date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA -0.4520464
## 7SK       -2.2982399
## A1BG      -3.3008939
## A1BG-AS1   0.3211569
## A1CF      -0.7352419
## A2M       30.2687300
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 24
num_genes_in_profile 25203
duplicated_genes_present 0
num_profile_genes_in_sets 2719
num_profile_genes_not_in_sets 22484

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:
Gene sets metrics
Gene sets metrics
num_genesets 24
num_genesets_excluded 0
num_genesets_included 24

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 24 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Receptor Mediated Mitophagy 11 8.03e-06 -0.7770 2.86e-05
Mucopolysaccharidoses 11 1.17e-05 0.7630 3.52e-05
Mitophagy 28 1.15e-06 -0.5310 6.88e-06
Nucleotide biosynthesis 12 3.87e-03 -0.4820 5.92e-03
Mitochondrial iron-sulfur cluster biogenesis 13 6.85e-03 -0.4330 8.65e-03
Reduction of cytosolic Ca++ levels 12 9.90e-03 0.4300 1.13e-02
Stabilization of p53 53 1.02e-07 -0.4220 8.19e-07
Diseases of carbohydrate metabolism 30 2.13e-03 0.3240 3.66e-03
Cellular response to starvation 150 1.48e-11 -0.3190 3.55e-10
PTEN Regulation 140 1.06e-08 -0.2800 1.27e-07
Resolution of D-Loop Structures 33 1.41e-02 0.2470 1.54e-02
Gene Silencing by RNA 97 4.04e-05 -0.2410 9.79e-05
Pyruvate metabolism and Citric Acid (TCA) cycle 52 3.95e-03 -0.2310 5.92e-03
Signaling by the B Cell Receptor (BCR) 106 4.08e-05 -0.2310 9.79e-05
Mitochondrial biogenesis 91 3.04e-04 -0.2190 6.62e-04
Mitochondrial protein import 64 5.96e-03 -0.1990 8.42e-03
Oxidative Stress Induced Senescence 82 9.27e-03 -0.1660 1.11e-02
Respiratory electron transport 103 6.51e-03 -0.1550 8.65e-03
Phospholipid metabolism 186 7.66e-04 -0.1430 1.41e-03
Mitochondrial translation 96 1.58e-02 -0.1420 1.65e-02
Metabolism of amino acids and derivatives 339 8.34e-06 -0.1410 2.86e-05
Nervous system development 526 2.94e-06 -0.1190 1.41e-05
Complex I biogenesis 57 1.25e-01 -0.1170 1.25e-01
Metabolism 1871 5.95e-04 -0.0476 1.19e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Receptor Mediated Mitophagy 11 8.03e-06 -0.7770 2.86e-05
Mucopolysaccharidoses 11 1.17e-05 0.7630 3.52e-05
Mitophagy 28 1.15e-06 -0.5310 6.88e-06
Nucleotide biosynthesis 12 3.87e-03 -0.4820 5.92e-03
Mitochondrial iron-sulfur cluster biogenesis 13 6.85e-03 -0.4330 8.65e-03
Reduction of cytosolic Ca++ levels 12 9.90e-03 0.4300 1.13e-02
Stabilization of p53 53 1.02e-07 -0.4220 8.19e-07
Diseases of carbohydrate metabolism 30 2.13e-03 0.3240 3.66e-03
Cellular response to starvation 150 1.48e-11 -0.3190 3.55e-10
PTEN Regulation 140 1.06e-08 -0.2800 1.27e-07
Resolution of D-Loop Structures 33 1.41e-02 0.2470 1.54e-02
Gene Silencing by RNA 97 4.04e-05 -0.2410 9.79e-05
Pyruvate metabolism and Citric Acid (TCA) cycle 52 3.95e-03 -0.2310 5.92e-03
Signaling by the B Cell Receptor (BCR) 106 4.08e-05 -0.2310 9.79e-05
Mitochondrial biogenesis 91 3.04e-04 -0.2190 6.62e-04
Mitochondrial protein import 64 5.96e-03 -0.1990 8.42e-03
Oxidative Stress Induced Senescence 82 9.27e-03 -0.1660 1.11e-02
Respiratory electron transport 103 6.51e-03 -0.1550 8.65e-03
Phospholipid metabolism 186 7.66e-04 -0.1430 1.41e-03
Mitochondrial translation 96 1.58e-02 -0.1420 1.65e-02
Metabolism of amino acids and derivatives 339 8.34e-06 -0.1410 2.86e-05
Nervous system development 526 2.94e-06 -0.1190 1.41e-05
Complex I biogenesis 57 1.25e-01 -0.1170 1.25e-01
Metabolism 1871 5.95e-04 -0.0476 1.19e-03


Detailed Gene set reports



Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
19
set Receptor Mediated Mitophagy
setSize 11
pANOVA 8.03e-06
s.dist -0.777
p.adjustANOVA 2.86e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC -12015
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
CSNK2A2 -10568
MAP1LC3B -10436
MAP1LC3A -10048
CSNK2B -9864
ATG5 -8156
ATG12 -4960
FUNDC1 -3325

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC -12015
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
CSNK2A2 -10568
MAP1LC3B -10436
MAP1LC3A -10048
CSNK2B -9864
ATG5 -8156
ATG12 -4960
FUNDC1 -3325


Mucopolysaccharidoses

Mucopolysaccharidoses
12
set Mucopolysaccharidoses
setSize 11
pANOVA 1.17e-05
s.dist 0.763
p.adjustANOVA 3.52e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NAGLU 12266
ARSB 12189
GALNS 11854
IDUA 11641
SGSH 11569
GNS 11202
GLB1 10265
GUSB 9533
IDS 8281
HGSNAT 6544
HYAL1 4893

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NAGLU 12266
ARSB 12189
GALNS 11854
IDUA 11641
SGSH 11569
GNS 11202
GLB1 10265
GUSB 9533
IDS 8281
HGSNAT 6544
HYAL1 4893


Mitophagy

Mitophagy
11
set Mitophagy
setSize 28
pANOVA 1.15e-06
s.dist -0.531
p.adjustANOVA 6.88e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC -12015
TOMM5 -11478
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
UBC -11024
TOMM22 -10580
CSNK2A2 -10568
MAP1LC3B -10436
PINK1 -10350
SQSTM1 -10076
MAP1LC3A -10048
CSNK2B -9864
TOMM6 -9737
MFN2 -9248
ATG5 -8156
UBA52 -7355
MTERF3 -7267
UBB -6063
TOMM40 -5710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC -12015
TOMM5 -11478
PGAM5 -11444
CSNK2A1 -11231
ULK1 -11121
UBC -11024
TOMM22 -10580
CSNK2A2 -10568
MAP1LC3B -10436
PINK1 -10350
SQSTM1 -10076
MAP1LC3A -10048
CSNK2B -9864
TOMM6 -9737
MFN2 -9248
ATG5 -8156
UBA52 -7355
MTERF3 -7267
UBB -6063
TOMM40 -5710
ATG12 -4960
FUNDC1 -3325
TOMM20 -2687
TOMM7 1305
TOMM70 2169
RPS27A 5458
MFN1 9758
VDAC1 10424


Nucleotide biosynthesis

Nucleotide biosynthesis
14
set Nucleotide biosynthesis
setSize 12
pANOVA 0.00387
s.dist -0.482
p.adjustANOVA 0.00592



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATIC -11566
GART -11514
PPAT -10725
IMPDH2 -9672
PAICS -9504
IMPDH1 -9283
CAD -8582
ADSL -7668
GMPS -4747
UMPS -2534
DHODH 7463
PFAS 10473

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATIC -11566
GART -11514
PPAT -10725
IMPDH2 -9672
PAICS -9504
IMPDH1 -9283
CAD -8582
ADSL -7668
GMPS -4747
UMPS -2534
DHODH 7463
PFAS 10473


Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis
8
set Mitochondrial iron-sulfur cluster biogenesis
setSize 13
pANOVA 0.00685
s.dist -0.433
p.adjustANOVA 0.00865



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSCB -11093
SLC25A37 -10487
GLRX5 -10136
FDX1 -9232
NFS1 -9194
ISCA1 -8179
ISCU -6816
FDX2 -6143
LYRM4 -3723
SLC25A28 -2863
ISCA2 2319
FXN 3074
FDXR 6900

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSCB -11093
SLC25A37 -10487
GLRX5 -10136
FDX1 -9232
NFS1 -9194
ISCA1 -8179
ISCU -6816
FDX2 -6143
LYRM4 -3723
SLC25A28 -2863
ISCA2 2319
FXN 3074
FDXR 6900


Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels
20
set Reduction of cytosolic Ca++ levels
setSize 12
pANOVA 0.0099
s.dist 0.43
p.adjustANOVA 0.0113



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC8A3 12132
ATP2A3 12114
CALM1 11432
SLC8A2 11234
SLC8A1 10204
ATP2B4 8032
ATP2A2 7639
ATP2B1 7055
ATP2B3 5389
ATP2B2 1401
ATP2A1 -7639
SRI -9072

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC8A3 12132
ATP2A3 12114
CALM1 11432
SLC8A2 11234
SLC8A1 10204
ATP2B4 8032
ATP2A2 7639
ATP2B1 7055
ATP2B3 5389
ATP2B2 1401
ATP2A1 -7639
SRI -9072


Stabilization of p53

Stabilization of p53
24
set Stabilization of p53
setSize 53
pANOVA 1.02e-07
s.dist -0.422
p.adjustANOVA 8.19e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHEK2 -11506
PSMD14 -11242
PSME4 -11208
UBC -11024
PSMA7 -10789
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PSMB7 -9263
PSME1 -9261
PSMD3 -8656
PSMD9 -8231
PSMD6 -8169
PSMF1 -8140

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHEK2 -11506
PSMD14 -11242
PSME4 -11208
UBC -11024
PSMA7 -10789
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PSMB7 -9263
PSME1 -9261
PSMD3 -8656
PSMD9 -8231
PSMD6 -8169
PSMF1 -8140
PSMC4 -7727
PSMC6 -7633
PSMB5 -7489
PSMD10 -7419
UBA52 -7355
PSMD2 -7349
PHF20 -7277
PSMB6 -7067
PSMD7 -6706
PSMB1 -6644
PSMA3 -6131
UBB -6063
PSMD13 -5738
PSME2 -4577
PSMA2 -4323
PSMC1 -3828
TP53 -3707
MDM2 -3649
PSMB2 -3623
PSMA6 -3583
PSMB4 -1449
PSMC3 -1344
ATM -315
PSMD4 774
PSMD12 846
MDM4 3290
RPS27A 5458
PSMA5 5639
PSMC5 7127
PSMD11 7823
PSMB3 8008
PSMB10 9640
PSME3 11914


Diseases of carbohydrate metabolism

Diseases of carbohydrate metabolism
3
set Diseases of carbohydrate metabolism
setSize 30
pANOVA 0.00213
s.dist 0.324
p.adjustANOVA 0.00366



Top enriched genes

Top 20 genes
GeneID Gene Rank
GBE1 12893
GAA 12643
NAGLU 12266
ARSB 12189
GALNS 11854
IDUA 11641
SGSH 11569
G6PC3 11373
GNS 11202
GYG1 10732
PPP1R3C 10676
GLB1 10265
GYG2 10220
GUSB 9533
NHLRC1 9313
IDS 8281
KHK 6584
HGSNAT 6544
RPS27A 5458
HYAL1 4893

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GBE1 12893
GAA 12643
NAGLU 12266
ARSB 12189
GALNS 11854
IDUA 11641
SGSH 11569
G6PC3 11373
GNS 11202
GYG1 10732
PPP1R3C 10676
GLB1 10265
GYG2 10220
GUSB 9533
NHLRC1 9313
IDS 8281
KHK 6584
HGSNAT 6544
RPS27A 5458
HYAL1 4893
ALDOB 2831
RPIA -1922
UBB -6063
DCXR -6892
UBA52 -7355
SLC37A4 -7515
EPM2A -7722
GYS1 -9320
TALDO1 -10514
UBC -11024


Cellular response to starvation

Cellular response to starvation
1
set Cellular response to starvation
setSize 150
pANOVA 1.48e-11
s.dist -0.319
p.adjustANOVA 3.55e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
FLCN -11793
ATP6V1B2 -11711
SH3BP4 -11544
ASNS -11505
RRAGC -11414
EIF2S2 -11280
RPS17 -11161
NPRL3 -11155
RPL22L1 -11075
WDR24 -10956
MLST8 -10940
FNIP1 -10893
RPS2 -10847
EIF2S3 -10799
CEBPG -10559
RPL10A -10326
SEC13 -10319
RPL9 -10276
ATP6V1F -10238
TCIRG1 -10180

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FLCN -11793
ATP6V1B2 -11711
SH3BP4 -11544
ASNS -11505
RRAGC -11414
EIF2S2 -11280
RPS17 -11161
NPRL3 -11155
RPL22L1 -11075
WDR24 -10956
MLST8 -10940
FNIP1 -10893
RPS2 -10847
EIF2S3 -10799
CEBPG -10559
RPL10A -10326
SEC13 -10319
RPL9 -10276
ATP6V1F -10238
TCIRG1 -10180
ATP6V0D2 -10159
MIOS -10085
RPS13 -10067
DDIT3 -10011
RPL26L1 -10003
RPS25 -9987
RPL34 -9972
RPL37A -9962
SEH1L -9948
RPL12 -9944
RPS6 -9840
RPS3A -9784
RPS18 -9734
RPL17 -9599
ATP6V1E1 -9595
EIF2S1 -9559
ATF2 -9551
RPL36 -9425
RPS9 -9422
RPL26 -9404
RPL31 -9388
RPS15A -9361
FAU -9217
RPS4X -9149
RPL11 -9136
ATP6V0E1 -9046
RPS10 -8990
ATP6V0C -8842
RPLP2 -8827
RPL36AL -8817
ATP6V0B -8790
BMT2 -8710
LAMTOR4 -8664
RPL35 -8625
RPS12 -8467
RPL27A -8412
RPS3 -8350
RPS11 -8319
RPS19 -8226
RPL8 -8164
RPS15 -8015
CEBPB -7684
RPL18A -7530
RPL6 -7455
RPL13A -7403
RPL3 -7375
UBA52 -7355
ATF4 -7315
RPL18 -7207
RPL39L -7141
SESN2 -7091
RPL14 -6909
RPL21 -6840
RPS5 -6800
RPL39 -6675
RPL7A -6670
WDR59 -6585
ATP6V1G1 -6445
RPS8 -6290
RPL28 -6287
LAMTOR1 -6134
RPL22 -6014
RRAGD -5673
NPRL2 -5546
RPL32 -5445
RPS20 -5374
RPL37 -5004
RPL41 -4994
RPL24 -4966
RPL29 -4883
RPL36A -4846
ATF3 -4410
RPL30 -4218
RPS16 -4149
RPL10 -4126
RPL13 -3746
RPL7 -3582
TRIB3 -3462
RRAGB -3264
RPS21 -3225
RPS26 -2804
LAMTOR3 -2775
IMPACT -1842
RPLP0 -1594
RPL35A -1535
RPS14 -1250
RPL15 -826
RPS29 -684
RPL3L -537
DEPDC5 -60
RPSA 306
RPS27 679
RPL38 1610
RPS24 2437
ATP6V1D 2511
RPS28 2787
ATP6V1C2 3750
RPL19 4011
RPL5 4778
FNIP2 5005
RPS7 5242
RPS27A 5458
LAMTOR2 5521
RPL23 5870
LAMTOR5 6347
RPL27 6838
RPS23 7043
RPS27L 7433
SESN1 7831
KPTN 8198
ATP6V1C1 8376
ATP6V1B1 8385
ATP6V1H 8462
ATP6V1G2 8543
MTOR 9066
RPLP1 9129
ATP6V1E2 9364
ITFG2 9774
ATP6V1A 9905
RPTOR 10704
GCN1 10768
SLC38A9 10806
EIF2AK4 10968
RPL4 11454
RPL23A 11464
SZT2 11672
RRAGA 11673
RHEB 11794
ATP6V0D1 11904
ATP6V0E2 12932


PTEN Regulation

PTEN Regulation
16
set PTEN Regulation
setSize 140
pANOVA 1.06e-08
s.dist -0.28
p.adjustANOVA 1.27e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
EGR1 -12039
USP7 -11933
GATAD2A -11675
TNKS -11632
AGO2 -11451
RRAGC -11414
OTUD3 -11407
TNRC6B -11300
PSMD14 -11242
SUZ12 -11232
CSNK2A1 -11231
PSME4 -11208
UBC -11024
RCOR1 -10993
MLST8 -10940
PSMA7 -10789
VAPA -10722
STUB1 -10672
KDM1A -10653
REST -10650

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EGR1 -12039
USP7 -11933
GATAD2A -11675
TNKS -11632
AGO2 -11451
RRAGC -11414
OTUD3 -11407
TNRC6B -11300
PSMD14 -11242
SUZ12 -11232
CSNK2A1 -11231
PSME4 -11208
UBC -11024
RCOR1 -10993
MLST8 -10940
PSMA7 -10789
VAPA -10722
STUB1 -10672
KDM1A -10653
REST -10650
SEM1 -10597
CSNK2A2 -10568
AGO3 -10535
PSMA4 -10526
PSMB9 -10429
HDAC2 -10405
PSMB8 -10402
MAPK3 -10361
PSMA1 -10263
PSMD5 -10259
HDAC5 -10164
GATAD2B -9926
CSNK2B -9864
PSMD1 -9807
PSMC2 -9799
MAPK1 -9787
PSMD8 -9715
ATF2 -9551
MTA2 -9276
PSMB7 -9263
PSME1 -9261
CNOT6L -8963
TRIM27 -8933
EED -8808
LAMTOR4 -8664
PSMD3 -8656
AGO1 -8274
MAF1 -8271
PSMD9 -8231
PSMD6 -8169
PSMF1 -8140
PHC3 -8002
PSMC4 -7727
PTENP1 -7709
PSMC6 -7633
RBBP7 -7607
RNF2 -7600
PSMB5 -7489
PTEN -7485
PSMD10 -7419
UBA52 -7355
PSMD2 -7349
MBD3 -7259
PSMB6 -7067
SNAI2 -6981
BMI1 -6886
PSMD7 -6706
PSMB1 -6644
CBX6 -6492
XIAP -6377
MTA1 -6145
LAMTOR1 -6134
PSMA3 -6131
UBB -6063
HDAC1 -6062
RBBP4 -6029
PML -5812
PSMD13 -5738
CHD3 -5721
RRAGD -5673
ATN1 -5555
TNRC6C -5453
CHD4 -4878
PSME2 -4577
PSMA2 -4323
PSMC1 -3828
TP53 -3707
PSMB2 -3623
PSMA6 -3583
RRAGB -3264
RING1 -3256
LAMTOR3 -2775
SALL4 -2142
AKT1 -1843
PSMB4 -1449
PSMC3 -1344
SNAI1 -548
NR2E1 -509
MTA3 682
PSMD4 774
PSMD12 846
RNF146 2351
TNRC6A 2975
USP13 4776
CBX4 5340
RPS27A 5458
LAMTOR2 5521
PSMA5 5639
TNKS2 6189
FRK 6316
LAMTOR5 6347
AKT3 6728
MOV10 6768
PSMC5 7127
HDAC7 7134
PSMD11 7823
SCMH1 7914
PSMB3 8008
CBX2 8254
CBX8 8411
AGO4 8669
PHC1 8872
MTOR 9066
PSMB10 9640
AKT2 9835
PREX2 10297
HDAC3 10603
RPTOR 10704
SLC38A9 10806
WWP2 11033
MECOM 11343
PHC2 11404
RRAGA 11673
NEDD4 11742
RHEB 11794
PSME3 11914
EZH2 11944
JUN 12327
MKRN1 12656
PPARG 12902


Resolution of D-Loop Structures

Resolution of D-Loop Structures
21
set Resolution of D-Loop Structures
setSize 33
pANOVA 0.0141
s.dist 0.247
p.adjustANOVA 0.0154



Top enriched genes

Top 20 genes
GeneID Gene Rank
BRCA1 12034
SPIDR 11855
XRCC2 11778
RAD51 11519
EME1 11501
RTEL1 11476
RAD51D 11375
EXO1 11131
XRCC3 11016
GEN1 11003
RAD51C 10369
RAD51AP1 10287
BRIP1 10102
SLX4 9806
DNA2 9285
RMI1 8819
RAD51B 7849
BRCA2 6957
RAD50 5591
RMI2 2030

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA1 12034
SPIDR 11855
XRCC2 11778
RAD51 11519
EME1 11501
RTEL1 11476
RAD51D 11375
EXO1 11131
XRCC3 11016
GEN1 11003
RAD51C 10369
RAD51AP1 10287
BRIP1 10102
SLX4 9806
DNA2 9285
RMI1 8819
RAD51B 7849
BRCA2 6957
RAD50 5591
RMI2 2030
ATM -315
MRE11 -583
BLM -1084
MUS81 -2952
NBN -3704
EME2 -6251
SLX1A -7263
TOP3A -8197
BARD1 -8210
PALB2 -9628
RBBP8 -9854
KAT5 -10086
WRN -11561


Gene Silencing by RNA

Gene Silencing by RNA
4
set Gene Silencing by RNA
setSize 97
pANOVA 4.04e-05
s.dist -0.241
p.adjustANOVA 9.79e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2A -11973
H2BC12 -11952
PLD6 -11867
XPO5 -11808
NUP188 -11778
PRKRA -11751
NUP88 -11595
NUP98 -11474
AGO2 -11451
TNRC6B -11300
NUP54 -11190
H2BC15 -11065
NUP35 -10877
NUP50 -10860
NUP160 -10797
TSN -10758
H2BC5 -10738
AGO3 -10535
H2AC6 -10399
ELAC2 -10364

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2A -11973.0
H2BC12 -11952.0
PLD6 -11867.0
XPO5 -11808.0
NUP188 -11778.0
PRKRA -11751.0
NUP88 -11595.0
NUP98 -11474.0
AGO2 -11451.0
TNRC6B -11300.0
NUP54 -11190.0
H2BC15 -11065.0
NUP35 -10877.0
NUP50 -10860.0
NUP160 -10797.0
TSN -10758.0
H2BC5 -10738.0
AGO3 -10535.0
H2AC6 -10399.0
ELAC2 -10364.0
POLR2B -10329.0
SEC13 -10319.0
H2BC21 -10303.0
POLR2C -10068.0
POM121C -10022.0
H2BC11 -10016.0
SEH1L -9948.0
POLR2D -9853.0
H2BC4 -9514.0
POLR2F -9509.0
POM121 -9486.0
PIWIL4 -9437.0
NUP153 -9053.0
PIWIL2 -9021.0
ANG -8911.0
AGO1 -8274.0
NUP43 -8078.0
NUP58 -7953.0
RAE1 -7937.0
POLR2J -7484.0
NUP93 -7470.0
NUP214 -6849.0
RANBP2 -6437.0
NUP62 -6390.0
PIWIL1 -6298.0
NDC1 -6277.0
POLR2I -6204.0
POLR2G -6092.0
H2AZ1 -6085.0
RAN -5614.0
TNRC6C -5453.0
AAAS -5143.0
H2AC7 -5106.0
POLR2E -5082.0
H2BC17 -4694.0
H2BC13 -3705.0
TDRD9 -3702.0
ASZ1 -3320.0
FKBP6 -3272.0
H3C1 -1248.0
TARBP2 -678.0
H2AC18 -447.0
DDX4 -156.0
NUP155 1585.0
H2AB1 1716.0
MAEL 1994.0
TDRD6 1997.0
H3C15 2602.5
TNRC6A 2975.0
NUP37 3168.0
H2BC9 4973.0
H2AC20 4982.0
DGCR8 5564.0
NUP133 6353.0
TSNAX 6364.0
BCDIN3D 6735.0
POLR2H 7362.0
H2BU1 7827.0
NUP85 7952.0
POLR2K 8218.0
NUP42 8240.0
DROSHA 8625.0
AGO4 8669.0
TPR 8864.0
MYBL1 9045.0
IPO8 9264.0
DICER1 9661.0
H2AJ 10312.0
NUP107 10420.0
H3-3A 11070.0
HSP90AA1 11500.0
H2AZ2 11897.0
TDRKH 12162.0
POLR2L 12269.0
HENMT1 12296.0
NUP205 12472.0
NUP210 12959.0


Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
18
set Pyruvate metabolism and Citric Acid (TCA) cycle
setSize 52
pANOVA 0.00395
s.dist -0.231
p.adjustANOVA 0.00592



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPARD -11696
IDH2 -11636
ME2 -11619
PDHA1 -11291
MDH2 -11288
SLC16A1 -11189
SDHA -11107
RXRA -10594
SDHD -10258
CS -9888
DLD -9868
PDHX -9651
IDH3A -9507
PDP2 -9121
ME3 -9113
GLO1 -8983
DLST -8794
DLAT -8722
PDPR -7180
PDK3 -7147

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPARD -11696
IDH2 -11636
ME2 -11619
PDHA1 -11291
MDH2 -11288
SLC16A1 -11189
SDHA -11107
RXRA -10594
SDHD -10258
CS -9888
DLD -9868
PDHX -9651
IDH3A -9507
PDP2 -9121
ME3 -9113
GLO1 -8983
DLST -8794
DLAT -8722
PDPR -7180
PDK3 -7147
MPC1 -7093
SUCLG2 -6856
FAHD1 -6804
OGDH -5828
MPC2 -5588
BSG -5577
ACO2 -5458
PDK1 -5433
LDHA -5075
IDH3B -4657
PDHB -3628
LDHAL6A -1304
FH -414
SDHB -314
IDH3G 123
SUCLG1 1158
LDHB 3352
SUCLA2 3403
NNT 4578
ADHFE1 5130
LDHAL6B 5377
ME1 6924
L2HGDH 7195
D2HGDH 8631
SDHC 9448
HAGH 10117
VDAC1 10424
GSTZ1 10880
PDK4 11037
PDK2 11480
PDP1 11848
SLC16A3 11894


Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)
23
set Signaling by the B Cell Receptor (BCR)
setSize 106
pANOVA 4.08e-05
s.dist -0.231
p.adjustANOVA 9.79e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR1 -12150
NFATC2 -12008
FYN -12007
RELA -11521
PSMD14 -11242
NFKB1 -11227
PSME4 -11208
UBC -11024
PSMA7 -10789
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
NCK1 -10194
NFATC1 -9833
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR1 -12150
NFATC2 -12008
FYN -12007
RELA -11521
PSMD14 -11242
NFKB1 -11227
PSME4 -11208
UBC -11024
PSMA7 -10789
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
PSMA1 -10263
PSMD5 -10259
NCK1 -10194
NFATC1 -9833
PSMD1 -9807
PSMC2 -9799
PSMD8 -9715
PPP3CB -9584
NFATC3 -9423
PSMB7 -9263
PSME1 -9261
NFKBIB -9192
BCL10 -9066
NFKBIA -8797
PSMD3 -8656
HRAS -8652
ORAI1 -8619
ITPR2 -8235
PSMD9 -8231
PSMD6 -8169
PSMF1 -8140
RASGRP3 -7999
SOS1 -7836
PSMC4 -7727
PSMC6 -7633
REL -7523
PSMB5 -7489
PSMD10 -7419
UBA52 -7355
PSMD2 -7349
PSMB6 -7067
PLCG2 -6994
PSMD7 -6706
PSMB1 -6644
GRB2 -6642
PSMA3 -6131
UBB -6063
CD79A -5972
PPP3R1 -5775
PSMD13 -5738
FBXW11 -5544
BTRC -5265
VAV1 -4696
PSME2 -4577
MAP3K7 -4381
PSMA2 -4323
MALT1 -3995
PSMC1 -3828
PSMB2 -3623
PSMA6 -3583
NRAS -3563
NFKBIE -3528
CARD11 -3378
CHUK -2684
PSMB4 -1449
PSMC3 -1344
BTK -1057
BLK -649
SKP1 187
PSMD4 774
PSMD12 846
ITPR3 1010
PTPN6 3283
CD22 3686
PPIA 3841
RASGRP1 4701
RPS27A 5458
CD79B 5500
PSMA5 5639
AHCYL1 5822
TRPC1 6013
BLNK 6100
SH3KBP1 6392
PSMC5 7127
PSMD11 7823
PSMB3 8008
IKBKG 8177
PIK3CD 8228
PSMB10 9640
PIK3AP1 9834
ORAI2 10133
PIK3R1 10272
PPP3CA 10943
LYN 11297
CUL1 11299
CALM1 11432
SYK 11576
IKBKB 11671
PSME3 11914
FKBP1A 12058
STIM1 12444
PRKCB 12786
KRAS 12822


Mitochondrial biogenesis

Mitochondrial biogenesis
7
set Mitochondrial biogenesis
setSize 91
pANOVA 0.000304
s.dist -0.219
p.adjustANOVA 0.000662



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRTC3 -11927
SOD2 -11861
CARM1 -11838
PPARGC1B -11818
ESRRA -11780
TFB1M -11747
ACSS2 -11680
IDH2 -11636
NR1D1 -11623
PPRC1 -11464
TMEM11 -11373
CREBBP -11014
MTX2 -11011
SAMM50 -10867
RXRA -10594
MAPK14 -10203
NRF1 -10142
GLUD1 -10131
POLRMT -10042
ATF2 -9551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRTC3 -11927
SOD2 -11861
CARM1 -11838
PPARGC1B -11818
ESRRA -11780
TFB1M -11747
ACSS2 -11680
IDH2 -11636
NR1D1 -11623
PPRC1 -11464
TMEM11 -11373
CREBBP -11014
MTX2 -11011
SAMM50 -10867
RXRA -10594
MAPK14 -10203
NRF1 -10142
GLUD1 -10131
POLRMT -10042
ATF2 -9551
GABPA -9485
ATP5PO -9340
TBL1X -9175
TFB2M -9134
ATP5F1B -8985
PPARA -8971
NCOR1 -8803
ATP5MF -8735
MEF2C -8654
TGS1 -8307
PRKAB2 -8295
CRTC2 -8216
HSPA9 -7507
CRTC1 -7468
PRKAG1 -7333
NCOA2 -7246
ATP5MG -6969
ATP5PF -6964
MICOS13 -6905
APOO -6709
ATP5ME -6219
MAPK12 -5729
MTERF1 -5709
PRKAB1 -5632
GLUD2 -5626
CREB1 -5136
SIRT4 -4962
TBL1XR1 -4277
ATP5PD -4106
ATP5MC2 -4076
PRKAA2 -3530
SIRT3 -2841
TFAM -2477
CYCS -2193
GABPB1 -1820
SIRT5 -1721
ATP5F1E -1634
ATP5F1D -1303
NCOA6 -1275
APOOL -442
ATP5F1C -301
MEF2D -296
CHCHD6 2591
ATP5MC3 2830
ALAS1 4260
NCOA1 4354
MED1 4661
CHD9 6470
ATP5PB 6665
HELZ2 6840
PERM1 7070
CAMK4 7443
DNAJC11 7474
POLG2 7687
HCFC1 7834
ATP5F1A 8101
MT-ATP6 8523
MT-ATP8 9507
PRKAG2 9986
IMMT 10017
PPARGC1A 10547
HDAC3 10603
MICOS10 10608
MTX1 10656
CHCHD3 10751
MAPK11 10781
ATP5MC1 10858
DMAC2L 10970
CALM1 11432
SMARCD3 12081
SSBP1 12381


Mitochondrial protein import

Mitochondrial protein import
9
set Mitochondrial protein import
setSize 64
pANOVA 0.00596
s.dist -0.199
p.adjustANOVA 0.00842



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPD1 -12046
TIMM44 -11484
TOMM5 -11478
BCS1L -11212
HSCB -11093
MTX2 -11011
SAMM50 -10867
PITRM1 -10696
TOMM22 -10580
PAM16 -10391
TIMM50 -9917
CS -9888
TOMM6 -9737
CYC1 -9403
TIMM21 -9335
TIMM23 -9303
COA6 -9282
ATP5F1B -8985
PMPCB -8870
TIMM17B -8327

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -12046
TIMM44 -11484
TOMM5 -11478
BCS1L -11212
HSCB -11093
MTX2 -11011
SAMM50 -10867
PITRM1 -10696
TOMM22 -10580
PAM16 -10391
TIMM50 -9917
CS -9888
TOMM6 -9737
CYC1 -9403
TIMM21 -9335
TIMM23 -9303
COA6 -9282
ATP5F1B -8985
PMPCB -8870
TIMM17B -8327
CHCHD2 -8059
GFER -7914
CMC2 -7791
TIMM9 -7568
HSPA9 -7507
CMC4 -7486
GRPEL2 -6726
CHCHD5 -6490
CHCHD4 -6264
TIMM17A -5800
TOMM40 -5710
ACO2 -5458
TIMM8B -5212
GRPEL1 -5060
COA4 -4737
CHCHD10 -3164
TOMM20 -2687
TIMM10 -57
IDH3G 123
TIMM22 594
TOMM7 1305
SLC25A4 1790
TOMM70 2169
SLC25A6 2307
TIMM8A 2434
COQ2 3037
FXN 3074
PMPCA 4136
COX19 5356
TIMM13 7385
TIMM10B 7996
ATP5F1A 8101
TAZ 8321
NDUFB8 8470
DNAJC19 9265
SLC25A12 9539
CHCHD7 9917
VDAC1 10424
MTX1 10656
CHCHD3 10751
ATP5MC1 10858
LDHD 11798
COX17 11905
SLC25A13 12339


Oxidative Stress Induced Senescence

Oxidative Stress Induced Senescence
15
set Oxidative Stress Induced Senescence
setSize 82
pANOVA 0.00927
s.dist -0.166
p.adjustANOVA 0.0111



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2BC12 -11952
FOS -11578
TNRC6B -11300
SUZ12 -11232
H2BC15 -11065
CDKN2C -11041
UBC -11024
H2BC5 -10738
MAP2K4 -10695
CDK6 -10640
MINK1 -10571
AGO3 -10535
H2AC6 -10399
MAPK3 -10361
H2BC21 -10303
MAPK14 -10203
MAPKAPK3 -10028
H2BC11 -10016
MAP2K7 -9946
MAPK1 -9787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC12 -11952.0
FOS -11578.0
TNRC6B -11300.0
SUZ12 -11232.0
H2BC15 -11065.0
CDKN2C -11041.0
UBC -11024.0
H2BC5 -10738.0
MAP2K4 -10695.0
CDK6 -10640.0
MINK1 -10571.0
AGO3 -10535.0
H2AC6 -10399.0
MAPK3 -10361.0
H2BC21 -10303.0
MAPK14 -10203.0
MAPKAPK3 -10028.0
H2BC11 -10016.0
MAP2K7 -9946.0
MAPK1 -9787.0
CDKN2D -9744.0
H2BC4 -9514.0
MAP2K3 -9092.0
EED -8808.0
MAPKAPK5 -8752.0
AGO1 -8274.0
TXN -8043.0
PHC3 -8002.0
RBBP7 -7607.0
RNF2 -7600.0
UBA52 -7355.0
MAP3K5 -7060.0
BMI1 -6886.0
CBX6 -6492.0
H2AZ1 -6085.0
UBB -6063.0
RBBP4 -6029.0
TNRC6C -5453.0
H2AC7 -5106.0
H2BC17 -4694.0
TP53 -3707.0
H2BC13 -3705.0
MDM2 -3649.0
MAPKAPK2 -3571.0
MAPK8 -3464.0
MAP4K4 -3419.0
RING1 -3256.0
KDM6B -3081.0
E2F3 -2096.0
MAPK9 -1967.0
H3C1 -1248.0
H2AC18 -447.0
H2AB1 1716.0
H3C15 2602.5
TNRC6A 2975.0
MDM4 3290.0
H2BC9 4973.0
H2AC20 4982.0
CBX4 5340.0
RPS27A 5458.0
MOV10 6768.0
H2BU1 7827.0
SCMH1 7914.0
CBX2 8254.0
CBX8 8411.0
CDK4 8652.0
AGO4 8669.0
PHC1 8872.0
TFDP1 9916.0
MAP2K6 9945.0
H2AJ 10312.0
MAPK10 10498.0
MAPK11 10781.0
H3-3A 11070.0
PHC2 11404.0
H2AZ2 11897.0
EZH2 11944.0
E2F2 12035.0
TFDP2 12314.0
JUN 12327.0
E2F1 12383.0
TNIK 12707.0


Respiratory electron transport

Respiratory electron transport
22
set Respiratory electron transport
setSize 103
pANOVA 0.00651
s.dist -0.155
p.adjustANOVA 0.00865



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRAP1 -11824
UQCRC2 -11716
COQ10B -11698
UQCRFS1 -11542
ETFB -11539
NDUFA6 -11267
SCO1 -11258
NDUFAB1 -11185
SDHA -11107
SCO2 -10358
NDUFB10 -10304
SDHD -10258
NDUFS1 -10226
COX20 -9798
COX6B1 -9736
UQCR10 -9639
CYC1 -9403
NDUFA8 -9381
NDUFAF4 -9367
NDUFS3 -9260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRAP1 -11824
UQCRC2 -11716
COQ10B -11698
UQCRFS1 -11542
ETFB -11539
NDUFA6 -11267
SCO1 -11258
NDUFAB1 -11185
SDHA -11107
SCO2 -10358
NDUFB10 -10304
SDHD -10258
NDUFS1 -10226
COX20 -9798
COX6B1 -9736
UQCR10 -9639
CYC1 -9403
NDUFA8 -9381
NDUFAF4 -9367
NDUFS3 -9260
NDUFB9 -9151
NDUFB6 -8840
TMEM186 -8787
UQCRH -8637
TMEM126B -8634
NDUFS8 -8587
COX18 -8166
LRPPRC -8122
COX7B -7984
NDUFA10 -7818
COX8A -7804
NDUFC1 -7758
NDUFB11 -7657
NDUFV2 -7415
NDUFV3 -7326
NDUFA5 -7125
COX5B -7061
NDUFS5 -6917
ECSIT -6851
NDUFS6 -6845
NDUFA1 -6731
UQCR11 -6139
NDUFAF6 -6086
COX7A2L -5894
NDUFV1 -5849
COX14 -5734
NDUFC2 -5613
NDUFAF2 -5595
COX16 -5140
NDUFA3 -4876
NDUFA13 -4788
NDUFB7 -4549
ETFA -4021
NDUFAF5 -3737
NDUFB5 -3492
CYCS -2193
COX4I1 -1824
COX6A1 -1717
MT-ND2 -1543
UQCRB -1033
SDHB -314
MT-ND4 591
NDUFB3 1717
COQ10A 2125
ETFDH 2444
NDUFA9 2676
NDUFAF1 2954
COX11 3958
NDUFS2 4054
MT-ND5 4380
MT-ND6 4775
MT-ND1 5310
COX19 5356
COX6C 5569
NDUFS7 5632
NDUFA2 6039
MT-CYB 6093
NDUFS4 6490
MT-ND3 6673
NDUFA12 6823
NDUFAF7 6854
SURF1 8106
NUBPL 8142
NDUFB1 8195
TACO1 8342
MT-CO3 8348
NDUFB8 8470
UQCRC1 8691
MT-CO2 8706
COX5A 8723
NDUFA7 8975
NDUFB4 8991
MT-CO1 9170
NDUFA4 9235
TIMMDC1 9314
SDHC 9448
COX7C 9586
NDUFA11 9910
NDUFAF3 10278
UQCRQ 10347
NDUFB2 11470
COA1 11541
ACAD9 12560


Phospholipid metabolism

Phospholipid metabolism
17
set Phospholipid metabolism
setSize 186
pANOVA 0.000766
s.dist -0.143
p.adjustANOVA 0.00141



Top enriched genes

Top 20 genes
GeneID Gene Rank
PLEKHA2 -12078
GPCPD1 -11989
PLA2G4A -11980
STARD10 -11907
PLA2G5 -11890
DDHD2 -11888
PLD6 -11867
AGPAT5 -11821
AGPAT4 -11683
MFSD2A -11639
DGAT2 -11600
AGPAT3 -11492
LPCAT4 -11441
LPIN1 -11422
PITPNB -11359
MTMR12 -11245
CSNK2A1 -11231
PISD -11174
PIKFYVE -11015
PNPLA8 -10907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLEKHA2 -12078
GPCPD1 -11989
PLA2G4A -11980
STARD10 -11907
PLA2G5 -11890
DDHD2 -11888
PLD6 -11867
AGPAT5 -11821
AGPAT4 -11683
MFSD2A -11639
DGAT2 -11600
AGPAT3 -11492
LPCAT4 -11441
LPIN1 -11422
PITPNB -11359
MTMR12 -11245
CSNK2A1 -11231
PISD -11174
PIKFYVE -11015
PNPLA8 -10907
TNFAIP8L1 -10591
CSNK2A2 -10568
CPNE3 -10528
PITPNM1 -10451
MBOAT2 -10407
VAC14 -10370
PLEKHA3 -10270
PNPLA3 -10234
PNPLA6 -10196
GPAT4 -10070
MTMR9 -9965
CSNK2B -9864
INPP5E -9846
PIK3CB -9832
CHKA -9810
ARF1 -9777
RAB14 -9776
CRLS1 -9677
TNFAIP8 -9479
PLEKHA5 -9438
MIGA2 -9434
GDPD3 -9421
CDIPT -9346
PLA2G6 -9314
DDHD1 -9060
OSBPL5 -8967
PIK3C3 -8770
RAB5A -8437
MTMR3 -8430
PCYT2 -8377
INPPL1 -8304
AGPAT2 -8177
SBF2 -8171
CPNE1 -8148
SACM1L -8144
PIP5K1C -8116
MBOAT1 -7952
PLD2 -7901
PI4K2A -7860
SBF1 -7574
INPP4A -7501
SYNJ1 -7491
PTEN -7485
ETNK1 -7425
PNPLA2 -7169
PLA2G15 -7084
OSBPL8 -7051
PIK3R2 -7036
PTPMT1 -7015
SELENOI -6841
INPP5F -6783
PITPNM2 -6665
MTMR2 -6596
LPCAT2 -6322
PLEKHA1 -6310
PEMT -6269
LCLAT1 -6241
PIK3C2A -6065
CDS1 -5995
GDE1 -5942
PIK3CA -5872
MTMR6 -5829
PGS1 -5625
MTMR14 -5593
GDPD5 -5476
MTMR7 -5430
MTMR4 -5347
MIGA1 -5290
PTDSS1 -5236
TMEM86B -5072
MTM1 -4959
PI4K2B -4728
PHOSPHO1 -4713
ABHD4 -4407
OCRL -4220
GPAT2 -3896
PIP4K2B -3666
DGAT1 -3633
GPAT3 -3380
PLEKHA4 -3293
LPCAT1 -3253
GNPAT -3252
CHPT1 -2852
CEPT1 -2758
RUFY1 -2514
INPP5K -2299
PIK3R5 -1878
PLB1 -696
HADHB -448
GPD1L -411
ENPP6 -398
GPD1 1
CPNE7 227
PLA2G10 315
PITPNM3 478
PLA1A 1141
PCYT1A 1529
PLA2G4D 1688
PLAAT1 2456
PLD4 2642
INPP5J 2845
SLC44A1 3105
LPIN3 3318
ARF3 3329
LIPH 3538
ABHD3 3630
MBOAT7 4194
ETNK2 4224
PNPLA7 4476
PLEKHA8 5132
STARD7 5329
PI4KB 5840
PLA2G4B 6302
PIP5K1B 6320
TNFAIP8L3 6395
RAB4A 6572
GDPD1 6640
CHAT 6879
BCHE 7441
PIP5K1A 7531
PIK3C2B 7613
SYNJ2 7650
LPIN2 7664
INPP4B 7902
PIK3CD 8228
TAZ 8321
PIP4K2A 8339
PIK3CG 8479
PIP4K2C 8528
GPD2 8797
PLA2G12A 8863
SLC44A5 8912
GPAM 9450
PLD3 9634
PIK3R4 9714
PIK3R3 9757
LPGAT1 9892
SLC44A3 9949
MTMR10 10042
ACHE 10051
PLA2G4C 10084
FIG4 10238
PIK3R1 10272
PLAAT4 10513
MTMR1 10551
PI4KA 10606
HADHA 10699
PTDSS2 10901
PLEKHA6 11040
CHKB 11309
SLC44A2 11526
PCTP 12318
LPCAT3 12409
AGK 12419
AGPAT1 12443
ACP6 12466
OSBPL10 12525
PLA2R1 12556
INPP5D 12597
CDS2 12598
PLBD1 12610
PTPN13 12725
PIK3R6 12819
MGLL 12829
PLD1 12869
PLAAT3 12981


Mitochondrial translation

Mitochondrial translation
10
set Mitochondrial translation
setSize 96
pANOVA 0.0158
s.dist -0.142
p.adjustANOVA 0.0165



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS6 -11351
MRPL2 -11139
MRPS30 -11130
MRPS18B -11057
MRPL44 -10975
MRPS34 -10922
MRPS35 -10918
MRPL32 -10786
MRPS26 -10783
MRPL36 -10468
MRPL49 -10435
MRPL46 -10105
MRPS5 -9849
MRPS12 -9455
TUFM -9026
MRPL50 -8844
MRPS11 -8763
MRPL4 -8719
MRPL18 -8598
MRPL17 -8111

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS6 -11351
MRPL2 -11139
MRPS30 -11130
MRPS18B -11057
MRPL44 -10975
MRPS34 -10922
MRPS35 -10918
MRPL32 -10786
MRPS26 -10783
MRPL36 -10468
MRPL49 -10435
MRPL46 -10105
MRPS5 -9849
MRPS12 -9455
TUFM -9026
MRPL50 -8844
MRPS11 -8763
MRPL4 -8719
MRPL18 -8598
MRPL17 -8111
MRPS24 -8066
MRPL39 -7920
MRPL28 -7881
GADD45GIP1 -7879
MRPL48 -7695
MRPL34 -7662
MRPL15 -7618
MRPL41 -7446
MRPL14 -7389
MRPS22 -7223
MRPL21 -6983
MRPS18C -6694
MTRF1L -6592
MRPS10 -6166
MRPS9 -6136
MT-RNR1 -5658
MRPL11 -5539
TSFM -5519
MRPL22 -5233
MTFMT -5146
MRPL19 -5118
MRPL37 -5051
MRPL54 -4913
MRPL3 -4849
MRPL30 -4480
MTIF3 -4433
MRPL58 -4276
DAP3 -4049
MRPS31 -3773
MRPL20 -3484
MRPL9 -3449
MRPL35 -2978
MRPS23 -2828
MRPL51 -2169
MRPL24 -1660
MT-RNR2 -1462
MRPL40 -489
MRPS18A -441
MRPL38 -390
AURKAIP1 -142
MRPS15 845
MRPS17 986
MRPS2 1805
MRPL42 2531
MRPS25 2730
MRPL12 3529
MRRF 3979
PTCD3 4421
MRPL47 4910
MRPL55 4935
MRPL16 6240
MRPL45 6266
MRPS14 6317
MRPL13 6397
MRPL10 7141
MRPS21 7217
MRPL43 7360
MRPL23 7526
MRPL1 7938
MTIF2 7960
MRPS36 8061
MRPS16 9006
CHCHD1 9234
MRPS28 9323
MRPL27 9492
ERAL1 10107
MRPS7 10196
MRPL53 10209
MRPS33 10546
MRPS27 10691
MRPL57 10793
GFM1 10843
MRPL52 10881
MRPL33 11029
OXA1L 12260
GFM2 12344


Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives
6
set Metabolism of amino acids and derivatives
setSize 339
pANOVA 8.34e-06
s.dist -0.141
p.adjustANOVA 2.86e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ODC1 -12175
SAT1 -12143
ARG2 -12119
GSR -12060
ECHS1 -12038
SMS -11794
IL4I1 -11726
TXNRD1 -11591
ASNS -11505
SERINC5 -11482
ENOPH1 -11412
PDHA1 -11291
ACAT1 -11265
CPS1 -11257
PSMD14 -11242
PSME4 -11208
NDUFAB1 -11185
RPS17 -11161
RPL22L1 -11075
ETHE1 -11058

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ODC1 -12175
SAT1 -12143
ARG2 -12119
GSR -12060
ECHS1 -12038
SMS -11794
IL4I1 -11726
TXNRD1 -11591
ASNS -11505
SERINC5 -11482
ENOPH1 -11412
PDHA1 -11291
ACAT1 -11265
CPS1 -11257
PSMD14 -11242
PSME4 -11208
NDUFAB1 -11185
RPS17 -11161
RPL22L1 -11075
ETHE1 -11058
PAPSS1 -10933
KARS1 -10869
RPS2 -10847
EEF1E1 -10829
PSMA7 -10789
GCAT -10649
DARS1 -10628
SEM1 -10597
PSMA4 -10526
PSMB9 -10429
PSMB8 -10402
RARS1 -10339
RPL10A -10326
SERINC3 -10307
RPL9 -10276
PSMA1 -10263
PSMD5 -10259
GLUD1 -10131
SCLY -10098
RPS13 -10067
RPL26L1 -10003
RPS25 -9987
RPL34 -9972
GLS -9971
RPL37A -9962
RPL12 -9944
SLC3A2 -9934
DLD -9868
PPM1K -9867
RPS6 -9840
PSMD1 -9807
PSMC2 -9799
RPS3A -9784
RPS18 -9734
LIAS -9717
PSMD8 -9715
SLC7A5 -9688
PDHX -9651
AMD1 -9632
AIMP1 -9617
RPL17 -9599
ALDH18A1 -9494
AZIN1 -9487
RPL36 -9425
RPS9 -9422
RPL26 -9404
RPL31 -9388
RPS15A -9361
TXN2 -9301
PSMB7 -9263
PSME1 -9261
FAU -9217
PSAT1 -9182
SERINC1 -9166
RPS4X -9149
RPL11 -9136
RPS10 -8990
RIMKLB -8917
MTRR -8887
MRI1 -8865
DIO2 -8856
RPLP2 -8827
RPL36AL -8817
DLST -8794
LIPT1 -8780
DLAT -8722
PSMD3 -8656
SLC25A15 -8649
RPL35 -8625
LARS1 -8597
RPS12 -8467
RPL27A -8412
RPS3 -8350
RPS11 -8319
BCAT1 -8237
PSMD9 -8231
RPS19 -8226
PSMD6 -8169
RPL8 -8164
PSMF1 -8140
FOLH1 -8114
RPS15 -8015
CARNMT1 -7965
ALDH6A1 -7801
PSMC4 -7727
SRM -7720
PSMC6 -7633
CRYM -7625
RPL18A -7530
PSMB5 -7489
RPL6 -7455
PSMD10 -7419
RPL13A -7403
RPL3 -7375
UBA52 -7355
PSMD2 -7349
GCSH -7307
FAH -7209
RPL18 -7207
RPL39L -7141
NMRAL1 -7112
BCAT2 -7079
PSMB6 -7067
SEPSECS -6972
RPL14 -6909
RPL21 -6840
RPS5 -6800
GRHPR -6724
PSMD7 -6706
RPL39 -6675
RPL7A -6670
SRR -6666
PSMB1 -6644
MAT1A -6593
OAZ1 -6494
RPS8 -6290
RPL28 -6287
KYAT1 -6188
PSMA3 -6131
RPL22 -6014
OGDH -5828
PSMD13 -5738
APIP -5707
GLUD2 -5626
RPL32 -5445
RPS20 -5374
PYCR1 -5340
OAZ3 -5067
AFMID -5054
RPL37 -5004
RPL41 -4994
RPL24 -4966
RPL29 -4883
RPL36A -4846
AGXT -4814
HYKK -4750
MPST -4729
SLC6A12 -4591
PSME2 -4577
NAT8L -4538
BCKDK -4506
PSMA2 -4323
SMOX -4315
RPL30 -4218
RPS16 -4149
RPL10 -4126
DBT -4084
ADI1 -3862
PSMC1 -3828
DCT -3818
RPL13 -3746
PDHB -3628
PSMB2 -3623
PSMA6 -3583
RPL7 -3582
HAL -3519
CSAD -3474
CTH -3291
RPS21 -3225
HIBCH -2855
CKM -2843
RPS26 -2804
KYNU -2679
LIPT2 -2437
SERINC4 -2339
IARS1 -2337
AASS -2179
DHTKD1 -1925
HNMT -1751
SLC36A4 -1699
RPLP0 -1594
MARS1 -1565
RPL35A -1535
GNMT -1454
PSMB4 -1449
PSMC3 -1344
RPS14 -1250
GADL1 -837
RPL15 -826
RPS29 -684
CBSL -614
ALDH9A1 -588
BHMT -574
RPL3L -537
IYD -367
TPH2 -323
GOT1 -265
RIDA -78
MTR 96
RPSA 306
RPS27 679
PSMD4 774
PSMD12 846
AGMAT 1036
DUOX2 1229
HOGA1 1344
AHCY 1391
EPRS1 1414
RPL38 1610
ARG1 1771
AIMP2 1934
HPD 1974
SLC25A21 2002
DDO 2124
HIBADH 2154
RPS24 2437
HSD17B10 2691
RPS28 2787
SLC44A1 3105
PIPOX 3404
AZIN2 3881
SDS 3895
RPL19 4011
TPH1 4063
GLDC 4104
TPO 4159
IDO2 4356
PRODH 4746
RPL5 4778
TAT 4798
CGA 4884
CKMT2 4994
MTAP 5234
RPS7 5242
RPS27A 5458
ASPA 5504
PSMA5 5639
AUH 5820
PSTK 5857
SLC5A5 5861
RPL23 5870
GCDH 6137
PNMT 6277
RPL27 6838
AMT 6848
ADO 6880
PAPSS2 6950
FTCD 6958
DUOX1 7039
RPS23 7043
CARNS1 7093
PSMC5 7127
RPS27L 7433
KMO 7493
NAALAD2 7771
PSMD11 7823
PSMB3 8008
SEPHS2 8206
MCCC2 8387
GPT2 8468
ACADSB 8489
SLC25A44 8542
BCKDHA 8561
HAAO 8791
GPT 8968
TDO2 9017
RPLP1 9129
ASRGL1 9339
DMGDH 9418
GLS2 9469
SLC25A12 9539
INMT 9547
PSMB10 9640
PYCR2 9868
DBH 10003
TST 10060
SHMT1 10144
QARS1 10237
PAOX 10376
PHGDH 10484
KYAT3 10519
PCBD1 10545
SLC25A10 10638
TMLHE 10663
BCKDHB 10678
ALDH7A1 10696
PXMP2 10733
AADAT 10775
SARS1 10851
GSTZ1 10880
SLC6A11 10888
CBS 11010
OAT 11026
CKMT1A 11061
CKB 11236
ALDH4A1 11249
AMDHD1 11258
GOT2 11276
EEFSEC 11287
SECISBP2 11310
GAMT 11313
OCA2 11415
ACAD8 11450
RPL4 11454
QDPR 11463
RPL23A 11464
PSPH 11525
ASS1 11624
SDSL 11753
SARDH 11900
PSME3 11914
SUOX 11922
NAGS 11990
GATM 12050
AANAT 12113
IVD 12224
CHDH 12238
MCCC1 12328
SLC25A13 12339
OAZ2 12408
SLC6A8 12520
BHMT2 12554
NQO1 12600
ASL 12604
GLUL 12634
PHYKPL 12753
RIMKLA 12851
NNMT 12863
SERINC2 13004


Nervous system development

Nervous system development
13
set Nervous system development
setSize 526
pANOVA 2.94e-06
s.dist -0.119
p.adjustANOVA 1.41e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MMP9 -12171
SEMA5A -12164
NRP2 -12130
EPHB6 -12128
DLG4 -12115
ARPC1B -12100
EPHA4 -12092
PAK1 -12091
ITGA10 -12065
ITGA5 -12054
SRC -12015
FYN -12007
SLIT2 -11992
NUMB -11979
EZR -11915
MYO10 -11910
CYP51A1 -11879
CLTA -11697
EPHB4 -11695
NAB2 -11649

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMP9 -12171
SEMA5A -12164
NRP2 -12130
EPHB6 -12128
DLG4 -12115
ARPC1B -12100
EPHA4 -12092
PAK1 -12091
ITGA10 -12065
ITGA5 -12054
SRC -12015
FYN -12007
SLIT2 -11992
NUMB -11979
EZR -11915
MYO10 -11910
CYP51A1 -11879
CLTA -11697
EPHB4 -11695
NAB2 -11649
GSPT1 -11645
RELN -11629
RNPS1 -11608
EPHB2 -11602
MYO9B -11582
YES1 -11530
SREBF2 -11460
HSPA8 -11386
CACNB3 -11377
ARPC2 -11353
RRAS -11338
PSMD14 -11242
FGFR1 -11240
CSNK2A1 -11231
PSME4 -11208
RPS17 -11161
ARPC1A -11108
MYH9 -11097
RPL22L1 -11075
UBC -11024
DOK4 -11022
CXCL12 -11000
TLN1 -10941
RPS2 -10847
PSMA7 -10789
NCK2 -10735
DOK5 -10730
ITSN1 -10717
COL9A3 -10702
SEM1 -10597
CSNK2A2 -10568
HMGCR -10560
PSMA4 -10526
PSMB9 -10429
HDAC2 -10405
PSMB8 -10402
MAPK3 -10361
RPL10A -10326
COL4A4 -10325
ELOB -10320
RPL9 -10276
PSMA1 -10263
PSMD5 -10259
MAPK14 -10203
NCK1 -10194
SHC3 -10168
CRMP1 -10084
RGMA -10077
RPS13 -10067
DLG1 -10024
RPL26L1 -10003
RPS25 -9987
RPL34 -9972
RPL37A -9962
RPL12 -9944
RBX1 -9931
CSNK2B -9864
RPS6 -9840
PIK3CB -9832
VASP -9824
PSMD1 -9807
PSMC2 -9799
MAPK1 -9787
RPS3A -9784
HSP90AB1 -9782
PTK2 -9781
RPS18 -9734
PSMD8 -9715
LAMB1 -9699
RPL17 -9599
CDK5R1 -9590
PPP3CB -9584
PAK4 -9557
FES -9532
RPS6KA5 -9477
RPL36 -9425
RPS9 -9422
NTN4 -9411
RPL26 -9404
RPL31 -9388
RPS15A -9361
LAMA2 -9336
CACNB4 -9315
WASL -9275
PSMB7 -9263
PSME1 -9261
FAU -9217
GAB2 -9209
DRP2 -9202
SCD5 -9169
RPS4X -9149
RPL11 -9136
MAP2K2 -9133
SEMA3A -9127
PLCG1 -9125
DPYSL2 -9122
DNM2 -9093
UPF3A -9016
RPS10 -8990
RPS6KA2 -8984
RPS6KA3 -8960
ARPC3 -8907
RPLP2 -8827
RPL36AL -8817
PRNP -8739
EFNA3 -8723
MYL12B -8681
PSMD3 -8656
HRAS -8652
RPL35 -8625
ACTR3 -8581
MAPK7 -8578
SDCBP -8530
RPS12 -8467
ROBO3 -8466
TRPC4 -8452
CDC42 -8414
RPL27A -8412
NAB1 -8390
RND1 -8382
NCBP1 -8378
MAGOHB -8363
RPS3 -8350
RPS11 -8319
SIAH2 -8301
PSMD9 -8231
RPS19 -8226
RDX -8220
PSMD6 -8169
RPL8 -8164
RANBP9 -8154
GRB7 -8152
PSMF1 -8140
PIP5K1C -8116
RAC1 -8060
UNC5B -8055
VAV3 -8040
MYH14 -8039
RPS15 -8015
RHOA -7994
ELOC -7977
KALRN -7936
PLXNA3 -7931
COL6A3 -7863
PRX -7861
FLRT3 -7848
SOS1 -7836
GRB10 -7819
UNC5D -7748
PSMC4 -7727
PSMC6 -7633
CNTN6 -7602
SCN1B -7597
PABPC1 -7595
AP2A1 -7556
CLTCL1 -7531
RPL18A -7530
PSMB5 -7489
RPL6 -7455
PTPN11 -7428
ABL2 -7427
PSMD10 -7419
RPL13A -7403
RPL3 -7375
UBA52 -7355
PSMD2 -7349
CLASP1 -7339
RHOC -7311
SDC2 -7298
RPL18 -7207
GAB1 -7195
EFNB2 -7168
RPL39L -7141
AP2A2 -7069
PSMB6 -7067
PIK3R2 -7036
FRS2 -6984
NRTN -6949
RPL14 -6909
NCBP2 -6900
PAK2 -6893
ROBO2 -6879
COL4A3 -6869
RPL21 -6840
PDLIM7 -6815
RPS5 -6800
CXCR4 -6790
PSMD7 -6706
RPL39 -6675
RPL7A -6670
PSMB1 -6644
GRB2 -6642
PSPN -6641
MYL6 -6636
SPTBN4 -6588
DSCAML1 -6569
LIMK2 -6526
PRKAR2A -6478
EFNA4 -6467
SEMA6D -6420
KCNQ2 -6417
ITGA2B -6364
SRGAP1 -6332
RPS8 -6290
RPL28 -6287
RGMB -6200
PSEN1 -6133
PSMA3 -6131
MAGOH -6068
UBB -6063
YAP1 -6031
RPL22 -6014
ETF1 -5970
GSPT2 -5964
CACNA1I -5906
NCAM1 -5879
PIK3CA -5872
ENAH -5864
TEAD1 -5845
PSMD13 -5738
MAPK12 -5729
SCN3A -5502
RPL32 -5445
RPS20 -5374
PLXNB1 -5353
ARHGEF12 -5270
CAP1 -5254
CREB1 -5136
ARPC4 -5117
ROBO1 -5110
GFRA1 -5050
RPL37 -5004
RPL41 -4994
RPL24 -4966
RPL29 -4883
RPL36A -4846
NFASC -4768
CLTB -4654
VAV2 -4605
PSME2 -4577
ISL1 -4551
PSMA2 -4323
SCN3B -4310
RPL30 -4218
RPS16 -4149
RPL10 -4126
ROCK1 -4110
MYH11 -4099
SMARCA4 -3969
ITGB1 -3944
PSMC1 -3828
RPL13 -3746
PSMB2 -3623
PSMA6 -3583
RPL7 -3582
NRAS -3563
EPHA5 -3509
EPHA8 -3508
MAPK8 -3464
UPF3B -3267
RPS21 -3225
CACNB2 -3118
CLASP2 -2947
MBP -2867
RPS26 -2804
PTPRC -2719
TRPC3 -2464
RPS6KA6 -2383
SCN2B -2333
SCN7A -2223
CUL2 -2175
CD24 -2139
IRS2 -2072
ST8SIA2 -1691
PLXNA2 -1659
RPLP0 -1594
PFN1 -1591
CAP2 -1588
RPL35A -1535
PSMB4 -1449
PSMC3 -1344
SCN11A -1267
RPS14 -1250
SPTAN1 -1141
PMP22 -1010
RPL15 -826
RPS29 -684
EIF4A3 -659
CD72 -658
RPL3L -537
MAPK13 -502
SPTBN5 -499
RET -93
GRIN2B -92
SEMA4A -33
CFL1 127
ITGAV 152
PTPRA 200
RPS6KA4 218
RPSA 306
CNTN2 657
RPS27 679
EPHA7 706
PSMD4 774
PSMD12 846
EGR2 995
SCN2A 1051
DOK1 1444
GIT1 1475
RPL38 1610
ACTR2 1770
GRIN1 1830
PAK6 1940
USP33 1973
GPC1 2014
EGFR 2192
RPS24 2437
DPYSL4 2739
ARHGAP39 2775
RPS28 2787
DCC 3020
APH1A 3219
COL6A6 3565
NCAN 3613
CASC3 3703
ERBB2 3902
RPL19 4011
POU3F1 4030
ARTN 4069
LDB1 4235
RPL5 4778
EPHA10 4921
ARHGEF7 4937
EFNA2 4939
RPS7 5242
ABLIM3 5248
RPS27A 5458
PSMA5 5639
EPHB3 5761
LYPLA2 5764
EPHA1 5847
RPL23 5870
DOK6 5876
ANK1 5962
TRPC1 6013
SIAH1 6183
DAG1 6250
SCN9A 6286
SH3KBP1 6392
ARPC5 6573
COL9A2 6693
RPL27 6838
EFNB3 6870
UPF2 6960
ANK3 6985
AKAP5 7033
RPS23 7043
GSK3B 7119
PSMC5 7127
FARP2 7144
DNM3 7371
RPS27L 7433
NGEF 7494
CNTNAP1 7549
CLTC 7722
MYL9 7731
KIF4A 7735
PSMD11 7823
PLXNC1 7885
PITPNA 7984
PSMB3 8008
CACNB1 8112
ITGA2 8165
PSENEN 8173
ST8SIA4 8202
PIK3CD 8228
PRKACA 8353
MYL12A 8447
RBM8A 8550
ABLIM2 8602
SPTB 8754
ALCAM 8766
LIMK1 8794
PRKACB 8952
AP2S1 8984
HOXA2 9001
DPYSL3 9065
RASA1 9084
DLG3 9114
RPLP1 9129
SEMA7A 9246
EIF4G1 9262
ANK2 9303
LHX9 9340
SH3GL2 9345
EPHA6 9357
ARHGEF11 9412
SCN8A 9413
UTRN 9536
ARHGEF28 9569
DAB1 9613
PSMB10 9640
MSI1 9676
KCNQ3 9709
PIK3R3 9757
EVL 9847
SOS2 9864
VLDLR 9877
NRCAM 9947
PAK3 10002
SEMA4D 10006
PSEN2 10190
SRGAP3 10240
TRIO 10252
AP2M1 10254
PRKCQ 10262
PIK3R1 10272
ACTB 10353
DOCK1 10367
LHX2 10411
EFNA1 10423
SCN5A 10457
PAK5 10492
MAP2K1 10510
MYH10 10515
PFN2 10593
ACTG1 10622
WWTR1 10675
CNTN1 10727
MAPK11 10781
ZSWIM8 10804
EFNB1 10815
MSN 10855
ARHGAP35 10866
MET 10899
SPTBN2 10923
RAP1GAP 10994
SHANK3 11096
UNC5C 11098
TIAM1 11180
LYN 11297
ADGRV1 11302
PLXNB3 11451
RPL4 11454
CACNA1C 11460
RPL23A 11464
CDK5 11468
HSP90AA1 11500
POU3F2 11503
SRGAP2 11522
COL6A1 11623
PLXND1 11660
NCSTN 11666
LHX4 11667
EPHB1 11679
SCN4B 11736
ABL1 11766
PLXNA4 11829
DNM1 11833
ADAM10 11835
PSME3 11914
CACNA1H 11956
SHTN1 12069
COL6A2 12141
COL6A5 12146
GFRA2 12203
DPYSL5 12211
APH1B 12241
ABLIM1 12243
COL4A1 12247
CACNA1G 12307
SPTBN1 12309
CACNA1D 12354
ITGA1 12361
COL4A2 12390
AGAP2 12405
ROCK2 12406
NEO1 12413
SLIT1 12441
PRKCA 12469
COL4A5 12479
AP2B1 12530
MMP2 12532
NRP1 12595
AGRN 12621
UNC5A 12641
SHC1 12652
ADGRG6 12674
RHOB 12678
SLIT3 12724
L1CAM 12776
ITGB3 12791
NELL2 12796
GAP43 12806
KRAS 12822
EFNA5 12871
EPHA2 12873
NTN1 12880
ITGA9 12894
LAMA1 12905
GDNF 12916
RPS6KA1 12921
SEMA6A 12927
PLXNA1 12937
LAMC1 12957
CACNA1S 12992


Complex I biogenesis

Complex I biogenesis
2
set Complex I biogenesis
setSize 57
pANOVA 0.125
s.dist -0.117
p.adjustANOVA 0.125



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFA6 -11267
NDUFAB1 -11185
NDUFB10 -10304
NDUFS1 -10226
NDUFA8 -9381
NDUFAF4 -9367
NDUFS3 -9260
NDUFB9 -9151
NDUFB6 -8840
TMEM186 -8787
TMEM126B -8634
NDUFS8 -8587
NDUFA10 -7818
NDUFC1 -7758
NDUFB11 -7657
NDUFV2 -7415
NDUFV3 -7326
NDUFA5 -7125
NDUFS5 -6917
ECSIT -6851

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA6 -11267
NDUFAB1 -11185
NDUFB10 -10304
NDUFS1 -10226
NDUFA8 -9381
NDUFAF4 -9367
NDUFS3 -9260
NDUFB9 -9151
NDUFB6 -8840
TMEM186 -8787
TMEM126B -8634
NDUFS8 -8587
NDUFA10 -7818
NDUFC1 -7758
NDUFB11 -7657
NDUFV2 -7415
NDUFV3 -7326
NDUFA5 -7125
NDUFS5 -6917
ECSIT -6851
NDUFS6 -6845
NDUFA1 -6731
NDUFAF6 -6086
NDUFV1 -5849
NDUFC2 -5613
NDUFAF2 -5595
NDUFA3 -4876
NDUFA13 -4788
NDUFB7 -4549
NDUFAF5 -3737
NDUFB5 -3492
MT-ND2 -1543
MT-ND4 591
NDUFB3 1717
NDUFA9 2676
NDUFAF1 2954
NDUFS2 4054
MT-ND5 4380
MT-ND6 4775
MT-ND1 5310
NDUFS7 5632
NDUFA2 6039
NDUFS4 6490
MT-ND3 6673
NDUFA12 6823
NDUFAF7 6854
NUBPL 8142
NDUFB1 8195
NDUFB8 8470
NDUFA7 8975
NDUFB4 8991
TIMMDC1 9314
NDUFA11 9910
NDUFAF3 10278
NDUFB2 11470
COA1 11541
ACAD9 12560


Metabolism

Metabolism
5
set Metabolism
setSize 1871
pANOVA 0.000595
s.dist -0.0476
p.adjustANOVA 0.00119



Top enriched genes

Top 20 genes
GeneID Gene Rank
HAS2 -12188
ODC1 -12175
PRSS3 -12161
QPRT -12159
BPGM -12156
HS3ST3B1 -12154
ITPR1 -12150
CA9 -12145
SAT1 -12143
GK -12133
ARG2 -12119
CMBL -12102
ST3GAL6 -12085
PLEKHA2 -12078
FDFT1 -12075
HS3ST3A1 -12068
GSR -12060
OSBP -12059
ACAN -12058
SEC24D -12057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HAS2 -12188
ODC1 -12175
PRSS3 -12161
QPRT -12159
BPGM -12156
HS3ST3B1 -12154
ITPR1 -12150
CA9 -12145
SAT1 -12143
GK -12133
ARG2 -12119
CMBL -12102
ST3GAL6 -12085
PLEKHA2 -12078
FDFT1 -12075
HS3ST3A1 -12068
GSR -12060
OSBP -12059
ACAN -12058
SEC24D -12057
ECHS1 -12038
PPP2R5D -12010
B4GALT1 -12002
PPP2CB -12001
GPCPD1 -11989
PGM2 -11985
PLA2G4A -11980
CHPF -11974
ADCY7 -11944
PYGB -11923
STARD10 -11907
AKR1C3 -11904
NCOA3 -11897
PGM2L1 -11893
PLA2G5 -11890
DDHD2 -11888
SQLE -11884
CYP51A1 -11879
PLD6 -11867
ABHD10 -11858
LPL -11839
CARM1 -11838
ADCY2 -11830
TRAP1 -11824
AGPAT5 -11821
SPHK1 -11820
PPARGC1B -11818
IQGAP1 -11815
HMOX1 -11813
ENTPD3 -11807
SMS -11794
GNG11 -11792
ESRRA -11780
NUP188 -11778
FUT4 -11730
IL4I1 -11726
GLIPR1 -11722
UQCRC2 -11716
XYLT1 -11708
ELOVL1 -11699
COQ10B -11698
PPARD -11696
ITPKC -11690
AGPAT4 -11683
ACSS2 -11680
PDXK -11662
MFSD2A -11639
IDH2 -11636
AK5 -11633
NR1D1 -11623
ME2 -11619
NUDT11 -11618
DGAT2 -11600
NUP88 -11595
TXNRD1 -11591
ACAT2 -11587
ATIC -11566
UQCRFS1 -11542
ETFB -11539
MSMO1 -11523
GART -11514
ASNS -11505
AGPAT3 -11492
SERINC5 -11482
NUP98 -11474
POR -11469
GNB2 -11463
SREBF2 -11460
LPCAT4 -11441
CSGALNACT2 -11435
ALDOA -11423
LPIN1 -11422
NFYA -11413
ENOPH1 -11412
MMAA -11408
STX1A -11406
PRPS2 -11404
CYP1B1 -11392
ACSL1 -11388
CACNB3 -11377
SYT5 -11376
PITPNB -11359
ADPRM -11295
PDHA1 -11291
MDH2 -11288
MED10 -11274
NDUFA6 -11267
ACAT1 -11265
SCO1 -11258
CPS1 -11257
DHCR7 -11247
MTMR12 -11245
ORMDL1 -11243
PSMD14 -11242
CRYL1 -11236
RDH11 -11234
CSNK2A1 -11231
COX10 -11224
LRP12 -11222
PSME4 -11208
GPX4 -11193
NUP54 -11190
SLC16A1 -11189
NDUFAB1 -11185
VKORC1L1 -11181
PISD -11174
ITPKA -11167
HMGCS1 -11163
RPS17 -11161
NEU3 -11152
ENTPD4 -11128
UBE2I -11116
SDHA -11107
OSBPL6 -11106
HSCB -11093
HMOX2 -11081
RPL22L1 -11075
ETHE1 -11058
UBC -11024
CTPS2 -11020
PIKFYVE -11015
CREBBP -11014
MANBA -11003
TSPO -10997
ST6GALNAC6 -10992
ABCC1 -10971
DSEL -10969
TKT -10942
PAPSS1 -10933
KDSR -10910
PNPLA8 -10907
TPST2 -10879
NUP35 -10877
SEC24B -10875
KARS1 -10869
NUP50 -10860
RPS2 -10847
FUT10 -10838
PTGES -10830
EEF1E1 -10829
DCK -10823
NUP160 -10797
AMN -10792
PSMA7 -10789
PNP -10751
SP1 -10745
PPAT -10725
VAPA -10722
AKR1C1 -10711
EBP -10707
NUBP2 -10700
NT5C3A -10690
CNDP2 -10685
IDI1 -10669
B4GALT2 -10667
SLC25A17 -10655
GCAT -10649
DARS1 -10628
UGDH -10611
PIAS4 -10602
SEM1 -10597
RXRA -10594
TNFAIP8L1 -10591
CSNK2A2 -10568
HSD17B11 -10564
MED26 -10562
HMGCR -10560
SC5D -10555
RXRB -10546
CPNE3 -10528
CERS5 -10527
PSMA4 -10526
TALDO1 -10514
SLC25A37 -10487
CPOX -10480
GLCE -10458
AMACR -10455
PITPNM1 -10451
GNG2 -10441
PSMB9 -10429
MBOAT2 -10407
PSMB8 -10402
VAC14 -10370
SCO2 -10358
RARS1 -10339
RPL10A -10326
ALDH1L2 -10324
SEC13 -10319
AOC2 -10311
ECI2 -10309
SERINC3 -10307
NDUFB10 -10304
PHKA2 -10299
RPL9 -10276
PLEKHA3 -10270
PSMA1 -10263
PSMD5 -10259
SDHD -10258
ST3GAL4 -10249
PNPLA3 -10234
NDUFS1 -10226
GNPDA1 -10221
ADH5 -10219
TPMT -10202
PARP10 -10199
GPI -10198
PNPLA6 -10196
MMADHC -10186
MED14 -10151
NT5M -10143
NRF1 -10142
GLRX5 -10136
GLUD1 -10131
PTGES3 -10118
DDAH2 -10117
SCLY -10098
NEU1 -10094
GUK1 -10093
EP300 -10088
IMPA2 -10083
GPAT4 -10070
RPS13 -10067
CSNK1G2 -10039
SORD -10037
POM121C -10022
LTA4H -10015
RPL26L1 -10003
DCTD -9991
UBIAD1 -9988
RPS25 -9987
RPL34 -9972
GLS -9971
CES1 -9967
MTMR9 -9965
RPL37A -9962
SEH1L -9948
RPL12 -9944
SLC3A2 -9934
PRKAR2B -9891
CS -9888
HADH -9884
RAPGEF3 -9877
GSTP1 -9869
DLD -9868
PPM1K -9867
CSNK2B -9864
SHPK -9861
INPP5E -9846
RPS6 -9840
SLC25A19 -9837
CIAO1 -9835
PIK3CB -9832
ADCY3 -9829
CBR1 -9814
CHKA -9810
PPP2R1A -9808
PSMD1 -9807
PSMC2 -9799
COX20 -9798
AIP -9794
RPS3A -9784
HSP90AB1 -9782
ARF1 -9777
RAB14 -9776
PPP1CC -9756
ARNT -9754
COX6B1 -9736
RPS18 -9734
LIAS -9717
PSMD8 -9715
AOC3 -9714
SLC7A5 -9688
CRLS1 -9677
IMPDH2 -9672
GNAI1 -9665
HSPG2 -9658
CYB5R3 -9652
PDHX -9651
MED9 -9648
STXBP1 -9644
UQCR10 -9639
SLC5A6 -9633
AMD1 -9632
AIMP1 -9617
MTHFD2 -9604
CA5B -9600
RPL17 -9599
NME4 -9564
MED25 -9560
MCAT -9546
ACBD5 -9544
ELOVL5 -9541
SMPD4 -9525
IDH3A -9507
PAICS -9504
HSD17B12 -9498
ALDH18A1 -9494
AZIN1 -9487
POM121 -9486
MED15 -9481
TNFAIP8 -9479
PLEKHA5 -9438
MIGA2 -9434
HS6ST1 -9428
RPL36 -9425
RPS9 -9422
GDPD3 -9421
MMUT -9414
ADA -9413
MED21 -9408
RPL26 -9404
CYC1 -9403
CBR4 -9399
GSTO1 -9389
RPL31 -9388
NDUFA8 -9381
NDUFAF4 -9367
AOX1 -9364
RPS15A -9361
NOSIP -9353
CHST2 -9348
CDIPT -9346
ATP5PO -9340
MTF1 -9325
GYS1 -9320
ADK -9318
PLA2G6 -9314
TXN2 -9301
IMPDH1 -9283
PPA2 -9280
WASL -9275
BLVRB -9274
PSMB7 -9263
PSME1 -9261
NDUFS3 -9260
SMPD1 -9247
HSD3B7 -9238
SPTLC1 -9236
FDX1 -9232
FAU -9217
FASN -9208
NFS1 -9194
MTHFD1L -9185
PSAT1 -9182
DCTPP1 -9181
TBL1X -9175
SCD5 -9169
MED17 -9167
SERINC1 -9166
DSE -9162
FABP3 -9160
NDUFB9 -9151
RPS4X -9149
ACSL3 -9138
RPL11 -9136
PLPP1 -9131
PLCG1 -9125
PDP2 -9121
GNB1 -9117
ME3 -9113
DNM2 -9093
DDHD1 -9060
NUP153 -9053
GNPDA2 -9042
ARSJ -9019
STK11 -9001
RPS10 -8990
ATP5F1B -8985
GLO1 -8983
PPARA -8971
OSBPL5 -8967
RIMKLB -8917
MLXIPL -8916
IDH1 -8894
MTRR -8887
MRI1 -8865
DIO2 -8856
CERS6 -8854
INSIG1 -8849
NDUFB6 -8840
GCLM -8834
CYP27A1 -8832
RPLP2 -8827
GALK1 -8819
RPL36AL -8817
B4GALT6 -8813
MED19 -8812
NCOR1 -8803
DLST -8794
LMBRD1 -8793
TMEM186 -8787
LIPT1 -8780
PIK3C3 -8770
CA14 -8761
MVD -8757
ATP5MF -8735
DTYMK -8734
PTGS1 -8730
DLAT -8722
FUT3 -8701
GNG12 -8689
PSMD3 -8656
SLC25A15 -8649
UQCRH -8637
TMEM126B -8634
CDK8 -8629
RPL35 -8625
CERK -8612
PYGL -8604
LARS1 -8597
ACOX2 -8594
NDUFS8 -8587
CAD -8582
MED20 -8552
SIN3B -8544
PARP6 -8541
SULT1B1 -8528
UPP1 -8477
RPS12 -8467
RAB5A -8437
MTMR3 -8430
DECR2 -8423
BDH1 -8415
RPL27A -8412
IPPK -8398
PCYT2 -8377
AASDHPPT -8375
CDK19 -8356
RPS3 -8350
NUDT4 -8335
RPS11 -8319
PANK4 -8317
SLC52A2 -8315
GSTM3 -8313
NADK2 -8309
TGS1 -8307
PRKD2 -8306
INPPL1 -8304
NUDT10 -8298
PRKAB2 -8295
PTGS2 -8289
SAMD8 -8285
MTHFR -8261
OSBPL2 -8247
AKR1A1 -8246
ENTPD7 -8245
BCAT1 -8237
ITPR2 -8235
PSMD9 -8231
RPS19 -8226
SPTLC2 -8224
GCLC -8222
CRAT -8218
PFKM -8200
HSD17B7 -8199
ISCA1 -8179
AGPAT2 -8177
SBF2 -8171
PSMD6 -8169
COX18 -8166
RPL8 -8164
AKR7A2 -8153
CPNE1 -8148
SACM1L -8144
PSMF1 -8140
LRPPRC -8122
ARSI -8120
PIP5K1C -8116
FOLH1 -8114
TCN2 -8089
GNA11 -8084
NUP43 -8078
TXN -8043
SMPD2 -8035
FUT5 -8025
RPS15 -8015
CBR3 -8011
ADCY9 -7996
SRD5A1 -7985
COX7B -7984
CARNMT1 -7965
MED31 -7959
NUP58 -7953
MBOAT1 -7952
RAE1 -7937
CERS2 -7919
CERS4 -7910
PLD2 -7901
SULT4A1 -7885
GPS2 -7880
PI4K2A -7860
ADIPOR2 -7847
NDUFA10 -7818
CCNC -7805
COX8A -7804
ALDH6A1 -7801
NAPRT -7793
PGD -7778
SLC35B3 -7774
NDUFC1 -7758
MTHFD1 -7754
ABCA1 -7731
PSMC4 -7727
EPM2A -7722
SRM -7720
CMPK1 -7710
MORC2 -7689
ST3GAL3 -7671
ADSL -7668
NDUFB11 -7657
PSMC6 -7633
CRYM -7625
PPM1L -7611
SBF1 -7574
RPL18A -7530
MVK -7521
SCD -7520
DDAH1 -7517
SLC37A4 -7515
INPP4A -7501
SYNJ1 -7491
PSMB5 -7489
PTEN -7485
PLCB3 -7477
NUP93 -7470
RPL6 -7455
GNB4 -7431
ETNK1 -7425
PSMD10 -7419
NDUFV2 -7415
RPL13A -7403
MED13L -7398
RPL3 -7375
HPSE -7362
UBA52 -7355
PSMD2 -7349
HMBS -7345
MAT2B -7340
NDUFV3 -7326
G6PD -7317
GCSH -7307
APOA5 -7301
SDC2 -7298
NCOA2 -7246
THRAP3 -7228
GSTA4 -7226
AKR1C2 -7221
HS6ST3 -7220
FAH -7209
RPL18 -7207
MLX -7206
PDPR -7180
MCEE -7178
PNPLA2 -7169
PDK3 -7147
RPL39L -7141
ENPP1 -7129
NDUFA5 -7125
UCK1 -7123
NMRAL1 -7112
MPC1 -7093
PLA2G15 -7084
BCAT2 -7079
PSMB6 -7067
COX5B -7061
OSBPL8 -7051
NQO2 -7043
SLC25A1 -7037
PIK3R2 -7036
LSS -7024
PTPMT1 -7015
ELOVL4 -7002
PLCG2 -6994
CERT1 -6973
SEPSECS -6972
ATP5MG -6969
ATP5PF -6964
ERCC2 -6960
COQ9 -6952
XDH -6950
NDUFS5 -6917
RPL14 -6909
DCN -6901
DCXR -6892
CD320 -6883
UST -6865
SUCLG2 -6856
ECSIT -6851
NUP214 -6849
NDUFS6 -6845
SELENOI -6841
RPL21 -6840
SLC19A2 -6821
ISCU -6816
FAHD1 -6804
RPS5 -6800
ALDOC -6796
INPP5F -6783
MED29 -6778
PRSS1 -6740
NDUFA1 -6731
CYP2E1 -6728
GRHPR -6724
PSMD7 -6706
RPL39 -6675
RPL7A -6670
SRR -6666
PITPNM2 -6665
IP6K1 -6659
PLIN3 -6647
PSMB1 -6644
ESD -6639
SGPL1 -6634
B4GALT3 -6624
SLC2A3 -6613
GPC6 -6597
MTMR2 -6596
RPE -6594
MAT1A -6593
PLIN1 -6587
KCNJ11 -6581
ACOX3 -6527
CTRB2 -6513
OAZ1 -6494
PRKAR2A -6478
CPT1B -6448
RANBP2 -6437
NFYB -6415
NUP62 -6390
THEM5 -6389
PPP1CB -6339
HSD17B2 -6331
LPCAT2 -6322
PLEKHA1 -6310
RPS8 -6290
RPL28 -6287
NDC1 -6277
PEMT -6269
LGMN -6267
LCLAT1 -6241
ATP5ME -6219
TRMT112 -6214
GGPS1 -6196
KYAT1 -6188
NEU4 -6168
FAAH -6156
FDX2 -6143
UQCR11 -6139
PSMA3 -6131
GNAQ -6114
ALOXE3 -6096
NDUFAF6 -6086
PIK3C2A -6065
UBB -6063
ISYNA1 -6044
RPL22 -6014
COMT -5996
CDS1 -5995
CYSLTR2 -5971
IMPA1 -5965
GDE1 -5942
ACLY -5936
PPA1 -5925
VAMP2 -5911
COX7A2L -5894
SLC25A32 -5893
COQ7 -5876
PIK3CA -5872
NDUFV1 -5849
CIAO2B -5836
MTMR6 -5829
OGDH -5828
HMGCL -5744
PSMD13 -5738
COX14 -5734
APIP -5707
BDH2 -5698
GNB3 -5686
SLC37A1 -5651
MED6 -5637
NME2 -5630
GLUD2 -5626
PGS1 -5625
NME3 -5620
RAN -5614
NDUFC2 -5613
NDUFAF2 -5595
MTMR14 -5593
MPC2 -5588
BSG -5577
CLOCK -5573
ACER2 -5560
MED18 -5533
PFKL -5531
NDST2 -5479
GDPD5 -5476
INPP5A -5475
AK6 -5474
ACO2 -5458
RPL32 -5445
PDK1 -5433
MTMR7 -5430
SULT1A4 -5429
FAR1 -5376
RPS20 -5374
ACAA1 -5366
MTMR4 -5347
PANK1 -5342
PYCR1 -5340
RFK -5316
MIGA1 -5290
PTDSS1 -5236
PANK3 -5181
HACD2 -5172
VKORC1 -5165
AAAS -5143
COX16 -5140
PDSS2 -5095
LDHA -5075
TMEM86B -5072
ACAD10 -5070
OAZ3 -5067
AFMID -5054
IPMK -5032
PRPS1 -5022
RPL37 -5004
RPL41 -4994
RPL24 -4966
MTM1 -4959
NUDT19 -4957
ITPK1 -4951
ACOT4 -4927
SPR -4909
CA3 -4905
RPL29 -4883
NDUFA3 -4876
ARNTL -4853
AMPD2 -4847
RPL36A -4846
EPHX2 -4817
B3GNT2 -4815
AGXT -4814
OSBPL9 -4812
NDUFA13 -4788
B4GALT4 -4766
SUMO2 -4763
HYKK -4750
GMPS -4747
MPST -4729
PI4K2B -4728
PHOSPHO1 -4713
ENO2 -4701
CYP24A1 -4695
IDH3B -4657
SLC26A2 -4652
SULT2B1 -4644
SLC6A12 -4591
PSME2 -4577
FBP2 -4574
CHST6 -4566
ABO -4557
NDUFB7 -4549
NAT8L -4538
BCKDK -4506
PTGIS -4445
ALOX5 -4437
B3GAT2 -4428
B3GNT4 -4422
PLCH1 -4411
ENO3 -4408
ABHD4 -4407
GGT5 -4398
GLA -4360
NUDT7 -4339
PSMA2 -4323
SMOX -4315
SULT1A3 -4309
SGPP2 -4306
SGMS1 -4289
TBL1XR1 -4277
MED27 -4245
GPC2 -4225
OCRL -4220
SLC19A3 -4219
RPL30 -4218
RPS16 -4149
GNAI2 -4144
RPL10 -4126
ATP5PD -4106
HTD2 -4093
DBT -4084
ATP5MC2 -4076
CHAC2 -4074
AHRR -4026
AKR1B15 -4023
ETFA -4021
ACSM3 -3992
MARCKS -3981
GSTM5 -3965
FDPS -3939
SLC52A1 -3936
GPAT2 -3896
STARD4 -3867
ADI1 -3862
PSMC1 -3828
DCT -3818
CYP8B1 -3802
DECR1 -3790
B3GALT1 -3776
MTHFD2L -3757
LYPLA1 -3753
RPL13 -3746
NDUFAF5 -3737
LYRM4 -3723
PIP4K2B -3666
CERS3 -3663
MAOA -3655
NUDT9 -3653
FABP6 -3638
CTPS1 -3637
DGAT1 -3633
PDHB -3628
PSMB2 -3623
CTRB1 -3600
NFYC -3596
PSMA6 -3583
RPL7 -3582
MAPKAPK2 -3571
ASAH1 -3546
SLC51A -3537
PRKAA2 -3530
HAL -3519
NDUFB5 -3492
CSAD -3474
HS3ST6 -3471
TRIB3 -3462
SPTSSA -3422
STARD3 -3395
PEX11A -3385
GPAT3 -3380
PPP2CA -3355
BAAT -3343
PLEKHA4 -3293
CTH -3291
NR1H2 -3290
CYP2B6 -3280
LPCAT1 -3253
GNPAT -3252
NSDHL -3240
SGPP1 -3226
RPS21 -3225
ZDHHC21 -3192
PHKG2 -3170
CACNB2 -3118
CHST3 -3075
ARSK -3032
AS3MT -2996
IP6K2 -2932
ACY3 -2881
RETSAT -2875
SLC25A28 -2863
HIBCH -2855
CHPT1 -2852
CKM -2843
GDA -2806
RPS26 -2804
CIAPIN1 -2795
GNG5 -2781
CEPT1 -2758
AKR7A3 -2749
MGST1 -2739
CES3 -2737
CYP1A2 -2731
KYNU -2679
CHST7 -2576
UMPS -2534
RUFY1 -2514
B4GALNT2 -2497
LIPT2 -2437
GSTT2 -2395
SERINC4 -2339
IARS1 -2337
PNPLA4 -2323
INPP5K -2299
NAT1 -2296
GNG10 -2270
VNN1 -2243
CYCS -2193
AASS -2179
CDA -2171
GPHN -2083
CD38 -2057
RAP1A -2032
NUDT15 -1982
VCAN -1981
DHTKD1 -1925
RPIA -1922
BPHL -1917
PLCD4 -1902
SLCO1A2 -1887
PIK3R5 -1878
AKT1 -1843
PTS -1838
BLVRA -1831
COX4I1 -1824
GCK -1812
UGCG -1770
HNMT -1751
COX6A1 -1717
SLC36A4 -1699
ATP5F1E -1634
CES2 -1626
RPLP0 -1594
MARS1 -1565
MT-ND2 -1543
RPL35A -1535
PPCS -1534
ADH1B -1492
NUDT12 -1464
GNMT -1454
PSMB4 -1449
DHRS7B -1415
NT5C1B -1363
MIOX -1354
PSMC3 -1344
LDHAL6A -1304
ATP5F1D -1303
NCOA6 -1275
RRM2B -1270
CERS1 -1266
ACOT9 -1265
RPS14 -1250
MOGAT3 -1121
CYP19A1 -1094
GLYATL2 -1091
LDLR -1062
CYP2D6 -1043
UQCRB -1033
B3GAT1 -965
AGT -947
HS2ST1 -907
PLCB1 -905
GADL1 -837
RPL15 -826
CSGALNACT1 -787
CD36 -772
CA7 -768
APOA1 -761
MED4 -735
PLB1 -696
RPS29 -684
SLC22A13 -680
CBSL -614
ALDH9A1 -588
BHMT -574
RPL3L -537
SPTSSB -510
HADHB -448
FH -414
GPD1L -411
PFKP -402
ENPP6 -398
IYD -367
HSD17B13 -332
TPH2 -323
SDHB -314
ATP5F1C -301
GOT1 -265
TTR -223
MED16 -218
RORA -170
APOC2 -144
CYP21A2 -98
PARP16 -85
RIDA -78
GPD1 1
UGT1A1 59
MTR 96
PRKG2 100
IDH3G 123
FABP2 132
RHCE 223
CPNE7 227
RNLS 279
RPSA 306
GLTP 308
PLA2G10 315
HPRT1 373
PLCB2 385
MTHFS 400
HYAL3 445
PITPNM3 478
NOS3 492
CSPG5 567
HSD3B2 584
MT-ND4 591
TIAM2 632
RPS27 679
ACSM2A 730
PSMD4 774
MED8 808
DHFR2 815
CIAO3 836
RHD 841
CA6 842
PSMD12 846
PYGM 896
ITPR3 1010
ADIPOR1 1022
AGMAT 1036
SPHK2 1038
ABHD5 1107
PLA1A 1141
HSD3B1 1143
SUCLG1 1158
PGAM2 1211
ACOT7 1215
DUOX2 1229
SLC22A1 1244
APOM 1250
PODXL2 1286
HOGA1 1344
PPIP5K2 1350
AACS 1389
AHCY 1391
EPRS1 1414
GSTO2 1498
PCYT1A 1529
NUP155 1585
ASAH2 1587
RPL38 1610
SULT1A1 1620
PFKFB2 1662
ACOT13 1675
PLA2G4D 1688
MED30 1697
GSTM2 1699
NDST3 1715
NDUFB3 1717
SLC35D1 1734
CACNA1E 1763
ARG1 1771
HEXB 1828
NT5C1A 1839
SLC52A3 1910
AIMP2 1934
HPD 1974
MED23 1981
SLC25A21 2002
CTRC 2010
GPC1 2014
HLCS 2045
FA2H 2058
ACP5 2117
DDO 2124
COQ10A 2125
HIBADH 2154
ACSBG2 2195
FLAD1 2226
ADCY4 2249
GPX2 2284
ISCA2 2319
ADIPOQ 2345
ABCG2 2404
RPS24 2437
NUBP1 2438
ETFDH 2444
PLAAT1 2456
ACADVL 2457
UGT1A7 2463
GNA14 2464
PRXL2B 2519
HACD4 2569
OMD 2629
PLD4 2642
ARV1 2658
NDUFA9 2676
HSD17B10 2691
ENTPD6 2721
PHKG1 2750
CYP3A5 2778
RPS28 2787
ATP5MC3 2830
ALDOB 2831
INPP5J 2845
ECI1 2859
UCP3 2866
NDUFAF1 2954
ENPP3 2959
PCCB 2999
SULT1A2 3004
ABCB11 3015
GCKR 3034
COQ2 3037
PHKA1 3053
FXN 3074
XYLB 3097
SLC22A5 3099
SLC44A1 3105
ALDH1B1 3124
NUP37 3168
CHSY1 3183
SLC23A1 3244
NAXD 3258
PFKFB1 3298
FLVCR1 3311
LPIN3 3318
ARF3 3329
PCK1 3332
ACSL6 3344
LDHB 3352
SUCLA2 3403
PIPOX 3404
CHST5 3453
LIPH 3538
LRAT 3576
NCAN 3613
CYP1A1 3626
ABHD3 3630
PRKD3 3631
ADRA2A 3709
PGAM1 3727
GGT6 3733
NUDT1 3735
SULT2A1 3809
HSD17B1 3858
OLAH 3865
AZIN2 3881
SDS 3895
GLYATL1 3907
COX11 3958
OXCT2 3969
GALT 3998
RPL19 4011
NDUFS2 4054
TPH1 4063
GLDC 4104
SLC25A14 4143
TPO 4159
BCO2 4187
MBOAT7 4194
ETNK2 4224
ALAS1 4260
MED13 4264
MED11 4269
AKR1D1 4289
CYP2W1 4339
NCOA1 4354
IDO2 4356
MT-ND5 4380
ADH6 4381
ALDH3B1 4448
MTARC2 4449
PNPLA7 4476
CYP2J2 4523
AKR7L 4560
PRELP 4569
NNT 4578
ACSM2B 4622
SLC27A1 4648
MED1 4661
PRODH 4746
GBA3 4747
MT-ND6 4775
RPL5 4778
STARD6 4780
TAT 4798
ABCC2 4832
NT5C2 4866
CGA 4884
HYAL1 4893
GNA15 4986
CKMT2 4994
PPP1CA 5028
ADHFE1 5130
PLEKHA8 5132
ITPA 5133
ALB 5179
PLCH2 5186
MTAP 5234
RPS7 5242
MT-ND1 5310
SERPINA6 5315
STARD7 5329
LHB 5342
COX19 5356
AK8 5371
LDHAL6B 5377
CYP39A1 5430
RPS27A 5458
HACD1 5464
ASPA 5504
ALDH3A2 5532
COX6C 5569
ALOX15 5570
HK2 5614
NDUFS7 5632
CH25H 5635
PSMA5 5639
FITM1 5644
ENTPD1 5648
MMACHC 5669
NOSTRIN 5676
CYP3A43 5694
PDSS1 5750
PTGDS 5813
AUH 5820
AHCYL1 5822
PI4KB 5840
PSTK 5857
SLC5A5 5861
CYP7B1 5862
RPL23 5870
HSD11B2 5881
RAPGEF4 5883
FUT6 5917
CYP4V2 5920
NUDT18 6024
NMRK1 6035
PUDP 6037
NDUFA2 6039
COQ3 6055
MT-CYB 6093
HSD17B3 6110
GCDH 6137
GSTM1 6185
KPNB1 6187
PPT2 6201
MINPP1 6208
HSD17B8 6232
HMMR 6234
DGUOK 6246
PNMT 6277
PLA2G4B 6302
SRD5A3 6303
SEC23A 6313
PIP5K1B 6320
TECR 6340
NUP133 6353
PPP2R1B 6357
CYP4F8 6372
KCNB1 6383
TNFAIP8L3 6395
RRM1 6461
CHD9 6470
NDUFS4 6490
MBTPS2 6505
ACSBG1 6556
CYB5A 6561
RAB4A 6572
KHK 6584
SLC23A2 6587
FUT11 6595
EPHX1 6598
HPGD 6602
GDPD1 6640
ATP5PB 6665
MT-ND3 6673
CROT 6713
SULT1C4 6754
NAXE 6759
SPNS2 6810
SAR1B 6816
NDUFA12 6823
PLPP6 6835
RPL27 6838
HELZ2 6840
AMT 6848
NDUFAF7 6854
STS 6864
CHAT 6879
ADO 6880
SLC25A11 6886
FDXR 6900
ME1 6924
MAOB 6937
VNN2 6946
PAPSS2 6950
FTCD 6958
UCK2 6962
ACADS 6963
DEGS1 7015
AKAP5 7033
DUOX1 7039
RPS23 7043
ITPKB 7056
SLCO1B3 7074
CARNS1 7093
ALOX12 7114
TPST1 7117
PSMC5 7127
ACOT1 7130
HYAL2 7132
SLC26A1 7143
CD44 7147
ORMDL3 7176
MMS19 7192
L2HGDH 7195
N6AMT1 7202
ACSL4 7214
PGLS 7215
SHMT2 7230
NAMPT 7237
ELOVL7 7239
STARD5 7241
SPTLC3 7252
FAM120B 7331
ACOX1 7364
OSBPL1A 7402
SMPD3 7428
RPS27L 7433
BCHE 7441
DHODH 7463
UGT3A2 7487
KMO 7493
FAR2 7519
OXCT1 7529
PIP5K1A 7531
CYP46A1 7556
KCNG2 7577
PIK3C2B 7613
ENTPD8 7633
UPB1 7642
SYNJ2 7650
LPIN2 7664
B4GAT1 7706
PANK2 7716
ACBD7 7761
INSIG2 7763
NAALAD2 7771
GPC5 7776
ACOXL 7809
PSMD11 7823
ACOT8 7826
MGST3 7851
TYMS 7855
NMNAT3 7873
CPT1A 7875
INPP4B 7902
NUP85 7952
GPX1 7965
ABCC8 8000
PSMB3 8008
PECR 8062
ATP5F1A 8101
SURF1 8106
NEU2 8108
MTARC1 8116
COQ6 8130
MAN2B1 8138
NUBPL 8142
MID1IP1 8149
AOC1 8179
FUT2 8181
NDUFB1 8195
ALDH2 8201
SEPHS2 8206
PIK3CD 8228
NUP42 8240
DBI 8252
HK1 8279
IDS 8281
MMAB 8287
LRP8 8292
TAZ 8321
CYP2S1 8329
PIP4K2A 8339
TACO1 8342
SLC9A1 8344
MT-CO3 8348
AK7 8350
PRKACA 8353
CACNA1A 8359
G0S2 8383
MCCC2 8387
GNGT2 8394
TTPA 8445
GPT2 8468
NDUFB8 8470
PIK3CG 8479
ACADSB 8489
PLCD1 8517
MT-ATP6 8523
PIP4K2C 8528
SLC25A44 8542
BCKDHA 8561
SEC24C 8571
EHHADH 8583
LIPE 8585
B3GNT3 8587
D2HGDH 8631
ACADL 8641
GAPDH 8647
NUDT13 8681
SLC25A20 8688
UQCRC1 8691
SLC27A5 8702
PRKAR1A 8703
MT-CO2 8706
PRKAR1B 8711
PGP 8716
COX5A 8723
HS3ST5 8730
TK1 8743
NDST1 8748
ESYT1 8750
HAAO 8791
ABCB7 8795
GPD2 8797
NADK 8810
ALOX12B 8832
CYP26A1 8844
PHYH 8848
PLA2G12A 8863
TPR 8864
SEC24A 8874
SREBF1 8900
GNAS 8902
SLC44A5 8912
CYP26C1 8929
PRKACB 8952
CYP2U1 8956
GPT 8968
DPYD 8973
NDUFA7 8975
NDUFB4 8991
LRP2 9002
TDO2 9017
PMVK 9034
PPOX 9053
PTGES2 9090
ENPP2 9094
UCKL1 9101
GLP1R 9108
RPLP1 9129
SLC19A1 9163
MT-CO1 9170
ST3GAL2 9180
GGT1 9189
GCH1 9196
SLC25A16 9212
BPNT2 9231
NDUFA4 9235
SLC51B 9295
MECR 9299
NHLRC1 9313
TIMMDC1 9314
AK9 9326
MED7 9335
ASRGL1 9339
NDOR1 9349
PGK1 9362
GRHL1 9380
ABCD1 9390
MOCS3 9397
APRT 9400
DERA 9406
DMGDH 9418
TM7SF2 9426
HACD3 9436
SDHC 9448
GPAM 9450
COX15 9456
GLS2 9469
CPT2 9478
GMPR2 9495
MED12 9496
MT-ATP8 9507
GGT7 9516
ABCC5 9531
GUSB 9533
SLC25A12 9539
INMT 9547
CYP2R1 9551
CA13 9554
GSTT2B 9562
COX7C 9586
PKM 9594
PPT1 9608
CYP27B1 9614
TPI1 9622
PLD3 9634
PSMB10 9640
MLYCD 9643
HSD17B14 9656
BST1 9658
PIK3R4 9714
ACBD6 9721
GGCT 9734
PIK3R3 9757
PLCE1 9777
SULT1C2 9783
ESYT3 9824
ACSS1 9826
SIN3A 9839
ARSD 9848
HACL1 9849
NMNAT1 9856
PYCR2 9868
LPGAT1 9892
NDUFA11 9910
KCNS3 9914
CHAC1 9936
CA2 9943
SLC44A3 9949
SGMS2 9957
GNB5 9967
PRKAG2 9986
DBH 10003
INPP1 10008
MTMR10 10042
ABCB1 10043
UROD 10050
ACHE 10051
TST 10060
TNFRSF21 10070
SLC35B2 10076
PLA2G4C 10084
BRIP1 10102
PLCD3 10108
BPNT1 10110
HAGH 10117
PRKD1 10128
NT5C 10139
SHMT1 10144
FUT1 10146
COQ5 10199
NUDT3 10200
AGPS 10203
CHSY3 10205
DNPH1 10208
EXT1 10217
GYG2 10220
QARS1 10237
FIG4 10238
DHCR24 10244
ACSL5 10249
GLB1 10265
PIK3R1 10272
NDUFAF3 10278
ENTPD5 10279
FITM2 10305
SCAP 10310
PDZD11 10315
ADPGK 10332
UQCRQ 10347
B3GALT4 10374
PAOX 10376
UGT8 10391
ELOVL2 10416
GNG7 10417
NUP107 10420
VDAC1 10424
ACSF3 10465
PFAS 10473
PHGDH 10484
ACAA2 10499
PLAAT4 10513
KYAT3 10519
PCBD1 10545
PPARGC1A 10547
MTMR1 10551
SLC25A27 10583
MDH1 10586
GSTM4 10588
HDAC3 10603
PI4KA 10606
SLC25A10 10638
SLC27A2 10639
TMLHE 10663
NADSYN1 10664
B4GALT7 10665
AK2 10671
PPP1R3C 10676
XYLT2 10677
BCKDHB 10678
RBP4 10694
VAPB 10695
ALDH7A1 10696
HADHA 10699
LBR 10720
GYG1 10732
PXMP2 10733
SLC35D2 10740
PC 10745
AADAT 10775
MOCS2 10814
ALDH1L1 10829
CUBN 10836
ENO1 10845
SARS1 10851
ATP5MC1 10858
FHL2 10869
GSTZ1 10880
SLC6A11 10888
GLB1L 10890
PTDSS2 10901
NR1H3 10902
ORMDL2 10912
POLD1 10933
CHP1 10937
TKFC 10948
GBA2 10956
COASY 10958
PNPO 10969
DMAC2L 10970
ABCD4 10981
PSAP 11002
CTSA 11004
CBS 11010
OAT 11026
PDK4 11037
PLEKHA6 11040
ACACB 11044
FPGS 11059
CKMT1A 11061
PHKB 11079
GLYCTK 11105
OSBPL7 11111
CHST12 11114
EXT2 11126
HSD11B1 11127
SNAP25 11174
ACBD4 11189
RBKS 11190
GNS 11202
PTGR2 11203
CHST9 11213
ACOT2 11232
CKB 11236
ALDH4A1 11249
TPK1 11252
AMDHD1 11258
ADCY5 11263
GOT2 11276
CHST13 11280
EEFSEC 11287
GPC4 11293
FABP5 11308
CHKB 11309
SECISBP2 11310
GAMT 11313
GSS 11321
TK2 11326
MED28 11330
GMPR 11346
G6PC3 11373
GM2A 11396
STARD3NL 11407
OCA2 11415
LRP1 11416
RBP1 11422
PON2 11425
MOCS1 11428
CALM1 11432
ACAD8 11450
CPTP 11453
RPL4 11454
CACNA1C 11460
TBXAS1 11462
QDPR 11463
RPL23A 11464
NDUFB2 11470
RTEL1 11476
PDK2 11480
FECH 11486
B3GALT6 11496
DEGS2 11497
PCK2 11498
HSP90AA1 11500
HS3ST4 11506
ADAL 11518
PSPH 11525
SLC44A2 11526
COA1 11541
NME1 11543
SGSH 11569
LHPP 11573
AGL 11583
PCCA 11587
ALAD 11590
ACSF2 11593
AK1 11610
CYB5B 11613
ASS1 11624
AHR 11635
IDUA 11641
HAS3 11642
OSBPL3 11662
BTD 11665
ACACA 11690
THTPA 11712
MED22 11746
SDSL 11753
PLCB4 11757
SCP2 11786
ACAD11 11789
GALC 11814
OPLAH 11818
ARSA 11846
PDP1 11848
SLC46A1 11850
SUMF2 11856
ELOVL6 11859
B4GALNT1 11876
B3GAT3 11887
SLC16A3 11894
PLPP2 11898
SARDH 11900
VDR 11901
PSME3 11914
ACADM 11919
SUOX 11922
SLC27A3 11927
UCP2 11933
SUMF1 11955
PARP14 11957
MED24 11962
PPCDC 11964
NAGS 11990
UROS 11992
ADCY1 12037
GATM 12050
ABHD14B 12055
BGN 12056
SAMHD1 12072
SMARCD3 12081
B3GNT7 12088
MAN2C1 12108
AANAT 12113
ACOT11 12117
GBA 12136
CACNA2D2 12149
PGM1 12152
FADS1 12153
APOE 12161
MAN2B2 12178
BCAN 12182
B3GALT5 12188
ARSB 12189
NPAS2 12202
ACY1 12204
CHST11 12206
IVD 12224
CYP26B1 12231
CHDH 12238
CHPF2 12240
MBTPS1 12255
NAGLU 12266
ACER3 12270
NCOR2 12278
MGST2 12293
ST3GAL1 12302
UGP2 12306
PCTP 12318
MCCC1 12328
CHRM3 12331
SDC1 12333
SLC25A13 12339
PARP9 12342
ADCY6 12352
CACNA1D 12354
CHST14 12371
OAZ2 12408
LPCAT3 12409
SLC2A1 12416
AGK 12419
SDC4 12425
HSD17B4 12429
NUDT5 12436
DUT 12439
PTGR1 12440
AGPAT1 12443
INPP5B 12450
B3GALNT1 12454
PARP8 12457
ACP6 12466
PRKCA 12469
NUP205 12472
CA12 12500
SDC3 12504
SLC6A8 12520
RRM2 12522
OSBPL10 12525
HEXA 12529
BHMT2 12554
PLA2R1 12556
ACAD9 12560
CSPG4 12562
AKR1B1 12565
THEM4 12573
HS6ST2 12574
ESYT2 12584
PLPP3 12593
INPP5D 12597
CDS2 12598
NQO1 12600
ABCC3 12602
ASL 12604
PLBD1 12610
ARSG 12611
GNG4 12612
CHST1 12618
AGRN 12621
GSTK1 12626
GLUL 12634
GAA 12643
TYMP 12665
PTPN13 12725
PPIP5K1 12730
FADS2 12741
PHYKPL 12753
NUDT16 12754
CAV1 12757
DHFR 12771
B4GALT5 12775
AK4 12790
ABCB4 12812
ARNT2 12818
PIK3R6 12819
MGLL 12829
PLIN2 12830
PFKFB4 12835
RIMKLA 12851
PARP4 12860
PFKFB3 12862
NNMT 12863
CYP11A1 12868
PLD1 12869
MOCOS 12870
GALE 12879
RGL1 12886
MAT2A 12887
GBE1 12893
ACSS3 12898
PPARG 12902
GLRX 12909
NT5E 12923
HILPDA 12926
SLC37A2 12931
AMPD3 12935
NMNAT2 12944
NUP210 12959
CEMIP 12965
LRP10 12978
PLAAT3 12981
CYGB 12991
GCHFR 12997
SERINC2 13004
ANGPTL4 13006
CHST15 13009


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.8         
##  [49] XML_3.99-0.9           sass_0.4.0             dbplyr_2.1.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.2            later_1.3.0           
##  [58] AnnotationDbi_1.54.1   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.0            cachem_1.0.6           cli_3.2.0             
##  [64] generics_0.1.2         RSQLite_2.2.10         broom_0.7.12          
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.37             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.32.0        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.0         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.70.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] desc_1.4.1             lattice_0.20-45        Matrix_1.4-1          
##  [88] vctrs_0.3.8            pillar_1.7.0           lifecycle_1.0.1       
##  [91] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [94] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [97] KernSmooth_2.23-20     gridExtra_2.3          assertthat_0.2.1      
## [100] rprojroot_2.0.2        withr_2.5.0            GenomeInfoDbData_1.2.6
## [103] hms_1.1.1              grid_4.2.0             rmarkdown_2.13        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report