Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-05-10
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## KO drug
## 5_8S_rRNA -0.4520464 13.3743116
## 7SK -2.2982399 8.2273688
## A1BG -3.3008939 6.5686329
## A1BG-AS1 0.3211569 2.0364019
## A1CF -0.7352419 -0.3353024
## A2M 30.2687300 -19.6842209| Profile metrics | |
|---|---|
| num_genes_in_profile | 24473 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 2698 |
| num_profile_genes_not_in_sets | 21775 |
| profile_pearson_correl | 0.06908 |
| profile_spearman_correl | 0.09129 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets:| Gene sets metrics | |
|---|---|
| num_genesets | 24 |
| num_genesets_excluded | 0 |
| num_genesets_included | 24 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 24 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 24 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.KO | s.drug | p.KO | p.drug |
|---|---|---|---|---|---|---|---|---|
| Mucopolysaccharidoses | 11 | 1.36e-05 | 2.71e-05 | 0.799 | 0.7560 | -0.2580 | 1.41e-05 | 1.38e-01 |
| Reduction of cytosolic Ca++ levels | 12 | 1.99e-04 | 2.80e-04 | 0.656 | 0.4230 | -0.5020 | 1.12e-02 | 2.59e-03 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 1.73e-04 | 2.77e-04 | 0.635 | -0.4370 | 0.4620 | 6.39e-03 | 3.96e-03 |
| Complex I biogenesis | 57 | 8.21e-22 | 6.57e-21 | 0.740 | -0.1230 | 0.7290 | 1.09e-01 | 1.49e-21 |
| Respiratory electron transport | 103 | 4.70e-27 | 5.64e-26 | 0.610 | -0.1600 | 0.5890 | 4.90e-03 | 4.56e-25 |
| Cellular response to starvation | 150 | 2.14e-29 | 5.15e-28 | 0.518 | -0.3220 | 0.4060 | 9.62e-12 | 9.26e-18 |
| Stabilization of p53 | 53 | 9.56e-11 | 2.87e-10 | 0.515 | -0.4250 | 0.2910 | 8.54e-08 | 2.43e-04 |
| Mitochondrial translation | 96 | 6.75e-20 | 4.05e-19 | 0.539 | -0.1480 | 0.5180 | 1.21e-02 | 1.55e-18 |
| Mitochondrial protein import | 64 | 2.31e-07 | 5.55e-07 | 0.382 | -0.2030 | 0.3240 | 4.91e-03 | 7.42e-06 |
| Receptor Mediated Mitophagy | 11 | 2.63e-05 | 4.86e-05 | 0.819 | -0.7760 | -0.2630 | 8.30e-06 | 1.31e-01 |
| Mitophagy | 28 | 6.80e-06 | 1.48e-05 | 0.535 | -0.5320 | -0.0476 | 1.07e-06 | 6.63e-01 |
| Metabolism of amino acids and derivatives | 337 | 1.43e-18 | 6.85e-18 | 0.275 | -0.1450 | 0.2340 | 5.01e-06 | 1.59e-13 |
| Diseases of carbohydrate metabolism | 30 | 8.99e-03 | 9.38e-03 | 0.320 | 0.3190 | -0.0263 | 2.49e-03 | 8.03e-01 |
| PTEN Regulation | 140 | 1.48e-08 | 3.96e-08 | 0.302 | -0.2830 | -0.1050 | 7.59e-09 | 3.12e-02 |
| Gene Silencing by RNA | 95 | 1.97e-04 | 2.80e-04 | 0.250 | -0.2410 | -0.0668 | 4.88e-05 | 2.60e-01 |
| Nucleotide biosynthesis | 12 | 3.67e-03 | 4.20e-03 | 0.581 | -0.4820 | -0.3240 | 3.83e-03 | 5.17e-02 |
| Oxidative Stress Induced Senescence | 82 | 2.85e-02 | 2.85e-02 | 0.172 | -0.1700 | -0.0223 | 7.68e-03 | 7.26e-01 |
| Mitochondrial biogenesis | 91 | 6.45e-04 | 8.15e-04 | 0.239 | -0.2230 | -0.0841 | 2.29e-04 | 1.65e-01 |
| Phospholipid metabolism | 186 | 3.53e-12 | 1.41e-11 | 0.319 | -0.1470 | -0.2830 | 5.25e-04 | 2.57e-11 |
| Signaling by the B Cell Receptor (BCR) | 106 | 5.99e-05 | 1.03e-04 | 0.255 | -0.2340 | -0.1020 | 3.07e-05 | 6.99e-02 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 1.75e-03 | 2.10e-03 | 0.298 | -0.2350 | -0.1830 | 3.34e-03 | 2.25e-02 |
| Nervous system development | 522 | 8.27e-12 | 2.83e-11 | 0.190 | -0.1190 | -0.1490 | 3.47e-06 | 5.53e-09 |
| Metabolism | 1856 | 4.20e-04 | 5.60e-04 | 0.057 | -0.0501 | -0.0270 | 3.24e-04 | 5.24e-02 |
| Resolution of D-Loop Structures | 33 | 3.94e-03 | 4.30e-03 | 0.350 | 0.2410 | 0.2530 | 1.66e-02 | 1.18e-02 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.KO | s.drug | p.KO | p.drug |
|---|---|---|---|---|---|---|---|---|
| Mucopolysaccharidoses | 11 | 1.36e-05 | 2.71e-05 | 0.799 | 0.7560 | -0.2580 | 1.41e-05 | 1.38e-01 |
| Reduction of cytosolic Ca++ levels | 12 | 1.99e-04 | 2.80e-04 | 0.656 | 0.4230 | -0.5020 | 1.12e-02 | 2.59e-03 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 1.73e-04 | 2.77e-04 | 0.635 | -0.4370 | 0.4620 | 6.39e-03 | 3.96e-03 |
| Complex I biogenesis | 57 | 8.21e-22 | 6.57e-21 | 0.740 | -0.1230 | 0.7290 | 1.09e-01 | 1.49e-21 |
| Respiratory electron transport | 103 | 4.70e-27 | 5.64e-26 | 0.610 | -0.1600 | 0.5890 | 4.90e-03 | 4.56e-25 |
| Cellular response to starvation | 150 | 2.14e-29 | 5.15e-28 | 0.518 | -0.3220 | 0.4060 | 9.62e-12 | 9.26e-18 |
| Stabilization of p53 | 53 | 9.56e-11 | 2.87e-10 | 0.515 | -0.4250 | 0.2910 | 8.54e-08 | 2.43e-04 |
| Mitochondrial translation | 96 | 6.75e-20 | 4.05e-19 | 0.539 | -0.1480 | 0.5180 | 1.21e-02 | 1.55e-18 |
| Mitochondrial protein import | 64 | 2.31e-07 | 5.55e-07 | 0.382 | -0.2030 | 0.3240 | 4.91e-03 | 7.42e-06 |
| Receptor Mediated Mitophagy | 11 | 2.63e-05 | 4.86e-05 | 0.819 | -0.7760 | -0.2630 | 8.30e-06 | 1.31e-01 |
| Mitophagy | 28 | 6.80e-06 | 1.48e-05 | 0.535 | -0.5320 | -0.0476 | 1.07e-06 | 6.63e-01 |
| Metabolism of amino acids and derivatives | 337 | 1.43e-18 | 6.85e-18 | 0.275 | -0.1450 | 0.2340 | 5.01e-06 | 1.59e-13 |
| Diseases of carbohydrate metabolism | 30 | 8.99e-03 | 9.38e-03 | 0.320 | 0.3190 | -0.0263 | 2.49e-03 | 8.03e-01 |
| PTEN Regulation | 140 | 1.48e-08 | 3.96e-08 | 0.302 | -0.2830 | -0.1050 | 7.59e-09 | 3.12e-02 |
| Gene Silencing by RNA | 95 | 1.97e-04 | 2.80e-04 | 0.250 | -0.2410 | -0.0668 | 4.88e-05 | 2.60e-01 |
| Nucleotide biosynthesis | 12 | 3.67e-03 | 4.20e-03 | 0.581 | -0.4820 | -0.3240 | 3.83e-03 | 5.17e-02 |
| Oxidative Stress Induced Senescence | 82 | 2.85e-02 | 2.85e-02 | 0.172 | -0.1700 | -0.0223 | 7.68e-03 | 7.26e-01 |
| Mitochondrial biogenesis | 91 | 6.45e-04 | 8.15e-04 | 0.239 | -0.2230 | -0.0841 | 2.29e-04 | 1.65e-01 |
| Phospholipid metabolism | 186 | 3.53e-12 | 1.41e-11 | 0.319 | -0.1470 | -0.2830 | 5.25e-04 | 2.57e-11 |
| Signaling by the B Cell Receptor (BCR) | 106 | 5.99e-05 | 1.03e-04 | 0.255 | -0.2340 | -0.1020 | 3.07e-05 | 6.99e-02 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 1.75e-03 | 2.10e-03 | 0.298 | -0.2350 | -0.1830 | 3.34e-03 | 2.25e-02 |
| Nervous system development | 522 | 8.27e-12 | 2.83e-11 | 0.190 | -0.1190 | -0.1490 | 3.47e-06 | 5.53e-09 |
| Metabolism | 1856 | 4.20e-04 | 5.60e-04 | 0.057 | -0.0501 | -0.0270 | 3.24e-04 | 5.24e-02 |
| Resolution of D-Loop Structures | 33 | 3.94e-03 | 4.30e-03 | 0.350 | 0.2410 | 0.2530 | 1.66e-02 | 1.18e-02 |
Detailed Gene set reports
Mucopolysaccharidoses
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 1.36e-05 |
| p.adjustMANOVA | 2.71e-05 |
| s.dist | 0.799 |
| s.KO | 0.756 |
| s.drug | -0.258 |
| p.KO | 1.41e-05 |
| p.drug | 0.138 |
| Gene | KO | drug |
|---|---|---|
| GNS | 11099 | -11125 |
| GLB1 | 10162 | -9240 |
| ARSB | 12086 | -7494 |
| IDS | 8178 | -10132 |
| GALNS | 11751 | -6370 |
| NAGLU | 12163 | -5299 |
| HGSNAT | 6442 | -3959 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ARSB | 12086 | -7494 |
| GALNS | 11751 | -6370 |
| GLB1 | 10162 | -9240 |
| GNS | 11099 | -11125 |
| GUSB | 9430 | 8910 |
| HGSNAT | 6442 | -3959 |
| HYAL1 | 4794 | 556 |
| IDS | 8178 | -10132 |
| IDUA | 11538 | 11620 |
| NAGLU | 12163 | -5299 |
| SGSH | 11466 | 8231 |
Reduction of cytosolic Ca++ levels
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000199 |
| p.adjustMANOVA | 0.00028 |
| s.dist | 0.656 |
| s.KO | 0.423 |
| s.drug | -0.502 |
| p.KO | 0.0112 |
| p.drug | 0.00259 |
| Gene | KO | drug |
|---|---|---|
| ATP2A3 | 12011 | -9206 |
| ATP2B4 | 7929 | -11266 |
| SLC8A2 | 11131 | -7612 |
| ATP2A2 | 7536 | -11089 |
| SLC8A3 | 12029 | -6726 |
| CALM1 | 11329 | -6948 |
| ATP2B1 | 6952 | -10931 |
| SLC8A1 | 10101 | -6530 |
| ATP2B2 | 1355 | -2448 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ATP2A1 | -7073 | 10801 |
| ATP2A2 | 7536 | -11089 |
| ATP2A3 | 12011 | -9206 |
| ATP2B1 | 6952 | -10931 |
| ATP2B2 | 1355 | -2448 |
| ATP2B3 | 5288 | 7244 |
| ATP2B4 | 7929 | -11266 |
| CALM1 | 11329 | -6948 |
| SLC8A1 | 10101 | -6530 |
| SLC8A2 | 11131 | -7612 |
| SLC8A3 | 12029 | -6726 |
| SRI | -8466 | -7625 |
Mitochondrial iron-sulfur cluster biogenesis
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.000173 |
| p.adjustMANOVA | 0.000277 |
| s.dist | 0.635 |
| s.KO | -0.437 |
| s.drug | 0.462 |
| p.KO | 0.00639 |
| p.drug | 0.00396 |
| Gene | KO | drug |
|---|---|---|
| SLC25A37 | -9868 | 12952 |
| GLRX5 | -9519 | 11726 |
| HSCB | -10466 | 7562 |
| FDX1 | -8625 | 8318 |
| ISCU | -6298 | 10132 |
| FDX2 | -5678 | 10706 |
| LYRM4 | -3448 | 10228 |
| SLC25A28 | -2674 | 12676 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| FDX1 | -8625 | 8318 |
| FDX2 | -5678 | 10706 |
| FDXR | 6797 | -10 |
| FXN | 3001 | 6244 |
| GLRX5 | -9519 | 11726 |
| HSCB | -10466 | 7562 |
| ISCA1 | -7587 | -4971 |
| ISCA2 | 2253 | 4958 |
| ISCU | -6298 | 10132 |
| LYRM4 | -3448 | 10228 |
| NFS1 | -8587 | -4816 |
| SLC25A28 | -2674 | 12676 |
| SLC25A37 | -9868 | 12952 |
Complex I biogenesis
| metric | value |
|---|---|
| setSize | 57 |
| pMANOVA | 8.21e-22 |
| p.adjustMANOVA | 6.57e-21 |
| s.dist | 0.74 |
| s.KO | -0.123 |
| s.drug | 0.729 |
| p.KO | 0.109 |
| p.drug | 1.49e-21 |
| Gene | KO | drug |
|---|---|---|
| NDUFA6 | -10640 | 12901 |
| NDUFB10 | -9687 | 12582 |
| NDUFA8 | -8774 | 12900 |
| NDUFS3 | -8653 | 12725 |
| NDUFB9 | -8544 | 12805 |
| NDUFS8 | -7989 | 12773 |
| NDUFB6 | -8238 | 12165 |
| NDUFAB1 | -10558 | 8746 |
| NDUFV2 | -6865 | 13148 |
| NDUFC1 | -7186 | 12437 |
| NDUFAF4 | -8760 | 9608 |
| NDUFS5 | -6394 | 13145 |
| NDUFV3 | -6779 | 12304 |
| NDUFB11 | -7090 | 11583 |
| NDUFA1 | -6222 | 13127 |
| TMEM126B | -8036 | 9815 |
| NDUFS6 | -6327 | 12108 |
| NDUFA5 | -6593 | 11094 |
| NDUFAF2 | -5167 | 12574 |
| ECSIT | -6333 | 10114 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ACAD9 | 12457 | 11377 |
| COA1 | 11438 | 12298 |
| ECSIT | -6333 | 10114 |
| MT-ND1 | 5209 | 13177 |
| MT-ND2 | -1457 | 13183 |
| MT-ND3 | 6571 | 13181 |
| MT-ND4 | 566 | 13174 |
| MT-ND5 | 4289 | 13012 |
| MT-ND6 | 4676 | 13045 |
| NDUFA1 | -6222 | 13127 |
| NDUFA10 | -7241 | -4285 |
| NDUFA11 | 9807 | 12851 |
| NDUFA12 | 6720 | 13048 |
| NDUFA13 | -4424 | 12971 |
| NDUFA2 | 5937 | 13125 |
| NDUFA3 | -4508 | 13084 |
| NDUFA5 | -6593 | 11094 |
| NDUFA6 | -10640 | 12901 |
| NDUFA7 | 8872 | 13143 |
| NDUFA8 | -8774 | 12900 |
| NDUFA9 | 2605 | 10360 |
| NDUFAB1 | -10558 | 8746 |
| NDUFAF1 | 2883 | 9463 |
| NDUFAF2 | -5167 | 12574 |
| NDUFAF3 | 10175 | 13112 |
| NDUFAF4 | -8760 | 9608 |
| NDUFAF5 | -3460 | 9719 |
| NDUFAF6 | -5625 | 10508 |
| NDUFAF7 | 6751 | 8883 |
| NDUFB1 | 8092 | 13163 |
| NDUFB10 | -9687 | 12582 |
| NDUFB11 | -7090 | 11583 |
| NDUFB2 | 11367 | 12511 |
| NDUFB3 | 1661 | 12046 |
| NDUFB4 | 8888 | 13008 |
| NDUFB5 | -3244 | -5075 |
| NDUFB6 | -8238 | 12165 |
| NDUFB7 | -4205 | 12444 |
| NDUFB8 | 8367 | 13039 |
| NDUFB9 | -8544 | 12805 |
| NDUFC1 | -7186 | 12437 |
| NDUFC2 | -5184 | 11409 |
| NDUFS1 | -9609 | -7041 |
| NDUFS2 | 3967 | -10068 |
| NDUFS3 | -8653 | 12725 |
| NDUFS4 | 6388 | 3949 |
| NDUFS5 | -6394 | 13145 |
| NDUFS6 | -6327 | 12108 |
| NDUFS7 | 5531 | 12411 |
| NDUFS8 | -7989 | 12773 |
| NDUFV1 | -5404 | 8980 |
| NDUFV2 | -6865 | 13148 |
| NDUFV3 | -6779 | 12304 |
| NUBPL | 8039 | -8010 |
| TIMMDC1 | 9211 | -3329 |
| TMEM126B | -8036 | 9815 |
| TMEM186 | -8187 | 5086 |
Respiratory electron transport
| metric | value |
|---|---|
| setSize | 103 |
| pMANOVA | 4.7e-27 |
| p.adjustMANOVA | 5.64e-26 |
| s.dist | 0.61 |
| s.KO | -0.16 |
| s.drug | 0.589 |
| p.KO | 0.0049 |
| p.drug | 4.56e-25 |
| Gene | KO | drug |
|---|---|---|
| NDUFA6 | -10640 | 12901 |
| NDUFB10 | -9687 | 12582 |
| COX6B1 | -9124 | 13132 |
| UQCR10 | -9028 | 12920 |
| NDUFA8 | -8774 | 12900 |
| NDUFS3 | -8653 | 12725 |
| NDUFB9 | -8544 | 12805 |
| UQCRH | -8039 | 12733 |
| NDUFS8 | -7989 | 12773 |
| COX20 | -9184 | 10961 |
| NDUFB6 | -8238 | 12165 |
| COX7B | -7400 | 13161 |
| TRAP1 | -11197 | 8602 |
| SCO2 | -9739 | 9526 |
| NDUFAB1 | -10558 | 8746 |
| COX8A | -7227 | 12756 |
| NDUFV2 | -6865 | 13148 |
| NDUFC1 | -7186 | 12437 |
| COX5B | -6531 | 13149 |
| NDUFAF4 | -8760 | 9608 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ACAD9 | 12457 | 11377 |
| COA1 | 11438 | 12298 |
| COQ10A | 2060 | 8793 |
| COQ10B | -11071 | 1561 |
| COX11 | 3872 | -3998 |
| COX14 | -5296 | 7054 |
| COX16 | -4741 | 10348 |
| COX18 | -7574 | -2747 |
| COX19 | 5255 | 5188 |
| COX20 | -9184 | 10961 |
| COX4I1 | -1716 | 13016 |
| COX5A | 8620 | 10682 |
| COX5B | -6531 | 13149 |
| COX6A1 | -1616 | 13101 |
| COX6B1 | -9124 | 13132 |
| COX6C | 5468 | 12965 |
| COX7A2L | -5446 | -8229 |
| COX7B | -7400 | 13161 |
| COX7C | 9483 | 12599 |
| COX8A | -7227 | 12756 |
| CYC1 | -8796 | 9550 |
| CYCS | -2044 | 10884 |
| ECSIT | -6333 | 10114 |
| ETFA | -3727 | -7917 |
| ETFB | -10912 | 576 |
| ETFDH | 2376 | 356 |
| LRPPRC | -7531 | -9086 |
| MT-CO1 | 9067 | 13178 |
| MT-CO2 | 8603 | 13180 |
| MT-CO3 | 8245 | 13176 |
| MT-CYB | 5991 | 13184 |
| MT-ND1 | 5209 | 13177 |
| MT-ND2 | -1457 | 13183 |
| MT-ND3 | 6571 | 13181 |
| MT-ND4 | 566 | 13174 |
| MT-ND5 | 4289 | 13012 |
| MT-ND6 | 4676 | 13045 |
| NDUFA1 | -6222 | 13127 |
| NDUFA10 | -7241 | -4285 |
| NDUFA11 | 9807 | 12851 |
| NDUFA12 | 6720 | 13048 |
| NDUFA13 | -4424 | 12971 |
| NDUFA2 | 5937 | 13125 |
| NDUFA3 | -4508 | 13084 |
| NDUFA4 | 9132 | 11345 |
| NDUFA5 | -6593 | 11094 |
| NDUFA6 | -10640 | 12901 |
| NDUFA7 | 8872 | 13143 |
| NDUFA8 | -8774 | 12900 |
| NDUFA9 | 2605 | 10360 |
| NDUFAB1 | -10558 | 8746 |
| NDUFAF1 | 2883 | 9463 |
| NDUFAF2 | -5167 | 12574 |
| NDUFAF3 | 10175 | 13112 |
| NDUFAF4 | -8760 | 9608 |
| NDUFAF5 | -3460 | 9719 |
| NDUFAF6 | -5625 | 10508 |
| NDUFAF7 | 6751 | 8883 |
| NDUFB1 | 8092 | 13163 |
| NDUFB10 | -9687 | 12582 |
| NDUFB11 | -7090 | 11583 |
| NDUFB2 | 11367 | 12511 |
| NDUFB3 | 1661 | 12046 |
| NDUFB4 | 8888 | 13008 |
| NDUFB5 | -3244 | -5075 |
| NDUFB6 | -8238 | 12165 |
| NDUFB7 | -4205 | 12444 |
| NDUFB8 | 8367 | 13039 |
| NDUFB9 | -8544 | 12805 |
| NDUFC1 | -7186 | 12437 |
| NDUFC2 | -5184 | 11409 |
| NDUFS1 | -9609 | -7041 |
| NDUFS2 | 3967 | -10068 |
| NDUFS3 | -8653 | 12725 |
| NDUFS4 | 6388 | 3949 |
| NDUFS5 | -6394 | 13145 |
| NDUFS6 | -6327 | 12108 |
| NDUFS7 | 5531 | 12411 |
| NDUFS8 | -7989 | 12773 |
| NDUFV1 | -5404 | 8980 |
| NDUFV2 | -6865 | 13148 |
| NDUFV3 | -6779 | 12304 |
| NUBPL | 8039 | -8010 |
| SCO1 | -10631 | -6537 |
| SCO2 | -9739 | 9526 |
| SDHA | -10480 | -9986 |
| SDHB | -299 | 5982 |
| SDHC | 9345 | -5559 |
| SDHD | -9641 | -2716 |
| SURF1 | 8003 | 9112 |
| TACO1 | 8239 | 8081 |
| TIMMDC1 | 9211 | -3329 |
| TMEM126B | -8036 | 9815 |
| TMEM186 | -8187 | 5086 |
| TRAP1 | -11197 | 8602 |
| UQCR10 | -9028 | 12920 |
| UQCR11 | -5675 | 11509 |
| UQCRB | -979 | 12923 |
| UQCRC1 | 8588 | -1762 |
| UQCRC2 | -11089 | -6026 |
| UQCRFS1 | -10915 | -8657 |
| UQCRH | -8039 | 12733 |
| UQCRQ | 10244 | 13147 |
Cellular response to starvation
| metric | value |
|---|---|
| setSize | 150 |
| pMANOVA | 2.14e-29 |
| p.adjustMANOVA | 5.15e-28 |
| s.dist | 0.518 |
| s.KO | -0.322 |
| s.drug | 0.406 |
| p.KO | 9.62e-12 |
| p.drug | 9.26e-18 |
| Gene | KO | drug |
|---|---|---|
| ASNS | -10878 | 12349 |
| RPL22L1 | -10448 | 12221 |
| RPL9 | -9659 | 12806 |
| ATP6V1F | -9621 | 12853 |
| RPS17 | -10534 | 11631 |
| RPL34 | -9357 | 12996 |
| RPL12 | -9329 | 12992 |
| RPL26L1 | -9387 | 12770 |
| RPS13 | -9450 | 12652 |
| RPS25 | -9371 | 12690 |
| RPL37A | -9347 | 12675 |
| RPS18 | -9122 | 12984 |
| RPL17 | -8989 | 12909 |
| TCIRG1 | -9563 | 12083 |
| RPL31 | -8781 | 13131 |
| RPS6 | -9225 | 12405 |
| RPS15A | -8754 | 12989 |
| RPL36 | -8818 | 12868 |
| FAU | -8610 | 13102 |
| RPL26 | -8797 | 12658 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ASNS | -10878 | 12349 |
| ATF2 | -8942 | -9289 |
| ATF3 | -4081 | -4353 |
| ATF4 | -6768 | 11948 |
| ATP6V0B | -8190 | 12175 |
| ATP6V0C | -8240 | 10022 |
| ATP6V0D1 | 11801 | -8213 |
| ATP6V0D2 | -9542 | 2965 |
| ATP6V0E1 | -8440 | 12436 |
| ATP6V0E2 | 12829 | 7103 |
| ATP6V1A | 9802 | -8760 |
| ATP6V1B1 | 8282 | 12811 |
| ATP6V1B2 | -11084 | -9848 |
| ATP6V1C1 | 8273 | -8400 |
| ATP6V1C2 | 3667 | 10275 |
| ATP6V1D | 2442 | 246 |
| ATP6V1E1 | -8985 | -897 |
| ATP6V1E2 | 9261 | 830 |
| ATP6V1F | -9621 | 12853 |
| ATP6V1G1 | -5949 | 11369 |
| ATP6V1G2 | 8440 | 1464 |
| ATP6V1H | 8359 | -481 |
| BMT2 | -8111 | -8436 |
| CEBPB | -7116 | 12656 |
| CEBPG | -9940 | 6581 |
| DDIT3 | -9395 | 10987 |
| DEPDC5 | -57 | -3609 |
| EIF2AK4 | 10865 | -7766 |
| EIF2S1 | -8950 | -8774 |
| EIF2S2 | -10653 | -6089 |
| EIF2S3 | -10174 | -5022 |
| FAU | -8610 | 13102 |
| FLCN | -11166 | -4240 |
| FNIP1 | -10267 | -9342 |
| FNIP2 | 4906 | -9706 |
| GCN1 | 10665 | -8257 |
| IMPACT | -1732 | -8127 |
| ITFG2 | 9671 | 12398 |
| KPTN | 8095 | 10246 |
| LAMTOR1 | -5671 | -7722 |
| LAMTOR2 | 5420 | 10180 |
| LAMTOR3 | -2587 | 6218 |
| LAMTOR4 | -8066 | 10839 |
| LAMTOR5 | 6245 | 11081 |
| MIOS | -9468 | -7857 |
| MLST8 | -10314 | -4897 |
| MTOR | 8963 | -5908 |
| NPRL2 | -5122 | 12562 |
| NPRL3 | -10528 | 4401 |
| RHEB | 11691 | 4362 |
| RPL10 | -3821 | 1597 |
| RPL10A | -9707 | -8212 |
| RPL11 | -8529 | 12382 |
| RPL12 | -9329 | 12992 |
| RPL13 | -3469 | 12598 |
| RPL13A | -6854 | 6955 |
| RPL14 | -6386 | 13137 |
| RPL15 | -786 | 12153 |
| RPL17 | -8989 | 12909 |
| RPL18 | -6672 | 12800 |
| RPL18A | -6976 | 11926 |
| RPL19 | 3924 | 12911 |
| RPL21 | -6322 | 5141 |
| RPL22 | -5554 | 9520 |
| RPL22L1 | -10448 | 12221 |
| RPL23 | 5769 | 12922 |
| RPL23A | 11361 | -5257 |
| RPL24 | -4591 | 12995 |
| RPL26 | -8797 | 12658 |
| RPL26L1 | -9387 | 12770 |
| RPL27 | 6735 | 11625 |
| RPL27A | -7818 | 13051 |
| RPL28 | -5809 | 12962 |
| RPL29 | -4515 | 12915 |
| RPL3 | -6827 | -4535 |
| RPL30 | -3907 | 11096 |
| RPL31 | -8781 | 13131 |
| RPL32 | -5028 | 12983 |
| RPL34 | -9357 | 12996 |
| RPL35 | -8027 | 13097 |
| RPL35A | -1449 | 12789 |
| RPL36 | -8818 | 12868 |
| RPL36A | -4480 | 13009 |
| RPL36AL | -8216 | 12702 |
| RPL37 | -4624 | 13134 |
| RPL37A | -9347 | 12675 |
| RPL38 | 1558 | 13140 |
| RPL39 | -6168 | 11962 |
| RPL39L | -6608 | -6269 |
| RPL3L | -510 | 7904 |
| RPL4 | 11351 | 12558 |
| RPL41 | -4616 | -6074 |
| RPL5 | 4679 | 12075 |
| RPL6 | -6903 | 12730 |
| RPL7 | -3327 | -8789 |
| RPL7A | -6163 | 11708 |
| RPL8 | -7572 | 10323 |
| RPL9 | -9659 | 12806 |
| RPLP0 | -1504 | -7331 |
| RPLP1 | 9026 | 12731 |
| RPLP2 | -8225 | 12999 |
| RPS10 | -8384 | 10665 |
| RPS11 | -7725 | 12935 |
| RPS12 | -7872 | 11600 |
| RPS13 | -9450 | 12652 |
| RPS14 | -1180 | 12428 |
| RPS15 | -7430 | 12908 |
| RPS15A | -8754 | 12989 |
| RPS16 | -3844 | 12941 |
| RPS17 | -10534 | 11631 |
| RPS18 | -9122 | 12984 |
| RPS19 | -7633 | 12888 |
| RPS2 | -10222 | 8916 |
| RPS20 | -4961 | 13095 |
| RPS21 | -3001 | 13022 |
| RPS23 | 6940 | 11907 |
| RPS24 | 2369 | 13034 |
| RPS25 | -9371 | 12690 |
| RPS26 | -2615 | 13114 |
| RPS27 | 651 | 11270 |
| RPS27A | 5357 | 6464 |
| RPS27L | 7330 | 12750 |
| RPS28 | 2716 | 12485 |
| RPS29 | -652 | 9078 |
| RPS3 | -7756 | 12135 |
| RPS3A | -9170 | 5257 |
| RPS4X | -8542 | 12239 |
| RPS5 | -6283 | -7965 |
| RPS6 | -9225 | 12405 |
| RPS7 | 5142 | 12976 |
| RPS8 | -5812 | 12745 |
| RPS9 | -8815 | 10189 |
| RPSA | 292 | 11576 |
| RPTOR | 10601 | -4826 |
| RRAGA | 11570 | -7681 |
| RRAGB | -3038 | 4672 |
| RRAGC | -10787 | -9790 |
| RRAGD | -5240 | -9110 |
| SEC13 | -9702 | -8646 |
| SEH1L | -9333 | -5653 |
| SESN1 | 7728 | -4176 |
| SESN2 | -6559 | -3744 |
| SH3BP4 | -10917 | -10437 |
| SLC38A9 | 10703 | -7126 |
| SZT2 | 11569 | 6561 |
| TCIRG1 | -9563 | 12083 |
| TRIB3 | -3221 | -5552 |
| UBA52 | -6807 | 11639 |
| WDR24 | -10330 | -7421 |
| WDR59 | -6083 | 10675 |
Stabilization of p53
| metric | value |
|---|---|
| setSize | 53 |
| pMANOVA | 9.56e-11 |
| p.adjustMANOVA | 2.87e-10 |
| s.dist | 0.515 |
| s.KO | -0.425 |
| s.drug | 0.291 |
| p.KO | 8.54e-08 |
| p.drug | 0.000243 |
| Gene | KO | drug |
|---|---|---|
| CHEK2 | -10879 | 12367 |
| SEM1 | -9978 | 13108 |
| PSMA4 | -9907 | 11447 |
| PSMB8 | -9783 | 11153 |
| PSMB7 | -8656 | 12462 |
| PSMB9 | -9810 | 10733 |
| PSME1 | -8654 | 11878 |
| PSMA1 | -9646 | 10578 |
| PSMC2 | -9185 | 11068 |
| PSMD6 | -7577 | 12228 |
| PSMC4 | -7156 | 12714 |
| PSMD14 | -10615 | 8461 |
| UBA52 | -6807 | 11639 |
| PSMB1 | -6139 | 12480 |
| UBC | -10397 | 7017 |
| PSMB6 | -6537 | 10901 |
| PSMA3 | -5668 | 12561 |
| UBB | -5602 | 12024 |
| PSMD13 | -5300 | 12140 |
| PSME2 | -4231 | 12869 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ATM | -300 | -6012 |
| CHEK2 | -10879 | 12367 |
| MDM2 | -3386 | -5606 |
| MDM4 | 3213 | 10020 |
| PHF20 | -6735 | -9542 |
| PSMA1 | -9646 | 10578 |
| PSMA2 | -4002 | -4430 |
| PSMA3 | -5668 | 12561 |
| PSMA4 | -9907 | 11447 |
| PSMA5 | 5538 | 826 |
| PSMA6 | -3328 | 8997 |
| PSMA7 | -10164 | -7607 |
| PSMB1 | -6139 | 12480 |
| PSMB10 | 9537 | 11663 |
| PSMB2 | -3364 | 8976 |
| PSMB3 | 7905 | 13078 |
| PSMB4 | -1370 | 12998 |
| PSMB5 | -6937 | -2970 |
| PSMB6 | -6537 | 10901 |
| PSMB7 | -8656 | 12462 |
| PSMB8 | -9783 | 11153 |
| PSMB9 | -9810 | 10733 |
| PSMC1 | -3547 | -3814 |
| PSMC2 | -9185 | 11068 |
| PSMC3 | -1273 | 12327 |
| PSMC4 | -7156 | 12714 |
| PSMC5 | 7024 | 12041 |
| PSMC6 | -7069 | 697 |
| PSMD1 | -9192 | -10441 |
| PSMD10 | -6869 | 1286 |
| PSMD11 | 7720 | -8518 |
| PSMD12 | 813 | 8775 |
| PSMD13 | -5300 | 12140 |
| PSMD14 | -10615 | 8461 |
| PSMD2 | -6801 | -10378 |
| PSMD3 | -8058 | -4798 |
| PSMD4 | 743 | 11756 |
| PSMD5 | -9642 | -8039 |
| PSMD6 | -7577 | 12228 |
| PSMD7 | -6198 | -6043 |
| PSMD8 | -9103 | -6526 |
| PSMD9 | -7638 | -3346 |
| PSME1 | -8654 | 11878 |
| PSME2 | -4231 | 12869 |
| PSME3 | 11811 | -7813 |
| PSME4 | -10581 | -10843 |
| PSMF1 | -7549 | -4369 |
| RPS27A | 5357 | 6464 |
| SEM1 | -9978 | 13108 |
| TP53 | -3433 | 10144 |
| UBA52 | -6807 | 11639 |
| UBB | -5602 | 12024 |
| UBC | -10397 | 7017 |
Mitochondrial translation
| metric | value |
|---|---|
| setSize | 96 |
| pMANOVA | 6.75e-20 |
| p.adjustMANOVA | 4.05e-19 |
| s.dist | 0.539 |
| s.KO | -0.148 |
| s.drug | 0.518 |
| p.KO | 0.0121 |
| p.drug | 1.55e-18 |
| Gene | KO | drug |
|---|---|---|
| MRPL32 | -10161 | 13017 |
| MRPL2 | -10512 | 12505 |
| MRPS26 | -10158 | 12585 |
| MRPL18 | -8000 | 12866 |
| MRPS34 | -10296 | 9793 |
| GADD45GIP1 | -7299 | 13128 |
| MRPL17 | -7520 | 12273 |
| MRPL34 | -7095 | 13003 |
| MRPL50 | -8242 | 10992 |
| MRPL48 | -7125 | 12684 |
| MRPL41 | -6895 | 12960 |
| MRPL28 | -7301 | 11637 |
| MRPL46 | -9488 | 8908 |
| TUFM | -8420 | 9886 |
| MRPL21 | -6454 | 12815 |
| MRPL14 | -6840 | 11982 |
| MRPL36 | -9849 | 8266 |
| MRPS5 | -9234 | 8657 |
| MRPL39 | -7339 | 10642 |
| MRPS24 | -7478 | 10207 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AURKAIP1 | -133 | 12408 |
| CHCHD1 | 9131 | 12380 |
| DAP3 | -3752 | -565 |
| ERAL1 | 10004 | 6656 |
| GADD45GIP1 | -7299 | 13128 |
| GFM1 | 10740 | -9692 |
| GFM2 | 12241 | -9673 |
| MRPL1 | 7835 | 12136 |
| MRPL10 | 7038 | -3968 |
| MRPL11 | -5116 | 12062 |
| MRPL12 | 3449 | 11754 |
| MRPL13 | 6295 | 1716 |
| MRPL14 | -6840 | 11982 |
| MRPL15 | -7055 | 7319 |
| MRPL16 | 6138 | 12765 |
| MRPL17 | -7520 | 12273 |
| MRPL18 | -8000 | 12866 |
| MRPL19 | -4724 | 8112 |
| MRPL2 | -10512 | 12505 |
| MRPL20 | -3240 | 12687 |
| MRPL21 | -6454 | 12815 |
| MRPL22 | -4827 | 13106 |
| MRPL23 | 7423 | 13081 |
| MRPL24 | -1564 | 13063 |
| MRPL27 | 9389 | 12972 |
| MRPL28 | -7301 | 11637 |
| MRPL3 | -4483 | -1670 |
| MRPL30 | -4144 | -2207 |
| MRPL32 | -10161 | 13017 |
| MRPL33 | 10926 | 3035 |
| MRPL34 | -7095 | 13003 |
| MRPL35 | -2774 | 11796 |
| MRPL36 | -9849 | 8266 |
| MRPL37 | -4668 | -8699 |
| MRPL38 | -373 | 12488 |
| MRPL39 | -7339 | 10642 |
| MRPL4 | -8120 | 1791 |
| MRPL40 | -463 | 12827 |
| MRPL41 | -6895 | 12960 |
| MRPL42 | 2461 | 7413 |
| MRPL43 | 7257 | 10836 |
| MRPL44 | -10349 | -1148 |
| MRPL45 | 6164 | -7914 |
| MRPL46 | -9488 | 8908 |
| MRPL47 | 4811 | 12879 |
| MRPL48 | -7125 | 12684 |
| MRPL49 | -9816 | -6045 |
| MRPL50 | -8242 | 10992 |
| MRPL51 | -2027 | 11363 |
| MRPL52 | 10778 | 12795 |
| MRPL53 | 10106 | 12803 |
| MRPL54 | -4543 | 12461 |
| MRPL55 | 4836 | 12563 |
| MRPL57 | 10690 | 13103 |
| MRPL58 | -3957 | 11786 |
| MRPL9 | -3209 | -1926 |
| MRPS10 | -5700 | -5579 |
| MRPS11 | -8163 | -2495 |
| MRPS12 | -8848 | 3670 |
| MRPS14 | 6215 | 9031 |
| MRPS15 | 812 | 13085 |
| MRPS16 | 8903 | 9672 |
| MRPS17 | 945 | 11882 |
| MRPS18A | -417 | -1247 |
| MRPS18B | -10430 | 2240 |
| MRPS18C | -6186 | 11495 |
| MRPS2 | 1748 | -9247 |
| MRPS21 | 7114 | 13135 |
| MRPS22 | -6687 | 10137 |
| MRPS23 | -2639 | 4213 |
| MRPS24 | -7478 | 10207 |
| MRPS25 | 2659 | 12502 |
| MRPS26 | -10158 | 12585 |
| MRPS27 | 10588 | -8389 |
| MRPS28 | 9220 | 11844 |
| MRPS30 | -10503 | -7448 |
| MRPS31 | -3496 | 12760 |
| MRPS33 | 10443 | 10599 |
| MRPS34 | -10296 | 9793 |
| MRPS35 | -10292 | -5066 |
| MRPS36 | 7958 | 12481 |
| MRPS5 | -9234 | 8657 |
| MRPS6 | -10724 | -4569 |
| MRPS7 | 10093 | 8378 |
| MRPS9 | -5672 | 10173 |
| MRRF | 3892 | 10977 |
| MT-RNR1 | -5225 | 13169 |
| MT-RNR2 | -1383 | 13168 |
| MTFMT | -4746 | 1913 |
| MTIF2 | 7857 | -2173 |
| MTIF3 | -4102 | 9943 |
| MTRF1L | -6090 | -3388 |
| OXA1L | 12157 | 10649 |
| PTCD3 | 4329 | 10448 |
| TSFM | -5098 | 12110 |
| TUFM | -8420 | 9886 |
Mitochondrial protein import
| metric | value |
|---|---|
| setSize | 64 |
| pMANOVA | 2.31e-07 |
| p.adjustMANOVA | 5.55e-07 |
| s.dist | 0.382 |
| s.KO | -0.203 |
| s.drug | 0.324 |
| p.KO | 0.00491 |
| p.drug | 7.42e-06 |
| Gene | KO | drug |
|---|---|---|
| TOMM5 | -10851 | 12880 |
| TIMM44 | -10857 | 12491 |
| PAM16 | -9772 | 13044 |
| BCS1L | -10585 | 11357 |
| TIMM50 | -9302 | 12450 |
| MTX2 | -10384 | 10819 |
| TIMM23 | -8696 | 12559 |
| TOMM6 | -9125 | 11669 |
| COA6 | -8675 | 11732 |
| TIMM17B | -7733 | 11392 |
| TIMM21 | -8728 | 9796 |
| CMC2 | -7214 | 11734 |
| CYC1 | -8796 | 9550 |
| HSCB | -10466 | 7562 |
| TOMM22 | -9961 | 7884 |
| TIMM9 | -7007 | 10249 |
| TOMM40 | -5273 | 12204 |
| TIMM8B | -4807 | 12754 |
| CMC4 | -6934 | 8412 |
| CHCHD5 | -5991 | 9413 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ACO2 | -5040 | -2386 |
| ATP5F1A | 7998 | -9624 |
| ATP5F1B | -8379 | -9015 |
| ATP5MC1 | 10755 | 12985 |
| BCS1L | -10585 | 11357 |
| CHCHD10 | -2946 | 13055 |
| CHCHD2 | -7471 | -405 |
| CHCHD3 | 10648 | -7217 |
| CHCHD4 | -5788 | 6594 |
| CHCHD5 | -5991 | 9413 |
| CHCHD7 | 9814 | 10158 |
| CMC2 | -7214 | 11734 |
| CMC4 | -6934 | 8412 |
| COA4 | -4380 | 9960 |
| COA6 | -8675 | 11732 |
| COQ2 | 2965 | 10768 |
| COX17 | 11802 | 13107 |
| COX19 | 5255 | 5188 |
| CS | -9273 | -10545 |
| CYC1 | -8796 | 9550 |
| DNAJC19 | 9162 | 12416 |
| FXN | 3001 | 6244 |
| GFER | -7333 | -2348 |
| GRPEL1 | -4676 | 2992 |
| GRPEL2 | -6217 | -6186 |
| HSCB | -10466 | 7562 |
| HSPA9 | -6955 | 6549 |
| HSPD1 | -11419 | 4333 |
| IDH3G | 117 | 9128 |
| LDHD | 11695 | -6379 |
| MTX1 | 10553 | 11989 |
| MTX2 | -10384 | 10819 |
| NDUFB8 | 8367 | 13039 |
| PAM16 | -9772 | 13044 |
| PITRM1 | -10074 | -7430 |
| PMPCA | 4049 | 6598 |
| PMPCB | -8267 | -7717 |
| SAMM50 | -10241 | -5933 |
| SLC25A12 | 9436 | 5342 |
| SLC25A13 | 12236 | -4102 |
| SLC25A4 | 1734 | -880 |
| SLC25A6 | 2241 | -1082 |
| TAZ | 8218 | 12600 |
| TIMM10 | -55 | 11810 |
| TIMM10B | 7893 | 4410 |
| TIMM13 | 7282 | 11742 |
| TIMM17A | -5359 | -7898 |
| TIMM17B | -7733 | 11392 |
| TIMM21 | -8728 | 9796 |
| TIMM22 | 569 | 7666 |
| TIMM23 | -8696 | 12559 |
| TIMM44 | -10857 | 12491 |
| TIMM50 | -9302 | 12450 |
| TIMM8A | 2366 | -141 |
| TIMM8B | -4807 | 12754 |
| TIMM9 | -7007 | 10249 |
| TOMM20 | -2506 | -10139 |
| TOMM22 | -9961 | 7884 |
| TOMM40 | -5273 | 12204 |
| TOMM5 | -10851 | 12880 |
| TOMM6 | -9125 | 11669 |
| TOMM7 | 1259 | -5484 |
| TOMM70 | 2104 | -9721 |
| VDAC1 | 10321 | -414 |
Receptor Mediated Mitophagy
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 2.63e-05 |
| p.adjustMANOVA | 4.86e-05 |
| s.dist | 0.819 |
| s.KO | -0.776 |
| s.drug | -0.263 |
| p.KO | 8.3e-06 |
| p.drug | 0.131 |
| Gene | KO | drug |
|---|---|---|
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| SRC | -11388 | -7284 |
| ULK1 | -10494 | -7342 |
| ATG5 | -7565 | -7228 |
| PGAM5 | -10817 | -4475 |
| ATG12 | -4585 | -5690 |
| MAP1LC3B | -9817 | -1760 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ATG12 | -4585 | -5690 |
| ATG5 | -7565 | -7228 |
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| CSNK2B | -9249 | 12011 |
| FUNDC1 | -3096 | 9106 |
| MAP1LC3A | -9431 | 8671 |
| MAP1LC3B | -9817 | -1760 |
| PGAM5 | -10817 | -4475 |
| SRC | -11388 | -7284 |
| ULK1 | -10494 | -7342 |
Mitophagy
| metric | value |
|---|---|
| setSize | 28 |
| pMANOVA | 6.8e-06 |
| p.adjustMANOVA | 1.48e-05 |
| s.dist | 0.535 |
| s.KO | -0.532 |
| s.drug | -0.0476 |
| p.KO | 1.07e-06 |
| p.drug | 0.663 |
| Gene | KO | drug |
|---|---|---|
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| SRC | -11388 | -7284 |
| PINK1 | -9731 | -8514 |
| ULK1 | -10494 | -7342 |
| MFN2 | -8641 | -8214 |
| SQSTM1 | -9459 | -6901 |
| ATG5 | -7565 | -7228 |
| PGAM5 | -10817 | -4475 |
| ATG12 | -4585 | -5690 |
| TOMM20 | -2506 | -10139 |
| MAP1LC3B | -9817 | -1760 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ATG12 | -4585 | -5690 |
| ATG5 | -7565 | -7228 |
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| CSNK2B | -9249 | 12011 |
| FUNDC1 | -3096 | 9106 |
| MAP1LC3A | -9431 | 8671 |
| MAP1LC3B | -9817 | -1760 |
| MFN1 | 9655 | -9134 |
| MFN2 | -8641 | -8214 |
| MTERF3 | -6727 | 11913 |
| PGAM5 | -10817 | -4475 |
| PINK1 | -9731 | -8514 |
| RPS27A | 5357 | 6464 |
| SQSTM1 | -9459 | -6901 |
| SRC | -11388 | -7284 |
| TOMM20 | -2506 | -10139 |
| TOMM22 | -9961 | 7884 |
| TOMM40 | -5273 | 12204 |
| TOMM5 | -10851 | 12880 |
| TOMM6 | -9125 | 11669 |
| TOMM7 | 1259 | -5484 |
| TOMM70 | 2104 | -9721 |
| UBA52 | -6807 | 11639 |
| UBB | -5602 | 12024 |
| UBC | -10397 | 7017 |
| ULK1 | -10494 | -7342 |
| VDAC1 | 10321 | -414 |
Metabolism of amino acids and derivatives
| metric | value |
|---|---|
| setSize | 337 |
| pMANOVA | 1.43e-18 |
| p.adjustMANOVA | 6.85e-18 |
| s.dist | 0.275 |
| s.KO | -0.145 |
| s.drug | 0.234 |
| p.KO | 5.01e-06 |
| p.drug | 1.59e-13 |
| Gene | KO | drug |
|---|---|---|
| ASNS | -10878 | 12349 |
| SEM1 | -9978 | 13108 |
| ECHS1 | -11411 | 11233 |
| RPL22L1 | -10448 | 12221 |
| PDHA1 | -10664 | 11842 |
| RPL9 | -9659 | 12806 |
| RPS17 | -10534 | 11631 |
| RPL34 | -9357 | 12996 |
| RPL12 | -9329 | 12992 |
| RPL26L1 | -9387 | 12770 |
| RPS13 | -9450 | 12652 |
| RPS25 | -9371 | 12690 |
| RPL37A | -9347 | 12675 |
| RPS18 | -9122 | 12984 |
| RPL17 | -8989 | 12909 |
| RPL31 | -8781 | 13131 |
| RPS6 | -9225 | 12405 |
| RPS15A | -8754 | 12989 |
| RPL36 | -8818 | 12868 |
| PSMA4 | -9907 | 11447 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AADAT | 10672 | 7274 |
| AANAT | 12010 | -5836 |
| AASS | -2035 | -7338 |
| ACAD8 | 11347 | 11473 |
| ACADSB | 8386 | 4523 |
| ACAT1 | -10638 | -4238 |
| ADI1 | -3579 | 9094 |
| ADO | 6777 | -9156 |
| AFMID | -4671 | 7924 |
| AGMAT | 994 | 328 |
| AHCY | 1345 | 629 |
| AIMP1 | -9006 | 1838 |
| AIMP2 | 1872 | -2032 |
| ALDH18A1 | -8886 | -10473 |
| ALDH4A1 | 11146 | -3790 |
| ALDH6A1 | -7224 | -8331 |
| ALDH7A1 | 10593 | 11100 |
| ALDH9A1 | -560 | -6258 |
| AMD1 | -9021 | -9915 |
| AMDHD1 | 11155 | 6105 |
| AMT | 6745 | 8913 |
| APIP | -5270 | 9958 |
| ARG1 | 1715 | -1184 |
| ARG2 | -11492 | -11033 |
| ASL | 12501 | 5148 |
| ASNS | -10878 | 12349 |
| ASPA | 5403 | 1602 |
| ASRGL1 | 9236 | 582 |
| ASS1 | 11521 | -1872 |
| AUH | 5719 | 5062 |
| AZIN1 | -8879 | -10550 |
| AZIN2 | 3795 | 3688 |
| BCAT1 | -7644 | -9371 |
| BCAT2 | -6548 | 8118 |
| BCKDHA | 8458 | -10040 |
| BCKDHB | 10575 | 160 |
| BCKDK | -4165 | -6907 |
| BHMT | -547 | 5797 |
| BHMT2 | 12451 | 10224 |
| CARNMT1 | -7382 | -7203 |
| CARNS1 | 6990 | 326 |
| CBS | 10907 | 11159 |
| CBSL | -586 | 5098 |
| CGA | 4785 | 2191 |
| CHDH | 12135 | 8784 |
| CKB | 11133 | 11188 |
| CKM | -2654 | 386 |
| CKMT1A | 10958 | 11903 |
| CKMT2 | 4895 | -1910 |
| CPS1 | -10630 | 6101 |
| CRYM | -7062 | 2482 |
| CSAD | -3233 | 12728 |
| CTH | -3063 | -3718 |
| DARS1 | -10008 | 4483 |
| DBH | 9900 | -1549 |
| DBT | -3782 | -8648 |
| DCT | -3537 | 2001 |
| DDO | 2059 | -137 |
| DHTKD1 | -1810 | -8372 |
| DIO2 | -8254 | 8806 |
| DLAT | -8123 | -7745 |
| DLD | -9253 | -8294 |
| DLST | -8194 | -10831 |
| DMGDH | 9315 | 3116 |
| DUOX1 | 6936 | -3160 |
| DUOX2 | 1184 | -269 |
| ECHS1 | -11411 | 11233 |
| EEF1E1 | -10204 | 1084 |
| EEFSEC | 11184 | -3492 |
| ENOPH1 | -10785 | 1785 |
| EPRS1 | 1368 | -10895 |
| ETHE1 | -10431 | -6139 |
| FAH | -6674 | 8819 |
| FAU | -8610 | 13102 |
| FOLH1 | -7523 | 445 |
| FTCD | 6855 | 10549 |
| GADL1 | -795 | -1006 |
| GAMT | 11210 | 12230 |
| GATM | 11947 | -7095 |
| GCAT | -10028 | 11163 |
| GCDH | 6035 | 9903 |
| GCSH | -6761 | 9913 |
| GLDC | 4017 | -7420 |
| GLS | -9356 | -8809 |
| GLS2 | 9366 | 2679 |
| GLUD1 | -9514 | -10318 |
| GLUD2 | -5197 | -4510 |
| GLUL | 12531 | -9935 |
| GNMT | -1375 | 5139 |
| GOT1 | -251 | 7784 |
| GOT2 | 11173 | 841 |
| GPT | 8865 | 9142 |
| GPT2 | 8365 | 7519 |
| GRHPR | -6215 | 8320 |
| GSR | -11433 | -4996 |
| GSTZ1 | 10777 | 8707 |
| HAAO | 8688 | 9133 |
| HAL | -3269 | 4475 |
| HIBADH | 2089 | 8513 |
| HIBCH | -2666 | 969 |
| HNMT | -1649 | 3699 |
| HOGA1 | 1298 | 5341 |
| HPD | 1912 | 5180 |
| HSD17B10 | 2620 | 11931 |
| HYKK | -4392 | 9854 |
| IARS1 | -2182 | -9570 |
| IDO2 | 4265 | 2865 |
| IL4I1 | -11099 | -4396 |
| INMT | 9444 | -4952 |
| IVD | 12121 | -4420 |
| IYD | -351 | 5080 |
| KARS1 | -10243 | 9778 |
| KMO | 7390 | 6829 |
| KYAT1 | -5720 | 2274 |
| KYAT3 | 10416 | -9152 |
| KYNU | -2499 | 6757 |
| LARS1 | -7999 | -5859 |
| LIAS | -9105 | 5143 |
| LIPT1 | -8180 | 2538 |
| LIPT2 | -2271 | 5033 |
| MARS1 | -1476 | 10979 |
| MAT1A | -6091 | 2828 |
| MCCC1 | 12225 | -6790 |
| MCCC2 | 8284 | -1797 |
| MPST | -4372 | 12019 |
| MRI1 | -8262 | 9899 |
| MTAP | 5134 | 6545 |
| MTR | 92 | -9742 |
| MTRR | -8284 | -8513 |
| NAALAD2 | 7668 | 8036 |
| NAGS | 11887 | -8985 |
| NAT8L | -4195 | -9350 |
| NDUFAB1 | -10558 | 8746 |
| NMRAL1 | -6580 | 12010 |
| NNMT | 12760 | 12864 |
| NQO1 | 12497 | 12065 |
| OAT | 10923 | -3605 |
| OAZ1 | -5995 | 8537 |
| OAZ2 | 12305 | -4736 |
| OAZ3 | -4681 | -2934 |
| OCA2 | 11312 | -5329 |
| ODC1 | -11548 | -8715 |
| OGDH | -5384 | -7828 |
| PAOX | 10273 | -5165 |
| PAPSS1 | -10307 | -3927 |
| PAPSS2 | 6847 | -10771 |
| PCBD1 | 10442 | 9074 |
| PDHA1 | -10664 | 11842 |
| PDHB | -3368 | 12152 |
| PDHX | -9039 | -4928 |
| PHGDH | 10381 | 12550 |
| PHYKPL | 12650 | 4336 |
| PIPOX | 3326 | -2663 |
| PNMT | 6175 | 5951 |
| PPM1K | -9252 | -7689 |
| PRODH | 4648 | 8935 |
| PSAT1 | -8575 | 11575 |
| PSMA1 | -9646 | 10578 |
| PSMA2 | -4002 | -4430 |
| PSMA3 | -5668 | 12561 |
| PSMA4 | -9907 | 11447 |
| PSMA5 | 5538 | 826 |
| PSMA6 | -3328 | 8997 |
| PSMA7 | -10164 | -7607 |
| PSMB1 | -6139 | 12480 |
| PSMB10 | 9537 | 11663 |
| PSMB2 | -3364 | 8976 |
| PSMB3 | 7905 | 13078 |
| PSMB4 | -1370 | 12998 |
| PSMB5 | -6937 | -2970 |
| PSMB6 | -6537 | 10901 |
| PSMB7 | -8656 | 12462 |
| PSMB8 | -9783 | 11153 |
| PSMB9 | -9810 | 10733 |
| PSMC1 | -3547 | -3814 |
| PSMC2 | -9185 | 11068 |
| PSMC3 | -1273 | 12327 |
| PSMC4 | -7156 | 12714 |
| PSMC5 | 7024 | 12041 |
| PSMC6 | -7069 | 697 |
| PSMD1 | -9192 | -10441 |
| PSMD10 | -6869 | 1286 |
| PSMD11 | 7720 | -8518 |
| PSMD12 | 813 | 8775 |
| PSMD13 | -5300 | 12140 |
| PSMD14 | -10615 | 8461 |
| PSMD2 | -6801 | -10378 |
| PSMD3 | -8058 | -4798 |
| PSMD4 | 743 | 11756 |
| PSMD5 | -9642 | -8039 |
| PSMD6 | -7577 | 12228 |
| PSMD7 | -6198 | -6043 |
| PSMD8 | -9103 | -6526 |
| PSMD9 | -7638 | -3346 |
| PSME1 | -8654 | 11878 |
| PSME2 | -4231 | 12869 |
| PSME3 | 11811 | -7813 |
| PSME4 | -10581 | -10843 |
| PSMF1 | -7549 | -4369 |
| PSPH | 11422 | 7040 |
| PSTK | 5756 | 9314 |
| PXMP2 | 10630 | 4583 |
| PYCR1 | -4927 | -11012 |
| PYCR2 | 9765 | 12269 |
| QARS1 | 10134 | -6688 |
| QDPR | 11360 | -6120 |
| RARS1 | -9720 | -7252 |
| RIDA | -72 | 11337 |
| RIMKLA | 12748 | -8994 |
| RIMKLB | -8314 | 347 |
| RPL10 | -3821 | 1597 |
| RPL10A | -9707 | -8212 |
| RPL11 | -8529 | 12382 |
| RPL12 | -9329 | 12992 |
| RPL13 | -3469 | 12598 |
| RPL13A | -6854 | 6955 |
| RPL14 | -6386 | 13137 |
| RPL15 | -786 | 12153 |
| RPL17 | -8989 | 12909 |
| RPL18 | -6672 | 12800 |
| RPL18A | -6976 | 11926 |
| RPL19 | 3924 | 12911 |
| RPL21 | -6322 | 5141 |
| RPL22 | -5554 | 9520 |
| RPL22L1 | -10448 | 12221 |
| RPL23 | 5769 | 12922 |
| RPL23A | 11361 | -5257 |
| RPL24 | -4591 | 12995 |
| RPL26 | -8797 | 12658 |
| RPL26L1 | -9387 | 12770 |
| RPL27 | 6735 | 11625 |
| RPL27A | -7818 | 13051 |
| RPL28 | -5809 | 12962 |
| RPL29 | -4515 | 12915 |
| RPL3 | -6827 | -4535 |
| RPL30 | -3907 | 11096 |
| RPL31 | -8781 | 13131 |
| RPL32 | -5028 | 12983 |
| RPL34 | -9357 | 12996 |
| RPL35 | -8027 | 13097 |
| RPL35A | -1449 | 12789 |
| RPL36 | -8818 | 12868 |
| RPL36A | -4480 | 13009 |
| RPL36AL | -8216 | 12702 |
| RPL37 | -4624 | 13134 |
| RPL37A | -9347 | 12675 |
| RPL38 | 1558 | 13140 |
| RPL39 | -6168 | 11962 |
| RPL39L | -6608 | -6269 |
| RPL3L | -510 | 7904 |
| RPL4 | 11351 | 12558 |
| RPL41 | -4616 | -6074 |
| RPL5 | 4679 | 12075 |
| RPL6 | -6903 | 12730 |
| RPL7 | -3327 | -8789 |
| RPL7A | -6163 | 11708 |
| RPL8 | -7572 | 10323 |
| RPL9 | -9659 | 12806 |
| RPLP0 | -1504 | -7331 |
| RPLP1 | 9026 | 12731 |
| RPLP2 | -8225 | 12999 |
| RPS10 | -8384 | 10665 |
| RPS11 | -7725 | 12935 |
| RPS12 | -7872 | 11600 |
| RPS13 | -9450 | 12652 |
| RPS14 | -1180 | 12428 |
| RPS15 | -7430 | 12908 |
| RPS15A | -8754 | 12989 |
| RPS16 | -3844 | 12941 |
| RPS17 | -10534 | 11631 |
| RPS18 | -9122 | 12984 |
| RPS19 | -7633 | 12888 |
| RPS2 | -10222 | 8916 |
| RPS20 | -4961 | 13095 |
| RPS21 | -3001 | 13022 |
| RPS23 | 6940 | 11907 |
| RPS24 | 2369 | 13034 |
| RPS25 | -9371 | 12690 |
| RPS26 | -2615 | 13114 |
| RPS27 | 651 | 11270 |
| RPS27A | 5357 | 6464 |
| RPS27L | 7330 | 12750 |
| RPS28 | 2716 | 12485 |
| RPS29 | -652 | 9078 |
| RPS3 | -7756 | 12135 |
| RPS3A | -9170 | 5257 |
| RPS4X | -8542 | 12239 |
| RPS5 | -6283 | -7965 |
| RPS6 | -9225 | 12405 |
| RPS7 | 5142 | 12976 |
| RPS8 | -5812 | 12745 |
| RPS9 | -8815 | 10189 |
| RPSA | 292 | 11576 |
| SARDH | 11797 | -2513 |
| SARS1 | 10748 | -9421 |
| SAT1 | -11516 | 8580 |
| SCLY | -9481 | 10671 |
| SDS | 3809 | 3212 |
| SDSL | 11650 | 4044 |
| SECISBP2 | 11207 | -6517 |
| SEM1 | -9978 | 13108 |
| SEPHS2 | 8103 | -351 |
| SEPSECS | -6443 | -5096 |
| SERINC1 | -8559 | -10927 |
| SERINC2 | 12901 | -4299 |
| SERINC3 | -9690 | -10718 |
| SERINC5 | -10855 | -10123 |
| SHMT1 | 10041 | 12191 |
| SLC25A10 | 10535 | 10876 |
| SLC25A12 | 9436 | 5342 |
| SLC25A13 | 12236 | -4102 |
| SLC25A15 | -8051 | -6219 |
| SLC25A21 | 1939 | -353 |
| SLC25A44 | 8439 | -6942 |
| SLC36A4 | -1600 | -8668 |
| SLC3A2 | -9319 | -3436 |
| SLC44A1 | 3030 | -8195 |
| SLC5A5 | 5760 | 4246 |
| SLC6A11 | 10785 | -3525 |
| SLC6A12 | -4244 | 1206 |
| SLC6A8 | 12417 | -9058 |
| SLC7A5 | -9076 | -4839 |
| SMOX | -3994 | -11021 |
| SMS | -11167 | -1993 |
| SRM | -7150 | 11902 |
| SRR | -6159 | 7210 |
| SUOX | 11819 | 9645 |
| TAT | 4699 | 448 |
| TDO2 | 8914 | 5887 |
| TMLHE | 10560 | -7649 |
| TPH1 | 3976 | 9198 |
| TPH2 | -308 | 7806 |
| TPO | 4072 | 7357 |
| TST | 9957 | 10661 |
| TXN2 | -8694 | 3274 |
| TXNRD1 | -10964 | -9955 |
| UBA52 | -6807 | 11639 |
Diseases of carbohydrate metabolism
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 0.00899 |
| p.adjustMANOVA | 0.00938 |
| s.dist | 0.32 |
| s.KO | 0.319 |
| s.drug | -0.0263 |
| p.KO | 0.00249 |
| p.drug | 0.803 |
| Gene | KO | drug |
|---|---|---|
| GBE1 | 12790 | -10994 |
| GNS | 11099 | -11125 |
| GLB1 | 10162 | -9240 |
| GYG1 | 10629 | -8829 |
| ARSB | 12086 | -7494 |
| IDS | 8178 | -10132 |
| GAA | 12540 | -6361 |
| GALNS | 11751 | -6370 |
| NAGLU | 12163 | -5299 |
| PPP1R3C | 10573 | -5635 |
| HGSNAT | 6442 | -3959 |
| GYG2 | 10117 | -1505 |
| KHK | 6482 | -1164 |
| ALDOB | 2760 | -1433 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ALDOB | 2760 | -1433 |
| ARSB | 12086 | -7494 |
| DCXR | -6370 | 12401 |
| EPM2A | -7152 | 2522 |
| G6PC3 | 11270 | 11945 |
| GAA | 12540 | -6361 |
| GALNS | 11751 | -6370 |
| GBE1 | 12790 | -10994 |
| GLB1 | 10162 | -9240 |
| GNS | 11099 | -11125 |
| GUSB | 9430 | 8910 |
| GYG1 | 10629 | -8829 |
| GYG2 | 10117 | -1505 |
| GYS1 | -8713 | -8373 |
| HGSNAT | 6442 | -3959 |
| HYAL1 | 4794 | 556 |
| IDS | 8178 | -10132 |
| IDUA | 11538 | 11620 |
| KHK | 6482 | -1164 |
| NAGLU | 12163 | -5299 |
| NHLRC1 | 9210 | 6494 |
| PPP1R3C | 10573 | -5635 |
| RPIA | -1807 | -4134 |
| RPS27A | 5357 | 6464 |
| SGSH | 11466 | 8231 |
| SLC37A4 | -6962 | 9471 |
| TALDO1 | -9895 | 11544 |
| UBA52 | -6807 | 11639 |
| UBB | -5602 | 12024 |
| UBC | -10397 | 7017 |
PTEN Regulation
| metric | value |
|---|---|
| setSize | 140 |
| pMANOVA | 1.48e-08 |
| p.adjustMANOVA | 3.96e-08 |
| s.dist | 0.302 |
| s.KO | -0.283 |
| s.drug | -0.105 |
| p.KO | 7.59e-09 |
| p.drug | 0.0312 |
| Gene | KO | drug |
|---|---|---|
| AGO2 | -10824 | -10899 |
| PSME4 | -10581 | -10843 |
| CSNK2A1 | -10604 | -10586 |
| TNKS | -11005 | -10107 |
| RCOR1 | -10367 | -10614 |
| USP7 | -11306 | -9522 |
| REST | -10029 | -10671 |
| RRAGC | -10787 | -9790 |
| CSNK2A2 | -9949 | -10332 |
| GATAD2B | -9311 | -10855 |
| MAPK1 | -9173 | -10906 |
| PSMD1 | -9192 | -10441 |
| KDM1A | -10032 | -9331 |
| TNRC6B | -10673 | -8745 |
| MAPK3 | -9742 | -9271 |
| GATAD2A | -11048 | -7912 |
| VAPA | -10099 | -8584 |
| HDAC5 | -9547 | -9053 |
| AGO3 | -9916 | -8382 |
| ATF2 | -8942 | -9289 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AGO1 | -7681 | -6719 |
| AGO2 | -10824 | -10899 |
| AGO3 | -9916 | -8382 |
| AGO4 | 8566 | -7725 |
| AKT1 | -1733 | -1215 |
| AKT2 | 9732 | 3410 |
| AKT3 | 6626 | -10834 |
| ATF2 | -8942 | -9289 |
| ATN1 | -5130 | -6152 |
| BMI1 | -6365 | -9563 |
| CBX2 | 8151 | -5128 |
| CBX4 | 5239 | -5196 |
| CBX6 | -5993 | -5822 |
| CBX8 | 8308 | 10487 |
| CHD3 | -5284 | -8323 |
| CHD4 | -4510 | -10191 |
| CNOT6L | -8358 | -9361 |
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| CSNK2B | -9249 | 12011 |
| EED | -8207 | -1581 |
| EGR1 | -11412 | 4407 |
| EZH2 | 11841 | 12709 |
| FRK | 6214 | -2830 |
| GATAD2A | -11048 | -7912 |
| GATAD2B | -9311 | -10855 |
| HDAC1 | -5601 | 11449 |
| HDAC2 | -9786 | -6704 |
| HDAC3 | 10500 | -7476 |
| HDAC5 | -9547 | -9053 |
| HDAC7 | 7031 | -8451 |
| JUN | 12224 | 6311 |
| KDM1A | -10032 | -9331 |
| LAMTOR1 | -5671 | -7722 |
| LAMTOR2 | 5420 | 10180 |
| LAMTOR3 | -2587 | 6218 |
| LAMTOR4 | -8066 | 10839 |
| LAMTOR5 | 6245 | 11081 |
| MAF1 | -7678 | -3960 |
| MAPK1 | -9173 | -10906 |
| MAPK3 | -9742 | -9271 |
| MBD3 | -6720 | 12289 |
| MECOM | 11240 | -6980 |
| MKRN1 | 12553 | -9976 |
| MLST8 | -10314 | -4897 |
| MOV10 | 6666 | 10563 |
| MTA1 | -5679 | 10842 |
| MTA2 | -8669 | 5527 |
| MTA3 | 654 | 10406 |
| MTOR | 8963 | -5908 |
| NEDD4 | 11639 | -9004 |
| NR2E1 | -482 | -911 |
| OTUD3 | -10780 | -6953 |
| PHC1 | 8769 | 4837 |
| PHC2 | 11301 | -9451 |
| PHC3 | -7418 | -9924 |
| PML | -5371 | -6979 |
| PPARG | 12799 | 9364 |
| PREX2 | 10194 | -4586 |
| PSMA1 | -9646 | 10578 |
| PSMA2 | -4002 | -4430 |
| PSMA3 | -5668 | 12561 |
| PSMA4 | -9907 | 11447 |
| PSMA5 | 5538 | 826 |
| PSMA6 | -3328 | 8997 |
| PSMA7 | -10164 | -7607 |
| PSMB1 | -6139 | 12480 |
| PSMB10 | 9537 | 11663 |
| PSMB2 | -3364 | 8976 |
| PSMB3 | 7905 | 13078 |
| PSMB4 | -1370 | 12998 |
| PSMB5 | -6937 | -2970 |
| PSMB6 | -6537 | 10901 |
| PSMB7 | -8656 | 12462 |
| PSMB8 | -9783 | 11153 |
| PSMB9 | -9810 | 10733 |
| PSMC1 | -3547 | -3814 |
| PSMC2 | -9185 | 11068 |
| PSMC3 | -1273 | 12327 |
| PSMC4 | -7156 | 12714 |
| PSMC5 | 7024 | 12041 |
| PSMC6 | -7069 | 697 |
| PSMD1 | -9192 | -10441 |
| PSMD10 | -6869 | 1286 |
| PSMD11 | 7720 | -8518 |
| PSMD12 | 813 | 8775 |
| PSMD13 | -5300 | 12140 |
| PSMD14 | -10615 | 8461 |
| PSMD2 | -6801 | -10378 |
| PSMD3 | -8058 | -4798 |
| PSMD4 | 743 | 11756 |
| PSMD5 | -9642 | -8039 |
| PSMD6 | -7577 | 12228 |
| PSMD7 | -6198 | -6043 |
| PSMD8 | -9103 | -6526 |
| PSMD9 | -7638 | -3346 |
| PSME1 | -8654 | 11878 |
| PSME2 | -4231 | 12869 |
| PSME3 | 11811 | -7813 |
| PSME4 | -10581 | -10843 |
| PSMF1 | -7549 | -4369 |
| PTEN | -6933 | -8533 |
| PTENP1 | -7139 | -534 |
| RBBP4 | -5569 | -4482 |
| RBBP7 | -7044 | -6256 |
| RCOR1 | -10367 | -10614 |
| REST | -10029 | -10671 |
| RHEB | 11691 | 4362 |
| RING1 | -3031 | 11489 |
| RNF146 | 2285 | 1860 |
| RNF2 | -7038 | -9730 |
| RPS27A | 5357 | 6464 |
| RPTOR | 10601 | -4826 |
| RRAGA | 11570 | -7681 |
| RRAGB | -3038 | 4672 |
| RRAGC | -10787 | -9790 |
| RRAGD | -5240 | -9110 |
| SALL4 | -2003 | 12606 |
| SCMH1 | 7811 | 6193 |
| SEM1 | -9978 | 13108 |
| SLC38A9 | 10703 | -7126 |
| SNAI1 | -521 | -4976 |
| SNAI2 | -6452 | -6811 |
| STUB1 | -10050 | 1054 |
| SUZ12 | -10605 | 9924 |
| TNKS | -11005 | -10107 |
| TNKS2 | 6087 | -11079 |
| TNRC6A | 2904 | -5402 |
| TNRC6B | -10673 | -8745 |
| TNRC6C | -5035 | -5659 |
| TP53 | -3433 | 10144 |
| TRIM27 | -8330 | -9054 |
| UBA52 | -6807 | 11639 |
| UBB | -5602 | 12024 |
| UBC | -10397 | 7017 |
| USP13 | 4677 | -8544 |
| USP7 | -11306 | -9522 |
| VAPA | -10099 | -8584 |
| WWP2 | 10930 | -5526 |
| XIAP | -5888 | -8812 |
Gene Silencing by RNA
| metric | value |
|---|---|
| setSize | 95 |
| pMANOVA | 0.000197 |
| p.adjustMANOVA | 0.00028 |
| s.dist | 0.25 |
| s.KO | -0.241 |
| s.drug | -0.0668 |
| p.KO | 4.88e-05 |
| p.drug | 0.26 |
| Gene | KO | drug |
|---|---|---|
| POLR2A | -11346 | -10737 |
| AGO2 | -10824 | -10899 |
| NUP98 | -10847 | -10135 |
| NUP160 | -10172 | -9854 |
| TNRC6B | -10673 | -8745 |
| POLR2B | -9710 | -9575 |
| XPO5 | -11181 | -7902 |
| NUP54 | -10563 | -8348 |
| NUP153 | -8447 | -10433 |
| POM121 | -8878 | -9749 |
| POM121C | -9406 | -9089 |
| SEC13 | -9702 | -8646 |
| AGO3 | -9916 | -8382 |
| PRKRA | -11124 | -6874 |
| NUP58 | -7370 | -10308 |
| RANBP2 | -5941 | -10334 |
| H2BC12 | -11325 | -5127 |
| PIWIL4 | -8830 | -6551 |
| NUP188 | -11151 | -5029 |
| H2AC6 | -9780 | -5570 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AAAS | -4744.0 | 12385.0 |
| AGO1 | -7681.0 | -6719.0 |
| AGO2 | -10824.0 | -10899.0 |
| AGO3 | -9916.0 | -8382.0 |
| AGO4 | 8566.0 | -7725.0 |
| ANG | -8308.0 | 6399.0 |
| ASZ1 | -3091.0 | 2588.0 |
| BCDIN3D | 6633.0 | -609.0 |
| DDX4 | -147.0 | 1685.0 |
| DGCR8 | 5463.0 | 11973.0 |
| DICER1 | 9558.0 | -10089.0 |
| DROSHA | 8522.0 | -840.0 |
| ELAC2 | -9745.0 | -1209.0 |
| FKBP6 | -3045.0 | 4019.0 |
| H2AB1 | 1660.0 | 3002.0 |
| H2AC18 | -423.0 | 1717.0 |
| H2AC20 | 4883.0 | 12475.0 |
| H2AC6 | -9780.0 | -5570.0 |
| H2AC7 | -4712.0 | 3732.0 |
| H2AJ | 10209.0 | 12881.0 |
| H2AZ1 | -5624.0 | 10622.0 |
| H2AZ2 | 11794.0 | 9855.0 |
| H2BC11 | -9400.0 | 4223.0 |
| H2BC12 | -11325.0 | -5127.0 |
| H2BC13 | -3431.0 | 4126.0 |
| H2BC15 | -10438.0 | -2637.0 |
| H2BC17 | -4337.0 | 6295.0 |
| H2BC21 | -9686.0 | 5246.0 |
| H2BC4 | -8905.0 | 4090.0 |
| H2BC5 | -10114.0 | 11266.0 |
| H2BC9 | 4874.0 | 7802.0 |
| H2BU1 | 7724.0 | 6707.0 |
| H3-3A | 10967.0 | 12329.0 |
| H3C1 | -1179.0 | 2773.0 |
| H3C15 | 2532.5 | 7678.5 |
| HENMT1 | 12193.0 | 9214.0 |
| HSP90AA1 | 11397.0 | -7534.0 |
| IPO8 | 9161.0 | -9736.0 |
| MAEL | 1932.0 | -607.0 |
| MYBL1 | 8942.0 | 5892.0 |
| NDC1 | -5800.0 | -9199.0 |
| NUP107 | 10317.0 | 11210.0 |
| NUP133 | 6251.0 | -8590.0 |
| NUP153 | -8447.0 | -10433.0 |
| NUP155 | 1534.0 | -10720.0 |
| NUP160 | -10172.0 | -9854.0 |
| NUP188 | -11151.0 | -5029.0 |
| NUP205 | 12369.0 | -7848.0 |
| NUP210 | 12856.0 | -5260.0 |
| NUP214 | -6331.0 | -6303.0 |
| NUP35 | -10251.0 | 8114.0 |
| NUP37 | 3092.0 | 10117.0 |
| NUP42 | 8137.0 | 9137.0 |
| NUP43 | -7490.0 | 9638.0 |
| NUP50 | -10234.0 | -3947.0 |
| NUP54 | -10563.0 | -8348.0 |
| NUP58 | -7370.0 | -10308.0 |
| NUP62 | -5900.0 | -6034.0 |
| NUP85 | 7849.0 | 10502.0 |
| NUP88 | -10968.0 | 2131.0 |
| NUP93 | -6918.0 | -6255.0 |
| NUP98 | -10847.0 | -10135.0 |
| PIWIL2 | -8415.0 | 4782.0 |
| PIWIL4 | -8830.0 | -6551.0 |
| PLD6 | -11240.0 | -2847.0 |
| POLR2A | -11346.0 | -10737.0 |
| POLR2B | -9710.0 | -9575.0 |
| POLR2C | -9451.0 | -4938.0 |
| POLR2D | -9238.0 | 4530.0 |
| POLR2E | -4690.0 | -3689.0 |
| POLR2F | -8900.0 | 12621.0 |
| POLR2G | -5631.0 | 9765.0 |
| POLR2H | 7259.0 | 12667.0 |
| POLR2I | -5731.0 | 12659.0 |
| POLR2J | -6932.0 | 12928.0 |
| POLR2K | 8115.0 | 12316.0 |
| POLR2L | 12166.0 | 11532.0 |
| POM121 | -8878.0 | -9749.0 |
| POM121C | -9406.0 | -9089.0 |
| PRKRA | -11124.0 | -6874.0 |
| RAE1 | -7356.0 | -5016.0 |
| RAN | -5185.0 | 5548.0 |
| RANBP2 | -5941.0 | -10334.0 |
| SEC13 | -9702.0 | -8646.0 |
| SEH1L | -9333.0 | -5653.0 |
| TARBP2 | -646.0 | 10233.0 |
| TDRD6 | 1935.0 | 2808.0 |
| TDRKH | 12059.0 | -9074.0 |
| TNRC6A | 2904.0 | -5402.0 |
| TNRC6B | -10673.0 | -8745.0 |
| TNRC6C | -5035.0 | -5659.0 |
| TPR | 8761.0 | -5834.0 |
| TSN | -10134.0 | -4754.0 |
| TSNAX | 6262.0 | -4484.0 |
| XPO5 | -11181.0 | -7902.0 |
Nucleotide biosynthesis
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00367 |
| p.adjustMANOVA | 0.0042 |
| s.dist | 0.581 |
| s.KO | -0.482 |
| s.drug | -0.324 |
| p.KO | 0.00383 |
| p.drug | 0.0517 |
| Gene | KO | drug |
|---|---|---|
| GART | -10887 | -9545 |
| PPAT | -10102 | -9936 |
| IMPDH2 | -9060 | -9748 |
| CAD | -7984 | -10810 |
| PAICS | -8896 | -7785 |
| IMPDH1 | -8676 | -5498 |
| GMPS | -4389 | -7492 |
| UMPS | -2365 | -3118 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ADSL | -7101 | 5099 |
| ATIC | -10939 | 1689 |
| CAD | -7984 | -10810 |
| DHODH | 7360 | 10538 |
| GART | -10887 | -9545 |
| GMPS | -4389 | -7492 |
| IMPDH1 | -8676 | -5498 |
| IMPDH2 | -9060 | -9748 |
| PAICS | -8896 | -7785 |
| PFAS | 10370 | 10384 |
| PPAT | -10102 | -9936 |
| UMPS | -2365 | -3118 |
Oxidative Stress Induced Senescence
| metric | value |
|---|---|
| setSize | 82 |
| pMANOVA | 0.0285 |
| p.adjustMANOVA | 0.0285 |
| s.dist | 0.172 |
| s.KO | -0.17 |
| s.drug | -0.0223 |
| p.KO | 0.00768 |
| p.drug | 0.726 |
| Gene | KO | drug |
|---|---|---|
| CDK6 | -10019 | -10704 |
| MAPK1 | -9173 | -10906 |
| TNRC6B | -10673 | -8745 |
| MAP2K4 | -10073 | -9026 |
| MAPK3 | -9742 | -9271 |
| MAPKAPK3 | -9412 | -9424 |
| AGO3 | -9916 | -8382 |
| MINK1 | -9952 | -8148 |
| MAP2K7 | -9331 | -8434 |
| PHC3 | -7418 | -9924 |
| MAPK14 | -9586 | -7538 |
| RNF2 | -7038 | -9730 |
| BMI1 | -6365 | -9563 |
| H2BC12 | -11325 | -5127 |
| MAP3K5 | -6530 | -8473 |
| H2AC6 | -9780 | -5570 |
| AGO1 | -7681 | -6719 |
| RBBP7 | -7044 | -6256 |
| CDKN2C | -10414 | -3360 |
| CBX6 | -5993 | -5822 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AGO1 | -7681.0 | -6719.0 |
| AGO3 | -9916.0 | -8382.0 |
| AGO4 | 8566.0 | -7725.0 |
| BMI1 | -6365.0 | -9563.0 |
| CBX2 | 8151.0 | -5128.0 |
| CBX4 | 5239.0 | -5196.0 |
| CBX6 | -5993.0 | -5822.0 |
| CBX8 | 8308.0 | 10487.0 |
| CDK4 | 8549.0 | 5365.0 |
| CDK6 | -10019.0 | -10704.0 |
| CDKN2C | -10414.0 | -3360.0 |
| CDKN2D | -9132.0 | -3424.0 |
| E2F1 | 12280.0 | 12326.0 |
| E2F2 | 11932.0 | 10469.0 |
| E2F3 | -1962.0 | -2490.0 |
| EED | -8207.0 | -1581.0 |
| EZH2 | 11841.0 | 12709.0 |
| FOS | -10951.0 | 11741.0 |
| H2AB1 | 1660.0 | 3002.0 |
| H2AC18 | -423.0 | 1717.0 |
| H2AC20 | 4883.0 | 12475.0 |
| H2AC6 | -9780.0 | -5570.0 |
| H2AC7 | -4712.0 | 3732.0 |
| H2AJ | 10209.0 | 12881.0 |
| H2AZ1 | -5624.0 | 10622.0 |
| H2AZ2 | 11794.0 | 9855.0 |
| H2BC11 | -9400.0 | 4223.0 |
| H2BC12 | -11325.0 | -5127.0 |
| H2BC13 | -3431.0 | 4126.0 |
| H2BC15 | -10438.0 | -2637.0 |
| H2BC17 | -4337.0 | 6295.0 |
| H2BC21 | -9686.0 | 5246.0 |
| H2BC4 | -8905.0 | 4090.0 |
| H2BC5 | -10114.0 | 11266.0 |
| H2BC9 | 4874.0 | 7802.0 |
| H2BU1 | 7724.0 | 6707.0 |
| H3-3A | 10967.0 | 12329.0 |
| H3C1 | -1179.0 | 2773.0 |
| H3C15 | 2532.5 | 7678.5 |
| JUN | 12224.0 | 6311.0 |
| KDM6B | -2868.0 | -8061.0 |
| MAP2K3 | -8485.0 | 711.0 |
| MAP2K4 | -10073.0 | -9026.0 |
| MAP2K6 | 9842.0 | 8872.0 |
| MAP2K7 | -9331.0 | -8434.0 |
| MAP3K5 | -6530.0 | -8473.0 |
| MAP4K4 | -3184.0 | -8766.0 |
| MAPK1 | -9173.0 | -10906.0 |
| MAPK10 | 10395.0 | 5960.0 |
| MAPK11 | 10678.0 | 4248.0 |
| MAPK14 | -9586.0 | -7538.0 |
| MAPK3 | -9742.0 | -9271.0 |
| MAPK8 | -3223.0 | -5847.0 |
| MAPK9 | -1848.0 | -6014.0 |
| MAPKAPK2 | -3317.0 | -7911.0 |
| MAPKAPK3 | -9412.0 | -9424.0 |
| MAPKAPK5 | -8152.0 | -3964.0 |
| MDM2 | -3386.0 | -5606.0 |
| MDM4 | 3213.0 | 10020.0 |
| MINK1 | -9952.0 | -8148.0 |
| MOV10 | 6666.0 | 10563.0 |
| PHC1 | 8769.0 | 4837.0 |
| PHC2 | 11301.0 | -9451.0 |
| PHC3 | -7418.0 | -9924.0 |
| RBBP4 | -5569.0 | -4482.0 |
| RBBP7 | -7044.0 | -6256.0 |
| RING1 | -3031.0 | 11489.0 |
| RNF2 | -7038.0 | -9730.0 |
| RPS27A | 5357.0 | 6464.0 |
| SCMH1 | 7811.0 | 6193.0 |
| SUZ12 | -10605.0 | 9924.0 |
| TFDP1 | 9813.0 | -4284.0 |
| TFDP2 | 12211.0 | 902.0 |
| TNIK | 12604.0 | -10048.0 |
| TNRC6A | 2904.0 | -5402.0 |
| TNRC6B | -10673.0 | -8745.0 |
| TNRC6C | -5035.0 | -5659.0 |
| TP53 | -3433.0 | 10144.0 |
| TXN | -7456.0 | 12957.0 |
| UBA52 | -6807.0 | 11639.0 |
| UBB | -5602.0 | 12024.0 |
| UBC | -10397.0 | 7017.0 |
Mitochondrial biogenesis
| metric | value |
|---|---|
| setSize | 91 |
| pMANOVA | 0.000645 |
| p.adjustMANOVA | 0.000815 |
| s.dist | 0.239 |
| s.KO | -0.223 |
| s.drug | -0.0841 |
| p.KO | 0.000229 |
| p.drug | 0.165 |
| Gene | KO | drug |
|---|---|---|
| CREBBP | -10387 | -10534 |
| GLUD1 | -9514 | -10318 |
| PPARA | -8366 | -11101 |
| SOD2 | -11234 | -8262 |
| PRKAB2 | -7701 | -10925 |
| CRTC3 | -11300 | -7391 |
| ATF2 | -8942 | -9289 |
| CARM1 | -11211 | -7070 |
| IDH2 | -11009 | -7176 |
| TFB2M | -8527 | -9028 |
| ATP5F1B | -8379 | -9015 |
| GABPA | -8877 | -8320 |
| NCOA2 | -6710 | -10904 |
| PPARGC1B | -11191 | -6465 |
| MAPK14 | -9586 | -7538 |
| TBL1X | -8568 | -8247 |
| SAMM50 | -10241 | -5933 |
| RXRA | -9975 | -6008 |
| TGS1 | -7713 | -7446 |
| NRF1 | -9525 | -5711 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ACSS2 | -11053 | 7142 |
| ALAS1 | 4171 | -10735 |
| APOO | -6201 | 11850 |
| APOOL | -418 | -10518 |
| ATF2 | -8942 | -9289 |
| ATP5F1A | 7998 | -9624 |
| ATP5F1B | -8379 | -9015 |
| ATP5F1C | -287 | 12518 |
| ATP5F1D | -1232 | 12979 |
| ATP5F1E | -1539 | 10947 |
| ATP5MC1 | 10755 | 12985 |
| ATP5MC2 | -3774 | 12406 |
| ATP5MC3 | 2759 | 11175 |
| ATP5ME | -5746 | 13136 |
| ATP5MF | -8135 | 13076 |
| ATP5MG | -6440 | 13061 |
| ATP5PB | 6563 | -5803 |
| ATP5PD | -3802 | 13152 |
| ATP5PF | -6437 | 12713 |
| ATP5PO | -8733 | 12858 |
| CALM1 | 11329 | -6948 |
| CAMK4 | 7340 | -6703 |
| CARM1 | -11211 | -7070 |
| CHCHD3 | 10648 | -7217 |
| CHCHD6 | 2521 | 520 |
| CHD9 | 6368 | -9728 |
| CREB1 | -4739 | -8655 |
| CREBBP | -10387 | -10534 |
| CRTC1 | -6916 | -2898 |
| CRTC2 | -7623 | 1945 |
| CRTC3 | -11300 | -7391 |
| CYCS | -2044 | 10884 |
| DMAC2L | 10867 | 2617 |
| DNAJC11 | 7371 | 11021 |
| ESRRA | -11153 | 10724 |
| GABPA | -8877 | -8320 |
| GABPB1 | -1712 | -4472 |
| GLUD1 | -9514 | -10318 |
| GLUD2 | -5197 | -4510 |
| HCFC1 | 7731 | -9516 |
| HDAC3 | 10500 | -7476 |
| HELZ2 | 6737 | -11221 |
| HSPA9 | -6955 | 6549 |
| IDH2 | -11009 | -7176 |
| IMMT | 9914 | -9786 |
| MAPK11 | 10678 | 4248 |
| MAPK12 | -5292 | 10444 |
| MAPK14 | -9586 | -7538 |
| MED1 | 4565 | -10954 |
| MEF2C | -8056 | -4261 |
| MEF2D | -282 | -10543 |
| MICOS10 | 10505 | 12560 |
| MICOS13 | -6382 | 12670 |
| MT-ATP6 | 8420 | 13018 |
| MT-ATP8 | 9404 | 12604 |
| MTERF1 | -5272 | 6828 |
| MTX1 | 10553 | 11989 |
| MTX2 | -10384 | 10819 |
| NCOA1 | 4263 | -8396 |
| NCOA2 | -6710 | -10904 |
| NCOA6 | -1205 | -9301 |
| NCOR1 | -8203 | -6322 |
| NR1D1 | -10996 | 4719 |
| NRF1 | -9525 | -5711 |
| PERM1 | 6967 | 10353 |
| POLG2 | 7584 | 4971 |
| POLRMT | -9425 | -2950 |
| PPARA | -8366 | -11101 |
| PPARGC1A | 10444 | -5499 |
| PPARGC1B | -11191 | -6465 |
| PPRC1 | -10837 | -4822 |
| PRKAA2 | -3279 | -8609 |
| PRKAB1 | -5203 | -6241 |
| PRKAB2 | -7701 | -10925 |
| PRKAG1 | -6785 | -7254 |
| PRKAG2 | 9883 | -5624 |
| RXRA | -9975 | -6008 |
| SAMM50 | -10241 | -5933 |
| SIRT3 | -2652 | 10081 |
| SIRT4 | -4587 | 9390 |
| SIRT5 | -1620 | 6695 |
| SMARCD3 | 11978 | 11422 |
| SOD2 | -11234 | -8262 |
| SSBP1 | 12278 | 12643 |
| TBL1X | -8568 | -8247 |
| TBL1XR1 | -3958 | -9641 |
| TFAM | -2311 | -6575 |
| TFB1M | -11120 | 4823 |
| TFB2M | -8527 | -9028 |
| TGS1 | -7713 | -7446 |
| TMEM11 | -10746 | 7881 |
Phospholipid metabolism
| metric | value |
|---|---|
| setSize | 186 |
| pMANOVA | 3.53e-12 |
| p.adjustMANOVA | 1.41e-11 |
| s.dist | 0.319 |
| s.KO | -0.147 |
| s.drug | -0.283 |
| p.KO | 0.000525 |
| p.drug | 2.57e-11 |
| Gene | KO | drug |
|---|---|---|
| PLEKHA2 | -11451 | -10431 |
| MTMR12 | -10618 | -11138 |
| CSNK2A1 | -10604 | -10586 |
| CPNE3 | -9909 | -10952 |
| PITPNM1 | -9832 | -10911 |
| PIKFYVE | -10388 | -10306 |
| PLA2G4A | -11353 | -9250 |
| CSNK2A2 | -9949 | -10332 |
| DDHD2 | -11261 | -9027 |
| AGPAT5 | -11194 | -8876 |
| AGPAT3 | -10865 | -9124 |
| RAB14 | -9162 | -10367 |
| PIK3CB | -9217 | -10250 |
| PITPNB | -10732 | -8304 |
| PNPLA8 | -10281 | -8614 |
| SBF2 | -7579 | -11053 |
| DDHD1 | -8454 | -9590 |
| PNPLA3 | -9617 | -8407 |
| MTMR3 | -7836 | -10186 |
| MBOAT2 | -9788 | -8124 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ABHD3 | 3550 | 11200 |
| ABHD4 | -4078 | -7842 |
| ACHE | 9948 | -44 |
| ACP6 | 12363 | -5186 |
| AGK | 12316 | 10534 |
| AGPAT1 | 12340 | -8581 |
| AGPAT2 | -7585 | 10548 |
| AGPAT3 | -10865 | -9124 |
| AGPAT4 | -11056 | 9424 |
| AGPAT5 | -11194 | -8876 |
| ARF1 | -9163 | -5561 |
| ARF3 | 3251 | -6648 |
| BCHE | 7338 | 10241 |
| CDIPT | -8739 | -6855 |
| CDS1 | -5536 | -2686 |
| CDS2 | 12495 | -9650 |
| CEPT1 | -2571 | -8803 |
| CHAT | 6776 | -3180 |
| CHKA | -9195 | 12581 |
| CHKB | 11206 | 12778 |
| CHPT1 | -2663 | -5035 |
| CPNE1 | -7557 | 11964 |
| CPNE3 | -9909 | -10952 |
| CPNE7 | 217 | 12014 |
| CRLS1 | -9065 | -3075 |
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| CSNK2B | -9249 | 12011 |
| DDHD1 | -8454 | -9590 |
| DDHD2 | -11261 | -9027 |
| DGAT1 | -3372 | 10410 |
| DGAT2 | -10973 | 9278 |
| ENPP6 | -380 | 4251 |
| ETNK1 | -6875 | -4750 |
| ETNK2 | 4136 | -8591 |
| FIG4 | 10135 | -5525 |
| GDE1 | -5489 | -5600 |
| GDPD1 | 6538 | -5821 |
| GDPD3 | -8814 | 10429 |
| GDPD5 | -5058 | -4242 |
| GNPAT | -3027 | 5570 |
| GPAM | 9347 | -8178 |
| GPAT2 | -3610 | 6349 |
| GPAT3 | -3147 | -8656 |
| GPAT4 | -9453 | -6583 |
| GPCPD1 | -11362 | 12472 |
| GPD1 | 1 | 6256 |
| GPD1L | -393 | 5259 |
| GPD2 | 8694 | -9821 |
| HADHA | 10596 | -8030 |
| HADHB | -424 | -8570 |
| INPP4A | -6949 | -8897 |
| INPP4B | 7799 | 1151 |
| INPP5D | 12494 | -6335 |
| INPP5E | -9231 | 9571 |
| INPP5F | -6267 | -8385 |
| INPP5J | 2774 | 6306 |
| INPP5K | -2145 | 5151 |
| INPPL1 | -7710 | -4327 |
| LCLAT1 | -5766 | -9874 |
| LIPH | 3458 | 5131 |
| LPCAT1 | -3028 | -5868 |
| LPCAT2 | -5840 | -6904 |
| LPCAT3 | 12306 | 8926 |
| LPCAT4 | -10814 | 11636 |
| LPGAT1 | 9789 | -9221 |
| LPIN1 | -10795 | -5721 |
| LPIN2 | 7561 | -11087 |
| LPIN3 | 3240 | 9122 |
| MBOAT1 | -7369 | -4354 |
| MBOAT2 | -9788 | -8124 |
| MBOAT7 | 4107 | -7700 |
| MFSD2A | -11012 | 3357 |
| MGLL | 12726 | -10604 |
| MIGA1 | -4880 | -10227 |
| MIGA2 | -8827 | 11729 |
| MTM1 | -4584 | -7808 |
| MTMR1 | 10448 | -7007 |
| MTMR10 | 9939 | -6395 |
| MTMR12 | -10618 | -11138 |
| MTMR14 | -5165 | 7975 |
| MTMR2 | -6094 | -9336 |
| MTMR3 | -7836 | -10186 |
| MTMR4 | -4934 | -8877 |
| MTMR6 | -5385 | -8925 |
| MTMR7 | -5015 | 4886 |
| MTMR9 | -9350 | -8112 |
| OCRL | -3909 | -8515 |
| OSBPL10 | 12422 | -10923 |
| OSBPL5 | -8362 | -5759 |
| OSBPL8 | -6521 | -10242 |
| PCTP | 12215 | -8293 |
| PCYT1A | 1479 | -5733 |
| PCYT2 | -7783 | 12466 |
| PEMT | -5793 | 8198 |
| PGS1 | -5196 | -5724 |
| PHOSPHO1 | -4356 | 8844 |
| PI4K2A | -7282 | -6755 |
| PI4K2B | -4371 | -7468 |
| PI4KA | 10503 | -5896 |
| PI4KB | 5739 | -10289 |
| PIK3C2A | -5604 | -9519 |
| PIK3C2B | 7510 | -6252 |
| PIK3C3 | -8170 | -7865 |
| PIK3CA | -5426 | -9599 |
| PIK3CB | -9217 | -10250 |
| PIK3CD | 8125 | -9524 |
| PIK3CG | 8376 | -5110 |
| PIK3R1 | 10169 | -9568 |
| PIK3R2 | -6506 | -5848 |
| PIK3R3 | 9654 | -3457 |
| PIK3R4 | 9611 | -9422 |
| PIK3R5 | -1767 | 107 |
| PIK3R6 | 12716 | -2472 |
| PIKFYVE | -10388 | -10306 |
| PIP4K2A | 8236 | -8090 |
| PIP4K2B | -3399 | 1126 |
| PIP4K2C | 8425 | -9498 |
| PIP5K1A | 7428 | -9178 |
| PIP5K1B | 6218 | -6738 |
| PIP5K1C | -7525 | -1015 |
| PISD | -10547 | 4750 |
| PITPNB | -10732 | -8304 |
| PITPNM1 | -9832 | -10911 |
| PITPNM2 | -6158 | -4679 |
| PITPNM3 | 462 | 2559 |
| PLA1A | 1097 | 1226 |
| PLA2G10 | 301 | 4728 |
| PLA2G12A | 8760 | -7403 |
| PLA2G15 | -6553 | -5088 |
| PLA2G4A | -11353 | -9250 |
| PLA2G4B | 6200 | 13064 |
| PLA2G4C | 9981 | -5934 |
| PLA2G4D | 1634 | 4664 |
| PLA2G5 | -11263 | 7586 |
| PLA2G6 | -8707 | 12727 |
| PLA2R1 | 12453 | -6182 |
| PLAAT1 | 2388 | -4908 |
| PLAAT3 | 12878 | 12588 |
| PLAAT4 | 10410 | 12384 |
| PLB1 | -664 | 4620 |
| PLBD1 | 12507 | 39 |
| PLD1 | 12766 | -9763 |
| PLD2 | -7320 | -7936 |
| PLD3 | 9531 | -3623 |
| PLD4 | 2571 | 7880 |
| PLD6 | -11240 | -2847 |
| PLEKHA1 | -5829 | -10175 |
| PLEKHA2 | -11451 | -10431 |
| PLEKHA3 | -9653 | -6310 |
| PLEKHA4 | -3065 | 10468 |
| PLEKHA5 | -8831 | -7991 |
| PLEKHA6 | 10937 | 7485 |
| PLEKHA8 | 5033 | -9481 |
| PNPLA2 | -6634 | -2945 |
| PNPLA3 | -9617 | -8407 |
| PNPLA6 | -9579 | -4893 |
| PNPLA7 | 4383 | 9842 |
| PNPLA8 | -10281 | -8614 |
| PTDSS1 | -4830 | -8543 |
| PTDSS2 | 10798 | 5487 |
| PTEN | -6933 | -8533 |
| PTPMT1 | -6485 | 12300 |
| PTPN13 | 12622 | -7833 |
| RAB14 | -9162 | -10367 |
| RAB4A | 6470 | -4166 |
| RAB5A | -7843 | -8483 |
| RUFY1 | -2346 | 11546 |
| SACM1L | -7553 | -7666 |
| SBF1 | -7013 | -7405 |
| SBF2 | -7579 | -11053 |
| SELENOI | -6323 | -9929 |
| SLC44A1 | 3030 | -8195 |
| SLC44A2 | 11423 | -6429 |
| SLC44A3 | 9846 | -2785 |
| SLC44A5 | 8809 | -7261 |
| STARD10 | -11280 | 10122 |
| STARD7 | 5228 | -9022 |
| SYNJ1 | -6939 | -6072 |
| SYNJ2 | 7547 | -5487 |
| TAZ | 8218 | 12600 |
| TMEM86B | -4684 | 10657 |
| TNFAIP8 | -8871 | -5353 |
| TNFAIP8L1 | -9972 | -6812 |
| TNFAIP8L3 | 6293 | 3816 |
| VAC14 | -9751 | -7774 |
Signaling by the B Cell Receptor (BCR)
| metric | value |
|---|---|
| setSize | 106 |
| pMANOVA | 5.99e-05 |
| p.adjustMANOVA | 0.000103 |
| s.dist | 0.255 |
| s.KO | -0.234 |
| s.drug | -0.102 |
| p.KO | 3.07e-05 |
| p.drug | 0.0699 |
| Gene | KO | drug |
|---|---|---|
| ITPR1 | -11523 | -11275 |
| PSME4 | -10581 | -10843 |
| NFKB1 | -10600 | -10807 |
| RELA | -10894 | -10457 |
| PSMD1 | -9192 | -10441 |
| NCK1 | -9577 | -9993 |
| NFATC1 | -9218 | -9228 |
| NFATC3 | -8816 | -9311 |
| ITPR2 | -7642 | -10382 |
| PSMD5 | -9642 | -8039 |
| PSMA7 | -10164 | -7607 |
| ORAI1 | -8021 | -9480 |
| SOS1 | -7259 | -9921 |
| NFATC2 | -11381 | -6299 |
| REL | -6969 | -10200 |
| PSMD2 | -6801 | -10378 |
| GRB2 | -6137 | -10524 |
| PPP3CB | -8974 | -7138 |
| PSMD8 | -9103 | -6526 |
| BCL10 | -8460 | -6848 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AHCYL1 | 5721 | -10813 |
| BCL10 | -8460 | -6848 |
| BLK | -618 | -3097 |
| BLNK | 5998 | -3402 |
| BTK | -1000 | 2113 |
| BTRC | -4856 | -8431 |
| CALM1 | 11329 | -6948 |
| CARD11 | -3145 | 1745 |
| CD22 | 3605 | 5134 |
| CD79A | -5516 | 1600 |
| CD79B | 5399 | 1704 |
| CHUK | -2503 | -6194 |
| CUL1 | 11196 | -4981 |
| FBXW11 | -5120 | -11073 |
| FKBP1A | 11955 | 9396 |
| FYN | -11380 | -3570 |
| GRB2 | -6137 | -10524 |
| HRAS | -8054 | 12320 |
| IKBKB | 11568 | 8115 |
| IKBKG | 8074 | 8626 |
| ITPR1 | -11523 | -11275 |
| ITPR2 | -7642 | -10382 |
| ITPR3 | 969 | -10878 |
| KRAS | 12719 | -8619 |
| LYN | 11194 | -6028 |
| MALT1 | -3704 | -5480 |
| MAP3K7 | -4055 | -7297 |
| NCK1 | -9577 | -9993 |
| NFATC1 | -9218 | -9228 |
| NFATC2 | -11381 | -6299 |
| NFATC3 | -8816 | -9311 |
| NFKB1 | -10600 | -10807 |
| NFKBIA | -8197 | 739 |
| NFKBIB | -8585 | 9505 |
| NFKBIE | -3277 | -6245 |
| NRAS | -3309 | -9724 |
| ORAI1 | -8021 | -9480 |
| ORAI2 | 10030 | -10559 |
| PIK3AP1 | 9731 | -5428 |
| PIK3CD | 8125 | -9524 |
| PIK3R1 | 10169 | -9568 |
| PLCG2 | -6464 | -3252 |
| PPIA | 3756 | 13113 |
| PPP3CA | 10840 | -10652 |
| PPP3CB | -8974 | -7138 |
| PPP3R1 | -5334 | -9996 |
| PRKCB | 12683 | -6223 |
| PSMA1 | -9646 | 10578 |
| PSMA2 | -4002 | -4430 |
| PSMA3 | -5668 | 12561 |
| PSMA4 | -9907 | 11447 |
| PSMA5 | 5538 | 826 |
| PSMA6 | -3328 | 8997 |
| PSMA7 | -10164 | -7607 |
| PSMB1 | -6139 | 12480 |
| PSMB10 | 9537 | 11663 |
| PSMB2 | -3364 | 8976 |
| PSMB3 | 7905 | 13078 |
| PSMB4 | -1370 | 12998 |
| PSMB5 | -6937 | -2970 |
| PSMB6 | -6537 | 10901 |
| PSMB7 | -8656 | 12462 |
| PSMB8 | -9783 | 11153 |
| PSMB9 | -9810 | 10733 |
| PSMC1 | -3547 | -3814 |
| PSMC2 | -9185 | 11068 |
| PSMC3 | -1273 | 12327 |
| PSMC4 | -7156 | 12714 |
| PSMC5 | 7024 | 12041 |
| PSMC6 | -7069 | 697 |
| PSMD1 | -9192 | -10441 |
| PSMD10 | -6869 | 1286 |
| PSMD11 | 7720 | -8518 |
| PSMD12 | 813 | 8775 |
| PSMD13 | -5300 | 12140 |
| PSMD14 | -10615 | 8461 |
| PSMD2 | -6801 | -10378 |
| PSMD3 | -8058 | -4798 |
| PSMD4 | 743 | 11756 |
| PSMD5 | -9642 | -8039 |
| PSMD6 | -7577 | 12228 |
| PSMD7 | -6198 | -6043 |
| PSMD8 | -9103 | -6526 |
| PSMD9 | -7638 | -3346 |
| PSME1 | -8654 | 11878 |
| PSME2 | -4231 | 12869 |
| PSME3 | 11811 | -7813 |
| PSME4 | -10581 | -10843 |
| PSMF1 | -7549 | -4369 |
| PTPN6 | 3206 | 5586 |
| RASGRP1 | 4603 | -4416 |
| RASGRP3 | -7415 | 5200 |
| REL | -6969 | -10200 |
| RELA | -10894 | -10457 |
| RPS27A | 5357 | 6464 |
| SEM1 | -9978 | 13108 |
| SH3KBP1 | 6290 | -8226 |
| SKP1 | 179 | -9573 |
| SOS1 | -7259 | -9921 |
| STIM1 | 12341 | -6990 |
| SYK | 11473 | -3487 |
| TRPC1 | 5911 | -6807 |
| UBA52 | -6807 | 11639 |
| UBB | -5602 | 12024 |
| UBC | -10397 | 7017 |
| VAV1 | -4339 | 5985 |
Pyruvate metabolism and Citric Acid (TCA) cycle
| metric | value |
|---|---|
| setSize | 52 |
| pMANOVA | 0.00175 |
| p.adjustMANOVA | 0.0021 |
| s.dist | 0.298 |
| s.KO | -0.235 |
| s.drug | -0.183 |
| p.KO | 0.00334 |
| p.drug | 0.0225 |
| Gene | KO | drug |
|---|---|---|
| ME2 | -10992 | -10086 |
| SDHA | -10480 | -9986 |
| SLC16A1 | -10562 | -9859 |
| CS | -9273 | -10545 |
| MDH2 | -10661 | -8768 |
| DLST | -8194 | -10831 |
| IDH2 | -11009 | -7176 |
| DLD | -9253 | -8294 |
| PDP2 | -8514 | -8538 |
| DLAT | -8123 | -7745 |
| RXRA | -9975 | -6008 |
| PDK3 | -6613 | -8798 |
| SUCLG2 | -6338 | -8917 |
| PDPR | -6645 | -8103 |
| PDK1 | -5018 | -9225 |
| PDHX | -9039 | -4928 |
| LDHA | -4687 | -9205 |
| OGDH | -5384 | -7828 |
| IDH3A | -8898 | -3067 |
| SDHD | -9641 | -2716 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ACO2 | -5040 | -2386 |
| ADHFE1 | 5031 | 7843 |
| BSG | -5149 | 12544 |
| CS | -9273 | -10545 |
| D2HGDH | 8528 | 8058 |
| DLAT | -8123 | -7745 |
| DLD | -9253 | -8294 |
| DLST | -8194 | -10831 |
| FAHD1 | -6287 | 7691 |
| FH | -396 | 11082 |
| GLO1 | -8377 | 4629 |
| GSTZ1 | 10777 | 8707 |
| HAGH | 10014 | 11571 |
| IDH2 | -11009 | -7176 |
| IDH3A | -8898 | -3067 |
| IDH3B | -4300 | -4551 |
| IDH3G | 117 | 9128 |
| L2HGDH | 7092 | -9403 |
| LDHA | -4687 | -9205 |
| LDHAL6A | -1233 | 5274 |
| LDHAL6B | 5276 | -3235 |
| LDHB | 3274 | 2139 |
| MDH2 | -10661 | -8768 |
| ME1 | 6821 | -7488 |
| ME2 | -10992 | -10086 |
| ME3 | -8506 | 7768 |
| MPC1 | -6561 | 11380 |
| MPC2 | -5160 | 7935 |
| NNT | 4483 | -10790 |
| OGDH | -5384 | -7828 |
| PDHA1 | -10664 | 11842 |
| PDHB | -3368 | 12152 |
| PDHX | -9039 | -4928 |
| PDK1 | -5018 | -9225 |
| PDK2 | 11377 | 2039 |
| PDK3 | -6613 | -8798 |
| PDK4 | 10934 | -3798 |
| PDP1 | 11745 | -9417 |
| PDP2 | -8514 | -8538 |
| PDPR | -6645 | -8103 |
| PPARD | -11069 | 6617 |
| RXRA | -9975 | -6008 |
| SDHA | -10480 | -9986 |
| SDHB | -299 | 5982 |
| SDHC | 9345 | -5559 |
| SDHD | -9641 | -2716 |
| SLC16A1 | -10562 | -9859 |
| SLC16A3 | 11791 | -6452 |
| SUCLA2 | 3325 | -7651 |
| SUCLG1 | 1114 | 10597 |
| SUCLG2 | -6338 | -8917 |
| VDAC1 | 10321 | -414 |
Nervous system development
| metric | value |
|---|---|
| setSize | 522 |
| pMANOVA | 8.27e-12 |
| p.adjustMANOVA | 2.83e-11 |
| s.dist | 0.19 |
| s.KO | -0.119 |
| s.drug | -0.149 |
| p.KO | 3.47e-06 |
| p.drug | 5.53e-09 |
| Gene | KO | drug |
|---|---|---|
| MMP9 | -11544 | -11274 |
| NRP2 | -11503 | -11235 |
| ITGA5 | -11427 | -11242 |
| SEMA5A | -11537 | -10912 |
| NUMB | -11352 | -10801 |
| MYO10 | -11283 | -10773 |
| HSPA8 | -10759 | -11259 |
| SREBF2 | -10833 | -10659 |
| PSME4 | -10581 | -10843 |
| GSPT1 | -11018 | -10260 |
| CSNK2A1 | -10604 | -10586 |
| PAK1 | -11464 | -9735 |
| YES1 | -10903 | -10141 |
| EPHB4 | -11068 | -9972 |
| DLG4 | -11488 | -9265 |
| MYH9 | -10470 | -10143 |
| ARPC2 | -10726 | -9893 |
| HMGCR | -9941 | -10570 |
| SLIT2 | -11365 | -9218 |
| TLN1 | -10315 | -10054 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ABL1 | 11663 | -8885 |
| ABL2 | -6876 | -10017 |
| ABLIM1 | 12140 | -5473 |
| ABLIM2 | 8499 | -1532 |
| ABLIM3 | 5148 | -9372 |
| ACTB | 10250 | 11107 |
| ACTG1 | 10519 | -8874 |
| ACTR2 | 1714 | -9008 |
| ACTR3 | -7983 | -9109 |
| ADAM10 | 11732 | -10321 |
| ADGRG6 | 12571 | -7103 |
| ADGRV1 | 11199 | 2246 |
| AGAP2 | 12302 | -4149 |
| AGRN | 12518 | -11205 |
| AKAP5 | 6930 | 2937 |
| ALCAM | 8663 | -10885 |
| ANK1 | 5860 | -2296 |
| ANK2 | 9200 | -6191 |
| ANK3 | 6882 | -11122 |
| AP2A1 | -6997 | -8134 |
| AP2A2 | -6539 | -5045 |
| AP2B1 | 12427 | -10984 |
| AP2M1 | 10151 | -6181 |
| AP2S1 | 8881 | 6008 |
| APH1A | 3143 | -9778 |
| APH1B | 12138 | -9680 |
| ARHGAP35 | 10763 | -10603 |
| ARHGAP39 | 2704 | -3971 |
| ARHGEF11 | 9309 | -5070 |
| ARHGEF12 | -4861 | -10733 |
| ARHGEF28 | 9466 | -7473 |
| ARHGEF7 | 4838 | -2908 |
| ARPC1A | -10481 | 3397 |
| ARPC1B | -11473 | -6676 |
| ARPC2 | -10726 | -9893 |
| ARPC3 | -8304 | 12552 |
| ARPC4 | -4723 | 7412 |
| ARPC5 | 6471 | -8526 |
| ARTN | 3982 | 5769 |
| CACNA1C | 11357 | -4385 |
| CACNA1D | 12251 | 7919 |
| CACNA1G | 12204 | 2461 |
| CACNA1H | 11853 | -9013 |
| CACNA1I | -5455 | -467 |
| CACNA1S | 12889 | 12848 |
| CACNB1 | 8009 | 12232 |
| CACNB2 | -2901 | 9935 |
| CACNB3 | -10750 | 131 |
| CACNB4 | -8708 | 2250 |
| CAP1 | -4846 | -10201 |
| CAP2 | -1498 | -6337 |
| CASC3 | 3621 | -10268 |
| CD24 | -2000 | -10169 |
| CD72 | -627 | 3306 |
| CDC42 | -7820 | -8450 |
| CDK5 | 11365 | 11879 |
| CDK5R1 | -8980 | -5890 |
| CFL1 | 121 | 10816 |
| CLASP1 | -6791 | -4673 |
| CLASP2 | -2745 | -8780 |
| CLTA | -11070 | -5228 |
| CLTB | -4297 | 11260 |
| CLTC | 7619 | -11201 |
| CLTCL1 | -6977 | -6100 |
| CNTN1 | 10624 | -6687 |
| CNTN2 | 631 | 4882 |
| CNTNAP1 | 7446 | -5304 |
| COL4A1 | 12144 | -2998 |
| COL4A2 | 12287 | -5744 |
| COL4A3 | -6350 | 1696 |
| COL4A5 | 12376 | 8368 |
| COL6A1 | 11520 | -9499 |
| COL6A2 | 12038 | -8896 |
| COL6A3 | -7285 | -8785 |
| COL6A5 | 12043 | -4664 |
| COL6A6 | 3485 | 3246 |
| COL9A2 | 6591 | 12969 |
| COL9A3 | -10080 | 11319 |
| CREB1 | -4739 | -8655 |
| CRMP1 | -9467 | 8204 |
| CSNK2A1 | -10604 | -10586 |
| CSNK2A2 | -9949 | -10332 |
| CSNK2B | -9249 | 12011 |
| CUL2 | -2032 | -10093 |
| CXCR4 | -6274 | -7315 |
| CYP51A1 | -11252 | -9071 |
| DAB1 | 9510 | 2041 |
| DAG1 | 6148 | -8573 |
| DCC | 2949 | -9359 |
| DLG1 | -9408 | -9725 |
| DLG3 | 9011 | -7397 |
| DLG4 | -11488 | -9265 |
| DNM1 | 11730 | 13133 |
| DNM2 | -8486 | -5605 |
| DNM3 | 7268 | -4103 |
| DOCK1 | 10264 | -10777 |
| DOK1 | 1398 | -8254 |
| DOK4 | -10395 | 586 |
| DOK5 | -10107 | 4942 |
| DOK6 | 5775 | -5585 |
| DPYSL2 | -8515 | -6617 |
| DPYSL3 | 8962 | -9979 |
| DPYSL4 | 2668 | -540 |
| DPYSL5 | 12108 | 943 |
| DRP2 | -8595 | 8869 |
| DSCAML1 | -6067 | -4372 |
| EFNA1 | 10320 | -3995 |
| EFNA2 | 4840 | 6472 |
| EFNA3 | -8124 | 349 |
| EFNA4 | -5971 | 1975 |
| EFNA5 | 12768 | -9515 |
| EFNB1 | 10712 | -7077 |
| EFNB2 | -6633 | -10416 |
| EFNB3 | 6767 | -10423 |
| EGFR | 2126 | -11093 |
| EGR2 | 954 | -3948 |
| EIF4A3 | -628 | -6343 |
| EIF4G1 | 9159 | -10287 |
| ELOB | -9703 | 13020 |
| ELOC | -7394 | 12764 |
| ENAH | -5418 | -8470 |
| EPHA1 | 5746 | 4236 |
| EPHA10 | 4822 | -1507 |
| EPHA2 | 12770 | -6176 |
| EPHA4 | -11465 | -8650 |
| EPHA5 | -3260 | -3285 |
| EPHA6 | 9254 | -1582 |
| EPHA7 | 678 | 4787 |
| EPHA8 | -3259 | -859 |
| EPHB1 | 11576 | -10174 |
| EPHB2 | -10975 | -6661 |
| EPHB3 | 5660 | 3815 |
| EPHB4 | -11068 | -9972 |
| EPHB6 | -11501 | 8239 |
| ERBB2 | 3816 | -5849 |
| ETF1 | -5515 | -9496 |
| EVL | 9744 | 10446 |
| EZR | -11288 | -7422 |
| FARP2 | 7041 | -460 |
| FAU | -8610 | 13102 |
| FES | -8923 | 54 |
| FGFR1 | -10613 | -7876 |
| FLRT3 | -7271 | -9898 |
| FRS2 | -6455 | -9318 |
| FYN | -11380 | -3570 |
| GAB1 | -6660 | -8223 |
| GAB2 | -8602 | -8733 |
| GAP43 | 12703 | -6230 |
| GDNF | 12813 | -11239 |
| GFRA1 | -4667 | 3017 |
| GFRA2 | 12100 | -6635 |
| GIT1 | 1429 | -3900 |
| GPC1 | 1951 | -7922 |
| GRB10 | -7242 | -10690 |
| GRB2 | -6137 | -10524 |
| GRB7 | -7561 | 965 |
| GRIN1 | 1772 | 1917 |
| GRIN2B | -86 | -4571 |
| GSK3B | 7016 | -10755 |
| GSPT1 | -11018 | -10260 |
| GSPT2 | -5509 | -6727 |
| HDAC2 | -9786 | -6704 |
| HMGCR | -9941 | -10570 |
| HOXA2 | 8898 | 12312 |
| HRAS | -8054 | 12320 |
| HSP90AA1 | 11397 | -7534 |
| HSP90AB1 | -9168 | -9114 |
| HSPA8 | -10759 | -11259 |
| IRS2 | -1938 | -10094 |
| ISL1 | -4207 | 3822 |
| ITGA1 | 12258 | -10552 |
| ITGA10 | -11438 | 1671 |
| ITGA2 | 8062 | -11213 |
| ITGA2B | -5878 | 9166 |
| ITGA5 | -11427 | -11242 |
| ITGA9 | 12791 | -9989 |
| ITGAV | 144 | -11011 |
| ITGB1 | -3655 | -11215 |
| ITGB3 | 12688 | -11286 |
| ITSN1 | -10095 | -8537 |
| KALRN | -7355 | -9904 |
| KCNQ2 | -5921 | 12096 |
| KCNQ3 | 9606 | -7783 |
| KIF4A | 7632 | -878 |
| KRAS | 12719 | -8619 |
| L1CAM | 12673 | -11189 |
| LAMA1 | 12802 | -10091 |
| LAMA2 | -8729 | -4165 |
| LAMB1 | -9087 | -10329 |
| LAMC1 | 12854 | -11227 |
| LDB1 | 4147 | 748 |
| LHX2 | 10308 | -302 |
| LHX4 | 11564 | -5603 |
| LHX9 | 9237 | -4741 |
| LIMK1 | 8691 | 8272 |
| LIMK2 | -6025 | 1750 |
| LYN | 11194 | -6028 |
| LYPLA2 | 5663 | 5825 |
| MAGOH | -5607 | 12947 |
| MAGOHB | -7769 | 12200 |
| MAP2K1 | 10407 | -10989 |
| MAP2K2 | -8526 | 6661 |
| MAPK1 | -9173 | -10906 |
| MAPK11 | 10678 | 4248 |
| MAPK12 | -5292 | 10444 |
| MAPK13 | -475 | 10415 |
| MAPK14 | -9586 | -7538 |
| MAPK3 | -9742 | -9271 |
| MAPK7 | -7980 | -4568 |
| MAPK8 | -3223 | -5847 |
| MBP | -2678 | 984 |
| MET | 10796 | -11047 |
| MMP2 | 12429 | -8269 |
| MMP9 | -11544 | -11274 |
| MSI1 | 9573 | 10261 |
| MSN | 10752 | -10996 |
| MYH10 | 10412 | -9280 |
| MYH11 | -3795 | 3493 |
| MYH14 | -7452 | -2004 |
| MYH9 | -10470 | -10143 |
| MYL12A | 8344 | -4820 |
| MYL12B | -8083 | 12443 |
| MYL6 | -6131 | 6237 |
| MYL9 | 7628 | 11186 |
| MYO10 | -11283 | -10773 |
| MYO9B | -10955 | -6713 |
| NAB1 | -7796 | -8345 |
| NAB2 | -11022 | 8542 |
| NCAM1 | -5432 | 8870 |
| NCAN | 3533 | -1773 |
| NCBP1 | -7784 | -5234 |
| NCBP2 | -6378 | -6281 |
| NCK1 | -9577 | -9993 |
| NCK2 | -10111 | -6626 |
| NCSTN | 11563 | -4277 |
| NELL2 | 12693 | -7880 |
| NEO1 | 12310 | -9227 |
| NFASC | -4408 | 5984 |
| NGEF | 7391 | -10445 |
| NRAS | -3309 | -9724 |
| NRCAM | 9844 | -9135 |
| NRP1 | 12492 | -10673 |
| NRP2 | -11503 | -11235 |
| NRTN | -6424 | 10119 |
| NTN1 | 12777 | -9806 |
| NTN4 | -8804 | -7703 |
| NUMB | -11352 | -10801 |
| PABPC1 | -7033 | -10406 |
| PAK1 | -11464 | -9735 |
| PAK2 | -6371 | -10285 |
| PAK3 | 9899 | -7417 |
| PAK4 | -8948 | -6862 |
| PAK5 | 10389 | -4026 |
| PAK6 | 1878 | 388 |
| PDLIM7 | -6297 | 11933 |
| PFN1 | -1501 | -842 |
| PFN2 | 10490 | -10371 |
| PIK3CA | -5426 | -9599 |
| PIK3CB | -9217 | -10250 |
| PIK3CD | 8125 | -9524 |
| PIK3R1 | 10169 | -9568 |
| PIK3R2 | -6506 | -5848 |
| PIK3R3 | 9654 | -3457 |
| PIP5K1C | -7525 | -1015 |
| PITPNA | 7881 | -9463 |
| PLCG1 | -8518 | 10852 |
| PLXNA1 | 12834 | -10985 |
| PLXNA2 | -1563 | -6909 |
| PLXNA3 | -7350 | 1983 |
| PLXNA4 | 11726 | -9845 |
| PLXNB1 | -4940 | 12049 |
| PLXNB3 | 11348 | -6567 |
| PLXNC1 | 7782 | -4730 |
| PLXND1 | 11557 | -4291 |
| PMP22 | -958 | -9982 |
| POU3F1 | 3943 | 6293 |
| POU3F2 | 11400 | -9095 |
| PPP3CB | -8974 | -7138 |
| PRKACA | 8250 | 9679 |
| PRKACB | 8849 | -9614 |
| PRKAR2A | -5980 | -10943 |
| PRKCA | 12366 | -10396 |
| PRKCQ | 10159 | -4784 |
| PRNP | -8139 | -10664 |
| PRX | -7283 | -8489 |
| PSEN1 | -5670 | -10549 |
| PSEN2 | 10087 | 11419 |
| PSENEN | 8070 | 12798 |
| PSMA1 | -9646 | 10578 |
| PSMA2 | -4002 | -4430 |
| PSMA3 | -5668 | 12561 |
| PSMA4 | -9907 | 11447 |
| PSMA5 | 5538 | 826 |
| PSMA6 | -3328 | 8997 |
| PSMA7 | -10164 | -7607 |
| PSMB1 | -6139 | 12480 |
| PSMB10 | 9537 | 11663 |
| PSMB2 | -3364 | 8976 |
| PSMB3 | 7905 | 13078 |
| PSMB4 | -1370 | 12998 |
| PSMB5 | -6937 | -2970 |
| PSMB6 | -6537 | 10901 |
| PSMB7 | -8656 | 12462 |
| PSMB8 | -9783 | 11153 |
| PSMB9 | -9810 | 10733 |
| PSMC1 | -3547 | -3814 |
| PSMC2 | -9185 | 11068 |
| PSMC3 | -1273 | 12327 |
| PSMC4 | -7156 | 12714 |
| PSMC5 | 7024 | 12041 |
| PSMC6 | -7069 | 697 |
| PSMD1 | -9192 | -10441 |
| PSMD10 | -6869 | 1286 |
| PSMD11 | 7720 | -8518 |
| PSMD12 | 813 | 8775 |
| PSMD13 | -5300 | 12140 |
| PSMD14 | -10615 | 8461 |
| PSMD2 | -6801 | -10378 |
| PSMD3 | -8058 | -4798 |
| PSMD4 | 743 | 11756 |
| PSMD5 | -9642 | -8039 |
| PSMD6 | -7577 | 12228 |
| PSMD7 | -6198 | -6043 |
| PSMD8 | -9103 | -6526 |
| PSMD9 | -7638 | -3346 |
| PSME1 | -8654 | 11878 |
| PSME2 | -4231 | 12869 |
| PSME3 | 11811 | -7813 |
| PSME4 | -10581 | -10843 |
| PSMF1 | -7549 | -4369 |
| PSPN | -6136 | -3833 |
| PTK2 | -9167 | -10148 |
| PTPN11 | -6877 | -9390 |
| PTPRA | 192 | -8083 |
| RAC1 | -7472 | -3724 |
| RANBP9 | -7563 | -9308 |
| RAP1GAP | 10891 | 786 |
| RASA1 | 8981 | -10567 |
| RBM8A | 8447 | 9246 |
| RBX1 | -9316 | 12919 |
| RDX | -7627 | -9606 |
| RELN | -11002 | -7939 |
| RET | -87 | -1793 |
| RGMA | -9460 | -1155 |
| RGMB | -5729 | -10677 |
| RHOA | -7410 | -9917 |
| RHOB | 12575 | 6440 |
| RHOC | -6764 | -10429 |
| RND1 | -7788 | 8752 |
| RNPS1 | -10981 | -5614 |
| ROBO1 | -4716 | -10678 |
| ROBO2 | -6358 | 1760 |
| ROBO3 | -7871 | 12150 |
| ROCK1 | -3805 | -11029 |
| ROCK2 | 12303 | -9632 |
| RPL10 | -3821 | 1597 |
| RPL10A | -9707 | -8212 |
| RPL11 | -8529 | 12382 |
| RPL12 | -9329 | 12992 |
| RPL13 | -3469 | 12598 |
| RPL13A | -6854 | 6955 |
| RPL14 | -6386 | 13137 |
| RPL15 | -786 | 12153 |
| RPL17 | -8989 | 12909 |
| RPL18 | -6672 | 12800 |
| RPL18A | -6976 | 11926 |
| RPL19 | 3924 | 12911 |
| RPL21 | -6322 | 5141 |
| RPL22 | -5554 | 9520 |
| RPL22L1 | -10448 | 12221 |
| RPL23 | 5769 | 12922 |
| RPL23A | 11361 | -5257 |
| RPL24 | -4591 | 12995 |
| RPL26 | -8797 | 12658 |
| RPL26L1 | -9387 | 12770 |
| RPL27 | 6735 | 11625 |
| RPL27A | -7818 | 13051 |
| RPL28 | -5809 | 12962 |
| RPL29 | -4515 | 12915 |
| RPL3 | -6827 | -4535 |
| RPL30 | -3907 | 11096 |
| RPL31 | -8781 | 13131 |
| RPL32 | -5028 | 12983 |
| RPL34 | -9357 | 12996 |
| RPL35 | -8027 | 13097 |
| RPL35A | -1449 | 12789 |
| RPL36 | -8818 | 12868 |
| RPL36A | -4480 | 13009 |
| RPL36AL | -8216 | 12702 |
| RPL37 | -4624 | 13134 |
| RPL37A | -9347 | 12675 |
| RPL38 | 1558 | 13140 |
| RPL39 | -6168 | 11962 |
| RPL39L | -6608 | -6269 |
| RPL3L | -510 | 7904 |
| RPL4 | 11351 | 12558 |
| RPL41 | -4616 | -6074 |
| RPL5 | 4679 | 12075 |
| RPL6 | -6903 | 12730 |
| RPL7 | -3327 | -8789 |
| RPL7A | -6163 | 11708 |
| RPL8 | -7572 | 10323 |
| RPL9 | -9659 | 12806 |
| RPLP0 | -1504 | -7331 |
| RPLP1 | 9026 | 12731 |
| RPLP2 | -8225 | 12999 |
| RPS10 | -8384 | 10665 |
| RPS11 | -7725 | 12935 |
| RPS12 | -7872 | 11600 |
| RPS13 | -9450 | 12652 |
| RPS14 | -1180 | 12428 |
| RPS15 | -7430 | 12908 |
| RPS15A | -8754 | 12989 |
| RPS16 | -3844 | 12941 |
| RPS17 | -10534 | 11631 |
| RPS18 | -9122 | 12984 |
| RPS19 | -7633 | 12888 |
| RPS2 | -10222 | 8916 |
| RPS20 | -4961 | 13095 |
| RPS21 | -3001 | 13022 |
| RPS23 | 6940 | 11907 |
| RPS24 | 2369 | 13034 |
| RPS25 | -9371 | 12690 |
| RPS26 | -2615 | 13114 |
| RPS27 | 651 | 11270 |
| RPS27A | 5357 | 6464 |
| RPS27L | 7330 | 12750 |
| RPS28 | 2716 | 12485 |
| RPS29 | -652 | 9078 |
| RPS3 | -7756 | 12135 |
| RPS3A | -9170 | 5257 |
| RPS4X | -8542 | 12239 |
| RPS5 | -6283 | -7965 |
| RPS6 | -9225 | 12405 |
| RPS6KA1 | 12818 | -7761 |
| RPS6KA2 | -8378 | -9101 |
| RPS6KA3 | -8355 | -9502 |
| RPS6KA4 | 209 | 5353 |
| RPS6KA5 | -8869 | -7063 |
| RPS6KA6 | -2223 | 3989 |
| RPS7 | 5142 | 12976 |
| RPS8 | -5812 | 12745 |
| RPS9 | -8815 | 10189 |
| RPSA | 292 | 11576 |
| RRAS | -10711 | 11191 |
| SCD5 | -8562 | -8561 |
| SCN11A | -1197 | 7037 |
| SCN1B | -7035 | -4146 |
| SCN2A | 1009 | 2562 |
| SCN2B | -2178 | 1537 |
| SCN3A | -5082 | 1832 |
| SCN3B | -3989 | -3340 |
| SCN4B | 11633 | 290 |
| SCN5A | 10354 | -6646 |
| SCN7A | -2071 | 4709 |
| SCN8A | 9310 | -1922 |
| SCN9A | 6184 | 6251 |
| SDC2 | -6754 | -5737 |
| SDCBP | -7932 | -10803 |
| SEM1 | -9978 | 13108 |
| SEMA3A | -8520 | -8259 |
| SEMA4A | -31 | 5409 |
| SEMA4D | 9903 | 32 |
| SEMA5A | -11537 | -10912 |
| SEMA6A | 12824 | -7654 |
| SEMA6D | -5924 | -7539 |
| SEMA7A | 9143 | -11223 |
| SH3GL2 | 9242 | -4988 |
| SH3KBP1 | 6290 | -8226 |
| SHANK3 | 10993 | -7919 |
| SHC1 | 12549 | -9462 |
| SHC3 | -9551 | -7860 |
| SHTN1 | 11966 | -9257 |
| SIAH1 | 6081 | -3908 |
| SIAH2 | -7707 | -9583 |
| SLIT1 | 12338 | -6263 |
| SLIT2 | -11365 | -9218 |
| SLIT3 | 12621 | -9830 |
| SMARCA4 | -3679 | -7145 |
| SOS1 | -7259 | -9921 |
| SOS2 | 9761 | -9317 |
| SPTAN1 | -1079 | -7432 |
| SPTB | 8651 | 7910 |
| SPTBN1 | 12206 | -10986 |
| SPTBN2 | 10820 | -10000 |
| SPTBN4 | -6086 | -1522 |
| SPTBN5 | -472 | 5718 |
| SRC | -11388 | -7284 |
| SREBF2 | -10833 | -10659 |
| SRGAP1 | -5850 | -7090 |
| SRGAP2 | 11419 | -6780 |
| SRGAP3 | 10137 | -6776 |
| ST8SIA2 | -1592 | -3655 |
| ST8SIA4 | 8099 | -7867 |
| TEAD1 | -5400 | -10624 |
| TIAM1 | 11077 | -6419 |
| TLN1 | -10315 | -10054 |
| TRIO | 10149 | -6772 |
| TRPC1 | 5911 | -6807 |
| TRPC3 | -2298 | -2648 |
| TRPC4 | -7857 | 1978 |
| UBA52 | -6807 | 11639 |
| UBB | -5602 | 12024 |
| UBC | -10397 | 7017 |
| UNC5A | 12538 | -8663 |
| UNC5B | -7467 | -10080 |
| UNC5C | 10995 | -3568 |
| UNC5D | -7177 | -8180 |
| UPF2 | 6857 | -7169 |
| UPF3A | -8410 | 11718 |
| UPF3B | -3041 | 12685 |
| USP33 | 1911 | -8690 |
| UTRN | 9433 | -10574 |
| VASP | -9209 | -6573 |
| VAV2 | -4256 | -7899 |
| VAV3 | -7453 | 2853 |
| VLDLR | 9774 | -11204 |
| WASL | -8668 | -8587 |
| WWTR1 | 10572 | -10736 |
| YAP1 | -5571 | -10960 |
| YES1 | -10903 | -10141 |
| ZSWIM8 | 10701 | -5986 |
Metabolism
| metric | value |
|---|---|
| setSize | 1856 |
| pMANOVA | 0.00042 |
| p.adjustMANOVA | 0.00056 |
| s.dist | 0.057 |
| s.KO | -0.0501 |
| s.drug | -0.027 |
| p.KO | 0.000324 |
| p.drug | 0.0524 |
| Gene | KO | drug |
|---|---|---|
| ITPR1 | -11523 | -11275 |
| SEC24D | -11430 | -11236 |
| ARG2 | -11492 | -11033 |
| OSBP | -11432 | -11066 |
| PPP2R5D | -11383 | -11113 |
| IQGAP1 | -11188 | -11226 |
| NCOA3 | -11270 | -11034 |
| B4GALT1 | -11375 | -10725 |
| HS3ST3B1 | -11527 | -10530 |
| PLEKHA2 | -11451 | -10431 |
| XYLT1 | -11081 | -10705 |
| MTMR12 | -10618 | -11138 |
| ADCY7 | -11317 | -10422 |
| LRP12 | -10595 | -11129 |
| SREBF2 | -10833 | -10659 |
| PSME4 | -10581 | -10843 |
| CSGALNACT2 | -10808 | -10564 |
| PPP2CB | -11374 | -10028 |
| PYGB | -11296 | -9947 |
| CSNK2A1 | -10604 | -10586 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| AAAS | -4744.0 | 12385 |
| AACS | 1343.0 | -6189 |
| AADAT | 10672.0 | 7274 |
| AANAT | 12010.0 | -5836 |
| AASDHPPT | -7781.0 | -4901 |
| AASS | -2035.0 | -7338 |
| ABCA1 | -7160.0 | -10627 |
| ABCB1 | 9940.0 | -4711 |
| ABCB11 | 2944.0 | -1218 |
| ABCB4 | 12709.0 | -8356 |
| ABCB7 | 8692.0 | -10036 |
| ABCC1 | -10345.0 | -8280 |
| ABCC2 | 4733.0 | 6426 |
| ABCC3 | 12499.0 | 10837 |
| ABCC5 | 9428.0 | 10051 |
| ABCC8 | 7897.0 | 5217 |
| ABCD1 | 9287.0 | 8795 |
| ABCD4 | 10878.0 | 12148 |
| ABCG2 | 2336.0 | -3473 |
| ABHD10 | -11231.0 | -4814 |
| ABHD14B | 11952.0 | 9001 |
| ABHD3 | 3550.0 | 11200 |
| ABHD4 | -4078.0 | -7842 |
| ABHD5 | 1064.0 | -6657 |
| ABO | -4213.0 | 5177 |
| ACAA1 | -4953.0 | 11750 |
| ACAA2 | 10396.0 | -7152 |
| ACACA | 11587.0 | -9231 |
| ACACB | 10941.0 | 6062 |
| ACAD10 | -4682.0 | 5611 |
| ACAD11 | 11686.0 | 11919 |
| ACAD8 | 11347.0 | 11473 |
| ACAD9 | 12457.0 | 11377 |
| ACADL | 8538.0 | 8414 |
| ACADM | 11816.0 | -7756 |
| ACADS | 6860.0 | 2972 |
| ACADSB | 8386.0 | 4523 |
| ACADVL | 2389.0 | 12145 |
| ACAN | -11431.0 | -5454 |
| ACAT1 | -10638.0 | -4238 |
| ACAT2 | -10960.0 | 7414 |
| ACBD4 | 11086.0 | 8493 |
| ACBD5 | -8935.0 | -9274 |
| ACBD6 | 9618.0 | 7732 |
| ACBD7 | 7658.0 | 10413 |
| ACER2 | -5135.0 | -4867 |
| ACER3 | 12167.0 | -10968 |
| ACHE | 9948.0 | -44 |
| ACLY | -5483.0 | -10039 |
| ACO2 | -5040.0 | -2386 |
| ACOT1 | 7027.0 | 8597 |
| ACOT11 | 12014.0 | 10401 |
| ACOT13 | 1622.0 | 13024 |
| ACOT2 | 11129.0 | 10447 |
| ACOT4 | -4555.0 | 260 |
| ACOT7 | 1170.0 | -5089 |
| ACOT8 | 7723.0 | 8533 |
| ACOT9 | -1195.0 | 9258 |
| ACOX1 | 7261.0 | -7982 |
| ACOX2 | -7996.0 | -2272 |
| ACOX3 | -6026.0 | -7034 |
| ACOXL | 7706.0 | 6794 |
| ACP5 | 2052.0 | 4569 |
| ACP6 | 12363.0 | -5186 |
| ACSBG1 | 6454.0 | -166 |
| ACSBG2 | 2129.0 | -1265 |
| ACSF2 | 11490.0 | 7592 |
| ACSF3 | 10362.0 | -4143 |
| ACSL1 | -10761.0 | -9001 |
| ACSL3 | -8531.0 | -10470 |
| ACSL4 | 7111.0 | -10248 |
| ACSL5 | 10146.0 | 3509 |
| ACSL6 | 3266.0 | 320 |
| ACSM2A | 702.0 | 5396 |
| ACSM2B | 4526.0 | 6365 |
| ACSM3 | -3701.0 | 1817 |
| ACSS1 | 9723.0 | -5086 |
| ACSS2 | -11053.0 | 7142 |
| ACSS3 | 12795.0 | -3663 |
| ACY1 | 12101.0 | 10851 |
| ACY3 | -2691.0 | 7876 |
| ADA | -8806.0 | -8858 |
| ADAL | 11415.0 | 3650 |
| ADCY1 | 11934.0 | -11008 |
| ADCY2 | -11203.0 | -2904 |
| ADCY3 | -9214.0 | -7503 |
| ADCY4 | 2183.0 | -585 |
| ADCY5 | 11160.0 | -6292 |
| ADCY6 | 12249.0 | -10841 |
| ADCY7 | -11317.0 | -10422 |
| ADCY9 | -7412.0 | -9235 |
| ADH1B | -1410.0 | 7572 |
| ADH5 | -9602.0 | 5293 |
| ADH6 | 4290.0 | 3108 |
| ADHFE1 | 5031.0 | 7843 |
| ADI1 | -3579.0 | 9094 |
| ADIPOQ | 2279.0 | 1680 |
| ADIPOR1 | 981.0 | -7013 |
| ADIPOR2 | -7270.0 | -9992 |
| ADK | -8711.0 | -5126 |
| ADO | 6777.0 | -9156 |
| ADPGK | 10229.0 | 10700 |
| ADPRM | -10668.0 | -2606 |
| ADRA2A | 3627.0 | -8577 |
| ADSL | -7101.0 | 5099 |
| AFMID | -4671.0 | 7924 |
| AGK | 12316.0 | 10534 |
| AGL | 11480.0 | -6654 |
| AGMAT | 994.0 | 328 |
| AGPAT1 | 12340.0 | -8581 |
| AGPAT2 | -7585.0 | 10548 |
| AGPAT3 | -10865.0 | -9124 |
| AGPAT4 | -11056.0 | 9424 |
| AGPAT5 | -11194.0 | -8876 |
| AGPS | 10100.0 | -8255 |
| AGRN | 12518.0 | -11205 |
| AGT | -896.0 | 9184 |
| AHCY | 1345.0 | 629 |
| AHCYL1 | 5721.0 | -10813 |
| AHR | 11532.0 | -9559 |
| AHRR | -3732.0 | -4926 |
| AIMP1 | -9006.0 | 1838 |
| AIMP2 | 1872.0 | -2032 |
| AIP | -9180.0 | 11847 |
| AK1 | 11507.0 | 11648 |
| AK2 | 10568.0 | 11770 |
| AK4 | 12687.0 | -9278 |
| AK5 | -11006.0 | -4602 |
| AK6 | -5056.0 | 2163 |
| AK7 | 8247.0 | -25 |
| AK8 | 5270.0 | 5210 |
| AK9 | 9223.0 | 4775 |
| AKAP5 | 6930.0 | 2937 |
| AKR1A1 | -7653.0 | -1413 |
| AKR1B1 | 12462.0 | 9788 |
| AKR1B15 | -3729.0 | 2493 |
| AKR1C1 | -10089.0 | 6360 |
| AKR1C3 | -11277.0 | 12190 |
| AKR1D1 | 4199.0 | -863 |
| AKR7A2 | -7562.0 | -6933 |
| AKR7A3 | -2562.0 | 9849 |
| AKR7L | 4465.0 | 9366 |
| AKT1 | -1733.0 | -1215 |
| ALAD | 11487.0 | 10437 |
| ALAS1 | 4171.0 | -10735 |
| ALB | 5080.0 | 7354 |
| ALDH18A1 | -8886.0 | -10473 |
| ALDH1B1 | 3049.0 | -5217 |
| ALDH1L1 | 10726.0 | -4687 |
| ALDH1L2 | -9706.0 | -2755 |
| ALDH2 | 8098.0 | 10715 |
| ALDH3A2 | 5431.0 | -5930 |
| ALDH3B1 | 4355.0 | 5738 |
| ALDH4A1 | 11146.0 | -3790 |
| ALDH6A1 | -7224.0 | -8331 |
| ALDH7A1 | 10593.0 | 11100 |
| ALDH9A1 | -560.0 | -6258 |
| ALDOA | -10796.0 | -4574 |
| ALDOB | 2760.0 | -1433 |
| ALDOC | -6280.0 | -10161 |
| ALOX12 | 7011.0 | -3915 |
| ALOX12B | 8729.0 | 8897 |
| ALOX15 | 5469.0 | 486 |
| ALOX5 | -4106.0 | 3491 |
| ALOXE3 | -5635.0 | -79 |
| AMACR | -9836.0 | -5719 |
| AMD1 | -9021.0 | -9915 |
| AMDHD1 | 11155.0 | 6105 |
| AMN | -10167.0 | 7581 |
| AMPD2 | -4481.0 | -8931 |
| AMPD3 | 12832.0 | -9484 |
| AMT | 6745.0 | 8913 |
| ANGPTL4 | 12903.0 | -6065 |
| AOC1 | 8076.0 | 6605 |
| AOC2 | -9694.0 | -4120 |
| AOC3 | -9102.0 | -649 |
| AOX1 | -8757.0 | 980 |
| APIP | -5270.0 | 9958 |
| APOA1 | -726.0 | 8518 |
| APOC2 | -135.0 | 3265 |
| APOE | 12058.0 | 12721 |
| APOM | 1204.0 | 8569 |
| APRT | 9297.0 | 12493 |
| ARF1 | -9163.0 | -5561 |
| ARF3 | 3251.0 | -6648 |
| ARG1 | 1715.0 | -1184 |
| ARG2 | -11492.0 | -11033 |
| ARNT | -9141.0 | -10063 |
| ARNT2 | 12715.0 | -11191 |
| ARNTL | -4487.0 | -3271 |
| ARSA | 11743.0 | 9589 |
| ARSB | 12086.0 | -7494 |
| ARSD | 9745.0 | -6384 |
| ARSG | 12508.0 | -4208 |
| ARSI | -7529.0 | -4701 |
| ARSJ | -8413.0 | -8593 |
| ARSK | -2824.0 | -7149 |
| ARV1 | 2587.0 | 12259 |
| AS3MT | -2790.0 | 5436 |
| ASAH1 | -3293.0 | 6434 |
| ASAH2 | 1536.0 | -4922 |
| ASL | 12501.0 | 5148 |
| ASNS | -10878.0 | 12349 |
| ASPA | 5403.0 | 1602 |
| ASRGL1 | 9236.0 | 582 |
| ASS1 | 11521.0 | -1872 |
| ATIC | -10939.0 | 1689 |
| ATP5F1A | 7998.0 | -9624 |
| ATP5F1B | -8379.0 | -9015 |
| ATP5F1C | -287.0 | 12518 |
| ATP5F1D | -1232.0 | 12979 |
| ATP5F1E | -1539.0 | 10947 |
| ATP5MC1 | 10755.0 | 12985 |
| ATP5MC2 | -3774.0 | 12406 |
| ATP5MC3 | 2759.0 | 11175 |
| ATP5ME | -5746.0 | 13136 |
| ATP5MF | -8135.0 | 13076 |
| ATP5MG | -6440.0 | 13061 |
| ATP5PB | 6563.0 | -5803 |
| ATP5PD | -3802.0 | 13152 |
| ATP5PF | -6437.0 | 12713 |
| ATP5PO | -8733.0 | 12858 |
| AUH | 5719.0 | 5062 |
| AZIN1 | -8879.0 | -10550 |
| AZIN2 | 3795.0 | 3688 |
| B3GALNT1 | 12351.0 | -7110 |
| B3GALT1 | -3499.0 | -5100 |
| B3GALT4 | 10271.0 | -5354 |
| B3GALT5 | 12085.0 | -9244 |
| B3GALT6 | 11393.0 | 11355 |
| B3GAT1 | -914.0 | 2011 |
| B3GAT2 | -4097.0 | 5251 |
| B3GAT3 | 11784.0 | 9103 |
| B3GNT2 | -4449.0 | -8797 |
| B3GNT3 | 8484.0 | -3659 |
| B3GNT4 | -4093.0 | -76 |
| B3GNT7 | 11985.0 | -6668 |
| B4GALNT1 | 11773.0 | 7801 |
| B4GALNT2 | -2329.0 | -6986 |
| B4GALT1 | -11375.0 | -10725 |
| B4GALT2 | -10045.0 | -4360 |
| B4GALT3 | -6120.0 | -9469 |
| B4GALT4 | -4406.0 | -8129 |
| B4GALT5 | 12672.0 | -9776 |
| B4GALT6 | -8212.0 | -9561 |
| B4GALT7 | 10562.0 | -4980 |
| B4GAT1 | 7603.0 | 7600 |
| BAAT | -3113.0 | 5632 |
| BCAN | 12079.0 | -4013 |
| BCAT1 | -7644.0 | -9371 |
| BCAT2 | -6548.0 | 8118 |
| BCHE | 7338.0 | 10241 |
| BCKDHA | 8458.0 | -10040 |
| BCKDHB | 10575.0 | 160 |
| BCKDK | -4165.0 | -6907 |
| BCO2 | 4100.0 | 9439 |
| BDH1 | -7821.0 | 12097 |
| BDH2 | -5261.0 | 12093 |
| BGN | 11953.0 | -1313 |
| BHMT | -547.0 | 5797 |
| BHMT2 | 12451.0 | 10224 |
| BLVRA | -1722.0 | 9856 |
| BLVRB | -8667.0 | 9403 |
| BPGM | -11529.0 | 1553 |
| BPHL | -1802.0 | 10633 |
| BPNT1 | 10007.0 | -6778 |
| BPNT2 | 9128.0 | -9980 |
| BRIP1 | 9999.0 | 3512 |
| BSG | -5149.0 | 12544 |
| BST1 | 9555.0 | -682 |
| BTD | 11562.0 | -8185 |
| CA12 | 12397.0 | -8847 |
| CA13 | 9451.0 | 6402 |
| CA14 | -8161.0 | -4804 |
| CA2 | 9840.0 | -10284 |
| CA3 | -4535.0 | 8190 |
| CA5B | -8990.0 | -60 |
| CA6 | 809.0 | 2201 |
| CA7 | -733.0 | 324 |
| CA9 | -11518.0 | -7389 |
| CACNA1A | 8256.0 | 12696 |
| CACNA1C | 11357.0 | -4385 |
| CACNA1D | 12251.0 | 7919 |
| CACNA1E | 1707.0 | 1168 |
| CACNA2D2 | 12046.0 | 3482 |
| CACNB2 | -2901.0 | 9935 |
| CACNB3 | -10750.0 | 131 |
| CAD | -7984.0 | -10810 |
| CALM1 | 11329.0 | -6948 |
| CARM1 | -11211.0 | -7070 |
| CARNMT1 | -7382.0 | -7203 |
| CARNS1 | 6990.0 | 326 |
| CAV1 | 12654.0 | -11158 |
| CBR1 | -9199.0 | 5166 |
| CBR3 | -7426.0 | 11814 |
| CBR4 | -8792.0 | -3500 |
| CBS | 10907.0 | 11159 |
| CBSL | -586.0 | 5098 |
| CCNC | -7228.0 | -7436 |
| CD320 | -6362.0 | 6079 |
| CD36 | -737.0 | 1067 |
| CD38 | -1924.0 | 1956 |
| CD44 | 7044.0 | -9772 |
| CDA | -2029.0 | 4632 |
| CDIPT | -8739.0 | -6855 |
| CDK19 | -7762.0 | -7499 |
| CDK8 | -8031.0 | -9098 |
| CDS1 | -5536.0 | -2686 |
| CDS2 | 12495.0 | -9650 |
| CEMIP | 12862.0 | -11284 |
| CEPT1 | -2571.0 | -8803 |
| CERK | -8014.0 | -8517 |
| CERS1 | -1196.0 | 6704 |
| CERS2 | -7338.0 | -10854 |
| CERS4 | -7329.0 | -3137 |
| CERS5 | -9908.0 | 8789 |
| CERS6 | -8252.0 | -10900 |
| CERT1 | -6444.0 | -10761 |
| CES1 | -9352.0 | 13087 |
| CES2 | -1532.0 | -9855 |
| CES3 | -2550.0 | 8219 |
| CGA | 4785.0 | 2191 |
| CH25H | 5534.0 | 10857 |
| CHAC1 | 9833.0 | 11307 |
| CHAC2 | -3772.0 | 7542 |
| CHAT | 6776.0 | -3180 |
| CHD9 | 6368.0 | -9728 |
| CHDH | 12135.0 | 8784 |
| CHKA | -9195.0 | 12581 |
| CHKB | 11206.0 | 12778 |
| CHP1 | 10834.0 | -7861 |
| CHPF | -11347.0 | -6066 |
| CHPF2 | 12137.0 | 9414 |
| CHPT1 | -2663.0 | -5035 |
| CHRM3 | 12228.0 | -6966 |
| CHST1 | 12515.0 | -9456 |
| CHST11 | 12103.0 | -10187 |
| CHST12 | 11011.0 | 10555 |
| CHST13 | 11177.0 | 9777 |
| CHST14 | 12268.0 | 10719 |
| CHST15 | 12906.0 | -11169 |
| CHST2 | -8741.0 | -7886 |
| CHST3 | -2862.0 | -10133 |
| CHST5 | 3375.0 | 6783 |
| CHST6 | -4221.0 | -9474 |
| CHST7 | -2403.0 | -5448 |
| CHST9 | 11110.0 | -1231 |
| CHSY1 | 3107.0 | -10988 |
| CHSY3 | 10102.0 | -9769 |
| CIAO1 | -9220.0 | 10231 |
| CIAO2B | -5392.0 | 12629 |
| CIAO3 | 803.0 | 11737 |
| CIAPIN1 | -2606.0 | -6542 |
| CKB | 11133.0 | 11188 |
| CKM | -2654.0 | 386 |
| CKMT1A | 10958.0 | 11903 |
| CKMT2 | 4895.0 | -1910 |
| CLOCK | -5145.0 | -9846 |
| CMBL | -11475.0 | 5764 |
| CMPK1 | -7140.0 | -8337 |
| CNDP2 | -10063.0 | -7916 |
| COA1 | 11438.0 | 12298 |
| COASY | 10855.0 | -4259 |
| COMT | -5537.0 | 11566 |
| COQ10A | 2060.0 | 8793 |
| COQ10B | -11071.0 | 1561 |
| COQ2 | 2965.0 | 10768 |
| COQ3 | 5953.0 | 9975 |
| COQ5 | 10096.0 | 9326 |
| COQ6 | 8027.0 | 12109 |
| COQ7 | -5430.0 | 7314 |
| COQ9 | -6427.0 | 10908 |
| COX10 | -10597.0 | -6894 |
| COX11 | 3872.0 | -3998 |
| COX14 | -5296.0 | 7054 |
| COX15 | 9353.0 | -9310 |
| COX16 | -4741.0 | 10348 |
| COX18 | -7574.0 | -2747 |
| COX19 | 5255.0 | 5188 |
| COX20 | -9184.0 | 10961 |
| COX4I1 | -1716.0 | 13016 |
| COX5A | 8620.0 | 10682 |
| COX5B | -6531.0 | 13149 |
| COX6A1 | -1616.0 | 13101 |
| COX6B1 | -9124.0 | 13132 |
| COX6C | 5468.0 | 12965 |
| COX7A2L | -5446.0 | -8229 |
| COX7B | -7400.0 | 13161 |
| COX7C | 9483.0 | 12599 |
| COX8A | -7227.0 | 12756 |
| CPNE1 | -7557.0 | 11964 |
| CPNE3 | -9909.0 | -10952 |
| CPNE7 | 217.0 | 12014 |
| CPOX | -9861.0 | -9061 |
| CPS1 | -10630.0 | 6101 |
| CPT1A | 7772.0 | -7257 |
| CPT1B | -5952.0 | 13011 |
| CPT2 | 9375.0 | -9508 |
| CPTP | 11350.0 | 10040 |
| CRAT | -7625.0 | -9868 |
| CREBBP | -10387.0 | -10534 |
| CRLS1 | -9065.0 | -3075 |
| CROT | 6611.0 | 7925 |
| CRYL1 | -10609.0 | -10098 |
| CRYM | -7062.0 | 2482 |
| CS | -9273.0 | -10545 |
| CSAD | -3233.0 | 12728 |
| CSGALNACT1 | -750.0 | -2738 |
| CSGALNACT2 | -10808.0 | -10564 |
| CSNK1G2 | -9423.0 | 5261 |
| CSNK2A1 | -10604.0 | -10586 |
| CSNK2A2 | -9949.0 | -10332 |
| CSNK2B | -9249.0 | 12011 |
| CSPG4 | 12459.0 | -11273 |
| CSPG5 | 545.0 | -3163 |
| CTH | -3063.0 | -3718 |
| CTPS1 | -3376.0 | 4124 |
| CTPS2 | -10393.0 | -6489 |
| CTRB2 | -6012.0 | 4160 |
| CTRC | 1947.0 | 4683 |
| CTSA | 10901.0 | -5855 |
| CUBN | 10733.0 | 10862 |
| CYB5A | 6459.0 | 10683 |
| CYB5B | 11510.0 | 10893 |
| CYB5R3 | -9040.0 | -4520 |
| CYC1 | -8796.0 | 9550 |
| CYCS | -2044.0 | 10884 |
| CYGB | 12888.0 | 11069 |
| CYP11A1 | 12765.0 | -8287 |
| CYP19A1 | -1032.0 | 5862 |
| CYP1A1 | 3546.0 | 6045 |
| CYP1A2 | -2545.0 | 5313 |
| CYP1B1 | -10765.0 | -5640 |
| CYP21A2 | -92.0 | 3335 |
| CYP24A1 | -4338.0 | -5656 |
| CYP26A1 | 8741.0 | 7820 |
| CYP26B1 | 12128.0 | 10216 |
| CYP26C1 | 8826.0 | -2625 |
| CYP27A1 | -8230.0 | 1966 |
| CYP27B1 | 9511.0 | -5684 |
| CYP2B6 | -3052.0 | 3621 |
| CYP2D6 | -989.0 | 9119 |
| CYP2E1 | -6219.0 | 8331 |
| CYP2J2 | 4429.0 | 9256 |
| CYP2R1 | 9448.0 | 4633 |
| CYP2S1 | 8226.0 | -4599 |
| CYP2U1 | 8853.0 | -5648 |
| CYP2W1 | 4249.0 | -1602 |
| CYP39A1 | 5329.0 | 5740 |
| CYP3A43 | 5593.0 | -2743 |
| CYP3A5 | 2707.0 | 6208 |
| CYP46A1 | 7453.0 | 5231 |
| CYP4F8 | 6270.0 | -66 |
| CYP4V2 | 5818.0 | 864 |
| CYP51A1 | -11252.0 | -9071 |
| CYP7B1 | 5761.0 | -461 |
| CYP8B1 | -3521.0 | 3106 |
| D2HGDH | 8528.0 | 8058 |
| DARS1 | -10008.0 | 4483 |
| DBH | 9900.0 | -1549 |
| DBI | 8149.0 | 12345 |
| DBT | -3782.0 | -8648 |
| DCK | -10198.0 | -7845 |
| DCT | -3537.0 | 2001 |
| DCTD | -9375.0 | -9046 |
| DCTPP1 | -8574.0 | -6485 |
| DCXR | -6370.0 | 12401 |
| DDAH1 | -6964.0 | -7600 |
| DDAH2 | -9500.0 | 5750 |
| DDHD1 | -8454.0 | -9590 |
| DDHD2 | -11261.0 | -9027 |
| DDO | 2059.0 | -137 |
| DECR1 | -3511.0 | 12026 |
| DECR2 | -7829.0 | 12111 |
| DEGS1 | 6912.0 | 7355 |
| DEGS2 | 11394.0 | -1323 |
| DERA | 9303.0 | 2736 |
| DGAT1 | -3372.0 | 10410 |
| DGAT2 | -10973.0 | 9278 |
| DGUOK | 6144.0 | 12677 |
| DHCR24 | 10141.0 | -5101 |
| DHCR7 | -10620.0 | -4740 |
| DHFR | 12668.0 | 12586 |
| DHFR2 | 782.0 | -5739 |
| DHODH | 7360.0 | 10538 |
| DHRS7B | -1339.0 | 12357 |
| DHTKD1 | -1810.0 | -8372 |
| DIO2 | -8254.0 | 8806 |
| DLAT | -8123.0 | -7745 |
| DLD | -9253.0 | -8294 |
| DLST | -8194.0 | -10831 |
| DMAC2L | 10867.0 | 2617 |
| DMGDH | 9315.0 | 3116 |
| DNM2 | -8486.0 | -5605 |
| DNPH1 | 10105.0 | 11763 |
| DPYD | 8870.0 | -5791 |
| DSE | -8555.0 | -10893 |
| DSEL | -10343.0 | -356 |
| DTYMK | -8134.0 | 8022 |
| DUOX1 | 6936.0 | -3160 |
| DUOX2 | 1184.0 | -269 |
| DUT | 12336.0 | 10849 |
| EBP | -10085.0 | 10557 |
| ECHS1 | -11411.0 | 11233 |
| ECI1 | 2788.0 | 11866 |
| ECI2 | -9692.0 | -6771 |
| ECSIT | -6333.0 | 10114 |
| EEF1E1 | -10204.0 | 1084 |
| EEFSEC | 11184.0 | -3492 |
| EHHADH | 8480.0 | -8982 |
| ELOVL1 | -11072.0 | -7190 |
| ELOVL2 | 10313.0 | -2466 |
| ELOVL4 | -6472.0 | -6336 |
| ELOVL5 | -8932.0 | -9605 |
| ELOVL6 | 11756.0 | -4557 |
| ELOVL7 | 7136.0 | -6795 |
| ENO1 | 10742.0 | -9306 |
| ENO2 | -4344.0 | -7769 |
| ENO3 | -4079.0 | 11501 |
| ENOPH1 | -10785.0 | 1785 |
| ENPP1 | -6596.0 | -3337 |
| ENPP2 | 8991.0 | 2009 |
| ENPP3 | 2888.0 | 572 |
| ENPP6 | -380.0 | 4251 |
| ENTPD1 | 5547.0 | -4297 |
| ENTPD3 | -11180.0 | -5340 |
| ENTPD4 | -10501.0 | 10554 |
| ENTPD5 | 10176.0 | 1379 |
| ENTPD6 | 2650.0 | 4900 |
| ENTPD7 | -7652.0 | -8631 |
| ENTPD8 | 7530.0 | 10033 |
| EP300 | -9471.0 | -10672 |
| EPHX1 | 6496.0 | 11259 |
| EPHX2 | -4451.0 | 4247 |
| EPM2A | -7152.0 | 2522 |
| EPRS1 | 1368.0 | -10895 |
| ERCC2 | -6434.0 | -1786 |
| ESD | -6134.0 | -4610 |
| ESRRA | -11153.0 | 10724 |
| ESYT1 | 8647.0 | -10938 |
| ESYT2 | 12481.0 | -11207 |
| ESYT3 | 9721.0 | 10425 |
| ETFA | -3727.0 | -7917 |
| ETFB | -10912.0 | 576 |
| ETFDH | 2376.0 | 356 |
| ETHE1 | -10431.0 | -6139 |
| ETNK1 | -6875.0 | -4750 |
| ETNK2 | 4136.0 | -8591 |
| EXT1 | 10114.0 | -6275 |
| EXT2 | 11023.0 | -9224 |
| FA2H | 1994.0 | 1273 |
| FAAH | -5690.0 | 7992 |
| FABP2 | 126.0 | 2676 |
| FABP3 | -8553.0 | -4361 |
| FABP5 | 11205.0 | 13058 |
| FABP6 | -3377.0 | 8934 |
| FADS1 | 12050.0 | -9601 |
| FADS2 | 12638.0 | -6478 |
| FAH | -6674.0 | 8819 |
| FAHD1 | -6287.0 | 7691 |
| FAM120B | 7228.0 | -7376 |
| FAR1 | -4963.0 | -4058 |
| FAR2 | 7416.0 | -5720 |
| FASN | -8601.0 | -9423 |
| FAU | -8610.0 | 13102 |
| FBP2 | -4228.0 | 1232 |
| FDFT1 | -11448.0 | -6461 |
| FDPS | -3650.0 | 10686 |
| FDX1 | -8625.0 | 8318 |
| FDX2 | -5678.0 | 10706 |
| FDXR | 6797.0 | -10 |
| FECH | 11383.0 | -7205 |
| FH | -396.0 | 11082 |
| FHL2 | 10766.0 | -7877 |
| FIG4 | 10135.0 | -5525 |
| FITM1 | 5543.0 | -1203 |
| FITM2 | 10202.0 | -8826 |
| FLAD1 | 2160.0 | 10392 |
| FLVCR1 | 3233.0 | 10 |
| FOLH1 | -7523.0 | 445 |
| FPGS | 10956.0 | -4324 |
| FTCD | 6855.0 | 10549 |
| FUT1 | 10043.0 | -4555 |
| FUT10 | -10213.0 | -7031 |
| FUT11 | 6493.0 | -8752 |
| FUT2 | 8078.0 | 4687 |
| FUT3 | -8103.0 | 4300 |
| FUT4 | -11103.0 | -9194 |
| FUT6 | 5815.0 | -592 |
| FXN | 3001.0 | 6244 |
| G0S2 | 8280.0 | 10459 |
| G6PC3 | 11270.0 | 11945 |
| G6PD | -6770.0 | -3541 |
| GAA | 12540.0 | -6361 |
| GADL1 | -795.0 | -1006 |
| GALC | 11711.0 | -7970 |
| GALE | 12776.0 | 12817 |
| GALK1 | -8218.0 | -4824 |
| GALT | 3911.0 | 10632 |
| GAMT | 11210.0 | 12230 |
| GAPDH | 8544.0 | -4543 |
| GART | -10887.0 | -9545 |
| GATM | 11947.0 | -7095 |
| GBA | 12033.0 | 4321 |
| GBA2 | 10853.0 | 9195 |
| GBA3 | 4649.0 | -1483 |
| GBE1 | 12790.0 | -10994 |
| GCAT | -10028.0 | 11163 |
| GCDH | 6035.0 | 9903 |
| GCH1 | 9093.0 | -6765 |
| GCHFR | 12894.0 | -5193 |
| GCK | -1708.0 | 4592 |
| GCKR | 2962.0 | -1183 |
| GCLC | -7629.0 | -8062 |
| GCLM | -8232.0 | -8455 |
| GCSH | -6761.0 | 9913 |
| GDA | -2617.0 | -773 |
| GDE1 | -5489.0 | -5600 |
| GDPD1 | 6538.0 | -5821 |
| GDPD3 | -8814.0 | 10429 |
| GDPD5 | -5058.0 | -4242 |
| GGCT | 9631.0 | 8227 |
| GGPS1 | -5726.0 | -75 |
| GGT1 | 9086.0 | 9992 |
| GGT5 | -4069.0 | 9731 |
| GGT6 | 3650.0 | 393 |
| GGT7 | 9413.0 | 7557 |
| GK | -11506.0 | -277 |
| GLA | -4035.0 | 12059 |
| GLB1 | 10162.0 | -9240 |
| GLB1L | 10787.0 | 1974 |
| GLCE | -9839.0 | -7514 |
| GLDC | 4017.0 | -7420 |
| GLIPR1 | -11095.0 | 12768 |
| GLO1 | -8377.0 | 4629 |
| GLP1R | 9005.0 | -2527 |
| GLRX | 12806.0 | -339 |
| GLRX5 | -9519.0 | 11726 |
| GLS | -9356.0 | -8809 |
| GLS2 | 9366.0 | 2679 |
| GLTP | 294.0 | -3070 |
| GLUD1 | -9514.0 | -10318 |
| GLUD2 | -5197.0 | -4510 |
| GLUL | 12531.0 | -9935 |
| GLYATL1 | 3821.0 | 802 |
| GLYATL2 | -1029.0 | 1059 |
| GLYCTK | 11002.0 | 8529 |
| GM2A | 11293.0 | -4391 |
| GMPR | 11243.0 | 9305 |
| GMPR2 | 9392.0 | -3933 |
| GMPS | -4389.0 | -7492 |
| GNA11 | -7494.0 | -9222 |
| GNA14 | 2396.0 | -1461 |
| GNA15 | 4887.0 | -1938 |
| GNAI1 | -9053.0 | -9191 |
| GNAI2 | -3839.0 | -3626 |
| GNAQ | -5653.0 | -8840 |
| GNAS | 8799.0 | 12628 |
| GNB1 | -8510.0 | -10750 |
| GNB2 | -10836.0 | -7224 |
| GNB3 | -5251.0 | 10539 |
| GNB4 | -6880.0 | -9745 |
| GNB5 | 9864.0 | -5736 |
| GNG10 | -2116.0 | 6341 |
| GNG11 | -11165.0 | 11584 |
| GNG12 | -8091.0 | -10696 |
| GNG2 | -9822.0 | -5394 |
| GNG4 | 12509.0 | 262 |
| GNG5 | -2592.0 | 10603 |
| GNG7 | 10314.0 | 5271 |
| GNGT2 | 8291.0 | 1587 |
| GNMT | -1375.0 | 5139 |
| GNPAT | -3027.0 | 5570 |
| GNPDA1 | -9604.0 | -8425 |
| GNPDA2 | -8436.0 | -4994 |
| GNS | 11099.0 | -11125 |
| GOT1 | -251.0 | 7784 |
| GOT2 | 11173.0 | 841 |
| GPAM | 9347.0 | -8178 |
| GPAT2 | -3610.0 | 6349 |
| GPAT3 | -3147.0 | -8656 |
| GPAT4 | -9453.0 | -6583 |
| GPC1 | 1951.0 | -7922 |
| GPC2 | -3913.0 | -3279 |
| GPC4 | 11190.0 | -8942 |
| GPC5 | 7673.0 | -3135 |
| GPC6 | -6095.0 | -11229 |
| GPCPD1 | -11362.0 | 12472 |
| GPD1 | 1.0 | 6256 |
| GPD1L | -393.0 | 5259 |
| GPD2 | 8694.0 | -9821 |
| GPHN | -1949.0 | -10361 |
| GPI | -9581.0 | -7088 |
| GPS2 | -7300.0 | 12877 |
| GPT | 8865.0 | 9142 |
| GPT2 | 8365.0 | 7519 |
| GPX1 | 7862.0 | 12387 |
| GPX2 | 2218.0 | 3022 |
| GPX4 | -10566.0 | 12566 |
| GRHL1 | 9277.0 | -206 |
| GRHPR | -6215.0 | 8320 |
| GSR | -11433.0 | -4996 |
| GSS | 11218.0 | 9939 |
| GSTA4 | -6690.0 | -1181 |
| GSTK1 | 12523.0 | 11152 |
| GSTM1 | 6083.0 | 8492 |
| GSTM2 | 1645.0 | 10470 |
| GSTM3 | -7719.0 | 8050 |
| GSTM4 | 10485.0 | 9146 |
| GSTO1 | -8782.0 | 12837 |
| GSTO2 | 1449.0 | 4256 |
| GSTP1 | -9254.0 | 12602 |
| GSTT2 | -2234.0 | 3992 |
| GSTT2B | 9459.0 | 11851 |
| GSTZ1 | 10777.0 | 8707 |
| GUK1 | -9476.0 | 10188 |
| GUSB | 9430.0 | 8910 |
| GYG1 | 10629.0 | -8829 |
| GYG2 | 10117.0 | -1505 |
| GYS1 | -8713.0 | -8373 |
| HAAO | 8688.0 | 9133 |
| HACD1 | 5363.0 | 1605 |
| HACD2 | -4771.0 | -8602 |
| HACD3 | 9333.0 | -10814 |
| HACD4 | 2499.0 | 4283 |
| HACL1 | 9746.0 | -6929 |
| HADH | -9269.0 | 10963 |
| HADHA | 10596.0 | -8030 |
| HADHB | -424.0 | -8570 |
| HAGH | 10014.0 | 11571 |
| HAL | -3269.0 | 4475 |
| HAS2 | -11561.0 | -9065 |
| HAS3 | 11539.0 | -8568 |
| HDAC3 | 10500.0 | -7476 |
| HELZ2 | 6737.0 | -11221 |
| HEXA | 12426.0 | 6143 |
| HEXB | 1770.0 | -1985 |
| HIBADH | 2089.0 | 8513 |
| HIBCH | -2666.0 | 969 |
| HILPDA | 12823.0 | -6351 |
| HK1 | 8176.0 | -10566 |
| HK2 | 5513.0 | -11103 |
| HLCS | 1981.0 | -7850 |
| HMBS | -6797.0 | 11970 |
| HMGCL | -5305.0 | -5204 |
| HMGCR | -9941.0 | -10570 |
| HMGCS1 | -10536.0 | -9535 |
| HMMR | 6132.0 | 1294 |
| HMOX1 | -11186.0 | -1600 |
| HMOX2 | -10454.0 | 1742 |
| HNMT | -1649.0 | 3699 |
| HOGA1 | 1298.0 | 5341 |
| HPD | 1912.0 | 5180 |
| HPGD | 6500.0 | 1008 |
| HPRT1 | 358.0 | -259 |
| HPSE | -6814.0 | -4898 |
| HS2ST1 | -858.0 | -10708 |
| HS3ST3A1 | -11441.0 | -8358 |
| HS3ST3B1 | -11527.0 | -10530 |
| HS3ST4 | 11403.0 | 4734 |
| HS3ST5 | 8627.0 | -3934 |
| HS3ST6 | -3230.0 | 6911 |
| HS6ST1 | -8821.0 | -6022 |
| HS6ST2 | 12471.0 | -6831 |
| HS6ST3 | -6685.0 | 5510 |
| HSCB | -10466.0 | 7562 |
| HSD11B1 | 11024.0 | -4770 |
| HSD11B2 | 5780.0 | 3705 |
| HSD17B1 | 3773.0 | 5477 |
| HSD17B10 | 2620.0 | 11931 |
| HSD17B11 | -9945.0 | -2869 |
| HSD17B12 | -8890.0 | -8865 |
| HSD17B13 | -317.0 | 7872 |
| HSD17B14 | 9553.0 | 9653 |
| HSD17B2 | -5849.0 | -5013 |
| HSD17B3 | 6008.0 | 9432 |
| HSD17B4 | 12326.0 | 883 |
| HSD17B7 | -7606.0 | 7172 |
| HSD17B8 | 6130.0 | -2864 |
| HSD3B1 | 1099.0 | -4781 |
| HSD3B2 | 561.0 | -4405 |
| HSD3B7 | -8631.0 | -5807 |
| HSP90AA1 | 11397.0 | -7534 |
| HSP90AB1 | -9168.0 | -9114 |
| HSPG2 | -9046.0 | -9768 |
| HTD2 | -3789.0 | -5185 |
| HYAL1 | 4794.0 | 556 |
| HYAL2 | 7029.0 | 10799 |
| HYAL3 | 429.0 | 9382 |
| HYKK | -4392.0 | 9854 |
| IARS1 | -2182.0 | -9570 |
| IDH1 | -8291.0 | -2632 |
| IDH2 | -11009.0 | -7176 |
| IDH3A | -8898.0 | -3067 |
| IDH3B | -4300.0 | -4551 |
| IDH3G | 117.0 | 9128 |
| IDI1 | -10047.0 | -6271 |
| IDO2 | 4265.0 | 2865 |
| IDS | 8178.0 | -10132 |
| IDUA | 11538.0 | 11620 |
| IL4I1 | -11099.0 | -4396 |
| IMPA1 | -5510.0 | -6525 |
| IMPA2 | -9466.0 | -8384 |
| IMPDH1 | -8676.0 | -5498 |
| IMPDH2 | -9060.0 | -9748 |
| INMT | 9444.0 | -4952 |
| INPP1 | 9905.0 | 3038 |
| INPP4A | -6949.0 | -8897 |
| INPP4B | 7799.0 | 1151 |
| INPP5A | -5057.0 | -8151 |
| INPP5B | 12347.0 | -6141 |
| INPP5D | 12494.0 | -6335 |
| INPP5E | -9231.0 | 9571 |
| INPP5F | -6267.0 | -8385 |
| INPP5J | 2774.0 | 6306 |
| INPP5K | -2145.0 | 5151 |
| INPPL1 | -7710.0 | -4327 |
| INSIG1 | -8247.0 | -10291 |
| INSIG2 | 7660.0 | -8487 |
| IP6K1 | -6152.0 | -6742 |
| IP6K2 | -2736.0 | 8348 |
| IPMK | -4650.0 | -8547 |
| IPPK | -7804.0 | 6703 |
| IQGAP1 | -11188.0 | -11226 |
| ISCA1 | -7587.0 | -4971 |
| ISCA2 | 2253.0 | 4958 |
| ISCU | -6298.0 | 10132 |
| ISYNA1 | -5583.0 | 12774 |
| ITPA | 5034.0 | 11916 |
| ITPK1 | -4577.0 | 11119 |
| ITPKA | -10540.0 | 2290 |
| ITPKB | 6953.0 | -9629 |
| ITPKC | -11063.0 | -7089 |
| ITPR1 | -11523.0 | -11275 |
| ITPR2 | -7642.0 | -10382 |
| ITPR3 | 969.0 | -10878 |
| IVD | 12121.0 | -4420 |
| IYD | -351.0 | 5080 |
| KARS1 | -10243.0 | 9778 |
| KCNB1 | 6281.0 | 6918 |
| KCNG2 | 7474.0 | 2092 |
| KCNJ11 | -6079.0 | -3756 |
| KCNS3 | 9811.0 | -6261 |
| KDSR | -10284.0 | -10628 |
| KHK | 6482.0 | -1164 |
| KMO | 7390.0 | 6829 |
| KPNB1 | 6085.0 | -9326 |
| KYAT1 | -5720.0 | 2274 |
| KYAT3 | 10416.0 | -9152 |
| KYNU | -2499.0 | 6757 |
| L2HGDH | 7092.0 | -9403 |
| LARS1 | -7999.0 | -5859 |
| LBR | 10617.0 | -8863 |
| LCLAT1 | -5766.0 | -9874 |
| LDHA | -4687.0 | -9205 |
| LDHAL6A | -1233.0 | 5274 |
| LDHAL6B | 5276.0 | -3235 |
| LDHB | 3274.0 | 2139 |
| LDLR | -1005.0 | -10920 |
| LGMN | -5791.0 | -7132 |
| LHB | 5241.0 | 1674 |
| LHPP | 11470.0 | 6527 |
| LIAS | -9105.0 | 5143 |
| LIPE | 8482.0 | 4384 |
| LIPH | 3458.0 | 5131 |
| LIPT1 | -8180.0 | 2538 |
| LIPT2 | -2271.0 | 5033 |
| LMBRD1 | -8193.0 | -7829 |
| LPCAT1 | -3028.0 | -5868 |
| LPCAT2 | -5840.0 | -6904 |
| LPCAT3 | 12306.0 | 8926 |
| LPCAT4 | -10814.0 | 11636 |
| LPGAT1 | 9789.0 | -9221 |
| LPIN1 | -10795.0 | -5721 |
| LPIN2 | 7561.0 | -11087 |
| LPIN3 | 3240.0 | 9122 |
| LPL | -11212.0 | -8638 |
| LRAT | 3496.0 | 3064 |
| LRP1 | 11313.0 | -10721 |
| LRP10 | 12875.0 | -11287 |
| LRP12 | -10595.0 | -11129 |
| LRP2 | 8899.0 | -2352 |
| LRP8 | 8189.0 | -9203 |
| LRPPRC | -7531.0 | -9086 |
| LSS | -6494.0 | -7687 |
| LTA4H | -9399.0 | -7128 |
| LYPLA1 | -3476.0 | -11176 |
| LYRM4 | -3448.0 | 10228 |
| MAN2B1 | 8035.0 | -9988 |
| MAN2B2 | 12075.0 | -5833 |
| MAN2C1 | 12005.0 | 11813 |
| MANBA | -10376.0 | 7010 |
| MAOA | -3391.0 | -5960 |
| MAOB | 6834.0 | 8909 |
| MAPKAPK2 | -3317.0 | -7911 |
| MARCKS | -3690.0 | -8784 |
| MARS1 | -1476.0 | 10979 |
| MAT1A | -6091.0 | 2828 |
| MAT2A | 12784.0 | -5987 |
| MAT2B | -6792.0 | -8563 |
| MBOAT1 | -7369.0 | -4354 |
| MBOAT2 | -9788.0 | -8124 |
| MBOAT7 | 4107.0 | -7700 |
| MBTPS1 | 12152.0 | -6413 |
| MBTPS2 | 6403.0 | -10090 |
| MCAT | -8937.0 | 4501 |
| MCCC1 | 12225.0 | -6790 |
| MCCC2 | 8284.0 | -1797 |
| MCEE | -6643.0 | -2102 |
| MDH1 | 10483.0 | 11132 |
| MDH2 | -10661.0 | -8768 |
| ME1 | 6821.0 | -7488 |
| ME2 | -10992.0 | -10086 |
| ME3 | -8506.0 | 7768 |
| MECR | 9196.0 | 4995 |
| MED1 | 4565.0 | -10954 |
| MED10 | -10647.0 | -1516 |
| MED11 | 4180.0 | 11924 |
| MED12 | 9393.0 | -7619 |
| MED13 | 4175.0 | -11032 |
| MED13L | -6849.0 | -10882 |
| MED14 | -9534.0 | -10023 |
| MED15 | -8873.0 | 1271 |
| MED16 | -208.0 | -5452 |
| MED17 | -8560.0 | -6232 |
| MED18 | -5111.0 | 7388 |
| MED19 | -8211.0 | 667 |
| MED20 | -7954.0 | -6157 |
| MED21 | -8801.0 | -5810 |
| MED22 | 11643.0 | -4252 |
| MED23 | 1919.0 | -8179 |
| MED24 | 11859.0 | -4035 |
| MED25 | -8951.0 | 9901 |
| MED26 | -9943.0 | -4811 |
| MED27 | -3930.0 | 5130 |
| MED28 | 11227.0 | 4963 |
| MED29 | -6262.0 | -3527 |
| MED30 | 1643.0 | 6767 |
| MED31 | -7376.0 | 12435 |
| MED4 | -701.0 | 7901 |
| MED6 | -5208.0 | 8573 |
| MED7 | 9232.0 | 10734 |
| MED8 | 775.0 | -6428 |
| MED9 | -9036.0 | 3469 |
| MFSD2A | -11012.0 | 3357 |
| MGLL | 12726.0 | -10604 |
| MGST1 | -2552.0 | 11591 |
| MGST2 | 12190.0 | 12958 |
| MGST3 | 7748.0 | 11703 |
| MID1IP1 | 8046.0 | -7581 |
| MIGA1 | -4880.0 | -10227 |
| MIGA2 | -8827.0 | 11729 |
| MINPP1 | 6106.0 | -7890 |
| MIOX | -1281.0 | 3564 |
| MLX | -6671.0 | 1703 |
| MLXIPL | -8313.0 | 11156 |
| MLYCD | 9540.0 | -2921 |
| MMAA | -10781.0 | -2769 |
| MMAB | 8184.0 | 11228 |
| MMACHC | 5568.0 | 9309 |
| MMADHC | -9569.0 | -8402 |
| MMS19 | 7089.0 | -7187 |
| MMUT | -8807.0 | -9656 |
| MOCOS | 12767.0 | -9173 |
| MOCS1 | 11325.0 | -1330 |
| MOCS2 | 10711.0 | 12705 |
| MOCS3 | 9294.0 | -2193 |
| MOGAT3 | -1059.0 | 4237 |
| MORC2 | -7120.0 | 6149 |
| MPC1 | -6561.0 | 11380 |
| MPC2 | -5160.0 | 7935 |
| MPST | -4372.0 | 12019 |
| MRI1 | -8262.0 | 9899 |
| MSMO1 | -10896.0 | -7985 |
| MT-ATP6 | 8420.0 | 13018 |
| MT-ATP8 | 9404.0 | 12604 |
| MT-CO1 | 9067.0 | 13178 |
| MT-CO2 | 8603.0 | 13180 |
| MT-CO3 | 8245.0 | 13176 |
| MT-CYB | 5991.0 | 13184 |
| MT-ND1 | 5209.0 | 13177 |
| MT-ND2 | -1457.0 | 13183 |
| MT-ND3 | 6571.0 | 13181 |
| MT-ND4 | 566.0 | 13174 |
| MT-ND5 | 4289.0 | 13012 |
| MT-ND6 | 4676.0 | 13045 |
| MTAP | 5134.0 | 6545 |
| MTARC1 | 8013.0 | 4260 |
| MTARC2 | 4356.0 | 7988 |
| MTF1 | -8718.0 | -10119 |
| MTHFD1 | -7182.0 | 10303 |
| MTHFD1L | -8578.0 | -8322 |
| MTHFD2 | -8994.0 | -7194 |
| MTHFD2L | -3480.0 | 9174 |
| MTHFR | -7668.0 | -6396 |
| MTHFS | 385.0 | 11563 |
| MTM1 | -4584.0 | -7808 |
| MTMR1 | 10448.0 | -7007 |
| MTMR10 | 9939.0 | -6395 |
| MTMR12 | -10618.0 | -11138 |
| MTMR14 | -5165.0 | 7975 |
| MTMR2 | -6094.0 | -9336 |
| MTMR3 | -7836.0 | -10186 |
| MTMR4 | -4934.0 | -8877 |
| MTMR6 | -5385.0 | -8925 |
| MTMR7 | -5015.0 | 4886 |
| MTMR9 | -9350.0 | -8112 |
| MTR | 92.0 | -9742 |
| MTRR | -8284.0 | -8513 |
| MVD | -8157.0 | -5861 |
| MVK | -6968.0 | 8489 |
| N6AMT1 | 7099.0 | 10581 |
| NAALAD2 | 7668.0 | 8036 |
| NADK | 8707.0 | 11437 |
| NADK2 | -7715.0 | -8326 |
| NADSYN1 | 10561.0 | 10871 |
| NAGLU | 12163.0 | -5299 |
| NAGS | 11887.0 | -8985 |
| NAMPT | 7134.0 | -10751 |
| NAPRT | -7216.0 | 11398 |
| NAT1 | -2142.0 | 7115 |
| NAT8L | -4195.0 | -9350 |
| NAXD | 3182.0 | 9993 |
| NAXE | 6657.0 | 10443 |
| NCAN | 3533.0 | -1773 |
| NCOA1 | 4263.0 | -8396 |
| NCOA2 | -6710.0 | -10904 |
| NCOA3 | -11270.0 | -11034 |
| NCOA6 | -1205.0 | -9301 |
| NCOR1 | -8203.0 | -6322 |
| NCOR2 | 12175.0 | -9615 |
| NDC1 | -5800.0 | -9199 |
| NDOR1 | 9246.0 | 12234 |
| NDST1 | 8645.0 | -10698 |
| NDST2 | -5061.0 | -9644 |
| NDST3 | 1659.0 | 3776 |
| NDUFA1 | -6222.0 | 13127 |
| NDUFA10 | -7241.0 | -4285 |
| NDUFA11 | 9807.0 | 12851 |
| NDUFA12 | 6720.0 | 13048 |
| NDUFA13 | -4424.0 | 12971 |
| NDUFA2 | 5937.0 | 13125 |
| NDUFA3 | -4508.0 | 13084 |
| NDUFA4 | 9132.0 | 11345 |
| NDUFA5 | -6593.0 | 11094 |
| NDUFA6 | -10640.0 | 12901 |
| NDUFA7 | 8872.0 | 13143 |
| NDUFA8 | -8774.0 | 12900 |
| NDUFA9 | 2605.0 | 10360 |
| NDUFAB1 | -10558.0 | 8746 |
| NDUFAF1 | 2883.0 | 9463 |
| NDUFAF2 | -5167.0 | 12574 |
| NDUFAF3 | 10175.0 | 13112 |
| NDUFAF4 | -8760.0 | 9608 |
| NDUFAF5 | -3460.0 | 9719 |
| NDUFAF6 | -5625.0 | 10508 |
| NDUFAF7 | 6751.0 | 8883 |
| NDUFB1 | 8092.0 | 13163 |
| NDUFB10 | -9687.0 | 12582 |
| NDUFB11 | -7090.0 | 11583 |
| NDUFB2 | 11367.0 | 12511 |
| NDUFB3 | 1661.0 | 12046 |
| NDUFB4 | 8888.0 | 13008 |
| NDUFB5 | -3244.0 | -5075 |
| NDUFB6 | -8238.0 | 12165 |
| NDUFB7 | -4205.0 | 12444 |
| NDUFB8 | 8367.0 | 13039 |
| NDUFB9 | -8544.0 | 12805 |
| NDUFC1 | -7186.0 | 12437 |
| NDUFC2 | -5184.0 | 11409 |
| NDUFS1 | -9609.0 | -7041 |
| NDUFS2 | 3967.0 | -10068 |
| NDUFS3 | -8653.0 | 12725 |
| NDUFS4 | 6388.0 | 3949 |
| NDUFS5 | -6394.0 | 13145 |
| NDUFS6 | -6327.0 | 12108 |
| NDUFS7 | 5531.0 | 12411 |
| NDUFS8 | -7989.0 | 12773 |
| NDUFV1 | -5404.0 | 8980 |
| NDUFV2 | -6865.0 | 13148 |
| NDUFV3 | -6779.0 | 12304 |
| NEU1 | -9477.0 | 3790 |
| NEU2 | 8005.0 | -3528 |
| NEU3 | -10525.0 | -8697 |
| NEU4 | -5702.0 | 3121 |
| NFS1 | -8587.0 | -4816 |
| NFYA | -10786.0 | -9963 |
| NFYB | -5919.0 | 7739 |
| NFYC | -3340.0 | 12311 |
| NHLRC1 | 9210.0 | 6494 |
| NME1 | 11440.0 | 13153 |
| NME2 | -5201.0 | 12533 |
| NME3 | -5191.0 | 12634 |
| NME4 | -8955.0 | 12904 |
| NMNAT1 | 9753.0 | -6068 |
| NMNAT2 | 12841.0 | -10949 |
| NMNAT3 | 7770.0 | 7639 |
| NMRAL1 | -6580.0 | 12010 |
| NMRK1 | 5933.0 | 11386 |
| NNMT | 12760.0 | 12864 |
| NNT | 4483.0 | -10790 |
| NOS3 | 476.0 | -957 |
| NOSIP | -8746.0 | 12178 |
| NOSTRIN | 5575.0 | 2554 |
| NPAS2 | 12099.0 | 11727 |
| NQO1 | 12497.0 | 12065 |
| NQO2 | -6513.0 | 11746 |
| NR1D1 | -10996.0 | 4719 |
| NR1H2 | -3062.0 | 778 |
| NR1H3 | 10799.0 | 11178 |
| NRF1 | -9525.0 | -5711 |
| NSDHL | -3016.0 | 8446 |
| NT5C | 10036.0 | 12101 |
| NT5C1A | 1781.0 | 1506 |
| NT5C1B | -1290.0 | -1463 |
| NT5C2 | 4767.0 | 9082 |
| NT5C3A | -10068.0 | -3760 |
| NT5E | 12820.0 | -11134 |
| NT5M | -9526.0 | 10535 |
| NUBP1 | 2370.0 | 12120 |
| NUBP2 | -10078.0 | 11001 |
| NUBPL | 8039.0 | -8010 |
| NUDT1 | 3652.0 | 12359 |
| NUDT10 | -7704.0 | -4998 |
| NUDT11 | -10991.0 | -6828 |
| NUDT12 | -1385.0 | 3226 |
| NUDT13 | 8578.0 | 6754 |
| NUDT15 | -1862.0 | 8736 |
| NUDT16 | 12651.0 | -4262 |
| NUDT18 | 5922.0 | -1638 |
| NUDT19 | -4582.0 | -4496 |
| NUDT3 | 10097.0 | -10288 |
| NUDT4 | -7741.0 | -7716 |
| NUDT5 | 12333.0 | 10972 |
| NUDT7 | -4018.0 | -3308 |
| NUDT9 | -3389.0 | 11891 |
| NUP107 | 10317.0 | 11210 |
| NUP133 | 6251.0 | -8590 |
| NUP153 | -8447.0 | -10433 |
| NUP155 | 1534.0 | -10720 |
| NUP160 | -10172.0 | -9854 |
| NUP188 | -11151.0 | -5029 |
| NUP205 | 12369.0 | -7848 |
| NUP210 | 12856.0 | -5260 |
| NUP214 | -6331.0 | -6303 |
| NUP35 | -10251.0 | 8114 |
| NUP37 | 3092.0 | 10117 |
| NUP42 | 8137.0 | 9137 |
| NUP43 | -7490.0 | 9638 |
| NUP50 | -10234.0 | -3947 |
| NUP54 | -10563.0 | -8348 |
| NUP58 | -7370.0 | -10308 |
| NUP62 | -5900.0 | -6034 |
| NUP85 | 7849.0 | 10502 |
| NUP88 | -10968.0 | 2131 |
| NUP93 | -6918.0 | -6255 |
| NUP98 | -10847.0 | -10135 |
| OAT | 10923.0 | -3605 |
| OAZ1 | -5995.0 | 8537 |
| OAZ2 | 12305.0 | -4736 |
| OAZ3 | -4681.0 | -2934 |
| OCA2 | 11312.0 | -5329 |
| OCRL | -3909.0 | -8515 |
| ODC1 | -11548.0 | -8715 |
| OGDH | -5384.0 | -7828 |
| OLAH | 3779.0 | -3519 |
| OMD | 2559.0 | 1901 |
| OPLAH | 11715.0 | 8476 |
| ORMDL1 | -10616.0 | 11044 |
| ORMDL2 | 10809.0 | 11899 |
| ORMDL3 | 7073.0 | -1824 |
| OSBP | -11432.0 | -11066 |
| OSBPL10 | 12422.0 | -10923 |
| OSBPL1A | 7299.0 | -9190 |
| OSBPL2 | -7654.0 | -6073 |
| OSBPL3 | 11559.0 | -9445 |
| OSBPL5 | -8362.0 | -5759 |
| OSBPL6 | -10479.0 | -991 |
| OSBPL7 | 11008.0 | 10084 |
| OSBPL8 | -6521.0 | -10242 |
| OSBPL9 | -4447.0 | -7265 |
| OXCT1 | 7426.0 | -6662 |
| OXCT2 | 3882.0 | 8410 |
| PAICS | -8896.0 | -7785 |
| PANK1 | -4929.0 | -7711 |
| PANK2 | 7613.0 | 1651 |
| PANK3 | -4780.0 | -10399 |
| PANK4 | -7723.0 | 2162 |
| PAOX | 10273.0 | -5165 |
| PAPSS1 | -10307.0 | -3927 |
| PAPSS2 | 6847.0 | -10771 |
| PARP10 | -9582.0 | 8696 |
| PARP14 | 11854.0 | -6808 |
| PARP16 | -79.0 | -5042 |
| PARP4 | 12757.0 | -10992 |
| PARP6 | -7943.0 | 9905 |
| PARP8 | 12354.0 | -8651 |
| PARP9 | 12239.0 | -4266 |
| PC | 10642.0 | -7758 |
| PCBD1 | 10442.0 | 9074 |
| PCCA | 11484.0 | -7458 |
| PCCB | 2928.0 | -5796 |
| PCK1 | 3254.0 | 4600 |
| PCK2 | 11395.0 | -398 |
| PCTP | 12215.0 | -8293 |
| PCYT1A | 1479.0 | -5733 |
| PCYT2 | -7783.0 | 12466 |
| PDHA1 | -10664.0 | 11842 |
| PDHB | -3368.0 | 12152 |
| PDHX | -9039.0 | -4928 |
| PDK1 | -5018.0 | -9225 |
| PDK2 | 11377.0 | 2039 |
| PDK3 | -6613.0 | -8798 |
| PDK4 | 10934.0 | -3798 |
| PDP1 | 11745.0 | -9417 |
| PDP2 | -8514.0 | -8538 |
| PDPR | -6645.0 | -8103 |
| PDSS1 | 5649.0 | 8667 |
| PDSS2 | -4701.0 | -6190 |
| PDXK | -11035.0 | -5417 |
| PDZD11 | 10212.0 | 12640 |
| PECR | 7959.0 | 7794 |
| PEMT | -5793.0 | 8198 |
| PEX11A | -3152.0 | -1150 |
| PFAS | 10370.0 | 10384 |
| PFKFB1 | 3220.0 | 5029 |
| PFKFB2 | 1610.0 | -3293 |
| PFKFB3 | 12759.0 | -11276 |
| PFKFB4 | 12732.0 | 8429 |
| PFKL | -5109.0 | -8972 |
| PFKM | -7607.0 | -7918 |
| PFKP | -384.0 | -10110 |
| PGAM1 | 3645.0 | -10719 |
| PGAM2 | 1166.0 | -1455 |
| PGD | -7202.0 | -354 |
| PGK1 | 9259.0 | -11156 |
| PGLS | 7112.0 | 12391 |
| PGM1 | 12049.0 | -11238 |
| PGM2 | -11358.0 | -9219 |
| PGM2L1 | -11266.0 | -9885 |
| PGP | 8613.0 | 12495 |
| PGS1 | -5196.0 | -5724 |
| PHGDH | 10381.0 | 12550 |
| PHKA1 | 2980.0 | -8258 |
| PHKA2 | -9682.0 | 11144 |
| PHKB | 10976.0 | -3464 |
| PHKG1 | 2679.0 | 9646 |
| PHKG2 | -2952.0 | 12137 |
| PHOSPHO1 | -4356.0 | 8844 |
| PHYH | 8745.0 | 2071 |
| PHYKPL | 12650.0 | 4336 |
| PI4K2A | -7282.0 | -6755 |
| PI4K2B | -4371.0 | -7468 |
| PI4KA | 10503.0 | -5896 |
| PI4KB | 5739.0 | -10289 |
| PIAS4 | -9983.0 | -3860 |
| PIK3C2A | -5604.0 | -9519 |
| PIK3C2B | 7510.0 | -6252 |
| PIK3C3 | -8170.0 | -7865 |
| PIK3CA | -5426.0 | -9599 |
| PIK3CB | -9217.0 | -10250 |
| PIK3CD | 8125.0 | -9524 |
| PIK3CG | 8376.0 | -5110 |
| PIK3R1 | 10169.0 | -9568 |
| PIK3R2 | -6506.0 | -5848 |
| PIK3R3 | 9654.0 | -3457 |
| PIK3R4 | 9611.0 | -9422 |
| PIK3R5 | -1767.0 | 107 |
| PIK3R6 | 12716.0 | -2472 |
| PIKFYVE | -10388.0 | -10306 |
| PIP4K2A | 8236.0 | -8090 |
| PIP4K2B | -3399.0 | 1126 |
| PIP4K2C | 8425.0 | -9498 |
| PIP5K1A | 7428.0 | -9178 |
| PIP5K1B | 6218.0 | -6738 |
| PIP5K1C | -7525.0 | -1015 |
| PIPOX | 3326.0 | -2663 |
| PISD | -10547.0 | 4750 |
| PITPNB | -10732.0 | -8304 |
| PITPNM1 | -9832.0 | -10911 |
| PITPNM2 | -6158.0 | -4679 |
| PITPNM3 | 462.0 | 2559 |
| PKM | 9491.0 | -8585 |
| PLA1A | 1097.0 | 1226 |
| PLA2G10 | 301.0 | 4728 |
| PLA2G12A | 8760.0 | -7403 |
| PLA2G15 | -6553.0 | -5088 |
| PLA2G4A | -11353.0 | -9250 |
| PLA2G4B | 6200.0 | 13064 |
| PLA2G4C | 9981.0 | -5934 |
| PLA2G4D | 1634.0 | 4664 |
| PLA2G5 | -11263.0 | 7586 |
| PLA2G6 | -8707.0 | 12727 |
| PLA2R1 | 12453.0 | -6182 |
| PLAAT1 | 2388.0 | -4908 |
| PLAAT3 | 12878.0 | 12588 |
| PLAAT4 | 10410.0 | 12384 |
| PLB1 | -664.0 | 4620 |
| PLBD1 | 12507.0 | 39 |
| PLCB2 | 370.0 | 6728 |
| PLCB3 | -6925.0 | -1610 |
| PLCB4 | 11654.0 | 3834 |
| PLCD1 | 8414.0 | -5958 |
| PLCD3 | 10005.0 | -5698 |
| PLCD4 | -1787.0 | 3553 |
| PLCE1 | 9674.0 | -3943 |
| PLCG1 | -8518.0 | 10852 |
| PLCG2 | -6464.0 | -3252 |
| PLCH1 | -4082.0 | -4387 |
| PLCH2 | 5087.0 | -8743 |
| PLD1 | 12766.0 | -9763 |
| PLD2 | -7320.0 | -7936 |
| PLD3 | 9531.0 | -3623 |
| PLD4 | 2571.0 | 7880 |
| PLD6 | -11240.0 | -2847 |
| PLEKHA1 | -5829.0 | -10175 |
| PLEKHA2 | -11451.0 | -10431 |
| PLEKHA3 | -9653.0 | -6310 |
| PLEKHA4 | -3065.0 | 10468 |
| PLEKHA5 | -8831.0 | -7991 |
| PLEKHA6 | 10937.0 | 7485 |
| PLEKHA8 | 5033.0 | -9481 |
| PLIN1 | -6085.0 | 2234 |
| PLIN2 | 12727.0 | -5631 |
| PLIN3 | -6142.0 | -11153 |
| PLPP1 | -8524.0 | -1473 |
| PLPP2 | 11795.0 | 9587 |
| PLPP3 | 12490.0 | -10087 |
| PLPP6 | 6732.0 | -6196 |
| PMVK | 8931.0 | 4934 |
| PNMT | 6175.0 | 5951 |
| PNP | -10127.0 | -10176 |
| PNPLA2 | -6634.0 | -2945 |
| PNPLA3 | -9617.0 | -8407 |
| PNPLA4 | -2168.0 | 3810 |
| PNPLA6 | -9579.0 | -4893 |
| PNPLA7 | 4383.0 | 9842 |
| PNPLA8 | -10281.0 | -8614 |
| PNPO | 10866.0 | 1005 |
| PODXL2 | 1240.0 | 10387 |
| POLD1 | 10830.0 | 8156 |
| POM121 | -8878.0 | -9749 |
| POM121C | -9406.0 | -9089 |
| PON2 | 11322.0 | 1907 |
| POR | -10842.0 | 374 |
| PPA1 | -5474.0 | -3678 |
| PPA2 | -8673.0 | 6936 |
| PPARA | -8366.0 | -11101 |
| PPARD | -11069.0 | 6617 |
| PPARG | 12799.0 | 9364 |
| PPARGC1A | 10444.0 | -5499 |
| PPARGC1B | -11191.0 | -6465 |
| PPAT | -10102.0 | -9936 |
| PPCDC | 11861.0 | 11034 |
| PPCS | -1448.0 | 9746 |
| PPIP5K1 | 12627.0 | -1301 |
| PPIP5K2 | 1304.0 | -10134 |
| PPM1K | -9252.0 | -7689 |
| PPM1L | -7048.0 | -9180 |
| PPOX | 8950.0 | 11264 |
| PPP1CA | 4929.0 | 7585 |
| PPP1CB | -5856.0 | -9212 |
| PPP1CC | -9143.0 | -9771 |
| PPP1R3C | 10573.0 | -5635 |
| PPP2CA | -3124.0 | -7225 |
| PPP2CB | -11374.0 | -10028 |
| PPP2R1A | -9193.0 | -4828 |
| PPP2R1B | 6255.0 | -5465 |
| PPP2R5D | -11383.0 | -11113 |
| PPT1 | 9505.0 | -3741 |
| PPT2 | 6099.0 | -1615 |
| PRELP | 4474.0 | 2215 |
| PRKAA2 | -3279.0 | -8609 |
| PRKAB2 | -7701.0 | -10925 |
| PRKACA | 8250.0 | 9679 |
| PRKACB | 8849.0 | -9614 |
| PRKAG2 | 9883.0 | -5624 |
| PRKAR1A | 8600.0 | -10630 |
| PRKAR1B | 8608.0 | -4934 |
| PRKAR2A | -5980.0 | -10943 |
| PRKAR2B | -9276.0 | -5166 |
| PRKCA | 12366.0 | -10396 |
| PRKD1 | 10025.0 | -8707 |
| PRKD2 | -7712.0 | -10335 |
| PRKD3 | 3551.0 | -10820 |
| PRKG2 | 95.0 | -2178 |
| PRODH | 4648.0 | 8935 |
| PRPS1 | -4640.0 | -7852 |
| PRPS2 | -10777.0 | -5424 |
| PRSS1 | -6231.0 | 725 |
| PRSS3 | -11534.0 | -3851 |
| PRXL2B | 2450.0 | 2967 |
| PSAP | 10899.0 | -11185 |
| PSAT1 | -8575.0 | 11575 |
| PSMA1 | -9646.0 | 10578 |
| PSMA2 | -4002.0 | -4430 |
| PSMA3 | -5668.0 | 12561 |
| PSMA4 | -9907.0 | 11447 |
| PSMA5 | 5538.0 | 826 |
| PSMA6 | -3328.0 | 8997 |
| PSMA7 | -10164.0 | -7607 |
| PSMB1 | -6139.0 | 12480 |
| PSMB10 | 9537.0 | 11663 |
| PSMB2 | -3364.0 | 8976 |
| PSMB3 | 7905.0 | 13078 |
| PSMB4 | -1370.0 | 12998 |
| PSMB5 | -6937.0 | -2970 |
| PSMB6 | -6537.0 | 10901 |
| PSMB7 | -8656.0 | 12462 |
| PSMB8 | -9783.0 | 11153 |
| PSMB9 | -9810.0 | 10733 |
| PSMC1 | -3547.0 | -3814 |
| PSMC2 | -9185.0 | 11068 |
| PSMC3 | -1273.0 | 12327 |
| PSMC4 | -7156.0 | 12714 |
| PSMC5 | 7024.0 | 12041 |
| PSMC6 | -7069.0 | 697 |
| PSMD1 | -9192.0 | -10441 |
| PSMD10 | -6869.0 | 1286 |
| PSMD11 | 7720.0 | -8518 |
| PSMD12 | 813.0 | 8775 |
| PSMD13 | -5300.0 | 12140 |
| PSMD14 | -10615.0 | 8461 |
| PSMD2 | -6801.0 | -10378 |
| PSMD3 | -8058.0 | -4798 |
| PSMD4 | 743.0 | 11756 |
| PSMD5 | -9642.0 | -8039 |
| PSMD6 | -7577.0 | 12228 |
| PSMD7 | -6198.0 | -6043 |
| PSMD8 | -9103.0 | -6526 |
| PSMD9 | -7638.0 | -3346 |
| PSME1 | -8654.0 | 11878 |
| PSME2 | -4231.0 | 12869 |
| PSME3 | 11811.0 | -7813 |
| PSME4 | -10581.0 | -10843 |
| PSMF1 | -7549.0 | -4369 |
| PSPH | 11422.0 | 7040 |
| PSTK | 5756.0 | 9314 |
| PTDSS1 | -4830.0 | -8543 |
| PTDSS2 | 10798.0 | 5487 |
| PTEN | -6933.0 | -8533 |
| PTGDS | 5712.0 | -326 |
| PTGES | -10205.0 | 12283 |
| PTGES2 | 8987.0 | 10737 |
| PTGES3 | -9501.0 | -9810 |
| PTGIS | -4112.0 | -2751 |
| PTGR1 | 12337.0 | -7704 |
| PTGR2 | 11100.0 | 8783 |
| PTGS2 | -7696.0 | -11040 |
| PTPMT1 | -6485.0 | 12300 |
| PTPN13 | 12622.0 | -7833 |
| PTS | -1728.0 | 12054 |
| PUDP | 5935.0 | -5772 |
| PXMP2 | 10630.0 | 4583 |
| PYCR1 | -4927.0 | -11012 |
| PYCR2 | 9765.0 | 12269 |
| PYGB | -11296.0 | -9947 |
| PYGL | -8006.0 | -10425 |
| PYGM | 859.0 | 5254 |
| QARS1 | 10134.0 | -6688 |
| QDPR | 11360.0 | -6120 |
| QPRT | -11532.0 | 9751 |
| RAB14 | -9162.0 | -10367 |
| RAB4A | 6470.0 | -4166 |
| RAB5A | -7843.0 | -8483 |
| RAE1 | -7356.0 | -5016 |
| RAN | -5185.0 | 5548 |
| RANBP2 | -5941.0 | -10334 |
| RAP1A | -1904.0 | -6372 |
| RAPGEF3 | -9262.0 | -7226 |
| RAPGEF4 | 5782.0 | 8179 |
| RARS1 | -9720.0 | -7252 |
| RBKS | 11087.0 | 5114 |
| RBP1 | 11319.0 | 11694 |
| RBP4 | 10591.0 | 11534 |
| RDH11 | -10607.0 | -304 |
| RETSAT | -2685.0 | -8033 |
| RFK | -4905.0 | -6715 |
| RGL1 | 12783.0 | -10360 |
| RHCE | 214.0 | -4595 |
| RHD | 808.0 | 1770 |
| RIDA | -72.0 | 11337 |
| RIMKLA | 12748.0 | -8994 |
| RIMKLB | -8314.0 | 347 |
| RNLS | 266.0 | 751 |
| RORA | -161.0 | -8980 |
| RPE | -6092.0 | -5602 |
| RPIA | -1807.0 | -4134 |
| RPL10 | -3821.0 | 1597 |
| RPL10A | -9707.0 | -8212 |
| RPL11 | -8529.0 | 12382 |
| RPL12 | -9329.0 | 12992 |
| RPL13 | -3469.0 | 12598 |
| RPL13A | -6854.0 | 6955 |
| RPL14 | -6386.0 | 13137 |
| RPL15 | -786.0 | 12153 |
| RPL17 | -8989.0 | 12909 |
| RPL18 | -6672.0 | 12800 |
| RPL18A | -6976.0 | 11926 |
| RPL19 | 3924.0 | 12911 |
| RPL21 | -6322.0 | 5141 |
| RPL22 | -5554.0 | 9520 |
| RPL22L1 | -10448.0 | 12221 |
| RPL23 | 5769.0 | 12922 |
| RPL23A | 11361.0 | -5257 |
| RPL24 | -4591.0 | 12995 |
| RPL26 | -8797.0 | 12658 |
| RPL26L1 | -9387.0 | 12770 |
| RPL27 | 6735.0 | 11625 |
| RPL27A | -7818.0 | 13051 |
| RPL28 | -5809.0 | 12962 |
| RPL29 | -4515.0 | 12915 |
| RPL3 | -6827.0 | -4535 |
| RPL30 | -3907.0 | 11096 |
| RPL31 | -8781.0 | 13131 |
| RPL32 | -5028.0 | 12983 |
| RPL34 | -9357.0 | 12996 |
| RPL35 | -8027.0 | 13097 |
| RPL35A | -1449.0 | 12789 |
| RPL36 | -8818.0 | 12868 |
| RPL36A | -4480.0 | 13009 |
| RPL36AL | -8216.0 | 12702 |
| RPL37 | -4624.0 | 13134 |
| RPL37A | -9347.0 | 12675 |
| RPL38 | 1558.0 | 13140 |
| RPL39 | -6168.0 | 11962 |
| RPL39L | -6608.0 | -6269 |
| RPL3L | -510.0 | 7904 |
| RPL4 | 11351.0 | 12558 |
| RPL41 | -4616.0 | -6074 |
| RPL5 | 4679.0 | 12075 |
| RPL6 | -6903.0 | 12730 |
| RPL7 | -3327.0 | -8789 |
| RPL7A | -6163.0 | 11708 |
| RPL8 | -7572.0 | 10323 |
| RPL9 | -9659.0 | 12806 |
| RPLP0 | -1504.0 | -7331 |
| RPLP1 | 9026.0 | 12731 |
| RPLP2 | -8225.0 | 12999 |
| RPS10 | -8384.0 | 10665 |
| RPS11 | -7725.0 | 12935 |
| RPS12 | -7872.0 | 11600 |
| RPS13 | -9450.0 | 12652 |
| RPS14 | -1180.0 | 12428 |
| RPS15 | -7430.0 | 12908 |
| RPS15A | -8754.0 | 12989 |
| RPS16 | -3844.0 | 12941 |
| RPS17 | -10534.0 | 11631 |
| RPS18 | -9122.0 | 12984 |
| RPS19 | -7633.0 | 12888 |
| RPS2 | -10222.0 | 8916 |
| RPS20 | -4961.0 | 13095 |
| RPS21 | -3001.0 | 13022 |
| RPS23 | 6940.0 | 11907 |
| RPS24 | 2369.0 | 13034 |
| RPS25 | -9371.0 | 12690 |
| RPS26 | -2615.0 | 13114 |
| RPS27 | 651.0 | 11270 |
| RPS27A | 5357.0 | 6464 |
| RPS27L | 7330.0 | 12750 |
| RPS28 | 2716.0 | 12485 |
| RPS29 | -652.0 | 9078 |
| RPS3 | -7756.0 | 12135 |
| RPS3A | -9170.0 | 5257 |
| RPS4X | -8542.0 | 12239 |
| RPS5 | -6283.0 | -7965 |
| RPS6 | -9225.0 | 12405 |
| RPS7 | 5142.0 | 12976 |
| RPS8 | -5812.0 | 12745 |
| RPS9 | -8815.0 | 10189 |
| RPSA | 292.0 | 11576 |
| RRM1 | 6359.0 | -7531 |
| RRM2 | 12419.0 | -2007 |
| RRM2B | -1200.0 | -8759 |
| RTEL1 | 11373.0 | 11890 |
| RUFY1 | -2346.0 | 11546 |
| RXRA | -9975.0 | -6008 |
| RXRB | -9927.0 | -7550 |
| SACM1L | -7553.0 | -7666 |
| SAMD8 | -7692.0 | -9284 |
| SAMHD1 | 11969.0 | -4728 |
| SAR1B | 6713.0 | 9055 |
| SARDH | 11797.0 | -2513 |
| SARS1 | 10748.0 | -9421 |
| SAT1 | -11516.0 | 8580 |
| SBF1 | -7013.0 | -7405 |
| SBF2 | -7579.0 | -11053 |
| SC5D | -9936.0 | -9554 |
| SCAP | 10207.0 | -6793 |
| SCD | -6967.0 | -8469 |
| SCD5 | -8562.0 | -8561 |
| SCLY | -9481.0 | 10671 |
| SCO1 | -10631.0 | -6537 |
| SCO2 | -9739.0 | 9526 |
| SCP2 | 11683.0 | -5644 |
| SDC1 | 12230.0 | -7104 |
| SDC2 | -6754.0 | -5737 |
| SDC3 | 12401.0 | -6760 |
| SDC4 | 12322.0 | -10633 |
| SDHA | -10480.0 | -9986 |
| SDHB | -299.0 | 5982 |
| SDHC | 9345.0 | -5559 |
| SDHD | -9641.0 | -2716 |
| SDS | 3809.0 | 3212 |
| SDSL | 11650.0 | 4044 |
| SEC13 | -9702.0 | -8646 |
| SEC23A | 6211.0 | -11247 |
| SEC24A | 8771.0 | -11248 |
| SEC24B | -10249.0 | -10349 |
| SEC24C | 8468.0 | -11142 |
| SEC24D | -11430.0 | -11236 |
| SECISBP2 | 11207.0 | -6517 |
| SEH1L | -9333.0 | -5653 |
| SELENOI | -6323.0 | -9929 |
| SEM1 | -9978.0 | 13108 |
| SEPHS2 | 8103.0 | -351 |
| SEPSECS | -6443.0 | -5096 |
| SERINC1 | -8559.0 | -10927 |
| SERINC2 | 12901.0 | -4299 |
| SERINC3 | -9690.0 | -10718 |
| SERINC5 | -10855.0 | -10123 |
| SERPINA6 | 5214.0 | 7999 |
| SGMS1 | -3969.0 | -9918 |
| SGMS2 | 9854.0 | -8817 |
| SGPL1 | -6129.0 | -9743 |
| SGPP1 | -3002.0 | -9260 |
| SGPP2 | -3985.0 | 7799 |
| SGSH | 11466.0 | 8231 |
| SHMT1 | 10041.0 | 12191 |
| SHMT2 | 7127.0 | 150 |
| SHPK | -9246.0 | -7292 |
| SIN3A | 9736.0 | -10233 |
| SIN3B | -7946.0 | 11143 |
| SLC16A1 | -10562.0 | -9859 |
| SLC16A3 | 11791.0 | -6452 |
| SLC19A1 | 9060.0 | 8496 |
| SLC19A2 | -6303.0 | -8882 |
| SLC19A3 | -3908.0 | 3914 |
| SLC22A1 | 1198.0 | 3444 |
| SLC22A13 | -648.0 | 2062 |
| SLC22A5 | 3024.0 | 2375 |
| SLC23A1 | 3168.0 | 3672 |
| SLC23A2 | 6485.0 | -5846 |
| SLC25A1 | -6507.0 | 7710 |
| SLC25A10 | 10535.0 | 10876 |
| SLC25A11 | 6783.0 | 9521 |
| SLC25A12 | 9436.0 | 5342 |
| SLC25A13 | 12236.0 | -4102 |
| SLC25A14 | 4056.0 | 10282 |
| SLC25A15 | -8051.0 | -6219 |
| SLC25A16 | 9109.0 | 12013 |
| SLC25A17 | -10034.0 | 281 |
| SLC25A19 | -9222.0 | 11652 |
| SLC25A20 | 8585.0 | -5523 |
| SLC25A21 | 1939.0 | -353 |
| SLC25A27 | 10480.0 | 12786 |
| SLC25A28 | -2674.0 | 12676 |
| SLC25A32 | -5445.0 | -9505 |
| SLC25A37 | -9868.0 | 12952 |
| SLC25A44 | 8439.0 | -6942 |
| SLC26A1 | 7040.0 | 3908 |
| SLC26A2 | -4295.0 | -10449 |
| SLC27A1 | 4552.0 | -6579 |
| SLC27A2 | 10536.0 | -569 |
| SLC27A3 | 11824.0 | 2868 |
| SLC27A5 | 8599.0 | 9718 |
| SLC2A1 | 12313.0 | -10164 |
| SLC2A3 | -6111.0 | -11283 |
| SLC35B2 | 9973.0 | -9792 |
| SLC35B3 | -7199.0 | -6153 |
| SLC35D1 | 1678.0 | -8747 |
| SLC35D2 | 10637.0 | -6268 |
| SLC36A4 | -1600.0 | -8668 |
| SLC37A1 | -5220.0 | -5226 |
| SLC37A2 | 12828.0 | -1380 |
| SLC37A4 | -6962.0 | 9471 |
| SLC3A2 | -9319.0 | -3436 |
| SLC44A1 | 3030.0 | -8195 |
| SLC44A2 | 11423.0 | -6429 |
| SLC44A3 | 9846.0 | -2785 |
| SLC44A5 | 8809.0 | -7261 |
| SLC46A1 | 11747.0 | -4346 |
| SLC51A | -3285.0 | 5328 |
| SLC51B | 9192.0 | -4447 |
| SLC52A1 | -3647.0 | 4492 |
| SLC52A2 | -7721.0 | -5238 |
| SLC52A3 | 1848.5 | 3302 |
| SLC5A5 | 5760.0 | 4246 |
| SLC5A6 | -9022.0 | 7606 |
| SLC6A11 | 10785.0 | -3525 |
| SLC6A12 | -4244.0 | 1206 |
| SLC6A8 | 12417.0 | -9058 |
| SLC7A5 | -9076.0 | -4839 |
| SLC9A1 | 8241.0 | -5276 |
| SLCO1B3 | 6971.0 | -2291 |
| SMARCD3 | 11978.0 | 11422 |
| SMOX | -3994.0 | -11021 |
| SMPD1 | -8640.0 | -6846 |
| SMPD2 | -7448.0 | 8682 |
| SMPD3 | 7325.0 | 10000 |
| SMPD4 | -8916.0 | 9507 |
| SMS | -11167.0 | -1993 |
| SNAP25 | 11071.0 | 12085 |
| SORD | -9421.0 | -8553 |
| SP1 | -10121.0 | -9960 |
| SPHK1 | -11193.0 | -9551 |
| SPHK2 | 996.0 | -3963 |
| SPNS2 | 6707.0 | 3611 |
| SPR | -4539.0 | 9702 |
| SPTLC1 | -8629.0 | -8361 |
| SPTLC2 | -7631.0 | -10853 |
| SPTLC3 | 7149.0 | -1127 |
| SPTSSA | -3187.0 | -2030 |
| SPTSSB | -483.0 | 241 |
| SQLE | -11257.0 | -9793 |
| SRD5A1 | -7401.0 | -5993 |
| SRD5A3 | 6201.0 | -9627 |
| SREBF1 | 8797.0 | 11668 |
| SREBF2 | -10833.0 | -10659 |
| SRM | -7150.0 | 11902 |
| SRR | -6159.0 | 7210 |
| ST3GAL1 | 12199.0 | -11061 |
| ST3GAL2 | 9077.0 | -8211 |
| ST3GAL3 | -7104.0 | -4100 |
| ST3GAL4 | -9632.0 | 6643 |
| ST3GAL6 | -11458.0 | -3139 |
| ST6GALNAC6 | -10366.0 | -4890 |
| STARD10 | -11280.0 | 10122 |
| STARD3 | -3161.0 | -529 |
| STARD3NL | 11304.0 | -7611 |
| STARD4 | -3584.0 | -8370 |
| STARD5 | 7138.0 | 8173 |
| STARD6 | 4681.0 | -390 |
| STARD7 | 5228.0 | -9022 |
| STK11 | -8395.0 | 11292 |
| STS | 6761.0 | -3002 |
| STX1A | -10779.0 | 11790 |
| STXBP1 | -9033.0 | -10503 |
| SUCLA2 | 3325.0 | -7651 |
| SUCLG1 | 1114.0 | 10597 |
| SUCLG2 | -6338.0 | -8917 |
| SULT1A1 | 1568.0 | 8030 |
| SULT1A2 | 2933.0 | -775 |
| SULT1A3 | -3988.0 | 10985 |
| SULT1A4 | -5014.0 | 6668 |
| SULT1B1 | -7930.0 | 3832 |
| SULT1C2 | 9680.0 | 12144 |
| SULT1C4 | 6652.0 | -925 |
| SULT2A1 | 3725.0 | 1880 |
| SULT4A1 | -7305.0 | 12214 |
| SUMF1 | 11852.0 | -4769 |
| SUMF2 | 11753.0 | -9338 |
| SUMO2 | -4403.0 | -3595 |
| SUOX | 11819.0 | 9645 |
| SURF1 | 8003.0 | 9112 |
| SYNJ1 | -6939.0 | -6072 |
| SYNJ2 | 7547.0 | -5487 |
| SYT5 | -10749.0 | -3988 |
| TACO1 | 8239.0 | 8081 |
| TALDO1 | -9895.0 | 11544 |
| TAT | 4699.0 | 448 |
| TAZ | 8218.0 | 12600 |
| TBL1X | -8568.0 | -8247 |
| TBL1XR1 | -3958.0 | -9641 |
| TBXAS1 | 11359.0 | 12456 |
| TCN2 | -7499.0 | -1779 |
| TDO2 | 8914.0 | 5887 |
| TECR | 6238.0 | 12948 |
| TGS1 | -7713.0 | -7446 |
| THEM4 | 12470.0 | 11368 |
| THRAP3 | -6692.0 | -5191 |
| THTPA | 11609.0 | -6656 |
| TIAM2 | 606.0 | -5687 |
| TIMMDC1 | 9211.0 | -3329 |
| TK1 | 8640.0 | 12195 |
| TK2 | 11223.0 | 11430 |
| TKFC | 10845.0 | -2395 |
| TKT | -10316.0 | 1857 |
| TM7SF2 | 9323.0 | 12506 |
| TMEM126B | -8036.0 | 9815 |
| TMEM186 | -8187.0 | 5086 |
| TMEM86B | -4684.0 | 10657 |
| TMLHE | 10560.0 | -7649 |
| TNFAIP8 | -8871.0 | -5353 |
| TNFAIP8L1 | -9972.0 | -6812 |
| TNFAIP8L3 | 6293.0 | 3816 |
| TNFRSF21 | 9967.0 | -10315 |
| TPH1 | 3976.0 | 9198 |
| TPH2 | -308.0 | 7806 |
| TPI1 | 9519.0 | -7935 |
| TPK1 | 11149.0 | -4885 |
| TPMT | -9585.0 | 5970 |
| TPO | 4072.0 | 7357 |
| TPR | 8761.0 | -5834 |
| TPST1 | 7014.0 | -8349 |
| TPST2 | -10253.0 | -10663 |
| TRAP1 | -11197.0 | 8602 |
| TRIB3 | -3221.0 | -5552 |
| TRMT112 | -5741.0 | 13057 |
| TSPO | -10371.0 | 4351 |
| TST | 9957.0 | 10661 |
| TTPA | 8342.0 | 2897 |
| TTR | -212.0 | 1928 |
| TXN | -7456.0 | 12957 |
| TXN2 | -8694.0 | 3274 |
| TXNRD1 | -10964.0 | -9955 |
| TYMP | 12562.0 | 8603 |
| TYMS | 7752.0 | 511 |
| UBA52 | -6807.0 | 11639 |
| UBB | -5602.0 | 12024 |
| UBC | -10397.0 | 7017 |
| UBE2I | -10489.0 | 6476 |
| UBIAD1 | -9372.0 | -6426 |
| UCK1 | -6591.0 | 10329 |
| UCK2 | 6859.0 | -5920 |
| UCKL1 | 8998.0 | 12133 |
| UCP2 | 11830.0 | 11257 |
| UCP3 | 2795.0 | 9619 |
| UGCG | -1667.0 | -7173 |
| UGDH | -9991.0 | -9957 |
| UGP2 | 12203.0 | -10131 |
| UGT1A1 | 56.0 | 2625 |
| UGT1A7 | 2395.0 | 8771 |
| UGT3A2 | 7384.0 | 5628 |
| UGT8 | 10288.0 | -6424 |
| UMPS | -2365.0 | -3118 |
| UPB1 | 7539.0 | -1133 |
| UPP1 | -7882.0 | -5275 |
| UQCR10 | -9028.0 | 12920 |
| UQCR11 | -5675.0 | 11509 |
| UQCRB | -979.0 | 12923 |
| UQCRC1 | 8588.0 | -1762 |
| UQCRC2 | -11089.0 | -6026 |
| UQCRFS1 | -10915.0 | -8657 |
| UQCRH | -8039.0 | 12733 |
| UQCRQ | 10244.0 | 13147 |
| UROD | 9947.0 | 12213 |
| UROS | 11889.0 | 11662 |
| UST | -6346.0 | -8615 |
| VAC14 | -9751.0 | -7774 |
| VAMP2 | -5460.0 | 9876 |
| VAPA | -10099.0 | -8584 |
| VAPB | 10592.0 | -8499 |
| VCAN | -1861.0 | -11263 |
| VDAC1 | 10321.0 | -414 |
| VDR | 11798.0 | -1940 |
| VKORC1 | -4765.0 | -4020 |
| VKORC1L1 | -10554.0 | -8838 |
| VNN1 | -2091.0 | -4 |
| VNN2 | 6843.0 | 4353 |
| WASL | -8668.0 | -8587 |
| XDH | -6425.0 | -6418 |
| XYLB | 3022.0 | 6371 |
| XYLT1 | -11081.0 | -10705 |
| XYLT2 | 10574.0 | -7316 |
| ZDHHC21 | -2971.0 | -2436 |
Resolution of D-Loop Structures
| metric | value |
|---|---|
| setSize | 33 |
| pMANOVA | 0.00394 |
| p.adjustMANOVA | 0.0043 |
| s.dist | 0.35 |
| s.KO | 0.241 |
| s.drug | 0.253 |
| p.KO | 0.0166 |
| p.drug | 0.0118 |
| Gene | KO | drug |
|---|---|---|
| EME1 | 11398 | 12799 |
| XRCC3 | 10913 | 12963 |
| RTEL1 | 11373 | 11890 |
| XRCC2 | 11675 | 11504 |
| GEN1 | 10900 | 11539 |
| EXO1 | 11028 | 10237 |
| RAD51C | 10266 | 10960 |
| DNA2 | 9182 | 12016 |
| RAD51AP1 | 10184 | 7752 |
| BRCA1 | 11931 | 5883 |
| RAD51D | 11272 | 5949 |
| BRIP1 | 9999 | 3512 |
| SLX4 | 9703 | 2427 |
| RMI2 | 1967 | 10674 |
Click HERE to show all gene set members
| KO | drug | |
|---|---|---|
| ATM | -300 | -6012 |
| BARD1 | -7617 | -5249 |
| BLM | -1023 | 11586 |
| BRCA1 | 11931 | 5883 |
| BRCA2 | 6854 | -3764 |
| BRIP1 | 9999 | 3512 |
| DNA2 | 9182 | 12016 |
| EME1 | 11398 | 12799 |
| EME2 | -5775 | 11911 |
| EXO1 | 11028 | 10237 |
| GEN1 | 10900 | 11539 |
| KAT5 | -9469 | 672 |
| MRE11 | -556 | 11374 |
| MUS81 | -2750 | 11766 |
| NBN | -3430 | -8967 |
| PALB2 | -9017 | -5142 |
| RAD50 | 5490 | -7933 |
| RAD51 | 11416 | -2838 |
| RAD51AP1 | 10184 | 7752 |
| RAD51B | 7746 | -2133 |
| RAD51C | 10266 | 10960 |
| RAD51D | 11272 | 5949 |
| RBBP8 | -9239 | 6461 |
| RMI1 | 8716 | -4304 |
| RMI2 | 1967 | 10674 |
| RTEL1 | 11373 | 11890 |
| SLX1A | -6724 | 11853 |
| SLX4 | 9703 | 2427 |
| SPIDR | 11752 | -3698 |
| TOP3A | -7604 | -6411 |
| WRN | -10934 | -5815 |
| XRCC2 | 11675 | 11504 |
| XRCC3 | 10913 | 12963 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.2.4 GGally_2.1.2
## [3] gtools_3.9.2 echarts4r_0.4.3
## [5] beeswarm_0.4.0 vioplot_0.3.7
## [7] sm_2.2-5.7 kableExtra_1.3.4
## [9] topconfects_1.8.0 limma_3.48.3
## [11] eulerr_6.1.1 mitch_1.4.1
## [13] MASS_7.3-56 fgsea_1.18.0
## [15] gplots_3.1.1 DESeq2_1.32.0
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0
## [19] MatrixGenerics_1.4.3 matrixStats_0.61.0
## [21] GenomicRanges_1.44.0 GenomeInfoDb_1.28.4
## [23] IRanges_2.26.0 S4Vectors_0.30.2
## [25] BiocGenerics_0.38.0 reshape2_1.4.4
## [27] forcats_0.5.1 stringr_1.4.0
## [29] dplyr_1.0.8 purrr_0.3.4
## [31] readr_2.1.2 tidyr_1.2.0
## [33] tibble_3.1.6 ggplot2_3.3.5
## [35] tidyverse_1.3.1 zoo_1.8-9
##
## loaded via a namespace (and not attached):
## [1] readxl_1.3.1 backports_1.4.1 fastmatch_1.1-3
## [4] systemfonts_1.0.4 plyr_1.8.6 polylabelr_0.2.0
## [7] splines_4.2.0 BiocParallel_1.26.2 digest_0.6.29
## [10] htmltools_0.5.2 fansi_1.0.2 magrittr_2.0.2
## [13] memoise_2.0.1 tzdb_0.2.0 Biostrings_2.60.2
## [16] annotate_1.70.0 modelr_0.1.8 svglite_2.1.0
## [19] colorspace_2.0-3 blob_1.2.2 rvest_1.0.2
## [22] haven_2.4.3 xfun_0.30 crayon_1.5.0
## [25] RCurl_1.98-1.6 jsonlite_1.8.0 genefilter_1.74.1
## [28] survival_3.3-1 glue_1.6.2 polyclip_1.10-0
## [31] gtable_0.3.0 zlibbioc_1.38.0 XVector_0.32.0
## [34] webshot_0.5.2 DelayedArray_0.18.0 scales_1.1.1
## [37] DBI_1.1.2 Rcpp_1.0.8.2 viridisLite_0.4.0
## [40] xtable_1.8-4 bit_4.0.4 htmlwidgets_1.5.4
## [43] httr_1.4.2 RColorBrewer_1.1-2 ellipsis_0.3.2
## [46] farver_2.1.0 pkgconfig_2.0.3 reshape_0.8.8
## [49] XML_3.99-0.9 sass_0.4.0 dbplyr_2.1.1
## [52] locfit_1.5-9.5 utf8_1.2.2 labeling_0.4.2
## [55] tidyselect_1.1.2 rlang_1.0.2 later_1.3.0
## [58] AnnotationDbi_1.54.1 munsell_0.5.0 cellranger_1.1.0
## [61] tools_4.2.0 cachem_1.0.6 cli_3.2.0
## [64] generics_0.1.2 RSQLite_2.2.10 broom_0.7.12
## [67] evaluate_0.15 fastmap_1.1.0 yaml_2.3.5
## [70] knitr_1.37 bit64_4.0.5 fs_1.5.2
## [73] caTools_1.18.2 KEGGREST_1.32.0 mime_0.12
## [76] xml2_1.3.3 compiler_4.2.0 rstudioapi_0.13
## [79] png_0.1-7 reprex_2.0.1 geneplotter_1.70.0
## [82] bslib_0.3.1 stringi_1.7.6 highr_0.9
## [85] desc_1.4.1 lattice_0.20-45 Matrix_1.4-1
## [88] vctrs_0.3.8 pillar_1.7.0 lifecycle_1.0.1
## [91] jquerylib_0.1.4 data.table_1.14.2 bitops_1.0-7
## [94] httpuv_1.6.5 R6_2.5.1 promises_1.2.0.1
## [97] KernSmooth_2.23-20 gridExtra_2.3 assertthat_0.2.1
## [100] rprojroot_2.0.2 withr_2.5.0 GenomeInfoDbData_1.2.6
## [103] hms_1.1.1 grid_4.2.0 rmarkdown_2.13
## [106] shiny_1.7.1 lubridate_1.8.0END of report