date generated: 2022-05-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   KO        drug
## 5_8S_rRNA -0.4520464  13.3743116
## 7SK       -2.2982399   8.2273688
## A1BG      -3.3008939   6.5686329
## A1BG-AS1   0.3211569   2.0364019
## A1CF      -0.7352419  -0.3353024
## A2M       30.2687300 -19.6842209
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genes_in_profile 24473
duplicated_genes_present 0
num_profile_genes_in_sets 2698
num_profile_genes_not_in_sets 21775
profile_pearson_correl 0.06908
profile_spearman_correl 0.09129

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:
Gene sets metrics
Gene sets metrics
num_genesets 24
num_genesets_excluded 0
num_genesets_included 24

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 24

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 24 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.KO s.drug p.KO p.drug
Mucopolysaccharidoses 11 1.36e-05 2.71e-05 0.799 0.7560 -0.2580 1.41e-05 1.38e-01
Reduction of cytosolic Ca++ levels 12 1.99e-04 2.80e-04 0.656 0.4230 -0.5020 1.12e-02 2.59e-03
Mitochondrial iron-sulfur cluster biogenesis 13 1.73e-04 2.77e-04 0.635 -0.4370 0.4620 6.39e-03 3.96e-03
Complex I biogenesis 57 8.21e-22 6.57e-21 0.740 -0.1230 0.7290 1.09e-01 1.49e-21
Respiratory electron transport 103 4.70e-27 5.64e-26 0.610 -0.1600 0.5890 4.90e-03 4.56e-25
Cellular response to starvation 150 2.14e-29 5.15e-28 0.518 -0.3220 0.4060 9.62e-12 9.26e-18
Stabilization of p53 53 9.56e-11 2.87e-10 0.515 -0.4250 0.2910 8.54e-08 2.43e-04
Mitochondrial translation 96 6.75e-20 4.05e-19 0.539 -0.1480 0.5180 1.21e-02 1.55e-18
Mitochondrial protein import 64 2.31e-07 5.55e-07 0.382 -0.2030 0.3240 4.91e-03 7.42e-06
Receptor Mediated Mitophagy 11 2.63e-05 4.86e-05 0.819 -0.7760 -0.2630 8.30e-06 1.31e-01
Mitophagy 28 6.80e-06 1.48e-05 0.535 -0.5320 -0.0476 1.07e-06 6.63e-01
Metabolism of amino acids and derivatives 337 1.43e-18 6.85e-18 0.275 -0.1450 0.2340 5.01e-06 1.59e-13
Diseases of carbohydrate metabolism 30 8.99e-03 9.38e-03 0.320 0.3190 -0.0263 2.49e-03 8.03e-01
PTEN Regulation 140 1.48e-08 3.96e-08 0.302 -0.2830 -0.1050 7.59e-09 3.12e-02
Gene Silencing by RNA 95 1.97e-04 2.80e-04 0.250 -0.2410 -0.0668 4.88e-05 2.60e-01
Nucleotide biosynthesis 12 3.67e-03 4.20e-03 0.581 -0.4820 -0.3240 3.83e-03 5.17e-02
Oxidative Stress Induced Senescence 82 2.85e-02 2.85e-02 0.172 -0.1700 -0.0223 7.68e-03 7.26e-01
Mitochondrial biogenesis 91 6.45e-04 8.15e-04 0.239 -0.2230 -0.0841 2.29e-04 1.65e-01
Phospholipid metabolism 186 3.53e-12 1.41e-11 0.319 -0.1470 -0.2830 5.25e-04 2.57e-11
Signaling by the B Cell Receptor (BCR) 106 5.99e-05 1.03e-04 0.255 -0.2340 -0.1020 3.07e-05 6.99e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.75e-03 2.10e-03 0.298 -0.2350 -0.1830 3.34e-03 2.25e-02
Nervous system development 522 8.27e-12 2.83e-11 0.190 -0.1190 -0.1490 3.47e-06 5.53e-09
Metabolism 1856 4.20e-04 5.60e-04 0.057 -0.0501 -0.0270 3.24e-04 5.24e-02
Resolution of D-Loop Structures 33 3.94e-03 4.30e-03 0.350 0.2410 0.2530 1.66e-02 1.18e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.KO s.drug p.KO p.drug
Mucopolysaccharidoses 11 1.36e-05 2.71e-05 0.799 0.7560 -0.2580 1.41e-05 1.38e-01
Reduction of cytosolic Ca++ levels 12 1.99e-04 2.80e-04 0.656 0.4230 -0.5020 1.12e-02 2.59e-03
Mitochondrial iron-sulfur cluster biogenesis 13 1.73e-04 2.77e-04 0.635 -0.4370 0.4620 6.39e-03 3.96e-03
Complex I biogenesis 57 8.21e-22 6.57e-21 0.740 -0.1230 0.7290 1.09e-01 1.49e-21
Respiratory electron transport 103 4.70e-27 5.64e-26 0.610 -0.1600 0.5890 4.90e-03 4.56e-25
Cellular response to starvation 150 2.14e-29 5.15e-28 0.518 -0.3220 0.4060 9.62e-12 9.26e-18
Stabilization of p53 53 9.56e-11 2.87e-10 0.515 -0.4250 0.2910 8.54e-08 2.43e-04
Mitochondrial translation 96 6.75e-20 4.05e-19 0.539 -0.1480 0.5180 1.21e-02 1.55e-18
Mitochondrial protein import 64 2.31e-07 5.55e-07 0.382 -0.2030 0.3240 4.91e-03 7.42e-06
Receptor Mediated Mitophagy 11 2.63e-05 4.86e-05 0.819 -0.7760 -0.2630 8.30e-06 1.31e-01
Mitophagy 28 6.80e-06 1.48e-05 0.535 -0.5320 -0.0476 1.07e-06 6.63e-01
Metabolism of amino acids and derivatives 337 1.43e-18 6.85e-18 0.275 -0.1450 0.2340 5.01e-06 1.59e-13
Diseases of carbohydrate metabolism 30 8.99e-03 9.38e-03 0.320 0.3190 -0.0263 2.49e-03 8.03e-01
PTEN Regulation 140 1.48e-08 3.96e-08 0.302 -0.2830 -0.1050 7.59e-09 3.12e-02
Gene Silencing by RNA 95 1.97e-04 2.80e-04 0.250 -0.2410 -0.0668 4.88e-05 2.60e-01
Nucleotide biosynthesis 12 3.67e-03 4.20e-03 0.581 -0.4820 -0.3240 3.83e-03 5.17e-02
Oxidative Stress Induced Senescence 82 2.85e-02 2.85e-02 0.172 -0.1700 -0.0223 7.68e-03 7.26e-01
Mitochondrial biogenesis 91 6.45e-04 8.15e-04 0.239 -0.2230 -0.0841 2.29e-04 1.65e-01
Phospholipid metabolism 186 3.53e-12 1.41e-11 0.319 -0.1470 -0.2830 5.25e-04 2.57e-11
Signaling by the B Cell Receptor (BCR) 106 5.99e-05 1.03e-04 0.255 -0.2340 -0.1020 3.07e-05 6.99e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.75e-03 2.10e-03 0.298 -0.2350 -0.1830 3.34e-03 2.25e-02
Nervous system development 522 8.27e-12 2.83e-11 0.190 -0.1190 -0.1490 3.47e-06 5.53e-09
Metabolism 1856 4.20e-04 5.60e-04 0.057 -0.0501 -0.0270 3.24e-04 5.24e-02
Resolution of D-Loop Structures 33 3.94e-03 4.30e-03 0.350 0.2410 0.2530 1.66e-02 1.18e-02



Detailed Gene set reports


Mucopolysaccharidoses

Mucopolysaccharidoses
metric value
setSize 11
pMANOVA 1.36e-05
p.adjustMANOVA 2.71e-05
s.dist 0.799
s.KO 0.756
s.drug -0.258
p.KO 1.41e-05
p.drug 0.138




Top 20 genes
Gene KO drug
GNS 11099 -11125
GLB1 10162 -9240
ARSB 12086 -7494
IDS 8178 -10132
GALNS 11751 -6370
NAGLU 12163 -5299
HGSNAT 6442 -3959

Click HERE to show all gene set members

All member genes
KO drug
ARSB 12086 -7494
GALNS 11751 -6370
GLB1 10162 -9240
GNS 11099 -11125
GUSB 9430 8910
HGSNAT 6442 -3959
HYAL1 4794 556
IDS 8178 -10132
IDUA 11538 11620
NAGLU 12163 -5299
SGSH 11466 8231





Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels
metric value
setSize 12
pMANOVA 0.000199
p.adjustMANOVA 0.00028
s.dist 0.656
s.KO 0.423
s.drug -0.502
p.KO 0.0112
p.drug 0.00259




Top 20 genes
Gene KO drug
ATP2A3 12011 -9206
ATP2B4 7929 -11266
SLC8A2 11131 -7612
ATP2A2 7536 -11089
SLC8A3 12029 -6726
CALM1 11329 -6948
ATP2B1 6952 -10931
SLC8A1 10101 -6530
ATP2B2 1355 -2448

Click HERE to show all gene set members

All member genes
KO drug
ATP2A1 -7073 10801
ATP2A2 7536 -11089
ATP2A3 12011 -9206
ATP2B1 6952 -10931
ATP2B2 1355 -2448
ATP2B3 5288 7244
ATP2B4 7929 -11266
CALM1 11329 -6948
SLC8A1 10101 -6530
SLC8A2 11131 -7612
SLC8A3 12029 -6726
SRI -8466 -7625





Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis
metric value
setSize 13
pMANOVA 0.000173
p.adjustMANOVA 0.000277
s.dist 0.635
s.KO -0.437
s.drug 0.462
p.KO 0.00639
p.drug 0.00396




Top 20 genes
Gene KO drug
SLC25A37 -9868 12952
GLRX5 -9519 11726
HSCB -10466 7562
FDX1 -8625 8318
ISCU -6298 10132
FDX2 -5678 10706
LYRM4 -3448 10228
SLC25A28 -2674 12676

Click HERE to show all gene set members

All member genes
KO drug
FDX1 -8625 8318
FDX2 -5678 10706
FDXR 6797 -10
FXN 3001 6244
GLRX5 -9519 11726
HSCB -10466 7562
ISCA1 -7587 -4971
ISCA2 2253 4958
ISCU -6298 10132
LYRM4 -3448 10228
NFS1 -8587 -4816
SLC25A28 -2674 12676
SLC25A37 -9868 12952





Complex I biogenesis

Complex I biogenesis
metric value
setSize 57
pMANOVA 8.21e-22
p.adjustMANOVA 6.57e-21
s.dist 0.74
s.KO -0.123
s.drug 0.729
p.KO 0.109
p.drug 1.49e-21




Top 20 genes
Gene KO drug
NDUFA6 -10640 12901
NDUFB10 -9687 12582
NDUFA8 -8774 12900
NDUFS3 -8653 12725
NDUFB9 -8544 12805
NDUFS8 -7989 12773
NDUFB6 -8238 12165
NDUFAB1 -10558 8746
NDUFV2 -6865 13148
NDUFC1 -7186 12437
NDUFAF4 -8760 9608
NDUFS5 -6394 13145
NDUFV3 -6779 12304
NDUFB11 -7090 11583
NDUFA1 -6222 13127
TMEM126B -8036 9815
NDUFS6 -6327 12108
NDUFA5 -6593 11094
NDUFAF2 -5167 12574
ECSIT -6333 10114

Click HERE to show all gene set members

All member genes
KO drug
ACAD9 12457 11377
COA1 11438 12298
ECSIT -6333 10114
MT-ND1 5209 13177
MT-ND2 -1457 13183
MT-ND3 6571 13181
MT-ND4 566 13174
MT-ND5 4289 13012
MT-ND6 4676 13045
NDUFA1 -6222 13127
NDUFA10 -7241 -4285
NDUFA11 9807 12851
NDUFA12 6720 13048
NDUFA13 -4424 12971
NDUFA2 5937 13125
NDUFA3 -4508 13084
NDUFA5 -6593 11094
NDUFA6 -10640 12901
NDUFA7 8872 13143
NDUFA8 -8774 12900
NDUFA9 2605 10360
NDUFAB1 -10558 8746
NDUFAF1 2883 9463
NDUFAF2 -5167 12574
NDUFAF3 10175 13112
NDUFAF4 -8760 9608
NDUFAF5 -3460 9719
NDUFAF6 -5625 10508
NDUFAF7 6751 8883
NDUFB1 8092 13163
NDUFB10 -9687 12582
NDUFB11 -7090 11583
NDUFB2 11367 12511
NDUFB3 1661 12046
NDUFB4 8888 13008
NDUFB5 -3244 -5075
NDUFB6 -8238 12165
NDUFB7 -4205 12444
NDUFB8 8367 13039
NDUFB9 -8544 12805
NDUFC1 -7186 12437
NDUFC2 -5184 11409
NDUFS1 -9609 -7041
NDUFS2 3967 -10068
NDUFS3 -8653 12725
NDUFS4 6388 3949
NDUFS5 -6394 13145
NDUFS6 -6327 12108
NDUFS7 5531 12411
NDUFS8 -7989 12773
NDUFV1 -5404 8980
NDUFV2 -6865 13148
NDUFV3 -6779 12304
NUBPL 8039 -8010
TIMMDC1 9211 -3329
TMEM126B -8036 9815
TMEM186 -8187 5086





Respiratory electron transport

Respiratory electron transport
metric value
setSize 103
pMANOVA 4.7e-27
p.adjustMANOVA 5.64e-26
s.dist 0.61
s.KO -0.16
s.drug 0.589
p.KO 0.0049
p.drug 4.56e-25




Top 20 genes
Gene KO drug
NDUFA6 -10640 12901
NDUFB10 -9687 12582
COX6B1 -9124 13132
UQCR10 -9028 12920
NDUFA8 -8774 12900
NDUFS3 -8653 12725
NDUFB9 -8544 12805
UQCRH -8039 12733
NDUFS8 -7989 12773
COX20 -9184 10961
NDUFB6 -8238 12165
COX7B -7400 13161
TRAP1 -11197 8602
SCO2 -9739 9526
NDUFAB1 -10558 8746
COX8A -7227 12756
NDUFV2 -6865 13148
NDUFC1 -7186 12437
COX5B -6531 13149
NDUFAF4 -8760 9608

Click HERE to show all gene set members

All member genes
KO drug
ACAD9 12457 11377
COA1 11438 12298
COQ10A 2060 8793
COQ10B -11071 1561
COX11 3872 -3998
COX14 -5296 7054
COX16 -4741 10348
COX18 -7574 -2747
COX19 5255 5188
COX20 -9184 10961
COX4I1 -1716 13016
COX5A 8620 10682
COX5B -6531 13149
COX6A1 -1616 13101
COX6B1 -9124 13132
COX6C 5468 12965
COX7A2L -5446 -8229
COX7B -7400 13161
COX7C 9483 12599
COX8A -7227 12756
CYC1 -8796 9550
CYCS -2044 10884
ECSIT -6333 10114
ETFA -3727 -7917
ETFB -10912 576
ETFDH 2376 356
LRPPRC -7531 -9086
MT-CO1 9067 13178
MT-CO2 8603 13180
MT-CO3 8245 13176
MT-CYB 5991 13184
MT-ND1 5209 13177
MT-ND2 -1457 13183
MT-ND3 6571 13181
MT-ND4 566 13174
MT-ND5 4289 13012
MT-ND6 4676 13045
NDUFA1 -6222 13127
NDUFA10 -7241 -4285
NDUFA11 9807 12851
NDUFA12 6720 13048
NDUFA13 -4424 12971
NDUFA2 5937 13125
NDUFA3 -4508 13084
NDUFA4 9132 11345
NDUFA5 -6593 11094
NDUFA6 -10640 12901
NDUFA7 8872 13143
NDUFA8 -8774 12900
NDUFA9 2605 10360
NDUFAB1 -10558 8746
NDUFAF1 2883 9463
NDUFAF2 -5167 12574
NDUFAF3 10175 13112
NDUFAF4 -8760 9608
NDUFAF5 -3460 9719
NDUFAF6 -5625 10508
NDUFAF7 6751 8883
NDUFB1 8092 13163
NDUFB10 -9687 12582
NDUFB11 -7090 11583
NDUFB2 11367 12511
NDUFB3 1661 12046
NDUFB4 8888 13008
NDUFB5 -3244 -5075
NDUFB6 -8238 12165
NDUFB7 -4205 12444
NDUFB8 8367 13039
NDUFB9 -8544 12805
NDUFC1 -7186 12437
NDUFC2 -5184 11409
NDUFS1 -9609 -7041
NDUFS2 3967 -10068
NDUFS3 -8653 12725
NDUFS4 6388 3949
NDUFS5 -6394 13145
NDUFS6 -6327 12108
NDUFS7 5531 12411
NDUFS8 -7989 12773
NDUFV1 -5404 8980
NDUFV2 -6865 13148
NDUFV3 -6779 12304
NUBPL 8039 -8010
SCO1 -10631 -6537
SCO2 -9739 9526
SDHA -10480 -9986
SDHB -299 5982
SDHC 9345 -5559
SDHD -9641 -2716
SURF1 8003 9112
TACO1 8239 8081
TIMMDC1 9211 -3329
TMEM126B -8036 9815
TMEM186 -8187 5086
TRAP1 -11197 8602
UQCR10 -9028 12920
UQCR11 -5675 11509
UQCRB -979 12923
UQCRC1 8588 -1762
UQCRC2 -11089 -6026
UQCRFS1 -10915 -8657
UQCRH -8039 12733
UQCRQ 10244 13147





Cellular response to starvation

Cellular response to starvation
metric value
setSize 150
pMANOVA 2.14e-29
p.adjustMANOVA 5.15e-28
s.dist 0.518
s.KO -0.322
s.drug 0.406
p.KO 9.62e-12
p.drug 9.26e-18




Top 20 genes
Gene KO drug
ASNS -10878 12349
RPL22L1 -10448 12221
RPL9 -9659 12806
ATP6V1F -9621 12853
RPS17 -10534 11631
RPL34 -9357 12996
RPL12 -9329 12992
RPL26L1 -9387 12770
RPS13 -9450 12652
RPS25 -9371 12690
RPL37A -9347 12675
RPS18 -9122 12984
RPL17 -8989 12909
TCIRG1 -9563 12083
RPL31 -8781 13131
RPS6 -9225 12405
RPS15A -8754 12989
RPL36 -8818 12868
FAU -8610 13102
RPL26 -8797 12658

Click HERE to show all gene set members

All member genes
KO drug
ASNS -10878 12349
ATF2 -8942 -9289
ATF3 -4081 -4353
ATF4 -6768 11948
ATP6V0B -8190 12175
ATP6V0C -8240 10022
ATP6V0D1 11801 -8213
ATP6V0D2 -9542 2965
ATP6V0E1 -8440 12436
ATP6V0E2 12829 7103
ATP6V1A 9802 -8760
ATP6V1B1 8282 12811
ATP6V1B2 -11084 -9848
ATP6V1C1 8273 -8400
ATP6V1C2 3667 10275
ATP6V1D 2442 246
ATP6V1E1 -8985 -897
ATP6V1E2 9261 830
ATP6V1F -9621 12853
ATP6V1G1 -5949 11369
ATP6V1G2 8440 1464
ATP6V1H 8359 -481
BMT2 -8111 -8436
CEBPB -7116 12656
CEBPG -9940 6581
DDIT3 -9395 10987
DEPDC5 -57 -3609
EIF2AK4 10865 -7766
EIF2S1 -8950 -8774
EIF2S2 -10653 -6089
EIF2S3 -10174 -5022
FAU -8610 13102
FLCN -11166 -4240
FNIP1 -10267 -9342
FNIP2 4906 -9706
GCN1 10665 -8257
IMPACT -1732 -8127
ITFG2 9671 12398
KPTN 8095 10246
LAMTOR1 -5671 -7722
LAMTOR2 5420 10180
LAMTOR3 -2587 6218
LAMTOR4 -8066 10839
LAMTOR5 6245 11081
MIOS -9468 -7857
MLST8 -10314 -4897
MTOR 8963 -5908
NPRL2 -5122 12562
NPRL3 -10528 4401
RHEB 11691 4362
RPL10 -3821 1597
RPL10A -9707 -8212
RPL11 -8529 12382
RPL12 -9329 12992
RPL13 -3469 12598
RPL13A -6854 6955
RPL14 -6386 13137
RPL15 -786 12153
RPL17 -8989 12909
RPL18 -6672 12800
RPL18A -6976 11926
RPL19 3924 12911
RPL21 -6322 5141
RPL22 -5554 9520
RPL22L1 -10448 12221
RPL23 5769 12922
RPL23A 11361 -5257
RPL24 -4591 12995
RPL26 -8797 12658
RPL26L1 -9387 12770
RPL27 6735 11625
RPL27A -7818 13051
RPL28 -5809 12962
RPL29 -4515 12915
RPL3 -6827 -4535
RPL30 -3907 11096
RPL31 -8781 13131
RPL32 -5028 12983
RPL34 -9357 12996
RPL35 -8027 13097
RPL35A -1449 12789
RPL36 -8818 12868
RPL36A -4480 13009
RPL36AL -8216 12702
RPL37 -4624 13134
RPL37A -9347 12675
RPL38 1558 13140
RPL39 -6168 11962
RPL39L -6608 -6269
RPL3L -510 7904
RPL4 11351 12558
RPL41 -4616 -6074
RPL5 4679 12075
RPL6 -6903 12730
RPL7 -3327 -8789
RPL7A -6163 11708
RPL8 -7572 10323
RPL9 -9659 12806
RPLP0 -1504 -7331
RPLP1 9026 12731
RPLP2 -8225 12999
RPS10 -8384 10665
RPS11 -7725 12935
RPS12 -7872 11600
RPS13 -9450 12652
RPS14 -1180 12428
RPS15 -7430 12908
RPS15A -8754 12989
RPS16 -3844 12941
RPS17 -10534 11631
RPS18 -9122 12984
RPS19 -7633 12888
RPS2 -10222 8916
RPS20 -4961 13095
RPS21 -3001 13022
RPS23 6940 11907
RPS24 2369 13034
RPS25 -9371 12690
RPS26 -2615 13114
RPS27 651 11270
RPS27A 5357 6464
RPS27L 7330 12750
RPS28 2716 12485
RPS29 -652 9078
RPS3 -7756 12135
RPS3A -9170 5257
RPS4X -8542 12239
RPS5 -6283 -7965
RPS6 -9225 12405
RPS7 5142 12976
RPS8 -5812 12745
RPS9 -8815 10189
RPSA 292 11576
RPTOR 10601 -4826
RRAGA 11570 -7681
RRAGB -3038 4672
RRAGC -10787 -9790
RRAGD -5240 -9110
SEC13 -9702 -8646
SEH1L -9333 -5653
SESN1 7728 -4176
SESN2 -6559 -3744
SH3BP4 -10917 -10437
SLC38A9 10703 -7126
SZT2 11569 6561
TCIRG1 -9563 12083
TRIB3 -3221 -5552
UBA52 -6807 11639
WDR24 -10330 -7421
WDR59 -6083 10675





Stabilization of p53

Stabilization of p53
metric value
setSize 53
pMANOVA 9.56e-11
p.adjustMANOVA 2.87e-10
s.dist 0.515
s.KO -0.425
s.drug 0.291
p.KO 8.54e-08
p.drug 0.000243




Top 20 genes
Gene KO drug
CHEK2 -10879 12367
SEM1 -9978 13108
PSMA4 -9907 11447
PSMB8 -9783 11153
PSMB7 -8656 12462
PSMB9 -9810 10733
PSME1 -8654 11878
PSMA1 -9646 10578
PSMC2 -9185 11068
PSMD6 -7577 12228
PSMC4 -7156 12714
PSMD14 -10615 8461
UBA52 -6807 11639
PSMB1 -6139 12480
UBC -10397 7017
PSMB6 -6537 10901
PSMA3 -5668 12561
UBB -5602 12024
PSMD13 -5300 12140
PSME2 -4231 12869

Click HERE to show all gene set members

All member genes
KO drug
ATM -300 -6012
CHEK2 -10879 12367
MDM2 -3386 -5606
MDM4 3213 10020
PHF20 -6735 -9542
PSMA1 -9646 10578
PSMA2 -4002 -4430
PSMA3 -5668 12561
PSMA4 -9907 11447
PSMA5 5538 826
PSMA6 -3328 8997
PSMA7 -10164 -7607
PSMB1 -6139 12480
PSMB10 9537 11663
PSMB2 -3364 8976
PSMB3 7905 13078
PSMB4 -1370 12998
PSMB5 -6937 -2970
PSMB6 -6537 10901
PSMB7 -8656 12462
PSMB8 -9783 11153
PSMB9 -9810 10733
PSMC1 -3547 -3814
PSMC2 -9185 11068
PSMC3 -1273 12327
PSMC4 -7156 12714
PSMC5 7024 12041
PSMC6 -7069 697
PSMD1 -9192 -10441
PSMD10 -6869 1286
PSMD11 7720 -8518
PSMD12 813 8775
PSMD13 -5300 12140
PSMD14 -10615 8461
PSMD2 -6801 -10378
PSMD3 -8058 -4798
PSMD4 743 11756
PSMD5 -9642 -8039
PSMD6 -7577 12228
PSMD7 -6198 -6043
PSMD8 -9103 -6526
PSMD9 -7638 -3346
PSME1 -8654 11878
PSME2 -4231 12869
PSME3 11811 -7813
PSME4 -10581 -10843
PSMF1 -7549 -4369
RPS27A 5357 6464
SEM1 -9978 13108
TP53 -3433 10144
UBA52 -6807 11639
UBB -5602 12024
UBC -10397 7017





Mitochondrial translation

Mitochondrial translation
metric value
setSize 96
pMANOVA 6.75e-20
p.adjustMANOVA 4.05e-19
s.dist 0.539
s.KO -0.148
s.drug 0.518
p.KO 0.0121
p.drug 1.55e-18




Top 20 genes
Gene KO drug
MRPL32 -10161 13017
MRPL2 -10512 12505
MRPS26 -10158 12585
MRPL18 -8000 12866
MRPS34 -10296 9793
GADD45GIP1 -7299 13128
MRPL17 -7520 12273
MRPL34 -7095 13003
MRPL50 -8242 10992
MRPL48 -7125 12684
MRPL41 -6895 12960
MRPL28 -7301 11637
MRPL46 -9488 8908
TUFM -8420 9886
MRPL21 -6454 12815
MRPL14 -6840 11982
MRPL36 -9849 8266
MRPS5 -9234 8657
MRPL39 -7339 10642
MRPS24 -7478 10207

Click HERE to show all gene set members

All member genes
KO drug
AURKAIP1 -133 12408
CHCHD1 9131 12380
DAP3 -3752 -565
ERAL1 10004 6656
GADD45GIP1 -7299 13128
GFM1 10740 -9692
GFM2 12241 -9673
MRPL1 7835 12136
MRPL10 7038 -3968
MRPL11 -5116 12062
MRPL12 3449 11754
MRPL13 6295 1716
MRPL14 -6840 11982
MRPL15 -7055 7319
MRPL16 6138 12765
MRPL17 -7520 12273
MRPL18 -8000 12866
MRPL19 -4724 8112
MRPL2 -10512 12505
MRPL20 -3240 12687
MRPL21 -6454 12815
MRPL22 -4827 13106
MRPL23 7423 13081
MRPL24 -1564 13063
MRPL27 9389 12972
MRPL28 -7301 11637
MRPL3 -4483 -1670
MRPL30 -4144 -2207
MRPL32 -10161 13017
MRPL33 10926 3035
MRPL34 -7095 13003
MRPL35 -2774 11796
MRPL36 -9849 8266
MRPL37 -4668 -8699
MRPL38 -373 12488
MRPL39 -7339 10642
MRPL4 -8120 1791
MRPL40 -463 12827
MRPL41 -6895 12960
MRPL42 2461 7413
MRPL43 7257 10836
MRPL44 -10349 -1148
MRPL45 6164 -7914
MRPL46 -9488 8908
MRPL47 4811 12879
MRPL48 -7125 12684
MRPL49 -9816 -6045
MRPL50 -8242 10992
MRPL51 -2027 11363
MRPL52 10778 12795
MRPL53 10106 12803
MRPL54 -4543 12461
MRPL55 4836 12563
MRPL57 10690 13103
MRPL58 -3957 11786
MRPL9 -3209 -1926
MRPS10 -5700 -5579
MRPS11 -8163 -2495
MRPS12 -8848 3670
MRPS14 6215 9031
MRPS15 812 13085
MRPS16 8903 9672
MRPS17 945 11882
MRPS18A -417 -1247
MRPS18B -10430 2240
MRPS18C -6186 11495
MRPS2 1748 -9247
MRPS21 7114 13135
MRPS22 -6687 10137
MRPS23 -2639 4213
MRPS24 -7478 10207
MRPS25 2659 12502
MRPS26 -10158 12585
MRPS27 10588 -8389
MRPS28 9220 11844
MRPS30 -10503 -7448
MRPS31 -3496 12760
MRPS33 10443 10599
MRPS34 -10296 9793
MRPS35 -10292 -5066
MRPS36 7958 12481
MRPS5 -9234 8657
MRPS6 -10724 -4569
MRPS7 10093 8378
MRPS9 -5672 10173
MRRF 3892 10977
MT-RNR1 -5225 13169
MT-RNR2 -1383 13168
MTFMT -4746 1913
MTIF2 7857 -2173
MTIF3 -4102 9943
MTRF1L -6090 -3388
OXA1L 12157 10649
PTCD3 4329 10448
TSFM -5098 12110
TUFM -8420 9886





Mitochondrial protein import

Mitochondrial protein import
metric value
setSize 64
pMANOVA 2.31e-07
p.adjustMANOVA 5.55e-07
s.dist 0.382
s.KO -0.203
s.drug 0.324
p.KO 0.00491
p.drug 7.42e-06




Top 20 genes
Gene KO drug
TOMM5 -10851 12880
TIMM44 -10857 12491
PAM16 -9772 13044
BCS1L -10585 11357
TIMM50 -9302 12450
MTX2 -10384 10819
TIMM23 -8696 12559
TOMM6 -9125 11669
COA6 -8675 11732
TIMM17B -7733 11392
TIMM21 -8728 9796
CMC2 -7214 11734
CYC1 -8796 9550
HSCB -10466 7562
TOMM22 -9961 7884
TIMM9 -7007 10249
TOMM40 -5273 12204
TIMM8B -4807 12754
CMC4 -6934 8412
CHCHD5 -5991 9413

Click HERE to show all gene set members

All member genes
KO drug
ACO2 -5040 -2386
ATP5F1A 7998 -9624
ATP5F1B -8379 -9015
ATP5MC1 10755 12985
BCS1L -10585 11357
CHCHD10 -2946 13055
CHCHD2 -7471 -405
CHCHD3 10648 -7217
CHCHD4 -5788 6594
CHCHD5 -5991 9413
CHCHD7 9814 10158
CMC2 -7214 11734
CMC4 -6934 8412
COA4 -4380 9960
COA6 -8675 11732
COQ2 2965 10768
COX17 11802 13107
COX19 5255 5188
CS -9273 -10545
CYC1 -8796 9550
DNAJC19 9162 12416
FXN 3001 6244
GFER -7333 -2348
GRPEL1 -4676 2992
GRPEL2 -6217 -6186
HSCB -10466 7562
HSPA9 -6955 6549
HSPD1 -11419 4333
IDH3G 117 9128
LDHD 11695 -6379
MTX1 10553 11989
MTX2 -10384 10819
NDUFB8 8367 13039
PAM16 -9772 13044
PITRM1 -10074 -7430
PMPCA 4049 6598
PMPCB -8267 -7717
SAMM50 -10241 -5933
SLC25A12 9436 5342
SLC25A13 12236 -4102
SLC25A4 1734 -880
SLC25A6 2241 -1082
TAZ 8218 12600
TIMM10 -55 11810
TIMM10B 7893 4410
TIMM13 7282 11742
TIMM17A -5359 -7898
TIMM17B -7733 11392
TIMM21 -8728 9796
TIMM22 569 7666
TIMM23 -8696 12559
TIMM44 -10857 12491
TIMM50 -9302 12450
TIMM8A 2366 -141
TIMM8B -4807 12754
TIMM9 -7007 10249
TOMM20 -2506 -10139
TOMM22 -9961 7884
TOMM40 -5273 12204
TOMM5 -10851 12880
TOMM6 -9125 11669
TOMM7 1259 -5484
TOMM70 2104 -9721
VDAC1 10321 -414





Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
metric value
setSize 11
pMANOVA 2.63e-05
p.adjustMANOVA 4.86e-05
s.dist 0.819
s.KO -0.776
s.drug -0.263
p.KO 8.3e-06
p.drug 0.131




Top 20 genes
Gene KO drug
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
SRC -11388 -7284
ULK1 -10494 -7342
ATG5 -7565 -7228
PGAM5 -10817 -4475
ATG12 -4585 -5690
MAP1LC3B -9817 -1760

Click HERE to show all gene set members

All member genes
KO drug
ATG12 -4585 -5690
ATG5 -7565 -7228
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
CSNK2B -9249 12011
FUNDC1 -3096 9106
MAP1LC3A -9431 8671
MAP1LC3B -9817 -1760
PGAM5 -10817 -4475
SRC -11388 -7284
ULK1 -10494 -7342





Mitophagy

Mitophagy
metric value
setSize 28
pMANOVA 6.8e-06
p.adjustMANOVA 1.48e-05
s.dist 0.535
s.KO -0.532
s.drug -0.0476
p.KO 1.07e-06
p.drug 0.663




Top 20 genes
Gene KO drug
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
SRC -11388 -7284
PINK1 -9731 -8514
ULK1 -10494 -7342
MFN2 -8641 -8214
SQSTM1 -9459 -6901
ATG5 -7565 -7228
PGAM5 -10817 -4475
ATG12 -4585 -5690
TOMM20 -2506 -10139
MAP1LC3B -9817 -1760

Click HERE to show all gene set members

All member genes
KO drug
ATG12 -4585 -5690
ATG5 -7565 -7228
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
CSNK2B -9249 12011
FUNDC1 -3096 9106
MAP1LC3A -9431 8671
MAP1LC3B -9817 -1760
MFN1 9655 -9134
MFN2 -8641 -8214
MTERF3 -6727 11913
PGAM5 -10817 -4475
PINK1 -9731 -8514
RPS27A 5357 6464
SQSTM1 -9459 -6901
SRC -11388 -7284
TOMM20 -2506 -10139
TOMM22 -9961 7884
TOMM40 -5273 12204
TOMM5 -10851 12880
TOMM6 -9125 11669
TOMM7 1259 -5484
TOMM70 2104 -9721
UBA52 -6807 11639
UBB -5602 12024
UBC -10397 7017
ULK1 -10494 -7342
VDAC1 10321 -414





Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives
metric value
setSize 337
pMANOVA 1.43e-18
p.adjustMANOVA 6.85e-18
s.dist 0.275
s.KO -0.145
s.drug 0.234
p.KO 5.01e-06
p.drug 1.59e-13




Top 20 genes
Gene KO drug
ASNS -10878 12349
SEM1 -9978 13108
ECHS1 -11411 11233
RPL22L1 -10448 12221
PDHA1 -10664 11842
RPL9 -9659 12806
RPS17 -10534 11631
RPL34 -9357 12996
RPL12 -9329 12992
RPL26L1 -9387 12770
RPS13 -9450 12652
RPS25 -9371 12690
RPL37A -9347 12675
RPS18 -9122 12984
RPL17 -8989 12909
RPL31 -8781 13131
RPS6 -9225 12405
RPS15A -8754 12989
RPL36 -8818 12868
PSMA4 -9907 11447

Click HERE to show all gene set members

All member genes
KO drug
AADAT 10672 7274
AANAT 12010 -5836
AASS -2035 -7338
ACAD8 11347 11473
ACADSB 8386 4523
ACAT1 -10638 -4238
ADI1 -3579 9094
ADO 6777 -9156
AFMID -4671 7924
AGMAT 994 328
AHCY 1345 629
AIMP1 -9006 1838
AIMP2 1872 -2032
ALDH18A1 -8886 -10473
ALDH4A1 11146 -3790
ALDH6A1 -7224 -8331
ALDH7A1 10593 11100
ALDH9A1 -560 -6258
AMD1 -9021 -9915
AMDHD1 11155 6105
AMT 6745 8913
APIP -5270 9958
ARG1 1715 -1184
ARG2 -11492 -11033
ASL 12501 5148
ASNS -10878 12349
ASPA 5403 1602
ASRGL1 9236 582
ASS1 11521 -1872
AUH 5719 5062
AZIN1 -8879 -10550
AZIN2 3795 3688
BCAT1 -7644 -9371
BCAT2 -6548 8118
BCKDHA 8458 -10040
BCKDHB 10575 160
BCKDK -4165 -6907
BHMT -547 5797
BHMT2 12451 10224
CARNMT1 -7382 -7203
CARNS1 6990 326
CBS 10907 11159
CBSL -586 5098
CGA 4785 2191
CHDH 12135 8784
CKB 11133 11188
CKM -2654 386
CKMT1A 10958 11903
CKMT2 4895 -1910
CPS1 -10630 6101
CRYM -7062 2482
CSAD -3233 12728
CTH -3063 -3718
DARS1 -10008 4483
DBH 9900 -1549
DBT -3782 -8648
DCT -3537 2001
DDO 2059 -137
DHTKD1 -1810 -8372
DIO2 -8254 8806
DLAT -8123 -7745
DLD -9253 -8294
DLST -8194 -10831
DMGDH 9315 3116
DUOX1 6936 -3160
DUOX2 1184 -269
ECHS1 -11411 11233
EEF1E1 -10204 1084
EEFSEC 11184 -3492
ENOPH1 -10785 1785
EPRS1 1368 -10895
ETHE1 -10431 -6139
FAH -6674 8819
FAU -8610 13102
FOLH1 -7523 445
FTCD 6855 10549
GADL1 -795 -1006
GAMT 11210 12230
GATM 11947 -7095
GCAT -10028 11163
GCDH 6035 9903
GCSH -6761 9913
GLDC 4017 -7420
GLS -9356 -8809
GLS2 9366 2679
GLUD1 -9514 -10318
GLUD2 -5197 -4510
GLUL 12531 -9935
GNMT -1375 5139
GOT1 -251 7784
GOT2 11173 841
GPT 8865 9142
GPT2 8365 7519
GRHPR -6215 8320
GSR -11433 -4996
GSTZ1 10777 8707
HAAO 8688 9133
HAL -3269 4475
HIBADH 2089 8513
HIBCH -2666 969
HNMT -1649 3699
HOGA1 1298 5341
HPD 1912 5180
HSD17B10 2620 11931
HYKK -4392 9854
IARS1 -2182 -9570
IDO2 4265 2865
IL4I1 -11099 -4396
INMT 9444 -4952
IVD 12121 -4420
IYD -351 5080
KARS1 -10243 9778
KMO 7390 6829
KYAT1 -5720 2274
KYAT3 10416 -9152
KYNU -2499 6757
LARS1 -7999 -5859
LIAS -9105 5143
LIPT1 -8180 2538
LIPT2 -2271 5033
MARS1 -1476 10979
MAT1A -6091 2828
MCCC1 12225 -6790
MCCC2 8284 -1797
MPST -4372 12019
MRI1 -8262 9899
MTAP 5134 6545
MTR 92 -9742
MTRR -8284 -8513
NAALAD2 7668 8036
NAGS 11887 -8985
NAT8L -4195 -9350
NDUFAB1 -10558 8746
NMRAL1 -6580 12010
NNMT 12760 12864
NQO1 12497 12065
OAT 10923 -3605
OAZ1 -5995 8537
OAZ2 12305 -4736
OAZ3 -4681 -2934
OCA2 11312 -5329
ODC1 -11548 -8715
OGDH -5384 -7828
PAOX 10273 -5165
PAPSS1 -10307 -3927
PAPSS2 6847 -10771
PCBD1 10442 9074
PDHA1 -10664 11842
PDHB -3368 12152
PDHX -9039 -4928
PHGDH 10381 12550
PHYKPL 12650 4336
PIPOX 3326 -2663
PNMT 6175 5951
PPM1K -9252 -7689
PRODH 4648 8935
PSAT1 -8575 11575
PSMA1 -9646 10578
PSMA2 -4002 -4430
PSMA3 -5668 12561
PSMA4 -9907 11447
PSMA5 5538 826
PSMA6 -3328 8997
PSMA7 -10164 -7607
PSMB1 -6139 12480
PSMB10 9537 11663
PSMB2 -3364 8976
PSMB3 7905 13078
PSMB4 -1370 12998
PSMB5 -6937 -2970
PSMB6 -6537 10901
PSMB7 -8656 12462
PSMB8 -9783 11153
PSMB9 -9810 10733
PSMC1 -3547 -3814
PSMC2 -9185 11068
PSMC3 -1273 12327
PSMC4 -7156 12714
PSMC5 7024 12041
PSMC6 -7069 697
PSMD1 -9192 -10441
PSMD10 -6869 1286
PSMD11 7720 -8518
PSMD12 813 8775
PSMD13 -5300 12140
PSMD14 -10615 8461
PSMD2 -6801 -10378
PSMD3 -8058 -4798
PSMD4 743 11756
PSMD5 -9642 -8039
PSMD6 -7577 12228
PSMD7 -6198 -6043
PSMD8 -9103 -6526
PSMD9 -7638 -3346
PSME1 -8654 11878
PSME2 -4231 12869
PSME3 11811 -7813
PSME4 -10581 -10843
PSMF1 -7549 -4369
PSPH 11422 7040
PSTK 5756 9314
PXMP2 10630 4583
PYCR1 -4927 -11012
PYCR2 9765 12269
QARS1 10134 -6688
QDPR 11360 -6120
RARS1 -9720 -7252
RIDA -72 11337
RIMKLA 12748 -8994
RIMKLB -8314 347
RPL10 -3821 1597
RPL10A -9707 -8212
RPL11 -8529 12382
RPL12 -9329 12992
RPL13 -3469 12598
RPL13A -6854 6955
RPL14 -6386 13137
RPL15 -786 12153
RPL17 -8989 12909
RPL18 -6672 12800
RPL18A -6976 11926
RPL19 3924 12911
RPL21 -6322 5141
RPL22 -5554 9520
RPL22L1 -10448 12221
RPL23 5769 12922
RPL23A 11361 -5257
RPL24 -4591 12995
RPL26 -8797 12658
RPL26L1 -9387 12770
RPL27 6735 11625
RPL27A -7818 13051
RPL28 -5809 12962
RPL29 -4515 12915
RPL3 -6827 -4535
RPL30 -3907 11096
RPL31 -8781 13131
RPL32 -5028 12983
RPL34 -9357 12996
RPL35 -8027 13097
RPL35A -1449 12789
RPL36 -8818 12868
RPL36A -4480 13009
RPL36AL -8216 12702
RPL37 -4624 13134
RPL37A -9347 12675
RPL38 1558 13140
RPL39 -6168 11962
RPL39L -6608 -6269
RPL3L -510 7904
RPL4 11351 12558
RPL41 -4616 -6074
RPL5 4679 12075
RPL6 -6903 12730
RPL7 -3327 -8789
RPL7A -6163 11708
RPL8 -7572 10323
RPL9 -9659 12806
RPLP0 -1504 -7331
RPLP1 9026 12731
RPLP2 -8225 12999
RPS10 -8384 10665
RPS11 -7725 12935
RPS12 -7872 11600
RPS13 -9450 12652
RPS14 -1180 12428
RPS15 -7430 12908
RPS15A -8754 12989
RPS16 -3844 12941
RPS17 -10534 11631
RPS18 -9122 12984
RPS19 -7633 12888
RPS2 -10222 8916
RPS20 -4961 13095
RPS21 -3001 13022
RPS23 6940 11907
RPS24 2369 13034
RPS25 -9371 12690
RPS26 -2615 13114
RPS27 651 11270
RPS27A 5357 6464
RPS27L 7330 12750
RPS28 2716 12485
RPS29 -652 9078
RPS3 -7756 12135
RPS3A -9170 5257
RPS4X -8542 12239
RPS5 -6283 -7965
RPS6 -9225 12405
RPS7 5142 12976
RPS8 -5812 12745
RPS9 -8815 10189
RPSA 292 11576
SARDH 11797 -2513
SARS1 10748 -9421
SAT1 -11516 8580
SCLY -9481 10671
SDS 3809 3212
SDSL 11650 4044
SECISBP2 11207 -6517
SEM1 -9978 13108
SEPHS2 8103 -351
SEPSECS -6443 -5096
SERINC1 -8559 -10927
SERINC2 12901 -4299
SERINC3 -9690 -10718
SERINC5 -10855 -10123
SHMT1 10041 12191
SLC25A10 10535 10876
SLC25A12 9436 5342
SLC25A13 12236 -4102
SLC25A15 -8051 -6219
SLC25A21 1939 -353
SLC25A44 8439 -6942
SLC36A4 -1600 -8668
SLC3A2 -9319 -3436
SLC44A1 3030 -8195
SLC5A5 5760 4246
SLC6A11 10785 -3525
SLC6A12 -4244 1206
SLC6A8 12417 -9058
SLC7A5 -9076 -4839
SMOX -3994 -11021
SMS -11167 -1993
SRM -7150 11902
SRR -6159 7210
SUOX 11819 9645
TAT 4699 448
TDO2 8914 5887
TMLHE 10560 -7649
TPH1 3976 9198
TPH2 -308 7806
TPO 4072 7357
TST 9957 10661
TXN2 -8694 3274
TXNRD1 -10964 -9955
UBA52 -6807 11639





Diseases of carbohydrate metabolism

Diseases of carbohydrate metabolism
metric value
setSize 30
pMANOVA 0.00899
p.adjustMANOVA 0.00938
s.dist 0.32
s.KO 0.319
s.drug -0.0263
p.KO 0.00249
p.drug 0.803




Top 20 genes
Gene KO drug
GBE1 12790 -10994
GNS 11099 -11125
GLB1 10162 -9240
GYG1 10629 -8829
ARSB 12086 -7494
IDS 8178 -10132
GAA 12540 -6361
GALNS 11751 -6370
NAGLU 12163 -5299
PPP1R3C 10573 -5635
HGSNAT 6442 -3959
GYG2 10117 -1505
KHK 6482 -1164
ALDOB 2760 -1433

Click HERE to show all gene set members

All member genes
KO drug
ALDOB 2760 -1433
ARSB 12086 -7494
DCXR -6370 12401
EPM2A -7152 2522
G6PC3 11270 11945
GAA 12540 -6361
GALNS 11751 -6370
GBE1 12790 -10994
GLB1 10162 -9240
GNS 11099 -11125
GUSB 9430 8910
GYG1 10629 -8829
GYG2 10117 -1505
GYS1 -8713 -8373
HGSNAT 6442 -3959
HYAL1 4794 556
IDS 8178 -10132
IDUA 11538 11620
KHK 6482 -1164
NAGLU 12163 -5299
NHLRC1 9210 6494
PPP1R3C 10573 -5635
RPIA -1807 -4134
RPS27A 5357 6464
SGSH 11466 8231
SLC37A4 -6962 9471
TALDO1 -9895 11544
UBA52 -6807 11639
UBB -5602 12024
UBC -10397 7017





PTEN Regulation

PTEN Regulation
metric value
setSize 140
pMANOVA 1.48e-08
p.adjustMANOVA 3.96e-08
s.dist 0.302
s.KO -0.283
s.drug -0.105
p.KO 7.59e-09
p.drug 0.0312




Top 20 genes
Gene KO drug
AGO2 -10824 -10899
PSME4 -10581 -10843
CSNK2A1 -10604 -10586
TNKS -11005 -10107
RCOR1 -10367 -10614
USP7 -11306 -9522
REST -10029 -10671
RRAGC -10787 -9790
CSNK2A2 -9949 -10332
GATAD2B -9311 -10855
MAPK1 -9173 -10906
PSMD1 -9192 -10441
KDM1A -10032 -9331
TNRC6B -10673 -8745
MAPK3 -9742 -9271
GATAD2A -11048 -7912
VAPA -10099 -8584
HDAC5 -9547 -9053
AGO3 -9916 -8382
ATF2 -8942 -9289

Click HERE to show all gene set members

All member genes
KO drug
AGO1 -7681 -6719
AGO2 -10824 -10899
AGO3 -9916 -8382
AGO4 8566 -7725
AKT1 -1733 -1215
AKT2 9732 3410
AKT3 6626 -10834
ATF2 -8942 -9289
ATN1 -5130 -6152
BMI1 -6365 -9563
CBX2 8151 -5128
CBX4 5239 -5196
CBX6 -5993 -5822
CBX8 8308 10487
CHD3 -5284 -8323
CHD4 -4510 -10191
CNOT6L -8358 -9361
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
CSNK2B -9249 12011
EED -8207 -1581
EGR1 -11412 4407
EZH2 11841 12709
FRK 6214 -2830
GATAD2A -11048 -7912
GATAD2B -9311 -10855
HDAC1 -5601 11449
HDAC2 -9786 -6704
HDAC3 10500 -7476
HDAC5 -9547 -9053
HDAC7 7031 -8451
JUN 12224 6311
KDM1A -10032 -9331
LAMTOR1 -5671 -7722
LAMTOR2 5420 10180
LAMTOR3 -2587 6218
LAMTOR4 -8066 10839
LAMTOR5 6245 11081
MAF1 -7678 -3960
MAPK1 -9173 -10906
MAPK3 -9742 -9271
MBD3 -6720 12289
MECOM 11240 -6980
MKRN1 12553 -9976
MLST8 -10314 -4897
MOV10 6666 10563
MTA1 -5679 10842
MTA2 -8669 5527
MTA3 654 10406
MTOR 8963 -5908
NEDD4 11639 -9004
NR2E1 -482 -911
OTUD3 -10780 -6953
PHC1 8769 4837
PHC2 11301 -9451
PHC3 -7418 -9924
PML -5371 -6979
PPARG 12799 9364
PREX2 10194 -4586
PSMA1 -9646 10578
PSMA2 -4002 -4430
PSMA3 -5668 12561
PSMA4 -9907 11447
PSMA5 5538 826
PSMA6 -3328 8997
PSMA7 -10164 -7607
PSMB1 -6139 12480
PSMB10 9537 11663
PSMB2 -3364 8976
PSMB3 7905 13078
PSMB4 -1370 12998
PSMB5 -6937 -2970
PSMB6 -6537 10901
PSMB7 -8656 12462
PSMB8 -9783 11153
PSMB9 -9810 10733
PSMC1 -3547 -3814
PSMC2 -9185 11068
PSMC3 -1273 12327
PSMC4 -7156 12714
PSMC5 7024 12041
PSMC6 -7069 697
PSMD1 -9192 -10441
PSMD10 -6869 1286
PSMD11 7720 -8518
PSMD12 813 8775
PSMD13 -5300 12140
PSMD14 -10615 8461
PSMD2 -6801 -10378
PSMD3 -8058 -4798
PSMD4 743 11756
PSMD5 -9642 -8039
PSMD6 -7577 12228
PSMD7 -6198 -6043
PSMD8 -9103 -6526
PSMD9 -7638 -3346
PSME1 -8654 11878
PSME2 -4231 12869
PSME3 11811 -7813
PSME4 -10581 -10843
PSMF1 -7549 -4369
PTEN -6933 -8533
PTENP1 -7139 -534
RBBP4 -5569 -4482
RBBP7 -7044 -6256
RCOR1 -10367 -10614
REST -10029 -10671
RHEB 11691 4362
RING1 -3031 11489
RNF146 2285 1860
RNF2 -7038 -9730
RPS27A 5357 6464
RPTOR 10601 -4826
RRAGA 11570 -7681
RRAGB -3038 4672
RRAGC -10787 -9790
RRAGD -5240 -9110
SALL4 -2003 12606
SCMH1 7811 6193
SEM1 -9978 13108
SLC38A9 10703 -7126
SNAI1 -521 -4976
SNAI2 -6452 -6811
STUB1 -10050 1054
SUZ12 -10605 9924
TNKS -11005 -10107
TNKS2 6087 -11079
TNRC6A 2904 -5402
TNRC6B -10673 -8745
TNRC6C -5035 -5659
TP53 -3433 10144
TRIM27 -8330 -9054
UBA52 -6807 11639
UBB -5602 12024
UBC -10397 7017
USP13 4677 -8544
USP7 -11306 -9522
VAPA -10099 -8584
WWP2 10930 -5526
XIAP -5888 -8812





Gene Silencing by RNA

Gene Silencing by RNA
metric value
setSize 95
pMANOVA 0.000197
p.adjustMANOVA 0.00028
s.dist 0.25
s.KO -0.241
s.drug -0.0668
p.KO 4.88e-05
p.drug 0.26




Top 20 genes
Gene KO drug
POLR2A -11346 -10737
AGO2 -10824 -10899
NUP98 -10847 -10135
NUP160 -10172 -9854
TNRC6B -10673 -8745
POLR2B -9710 -9575
XPO5 -11181 -7902
NUP54 -10563 -8348
NUP153 -8447 -10433
POM121 -8878 -9749
POM121C -9406 -9089
SEC13 -9702 -8646
AGO3 -9916 -8382
PRKRA -11124 -6874
NUP58 -7370 -10308
RANBP2 -5941 -10334
H2BC12 -11325 -5127
PIWIL4 -8830 -6551
NUP188 -11151 -5029
H2AC6 -9780 -5570

Click HERE to show all gene set members

All member genes
KO drug
AAAS -4744.0 12385.0
AGO1 -7681.0 -6719.0
AGO2 -10824.0 -10899.0
AGO3 -9916.0 -8382.0
AGO4 8566.0 -7725.0
ANG -8308.0 6399.0
ASZ1 -3091.0 2588.0
BCDIN3D 6633.0 -609.0
DDX4 -147.0 1685.0
DGCR8 5463.0 11973.0
DICER1 9558.0 -10089.0
DROSHA 8522.0 -840.0
ELAC2 -9745.0 -1209.0
FKBP6 -3045.0 4019.0
H2AB1 1660.0 3002.0
H2AC18 -423.0 1717.0
H2AC20 4883.0 12475.0
H2AC6 -9780.0 -5570.0
H2AC7 -4712.0 3732.0
H2AJ 10209.0 12881.0
H2AZ1 -5624.0 10622.0
H2AZ2 11794.0 9855.0
H2BC11 -9400.0 4223.0
H2BC12 -11325.0 -5127.0
H2BC13 -3431.0 4126.0
H2BC15 -10438.0 -2637.0
H2BC17 -4337.0 6295.0
H2BC21 -9686.0 5246.0
H2BC4 -8905.0 4090.0
H2BC5 -10114.0 11266.0
H2BC9 4874.0 7802.0
H2BU1 7724.0 6707.0
H3-3A 10967.0 12329.0
H3C1 -1179.0 2773.0
H3C15 2532.5 7678.5
HENMT1 12193.0 9214.0
HSP90AA1 11397.0 -7534.0
IPO8 9161.0 -9736.0
MAEL 1932.0 -607.0
MYBL1 8942.0 5892.0
NDC1 -5800.0 -9199.0
NUP107 10317.0 11210.0
NUP133 6251.0 -8590.0
NUP153 -8447.0 -10433.0
NUP155 1534.0 -10720.0
NUP160 -10172.0 -9854.0
NUP188 -11151.0 -5029.0
NUP205 12369.0 -7848.0
NUP210 12856.0 -5260.0
NUP214 -6331.0 -6303.0
NUP35 -10251.0 8114.0
NUP37 3092.0 10117.0
NUP42 8137.0 9137.0
NUP43 -7490.0 9638.0
NUP50 -10234.0 -3947.0
NUP54 -10563.0 -8348.0
NUP58 -7370.0 -10308.0
NUP62 -5900.0 -6034.0
NUP85 7849.0 10502.0
NUP88 -10968.0 2131.0
NUP93 -6918.0 -6255.0
NUP98 -10847.0 -10135.0
PIWIL2 -8415.0 4782.0
PIWIL4 -8830.0 -6551.0
PLD6 -11240.0 -2847.0
POLR2A -11346.0 -10737.0
POLR2B -9710.0 -9575.0
POLR2C -9451.0 -4938.0
POLR2D -9238.0 4530.0
POLR2E -4690.0 -3689.0
POLR2F -8900.0 12621.0
POLR2G -5631.0 9765.0
POLR2H 7259.0 12667.0
POLR2I -5731.0 12659.0
POLR2J -6932.0 12928.0
POLR2K 8115.0 12316.0
POLR2L 12166.0 11532.0
POM121 -8878.0 -9749.0
POM121C -9406.0 -9089.0
PRKRA -11124.0 -6874.0
RAE1 -7356.0 -5016.0
RAN -5185.0 5548.0
RANBP2 -5941.0 -10334.0
SEC13 -9702.0 -8646.0
SEH1L -9333.0 -5653.0
TARBP2 -646.0 10233.0
TDRD6 1935.0 2808.0
TDRKH 12059.0 -9074.0
TNRC6A 2904.0 -5402.0
TNRC6B -10673.0 -8745.0
TNRC6C -5035.0 -5659.0
TPR 8761.0 -5834.0
TSN -10134.0 -4754.0
TSNAX 6262.0 -4484.0
XPO5 -11181.0 -7902.0





Nucleotide biosynthesis

Nucleotide biosynthesis
metric value
setSize 12
pMANOVA 0.00367
p.adjustMANOVA 0.0042
s.dist 0.581
s.KO -0.482
s.drug -0.324
p.KO 0.00383
p.drug 0.0517




Top 20 genes
Gene KO drug
GART -10887 -9545
PPAT -10102 -9936
IMPDH2 -9060 -9748
CAD -7984 -10810
PAICS -8896 -7785
IMPDH1 -8676 -5498
GMPS -4389 -7492
UMPS -2365 -3118

Click HERE to show all gene set members

All member genes
KO drug
ADSL -7101 5099
ATIC -10939 1689
CAD -7984 -10810
DHODH 7360 10538
GART -10887 -9545
GMPS -4389 -7492
IMPDH1 -8676 -5498
IMPDH2 -9060 -9748
PAICS -8896 -7785
PFAS 10370 10384
PPAT -10102 -9936
UMPS -2365 -3118





Oxidative Stress Induced Senescence

Oxidative Stress Induced Senescence
metric value
setSize 82
pMANOVA 0.0285
p.adjustMANOVA 0.0285
s.dist 0.172
s.KO -0.17
s.drug -0.0223
p.KO 0.00768
p.drug 0.726




Top 20 genes
Gene KO drug
CDK6 -10019 -10704
MAPK1 -9173 -10906
TNRC6B -10673 -8745
MAP2K4 -10073 -9026
MAPK3 -9742 -9271
MAPKAPK3 -9412 -9424
AGO3 -9916 -8382
MINK1 -9952 -8148
MAP2K7 -9331 -8434
PHC3 -7418 -9924
MAPK14 -9586 -7538
RNF2 -7038 -9730
BMI1 -6365 -9563
H2BC12 -11325 -5127
MAP3K5 -6530 -8473
H2AC6 -9780 -5570
AGO1 -7681 -6719
RBBP7 -7044 -6256
CDKN2C -10414 -3360
CBX6 -5993 -5822

Click HERE to show all gene set members

All member genes
KO drug
AGO1 -7681.0 -6719.0
AGO3 -9916.0 -8382.0
AGO4 8566.0 -7725.0
BMI1 -6365.0 -9563.0
CBX2 8151.0 -5128.0
CBX4 5239.0 -5196.0
CBX6 -5993.0 -5822.0
CBX8 8308.0 10487.0
CDK4 8549.0 5365.0
CDK6 -10019.0 -10704.0
CDKN2C -10414.0 -3360.0
CDKN2D -9132.0 -3424.0
E2F1 12280.0 12326.0
E2F2 11932.0 10469.0
E2F3 -1962.0 -2490.0
EED -8207.0 -1581.0
EZH2 11841.0 12709.0
FOS -10951.0 11741.0
H2AB1 1660.0 3002.0
H2AC18 -423.0 1717.0
H2AC20 4883.0 12475.0
H2AC6 -9780.0 -5570.0
H2AC7 -4712.0 3732.0
H2AJ 10209.0 12881.0
H2AZ1 -5624.0 10622.0
H2AZ2 11794.0 9855.0
H2BC11 -9400.0 4223.0
H2BC12 -11325.0 -5127.0
H2BC13 -3431.0 4126.0
H2BC15 -10438.0 -2637.0
H2BC17 -4337.0 6295.0
H2BC21 -9686.0 5246.0
H2BC4 -8905.0 4090.0
H2BC5 -10114.0 11266.0
H2BC9 4874.0 7802.0
H2BU1 7724.0 6707.0
H3-3A 10967.0 12329.0
H3C1 -1179.0 2773.0
H3C15 2532.5 7678.5
JUN 12224.0 6311.0
KDM6B -2868.0 -8061.0
MAP2K3 -8485.0 711.0
MAP2K4 -10073.0 -9026.0
MAP2K6 9842.0 8872.0
MAP2K7 -9331.0 -8434.0
MAP3K5 -6530.0 -8473.0
MAP4K4 -3184.0 -8766.0
MAPK1 -9173.0 -10906.0
MAPK10 10395.0 5960.0
MAPK11 10678.0 4248.0
MAPK14 -9586.0 -7538.0
MAPK3 -9742.0 -9271.0
MAPK8 -3223.0 -5847.0
MAPK9 -1848.0 -6014.0
MAPKAPK2 -3317.0 -7911.0
MAPKAPK3 -9412.0 -9424.0
MAPKAPK5 -8152.0 -3964.0
MDM2 -3386.0 -5606.0
MDM4 3213.0 10020.0
MINK1 -9952.0 -8148.0
MOV10 6666.0 10563.0
PHC1 8769.0 4837.0
PHC2 11301.0 -9451.0
PHC3 -7418.0 -9924.0
RBBP4 -5569.0 -4482.0
RBBP7 -7044.0 -6256.0
RING1 -3031.0 11489.0
RNF2 -7038.0 -9730.0
RPS27A 5357.0 6464.0
SCMH1 7811.0 6193.0
SUZ12 -10605.0 9924.0
TFDP1 9813.0 -4284.0
TFDP2 12211.0 902.0
TNIK 12604.0 -10048.0
TNRC6A 2904.0 -5402.0
TNRC6B -10673.0 -8745.0
TNRC6C -5035.0 -5659.0
TP53 -3433.0 10144.0
TXN -7456.0 12957.0
UBA52 -6807.0 11639.0
UBB -5602.0 12024.0
UBC -10397.0 7017.0





Mitochondrial biogenesis

Mitochondrial biogenesis
metric value
setSize 91
pMANOVA 0.000645
p.adjustMANOVA 0.000815
s.dist 0.239
s.KO -0.223
s.drug -0.0841
p.KO 0.000229
p.drug 0.165




Top 20 genes
Gene KO drug
CREBBP -10387 -10534
GLUD1 -9514 -10318
PPARA -8366 -11101
SOD2 -11234 -8262
PRKAB2 -7701 -10925
CRTC3 -11300 -7391
ATF2 -8942 -9289
CARM1 -11211 -7070
IDH2 -11009 -7176
TFB2M -8527 -9028
ATP5F1B -8379 -9015
GABPA -8877 -8320
NCOA2 -6710 -10904
PPARGC1B -11191 -6465
MAPK14 -9586 -7538
TBL1X -8568 -8247
SAMM50 -10241 -5933
RXRA -9975 -6008
TGS1 -7713 -7446
NRF1 -9525 -5711

Click HERE to show all gene set members

All member genes
KO drug
ACSS2 -11053 7142
ALAS1 4171 -10735
APOO -6201 11850
APOOL -418 -10518
ATF2 -8942 -9289
ATP5F1A 7998 -9624
ATP5F1B -8379 -9015
ATP5F1C -287 12518
ATP5F1D -1232 12979
ATP5F1E -1539 10947
ATP5MC1 10755 12985
ATP5MC2 -3774 12406
ATP5MC3 2759 11175
ATP5ME -5746 13136
ATP5MF -8135 13076
ATP5MG -6440 13061
ATP5PB 6563 -5803
ATP5PD -3802 13152
ATP5PF -6437 12713
ATP5PO -8733 12858
CALM1 11329 -6948
CAMK4 7340 -6703
CARM1 -11211 -7070
CHCHD3 10648 -7217
CHCHD6 2521 520
CHD9 6368 -9728
CREB1 -4739 -8655
CREBBP -10387 -10534
CRTC1 -6916 -2898
CRTC2 -7623 1945
CRTC3 -11300 -7391
CYCS -2044 10884
DMAC2L 10867 2617
DNAJC11 7371 11021
ESRRA -11153 10724
GABPA -8877 -8320
GABPB1 -1712 -4472
GLUD1 -9514 -10318
GLUD2 -5197 -4510
HCFC1 7731 -9516
HDAC3 10500 -7476
HELZ2 6737 -11221
HSPA9 -6955 6549
IDH2 -11009 -7176
IMMT 9914 -9786
MAPK11 10678 4248
MAPK12 -5292 10444
MAPK14 -9586 -7538
MED1 4565 -10954
MEF2C -8056 -4261
MEF2D -282 -10543
MICOS10 10505 12560
MICOS13 -6382 12670
MT-ATP6 8420 13018
MT-ATP8 9404 12604
MTERF1 -5272 6828
MTX1 10553 11989
MTX2 -10384 10819
NCOA1 4263 -8396
NCOA2 -6710 -10904
NCOA6 -1205 -9301
NCOR1 -8203 -6322
NR1D1 -10996 4719
NRF1 -9525 -5711
PERM1 6967 10353
POLG2 7584 4971
POLRMT -9425 -2950
PPARA -8366 -11101
PPARGC1A 10444 -5499
PPARGC1B -11191 -6465
PPRC1 -10837 -4822
PRKAA2 -3279 -8609
PRKAB1 -5203 -6241
PRKAB2 -7701 -10925
PRKAG1 -6785 -7254
PRKAG2 9883 -5624
RXRA -9975 -6008
SAMM50 -10241 -5933
SIRT3 -2652 10081
SIRT4 -4587 9390
SIRT5 -1620 6695
SMARCD3 11978 11422
SOD2 -11234 -8262
SSBP1 12278 12643
TBL1X -8568 -8247
TBL1XR1 -3958 -9641
TFAM -2311 -6575
TFB1M -11120 4823
TFB2M -8527 -9028
TGS1 -7713 -7446
TMEM11 -10746 7881





Phospholipid metabolism

Phospholipid metabolism
metric value
setSize 186
pMANOVA 3.53e-12
p.adjustMANOVA 1.41e-11
s.dist 0.319
s.KO -0.147
s.drug -0.283
p.KO 0.000525
p.drug 2.57e-11




Top 20 genes
Gene KO drug
PLEKHA2 -11451 -10431
MTMR12 -10618 -11138
CSNK2A1 -10604 -10586
CPNE3 -9909 -10952
PITPNM1 -9832 -10911
PIKFYVE -10388 -10306
PLA2G4A -11353 -9250
CSNK2A2 -9949 -10332
DDHD2 -11261 -9027
AGPAT5 -11194 -8876
AGPAT3 -10865 -9124
RAB14 -9162 -10367
PIK3CB -9217 -10250
PITPNB -10732 -8304
PNPLA8 -10281 -8614
SBF2 -7579 -11053
DDHD1 -8454 -9590
PNPLA3 -9617 -8407
MTMR3 -7836 -10186
MBOAT2 -9788 -8124

Click HERE to show all gene set members

All member genes
KO drug
ABHD3 3550 11200
ABHD4 -4078 -7842
ACHE 9948 -44
ACP6 12363 -5186
AGK 12316 10534
AGPAT1 12340 -8581
AGPAT2 -7585 10548
AGPAT3 -10865 -9124
AGPAT4 -11056 9424
AGPAT5 -11194 -8876
ARF1 -9163 -5561
ARF3 3251 -6648
BCHE 7338 10241
CDIPT -8739 -6855
CDS1 -5536 -2686
CDS2 12495 -9650
CEPT1 -2571 -8803
CHAT 6776 -3180
CHKA -9195 12581
CHKB 11206 12778
CHPT1 -2663 -5035
CPNE1 -7557 11964
CPNE3 -9909 -10952
CPNE7 217 12014
CRLS1 -9065 -3075
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
CSNK2B -9249 12011
DDHD1 -8454 -9590
DDHD2 -11261 -9027
DGAT1 -3372 10410
DGAT2 -10973 9278
ENPP6 -380 4251
ETNK1 -6875 -4750
ETNK2 4136 -8591
FIG4 10135 -5525
GDE1 -5489 -5600
GDPD1 6538 -5821
GDPD3 -8814 10429
GDPD5 -5058 -4242
GNPAT -3027 5570
GPAM 9347 -8178
GPAT2 -3610 6349
GPAT3 -3147 -8656
GPAT4 -9453 -6583
GPCPD1 -11362 12472
GPD1 1 6256
GPD1L -393 5259
GPD2 8694 -9821
HADHA 10596 -8030
HADHB -424 -8570
INPP4A -6949 -8897
INPP4B 7799 1151
INPP5D 12494 -6335
INPP5E -9231 9571
INPP5F -6267 -8385
INPP5J 2774 6306
INPP5K -2145 5151
INPPL1 -7710 -4327
LCLAT1 -5766 -9874
LIPH 3458 5131
LPCAT1 -3028 -5868
LPCAT2 -5840 -6904
LPCAT3 12306 8926
LPCAT4 -10814 11636
LPGAT1 9789 -9221
LPIN1 -10795 -5721
LPIN2 7561 -11087
LPIN3 3240 9122
MBOAT1 -7369 -4354
MBOAT2 -9788 -8124
MBOAT7 4107 -7700
MFSD2A -11012 3357
MGLL 12726 -10604
MIGA1 -4880 -10227
MIGA2 -8827 11729
MTM1 -4584 -7808
MTMR1 10448 -7007
MTMR10 9939 -6395
MTMR12 -10618 -11138
MTMR14 -5165 7975
MTMR2 -6094 -9336
MTMR3 -7836 -10186
MTMR4 -4934 -8877
MTMR6 -5385 -8925
MTMR7 -5015 4886
MTMR9 -9350 -8112
OCRL -3909 -8515
OSBPL10 12422 -10923
OSBPL5 -8362 -5759
OSBPL8 -6521 -10242
PCTP 12215 -8293
PCYT1A 1479 -5733
PCYT2 -7783 12466
PEMT -5793 8198
PGS1 -5196 -5724
PHOSPHO1 -4356 8844
PI4K2A -7282 -6755
PI4K2B -4371 -7468
PI4KA 10503 -5896
PI4KB 5739 -10289
PIK3C2A -5604 -9519
PIK3C2B 7510 -6252
PIK3C3 -8170 -7865
PIK3CA -5426 -9599
PIK3CB -9217 -10250
PIK3CD 8125 -9524
PIK3CG 8376 -5110
PIK3R1 10169 -9568
PIK3R2 -6506 -5848
PIK3R3 9654 -3457
PIK3R4 9611 -9422
PIK3R5 -1767 107
PIK3R6 12716 -2472
PIKFYVE -10388 -10306
PIP4K2A 8236 -8090
PIP4K2B -3399 1126
PIP4K2C 8425 -9498
PIP5K1A 7428 -9178
PIP5K1B 6218 -6738
PIP5K1C -7525 -1015
PISD -10547 4750
PITPNB -10732 -8304
PITPNM1 -9832 -10911
PITPNM2 -6158 -4679
PITPNM3 462 2559
PLA1A 1097 1226
PLA2G10 301 4728
PLA2G12A 8760 -7403
PLA2G15 -6553 -5088
PLA2G4A -11353 -9250
PLA2G4B 6200 13064
PLA2G4C 9981 -5934
PLA2G4D 1634 4664
PLA2G5 -11263 7586
PLA2G6 -8707 12727
PLA2R1 12453 -6182
PLAAT1 2388 -4908
PLAAT3 12878 12588
PLAAT4 10410 12384
PLB1 -664 4620
PLBD1 12507 39
PLD1 12766 -9763
PLD2 -7320 -7936
PLD3 9531 -3623
PLD4 2571 7880
PLD6 -11240 -2847
PLEKHA1 -5829 -10175
PLEKHA2 -11451 -10431
PLEKHA3 -9653 -6310
PLEKHA4 -3065 10468
PLEKHA5 -8831 -7991
PLEKHA6 10937 7485
PLEKHA8 5033 -9481
PNPLA2 -6634 -2945
PNPLA3 -9617 -8407
PNPLA6 -9579 -4893
PNPLA7 4383 9842
PNPLA8 -10281 -8614
PTDSS1 -4830 -8543
PTDSS2 10798 5487
PTEN -6933 -8533
PTPMT1 -6485 12300
PTPN13 12622 -7833
RAB14 -9162 -10367
RAB4A 6470 -4166
RAB5A -7843 -8483
RUFY1 -2346 11546
SACM1L -7553 -7666
SBF1 -7013 -7405
SBF2 -7579 -11053
SELENOI -6323 -9929
SLC44A1 3030 -8195
SLC44A2 11423 -6429
SLC44A3 9846 -2785
SLC44A5 8809 -7261
STARD10 -11280 10122
STARD7 5228 -9022
SYNJ1 -6939 -6072
SYNJ2 7547 -5487
TAZ 8218 12600
TMEM86B -4684 10657
TNFAIP8 -8871 -5353
TNFAIP8L1 -9972 -6812
TNFAIP8L3 6293 3816
VAC14 -9751 -7774





Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)
metric value
setSize 106
pMANOVA 5.99e-05
p.adjustMANOVA 0.000103
s.dist 0.255
s.KO -0.234
s.drug -0.102
p.KO 3.07e-05
p.drug 0.0699




Top 20 genes
Gene KO drug
ITPR1 -11523 -11275
PSME4 -10581 -10843
NFKB1 -10600 -10807
RELA -10894 -10457
PSMD1 -9192 -10441
NCK1 -9577 -9993
NFATC1 -9218 -9228
NFATC3 -8816 -9311
ITPR2 -7642 -10382
PSMD5 -9642 -8039
PSMA7 -10164 -7607
ORAI1 -8021 -9480
SOS1 -7259 -9921
NFATC2 -11381 -6299
REL -6969 -10200
PSMD2 -6801 -10378
GRB2 -6137 -10524
PPP3CB -8974 -7138
PSMD8 -9103 -6526
BCL10 -8460 -6848

Click HERE to show all gene set members

All member genes
KO drug
AHCYL1 5721 -10813
BCL10 -8460 -6848
BLK -618 -3097
BLNK 5998 -3402
BTK -1000 2113
BTRC -4856 -8431
CALM1 11329 -6948
CARD11 -3145 1745
CD22 3605 5134
CD79A -5516 1600
CD79B 5399 1704
CHUK -2503 -6194
CUL1 11196 -4981
FBXW11 -5120 -11073
FKBP1A 11955 9396
FYN -11380 -3570
GRB2 -6137 -10524
HRAS -8054 12320
IKBKB 11568 8115
IKBKG 8074 8626
ITPR1 -11523 -11275
ITPR2 -7642 -10382
ITPR3 969 -10878
KRAS 12719 -8619
LYN 11194 -6028
MALT1 -3704 -5480
MAP3K7 -4055 -7297
NCK1 -9577 -9993
NFATC1 -9218 -9228
NFATC2 -11381 -6299
NFATC3 -8816 -9311
NFKB1 -10600 -10807
NFKBIA -8197 739
NFKBIB -8585 9505
NFKBIE -3277 -6245
NRAS -3309 -9724
ORAI1 -8021 -9480
ORAI2 10030 -10559
PIK3AP1 9731 -5428
PIK3CD 8125 -9524
PIK3R1 10169 -9568
PLCG2 -6464 -3252
PPIA 3756 13113
PPP3CA 10840 -10652
PPP3CB -8974 -7138
PPP3R1 -5334 -9996
PRKCB 12683 -6223
PSMA1 -9646 10578
PSMA2 -4002 -4430
PSMA3 -5668 12561
PSMA4 -9907 11447
PSMA5 5538 826
PSMA6 -3328 8997
PSMA7 -10164 -7607
PSMB1 -6139 12480
PSMB10 9537 11663
PSMB2 -3364 8976
PSMB3 7905 13078
PSMB4 -1370 12998
PSMB5 -6937 -2970
PSMB6 -6537 10901
PSMB7 -8656 12462
PSMB8 -9783 11153
PSMB9 -9810 10733
PSMC1 -3547 -3814
PSMC2 -9185 11068
PSMC3 -1273 12327
PSMC4 -7156 12714
PSMC5 7024 12041
PSMC6 -7069 697
PSMD1 -9192 -10441
PSMD10 -6869 1286
PSMD11 7720 -8518
PSMD12 813 8775
PSMD13 -5300 12140
PSMD14 -10615 8461
PSMD2 -6801 -10378
PSMD3 -8058 -4798
PSMD4 743 11756
PSMD5 -9642 -8039
PSMD6 -7577 12228
PSMD7 -6198 -6043
PSMD8 -9103 -6526
PSMD9 -7638 -3346
PSME1 -8654 11878
PSME2 -4231 12869
PSME3 11811 -7813
PSME4 -10581 -10843
PSMF1 -7549 -4369
PTPN6 3206 5586
RASGRP1 4603 -4416
RASGRP3 -7415 5200
REL -6969 -10200
RELA -10894 -10457
RPS27A 5357 6464
SEM1 -9978 13108
SH3KBP1 6290 -8226
SKP1 179 -9573
SOS1 -7259 -9921
STIM1 12341 -6990
SYK 11473 -3487
TRPC1 5911 -6807
UBA52 -6807 11639
UBB -5602 12024
UBC -10397 7017
VAV1 -4339 5985





Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
metric value
setSize 52
pMANOVA 0.00175
p.adjustMANOVA 0.0021
s.dist 0.298
s.KO -0.235
s.drug -0.183
p.KO 0.00334
p.drug 0.0225




Top 20 genes
Gene KO drug
ME2 -10992 -10086
SDHA -10480 -9986
SLC16A1 -10562 -9859
CS -9273 -10545
MDH2 -10661 -8768
DLST -8194 -10831
IDH2 -11009 -7176
DLD -9253 -8294
PDP2 -8514 -8538
DLAT -8123 -7745
RXRA -9975 -6008
PDK3 -6613 -8798
SUCLG2 -6338 -8917
PDPR -6645 -8103
PDK1 -5018 -9225
PDHX -9039 -4928
LDHA -4687 -9205
OGDH -5384 -7828
IDH3A -8898 -3067
SDHD -9641 -2716

Click HERE to show all gene set members

All member genes
KO drug
ACO2 -5040 -2386
ADHFE1 5031 7843
BSG -5149 12544
CS -9273 -10545
D2HGDH 8528 8058
DLAT -8123 -7745
DLD -9253 -8294
DLST -8194 -10831
FAHD1 -6287 7691
FH -396 11082
GLO1 -8377 4629
GSTZ1 10777 8707
HAGH 10014 11571
IDH2 -11009 -7176
IDH3A -8898 -3067
IDH3B -4300 -4551
IDH3G 117 9128
L2HGDH 7092 -9403
LDHA -4687 -9205
LDHAL6A -1233 5274
LDHAL6B 5276 -3235
LDHB 3274 2139
MDH2 -10661 -8768
ME1 6821 -7488
ME2 -10992 -10086
ME3 -8506 7768
MPC1 -6561 11380
MPC2 -5160 7935
NNT 4483 -10790
OGDH -5384 -7828
PDHA1 -10664 11842
PDHB -3368 12152
PDHX -9039 -4928
PDK1 -5018 -9225
PDK2 11377 2039
PDK3 -6613 -8798
PDK4 10934 -3798
PDP1 11745 -9417
PDP2 -8514 -8538
PDPR -6645 -8103
PPARD -11069 6617
RXRA -9975 -6008
SDHA -10480 -9986
SDHB -299 5982
SDHC 9345 -5559
SDHD -9641 -2716
SLC16A1 -10562 -9859
SLC16A3 11791 -6452
SUCLA2 3325 -7651
SUCLG1 1114 10597
SUCLG2 -6338 -8917
VDAC1 10321 -414





Nervous system development

Nervous system development
metric value
setSize 522
pMANOVA 8.27e-12
p.adjustMANOVA 2.83e-11
s.dist 0.19
s.KO -0.119
s.drug -0.149
p.KO 3.47e-06
p.drug 5.53e-09




Top 20 genes
Gene KO drug
MMP9 -11544 -11274
NRP2 -11503 -11235
ITGA5 -11427 -11242
SEMA5A -11537 -10912
NUMB -11352 -10801
MYO10 -11283 -10773
HSPA8 -10759 -11259
SREBF2 -10833 -10659
PSME4 -10581 -10843
GSPT1 -11018 -10260
CSNK2A1 -10604 -10586
PAK1 -11464 -9735
YES1 -10903 -10141
EPHB4 -11068 -9972
DLG4 -11488 -9265
MYH9 -10470 -10143
ARPC2 -10726 -9893
HMGCR -9941 -10570
SLIT2 -11365 -9218
TLN1 -10315 -10054

Click HERE to show all gene set members

All member genes
KO drug
ABL1 11663 -8885
ABL2 -6876 -10017
ABLIM1 12140 -5473
ABLIM2 8499 -1532
ABLIM3 5148 -9372
ACTB 10250 11107
ACTG1 10519 -8874
ACTR2 1714 -9008
ACTR3 -7983 -9109
ADAM10 11732 -10321
ADGRG6 12571 -7103
ADGRV1 11199 2246
AGAP2 12302 -4149
AGRN 12518 -11205
AKAP5 6930 2937
ALCAM 8663 -10885
ANK1 5860 -2296
ANK2 9200 -6191
ANK3 6882 -11122
AP2A1 -6997 -8134
AP2A2 -6539 -5045
AP2B1 12427 -10984
AP2M1 10151 -6181
AP2S1 8881 6008
APH1A 3143 -9778
APH1B 12138 -9680
ARHGAP35 10763 -10603
ARHGAP39 2704 -3971
ARHGEF11 9309 -5070
ARHGEF12 -4861 -10733
ARHGEF28 9466 -7473
ARHGEF7 4838 -2908
ARPC1A -10481 3397
ARPC1B -11473 -6676
ARPC2 -10726 -9893
ARPC3 -8304 12552
ARPC4 -4723 7412
ARPC5 6471 -8526
ARTN 3982 5769
CACNA1C 11357 -4385
CACNA1D 12251 7919
CACNA1G 12204 2461
CACNA1H 11853 -9013
CACNA1I -5455 -467
CACNA1S 12889 12848
CACNB1 8009 12232
CACNB2 -2901 9935
CACNB3 -10750 131
CACNB4 -8708 2250
CAP1 -4846 -10201
CAP2 -1498 -6337
CASC3 3621 -10268
CD24 -2000 -10169
CD72 -627 3306
CDC42 -7820 -8450
CDK5 11365 11879
CDK5R1 -8980 -5890
CFL1 121 10816
CLASP1 -6791 -4673
CLASP2 -2745 -8780
CLTA -11070 -5228
CLTB -4297 11260
CLTC 7619 -11201
CLTCL1 -6977 -6100
CNTN1 10624 -6687
CNTN2 631 4882
CNTNAP1 7446 -5304
COL4A1 12144 -2998
COL4A2 12287 -5744
COL4A3 -6350 1696
COL4A5 12376 8368
COL6A1 11520 -9499
COL6A2 12038 -8896
COL6A3 -7285 -8785
COL6A5 12043 -4664
COL6A6 3485 3246
COL9A2 6591 12969
COL9A3 -10080 11319
CREB1 -4739 -8655
CRMP1 -9467 8204
CSNK2A1 -10604 -10586
CSNK2A2 -9949 -10332
CSNK2B -9249 12011
CUL2 -2032 -10093
CXCR4 -6274 -7315
CYP51A1 -11252 -9071
DAB1 9510 2041
DAG1 6148 -8573
DCC 2949 -9359
DLG1 -9408 -9725
DLG3 9011 -7397
DLG4 -11488 -9265
DNM1 11730 13133
DNM2 -8486 -5605
DNM3 7268 -4103
DOCK1 10264 -10777
DOK1 1398 -8254
DOK4 -10395 586
DOK5 -10107 4942
DOK6 5775 -5585
DPYSL2 -8515 -6617
DPYSL3 8962 -9979
DPYSL4 2668 -540
DPYSL5 12108 943
DRP2 -8595 8869
DSCAML1 -6067 -4372
EFNA1 10320 -3995
EFNA2 4840 6472
EFNA3 -8124 349
EFNA4 -5971 1975
EFNA5 12768 -9515
EFNB1 10712 -7077
EFNB2 -6633 -10416
EFNB3 6767 -10423
EGFR 2126 -11093
EGR2 954 -3948
EIF4A3 -628 -6343
EIF4G1 9159 -10287
ELOB -9703 13020
ELOC -7394 12764
ENAH -5418 -8470
EPHA1 5746 4236
EPHA10 4822 -1507
EPHA2 12770 -6176
EPHA4 -11465 -8650
EPHA5 -3260 -3285
EPHA6 9254 -1582
EPHA7 678 4787
EPHA8 -3259 -859
EPHB1 11576 -10174
EPHB2 -10975 -6661
EPHB3 5660 3815
EPHB4 -11068 -9972
EPHB6 -11501 8239
ERBB2 3816 -5849
ETF1 -5515 -9496
EVL 9744 10446
EZR -11288 -7422
FARP2 7041 -460
FAU -8610 13102
FES -8923 54
FGFR1 -10613 -7876
FLRT3 -7271 -9898
FRS2 -6455 -9318
FYN -11380 -3570
GAB1 -6660 -8223
GAB2 -8602 -8733
GAP43 12703 -6230
GDNF 12813 -11239
GFRA1 -4667 3017
GFRA2 12100 -6635
GIT1 1429 -3900
GPC1 1951 -7922
GRB10 -7242 -10690
GRB2 -6137 -10524
GRB7 -7561 965
GRIN1 1772 1917
GRIN2B -86 -4571
GSK3B 7016 -10755
GSPT1 -11018 -10260
GSPT2 -5509 -6727
HDAC2 -9786 -6704
HMGCR -9941 -10570
HOXA2 8898 12312
HRAS -8054 12320
HSP90AA1 11397 -7534
HSP90AB1 -9168 -9114
HSPA8 -10759 -11259
IRS2 -1938 -10094
ISL1 -4207 3822
ITGA1 12258 -10552
ITGA10 -11438 1671
ITGA2 8062 -11213
ITGA2B -5878 9166
ITGA5 -11427 -11242
ITGA9 12791 -9989
ITGAV 144 -11011
ITGB1 -3655 -11215
ITGB3 12688 -11286
ITSN1 -10095 -8537
KALRN -7355 -9904
KCNQ2 -5921 12096
KCNQ3 9606 -7783
KIF4A 7632 -878
KRAS 12719 -8619
L1CAM 12673 -11189
LAMA1 12802 -10091
LAMA2 -8729 -4165
LAMB1 -9087 -10329
LAMC1 12854 -11227
LDB1 4147 748
LHX2 10308 -302
LHX4 11564 -5603
LHX9 9237 -4741
LIMK1 8691 8272
LIMK2 -6025 1750
LYN 11194 -6028
LYPLA2 5663 5825
MAGOH -5607 12947
MAGOHB -7769 12200
MAP2K1 10407 -10989
MAP2K2 -8526 6661
MAPK1 -9173 -10906
MAPK11 10678 4248
MAPK12 -5292 10444
MAPK13 -475 10415
MAPK14 -9586 -7538
MAPK3 -9742 -9271
MAPK7 -7980 -4568
MAPK8 -3223 -5847
MBP -2678 984
MET 10796 -11047
MMP2 12429 -8269
MMP9 -11544 -11274
MSI1 9573 10261
MSN 10752 -10996
MYH10 10412 -9280
MYH11 -3795 3493
MYH14 -7452 -2004
MYH9 -10470 -10143
MYL12A 8344 -4820
MYL12B -8083 12443
MYL6 -6131 6237
MYL9 7628 11186
MYO10 -11283 -10773
MYO9B -10955 -6713
NAB1 -7796 -8345
NAB2 -11022 8542
NCAM1 -5432 8870
NCAN 3533 -1773
NCBP1 -7784 -5234
NCBP2 -6378 -6281
NCK1 -9577 -9993
NCK2 -10111 -6626
NCSTN 11563 -4277
NELL2 12693 -7880
NEO1 12310 -9227
NFASC -4408 5984
NGEF 7391 -10445
NRAS -3309 -9724
NRCAM 9844 -9135
NRP1 12492 -10673
NRP2 -11503 -11235
NRTN -6424 10119
NTN1 12777 -9806
NTN4 -8804 -7703
NUMB -11352 -10801
PABPC1 -7033 -10406
PAK1 -11464 -9735
PAK2 -6371 -10285
PAK3 9899 -7417
PAK4 -8948 -6862
PAK5 10389 -4026
PAK6 1878 388
PDLIM7 -6297 11933
PFN1 -1501 -842
PFN2 10490 -10371
PIK3CA -5426 -9599
PIK3CB -9217 -10250
PIK3CD 8125 -9524
PIK3R1 10169 -9568
PIK3R2 -6506 -5848
PIK3R3 9654 -3457
PIP5K1C -7525 -1015
PITPNA 7881 -9463
PLCG1 -8518 10852
PLXNA1 12834 -10985
PLXNA2 -1563 -6909
PLXNA3 -7350 1983
PLXNA4 11726 -9845
PLXNB1 -4940 12049
PLXNB3 11348 -6567
PLXNC1 7782 -4730
PLXND1 11557 -4291
PMP22 -958 -9982
POU3F1 3943 6293
POU3F2 11400 -9095
PPP3CB -8974 -7138
PRKACA 8250 9679
PRKACB 8849 -9614
PRKAR2A -5980 -10943
PRKCA 12366 -10396
PRKCQ 10159 -4784
PRNP -8139 -10664
PRX -7283 -8489
PSEN1 -5670 -10549
PSEN2 10087 11419
PSENEN 8070 12798
PSMA1 -9646 10578
PSMA2 -4002 -4430
PSMA3 -5668 12561
PSMA4 -9907 11447
PSMA5 5538 826
PSMA6 -3328 8997
PSMA7 -10164 -7607
PSMB1 -6139 12480
PSMB10 9537 11663
PSMB2 -3364 8976
PSMB3 7905 13078
PSMB4 -1370 12998
PSMB5 -6937 -2970
PSMB6 -6537 10901
PSMB7 -8656 12462
PSMB8 -9783 11153
PSMB9 -9810 10733
PSMC1 -3547 -3814
PSMC2 -9185 11068
PSMC3 -1273 12327
PSMC4 -7156 12714
PSMC5 7024 12041
PSMC6 -7069 697
PSMD1 -9192 -10441
PSMD10 -6869 1286
PSMD11 7720 -8518
PSMD12 813 8775
PSMD13 -5300 12140
PSMD14 -10615 8461
PSMD2 -6801 -10378
PSMD3 -8058 -4798
PSMD4 743 11756
PSMD5 -9642 -8039
PSMD6 -7577 12228
PSMD7 -6198 -6043
PSMD8 -9103 -6526
PSMD9 -7638 -3346
PSME1 -8654 11878
PSME2 -4231 12869
PSME3 11811 -7813
PSME4 -10581 -10843
PSMF1 -7549 -4369
PSPN -6136 -3833
PTK2 -9167 -10148
PTPN11 -6877 -9390
PTPRA 192 -8083
RAC1 -7472 -3724
RANBP9 -7563 -9308
RAP1GAP 10891 786
RASA1 8981 -10567
RBM8A 8447 9246
RBX1 -9316 12919
RDX -7627 -9606
RELN -11002 -7939
RET -87 -1793
RGMA -9460 -1155
RGMB -5729 -10677
RHOA -7410 -9917
RHOB 12575 6440
RHOC -6764 -10429
RND1 -7788 8752
RNPS1 -10981 -5614
ROBO1 -4716 -10678
ROBO2 -6358 1760
ROBO3 -7871 12150
ROCK1 -3805 -11029
ROCK2 12303 -9632
RPL10 -3821 1597
RPL10A -9707 -8212
RPL11 -8529 12382
RPL12 -9329 12992
RPL13 -3469 12598
RPL13A -6854 6955
RPL14 -6386 13137
RPL15 -786 12153
RPL17 -8989 12909
RPL18 -6672 12800
RPL18A -6976 11926
RPL19 3924 12911
RPL21 -6322 5141
RPL22 -5554 9520
RPL22L1 -10448 12221
RPL23 5769 12922
RPL23A 11361 -5257
RPL24 -4591 12995
RPL26 -8797 12658
RPL26L1 -9387 12770
RPL27 6735 11625
RPL27A -7818 13051
RPL28 -5809 12962
RPL29 -4515 12915
RPL3 -6827 -4535
RPL30 -3907 11096
RPL31 -8781 13131
RPL32 -5028 12983
RPL34 -9357 12996
RPL35 -8027 13097
RPL35A -1449 12789
RPL36 -8818 12868
RPL36A -4480 13009
RPL36AL -8216 12702
RPL37 -4624 13134
RPL37A -9347 12675
RPL38 1558 13140
RPL39 -6168 11962
RPL39L -6608 -6269
RPL3L -510 7904
RPL4 11351 12558
RPL41 -4616 -6074
RPL5 4679 12075
RPL6 -6903 12730
RPL7 -3327 -8789
RPL7A -6163 11708
RPL8 -7572 10323
RPL9 -9659 12806
RPLP0 -1504 -7331
RPLP1 9026 12731
RPLP2 -8225 12999
RPS10 -8384 10665
RPS11 -7725 12935
RPS12 -7872 11600
RPS13 -9450 12652
RPS14 -1180 12428
RPS15 -7430 12908
RPS15A -8754 12989
RPS16 -3844 12941
RPS17 -10534 11631
RPS18 -9122 12984
RPS19 -7633 12888
RPS2 -10222 8916
RPS20 -4961 13095
RPS21 -3001 13022
RPS23 6940 11907
RPS24 2369 13034
RPS25 -9371 12690
RPS26 -2615 13114
RPS27 651 11270
RPS27A 5357 6464
RPS27L 7330 12750
RPS28 2716 12485
RPS29 -652 9078
RPS3 -7756 12135
RPS3A -9170 5257
RPS4X -8542 12239
RPS5 -6283 -7965
RPS6 -9225 12405
RPS6KA1 12818 -7761
RPS6KA2 -8378 -9101
RPS6KA3 -8355 -9502
RPS6KA4 209 5353
RPS6KA5 -8869 -7063
RPS6KA6 -2223 3989
RPS7 5142 12976
RPS8 -5812 12745
RPS9 -8815 10189
RPSA 292 11576
RRAS -10711 11191
SCD5 -8562 -8561
SCN11A -1197 7037
SCN1B -7035 -4146
SCN2A 1009 2562
SCN2B -2178 1537
SCN3A -5082 1832
SCN3B -3989 -3340
SCN4B 11633 290
SCN5A 10354 -6646
SCN7A -2071 4709
SCN8A 9310 -1922
SCN9A 6184 6251
SDC2 -6754 -5737
SDCBP -7932 -10803
SEM1 -9978 13108
SEMA3A -8520 -8259
SEMA4A -31 5409
SEMA4D 9903 32
SEMA5A -11537 -10912
SEMA6A 12824 -7654
SEMA6D -5924 -7539
SEMA7A 9143 -11223
SH3GL2 9242 -4988
SH3KBP1 6290 -8226
SHANK3 10993 -7919
SHC1 12549 -9462
SHC3 -9551 -7860
SHTN1 11966 -9257
SIAH1 6081 -3908
SIAH2 -7707 -9583
SLIT1 12338 -6263
SLIT2 -11365 -9218
SLIT3 12621 -9830
SMARCA4 -3679 -7145
SOS1 -7259 -9921
SOS2 9761 -9317
SPTAN1 -1079 -7432
SPTB 8651 7910
SPTBN1 12206 -10986
SPTBN2 10820 -10000
SPTBN4 -6086 -1522
SPTBN5 -472 5718
SRC -11388 -7284
SREBF2 -10833 -10659
SRGAP1 -5850 -7090
SRGAP2 11419 -6780
SRGAP3 10137 -6776
ST8SIA2 -1592 -3655
ST8SIA4 8099 -7867
TEAD1 -5400 -10624
TIAM1 11077 -6419
TLN1 -10315 -10054
TRIO 10149 -6772
TRPC1 5911 -6807
TRPC3 -2298 -2648
TRPC4 -7857 1978
UBA52 -6807 11639
UBB -5602 12024
UBC -10397 7017
UNC5A 12538 -8663
UNC5B -7467 -10080
UNC5C 10995 -3568
UNC5D -7177 -8180
UPF2 6857 -7169
UPF3A -8410 11718
UPF3B -3041 12685
USP33 1911 -8690
UTRN 9433 -10574
VASP -9209 -6573
VAV2 -4256 -7899
VAV3 -7453 2853
VLDLR 9774 -11204
WASL -8668 -8587
WWTR1 10572 -10736
YAP1 -5571 -10960
YES1 -10903 -10141
ZSWIM8 10701 -5986





Metabolism

Metabolism
metric value
setSize 1856
pMANOVA 0.00042
p.adjustMANOVA 0.00056
s.dist 0.057
s.KO -0.0501
s.drug -0.027
p.KO 0.000324
p.drug 0.0524




Top 20 genes
Gene KO drug
ITPR1 -11523 -11275
SEC24D -11430 -11236
ARG2 -11492 -11033
OSBP -11432 -11066
PPP2R5D -11383 -11113
IQGAP1 -11188 -11226
NCOA3 -11270 -11034
B4GALT1 -11375 -10725
HS3ST3B1 -11527 -10530
PLEKHA2 -11451 -10431
XYLT1 -11081 -10705
MTMR12 -10618 -11138
ADCY7 -11317 -10422
LRP12 -10595 -11129
SREBF2 -10833 -10659
PSME4 -10581 -10843
CSGALNACT2 -10808 -10564
PPP2CB -11374 -10028
PYGB -11296 -9947
CSNK2A1 -10604 -10586

Click HERE to show all gene set members

All member genes
KO drug
AAAS -4744.0 12385
AACS 1343.0 -6189
AADAT 10672.0 7274
AANAT 12010.0 -5836
AASDHPPT -7781.0 -4901
AASS -2035.0 -7338
ABCA1 -7160.0 -10627
ABCB1 9940.0 -4711
ABCB11 2944.0 -1218
ABCB4 12709.0 -8356
ABCB7 8692.0 -10036
ABCC1 -10345.0 -8280
ABCC2 4733.0 6426
ABCC3 12499.0 10837
ABCC5 9428.0 10051
ABCC8 7897.0 5217
ABCD1 9287.0 8795
ABCD4 10878.0 12148
ABCG2 2336.0 -3473
ABHD10 -11231.0 -4814
ABHD14B 11952.0 9001
ABHD3 3550.0 11200
ABHD4 -4078.0 -7842
ABHD5 1064.0 -6657
ABO -4213.0 5177
ACAA1 -4953.0 11750
ACAA2 10396.0 -7152
ACACA 11587.0 -9231
ACACB 10941.0 6062
ACAD10 -4682.0 5611
ACAD11 11686.0 11919
ACAD8 11347.0 11473
ACAD9 12457.0 11377
ACADL 8538.0 8414
ACADM 11816.0 -7756
ACADS 6860.0 2972
ACADSB 8386.0 4523
ACADVL 2389.0 12145
ACAN -11431.0 -5454
ACAT1 -10638.0 -4238
ACAT2 -10960.0 7414
ACBD4 11086.0 8493
ACBD5 -8935.0 -9274
ACBD6 9618.0 7732
ACBD7 7658.0 10413
ACER2 -5135.0 -4867
ACER3 12167.0 -10968
ACHE 9948.0 -44
ACLY -5483.0 -10039
ACO2 -5040.0 -2386
ACOT1 7027.0 8597
ACOT11 12014.0 10401
ACOT13 1622.0 13024
ACOT2 11129.0 10447
ACOT4 -4555.0 260
ACOT7 1170.0 -5089
ACOT8 7723.0 8533
ACOT9 -1195.0 9258
ACOX1 7261.0 -7982
ACOX2 -7996.0 -2272
ACOX3 -6026.0 -7034
ACOXL 7706.0 6794
ACP5 2052.0 4569
ACP6 12363.0 -5186
ACSBG1 6454.0 -166
ACSBG2 2129.0 -1265
ACSF2 11490.0 7592
ACSF3 10362.0 -4143
ACSL1 -10761.0 -9001
ACSL3 -8531.0 -10470
ACSL4 7111.0 -10248
ACSL5 10146.0 3509
ACSL6 3266.0 320
ACSM2A 702.0 5396
ACSM2B 4526.0 6365
ACSM3 -3701.0 1817
ACSS1 9723.0 -5086
ACSS2 -11053.0 7142
ACSS3 12795.0 -3663
ACY1 12101.0 10851
ACY3 -2691.0 7876
ADA -8806.0 -8858
ADAL 11415.0 3650
ADCY1 11934.0 -11008
ADCY2 -11203.0 -2904
ADCY3 -9214.0 -7503
ADCY4 2183.0 -585
ADCY5 11160.0 -6292
ADCY6 12249.0 -10841
ADCY7 -11317.0 -10422
ADCY9 -7412.0 -9235
ADH1B -1410.0 7572
ADH5 -9602.0 5293
ADH6 4290.0 3108
ADHFE1 5031.0 7843
ADI1 -3579.0 9094
ADIPOQ 2279.0 1680
ADIPOR1 981.0 -7013
ADIPOR2 -7270.0 -9992
ADK -8711.0 -5126
ADO 6777.0 -9156
ADPGK 10229.0 10700
ADPRM -10668.0 -2606
ADRA2A 3627.0 -8577
ADSL -7101.0 5099
AFMID -4671.0 7924
AGK 12316.0 10534
AGL 11480.0 -6654
AGMAT 994.0 328
AGPAT1 12340.0 -8581
AGPAT2 -7585.0 10548
AGPAT3 -10865.0 -9124
AGPAT4 -11056.0 9424
AGPAT5 -11194.0 -8876
AGPS 10100.0 -8255
AGRN 12518.0 -11205
AGT -896.0 9184
AHCY 1345.0 629
AHCYL1 5721.0 -10813
AHR 11532.0 -9559
AHRR -3732.0 -4926
AIMP1 -9006.0 1838
AIMP2 1872.0 -2032
AIP -9180.0 11847
AK1 11507.0 11648
AK2 10568.0 11770
AK4 12687.0 -9278
AK5 -11006.0 -4602
AK6 -5056.0 2163
AK7 8247.0 -25
AK8 5270.0 5210
AK9 9223.0 4775
AKAP5 6930.0 2937
AKR1A1 -7653.0 -1413
AKR1B1 12462.0 9788
AKR1B15 -3729.0 2493
AKR1C1 -10089.0 6360
AKR1C3 -11277.0 12190
AKR1D1 4199.0 -863
AKR7A2 -7562.0 -6933
AKR7A3 -2562.0 9849
AKR7L 4465.0 9366
AKT1 -1733.0 -1215
ALAD 11487.0 10437
ALAS1 4171.0 -10735
ALB 5080.0 7354
ALDH18A1 -8886.0 -10473
ALDH1B1 3049.0 -5217
ALDH1L1 10726.0 -4687
ALDH1L2 -9706.0 -2755
ALDH2 8098.0 10715
ALDH3A2 5431.0 -5930
ALDH3B1 4355.0 5738
ALDH4A1 11146.0 -3790
ALDH6A1 -7224.0 -8331
ALDH7A1 10593.0 11100
ALDH9A1 -560.0 -6258
ALDOA -10796.0 -4574
ALDOB 2760.0 -1433
ALDOC -6280.0 -10161
ALOX12 7011.0 -3915
ALOX12B 8729.0 8897
ALOX15 5469.0 486
ALOX5 -4106.0 3491
ALOXE3 -5635.0 -79
AMACR -9836.0 -5719
AMD1 -9021.0 -9915
AMDHD1 11155.0 6105
AMN -10167.0 7581
AMPD2 -4481.0 -8931
AMPD3 12832.0 -9484
AMT 6745.0 8913
ANGPTL4 12903.0 -6065
AOC1 8076.0 6605
AOC2 -9694.0 -4120
AOC3 -9102.0 -649
AOX1 -8757.0 980
APIP -5270.0 9958
APOA1 -726.0 8518
APOC2 -135.0 3265
APOE 12058.0 12721
APOM 1204.0 8569
APRT 9297.0 12493
ARF1 -9163.0 -5561
ARF3 3251.0 -6648
ARG1 1715.0 -1184
ARG2 -11492.0 -11033
ARNT -9141.0 -10063
ARNT2 12715.0 -11191
ARNTL -4487.0 -3271
ARSA 11743.0 9589
ARSB 12086.0 -7494
ARSD 9745.0 -6384
ARSG 12508.0 -4208
ARSI -7529.0 -4701
ARSJ -8413.0 -8593
ARSK -2824.0 -7149
ARV1 2587.0 12259
AS3MT -2790.0 5436
ASAH1 -3293.0 6434
ASAH2 1536.0 -4922
ASL 12501.0 5148
ASNS -10878.0 12349
ASPA 5403.0 1602
ASRGL1 9236.0 582
ASS1 11521.0 -1872
ATIC -10939.0 1689
ATP5F1A 7998.0 -9624
ATP5F1B -8379.0 -9015
ATP5F1C -287.0 12518
ATP5F1D -1232.0 12979
ATP5F1E -1539.0 10947
ATP5MC1 10755.0 12985
ATP5MC2 -3774.0 12406
ATP5MC3 2759.0 11175
ATP5ME -5746.0 13136
ATP5MF -8135.0 13076
ATP5MG -6440.0 13061
ATP5PB 6563.0 -5803
ATP5PD -3802.0 13152
ATP5PF -6437.0 12713
ATP5PO -8733.0 12858
AUH 5719.0 5062
AZIN1 -8879.0 -10550
AZIN2 3795.0 3688
B3GALNT1 12351.0 -7110
B3GALT1 -3499.0 -5100
B3GALT4 10271.0 -5354
B3GALT5 12085.0 -9244
B3GALT6 11393.0 11355
B3GAT1 -914.0 2011
B3GAT2 -4097.0 5251
B3GAT3 11784.0 9103
B3GNT2 -4449.0 -8797
B3GNT3 8484.0 -3659
B3GNT4 -4093.0 -76
B3GNT7 11985.0 -6668
B4GALNT1 11773.0 7801
B4GALNT2 -2329.0 -6986
B4GALT1 -11375.0 -10725
B4GALT2 -10045.0 -4360
B4GALT3 -6120.0 -9469
B4GALT4 -4406.0 -8129
B4GALT5 12672.0 -9776
B4GALT6 -8212.0 -9561
B4GALT7 10562.0 -4980
B4GAT1 7603.0 7600
BAAT -3113.0 5632
BCAN 12079.0 -4013
BCAT1 -7644.0 -9371
BCAT2 -6548.0 8118
BCHE 7338.0 10241
BCKDHA 8458.0 -10040
BCKDHB 10575.0 160
BCKDK -4165.0 -6907
BCO2 4100.0 9439
BDH1 -7821.0 12097
BDH2 -5261.0 12093
BGN 11953.0 -1313
BHMT -547.0 5797
BHMT2 12451.0 10224
BLVRA -1722.0 9856
BLVRB -8667.0 9403
BPGM -11529.0 1553
BPHL -1802.0 10633
BPNT1 10007.0 -6778
BPNT2 9128.0 -9980
BRIP1 9999.0 3512
BSG -5149.0 12544
BST1 9555.0 -682
BTD 11562.0 -8185
CA12 12397.0 -8847
CA13 9451.0 6402
CA14 -8161.0 -4804
CA2 9840.0 -10284
CA3 -4535.0 8190
CA5B -8990.0 -60
CA6 809.0 2201
CA7 -733.0 324
CA9 -11518.0 -7389
CACNA1A 8256.0 12696
CACNA1C 11357.0 -4385
CACNA1D 12251.0 7919
CACNA1E 1707.0 1168
CACNA2D2 12046.0 3482
CACNB2 -2901.0 9935
CACNB3 -10750.0 131
CAD -7984.0 -10810
CALM1 11329.0 -6948
CARM1 -11211.0 -7070
CARNMT1 -7382.0 -7203
CARNS1 6990.0 326
CAV1 12654.0 -11158
CBR1 -9199.0 5166
CBR3 -7426.0 11814
CBR4 -8792.0 -3500
CBS 10907.0 11159
CBSL -586.0 5098
CCNC -7228.0 -7436
CD320 -6362.0 6079
CD36 -737.0 1067
CD38 -1924.0 1956
CD44 7044.0 -9772
CDA -2029.0 4632
CDIPT -8739.0 -6855
CDK19 -7762.0 -7499
CDK8 -8031.0 -9098
CDS1 -5536.0 -2686
CDS2 12495.0 -9650
CEMIP 12862.0 -11284
CEPT1 -2571.0 -8803
CERK -8014.0 -8517
CERS1 -1196.0 6704
CERS2 -7338.0 -10854
CERS4 -7329.0 -3137
CERS5 -9908.0 8789
CERS6 -8252.0 -10900
CERT1 -6444.0 -10761
CES1 -9352.0 13087
CES2 -1532.0 -9855
CES3 -2550.0 8219
CGA 4785.0 2191
CH25H 5534.0 10857
CHAC1 9833.0 11307
CHAC2 -3772.0 7542
CHAT 6776.0 -3180
CHD9 6368.0 -9728
CHDH 12135.0 8784
CHKA -9195.0 12581
CHKB 11206.0 12778
CHP1 10834.0 -7861
CHPF -11347.0 -6066
CHPF2 12137.0 9414
CHPT1 -2663.0 -5035
CHRM3 12228.0 -6966
CHST1 12515.0 -9456
CHST11 12103.0 -10187
CHST12 11011.0 10555
CHST13 11177.0 9777
CHST14 12268.0 10719
CHST15 12906.0 -11169
CHST2 -8741.0 -7886
CHST3 -2862.0 -10133
CHST5 3375.0 6783
CHST6 -4221.0 -9474
CHST7 -2403.0 -5448
CHST9 11110.0 -1231
CHSY1 3107.0 -10988
CHSY3 10102.0 -9769
CIAO1 -9220.0 10231
CIAO2B -5392.0 12629
CIAO3 803.0 11737
CIAPIN1 -2606.0 -6542
CKB 11133.0 11188
CKM -2654.0 386
CKMT1A 10958.0 11903
CKMT2 4895.0 -1910
CLOCK -5145.0 -9846
CMBL -11475.0 5764
CMPK1 -7140.0 -8337
CNDP2 -10063.0 -7916
COA1 11438.0 12298
COASY 10855.0 -4259
COMT -5537.0 11566
COQ10A 2060.0 8793
COQ10B -11071.0 1561
COQ2 2965.0 10768
COQ3 5953.0 9975
COQ5 10096.0 9326
COQ6 8027.0 12109
COQ7 -5430.0 7314
COQ9 -6427.0 10908
COX10 -10597.0 -6894
COX11 3872.0 -3998
COX14 -5296.0 7054
COX15 9353.0 -9310
COX16 -4741.0 10348
COX18 -7574.0 -2747
COX19 5255.0 5188
COX20 -9184.0 10961
COX4I1 -1716.0 13016
COX5A 8620.0 10682
COX5B -6531.0 13149
COX6A1 -1616.0 13101
COX6B1 -9124.0 13132
COX6C 5468.0 12965
COX7A2L -5446.0 -8229
COX7B -7400.0 13161
COX7C 9483.0 12599
COX8A -7227.0 12756
CPNE1 -7557.0 11964
CPNE3 -9909.0 -10952
CPNE7 217.0 12014
CPOX -9861.0 -9061
CPS1 -10630.0 6101
CPT1A 7772.0 -7257
CPT1B -5952.0 13011
CPT2 9375.0 -9508
CPTP 11350.0 10040
CRAT -7625.0 -9868
CREBBP -10387.0 -10534
CRLS1 -9065.0 -3075
CROT 6611.0 7925
CRYL1 -10609.0 -10098
CRYM -7062.0 2482
CS -9273.0 -10545
CSAD -3233.0 12728
CSGALNACT1 -750.0 -2738
CSGALNACT2 -10808.0 -10564
CSNK1G2 -9423.0 5261
CSNK2A1 -10604.0 -10586
CSNK2A2 -9949.0 -10332
CSNK2B -9249.0 12011
CSPG4 12459.0 -11273
CSPG5 545.0 -3163
CTH -3063.0 -3718
CTPS1 -3376.0 4124
CTPS2 -10393.0 -6489
CTRB2 -6012.0 4160
CTRC 1947.0 4683
CTSA 10901.0 -5855
CUBN 10733.0 10862
CYB5A 6459.0 10683
CYB5B 11510.0 10893
CYB5R3 -9040.0 -4520
CYC1 -8796.0 9550
CYCS -2044.0 10884
CYGB 12888.0 11069
CYP11A1 12765.0 -8287
CYP19A1 -1032.0 5862
CYP1A1 3546.0 6045
CYP1A2 -2545.0 5313
CYP1B1 -10765.0 -5640
CYP21A2 -92.0 3335
CYP24A1 -4338.0 -5656
CYP26A1 8741.0 7820
CYP26B1 12128.0 10216
CYP26C1 8826.0 -2625
CYP27A1 -8230.0 1966
CYP27B1 9511.0 -5684
CYP2B6 -3052.0 3621
CYP2D6 -989.0 9119
CYP2E1 -6219.0 8331
CYP2J2 4429.0 9256
CYP2R1 9448.0 4633
CYP2S1 8226.0 -4599
CYP2U1 8853.0 -5648
CYP2W1 4249.0 -1602
CYP39A1 5329.0 5740
CYP3A43 5593.0 -2743
CYP3A5 2707.0 6208
CYP46A1 7453.0 5231
CYP4F8 6270.0 -66
CYP4V2 5818.0 864
CYP51A1 -11252.0 -9071
CYP7B1 5761.0 -461
CYP8B1 -3521.0 3106
D2HGDH 8528.0 8058
DARS1 -10008.0 4483
DBH 9900.0 -1549
DBI 8149.0 12345
DBT -3782.0 -8648
DCK -10198.0 -7845
DCT -3537.0 2001
DCTD -9375.0 -9046
DCTPP1 -8574.0 -6485
DCXR -6370.0 12401
DDAH1 -6964.0 -7600
DDAH2 -9500.0 5750
DDHD1 -8454.0 -9590
DDHD2 -11261.0 -9027
DDO 2059.0 -137
DECR1 -3511.0 12026
DECR2 -7829.0 12111
DEGS1 6912.0 7355
DEGS2 11394.0 -1323
DERA 9303.0 2736
DGAT1 -3372.0 10410
DGAT2 -10973.0 9278
DGUOK 6144.0 12677
DHCR24 10141.0 -5101
DHCR7 -10620.0 -4740
DHFR 12668.0 12586
DHFR2 782.0 -5739
DHODH 7360.0 10538
DHRS7B -1339.0 12357
DHTKD1 -1810.0 -8372
DIO2 -8254.0 8806
DLAT -8123.0 -7745
DLD -9253.0 -8294
DLST -8194.0 -10831
DMAC2L 10867.0 2617
DMGDH 9315.0 3116
DNM2 -8486.0 -5605
DNPH1 10105.0 11763
DPYD 8870.0 -5791
DSE -8555.0 -10893
DSEL -10343.0 -356
DTYMK -8134.0 8022
DUOX1 6936.0 -3160
DUOX2 1184.0 -269
DUT 12336.0 10849
EBP -10085.0 10557
ECHS1 -11411.0 11233
ECI1 2788.0 11866
ECI2 -9692.0 -6771
ECSIT -6333.0 10114
EEF1E1 -10204.0 1084
EEFSEC 11184.0 -3492
EHHADH 8480.0 -8982
ELOVL1 -11072.0 -7190
ELOVL2 10313.0 -2466
ELOVL4 -6472.0 -6336
ELOVL5 -8932.0 -9605
ELOVL6 11756.0 -4557
ELOVL7 7136.0 -6795
ENO1 10742.0 -9306
ENO2 -4344.0 -7769
ENO3 -4079.0 11501
ENOPH1 -10785.0 1785
ENPP1 -6596.0 -3337
ENPP2 8991.0 2009
ENPP3 2888.0 572
ENPP6 -380.0 4251
ENTPD1 5547.0 -4297
ENTPD3 -11180.0 -5340
ENTPD4 -10501.0 10554
ENTPD5 10176.0 1379
ENTPD6 2650.0 4900
ENTPD7 -7652.0 -8631
ENTPD8 7530.0 10033
EP300 -9471.0 -10672
EPHX1 6496.0 11259
EPHX2 -4451.0 4247
EPM2A -7152.0 2522
EPRS1 1368.0 -10895
ERCC2 -6434.0 -1786
ESD -6134.0 -4610
ESRRA -11153.0 10724
ESYT1 8647.0 -10938
ESYT2 12481.0 -11207
ESYT3 9721.0 10425
ETFA -3727.0 -7917
ETFB -10912.0 576
ETFDH 2376.0 356
ETHE1 -10431.0 -6139
ETNK1 -6875.0 -4750
ETNK2 4136.0 -8591
EXT1 10114.0 -6275
EXT2 11023.0 -9224
FA2H 1994.0 1273
FAAH -5690.0 7992
FABP2 126.0 2676
FABP3 -8553.0 -4361
FABP5 11205.0 13058
FABP6 -3377.0 8934
FADS1 12050.0 -9601
FADS2 12638.0 -6478
FAH -6674.0 8819
FAHD1 -6287.0 7691
FAM120B 7228.0 -7376
FAR1 -4963.0 -4058
FAR2 7416.0 -5720
FASN -8601.0 -9423
FAU -8610.0 13102
FBP2 -4228.0 1232
FDFT1 -11448.0 -6461
FDPS -3650.0 10686
FDX1 -8625.0 8318
FDX2 -5678.0 10706
FDXR 6797.0 -10
FECH 11383.0 -7205
FH -396.0 11082
FHL2 10766.0 -7877
FIG4 10135.0 -5525
FITM1 5543.0 -1203
FITM2 10202.0 -8826
FLAD1 2160.0 10392
FLVCR1 3233.0 10
FOLH1 -7523.0 445
FPGS 10956.0 -4324
FTCD 6855.0 10549
FUT1 10043.0 -4555
FUT10 -10213.0 -7031
FUT11 6493.0 -8752
FUT2 8078.0 4687
FUT3 -8103.0 4300
FUT4 -11103.0 -9194
FUT6 5815.0 -592
FXN 3001.0 6244
G0S2 8280.0 10459
G6PC3 11270.0 11945
G6PD -6770.0 -3541
GAA 12540.0 -6361
GADL1 -795.0 -1006
GALC 11711.0 -7970
GALE 12776.0 12817
GALK1 -8218.0 -4824
GALT 3911.0 10632
GAMT 11210.0 12230
GAPDH 8544.0 -4543
GART -10887.0 -9545
GATM 11947.0 -7095
GBA 12033.0 4321
GBA2 10853.0 9195
GBA3 4649.0 -1483
GBE1 12790.0 -10994
GCAT -10028.0 11163
GCDH 6035.0 9903
GCH1 9093.0 -6765
GCHFR 12894.0 -5193
GCK -1708.0 4592
GCKR 2962.0 -1183
GCLC -7629.0 -8062
GCLM -8232.0 -8455
GCSH -6761.0 9913
GDA -2617.0 -773
GDE1 -5489.0 -5600
GDPD1 6538.0 -5821
GDPD3 -8814.0 10429
GDPD5 -5058.0 -4242
GGCT 9631.0 8227
GGPS1 -5726.0 -75
GGT1 9086.0 9992
GGT5 -4069.0 9731
GGT6 3650.0 393
GGT7 9413.0 7557
GK -11506.0 -277
GLA -4035.0 12059
GLB1 10162.0 -9240
GLB1L 10787.0 1974
GLCE -9839.0 -7514
GLDC 4017.0 -7420
GLIPR1 -11095.0 12768
GLO1 -8377.0 4629
GLP1R 9005.0 -2527
GLRX 12806.0 -339
GLRX5 -9519.0 11726
GLS -9356.0 -8809
GLS2 9366.0 2679
GLTP 294.0 -3070
GLUD1 -9514.0 -10318
GLUD2 -5197.0 -4510
GLUL 12531.0 -9935
GLYATL1 3821.0 802
GLYATL2 -1029.0 1059
GLYCTK 11002.0 8529
GM2A 11293.0 -4391
GMPR 11243.0 9305
GMPR2 9392.0 -3933
GMPS -4389.0 -7492
GNA11 -7494.0 -9222
GNA14 2396.0 -1461
GNA15 4887.0 -1938
GNAI1 -9053.0 -9191
GNAI2 -3839.0 -3626
GNAQ -5653.0 -8840
GNAS 8799.0 12628
GNB1 -8510.0 -10750
GNB2 -10836.0 -7224
GNB3 -5251.0 10539
GNB4 -6880.0 -9745
GNB5 9864.0 -5736
GNG10 -2116.0 6341
GNG11 -11165.0 11584
GNG12 -8091.0 -10696
GNG2 -9822.0 -5394
GNG4 12509.0 262
GNG5 -2592.0 10603
GNG7 10314.0 5271
GNGT2 8291.0 1587
GNMT -1375.0 5139
GNPAT -3027.0 5570
GNPDA1 -9604.0 -8425
GNPDA2 -8436.0 -4994
GNS 11099.0 -11125
GOT1 -251.0 7784
GOT2 11173.0 841
GPAM 9347.0 -8178
GPAT2 -3610.0 6349
GPAT3 -3147.0 -8656
GPAT4 -9453.0 -6583
GPC1 1951.0 -7922
GPC2 -3913.0 -3279
GPC4 11190.0 -8942
GPC5 7673.0 -3135
GPC6 -6095.0 -11229
GPCPD1 -11362.0 12472
GPD1 1.0 6256
GPD1L -393.0 5259
GPD2 8694.0 -9821
GPHN -1949.0 -10361
GPI -9581.0 -7088
GPS2 -7300.0 12877
GPT 8865.0 9142
GPT2 8365.0 7519
GPX1 7862.0 12387
GPX2 2218.0 3022
GPX4 -10566.0 12566
GRHL1 9277.0 -206
GRHPR -6215.0 8320
GSR -11433.0 -4996
GSS 11218.0 9939
GSTA4 -6690.0 -1181
GSTK1 12523.0 11152
GSTM1 6083.0 8492
GSTM2 1645.0 10470
GSTM3 -7719.0 8050
GSTM4 10485.0 9146
GSTO1 -8782.0 12837
GSTO2 1449.0 4256
GSTP1 -9254.0 12602
GSTT2 -2234.0 3992
GSTT2B 9459.0 11851
GSTZ1 10777.0 8707
GUK1 -9476.0 10188
GUSB 9430.0 8910
GYG1 10629.0 -8829
GYG2 10117.0 -1505
GYS1 -8713.0 -8373
HAAO 8688.0 9133
HACD1 5363.0 1605
HACD2 -4771.0 -8602
HACD3 9333.0 -10814
HACD4 2499.0 4283
HACL1 9746.0 -6929
HADH -9269.0 10963
HADHA 10596.0 -8030
HADHB -424.0 -8570
HAGH 10014.0 11571
HAL -3269.0 4475
HAS2 -11561.0 -9065
HAS3 11539.0 -8568
HDAC3 10500.0 -7476
HELZ2 6737.0 -11221
HEXA 12426.0 6143
HEXB 1770.0 -1985
HIBADH 2089.0 8513
HIBCH -2666.0 969
HILPDA 12823.0 -6351
HK1 8176.0 -10566
HK2 5513.0 -11103
HLCS 1981.0 -7850
HMBS -6797.0 11970
HMGCL -5305.0 -5204
HMGCR -9941.0 -10570
HMGCS1 -10536.0 -9535
HMMR 6132.0 1294
HMOX1 -11186.0 -1600
HMOX2 -10454.0 1742
HNMT -1649.0 3699
HOGA1 1298.0 5341
HPD 1912.0 5180
HPGD 6500.0 1008
HPRT1 358.0 -259
HPSE -6814.0 -4898
HS2ST1 -858.0 -10708
HS3ST3A1 -11441.0 -8358
HS3ST3B1 -11527.0 -10530
HS3ST4 11403.0 4734
HS3ST5 8627.0 -3934
HS3ST6 -3230.0 6911
HS6ST1 -8821.0 -6022
HS6ST2 12471.0 -6831
HS6ST3 -6685.0 5510
HSCB -10466.0 7562
HSD11B1 11024.0 -4770
HSD11B2 5780.0 3705
HSD17B1 3773.0 5477
HSD17B10 2620.0 11931
HSD17B11 -9945.0 -2869
HSD17B12 -8890.0 -8865
HSD17B13 -317.0 7872
HSD17B14 9553.0 9653
HSD17B2 -5849.0 -5013
HSD17B3 6008.0 9432
HSD17B4 12326.0 883
HSD17B7 -7606.0 7172
HSD17B8 6130.0 -2864
HSD3B1 1099.0 -4781
HSD3B2 561.0 -4405
HSD3B7 -8631.0 -5807
HSP90AA1 11397.0 -7534
HSP90AB1 -9168.0 -9114
HSPG2 -9046.0 -9768
HTD2 -3789.0 -5185
HYAL1 4794.0 556
HYAL2 7029.0 10799
HYAL3 429.0 9382
HYKK -4392.0 9854
IARS1 -2182.0 -9570
IDH1 -8291.0 -2632
IDH2 -11009.0 -7176
IDH3A -8898.0 -3067
IDH3B -4300.0 -4551
IDH3G 117.0 9128
IDI1 -10047.0 -6271
IDO2 4265.0 2865
IDS 8178.0 -10132
IDUA 11538.0 11620
IL4I1 -11099.0 -4396
IMPA1 -5510.0 -6525
IMPA2 -9466.0 -8384
IMPDH1 -8676.0 -5498
IMPDH2 -9060.0 -9748
INMT 9444.0 -4952
INPP1 9905.0 3038
INPP4A -6949.0 -8897
INPP4B 7799.0 1151
INPP5A -5057.0 -8151
INPP5B 12347.0 -6141
INPP5D 12494.0 -6335
INPP5E -9231.0 9571
INPP5F -6267.0 -8385
INPP5J 2774.0 6306
INPP5K -2145.0 5151
INPPL1 -7710.0 -4327
INSIG1 -8247.0 -10291
INSIG2 7660.0 -8487
IP6K1 -6152.0 -6742
IP6K2 -2736.0 8348
IPMK -4650.0 -8547
IPPK -7804.0 6703
IQGAP1 -11188.0 -11226
ISCA1 -7587.0 -4971
ISCA2 2253.0 4958
ISCU -6298.0 10132
ISYNA1 -5583.0 12774
ITPA 5034.0 11916
ITPK1 -4577.0 11119
ITPKA -10540.0 2290
ITPKB 6953.0 -9629
ITPKC -11063.0 -7089
ITPR1 -11523.0 -11275
ITPR2 -7642.0 -10382
ITPR3 969.0 -10878
IVD 12121.0 -4420
IYD -351.0 5080
KARS1 -10243.0 9778
KCNB1 6281.0 6918
KCNG2 7474.0 2092
KCNJ11 -6079.0 -3756
KCNS3 9811.0 -6261
KDSR -10284.0 -10628
KHK 6482.0 -1164
KMO 7390.0 6829
KPNB1 6085.0 -9326
KYAT1 -5720.0 2274
KYAT3 10416.0 -9152
KYNU -2499.0 6757
L2HGDH 7092.0 -9403
LARS1 -7999.0 -5859
LBR 10617.0 -8863
LCLAT1 -5766.0 -9874
LDHA -4687.0 -9205
LDHAL6A -1233.0 5274
LDHAL6B 5276.0 -3235
LDHB 3274.0 2139
LDLR -1005.0 -10920
LGMN -5791.0 -7132
LHB 5241.0 1674
LHPP 11470.0 6527
LIAS -9105.0 5143
LIPE 8482.0 4384
LIPH 3458.0 5131
LIPT1 -8180.0 2538
LIPT2 -2271.0 5033
LMBRD1 -8193.0 -7829
LPCAT1 -3028.0 -5868
LPCAT2 -5840.0 -6904
LPCAT3 12306.0 8926
LPCAT4 -10814.0 11636
LPGAT1 9789.0 -9221
LPIN1 -10795.0 -5721
LPIN2 7561.0 -11087
LPIN3 3240.0 9122
LPL -11212.0 -8638
LRAT 3496.0 3064
LRP1 11313.0 -10721
LRP10 12875.0 -11287
LRP12 -10595.0 -11129
LRP2 8899.0 -2352
LRP8 8189.0 -9203
LRPPRC -7531.0 -9086
LSS -6494.0 -7687
LTA4H -9399.0 -7128
LYPLA1 -3476.0 -11176
LYRM4 -3448.0 10228
MAN2B1 8035.0 -9988
MAN2B2 12075.0 -5833
MAN2C1 12005.0 11813
MANBA -10376.0 7010
MAOA -3391.0 -5960
MAOB 6834.0 8909
MAPKAPK2 -3317.0 -7911
MARCKS -3690.0 -8784
MARS1 -1476.0 10979
MAT1A -6091.0 2828
MAT2A 12784.0 -5987
MAT2B -6792.0 -8563
MBOAT1 -7369.0 -4354
MBOAT2 -9788.0 -8124
MBOAT7 4107.0 -7700
MBTPS1 12152.0 -6413
MBTPS2 6403.0 -10090
MCAT -8937.0 4501
MCCC1 12225.0 -6790
MCCC2 8284.0 -1797
MCEE -6643.0 -2102
MDH1 10483.0 11132
MDH2 -10661.0 -8768
ME1 6821.0 -7488
ME2 -10992.0 -10086
ME3 -8506.0 7768
MECR 9196.0 4995
MED1 4565.0 -10954
MED10 -10647.0 -1516
MED11 4180.0 11924
MED12 9393.0 -7619
MED13 4175.0 -11032
MED13L -6849.0 -10882
MED14 -9534.0 -10023
MED15 -8873.0 1271
MED16 -208.0 -5452
MED17 -8560.0 -6232
MED18 -5111.0 7388
MED19 -8211.0 667
MED20 -7954.0 -6157
MED21 -8801.0 -5810
MED22 11643.0 -4252
MED23 1919.0 -8179
MED24 11859.0 -4035
MED25 -8951.0 9901
MED26 -9943.0 -4811
MED27 -3930.0 5130
MED28 11227.0 4963
MED29 -6262.0 -3527
MED30 1643.0 6767
MED31 -7376.0 12435
MED4 -701.0 7901
MED6 -5208.0 8573
MED7 9232.0 10734
MED8 775.0 -6428
MED9 -9036.0 3469
MFSD2A -11012.0 3357
MGLL 12726.0 -10604
MGST1 -2552.0 11591
MGST2 12190.0 12958
MGST3 7748.0 11703
MID1IP1 8046.0 -7581
MIGA1 -4880.0 -10227
MIGA2 -8827.0 11729
MINPP1 6106.0 -7890
MIOX -1281.0 3564
MLX -6671.0 1703
MLXIPL -8313.0 11156
MLYCD 9540.0 -2921
MMAA -10781.0 -2769
MMAB 8184.0 11228
MMACHC 5568.0 9309
MMADHC -9569.0 -8402
MMS19 7089.0 -7187
MMUT -8807.0 -9656
MOCOS 12767.0 -9173
MOCS1 11325.0 -1330
MOCS2 10711.0 12705
MOCS3 9294.0 -2193
MOGAT3 -1059.0 4237
MORC2 -7120.0 6149
MPC1 -6561.0 11380
MPC2 -5160.0 7935
MPST -4372.0 12019
MRI1 -8262.0 9899
MSMO1 -10896.0 -7985
MT-ATP6 8420.0 13018
MT-ATP8 9404.0 12604
MT-CO1 9067.0 13178
MT-CO2 8603.0 13180
MT-CO3 8245.0 13176
MT-CYB 5991.0 13184
MT-ND1 5209.0 13177
MT-ND2 -1457.0 13183
MT-ND3 6571.0 13181
MT-ND4 566.0 13174
MT-ND5 4289.0 13012
MT-ND6 4676.0 13045
MTAP 5134.0 6545
MTARC1 8013.0 4260
MTARC2 4356.0 7988
MTF1 -8718.0 -10119
MTHFD1 -7182.0 10303
MTHFD1L -8578.0 -8322
MTHFD2 -8994.0 -7194
MTHFD2L -3480.0 9174
MTHFR -7668.0 -6396
MTHFS 385.0 11563
MTM1 -4584.0 -7808
MTMR1 10448.0 -7007
MTMR10 9939.0 -6395
MTMR12 -10618.0 -11138
MTMR14 -5165.0 7975
MTMR2 -6094.0 -9336
MTMR3 -7836.0 -10186
MTMR4 -4934.0 -8877
MTMR6 -5385.0 -8925
MTMR7 -5015.0 4886
MTMR9 -9350.0 -8112
MTR 92.0 -9742
MTRR -8284.0 -8513
MVD -8157.0 -5861
MVK -6968.0 8489
N6AMT1 7099.0 10581
NAALAD2 7668.0 8036
NADK 8707.0 11437
NADK2 -7715.0 -8326
NADSYN1 10561.0 10871
NAGLU 12163.0 -5299
NAGS 11887.0 -8985
NAMPT 7134.0 -10751
NAPRT -7216.0 11398
NAT1 -2142.0 7115
NAT8L -4195.0 -9350
NAXD 3182.0 9993
NAXE 6657.0 10443
NCAN 3533.0 -1773
NCOA1 4263.0 -8396
NCOA2 -6710.0 -10904
NCOA3 -11270.0 -11034
NCOA6 -1205.0 -9301
NCOR1 -8203.0 -6322
NCOR2 12175.0 -9615
NDC1 -5800.0 -9199
NDOR1 9246.0 12234
NDST1 8645.0 -10698
NDST2 -5061.0 -9644
NDST3 1659.0 3776
NDUFA1 -6222.0 13127
NDUFA10 -7241.0 -4285
NDUFA11 9807.0 12851
NDUFA12 6720.0 13048
NDUFA13 -4424.0 12971
NDUFA2 5937.0 13125
NDUFA3 -4508.0 13084
NDUFA4 9132.0 11345
NDUFA5 -6593.0 11094
NDUFA6 -10640.0 12901
NDUFA7 8872.0 13143
NDUFA8 -8774.0 12900
NDUFA9 2605.0 10360
NDUFAB1 -10558.0 8746
NDUFAF1 2883.0 9463
NDUFAF2 -5167.0 12574
NDUFAF3 10175.0 13112
NDUFAF4 -8760.0 9608
NDUFAF5 -3460.0 9719
NDUFAF6 -5625.0 10508
NDUFAF7 6751.0 8883
NDUFB1 8092.0 13163
NDUFB10 -9687.0 12582
NDUFB11 -7090.0 11583
NDUFB2 11367.0 12511
NDUFB3 1661.0 12046
NDUFB4 8888.0 13008
NDUFB5 -3244.0 -5075
NDUFB6 -8238.0 12165
NDUFB7 -4205.0 12444
NDUFB8 8367.0 13039
NDUFB9 -8544.0 12805
NDUFC1 -7186.0 12437
NDUFC2 -5184.0 11409
NDUFS1 -9609.0 -7041
NDUFS2 3967.0 -10068
NDUFS3 -8653.0 12725
NDUFS4 6388.0 3949
NDUFS5 -6394.0 13145
NDUFS6 -6327.0 12108
NDUFS7 5531.0 12411
NDUFS8 -7989.0 12773
NDUFV1 -5404.0 8980
NDUFV2 -6865.0 13148
NDUFV3 -6779.0 12304
NEU1 -9477.0 3790
NEU2 8005.0 -3528
NEU3 -10525.0 -8697
NEU4 -5702.0 3121
NFS1 -8587.0 -4816
NFYA -10786.0 -9963
NFYB -5919.0 7739
NFYC -3340.0 12311
NHLRC1 9210.0 6494
NME1 11440.0 13153
NME2 -5201.0 12533
NME3 -5191.0 12634
NME4 -8955.0 12904
NMNAT1 9753.0 -6068
NMNAT2 12841.0 -10949
NMNAT3 7770.0 7639
NMRAL1 -6580.0 12010
NMRK1 5933.0 11386
NNMT 12760.0 12864
NNT 4483.0 -10790
NOS3 476.0 -957
NOSIP -8746.0 12178
NOSTRIN 5575.0 2554
NPAS2 12099.0 11727
NQO1 12497.0 12065
NQO2 -6513.0 11746
NR1D1 -10996.0 4719
NR1H2 -3062.0 778
NR1H3 10799.0 11178
NRF1 -9525.0 -5711
NSDHL -3016.0 8446
NT5C 10036.0 12101
NT5C1A 1781.0 1506
NT5C1B -1290.0 -1463
NT5C2 4767.0 9082
NT5C3A -10068.0 -3760
NT5E 12820.0 -11134
NT5M -9526.0 10535
NUBP1 2370.0 12120
NUBP2 -10078.0 11001
NUBPL 8039.0 -8010
NUDT1 3652.0 12359
NUDT10 -7704.0 -4998
NUDT11 -10991.0 -6828
NUDT12 -1385.0 3226
NUDT13 8578.0 6754
NUDT15 -1862.0 8736
NUDT16 12651.0 -4262
NUDT18 5922.0 -1638
NUDT19 -4582.0 -4496
NUDT3 10097.0 -10288
NUDT4 -7741.0 -7716
NUDT5 12333.0 10972
NUDT7 -4018.0 -3308
NUDT9 -3389.0 11891
NUP107 10317.0 11210
NUP133 6251.0 -8590
NUP153 -8447.0 -10433
NUP155 1534.0 -10720
NUP160 -10172.0 -9854
NUP188 -11151.0 -5029
NUP205 12369.0 -7848
NUP210 12856.0 -5260
NUP214 -6331.0 -6303
NUP35 -10251.0 8114
NUP37 3092.0 10117
NUP42 8137.0 9137
NUP43 -7490.0 9638
NUP50 -10234.0 -3947
NUP54 -10563.0 -8348
NUP58 -7370.0 -10308
NUP62 -5900.0 -6034
NUP85 7849.0 10502
NUP88 -10968.0 2131
NUP93 -6918.0 -6255
NUP98 -10847.0 -10135
OAT 10923.0 -3605
OAZ1 -5995.0 8537
OAZ2 12305.0 -4736
OAZ3 -4681.0 -2934
OCA2 11312.0 -5329
OCRL -3909.0 -8515
ODC1 -11548.0 -8715
OGDH -5384.0 -7828
OLAH 3779.0 -3519
OMD 2559.0 1901
OPLAH 11715.0 8476
ORMDL1 -10616.0 11044
ORMDL2 10809.0 11899
ORMDL3 7073.0 -1824
OSBP -11432.0 -11066
OSBPL10 12422.0 -10923
OSBPL1A 7299.0 -9190
OSBPL2 -7654.0 -6073
OSBPL3 11559.0 -9445
OSBPL5 -8362.0 -5759
OSBPL6 -10479.0 -991
OSBPL7 11008.0 10084
OSBPL8 -6521.0 -10242
OSBPL9 -4447.0 -7265
OXCT1 7426.0 -6662
OXCT2 3882.0 8410
PAICS -8896.0 -7785
PANK1 -4929.0 -7711
PANK2 7613.0 1651
PANK3 -4780.0 -10399
PANK4 -7723.0 2162
PAOX 10273.0 -5165
PAPSS1 -10307.0 -3927
PAPSS2 6847.0 -10771
PARP10 -9582.0 8696
PARP14 11854.0 -6808
PARP16 -79.0 -5042
PARP4 12757.0 -10992
PARP6 -7943.0 9905
PARP8 12354.0 -8651
PARP9 12239.0 -4266
PC 10642.0 -7758
PCBD1 10442.0 9074
PCCA 11484.0 -7458
PCCB 2928.0 -5796
PCK1 3254.0 4600
PCK2 11395.0 -398
PCTP 12215.0 -8293
PCYT1A 1479.0 -5733
PCYT2 -7783.0 12466
PDHA1 -10664.0 11842
PDHB -3368.0 12152
PDHX -9039.0 -4928
PDK1 -5018.0 -9225
PDK2 11377.0 2039
PDK3 -6613.0 -8798
PDK4 10934.0 -3798
PDP1 11745.0 -9417
PDP2 -8514.0 -8538
PDPR -6645.0 -8103
PDSS1 5649.0 8667
PDSS2 -4701.0 -6190
PDXK -11035.0 -5417
PDZD11 10212.0 12640
PECR 7959.0 7794
PEMT -5793.0 8198
PEX11A -3152.0 -1150
PFAS 10370.0 10384
PFKFB1 3220.0 5029
PFKFB2 1610.0 -3293
PFKFB3 12759.0 -11276
PFKFB4 12732.0 8429
PFKL -5109.0 -8972
PFKM -7607.0 -7918
PFKP -384.0 -10110
PGAM1 3645.0 -10719
PGAM2 1166.0 -1455
PGD -7202.0 -354
PGK1 9259.0 -11156
PGLS 7112.0 12391
PGM1 12049.0 -11238
PGM2 -11358.0 -9219
PGM2L1 -11266.0 -9885
PGP 8613.0 12495
PGS1 -5196.0 -5724
PHGDH 10381.0 12550
PHKA1 2980.0 -8258
PHKA2 -9682.0 11144
PHKB 10976.0 -3464
PHKG1 2679.0 9646
PHKG2 -2952.0 12137
PHOSPHO1 -4356.0 8844
PHYH 8745.0 2071
PHYKPL 12650.0 4336
PI4K2A -7282.0 -6755
PI4K2B -4371.0 -7468
PI4KA 10503.0 -5896
PI4KB 5739.0 -10289
PIAS4 -9983.0 -3860
PIK3C2A -5604.0 -9519
PIK3C2B 7510.0 -6252
PIK3C3 -8170.0 -7865
PIK3CA -5426.0 -9599
PIK3CB -9217.0 -10250
PIK3CD 8125.0 -9524
PIK3CG 8376.0 -5110
PIK3R1 10169.0 -9568
PIK3R2 -6506.0 -5848
PIK3R3 9654.0 -3457
PIK3R4 9611.0 -9422
PIK3R5 -1767.0 107
PIK3R6 12716.0 -2472
PIKFYVE -10388.0 -10306
PIP4K2A 8236.0 -8090
PIP4K2B -3399.0 1126
PIP4K2C 8425.0 -9498
PIP5K1A 7428.0 -9178
PIP5K1B 6218.0 -6738
PIP5K1C -7525.0 -1015
PIPOX 3326.0 -2663
PISD -10547.0 4750
PITPNB -10732.0 -8304
PITPNM1 -9832.0 -10911
PITPNM2 -6158.0 -4679
PITPNM3 462.0 2559
PKM 9491.0 -8585
PLA1A 1097.0 1226
PLA2G10 301.0 4728
PLA2G12A 8760.0 -7403
PLA2G15 -6553.0 -5088
PLA2G4A -11353.0 -9250
PLA2G4B 6200.0 13064
PLA2G4C 9981.0 -5934
PLA2G4D 1634.0 4664
PLA2G5 -11263.0 7586
PLA2G6 -8707.0 12727
PLA2R1 12453.0 -6182
PLAAT1 2388.0 -4908
PLAAT3 12878.0 12588
PLAAT4 10410.0 12384
PLB1 -664.0 4620
PLBD1 12507.0 39
PLCB2 370.0 6728
PLCB3 -6925.0 -1610
PLCB4 11654.0 3834
PLCD1 8414.0 -5958
PLCD3 10005.0 -5698
PLCD4 -1787.0 3553
PLCE1 9674.0 -3943
PLCG1 -8518.0 10852
PLCG2 -6464.0 -3252
PLCH1 -4082.0 -4387
PLCH2 5087.0 -8743
PLD1 12766.0 -9763
PLD2 -7320.0 -7936
PLD3 9531.0 -3623
PLD4 2571.0 7880
PLD6 -11240.0 -2847
PLEKHA1 -5829.0 -10175
PLEKHA2 -11451.0 -10431
PLEKHA3 -9653.0 -6310
PLEKHA4 -3065.0 10468
PLEKHA5 -8831.0 -7991
PLEKHA6 10937.0 7485
PLEKHA8 5033.0 -9481
PLIN1 -6085.0 2234
PLIN2 12727.0 -5631
PLIN3 -6142.0 -11153
PLPP1 -8524.0 -1473
PLPP2 11795.0 9587
PLPP3 12490.0 -10087
PLPP6 6732.0 -6196
PMVK 8931.0 4934
PNMT 6175.0 5951
PNP -10127.0 -10176
PNPLA2 -6634.0 -2945
PNPLA3 -9617.0 -8407
PNPLA4 -2168.0 3810
PNPLA6 -9579.0 -4893
PNPLA7 4383.0 9842
PNPLA8 -10281.0 -8614
PNPO 10866.0 1005
PODXL2 1240.0 10387
POLD1 10830.0 8156
POM121 -8878.0 -9749
POM121C -9406.0 -9089
PON2 11322.0 1907
POR -10842.0 374
PPA1 -5474.0 -3678
PPA2 -8673.0 6936
PPARA -8366.0 -11101
PPARD -11069.0 6617
PPARG 12799.0 9364
PPARGC1A 10444.0 -5499
PPARGC1B -11191.0 -6465
PPAT -10102.0 -9936
PPCDC 11861.0 11034
PPCS -1448.0 9746
PPIP5K1 12627.0 -1301
PPIP5K2 1304.0 -10134
PPM1K -9252.0 -7689
PPM1L -7048.0 -9180
PPOX 8950.0 11264
PPP1CA 4929.0 7585
PPP1CB -5856.0 -9212
PPP1CC -9143.0 -9771
PPP1R3C 10573.0 -5635
PPP2CA -3124.0 -7225
PPP2CB -11374.0 -10028
PPP2R1A -9193.0 -4828
PPP2R1B 6255.0 -5465
PPP2R5D -11383.0 -11113
PPT1 9505.0 -3741
PPT2 6099.0 -1615
PRELP 4474.0 2215
PRKAA2 -3279.0 -8609
PRKAB2 -7701.0 -10925
PRKACA 8250.0 9679
PRKACB 8849.0 -9614
PRKAG2 9883.0 -5624
PRKAR1A 8600.0 -10630
PRKAR1B 8608.0 -4934
PRKAR2A -5980.0 -10943
PRKAR2B -9276.0 -5166
PRKCA 12366.0 -10396
PRKD1 10025.0 -8707
PRKD2 -7712.0 -10335
PRKD3 3551.0 -10820
PRKG2 95.0 -2178
PRODH 4648.0 8935
PRPS1 -4640.0 -7852
PRPS2 -10777.0 -5424
PRSS1 -6231.0 725
PRSS3 -11534.0 -3851
PRXL2B 2450.0 2967
PSAP 10899.0 -11185
PSAT1 -8575.0 11575
PSMA1 -9646.0 10578
PSMA2 -4002.0 -4430
PSMA3 -5668.0 12561
PSMA4 -9907.0 11447
PSMA5 5538.0 826
PSMA6 -3328.0 8997
PSMA7 -10164.0 -7607
PSMB1 -6139.0 12480
PSMB10 9537.0 11663
PSMB2 -3364.0 8976
PSMB3 7905.0 13078
PSMB4 -1370.0 12998
PSMB5 -6937.0 -2970
PSMB6 -6537.0 10901
PSMB7 -8656.0 12462
PSMB8 -9783.0 11153
PSMB9 -9810.0 10733
PSMC1 -3547.0 -3814
PSMC2 -9185.0 11068
PSMC3 -1273.0 12327
PSMC4 -7156.0 12714
PSMC5 7024.0 12041
PSMC6 -7069.0 697
PSMD1 -9192.0 -10441
PSMD10 -6869.0 1286
PSMD11 7720.0 -8518
PSMD12 813.0 8775
PSMD13 -5300.0 12140
PSMD14 -10615.0 8461
PSMD2 -6801.0 -10378
PSMD3 -8058.0 -4798
PSMD4 743.0 11756
PSMD5 -9642.0 -8039
PSMD6 -7577.0 12228
PSMD7 -6198.0 -6043
PSMD8 -9103.0 -6526
PSMD9 -7638.0 -3346
PSME1 -8654.0 11878
PSME2 -4231.0 12869
PSME3 11811.0 -7813
PSME4 -10581.0 -10843
PSMF1 -7549.0 -4369
PSPH 11422.0 7040
PSTK 5756.0 9314
PTDSS1 -4830.0 -8543
PTDSS2 10798.0 5487
PTEN -6933.0 -8533
PTGDS 5712.0 -326
PTGES -10205.0 12283
PTGES2 8987.0 10737
PTGES3 -9501.0 -9810
PTGIS -4112.0 -2751
PTGR1 12337.0 -7704
PTGR2 11100.0 8783
PTGS2 -7696.0 -11040
PTPMT1 -6485.0 12300
PTPN13 12622.0 -7833
PTS -1728.0 12054
PUDP 5935.0 -5772
PXMP2 10630.0 4583
PYCR1 -4927.0 -11012
PYCR2 9765.0 12269
PYGB -11296.0 -9947
PYGL -8006.0 -10425
PYGM 859.0 5254
QARS1 10134.0 -6688
QDPR 11360.0 -6120
QPRT -11532.0 9751
RAB14 -9162.0 -10367
RAB4A 6470.0 -4166
RAB5A -7843.0 -8483
RAE1 -7356.0 -5016
RAN -5185.0 5548
RANBP2 -5941.0 -10334
RAP1A -1904.0 -6372
RAPGEF3 -9262.0 -7226
RAPGEF4 5782.0 8179
RARS1 -9720.0 -7252
RBKS 11087.0 5114
RBP1 11319.0 11694
RBP4 10591.0 11534
RDH11 -10607.0 -304
RETSAT -2685.0 -8033
RFK -4905.0 -6715
RGL1 12783.0 -10360
RHCE 214.0 -4595
RHD 808.0 1770
RIDA -72.0 11337
RIMKLA 12748.0 -8994
RIMKLB -8314.0 347
RNLS 266.0 751
RORA -161.0 -8980
RPE -6092.0 -5602
RPIA -1807.0 -4134
RPL10 -3821.0 1597
RPL10A -9707.0 -8212
RPL11 -8529.0 12382
RPL12 -9329.0 12992
RPL13 -3469.0 12598
RPL13A -6854.0 6955
RPL14 -6386.0 13137
RPL15 -786.0 12153
RPL17 -8989.0 12909
RPL18 -6672.0 12800
RPL18A -6976.0 11926
RPL19 3924.0 12911
RPL21 -6322.0 5141
RPL22 -5554.0 9520
RPL22L1 -10448.0 12221
RPL23 5769.0 12922
RPL23A 11361.0 -5257
RPL24 -4591.0 12995
RPL26 -8797.0 12658
RPL26L1 -9387.0 12770
RPL27 6735.0 11625
RPL27A -7818.0 13051
RPL28 -5809.0 12962
RPL29 -4515.0 12915
RPL3 -6827.0 -4535
RPL30 -3907.0 11096
RPL31 -8781.0 13131
RPL32 -5028.0 12983
RPL34 -9357.0 12996
RPL35 -8027.0 13097
RPL35A -1449.0 12789
RPL36 -8818.0 12868
RPL36A -4480.0 13009
RPL36AL -8216.0 12702
RPL37 -4624.0 13134
RPL37A -9347.0 12675
RPL38 1558.0 13140
RPL39 -6168.0 11962
RPL39L -6608.0 -6269
RPL3L -510.0 7904
RPL4 11351.0 12558
RPL41 -4616.0 -6074
RPL5 4679.0 12075
RPL6 -6903.0 12730
RPL7 -3327.0 -8789
RPL7A -6163.0 11708
RPL8 -7572.0 10323
RPL9 -9659.0 12806
RPLP0 -1504.0 -7331
RPLP1 9026.0 12731
RPLP2 -8225.0 12999
RPS10 -8384.0 10665
RPS11 -7725.0 12935
RPS12 -7872.0 11600
RPS13 -9450.0 12652
RPS14 -1180.0 12428
RPS15 -7430.0 12908
RPS15A -8754.0 12989
RPS16 -3844.0 12941
RPS17 -10534.0 11631
RPS18 -9122.0 12984
RPS19 -7633.0 12888
RPS2 -10222.0 8916
RPS20 -4961.0 13095
RPS21 -3001.0 13022
RPS23 6940.0 11907
RPS24 2369.0 13034
RPS25 -9371.0 12690
RPS26 -2615.0 13114
RPS27 651.0 11270
RPS27A 5357.0 6464
RPS27L 7330.0 12750
RPS28 2716.0 12485
RPS29 -652.0 9078
RPS3 -7756.0 12135
RPS3A -9170.0 5257
RPS4X -8542.0 12239
RPS5 -6283.0 -7965
RPS6 -9225.0 12405
RPS7 5142.0 12976
RPS8 -5812.0 12745
RPS9 -8815.0 10189
RPSA 292.0 11576
RRM1 6359.0 -7531
RRM2 12419.0 -2007
RRM2B -1200.0 -8759
RTEL1 11373.0 11890
RUFY1 -2346.0 11546
RXRA -9975.0 -6008
RXRB -9927.0 -7550
SACM1L -7553.0 -7666
SAMD8 -7692.0 -9284
SAMHD1 11969.0 -4728
SAR1B 6713.0 9055
SARDH 11797.0 -2513
SARS1 10748.0 -9421
SAT1 -11516.0 8580
SBF1 -7013.0 -7405
SBF2 -7579.0 -11053
SC5D -9936.0 -9554
SCAP 10207.0 -6793
SCD -6967.0 -8469
SCD5 -8562.0 -8561
SCLY -9481.0 10671
SCO1 -10631.0 -6537
SCO2 -9739.0 9526
SCP2 11683.0 -5644
SDC1 12230.0 -7104
SDC2 -6754.0 -5737
SDC3 12401.0 -6760
SDC4 12322.0 -10633
SDHA -10480.0 -9986
SDHB -299.0 5982
SDHC 9345.0 -5559
SDHD -9641.0 -2716
SDS 3809.0 3212
SDSL 11650.0 4044
SEC13 -9702.0 -8646
SEC23A 6211.0 -11247
SEC24A 8771.0 -11248
SEC24B -10249.0 -10349
SEC24C 8468.0 -11142
SEC24D -11430.0 -11236
SECISBP2 11207.0 -6517
SEH1L -9333.0 -5653
SELENOI -6323.0 -9929
SEM1 -9978.0 13108
SEPHS2 8103.0 -351
SEPSECS -6443.0 -5096
SERINC1 -8559.0 -10927
SERINC2 12901.0 -4299
SERINC3 -9690.0 -10718
SERINC5 -10855.0 -10123
SERPINA6 5214.0 7999
SGMS1 -3969.0 -9918
SGMS2 9854.0 -8817
SGPL1 -6129.0 -9743
SGPP1 -3002.0 -9260
SGPP2 -3985.0 7799
SGSH 11466.0 8231
SHMT1 10041.0 12191
SHMT2 7127.0 150
SHPK -9246.0 -7292
SIN3A 9736.0 -10233
SIN3B -7946.0 11143
SLC16A1 -10562.0 -9859
SLC16A3 11791.0 -6452
SLC19A1 9060.0 8496
SLC19A2 -6303.0 -8882
SLC19A3 -3908.0 3914
SLC22A1 1198.0 3444
SLC22A13 -648.0 2062
SLC22A5 3024.0 2375
SLC23A1 3168.0 3672
SLC23A2 6485.0 -5846
SLC25A1 -6507.0 7710
SLC25A10 10535.0 10876
SLC25A11 6783.0 9521
SLC25A12 9436.0 5342
SLC25A13 12236.0 -4102
SLC25A14 4056.0 10282
SLC25A15 -8051.0 -6219
SLC25A16 9109.0 12013
SLC25A17 -10034.0 281
SLC25A19 -9222.0 11652
SLC25A20 8585.0 -5523
SLC25A21 1939.0 -353
SLC25A27 10480.0 12786
SLC25A28 -2674.0 12676
SLC25A32 -5445.0 -9505
SLC25A37 -9868.0 12952
SLC25A44 8439.0 -6942
SLC26A1 7040.0 3908
SLC26A2 -4295.0 -10449
SLC27A1 4552.0 -6579
SLC27A2 10536.0 -569
SLC27A3 11824.0 2868
SLC27A5 8599.0 9718
SLC2A1 12313.0 -10164
SLC2A3 -6111.0 -11283
SLC35B2 9973.0 -9792
SLC35B3 -7199.0 -6153
SLC35D1 1678.0 -8747
SLC35D2 10637.0 -6268
SLC36A4 -1600.0 -8668
SLC37A1 -5220.0 -5226
SLC37A2 12828.0 -1380
SLC37A4 -6962.0 9471
SLC3A2 -9319.0 -3436
SLC44A1 3030.0 -8195
SLC44A2 11423.0 -6429
SLC44A3 9846.0 -2785
SLC44A5 8809.0 -7261
SLC46A1 11747.0 -4346
SLC51A -3285.0 5328
SLC51B 9192.0 -4447
SLC52A1 -3647.0 4492
SLC52A2 -7721.0 -5238
SLC52A3 1848.5 3302
SLC5A5 5760.0 4246
SLC5A6 -9022.0 7606
SLC6A11 10785.0 -3525
SLC6A12 -4244.0 1206
SLC6A8 12417.0 -9058
SLC7A5 -9076.0 -4839
SLC9A1 8241.0 -5276
SLCO1B3 6971.0 -2291
SMARCD3 11978.0 11422
SMOX -3994.0 -11021
SMPD1 -8640.0 -6846
SMPD2 -7448.0 8682
SMPD3 7325.0 10000
SMPD4 -8916.0 9507
SMS -11167.0 -1993
SNAP25 11071.0 12085
SORD -9421.0 -8553
SP1 -10121.0 -9960
SPHK1 -11193.0 -9551
SPHK2 996.0 -3963
SPNS2 6707.0 3611
SPR -4539.0 9702
SPTLC1 -8629.0 -8361
SPTLC2 -7631.0 -10853
SPTLC3 7149.0 -1127
SPTSSA -3187.0 -2030
SPTSSB -483.0 241
SQLE -11257.0 -9793
SRD5A1 -7401.0 -5993
SRD5A3 6201.0 -9627
SREBF1 8797.0 11668
SREBF2 -10833.0 -10659
SRM -7150.0 11902
SRR -6159.0 7210
ST3GAL1 12199.0 -11061
ST3GAL2 9077.0 -8211
ST3GAL3 -7104.0 -4100
ST3GAL4 -9632.0 6643
ST3GAL6 -11458.0 -3139
ST6GALNAC6 -10366.0 -4890
STARD10 -11280.0 10122
STARD3 -3161.0 -529
STARD3NL 11304.0 -7611
STARD4 -3584.0 -8370
STARD5 7138.0 8173
STARD6 4681.0 -390
STARD7 5228.0 -9022
STK11 -8395.0 11292
STS 6761.0 -3002
STX1A -10779.0 11790
STXBP1 -9033.0 -10503
SUCLA2 3325.0 -7651
SUCLG1 1114.0 10597
SUCLG2 -6338.0 -8917
SULT1A1 1568.0 8030
SULT1A2 2933.0 -775
SULT1A3 -3988.0 10985
SULT1A4 -5014.0 6668
SULT1B1 -7930.0 3832
SULT1C2 9680.0 12144
SULT1C4 6652.0 -925
SULT2A1 3725.0 1880
SULT4A1 -7305.0 12214
SUMF1 11852.0 -4769
SUMF2 11753.0 -9338
SUMO2 -4403.0 -3595
SUOX 11819.0 9645
SURF1 8003.0 9112
SYNJ1 -6939.0 -6072
SYNJ2 7547.0 -5487
SYT5 -10749.0 -3988
TACO1 8239.0 8081
TALDO1 -9895.0 11544
TAT 4699.0 448
TAZ 8218.0 12600
TBL1X -8568.0 -8247
TBL1XR1 -3958.0 -9641
TBXAS1 11359.0 12456
TCN2 -7499.0 -1779
TDO2 8914.0 5887
TECR 6238.0 12948
TGS1 -7713.0 -7446
THEM4 12470.0 11368
THRAP3 -6692.0 -5191
THTPA 11609.0 -6656
TIAM2 606.0 -5687
TIMMDC1 9211.0 -3329
TK1 8640.0 12195
TK2 11223.0 11430
TKFC 10845.0 -2395
TKT -10316.0 1857
TM7SF2 9323.0 12506
TMEM126B -8036.0 9815
TMEM186 -8187.0 5086
TMEM86B -4684.0 10657
TMLHE 10560.0 -7649
TNFAIP8 -8871.0 -5353
TNFAIP8L1 -9972.0 -6812
TNFAIP8L3 6293.0 3816
TNFRSF21 9967.0 -10315
TPH1 3976.0 9198
TPH2 -308.0 7806
TPI1 9519.0 -7935
TPK1 11149.0 -4885
TPMT -9585.0 5970
TPO 4072.0 7357
TPR 8761.0 -5834
TPST1 7014.0 -8349
TPST2 -10253.0 -10663
TRAP1 -11197.0 8602
TRIB3 -3221.0 -5552
TRMT112 -5741.0 13057
TSPO -10371.0 4351
TST 9957.0 10661
TTPA 8342.0 2897
TTR -212.0 1928
TXN -7456.0 12957
TXN2 -8694.0 3274
TXNRD1 -10964.0 -9955
TYMP 12562.0 8603
TYMS 7752.0 511
UBA52 -6807.0 11639
UBB -5602.0 12024
UBC -10397.0 7017
UBE2I -10489.0 6476
UBIAD1 -9372.0 -6426
UCK1 -6591.0 10329
UCK2 6859.0 -5920
UCKL1 8998.0 12133
UCP2 11830.0 11257
UCP3 2795.0 9619
UGCG -1667.0 -7173
UGDH -9991.0 -9957
UGP2 12203.0 -10131
UGT1A1 56.0 2625
UGT1A7 2395.0 8771
UGT3A2 7384.0 5628
UGT8 10288.0 -6424
UMPS -2365.0 -3118
UPB1 7539.0 -1133
UPP1 -7882.0 -5275
UQCR10 -9028.0 12920
UQCR11 -5675.0 11509
UQCRB -979.0 12923
UQCRC1 8588.0 -1762
UQCRC2 -11089.0 -6026
UQCRFS1 -10915.0 -8657
UQCRH -8039.0 12733
UQCRQ 10244.0 13147
UROD 9947.0 12213
UROS 11889.0 11662
UST -6346.0 -8615
VAC14 -9751.0 -7774
VAMP2 -5460.0 9876
VAPA -10099.0 -8584
VAPB 10592.0 -8499
VCAN -1861.0 -11263
VDAC1 10321.0 -414
VDR 11798.0 -1940
VKORC1 -4765.0 -4020
VKORC1L1 -10554.0 -8838
VNN1 -2091.0 -4
VNN2 6843.0 4353
WASL -8668.0 -8587
XDH -6425.0 -6418
XYLB 3022.0 6371
XYLT1 -11081.0 -10705
XYLT2 10574.0 -7316
ZDHHC21 -2971.0 -2436





Resolution of D-Loop Structures

Resolution of D-Loop Structures
metric value
setSize 33
pMANOVA 0.00394
p.adjustMANOVA 0.0043
s.dist 0.35
s.KO 0.241
s.drug 0.253
p.KO 0.0166
p.drug 0.0118




Top 20 genes
Gene KO drug
EME1 11398 12799
XRCC3 10913 12963
RTEL1 11373 11890
XRCC2 11675 11504
GEN1 10900 11539
EXO1 11028 10237
RAD51C 10266 10960
DNA2 9182 12016
RAD51AP1 10184 7752
BRCA1 11931 5883
RAD51D 11272 5949
BRIP1 9999 3512
SLX4 9703 2427
RMI2 1967 10674

Click HERE to show all gene set members

All member genes
KO drug
ATM -300 -6012
BARD1 -7617 -5249
BLM -1023 11586
BRCA1 11931 5883
BRCA2 6854 -3764
BRIP1 9999 3512
DNA2 9182 12016
EME1 11398 12799
EME2 -5775 11911
EXO1 11028 10237
GEN1 10900 11539
KAT5 -9469 672
MRE11 -556 11374
MUS81 -2750 11766
NBN -3430 -8967
PALB2 -9017 -5142
RAD50 5490 -7933
RAD51 11416 -2838
RAD51AP1 10184 7752
RAD51B 7746 -2133
RAD51C 10266 10960
RAD51D 11272 5949
RBBP8 -9239 6461
RMI1 8716 -4304
RMI2 1967 10674
RTEL1 11373 11890
SLX1A -6724 11853
SLX4 9703 2427
SPIDR 11752 -3698
TOP3A -7604 -6411
WRN -10934 -5815
XRCC2 11675 11504
XRCC3 10913 12963





Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-56                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.2.0          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.2             rvest_1.0.2           
##  [22] haven_2.4.3            xfun_0.30              crayon_1.5.0          
##  [25] RCurl_1.98-1.6         jsonlite_1.8.0         genefilter_1.74.1     
##  [28] survival_3.3-1         glue_1.6.2             polyclip_1.10-0       
##  [31] gtable_0.3.0           zlibbioc_1.38.0        XVector_0.32.0        
##  [34] webshot_0.5.2          DelayedArray_0.18.0    scales_1.1.1          
##  [37] DBI_1.1.2              Rcpp_1.0.8.2           viridisLite_0.4.0     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.2             RColorBrewer_1.1-2     ellipsis_0.3.2        
##  [46] farver_2.1.0           pkgconfig_2.0.3        reshape_0.8.8         
##  [49] XML_3.99-0.9           sass_0.4.0             dbplyr_2.1.1          
##  [52] locfit_1.5-9.5         utf8_1.2.2             labeling_0.4.2        
##  [55] tidyselect_1.1.2       rlang_1.0.2            later_1.3.0           
##  [58] AnnotationDbi_1.54.1   munsell_0.5.0          cellranger_1.1.0      
##  [61] tools_4.2.0            cachem_1.0.6           cli_3.2.0             
##  [64] generics_0.1.2         RSQLite_2.2.10         broom_0.7.12          
##  [67] evaluate_0.15          fastmap_1.1.0          yaml_2.3.5            
##  [70] knitr_1.37             bit64_4.0.5            fs_1.5.2              
##  [73] caTools_1.18.2         KEGGREST_1.32.0        mime_0.12             
##  [76] xml2_1.3.3             compiler_4.2.0         rstudioapi_0.13       
##  [79] png_0.1-7              reprex_2.0.1           geneplotter_1.70.0    
##  [82] bslib_0.3.1            stringi_1.7.6          highr_0.9             
##  [85] desc_1.4.1             lattice_0.20-45        Matrix_1.4-1          
##  [88] vctrs_0.3.8            pillar_1.7.0           lifecycle_1.0.1       
##  [91] jquerylib_0.1.4        data.table_1.14.2      bitops_1.0-7          
##  [94] httpuv_1.6.5           R6_2.5.1               promises_1.2.0.1      
##  [97] KernSmooth_2.23-20     gridExtra_2.3          assertthat_0.2.1      
## [100] rprojroot_2.0.2        withr_2.5.0            GenomeInfoDbData_1.2.6
## [103] hms_1.1.1              grid_4.2.0             rmarkdown_2.13        
## [106] shiny_1.7.1            lubridate_1.8.0

END of report