Mitch Report

date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     x
## 5_8S_rRNA  12.9204273
## 7SK         1.4582210
## A1BG        2.1192797
## A1BG-AS1    6.5771976
## A1CF       -0.2475616
## A2M       -10.7739590

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	24
num_genes_in_profile	26741
duplicated_genes_present	0
num_profile_genes_in_sets	2751
num_profile_genes_not_in_sets	23990

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:

Gene sets metrics

	Gene sets metrics
num_genesets	24
num_genesets_excluded	0
num_genesets_included	24

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 24 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Receptor Mediated Mitophagy	11	3.03e-03	-0.5160	5.19e-03
Complex I biogenesis	57	5.81e-11	0.5010	4.65e-10
Nucleotide biosynthesis	12	2.86e-03	-0.4970	5.19e-03
Mitophagy	28	3.87e-05	-0.4490	1.03e-04
Reduction of cytosolic Ca++ levels	12	2.00e-02	-0.3880	3.20e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	53	2.86e-06	-0.3710	8.59e-06
Signaling by the B Cell Receptor (BCR)	105	6.48e-09	-0.3280	2.59e-08
PTEN Regulation	140	1.10e-09	-0.2980	5.30e-09
Respiratory electron transport	103	8.33e-07	0.2810	2.86e-06
Phospholipid metabolism	191	2.89e-10	-0.2640	1.74e-09
Mitochondrial biogenesis	91	2.97e-04	-0.2190	7.13e-04
Nervous system development	529	5.20e-16	-0.2050	6.24e-15
Gene Silencing by RNA	98	7.25e-04	-0.1970	1.58e-03
Resolution of D-Loop Structures	33	6.25e-02	0.1870	7.90e-02
Stabilization of p53	53	3.60e-02	-0.1660	5.16e-02
Cellular response to starvation	150	1.71e-03	0.1480	3.43e-03
Oxidative Stress Induced Senescence	83	3.65e-02	-0.1330	5.16e-02
Metabolism	1899	2.72e-18	-0.1200	6.54e-17
Mitochondrial iron-sulfur cluster biogenesis	13	4.68e-01	-0.1160	5.10e-01
Mitochondrial translation	96	9.66e-02	0.0981	1.16e-01
Mucopolysaccharidoses	11	6.01e-01	0.0912	6.01e-01
Mitochondrial protein import	64	2.76e-01	-0.0787	3.16e-01
Diseases of carbohydrate metabolism	31	5.17e-01	-0.0673	5.39e-01
Metabolism of amino acids and derivatives	344	4.42e-02	0.0630	5.89e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Receptor Mediated Mitophagy	11	3.03e-03	-0.5160	5.19e-03
Complex I biogenesis	57	5.81e-11	0.5010	4.65e-10
Nucleotide biosynthesis	12	2.86e-03	-0.4970	5.19e-03
Mitophagy	28	3.87e-05	-0.4490	1.03e-04
Reduction of cytosolic Ca++ levels	12	2.00e-02	-0.3880	3.20e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	53	2.86e-06	-0.3710	8.59e-06
Signaling by the B Cell Receptor (BCR)	105	6.48e-09	-0.3280	2.59e-08
PTEN Regulation	140	1.10e-09	-0.2980	5.30e-09
Respiratory electron transport	103	8.33e-07	0.2810	2.86e-06
Phospholipid metabolism	191	2.89e-10	-0.2640	1.74e-09
Mitochondrial biogenesis	91	2.97e-04	-0.2190	7.13e-04
Nervous system development	529	5.20e-16	-0.2050	6.24e-15
Gene Silencing by RNA	98	7.25e-04	-0.1970	1.58e-03
Resolution of D-Loop Structures	33	6.25e-02	0.1870	7.90e-02
Stabilization of p53	53	3.60e-02	-0.1660	5.16e-02
Cellular response to starvation	150	1.71e-03	0.1480	3.43e-03
Oxidative Stress Induced Senescence	83	3.65e-02	-0.1330	5.16e-02
Metabolism	1899	2.72e-18	-0.1200	6.54e-17
Mitochondrial iron-sulfur cluster biogenesis	13	4.68e-01	-0.1160	5.10e-01
Mitochondrial translation	96	9.66e-02	0.0981	1.16e-01
Mucopolysaccharidoses	11	6.01e-01	0.0912	6.01e-01
Mitochondrial protein import	64	2.76e-01	-0.0787	3.16e-01
Diseases of carbohydrate metabolism	31	5.17e-01	-0.0673	5.39e-01
Metabolism of amino acids and derivatives	344	4.42e-02	0.0630	5.89e-02

---

Detailed Gene set reports

Receptor Mediated Mitophagy

Receptor Mediated Mitophagy

	19
set	Receptor Mediated Mitophagy
setSize	11
pANOVA	0.00303
s.dist	-0.516
p.adjustANOVA	0.00519

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2A1	-10886
CSNK2A2	-10253
PGAM5	-9947
ATG5	-9563
SRC	-7851
MAP1LC3B	-7619
ATG12	-6372
ULK1	-2897
MAP1LC3A	-203
FUNDC1	4763
CSNK2B	7911

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2A1	-10886
CSNK2A2	-10253
PGAM5	-9947
ATG5	-9563
SRC	-7851
MAP1LC3B	-7619
ATG12	-6372
ULK1	-2897
MAP1LC3A	-203
FUNDC1	4763
CSNK2B	7911

---

Complex I biogenesis

Complex I biogenesis

	2
set	Complex I biogenesis
setSize	57
pANOVA	5.81e-11
s.dist	0.501
p.adjustANOVA	4.65e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NDUFA3	15362
NDUFB1	15346
NDUFA1	15253
NDUFV2	15224
MT-ND3	15179
NDUFS5	15132
NDUFAF3	15110
NDUFA7	15075
NDUFB8	14960
MT-ND2	14490
NDUFS8	14487
NDUFA13	14484
NDUFA2	14481
ACAD9	14402
NDUFA8	14321
NDUFB4	14290
MT-ND1	14264
MT-ND5	14139
MT-ND4	14079
MT-ND6	13969

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NDUFA3	15362
NDUFB1	15346
NDUFA1	15253
NDUFV2	15224
MT-ND3	15179
NDUFS5	15132
NDUFAF3	15110
NDUFA7	15075
NDUFB8	14960
MT-ND2	14490
NDUFS8	14487
NDUFA13	14484
NDUFA2	14481
ACAD9	14402
NDUFA8	14321
NDUFB4	14290
MT-ND1	14264
MT-ND5	14139
MT-ND4	14079
MT-ND6	13969
NDUFA12	13944
NDUFA6	13790
NDUFS7	13575
NDUFA11	13563
NDUFS3	13204
NDUFB10	12853
NDUFV3	12653
NDUFAF2	12597
NDUFB7	12482
NDUFS6	12427
NDUFAF6	12264
NDUFB2	12149
NDUFC1	12063
NDUFB3	11906
COA1	11532
NDUFV1	11451
NDUFA5	11096
NDUFB9	9766
NDUFA10	9639
NDUFAF5	9415
NDUFAF7	8918
NDUFB11	7425
NDUFA9	6256
ECSIT	-357
TMEM126B	-638
TMEM186	-1524
NDUFB6	-1580
TIMMDC1	-1624
NDUFAF1	-2299
NDUFAF4	-2437
NDUFC2	-4456
NDUFS4	-6131
NUBPL	-6610
NDUFAB1	-7080
NDUFS2	-7766
NDUFS1	-7990
NDUFB5	-8339

---

Nucleotide biosynthesis

Nucleotide biosynthesis

	14
set	Nucleotide biosynthesis
setSize	12
pANOVA	0.00286
s.dist	-0.497
p.adjustANOVA	0.00519

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GART	-10865
PPAT	-10764
CAD	-10359
PAICS	-10007
GMPS	-9558
IMPDH2	-8822
UMPS	-6785
IMPDH1	-5534
ATIC	-5401
ADSL	-3836
DHODH	12613
PFAS	14665

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GART	-10865
PPAT	-10764
CAD	-10359
PAICS	-10007
GMPS	-9558
IMPDH2	-8822
UMPS	-6785
IMPDH1	-5534
ATIC	-5401
ADSL	-3836
DHODH	12613
PFAS	14665

---

Mitophagy

Mitophagy

	11
set	Mitophagy
setSize	28
pANOVA	3.87e-05
s.dist	-0.449
p.adjustANOVA	0.000103

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2A1	-10886
TOMM20	-10705
TOMM70	-10645
CSNK2A2	-10253
PGAM5	-9947
PINK1	-9749
ATG5	-9563
MFN1	-9365
MFN2	-9245
SRC	-7851
VDAC1	-7693
MAP1LC3B	-7619
TOMM7	-7580
UBC	-6964
ATG12	-6372
TOMM22	-5449
RPS27A	-5160
SQSTM1	-5159
TOMM6	-5003
UBB	-3180

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2A1	-10886
TOMM20	-10705
TOMM70	-10645
CSNK2A2	-10253
PGAM5	-9947
PINK1	-9749
ATG5	-9563
MFN1	-9365
MFN2	-9245
SRC	-7851
VDAC1	-7693
MAP1LC3B	-7619
TOMM7	-7580
UBC	-6964
ATG12	-6372
TOMM22	-5449
RPS27A	-5160
SQSTM1	-5159
TOMM6	-5003
UBB	-3180
ULK1	-2897
MAP1LC3A	-203
TOMM5	353
FUNDC1	4763
CSNK2B	7911
UBA52	11501
MTERF3	13676
TOMM40	13798

---

Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels

	20
set	Reduction of cytosolic Ca++ levels
setSize	12
pANOVA	0.02
s.dist	-0.388
p.adjustANOVA	0.032

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP2A2	-11228
ATP2B4	-11147
ATP2B1	-10821
CALM1	-9971
SRI	-7871
ATP2A3	-6143
SLC8A2	-5230
SLC8A1	-5067
SLC8A3	-1533
ATP2B2	5244
ATP2A1	13052
ATP2B3	13602

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP2A2	-11228
ATP2B4	-11147
ATP2B1	-10821
CALM1	-9971
SRI	-7871
ATP2A3	-6143
SLC8A2	-5230
SLC8A1	-5067
SLC8A3	-1533
ATP2B2	5244
ATP2A1	13052
ATP2B3	13602

---

Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle

	18
set	Pyruvate metabolism and Citric Acid (TCA) cycle
setSize	53
pANOVA	2.86e-06
s.dist	-0.371
p.adjustANOVA	8.59e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDH2	-11079
ME2	-10846
SLC16A1	-10783
PDK1	-10697
CS	-10604
SDHA	-10529
SUCLG2	-10244
MDH2	-9964
LDHA	-9876
L2HGDH	-9769
OGDH	-9550
DLD	-9398
DLAT	-9330
DLST	-9257
PDHX	-8778
SLC16A3	-8234
PDP2	-8204
SUCLA2	-8074
PDK3	-7909
VDAC1	-7693

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDH2	-11079
ME2	-10846
SLC16A1	-10783
PDK1	-10697
CS	-10604
SDHA	-10529
SUCLG2	-10244
MDH2	-9964
LDHA	-9876
L2HGDH	-9769
OGDH	-9550
DLD	-9398
DLAT	-9330
DLST	-9257
PDHX	-8778
SLC16A3	-8234
PDP2	-8204
SUCLA2	-8074
PDK3	-7909
VDAC1	-7693
SDHB	-7529
NNT	-7468
PDP1	-7399
ME1	-7369
SDHC	-7321
SDHD	-7213
GLO1	-6860
IDH3A	-6427
LDHB	-6384
RXRA	-6096
IDH3B	-5545
FH	-4807
MPC2	-4708
PDPR	-4544
SUCLG1	-3607
IDH3G	-1805
ME3	504
PDK4	1456
PDHB	3379
LDHAL6B	3617
LDHC	3789
LDHAL6A	4524
FAHD1	5378
ACO2	7258
PDK2	7726
MPC1	9409
GSTZ1	10128
PPARD	10370
PDHA1	11421
ADHFE1	13162
BSG	13431
D2HGDH	14030
HAGH	14302

---

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

	23
set	Signaling by the B Cell Receptor (BCR)
setSize	105
pANOVA	6.48e-09
s.dist	-0.328
p.adjustANOVA	2.59e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITPR1	-11274
PSME4	-11141
NCK1	-11135
FBXW11	-11036
ORAI1	-10945
GRB2	-10928
RELA	-10834
NFKB1	-10739
PSMD1	-10668
NFATC3	-10658
PPP3R1	-10428
PSMD2	-10307
NFATC1	-10216
AHCYL1	-10203
SKP1	-10099
CALM1	-9971
REL	-9908
ITPR2	-9789
BCL10	-9714
PSMD3	-9689

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITPR1	-11274
PSME4	-11141
NCK1	-11135
FBXW11	-11036
ORAI1	-10945
GRB2	-10928
RELA	-10834
NFKB1	-10739
PSMD1	-10668
NFATC3	-10658
PPP3R1	-10428
PSMD2	-10307
NFATC1	-10216
AHCYL1	-10203
SKP1	-10099
CALM1	-9971
REL	-9908
ITPR2	-9789
BCL10	-9714
PSMD3	-9689
PSMA7	-9678
PSMD11	-9552
PIK3R1	-9444
NRAS	-9293
PSMD7	-8924
PSMD5	-8901
SOS1	-8846
PSMD8	-8841
PSMF1	-8503
PSMA5	-8382
PPP3CB	-8357
BTRC	-8147
PSMC1	-8097
PSMA2	-8025
PSME3	-7994
SH3KBP1	-7843
PSMB5	-7716
CHUK	-7482
CUL1	-7356
PSMD14	-7340
KRAS	-7194
FYN	-7099
PSMD10	-7034
PSMA6	-6980
UBC	-6964
PSMC6	-6903
PSMD9	-6748
NFKBIA	-6715
NFATC2	-6641
MAP3K7	-6572
NFKBIE	-6257
STIM1	-6237
PSMB2	-6126
ITPR3	-6102
PSMA1	-6072
ORAI2	-5890
PPP3CA	-5776
PSMD12	-5542
RPS27A	-5160
RASGRP1	-4850
PSMA4	-4415
TRPC1	-4339
PSMB6	-3827
PIK3CD	-3823
PIK3AP1	-3717
UBB	-3180
PLCG2	-2906
CD79A	-2548
LYN	-2496
PSMC2	-2444
BLK	-1952
PRKCB	-1752
RASGRP3	-252
NFKBIB	1144
PSMD13	2181
PSME1	4473
PSMB8	4550
FKBP1A	5097
VAV1	5381
CD22	5666
PSMA3	6151
BTK	6237
IKBKG	6893
BLNK	7343
SYK	7802
PSMB1	7962
MALT1	9127
PSMB9	9240
PSMC5	9697
PTPN6	10385
CARD11	10392
PSMD4	10510
PSMC3	10621
PSMC4	10904
UBA52	11501
PSMB7	11959
PSMD6	12288
PSMB4	13901
PSMB10	13932
PPIA	14363
PSMB3	14498
SEM1	14859
HRAS	14873
PSME2	14893
IKBKB	15367

---

PTEN Regulation

PTEN Regulation

	16
set	PTEN Regulation
setSize	140
pANOVA	1.1e-09
s.dist	-0.298
p.adjustANOVA	5.3e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSME4	-11141
GATAD2B	-11012
MAPK1	-10995
RCOR1	-10908
CSNK2A1	-10886
RRAGC	-10870
REST	-10822
AGO2	-10781
RRAGD	-10673
PSMD1	-10668
AKT3	-10477
TNKS	-10471
RNF2	-10434
PSMD2	-10307
CSNK2A2	-10253
VAPA	-10085
PSMD3	-9689
PSMA7	-9678
PHC3	-9669
KDM1A	-9592

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSME4	-11141
GATAD2B	-11012
MAPK1	-10995
RCOR1	-10908
CSNK2A1	-10886
RRAGC	-10870
REST	-10822
AGO2	-10781
RRAGD	-10673
PSMD1	-10668
AKT3	-10477
TNKS	-10471
RNF2	-10434
PSMD2	-10307
CSNK2A2	-10253
VAPA	-10085
PSMD3	-9689
PSMA7	-9678
PHC3	-9669
KDM1A	-9592
PSMD11	-9552
GATAD2A	-9532
AGO3	-9480
TNKS2	-9338
MKRN1	-9267
USP7	-9197
BMI1	-9016
MAPK3	-8949
PSMD7	-8924
EGR1	-8915
PSMD5	-8901
PSMD8	-8841
CHD4	-8762
LAMTOR1	-8761
ATF2	-8550
HDAC2	-8521
PSMF1	-8503
CNOT6L	-8499
TNRC6B	-8468
PHC2	-8445
TRIM27	-8436
PSMA5	-8382
PSMC1	-8097
PSMA2	-8025
PSME3	-7994
RRAGA	-7858
PSMB5	-7716
RHEB	-7617
EED	-7597
CBX4	-7569
HDAC5	-7448
XIAP	-7350
PSMD14	-7340
PTEN	-7317
RBBP7	-7306
OTUD3	-7269
PML	-7200
RBBP4	-7153
PSMD10	-7034
PSMA6	-6980
UBC	-6964
PSMC6	-6903
USP13	-6876
PSMD9	-6748
PSMB2	-6126
PSMA1	-6072
MLST8	-5916
HDAC3	-5788
PSMD12	-5542
AGO1	-5490
MAF1	-5378
NEDD4	-5161
RPS27A	-5160
PPARG	-4993
SNAI1	-4869
PSMA4	-4415
TNRC6C	-4344
CBX6	-4267
MTOR	-4132
WWP2	-4057
LAMTOR5	-4024
PSMB6	-3827
SLC38A9	-3765
SUZ12	-3460
HDAC7	-3442
SNAI2	-3277
UBB	-3180
CHD3	-3019
AKT1	-2579
CBX2	-2535
LAMTOR3	-2457
PSMC2	-2444
AGO4	-2336
STUB1	-1865
PREX2	-488
NR2E1	-296
MECOM	741
MTA3	760
MTA2	1111
PSMD13	2181
RPTOR	3072
LAMTOR4	4242
PSME1	4473
PSMB8	4550
ATN1	4996
FRK	6014
PSMA3	6151
PTENP1	6502
LAMTOR2	7095
CSNK2B	7911
PSMB1	7962
TNRC6A	8504
PSMB9	9240
HDAC1	9635
PSMC5	9697
SCMH1	9961
PSMD4	10510
PSMC3	10621
PSMC4	10904
RRAGB	10973
RNF146	11134
UBA52	11501
MTA1	11808
PSMB7	11959
PSMD6	12288
TP53	12443
JUN	12501
PHC1	13482
RING1	13652
PSMB4	13901
PSMB10	13932
CBX8	14153
AKT2	14457
PSMB3	14498
EZH2	14588
SEM1	14859
PSME2	14893
MOV10	14934
MBD3	15002
SALL4	15440

---

Respiratory electron transport

Respiratory electron transport

	22
set	Respiratory electron transport
setSize	103
pANOVA	8.33e-07
s.dist	0.281
p.adjustANOVA	2.86e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NDUFA3	15362
NDUFB1	15346
NDUFA1	15253
NDUFV2	15224
COX5B	15219
MT-ND3	15179
NDUFS5	15132
NDUFAF3	15110
UQCRB	15101
MT-CYB	15081
MT-CO3	15080
NDUFA7	15075
COX6A1	15014
NDUFB8	14960
COX6B1	14948
COX7B	14899
MT-CO1	14828
COX4I1	14755
UQCRQ	14657
MT-CO2	14552

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NDUFA3	15362
NDUFB1	15346
NDUFA1	15253
NDUFV2	15224
COX5B	15219
MT-ND3	15179
NDUFS5	15132
NDUFAF3	15110
UQCRB	15101
MT-CYB	15081
MT-CO3	15080
NDUFA7	15075
COX6A1	15014
NDUFB8	14960
COX6B1	14948
COX7B	14899
MT-CO1	14828
COX4I1	14755
UQCRQ	14657
MT-CO2	14552
MT-ND2	14490
NDUFS8	14487
NDUFA13	14484
NDUFA2	14481
COX6C	14453
ACAD9	14402
NDUFA8	14321
NDUFB4	14290
MT-ND1	14264
MT-ND5	14139
MT-ND4	14079
MT-ND6	13969
NDUFA12	13944
NDUFA6	13790
NDUFS7	13575
NDUFA11	13563
NDUFS3	13204
UQCR10	13028
NDUFB10	12853
NDUFV3	12653
NDUFAF2	12597
NDUFB7	12482
NDUFS6	12427
NDUFAF6	12264
NDUFB2	12149
NDUFC1	12063
COX19	11950
NDUFB3	11906
COA1	11532
NDUFV1	11451
NDUFA5	11096
SURF1	10834
COQ10A	10498
NDUFB9	9766
COX7C	9745
ETFB	9673
NDUFA10	9639
NDUFAF5	9415
NDUFAF7	8918
NDUFB11	7425
UQCRH	6925
NDUFA9	6256
COX20	5997
ETFDH	239
UQCR11	224
ECSIT	-357
COX8A	-557
TMEM126B	-638
TMEM186	-1524
NDUFB6	-1580
TIMMDC1	-1624
NDUFAF1	-2299
NDUFAF4	-2437
NDUFA4	-3230
COX18	-3870
CYCS	-4372
TACO1	-4423
COX16	-4441
NDUFC2	-4456
COX11	-5188
COX14	-5346
UQCRC1	-5416
TRAP1	-5660
SCO2	-5829
CYC1	-5983
COX5A	-6065
NDUFS4	-6131
NUBPL	-6610
NDUFAB1	-7080
SDHD	-7213
SDHC	-7321
SDHB	-7529
NDUFS2	-7766
NDUFS1	-7990
COQ10B	-8309
NDUFB5	-8339
COX7A2L	-8777
ETFA	-8963
UQCRC2	-9158
SCO1	-9208
LRPPRC	-9513
SDHA	-10529
UQCRFS1	-10593

---

Phospholipid metabolism

Phospholipid metabolism

	17
set	Phospholipid metabolism
setSize	191
pANOVA	2.89e-10
s.dist	-0.264
p.adjustANOVA	1.74e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTMR12	-11203
LPIN2	-11124
PLEKHA2	-11094
PIK3CB	-10967
CSNK2A1	-10886
CPNE3	-10848
SBF2	-10744
RAB14	-10741
AGPAT5	-10683
SELENOI	-10527
MIGA1	-10354
CSNK2A2	-10253
MFSD2A	-10223
PI4KB	-10206
LCLAT1	-10039
RAB5A	-10034
PNPLA8	-9931
MTMR6	-9872
OSBPL8	-9833
PIKFYVE	-9788

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTMR12	-11203
LPIN2	-11124
PLEKHA2	-11094
PIK3CB	-10967
CSNK2A1	-10886
CPNE3	-10848
SBF2	-10744
RAB14	-10741
AGPAT5	-10683
SELENOI	-10527
MIGA1	-10354
CSNK2A2	-10253
MFSD2A	-10223
PI4KB	-10206
LCLAT1	-10039
RAB5A	-10034
PNPLA8	-9931
MTMR6	-9872
OSBPL8	-9833
PIKFYVE	-9788
PLEKHA1	-9722
GPAT3	-9666
PLA2G4A	-9665
PLEKHA5	-9514
PIK3R1	-9444
PIK3R4	-9423
PITPNB	-9355
AGPAT3	-9326
VAC14	-9302
MTMR2	-9253
PITPNM1	-9247
MBOAT2	-9176
ARF3	-9080
ARF1	-8976
PIK3CA	-8881
TNFAIP8L1	-8847
PNPLA3	-8784
DDHD2	-8766
PLEKHA8	-8576
HADHB	-8549
CEPT1	-8539
PIP4K2A	-8430
OSBPL10	-8314
PTDSS1	-8288
PI4K2A	-8161
DDHD1	-8145
PIK3C3	-8086
LPCAT2	-8072
CDIPT	-8055
MTMR4	-8019
INPP5F	-7989
MBOAT7	-7984
PIK3C2A	-7978
HADHA	-7967
GDE1	-7890
OCRL	-7866
MTMR9	-7864
CHPT1	-7836
INPP4A	-7786
PIP4K2C	-7769
STARD7	-7717
PIP5K1A	-7714
ETNK2	-7689
SLC44A1	-7527
SACM1L	-7515
PLA2G12A	-7470
GPD2	-7409
LPCAT1	-7363
PTEN	-7317
LPGAT1	-7314
MTMR3	-7248
PI4K2B	-7232
GPAM	-7211
CRLS1	-7198
PLEKHA3	-7192
LPIN1	-7178
AGPAT1	-7092
MTMR1	-6965
ABHD4	-6960
PCYT1A	-6929
PLD6	-6924
PLA2G15	-6658
PCTP	-6651
PIP5K1B	-6325
SYNJ1	-6310
MTM1	-6304
TNFAIP8	-6118
PLAAT1	-5967
CDS2	-5934
ETNK1	-5871
CDS1	-5865
MTMR10	-5507
PIK3R2	-5467
OSBPL5	-5363
PIK3R3	-5298
DGAT2	-5234
SBF1	-5103
SLC44A5	-5101
PLA2G5	-4904
PLD1	-4856
PISD	-4736
PGS1	-4652
MGLL	-4618
GPD1L	-4474
PNPLA2	-4213
SLC44A2	-4191
INPP5D	-4161
FIG4	-4129
RAB4A	-4025
PIK3CD	-3823
GNPAT	-3663
PIK3CG	-3556
PLD2	-3462
STARD10	-3378
GDPD1	-2995
GPAT4	-2898
LPCAT3	-2721
GDPD5	-2717
PIK3R5	-2536
LPCAT4	-2330
CHAT	-2306
PEMT	-1461
PIK3C2B	-976
PLA2G4F	-762
MTMR14	-241
PLA2G10	291
PLD3	414
MBOAT1	648
INPP5K	658
PITPNM3	1185
DGAT1	1629
TNFAIP8L3	1912
PIK3R6	2238
MTMR7	2433
BCHE	2903
ENPP6	3048
PLA2G4E	3748
SLC44A3	4289
PLA1A	4537
INPP4B	4559
TPTE2	5327
PIP5K1C	5703
PLA2G4D	5882
PLBD1	6594
PI4KA	7020
AGPAT2	7378
SLC44A4	7833
CSNK2B	7911
SYNJ2	7924
PNPLA6	8139
GPAT2	8303
ACHE	8779
PCYT1B	9025
LIPH	9606
PLD4	9661
PTPN13	9890
PTPMT1	10176
PLEKHA6	10266
LPIN3	10276
GPD1	11020
PHOSPHO1	11209
PTDSS2	11303
ABHD3	11513
PCYT2	12310
PLEKHA4	12588
AGK	12603
ACP6	12649
PLB1	12674
PLA2R1	12758
INPP5J	13004
PLAAT4	13035
PLA2G4C	13078
PIP4K2B	13190
INPP5E	13264
PITPNM2	13360
CPNE1	13631
GDPD3	13779
PNPLA7	13968
MIGA2	14096
TMEM86B	14145
AGPAT4	14316
RUFY1	14434
INPPL1	14521
GPCPD1	14781
CHKA	14946
PLAAT3	15007
CPNE7	15142
TAZ	15321
PLA2G6	15354
PLA2G4B	15399
CHKB	15429

---

Mitochondrial biogenesis

Mitochondrial biogenesis

	7
set	Mitochondrial biogenesis
setSize	91
pANOVA	0.000297
s.dist	-0.219
p.adjustANOVA	0.000713

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKAB2	-11148
IDH2	-11079
MED1	-11049
HELZ2	-10991
SOD2	-10857
PPARA	-10816
ALAS1	-10721
GLUD1	-10458
NCOA2	-10279
TFB2M	-10154
CALM1	-9971
PPARGC1B	-9825
APOOL	-9797
ATP5F1B	-9753
CREBBP	-9655
IMMT	-9498
SAMM50	-9305
MEF2D	-9170
MAPK14	-9054
TBL1XR1	-8937

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKAB2	-11148
IDH2	-11079
MED1	-11049
HELZ2	-10991
SOD2	-10857
PPARA	-10816
ALAS1	-10721
GLUD1	-10458
NCOA2	-10279
TFB2M	-10154
CALM1	-9971
PPARGC1B	-9825
APOOL	-9797
ATP5F1B	-9753
CREBBP	-9655
IMMT	-9498
SAMM50	-9305
MEF2D	-9170
MAPK14	-9054
TBL1XR1	-8937
PPRC1	-8736
TGS1	-8714
GABPA	-8583
ATP5F1A	-8575
ATF2	-8550
CHCHD3	-8528
PRKAG1	-8448
GABPB1	-8398
HCFC1	-8229
CREB1	-8171
TFAM	-7694
TBL1X	-7506
PRKAG2	-7476
ATP5PB	-7343
TMEM11	-7250
PRKAA2	-7203
CRTC3	-7132
NCOA6	-6993
CHD9	-6687
NR1D1	-6478
TFB1M	-6476
NCOA1	-6430
NRF1	-6410
HSPA9	-6368
CAMK4	-6360
RXRA	-6096
CARM1	-6020
HDAC3	-5788
PRKAB1	-5731
POLRMT	-5054
CHCHD6	-4944
CYCS	-4372
CRTC2	-3894
ATP5F1E	-3884
ATP5MC3	-3689
SIRT5	-1954
SIRT4	-1011
GLUD2	-879
PPARGC1A	368
DMAC2L	871
MEF2C	2785
ESRRA	3600
CRTC1	4717
ATP5PF	6886
NCOR1	7630
MTX2	8174
MTERF1	10067
SSBP1	11056
ATP5MC2	11283
POLG2	11894
ATP5F1C	11955
MICOS10	12049
APOO	12417
ATP5PO	12433
ATP5MC1	12566
MAPK11	12572
PERM1	13017
ATP5MG	13198
MTX1	13478
DNAJC11	13789
ACSS2	14227
MT-ATP6	14231
SIRT3	14544
MICOS13	14573
MAPK12	14603
MT-ATP8	14608
SMARCD3	14895
ATP5PD	14961
ATP5MF	14964
ATP5F1D	14966
ATP5ME	15355

---

Nervous system development

Nervous system development

	13
set	Nervous system development
setSize	529
pANOVA	5.2e-16
s.dist	-0.205
p.adjustANOVA	6.24e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB3	-11255
HMGCR	-11253
SEMA7A	-11237
ITGA5	-11230
SEMA5A	-11221
CLTC	-11168
CYP51A1	-11166
NUMB	-11163
GDNF	-11161
ITGB1	-11155
PSME4	-11141
NCK1	-11135
NRP2	-11097
SREBF2	-11089
MAP2K1	-11084
HSPA8	-11060
MAPK1	-10995
PIK3CB	-10967
GSPT1	-10953
MSN	-10950

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB3	-11255
HMGCR	-11253
SEMA7A	-11237
ITGA5	-11230
SEMA5A	-11221
CLTC	-11168
CYP51A1	-11166
NUMB	-11163
GDNF	-11161
ITGB1	-11155
PSME4	-11141
NCK1	-11135
NRP2	-11097
SREBF2	-11089
MAP2K1	-11084
HSPA8	-11060
MAPK1	-10995
PIK3CB	-10967
GSPT1	-10953
MSN	-10950
GRB2	-10928
MMP9	-10902
CSNK2A1	-10886
ITGA2	-10877
EFNB2	-10875
PABPC1	-10825
CAP1	-10794
L1CAM	-10775
SDCBP	-10738
PRKAR2A	-10708
SLIT2	-10674
SPTBN1	-10670
PSMD1	-10668
CD24	-10648
PAK1	-10640
GSK3B	-10632
ROCK1	-10626
RHOA	-10555
NTN1	-10544
EGFR	-10531
YES1	-10514
DAG1	-10504
PFN2	-10478
NGEF	-10476
RGMB	-10462
PSEN1	-10420
LAMC1	-10419
ETF1	-10413
DLG1	-10391
RPS6KA3	-10363
AP2B1	-10323
VLDLR	-10314
PSMD2	-10307
ABL2	-10285
CSNK2A2	-10253
PRNP	-10234
PMP22	-10228
SCD5	-10201
SIAH2	-10194
PAK2	-10191
ITGAV	-10173
MYO10	-10169
ARPC2	-10166
TLN1	-10092
AP2A1	-10088
HSP90AB1	-10084
RANBP9	-10075
ALCAM	-10029
CASC3	-9953
GPC1	-9946
HSP90AA1	-9945
NCBP2	-9912
RPL39L	-9883
CUL2	-9882
EIF4G1	-9877
LAMA1	-9870
EPHA4	-9853
ACTR2	-9795
MYH9	-9794
RDX	-9760
EZR	-9750
APH1A	-9723
ACTR3	-9710
IRS2	-9705
PSMD3	-9689
PSMA7	-9678
DLG4	-9677
MET	-9674
PTPN11	-9660
WWTR1	-9598
DOCK1	-9584
PSMD11	-9552
ADAM10	-9546
CDC42	-9527
EPHB1	-9524
ANK3	-9518
EFNB1	-9500
RELN	-9494
TEAD1	-9483
FLRT3	-9479
PIK3R1	-9444
USP33	-9348
SEMA3A	-9340
PAK4	-9314
WASL	-9298
UNC5B	-9296
NRAS	-9293
EIF4A3	-9219
ARPC1B	-9211
RHOC	-9122
FRS2	-9097
ARPC5	-9087
GAB2	-9072
MAPK14	-9054
ARHGAP35	-9042
NCK2	-8988
MYH10	-8978
EPHB4	-8958
YAP1	-8955
MAPK3	-8949
PSMD7	-8924
PSMD5	-8901
RNPS1	-8883
PIK3CA	-8881
SOS1	-8846
PSMD8	-8841
RASA1	-8801
NRP1	-8764
ACTG1	-8669
RPL10A	-8562
HDAC2	-8521
PSMF1	-8503
DPYSL3	-8451
ARHGEF12	-8447
CLTA	-8412
PSMA5	-8382
RAC1	-8358
PPP3CB	-8357
PITPNA	-8332
ENAH	-8245
PRKACB	-8206
CREB1	-8171
EFNA5	-8124
PSMC1	-8097
SDC2	-8067
PSMA2	-8025
PSME3	-7994
NCBP1	-7992
PTK2	-7917
SRC	-7851
SH3KBP1	-7843
PSMB5	-7716
SMARCA4	-7700
SHANK3	-7668
EFNB3	-7657
DOK1	-7645
UNC5D	-7630
RPL7	-7545
NEO1	-7538
EPHB2	-7429
PSMD14	-7340
NTN4	-7320
SRGAP1	-7316
SLIT3	-7273
AGRN	-7222
ITSN1	-7210
KRAS	-7194
SOS2	-7183
VAV2	-7167
VASP	-7162
ROBO1	-7141
RPL41	-7130
DNM2	-7104
RPS5	-7102
FYN	-7099
KIF4A	-7081
PSMD10	-7034
PSMA6	-6980
GAB1	-6967
UBC	-6964
CACNA1H	-6936
SHC3	-6917
PSMC6	-6903
RPS6KA5	-6900
SPTAN1	-6870
RPLP0	-6852
ST8SIA4	-6843
SEMA6D	-6835
EGR2	-6824
GRB10	-6784
DPYSL2	-6754
PSMD9	-6748
KALRN	-6738
PFN1	-6699
COL6A2	-6692
GSPT2	-6662
PRX	-6661
CDK5R1	-6579
UTRN	-6545
NELL2	-6532
APH1B	-6506
EPHA2	-6477
UPF2	-6463
UNC5A	-6375
ITGA9	-6351
PLXNA4	-6344
RPS6KA2	-6326
CXCL12	-6285
DCC	-6255
RPS6KA1	-6227
MYL6	-6189
ARPC1A	-6147
CAP2	-6127
PSMB2	-6126
RPL3	-6101
PSMA1	-6072
MYL12A	-6023
CXCR4	-5971
MAPK8	-5956
SHC1	-5939
RPL23A	-5925
NRCAM	-5814
AP2S1	-5809
ISL1	-5799
CNTN1	-5769
VAV3	-5761
RPS3A	-5741
COL6A1	-5738
PSMD12	-5542
ROCK2	-5525
PRKCA	-5486
RPL21	-5480
PIK3R2	-5467
DOK4	-5447
RPS29	-5438
LHX2	-5386
LHX4	-5369
PIK3R3	-5298
KCNQ3	-5273
AP2M1	-5191
RPL13A	-5167
RPS27A	-5160
COL6A3	-5109
SCN5A	-5013
SPTBN2	-5008
NAB1	-4923
CLTCL1	-4876
ARHGEF28	-4827
SEMA6A	-4721
CACNB4	-4720
COL4A4	-4697
PLXNC1	-4591
PAK3	-4574
GRB7	-4477
ARPC4	-4436
GRIN2B	-4425
PSMA4	-4415
TRPC1	-4339
SHTN1	-4322
DOK6	-4254
SH3GL2	-4168
SEMA4D	-4139
ADGRG6	-4087
SIAH1	-3993
MMP2	-3976
RPL10	-3951
EPHB6	-3880
EFNA2	-3867
RGMA	-3839
PSMB6	-3827
PIK3CD	-3823
ABL1	-3786
AP2A2	-3784
CLASP2	-3775
ERBB2	-3735
PLXND1	-3674
DPYSL4	-3578
ITGA1	-3561
MYH14	-3546
MAPK7	-3522
LAMA2	-3441
RBM8A	-3271
MBP	-3263
EFNA3	-3185
UBB	-3180
RPS12	-3070
POU3F2	-3068
GFRA2	-3061
PTPRA	-3039
DNM3	-3014
CFL1	-3006
FGFR1	-2958
ABLIM1	-2915
EFNA1	-2890
GIT1	-2835
PLXNA1	-2714
CNTN6	-2620
EFNA4	-2600
RPS27	-2527
NAB2	-2521
LYN	-2496
LHX9	-2470
PSMC2	-2444
EPHA5	-2175
NCAM1	-2110
PSPN	-2091
PTPRC	-1946
LAMB1	-1937
DPYSL5	-1813
MAP2K2	-1778
RPS9	-1595
SPTBN4	-1381
RPL22	-1380
PAK5	-1369
DOK5	-1348
TRPC3	-1248
RPS2	-1189
ABLIM3	-999
EPHA8	-992
EPHA6	-991
ARHGAP39	-957
RPL30	-868
ROBO2	-663
MYL12B	-648
SLIT1	-570
AKAP5	-305
PRKCQ	-43
CNTN2	-23
NFASC	246
CACNB3	260
RPL22L1	317
SCN7A	402
ABLIM2	542
LIMK2	785
LYPLA2	900
RPL18A	1090
PRKACA	1217
RPSA	1280
ST8SIA2	1353
TRPC5	1449
EPHA10	1483
SCN2B	1646
COL4A2	1908
PSMD13	2181
GFRA1	2416
CACNA1I	2495
UNC5C	2532
TRPC4	2547
SCN3A	2589
SCN3B	2993
RPS17	3103
NCAN	3166
RPS6KA6	3464
RPS10	3602
RPS3	3800
MYO9B	4029
DAB1	4290
PSME1	4473
RND1	4480
RPL27	4534
PSMB8	4550
ZSWIM8	4553
COL9A1	4634
RPS23	4723
RET	4877
ELOC	4912
COL6A6	4932
FES	4954
NCSTN	5056
MYH11	5313
RPL7A	5578
SCN1B	5613
PIP5K1C	5703
PAK6	5967
PSMA3	6151
RAP1GAP	6176
SCN1A	6337
RPL8	6573
COL4A1	6638
RRAS	6705
EPHB3	6769
RPL39	6918
SCN9A	6941
GRIN1	6967
RPL15	7111
SCN2A	7153
MSI1	7215
RPS13	7670
SRGAP2	7889
CSNK2B	7911
GAP43	7936
PSMB1	7962
CACNA1G	8035
POU3F1	8093
EPHA1	8109
TIAM1	8502
COL4A3	8534
SCN4B	8741
EPHA7	8936
CRMP1	9105
PSMB9	9240
DLG3	9269
SRGAP3	9312
ITGA2B	9389
TRIO	9456
CACNA1C	9657
ANK2	9663
PSMC5	9697
RPS6	9808
SCN8A	9858
NRTN	9877
RPL3L	10061
SPTBN5	10108
PLXNB3	10320
ACTB	10405
PSMD4	10510
RPL26	10563
SEMA4A	10600
PSMC3	10621
MAGOHB	10706
RPL26L1	10754
RPL5	10785
PSMC4	10904
CLTB	10983
RPL36AL	11075
RPS25	11123
COL6A5	11161
RPS11	11194
RPS8	11338
ANK1	11361
RHOB	11375
ADGRV1	11426
UBA52	11501
ARTN	11520
DRP2	11554
RPS6KA4	11605
AGAP2	11841
ARPC3	11954
PSMB7	11959
RPS19	12039
RPL35A	12114
PSMD6	12288
CACNA1S	12315
ARHGEF11	12428
RPS14	12432
RPS4X	12510
ARHGEF7	12558
MAPK11	12572
CD72	12596
SCN11A	12693
RPL37A	12745
RPL6	12805
CLASP1	12846
DSCAML1	13065
COL9A3	13079
KCNQ2	13081
LDB1	13109
LIMK1	13121
CDK5	13134
SPTB	13307
RPL11	13315
PLXNA2	13318
RPS15A	13339
RPS28	13379
RPS7	13381
UPF3B	13412
MYL9	13581
RPLP1	13585
RPS16	13615
EVL	13632
RPL36	13703
UPF3A	13738
CACNB2	13741
RPL13	13761
RPL4	13766
PSEN2	13810
RPS20	13888
PSMB4	13901
RPS21	13924
RPS18	13929
PSMB10	13932
MAGOH	13939
RPS24	13945
RPL9	14000
PLXNA3	14001
ROBO3	14011
RPLP2	14036
RPS27L	14115
RPL17	14216
RPL32	14237
RPL19	14317
RPL29	14344
PSENEN	14361
MAPK13	14364
CACNA1D	14372
RPL24	14403
RPL12	14435
RBX1	14438
RPL27A	14452
PSMB3	14498
RPL23	14502
MAPK12	14603
RPL31	14644
RPL34	14680
RPL28	14692
FAU	14693
RPL18	14701
RPS15	14717
RPL35	14750
CNTNAP1	14774
ELOB	14784
ITGA10	14841
SEM1	14859
HRAS	14873
PDLIM7	14880
PSME2	14893
RPL14	14922
RPL36A	14937
COL4A5	14952
CACNB1	14981
RPS26	14986
HOXA2	15073
RPL37	15167
RPL38	15198
PLXNB1	15332
PLCG1	15349
DNM1	15392
FARP2	15405
COL9A2	15448

---

Gene Silencing by RNA

Gene Silencing by RNA

	4
set	Gene Silencing by RNA
setSize	98
pANOVA	0.000725
s.dist	-0.197
p.adjustANOVA	0.00158

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	-11176
NUP155	-10994
NUP153	-10883
NUP58	-10844
NUP98	-10785
AGO2	-10781
SEC13	-10720
POLR2B	-10686
TDRKH	-10381
NUP160	-10300
NDC1	-10127
PRKRA	-10094
HSP90AA1	-9945
IPO8	-9691
NUP93	-9551
AGO3	-9480
NUP54	-9324
POLR2C	-9317
RANBP2	-9304
NUP88	-8874

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	-11176.0
NUP155	-10994.0
NUP153	-10883.0
NUP58	-10844.0
NUP98	-10785.0
AGO2	-10781.0
SEC13	-10720.0
POLR2B	-10686.0
TDRKH	-10381.0
NUP160	-10300.0
NDC1	-10127.0
PRKRA	-10094.0
HSP90AA1	-9945.0
IPO8	-9691.0
NUP93	-9551.0
AGO3	-9480.0
NUP54	-9324.0
POLR2C	-9317.0
RANBP2	-9304.0
NUP88	-8874.0
NUP205	-8613.0
TNRC6B	-8468.0
NUP188	-8440.0
RAE1	-8434.0
XPO5	-8323.0
POM121	-8211.0
NUP133	-7859.0
SEH1L	-7750.0
DICER1	-7413.0
POM121C	-7209.0
H2BC12	-6930.0
PLD6	-6924.0
RAN	-6907.0
TSN	-6893.0
NUP214	-6714.0
POLR2E	-6473.0
H2AC6	-6335.0
TSNAX	-6132.0
H2BC15	-5864.0
POLR2D	-5589.0
AGO1	-5490.0
ANG	-5475.0
NUP50	-5376.0
NUP35	-5266.0
NUP62	-5048.0
NUP37	-4886.0
POLR2G	-4842.0
TPR	-4678.0
H2AZ1	-4575.0
H2AZ2	-4512.0
TNRC6C	-4344.0
PIWIL4	-4170.0
H2BC11	-3690.0
H2BC4	-2910.0
NUP43	-2776.0
ELAC2	-2767.0
AGO4	-2336.0
PIWIL1	-1014.0
H2BC21	-842.0
H3C1	-256.0
MYBL1	1102.0
ASZ1	1977.0
H2AC7	3036.0
H2AC14	4154.0
H2AC18	4162.0
H2BC13	4722.0
H2AB1	5129.0
FKBP6	5250.0
H3C15	6817.5
POLR2K	7902.0
H2BU1	7954.0
TDRD6	8145.0
TDRD12	8275.0
TARBP2	8401.0
H2BC9	8423.0
TNRC6A	8504.0
BCDIN3D	8541.0
TDRD9	8891.0
H2BC17	9581.0
NUP85	10330.0
HENMT1	10788.0
DDX4	11332.0
NUP42	11356.0
NUP210	12037.0
POLR2L	12266.0
POLR2F	12718.0
DROSHA	13189.0
H2AC20	13219.0
H3-3A	13435.0
PIWIL2	13567.0
H2BC5	13682.0
POLR2H	14099.0
H2AJ	14158.0
POLR2I	14228.0
AAAS	14527.0
NUP107	14769.0
POLR2J	15117.0
DGCR8	15124.0

---

Resolution of D-Loop Structures

Resolution of D-Loop Structures

	21
set	Resolution of D-Loop Structures
setSize	33
pANOVA	0.0625
s.dist	0.187
p.adjustANOVA	0.079

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLX1A	15366
XRCC3	15046
EME1	14767
MUS81	14711
DNA2	14674
RTEL1	14652
EME2	14351
BLM	14238
MRE11	13301
GEN1	13208
XRCC2	11884
RAD51D	11280
SLX4	10035
ATM	8942
RAD51C	8931
RMI2	8742
EXO1	6676
BRCA1	6087
BRIP1	4013
SPIDR	-239

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLX1A	15366
XRCC3	15046
EME1	14767
MUS81	14711
DNA2	14674
RTEL1	14652
EME2	14351
BLM	14238
MRE11	13301
GEN1	13208
XRCC2	11884
RAD51D	11280
SLX4	10035
ATM	8942
RAD51C	8931
RMI2	8742
EXO1	6676
BRCA1	6087
BRIP1	4013
SPIDR	-239
RAD51AP1	-2291
RAD51B	-3226
RAD51	-4466
BRCA2	-4733
KAT5	-4753
RBBP8	-5253
RMI1	-5287
RAD50	-5803
WRN	-5891
PALB2	-5980
NBN	-6976
BARD1	-7173
TOP3A	-7347

---

Stabilization of p53

Stabilization of p53

	24
set	Stabilization of p53
setSize	53
pANOVA	0.036
s.dist	-0.166
p.adjustANOVA	0.0516

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSME4	-11141
PSMD1	-10668
PSMD2	-10307
PHF20	-9866
PSMD3	-9689
PSMA7	-9678
PSMD11	-9552
PSMD7	-8924
PSMD5	-8901
PSMD8	-8841
PSMF1	-8503
PSMA5	-8382
MDM2	-8172
PSMC1	-8097
PSMA2	-8025
PSME3	-7994
PSMB5	-7716
PSMD14	-7340
PSMD10	-7034
PSMA6	-6980

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSME4	-11141
PSMD1	-10668
PSMD2	-10307
PHF20	-9866
PSMD3	-9689
PSMA7	-9678
PSMD11	-9552
PSMD7	-8924
PSMD5	-8901
PSMD8	-8841
PSMF1	-8503
PSMA5	-8382
MDM2	-8172
PSMC1	-8097
PSMA2	-8025
PSME3	-7994
PSMB5	-7716
PSMD14	-7340
PSMD10	-7034
PSMA6	-6980
UBC	-6964
PSMC6	-6903
PSMD9	-6748
PSMB2	-6126
PSMA1	-6072
PSMD12	-5542
RPS27A	-5160
PSMA4	-4415
PSMB6	-3827
UBB	-3180
PSMC2	-2444
PSMD13	2181
PSME1	4473
PSMB8	4550
PSMA3	6151
CHEK2	7769
PSMB1	7962
ATM	8942
PSMB9	9240
PSMC5	9697
PSMD4	10510
PSMC3	10621
PSMC4	10904
UBA52	11501
PSMB7	11959
PSMD6	12288
TP53	12443
MDM4	12935
PSMB4	13901
PSMB10	13932
PSMB3	14498
SEM1	14859
PSME2	14893

---

Cellular response to starvation

Cellular response to starvation

	1
set	Cellular response to starvation
setSize	150
pANOVA	0.00171
s.dist	0.148
p.adjustANOVA	0.00343

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ASNS	15423
RPL38	15198
RPL37	15167
RPS26	14986
ATP6V1B1	14965
ITFG2	14955
RPL36A	14937
RPL14	14922
WDR59	14783
RPL35	14750
RPS15	14717
RPL18	14701
FAU	14693
RPL28	14692
RPL34	14680
RPL31	14644
TCIRG1	14533
RPL23	14502
RPL27A	14452
RPL12	14435

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ASNS	15423
RPL38	15198
RPL37	15167
RPS26	14986
ATP6V1B1	14965
ITFG2	14955
RPL36A	14937
RPL14	14922
WDR59	14783
RPL35	14750
RPS15	14717
RPL18	14701
FAU	14693
RPL28	14692
RPL34	14680
RPL31	14644
TCIRG1	14533
RPL23	14502
RPL27A	14452
RPL12	14435
RPL24	14403
RPL29	14344
ATF4	14323
RPL19	14317
RPL32	14237
RPL17	14216
SZT2	14180
RPS27L	14115
RPLP2	14036
RPL9	14000
RPS24	13945
RPS18	13929
RPS21	13924
RPS20	13888
RPL4	13766
RPL13	13761
RPL36	13703
RPS16	13615
RPLP1	13585
RPS7	13381
RPS28	13379
RPS15A	13339
RPL11	13315
ATP6V0E1	13268
KPTN	13057
NPRL2	13055
ATP6V1F	13041
RPL6	12805
RPL37A	12745
RPS4X	12510
ATP6V0E2	12441
RPS14	12432
RPL35A	12114
RPS19	12039
UBA52	11501
RPS8	11338
RPS11	11194
RPS25	11123
RPL36AL	11075
RRAGB	10973
RPL5	10785
RPL26L1	10754
RPL26	10563
DEPDC5	10323
RPL3L	10061
RPS6	9808
CEBPB	8789
ATP6V1C2	8185
RPS13	7670
RPL15	7111
LAMTOR2	7095
RPL39	6918
ATP6V1G1	6695
RPL8	6573
RPL7A	5578
RPS23	4723
ATP6V1G2	4655
RPL27	4534
DDIT3	4244
LAMTOR4	4242
NPRL3	4222
RPS3	3800
RPS10	3602
RPS17	3103
RPTOR	3072
ATP6V1E2	2271
RPSA	1280
RPL18A	1090
RPL22L1	317
RPL30	-868
RPS2	-1189
RPL22	-1380
RPS9	-1595
LAMTOR3	-2457
RPS27	-2527
RPS12	-3070
CEBPG	-3258
ATP6V0B	-3530
SESN1	-3586
ATP6V0D2	-3721
SLC38A9	-3765
RPL10	-3951
LAMTOR5	-4024
SESN2	-4053
GCN1	-4111
MTOR	-4132
ATP6V1H	-4305
FLCN	-4787
RPS27A	-5160
RPL13A	-5167
RPS29	-5438
RPL21	-5480
ATP6V0C	-5626
ATF3	-5678
RPS3A	-5741
MLST8	-5916
RPL23A	-5925
ATP6V1E1	-5987
RPL3	-6101
ATP6V1D	-6336
TRIB3	-6551
RPLP0	-6852
EIF2AK4	-6935
ATP6V0D1	-7022
RPS5	-7102
RPL41	-7130
IMPACT	-7160
EIF2S3	-7426
RPL7	-7545
RHEB	-7617
SEH1L	-7750
RRAGA	-7858
ATP6V1C1	-8108
WDR24	-8419
ATF2	-8550
RPL10A	-8562
BMT2	-8696
LAMTOR1	-8761
ATP6V1A	-8769
FNIP2	-8907
FNIP1	-9025
EIF2S2	-9281
MIOS	-9516
ATP6V1B2	-9630
RPL39L	-9883
EIF2S1	-10388
RRAGD	-10673
SEC13	-10720
RRAGC	-10870
SH3BP4	-11045

---

Oxidative Stress Induced Senescence

Oxidative Stress Induced Senescence

	15
set	Oxidative Stress Induced Senescence
setSize	83
pANOVA	0.0365
s.dist	-0.133
p.adjustANOVA	0.0516

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	-10995
RNF2	-10434
MAPKAPK3	-10112
CDK6	-9998
PHC3	-9669
MAP2K4	-9503
AGO3	-9480
MAPK14	-9054
BMI1	-9016
MAPK3	-8949
TNRC6B	-8468
PHC2	-8445
MAPKAPK2	-8275
MDM2	-8172
TFDP1	-7656
MAP4K4	-7610
EED	-7597
CBX4	-7569
CDKN2C	-7461
RBBP7	-7306

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	-10995.0
RNF2	-10434.0
MAPKAPK3	-10112.0
CDK6	-9998.0
PHC3	-9669.0
MAP2K4	-9503.0
AGO3	-9480.0
MAPK14	-9054.0
BMI1	-9016.0
MAPK3	-8949.0
TNRC6B	-8468.0
PHC2	-8445.0
MAPKAPK2	-8275.0
MDM2	-8172.0
TFDP1	-7656.0
MAP4K4	-7610.0
EED	-7597.0
CBX4	-7569.0
CDKN2C	-7461.0
RBBP7	-7306.0
RBBP4	-7153.0
UBC	-6964.0
H2BC12	-6930.0
MAP2K7	-6863.0
CDKN2D	-6701.0
H2AC6	-6335.0
MAPK8	-5956.0
KDM6B	-5903.0
H2BC15	-5864.0
MAP3K5	-5801.0
TNIK	-5554.0
AGO1	-5490.0
RPS27A	-5160.0
MAPK9	-5081.0
MAPKAPK5	-5025.0
MAP2K3	-4885.0
H2AZ1	-4575.0
H2AZ2	-4512.0
TNRC6C	-4344.0
CBX6	-4267.0
MINK1	-3744.0
H2BC11	-3690.0
SUZ12	-3460.0
UBB	-3180.0
H2BC4	-2910.0
CBX2	-2535.0
AGO4	-2336.0
TFDP2	-1493.0
H2BC21	-842.0
CDK4	-794.0
H3C1	-256.0
H2AC7	3036.0
H2AC14	4154.0
H2AC18	4162.0
H2BC13	4722.0
H2AB1	5129.0
H3C15	6817.5
E2F3	7330.0
H2BU1	7954.0
H2BC9	8423.0
TNRC6A	8504.0
FOS	8525.0
MAPK10	8829.0
H2BC17	9581.0
SCMH1	9961.0
UBA52	11501.0
TP53	12443.0
JUN	12501.0
MAPK11	12572.0
MAP2K6	12724.0
MDM4	12935.0
H2AC20	13219.0
H3-3A	13435.0
PHC1	13482.0
E2F2	13592.0
RING1	13652.0
H2BC5	13682.0
CBX8	14153.0
H2AJ	14158.0
EZH2	14588.0
MOV10	14934.0
E2F1	15100.0
TXN	15133.0

---

Metabolism

Metabolism

	5
set	Metabolism
setSize	1899
pANOVA	2.72e-18
s.dist	-0.12
p.adjustANOVA	6.54e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SEC24D	-11280
INSIG1	-11275
ITPR1	-11274
OSBP	-11258
HMGCR	-11253
ODC1	-11252
SQLE	-11242
SEC23A	-11227
IQGAP1	-11223
HAS2	-11222
MSMO1	-11213
MTMR12	-11203
SLC2A3	-11186
HMGCS1	-11180
ARG2	-11178
NCOA3	-11175
CYP51A1	-11166
PRKAB2	-11148
SEC24A	-11144
SERINC3	-11143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SEC24D	-11280.0
INSIG1	-11275.0
ITPR1	-11274.0
OSBP	-11258.0
HMGCR	-11253.0
ODC1	-11252.0
SQLE	-11242.0
SEC23A	-11227.0
IQGAP1	-11223.0
HAS2	-11222.0
MSMO1	-11213.0
MTMR12	-11203.0
SLC2A3	-11186.0
HMGCS1	-11180.0
ARG2	-11178.0
NCOA3	-11175.0
CYP51A1	-11166.0
PRKAB2	-11148.0
SEC24A	-11144.0
SERINC3	-11143.0
PSME4	-11141.0
LDLR	-11134.0
CERS6	-11133.0
LRP12	-11127.0
LPIN2	-11124.0
HK2	-11116.0
IDI1	-11106.0
PGM1	-11099.0
PLEKHA2	-11094.0
SREBF2	-11089.0
IDH2	-11079.0
MED1	-11049.0
HACD3	-11029.0
PPP2R5D	-11026.0
TPST2	-11025.0
FDFT1	-11018.0
DHCR24	-11017.0
GNB1	-11007.0
NUP155	-10994.0
HELZ2	-10991.0
GNG12	-10990.0
SERINC1	-10969.0
PIK3CB	-10967.0
TXNRD1	-10954.0
HK1	-10944.0
CERS2	-10941.0
PNP	-10927.0
B4GALT1	-10921.0
ADIPOR2	-10920.0
HS3ST3B1	-10917.0
PGM2	-10914.0
AMD1	-10911.0
PTGS2	-10907.0
PTGES3	-10887.0
CSNK2A1	-10886.0
NUP153	-10883.0
CSPG4	-10879.0
SC5D	-10873.0
CEMIP	-10868.0
LRP10	-10867.0
GART	-10865.0
ESYT1	-10864.0
DHCR7	-10855.0
CPNE3	-10848.0
ME2	-10846.0
NUP58	-10844.0
GNS	-10843.0
PFKFB3	-10831.0
PPARA	-10816.0
UGDH	-10813.0
GK	-10806.0
PPP2CB	-10791.0
CRYL1	-10790.0
NUP98	-10785.0
SLC16A1	-10783.0
KDSR	-10780.0
PLIN3	-10774.0
PPAT	-10764.0
GPC6	-10762.0
CPOX	-10760.0
LYPLA1	-10754.0
CHST2	-10747.0
SBF2	-10744.0
PGK1	-10743.0
RAB14	-10741.0
ALAS1	-10721.0
SEC13	-10720.0
FADS1	-10715.0
PRKAR2A	-10708.0
NFYA	-10704.0
PDK1	-10697.0
ALDH18A1	-10684.0
AGPAT5	-10683.0
LPL	-10681.0
SRD5A3	-10675.0
PSMD1	-10668.0
XYLT1	-10667.0
PFKP	-10661.0
ARNT	-10656.0
GNA11	-10651.0
SEC24B	-10646.0
ALDOC	-10628.0
HS2ST1	-10614.0
SERINC5	-10612.0
CS	-10604.0
CHSY1	-10602.0
GLCE	-10599.0
CERT1	-10597.0
UQCRFS1	-10593.0
NAMPT	-10590.0
SDC4	-10589.0
ACLY	-10569.0
PPP1CC	-10566.0
SPTLC2	-10552.0
HS3ST3A1	-10550.0
CSGALNACT2	-10541.0
SDHA	-10529.0
SELENOI	-10527.0
SPHK1	-10525.0
MED13	-10520.0
ACSL3	-10501.0
STXBP1	-10500.0
ABHD10	-10494.0
SGMS1	-10479.0
CAV1	-10469.0
GLUD1	-10458.0
PRSS3	-10451.0
HSD17B12	-10442.0
SORD	-10414.0
ACSL1	-10408.0
CAD	-10359.0
PAPSS2	-10357.0
MIGA1	-10354.0
DCK	-10347.0
SLC2A1	-10333.0
B4GALT3	-10332.0
TNFRSF21	-10321.0
PGAM1	-10317.0
SEC24C	-10311.0
GPC4	-10309.0
PSMD2	-10307.0
SPTLC1	-10305.0
NUP160	-10300.0
GNB4	-10287.0
PLPP3	-10286.0
NCOA2	-10279.0
CDK8	-10267.0
CSNK2A2	-10253.0
PRPS1	-10249.0
MED14	-10247.0
SUCLG2	-10244.0
ADCY3	-10243.0
B3GNT2	-10239.0
MFSD2A	-10223.0
EPRS1	-10220.0
PYCR1	-10208.0
PI4KB	-10206.0
GCLM	-10204.0
AHCYL1	-10203.0
SCD5	-10201.0
SCD	-10199.0
CYP1B1	-10198.0
VKORC1L1	-10189.0
HACD2	-10188.0
SAMD8	-10181.0
GNAI1	-10149.0
CRAT	-10144.0
NDC1	-10127.0
MTF1	-10117.0
ELOVL5	-10097.0
VAPA	-10085.0
HSP90AB1	-10084.0
ACSL4	-10082.0
ALDH6A1	-10077.0
GPHN	-10071.0
NDST1	-10070.0
PGM2L1	-10063.0
CPT2	-10046.0
LCLAT1	-10039.0
RAB5A	-10034.0
MMADHC	-10030.0
CD44	-10028.0
PSAP	-10012.0
GBE1	-10009.0
PAICS	-10007.0
DSE	-9978.0
CALM1	-9971.0
MDH2	-9964.0
SP1	-9960.0
AZIN1	-9949.0
GPC1	-9946.0
HSP90AA1	-9945.0
DHTKD1	-9940.0
NEU3	-9937.0
ACAN	-9936.0
PNPLA8	-9931.0
ACAT2	-9917.0
BCKDHA	-9911.0
PRKD3	-9895.0
RPL39L	-9883.0
LDHA	-9876.0
MTMR6	-9872.0
FUT4	-9867.0
UGP2	-9855.0
ECI2	-9845.0
OSBPL8	-9833.0
PPP2CA	-9827.0
PPARGC1B	-9825.0
PPM1L	-9812.0
KPNB1	-9790.0
ITPR2	-9789.0
PIKFYVE	-9788.0
PCCB	-9780.0
L2HGDH	-9769.0
ATP5F1B	-9753.0
COX15	-9746.0
BPNT2	-9745.0
LGMN	-9740.0
PYGL	-9739.0
PRKD2	-9727.0
PLEKHA1	-9722.0
GLB1	-9697.0
PSMD3	-9689.0
PSMA7	-9678.0
GPAT3	-9666.0
PLA2G4A	-9665.0
CREBBP	-9655.0
CHST3	-9649.0
UGCG	-9645.0
FASN	-9635.0
ENTPD7	-9634.0
ACOT7	-9632.0
ELOVL1	-9620.0
TPST1	-9606.0
PRKAR1A	-9591.0
GMPS	-9558.0
CMPK1	-9555.0
PSMD11	-9552.0
NUP93	-9551.0
OGDH	-9550.0
EP300	-9548.0
PLEKHA5	-9514.0
LRPPRC	-9513.0
SLC25A32	-9471.0
PIK3R1	-9444.0
STARD4	-9434.0
PIK3R4	-9423.0
BPGM	-9421.0
SIN3A	-9418.0
DLD	-9398.0
MAT2B	-9390.0
MARCKS	-9388.0
NUDT3	-9380.0
RETSAT	-9366.0
PITPNB	-9355.0
IMPA2	-9350.0
DLAT	-9330.0
AGPAT3	-9326.0
NUP54	-9324.0
MED13L	-9315.0
RANBP2	-9304.0
VAC14	-9302.0
WASL	-9298.0
CES2	-9289.0
ADCY1	-9284.0
RRM1	-9282.0
PPP1CB	-9269.0
ITPKC	-9263.0
NUDT11	-9261.0
CLOCK	-9260.0
DLST	-9257.0
MTMR2	-9253.0
PITPNM1	-9247.0
PRPS2	-9241.0
ADCY9	-9227.0
ADCY7	-9218.0
ACBD5	-9209.0
SCO1	-9208.0
NT5E	-9203.0
SLC19A2	-9202.0
CA9	-9179.0
MBOAT2	-9176.0
UQCRC2	-9158.0
MBTPS2	-9157.0
ADK	-9138.0
RARS1	-9117.0
PFKL	-9111.0
LBR	-9107.0
ARF3	-9080.0
ABCB7	-9063.0
SLC35B2	-9026.0
ADA	-8981.0
ARF1	-8976.0
COX10	-8973.0
CCNC	-8971.0
FADS2	-8969.0
ETFA	-8963.0
TBL1XR1	-8937.0
NDST2	-8936.0
KYAT3	-8927.0
PSMD7	-8924.0
NUDT4	-8910.0
PSMD5	-8901.0
ADIPOR1	-8887.0
SLC25A15	-8886.0
CHSY3	-8884.0
PIK3CA	-8881.0
SLC36A4	-8876.0
NUP88	-8874.0
TPI1	-8863.0
LRP8	-8860.0
MTHFD2	-8854.0
ARNT2	-8848.0
TNFAIP8L1	-8847.0
PSMD8	-8841.0
IMPDH2	-8822.0
PKM	-8819.0
SGPP1	-8812.0
AKR7A2	-8796.0
EHHADH	-8793.0
MMUT	-8791.0
PNPLA3	-8784.0
PDHX	-8778.0
COX7A2L	-8777.0
DDHD2	-8766.0
GNB2	-8753.0
NAT8L	-8752.0
STARD3NL	-8741.0
CHP1	-8720.0
HS6ST1	-8715.0
TGS1	-8714.0
MED8	-8708.0
SLC26A2	-8697.0
AK4	-8686.0
CHST6	-8682.0
SLC52A2	-8677.0
RRM2	-8672.0
MED21	-8662.0
RDH11	-8656.0
ETHE1	-8655.0
PDXK	-8630.0
NUP205	-8613.0
PANK3	-8599.0
IP6K1	-8595.0
B4GALT6	-8593.0
PLEKHA8	-8576.0
ATP5F1A	-8575.0
VAPB	-8567.0
RPL10A	-8562.0
HADHB	-8549.0
CEPT1	-8539.0
ENO1	-8532.0
DBT	-8524.0
OSBPL9	-8512.0
PSMF1	-8503.0
CARNMT1	-8486.0
CHST11	-8474.0
ENTPD3	-8462.0
LMBRD1	-8457.0
PPM1K	-8452.0
ADO	-8442.0
NUP188	-8440.0
RAE1	-8434.0
PIP4K2A	-8430.0
IDS	-8425.0
SMS	-8421.0
ALDH9A1	-8415.0
GPI	-8411.0
ARSJ	-8397.0
PSMA5	-8382.0
BCAT1	-8374.0
DCTD	-8373.0
MTR	-8361.0
NDUFB5	-8339.0
ALDOA	-8329.0
GYS1	-8322.0
OSBPL10	-8314.0
COQ10B	-8309.0
RORA	-8304.0
PTDSS1	-8288.0
ACAA2	-8281.0
MAPKAPK2	-8275.0
NT5C3A	-8272.0
ESYT2	-8271.0
MVD	-8259.0
DDAH1	-8257.0
DCTPP1	-8243.0
GLUL	-8242.0
RFK	-8238.0
GLTP	-8236.0
SLC16A3	-8234.0
POM121	-8211.0
SMOX	-8210.0
PRKACB	-8206.0
PDP2	-8204.0
IPMK	-8193.0
ARSK	-8181.0
MINPP1	-8180.0
PI4K2A	-8161.0
PANK1	-8160.0
DDHD1	-8145.0
TYMS	-8139.0
ELOVL4	-8126.0
PAPSS1	-8119.0
POR	-8116.0
CYB5R3	-8103.0
PSMC1	-8097.0
ITPKB	-8096.0
PIK3C3	-8086.0
SUCLA2	-8074.0
LPCAT2	-8072.0
SDC2	-8067.0
CDIPT	-8055.0
MED20	-8046.0
PSMA2	-8025.0
ST3GAL1	-8021.0
MTMR4	-8019.0
EXT2	-8015.0
GALK1	-8007.0
INSIG2	-7996.0
PSME3	-7994.0
PPA1	-7993.0
NDUFS1	-7990.0
INPP5F	-7989.0
MBOAT7	-7984.0
PIK3C2A	-7978.0
ABCC1	-7976.0
KCNS3	-7970.0
HADHA	-7967.0
INPP5A	-7936.0
LRP1	-7925.0
UBIAD1	-7923.0
ISCA1	-7911.0
FUT10	-7910.0
PDK3	-7909.0
GDE1	-7890.0
SLC35D1	-7884.0
ST3GAL6	-7878.0
OCRL	-7866.0
MTMR9	-7864.0
HSD17B11	-7860.0
NUP133	-7859.0
PDSS2	-7845.0
CHPT1	-7836.0
GLS	-7832.0
RRM2B	-7827.0
NADK2	-7823.0
INPP4A	-7786.0
GYG1	-7784.0
ADPRM	-7775.0
PPIP5K2	-7773.0
PIP4K2C	-7769.0
NDUFS2	-7766.0
RPIA	-7757.0
SEH1L	-7750.0
IARS1	-7742.0
RIMKLA	-7736.0
BCKDK	-7728.0
STARD7	-7717.0
PSMB5	-7716.0
PIP5K1A	-7714.0
HPRT1	-7699.0
FUT11	-7695.0
VDAC1	-7693.0
ETNK2	-7689.0
SHPK	-7671.0
B4GALT4	-7629.0
ACOX1	-7620.0
EXT1	-7609.0
SCP2	-7608.0
ENOPH1	-7603.0
HPSE	-7585.0
CIAPIN1	-7584.0
GLDC	-7581.0
ORMDL3	-7558.0
UST	-7553.0
LTA4H	-7552.0
RPL7	-7545.0
SDHB	-7529.0
SLC44A1	-7527.0
SACM1L	-7515.0
TBL1X	-7506.0
OAT	-7505.0
MLX	-7504.0
PLIN2	-7496.0
GNPDA1	-7481.0
PRKAG2	-7476.0
GSR	-7474.0
NMNAT2	-7471.0
PLA2G12A	-7470.0
NNT	-7468.0
PYGB	-7437.0
GPD2	-7409.0
SGPL1	-7400.0
PDP1	-7399.0
HMMR	-7394.0
OSBPL1A	-7386.0
ELOVL7	-7383.0
GNAQ	-7376.0
FHL2	-7370.0
ME1	-7369.0
LPCAT1	-7363.0
NFS1	-7358.0
ESD	-7354.0
ATP5PB	-7343.0
AHR	-7341.0
PSMD14	-7340.0
SDHC	-7321.0
CMBL	-7319.0
PTEN	-7317.0
LPGAT1	-7314.0
HACL1	-7309.0
HILPDA	-7303.0
AASDHPPT	-7290.0
PPT1	-7281.0
NCOR2	-7277.0
ACAT1	-7268.0
GCH1	-7262.0
QDPR	-7260.0
AMACR	-7255.0
SLC6A8	-7254.0
VKORC1	-7253.0
MTMR3	-7248.0
SUMO2	-7239.0
PI4K2B	-7232.0
CDK19	-7228.0
AGRN	-7222.0
TKT	-7218.0
SDHD	-7213.0
EEF1E1	-7212.0
GPAM	-7211.0
POM121C	-7209.0
PRKAA2	-7203.0
CRLS1	-7198.0
PLEKHA3	-7192.0
GCLC	-7185.0
LPIN1	-7178.0
MAN2B1	-7158.0
AACS	-7138.0
RPL41	-7130.0
TPMT	-7121.0
RAP1A	-7117.0
HEXB	-7110.0
DNM2	-7104.0
RPS5	-7102.0
PCCA	-7101.0
AGPAT1	-7092.0
ACADM	-7088.0
MTRR	-7086.0
NDUFAB1	-7080.0
NSDHL	-7077.0
PSMD10	-7034.0
MED10	-7028.0
MTHFD1L	-7026.0
CHST7	-7023.0
G6PD	-7017.0
HMOX2	-7012.0
AHCY	-7006.0
B4GALT5	-7005.0
NCOA6	-6993.0
PSMA6	-6980.0
BPNT1	-6975.0
MTMR1	-6965.0
UBC	-6964.0
ABHD4	-6960.0
MED26	-6943.0
PCYT1A	-6929.0
PLD6	-6924.0
RAN	-6907.0
PSMC6	-6903.0
AMPD3	-6902.0
CTPS2	-6896.0
AIMP2	-6895.0
SGMS2	-6871.0
PRKAR2B	-6868.0
MID1IP1	-6862.0
GLO1	-6860.0
RPLP0	-6852.0
UCK2	-6827.0
ACER3	-6805.0
NUDT19	-6787.0
UMPS	-6785.0
SDC1	-6782.0
GNB5	-6775.0
UGT8	-6761.0
OSBPL3	-6749.0
PSMD9	-6748.0
NUP214	-6714.0
ACACA	-6705.0
CHD9	-6687.0
IMPA1	-6682.0
PIAS4	-6675.0
PLA2G15	-6658.0
ADCY2	-6656.0
PCTP	-6651.0
B4GALNT2	-6647.0
SUMF2	-6644.0
BTD	-6623.0
NUBPL	-6610.0
TMLHE	-6593.0
MED30	-6553.0
TRIB3	-6551.0
THRAP3	-6535.0
OXCT1	-6513.0
MED19	-6510.0
GNPDA2	-6495.0
SARS1	-6479.0
NR1D1	-6478.0
MMAA	-6462.0
CBR4	-6453.0
NCOA1	-6430.0
CERK	-6429.0
IDH3A	-6427.0
RXRB	-6426.0
NRF1	-6410.0
PLPP1	-6400.0
PPP2R1A	-6397.0
ABHD5	-6395.0
RGL1	-6389.0
ST3GAL2	-6385.0
LDHB	-6384.0
SLC35B3	-6342.0
SMPD1	-6334.0
ADH5	-6331.0
PIP5K1B	-6325.0
SYNJ1	-6310.0
MTM1	-6304.0
KARS1	-6293.0
CBR1	-6291.0
FITM2	-6279.0
VCAN	-6274.0
PGD	-6249.0
DEGS1	-6232.0
HMGCL	-6211.0
B4GALT2	-6208.0
DSEL	-6203.0
CA2	-6187.0
RPE	-6186.0
CSPG5	-6185.0
GNG2	-6160.0
MBTPS1	-6159.0
ACOX3	-6154.0
ST6GALNAC6	-6141.0
GAPDH	-6139.0
NDUFS4	-6131.0
PSMB2	-6126.0
TNFAIP8	-6118.0
ITPR3	-6102.0
RPL3	-6101.0
OSBPL2	-6100.0
RXRA	-6096.0
SDC3	-6073.0
PSMA1	-6072.0
COX5A	-6065.0
MTHFR	-6064.0
IDH1	-6055.0
AGPS	-6040.0
CARM1	-6020.0
HSD17B7	-6016.0
CYC1	-5983.0
KCNJ11	-5973.0
NEU1	-5969.0
PLAAT1	-5967.0
MAOA	-5953.0
MED17	-5938.0
CDS2	-5934.0
RPL23A	-5925.0
DPYD	-5922.0
NUDT10	-5909.0
UPP1	-5907.0
THTPA	-5902.0
AK6	-5887.0
ETNK1	-5871.0
GGCT	-5869.0
CDS1	-5865.0
HACD1	-5855.0
NUDT15	-5846.0
PUDP	-5837.0
GATM	-5835.0
GOT1	-5832.0
SCO2	-5829.0
HDAC3	-5788.0
ALDH1B1	-5779.0
CD320	-5774.0
FDPS	-5771.0
SPTSSA	-5754.0
RPS3A	-5741.0
ABCA1	-5728.0
EEFSEC	-5718.0
HSD17B4	-5717.0
LSS	-5697.0
B3GALT1	-5688.0
CYP27B1	-5681.0
GGPS1	-5677.0
NAGS	-5674.0
TRAP1	-5660.0
MED29	-5650.0
PPT2	-5632.0
PANK4	-5608.0
CA12	-5607.0
ACER2	-5604.0
GMPR2	-5592.0
GNAI2	-5591.0
OAZ1	-5574.0
CHST15	-5572.0
PHKA1	-5571.0
SLC25A44	-5546.0
IDH3B	-5545.0
PSMD12	-5542.0
IMPDH1	-5534.0
GM2A	-5533.0
CTPS1	-5532.0
MTMR10	-5507.0
PRKCA	-5486.0
RPL21	-5480.0
PIK3R2	-5467.0
HSPG2	-5446.0
HTD2	-5442.0
RPS29	-5438.0
DARS1	-5437.0
SLC25A20	-5423.0
FAM120B	-5422.0
UQCRC1	-5416.0
FAR2	-5407.0
ATIC	-5401.0
PTGR1	-5397.0
HADH	-5395.0
MED6	-5377.0
NUP50	-5376.0
SRD5A1	-5372.0
ARNTL	-5371.0
OSBPL5	-5363.0
PEX11A	-5348.0
COX14	-5346.0
ISCA2	-5343.0
UBE2I	-5331.0
AKR1A1	-5323.0
B3GALNT1	-5308.0
PIK3R3	-5298.0
PARP16	-5296.0
CYP2S1	-5271.0
NUP35	-5266.0
ITPKA	-5255.0
DGAT2	-5234.0
NUDT7	-5228.0
COX11	-5188.0
PLCB3	-5168.0
RPL13A	-5167.0
RPS27A	-5160.0
QPRT	-5151.0
HSCB	-5120.0
MVK	-5111.0
SBF1	-5103.0
SLC44A5	-5101.0
TXN2	-5068.0
NUP62	-5048.0
GNG10	-5038.0
GNG5	-5034.0
CHRM3	-5017.0
PPARG	-4993.0
PPP2R1B	-4990.0
CA14	-4982.0
GCSH	-4978.0
CYP24A1	-4950.0
AOX1	-4939.0
B4GALT7	-4927.0
CYP2U1	-4917.0
PLCH2	-4912.0
HSD17B8	-4905.0
PLA2G5	-4904.0
NUP37	-4886.0
PLD1	-4856.0
GLRX5	-4855.0
PLCD1	-4840.0
HAS3	-4832.0
MED27	-4830.0
FH	-4807.0
GUK1	-4804.0
MCEE	-4803.0
SCAP	-4798.0
TSPO	-4796.0
PLCH1	-4790.0
GRHL1	-4778.0
ANGPTL4	-4769.0
CERS4	-4767.0
GALC	-4756.0
PISD	-4736.0
CPT1A	-4734.0
APOA5	-4726.0
MPC2	-4708.0
CA5B	-4699.0
SLC25A17	-4698.0
ST3GAL3	-4695.0
TPR	-4678.0
ENPP1	-4677.0
PGS1	-4652.0
RHCE	-4649.0
PPP1CA	-4633.0
TALDO1	-4624.0
MGLL	-4618.0
PDPR	-4544.0
QARS1	-4520.0
AIMP1	-4481.0
GPD1L	-4474.0
NDUFC2	-4456.0
MMS19	-4443.0
COX16	-4441.0
XYLT2	-4430.0
TACO1	-4423.0
LIAS	-4421.0
PSMA4	-4415.0
OSBPL6	-4390.0
CYCS	-4372.0
MCAT	-4357.0
HS6ST2	-4345.0
MED16	-4342.0
NMNAT1	-4336.0
DERA	-4294.0
CHPF	-4285.0
XDH	-4261.0
MCCC1	-4252.0
KYAT1	-4227.0
PNPLA2	-4213.0
GPC5	-4208.0
ASRGL1	-4197.0
SLC44A2	-4191.0
DTYMK	-4185.0
ADRA2A	-4176.0
INPP5D	-4161.0
MED9	-4151.0
MED4	-4146.0
ST3GAL4	-4135.0
FIG4	-4129.0
GNG11	-4107.0
SLC25A11	-4100.0
MDH1	-4077.0
SPR	-4055.0
ASAH2	-4038.0
GOT2	-4032.0
RAB4A	-4025.0
ACOX2	-4019.0
FDXR	-4001.0
MED23	-3994.0
SLC25A1	-3979.0
AMPD2	-3966.0
SLC35D2	-3959.0
GSTM3	-3958.0
RPL10	-3951.0
OAZ2	-3924.0
ARSB	-3904.0
ATP5F1E	-3884.0
IPPK	-3878.0
COX18	-3870.0
RAPGEF3	-3838.0
ADSL	-3836.0
PSMB6	-3827.0
B3GNT3	-3826.0
PIK3CD	-3823.0
MED15	-3809.0
PRKG2	-3801.0
PTGS1	-3797.0
ARSI	-3787.0
SLC9A1	-3774.0
SAR1B	-3725.0
ADCY6	-3718.0
GCAT	-3705.0
ATP5MC3	-3689.0
HS6ST3	-3686.0
FXN	-3670.0
GNPAT	-3663.0
CKB	-3661.0
FDX1	-3655.0
MOCOS	-3652.0
BLVRB	-3636.0
DHFR2	-3635.0
PRKD1	-3616.0
SUCLG1	-3607.0
TCN2	-3559.0
PIK3CG	-3556.0
HLCS	-3543.0
SLC37A1	-3542.0
SUMF1	-3539.0
HSD3B2	-3515.0
ALDH1L1	-3484.0
PLD2	-3462.0
LYRM4	-3416.0
TIAM2	-3393.0
STARD10	-3378.0
FECH	-3323.0
SEPSECS	-3295.0
PHYH	-3294.0
CRYM	-3272.0
GLRX	-3264.0
NDUFA4	-3230.0
ELOVL2	-3214.0
SLC23A2	-3186.0
UBB	-3180.0
SLC37A4	-3155.0
HSD3B1	-3129.0
PLCE1	-3127.0
GDA	-3071.0
RPS12	-3070.0
GDPD1	-2995.0
PTGIS	-2990.0
B4GAT1	-2972.0
PARP14	-2951.0
ABCG2	-2942.0
PARP8	-2928.0
PLCG2	-2906.0
GPAT4	-2898.0
HMOX1	-2896.0
SLC6A11	-2879.0
NT5C1B	-2877.0
B3GALT4	-2842.0
CHAC2	-2778.0
NUP43	-2776.0
CYP26C1	-2755.0
LPCAT3	-2721.0
GDPD5	-2717.0
GPC2	-2676.0
ENPP2	-2630.0
CYP11A1	-2616.0
RIMKLB	-2583.0
AKT1	-2579.0
PIK3R5	-2536.0
RPS27	-2527.0
KHK	-2513.0
DCN	-2486.0
PSMC2	-2444.0
NDUFAF4	-2437.0
ASS1	-2390.0
PPA2	-2389.0
HSD17B2	-2341.0
LPCAT4	-2330.0
CYP1A1	-2325.0
CHAT	-2306.0
NDUFAF1	-2299.0
SLC46A1	-2247.0
FABP3	-2202.0
CYSLTR2	-2195.0
PFKM	-2189.0
PNPO	-2157.0
TPK1	-2148.0
HSD11B1	-2138.0
MED18	-2137.0
OAZ3	-2104.0
BLVRA	-2057.0
MED12	-1920.0
NFYB	-1906.0
NUDT18	-1856.0
IDH3G	-1805.0
AK7	-1774.0
PPP1R3C	-1767.0
CKMT2	-1755.0
SLC25A19	-1691.0
STARD3	-1637.0
TIMMDC1	-1624.0
VDR	-1604.0
RPS9	-1595.0
NDUFB6	-1580.0
TMEM186	-1524.0
FUT5	-1512.0
HSD3B7	-1511.0
XYLB	-1504.0
HIBCH	-1474.0
CTRB2	-1467.0
PEMT	-1461.0
RPL22	-1380.0
SLC51B	-1355.0
AGL	-1338.0
UGT3A2	-1326.0
CYB5B	-1315.0
RPS2	-1189.0
CDA	-1144.0
COQ5	-1140.0
HPSE2	-1054.0
DCT	-1043.0
GLS2	-1013.0
NAXE	-997.0
ABCB1	-978.0
PIK3C2B	-976.0
UGT1A1	-971.0
CTRB1	-970.0
SLC25A21	-941.0
AMN	-927.0
IL4I1	-920.0
ALOX5	-905.0
GLUD2	-879.0
PRXL2B	-878.0
GNA14	-873.0
RPL30	-868.0
ARSD	-775.0
PLA2G4F	-762.0
MLYCD	-701.0
PFKFB2	-695.0
AUH	-639.0
TMEM126B	-638.0
ALOX12	-625.0
GCK	-608.0
IP6K2	-591.0
COX8A	-557.0
CIAO1	-510.0
GSTM5	-492.0
SHMT2	-491.0
AK5	-464.0
SERINC4	-438.0
CHST9	-423.0
HPGD	-413.0
FOLH1	-381.0
SLCO1A2	-372.0
GBA	-369.0
KCNG2	-365.0
MOCS1	-362.0
ECSIT	-357.0
FUT1	-343.0
LARS1	-324.0
SLC27A2	-319.0
HPD	-316.0
AKAP5	-305.0
NT5C1A	-294.0
HS3ST6	-255.0
CA7	-249.0
MTMR14	-241.0
SLC22A13	-216.0
BST1	-175.0
AASS	-162.0
ADI1	-133.0
CYP26A1	-54.0
FBP2	-15.0
SPTLC3	19.0
LRP2	38.0
PMVK	64.0
PLCB1	69.0
HS3ST5	79.0
NOS3	107.0
NAT1	127.0
B3GAT2	141.0
OCA2	183.0
SLCO2B1	197.0
UQCR11	224.0
ETFDH	239.0
CACNB3	260.0
GLIPR1	277.0
PLA2G10	291.0
PARP4	305.0
RPL22L1	317.0
PDSS1	347.0
PPARGC1A	368.0
SLC3A2	386.0
EPM2A	395.0
BCKDHB	410.0
PLD3	414.0
SLC27A1	427.0
AGXT	438.0
SLC5A5	465.0
PRSS1	475.0
AKR1C1	483.0
COASY	498.0
ME3	504.0
COQ2	514.0
MBOAT1	648.0
SLC22A3	650.0
INPP5K	658.0
MTHFD1	667.0
CNDP2	695.0
ACOT4	734.0
SPTSSB	778.0
ACADS	781.0
FAR1	786.0
CKM	866.0
DMAC2L	871.0
GPX2	952.0
ARG1	959.0
AKR1B15	968.0
PLPP6	1068.0
FABP4	1084.0
RPL18A	1090.0
ARSL	1105.0
DBH	1120.0
TTPA	1130.0
HOGA1	1132.0
TDH	1137.0
CYP4A11	1168.0
ERCC2	1171.0
PITPNM3	1185.0
B3GNT7	1209.0
PRKACA	1217.0
RPSA	1280.0
FABP2	1286.0
ADCY4	1293.0
STS	1333.0
NUBP2	1335.0
CYP1A2	1343.0
PDK4	1456.0
SYT5	1485.0
CYP8B1	1487.0
ALOXE3	1506.0
FLVCR1	1536.0
GNG3	1558.0
CYP4F12	1584.0
DGAT1	1629.0
SULT2B1	1650.0
CERS3	1671.0
CD38	1707.0
SAMHD1	1710.0
CYB5A	1727.0
B3GNT4	1737.0
DUOX1	1747.0
ACSL6	1748.0
BCAN	1775.0
HEXA	1777.0
ENTPD1	1802.0
GNA15	1828.0
GLYATL1	1888.0
TNFAIP8L3	1912.0
PNMT	1914.0
ALDH3A2	1920.0
PC	1932.0
ELOVL6	1965.0
LIPT2	1989.0
RNLS	2070.0
NAGLU	2095.0
CERS5	2117.0
PSMD13	2181.0
SLC22A1	2188.0
LIPT1	2208.0
NUDT12	2211.0
PIK3R6	2238.0
SLC51A	2243.0
OLAH	2258.0
CHST1	2285.0
CYP4F3	2300.0
PTGDS	2334.0
CSNK1G2	2344.0
HAL	2361.0
SPNS2	2372.0
CDO1	2375.0
MTMR7	2433.0
PPCS	2565.0
AANAT	2583.0
TCN1	2744.0
SLC23A1	2784.0
ACSM3	2790.0
ACSBG2	2809.0
AOC1	2851.0
ECHS1	2857.0
CIDEC	2888.0
BCHE	2903.0
NHLRC1	2910.0
GPX1	2991.0
DBI	3041.0
ENPP6	3048.0
RPS17	3103.0
THEM5	3121.0
NCAN	3166.0
GYG2	3176.0
AK2	3213.0
SRD5A2	3229.0
HSD11B2	3249.0
CYP2B6	3283.0
BCAT2	3331.0
CYP2W1	3340.0
PDHB	3379.0
MRI1	3424.0
HS3ST2	3481.0
CTSA	3490.0
TTR	3596.0
ESRRA	3600.0
RPS10	3602.0
LDHAL6B	3617.0
GRHPR	3632.0
ADCY5	3633.0
AKR1D1	3687.0
NR1H4	3743.5
PLA2G4E	3748.0
GLP1R	3759.0
LDHC	3789.0
RPS3	3800.0
DDO	3809.0
GADL1	3839.0
HS3ST4	3850.0
GLYATL2	3863.0
NME2	3888.0
COQ7	3905.0
BRIP1	4013.0
CACNA1E	4024.0
LRAT	4056.0
NQO2	4068.0
CYP39A1	4122.0
SLC52A1	4193.0
AFMID	4226.0
SLC44A3	4289.0
SRR	4292.0
NR1H2	4351.0
APIP	4353.0
SLC19A3	4362.0
HNMT	4366.0
SEPHS2	4386.0
CYP2J2	4465.0
PSME1	4473.0
LDHAL6A	4524.0
RPL27	4534.0
PLA1A	4537.0
MED22	4548.0
PSMB8	4550.0
MMAB	4558.0
INPP4B	4559.0
DIO1	4587.0
ALDH4A1	4619.0
STAR	4641.0
SULT2A1	4658.0
GSTT2	4661.0
CYP19A1	4680.0
ADH6	4707.0
RPS23	4723.0
ADIPOQ	4755.0
SPHK2	4790.0
AK8	4794.0
ACBD6	4814.0
CTH	4819.0
AGMAT	4862.0
ACSF3	4933.0
CD36	4945.0
ACSL5	4976.0
PXMP2	5099.0
PTGR2	5121.0
EPHX2	5122.0
TPH2	5162.0
G0S2	5172.0
PAOX	5185.0
AK9	5205.0
TAT	5211.0
TDO2	5214.0
ENPP3	5233.0
BHMT	5271.0
FPGS	5272.0
UGT3A1	5283.0
MED24	5286.0
TPTE2	5327.0
ACOT6	5334.0
FAHD1	5378.0
ABO	5428.0
GSTM1	5435.0
AS3MT	5436.0
HIBADH	5460.0
SULT1B1	5482.0
MED28	5498.0
GNG13	5499.0
ALOX15	5554.0
CERS1	5561.0
RPL7A	5578.0
ADAL	5587.0
PLIN1	5652.0
GCKR	5694.0
PIP5K1C	5703.0
INPP5B	5756.0
MCCC2	5772.0
SMPD2	5780.0
PLA2G4D	5882.0
MOGAT3	5940.0
TPO	5943.0
COX20	5997.0
GGT6	6019.0
ASPA	6085.0
INPP1	6096.0
GNGT2	6118.0
NDST3	6138.0
PSMA3	6151.0
IDO1	6233.0
GLYCTK	6250.0
SECISBP2	6252.0
BAAT	6255.0
NDUFA9	6256.0
NOSTRIN	6274.0
PRELP	6340.0
PCK1	6374.0
UPB1	6380.0
ALDOB	6382.0
FUT6	6518.0
RPL8	6573.0
CPS1	6592.0
PLBD1	6594.0
CYP7B1	6670.0
SLC6A12	6696.0
ASAH1	6709.0
APRT	6727.0
ENO2	6735.0
COQ9	6791.0
CYP4F11	6804.0
ACY3	6826.0
ENTPD5	6856.0
INMT	6860.0
ATP5PF	6886.0
SDS	6898.0
APOC2	6916.0
RPL39	6918.0
UQCRH	6925.0
SGPP2	6965.0
RBP4	7004.0
PI4KA	7020.0
UCP2	7024.0
SERINC2	7070.0
FMO3	7099.0
RPL15	7111.0
PLCD3	7142.0
AADAC	7162.0
LIPE	7202.0
SLC7A5	7232.0
RBKS	7246.0
ACO2	7258.0
HACD4	7283.0
SULT1A2	7297.0
CYP4F8	7369.0
CTRC	7373.0
CYP3A43	7374.0
AGPAT2	7378.0
NDUFB11	7425.0
PNPLA4	7432.0
OMD	7439.0
OXCT2	7459.0
GAA	7496.0
LHB	7555.0
MGST1	7563.0
HSD17B3	7598.0
NCOR1	7630.0
UCK1	7636.0
HGD	7654.0
RPS13	7670.0
ZDHHC21	7676.0
CA6	7689.0
PDK2	7726.0
SULT1C4	7826.0
SLC44A4	7833.0
IDO2	7836.0
CHST13	7846.0
ABCB4	7858.0
B4GALNT1	7875.0
CSNK2B	7911.0
SYNJ2	7924.0
PSMB1	7962.0
ALOX12B	7985.0
PSTK	7998.0
GUSB	8010.0
GSTM4	8017.0
MOCS3	8028.0
COQ3	8056.0
CBR3	8089.0
PNPLA6	8139.0
ANKRD1	8148.0
ACBD7	8176.0
ACOT1	8213.0
GPAT2	8303.0
CBSL	8352.0
B3GAT1	8389.0
PGAM2	8435.0
MMACHC	8463.0
EBP	8521.0
HSD17B13	8523.0
CA3	8527.0
SULT1A4	8531.0
PANK2	8542.0
HMBS	8551.0
HYKK	8577.0
PCBD1	8578.0
SLC22A5	8661.0
NUDT5	8759.0
SLC27A3	8777.0
ACHE	8779.0
TSPOAP1	8805.0
AIP	8843.0
NDUFAF7	8918.0
SARDH	8920.0
VNN1	8967.0
GNMT	8976.0
SERPINA6	9012.0
PCYT1B	9025.0
ACP5	9106.0
CYP27A1	9125.0
PFKFB1	9158.0
SLC25A10	9178.0
PSMB9	9240.0
ADPGK	9243.0
NUDT16	9251.0
KCNB1	9252.0
PLCD4	9260.0
AZIN2	9279.0
CA13	9283.0
ALDH1L2	9297.0
PECR	9315.0
AGT	9340.0
DMGDH	9342.0
ACADSB	9405.0
MPC1	9409.0
PRKAR1B	9412.0
NDUFAF5	9415.0
CHST14	9418.0
GGT5	9428.0
IYD	9491.0
SDSL	9499.0
ACSBG1	9515.0
MTARC2	9531.0
AKR1C2	9537.0
ADH1B	9548.0
LIPH	9606.0
HSD17B1	9607.0
ADRA2C	9608.0
PIPOX	9613.0
APOM	9637.0
NDUFA10	9639.0
SRM	9656.0
CACNA1C	9657.0
PLD4	9661.0
ETFB	9673.0
PSMC5	9697.0
COX7C	9745.0
MECR	9754.0
UROC1	9756.0
NDUFB9	9766.0
RPS6	9808.0
ACADL	9829.0
IVD	9830.0
HYAL1	9882.0
PTPN13	9890.0
MAT1A	9896.0
RHD	9994.0
DHRS7B	10001.0
ORMDL2	10016.0
RPL3L	10061.0
GSTZ1	10128.0
ABCC8	10134.0
B3GAT3	10162.0
PTPMT1	10176.0
CYP3A5	10193.0
FITM1	10201.0
FLAD1	10236.0
GSTA4	10243.0
PLEKHA6	10266.0
MAT2A	10268.0
LPIN3	10276.0
MTHFD2L	10298.0
NUP85	10330.0
CYP46A1	10347.0
BGN	10349.0
TK1	10358.0
PPARD	10370.0
GSTO1	10398.0
LTC4S	10410.0
CHST5	10433.0
B3GALT5	10468.0
COQ10A	10498.0
PSMD4	10510.0
PYGM	10547.0
RPL26	10563.0
PODXL2	10566.0
MTARC1	10583.0
LHPP	10592.0
ABHD14B	10602.0
MTAP	10618.0
PLPP2	10620.0
PSMC3	10621.0
DUOX2	10675.0
FDX2	10721.0
RPL26L1	10754.0
CARNS1	10775.0
PSPH	10781.0
RPL5	10785.0
KMO	10817.0
SLC5A6	10832.0
SCLY	10833.0
SURF1	10834.0
MIOX	10867.0
PSMC4	10904.0
NOSIP	10918.0
ACOT9	10960.0
VAMP2	10963.0
NEU4	11018.0
GPD1	11020.0
GNG7	11025.0
TST	11063.0
CES3	11069.0
RPL36AL	11075.0
PLCB2	11077.0
NDUFA5	11096.0
ACSM2A	11109.0
RPS25	11123.0
APOA1	11144.0
MGST3	11153.0
RPS11	11194.0
PHOSPHO1	11209.0
NUDT1	11224.0
UCP3	11239.0
ACSS1	11266.0
PRODH	11281.0
ATP5MC2	11283.0
ARSG	11295.0
PTDSS2	11303.0
RPS8	11338.0
ALDH7A1	11350.0
NUP42	11356.0
CYP2R1	11360.0
NAALAD2	11362.0
SLC19A1	11371.0
STK11	11373.0
UGT1A7	11410.0
ACY1	11413.0
PDHA1	11421.0
CROT	11427.0
NDUFV1	11451.0
MED31	11461.0
ISCU	11464.0
ACAD10	11469.0
MED25	11488.0
UBA52	11501.0
ABHD3	11513.0
SULT1A1	11521.0
COA1	11532.0
GLA	11555.0
ORMDL1	11582.0
NUDT13	11585.0
MED7	11602.0
ALDH3B1	11612.0
UROD	11624.0
BDH1	11627.0
STARD5	11654.0
GSTO2	11664.0
RIDA	11695.0
PPCDC	11718.0
KYNU	11755.0
PTS	11759.0
CKMT1A	11765.0
TKFC	11770.0
SLC26A1	11771.0
HYAL2	11775.0
ACACB	11796.0
ACSF2	11821.0
CIAO2B	11836.0
CACNA2D2	11848.0
NDUFB3	11906.0
FAAH	11907.0
FAH	11909.0
COX19	11950.0
ATP5F1C	11955.0
PSMB7	11959.0
GLB1L	11965.0
GGT7	12032.0
NUP210	12037.0
RPS19	12039.0
NDUFC1	12063.0
SLC25A14	12104.0
RPL35A	12114.0
NDUFB2	12149.0
ENTPD6	12190.0
FABP6	12205.0
ITPK1	12219.0
CPTP	12223.0
CYP21A2	12227.0
AOC2	12246.0
CHST12	12263.0
NDUFAF6	12264.0
ALB	12279.0
PSMD6	12288.0
FUT2	12289.0
SULT1C2	12291.0
FUT3	12302.0
PCYT2	12310.0
GCHFR	12326.0
CYP4V2	12361.0
SLC27A5	12369.0
NT5M	12371.0
TBXAS1	12372.0
MORC2	12384.0
ESYT3	12397.0
AKR7A3	12420.0
NMNAT3	12426.0
NDUFS6	12427.0
RPS14	12432.0
ATP5PO	12433.0
ABCC2	12434.0
BHMT2	12466.0
ACOXL	12472.0
GGT1	12473.0
NDUFB7	12482.0
RPS4X	12510.0
GNG4	12514.0
AOC3	12520.0
GSTP1	12527.0
GCDH	12537.0
ATP5MC1	12566.0
ACSM2B	12578.0
POLD1	12587.0
PLEKHA4	12588.0
NDUFAF2	12597.0
AGK	12603.0
DHODH	12613.0
DDAH2	12623.0
HAAO	12631.0
NFYC	12639.0
ACP6	12649.0
NDUFV3	12653.0
HSD17B10	12668.0
PLB1	12674.0
ITPA	12681.0
MAN2B2	12687.0
DNPH1	12690.0
HYAL3	12709.0
ACBD4	12744.0
RPL37A	12745.0
PLA2R1	12758.0
GMPR	12781.0
RAPGEF4	12792.0
TPH1	12796.0
RPL6	12805.0
MAOB	12815.0
GPX4	12824.0
NDUFB10	12853.0
NUDT9	12860.0
AMDHD1	12862.0
CYP26B1	12884.0
DCXR	12907.0
PPOX	12914.0
PARP9	12931.0
CHPF2	12956.0
AKR1B1	12976.0
NAPRT	12995.0
INPP5J	13004.0
N6AMT1	13005.0
SLC25A12	13018.0
UQCR10	13028.0
NADSYN1	13031.0
PLAAT4	13035.0
PFKFB4	13053.0
GALT	13076.0
PLA2G4C	13078.0
NT5C2	13080.0
PTGES2	13091.0
ACOT2	13094.0
SNAP25	13126.0
BCO2	13128.0
MPST	13133.0
GSS	13160.0
ADHFE1	13162.0
PIP4K2B	13190.0
ATP5MG	13198.0
NDUFS3	13204.0
GPT	13220.0
ENTPD8	13240.0
PTGES	13250.0
SHMT1	13252.0
NR1H3	13263.0
INPP5E	13264.0
PON2	13266.0
BPHL	13296.0
PGP	13302.0
RPL11	13315.0
SLC25A13	13332.0
RPS15A	13339.0
B3GALT6	13353.0
PITPNM2	13360.0
CHDH	13363.0
CH25H	13375.0
RPS28	13379.0
RPS7	13381.0
NADK	13400.0
ACADVL	13413.0
BSG	13431.0
COMT	13437.0
PYCR2	13441.0
ABCD1	13461.0
SMPD3	13463.0
DGUOK	13488.0
PHKG1	13494.0
NMRAL1	13500.0
PARP10	13506.0
CYP2D6	13510.0
GPT2	13513.0
DEGS2	13551.0
NDUFA11	13563.0
AKR7L	13568.0
PARP6	13570.0
NDUFS7	13575.0
RPLP1	13585.0
GNB3	13587.0
MED11	13598.0
DIO2	13613.0
RPS16	13615.0
CPNE1	13631.0
OSBPL7	13639.0
G6PC3	13642.0
CYP2E1	13658.0
ENTPD4	13670.0
DUT	13680.0
ARV1	13685.0
ALDH2	13687.0
AK1	13688.0
SGSH	13690.0
SULT1A3	13701.0
RPL36	13703.0
ACAA1	13724.0
CACNB2	13741.0
ARSA	13752.0
RPL13	13761.0
RPL4	13766.0
GDPD3	13779.0
NDUFA6	13790.0
PCK2	13799.0
TYMP	13847.0
SMPD4	13872.0
ASL	13877.0
RPS20	13888.0
PSMB4	13901.0
RPS21	13924.0
RPS18	13929.0
PSMB10	13932.0
NUBP1	13943.0
NDUFA12	13944.0
RPS24	13945.0
NAXD	13961.0
PNPLA7	13968.0
MT-ND6	13969.0
COQ6	13970.0
NME4	13991.0
RPL9	14000.0
SLC37A2	14008.0
NQO1	14023.0
D2HGDH	14030.0
PSAT1	14035.0
RPLP2	14036.0
OPLAH	14044.0
MT-ND4	14079.0
DECR1	14087.0
ACOT8	14088.0
MIGA2	14096.0
GAMT	14112.0
RPS27L	14115.0
MTHFS	14123.0
RBP1	14133.0
MT-ND5	14139.0
TMEM86B	14145.0
SLC25A16	14154.0
GSTK1	14157.0
AADAT	14188.0
RPL17	14216.0
MANBA	14222.0
ACSS2	14227.0
MT-ATP6	14231.0
RPL32	14237.0
NPAS2	14242.0
PDZD11	14254.0
ACSS3	14262.0
MT-ND1	14264.0
UROS	14269.0
NDUFB4	14290.0
CYGB	14301.0
HAGH	14302.0
DECR2	14308.0
HSD17B14	14312.0
AGPAT4	14316.0
RPL19	14317.0
NDUFA8	14321.0
ENO3	14333.0
RPL29	14344.0
CACNA1D	14372.0
MOCS2	14384.0
ACAD9	14402.0
RPL24	14403.0
NT5C	14409.0
ALAD	14428.0
RUFY1	14434.0
RPL12	14435.0
RPL27A	14452.0
COX6C	14453.0
ACOT11	14462.0
CIAO3	14466.0
GSTT2B	14475.0
NDUFA2	14481.0
NDUFA13	14484.0
NDUFS8	14487.0
MT-ND2	14490.0
FTCD	14496.0
PSMB3	14498.0
NMRK1	14501.0
RPL23	14502.0
INPPL1	14521.0
AAAS	14527.0
SAT1	14537.0
MT-CO2	14552.0
TRMT112	14562.0
STX1A	14568.0
CES1	14580.0
PPIP5K1	14581.0
GNAS	14595.0
PGLS	14607.0
MT-ATP8	14608.0
SIN3B	14623.0
PHKA2	14642.0
RPL31	14644.0
AMT	14650.0
RTEL1	14652.0
UQCRQ	14657.0
SLC25A28	14660.0
PFAS	14665.0
RPL34	14680.0
RPL28	14692.0
FAU	14693.0
TM7SF2	14698.0
RPL18	14701.0
ABCC5	14704.0
RPS15	14717.0
DHFR	14724.0
EPHX1	14729.0
PHKG2	14745.0
RPL35	14750.0
COX4I1	14755.0
SUOX	14764.0
NUP107	14769.0
GPCPD1	14781.0
MT-CO1	14828.0
PLCB4	14856.0
SEM1	14859.0
PHKB	14863.0
NDOR1	14865.0
CBS	14868.0
BDH2	14870.0
AKR1C3	14881.0
PSME2	14893.0
SMARCD3	14895.0
COX7B	14899.0
TECR	14901.0
SREBF1	14902.0
ECI1	14905.0
MARS1	14908.0
RPL14	14922.0
AHRR	14926.0
CSGALNACT1	14929.0
RPL36A	14937.0
UCKL1	14938.0
CHKA	14946.0
COX6B1	14948.0
SULT4A1	14957.0
NDUFB8	14960.0
ATP5PD	14961.0
ATP5MF	14964.0
ATP5F1D	14966.0
MLXIPL	14973.0
GPS2	14974.0
ABCD4	14982.0
RPS26	14986.0
GSTM2	14993.0
GALE	14999.0
MAN2C1	15001.0
MGST2	15006.0
PLAAT3	15007.0
COX6A1	15014.0
APOE	15060.0
ABCC3	15068.0
NDUFA7	15075.0
MT-CO3	15080.0
MT-CYB	15081.0
NME1	15092.0
UQCRB	15101.0
ISYNA1	15103.0
NDUFAF3	15110.0
PHYKPL	15114.0
GBA2	15123.0
ACOT13	15131.0
NDUFS5	15132.0
TXN	15133.0
CUBN	15135.0
CPNE7	15142.0
NNMT	15143.0
ACAD8	15146.0
THEM4	15154.0
RPL37	15167.0
MT-ND3	15179.0
IDUA	15183.0
PHGDH	15187.0
RPL38	15198.0
COX5B	15219.0
NDUFV2	15224.0
FABP5	15240.0
NDUFA1	15253.0
CHAC1	15256.0
SLC25A27	15283.0
CACNA1A	15294.0
CSAD	15319.0
TAZ	15321.0
ACAD11	15328.0
NME3	15334.0
NDUFB1	15346.0
PLCG1	15349.0
PLA2G6	15354.0
ATP5ME	15355.0
CPT1B	15357.0
NDUFA3	15362.0
TK2	15396.0
PLA2G4B	15399.0
ASNS	15423.0
SLC25A37	15425.0
CHKB	15429.0

---

Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis

	8
set	Mitochondrial iron-sulfur cluster biogenesis
setSize	13
pANOVA	0.468
s.dist	-0.116
p.adjustANOVA	0.51

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ISCA1	-7911
NFS1	-7358
ISCA2	-5343
HSCB	-5120
GLRX5	-4855
FDXR	-4001
FXN	-3670
FDX1	-3655
LYRM4	-3416
FDX2	10721
ISCU	11464
SLC25A28	14660
SLC25A37	15425

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ISCA1	-7911
NFS1	-7358
ISCA2	-5343
HSCB	-5120
GLRX5	-4855
FDXR	-4001
FXN	-3670
FDX1	-3655
LYRM4	-3416
FDX2	10721
ISCU	11464
SLC25A28	14660
SLC25A37	15425

---

Mitochondrial translation

Mitochondrial translation

	10
set	Mitochondrial translation
setSize	96
pANOVA	0.0966
s.dist	0.0981
p.adjustANOVA	0.116

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS21	15394
MRPL23	15386
GADD45GIP1	15278
MRPL41	15200
MRPS15	15017
MRPL24	14940
MRPL22	14663
MRPL40	14649
MRPL16	14622
MT-RNR2	14570
MRPL32	14557
MRPS25	14514
MRPL34	14482
MRPL57	14215
MRPS31	14205
MRPL55	14025
MRPL53	14021
MT-RNR1	13895
MRPL47	13830
MRPL27	13707

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS21	15394
MRPL23	15386
GADD45GIP1	15278
MRPL41	15200
MRPS15	15017
MRPL24	14940
MRPL22	14663
MRPL40	14649
MRPL16	14622
MT-RNR2	14570
MRPL32	14557
MRPS25	14514
MRPL34	14482
MRPL57	14215
MRPS31	14205
MRPL55	14025
MRPL53	14021
MT-RNR1	13895
MRPL47	13830
MRPL27	13707
MRPL20	13700
MRPL52	13641
MRRF	13467
MRPL38	12790
MRPL1	12746
MRPL21	12741
MRPS17	12583
MRPS36	12577
MRPL18	12555
PTCD3	12500
AURKAIP1	12485
MRPS26	12484
MRPL48	12040
CHCHD1	11628
MRPS18C	11452
MRPL54	11329
MRPL12	11010
OXA1L	10771
MTIF3	10477
MRPS33	10231
MRPL28	9319
MRPL2	8999
MRPS9	8196
TSFM	5217
MRPL43	4662
MRPL35	4032
MRPS28	3865
MRPL58	2618
MTIF2	2289
MRPL11	1246
MRPS7	686
MRPL36	390
MRPL14	-66
TUFM	-529
MRPS14	-1204
MRPL17	-2738
MRPL51	-2757
MRPS5	-3741
ERAL1	-3916
MRPL39	-4069
MRPL42	-4584
MRPS34	-4626
MRPL19	-4627
MRPL33	-4732
MRPL50	-4755
MRPS18A	-4972
MRPL9	-5153
MRPL46	-5251
MRPS16	-5675
MRPL15	-5690
MRPS12	-5749
MRPL4	-5848
MRPL30	-5849
MRPS11	-5867
MRPS24	-5889
MTFMT	-6052
MRPS22	-6176
DAP3	-6349
MRPS27	-6365
MRPL44	-6631
MTRF1L	-6771
MRPL45	-6788
MRPL10	-7043
MRPS18B	-7312
MRPS10	-7381
MRPL3	-7389
MRPL13	-7422
MRPS23	-7451
GFM2	-8000
MRPL49	-8416
MRPS30	-8663
MRPS35	-8849
MRPS2	-8865
MRPS6	-9774
MRPL37	-9941
GFM1	-9987

---

Mucopolysaccharidoses

Mucopolysaccharidoses

	12
set	Mucopolysaccharidoses
setSize	11
pANOVA	0.601
s.dist	0.0912
p.adjustANOVA	0.601

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IDUA	15183
HGSNAT	13719
SGSH	13690
HYAL1	9882
GUSB	8010
GALNS	6671
NAGLU	2095
ARSB	-3904
IDS	-8425
GLB1	-9697
GNS	-10843

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IDUA	15183
HGSNAT	13719
SGSH	13690
HYAL1	9882
GUSB	8010
GALNS	6671
NAGLU	2095
ARSB	-3904
IDS	-8425
GLB1	-9697
GNS	-10843

---

Mitochondrial protein import

Mitochondrial protein import

	9
set	Mitochondrial protein import
setSize	64
pANOVA	0.276
s.dist	-0.0787
p.adjustANOVA	0.316

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TOMM20	-10705
TOMM70	-10645
CS	-10604
ATP5F1B	-9753
TIMM17A	-9395
SAMM50	-9305
ATP5F1A	-8575
CHCHD3	-8528
PMPCB	-8355
HSPD1	-8345
CHCHD2	-8334
SLC25A6	-8183
VDAC1	-7693
TOMM7	-7580
GRPEL1	-7271
GRPEL2	-7208
HSPA9	-6368
CYC1	-5983
SLC25A4	-5805
TIMM8A	-5521

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TOMM20	-10705
TOMM70	-10645
CS	-10604
ATP5F1B	-9753
TIMM17A	-9395
SAMM50	-9305
ATP5F1A	-8575
CHCHD3	-8528
PMPCB	-8355
HSPD1	-8345
CHCHD2	-8334
SLC25A6	-8183
VDAC1	-7693
TOMM7	-7580
GRPEL1	-7271
GRPEL2	-7208
HSPA9	-6368
CYC1	-5983
SLC25A4	-5805
TIMM8A	-5521
TOMM22	-5449
CHCHD4	-5267
HSCB	-5120
TOMM6	-5003
CMC2	-4783
GFER	-4670
PITRM1	-4248
TIMM21	-4236
COA4	-3875
TIMM22	-3688
FXN	-3670
CMC4	-2304
TIMM9	-1924
IDH3G	-1805
LDHD	-1071
CHCHD5	-1046
TIMM10B	173
CHCHD7	330
TOMM5	353
COQ2	514
COA6	2343
ACO2	7258
MTX2	8174
TIMM10	9317
TIMM17B	9394
TIMM23	9871
TIMM50	10097
COX19	11950
TIMM44	12284
BCS1L	12395
PMPCA	12429
ATP5MC1	12566
TIMM13	12576
SLC25A12	13018
SLC25A13	13332
MTX1	13478
TIMM8B	13627
TOMM40	13798
DNAJC19	14163
PAM16	14765
NDUFB8	14960
CHCHD10	15166
COX17	15217
TAZ	15321

---

Diseases of carbohydrate metabolism

Diseases of carbohydrate metabolism

	3
set	Diseases of carbohydrate metabolism
setSize	31
pANOVA	0.517
s.dist	-0.0673
p.adjustANOVA	0.539

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNS	-10843
GBE1	-10009
GLB1	-9697
IDS	-8425
GYS1	-8322
GYG1	-7784
RPIA	-7757
UBC	-6964
RPS27A	-5160
TALDO1	-4624
ARSB	-3904
UBB	-3180
SLC37A4	-3155
KHK	-2513
PPP1R3C	-1767
EPM2A	395
NAGLU	2095
NHLRC1	2910
GYG2	3176
LCT	3354

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNS	-10843
GBE1	-10009
GLB1	-9697
IDS	-8425
GYS1	-8322
GYG1	-7784
RPIA	-7757
UBC	-6964
RPS27A	-5160
TALDO1	-4624
ARSB	-3904
UBB	-3180
SLC37A4	-3155
KHK	-2513
PPP1R3C	-1767
EPM2A	395
NAGLU	2095
NHLRC1	2910
GYG2	3176
LCT	3354
ALDOB	6382
GALNS	6671
GAA	7496
GUSB	8010
HYAL1	9882
UBA52	11501
DCXR	12907
G6PC3	13642
SGSH	13690
HGSNAT	13719
IDUA	15183

---

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

	6
set	Metabolism of amino acids and derivatives
setSize	344
pANOVA	0.0442
s.dist	0.063
p.adjustANOVA	0.0589

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ASNS	15423
CSAD	15319
RPL38	15198
PHGDH	15187
RPL37	15167
ACAD8	15146
NNMT	15143
PHYKPL	15114
RPS26	14986
RPL36A	14937
RPL14	14922
MARS1	14908
PSME2	14893
CBS	14868
SEM1	14859
SUOX	14764
RPL35	14750
RPS15	14717
RPL18	14701
FAU	14693

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ASNS	15423
CSAD	15319
RPL38	15198
PHGDH	15187
RPL37	15167
ACAD8	15146
NNMT	15143
PHYKPL	15114
RPS26	14986
RPL36A	14937
RPL14	14922
MARS1	14908
PSME2	14893
CBS	14868
SEM1	14859
SUOX	14764
RPL35	14750
RPS15	14717
RPL18	14701
FAU	14693
RPL28	14692
RPL34	14680
AMT	14650
RPL31	14644
SAT1	14537
RPL23	14502
PSMB3	14498
FTCD	14496
RPL27A	14452
RPL12	14435
RPL24	14403
RPL29	14344
RPL19	14317
RPL32	14237
RPL17	14216
AADAT	14188
RPS27L	14115
GAMT	14112
RPLP2	14036
PSAT1	14035
NQO1	14023
RPL9	14000
RPS24	13945
PSMB10	13932
RPS18	13929
RPS21	13924
PSMB4	13901
RPS20	13888
ASL	13877
RPL4	13766
RPL13	13761
RPL36	13703
RPS16	13615
DIO2	13613
RPLP1	13585
GPT2	13513
NMRAL1	13500
PYCR2	13441
RPS7	13381
RPS28	13379
CHDH	13363
RPS15A	13339
SLC25A13	13332
RPL11	13315
SHMT1	13252
GPT	13220
MPST	13133
SLC25A12	13018
AMDHD1	12862
RPL6	12805
TPH1	12796
RPL37A	12745
HSD17B10	12668
HAAO	12631
GCDH	12537
RPS4X	12510
BHMT2	12466
RPS14	12432
PSMD6	12288
RPL35A	12114
RPS19	12039
PSMB7	11959
FAH	11909
CKMT1A	11765
KYNU	11755
RIDA	11695
UBA52	11501
PDHA1	11421
NAALAD2	11362
ALDH7A1	11350
RPS8	11338
PRODH	11281
RPS11	11194
RPS25	11123
RPL36AL	11075
TST	11063
PSMC4	10904
SCLY	10833
KMO	10817
RPL5	10785
PSPH	10781
CARNS1	10775
RPL26L1	10754
DUOX2	10675
PSMC3	10621
MTAP	10618
RPL26	10563
PSMD4	10510
GSTZ1	10128
RPL3L	10061
MAT1A	9896
IVD	9830
RPS6	9808
UROC1	9756
PSMC5	9697
SRM	9656
PIPOX	9613
SDSL	9499
IYD	9491
ACADSB	9405
DMGDH	9342
AZIN2	9279
PSMB9	9240
SLC25A10	9178
GNMT	8976
SARDH	8920
PCBD1	8578
HYKK	8577
CBSL	8352
PSTK	7998
PSMB1	7962
IDO2	7836
RPS13	7670
HGD	7654
SLC7A5	7232
RPL15	7111
SERINC2	7070
RPL39	6918
SDS	6898
INMT	6860
SLC6A12	6696
CPS1	6592
RPL8	6573
SECISBP2	6252
IDO1	6233
PSMA3	6151
ASPA	6085
TPO	5943
MCCC2	5772
RPL7A	5578
HIBADH	5460
BHMT	5271
TDO2	5214
TAT	5211
PAOX	5185
TPH2	5162
PXMP2	5099
AGMAT	4862
CTH	4819
RPS23	4723
ALDH4A1	4619
DIO1	4587
PSMB8	4550
RPL27	4534
PSME1	4473
SEPHS2	4386
HNMT	4366
APIP	4353
SRR	4292
AFMID	4226
GADL1	3839
DDO	3809
RPS3	3800
GRHPR	3632
RPS10	3602
MRI1	3424
PDHB	3379
BCAT2	3331
RPS17	3103
ECHS1	2857
AANAT	2583
CDO1	2375
HAL	2361
LIPT1	2208
PSMD13	2181
LIPT2	1989
PNMT	1914
DUOX1	1747
RPSA	1280
TDH	1137
HOGA1	1132
DBH	1120
RPL18A	1090
ARG1	959
CKM	866
SLC5A5	465
AGXT	438
BCKDHB	410
SLC3A2	386
RPL22L1	317
OCA2	183
ADI1	-133
AASS	-162
HPD	-316
LARS1	-324
FOLH1	-381
SERINC4	-438
AUH	-639
RPL30	-868
GLUD2	-879
IL4I1	-920
SLC25A21	-941
GLS2	-1013
DCT	-1043
RPS2	-1189
RPL22	-1380
HIBCH	-1474
RPS9	-1595
CKMT2	-1755
OAZ3	-2104
ASS1	-2390
PSMC2	-2444
RPS27	-2527
RIMKLB	-2583
SLC6A11	-2879
RPS12	-3070
CRYM	-3272
SEPSECS	-3295
CKB	-3661
GCAT	-3705
PSMB6	-3827
OAZ2	-3924
RPL10	-3951
GOT2	-4032
ASRGL1	-4197
KYAT1	-4227
MCCC1	-4252
PSMA4	-4415
LIAS	-4421
AIMP1	-4481
QARS1	-4520
GCSH	-4978
TXN2	-5068
RPS27A	-5160
RPL13A	-5167
DARS1	-5437
RPS29	-5438
RPL21	-5480
PSMD12	-5542
SLC25A44	-5546
OAZ1	-5574
NAGS	-5674
EEFSEC	-5718
RPS3A	-5741
GOT1	-5832
GATM	-5835
RPL23A	-5925
PSMA1	-6072
RPL3	-6101
PSMB2	-6126
KARS1	-6293
SARS1	-6479
TMLHE	-6593
PSMD9	-6748
RPLP0	-6852
AIMP2	-6895
PSMC6	-6903
PSMA6	-6980
AHCY	-7006
PSMD10	-7034
NDUFAB1	-7080
MTRR	-7086
RPS5	-7102
RPL41	-7130
EEF1E1	-7212
SLC6A8	-7254
QDPR	-7260
ACAT1	-7268
PSMD14	-7340
GSR	-7474
OAT	-7505
SLC44A1	-7527
RPL7	-7545
GLDC	-7581
ENOPH1	-7603
PSMB5	-7716
BCKDK	-7728
RIMKLA	-7736
IARS1	-7742
GLS	-7832
PSME3	-7994
PSMA2	-8025
PSMC1	-8097
PAPSS1	-8119
SMOX	-8210
GLUL	-8242
MTR	-8361
BCAT1	-8374
PSMA5	-8382
ALDH9A1	-8415
SMS	-8421
ADO	-8442
PPM1K	-8452
CARNMT1	-8486
PSMF1	-8503
DBT	-8524
RPL10A	-8562
ETHE1	-8655
NAT8L	-8752
PDHX	-8778
PSMD8	-8841
SLC36A4	-8876
SLC25A15	-8886
PSMD5	-8901
PSMD7	-8924
KYAT3	-8927
RARS1	-9117
DLST	-9257
DLAT	-9330
DLD	-9398
OGDH	-9550
PSMD11	-9552
PSMA7	-9678
PSMD3	-9689
RPL39L	-9883
BCKDHA	-9911
DHTKD1	-9940
AZIN1	-9949
ALDH6A1	-10077
PYCR1	-10208
EPRS1	-10220
PSMD2	-10307
PAPSS2	-10357
GLUD1	-10458
SERINC5	-10612
PSMD1	-10668
ALDH18A1	-10684
AMD1	-10911
TXNRD1	-10954
SERINC1	-10969
PSME4	-11141
SERINC3	-11143
ARG2	-11178
ODC1	-11252

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.8         
##  [49] XML_3.99-0.9           sass_0.4.0             dbplyr_2.1.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.2            later_1.3.0           
##  [58] AnnotationDbi_1.54.1   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.0            cachem_1.0.6           cli_3.2.0             
##  [64] generics_0.1.2         RSQLite_2.2.10         broom_0.7.12          
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.37             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.32.0        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.0         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.70.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] desc_1.4.1             lattice_0.20-45        Matrix_1.4-1          
##  [88] vctrs_0.3.8            pillar_1.7.0           lifecycle_1.0.1       
##  [91] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [94] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [97] KernSmooth_2.23-20     gridExtra_2.3          assertthat_0.2.1      
## [100] rprojroot_2.0.2        withr_2.5.0            GenomeInfoDbData_1.2.6
## [103] hms_1.1.1              grid_4.2.0             rmarkdown_2.13        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report