date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA  0.7345726
## 7SK       -2.7733284
## A1BG       0.2830631
## A1BG-AS1  -4.1963792
## A1CF      -0.8548135
## A2M       10.9455668
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 24
num_genes_in_profile 27278
duplicated_genes_present 0
num_profile_genes_in_sets 2760
num_profile_genes_not_in_sets 24518

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:
Gene sets metrics
Gene sets metrics
num_genesets 24
num_genesets_excluded 0
num_genesets_included 24

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 24 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Mitochondrial translation 96 6.18e-20 0.5390 7.42e-19
Stabilization of p53 53 2.52e-10 0.5020 2.01e-09
Mitochondrial protein import 64 7.16e-08 0.3890 2.45e-07
Diseases of carbohydrate metabolism 31 2.69e-04 0.3780 5.86e-04
Reduction of cytosolic Ca++ levels 12 2.90e-02 0.3640 4.64e-02
Respiratory electron transport 103 2.48e-09 0.3400 1.19e-08
Signaling by the B Cell Receptor (BCR) 106 6.14e-09 0.3270 2.46e-08
Complex I biogenesis 57 4.65e-05 0.3120 1.24e-04
Mitophagy 28 6.48e-03 0.2970 1.11e-02
Mucopolysaccharidoses 11 1.44e-01 0.2540 1.92e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 53 2.35e-03 0.2410 4.70e-03
Resolution of D-Loop Structures 33 3.59e-02 0.2110 5.39e-02
Metabolism of amino acids and derivatives 344 4.39e-10 0.1950 2.63e-09
Mitochondrial iron-sulfur cluster biogenesis 13 2.35e-01 0.1900 2.96e-01
Cellular response to starvation 150 2.01e-04 0.1760 4.81e-04
Metabolism 1909 7.03e-36 0.1710 1.69e-34
PTEN Regulation 140 3.67e-03 0.1420 6.78e-03
Nervous system development 527 1.48e-07 0.1330 4.45e-07
Mitochondrial biogenesis 91 1.01e-01 0.0993 1.43e-01
Nucleotide biosynthesis 12 6.93e-01 0.0659 7.92e-01
Receptor Mediated Mitophagy 11 7.98e-01 0.0445 8.20e-01
Oxidative Stress Induced Senescence 83 5.13e-01 -0.0415 6.16e-01
Gene Silencing by RNA 98 7.59e-01 0.0179 8.20e-01
Phospholipid metabolism 193 8.20e-01 -0.0095 8.20e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Mitochondrial translation 96 6.18e-20 0.5390 7.42e-19
Stabilization of p53 53 2.52e-10 0.5020 2.01e-09
Mitochondrial protein import 64 7.16e-08 0.3890 2.45e-07
Diseases of carbohydrate metabolism 31 2.69e-04 0.3780 5.86e-04
Reduction of cytosolic Ca++ levels 12 2.90e-02 0.3640 4.64e-02
Respiratory electron transport 103 2.48e-09 0.3400 1.19e-08
Signaling by the B Cell Receptor (BCR) 106 6.14e-09 0.3270 2.46e-08
Complex I biogenesis 57 4.65e-05 0.3120 1.24e-04
Mitophagy 28 6.48e-03 0.2970 1.11e-02
Mucopolysaccharidoses 11 1.44e-01 0.2540 1.92e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 53 2.35e-03 0.2410 4.70e-03
Resolution of D-Loop Structures 33 3.59e-02 0.2110 5.39e-02
Metabolism of amino acids and derivatives 344 4.39e-10 0.1950 2.63e-09
Mitochondrial iron-sulfur cluster biogenesis 13 2.35e-01 0.1900 2.96e-01
Cellular response to starvation 150 2.01e-04 0.1760 4.81e-04
Metabolism 1909 7.03e-36 0.1710 1.69e-34
PTEN Regulation 140 3.67e-03 0.1420 6.78e-03
Nervous system development 527 1.48e-07 0.1330 4.45e-07
Mitochondrial biogenesis 91 1.01e-01 0.0993 1.43e-01
Nucleotide biosynthesis 12 6.93e-01 0.0659 7.92e-01
Receptor Mediated Mitophagy 11 7.98e-01 0.0445 8.20e-01
Oxidative Stress Induced Senescence 83 5.13e-01 -0.0415 6.16e-01
Gene Silencing by RNA 98 7.59e-01 0.0179 8.20e-01
Phospholipid metabolism 193 8.20e-01 -0.0095 8.20e-01


Detailed Gene set reports



Mitochondrial translation

Mitochondrial translation
10
set Mitochondrial translation
setSize 96
pANOVA 6.18e-20
s.dist 0.539
p.adjustANOVA 7.42e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL57 12336
OXA1L 12302
MRPL13 12280
MRPS16 12191
MRPL27 12049
MRPS23 11979
MRPL33 11963
GFM1 11872
ERAL1 11845
MRPL10 11781
MRPS7 11576
GFM2 11575
CHCHD1 11503
MRPS22 11487
MRPL51 11384
MRPL42 11378
MRPL53 11268
MRPL17 11253
MRPL37 11147
MRPS15 11082

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL57 12336
OXA1L 12302
MRPL13 12280
MRPS16 12191
MRPL27 12049
MRPS23 11979
MRPL33 11963
GFM1 11872
ERAL1 11845
MRPL10 11781
MRPS7 11576
GFM2 11575
CHCHD1 11503
MRPS22 11487
MRPL51 11384
MRPL42 11378
MRPL53 11268
MRPL17 11253
MRPL37 11147
MRPS15 11082
MRPS28 11026
MRPS24 11017
MRPL3 10958
MRPL52 10868
AURKAIP1 10719
MRPS36 10716
MRPL11 10677
MRPL35 10421
MRPL50 10372
DAP3 10356
MRPL1 10308
MRPL58 10262
TSFM 10215
MRPS33 10146
MRPL12 10000
MRPL43 9976
MRPL19 9953
MTFMT 9890
MRPL14 9888
MRPL39 9818
MRPL47 9762
MRPS27 9586
MRPS14 9574
MRPL15 9555
MRPS2 9397
MRPS31 9365
MRPL54 9335
MRPL45 9098
MRPL18 9042
MRPL38 8976
MRPS18A 8838
MRPS17 8803
MRPS10 8725
MRPL30 8644
MRPL55 8587
MRPL21 8307
MTRF1L 8128
MRPL9 7923
MRPS18B 7799
MRPL16 7781
MRPL20 7661
MRPL48 7497
MRPL49 7442
MRPL24 7250
MRPS6 7099
MRPS35 6856
MRPS12 6577
MRPS21 6319
MRPL34 6122
MRPL23 5805
MRPL22 4978
MRPL46 4681
MRPL4 2713
MRPS18C 2679
MRPS9 2215
PTCD3 1472
MRPS11 1187
MTIF3 -203
MTIF2 -762
MRPL28 -796
MRPS26 -1102
MRPS34 -2093
MRPL32 -2470
MRPL40 -2614
MRPL44 -2732
MRPS5 -2831
GADD45GIP1 -4356
MRPL41 -4530
TUFM -5404
MRPS30 -6202
MRPL2 -6850
MRRF -7718
MRPS25 -7976
MT-RNR2 -9393
MT-RNR1 -9488
MRPL36 -11868


Stabilization of p53

Stabilization of p53
24
set Stabilization of p53
setSize 53
pANOVA 2.52e-10
s.dist 0.502
p.adjustANOVA 2.01e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
MDM2 11926
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMA5 12432
PSMA6 12089
PSME3 11980
MDM2 11926
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
PSMC3 10692
PSMC5 10666
PSMA1 10273
PSMB6 9989
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
PSMD7 9260
PSMA7 9241
PSMD4 8653
PSMD1 8598
PSMD14 8452
PSMA4 8117
PSMD2 7977
UBC 7520
PSMC2 7229
PSMD9 7167
PHF20 5693
PSME2 3149
SEM1 3082
PSMB7 2916
PSMB10 2792
PSMD6 140
PSME1 -1500
UBA52 -2054
PSME4 -6905
MDM4 -8181
PSMD5 -8988
TP53 -9081
PSMB8 -9809
CHEK2 -10300
PSMB9 -11036
ATM -13463


Mitochondrial protein import

Mitochondrial protein import
9
set Mitochondrial protein import
setSize 64
pANOVA 7.16e-08
s.dist 0.389
p.adjustANOVA 2.45e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5MC1 12573
COX17 12359
VDAC1 12310
CHCHD3 12245
TOMM70 12026
SLC25A6 12007
CHCHD2 11983
TOMM20 11790
CMC2 11709
CHCHD7 11462
GRPEL1 11344
TOMM7 11024
MTX1 10918
COQ2 10825
TIMM10 10497
COA4 10405
HSPA9 10341
TIMM8A 10168
SLC25A4 10162
ATP5F1A 9986

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MC1 12573
COX17 12359
VDAC1 12310
CHCHD3 12245
TOMM70 12026
SLC25A6 12007
CHCHD2 11983
TOMM20 11790
CMC2 11709
CHCHD7 11462
GRPEL1 11344
TOMM7 11024
MTX1 10918
COQ2 10825
TIMM10 10497
COA4 10405
HSPA9 10341
TIMM8A 10168
SLC25A4 10162
ATP5F1A 9986
NDUFB8 9982
TIMM17A 9940
TOMM6 9939
ATP5F1B 9845
DNAJC19 9727
TIMM22 9549
CHCHD4 9482
FXN 9330
TOMM5 9321
CYC1 9271
IDH3G 9230
TIMM8B 8648
LDHD 8489
TIMM13 8131
TIMM23 8061
TIMM10B 7899
COA6 7676
TIMM21 6894
TIMM9 6330
CHCHD5 6094
CHCHD10 5478
CMC4 4901
GRPEL2 4637
TOMM40 4435
PMPCB 4238
TOMM22 2845
SLC25A13 2099
SAMM50 1470
TIMM50 537
HSPD1 -1723
TIMM17B -2485
GFER -5974
HSCB -7371
CS -9622
SLC25A12 -10565
COX19 -10574
PAM16 -11254
PMPCA -11592
MTX2 -11908
TIMM44 -12108
ACO2 -12540
BCS1L -13436
TAZ -13685
PITRM1 -13744


Diseases of carbohydrate metabolism

Diseases of carbohydrate metabolism
3
set Diseases of carbohydrate metabolism
setSize 31
pANOVA 0.000269
s.dist 0.378
p.adjustANOVA 0.000586



Top enriched genes

Top 20 genes
GeneID Gene Rank
GBE1 12368
GAA 11239
GNS 11231
GLB1 11226
RPS27A 11143
GYG1 11054
UBB 10939
RPIA 10850
NAGLU 10710
ARSB 10097
GUSB 10083
G6PC3 10066
NHLRC1 9613
DCXR 9392
TALDO1 9139
GYG2 7634
UBC 7520
SLC37A4 7077
KHK 6967
PPP1R3C 6919

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GBE1 12368
GAA 11239
GNS 11231
GLB1 11226
RPS27A 11143
GYG1 11054
UBB 10939
RPIA 10850
NAGLU 10710
ARSB 10097
GUSB 10083
G6PC3 10066
NHLRC1 9613
DCXR 9392
TALDO1 9139
GYG2 7634
UBC 7520
SLC37A4 7077
KHK 6967
PPP1R3C 6919
SGSH 6097
IDS 2486
GALNS 2365
UBA52 -2054
LCT -5895
ALDOB -7977
HYAL1 -9718
EPM2A -10168
GYS1 -12080
IDUA -12184
HGSNAT -14027


Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels
20
set Reduction of cytosolic Ca++ levels
setSize 12
pANOVA 0.029
s.dist 0.364
p.adjustANOVA 0.0464



Top enriched genes

Top 20 genes
GeneID Gene Rank
CALM1 12384
ATP2A2 11729
SLC8A3 9490
SLC8A1 9371
ATP2A3 9155
ATP2B1 8777
SLC8A2 8579
ATP2B4 6724
SRI 6165
ATP2B2 -8957
ATP2A1 -11823
ATP2B3 -12707

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CALM1 12384
ATP2A2 11729
SLC8A3 9490
SLC8A1 9371
ATP2A3 9155
ATP2B1 8777
SLC8A2 8579
ATP2B4 6724
SRI 6165
ATP2B2 -8957
ATP2A1 -11823
ATP2B3 -12707


Respiratory electron transport

Respiratory electron transport
22
set Respiratory electron transport
setSize 103
pANOVA 2.48e-09
s.dist 0.34
p.adjustANOVA 1.19e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
COA1 12418
COX5A 12414
NDUFB2 12409
UQCRQ 12164
SDHB 12152
CYCS 12143
COX7C 11984
COX8A 11860
NDUFA4 11721
NDUFB5 11704
NDUFS4 11701
SDHC 11556
NDUFC2 11535
NDUFA2 11421
TACO1 11418
ACAD9 11417
UQCRC1 11375
NDUFA12 11230
NDUFAF3 11202
COX16 11162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COA1 12418
COX5A 12414
NDUFB2 12409
UQCRQ 12164
SDHB 12152
CYCS 12143
COX7C 11984
COX8A 11860
NDUFA4 11721
NDUFB5 11704
NDUFS4 11701
SDHC 11556
NDUFC2 11535
NDUFA2 11421
TACO1 11418
ACAD9 11417
UQCRC1 11375
NDUFA12 11230
NDUFAF3 11202
COX16 11162
NDUFA7 11121
COX6C 10869
COX7A2L 10851
NDUFB4 10750
NDUFB9 10707
NDUFA11 10691
NDUFB6 10245
NDUFAF1 10186
COX14 10130
NDUFB8 9982
ETFA 9819
COX7B 9811
NDUFAF2 9779
COX11 9581
UQCR11 9467
UQCRH 9389
CYC1 9271
NDUFB3 8999
NDUFB7 8834
NDUFC1 8792
NDUFS7 8742
NDUFA9 8604
NDUFAB1 8321
COX4I1 8290
UQCRFS1 8179
NDUFB1 7933
COX6A1 7845
SCO2 7484
SDHD 7416
NDUFA1 7219
LRPPRC 7212
NDUFAF7 7058
NDUFB11 7017
TIMMDC1 6861
NDUFS5 6761
NDUFA13 6712
NUBPL 6271
SURF1 5856
UQCR10 5712
ECSIT 5274
NDUFS6 4346
NDUFS3 3752
MT-CO2 3466
MT-CO1 2218
UQCRB 1884
SDHA 1401
NDUFA8 1250
ETFDH 778
NDUFV2 696
NDUFAF4 -130
NDUFAF5 -160
NDUFA5 -387
NDUFS2 -1149
TMEM126B -1954
NDUFV3 -1980
COX6B1 -2140
NDUFS1 -2730
NDUFA6 -3174
COQ10A -3410
COX5B -3541
COQ10B -4036
MT-ND6 -4822
MT-ND5 -4997
UQCRC2 -5023
MT-CO3 -5871
NDUFA3 -5928
COX20 -6582
MT-ND4 -7077
NDUFS8 -7676
SCO1 -7776
NDUFAF6 -8002
MT-CYB -8003
MT-ND1 -8061
MT-ND2 -8787
NDUFB10 -9509
TMEM186 -9598
COX18 -9772
NDUFV1 -9973
COX19 -10574
MT-ND3 -11022
TRAP1 -13125
NDUFA10 -13615
ETFB -14250


Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)
23
set Signaling by the B Cell Receptor (BCR)
setSize 106
pANOVA 6.14e-09
s.dist 0.327
p.adjustANOVA 2.46e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
KRAS 12711
PRKCB 12472
PSMA5 12432
CALM1 12384
CUL1 12341
PSMA6 12089
STIM1 12081
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
FKBP1A 11597
PSMC1 11554
PSMD11 11493
PSMB2 11467
GRB2 11361
RPS27A 11143

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KRAS 12711
PRKCB 12472
PSMA5 12432
CALM1 12384
CUL1 12341
PSMA6 12089
STIM1 12081
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
SKP1 11672
FKBP1A 11597
PSMC1 11554
PSMD11 11493
PSMB2 11467
GRB2 11361
RPS27A 11143
PPIA 11124
PSMB5 11025
AHCYL1 10982
ORAI1 10973
PSMD13 10950
UBB 10939
BCL10 10873
PSMD10 10775
PSMC3 10692
PSMC5 10666
PPP3R1 10616
PIK3R1 10540
PSMA1 10273
PSMB6 9989
NCK1 9987
PSMC6 9977
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
SH3KBP1 9364
PSMD7 9260
PSMA7 9241
LYN 8955
NRAS 8912
FBXW11 8658
PSMD4 8653
SYK 8639
PSMD1 8598
PSMD14 8452
CHUK 8379
NFKBIA 8250
IKBKG 8142
PSMA4 8117
PSMD2 7977
PIK3AP1 7824
RASGRP1 7685
UBC 7520
PSMC2 7229
PSMD9 7167
CD79B 5551
NFATC1 4994
NFKBIE 3367
PSME2 3149
SEM1 3082
PSMB7 2916
CD22 2907
PSMB10 2792
BTRC 2663
PSMD6 140
NFKBIB -717
CD79A -1254
PSME1 -1500
NFATC3 -1574
UBA52 -2054
BLK -2742
MAP3K7 -3053
PPP3CA -3476
REL -4475
ITPR2 -4885
VAV1 -5079
TRPC1 -5142
PPP3CB -6238
PSME4 -6905
BTK -6988
HRAS -7282
RASGRP3 -7573
PTPN6 -7581
PSMD5 -8988
BLNK -9010
PLCG2 -9310
PSMB8 -9809
SOS1 -10165
PSMB9 -11036
RELA -11381
NFKB1 -11411
CARD11 -11567
ORAI2 -12329
PIK3CD -13104
FYN -13113
ITPR3 -13411
ITPR1 -13544
MALT1 -13892
IKBKB -13900
NFATC2 -14261


Complex I biogenesis

Complex I biogenesis
2
set Complex I biogenesis
setSize 57
pANOVA 4.65e-05
s.dist 0.312
p.adjustANOVA 0.000124



Top enriched genes

Top 20 genes
GeneID Gene Rank
COA1 12418
NDUFB2 12409
NDUFB5 11704
NDUFS4 11701
NDUFC2 11535
NDUFA2 11421
ACAD9 11417
NDUFA12 11230
NDUFAF3 11202
NDUFA7 11121
NDUFB4 10750
NDUFB9 10707
NDUFA11 10691
NDUFB6 10245
NDUFAF1 10186
NDUFB8 9982
NDUFAF2 9779
NDUFB3 8999
NDUFB7 8834
NDUFC1 8792

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COA1 12418
NDUFB2 12409
NDUFB5 11704
NDUFS4 11701
NDUFC2 11535
NDUFA2 11421
ACAD9 11417
NDUFA12 11230
NDUFAF3 11202
NDUFA7 11121
NDUFB4 10750
NDUFB9 10707
NDUFA11 10691
NDUFB6 10245
NDUFAF1 10186
NDUFB8 9982
NDUFAF2 9779
NDUFB3 8999
NDUFB7 8834
NDUFC1 8792
NDUFS7 8742
NDUFA9 8604
NDUFAB1 8321
NDUFB1 7933
NDUFA1 7219
NDUFAF7 7058
NDUFB11 7017
TIMMDC1 6861
NDUFS5 6761
NDUFA13 6712
NUBPL 6271
ECSIT 5274
NDUFS6 4346
NDUFS3 3752
NDUFA8 1250
NDUFV2 696
NDUFAF4 -130
NDUFAF5 -160
NDUFA5 -387
NDUFS2 -1149
TMEM126B -1954
NDUFV3 -1980
NDUFS1 -2730
NDUFA6 -3174
MT-ND6 -4822
MT-ND5 -4997
NDUFA3 -5928
MT-ND4 -7077
NDUFS8 -7676
NDUFAF6 -8002
MT-ND1 -8061
MT-ND2 -8787
NDUFB10 -9509
TMEM186 -9598
NDUFV1 -9973
MT-ND3 -11022
NDUFA10 -13615


Mitophagy

Mitophagy
11
set Mitophagy
setSize 28
pANOVA 0.00648
s.dist 0.297
p.adjustANOVA 0.0111



Top enriched genes

Top 20 genes
GeneID Gene Rank
VDAC1 12310
TOMM70 12026
TOMM20 11790
RPS27A 11143
TOMM7 11024
UBB 10939
TOMM6 9939
MFN1 9495
TOMM5 9321
MAP1LC3B 8827
ATG5 8732
PGAM5 8457
CSNK2A1 7686
UBC 7520
FUNDC1 5889
ATG12 4621
TOMM40 4435
TOMM22 2845
CSNK2B 1532
MFN2 605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VDAC1 12310
TOMM70 12026
TOMM20 11790
RPS27A 11143
TOMM7 11024
UBB 10939
TOMM6 9939
MFN1 9495
TOMM5 9321
MAP1LC3B 8827
ATG5 8732
PGAM5 8457
CSNK2A1 7686
UBC 7520
FUNDC1 5889
ATG12 4621
TOMM40 4435
TOMM22 2845
CSNK2B 1532
MFN2 605
PINK1 -1771
UBA52 -2054
MTERF3 -5054
CSNK2A2 -10004
MAP1LC3A -10700
SQSTM1 -12916
SRC -13925
ULK1 -14214


Mucopolysaccharidoses

Mucopolysaccharidoses
12
set Mucopolysaccharidoses
setSize 11
pANOVA 0.144
s.dist 0.254
p.adjustANOVA 0.192



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNS 11231
GLB1 11226
NAGLU 10710
ARSB 10097
GUSB 10083
SGSH 6097
IDS 2486
GALNS 2365
HYAL1 -9718
IDUA -12184
HGSNAT -14027

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNS 11231
GLB1 11226
NAGLU 10710
ARSB 10097
GUSB 10083
SGSH 6097
IDS 2486
GALNS 2365
HYAL1 -9718
IDUA -12184
HGSNAT -14027


Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
18
set Pyruvate metabolism and Citric Acid (TCA) cycle
setSize 53
pANOVA 0.00235
s.dist 0.241
p.adjustANOVA 0.0047



Top enriched genes

Top 20 genes
GeneID Gene Rank
VDAC1 12310
PDP1 12297
SLC16A3 12160
SDHB 12152
FH 11951
SDHC 11556
LDHA 11429
IDH2 11276
SUCLG1 11128
LDHB 11062
L2HGDH 10401
PDHB 10313
SUCLA2 10122
OGDH 10063
GLO1 9893
PDK2 9784
MPC2 9705
SUCLG2 9340
PDHX 9244
IDH3G 9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VDAC1 12310
PDP1 12297
SLC16A3 12160
SDHB 12152
FH 11951
SDHC 11556
LDHA 11429
IDH2 11276
SUCLG1 11128
LDHB 11062
L2HGDH 10401
PDHB 10313
SUCLA2 10122
OGDH 10063
GLO1 9893
PDK2 9784
MPC2 9705
SUCLG2 9340
PDHX 9244
IDH3G 9230
GSTZ1 9116
ME1 8589
PDK4 8337
DLAT 7971
PDK1 7836
SLC16A1 7826
MDH2 7508
SDHD 7416
HAGH 6807
MPC1 5749
BSG 5557
IDH3B 4704
SDHA 1401
LDHAL6A -1561
LDHC -2448
DLD -2805
IDH3A -2920
PDK3 -4995
LDHAL6B -6242
FAHD1 -8168
ME2 -8374
PDP2 -8808
CS -9622
ME3 -9829
PDHA1 -11566
NNT -11690
DLST -11839
ADHFE1 -12130
RXRA -12352
D2HGDH -12407
ACO2 -12540
PDPR -12652
PPARD -14180


Resolution of D-Loop Structures

Resolution of D-Loop Structures
21
set Resolution of D-Loop Structures
setSize 33
pANOVA 0.0359
s.dist 0.211
p.adjustANOVA 0.0539



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD51 12054
EME1 11875
BRCA1 11795
XRCC2 11775
EXO1 11623
RAD51C 11506
RAD51AP1 11341
SPIDR 11057
GEN1 10908
BRCA2 10680
RMI1 10387
RTEL1 10260
BRIP1 9639
XRCC3 8609
RAD51D 8352
RAD51B 7613
RMI2 7033
RBBP8 4797
BARD1 4381
SLX4 1840

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51 12054
EME1 11875
BRCA1 11795
XRCC2 11775
EXO1 11623
RAD51C 11506
RAD51AP1 11341
SPIDR 11057
GEN1 10908
BRCA2 10680
RMI1 10387
RTEL1 10260
BRIP1 9639
XRCC3 8609
RAD51D 8352
RAD51B 7613
RMI2 7033
RBBP8 4797
BARD1 4381
SLX4 1840
TOP3A -635
BLM -3738
RAD50 -5242
KAT5 -7984
MRE11 -8285
DNA2 -9757
NBN -10131
PALB2 -10451
MUS81 -12353
EME2 -12644
SLX1A -13329
ATM -13463
WRN -13994


Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives
6
set Metabolism of amino acids and derivatives
setSize 344
pANOVA 4.39e-10
s.dist 0.195
p.adjustANOVA 2.63e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
SERINC2 12744
RIMKLA 12637
CKB 12468
PSMA5 12432
RPL23A 12415
BHMT2 12376
SLC6A8 12357
OAZ2 12229
PSMA6 12089
RPL39L 12068
GLUL 12030
PSME3 11980
GATM 11904
PSMD12 11895
OAT 11859
AHCY 11832
PSMA3 11818
PSMA2 11784
NNMT 11760
ASS1 11746

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SERINC2 12744
RIMKLA 12637
CKB 12468
PSMA5 12432
RPL23A 12415
BHMT2 12376
SLC6A8 12357
OAZ2 12229
PSMA6 12089
RPL39L 12068
GLUL 12030
PSME3 11980
GATM 11904
PSMD12 11895
OAT 11859
AHCY 11832
PSMA3 11818
PSMA2 11784
NNMT 11760
ASS1 11746
EEFSEC 11745
PSMD3 11738
PSMB3 11727
QDPR 11719
AMD1 11693
PSMC1 11554
GOT1 11520
PSMD11 11493
PSMB2 11467
RPS29 11452
PYCR2 11439
RPS27L 11435
KYAT3 11349
SLC25A10 11325
AIMP2 11323
GOT2 11232
MCCC1 11224
NQO1 11204
RPL4 11190
ALDH9A1 11188
ALDH7A1 11174
RPS27A 11143
GAMT 11098
CKMT1A 11066
PSMB5 11025
ASRGL1 10956
PSMD13 10950
PSMD10 10775
RPS27 10764
PSMC3 10692
PSMC5 10666
DHTKD1 10528
RPS23 10485
GCSH 10475
RPL41 10426
BCKDHA 10420
TST 10370
OAZ1 10369
SLC6A11 10327
PDHB 10313
PSMA1 10273
CHDH 10267
RPSA 10265
AANAT 10237
RPLP1 10204
ASL 10096
OGDH 10063
RPS24 9992
PSMB6 9989
PSMC6 9977
RPL27 9972
PSMF1 9900
RPS7 9899
TMLHE 9886
SDSL 9881
BCKDHB 9796
SARDH 9764
PCBD1 9713
ALDH18A1 9691
PSMB4 9649
PXMP2 9627
PSMB1 9583
GLS2 9516
SHMT1 9492
PSMC4 9483
SLC36A4 9474
RPL35A 9472
PSMD8 9468
RPL15 9329
PSMD7 9260
PDHX 9244
PSMA7 9241
SLC25A15 9198
ADO 9178
GSTZ1 9116
RPL21 9112
NAGS 9110
RPLP0 9040
TXNRD1 8965
TDO2 8951
RPS28 8929
RPL30 8900
PYCR1 8876
RPL39 8797
OCA2 8700
DBH 8687
RPL36AL 8682
PSMD4 8653
PSMD1 8598
IVD 8570
RPL7 8557
SLC44A1 8555
RPS12 8531
PSMD14 8452
RPL5 8413
ALDH6A1 8363
NDUFAB1 8321
RPS8 8313
RPL13A 8240
SERINC3 8199
PSMA4 8117
QARS1 8019
PSMD2 7977
DLAT 7971
RPL19 7936
PSPH 7909
SERINC1 7857
ALDH4A1 7817
ADI1 7802
HSD17B10 7784
SLC25A44 7728
AUH 7716
GLUD1 7688
PAPSS1 7635
PNMT 7446
RPL22 7316
PSTK 7297
RPS26 7266
PSMC2 7229
RPS21 7205
PSMD9 7167
RPS5 7111
RPL23 7085
RPL26L1 7054
SLC5A5 7010
RPL18A 6963
RPS3 6933
RIDA 6884
KARS1 6874
SRM 6728
SARS1 6685
RPS16 6660
RPL3 6633
EPRS1 6632
HPD 6626
DBT 6556
RPS14 6310
RPL10 6263
GLDC 6247
RPL22L1 6160
HIBADH 5933
RPL7A 5755
RPS20 5683
RPS13 5560
DMGDH 5466
TPO 5394
RPS19 5159
HOGA1 5078
RPS3A 5004
RPL26 4984
PAPSS2 4850
CKMT2 4666
APIP 4348
BCKDK 4317
CGA 4307
RPS11 4282
EEF1E1 4229
RPS25 4151
TPH2 3968
MTR 3776
RPL13 3702
CARNMT1 3681
KYAT1 3382
RPL10A 3181
AZIN1 3170
PSME2 3149
SEM1 3082
PSMB7 2916
GCAT 2857
PSMB10 2792
TDH 2616
RPL38 2281
SLC25A13 2099
SLC25A21 2063
ACADSB 1675
NAT8L 1593
HYKK 1548
IDO1 1448
MPST 1330
LIPT2 1192
RPL36A 1011
RPLP2 960
NAALAD2 440
RPL32 418
DCT 367
RPL6 348
SEPHS2 321
HAAO 307
CBSL 216
PSMD6 140
HIBCH 39
AMDHD1 -170
RPL27A -460
PRODH -794
ASPA -839
BHMT -929
PAOX -936
RPL24 -1041
DUOX1 -1385
PSME1 -1500
GCDH -1556
AFMID -1947
TAT -1992
UBA52 -2054
RPL14 -2302
ARG1 -2345
RPL29 -2351
HAL -2608
KMO -2617
ENOPH1 -2775
SDS -2786
DLD -2805
MCCC2 -2979
CDO1 -3302
HNMT -3405
DARS1 -3530
IDO2 -3560
CRYM -3726
DDO -4155
CKM -4173
TXN2 -4298
PHGDH -4742
GRHPR -4756
RPL11 -4818
HGD -4905
SECISBP2 -4909
SMS -5124
RPS15A -5253
RARS1 -5338
PPM1K -5396
MTAP -5609
RPL3L -5663
DIO1 -5818
AGMAT -5860
SRR -5891
RPS9 -5925
FAU -5971
AGXT -6167
AIMP1 -6616
INMT -6708
PSME4 -6905
AZIN2 -6941
GPT -6947
OAZ3 -7199
LIAS -7290
RPS10 -7365
SUOX -7377
RPL35 -7428
IYD -7482
UROC1 -7575
ETHE1 -7637
RPL8 -7687
MRI1 -7692
ACAT1 -8037
GADL1 -8121
SERINC5 -8635
PSMD5 -8988
RPS4X -8997
GNMT -9126
RPL36 -9255
TPH1 -9278
BCAT2 -9313
RPS6 -9318
RPS15 -9442
RPL12 -9556
RPL34 -9603
RPL37 -9709
RIMKLB -9768
PSMB8 -9809
CARNS1 -9990
RPS17 -10017
SLC6A12 -10029
RPL31 -10046
PHYKPL -10432
RPL28 -10480
SLC25A12 -10565
RPS18 -10647
NMRAL1 -10716
RPL9 -10760
FOLH1 -10817
GLUD2 -10826
BCAT1 -10956
PSMB9 -11036
KYNU -11160
PIPOX -11181
CBS -11193
AADAT -11206
DUOX2 -11302
ACAD8 -11307
IARS1 -11325
RPL18 -11409
CTH -11443
GPT2 -11505
PDHA1 -11566
FAH -11748
RPL37A -11759
RPS2 -11806
DLST -11839
RPL17 -11954
SEPSECS -12066
LIPT1 -12156
MAT1A -12202
SCLY -12538
MTRR -12554
MARS1 -12820
FTCD -12823
ODC1 -12824
SMOX -12833
AASS -13137
PSAT1 -13349
AMT -13461
LARS1 -13510
SLC3A2 -13519
GSR -13531
SLC7A5 -13536
CSAD -13757
CPS1 -13843
DIO2 -13889
GLS -14043
ARG2 -14089
ECHS1 -14139
IL4I1 -14275
ASNS -14454
SAT1 -14469


Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis
8
set Mitochondrial iron-sulfur cluster biogenesis
setSize 13
pANOVA 0.235
s.dist 0.19
p.adjustANOVA 0.296



Top enriched genes

Top 20 genes
GeneID Gene Rank
ISCA2 10799
LYRM4 10545
GLRX5 10305
FXN 9330
FDXR 9301
ISCA1 8703
NFS1 3881
FDX1 845
FDX2 -206
HSCB -7371
ISCU -8462
SLC25A28 -11209
SLC25A37 -14266

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ISCA2 10799
LYRM4 10545
GLRX5 10305
FXN 9330
FDXR 9301
ISCA1 8703
NFS1 3881
FDX1 845
FDX2 -206
HSCB -7371
ISCU -8462
SLC25A28 -11209
SLC25A37 -14266


Cellular response to starvation

Cellular response to starvation
1
set Cellular response to starvation
setSize 150
pANOVA 0.000201
s.dist 0.176
p.adjustANOVA 0.000481



Top enriched genes

Top 20 genes
GeneID Gene Rank
RHEB 12630
ATP6V0E2 12594
RPL23A 12415
RPL39L 12068
RRAGA 12012
LAMTOR5 11685
RPS29 11452
RPS27L 11435
SEC13 11424
ATP6V1A 11381
RPL4 11190
RPS27A 11143
ATP6V1D 11065
RRAGD 11053
EIF2S1 10887
RPS27 10764
ATP6V1C1 10702
ATP6V0D1 10649
ATP6V0B 10536
RPS23 10485

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RHEB 12630
ATP6V0E2 12594
RPL23A 12415
RPL39L 12068
RRAGA 12012
LAMTOR5 11685
RPS29 11452
RPS27L 11435
SEC13 11424
ATP6V1A 11381
RPL4 11190
RPS27A 11143
ATP6V1D 11065
RRAGD 11053
EIF2S1 10887
RPS27 10764
ATP6V1C1 10702
ATP6V0D1 10649
ATP6V0B 10536
RPS23 10485
RPL41 10426
RPSA 10265
RPLP1 10204
EIF2AK4 10087
RPS24 9992
RPL27 9972
LAMTOR1 9960
ATP6V0C 9955
RPS7 9899
RPL35A 9472
CEBPB 9459
RPL15 9329
ATP6V1H 9307
RPL21 9112
RPLP0 9040
RPS28 8929
RPL30 8900
RPL39 8797
RPL36AL 8682
RPL7 8557
RPS12 8531
RPL5 8413
RPS8 8313
RPL13A 8240
ITFG2 8187
LAMTOR2 8007
RPL19 7936
ATP6V1C2 7547
RPL22 7316
ATP6V1E2 7313
RPS26 7266
RPS21 7205
RPS5 7111
RPL23 7085
RPL26L1 7054
SESN1 7043
RPL18A 6963
RPS3 6933
LAMTOR3 6791
RPS16 6660
RPL3 6633
MTOR 6555
ATP6V1G1 6390
ATP6V1G2 6315
RPS14 6310
RPL10 6263
RPL22L1 6160
SLC38A9 6124
TRIB3 6085
IMPACT 5862
RPL7A 5755
RPS20 5683
RPS13 5560
RPS19 5159
ATP6V1E1 5055
RPS3A 5004
RPL26 4984
EIF2S2 4969
SH3BP4 4844
ATF3 4387
RPS11 4282
RPS25 4151
RPL13 3702
FNIP2 3390
RPL10A 3181
RPL38 2281
RPTOR 2038
BMT2 1764
RPL36A 1011
RPLP2 960
MIOS 580
RPL32 418
RPL6 348
LAMTOR4 -46
ATP6V0E1 -297
RPL27A -460
RPL24 -1041
UBA52 -2054
RPL14 -2302
RPL29 -2351
EIF2S3 -4483
KPTN -4679
RPL11 -4818
NPRL2 -4849
RPS15A -5253
DDIT3 -5544
RPL3L -5663
RPS9 -5925
FAU -5971
SEH1L -5984
ATP6V1B1 -6677
RPS10 -7365
RPL35 -7428
RPL8 -7687
ATP6V1F -7929
GCN1 -8062
SESN2 -8160
ATF2 -8741
RPS4X -8997
RRAGC -9224
RPL36 -9255
RPS6 -9318
RPS15 -9442
RPL12 -9556
RPL34 -9603
RPL37 -9709
RPS17 -10017
RPL31 -10046
RPL28 -10480
RPS18 -10647
CEBPG -10661
RPL9 -10760
ATF4 -10995
WDR24 -11011
SZT2 -11050
RRAGB -11312
RPL18 -11409
ATP6V0D2 -11555
RPL37A -11759
RPS2 -11806
RPL17 -11954
DEPDC5 -12475
MLST8 -12519
ATP6V1B2 -12886
FNIP1 -13129
NPRL3 -13735
WDR59 -13785
FLCN -14175
TCIRG1 -14222
ASNS -14454


Metabolism

Metabolism
5
set Metabolism
setSize 1909
pANOVA 7.03e-36
s.dist 0.171
p.adjustANOVA 1.69e-34



Top enriched genes

Top 20 genes
GeneID Gene Rank
ANGPTL4 12747
SERINC2 12744
HILPDA 12743
PLAAT3 12737
PPARG 12736
CYGB 12730
PLIN2 12693
RRM2 12689
CHST15 12675
DHFR 12674
PFKFB4 12669
SLC2A1 12668
DHCR24 12666
PIK3R6 12650
INSIG1 12643
RIMKLA 12637
HSP90AA1 12629
GLRX 12622
GALE 12617
HSD17B4 12592

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANGPTL4 12747
SERINC2 12744
HILPDA 12743
PLAAT3 12737
PPARG 12736
CYGB 12730
PLIN2 12693
RRM2 12689
CHST15 12675
DHFR 12674
PFKFB4 12669
SLC2A1 12668
DHCR24 12666
PIK3R6 12650
INSIG1 12643
RIMKLA 12637
HSP90AA1 12629
GLRX 12622
GALE 12617
HSD17B4 12592
PLD1 12574
ATP5MC1 12573
GPC4 12569
UCP2 12560
NUP210 12555
FADS1 12545
AK4 12535
FADS2 12532
UGP2 12518
NUP205 12488
GCHFR 12481
PCCB 12470
CKB 12468
MGST2 12441
PGM1 12439
PSMA5 12432
APRT 12430
NME1 12422
TBXAS1 12419
COA1 12418
RPL23A 12415
COX5A 12414
NDUFB2 12409
GGCT 12403
TYMS 12399
CALM1 12384
MOCOS 12383
NMNAT2 12380
BHMT2 12376
LPCAT3 12373
HEXA 12372
GBE1 12368
AKR1B1 12367
SLC6A8 12357
SDC4 12347
NAMPT 12340
ACOT7 12339
PGK1 12335
PPCDC 12334
RBP4 12329
CHST14 12327
UGCG 12326
HMMR 12312
VDAC1 12310
B3GALNT1 12306
PDP1 12297
SLC37A2 12288
PLAAT4 12266
MDH1 12263
TK1 12261
AK2 12252
DBI 12235
OAZ2 12229
SCP2 12228
SDC1 12225
FDPS 12214
NUDT5 12208
ALDOC 12188
CYB5B 12186
TPI1 12173
LRP10 12167
MED8 12166
UQCRQ 12164
GPX1 12163
SLC16A3 12160
STARD3NL 12159
PRPS1 12154
SDHB 12152
CYCS 12143
PKM 12142
INPP5D 12108
CA12 12092
IDI1 12091
PSMA6 12089
ACAA2 12070
RPL39L 12068
HACD3 12063
PLBD1 12062
BPNT2 12057
HPRT1 12035
GLUL 12030
AMPD3 12028
NSDHL 12022
PPP2CA 12020
HK1 11994
RGL1 11988
COX7C 11984
PSME3 11980
GBA 11971
CYP11A1 11964
MED30 11959
DHCR7 11955
FH 11951
PCTP 11941
GSTK1 11936
CD44 11935
B4GALT5 11917
PGAM1 11916
LDLR 11911
GATM 11904
KCNS3 11897
PPT1 11896
PSMD12 11895
SDC3 11884
ENO1 11879
CHRM3 11878
NUP155 11877
NT5E 11870
COX8A 11860
OAT 11859
HS6ST2 11856
AHCY 11832
CHST2 11823
PSMA3 11818
NUDT15 11815
CYP26B1 11803
PSMA2 11784
DEGS1 11782
NUP37 11779
CHST13 11776
ACY1 11771
NNMT 11760
ASS1 11746
EEFSEC 11745
PSMD3 11738
LBR 11736
PSMB3 11727
HMGCR 11723
NDUFA4 11721
B4GALNT1 11720
QDPR 11719
GNG5 11713
B3GAT3 11712
NDUFB5 11704
NDUFS4 11701
AMD1 11693
AGPAT1 11689
GM2A 11683
STARD4 11682
AGK 11642
HS3ST4 11635
LGMN 11613
NUDT1 11608
MBTPS1 11598
ORMDL3 11580
SRD5A3 11568
CPT2 11566
MGLL 11563
NDC1 11558
SDHC 11556
PSMC1 11554
PRKAG2 11543
NDUFC2 11535
ACADM 11529
CHP1 11528
SAR1B 11525
PTGR1 11523
GOT1 11520
ATP5MC3 11518
ADCY1 11496
PAICS 11494
PSMD11 11493
VDR 11492
SLC46A1 11486
SLC25A11 11476
ACSL4 11475
GMPS 11474
RAN 11471
PSMB2 11467
PPA1 11461
MMAB 11459
TNFRSF21 11458
ARF3 11455
RPS29 11452
ALAS1 11445
PYCR2 11439
RPS27L 11435
ADIPOR2 11434
LDHA 11429
SEC13 11424
NDUFA2 11421
SULT1C2 11420
TACO1 11418
ACAD9 11417
CEMIP 11416
CHST11 11404
LPIN2 11402
HACD2 11393
NCOR2 11388
ACAT2 11377
UQCRC1 11375
TPST1 11369
ATP5PB 11353
KYAT3 11349
PTGR2 11347
GLTP 11342
SLC25A10 11325
AIMP2 11323
SUMF2 11317
HACL1 11310
COQ5 11277
IDH2 11276
SEC23A 11267
ATP5PF 11264
PLPP3 11259
GLYCTK 11258
NAXE 11252
GAA 11239
ADIPOR1 11235
GOT2 11232
GNS 11231
NDUFA12 11230
DUT 11228
GLB1 11226
MCCC1 11224
ARSG 11220
ORMDL2 11219
THTPA 11211
NQO1 11204
NDUFAF3 11202
DGUOK 11198
GMPR2 11196
RPL4 11190
ALDH9A1 11188
PLPP2 11180
ALDH7A1 11174
PIK3R4 11172
COX16 11162
CHPT1 11160
HACD1 11157
UROD 11148
RPS27A 11143
COX15 11142
MSMO1 11140
PTGES3 11137
RAE1 11135
SUCLG1 11128
RRM1 11127
NDUFA7 11121
ATP5F1E 11110
GRHL1 11109
GNB5 11106
GNG10 11100
GAMT 11098
PTGS2 11097
SAMHD1 11096
NR1H3 11083
FABP5 11072
PFKP 11068
CKMT1A 11066
LDHB 11062
GYG1 11054
DERA 11045
CYP1B1 11038
NUP58 11035
PSMB5 11025
GCH1 11018
CHST9 11005
PIP4K2A 11001
AHCYL1 10982
SQLE 10971
HEXB 10961
ADPGK 10960
MFSD2A 10957
ASRGL1 10956
PIK3R3 10955
HADHA 10951
PSMD13 10950
UGT8 10945
UBB 10939
NUP93 10937
CYB5A 10934
CSPG4 10932
MOCS2 10931
CHPF2 10916
HK2 10911
COX6C 10869
MLX 10863
RFK 10860
COX7A2L 10851
RPIA 10850
BPNT1 10848
SNAP25 10838
GAPDH 10833
COQ2 10825
ADK 10805
ISCA2 10799
PPP1CA 10780
PSMD10 10775
MTMR1 10773
RPS27 10764
PLA2G12A 10751
NDUFB4 10750
NUDT16 10746
PCCA 10732
VKORC1 10730
B4GALT7 10726
FHL2 10712
NAGLU 10710
GSTM4 10708
NDUFB9 10707
PSMC3 10692
NDUFA11 10691
HSD17B12 10679
MOCS1 10678
EXT1 10676
VAPA 10675
ELOVL2 10672
PSMC5 10666
DMAC2L 10638
ATP5MG 10628
BTD 10622
SCD 10612
SC5D 10579
PNPO 10569
ABHD14B 10560
SUMF1 10559
LYRM4 10545
MINPP1 10542
PIK3R1 10540
MED6 10534
BCHE 10530
DHTKD1 10528
UROS 10518
SLC27A3 10513
VAPB 10507
NME2 10491
RPS23 10485
GCSH 10475
SUMO2 10459
ADAL 10453
ELOVL7 10441
MED1 10436
PDZD11 10427
RPL41 10426
BCKDHA 10420
APOE 10411
L2HGDH 10401
CMPK1 10385
ACER3 10376
AHR 10375
GNB1 10374
TST 10370
OAZ1 10369
CDS2 10357
SLC6A11 10327
GDE1 10326
UMPS 10325
KPNB1 10321
PDHB 10313
PGP 10311
GLRX5 10305
CYP26A1 10295
PRKAR1A 10293
CAV1 10283
SPR 10281
ARNT2 10279
DHRS7B 10278
PSMA1 10273
CHDH 10267
RPSA 10265
RTEL1 10260
TYMP 10258
PNP 10254
B4GAT1 10249
NDUFB6 10245
LRP8 10243
GNG4 10242
DNPH1 10240
MED28 10239
AANAT 10237
MTMR10 10220
B3GNT2 10210
SLC27A2 10208
RPLP1 10204
ACBD7 10188
NDUFAF1 10186
PRKACA 10142
CIAPIN1 10132
COX14 10130
SUCLA2 10122
GCLM 10111
PPAT 10102
ARSB 10097
ASL 10096
HSD17B8 10095
PRKCA 10091
PRKACB 10089
SDC2 10088
GUSB 10083
G6PC3 10066
OGDH 10063
MARCKS 10055
GALC 10046
PHYH 10038
AK1 10036
PPP1CC 10035
MED4 10030
ELOVL6 10021
MMADHC 10017
ARF1 10007
MED24 9993
RPS24 9992
PSMB6 9989
ATP5F1A 9986
NDUFB8 9982
PDSS1 9980
PSMC6 9977
RPL27 9972
PI4KB 9962
ENPP2 9957
GPAM 9943
LYPLA1 9922
INPP5B 9915
PSMF1 9900
RPS7 9899
CSPG5 9897
GLO1 9893
TMLHE 9886
G0S2 9884
HS2ST1 9883
SDSL 9881
ACSF2 9875
PSAP 9866
PCYT1A 9849
CYP27B1 9847
ATP5F1B 9845
RBKS 9843
ALDH1L1 9820
ETFA 9819
GPC1 9816
COX7B 9811
BCKDHB 9796
ESD 9792
PPT2 9791
PDK2 9784
DPYD 9780
NDUFAF2 9779
CYP2S1 9771
SARDH 9764
GNG12 9738
GPD1L 9732
SGMS1 9719
PCBD1 9713
MPC2 9705
CHSY3 9699
ALDH18A1 9691
GLCE 9684
ABCB4 9683
CIAO2B 9681
PSMB4 9649
BRIP1 9639
BGN 9638
BST1 9630
PXMP2 9627
NHLRC1 9613
CHST7 9606
HADH 9601
PSMB1 9583
COX11 9581
CHST12 9548
CD320 9543
HSD17B7 9538
ENTPD7 9528
B3GALT6 9525
MVK 9523
HSD11B1 9519
GLS2 9516
SHMT1 9492
OSBPL10 9488
PSMC4 9483
SLC36A4 9474
RPL35A 9472
MED22 9471
NQO2 9469
PSMD8 9468
UQCR11 9467
HPSE 9466
TPK1 9446
PIK3CB 9440
PLEKHA6 9437
MAT2A 9416
EHHADH 9415
EXT2 9411
UCK2 9393
DCXR 9392
PRKAR2A 9391
UQCRH 9389
ABCB7 9375
OSBPL3 9366
BLVRA 9360
SUCLG2 9340
FXN 9330
RPL15 9329
OSBPL9 9324
CTPS1 9320
ATP5F1C 9306
FDXR 9301
PANK3 9287
HSP90AB1 9283
CYC1 9271
CERS2 9269
PSMD7 9260
PDHX 9244
PSMA7 9241
IDH3G 9230
GPC5 9226
MGST3 9225
MED27 9214
UGT3A2 9210
PMVK 9199
SLC25A15 9198
ADO 9178
SEC24A 9170
LCLAT1 9165
CPTP 9158
GMPR 9152
AKR7A2 9146
TALDO1 9139
SELENOI 9122
GSTZ1 9116
RPL21 9112
NAGS 9110
ARSA 9079
ACOX1 9060
CES1 9055
B4GALT3 9052
GNB4 9048
RPLP0 9040
RETSAT 9037
SLC44A2 9035
ECI2 9009
AK6 9005
NDUFB3 8999
SIN3A 8979
SPTSSA 8973
TXNRD1 8965
ATP5MC2 8959
CACNA2D2 8952
TDO2 8951
ACACA 8950
TBL1XR1 8942
HDAC3 8940
ATP5PD 8937
RPS28 8929
RPL30 8900
PYCR1 8876
CCNC 8867
SLC52A2 8866
MAT2B 8858
MGST1 8848
NDUFB7 8834
NADSYN1 8818
ACSL5 8815
CYP1A1 8806
SLC25A20 8805
GPAT3 8802
RPL39 8797
NDUFC1 8792
ACSS3 8771
COASY 8756
G6PD 8749
NDUFS7 8742
ACLY 8729
LPCAT2 8722
ISCA1 8703
TECR 8702
SGPP1 8701
OCA2 8700
DBH 8687
RPL36AL 8682
PSMD4 8653
CYP26C1 8633
NDUFA9 8604
HSD17B3 8599
PSMD1 8598
ME1 8589
MBOAT7 8577
ST3GAL1 8574
IVD 8570
RPL7 8557
SLC44A1 8555
LHPP 8543
RPS12 8531
CBR1 8528
B3GNT3 8518
PEX11A 8507
SLC35B2 8504
FIG4 8496
PLCE1 8469
PSMD14 8452
NMNAT1 8447
ARV1 8432
AGPS 8425
BCAN 8424
ALOX12B 8419
AK9 8416
RPL5 8413
FAR2 8408
ALDH6A1 8363
RDH11 8359
LPGAT1 8347
PDK4 8337
NDUFAB1 8321
PLAAT1 8316
RPS8 8313
ACBD6 8310
CERS6 8305
AK7 8295
TTPA 8294
COX4I1 8290
CHAC2 8279
COQ3 8274
PTPMT1 8268
RPL13A 8240
RORA 8239
NFYC 8230
SGMS2 8229
SORD 8220
RAB5A 8219
ALDH1B1 8212
PDSS2 8200
SERINC3 8199
ACBD4 8197
MIGA1 8195
XYLB 8184
UQCRFS1 8179
MVD 8178
ACOT11 8176
B3GNT7 8152
PSMA4 8117
CYP2J2 8115
GALK1 8107
MED7 8089
GSTM1 8087
SPTLC2 8057
ELOVL4 8055
SLC35D2 8050
AKAP5 8040
PTS 8026
QARS1 8019
CDS1 8018
NUDT19 7995
AACS 7992
NDST1 7980
PSMD2 7977
DLAT 7971
SLC25A19 7961
RPL19 7936
NDUFB1 7933
PSPH 7909
HADHB 7892
LRP1 7890
AOC1 7882
SPTLC1 7878
NT5C 7870
TPMT 7863
SERINC1 7857
COX6A1 7845
PDK1 7836
DGAT1 7829
SLC16A1 7826
ALDH4A1 7817
NPAS2 7814
ADI1 7802
HSD17B10 7784
ACOT2 7774
OXCT1 7746
MED31 7731
SLC25A44 7728
PUDP 7726
AUH 7716
MED21 7707
GLUD1 7688
CSNK2A1 7686
PPP1CB 7674
PARP14 7660
DCK 7645
PAPSS1 7635
GYG2 7634
KCNG2 7617
INPP1 7600
NUP153 7598
PGD 7595
GNPAT 7592
MLYCD 7587
ABCC3 7576
TPR 7550
ARSK 7545
VKORC1L1 7523
UBC 7520
MDH2 7508
CYP2U1 7496
PTPN13 7493
SCO2 7484
PLIN3 7456
PNMT 7446
MED19 7440
SDHD 7416
PARP8 7405
AGL 7382
HMBS 7363
GPHN 7362
RPL22 7316
FECH 7315
MID1IP1 7300
PSTK 7297
RPS26 7266
ABHD10 7260
PSMC2 7229
POLD1 7223
NDUFA1 7219
CDK8 7217
LRPPRC 7212
ATP5PO 7206
RPS21 7205
AASDHPPT 7191
PSMD9 7167
PPOX 7140
GLA 7127
RBP1 7113
RPS5 7111
RPL23 7085
SLC37A4 7077
PFKFB3 7075
GGPS1 7067
NDUFAF7 7058
RPL26L1 7054
TGS1 7052
NDUFB11 7017
LRP2 7014
B3GALT4 7012
SLC5A5 7010
VNN2 6997
PIP5K1B 6987
ADH5 6974
KHK 6967
RPL18A 6963
CA13 6941
RPS3 6933
PPP1R3C 6919
PPCS 6913
PLPP1 6903
NT5C3A 6889
RIDA 6884
IP6K1 6880
ACADL 6875
KARS1 6874
PPP2R1B 6872
TIMMDC1 6861
DDAH1 6853
PANK1 6849
PLA2R1 6827
INSIG2 6822
PLCD1 6808
HAGH 6807
KCNJ11 6806
HAS3 6801
STARD7 6773
SCAP 6762
NDUFS5 6761
NUP133 6741
PODXL2 6736
SRM 6728
TRMT112 6725
NDUFA13 6712
CYP17A1 6711
SARS1 6685
MTMR6 6682
CERT1 6679
PPIP5K1 6672
ELOVL5 6670
RPS16 6660
RPL3 6633
EPRS1 6632
HPD 6626
SLC25A1 6592
MMACHC 6582
DBT 6556
NUP85 6546
ACACB 6543
PECR 6515
HPGD 6507
GSS 6504
SPNS2 6477
RAP1A 6447
GNAI2 6444
FASN 6440
NUP43 6398
NUDT3 6349
RPS14 6310
SMARCD3 6307
COQ6 6298
GLIPR1 6280
IP6K2 6278
NUBPL 6271
CPOX 6268
RPL10 6263
GLDC 6247
ITPA 6246
ARNTL 6242
FUT1 6234
SLC44A3 6219
RAB14 6205
NAT1 6164
RPL22L1 6160
NUDT7 6147
RRM2B 6118
TNFAIP8L3 6107
ACADS 6106
SGSH 6097
TRIB3 6085
CBR3 6067
CHSY1 6050
GPD2 6047
PTGES2 6018
NUP42 6015
PRKG2 5985
PRPS2 5955
HIBADH 5933
MBTPS2 5920
RAB4A 5888
MED13 5885
ATP5F1D 5870
SURF1 5856
CHAT 5821
XYLT2 5817
ABHD3 5815
SLC2A3 5790
ADCY3 5789
TKT 5775
HMGCS1 5758
RPL7A 5755
MPC1 5749
PIK3CG 5716
UQCR10 5712
ENTPD5 5688
RPS20 5683
PANK4 5682
HSD11B2 5664
ST3GAL2 5645
MTHFD1 5633
FA2H 5600
HS3ST6 5590
RPS13 5560
BSG 5557
SLC35D1 5552
NUDT18 5514
ACP6 5505
FUT11 5487
DCTPP1 5473
DMGDH 5466
MED18 5453
MAPKAPK2 5441
ACOT1 5433
FPGS 5407
TPO 5394
PTDSS2 5371
IMPA1 5349
GUK1 5341
OSBPL8 5290
THEM4 5278
ECSIT 5274
PLEKHA1 5269
CYP39A1 5265
LIPE 5260
ESYT3 5241
ETNK2 5191
PLA2G10 5190
RPS19 5159
OXCT2 5155
IPMK 5147
MECR 5112
HOGA1 5078
ABCB1 5070
SPTLC3 5051
CHST1 5040
RPS3A 5004
PI4K2A 4992
CDA 4988
RPL26 4984
SLC9A1 4955
SLC25A32 4935
ABHD5 4887
IDH1 4854
PAPSS2 4850
FLAD1 4836
MTF1 4807
LPCAT1 4798
PTDSS1 4783
GSTM3 4766
HSD17B11 4735
GSTO1 4709
IDH3B 4704
SLC52A3 4667
CKMT2 4666
SHMT2 4655
SLC51B 4601
MED29 4592
SLC44A5 4589
PPM1L 4585
PARP16 4570
SLC25A16 4566
MED20 4554
GNG7 4509
ALOX15B 4508
CYB5R3 4500
INPP4B 4496
GNA11 4474
PLAAT2 4379
UGT1A1 4369
GART 4349
APIP 4348
NDUFS6 4346
PLD3 4327
GCK 4319
BCKDK 4317
CGA 4307
ACSL3 4295
RPS11 4282
MAOA 4256
DHODH 4234
EEF1E1 4229
SLC19A1 4223
PEMT 4218
RHCE 4204
PIK3R5 4203
ACOT13 4179
SERPINA6 4176
MED11 4169
NFYB 4164
RPS25 4151
SLC27A5 4144
PRXL2B 4125
CYP4F3 4100
ATP5MF 4075
NT5C1A 4054
GPX2 3978
GNAI1 3972
TPH2 3968
AK8 3944
GNGT2 3935
HS3ST5 3911
RPE 3892
NFS1 3881
HS6ST1 3866
HYAL2 3840
B3GALT1 3812
MTR 3776
NDUFS3 3752
SLC19A2 3707
RPL13 3702
BLVRB 3682
CARNMT1 3681
GSTP1 3652
CPT1A 3645
FITM2 3639
CACNA1D 3621
HS6ST3 3568
GDA 3495
TPST2 3493
MT-CO2 3466
CEPT1 3429
KYAT1 3382
SLC23A1 3364
PCYT2 3318
HMGCL 3314
PLA2G4F 3306
LMBRD1 3215
FUT9 3208
RPL10A 3181
PI4K2B 3176
ACHE 3171
AZIN1 3170
PSME2 3149
ETNPPL 3147
NUP88 3136
SCD5 3120
AGT 3117
FABP1 3095
CHST3 3094
CYP4B1 3088
SEM1 3082
PPARGC1A 3067
GLP1R 3052
MTHFD2 3046
NADK 3040
PIP4K2C 2961
STXBP1 2956
AMACR 2948
COQ9 2938
PSMB7 2916
GCAT 2857
DTYMK 2846
CYP1A2 2818
PSMB10 2792
ABCG2 2623
TDH 2616
GGT1 2582
ESYT2 2547
CYP2C19 2499
IDS 2486
PLCH1 2461
PLEKHA8 2372
MTMR14 2370
NEU1 2346
STARD6 2337
RPL38 2281
ACER2 2266
MT-CO1 2218
PTGDS 2216
ATP5ME 2212
SLC22A13 2200
ARNT 2188
MT-ATP8 2186
LPL 2175
SLC25A13 2099
SLC25A21 2063
ASAH2 2057
ADH6 2031
UCK1 2029
GGT5 2024
VAC14 1982
CPNE3 1891
UQCRB 1884
SLC22A1 1879
ADCY9 1734
ACADSB 1675
GLB1L 1674
NAT8L 1593
THRAP3 1581
HYKK 1548
SLCO1A2 1534
CSNK2B 1532
ABHD4 1495
IDO1 1448
TM7SF2 1445
SDHA 1401
INPP5A 1398
ACSF3 1375
LRAT 1362
FABP2 1346
APOM 1337
MPST 1330
LPIN3 1300
NDUFA8 1250
GNA14 1226
ALOX12 1224
IPPK 1223
SAMD8 1222
PRKAR2B 1208
LIPT2 1192
OPLAH 1147
FDFT1 1131
LRP12 1101
CDIPT 1085
N6AMT1 1047
RPL36A 1011
B3GAT2 1009
ALOX5 1005
GLYATL1 998
PITPNM3 990
RPLP2 960
ALDOA 956
HMOX2 905
PRKD3 873
TECRL 852
FDX1 845
PPIP5K2 786
ETFDH 778
ADCY5 763
NDUFV2 696
ACY3 556
INPP5K 476
PLA2G15 450
NAALAD2 440
PCK1 419
RPL32 418
HSD3B2 369
DCT 367
STS 351
RPL6 348
MTARC2 344
FAM120B 326
SEPHS2 321
HAAO 307
KCNB1 305
ENPP6 293
MT-ATP6 266
CBSL 216
NUP35 208
CYP2R1 198
PSMD6 140
CLOCK 122
ACSL6 93
SLC51A 88
PNPLA8 84
HIBCH 39
CA7 12
SLC26A2 -6
UPB1 -9
MCEE -80
PARP9 -101
PPARA -116
CYP19A1 -120
NDUFAF4 -130
AGMO -157
NDUFAF5 -160
AMDHD1 -170
UBIAD1 -196
FDX2 -206
PLA2G4D -249
PLD4 -253
SULT2A1 -275
NOSTRIN -292
ABCC8 -325
NUP214 -329
NDUFA5 -387
FABP4 -427
GSTT2 -442
OCRL -449
RPL27A -460
FLVCR1 -479
PLCB3 -529
AGPAT2 -556
AKR1A1 -575
CERS1 -640
GNAS -692
HSD17B13 -764
PRODH -794
ASPA -839
BHMT -929
PAOX -936
AKT1 -942
SLC25A14 -966
CES2 -984
NUDT4 -1034
RPL24 -1041
CACNA1C -1064
SEC24D -1137
NDUFS2 -1149
CYP4F12 -1270
CTSA -1275
UGT2A1 -1289
PLCB1 -1307
ADCY4 -1345
ALOX15 -1376
DUOX1 -1385
FMO1 -1393
ADSL -1412
PSME1 -1500
GCDH -1556
LDHAL6A -1561
ACSM6 -1571
NOSIP -1592
UGT3A1 -1598
CTRB2 -1616
CYP2C18 -1625
CYP51A1 -1635
PIP5K1A -1637
MTMR2 -1727
NOS3 -1756
STARD5 -1767
POR -1803
SPTSSB -1813
MTHFD2L -1833
NUDT13 -1841
MAN2B1 -1845
CBR4 -1862
AFMID -1947
TMEM126B -1954
NDUFV3 -1980
TAT -1992
UCP3 -2025
UBA52 -2054
CRLS1 -2079
WASL -2126
RNLS -2137
COX6B1 -2140
PRELP -2168
HS3ST2 -2187
GNA15 -2228
B4GALT4 -2266
RPL14 -2302
MTARC1 -2303
GSTM5 -2327
CTRB1 -2337
ARG1 -2345
RPL29 -2351
NUDT9 -2393
OSBPL1A -2397
HACD4 -2425
LDHC -2448
B4GALNT2 -2460
PLA2G4E -2524
HAL -2608
KMO -2617
LTC4S -2618
ALDH2 -2644
ENPP1 -2688
NUDT12 -2711
NDUFS1 -2730
ENOPH1 -2775
SDS -2786
DLD -2805
GPI -2878
UPP2 -2905
NDST3 -2911
TCN1 -2913
IDH3A -2920
PIK3R2 -2955
MCCC2 -2979
TNFAIP8L1 -3032
CRYL1 -3036
AKR1D1 -3092
CROT -3133
TTR -3152
NDUFA6 -3174
ITPKB -3213
MOGAT3 -3225
CYP46A1 -3272
LTA4H -3290
CDO1 -3302
CD38 -3323
COQ7 -3324
GNG3 -3338
PTGIS -3347
HNMT -3405
CACNA1E -3409
COQ10A -3410
CYP8B1 -3420
ADIPOQ -3427
DPYS -3444
DARS1 -3530
COX5B -3541
PFKL -3546
IDO2 -3560
OSBP -3589
UGDH -3651
STAR -3673
IQGAP1 -3678
PARP4 -3692
MTHFS -3700
ACBD5 -3702
CRYM -3726
ACOX3 -3834
LHB -3863
CTRC -3865
CYP2W1 -3954
ESYT1 -3963
AKR1B15 -3965
FBP2 -3980
COQ10B -4036
ETNK1 -4138
DDO -4155
CKM -4173
TXN -4278
ITPK1 -4283
TXN2 -4298
DNM2 -4376
TPTE2 -4519
NCAN -4538
CYP7B1 -4552
MOCS3 -4556
MTMR12 -4569
PCYT1B -4576
GDPD1 -4619
CYP4F8 -4624
ACSBG2 -4649
FUT6 -4654
PLA1A -4675
MCAT -4681
ENPP3 -4705
HSD17B1 -4707
NME4 -4721
HSD3B1 -4735
PHGDH -4742
CYP2B6 -4744
ACOT9 -4748
GRHPR -4756
NUP98 -4774
NCOA2 -4776
ALAD -4786
SGPP2 -4806
GGT6 -4817
RPL11 -4818
MT-ND6 -4822
ITPR2 -4885
HGD -4905
SECISBP2 -4909
STARD3 -4924
ARSD -4980
PDK3 -4995
MT-ND5 -4997
UQCRC2 -5023
MTMR7 -5035
SREBF2 -5072
CHST5 -5077
SLC52A1 -5086
MAN2B2 -5107
OSBPL7 -5109
SMS -5124
MMS19 -5143
FMO3 -5165
AOX1 -5178
PRKAB2 -5183
PANK2 -5219
RPS15A -5253
CERS3 -5319
ACAA1 -5321
RARS1 -5338
PFKFB2 -5366
PPM1K -5396
NR1H4 -5408
SP1 -5422
BAAT -5452
PFKFB1 -5456
ADH1B -5458
SEC24B -5466
GALT -5479
GGT7 -5496
SULT1C4 -5511
PGLS -5532
MTAP -5609
NUBP2 -5634
CHST6 -5640
RPL3L -5663
GLYATL2 -5817
DIO1 -5818
AGMAT -5860
MT-CO3 -5871
SRR -5891
UCKL1 -5908
CIAO1 -5914
RPS9 -5925
NDUFA3 -5928
UPP1 -5956
LIPH -5966
FAU -5971
ANKRD1 -5973
SEH1L -5984
NMNAT3 -5994
GNPDA2 -6026
DCN -6100
MED16 -6102
ASAH1 -6117
AADAC -6152
ELOVL1 -6166
AGXT -6167
SYNJ1 -6174
CIDEC -6188
LDHAL6B -6242
ABO -6250
ACSM3 -6313
GPC2 -6341
TKFC -6368
CYP3A5 -6404
OMD -6406
NUDT10 -6443
SLC23A2 -6446
PYGL -6464
SLC35B3 -6539
CH25H -6541
COX20 -6582
AIMP1 -6616
CA3 -6620
MMUT -6630
AGRN -6676
INMT -6708
CD36 -6799
CYP24A1 -6809
SLC19A3 -6821
BDH1 -6838
OSBPL2 -6859
PSME4 -6905
GPAT2 -6915
PLEKHA5 -6918
ACOT6 -6928
INPP5F -6934
AZIN2 -6941
GPT -6947
UGT1A7 -6960
MAN2C1 -7024
UBE2I -7071
MT-ND4 -7077
SULT2B1 -7084
ST3GAL4 -7096
GDPD5 -7116
PI4KA -7142
HELZ2 -7160
PPP2R1A -7177
PPA2 -7178
GCKR -7196
OAZ3 -7199
LIAS -7290
RPS10 -7365
HSCB -7371
SUOX -7377
ENTPD1 -7388
SLC44A4 -7418
RPL35 -7428
ACOT4 -7440
IYD -7482
CERS4 -7492
EPHX2 -7520
ACP5 -7534
SLC22A5 -7556
MTMR4 -7564
AS3MT -7570
ACSM2A -7571
UROC1 -7575
MED9 -7632
ETHE1 -7637
APOC2 -7652
NR1D1 -7665
NUP160 -7666
NDUFS8 -7676
RPL8 -7687
MRI1 -7692
NUBP1 -7708
SCO1 -7776
GNG11 -7787
CA6 -7880
MED14 -7945
ALDOB -7977
ACSBG1 -7981
NUDT11 -7992
NDUFAF6 -8002
MT-CYB -8003
TIAM2 -8032
ACAT1 -8037
MT-ND1 -8061
PON2 -8071
IMPDH2 -8095
SEC24C -8103
PLEKHA4 -8119
GADL1 -8121
NUP107 -8135
INPP4A -8166
FAHD1 -8168
GNG13 -8180
SACM1L -8191
UST -8217
B3GNT4 -8231
AIP -8251
CYP4F11 -8254
GCLC -8272
ABCD1 -8301
NDOR1 -8323
PRKD2 -8345
APOA1 -8363
ME2 -8374
ST3GAL3 -8398
GNB2 -8407
SULT1A2 -8413
SMPD2 -8416
NDST2 -8433
ISCU -8462
DHFR2 -8466
CIAO3 -8484
PIK3C3 -8514
NCOA6 -8521
ENTPD8 -8524
PIK3CA -8536
PNPLA4 -8570
PFAS -8621
KDSR -8623
PGS1 -8629
SERINC5 -8635
SULT1A1 -8636
CYP3A43 -8653
FUT2 -8656
PTGS1 -8707
MT-ND2 -8787
ACOXL -8795
PDP2 -8808
CDK19 -8855
CA5B -8867
MAOB -8885
PRKAA2 -8900
MTM1 -8908
DEGS2 -8944
TCN2 -8951
AAAS -8985
PIAS4 -8986
PSMD5 -8988
RPS4X -8997
CRAT -9027
PGM2 -9080
PRSS1 -9083
FUT5 -9116
CES3 -9119
GNMT -9126
NADK2 -9155
PLCD4 -9192
NUP54 -9221
FABP6 -9229
NCOA1 -9240
RPL36 -9255
TPH1 -9278
ALDH3B1 -9285
MED10 -9308
PLCG2 -9310
BCAT2 -9313
HYAL3 -9315
RPS6 -9318
NUP188 -9339
PLCD3 -9368
PNPLA2 -9376
STK11 -9379
RPS15 -9442
SLC26A1 -9445
PLCB2 -9446
ACOX2 -9494
NDUFB10 -9509
PIK3C2B -9525
RPL12 -9556
HTD2 -9593
TMEM186 -9598
RPL34 -9603
MTHFR -9608
CS -9622
NR1H2 -9627
PHOSPHO1 -9632
GSTT2B -9637
PCK2 -9688
PNPLA3 -9697
RPL37 -9709
RAPGEF4 -9714
TSPOAP1 -9716
HYAL1 -9718
NUP62 -9736
RIMKLB -9768
COX18 -9772
LPCAT4 -9794
GNG2 -9804
PSMB8 -9809
ME3 -9829
MED26 -9832
PPARGC1B -9909
MBOAT2 -9910
COX10 -9911
NDUFV1 -9973
PC -9989
CARNS1 -9990
PYGM -9994
PHKA1 -10003
CSNK2A2 -10004
RPS17 -10017
SLC6A12 -10029
RPL31 -10046
ACADVL -10062
VAMP2 -10096
SREBF1 -10102
ALOXE3 -10135
AKR7A3 -10136
FITM1 -10155
EPM2A -10168
HSD17B14 -10171
RHD -10189
ADPRM -10218
GPD1 -10246
B3GAT1 -10256
SLC37A1 -10319
GPS2 -10343
ABCD4 -10369
COMT -10381
MED15 -10400
ABCC2 -10413
PHKG1 -10421
IMPDH1 -10425
PHYKPL -10432
SRD5A1 -10437
SMPD3 -10450
RPL28 -10480
ACSM2B -10495
PGAM2 -10497
BPHL -10503
SLC25A12 -10565
COX19 -10574
NRF1 -10576
CHD9 -10577
PIK3C2A -10590
PLIN1 -10596
SLC25A27 -10622
ADRA2C -10626
CHKB -10630
NEU3 -10644
RPS18 -10647
NCOA3 -10654
PPP2R5D -10673
SPHK2 -10682
GSTO2 -10696
MED12 -10697
DGAT2 -10715
NMRAL1 -10716
FUT10 -10730
LPIN1 -10741
HSD17B2 -10752
RPL9 -10760
NT5C2 -10777
DSEL -10778
ALB -10803
CA2 -10816
FOLH1 -10817
GLUD2 -10826
PRKD1 -10840
CA14 -10841
PLPP6 -10936
CAD -10940
VNN1 -10945
BCAT1 -10956
MIOX -10992
IMPA2 -11003
PLEKHA3 -11008
ARSJ -11015
MT-ND3 -11022
PSMB9 -11036
PRKAR1B -11042
SULT1A4 -11070
ARSI -11102
AGPAT5 -11131
TSPO -11138
KYNU -11160
ALDH3A2 -11170
PDXK -11180
PIPOX -11181
CBS -11193
NAPRT -11198
AADAT -11206
SLC25A28 -11209
BCO2 -11234
PITPNB -11239
GPX4 -11250
SHPK -11264
DUOX2 -11302
THEM5 -11305
ACAD8 -11307
IARS1 -11325
AKR7L -11326
B4GALT6 -11343
SLC25A17 -11348
RPL18 -11409
EPHX1 -11436
CTH -11443
RANBP2 -11459
DECR1 -11460
CUBN -11472
NAXD -11476
SBF2 -11479
ERCC2 -11494
GPT2 -11505
RUFY1 -11509
SMPD1 -11546
ITPKC -11553
PDHA1 -11566
B4GALT2 -11583
TNFAIP8 -11600
GNAQ -11615
ACSS1 -11634
MED13L -11673
MTHFD1L -11677
TBL1X -11686
MTMR9 -11687
NNT -11690
FUT4 -11691
DCTD -11719
HS3ST3A1 -11742
FAH -11748
XDH -11749
RPL37A -11759
GK -11785
RPS2 -11806
DLST -11839
FAAH -11893
NMRK1 -11901
MED17 -11909
PHKG2 -11912
SGPL1 -11921
PLCH2 -11939
ECI1 -11952
RPL17 -11954
FAR1 -12024
PPP2CB -12032
SLC27A1 -12047
SEPSECS -12066
GYS1 -12080
ADA -12093
DSE -12098
POM121C -12113
ADHFE1 -12130
CERK -12153
LIPT1 -12156
OSBPL5 -12158
IDUA -12184
MAT1A -12202
PLB1 -12206
CYP2D6 -12232
ENTPD6 -12234
AKR1C2 -12236
PNPLA7 -12238
ST6GALNAC6 -12240
SYNJ2 -12245
CACNB2 -12262
MED23 -12279
CMBL -12281
HLCS -12286
MMAA -12295
MED25 -12297
PTEN -12299
PTGES -12309
PISD -12335
POM121 -12347
RXRA -12352
PLCB4 -12357
CYP4V2 -12361
OSBPL6 -12370
ATIC -12374
D2HGDH -12407
NFYA -12422
ACAD10 -12426
NUP50 -12432
ADRA2A -12459
B3GALT5 -12463
LSS -12489
INPP5J -12512
ACSL1 -12514
AMN -12515
FABP3 -12518
ENO3 -12523
ADCY6 -12527
NEU4 -12529
SCLY -12538
ACO2 -12540
MTRR -12554
CSNK1G2 -12608
CERS5 -12623
DDHD1 -12649
PDPR -12652
EP300 -12670
GPC6 -12672
CHAC1 -12676
SULT1B1 -12684
PIP5K1C -12755
CTPS2 -12762
GNPDA1 -12764
PLA2G4B -12774
PLEKHA2 -12776
SBF1 -12779
CYP21A2 -12785
ZDHHC21 -12814
MARS1 -12820
FTCD -12823
ODC1 -12824
SMOX -12833
DECR2 -12866
GNB3 -12867
SULT1A3 -12881
PLD6 -12984
CYP27A1 -12994
ACAN -13003
ACOT8 -13007
ISYNA1 -13020
XYLT1 -13052
ABCC5 -13056
PLA2G4A -13086
MBOAT1 -13093
PIK3CD -13104
CPNE1 -13115
EBP -13118
SPHK1 -13123
TRAP1 -13125
AASS -13137
TMEM86B -13139
B4GALT1 -13141
MTMR3 -13170
ABCC1 -13193
AGPAT3 -13197
GSTA4 -13214
NT5M -13227
CSGALNACT2 -13251
AKR1C1 -13255
AMPD2 -13284
MIGA2 -13287
ENTPD3 -13289
ITPKA -13324
PLA2G5 -13326
RXRB -13337
PSAT1 -13349
PLA2G4C -13351
PARP6 -13387
ITPR3 -13411
HMOX1 -13431
SLC5A6 -13435
AMT -13461
GPAT4 -13464
PIKFYVE -13479
BDH2 -13480
CHKA -13500
LARS1 -13510
ACAD11 -13516
SLC3A2 -13519
GSR -13531
SLC7A5 -13536
HS3ST3B1 -13537
ITPR1 -13544
CPT1B -13545
MORC2 -13551
NME3 -13557
FUT3 -13572
PIP4K2B -13606
NDUFA10 -13615
ENO2 -13619
HSD3B7 -13620
ESRRA -13635
ADCY2 -13655
ORMDL1 -13665
CYP2E1 -13666
TAZ -13685
CREBBP -13739
CSAD -13757
GDPD3 -13770
ENTPD4 -13771
PLD2 -13778
GBA2 -13794
RAPGEF3 -13837
CPS1 -13843
PFKM -13854
PITPNM1 -13866
STARD10 -13887
DIO2 -13889
CPNE7 -13906
CARM1 -13918
ABCA1 -13932
CACNB3 -13947
ALDH1L2 -13948
SULT4A1 -13953
PHKB -13967
CHPF -13979
SYT5 -13983
SMPD4 -13992
PNPLA6 -14011
DDAH2 -14012
ADCY7 -14015
NCOR1 -14040
GLS -14043
ARG2 -14089
BPGM -14112
DDHD2 -14127
CACNA1A -14135
ECHS1 -14139
AOC3 -14149
PARP10 -14157
PPARD -14180
GSTM2 -14192
PGM2L1 -14200
PITPNM2 -14207
ETFB -14250
INPP5E -14257
SLC25A37 -14266
IL4I1 -14275
AK5 -14304
CNDP2 -14320
MLXIPL -14325
AOC2 -14338
HSPG2 -14349
TK2 -14361
PHKA2 -14399
SIN3B -14402
PRSS3 -14407
GPCPD1 -14410
PLA2G6 -14412
STX1A -14429
CA9 -14432
CSGALNACT1 -14436
AGPAT4 -14446
MANBA -14447
PYGB -14448
ASNS -14454
AKR1C3 -14455
INPPL1 -14466
SAT1 -14469
ACSS2 -14479
QPRT -14487
AHRR -14491
ST3GAL6 -14499
VCAN -14505
PLCG1 -14507
HAS2 -14524


PTEN Regulation

PTEN Regulation
16
set PTEN Regulation
setSize 140
pANOVA 0.00367
s.dist 0.142
p.adjustANOVA 0.00678



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPARG 12736
RHEB 12630
MKRN1 12515
PSMA5 12432
PSMA6 12089
RRAGA 12012
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
LAMTOR5 11685
PHC2 11658
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
RRAGD 11053
PSMB5 11025

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPARG 12736
RHEB 12630
MKRN1 12515
PSMA5 12432
PSMA6 12089
RRAGA 12012
PSME3 11980
PSMD12 11895
PSMA3 11818
PSMA2 11784
PSMD3 11738
PSMB3 11727
LAMTOR5 11685
PHC2 11658
PSMC1 11554
PSMD11 11493
PSMB2 11467
RPS27A 11143
RRAGD 11053
PSMB5 11025
PSMD13 10950
UBB 10939
PSMD10 10775
RNF2 10717
PSMC3 10692
VAPA 10675
PSMC5 10666
CBX4 10451
EZH2 10310
PSMA1 10273
PSMB6 9989
PSMC6 9977
LAMTOR1 9960
RBBP4 9908
PSMF1 9900
PSMB4 9649
PSMB1 9583
PSMC4 9483
PSMD8 9468
MTA3 9291
PSMD7 9260
PSMA7 9241
EED 9041
WWP2 8971
HDAC3 8940
PSMD4 8653
PSMD1 8598
PSMD14 8452
EGR1 8144
PSMA4 8117
AKT3 8039
LAMTOR2 8007
PSMD2 7977
NEDD4 7948
CSNK2A1 7686
UBC 7520
PSMC2 7229
PSMD9 7167
PREX2 7123
LAMTOR3 6791
MTOR 6555
JUN 6468
RBBP7 6317
SLC38A9 6124
USP13 5641
RCOR1 5294
SNAI1 4778
HDAC1 4759
HDAC2 4701
KDM1A 4533
BMI1 4473
PSME2 3149
SEM1 3082
PML 3054
PSMB7 2916
PSMB10 2792
MAPK1 2648
RPTOR 2038
CSNK2B 1532
CBX2 705
PSMD6 140
LAMTOR4 -46
MECOM -433
AKT1 -942
SCMH1 -1190
GATAD2B -1299
PSME1 -1500
NR2E1 -1750
UBA52 -2054
REST -2568
MAF1 -3294
CBX8 -4190
GATAD2A -4394
TNKS2 -5681
XIAP -6638
FRK -6873
PSME4 -6905
PHC3 -8041
TNRC6C -8274
ATF2 -8741
PSMD5 -8988
AGO1 -9002
TP53 -9081
CNOT6L -9218
RRAGC -9224
AGO3 -9248
MTA1 -9799
PSMB8 -9809
CSNK2A2 -10004
CHD4 -10167
AGO4 -10917
MTA2 -10964
CBX6 -10993
HDAC7 -11016
PSMB9 -11036
PTENP1 -11262
MAPK3 -11289
RRAGB -11312
RNF146 -11341
SUZ12 -11388
RING1 -11882
HDAC5 -11973
AGO2 -12096
PHC1 -12273
PTEN -12299
TRIM27 -12331
SNAI2 -12472
MLST8 -12519
TNRC6A -12667
ATN1 -12942
TNRC6B -12976
CHD3 -12981
STUB1 -13102
TNKS -13136
OTUD3 -13254
MOV10 -13419
MBD3 -13632
AKT2 -13775
USP7 -14021
SALL4 -14489


Nervous system development

Nervous system development
13
set Nervous system development
setSize 527
pANOVA 1.48e-07
s.dist 0.133
p.adjustANOVA 4.45e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
CACNA1S 12749
LAMA1 12715
KRAS 12711
NTN1 12706
EPHA2 12703
RPS6KA1 12690
SEMA6A 12688
GDNF 12672
ITGB3 12658
LAMC1 12655
HSP90AA1 12629
EFNA5 12611
SEMA7A 12590
L1CAM 12572
PFN2 12519
ITGA9 12510
NELL2 12482
ADGRG6 12440
PSMA5 12432
GAP43 12416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CACNA1S 12749
LAMA1 12715
KRAS 12711
NTN1 12706
EPHA2 12703
RPS6KA1 12690
SEMA6A 12688
GDNF 12672
ITGB3 12658
LAMC1 12655
HSP90AA1 12629
EFNA5 12611
SEMA7A 12590
L1CAM 12572
PFN2 12519
ITGA9 12510
NELL2 12482
ADGRG6 12440
PSMA5 12432
GAP43 12416
RPL23A 12415
NGEF 12411
ADAM10 12378
EFNB1 12343
ITGB1 12330
CAP1 12272
ITGA1 12241
SLIT3 12203
PLXNA1 12199
NCBP2 12178
UNC5A 12168
SHC1 12151
SPTBN1 12128
MAP2K1 12093
PSMA6 12089
AP2B1 12082
RPL39L 12068
EIF4A3 12036
ABLIM1 12018
KIF4A 12013
DPYSL5 12002
PSME3 11980
AP2S1 11958
CLTC 11948
CACNA1G 11937
PSMD12 11895
LHX2 11840
LHX4 11829
PSMA3 11818
ACTR2 11794
PSMA2 11784
ALCAM 11758
PSMD3 11738
PSMB3 11727
HMGCR 11723
NEO1 11649
ARPC5 11616
PSMC1 11554
NRP1 11552
PSMD11 11493
PSMB2 11467
RPS29 11452
RPS27L 11435
MSN 11389
GRB2 11361
WWTR1 11316
EPHB1 11315
ACTG1 11261
ETF1 11240
APH1B 11194
RPL4 11190
CDK5 11168
PFN1 11167
MYH10 11144
RPS27A 11143
PSMB5 11025
MSI1 11020
SLIT1 10983
COL6A2 10979
RBM8A 10976
PIK3R3 10955
PSMD13 10950
COL4A1 10947
COL4A2 10943
UBB 10939
DAG1 10936
RAC1 10892
MMP2 10871
GFRA2 10835
CFL1 10782
PSMD10 10775
GSK3B 10766
RPS27 10764
RHOA 10745
PRNP 10722
PSMC3 10692
PSMC5 10666
APH1A 10641
SEMA4D 10626
CNTN1 10621
MYL6 10548
PIK3R1 10540
RPS23 10485
RHOB 10480
ROCK2 10435
RPL41 10426
CACNA1H 10424
MYL12A 10378
ELOC 10337
CD24 10291
PSMA1 10273
SHANK3 10270
RPSA 10265
ISL1 10264
PLXND1 10214
RPLP1 10204
MYL12B 10199
USP33 10165
SCN4B 10163
PRKACA 10142
PRKCA 10091
PRKACB 10089
SDC2 10088
CDC42 10084
RPS24 9992
PSMB6 9989
NCK1 9987
PSENEN 9981
PSMC6 9977
RPL27 9972
EGR2 9948
PSMF1 9900
RPS7 9899
EFNA2 9879
PAK2 9865
GPC1 9816
SOS2 9807
ACTR3 9757
PSMB4 9649
PSMB1 9583
ACTB 9571
PSMC4 9483
RPL35A 9472
PSMD8 9468
PIK3CB 9440
EFNA1 9396
PRKAR2A 9391
SH3KBP1 9364
CUL2 9345
RPL15 9329
ITGA2 9288
HSP90AB1 9283
PSMD7 9260
PSMA7 9241
MAGOH 9132
RPL21 9112
RPLP0 9040
PAK5 9027
LYN 8955
RAP1GAP 8931
RPS28 8929
NRAS 8912
RPL30 8900
PTPN11 8869
NCBP1 8822
ARPC4 8807
RPL39 8797
UNC5C 8780
RPL36AL 8682
PSMD4 8653
PSMD1 8598
DOCK1 8575
RPL7 8557
PABPC1 8534
RPS12 8531
PAK4 8498
PSMD14 8452
RPL5 8413
SDCBP 8383
AP2A1 8365
ARPC3 8334
NCSTN 8328
RPS8 8313
RPL13A 8240
CLTB 8228
ST8SIA4 8204
EPHA6 8191
PSMA4 8117
AP2M1 8116
SCN5A 8104
ABL2 8074
AKAP5 8040
PSMD2 7977
RPL19 7936
SH3GL2 7815
ENAH 7762
CSNK2A1 7686
KCNQ3 7672
UPF2 7636
SIAH2 7620
VAV3 7569
PMP22 7524
UBC 7520
MAGOHB 7448
DAB1 7447
NCAM1 7414
PLXNC1 7348
RPL22 7316
PSEN1 7309
RPS26 7266
PSMC2 7229
RPS21 7205
AGAP2 7178
PSMD9 7167
RDX 7153
RHOC 7120
RPS5 7111
RPL23 7085
RPL26L1 7054
CAP2 7018
RPL18A 6963
ROCK1 6957
RPS3 6933
MET 6868
ABLIM2 6754
RPS16 6660
DPYSL4 6645
RPL3 6633
ADGRV1 6621
CASC3 6570
UPF3B 6564
PLXNA4 6495
LHX9 6492
SIAH1 6479
RPS14 6310
CREB1 6277
RPL10 6263
LYPLA2 6226
EGFR 6184
RPL22L1 6160
COL6A5 6144
IRS2 6103
MBP 5984
MAPK8 5868
RANBP9 5835
DNM3 5812
RPL7A 5755
CNTN2 5738
RPS20 5683
ARHGAP35 5671
RPS13 5560
DLG1 5465
SCN9A 5368
PSEN2 5253
RPS19 5159
DOK1 5139
RPS3A 5004
RPL26 4984
HDAC2 4701
SHTN1 4515
COL6A1 4395
PAK3 4376
RPS11 4282
RPS25 4151
VLDLR 4069
EFNB2 3857
PRKCQ 3773
RPL13 3702
CACNA1D 3621
GRIN2B 3291
RPL10A 3181
PSME2 3149
SCD5 3120
SEM1 3082
DPYSL3 3080
SMARCA4 3019
PSMB7 2916
PSMB10 2792
MAPK1 2648
SCN7A 2598
RPL38 2281
NFASC 1653
MYL9 1557
DOK6 1537
CSNK2B 1532
VASP 1387
RPS6KA3 1172
UTRN 1074
RPL36A 1011
RPLP2 960
SPTAN1 898
POU3F1 789
SRGAP1 674
COL6A6 574
RPL32 418
GRB7 364
RPL6 348
ITGAV 193
EIF4G1 182
MAPK14 181
PSMD6 140
RBX1 -331
EPHB3 -364
RPL27A -460
EPHA10 -463
EPHA1 -588
EFNA4 -969
RPL24 -1041
CACNA1C -1064
ARHGEF28 -1169
EVL -1277
FRS2 -1323
PSME1 -1500
PITPNA -1550
CYP51A1 -1635
ZSWIM8 -2045
UBA52 -2054
WASL -2126
RPS6KA6 -2223
SCN1A -2260
RPL14 -2302
RPL29 -2351
TRPC5 -2410
COL9A1 -2431
PIK3R2 -2955
GIT1 -2985
POU3F2 -3095
NCK2 -3432
ARPC1A -3440
SCN2B -3498
GAB2 -3528
GSPT1 -3647
GSPT2 -4148
SOX10 -4193
SEMA3A -4220
EPHA8 -4292
DNM2 -4376
NCAN -4538
RPL11 -4818
CLTA -4933
SREBF2 -5072
TRPC1 -5142
RPS15A -5253
EFNB3 -5255
VAV2 -5478
ABL1 -5509
RPL3L -5663
CACNB4 -5816
ARHGAP39 -5855
RPS9 -5925
FAU -5971
PAK6 -5981
SCN8A -6014
NRTN -6050
PPP3CB -6238
TRPC3 -6270
SCN2A -6426
UNC5D -6557
AGRN -6676
GRIN1 -6716
HSPA8 -6720
NRCAM -6853
PSME4 -6905
COL4A5 -6955
KCNQ2 -7028
GFRA1 -7272
HRAS -7282
RPS10 -7365
RPL35 -7428
MAPK11 -7476
EPHA7 -7537
ROBO2 -7624
RPL8 -7687
FLRT3 -7761
MYH11 -7891
MAP2K2 -7901
CXCR4 -7912
CLTCL1 -7935
DPYSL2 -8050
RND1 -8157
SCN3A -8307
SPTB -8316
ITGA2B -8389
CDK5R1 -8396
NTN4 -8425
PIK3CA -8536
ERBB2 -8591
RET -8628
LIMK1 -8668
LIMK2 -8677
RASA1 -8832
ARTN -8895
PLXNB3 -8921
MYH14 -8975
PSMD5 -8988
RPS4X -8997
SPTBN2 -9048
DOK4 -9175
SEMA6D -9209
RPL36 -9255
RPS6 -9318
SPTBN5 -9407
TIAM1 -9425
RPS15 -9442
EFNA3 -9451
SPTBN4 -9510
SRGAP2 -9543
RPL12 -9556
RPL34 -9603
DCC -9695
RPL37 -9709
ST8SIA2 -9790
PSMB8 -9809
GAB1 -9824
EZR -9896
SEMA4A -9984
CSNK2A2 -10004
RPS17 -10017
UNC5B -10045
RPL31 -10046
CACNA1I -10074
SOS1 -10165
RGMB -10173
HOXA2 -10216
AP2A2 -10344
RPL28 -10480
RPS18 -10647
PRX -10677
RPS6KA5 -10683
RPL9 -10760
SCN3B -10966
PSMB9 -11036
TEAD1 -11048
ARHGEF12 -11061
PSPN -11108
RNPS1 -11270
MAPK3 -11289
ARPC2 -11355
ELOB -11356
RPL18 -11409
NUMB -11575
RPS6KA4 -11593
TRPC4 -11601
RGMA -11612
COL4A3 -11755
RPL37A -11759
RPS2 -11806
ANK1 -11947
RPL17 -11954
SRGAP3 -11994
TRIO -11995
DNM1 -12022
ANK2 -12035
MAPK7 -12147
ITSN1 -12186
SCN11A -12196
CACNB2 -12262
NAB2 -12334
YES1 -12364
MYH9 -12436
KALRN -12553
COL4A4 -12567
DRP2 -12575
CD72 -12578
SLIT2 -12616
UPF3A -12618
PTK2 -12647
YAP1 -12668
ITGA5 -12703
MAPK13 -12744
PIP5K1C -12755
CACNB1 -12807
CRMP1 -12887
ARHGEF11 -13000
FES -13001
ARHGEF7 -13019
SHC3 -13032
LAMA2 -13045
CLASP2 -13054
DOK5 -13055
DLG3 -13098
PIK3CD -13104
PTPRA -13105
ROBO3 -13106
FYN -13113
RPS6KA2 -13127
RELN -13200
ARPC1B -13201
SCN1B -13218
TLN1 -13261
ROBO1 -13301
RRAS -13328
MAPK12 -13409
LDB1 -13462
CXCL12 -13495
EPHB2 -13696
ABLIM3 -13780
NAB1 -13839
ANK3 -13861
PAK1 -13863
PDLIM7 -13921
SRC -13925
CACNB3 -13947
COL9A3 -13991
EPHB4 -14000
EPHA4 -14101
MYO10 -14143
DSCAML1 -14165
GRB10 -14197
CLASP1 -14232
FGFR1 -14246
PLXNA3 -14253
DLG4 -14318
COL9A2 -14321
COL6A3 -14360
SEMA5A -14363
CNTNAP1 -14386
LAMB1 -14393
PLXNA2 -14417
MYO9B -14434
PLXNB1 -14450
FARP2 -14490
EPHB6 -14500
PLCG1 -14507
NRP2 -14522
MMP9 -14523
ITGA10 -14525


Mitochondrial biogenesis

Mitochondrial biogenesis
7
set Mitochondrial biogenesis
setSize 91
pANOVA 0.101
s.dist 0.0993
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5MC1 12573
SSBP1 12527
CALM1 12384
CHCHD3 12245
CYCS 12143
IMMT 11977
MICOS10 11913
GABPB1 11824
PRKAG2 11543
ATP5MC3 11518
ALAS1 11445
ATP5PB 11353
IDH2 11276
ATP5PF 11264
ATP5F1E 11110
MTX1 10918
DMAC2L 10638
ATP5MG 10628
MED1 10436
HSPA9 10341

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MC1 12573
SSBP1 12527
CALM1 12384
CHCHD3 12245
CYCS 12143
IMMT 11977
MICOS10 11913
GABPB1 11824
PRKAG2 11543
ATP5MC3 11518
ALAS1 11445
ATP5PB 11353
IDH2 11276
ATP5PF 11264
ATP5F1E 11110
MTX1 10918
DMAC2L 10638
ATP5MG 10628
MED1 10436
HSPA9 10341
TFAM 10164
ATP5F1A 9986
ATP5F1B 9845
CHCHD6 9836
PRKAG1 9421
ATP5F1C 9306
CAMK4 9003
ATP5MC2 8959
TBL1XR1 8942
HDAC3 8940
ATP5PD 8937
TFB2M 8894
SIRT4 8076
GLUD1 7688
ATP5PO 7206
TGS1 7052
SIRT5 7026
SMARCD3 6307
CREB1 6277
APOOL 5972
ATP5F1D 5870
ATP5MF 4075
TMEM11 3852
PERM1 3360
PPARGC1A 3067
ATP5ME 2212
MT-ATP8 2186
SAMM50 1470
HCFC1 1329
APOO 466
MT-ATP6 266
MAPK14 181
PPARA -116
PRKAB1 -3884
MEF2D -4290
NCOA2 -4776
MICOS13 -4921
PRKAB2 -5183
PPRC1 -5730
HELZ2 -7160
MAPK11 -7476
NR1D1 -7665
CRTC2 -8044
NCOA6 -8521
ATF2 -8741
GABPA -8814
PRKAA2 -8900
NCOA1 -9240
POLG2 -9498
PPARGC1B -9909
DNAJC11 -10517
NRF1 -10576
CHD9 -10577
GLUD2 -10826
MTERF1 -10954
POLRMT -11449
TBL1X -11686
MTX2 -11908
TFB1M -12007
SOD2 -12012
RXRA -12352
CRTC1 -12396
MEF2C -13168
MAPK12 -13409
SIRT3 -13594
ESRRA -13635
CREBBP -13739
CARM1 -13918
NCOR1 -14040
CRTC3 -14105
ACSS2 -14479


Nucleotide biosynthesis

Nucleotide biosynthesis
14
set Nucleotide biosynthesis
setSize 12
pANOVA 0.693
s.dist 0.0659
p.adjustANOVA 0.792



Top enriched genes

Top 20 genes
GeneID Gene Rank
PAICS 11494
GMPS 11474
UMPS 10325
PPAT 10102
GART 4349
DHODH 4234
ADSL -1412
IMPDH2 -8095
PFAS -8621
IMPDH1 -10425
CAD -10940
ATIC -12374

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAICS 11494
GMPS 11474
UMPS 10325
PPAT 10102
GART 4349
DHODH 4234
ADSL -1412
IMPDH2 -8095
PFAS -8621
IMPDH1 -10425
CAD -10940
ATIC -12374


Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
19
set Receptor Mediated Mitophagy
setSize 11
pANOVA 0.798
s.dist 0.0445
p.adjustANOVA 0.82



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP1LC3B 8827
ATG5 8732
PGAM5 8457
CSNK2A1 7686
FUNDC1 5889
ATG12 4621
CSNK2B 1532
CSNK2A2 -10004
MAP1LC3A -10700
SRC -13925
ULK1 -14214

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP1LC3B 8827
ATG5 8732
PGAM5 8457
CSNK2A1 7686
FUNDC1 5889
ATG12 4621
CSNK2B 1532
CSNK2A2 -10004
MAP1LC3A -10700
SRC -13925
ULK1 -14214


Oxidative Stress Induced Senescence

Oxidative Stress Induced Senescence
15
set Oxidative Stress Induced Senescence
setSize 83
pANOVA 0.513
s.dist -0.0415
p.adjustANOVA 0.616



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2BC5 -13970
MINK1 -13915
MOV10 -13419
CDK6 -13366
TNRC6B -12976
H2BC12 -12804
TNRC6A -12667
H2BC21 -12639
PHC1 -12273
H2BC15 -12037
RING1 -11882
E2F3 -11703
FOS -11685
H2AC6 -11570
MAP3K5 -11394
SUZ12 -11388
MAPK3 -11289
MAP2K7 -11214
CBX6 -10993
AGO4 -10917

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC5 -13970.0
MINK1 -13915.0
MOV10 -13419.0
CDK6 -13366.0
TNRC6B -12976.0
H2BC12 -12804.0
TNRC6A -12667.0
H2BC21 -12639.0
PHC1 -12273.0
H2BC15 -12037.0
RING1 -11882.0
E2F3 -11703.0
FOS -11685.0
H2AC6 -11570.0
MAP3K5 -11394.0
SUZ12 -11388.0
MAPK3 -11289.0
MAP2K7 -11214.0
CBX6 -10993.0
AGO4 -10917.0
H2BC4 -10445.0
H2BC11 -9792.0
MAP4K4 -9629.0
H2BC17 -9361.0
AGO3 -9248.0
MAP2K4 -9103.0
TP53 -9081.0
AGO1 -9002.0
TNRC6C -8274.0
MAPKAPK5 -8234.0
MDM4 -8181.0
PHC3 -8041.0
MAPK11 -7476.0
H2AC7 -6363.0
KDM6B -5975.0
H2AC18 -5612.0
H2BC13 -5322.0
TXN -4278.0
CBX8 -4190.0
CDKN2C -4044.0
MAP2K3 -3839.0
CDKN2D -3193.0
UBA52 -2054.0
H2AB1 -1222.0
SCMH1 -1190.0
MAPKAPK3 -1007.0
MAPK9 -389.0
MAPK14 181.0
CBX2 705.0
MAPK1 2648.0
MAP2K6 2677.0
H3C1 2799.0
H2AC14 3575.0
H3C15 3858.5
BMI1 4473.0
H2BC9 4551.0
MAPKAPK2 5441.0
MAPK8 5868.0
H2BU1 6039.0
RBBP7 6317.0
JUN 6468.0
UBC 7520.0
MAPK10 8426.0
CDK4 9010.0
EED 9041.0
RBBP4 9908.0
H2AC20 10125.0
E2F1 10289.0
EZH2 10310.0
H3-3A 10446.0
CBX4 10451.0
E2F2 10551.0
RNF2 10717.0
UBB 10939.0
H2AZ1 11047.0
RPS27A 11143.0
TNIK 11284.0
H2AJ 11383.0
TFDP1 11600.0
PHC2 11658.0
MDM2 11926.0
TFDP2 12250.0
H2AZ2 12469.0


Gene Silencing by RNA

Gene Silencing by RNA
4
set Gene Silencing by RNA
setSize 98
pANOVA 0.759
s.dist 0.0179
p.adjustANOVA 0.82



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90AA1 12629
TDRKH 12591
NUP210 12555
NUP205 12488
H2AZ2 12469
POLR2L 12317
NUP155 11877
NUP37 11779
HENMT1 11763
POLR2K 11614
NDC1 11558
RAN 11471
SEC13 11424
H2AJ 11383
POLR2C 11159
RAE1 11135
H2AZ1 11047
NUP58 11035
NUP93 10937
POLR2G 10585

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90AA1 12629.0
TDRKH 12591.0
NUP210 12555.0
NUP205 12488.0
H2AZ2 12469.0
POLR2L 12317.0
NUP155 11877.0
NUP37 11779.0
HENMT1 11763.0
POLR2K 11614.0
NDC1 11558.0
RAN 11471.0
SEC13 11424.0
H2AJ 11383.0
POLR2C 11159.0
RAE1 11135.0
H2AZ1 11047.0
NUP58 11035.0
NUP93 10937.0
POLR2G 10585.0
H3-3A 10446.0
IPO8 10296.0
H2AC20 10125.0
POLR2H 9951.0
MYBL1 9942.0
TSNAX 9777.0
POLR2E 8987.0
POLR2B 8936.0
NUP153 7598.0
TPR 7550.0
DICER1 7407.0
NUP133 6741.0
ANG 6713.0
NUP85 6546.0
NUP43 6398.0
H2BU1 6039.0
NUP42 6015.0
H2BC9 4551.0
TARBP2 3991.0
H3C15 3858.5
H2AC14 3575.0
POLR2D 3369.0
NUP88 3136.0
POLR2I 2877.0
H3C1 2799.0
POLR2F 2706.0
POLR2A 921.0
NUP35 208.0
NUP214 -329.0
TSN -812.0
H2AB1 -1222.0
POLR2J -1668.0
ASZ1 -3720.0
NUP98 -4774.0
TDRD12 -4966.0
H2BC13 -5322.0
H2AC18 -5612.0
SEH1L -5984.0
H2AC7 -6363.0
FKBP6 -6442.0
TDRD6 -7173.0
BCDIN3D -7485.0
NUP160 -7666.0
NUP107 -8135.0
TNRC6C -8274.0
AAAS -8985.0
AGO1 -9002.0
PIWIL1 -9166.0
NUP54 -9221.0
AGO3 -9248.0
NUP188 -9339.0
H2BC17 -9361.0
NUP62 -9736.0
H2BC11 -9792.0
H2BC4 -10445.0
AGO4 -10917.0
RANBP2 -11459.0
PRKRA -11528.0
H2AC6 -11570.0
DDX4 -11671.0
TDRD9 -11911.0
H2BC15 -12037.0
AGO2 -12096.0
POM121C -12113.0
POM121 -12347.0
NUP50 -12432.0
H2BC21 -12639.0
TNRC6A -12667.0
H2BC12 -12804.0
ELAC2 -12885.0
DROSHA -12896.0
TNRC6B -12976.0
PLD6 -12984.0
XPO5 -13297.0
PIWIL4 -13432.0
DGCR8 -13554.0
H2BC5 -13970.0
PIWIL2 -14087.0


Phospholipid metabolism

Phospholipid metabolism
17
set Phospholipid metabolism
setSize 193
pANOVA 0.82
s.dist -0.0095
p.adjustANOVA 0.82



Top enriched genes

Top 20 genes
GeneID Gene Rank
INPPL1 -14466
AGPAT4 -14446
PLA2G6 -14412
GPCPD1 -14410
INPP5E -14257
PITPNM2 -14207
DDHD2 -14127
PNPLA6 -14011
CPNE7 -13906
STARD10 -13887
PITPNM1 -13866
PLD2 -13778
GDPD3 -13770
TAZ -13685
PIP4K2B -13606
CHKA -13500
PIKFYVE -13479
GPAT4 -13464
PLA2G4C -13351
PLA2G5 -13326

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INPPL1 -14466
AGPAT4 -14446
PLA2G6 -14412
GPCPD1 -14410
INPP5E -14257
PITPNM2 -14207
DDHD2 -14127
PNPLA6 -14011
CPNE7 -13906
STARD10 -13887
PITPNM1 -13866
PLD2 -13778
GDPD3 -13770
TAZ -13685
PIP4K2B -13606
CHKA -13500
PIKFYVE -13479
GPAT4 -13464
PLA2G4C -13351
PLA2G5 -13326
MIGA2 -13287
AGPAT3 -13197
MTMR3 -13170
TMEM86B -13139
CPNE1 -13115
PIK3CD -13104
MBOAT1 -13093
PLA2G4A -13086
PLD6 -12984
SBF1 -12779
PLEKHA2 -12776
PLA2G4B -12774
PIP5K1C -12755
DDHD1 -12649
INPP5J -12512
PISD -12335
PTEN -12299
SYNJ2 -12245
PNPLA7 -12238
PLB1 -12206
OSBPL5 -12158
MTMR9 -11687
TNFAIP8 -11600
RUFY1 -11509
SBF2 -11479
PITPNB -11239
AGPAT5 -11131
PLEKHA3 -11008
LPIN1 -10741
DGAT2 -10715
CHKB -10630
PIK3C2A -10590
GPD1 -10246
CSNK2A2 -10004
MBOAT2 -9910
LPCAT4 -9794
PNPLA3 -9697
PHOSPHO1 -9632
PIK3C2B -9525
PNPLA2 -9376
MTM1 -8908
PGS1 -8629
PIK3CA -8536
PIK3C3 -8514
SACM1L -8191
INPP4A -8166
PLEKHA4 -8119
MTMR4 -7564
SLC44A4 -7418
PI4KA -7142
GDPD5 -7116
INPP5F -6934
PLEKHA5 -6918
GPAT2 -6915
SYNJ1 -6174
LIPH -5966
MTMR7 -5035
PLA1A -4675
GDPD1 -4619
PCYT1B -4576
MTMR12 -4569
TPTE2 -4519
ETNK1 -4138
TNFAIP8L1 -3032
PIK3R2 -2955
PLA2G4E -2524
CRLS1 -2079
MTMR2 -1727
PIP5K1A -1637
AGPAT2 -556
OCRL -449
PLD4 -253
PLA2G4D -249
PNPLA8 84
ENPP6 293
PLA2G15 450
INPP5K 476
PITPNM3 990
CDIPT 1085
LPIN3 1300
ABHD4 1495
CSNK2B 1532
CPNE3 1891
VAC14 1982
MTMR14 2370
PLEKHA8 2372
PIP4K2C 2961
ETNPPL 3147
ACHE 3171
PI4K2B 3176
PLA2G4F 3306
PCYT2 3318
CEPT1 3429
PIK3R5 4203
PEMT 4218
PLD3 4327
PLAAT2 4379
INPP4B 4496
SLC44A5 4589
PTDSS1 4783
LPCAT1 4798
PI4K2A 4992
PLA2G10 5190
ETNK2 5191
PLEKHA1 5269
OSBPL8 5290
PTDSS2 5371
ACP6 5505
PIK3CG 5716
ABHD3 5815
CHAT 5821
RAB4A 5888
GPD2 6047
TNFAIP8L3 6107
RAB14 6205
SLC44A3 6219
MTMR6 6682
STARD7 6773
PLA2R1 6827
PIP5K1B 6987
PTPN13 7493
GNPAT 7592
CSNK2A1 7686
DGAT1 7829
HADHB 7892
CDS1 8018
MIGA1 8195
RAB5A 8219
PTPMT1 8268
PLAAT1 8316
LPGAT1 8347
FIG4 8496
SLC44A1 8555
MBOAT7 8577
LPCAT2 8722
GPAT3 8802
SLC44A2 9035
SELENOI 9122
LCLAT1 9165
PLEKHA6 9437
PIK3CB 9440
OSBPL10 9488
GPD1L 9732
PCYT1A 9849
GPAM 9943
PI4KB 9962
ARF1 10007
MTMR10 10220
GDE1 10326
CDS2 10357
BCHE 10530
PIK3R1 10540
PLA2G12A 10751
MTMR1 10773
HADHA 10951
PIK3R3 10955
MFSD2A 10957
PIP4K2A 11001
CHPT1 11160
PIK3R4 11172
LPIN2 11402
ARF3 11455
MGLL 11563
AGK 11642
AGPAT1 11689
PCTP 11941
PLBD1 12062
INPP5D 12108
PLAAT4 12266
LPCAT3 12373
PLD1 12574
PIK3R6 12650
PLAAT3 12737


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.8         
##  [49] XML_3.99-0.9           sass_0.4.0             dbplyr_2.1.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.2            later_1.3.0           
##  [58] AnnotationDbi_1.54.1   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.0            cachem_1.0.6           cli_3.2.0             
##  [64] generics_0.1.2         RSQLite_2.2.10         broom_0.7.12          
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.37             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.32.0        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.0         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.70.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] desc_1.4.1             lattice_0.20-45        Matrix_1.4-1          
##  [88] vctrs_0.3.8            pillar_1.7.0           lifecycle_1.0.1       
##  [91] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [94] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [97] KernSmooth_2.23-20     gridExtra_2.3          assertthat_0.2.1      
## [100] rprojroot_2.0.2        withr_2.5.0            GenomeInfoDbData_1.2.6
## [103] hms_1.1.1              grid_4.2.0             rmarkdown_2.13        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report