date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     x
## 5_8S_rRNA  13.3743116
## 7SK         8.2273688
## A1BG        6.5686329
## A1BG-AS1    2.0364019
## A1CF       -0.3353024
## A2M       -19.6842209
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 24
num_genes_in_profile 26163
duplicated_genes_present 0
num_profile_genes_in_sets 2727
num_profile_genes_not_in_sets 23436

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:
Gene sets metrics
Gene sets metrics
num_genesets 24
num_genesets_excluded 0
num_genesets_included 24

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 24 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Complex I biogenesis 57 1.31e-21 0.7300 1.57e-20
Respiratory electron transport 103 6.97e-25 0.5870 1.67e-23
Reduction of cytosolic Ca++ levels 12 2.03e-03 -0.5140 4.88e-03
Mitochondrial translation 96 3.34e-18 0.5130 2.67e-17
Mitochondrial iron-sulfur cluster biogenesis 13 4.21e-03 0.4580 9.18e-03
Cellular response to starvation 150 2.52e-17 0.4000 1.51e-16
Nucleotide biosynthesis 12 4.24e-02 -0.3380 6.10e-02
Mitochondrial protein import 64 1.09e-05 0.3180 3.28e-05
Stabilization of p53 53 3.29e-04 0.2850 8.76e-04
Phospholipid metabolism 192 1.80e-11 -0.2810 7.18e-11
Receptor Mediated Mitophagy 11 1.13e-01 -0.2760 1.46e-01
Mucopolysaccharidoses 11 1.20e-01 -0.2710 1.46e-01
Resolution of D-Loop Structures 33 1.61e-02 0.2420 2.71e-02
Metabolism of amino acids and derivatives 341 9.19e-13 0.2250 4.41e-12
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.54e-02 -0.1940 2.71e-02
Nervous system development 524 3.70e-10 -0.1600 1.27e-09
PTEN Regulation 140 1.69e-02 -0.1170 2.71e-02
Signaling by the B Cell Receptor (BCR) 106 4.32e-02 -0.1140 6.10e-02
Mitochondrial biogenesis 91 1.21e-01 -0.0939 1.46e-01
Gene Silencing by RNA 97 2.06e-01 -0.0743 2.35e-01
Mitophagy 28 6.08e-01 -0.0559 6.64e-01
Diseases of carbohydrate metabolism 30 7.13e-01 -0.0388 7.13e-01
Metabolism 1881 8.46e-03 -0.0364 1.69e-02
Oxidative Stress Induced Senescence 83 6.43e-01 -0.0294 6.71e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Complex I biogenesis 57 1.31e-21 0.7300 1.57e-20
Respiratory electron transport 103 6.97e-25 0.5870 1.67e-23
Reduction of cytosolic Ca++ levels 12 2.03e-03 -0.5140 4.88e-03
Mitochondrial translation 96 3.34e-18 0.5130 2.67e-17
Mitochondrial iron-sulfur cluster biogenesis 13 4.21e-03 0.4580 9.18e-03
Cellular response to starvation 150 2.52e-17 0.4000 1.51e-16
Nucleotide biosynthesis 12 4.24e-02 -0.3380 6.10e-02
Mitochondrial protein import 64 1.09e-05 0.3180 3.28e-05
Stabilization of p53 53 3.29e-04 0.2850 8.76e-04
Phospholipid metabolism 192 1.80e-11 -0.2810 7.18e-11
Receptor Mediated Mitophagy 11 1.13e-01 -0.2760 1.46e-01
Mucopolysaccharidoses 11 1.20e-01 -0.2710 1.46e-01
Resolution of D-Loop Structures 33 1.61e-02 0.2420 2.71e-02
Metabolism of amino acids and derivatives 341 9.19e-13 0.2250 4.41e-12
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.54e-02 -0.1940 2.71e-02
Nervous system development 524 3.70e-10 -0.1600 1.27e-09
PTEN Regulation 140 1.69e-02 -0.1170 2.71e-02
Signaling by the B Cell Receptor (BCR) 106 4.32e-02 -0.1140 6.10e-02
Mitochondrial biogenesis 91 1.21e-01 -0.0939 1.46e-01
Gene Silencing by RNA 97 2.06e-01 -0.0743 2.35e-01
Mitophagy 28 6.08e-01 -0.0559 6.64e-01
Diseases of carbohydrate metabolism 30 7.13e-01 -0.0388 7.13e-01
Metabolism 1881 8.46e-03 -0.0364 1.69e-02
Oxidative Stress Induced Senescence 83 6.43e-01 -0.0294 6.71e-01


Detailed Gene set reports



Complex I biogenesis

Complex I biogenesis
2
set Complex I biogenesis
setSize 57
pANOVA 1.31e-21
s.dist 0.73
p.adjustANOVA 1.57e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-ND2 14771
MT-ND3 14769
MT-ND1 14765
MT-ND4 14762
NDUFB1 14751
NDUFV2 14736
NDUFS5 14733
NDUFA7 14731
NDUFA1 14715
NDUFA2 14713
NDUFAF3 14700
NDUFA3 14672
NDUFA12 14636
MT-ND6 14633
NDUFB8 14627
MT-ND5 14600
NDUFB4 14596
NDUFA13 14559
NDUFA6 14489
NDUFA8 14488

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ND2 14771
MT-ND3 14769
MT-ND1 14765
MT-ND4 14762
NDUFB1 14751
NDUFV2 14736
NDUFS5 14733
NDUFA7 14731
NDUFA1 14715
NDUFA2 14713
NDUFAF3 14700
NDUFA3 14672
NDUFA12 14636
MT-ND6 14633
NDUFB8 14627
MT-ND5 14600
NDUFB4 14596
NDUFA13 14559
NDUFA6 14489
NDUFA8 14488
NDUFA11 14439
NDUFB9 14393
NDUFS8 14361
NDUFS3 14313
NDUFB10 14169
NDUFAF2 14161
NDUFB2 14098
NDUFB7 14030
NDUFC1 14023
NDUFS7 13997
NDUFV3 13890
COA1 13884
NDUFB6 13749
NDUFS6 13691
NDUFB3 13629
NDUFB11 13161
NDUFC2 12983
ACAD9 12951
NDUFA5 12663
NDUFAF6 12067
NDUFA9 11918
ECSIT 11668
TMEM126B 11368
NDUFAF5 11271
NDUFAF4 11158
NDUFAF1 11010
NDUFV1 10505
NDUFAF7 10405
NDUFAB1 10262
TMEM186 6002
NDUFS4 4585
TIMMDC1 -3430
NDUFA10 -4387
NDUFB5 -5177
NDUFS1 -7143
NUBPL -8112
NDUFS2 -10170


Respiratory electron transport

Respiratory electron transport
22
set Respiratory electron transport
setSize 103
pANOVA 6.97e-25
s.dist 0.587
p.adjustANOVA 1.67e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-CYB 14772
MT-ND2 14771
MT-ND3 14769
MT-CO2 14768
MT-CO1 14766
MT-ND1 14765
MT-CO3 14764
MT-ND4 14762
NDUFB1 14751
COX7B 14749
COX5B 14737
NDUFV2 14736
UQCRQ 14735
NDUFS5 14733
NDUFA7 14731
COX6B1 14720
NDUFA1 14715
NDUFA2 14713
NDUFAF3 14700
COX6A1 14689

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-CYB 14772
MT-ND2 14771
MT-ND3 14769
MT-CO2 14768
MT-CO1 14766
MT-ND1 14765
MT-CO3 14764
MT-ND4 14762
NDUFB1 14751
COX7B 14749
COX5B 14737
NDUFV2 14736
UQCRQ 14735
NDUFS5 14733
NDUFA7 14731
COX6B1 14720
NDUFA1 14715
NDUFA2 14713
NDUFAF3 14700
COX6A1 14689
NDUFA3 14672
NDUFA12 14636
MT-ND6 14633
NDUFB8 14627
COX4I1 14604
MT-ND5 14600
NDUFB4 14596
NDUFA13 14559
COX6C 14553
UQCRB 14511
UQCR10 14508
NDUFA6 14489
NDUFA8 14488
NDUFA11 14439
NDUFB9 14393
NDUFS8 14361
COX8A 14344
UQCRH 14321
NDUFS3 14313
COX7C 14187
NDUFB10 14169
NDUFAF2 14161
NDUFB2 14098
NDUFB7 14030
NDUFC1 14023
NDUFS7 13997
NDUFV3 13890
COA1 13884
NDUFB6 13749
NDUFS6 13691
NDUFB3 13629
NDUFB11 13161
UQCR11 13085
NDUFC2 12983
ACAD9 12951
NDUFA4 12919
NDUFA5 12663
COX20 12526
CYCS 12448
COX5A 12243
NDUFAF6 12067
NDUFA9 11918
COX16 11906
ECSIT 11668
TMEM126B 11368
NDUFAF5 11271
NDUFAF4 11158
CYC1 11099
SCO2 11075
NDUFAF1 11010
SURF1 10643
NDUFV1 10505
NDUFAF7 10405
COQ10A 10312
NDUFAB1 10262
TRAP1 10110
TACO1 9552
COX14 8403
SDHB 7106
COX19 6127
TMEM186 6002
NDUFS4 4585
COQ10B 1729
ETFB 630
ETFDH 383
UQCRC1 -1846
SDHD -2814
COX18 -2846
TIMMDC1 -3430
COX11 -4100
NDUFA10 -4387
NDUFB5 -5177
SDHC -5661
UQCRC2 -6128
SCO1 -6639
NDUFS1 -7143
ETFA -8019
NUBPL -8112
COX7A2L -8331
UQCRFS1 -8759
LRPPRC -9188
SDHA -10088
NDUFS2 -10170


Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels
20
set Reduction of cytosolic Ca++ levels
setSize 12
pANOVA 0.00203
s.dist -0.514
p.adjustANOVA 0.00488



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP2B4 -11368
ATP2A2 -11191
ATP2B1 -11033
ATP2A3 -9308
SRI -7727
SLC8A2 -7714
CALM1 -7050
SLC8A3 -6828
SLC8A1 -6632
ATP2B2 -2541
ATP2B3 8626
ATP2A1 12363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP2B4 -11368
ATP2A2 -11191
ATP2B1 -11033
ATP2A3 -9308
SRI -7727
SLC8A2 -7714
CALM1 -7050
SLC8A3 -6828
SLC8A1 -6632
ATP2B2 -2541
ATP2B3 8626
ATP2A1 12363


Mitochondrial translation

Mitochondrial translation
10
set Mitochondrial translation
setSize 96
pANOVA 3.34e-18
s.dist 0.513
p.adjustANOVA 2.67e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-RNR1 14757
MT-RNR2 14756
MRPS21 14723
GADD45GIP1 14716
MRPL22 14694
MRPL57 14691
MRPS15 14673
MRPL23 14669
MRPL24 14651
MRPL32 14605
MRPL34 14591
MRPL27 14560
MRPL41 14548
MRPL47 14467
MRPL18 14454
MRPL40 14415
MRPL21 14403
MRPL53 14391
MRPL52 14383
MRPL16 14353

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 14757
MT-RNR2 14756
MRPS21 14723
GADD45GIP1 14716
MRPL22 14694
MRPL57 14691
MRPS15 14673
MRPL23 14669
MRPL24 14651
MRPL32 14605
MRPL34 14591
MRPL27 14560
MRPL41 14548
MRPL47 14467
MRPL18 14454
MRPL40 14415
MRPL21 14403
MRPL53 14391
MRPL52 14383
MRPL16 14353
MRPS31 14348
MRPL20 14275
MRPL48 14272
MRPS26 14172
MRPL55 14150
MRPL2 14092
MRPS25 14089
MRPL38 14074
MRPS36 14067
MRPL54 14047
AURKAIP1 13994
CHCHD1 13966
MRPL17 13858
MRPL1 13720
TSFM 13693
MRPL11 13645
MRPL14 13565
MRPS17 13463
MRPS28 13425
MRPL35 13374
MRPL58 13364
MRPL12 13332
MRPL28 13215
MRPS18C 13071
MRPL51 12937
MRPL50 12558
MRRF 12542
MRPL43 12399
OXA1L 12210
MRPL39 12203
MRPS33 12160
PTCD3 12007
MRPS24 11761
MRPS9 11727
MRPS22 11691
MTIF3 11496
TUFM 11439
MRPS34 11346
MRPS16 11223
MRPS14 10560
MRPL46 10430
MRPS5 10168
MRPS7 9871
MRPL36 9753
MRPL19 9589
MRPL42 8812
MRPL15 8705
ERAL1 7930
MRPS23 4907
MRPS12 4244
MRPL33 3491
MRPS18B 2531
MTFMT 2148
MRPL4 2003
MRPL13 1910
DAP3 -598
MRPL44 -1217
MRPS18A -1316
MRPL3 -1752
MRPL9 -2012
MTIF2 -2264
MRPL30 -2298
MRPS11 -2590
MTRF1L -3489
MRPL10 -4070
MRPS6 -4671
MRPS35 -5168
MRPS10 -5681
MRPL49 -6147
MRPS30 -7550
MRPL45 -8016
MRPS27 -8491
MRPL37 -8801
MRPS2 -9349
GFM2 -9775
GFM1 -9794


Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis
8
set Mitochondrial iron-sulfur cluster biogenesis
setSize 13
pANOVA 0.00421
s.dist 0.458
p.adjustANOVA 0.00918



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC25A37 14540
SLC25A28 14264
GLRX5 13304
FDX2 12267
LYRM4 11783
ISCU 11686
FDX1 9808
HSCB 8979
FXN 7427
ISCA2 5842
FDXR -11
NFS1 -4918
ISCA1 -5073

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A37 14540
SLC25A28 14264
GLRX5 13304
FDX2 12267
LYRM4 11783
ISCU 11686
FDX1 9808
HSCB 8979
FXN 7427
ISCA2 5842
FDXR -11
NFS1 -4918
ISCA1 -5073


Cellular response to starvation

Cellular response to starvation
1
set Cellular response to starvation
setSize 150
pANOVA 2.52e-17
s.dist 0.4
p.adjustANOVA 1.51e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL38 14728
RPL14 14725
RPL37 14722
RPL31 14719
RPS26 14702
FAU 14690
RPL35 14685
RPS20 14683
RPL27A 14639
RPS24 14622
RPS21 14610
RPL36A 14597
RPLP2 14587
RPL34 14584
RPL24 14583
RPL12 14580
RPS15A 14577
RPS18 14572
RPL32 14571
RPS7 14564

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL38 14728
RPL14 14725
RPL37 14722
RPL31 14719
RPS26 14702
FAU 14690
RPL35 14685
RPS20 14683
RPL27A 14639
RPS24 14622
RPS21 14610
RPL36A 14597
RPLP2 14587
RPL34 14584
RPL24 14583
RPL12 14580
RPS15A 14577
RPS18 14572
RPL32 14571
RPS7 14564
RPL28 14550
RPS16 14529
RPS11 14523
RPL23 14510
RPL29 14503
RPL19 14499
RPL17 14497
RPS15 14496
RPS19 14476
RPL36 14456
ATP6V1F 14441
ATP6V1B1 14399
RPL9 14394
RPL18 14388
RPL35A 14377
RPL26L1 14358
RPS27L 14338
RPS8 14333
RPLP1 14319
RPL6 14318
RPL36AL 14290
RPS25 14278
RPL37A 14263
RPL26 14246
CEBPB 14244
RPS13 14240
RPL13 14186
NPRL2 14149
RPL4 14145
RPS28 14071
ATP6V0E1 14022
RPS14 14014
RPS6 13991
ITFG2 13984
RPL11 13968
ASNS 13935
RPS4X 13824
RPL22L1 13806
ATP6V0B 13760
RPL15 13737
RPS3 13719
TCIRG1 13666
RPL5 13658
RPL39 13544
ATF4 13530
RPL18A 13507
RPS23 13488
RPL7A 13286
UBA52 13217
RPS17 13209
RPL27 13203
RPS12 13178
RPSA 13154
ATP6V1G1 12943
RPS27 12843
RPL30 12665
LAMTOR5 12649
DDIT3 12553
LAMTOR4 12402
WDR59 12236
RPS10 12226
RPL8 11881
ATP6V1C2 11831
KPTN 11801
RPS9 11743
LAMTOR2 11734
ATP6V0C 11576
RPL22 11069
RPS29 10608
RPS2 10438
RPL3L 9364
ATP6V0E2 8459
RPL13A 8281
CEBPG 7841
SZT2 7818
RPS27A 7697
LAMTOR3 7401
RPS3A 6205
RPL21 6069
RRAGB 5473
NPRL3 5128
RHEB 5078
ATP6V0D2 3408
RPL10 1774
ATP6V1G2 1620
ATP6V1E2 906
ATP6V1D 265
ATP6V1H -510
ATP6V1E1 -953
DEPDC5 -3711
SESN2 -3846
SESN1 -4278
FLCN -4342
ATF3 -4455
RPL3 -4637
RPTOR -4928
MLST8 -4999
EIF2S3 -5124
RPL23A -5359
TRIB3 -5654
SEH1L -5755
MTOR -6010
RPL41 -6176
EIF2S2 -6191
RPL39L -6371
SLC38A9 -7228
RPLP0 -7433
WDR24 -7523
RRAGA -7783
LAMTOR1 -7824
EIF2AK4 -7868
MIOS -7959
RPS5 -8067
IMPACT -8229
RPL10A -8314
ATP6V0D1 -8315
GCN1 -8359
ATP6V1C1 -8502
BMT2 -8538
SEC13 -8748
ATP6V1A -8862
EIF2S1 -8876
RPL7 -8891
RRAGD -9212
ATF2 -9391
FNIP1 -9444
FNIP2 -9808
RRAGC -9892
ATP6V1B2 -9950
SH3BP4 -10539


Nucleotide biosynthesis

Nucleotide biosynthesis
14
set Nucleotide biosynthesis
setSize 12
pANOVA 0.0424
s.dist -0.338
p.adjustANOVA 0.061



Top enriched genes

Top 20 genes
GeneID Gene Rank
CAD -10912
PPAT -10038
IMPDH2 -9850
GART -9647
PAICS -7887
GMPS -7594
IMPDH1 -5600
UMPS -3218
ATIC 1882
ADSL 6016
PFAS 11942
DHODH 12098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAD -10912
PPAT -10038
IMPDH2 -9850
GART -9647
PAICS -7887
GMPS -7594
IMPDH1 -5600
UMPS -3218
ATIC 1882
ADSL 6016
PFAS 11942
DHODH 12098


Mitochondrial protein import

Mitochondrial protein import
9
set Mitochondrial protein import
setSize 64
pANOVA 1.09e-05
s.dist 0.318
p.adjustANOVA 3.28e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
COX17 14695
CHCHD10 14643
PAM16 14632
NDUFB8 14627
ATP5MC1 14573
TOMM5 14468
TIMM8B 14342
TAZ 14188
TIMM23 14146
TIMM44 14077
TIMM50 14036
DNAJC19 14002
TOMM40 13789
MTX1 13572
TIMM10 13389
TIMM13 13320
CMC2 13312
COA6 13310
TOMM6 13247
TIMM17B 12966

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COX17 14695
CHCHD10 14643
PAM16 14632
NDUFB8 14627
ATP5MC1 14573
TOMM5 14468
TIMM8B 14342
TAZ 14188
TIMM23 14146
TIMM44 14077
TIMM50 14036
DNAJC19 14002
TOMM40 13789
MTX1 13572
TIMM10 13389
TIMM13 13320
CMC2 13312
COA6 13310
TOMM6 13247
TIMM17B 12966
BCS1L 12931
MTX2 12381
COQ2 12329
TIMM9 11804
CHCHD7 11712
COA4 11514
TIMM21 11349
CYC1 11099
CHCHD5 10959
IDH3G 10660
CMC4 9909
TOMM22 9343
TIMM22 9101
HSCB 8979
PMPCA 7860
CHCHD4 7856
HSPA9 7805
FXN 7427
SLC25A12 6313
COX19 6127
TIMM10B 5140
HSPD1 5046
GRPEL1 3442
TIMM8A -152
CHCHD2 -428
VDAC1 -438
SLC25A4 -936
SLC25A6 -1146
GFER -2441
ACO2 -2479
SLC25A13 -4204
TOMM7 -5586
SAMM50 -6035
GRPEL2 -6288
LDHD -6481
CHCHD3 -7319
PITRM1 -7532
PMPCB -7819
TIMM17A -8000
ATP5F1B -9117
ATP5F1A -9726
TOMM70 -9823
TOMM20 -10241
CS -10647


Stabilization of p53

Stabilization of p53
24
set Stabilization of p53
setSize 53
pANOVA 0.000329
s.dist 0.285
p.adjustANOVA 0.000876



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEM1 14696
PSMB3 14666
PSMB4 14586
PSME2 14457
PSMC4 14302
PSMA3 14148
PSMB1 14066
PSMB7 14048
CHEK2 13953
PSMC3 13913
PSMD6 13813
PSMD13 13724
PSMC5 13624
UBB 13607
PSME1 13459
PSMD4 13334
PSMB10 13241
UBA52 13217
PSMA4 13022
PSMB8 12723

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEM1 14696
PSMB3 14666
PSMB4 14586
PSME2 14457
PSMC4 14302
PSMA3 14148
PSMB1 14066
PSMB7 14048
CHEK2 13953
PSMC3 13913
PSMD6 13813
PSMD13 13724
PSMC5 13624
UBB 13607
PSME1 13459
PSMD4 13334
PSMB10 13241
UBA52 13217
PSMA4 13022
PSMB8 12723
PSMC2 12636
PSMB6 12465
PSMB9 12294
PSMA1 12138
TP53 11698
MDM4 11574
PSMA6 10525
PSMB2 10501
PSMD12 10294
PSMD14 9962
UBC 8359
RPS27A 7697
PSMD10 1419
PSMA5 902
PSMC6 758
PSMB5 -3070
PSMD9 -3447
PSMC1 -3916
PSMF1 -4471
PSMA2 -4532
PSMD3 -4900
MDM2 -5708
ATM -6114
PSMD7 -6145
PSMD8 -6628
PSMA7 -7709
PSME3 -7915
PSMD5 -8141
PSMD11 -8620
PHF20 -9644
PSMD2 -10480
PSMD1 -10543
PSME4 -10945


Phospholipid metabolism

Phospholipid metabolism
17
set Phospholipid metabolism
setSize 192
pANOVA 1.8e-11
s.dist -0.281
p.adjustANOVA 7.18e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTMR12 -11240
LPIN2 -11189
SBF2 -11155
CPNE3 -11054
OSBPL10 -11025
PITPNM1 -11013
MGLL -10706
CSNK2A1 -10688
PLEKHA2 -10533
RAB14 -10469
CSNK2A2 -10434
PIKFYVE -10408
PI4KB -10391
PIK3CB -10352
OSBPL8 -10344
MIGA1 -10329
MTMR3 -10288
PLEKHA1 -10277
SELENOI -10031
LCLAT1 -9976

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTMR12 -11240
LPIN2 -11189
SBF2 -11155
CPNE3 -11054
OSBPL10 -11025
PITPNM1 -11013
MGLL -10706
CSNK2A1 -10688
PLEKHA2 -10533
RAB14 -10469
CSNK2A2 -10434
PIKFYVE -10408
PI4KB -10391
PIK3CB -10352
OSBPL8 -10344
MIGA1 -10329
MTMR3 -10288
PLEKHA1 -10277
SELENOI -10031
LCLAT1 -9976
GPD2 -9923
PLD1 -9865
CDS2 -9752
PIK3CA -9701
DDHD1 -9692
PIK3R1 -9670
PIK3CD -9626
PIK3C2A -9621
PIP4K2C -9600
PLEKHA8 -9583
PIK3R4 -9524
MTMR2 -9438
PLA2G4A -9352
LPGAT1 -9323
PIP5K1A -9280
AGPAT3 -9226
DDHD2 -9129
STARD7 -9124
MTMR6 -9027
INPP4A -8999
MTMR4 -8979
AGPAT5 -8978
CEPT1 -8905
GPAT3 -8758
PNPLA8 -8716
ETNK2 -8693
AGPAT1 -8683
HADHB -8672
PTDSS1 -8645
PTEN -8635
OCRL -8617
RAB5A -8585
PNPLA3 -8509
INPP5F -8487
PITPNB -8406
PCTP -8395
SLC44A1 -8297
GPAM -8280
MBOAT2 -8226
MTMR9 -8214
PIP4K2A -8192
HADHA -8132
PLEKHA5 -8093
PLD2 -8038
PIK3C3 -7967
ABHD4 -7944
PTPN13 -7935
MTM1 -7910
VAC14 -7876
MBOAT7 -7802
SACM1L -7768
PI4K2B -7570
SBF1 -7507
PLA2G12A -7505
SLC44A5 -7363
MTMR1 -7109
LPCAT2 -7006
CDIPT -6957
TNFAIP8L1 -6914
PI4K2A -6857
PIP5K1B -6840
ARF3 -6750
GPAT4 -6685
SLC44A2 -6531
MTMR10 -6497
INPP5D -6437
PLEKHA3 -6412
PIK3C2B -6354
PLA2R1 -6284
SYNJ1 -6174
PLA2G4C -6036
PI4KA -5998
LPCAT1 -5970
PIK3R2 -5950
GDPD1 -5923
OSBPL5 -5861
PCYT1A -5835
PGS1 -5826
LPIN1 -5823
GDE1 -5702
ARF1 -5663
FIG4 -5627
SYNJ2 -5589
TNFAIP8 -5455
ACP6 -5288
PIK3CG -5212
PLA2G15 -5190
CHPT1 -5137
PLAAT1 -5010
PNPLA6 -4995
ETNK1 -4852
PITPNM2 -4781
MBOAT1 -4456
INPPL1 -4429
GDPD5 -4344
RAB4A -4268
PLD3 -3725
PIK3R3 -3558
CHAT -3281
CRLS1 -3175
PNPLA2 -3045
PLD6 -2947
SLC44A3 -2884
CDS1 -2783
PIK3R6 -2566
PIP5K1C -1077
PLA2G4E -487
ACHE -47
PLBD1 41
PIK3R5 115
PIP4K2B 1237
INPP4B 1266
PLA1A 1350
PCYT1B 2329
PITPNM3 2914
MFSD2A 3872
TNFAIP8L3 4426
ENPP6 4952
ETNPPL 5323
PLB1 5405
PLA2G4F 5416
PLA2G4D 5461
PLA2G10 5551
PISD 5579
PLA2G2D 5692
MTMR7 5748
LIPH 6059
INPP5K 6081
GPD1L 6210
PTDSS2 6491
GNPAT 6592
GPD1 7439
INPP5J 7498
GPAT2 7550
PLEKHA6 8898
PLA2G5 9011
PLD4 9338
MTMR14 9437
PEMT 9679
PLAAT2 9730
PHOSPHO1 10364
LPCAT3 10449
LPIN3 10654
DGAT2 10818
AGPAT4 10970
INPP5E 11120
PNPLA7 11395
STARD10 11676
BCHE 11796
DGAT1 11969
GDPD3 11988
PLEKHA4 12027
AGK 12094
AGPAT2 12108
TMEM86B 12218
ABHD3 12772
RUFY1 13124
LPCAT4 13214
MIGA2 13307
CPNE1 13546
CSNK2B 13594
CPNE7 13597
PTPMT1 13886
PLAAT4 13970
PCYT2 14052
GPCPD1 14058
CHKA 14168
PLAAT3 14176
TAZ 14188
PLA2G6 14315
CHKB 14366
PLA2G4B 14652


Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
19
set Receptor Mediated Mitophagy
setSize 11
pANOVA 0.113
s.dist -0.276
p.adjustANOVA 0.146



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2A1 -10688
CSNK2A2 -10434
ULK1 -7444
SRC -7386
ATG5 -7330
ATG12 -5792
PGAM5 -4577
MAP1LC3B -1844
MAP1LC3A 10182
FUNDC1 10637
CSNK2B 13594

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2A1 -10688
CSNK2A2 -10434
ULK1 -7444
SRC -7386
ATG5 -7330
ATG12 -5792
PGAM5 -4577
MAP1LC3B -1844
MAP1LC3A 10182
FUNDC1 10637
CSNK2B 13594


Mucopolysaccharidoses

Mucopolysaccharidoses
12
set Mucopolysaccharidoses
setSize 11
pANOVA 0.12
s.dist -0.271
p.adjustANOVA 0.146



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNS -11227
IDS -10234
GLB1 -9342
ARSB -7596
GALNS -6472
NAGLU -5401
HGSNAT -4061
HYAL1 607
SGSH 9716
GUSB 10432
IDUA 13198

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNS -11227
IDS -10234
GLB1 -9342
ARSB -7596
GALNS -6472
NAGLU -5401
HGSNAT -4061
HYAL1 607
SGSH 9716
GUSB 10432
IDUA 13198


Resolution of D-Loop Structures

Resolution of D-Loop Structures
21
set Resolution of D-Loop Structures
setSize 33
pANOVA 0.0161
s.dist 0.242
p.adjustANOVA 0.0271



Top enriched genes

Top 20 genes
GeneID Gene Rank
XRCC3 14551
EME1 14387
DNA2 13599
EME2 13492
RTEL1 13471
SLX1A 13434
MUS81 13344
BLM 13164
GEN1 13117
XRCC2 13080
MRE11 12948
RAD51C 12525
RMI2 12235
EXO1 11792
RAD51AP1 9194
RBBP8 7690
RAD51D 7061
BRCA1 6969
BRIP1 4063
SLX4 2747

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
XRCC3 14551
EME1 14387
DNA2 13599
EME2 13492
RTEL1 13471
SLX1A 13434
MUS81 13344
BLM 13164
GEN1 13117
XRCC2 13080
MRE11 12948
RAD51C 12525
RMI2 12235
EXO1 11792
RAD51AP1 9194
RBBP8 7690
RAD51D 7061
BRCA1 6969
BRIP1 4063
SLX4 2747
KAT5 731
RAD51B -2224
RAD51 -2938
SPIDR -3800
BRCA2 -3866
RMI1 -4406
PALB2 -5244
BARD1 -5351
WRN -5917
ATM -6114
TOP3A -6513
RAD50 -8035
NBN -9069


Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives
6
set Metabolism of amino acids and derivatives
setSize 341
pANOVA 9.19e-13
s.dist 0.225
p.adjustANOVA 4.41e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL38 14728
RPL14 14725
RPL37 14722
RPL31 14719
RPS26 14702
SEM1 14696
FAU 14690
RPL35 14685
RPS20 14683
PSMB3 14666
RPL27A 14639
RPS24 14622
RPS21 14610
RPL36A 14597
RPLP2 14587
PSMB4 14586
RPL34 14584
RPL24 14583
RPL12 14580
RPS15A 14577

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL38 14728
RPL14 14725
RPL37 14722
RPL31 14719
RPS26 14702
SEM1 14696
FAU 14690
RPL35 14685
RPS20 14683
PSMB3 14666
RPL27A 14639
RPS24 14622
RPS21 14610
RPL36A 14597
RPLP2 14587
PSMB4 14586
RPL34 14584
RPL24 14583
RPL12 14580
RPS15A 14577
RPS18 14572
RPL32 14571
RPS7 14564
RPL28 14550
RPS16 14529
RPS11 14523
RPL23 14510
RPL29 14503
RPL19 14499
RPL17 14497
RPS15 14496
RPS19 14476
PSME2 14457
RPL36 14456
NNMT 14452
RPL9 14394
RPL18 14388
RPL35A 14377
RPL26L1 14358
RPS27L 14338
RPS8 14333
RPLP1 14319
RPL6 14318
CSAD 14316
PSMC4 14302
RPL36AL 14290
RPS25 14278
RPL37A 14263
RPL26 14246
RPS13 14240
RPL13 14186
PSMA3 14148
RPL4 14145
PHGDH 14137
RPS28 14071
PSMB1 14066
PSMB7 14048
RPS14 14014
RPS6 13991
RPL11 13968
ASNS 13935
PSMC3 13913
PYCR2 13854
RPS4X 13824
GAMT 13815
PSMD6 13813
RPL22L1 13806
SHMT1 13776
RPL15 13737
PDHB 13736
PSMD13 13724
RPS3 13719
RPL5 13658
NQO1 13648
PSMC5 13624
MPST 13602
NMRAL1 13593
RPL39 13544
HSD17B10 13513
RPL18A 13507
RPS23 13488
CKMT1A 13484
SRM 13483
PSME1 13459
PDHA1 13423
PSMD4 13334
RPL7A 13286
PSMB10 13241
UBA52 13217
RPS17 13209
RPL27 13203
RPS12 13178
RPSA 13154
PSAT1 13153
ACAD8 13049
PSMA4 13022
RIDA 12911
RPS27 12843
ECHS1 12805
CKB 12760
GCAT 12733
CBS 12729
PSMB8 12723
ALDH7A1 12669
RPL30 12665
PSMC2 12636
MARS1 12544
PSMB6 12465
SLC25A10 12439
PSMB9 12294
SCLY 12232
RPS10 12226
TST 12222
PSMA1 12138
FTCD 12109
RPL8 11881
BHMT2 11779
RPS9 11743
APIP 11512
GCSH 11466
GCDH 11456
MRI1 11452
HYKK 11407
KARS1 11331
SUOX 11196
RPL22 11069
PSTK 10855
TPH1 10734
GPT 10675
HAAO 10666
ADI1 10625
RPS29 10608
PCBD1 10604
PSMA6 10525
PSMB2 10501
PRODH 10458
RPS2 10438
AMT 10435
FAH 10338
DIO2 10325
CHDH 10303
PSMD12 10294
NDUFAB1 10262
GSTZ1 10220
SAT1 10087
OAZ1 10041
HIBADH 10015
PSMD14 9962
GRHPR 9810
BCAT2 9595
NAALAD2 9503
AFMID 9384
RPL3L 9364
TPH2 9252
GOT1 9229
GPT2 8933
IDO1 8830
TPO 8748
AADAT 8658
SRR 8585
PSPH 8385
RPL13A 8281
KMO 8135
KYNU 8048
MTAP 7800
RPS27A 7697
AMDHD1 7261
CPS1 7256
PNMT 7066
TDO2 6977
BHMT 6861
SLC25A12 6313
HOGA1 6312
RPS3A 6205
HPD 6118
ASL 6077
LIAS 6071
RPL21 6069
GNMT 6067
CBSL 6015
IYD 5993
AUH 5965
LIPT2 5927
HGD 5371
PXMP2 5356
ACADSB 5287
DARS1 5236
HAL 5227
PHYKPL 5049
SLC5A5 4947
SDSL 4704
TDH 4564
HNMT 4278
AZIN2 4266
TXN2 3772
UROC1 3745
SDS 3701
DMGDH 3584
IDO2 3288
MAT1A 3243
GLS2 3059
LIPT1 2883
CRYM 2820
KYAT1 2571
CGA 2473
DCT 2256
AIMP1 2062
ENOPH1 1995
ASPA 1780
RPL10 1774
PSMD10 1419
SLC6A12 1324
EEF1E1 1190
HIBCH 1060
GOT2 920
PSMA5 902
PSMC6 758
AHCY 685
ASRGL1 636
TAT 484
FOLH1 481
CKM 416
RIMKLB 374
AGMAT 354
CARNS1 352
BCKDHB 169
DDO -148
DUOX2 -284
SEPHS2 -372
SLC25A21 -374
GADL1 -1068
ARG1 -1253
DBH -1622
MCCC2 -1881
ASS1 -1956
CKMT2 -1996
SMS -2082
AIMP2 -2121
SARDH -2608
PIPOX -2759
OAZ3 -3034
PSMB5 -3070
DUOX1 -3261
PSMD9 -3447
SLC3A2 -3537
EEFSEC -3593
SLC6A11 -3627
OAT -3707
CTH -3820
ALDH4A1 -3892
PSMC1 -3916
PAPSS1 -4029
SLC25A13 -4204
ACAT1 -4340
SERINC2 -4401
PSMF1 -4471
IL4I1 -4498
IVD -4522
PSMA2 -4532
GLUD2 -4612
RPL3 -4637
OAZ2 -4838
PSMD3 -4900
SLC7A5 -4941
PDHX -5030
INMT -5054
GSR -5098
SEPSECS -5198
PAOX -5267
RPL23A -5359
OCA2 -5431
AANAT -5938
LARS1 -5961
PSMD7 -6145
RPL41 -6176
QDPR -6222
ETHE1 -6241
SLC25A15 -6321
ALDH9A1 -6360
RPL39L -6371
SECISBP2 -6619
PSMD8 -6628
QARS1 -6790
MCCC1 -6892
BCKDK -7009
SLC25A44 -7044
GATM -7197
CARNMT1 -7305
RARS1 -7354
RPLP0 -7433
AASS -7440
GLDC -7522
PSMA7 -7709
TMLHE -7751
PPM1K -7791
DLAT -7847
PSME3 -7915
OGDH -7930
RPS5 -8067
PSMD5 -8141
SLC44A1 -8297
RPL10A -8314
DLD -8396
ALDH6A1 -8433
DHTKD1 -8474
MTRR -8615
PSMD11 -8620
DBT -8750
SLC36A4 -8770
ODC1 -8817
RPL7 -8891
GLS -8911
NAGS -9087
RIMKLA -9096
SLC6A8 -9160
KYAT3 -9254
ADO -9258
NAT8L -9452
BCAT1 -9473
SARS1 -9523
IARS1 -9672
MTR -9844
AMD1 -10017
GLUL -10037
TXNRD1 -10057
BCKDHA -10142
SERINC5 -10225
GLUD1 -10420
PSMD2 -10480
PSMD1 -10543
ALDH18A1 -10575
AZIN1 -10652
SERINC3 -10820
PAPSS2 -10873
DLST -10933
PSME4 -10945
EPRS1 -10997
SERINC1 -11029
PYCR1 -11114
SMOX -11123
ARG2 -11135


Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
18
set Pyruvate metabolism and Citric Acid (TCA) cycle
setSize 52
pANOVA 0.0154
s.dist -0.194
p.adjustANOVA 0.0271



Top enriched genes

Top 20 genes
GeneID Gene Rank
DLST -10933
NNT -10892
CS -10647
ME2 -10188
SDHA -10088
SLC16A1 -9961
PDP1 -9519
L2HGDH -9505
PDK1 -9327
LDHA -9307
SUCLG2 -9019
PDK3 -8900
MDH2 -8870
PDP2 -8640
DLD -8396
PDPR -8205
OGDH -7930
DLAT -7847
SUCLA2 -7753
ME1 -7590

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLST -10933
NNT -10892
CS -10647
ME2 -10188
SDHA -10088
SLC16A1 -9961
PDP1 -9519
L2HGDH -9505
PDK1 -9327
LDHA -9307
SUCLG2 -9019
PDK3 -8900
MDH2 -8870
PDP2 -8640
DLD -8396
PDPR -8205
OGDH -7930
DLAT -7847
SUCLA2 -7753
ME1 -7590
IDH2 -7278
SLC16A3 -6554
RXRA -6110
SDHC -5661
PDHX -5030
IDH3B -4653
PDK4 -3900
LDHAL6B -3336
IDH3A -3167
SDHD -2814
ACO2 -2479
VDAC1 -438
PDK2 2295
LDHB 2415
GLO1 5419
LDHAL6A 6228
SDHB 7106
PPARD 7885
FAHD1 9129
ME3 9212
ADHFE1 9294
MPC2 9395
D2HGDH 9528
GSTZ1 10220
IDH3G 10660
SUCLG1 12157
FH 12650
MPC1 12954
HAGH 13149
PDHA1 13423
PDHB 13736
BSG 14131


Nervous system development

Nervous system development
13
set Nervous system development
setSize 524
pANOVA 3.7e-10
s.dist -0.16
p.adjustANOVA 1.27e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITGB3 -11388
MMP9 -11376
HSPA8 -11361
ITGA5 -11344
GDNF -11341
NRP2 -11337
LAMC1 -11329
SEMA7A -11325
ITGB1 -11317
ITGA2 -11315
AGRN -11307
VLDLR -11306
CLTC -11303
L1CAM -11291
ANK3 -11224
EGFR -11195
MET -11149
ROCK1 -11131
ITGAV -11113
MSN -11098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGB3 -11388
MMP9 -11376
HSPA8 -11361
ITGA5 -11344
GDNF -11341
NRP2 -11337
LAMC1 -11329
SEMA7A -11325
ITGB1 -11317
ITGA2 -11315
AGRN -11307
VLDLR -11306
CLTC -11303
L1CAM -11291
ANK3 -11224
EGFR -11195
MET -11149
ROCK1 -11131
ITGAV -11113
MSN -11098
MAP2K1 -11091
SPTBN1 -11088
PLXNA1 -11087
AP2B1 -11086
YAP1 -11062
PRKAR2A -11045
SEMA5A -11014
MAPK1 -11008
ALCAM -10987
PSME4 -10945
SDCBP -10905
NUMB -10903
DOCK1 -10879
MYO10 -10875
GSK3B -10857
WWTR1 -10838
ARHGEF12 -10835
GRB10 -10792
ROBO1 -10780
RGMB -10779
NRP1 -10775
PRNP -10766
SREBF2 -10761
TEAD1 -10726
ARHGAP35 -10705
CSNK2A1 -10688
UTRN -10676
HMGCR -10672
RASA1 -10669
ITGA1 -10654
PSEN1 -10651
GRB2 -10626
NGEF -10547
PSMD1 -10543
RHOC -10531
EFNB3 -10525
EFNB2 -10518
PABPC1 -10508
PRKCA -10498
PSMD2 -10480
PFN2 -10473
CSNK2A2 -10434
LAMB1 -10431
ADAM10 -10423
EIF4G1 -10389
PAK2 -10387
CASC3 -10370
GSPT1 -10362
PIK3CB -10352
CAP1 -10303
EPHB1 -10276
CD24 -10271
PTK2 -10250
MYH9 -10245
YES1 -10243
IRS2 -10196
CUL2 -10195
LAMA1 -10193
UNC5B -10182
TLN1 -10156
ABL2 -10119
SPTBN2 -10102
NCK1 -10095
ITGA9 -10091
PMP22 -10084
DPYSL3 -10081
EPHB4 -10074
SOS1 -10023
RHOA -10019
KALRN -10006
FLRT3 -10000
ARPC2 -9995
PLXNA4 -9947
SLIT3 -9932
NTN1 -9908
APH1A -9880
PAK1 -9837
DLG1 -9827
NRAS -9826
APH1B -9782
ROCK2 -9734
PRKACB -9716
RDX -9708
PIK3CA -9701
SIAH2 -9685
PIK3R1 -9670
PIK3CD -9626
EFNA5 -9617
RPS6KA3 -9604
COL6A1 -9601
ETF1 -9598
PITPNA -9565
SHC1 -9564
PTPN11 -9492
ABLIM3 -9474
DCC -9461
FRS2 -9420
SOS2 -9419
RANBP9 -9410
MYH10 -9382
MAPK3 -9373
DLG4 -9367
SHTN1 -9359
NEO1 -9329
SLIT2 -9320
NRCAM -9237
HSP90AB1 -9216
ACTR3 -9211
RPS6KA2 -9203
POU3F2 -9197
CYP51A1 -9173
CACNA1H -9115
ACTR2 -9110
COL6A2 -8998
ABL1 -8987
ACTG1 -8976
RPL7 -8891
COL6A3 -8887
CLASP2 -8882
GAB2 -8835
USP33 -8792
UNC5A -8765
CREB1 -8757
EPHA4 -8752
KRAS -8721
WASL -8689
DAG1 -8675
SCD5 -8663
ITSN1 -8639
ARPC5 -8628
PSMD11 -8620
PRX -8591
ENAH -8572
CDC42 -8552
NAB1 -8447
MMP2 -8371
SEMA3A -8361
DOK1 -8356
SH3KBP1 -8328
GAB1 -8325
RPL10A -8314
UNC5D -8282
AP2A1 -8236
PTPRA -8185
PSMD5 -8141
RPS5 -8067
RELN -8041
GPC1 -8024
SHANK3 -8021
VAV2 -8001
NELL2 -7982
FGFR1 -7978
ST8SIA4 -7969
SHC3 -7962
PSME3 -7915
KCNQ3 -7885
RPS6KA1 -7863
NTN4 -7805
SEMA6A -7756
PSMA7 -7709
SEMA6D -7641
MAPK14 -7640
HSP90AA1 -7636
ARHGEF28 -7575
SPTAN1 -7534
EZR -7524
PAK3 -7519
DLG3 -7499
RPLP0 -7433
CXCR4 -7417
SRC -7386
UPF2 -7271
SMARCA4 -7247
PPP3CB -7240
ADGRG6 -7205
SRGAP1 -7192
EFNB1 -7179
RPS6KA5 -7165
PLXNA2 -7011
PAK4 -6964
TRPC1 -6909
SRGAP2 -6882
SRGAP3 -6878
TRIO -6874
GSPT2 -6829
MYO9B -6815
HDAC2 -6806
CNTN1 -6789
ARPC1B -6778
EPHB2 -6763
SCN5A -6748
GFRA2 -6737
NCK2 -6728
DPYSL2 -6719
VASP -6675
PLXNB3 -6669
PSMD8 -6628
TIAM1 -6521
EIF4A3 -6445
CAP2 -6439
NCBP2 -6383
RPL39L -6371
SLIT1 -6365
GAP43 -6332
ANK2 -6293
AP2M1 -6283
EPHA2 -6278
CLTCL1 -6202
RPL41 -6176
PSMD7 -6145
LYN -6130
ZSWIM8 -6088
CDK5R1 -5992
ERBB2 -5951
PIK3R2 -5950
MAPK8 -5949
COL4A2 -5846
SDC2 -5839
RNPS1 -5716
DNM2 -5707
LHX4 -5705
DOK6 -5687
ABLIM1 -5575
CNTNAP1 -5406
RPL23A -5359
NCBP1 -5336
CLTA -5330
ARHGEF11 -5172
AP2A2 -5147
SH3GL2 -5090
MYL12A -4922
PSMD3 -4900
PRKCQ -4886
LHX9 -4843
PLXNC1 -4832
CLASP1 -4775
COL6A5 -4766
GRIN2B -4673
MAPK7 -4670
RPL3 -4637
PSMA2 -4532
CACNA1C -4487
DSCAML1 -4474
PSMF1 -4471
PLXND1 -4393
NCSTN -4379
LAMA2 -4267
AGAP2 -4251
SCN1B -4248
DNM3 -4205
PAK5 -4128
EFNA1 -4097
ARHGAP39 -4073
EGR2 -4050
SIAH1 -4010
GIT1 -4002
PSPN -3935
PSMC1 -3916
RAC1 -3826
ST8SIA2 -3757
FYN -3672
UNC5C -3670
PIK3R3 -3558
PSMD9 -3447
SCN3B -3441
EPHA5 -3386
COL4A1 -3098
PSMB5 -3070
ARHGEF7 -3008
TRPC3 -2744
ANK1 -2389
MYH14 -2093
SCN8A -2008
RET -1877
NCAN -1857
EPHA6 -1656
ABLIM2 -1605
SPTBN4 -1595
EPHA10 -1580
RGMA -1224
PIP5K1C -1077
KIF4A -934
EPHA8 -914
PFN1 -894
DPYSL4 -573
CACNA1I -496
FARP2 -489
LHX2 -322
SEMA4D 34
FES 56
CACNB3 139
SCN4B 314
EFNA3 376
PAK6 418
DOK4 640
PSMC6 758
LDB1 816
RAP1GAP 858
PSMA5 902
DPYSL5 1030
GRB7 1054
MBP 1078
PSMD10 1419
SCN2B 1700
RPL10 1774
ITGA10 1862
COL4A3 1889
LIMK2 1953
ROBO2 1963
SCN3A 2054
GRIN1 2153
EFNA4 2221
TRPC4 2224
PLXNA3 2233
DAB1 2297
ADGRV1 2538
CACNB4 2543
CACNA1G 2794
SCN2A 2918
VAV3 3273
AKAP5 3369
GFRA1 3471
COL6A6 3741
CD72 3809
ARPC1A 3918
MYH11 4038
EPHB3 4425
ISL1 4433
RPS6KA6 4635
EPHA1 4934
MAPK11 4949
SCN7A 5518
COL9A1 5534
EPHA7 5626
CNTN2 5742
DOK5 5824
RPL21 6069
SCN1A 6115
RPS3A 6205
RPS6KA4 6325
SEMA4A 6386
SPTBN5 6771
ARTN 6833
LYPLA2 6897
NFASC 7108
AP2S1 7144
MYL6 7420
SCN9A 7434
POU3F1 7483
RHOB 7663
RPS27A 7697
EFNA2 7707
MAP2K2 7936
RPL13A 8281
UBC 8359
SCN11A 8382
ARPC4 8811
RPL3L 9364
SPTB 9370
CACNA1D 9379
CRMP1 9686
EPHB6 9725
LIMK1 9759
COL4A5 9860
PSMD14 9962
NAB2 10046
RND1 10270
PSMD12 10294
DRP2 10390
NCAM1 10391
RPS2 10438
PSMB2 10501
PSMA6 10525
RPS29 10608
ITGA2B 10702
RBM8A 10786
RPL22 11069
PRKACA 11230
CACNB2 11488
NRTN 11673
RPS9 11743
MSI1 11816
RPL8 11881
MAPK13 11974
MAPK12 12003
EVL 12005
PSMA1 12138
RPS10 12226
PSMB9 12294
CFL1 12378
PLCG1 12415
PSMB6 12465
PSMC2 12636
RPL30 12665
ACTB 12676
PSMB8 12723
MYL9 12758
RRAS 12763
CLTB 12833
RPS27 12843
COL9A3 12892
PSEN2 12993
PSMA4 13022
RPSA 13154
RPS12 13178
RPL27 13203
RPS17 13209
UBA52 13217
PSMB10 13241
RPL7A 13286
UPF3A 13296
PSMD4 13334
PSME1 13459
CDK5 13460
RPS23 13488
RPL18A 13507
PDLIM7 13515
RPL39 13544
CSNK2B 13594
UBB 13607
PSMC5 13624
PLXNB1 13632
RPL5 13658
KCNQ2 13679
RPS3 13719
PSMD13 13724
ROBO3 13734
RPL15 13737
MAGOHB 13785
RPL22L1 13806
PSMD6 13813
CACNB1 13817
RPS4X 13824
HOXA2 13898
HRAS 13906
PSMC3 13913
RPL11 13968
RPS6 13991
RPS14 14014
MYL12B 14029
PSMB7 14048
PSMB1 14066
RPS28 14071
ARPC3 14139
RPL4 14145
PSMA3 14148
RPL13 14186
RPS13 14240
RPL26 14246
RPL37A 14263
UPF3B 14273
RPS25 14278
RPL36AL 14290
PSMC4 14302
RPL6 14318
RPLP1 14319
RPS8 14333
RPS27L 14338
ELOC 14352
RPL26L1 14358
RPL35A 14377
PSENEN 14386
RPL18 14388
RPL9 14394
CACNA1S 14436
RPL36 14456
PSME2 14457
RPS19 14476
RPS15 14496
RPL17 14497
RPL19 14499
RPL29 14503
RBX1 14507
RPL23 14510
RPS11 14523
RPS16 14529
MAGOH 14535
RPL28 14550
COL9A2 14557
RPS7 14564
RPL32 14571
RPS18 14572
RPS15A 14577
RPL12 14580
RPL24 14583
RPL34 14584
PSMB4 14586
RPLP2 14587
RPL36A 14597
ELOB 14608
RPS21 14610
RPS24 14622
RPL27A 14639
PSMB3 14666
RPS20 14683
RPL35 14685
FAU 14690
SEM1 14696
RPS26 14702
RPL31 14719
DNM1 14721
RPL37 14722
RPL14 14725
RPL38 14728


PTEN Regulation

PTEN Regulation
16
set PTEN Regulation
setSize 140
pANOVA 0.0169
s.dist -0.117
p.adjustANOVA 0.0271



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNKS2 -11181
MAPK1 -11008
AGO2 -11001
GATAD2B -10957
PSME4 -10945
AKT3 -10936
REST -10773
RCOR1 -10716
CSNK2A1 -10688
PSMD1 -10543
PSMD2 -10480
CSNK2A2 -10434
CHD4 -10293
TNKS -10209
MKRN1 -10078
PHC3 -10026
RRAGC -9892
RNF2 -9832
BMI1 -9665
USP7 -9624

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNKS2 -11181
MAPK1 -11008
AGO2 -11001
GATAD2B -10957
PSME4 -10945
AKT3 -10936
REST -10773
RCOR1 -10716
CSNK2A1 -10688
PSMD1 -10543
PSMD2 -10480
CSNK2A2 -10434
CHD4 -10293
TNKS -10209
MKRN1 -10078
PHC3 -10026
RRAGC -9892
RNF2 -9832
BMI1 -9665
USP7 -9624
PHC2 -9553
CNOT6L -9463
KDM1A -9433
ATF2 -9391
MAPK3 -9373
RRAGD -9212
TRIM27 -9156
HDAC5 -9155
NEDD4 -9106
XIAP -8914
TNRC6B -8847
VAPA -8686
USP13 -8646
PTEN -8635
PSMD11 -8620
HDAC7 -8553
AGO3 -8484
CHD3 -8425
PSMD5 -8141
GATAD2A -8014
PSME3 -7915
AGO4 -7827
LAMTOR1 -7824
RRAGA -7783
PSMA7 -7709
HDAC3 -7578
SLC38A9 -7228
MECOM -7082
PML -7081
OTUD3 -7055
SNAI2 -6913
AGO1 -6821
HDAC2 -6806
PSMD8 -6628
RBBP7 -6358
ATN1 -6254
PSMD7 -6145
MTOR -6010
CBX6 -5924
TNRC6C -5761
WWP2 -5628
TNRC6A -5504
CBX4 -5298
CBX2 -5230
SNAI1 -5078
MLST8 -4999
RPTOR -4928
PSMD3 -4900
PREX2 -4688
RBBP4 -4584
PSMA2 -4532
PSMF1 -4471
MAF1 -4062
PSMC1 -3916
PSMD9 -3447
PSMB5 -3070
FRK -2930
EED -1655
AKT1 -1284
NR2E1 -967
PTENP1 -567
PSMC6 758
PSMA5 902
STUB1 1158
PSMD10 1419
RNF146 2088
AKT2 3933
RHEB 5078
EGR1 5135
RRAGB 5473
PHC1 5685
MTA2 6546
SCMH1 7371
LAMTOR3 7401
JUN 7504
RPS27A 7697
UBC 8359
PSMD14 9962
PSMD12 10294
PSMB2 10501
PSMA6 10525
PPARG 10907
SUZ12 11477
TP53 11698
LAMTOR2 11734
MTA3 11965
CBX8 12046
MOV10 12123
PSMA1 12138
PSMB9 12294
LAMTOR4 12402
MTA1 12405
PSMB6 12465
PSMC2 12636
LAMTOR5 12649
PSMB8 12723
PSMA4 13022
HDAC1 13024
RING1 13065
UBA52 13217
PSMB10 13241
PSMD4 13334
PSME1 13459
CSNK2B 13594
UBB 13607
PSMC5 13624
PSMD13 13724
PSMD6 13813
MBD3 13875
PSMC3 13913
PSMB7 14048
PSMB1 14066
PSMA3 14148
SALL4 14194
EZH2 14297
PSMC4 14302
PSME2 14457
PSMB4 14586
PSMB3 14666
SEM1 14696


Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)
23
set Signaling by the B Cell Receptor (BCR)
setSize 106
pANOVA 0.0432
s.dist -0.114
p.adjustANOVA 0.061



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR1 -11377
FBXW11 -11175
ITPR3 -10980
PSME4 -10945
AHCYL1 -10915
NFKB1 -10909
PPP3CA -10754
ORAI2 -10661
GRB2 -10626
RELA -10559
PSMD1 -10543
ITPR2 -10484
PSMD2 -10480
REL -10302
PPP3R1 -10098
NCK1 -10095
SOS1 -10023
NRAS -9826
SKP1 -9675
PIK3R1 -9670

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR1 -11377
FBXW11 -11175
ITPR3 -10980
PSME4 -10945
AHCYL1 -10915
NFKB1 -10909
PPP3CA -10754
ORAI2 -10661
GRB2 -10626
RELA -10559
PSMD1 -10543
ITPR2 -10484
PSMD2 -10480
REL -10302
PPP3R1 -10098
NCK1 -10095
SOS1 -10023
NRAS -9826
SKP1 -9675
PIK3R1 -9670
PIK3CD -9626
ORAI1 -9582
NFATC3 -9413
NFATC1 -9330
KRAS -8721
PSMD11 -8620
BTRC -8533
SH3KBP1 -8328
PSMD5 -8141
PSME3 -7915
PSMA7 -7709
MAP3K7 -7399
PPP3CB -7240
STIM1 -7092
CALM1 -7050
BCL10 -6950
TRPC1 -6909
PSMD8 -6628
NFATC2 -6401
NFKBIE -6347
PRKCB -6325
CHUK -6296
PSMD7 -6145
LYN -6130
MALT1 -5582
PIK3AP1 -5530
CUL1 -5083
PSMD3 -4900
PSMA2 -4532
RASGRP1 -4518
PSMF1 -4471
PSMC1 -3916
FYN -3672
SYK -3588
BLNK -3503
PSMD9 -3447
PLCG2 -3353
BLK -3197
PSMB5 -3070
PSMC6 758
NFKBIA 806
PSMA5 902
PSMD10 1419
CD79A 1777
CD79B 1897
CARD11 1948
BTK 2382
CD22 6062
RASGRP3 6141
PTPN6 6610
VAV1 7109
RPS27A 7697
UBC 8359
IKBKB 9592
PSMD14 9962
IKBKG 10136
PSMD12 10294
PSMB2 10501
PSMA6 10525
FKBP1A 10941
NFKBIB 11054
PSMA1 12138
PSMB9 12294
PSMB6 12465
PSMC2 12636
PSMB8 12723
PSMA4 13022
UBA52 13217
PSMB10 13241
PSMD4 13334
PSME1 13459
UBB 13607
PSMC5 13624
PSMD13 13724
PSMD6 13813
HRAS 13906
PSMC3 13913
PSMB7 14048
PSMB1 14066
PSMA3 14148
PSMC4 14302
PSME2 14457
PSMB4 14586
PSMB3 14666
SEM1 14696
PPIA 14701


Mitochondrial biogenesis

Mitochondrial biogenesis
7
set Mitochondrial biogenesis
setSize 91
pANOVA 0.121
s.dist -0.0939
p.adjustANOVA 0.146



Top enriched genes

Top 20 genes
GeneID Gene Rank
HELZ2 -11323
PPARA -11203
MED1 -11056
PRKAB2 -11027
NCOA2 -11006
ALAS1 -10837
MEF2D -10645
CREBBP -10636
APOOL -10620
GLUD1 -10420
IMMT -9888
CHD9 -9830
TBL1XR1 -9743
ATP5F1A -9726
HCFC1 -9618
NCOA6 -9403
ATF2 -9391
TFB2M -9130
ATP5F1B -9117
CREB1 -8757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HELZ2 -11323
PPARA -11203
MED1 -11056
PRKAB2 -11027
NCOA2 -11006
ALAS1 -10837
MEF2D -10645
CREBBP -10636
APOOL -10620
GLUD1 -10420
IMMT -9888
CHD9 -9830
TBL1XR1 -9743
ATP5F1A -9726
HCFC1 -9618
NCOA6 -9403
ATF2 -9391
TFB2M -9130
ATP5F1B -9117
CREB1 -8757
PRKAA2 -8711
NCOA1 -8498
GABPA -8422
SOD2 -8364
TBL1X -8349
MAPK14 -7640
HDAC3 -7578
TGS1 -7548
CRTC3 -7493
PRKAG1 -7356
CHCHD3 -7319
IDH2 -7278
CARM1 -7172
CALM1 -7050
CAMK4 -6805
TFAM -6677
PPARGC1B -6567
NCOR1 -6424
PRKAB1 -6343
RXRA -6110
SAMM50 -6035
ATP5PB -5905
NRF1 -5813
PRKAG2 -5726
PPARGC1A -5601
PPRC1 -4924
GLUD2 -4612
GABPB1 -4574
MEF2C -4363
POLRMT -3050
CRTC1 -2998
CHCHD6 563
CRTC2 2189
DMAC2L 2983
MAPK11 4949
NR1D1 5538
TFB1M 5669
POLG2 5859
HSPA9 7805
SIRT5 7975
MTERF1 8134
ACSS2 8505
TMEM11 9339
SIRT4 10935
SIRT3 11635
PERM1 11911
MAPK12 12003
ESRRA 12285
MTX2 12381
CYCS 12448
ATP5F1E 12512
DNAJC11 12587
ATP5MC3 12746
SMARCD3 12997
APOO 13431
MTX1 13572
ATP5MC2 13992
ATP5F1C 14105
MICOS10 14147
MT-ATP8 14192
SSBP1 14231
MICOS13 14258
ATP5PF 14301
ATP5PO 14446
ATP5F1D 14567
ATP5MC1 14573
MT-ATP6 14606
ATP5MG 14649
ATP5MF 14664
ATP5ME 14724
ATP5PD 14740


Gene Silencing by RNA

Gene Silencing by RNA
4
set Gene Silencing by RNA
setSize 97
pANOVA 0.206
s.dist -0.0743
p.adjustANOVA 0.235



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGO2 -11001
POLR2A -10839
NUP155 -10822
NUP153 -10535
RANBP2 -10436
NUP58 -10410
NUP98 -10237
DICER1 -10191
NUP160 -9956
POM121 -9851
IPO8 -9838
POLR2B -9677
NDC1 -9301
POM121C -9191
TDRKH -9176
TNRC6B -8847
SEC13 -8748
NUP133 -8692
AGO3 -8484
NUP54 -8450

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGO2 -11001.0
POLR2A -10839.0
NUP155 -10822.0
NUP153 -10535.0
RANBP2 -10436.0
NUP58 -10410.0
NUP98 -10237.0
DICER1 -10191.0
NUP160 -9956.0
POM121 -9851.0
IPO8 -9838.0
POLR2B -9677.0
NDC1 -9301.0
POM121C -9191.0
TDRKH -9176.0
TNRC6B -8847.0
SEC13 -8748.0
NUP133 -8692.0
AGO3 -8484.0
NUP54 -8450.0
XPO5 -8004.0
NUP205 -7950.0
AGO4 -7827.0
HSP90AA1 -7636.0
PRKRA -6976.0
AGO1 -6821.0
PIWIL4 -6653.0
NUP214 -6405.0
NUP93 -6357.0
NUP62 -6136.0
TPR -5936.0
TNRC6C -5761.0
SEH1L -5755.0
H2AC6 -5672.0
TNRC6A -5504.0
NUP210 -5362.0
H2BC12 -5229.0
NUP188 -5131.0
RAE1 -5118.0
POLR2C -5040.0
TSN -4856.0
TSNAX -4586.0
NUP50 -4049.0
POLR2E -3791.0
PLD6 -2947.0
H2BC15 -2733.0
ELAC2 -1278.0
DROSHA -892.0
BCDIN3D -646.0
MAEL -644.0
DDX4 1878.0
H2AC18 1911.0
TDRD12 2291.0
NUP88 2407.0
ASZ1 2949.0
H3C1 3171.0
TDRD6 3217.0
H2AB1 3456.0
H2AC7 4317.0
FKBP6 4673.0
H2BC4 4759.0
H2BC13 4801.0
H2BC11 4918.0
POLR2D 5295.0
PIWIL2 5621.0
H2BC21 6192.0
RAN 6568.0
MYBL1 6983.0
H2AC14 7113.0
H2BC17 7486.0
ANG 7607.0
H2BU1 7988.0
H3C15 9115.5
H2BC9 9248.0
NUP35 9591.0
NUP42 10670.0
HENMT1 10751.0
NUP43 11189.0
POLR2G 11318.0
H2AZ2 11408.0
NUP37 11671.0
TARBP2 11788.0
NUP85 12061.0
H2AZ1 12183.0
NUP107 12782.0
H2BC5 12839.0
POLR2L 13110.0
DGCR8 13556.0
POLR2K 13902.0
H3-3A 13915.0
AAAS 13971.0
H2AC20 14061.0
POLR2F 14209.0
POLR2I 14247.0
POLR2H 14255.0
H2AJ 14469.0
POLR2J 14516.0


Mitophagy

Mitophagy
11
set Mitophagy
setSize 28
pANOVA 0.608
s.dist -0.0559
p.adjustANOVA 0.664



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2A1 -10688
CSNK2A2 -10434
TOMM20 -10241
TOMM70 -9823
MFN1 -9236
PINK1 -8616
MFN2 -8316
ULK1 -7444
SRC -7386
ATG5 -7330
SQSTM1 -7003
ATG12 -5792
TOMM7 -5586
PGAM5 -4577
MAP1LC3B -1844
VDAC1 -438
RPS27A 7697
UBC 8359
TOMM22 9343
MAP1LC3A 10182

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2A1 -10688
CSNK2A2 -10434
TOMM20 -10241
TOMM70 -9823
MFN1 -9236
PINK1 -8616
MFN2 -8316
ULK1 -7444
SRC -7386
ATG5 -7330
SQSTM1 -7003
ATG12 -5792
TOMM7 -5586
PGAM5 -4577
MAP1LC3B -1844
VDAC1 -438
RPS27A 7697
UBC 8359
TOMM22 9343
MAP1LC3A 10182
FUNDC1 10637
UBA52 13217
TOMM6 13247
MTERF3 13494
CSNK2B 13594
UBB 13607
TOMM40 13789
TOMM5 14468


Diseases of carbohydrate metabolism

Diseases of carbohydrate metabolism
3
set Diseases of carbohydrate metabolism
setSize 30
pANOVA 0.713
s.dist -0.0388
p.adjustANOVA 0.713



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNS -11227
GBE1 -11096
IDS -10234
GLB1 -9342
GYG1 -8931
GYS1 -8475
ARSB -7596
GALNS -6472
GAA -6463
PPP1R3C -5737
NAGLU -5401
RPIA -4236
HGSNAT -4061
GYG2 -1578
ALDOB -1505
KHK -1233
HYAL1 607
EPM2A 2867
RPS27A 7697
NHLRC1 7736

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNS -11227
GBE1 -11096
IDS -10234
GLB1 -9342
GYG1 -8931
GYS1 -8475
ARSB -7596
GALNS -6472
GAA -6463
PPP1R3C -5737
NAGLU -5401
RPIA -4236
HGSNAT -4061
GYG2 -1578
ALDOB -1505
KHK -1233
HYAL1 607
EPM2A 2867
RPS27A 7697
NHLRC1 7736
UBC 8359
SGSH 9716
GUSB 10432
SLC37A4 11019
TALDO1 13122
IDUA 13198
UBA52 13217
G6PC3 13527
UBB 13607
DCXR 13987


Metabolism

Metabolism
5
set Metabolism
setSize 1881
pANOVA 0.00846
s.dist -0.0364
p.adjustANOVA 0.0169



Top enriched genes

Top 20 genes
GeneID Gene Rank
LRP10 -11389
CEMIP -11386
SLC2A3 -11385
PFKFB3 -11378
ITPR1 -11377
CSPG4 -11375
VCAN -11365
SEC24A -11350
SEC23A -11349
PGM1 -11340
SEC24D -11338
GPC6 -11331
IQGAP1 -11328
HELZ2 -11323
ESYT2 -11309
AGRN -11307
ARNT2 -11293
PSAP -11287
LYPLA1 -11278
CHST15 -11271

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LRP10 -11389
CEMIP -11386
SLC2A3 -11385
PFKFB3 -11378
ITPR1 -11377
CSPG4 -11375
VCAN -11365
SEC24A -11350
SEC23A -11349
PGM1 -11340
SEC24D -11338
GPC6 -11331
IQGAP1 -11328
HELZ2 -11323
ESYT2 -11309
AGRN -11307
ARNT2 -11293
PSAP -11287
LYPLA1 -11278
CHST15 -11271
CAV1 -11260
PGK1 -11258
PLIN3 -11255
SEC24C -11244
MTMR12 -11240
NT5E -11236
LRP12 -11231
GNS -11227
PPP2R5D -11215
HK2 -11205
PPARA -11203
LPIN2 -11189
OSBP -11168
ST3GAL1 -11163
SBF2 -11155
PTGS2 -11142
NCOA3 -11136
ARG2 -11135
MED13 -11134
SMOX -11123
PYCR1 -11114
ADCY1 -11110
GBE1 -11096
PARP4 -11094
CHSY1 -11090
ACER3 -11070
MED1 -11056
CPNE3 -11054
NMNAT2 -11051
PRKAR2A -11045
ESYT1 -11040
SERINC1 -11029
PRKAB2 -11027
OSBPL10 -11025
LDLR -11022
PITPNM1 -11013
NCOA2 -11006
CERS6 -11002
EPRS1 -10997
DSE -10995
MED13L -10984
ITPR3 -10980
CERS2 -10956
SPTLC2 -10955
PSME4 -10945
ADCY6 -10943
DLST -10933
PRKD3 -10922
HACD3 -10916
AHCYL1 -10915
CAD -10912
NNT -10892
PAPSS2 -10873
CERT1 -10863
NAMPT -10853
GNB1 -10852
ALAS1 -10837
B4GALT1 -10827
LRP1 -10823
NUP155 -10822
PGAM1 -10821
SERINC3 -10820
HS2ST1 -10810
XYLT1 -10807
NDST1 -10800
GNG12 -10798
EP300 -10774
TPST2 -10765
SREBF2 -10761
SDC4 -10735
PRKAR1A -10732
KDSR -10730
ABCA1 -10729
MGLL -10706
CSNK2A1 -10688
HMGCR -10672
HK1 -10668
CSGALNACT2 -10666
AZIN1 -10652
CS -10647
CREBBP -10636
HS3ST3B1 -10632
STXBP1 -10605
ALDH18A1 -10575
ACSL3 -10572
SLC26A2 -10551
PSMD1 -10543
NUP153 -10535
PLEKHA2 -10533
PYGL -10527
ADCY7 -10524
PANK3 -10501
PRKCA -10498
ITPR2 -10484
PSMD2 -10480
RAB14 -10469
GPHN -10463
RGL1 -10462
SEC24B -10451
PRKD2 -10437
RANBP2 -10436
CSNK2A2 -10434
GLUD1 -10420
TNFRSF21 -10417
NUP58 -10410
PIKFYVE -10408
INSIG1 -10393
PI4KB -10391
NUDT3 -10390
CA2 -10386
PIK3CB -10352
ACSL4 -10350
OSBPL8 -10344
SIN3A -10335
MIGA1 -10329
CHST11 -10289
MTMR3 -10288
PNP -10278
PLEKHA1 -10277
SLC2A1 -10266
ALDOC -10263
NUP98 -10237
PPIP5K2 -10236
CHST3 -10235
IDS -10234
UGP2 -10233
SERINC5 -10225
MTF1 -10221
PFKP -10212
CRYL1 -10200
MBTPS2 -10192
PLPP3 -10189
ME2 -10188
NDUFS2 -10170
ARNT -10165
BCKDHA -10142
ACLY -10141
ABCB7 -10138
PPP2CB -10130
MED14 -10125
ADIPOR2 -10094
MAN2B1 -10090
SDHA -10088
BPNT2 -10082
NFYA -10065
SP1 -10062
UGDH -10059
TXNRD1 -10057
PYGB -10049
PPAT -10038
GLUL -10037
SELENOI -10031
SGMS1 -10020
AMD1 -10017
PGM2L1 -9987
LCLAT1 -9976
CRAT -9970
SLC16A1 -9961
CES2 -9957
NUP160 -9956
CLOCK -9948
GPD2 -9923
PTGES3 -9912
SQLE -9895
SLC35B2 -9894
B4GALT5 -9878
CD44 -9874
PPP1CC -9873
CHSY3 -9871
HSPG2 -9870
PLD1 -9865
POM121 -9851
IMPDH2 -9850
GNB4 -9847
SGPL1 -9845
MTR -9844
CHD9 -9830
MMUT -9758
CDS2 -9752
NDST2 -9746
TBL1XR1 -9743
ITPKB -9731
SRD5A3 -9729
ATP5F1A -9726
NCOR2 -9717
PRKACB -9716
ELOVL5 -9707
FADS1 -9703
PIK3CA -9701
DDHD1 -9692
IARS1 -9672
PIK3R1 -9670
B4GALT6 -9663
AHR -9661
SC5D -9656
SPHK1 -9653
GART -9647
HMGCS1 -9637
PIK3CD -9626
PIK3C2A -9621
CPT2 -9610
SLC25A32 -9607
PIP4K2C -9600
AMPD3 -9586
PLEKHA8 -9583
CHST6 -9576
B4GALT3 -9571
CHST1 -9558
OSBPL3 -9547
FASN -9525
PIK3R4 -9524
SARS1 -9523
PDP1 -9519
L2HGDH -9505
BCAT1 -9473
NAT8L -9452
SUMF2 -9440
MTMR2 -9438
KPNB1 -9428
COX15 -9412
ENO1 -9408
NCOA6 -9403
SAMD8 -9386
AK4 -9380
ACBD5 -9376
SGPP1 -9362
PLA2G4A -9352
B3GALT5 -9346
GLB1 -9342
ADCY9 -9337
ACACA -9333
PDK1 -9327
EXT2 -9326
GNA11 -9324
LPGAT1 -9323
PGM2 -9321
PPP1CB -9314
LDHA -9307
LRP8 -9305
NDC1 -9301
FUT4 -9296
GNAI1 -9293
OSBPL1A -9292
PPM1L -9282
PIP5K1A -9280
MOCOS -9275
ADO -9258
KYAT3 -9254
AGPAT3 -9226
HSP90AB1 -9216
CDK8 -9200
POM121C -9191
LRPPRC -9188
CYP51A1 -9173
HAS2 -9167
CPOX -9163
SLC6A8 -9160
DCTD -9148
DDHD2 -9129
STARD7 -9124
ATP5F1B -9117
ACSL1 -9103
RIMKLA -9096
NAGS -9087
EHHADH -9084
RORA -9082
PFKL -9074
GPC4 -9044
AMPD2 -9033
MTMR6 -9027
SUCLG2 -9019
INPP4A -8999
SLC19A2 -8984
MTMR4 -8979
AGPAT5 -8978
HSD17B12 -8967
LBR -8965
ADA -8960
CA12 -8949
GNAQ -8942
VKORC1L1 -8940
GYG1 -8931
FITM2 -8928
SGMS2 -8919
GLS -8911
CEPT1 -8905
PDK3 -8900
B3GNT2 -8899
RPL7 -8891
MARCKS -8886
MDH2 -8870
RRM2B -8861
FUT11 -8854
SLC35D1 -8849
PLCH2 -8845
ODC1 -8817
PRKD1 -8809
NEU3 -8799
SLC36A4 -8770
UQCRFS1 -8759
GPAT3 -8758
PARP8 -8753
DBT -8750
SEC13 -8748
LPL -8740
ENTPD7 -8733
UST -8717
PNPLA8 -8716
PRKAA2 -8711
HACD2 -8704
ARSJ -8695
ETNK2 -8693
NUP133 -8692
WASL -8689
PKM -8687
VAPA -8686
AGPAT1 -8683
ADRA2A -8679
HADHB -8672
HAS3 -8670
MAT2B -8665
SCD5 -8663
SORD -8655
IPMK -8649
PTDSS1 -8645
PDP2 -8640
PTEN -8635
PSMD11 -8620
CERK -8619
OCRL -8617
MTRR -8615
VAPB -8601
INSIG2 -8589
RAB5A -8585
SCD -8571
GCLM -8557
GNPDA1 -8527
PNPLA3 -8509
MMADHC -8504
NCOA1 -8498
INPP5F -8487
IMPA2 -8486
GYS1 -8475
DHTKD1 -8474
STARD4 -8472
SPTLC1 -8463
HS3ST3A1 -8460
ABCB4 -8458
TPST1 -8451
NUP54 -8450
CMPK1 -8439
ALDH6A1 -8433
NADK2 -8428
MTHFD1L -8424
PITPNB -8406
DLD -8396
PCTP -8395
CYP11A1 -8389
ABCC1 -8382
PHKA1 -8360
AGPS -8357
TBL1X -8349
COX7A2L -8331
RPL10A -8314
ST3GAL2 -8313
SLC44A1 -8297
BTD -8287
MED23 -8281
GPAM -8280
INPP5A -8253
B4GALT4 -8231
MBOAT2 -8226
MTMR9 -8214
PDPR -8205
PIP4K2A -8192
GCLC -8164
PSMD5 -8141
RETSAT -8135
HADHA -8132
NUBPL -8112
PLEKHA5 -8093
MSMO1 -8087
ACOX1 -8084
GALC -8072
RPS5 -8067
PLD2 -8038
TPI1 -8037
GPC1 -8024
PFKM -8020
ETFA -8019
CNDP2 -8018
MAPKAPK2 -8013
MINPP1 -7992
CHST2 -7988
FHL2 -7979
PIK3C3 -7967
CHP1 -7963
PRPS1 -7954
HLCS -7952
NUP205 -7950
DCK -7947
ABHD4 -7944
PTPN13 -7935
LMBRD1 -7931
OGDH -7930
PSME3 -7915
MTM1 -7910
PAICS -7887
VAC14 -7876
ENO2 -7871
PC -7860
ACADM -7858
DLAT -7847
NUDT4 -7818
PANK1 -7813
PTGR1 -7806
MBOAT7 -7802
PPM1K -7791
LSS -7789
SACM1L -7768
SUCLA2 -7753
TMLHE -7751
MED12 -7721
STARD3NL -7713
PSMA7 -7709
DDAH1 -7702
MID1IP1 -7683
RXRB -7652
HSP90AA1 -7636
RRM1 -7633
GLCE -7616
ADCY3 -7605
CDK19 -7601
ARSB -7596
GMPS -7594
ME1 -7590
HDAC3 -7578
PI4K2B -7570
PCCA -7560
TGS1 -7548
CCNC -7538
GLDC -7522
SBF1 -7507
PLA2G12A -7505
CA9 -7491
FAM120B -7478
AASS -7440
RPLP0 -7433
XYLT2 -7418
SHPK -7394
OSBPL9 -7367
SLC44A5 -7363
CPT1A -7359
RARS1 -7354
RAPGEF3 -7328
PPP2CA -7327
GNB2 -7326
FECH -7307
CARNMT1 -7305
MTHFD2 -7296
ELOVL1 -7292
MMS19 -7289
IDH2 -7278
UGCG -7275
ACAA2 -7254
ARSK -7251
LGMN -7234
LTA4H -7230
B3GALNT1 -7212
SDC1 -7206
GATM -7197
ITPKC -7191
GPI -7190
CARM1 -7172
NDUFS1 -7143
ACOX3 -7136
FUT10 -7133
ADIPOR1 -7115
MTMR1 -7109
B4GALNT2 -7088
CHRM3 -7068
CALM1 -7050
SLC25A44 -7044
AKR7A2 -7035
HACL1 -7031
BCKDK -7009
LPCAT2 -7006
COX10 -6996
CDIPT -6957
SMPD1 -6948
HS6ST2 -6933
NUDT11 -6930
TNFAIP8L1 -6914
PARP14 -6910
ELOVL7 -6897
SCAP -6895
MCCC1 -6892
BPNT1 -6880
ECI2 -6873
GCH1 -6867
SDC3 -6862
PI4K2A -6857
IP6K1 -6844
PIP5K1B -6840
RFK -6817
QARS1 -6790
B3GNT7 -6770
OXCT1 -6764
ABHD5 -6759
THTPA -6758
AGL -6756
ARF3 -6750
GPAT4 -6685
SLC27A1 -6681
CIAPIN1 -6644
SCO1 -6639
PSMD8 -6628
IMPA1 -6627
SECISBP2 -6619
CTPS2 -6591
DCTPP1 -6587
FADS2 -6580
PPARGC1B -6567
FDFT1 -6563
SLC16A3 -6554
SLC44A2 -6531
MED8 -6530
UBIAD1 -6528
UGT8 -6526
XDH -6520
MBTPS1 -6515
MTHFR -6498
MTMR10 -6497
ARSD -6486
RAP1A -6474
GAA -6463
HILPDA -6453
ELOVL4 -6438
INPP5D -6437
NCOR1 -6424
PLEKHA3 -6412
NUP214 -6405
ADCY5 -6394
EXT1 -6377
IDI1 -6373
RPL39L -6371
SLC35D2 -6370
KCNS3 -6363
ALDH9A1 -6360
NUP93 -6357
PIK3C2B -6354
MED17 -6334
SLC25A15 -6321
PLPP6 -6298
PDSS2 -6292
AACS -6291
PLA2R1 -6284
MED20 -6259
SLC35B3 -6255
INPP5B -6243
ETHE1 -6241
QDPR -6222
RPL41 -6176
OSBPL2 -6175
SYNJ1 -6174
NMNAT1 -6170
CHPF -6168
ANGPTL4 -6167
PSMD7 -6145
NUP62 -6136
UQCRC2 -6128
HS6ST1 -6124
RXRA -6110
SRD5A1 -6095
MAT2A -6089
MAOA -6062
PLCD1 -6060
PLA2G4C -6036
ALDH3A2 -6032
UCK2 -6022
PI4KA -5998
LPCAT1 -5970
MVD -5963
LARS1 -5961
CTSA -5957
PIK3R2 -5950
SLC23A2 -5948
AANAT -5938
TPR -5936
MAN2B2 -5935
GDPD1 -5923
MED21 -5912
HSD3B7 -5909
ATP5PB -5905
PCCB -5898
DPYD -5893
PUDP -5874
OSBPL5 -5861
DHFR2 -5841
SDC2 -5839
GNB5 -5838
PCYT1A -5835
PGS1 -5826
LPIN1 -5823
FAR2 -5822
AMACR -5821
NRF1 -5813
PLCD3 -5800
TIAM2 -5789
CYP27B1 -5786
CYP24A1 -5758
SEH1L -5755
CYP2U1 -5750
SCP2 -5746
CYP1B1 -5742
PPP1R3C -5737
PLIN2 -5733
PRKAG2 -5726
DNM2 -5707
RPE -5704
GDE1 -5702
ARF1 -5663
SDHC -5661
TRIB3 -5654
FIG4 -5627
SLC25A20 -5625
PPARGC1A -5601
IMPDH1 -5600
SYNJ2 -5589
PPP2R1B -5567
ACAN -5556
MED16 -5554
CHST7 -5550
PRPS2 -5526
PDXK -5519
GNG2 -5496
B3GALT4 -5456
TNFAIP8 -5455
ENTPD3 -5442
OCA2 -5431
NAGLU -5401
SLC9A1 -5378
UPP1 -5377
NUP210 -5362
RPL23A -5359
SLC52A2 -5340
SLC37A1 -5328
ALDH1B1 -5319
HMGCL -5306
GCHFR -5295
THRAP3 -5293
ACP6 -5288
HTD2 -5287
PRKAR2B -5268
PAOX -5267
ADK -5228
PIK3CG -5212
DHCR24 -5203
B3GALT1 -5202
SEPSECS -5198
ACOT7 -5191
PLA2G15 -5190
ACSS1 -5188
NDUFB5 -5177
PARP16 -5144
CHPT1 -5137
NUP188 -5131
RAE1 -5118
HSD17B2 -5115
NUDT10 -5100
GSR -5098
GNPDA2 -5096
B4GALT7 -5082
ISCA1 -5073
INMT -5054
PRKAR1B -5036
PDHX -5030
AHRR -5028
ASAH2 -5024
PLAAT1 -5010
AASDHPPT -5003
HPSE -5000
PNPLA6 -4995
ST6GALNAC6 -4992
TPK1 -4987
ACER2 -4969
SLC7A5 -4941
PPP2R1A -4930
GALK1 -4926
NFS1 -4918
ABHD10 -4916
MED26 -4913
CA14 -4906
PSMD3 -4900
HSD3B1 -4883
HSD11B1 -4872
SUMF1 -4871
ETNK1 -4852
DHCR7 -4842
OAZ2 -4838
SAMHD1 -4830
ABCB1 -4813
ARSI -4803
ALDH1L1 -4789
PITPNM2 -4781
ESD -4712
AK5 -4704
CYP2S1 -4701
RHCE -4697
ALDOA -4676
ELOVL6 -4659
FUT1 -4657
IDH3B -4653
GAPDH -4645
RPL3 -4637
CYB5R3 -4622
GLUD2 -4612
NUDT19 -4598
SLC51B -4549
PSMA2 -4532
IVD -4522
HSD3B2 -4507
IL4I1 -4498
GM2A -4493
PLCH1 -4489
CACNA1C -4487
PSMF1 -4471
FABP3 -4463
B4GALT2 -4462
MBOAT1 -4456
SLC46A1 -4448
INPPL1 -4429
FPGS -4426
SERINC2 -4401
ENTPD1 -4399
NDUFA10 -4387
PARP9 -4368
NUDT16 -4364
COASY -4361
MED22 -4354
GDPD5 -4344
ACAT1 -4340
ARSG -4310
RAB4A -4268
ACSF3 -4245
RPIA -4236
AOC2 -4222
SLC25A13 -4204
ST3GAL3 -4202
FAR1 -4160
MED24 -4137
VKORC1 -4122
BCAN -4115
COX11 -4100
SYT5 -4090
SPHK2 -4065
NUP50 -4049
PLCE1 -4045
HS3ST5 -4036
GMPR2 -4035
PAPSS1 -4029
ALOX12 -4017
PIAS4 -3962
PRSS3 -3953
PSMC1 -3916
PDK4 -3900
ALDH4A1 -3892
NT5C3A -3862
KCNJ11 -3858
PPT1 -3843
CTH -3820
PPA1 -3780
ACSS3 -3765
B3GNT3 -3761
GNAI2 -3728
PLD3 -3725
OAT -3707
SUMO2 -3697
G6PD -3643
NEU2 -3630
MED29 -3629
SLC6A11 -3627
OLAH -3621
CBR4 -3601
EEFSEC -3593
ABCG2 -3574
PHKB -3565
PIK3R3 -3558
SLC3A2 -3537
PSMD9 -3447
ENPP1 -3438
TIMMDC1 -3430
NUDT7 -3409
PFKFB2 -3394
GPC2 -3380
ARNTL -3372
PLCG2 -3353
LDHAL6B -3336
CHAT -3281
CSPG5 -3264
DUOX1 -3261
ST3GAL6 -3239
CERS4 -3237
GPC5 -3235
UMPS -3218
CRLS1 -3175
GLTP -3170
IDH3A -3167
STS -3102
PSMB5 -3070
PNPLA2 -3045
OAZ3 -3034
MLYCD -3021
ADCY2 -3004
HSD17B11 -2969
HSD17B8 -2964
PLD6 -2947
SLC44A3 -2884
MMAA -2868
ALDH1L2 -2854
PTGIS -2850
COX18 -2846
CYP3A43 -2842
CSGALNACT1 -2837
SDHD -2814
CDS1 -2783
PIPOX -2759
IDH1 -2727
CYP26C1 -2720
ADPRM -2701
GLP1R -2622
SARDH -2608
PIK3R6 -2566
ELOVL2 -2560
ZDHHC21 -2529
TKFC -2488
ACO2 -2479
LRP2 -2445
SLCO1B3 -2384
ACOX2 -2364
MOCS3 -2284
PRKG2 -2269
MCEE -2191
AIMP2 -2121
SPTSSA -2119
RRM2 -2096
SMS -2082
HEXB -2074
VDR -2027
GNA15 -2025
CKMT2 -1996
ASS1 -1956
ORMDL3 -1908
MCCC2 -1881
ERCC2 -1870
TCN2 -1863
NCAN -1857
UQCRC1 -1846
NUDT18 -1719
PPT2 -1696
PLCB3 -1691
CYP2W1 -1681
HMOX1 -1679
DBH -1622
MED10 -1589
GYG2 -1578
GBA3 -1556
PLPP1 -1546
NT5C1B -1535
GNA14 -1533
PGAM2 -1527
ALDOB -1505
AKR1A1 -1485
SLC37A2 -1452
MOCS1 -1401
DEGS2 -1394
BGN -1384
AGMO -1376
PPIP5K1 -1371
ACSBG2 -1335
CHST9 -1300
ABCB11 -1287
AKT1 -1284
FITM1 -1272
ARG1 -1253
GCKR -1252
GSTA4 -1250
KHK -1233
PEX11A -1219
UPB1 -1202
SPTLC3 -1196
PIP5K1C -1077
GADL1 -1068
OSBPL6 -1051
NOS3 -1014
SULT1C4 -982
AKR1D1 -918
SULT1A2 -824
GDA -821
BST1 -721
AOC3 -687
FUT6 -628
ADCY4 -619
SLC27A2 -602
STARD3 -562
CYP7B1 -490
PLA2G4E -487
VDAC1 -438
PCK2 -421
STARD6 -413
DSEL -378
PGD -375
SLC25A21 -374
SEPHS2 -372
GLRX -360
PTGDS -346
RDH11 -324
GK -294
DUOX2 -284
HPRT1 -274
GRHL1 -219
ACSBG1 -177
DDO -148
ALOXE3 -83
B3GNT4 -80
GGPS1 -79
CYP4F8 -69
CA5B -63
ACHE -47
AK7 -28
FDXR -11
VNN1 -5
FLVCR1 11
PLBD1 41
PIK3R5 115
CACNB3 139
SHMT2 159
BCKDHB 169
SPTSSB 260
ACOT4 282
GNG4 284
SLC25A17 305
ACSL6 345
CA7 350
CARNS1 352
AGMAT 354
RIMKLB 374
ETFDH 383
POR 404
CKM 416
GGT6 424
FOLH1 481
TAT 484
ALOX15 525
TYMS 552
HYAL1 607
ENPP3 626
ETFB 630
ASRGL1 636
AHCY 685
MED19 726
PSMC6 758
PRSS1 791
RNLS 819
NR1H2 848
DPEP2 859
GLYATL1 876
PSMA5 902
GOT2 920
CYP4V2 946
HSD17B4 965
HIBCH 1060
AOX1 1074
PNPO 1101
HPGD 1104
GLYATL2 1164
CD36 1172
EEF1E1 1190
PIP4K2B 1237
INPP4B 1266
CACNA1E 1285
SLC6A12 1324
PLA1A 1350
FBP2 1360
MED15 1402
FA2H 1404
PSMD10 1419
HMMR 1427
ENTPD5 1518
NT5C1A 1664
BPGM 1718
COQ10B 1729
GNGT2 1761
RPL10 1774
ASPA 1780
HACD1 1783
PANK2 1839
LHB 1865
ADIPOQ 1871
ATIC 1882
MLX 1896
HMOX2 1944
RHD 1974
ENOPH1 1995
ACSM3 2034
AIMP1 2062
TKT 2085
SULT2A1 2110
OMD 2136
PON2 2142
TTR 2169
CD38 2200
CYP27A1 2211
GLB1L 2220
DCT 2256
ENPP2 2264
B3GAT1 2266
PDK2 2295
SLC22A13 2321
PCYT1B 2329
PHYH 2332
KCNG2 2355
NUP88 2407
LDHB 2415
PANK4 2442
AK6 2443
CGA 2473
CA6 2485
PRELP 2503
PLIN1 2524
KYAT1 2571
ITPKA 2588
SLC22A5 2687
CRYM 2820
AKR1B15 2834
CYP4A22 2836
EPM2A 2867
LIPT1 2883
NOSTRIN 2908
PITPNM3 2914
DMAC2L 2983
UGT1A1 2991
FABP2 3053
GLS2 3059
DERA 3130
MAT1A 3243
IDO2 3288
SLC27A3 3291
TTPA 3320
AKAP5 3369
PRXL2B 3410
ACADS 3416
GPX2 3477
INPP1 3495
LRAT 3524
CYP8B1 3574
ADH6 3576
DMGDH 3584
NEU4 3590
SDS 3701
NUDT12 3717
FUT9 3731
UROC1 3745
APOC2 3762
TXN2 3772
SLC52A3 3805
CYP21A2 3842
UGT3A1 3866
MFSD2A 3872
SLC22A1 3976
MED9 4006
CACNA2D2 4022
ALOX5 4036
ACSL5 4060
BRIP1 4063
PLCD4 4108
MIOX 4120
SPNS2 4175
CYP2B6 4191
ADAL 4223
SLC23A1 4246
AZIN2 4266
HNMT 4278
HSD11B2 4286
NDST3 4372
NEU1 4392
PNPLA4 4418
TNFAIP8L3 4426
SULT1B1 4446
PLCB4 4449
SLC26A1 4536
SLC19A3 4543
TDH 4564
NDUFS4 4585
FMO3 4597
GSTT2 4638
SDSL 4704
CTPS1 4799
CTRB2 4842
MOGAT3 4935
SLC5A5 4947
EPHX2 4948
ENPP6 4952
GSTO2 4960
MTARC1 4965
HACD4 4993
FUT3 5011
GBA 5032
PHYKPL 5049
TSPO 5065
VNN2 5068
LIPE 5107
HAL 5227
DARS1 5236
CYP2C19 5242
SLC52A1 5249
MCAT 5259
ACADSB 5287
ETNPPL 5323
ACP5 5341
PXMP2 5356
GCK 5369
HGD 5371
PCK1 5380
PLB1 5405
PLA2G4F 5416
GLO1 5419
CDA 5423
CYP2R1 5424
PLA2G4D 5461
ALOX15B 5476
CTRC 5487
FUT2 5491
NR1D1 5538
PLA2G10 5551
HS3ST4 5557
PISD 5579
AK9 5613
CYP17A1 5640
PLA2G2D 5692
MTMR7 5748
ENTPD6 5766
STAR 5772
PMVK 5813
ISCA2 5842
MED28 5849
MECR 5885
PFKFB1 5921
LIPT2 5927
AUH 5965
IYD 5993
TMEM186 6002
CBSL 6015
ADSL 6016
FABP1 6031
RBKS 6038
MED27 6058
LIPH 6059
GNMT 6067
RPL21 6069
LIAS 6071
ASL 6077
INPP5K 6081
CBR1 6100
ABO 6114
HPD 6118
COX19 6127
AK8 6151
ABCC8 6159
CYP46A1 6176
B3GAT2 6198
PYGM 6201
RPS3A 6205
GPD1L 6210
CYP4F3 6211
CSNK1G2 6213
GNG7 6224
LDHAL6A 6228
ADH5 6252
CYP1A2 6277
SLC51A 6298
HOGA1 6312
SLC25A12 6313
ANKRD1 6358
ACSM2A 6372
AS3MT 6419
HSD17B1 6478
PTDSS2 6491
HS6ST3 6522
RAN 6568
GNPAT 6592
ACAD10 6640
UGT3A2 6659
BAAT 6663
ALDH3B1 6795
CYP39A1 6798
DDAH2 6810
CMBL 6828
BHMT 6861
CYP19A1 6946
TDO2 6977
CYP4B1 7046
PNMT 7066
TPMT 7089
SDHB 7106
CYP1A1 7186
ACACB 7207
CD320 7229
CPS1 7256
AMDHD1 7261
HEXA 7307
MORC2 7314
CYP3A5 7387
FXN 7427
GPD1 7439
INPP5J 7498
GNG10 7536
GPAT2 7550
AKR1C1 7563
ACSM2B 7569
XYLB 7575
CA13 7615
ABCC2 7647
ASAH1 7656
RPS27A 7697
UBE2I 7712
NHLRC1 7736
LHPP 7777
MTAP 7800
AOC1 7868
PPARD 7885
ST3GAL4 7916
SULT1A4 7943
IPPK 7984
CERS1 7985
PLCB2 8012
NUDT13 8043
KYNU 8048
MED30 8059
CHST5 8081
ACOXL 8092
KMO 8135
HS3ST6 8231
KCNB1 8239
PPA2 8258
RPL13A 8281
MANBA 8350
UBC 8359
PSPH 8385
COX14 8403
NAT1 8473
ACSS2 8505
HSD17B7 8539
SRR 8585
AADAT 8658
COQ7 8700
ALB 8745
DEGS1 8746
TPO 8748
MED18 8782
ACAT2 8813
IDO1 8830
PLEKHA6 8898
GPT2 8933
CHAC2 8959
GGT7 8974
HSCB 8979
ADH1B 8993
AMN 9003
PPP1CA 9009
PLA2G5 9011
ACSF2 9017
B4GAT1 9027
SLC5A6 9033
NMNAT3 9071
FAHD1 9129
SLC25A1 9149
ACBD6 9171
NFYB 9179
ME3 9212
GOT1 9229
PECR 9240
SGPP2 9245
B4GALNT1 9247
TPH2 9252
CYP26A1 9268
ADHFE1 9294
HSD17B13 9329
ACY3 9333
LTC4S 9335
PLD4 9338
MED4 9361
RPL3L 9364
CACNA1D 9379
AFMID 9384
CROT 9385
MPC2 9395
MTMR14 9437
MTARC2 9450
FAAH 9454
SERPINA6 9464
DTYMK 9487
SULT1A1 9496
NAALAD2 9503
GSTM3 9520
D2HGDH 9528
TACO1 9552
NUP35 9591
BCAT2 9595
POLD1 9636
STARD5 9653
RAPGEF4 9660
CA3 9671
PEMT 9679
CES3 9703
GGCT 9712
SGSH 9716
PLAAT2 9730
FDX1 9808
GRHPR 9810
CYP2E1 9821
IP6K2 9839
OXCT2 9907
ACADL 9911
PFKFB4 9927
NSDHL 9947
PSMD14 9962
OPLAH 9977
MVK 9991
GSTM1 9994
ACBD4 9995
SLC19A1 9998
HIBADH 10015
APOA1 10020
GLYCTK 10031
ACOT8 10037
OAZ1 10041
APOM 10076
MED6 10080
SAT1 10087
ACOT1 10105
TRAP1 10110
TYMP 10111
PDSS1 10178
SMPD2 10193
PARP10 10208
GSTZ1 10220
NUDT15 10252
NDUFAB1 10262
UGT1A7 10289
PSMD12 10294
PTGR2 10302
CHDH 10303
CERS5 10308
COQ10A 10312
ABCD1 10314
DIO2 10325
FAH 10338
PHOSPHO1 10364
NDUFAF7 10405
ALOX12B 10419
MAOB 10431
GUSB 10432
AMT 10435
RPS2 10438
LPCAT3 10449
FABP6 10457
PRODH 10458
PSMB2 10501
NDUFV1 10505
PSMA6 10525
ABHD14B 10529
SAR1B 10585
PCBD1 10604
RPS29 10608
NT5C2 10612
ADI1 10625
B3GAT3 10634
SURF1 10643
CYP2D6 10651
LPIN3 10654
IDH3G 10660
HAAO 10666
NUP42 10670
GPT 10675
GSTM4 10679
MTHFD2L 10710
AGT 10720
GBA2 10731
TPH1 10734
CYP2J2 10796
ACOT9 10798
DGAT2 10818
GMPR 10846
MMACHC 10850
PSTK 10855
COQ5 10868
PPARG 10907
AKR7L 10909
HYAL3 10926
BLVRB 10949
CHPF2 10960
AGPAT4 10970
HSD17B3 10978
BCO2 10985
NDUFAF1 11010
SLC37A4 11019
SMPD4 11056
RPL22 11069
SLC25A11 11070
SCO2 11075
CYC1 11099
INPP5E 11120
PLPP2 11137
ARSA 11139
NDUFAF4 11158
UCP3 11170
NUP43 11189
SUOX 11196
PHKG1 11197
HSD17B14 11204
PRKACA 11230
SPR 11254
SLC27A5 11270
NDUFAF5 11271
GGT5 11284
PPCS 11299
QPRT 11304
CHST13 11330
KARS1 11331
AKR1B1 11341
TMEM126B 11368
PNPLA7 11395
AKR7A3 11402
HYKK 11407
BLVRA 11409
VAMP2 11429
MRI1 11452
MED25 11454
GCDH 11456
PARP6 11458
GCSH 11466
CACNB2 11488
GSS 11492
APIP 11512
COQ3 11529
GGT1 11546
NAXD 11547
SMPD3 11554
ENTPD8 11587
CPTP 11594
ABCC5 11605
OSBPL7 11638
ECSIT 11668
NUP37 11671
STARD10 11676
ISCU 11686
GUK1 11742
RPS9 11743
CYP26B1 11771
BHMT2 11779
LYRM4 11783
CIAO1 11786
BCHE 11796
SLC25A14 11838
MTHFD1 11859
RPL8 11881
UCK1 11887
COX16 11906
NDUFA9 11918
PFAS 11942
PODXL2 11945
FLAD1 11951
ACOT11 11960
DGAT1 11969
ACBD7 11972
ESYT3 11984
GDPD3 11988
ALAD 11996
NAXE 12002
ACOT2 12006
G0S2 12018
PLEKHA4 12027
GSTM2 12029
NUP85 12061
NDUFAF6 12067
AGK 12094
NT5M 12095
DHODH 12098
GNB3 12099
AGPAT2 12108
FTCD 12109
ENTPD4 12114
CHST12 12115
EBP 12117
PSMA1 12138
N6AMT1 12141
SUCLG1 12157
GNG5 12164
GALT 12193
BPHL 12194
TMEM86B 12218
TST 12222
RPS10 12226
SCLY 12232
COX5A 12243
CYB5A 12244
FDPS 12247
ADPGK 12261
FDX2 12267
ALDH2 12276
CHST14 12280
ESRRA 12285
PSMB9 12294
MED7 12295
PTGES2 12298
COQ2 12329
HYAL2 12361
ABCC3 12400
DUT 12412
ACY1 12414
PLCG1 12415
CH25H 12420
CUBN 12425
NADSYN1 12434
SLC25A10 12439
CYCS 12448
CYB5B 12457
PSMB6 12465
COQ9 12472
ATP5F1E 12512
COX20 12526
HADH 12528
NUDT5 12537
MARS1 12544
SULT1A3 12551
NUBP2 12567
PPCDC 12602
ORMDL1 12612
PSMC2 12636
CYGB 12637
FH 12650
NDUFA5 12663
RPL30 12665
ALDH7A1 12669
ITPK1 12689
MDH1 12702
SIN3B 12713
PHKA2 12714
GSTK1 12722
PSMB8 12723
MLXIPL 12726
CBS 12729
GCAT 12733
ATP5MC3 12746
NR1H3 12749
CKB 12760
ABHD3 12772
NUP107 12782
MMAB 12800
ECHS1 12805
UCP2 12830
EPHX1 12832
PPOX 12837
RPS27 12843
STK11 12865
CHAC1 12880
RIDA 12911
NDUFA4 12919
B3GALT6 12929
THEM4 12942
ACAD9 12951
MPC1 12954
NMRK1 12960
NAPRT 12972
NDUFC2 12983
SMARCD3 12997
TK2 13005
NADK 13012
PSMA4 13022
ACAD8 13049
ENO3 13077
UQCR11 13085
RBP4 13112
TALDO1 13122
RUFY1 13124
MTHFS 13141
COMT 13144
HAGH 13149
PSAT1 13153
RPSA 13154
NDUFB11 13161
GNG11 13162
MGST1 13169
RPS12 13178
IDUA 13198
RPL27 13203
RPS17 13209
LPCAT4 13214
UBA52 13217
AK1 13226
SLC25A19 13230
UROS 13240
PSMB10 13241
SREBF1 13246
RBP1 13272
MGST3 13281
RPL7A 13286
GLRX5 13304
NPAS2 13305
MIGA2 13307
CIAO3 13315
NQO2 13324
ACAA1 13328
PSMD4 13334
DNPH1 13341
AK2 13348
STX1A 13368
MAN2C1 13393
CBR3 13394
PDHA1 13423
AIP 13428
GSTT2B 13432
ECI1 13447
PSME1 13459
RTEL1 13471
NUDT9 13472
ORMDL2 13480
SRM 13483
CKMT1A 13484
RPS23 13488
ITPA 13497
ACAD11 13500
MED11 13505
RPL18A 13507
HSD17B10 13513
G6PC3 13527
RPL39 13544
CPNE1 13546
HMBS 13553
NMRAL1 13593
CSNK2B 13594
SLC25A16 13596
CPNE7 13597
MPST 13602
UBB 13607
DECR1 13609
PSMC5 13624
NDUFB3 13629
PTS 13637
GLA 13642
NQO1 13648
RPL5 13658
SNAP25 13668
BDH2 13676
BDH1 13680
NT5C 13684
NDUFS6 13691
COQ6 13692
DECR2 13694
NUBP1 13704
UCKL1 13717
RPS3 13719
PHKG2 13721
PSMD13 13724
SULT1C2 13728
ACADVL 13729
ABCD4 13732
PDHB 13736
RPL15 13737
NDUFB6 13749
NOSIP 13763
AKR1C3 13775
SHMT1 13776
TK1 13780
UROD 13798
SULT4A1 13799
RPL22L1 13806
PSMD6 13813
GAMT 13815
NDOR1 13819
RPS4X 13824
ARV1 13844
PYCR2 13854
PTGES 13869
COA1 13884
PTPMT1 13886
NDUFV3 13890
NFYC 13897
PSMC3 13913
DBI 13931
ASNS 13935
DHRS7B 13943
NUDT1 13945
RPL11 13968
PLAAT4 13970
AAAS 13971
GPX1 13973
PGLS 13977
DCXR 13987
RPS6 13991
ATP5MC2 13992
NDUFS7 13997
RPS14 14014
MED31 14021
NDUFC1 14023
NDUFB7 14030
TBXAS1 14042
PSMB7 14048
PCYT2 14052
GPCPD1 14058
PSMB1 14066
RPS28 14071
APRT 14079
PGP 14081
TM7SF2 14093
NDUFB2 14098
ATP5F1C 14105
NME2 14120
BSG 14131
PHGDH 14137
RPL4 14145
PSMA3 14148
GPX4 14153
NDUFAF2 14161
CHKA 14168
NDUFB10 14169
DHFR 14173
PLAAT3 14176
RPL13 14186
COX7C 14187
TAZ 14188
GSTP1 14190
MT-ATP8 14192
GNAS 14216
CIAO2B 14217
NME3 14222
PDZD11 14228
RPS13 14240
RPL26 14246
RPL37A 14263
SLC25A28 14264
DGUOK 14265
RPS25 14278
CACNA1A 14284
RPL36AL 14290
MOCS2 14293
ATP5PF 14301
PSMC4 14302
APOE 14309
NDUFS3 14313
PLA2G6 14315
CSAD 14316
RPL6 14318
RPLP1 14319
UQCRH 14321
RPS8 14333
RPS27L 14338
COX8A 14344
GLIPR1 14356
RPL26L1 14358
NDUFS8 14361
ISYNA1 14362
CHKB 14366
SLC25A27 14374
RPL35A 14377
RPL18 14388
NDUFB9 14393
RPL9 14394
GALE 14405
GSTO1 14425
NDUFA11 14439
ATP5PO 14446
NNMT 14452
RPL36 14456
PSME2 14457
GPS2 14465
RPS19 14476
NDUFA8 14488
NDUFA6 14489
NME4 14492
RPS15 14496
RPL17 14497
RPL19 14499
RPL29 14503
UQCR10 14508
RPL23 14510
UQCRB 14511
RPS11 14523
RPS16 14529
TECR 14536
SLC25A37 14540
TXN 14545
MGST2 14546
RPL28 14550
COX6C 14553
NDUFA13 14559
RPS7 14564
ATP5F1D 14567
RPL32 14571
RPS18 14572
ATP5MC1 14573
RPS15A 14577
RPL12 14580
RPL24 14583
RPL34 14584
PSMB4 14586
RPLP2 14587
NDUFB4 14596
RPL36A 14597
CPT1B 14599
MT-ND5 14600
COX4I1 14604
MT-ATP6 14606
RPS21 14610
ACOT13 14612
RPS24 14622
NDUFB8 14627
MT-ND6 14633
NDUFA12 14636
RPL27A 14639
TRMT112 14645
FABP5 14646
ATP5MG 14649
PLA2G4B 14652
ATP5MF 14664
PSMB3 14666
NDUFA3 14672
CES1 14675
RPS20 14683
RPL35 14685
COX6A1 14689
FAU 14690
SEM1 14696
NDUFAF3 14700
RPS26 14702
NDUFA2 14713
NDUFA1 14715
RPL31 14719
COX6B1 14720
RPL37 14722
ATP5ME 14724
RPL14 14725
RPL38 14728
NDUFA7 14731
NDUFS5 14733
UQCRQ 14735
NDUFV2 14736
COX5B 14737
ATP5PD 14740
NME1 14741
COX7B 14749
NDUFB1 14751
MT-ND4 14762
MT-CO3 14764
MT-ND1 14765
MT-CO1 14766
MT-CO2 14768
MT-ND3 14769
MT-ND2 14771
MT-CYB 14772


Oxidative Stress Induced Senescence

Oxidative Stress Induced Senescence
15
set Oxidative Stress Induced Senescence
setSize 83
pANOVA 0.643
s.dist -0.0294
p.adjustANOVA 0.671



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK1 -11008
CDK6 -10806
TNIK -10150
PHC3 -10026
RNF2 -9832
BMI1 -9665
PHC2 -9553
MAPKAPK3 -9526
MAPK3 -9373
MAP2K4 -9128
MAP4K4 -8868
TNRC6B -8847
MAP3K5 -8575
MAP2K7 -8536
AGO3 -8484
MINK1 -8250
KDM6B -8163
MAPKAPK2 -8013
AGO4 -7827
MAPK14 -7640

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -11008.0
CDK6 -10806.0
TNIK -10150.0
PHC3 -10026.0
RNF2 -9832.0
BMI1 -9665.0
PHC2 -9553.0
MAPKAPK3 -9526.0
MAPK3 -9373.0
MAP2K4 -9128.0
MAP4K4 -8868.0
TNRC6B -8847.0
MAP3K5 -8575.0
MAP2K7 -8536.0
AGO3 -8484.0
MINK1 -8250.0
KDM6B -8163.0
MAPKAPK2 -8013.0
AGO4 -7827.0
MAPK14 -7640.0
AGO1 -6821.0
RBBP7 -6358.0
MAPK9 -6116.0
MAPK8 -5949.0
CBX6 -5924.0
TNRC6C -5761.0
MDM2 -5708.0
H2AC6 -5672.0
TNRC6A -5504.0
CBX4 -5298.0
CBX2 -5230.0
H2BC12 -5229.0
RBBP4 -4584.0
TFDP1 -4386.0
MAPKAPK5 -4066.0
CDKN2D -3525.0
CDKN2C -3461.0
H2BC15 -2733.0
E2F3 -2585.0
EED -1655.0
MAP2K3 774.0
TFDP2 985.0
H2AC18 1911.0
H3C1 3171.0
H2AB1 3456.0
H2AC7 4317.0
H2BC4 4759.0
H2BC13 4801.0
H2BC11 4918.0
MAPK11 4949.0
PHC1 5685.0
H2BC21 6192.0
CDK4 6337.0
MAPK10 7078.0
H2AC14 7113.0
SCMH1 7371.0
H2BC17 7486.0
JUN 7504.0
RPS27A 7697.0
H2BU1 7988.0
UBC 8359.0
H3C15 9115.5
H2BC9 9248.0
MAP2K6 10393.0
H2AZ2 11408.0
SUZ12 11477.0
MDM4 11574.0
TP53 11698.0
E2F2 12028.0
CBX8 12046.0
MOV10 12123.0
H2AZ1 12183.0
H2BC5 12839.0
RING1 13065.0
UBA52 13217.0
FOS 13319.0
UBB 13607.0
E2F1 13912.0
H3-3A 13915.0
H2AC20 14061.0
EZH2 14297.0
H2AJ 14469.0
TXN 14545.0


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.8         
##  [49] XML_3.99-0.9           sass_0.4.0             dbplyr_2.1.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.2            later_1.3.0           
##  [58] AnnotationDbi_1.54.1   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.0            cachem_1.0.6           cli_3.2.0             
##  [64] generics_0.1.2         RSQLite_2.2.10         broom_0.7.12          
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.37             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.32.0        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.0         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.70.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] desc_1.4.1             lattice_0.20-45        Matrix_1.4-1          
##  [88] vctrs_0.3.8            pillar_1.7.0           lifecycle_1.0.1       
##  [91] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [94] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [97] KernSmooth_2.23-20     gridExtra_2.3          assertthat_0.2.1      
## [100] rprojroot_2.0.2        withr_2.5.0            GenomeInfoDbData_1.2.6
## [103] hms_1.1.1              grid_4.2.0             rmarkdown_2.13        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report