94e-01
Mitochondrial iron-sulfur cluster biogenesis	13	4.68e-01	-0.116000	5.21e-01
Interleukin-2 signaling	10	5.28e-01	-0.115000	5.78e-01
Interleukin-37 signaling	21	3.62e-01	-0.115000	4.19e-01
Intraflagellar transport	39	2.15e-01	0.115000	2.70e-01
Synthesis of DNA	118	3.12e-02	-0.115000	4.98e-02
Metabolism of water-soluble vitamins and cofactors	117	3.23e-02	-0.115000	5.15e-02
Mitochondrial translation termination	90	6.18e-02	0.114000	9.08e-02
Processing of Capped Intron-Containing Pre-mRNA	239	2.47e-03	-0.114000	5.45e-03
Recruitment of NuMA to mitotic centrosomes	80	7.95e-02	-0.113000	1.13e-01
ATF4 activates genes in response to endoplasmic reticulum stress	27	3.08e-01	0.113000	3.65e-01
Regulation of expression of SLITs and ROBOs	166	1.18e-02	0.113000	2.13e-02
Phase II - Conjugation of compounds	78	8.46e-02	0.113000	1.19e-01
FRS-mediated FGFR3 signaling	18	4.08e-01	-0.113000	4.65e-01
FRS-mediated FGFR1 signaling	20	3.85e-01	-0.112000	4.42e-01
Cleavage of the damaged purine	29	2.97e-01	-0.112000	3.54e-01
Depurination	29	2.97e-01	-0.112000	3.54e-01
Recognition and association of DNA glycosylase with site containing an affected purine	29	2.97e-01	-0.112000	3.54e-01
Metabolism of nucleotides	90	6.71e-02	-0.112000	9.73e-02
Biotin transport and metabolism	11	5.22e-01	-0.112000	5.72e-01
Deposition of new CENPA-containing nucleosomes at the centromere	45	1.97e-01	-0.111000	2.51e-01
Nucleosome assembly	45	1.97e-01	-0.111000	2.51e-01
Glutamate Neurotransmitter Release Cycle	24	3.47e-01	-0.111000	4.05e-01
Activation of HOX genes during differentiation	82	8.31e-02	-0.111000	1.18e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	82	8.31e-02	-0.111000	1.18e-01
Leading Strand Synthesis	14	4.74e-01	-0.111000	5.26e-01
Polymerase switching	14	4.74e-01	-0.111000	5.26e-01
Mitochondrial translation elongation	90	6.98e-02	0.111000	1.01e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	3.50e-01	-0.110000	4.08e-01
Transferrin endocytosis and recycling	30	3.01e-01	-0.109000	3.58e-01
Influenza Viral RNA Transcription and Replication	134	2.94e-02	0.109000	4.73e-02
Telomere Maintenance	85	8.26e-02	-0.109000	1.17e-01
MyD88 deficiency (TLR2/4)	15	4.73e-01	0.107000	5.26e-01
Lagging Strand Synthesis	20	4.09e-01	-0.107000	4.66e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	2.70e-01	-0.106000	3.27e-01
G alpha (12/13) signalling events	77	1.08e-01	-0.106000	1.48e-01
CS/DS degradation	14	4.96e-01	-0.105000	5.48e-01
HDR through Single Strand Annealing (SSA)	37	2.69e-01	-0.105000	3.25e-01
Regulation of TP53 Activity through Association with Co-factors	13	5.12e-01	-0.105000	5.63e-01
IRAK4 deficiency (TLR2/4)	16	4.67e-01	0.105000	5.21e-01
Fertilization	18	4.41e-01	0.105000	4.96e-01
SUMOylation of DNA methylation proteins	16	4.69e-01	-0.105000	5.22e-01
Assembly of the pre-replicative complex	91	8.46e-02	-0.105000	1.19e-01
Positive epigenetic regulation of rRNA expression	68	1.37e-01	-0.104000	1.82e-01
Synthesis of PE	12	5.36e-01	-0.103000	5.85e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	5.54e-01	-0.103000	6.01e-01
Hyaluronan uptake and degradation	10	5.73e-01	-0.103000	6.19e-01
Phosphorylation of the APC/C	20	4.28e-01	-0.102000	4.83e-01
RNA Polymerase I Promoter Opening	25	3.76e-01	0.102000	4.34e-01
Phase 4 - resting membrane potential	16	4.79e-01	-0.102000	5.32e-01
LGI-ADAM interactions	12	5.44e-01	0.101000	5.93e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	4.48e-01	-0.100000	5.04e-01
DNA Replication Pre-Initiation	108	7.13e-02	-0.100000	1.03e-01
RNA Polymerase I Transcription Termination	30	3.41e-01	-0.100000	3.99e-01
Class B/2 (Secretin family receptors)	73	1.40e-01	-0.099800	1.85e-01
Response of EIF2AK1 (HRI) to heme deficiency	15	5.04e-01	-0.099700	5.55e-01
mRNA 3’-end processing	57	1.97e-01	0.098700	2.51e-01
Biosynthesis of DHA-derived SPMs	14	5.23e-01	0.098700	5.72e-01
Mitochondrial translation	96	9.66e-02	0.098100	1.34e-01
Plasma lipoprotein remodeling	26	3.88e-01	-0.097800	4.45e-01
Signaling by Retinoic Acid	38	2.98e-01	-0.097600	3.55e-01
Formation of the ternary complex, and subsequently, the 43S complex	50	2.33e-01	0.097500	2.88e-01
Removal of the Flap Intermediate	14	5.29e-01	-0.097300	5.78e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	57	2.09e-01	-0.096200	2.63e-01
Major pathway of rRNA processing in the nucleolus and cytosol	180	2.62e-02	0.096000	4.28e-02
Ion channel transport	156	3.88e-02	-0.095800	6.06e-02
RNA Polymerase II Transcription Termination	66	1.78e-01	0.095700	2.30e-01
Centrosome maturation	81	1.38e-01	-0.095300	1.83e-01
Recruitment of mitotic centrosome proteins and complexes	81	1.38e-01	-0.095300	1.83e-01
Keratinization	64	1.90e-01	-0.094700	2.43e-01
Adrenaline,noradrenaline inhibits insulin secretion	26	4.06e-01	-0.094100	4.63e-01
Nucleotide salvage	21	4.56e-01	-0.094000	5.11e-01
Meiosis	76	1.60e-01	-0.093300	2.08e-01
Metabolism of RNA	678	3.35e-05	-0.093200	1.20e-04
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	5.47e-01	-0.093000	5.95e-01
Inhibition of DNA recombination at telomere	40	3.14e-01	-0.092000	3.70e-01
NRAGE signals death through JNK	59	2.25e-01	-0.091300	2.80e-01
Plasma lipoprotein assembly	13	5.69e-01	0.091300	6.15e-01
Mucopolysaccharidoses	11	6.01e-01	0.091200	6.48e-01
Biological oxidations	161	4.67e-02	0.090800	7.08e-02
Synthesis of bile acids and bile salts	31	3.82e-01	-0.090700	4.40e-01
SHC-mediated cascade:FGFR1	18	5.07e-01	-0.090300	5.59e-01
Base-Excision Repair, AP Site Formation	36	3.51e-01	-0.089800	4.08e-01
Processing of Capped Intronless Pre-mRNA	28	4.13e-01	-0.089400	4.69e-01
DNA methylation	27	4.25e-01	0.088700	4.79e-01
SHC-mediated cascade:FGFR3	16	5.42e-01	-0.088000	5.91e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	6.15e-01	-0.087600	6.61e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	4.98e-01	-0.087500	5.50e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	5.35e-01	0.086800	5.85e-01
Regulation of Complement cascade	29	4.18e-01	0.086800	4.74e-01
HDACs deacetylate histones	53	2.77e-01	-0.086400	3.33e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	6.37e-01	-0.086100	6.83e-01
Presynaptic phase of homologous DNA pairing and strand exchange	39	3.54e-01	-0.085800	4.10e-01
Lysine catabolism	12	6.08e-01	0.085600	6.55e-01
Cilium Assembly	181	4.68e-02	-0.085600	7.08e-02
Assembly of collagen fibrils and other multimeric structures	53	2.82e-01	0.085300	3.40e-01
Chemokine receptors bind chemokines	28	4.35e-01	0.085200	4.90e-01
Assembly of the ORC complex at the origin of replication	31	4.14e-01	-0.084700	4.70e-01
Post-translational modification: synthesis of GPI-anchored proteins	67	2.31e-01	-0.084600	2.86e-01
Defective C1GALT1C1 causes TNPS	11	6.27e-01	0.084600	6.73e-01
Activation of G protein gated Potassium channels	25	4.66e-01	-0.084300	5.20e-01
G protein gated Potassium channels	25	4.66e-01	-0.084300	5.20e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	25	4.66e-01	-0.084300	5.20e-01
Pyrimidine salvage	10	6.46e-01	0.084000	6.91e-01
Collagen biosynthesis and modifying enzymes	64	2.46e-01	0.083900	3.00e-01
Cardiac conduction	113	1.26e-01	-0.083400	1.69e-01
Activation of the pre-replicative complex	33	4.09e-01	-0.083100	4.66e-01
Activation of ATR in response to replication stress	37	3.86e-01	-0.082400	4.42e-01
ROS and RNS production in phagocytes	32	4.20e-01	-0.082400	4.75e-01
Metabolism of steroid hormones	29	4.50e-01	-0.080900	5.06e-01
Serotonin Neurotransmitter Release Cycle	18	5.57e-01	-0.079900	6.04e-01
Other interleukin signaling	23	5.10e-01	-0.079400	5.61e-01
Homologous DNA Pairing and Strand Exchange	42	3.77e-01	-0.078800	4.35e-01
Mitochondrial protein import	64	2.76e-01	-0.078700	3.33e-01
Amyloid fiber formation	60	2.92e-01	-0.078600	3.50e-01
Sulfur amino acid metabolism	26	4.89e-01	0.078300	5.41e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	6.68e-01	-0.078300	7.14e-01
Metabolism of cofactors	19	5.55e-01	-0.078200	6.02e-01
DNA Replication	151	1.01e-01	-0.077300	1.39e-01
Glycogen breakdown (glycogenolysis)	15	6.11e-01	-0.075800	6.57e-01
rRNA processing in the nucleus and cytosol	190	7.42e-02	0.075000	1.06e-01
FGFR1c ligand binding and activation	10	6.82e-01	0.074700	7.26e-01
Maturation of nucleoprotein	11	6.75e-01	-0.073100	7.20e-01
mRNA Splicing - Major Pathway	179	9.23e-02	-0.072900	1.29e-01
Metabolism of porphyrins	22	5.67e-01	-0.070500	6.13e-01
Integrin cell surface interactions	59	3.51e-01	-0.070200	4.08e-01
NCAM1 interactions	36	4.67e-01	0.070000	5.21e-01
Synthesis of IP3 and IP4 in the cytosol	25	5.46e-01	-0.069700	5.94e-01
Homology Directed Repair	111	2.06e-01	-0.069400	2.61e-01
Anchoring of the basal body to the plasma membrane	97	2.46e-01	-0.068200	3.00e-01
Nucleotide catabolism	31	5.15e-01	0.067500	5.66e-01
Diseases of carbohydrate metabolism	31	5.17e-01	-0.067300	5.67e-01
B-WICH complex positively regulates rRNA expression	53	3.98e-01	-0.067100	4.54e-01
Termination of translesion DNA synthesis	32	5.13e-01	-0.066800	5.64e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	6.35e-01	-0.066500	6.81e-01
Generation of second messenger molecules	28	5.45e-01	-0.066000	5.94e-01
CDC6 association with the ORC:origin complex	11	7.08e-01	0.065300	7.48e-01
FGFR3 ligand binding and activation	11	7.10e-01	0.064700	7.49e-01
FGFR3c ligand binding and activation	11	7.10e-01	0.064700	7.49e-01
mRNA Splicing - Minor Pathway	52	4.23e-01	0.064300	4.77e-01
Muscle contraction	164	1.58e-01	-0.063900	2.05e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	94	2.84e-01	-0.063800	3.42e-01
RNA Polymerase I Promoter Clearance	72	3.50e-01	-0.063700	4.08e-01
RNA Polymerase I Transcription	72	3.50e-01	-0.063700	4.08e-01
FGFR1 ligand binding and activation	13	6.93e-01	0.063200	7.35e-01
Metabolism of amino acids and derivatives	344	4.42e-02	0.063000	6.78e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	6.53e-01	-0.063000	6.99e-01
Negative epigenetic regulation of rRNA expression	71	3.68e-01	-0.061700	4.26e-01
TNFs bind their physiological receptors	23	6.11e-01	0.061300	6.57e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	5.37e-01	0.060200	5.86e-01
mRNA Splicing	187	1.56e-01	-0.060100	2.04e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	15	6.91e-01	0.059400	7.33e-01
Purine catabolism	17	6.75e-01	0.058700	7.20e-01
Nicotinamide salvaging	18	6.76e-01	0.057000	7.20e-01
Transcriptional Regulation by VENTX	38	5.52e-01	-0.055700	6.00e-01
Reproduction	94	3.54e-01	-0.055300	4.10e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	38	5.59e-01	-0.054800	6.05e-01
Biosynthesis of specialized proresolving mediators (SPMs)	15	7.13e-01	0.054800	7.52e-01
Acetylcholine binding and downstream events	10	7.66e-01	0.054400	8.01e-01
Postsynaptic nicotinic acetylcholine receptors	10	7.66e-01	0.054400	8.01e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	105	3.39e-01	-0.054000	3.96e-01
FRS-mediated FGFR2 signaling	21	6.69e-01	-0.053900	7.15e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	6.86e-01	-0.052100	7.30e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	21	6.97e-01	-0.049100	7.38e-01
Defective B3GALTL causes PpS	37	6.10e-01	0.048500	6.57e-01
Phase I - Functionalization of compounds	79	4.56e-01	0.048500	5.11e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	7.63e-01	-0.048400	7.99e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	7.31e-01	-0.048200	7.68e-01
Potassium Channels	86	4.46e-01	-0.047500	5.02e-01
Caspase activation via Death Receptors in the presence of ligand	15	7.52e-01	-0.047100	7.89e-01
Sensory Perception	182	2.75e-01	-0.046800	3.32e-01
FRS-mediated FGFR4 signaling	19	7.33e-01	-0.045200	7.70e-01
Xenobiotics	14	7.71e-01	0.044900	8.06e-01
SIRT1 negatively regulates rRNA expression	30	6.73e-01	-0.044500	7.19e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	87	4.86e-01	-0.043200	5.39e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	7.04e-01	0.043100	7.44e-01
Phenylalanine and tyrosine metabolism	10	8.16e-01	0.042400	8.42e-01
PERK regulates gene expression	32	6.87e-01	-0.041200	7.30e-01
Norepinephrine Neurotransmitter Release Cycle	17	7.71e-01	-0.040800	8.06e-01
Beta-oxidation of very long chain fatty acids	11	8.15e-01	0.040800	8.42e-01
Activation of Ca-permeable Kainate Receptor	10	8.26e-01	-0.040100	8.51e-01
Ionotropic activity of kainate receptors	10	8.26e-01	-0.040100	8.51e-01
Binding and Uptake of Ligands by Scavenger Receptors	33	6.92e-01	-0.039900	7.34e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	27	7.23e-01	-0.039400	7.61e-01
Diseases of DNA repair	34	6.95e-01	-0.038900	7.36e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	16	7.90e-01	-0.038400	8.21e-01
Apoptosis induced DNA fragmentation	12	8.18e-01	-0.038300	8.44e-01
NoRC negatively regulates rRNA expression	68	5.87e-01	-0.038000	6.34e-01
Stimuli-sensing channels	86	5.64e-01	-0.036000	6.10e-01
O-glycosylation of TSR domain-containing proteins	38	7.19e-01	0.033700	7.57e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	24	7.80e-01	-0.032900	8.12e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	24	7.80e-01	-0.032900	8.12e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	24	7.80e-01	-0.032900	8.12e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	24	7.80e-01	-0.032900	8.12e-01
Diseases of DNA Double-Strand Break Repair	24	7.80e-01	-0.032900	8.12e-01
Voltage gated Potassium channels	34	7.40e-01	-0.032900	7.77e-01
RNA Polymerase I Promoter Escape	53	6.82e-01	-0.032500	7.26e-01
PIWI-interacting RNA (piRNA) biogenesis	26	7.83e-01	0.031200	8.14e-01
Acyl chain remodelling of PC	21	8.06e-01	0.030900	8.35e-01
Nicotinate metabolism	29	7.80e-01	0.030000	8.12e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	13	8.62e-01	-0.027900	8.83e-01
Signaling by ROBO receptors	211	4.86e-01	-0.027800	5.39e-01
Processive synthesis on the lagging strand	15	8.54e-01	-0.027400	8.76e-01
SHC-mediated cascade:FGFR2	19	8.38e-01	-0.027000	8.62e-01
Diseases associated with the TLR signaling cascade	28	8.10e-01	-0.026300	8.37e-01
Diseases of Immune System	28	8.10e-01	-0.026300	8.37e-01
DNA strand elongation	32	8.02e-01	0.025500	8.32e-01
Defective pyroptosis	35	8.02e-01	-0.024500	8.32e-01
GPCR ligand binding	276	4.88e-01	-0.024200	5.40e-01
Antimicrobial peptides	26	8.34e-01	0.023700	8.58e-01
Interaction between L1 and Ankyrins	26	8.37e-01	0.023300	8.61e-01
Influenza Infection	154	6.24e-01	0.022800	6.71e-01
Cytochrome P450 - arranged by substrate type	47	8.04e-01	-0.020900	8.33e-01
Translation initiation complex formation	57	7.87e-01	-0.020700	8.18e-01
Metabolism of folate and pterines	16	8.89e-01	0.020100	9.09e-01
Eicosanoid ligand-binding receptors	13	9.00e-01	0.020100	9.19e-01
PRC2 methylates histones and DNA	35	8.40e-01	-0.019800	8.62e-01
tRNA processing	124	7.05e-01	-0.019700	7.45e-01
Ribosomal scanning and start codon recognition	57	8.04e-01	-0.019000	8.33e-01
Trafficking and processing of endosomal TLR	11	9.15e-01	0.018600	9.32e-01
tRNA modification in the nucleus and cytosol	43	8.40e-01	-0.017800	8.62e-01
Cytosolic sulfonation of small molecules	22	8.90e-01	-0.017000	9.10e-01
Translocation of ZAP-70 to Immunological synapse	14	9.18e-01	0.015900	9.33e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	9.21e-01	-0.015400	9.35e-01
Vitamin B5 (pantothenate) metabolism	16	9.16e-01	-0.015200	9.32e-01
Class A/1 (Rhodopsin-like receptors)	189	7.20e-01	-0.015100	7.58e-01
SLBP independent Processing of Histone Pre-mRNAs	10	9.36e-01	-0.014600	9.47e-01
Scavenging by Class A Receptors	18	9.16e-01	-0.014400	9.32e-01
SHC-mediated cascade:FGFR4	17	9.19e-01	-0.014200	9.34e-01
Amino acid transport across the plasma membrane	30	9.02e-01	0.013000	9.20e-01
Meiotic recombination	46	8.85e-01	0.012300	9.06e-01
Cellular hexose transport	18	9.31e-01	-0.011800	9.44e-01
Heme biosynthesis	13	9.43e-01	0.011400	9.53e-01
RA biosynthesis pathway	18	9.35e-01	-0.011100	9.46e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	9.50e-01	-0.010100	9.59e-01
Acyl chain remodelling of PI	12	9.55e-01	0.009380	9.62e-01
Peptide ligand-binding receptors	108	8.71e-01	0.009020	8.92e-01
FGFR2 mutant receptor activation	29	9.35e-01	-0.008810	9.46e-01
HDR through Homologous Recombination (HRR)	66	9.02e-01	0.008790	9.20e-01
Diseases associated with O-glycosylation of proteins	61	9.15e-01	-0.007930	9.32e-01
Inwardly rectifying K+ channels	31	9.40e-01	-0.007820	9.50e-01
Acyl chain remodelling of PE	21	9.56e-01	-0.006990	9.62e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	9.29e-01	-0.006810	9.42e-01
Metabolic disorders of biological oxidation enzymes	29	9.53e-01	0.006320	9.61e-01
Killing mechanisms	12	9.81e-01	-0.004030	9.83e-01
WNT5:FZD7-mediated leishmania damping	12	9.81e-01	-0.004030	9.83e-01
Collagen formation	85	9.50e-01	0.003920	9.59e-01
Regulation of TP53 Activity through Methylation	19	9.77e-01	0.003860	9.82e-01
Acetylcholine Neurotransmitter Release Cycle	16	9.80e-01	-0.003610	9.83e-01
Activation of SMO	18	9.80e-01	-0.003450	9.83e-01
GABA synthesis, release, reuptake and degradation	18	9.84e-01	-0.002730	9.85e-01
Arachidonic acid metabolism	42	9.79e-01	-0.002380	9.83e-01
Translation	293	9.54e-01	0.001960	9.61e-01
Bile acid and bile salt metabolism	38	9.92e-01	-0.000927	9.93e-01
Na+/Cl- dependent neurotransmitter transporters	11	9.99e-01	-0.000231	9.99e-01

---

Detailed Gene set reports

CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation

	137
set	CLEC7A (Dectin-1) induces NFAT activation
setSize	11
pANOVA	1.73e-06
s.dist	-0.833
p.adjustANOVA	8.11e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITPR1	-11274
NFATC3	-10658
PPP3R1	-10428
NFATC1	-10216
AHCYL1	-10203
CALM1	-9971
ITPR2	-9789
PPP3CB	-8357
NFATC2	-6641
ITPR3	-6102
PPP3CA	-5776

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITPR1	-11274
NFATC3	-10658
PPP3R1	-10428
NFATC1	-10216
AHCYL1	-10203
CALM1	-9971
ITPR2	-9789
PPP3CB	-8357
NFATC2	-6641
ITPR3	-6102
PPP3CA	-5776

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

	375
set	Establishment of Sister Chromatid Cohesion
setSize	11
pANOVA	2.26e-06
s.dist	-0.823
p.adjustANOVA	1.02e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WAPL	-10923
SMC1A	-10584
ESCO1	-10444
RAD21	-10425
PDS5A	-10262
STAG2	-10205
PDS5B	-8616
CDCA5	-7392
SMC3	-7292
ESCO2	-6117
STAG1	-5772

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WAPL	-10923
SMC1A	-10584
ESCO1	-10444
RAD21	-10425
PDS5A	-10262
STAG2	-10205
PDS5B	-8616
CDCA5	-7392
SMC3	-7292
ESCO2	-6117
STAG1	-5772

---

Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin

	207
set	Cohesin Loading onto Chromatin
setSize	10
pANOVA	7.27e-06
s.dist	-0.819
p.adjustANOVA	2.94e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WAPL	-10923
SMC1A	-10584
RAD21	-10425
PDS5A	-10262
STAG2	-10205
PDS5B	-8616
NIPBL	-8564
SMC3	-7292
MAU2	-5931
STAG1	-5772

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WAPL	-10923
SMC1A	-10584
RAD21	-10425
PDS5A	-10262
STAG2	-10205
PDS5B	-8616
NIPBL	-8564
SMC3	-7292
MAU2	-5931
STAG1	-5772

---

ERKs are inactivated

ERKs are inactivated

	360
set	ERKs are inactivated
setSize	13
pANOVA	4.28e-07
s.dist	-0.81
p.adjustANOVA	2.27e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
MAPK1	-10995
PPP2CB	-10791
DUSP7	-10486
DUSP6	-10231
DUSP4	-9894
PPP2CA	-9827
MAPK3	-8949
VRK3	-8340
DUSP3	-8063
PPP2R1A	-6397
PPP2R1B	-4990
MAPK7	-3522

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
MAPK1	-10995
PPP2CB	-10791
DUSP7	-10486
DUSP6	-10231
DUSP4	-9894
PPP2CA	-9827
MAPK3	-8949
VRK3	-8340
DUSP3	-8063
PPP2R1A	-6397
PPP2R1B	-4990
MAPK7	-3522

---

S33 mutants of beta-catenin aren’t phosphorylated

S33 mutants of beta-catenin aren’t phosphorylated

	1108
set	S33 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	5.89e-08
s.dist	-0.808
p.adjustANOVA	3.91e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

S37 mutants of beta-catenin aren’t phosphorylated

S37 mutants of beta-catenin aren’t phosphorylated

	1109
set	S37 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	5.89e-08
s.dist	-0.808
p.adjustANOVA	3.91e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

S45 mutants of beta-catenin aren’t phosphorylated

S45 mutants of beta-catenin aren’t phosphorylated

	1110
set	S45 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	5.89e-08
s.dist	-0.808
p.adjustANOVA	3.91e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Signaling by CTNNB1 phospho-site mutants

Signaling by CTNNB1 phospho-site mutants

	1180
set	Signaling by CTNNB1 phospho-site mutants
setSize	15
pANOVA	5.89e-08
s.dist	-0.808
p.adjustANOVA	3.91e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Signaling by GSK3beta mutants

Signaling by GSK3beta mutants

	1207
set	Signaling by GSK3beta mutants
setSize	15
pANOVA	5.89e-08
s.dist	-0.808
p.adjustANOVA	3.91e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

T41 mutants of beta-catenin aren’t phosphorylated

T41 mutants of beta-catenin aren’t phosphorylated

	1298
set	T41 mutants of beta-catenin aren’t phosphorylated
setSize	15
pANOVA	5.89e-08
s.dist	-0.808
p.adjustANOVA	3.91e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization

	506
set	Golgi Cisternae Pericentriolar Stack Reorganization
setSize	14
pANOVA	1.76e-07
s.dist	-0.806
p.adjustANOVA	1.07e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GORASP2	-11171
USO1	-11125
RAB1A	-11091
MAPK1	-10995
RAB1B	-10519
PLK1	-10443
RAB2A	-9543
GOLGA2	-8961
MAPK3	-8949
CCNB2	-7266
BLZF1	-7214
CDK1	-5951
GORASP1	-4207
CCNB1	-4104

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GORASP2	-11171
USO1	-11125
RAB1A	-11091
MAPK1	-10995
RAB1B	-10519
PLK1	-10443
RAB2A	-9543
GOLGA2	-8961
MAPK3	-8949
CCNB2	-7266
BLZF1	-7214
CDK1	-5951
GORASP1	-4207
CCNB1	-4104

---

APC truncation mutants have impaired AXIN binding

APC truncation mutants have impaired AXIN binding

	11
set	APC truncation mutants have impaired AXIN binding
setSize	14
pANOVA	2.29e-07
s.dist	-0.798
p.adjustANOVA	1.33e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

AXIN missense mutants destabilize the destruction complex

AXIN missense mutants destabilize the destruction complex

	24
set	AXIN missense mutants destabilize the destruction complex
setSize	14
pANOVA	2.29e-07
s.dist	-0.798
p.adjustANOVA	1.33e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Signaling by AMER1 mutants

Signaling by AMER1 mutants

	1173
set	Signaling by AMER1 mutants
setSize	14
pANOVA	2.29e-07
s.dist	-0.798
p.adjustANOVA	1.33e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Signaling by APC mutants

Signaling by APC mutants

	1174
set	Signaling by APC mutants
setSize	14
pANOVA	2.29e-07
s.dist	-0.798
p.adjustANOVA	1.33e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Signaling by AXIN mutants

Signaling by AXIN mutants

	1175
set	Signaling by AXIN mutants
setSize	14
pANOVA	2.29e-07
s.dist	-0.798
p.adjustANOVA	1.33e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Truncations of AMER1 destabilize the destruction complex

Truncations of AMER1 destabilize the destruction complex

	1414
set	Truncations of AMER1 destabilize the destruction complex
setSize	14
pANOVA	2.29e-07
s.dist	-0.798
p.adjustANOVA	1.33e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338

---

Signaling by Hippo

Signaling by Hippo

	1209
set	Signaling by Hippo
setSize	20
pANOVA	7.94e-10
s.dist	-0.794
p.adjustANOVA	7.32e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AMOTL2	-11160
AMOTL1	-10851
STK4	-10164
LATS1	-9809
AMOT	-9698
LATS2	-9601
WWTR1	-9598
CASP3	-9502
SAV1	-9277
MOB1A	-9188
YAP1	-8955
TJP1	-8832
STK3	-8208
MOB1B	-7938
YWHAE	-7771
TJP2	-7640
DVL2	-7613
YWHAB	-5335
WWC1	-5329
NPHP4	-3783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AMOTL2	-11160
AMOTL1	-10851
STK4	-10164
LATS1	-9809
AMOT	-9698
LATS2	-9601
WWTR1	-9598
CASP3	-9502
SAV1	-9277
MOB1A	-9188
YAP1	-8955
TJP1	-8832
STK3	-8208
MOB1B	-7938
YWHAE	-7771
TJP2	-7640
DVL2	-7613
YWHAB	-5335
WWC1	-5329
NPHP4	-3783

---

MET activates RAP1 and RAC1

MET activates RAP1 and RAC1

	664
set	MET activates RAP1 and RAC1
setSize	11
pANOVA	5.41e-06
s.dist	-0.792
p.adjustANOVA	2.27e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CRKL	-11034
CRK	-10952
GRB2	-10928
RAP1B	-10417
MET	-9674
RAC1	-8358
DOCK7	-8330
RAPGEF1	-7763
RAP1A	-7117
GAB1	-6967
HGF	-1883

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CRKL	-11034
CRK	-10952
GRB2	-10928
RAP1B	-10417
MET	-9674
RAC1	-8358
DOCK7	-8330
RAPGEF1	-7763
RAP1A	-7117
GAB1	-6967
HGF	-1883

---

MAPK3 (ERK1) activation

MAPK3 (ERK1) activation

	659
set	MAPK3 (ERK1) activation
setSize	10
pANOVA	2.78e-05
s.dist	-0.765
p.adjustANOVA	1e-04

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAP2K1	-11084
IL6ST	-10145
JAK1	-9989
IL6R	-9783
PTPN11	-9660
MAPK3	-8949
IL6	-6261
CDK1	-5951
JAK2	-4851
TYK2	-4701

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAP2K1	-11084
IL6ST	-10145
JAK1	-9989
IL6R	-9783
PTPN11	-9660
MAPK3	-8949
IL6	-6261
CDK1	-5951
JAK2	-4851
TYK2	-4701

---

RAF-independent MAPK1/3 activation

RAF-independent MAPK1/3 activation

	943
set	RAF-independent MAPK1/3 activation
setSize	23
pANOVA	2.16e-10
s.dist	-0.764
p.adjustANOVA	2.17e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP5	-11270
MAP2K1	-11084
MAPK1	-10995
DUSP16	-10981
DUSP7	-10486
DUSP6	-10231
IL6ST	-10145
JAK1	-9989
DUSP4	-9894
IL6R	-9783
PTPN11	-9660
MAPK3	-8949
DUSP1	-8928
DUSP9	-8393
PEA15	-8230
DUSP10	-6617
DUSP8	-6606
IL6	-6261
CDK1	-5951
JAK2	-4851

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP5	-11270
MAP2K1	-11084
MAPK1	-10995
DUSP16	-10981
DUSP7	-10486
DUSP6	-10231
IL6ST	-10145
JAK1	-9989
DUSP4	-9894
IL6R	-9783
PTPN11	-9660
MAPK3	-8949
DUSP1	-8928
DUSP9	-8393
PEA15	-8230
DUSP10	-6617
DUSP8	-6606
IL6	-6261
CDK1	-5951
JAK2	-4851
TYK2	-4701
MAP2K2	-1778
DUSP2	-1052

---

Interleukin-6 signaling

Interleukin-6 signaling

	609
set	Interleukin-6 signaling
setSize	11
pANOVA	1.18e-05
s.dist	-0.763
p.adjustANOVA	4.54e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CBL	-10473
IL6ST	-10145
JAK1	-9989
IL6R	-9783
PTPN11	-9660
STAT1	-9586
STAT3	-8517
IL6	-6261
SOCS3	-5184
JAK2	-4851
TYK2	-4701

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CBL	-10473
IL6ST	-10145
JAK1	-9989
IL6R	-9783
PTPN11	-9660
STAT1	-9586
STAT3	-8517
IL6	-6261
SOCS3	-5184
JAK2	-4851
TYK2	-4701

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	114
set	Beta-catenin phosphorylation cascade
setSize	17
pANOVA	5.52e-08
s.dist	-0.761
p.adjustANOVA	3.83e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
FRAT2	-6045
PPP2R1B	-4990
PPP2R5B	-4338
FRAT1	-595

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
APC	-8408
AXIN1	-8223
AMER1	-8065
PPP2R1A	-6397
PPP2R5C	-6296
FRAT2	-6045
PPP2R1B	-4990
PPP2R5B	-4338
FRAT1	-595

---

Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis

	725
set	Mitotic Telophase/Cytokinesis
setSize	13
pANOVA	2.05e-06
s.dist	-0.76
p.adjustANOVA	9.4e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WAPL	-10923
SMC1A	-10584
PLK1	-10443
RAD21	-10425
PDS5A	-10262
STAG2	-10205
PDS5B	-8616
NIPBL	-8564
SMC3	-7292
MAU2	-5931
STAG1	-5772
KIF23	-4475
KIF20A	-1447

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WAPL	-10923
SMC1A	-10584
PLK1	-10443
RAD21	-10425
PDS5A	-10262
STAG2	-10205
PDS5B	-8616
NIPBL	-8564
SMC3	-7292
MAU2	-5931
STAG1	-5772
KIF23	-4475
KIF20A	-1447

---

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

	78
set	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize	25
pANOVA	5.85e-11
s.dist	-0.756
p.adjustANOVA	6.52e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SEC24D	-11280
SEC23A	-11227
CANX	-11208
SEC24A	-11144
HLA-E	-11119
SEC13	-10720
SEC24B	-10646
PDIA3	-10410
TAP1	-10379
SEC24C	-10311
SEC31A	-9979
HSPA5	-9966
ERAP1	-9731
HLA-H	-9536
HLA-C	-9273
HLA-B	-8950
B2M	-7777
TAPBP	-7676
HLA-G	-7568
TAP2	-7516

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SEC24D	-11280
SEC23A	-11227
CANX	-11208
SEC24A	-11144
HLA-E	-11119
SEC13	-10720
SEC24B	-10646
PDIA3	-10410
TAP1	-10379
SEC24C	-10311
SEC31A	-9979
HSPA5	-9966
ERAP1	-9731
HLA-H	-9536
HLA-C	-9273
HLA-B	-8950
B2M	-7777
TAPBP	-7676
HLA-G	-7568
TAP2	-7516
CALR	-6927
SAR1B	-3725
HLA-F	-3567
HLA-A	-2888
ERAP2	13239

---

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

	273
set	Defective EXT1 causes exostoses 1, TRPS2 and CHDS
setSize	13
pANOVA	7.2e-06
s.dist	-0.719
p.adjustANOVA	2.92e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GPC6	-10762
SDC4	-10589
GPC4	-10309
GPC1	-9946
SDC2	-8067
EXT2	-8015
EXT1	-7609
AGRN	-7222
SDC1	-6782
SDC3	-6073
HSPG2	-5446
GPC5	-4208
GPC2	-2676

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GPC6	-10762
SDC4	-10589
GPC4	-10309
GPC1	-9946
SDC2	-8067
EXT2	-8015
EXT1	-7609
AGRN	-7222
SDC1	-6782
SDC3	-6073
HSPG2	-5446
GPC5	-4208
GPC2	-2676

---

Defective EXT2 causes exostoses 2

Defective EXT2 causes exostoses 2

	274
set	Defective EXT2 causes exostoses 2
setSize	13
pANOVA	7.2e-06
s.dist	-0.719
p.adjustANOVA	2.92e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GPC6	-10762
SDC4	-10589
GPC4	-10309
GPC1	-9946
SDC2	-8067
EXT2	-8015
EXT1	-7609
AGRN	-7222
SDC1	-6782
SDC3	-6073
HSPG2	-5446
GPC5	-4208
GPC2	-2676

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GPC6	-10762
SDC4	-10589
GPC4	-10309
GPC1	-9946
SDC2	-8067
EXT2	-8015
EXT1	-7609
AGRN	-7222
SDC1	-6782
SDC3	-6073
HSPG2	-5446
GPC5	-4208
GPC2	-2676

---

Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the early endosome membrane

	1283
set	Synthesis of PIPs at the early endosome membrane
setSize	16
pANOVA	1.38e-06
s.dist	-0.697
p.adjustANOVA	6.58e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTMR12	-11203
PIKFYVE	-9788
PIK3R4	-9423
VAC14	-9302
MTMR2	-9253
PI4K2A	-8161
PIK3C3	-8086
MTMR4	-8019
INPP5F	-7989
PIK3C2A	-7978
INPP4A	-7786
PI4K2B	-7232
MTM1	-6304
MTMR10	-5507
FIG4	-4129
INPP4B	4559

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTMR12	-11203
PIKFYVE	-9788
PIK3R4	-9423
VAC14	-9302
MTMR2	-9253
PI4K2A	-8161
PIK3C3	-8086
MTMR4	-8019
INPP5F	-7989
PIK3C2A	-7978
INPP4A	-7786
PI4K2B	-7232
MTM1	-6304
MTMR10	-5507
FIG4	-4129
INPP4B	4559

---

Signaling by PDGFRA extracellular domain mutants

Signaling by PDGFRA extracellular domain mutants

	1234
set	Signaling by PDGFRA extracellular domain mutants
setSize	12
pANOVA	3.55e-05
s.dist	-0.689
p.adjustANOVA	0.000124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	-11218
PIK3CB	-10967
GRB2	-10928
STAT1	-9586
PIK3R1	-9444
NRAS	-9293
PIK3CA	-8881
SOS1	-8846
STAT3	-8517
KRAS	-7194
PIK3R2	-5467
HRAS	14873

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	-11218
PIK3CB	-10967
GRB2	-10928
STAT1	-9586
PIK3R1	-9444
NRAS	-9293
PIK3CA	-8881
SOS1	-8846
STAT3	-8517
KRAS	-7194
PIK3R2	-5467
HRAS	14873

---

Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

	1235
set	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
setSize	12
pANOVA	3.55e-05
s.dist	-0.689
p.adjustANOVA	0.000124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	-11218
PIK3CB	-10967
GRB2	-10928
STAT1	-9586
PIK3R1	-9444
NRAS	-9293
PIK3CA	-8881
SOS1	-8846
STAT3	-8517
KRAS	-7194
PIK3R2	-5467
HRAS	14873

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	-11218
PIK3CB	-10967
GRB2	-10928
STAT1	-9586
PIK3R1	-9444
NRAS	-9293
PIK3CA	-8881
SOS1	-8846
STAT3	-8517
KRAS	-7194
PIK3R2	-5467
HRAS	14873

---

Activation of RAC1

Activation of RAC1

	48
set	Activation of RAC1
setSize	13
pANOVA	1.72e-05
s.dist	-0.688
p.adjustANOVA	6.43e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCK1	-11135
SLIT2	-10674
PAK1	-10640
PAK2	-10191
PAK4	-9314
NCK2	-8988
SOS1	-8846
RAC1	-8358
SOS2	-7183
ROBO1	-7141
PAK3	-4574
PAK5	-1369
PAK6	5967

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCK1	-11135
SLIT2	-10674
PAK1	-10640
PAK2	-10191
PAK4	-9314
NCK2	-8988
SOS1	-8846
RAC1	-8358
SOS2	-7183
ROBO1	-7141
PAK3	-4574
PAK5	-1369
PAK6	5967

---

Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the late endosome membrane

	1284
set	Synthesis of PIPs at the late endosome membrane
setSize	11
pANOVA	8.35e-05
s.dist	-0.685
p.adjustANOVA	0.000269

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIKFYVE	-9788
PIK3R4	-9423
VAC14	-9302
MTMR2	-9253
PIK3C3	-8086
MTMR4	-8019
PIK3C2A	-7978
MTMR9	-7864
MTM1	-6304
FIG4	-4129
MTMR7	2433

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIKFYVE	-9788
PIK3R4	-9423
VAC14	-9302
MTMR2	-9253
PIK3C3	-8086
MTMR4	-8019
PIK3C2A	-7978
MTMR9	-7864
MTM1	-6304
FIG4	-4129
MTMR7	2433

---

Signal transduction by L1

Signal transduction by L1

	1169
set	Signal transduction by L1
setSize	21
pANOVA	5.62e-08
s.dist	-0.684
p.adjustANOVA	3.86e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	-11255
ITGA5	-11230
ITGB1	-11155
MAP2K1	-11084
MAPK1	-10995
CSNK2A1	-10886
L1CAM	-10775
PAK1	-10640
EGFR	-10531
CSNK2A2	-10253
ITGAV	-10173
MAPK3	-8949
NRP1	-8764
RAC1	-8358
VAV2	-7167
ITGA9	-6351
FGFR1	-2958
NCAM1	-2110
MAP2K2	-1778
CSNK2B	7911

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	-11255
ITGA5	-11230
ITGB1	-11155
MAP2K1	-11084
MAPK1	-10995
CSNK2A1	-10886
L1CAM	-10775
PAK1	-10640
EGFR	-10531
CSNK2A2	-10253
ITGAV	-10173
MAPK3	-8949
NRP1	-8764
RAC1	-8358
VAV2	-7167
ITGA9	-6351
FGFR1	-2958
NCAM1	-2110
MAP2K2	-1778
CSNK2B	7911
ITGA2B	9389

---

ALK mutants bind TKIs

ALK mutants bind TKIs

	10
set	ALK mutants bind TKIs
setSize	12
pANOVA	4.26e-05
s.dist	-0.682
p.adjustANOVA	0.000146

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTC	-11168
EIF2AK3	-10957
FN1	-10893
PPM1B	-10633
STRN	-9764
PRKAR1A	-9591
ALK	-7854
HIP1	-7803
BIRC6	-7359
EML4	-3335
NPM1	-2560
BCL11A	7576

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTC	-11168
EIF2AK3	-10957
FN1	-10893
PPM1B	-10633
STRN	-9764
PRKAR1A	-9591
ALK	-7854
HIP1	-7803
BIRC6	-7359
EML4	-3335
NPM1	-2560
BCL11A	7576

---

FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes

	407
set	FOXO-mediated transcription of cell cycle genes
setSize	16
pANOVA	5.18e-06
s.dist	-0.658
p.adjustANOVA	2.18e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	-11243
FOXO3	-10755
SMAD4	-10603
CAV1	-10469
GADD45A	-10202
CDKN1B	-10176
SMAD2	-10052
BTG1	-9297
FOXO1	-9262
RBL2	-9205
CCNG2	-8156
SMAD3	-7704
KLF4	-6673
FOXO4	-5667
MSTN	8126
PCBP4	14098

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	-11243
FOXO3	-10755
SMAD4	-10603
CAV1	-10469
GADD45A	-10202
CDKN1B	-10176
SMAD2	-10052
BTG1	-9297
FOXO1	-9262
RBL2	-9205
CCNG2	-8156
SMAD3	-7704
KLF4	-6673
FOXO4	-5667
MSTN	8126
PCBP4	14098

---

Syndecan interactions

Syndecan interactions

	1273
set	Syndecan interactions
setSize	20
pANOVA	5.15e-07
s.dist	-0.648
p.adjustANOVA	2.7e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	-11255
ITGA6	-11210
ITGB1	-11155
ACTN1	-11138
ITGA2	-10877
TNC	-10814
SDC4	-10589
ITGAV	-10173
TGFB1	-9334
TRAPPC4	-8603
SDC2	-8067
ITGB5	-8045
CASK	-7112
SDC1	-6782
SDC3	-6073
PRKCA	-5486
FGF2	-5236
THBS1	6048
VTN	6412
ITGB4	8038

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	-11255
ITGA6	-11210
ITGB1	-11155
ACTN1	-11138
ITGA2	-10877
TNC	-10814
SDC4	-10589
ITGAV	-10173
TGFB1	-9334
TRAPPC4	-8603
SDC2	-8067
ITGB5	-8045
CASK	-7112
SDC1	-6782
SDC3	-6073
PRKCA	-5486
FGF2	-5236
THBS1	6048
VTN	6412
ITGB4	8038

---

Prolonged ERK activation events

Prolonged ERK activation events

	922
set	Prolonged ERK activation events
setSize	14
pANOVA	2.87e-05
s.dist	-0.646
p.adjustANOVA	0.000103

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAP2K1	-11084
CRKL	-11034
MAPK1	-10995
CRK	-10952
FRS2	-9097
MAPK3	-8949
BRAF	-7961
RAPGEF1	-7763
RAP1A	-7117
YWHAB	-5335
KIDINS220	-4716
NTRK1	-3485
MAP2K2	-1778
NGF	8729

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAP2K1	-11084
CRKL	-11034
MAPK1	-10995
CRK	-10952
FRS2	-9097
MAPK3	-8949
BRAF	-7961
RAPGEF1	-7763
RAP1A	-7117
YWHAB	-5335
KIDINS220	-4716
NTRK1	-3485
MAP2K2	-1778
NGF	8729

---

CTLA4 inhibitory signaling

CTLA4 inhibitory signaling

	147
set	CTLA4 inhibitory signaling
setSize	17
pANOVA	4.47e-06
s.dist	-0.643
p.adjustANOVA	1.92e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
YES1	-10514
AKT3	-10477
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
PTPN11	-9660
SRC	-7851
FYN	-7099
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338
AKT1	-2579
LYN	-2496
AKT2	14457

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
YES1	-10514
AKT3	-10477
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
PTPN11	-9660
SRC	-7851
FYN	-7099
PPP2R1A	-6397
PPP2R5C	-6296
PPP2R1B	-4990
PPP2R5B	-4338
AKT1	-2579
LYN	-2496
AKT2	14457

---

Gastrin-CREB signalling pathway via PKC and MAPK

Gastrin-CREB signalling pathway via PKC and MAPK

	479
set	Gastrin-CREB signalling pathway via PKC and MAPK
setSize	17
pANOVA	4.75e-06
s.dist	-0.641
p.adjustANOVA	2.02e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HBEGF	-11003
MAPK1	-10995
GRB2	-10928
EGFR	-10531
RPS6KA3	-10363
NRAS	-9293
MAPK3	-8949
SOS1	-8846
CREB1	-8171
KRAS	-7194
RPS6KA2	-6326
RPS6KA1	-6227
MMP3	-5706
PRKCA	-5486
MAPK7	-3522
CCKBR	-1384
HRAS	14873

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HBEGF	-11003
MAPK1	-10995
GRB2	-10928
EGFR	-10531
RPS6KA3	-10363
NRAS	-9293
MAPK3	-8949
SOS1	-8846
CREB1	-8171
KRAS	-7194
RPS6KA2	-6326
RPS6KA1	-6227
MMP3	-5706
PRKCA	-5486
MAPK7	-3522
CCKBR	-1384
HRAS	14873

---

Cell-extracellular matrix interactions

Cell-extracellular matrix interactions

	175
set	Cell-extracellular matrix interactions
setSize	16
pANOVA	9.64e-06
s.dist	-0.639
p.adjustANOVA	3.82e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FLNC	-11249
FLNA	-11232
ITGB1	-11155
ACTN1	-11138
FERMT2	-11109
LIMS1	-9445
PARVB	-8827
PXN	-7403
VASP	-7162
ILK	-6739
RSU1	-6419
PARVA	-6330
ARHGEF6	-3564
LIMS2	-1547
FBLIM1	-682
TESK1	10849

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FLNC	-11249
FLNA	-11232
ITGB1	-11155
ACTN1	-11138
FERMT2	-11109
LIMS1	-9445
PARVB	-8827
PXN	-7403
VASP	-7162
ILK	-6739
RSU1	-6419
PARVA	-6330
ARHGEF6	-3564
LIMS2	-1547
FBLIM1	-682
TESK1	10849

---

Regulation of gene expression by Hypoxia-inducible Factor

Regulation of gene expression by Hypoxia-inducible Factor

	1068
set	Regulation of gene expression by Hypoxia-inducible Factor
setSize	11
pANOVA	0.000244
s.dist	-0.639
p.adjustANOVA	0.000714

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EPAS1	-11157
HIF1A	-11032
CITED2	-10905
ARNT	-10656
CREBBP	-9655
EP300	-9548
CA9	-9179
HIGD1A	-6950
VEGFA	1235
HIF3A	1620
EPO	5297

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EPAS1	-11157
HIF1A	-11032
CITED2	-10905
ARNT	-10656
CREBBP	-9655
EP300	-9548
CA9	-9179
HIGD1A	-6950
VEGFA	1235
HIF3A	1620
EPO	5297

---

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Regulation of cholesterol biosynthesis by SREBP (SREBF)

	1065
set	Regulation of cholesterol biosynthesis by SREBP (SREBF)
setSize	55
pANOVA	3.95e-16
s.dist	-0.634
p.adjustANOVA	9.46e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SEC24D	-11280
INSIG1	-11275
HMGCR	-11253
SQLE	-11242
SEC23A	-11227
HMGCS1	-11180
CYP51A1	-11166
SEC24A	-11144
IDI1	-11106
SREBF2	-11089
MED1	-11049
FDFT1	-11018
HELZ2	-10991
SC5D	-10873
DHCR7	-10855
PPARA	-10816
NFYA	-10704
SEC24B	-10646
SEC24C	-10311
NCOA2	-10279

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SEC24D	-11280
INSIG1	-11275
HMGCR	-11253
SQLE	-11242
SEC23A	-11227
HMGCS1	-11180
CYP51A1	-11166
SEC24A	-11144
IDI1	-11106
SREBF2	-11089
MED1	-11049
FDFT1	-11018
HELZ2	-10991
SC5D	-10873
DHCR7	-10855
PPARA	-10816
NFYA	-10704
SEC24B	-10646
SEC24C	-10311
NCOA2	-10279
SCD	-10199
MTF1	-10117
SP1	-9960
KPNB1	-9790
CREBBP	-9655
FASN	-9635
MBTPS2	-9157
TBL1XR1	-8937
TGS1	-8714
MVD	-8259
INSIG2	-7996
TBL1X	-7506
GPAM	-7211
NCOA6	-6993
RAN	-6907
ACACA	-6705
CHD9	-6687
NCOA1	-6430
MBTPS1	-6159
RXRA	-6096
CARM1	-6020
FDPS	-5771
LSS	-5697
GGPS1	-5677
MVK	-5111
SCAP	-4798
SAR1B	-3725
NFYB	-1906
PMVK	64
ELOVL6	1965
ACACB	11796
NFYC	12639
TM7SF2	14698
SMARCD3	14895
SREBF1	14902

---

Signaling by WNT in cancer

Signaling by WNT in cancer

	1250
set	Signaling by WNT in cancer
setSize	32
pANOVA	5.49e-10
s.dist	-0.633
p.adjustANOVA	5.19e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
LRP6	-10666
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
TNKS	-10471
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
FZD5	-9793
TNKS2	-9338
KREMEN1	-9123
APC	-8408
AXIN1	-8223
FZD8	-8140
AMER1	-8065
CTBP2	-7543
FZD6	-7097
PPP2R1A	-6397

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
PPP2CB	-10791
LRP6	-10666
GSK3B	-10632
CTNNB1	-10568
CSNK1A1	-10561
TNKS	-10471
PPP2R5A	-10349
PPP2R5E	-10222
PPP2CA	-9827
FZD5	-9793
TNKS2	-9338
KREMEN1	-9123
APC	-8408
AXIN1	-8223
FZD8	-8140
AMER1	-8065
CTBP2	-7543
FZD6	-7097
PPP2R1A	-6397
PPP2R5C	-6296
PORCN	-6161
KREMEN2	-6104
FZD4	-6015
DKK2	-5215
PPP2R1B	-4990
PPP2R5B	-4338
LRP5	-3923
DKK1	-3745
RNF43	5449
TCF7L2	11251
CTBP1	13492

---

Processing and activation of SUMO

Processing and activation of SUMO

	912
set	Processing and activation of SUMO
setSize	10
pANOVA	0.000534
s.dist	-0.632
p.adjustANOVA	0.00143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA2	-10392
SENP2	-10330
SENP1	-9567
SUMO3	-9159
SENP5	-8296
SAE1	-7953
SUMO2	-7239
UBE2I	-5331
SUMO1	-4980
RWDD3	9620

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA2	-10392
SENP2	-10330
SENP1	-9567
SUMO3	-9159
SENP5	-8296
SAE1	-7953
SUMO2	-7239
UBE2I	-5331
SUMO1	-4980
RWDD3	9620

---

ERK/MAPK targets

ERK/MAPK targets

	359
set	ERK/MAPK targets
setSize	22
pANOVA	2.85e-07
s.dist	-0.632
p.adjustANOVA	1.59e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-11026
MAPK1	-10995
PPP2CB	-10791
DUSP7	-10486
RPS6KA3	-10363
DUSP6	-10231
DUSP4	-9894
PPP2CA	-9827
MAPK14	-9054
MAPK3	-8949
VRK3	-8340
ELK1	-8163
DUSP3	-8063
RPS6KA5	-6900
PPP2R1A	-6397
RPS6KA2	-6326
RPS6KA1	-6227
PPP2R1B	-4990
MAPK7	-3522
MEF2C	2785

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-11026
MAPK1	-10995
PPP2CB	-10791
DUSP7	-10486
RPS6KA3	-10363
DUSP6	-10231
DUSP4	-9894
PPP2CA	-9827
MAPK14	-9054
MAPK3	-8949
VRK3	-8340
ELK1	-8163
DUSP3	-8063
RPS6KA5	-6900
PPP2R1A	-6397
RPS6KA2	-6326
RPS6KA1	-6227
PPP2R1B	-4990
MAPK7	-3522
MEF2C	2785
MEF2A	5395
MAPK11	12572

---

Frs2-mediated activation

Frs2-mediated activation

	439
set	Frs2-mediated activation
setSize	12
pANOVA	0.00016
s.dist	-0.629
p.adjustANOVA	0.000486

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAP2K1	-11084
CRKL	-11034
MAPK1	-10995
FRS2	-9097
MAPK3	-8949
BRAF	-7961
RAPGEF1	-7763
RAP1A	-7117
YWHAB	-5335
NTRK1	-3485
MAP2K2	-1778
NGF	8729

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAP2K1	-11084
CRKL	-11034
MAPK1	-10995
FRS2	-9097
MAPK3	-8949
BRAF	-7961
RAPGEF1	-7763
RAP1A	-7117
YWHAB	-5335
NTRK1	-3485
MAP2K2	-1778
NGF	8729

---

STAT5 activation downstream of FLT3 ITD mutants

STAT5 activation downstream of FLT3 ITD mutants

	1132
set	STAT5 activation downstream of FLT3 ITD mutants
setSize	10
pANOVA	0.000578
s.dist	-0.628
p.adjustANOVA	0.00153

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	-11243
GRB2	-10928
PTPN11	-9660
GAB2	-9072
PIM1	-8519
BCL2L1	-7142
STAT5B	-4295
STAT5A	-3099
NOX4	-1405
FLT3	2252

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	-11243
GRB2	-10928
PTPN11	-9660
GAB2	-9072
PIM1	-8519
BCL2L1	-7142
STAT5B	-4295
STAT5A	-3099
NOX4	-1405
FLT3	2252

---

Signaling by PDGFR in disease

Signaling by PDGFR in disease

	1233
set	Signaling by PDGFR in disease
setSize	20
pANOVA	1.17e-06
s.dist	-0.628
p.adjustANOVA	5.65e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDGFRA	-11218
PIK3CB	-10967
GRB2	-10928
GOLGA4	-10758
STRN	-9764
FIP1L1	-9616
STAT1	-9586
PIK3R1	-9444
NRAS	-9293
PIK3CA	-8881
SOS1	-8846
STAT3	-8517
KRAS	-7194
WDR48	-5606
PIK3R2	-5467
KANK1	-5112
KDR	-4501
ETV6	2077
BIN2	2795
HRAS	14873

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDGFRA	-11218
PIK3CB	-10967
GRB2	-10928
GOLGA4	-10758
STRN	-9764
FIP1L1	-9616
STAT1	-9586
PIK3R1	-9444
NRAS	-9293
PIK3CA	-8881
SOS1	-8846
STAT3	-8517
KRAS	-7194
WDR48	-5606
PIK3R2	-5467
KANK1	-5112
KDR	-4501
ETV6	2077
BIN2	2795
HRAS	14873

---

Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)

	197
set	Citric acid cycle (TCA cycle)
setSize	22
pANOVA	3.63e-07
s.dist	-0.626
p.adjustANOVA	1.96e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDH2	-11079
ME2	-10846
CS	-10604
SDHA	-10529
SUCLG2	-10244
MDH2	-9964
OGDH	-9550
DLD	-9398
DLST	-9257
SUCLA2	-8074
SDHB	-7529
NNT	-7468
SDHC	-7321
SDHD	-7213
IDH3A	-6427
IDH3B	-5545
FH	-4807
SUCLG1	-3607
IDH3G	-1805
ME3	504

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDH2	-11079
ME2	-10846
CS	-10604
SDHA	-10529
SUCLG2	-10244
MDH2	-9964
OGDH	-9550
DLD	-9398
DLST	-9257
SUCLA2	-8074
SDHB	-7529
NNT	-7468
SDHC	-7321
SDHD	-7213
IDH3A	-6427
IDH3B	-5545
FH	-4807
SUCLG1	-3607
IDH3G	-1805
ME3	504
FAHD1	5378
ACO2	7258

---

Signaling by Activin

Signaling by Activin

	1176
set	Signaling by Activin
setSize	15
pANOVA	2.67e-05
s.dist	-0.626
p.adjustANOVA	9.65e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	-10995
SMAD4	-10603
INHBA	-10467
SMAD2	-10052
ACVR2B	-9533
MAPK3	-8949
SMAD3	-7704
FST	-6486
ACVR1B	-5927
ACVR1C	-5440
FSTL3	-5320
INHBB	-4752
ACVR2A	-4320
DRAP1	-4214
FOXH1	10577

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	-10995
SMAD4	-10603
INHBA	-10467
SMAD2	-10052
ACVR2B	-9533
MAPK3	-8949
SMAD3	-7704
FST	-6486
ACVR1B	-5927
ACVR1C	-5440
FSTL3	-5320
INHBB	-4752
ACVR2A	-4320
DRAP1	-4214
FOXH1	10577

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.9          
##  [49] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       rlang_1.0.2           
##  [55] later_1.3.0            AnnotationDbi_1.54.1   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.0            cachem_1.0.6          
##  [61] cli_3.2.0              generics_0.1.2         RSQLite_2.2.10        
##  [64] broom_0.7.12           evaluate_0.15          fastmap_1.1.0         
##  [67] yaml_2.3.5             knitr_1.37             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.32.0       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.0        
##  [76] rstudioapi_0.13        png_0.1-7              reprex_2.0.1          
##  [79] geneplotter_1.70.0     bslib_0.3.1            stringi_1.7.6         
##  [82] highr_0.9              desc_1.4.1             lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.3.8            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] assertthat_0.2.1       rprojroot_2.0.2        withr_2.5.0           
## [100] GenomeInfoDbData_1.2.6 hms_1.1.1              grid_4.2.0            
## [103] rmarkdown_2.13         shiny_1.7.1            lubridate_1.8.0

END of report