Mitch Report

date generated: 2021-02-09

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                x
## STK25   15.96852
## CCDC80  15.13535
## TLR4   -11.86789
## TFB2M  -10.84115
## SH2B3  -10.74626
## MRGBP  -10.27617

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2444
num_genes_in_profile	15982
duplicated_genes_present	0
num_profile_genes_in_sets	7215
num_profile_genes_not_in_sets	8767

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2444
num_genesets_excluded	1144
num_genesets_included	1300

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Interleukin-35 Signalling	10	2.52e-04	0.668	3.28e-03
Peptide chain elongation	85	1.38e-24	0.642	1.79e-21
Viral mRNA Translation	85	4.65e-24	0.634	1.93e-21
Selenocysteine synthesis	88	3.64e-24	0.625	1.93e-21
Eukaryotic Translation Elongation	89	7.42e-24	0.617	1.93e-21
Eukaryotic Translation Termination	89	2.09e-22	0.597	3.89e-20
Selenoamino acid metabolism	101	6.14e-24	0.581	1.93e-21
Response of EIF2AK4 (GCN2) to amino acid deficiency	97	9.13e-23	0.577	1.98e-20
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	91	1.49e-20	0.563	1.79e-18
Interleukin-6 signaling	11	1.28e-03	0.561	1.08e-02
Formation of a pool of free 40S subunits	97	1.39e-21	0.560	2.27e-19
Activation of BAD and translocation to mitochondria	12	8.12e-04	-0.558	7.71e-03
Signaling by Leptin	10	2.69e-03	0.548	1.79e-02
Chemokine receptors bind chemokines	13	9.71e-04	0.528	8.89e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	2.57e-03	-0.525	1.77e-02
L13a-mediated translational silencing of Ceruloplasmin expression	107	8.22e-21	0.523	1.19e-18
RHO GTPases activate KTN1	10	4.53e-03	-0.518	2.53e-02
Degradation of cysteine and homocysteine	11	2.96e-03	-0.517	1.87e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	108	1.51e-20	0.517	1.79e-18
Synthesis of PIPs at the Golgi membrane	15	5.86e-04	-0.513	6.40e-03
RHO GTPases activate IQGAPs	10	5.31e-03	-0.509	2.80e-02
MAPK3 (ERK1) activation	10	5.48e-03	0.507	2.86e-02
Synthesis of PIPs at the early endosome membrane	15	8.04e-04	-0.500	7.69e-03
tRNA processing in the mitochondrion	24	3.01e-05	-0.492	5.50e-04
SRP-dependent cotranslational protein targeting to membrane	108	2.11e-18	0.487	2.29e-16
Cap-dependent Translation Initiation	115	2.62e-18	0.471	2.44e-16
Eukaryotic Translation Initiation	115	2.62e-18	0.471	2.44e-16
Early Phase of HIV Life Cycle	12	4.77e-03	-0.471	2.62e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	4.98e-03	-0.468	2.68e-02
Interleukin-7 signaling	17	8.95e-04	0.465	8.43e-03
MicroRNA (miRNA) biogenesis	23	1.20e-04	-0.463	1.98e-03
G beta:gamma signalling through CDC42	13	4.23e-03	-0.458	2.44e-02
G-protein beta:gamma signalling	20	4.05e-04	-0.457	4.96e-03
Listeria monocytogenes entry into host cells	19	6.52e-04	-0.452	6.83e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	4.84e-03	-0.451	2.63e-02
G beta:gamma signalling through PI3Kgamma	15	2.78e-03	-0.446	1.79e-02
CRMPs in Sema3A signaling	14	3.87e-03	-0.446	2.32e-02
Post-chaperonin tubulin folding pathway	15	2.94e-03	-0.444	1.86e-02
Growth hormone receptor signaling	19	9.89e-04	0.436	8.97e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	111	2.87e-15	0.434	2.33e-13
Nonsense-Mediated Decay (NMD)	111	2.87e-15	0.434	2.33e-13
Activation of G protein gated Potassium channels	13	6.78e-03	-0.434	3.27e-02
G protein gated Potassium channels	13	6.78e-03	-0.434	3.27e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	13	6.78e-03	-0.434	3.27e-02
Regulation of IFNA signaling	11	1.31e-02	0.432	5.31e-02
Notch-HLH transcription pathway	25	2.12e-04	-0.428	2.93e-03
Establishment of Sister Chromatid Cohesion	11	1.42e-02	-0.427	5.56e-02
Gluconeogenesis	25	2.33e-04	-0.425	3.19e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	5.71e-05	-0.425	1.02e-03
Suppression of phagosomal maturation	12	1.21e-02	-0.418	5.13e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Interleukin-35 Signalling	10	2.52e-04	0.668000	3.28e-03
Peptide chain elongation	85	1.38e-24	0.642000	1.79e-21
Viral mRNA Translation	85	4.65e-24	0.634000	1.93e-21
Selenocysteine synthesis	88	3.64e-24	0.625000	1.93e-21
Eukaryotic Translation Elongation	89	7.42e-24	0.617000	1.93e-21
Eukaryotic Translation Termination	89	2.09e-22	0.597000	3.89e-20
Selenoamino acid metabolism	101	6.14e-24	0.581000	1.93e-21
Response of EIF2AK4 (GCN2) to amino acid deficiency	97	9.13e-23	0.577000	1.98e-20
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	91	1.49e-20	0.563000	1.79e-18
Interleukin-6 signaling	11	1.28e-03	0.561000	1.08e-02
Formation of a pool of free 40S subunits	97	1.39e-21	0.560000	2.27e-19
Activation of BAD and translocation to mitochondria	12	8.12e-04	-0.558000	7.71e-03
Signaling by Leptin	10	2.69e-03	0.548000	1.79e-02
Chemokine receptors bind chemokines	13	9.71e-04	0.528000	8.89e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	2.57e-03	-0.525000	1.77e-02
L13a-mediated translational silencing of Ceruloplasmin expression	107	8.22e-21	0.523000	1.19e-18
RHO GTPases activate KTN1	10	4.53e-03	-0.518000	2.53e-02
Degradation of cysteine and homocysteine	11	2.96e-03	-0.517000	1.87e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	108	1.51e-20	0.517000	1.79e-18
Synthesis of PIPs at the Golgi membrane	15	5.86e-04	-0.513000	6.40e-03
RHO GTPases activate IQGAPs	10	5.31e-03	-0.509000	2.80e-02
MAPK3 (ERK1) activation	10	5.48e-03	0.507000	2.86e-02
Synthesis of PIPs at the early endosome membrane	15	8.04e-04	-0.500000	7.69e-03
tRNA processing in the mitochondrion	24	3.01e-05	-0.492000	5.50e-04
SRP-dependent cotranslational protein targeting to membrane	108	2.11e-18	0.487000	2.29e-16
Cap-dependent Translation Initiation	115	2.62e-18	0.471000	2.44e-16
Eukaryotic Translation Initiation	115	2.62e-18	0.471000	2.44e-16
Early Phase of HIV Life Cycle	12	4.77e-03	-0.471000	2.62e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	4.98e-03	-0.468000	2.68e-02
Interleukin-7 signaling	17	8.95e-04	0.465000	8.43e-03
MicroRNA (miRNA) biogenesis	23	1.20e-04	-0.463000	1.98e-03
G beta:gamma signalling through CDC42	13	4.23e-03	-0.458000	2.44e-02
G-protein beta:gamma signalling	20	4.05e-04	-0.457000	4.96e-03
Listeria monocytogenes entry into host cells	19	6.52e-04	-0.452000	6.83e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	4.84e-03	-0.451000	2.63e-02
G beta:gamma signalling through PI3Kgamma	15	2.78e-03	-0.446000	1.79e-02
CRMPs in Sema3A signaling	14	3.87e-03	-0.446000	2.32e-02
Post-chaperonin tubulin folding pathway	15	2.94e-03	-0.444000	1.86e-02
Growth hormone receptor signaling	19	9.89e-04	0.436000	8.97e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	111	2.87e-15	0.434000	2.33e-13
Nonsense-Mediated Decay (NMD)	111	2.87e-15	0.434000	2.33e-13
Activation of G protein gated Potassium channels	13	6.78e-03	-0.434000	3.27e-02
G protein gated Potassium channels	13	6.78e-03	-0.434000	3.27e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	13	6.78e-03	-0.434000	3.27e-02
Regulation of IFNA signaling	11	1.31e-02	0.432000	5.31e-02
Notch-HLH transcription pathway	25	2.12e-04	-0.428000	2.93e-03
Establishment of Sister Chromatid Cohesion	11	1.42e-02	-0.427000	5.56e-02
Gluconeogenesis	25	2.33e-04	-0.425000	3.19e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	5.71e-05	-0.425000	1.02e-03
Suppression of phagosomal maturation	12	1.21e-02	-0.418000	5.13e-02
InlB-mediated entry of Listeria monocytogenes into host cell	15	5.20e-03	-0.417000	2.75e-02
RAS processing	17	3.03e-03	-0.415000	1.90e-02
Spry regulation of FGF signaling	16	4.24e-03	-0.413000	2.44e-02
Formation of the ternary complex, and subsequently, the 43S complex	49	6.03e-07	0.412000	2.01e-05
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	7.51e-03	-0.399000	3.50e-02
Cytosolic iron-sulfur cluster assembly	11	2.28e-02	-0.397000	7.59e-02
Negative regulation of FGFR3 signaling	22	1.31e-03	-0.396000	1.10e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	1.37e-02	-0.395000	5.45e-02
Triglyceride metabolism	20	2.29e-03	-0.394000	1.65e-02
Basigin interactions	18	3.90e-03	-0.393000	2.32e-02
RUNX3 regulates NOTCH signaling	14	1.10e-02	-0.392000	4.76e-02
PKMTs methylate histone lysines	40	1.76e-05	-0.392000	3.64e-04
ATF6 (ATF6-alpha) activates chaperone genes	10	3.19e-02	0.392000	9.62e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	22	1.50e-03	-0.391000	1.22e-02
Metabolism of nitric oxide: NOS3 activation and regulation	12	1.97e-02	-0.389000	6.94e-02
ERKs are inactivated	13	1.57e-02	-0.387000	5.82e-02
Repression of WNT target genes	12	2.09e-02	-0.385000	7.22e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	7.72e-03	-0.385000	3.55e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	7.72e-03	-0.385000	3.55e-02
Activation of BH3-only proteins	26	7.48e-04	-0.382000	7.39e-03
rRNA processing in the mitochondrion	26	7.61e-04	-0.381000	7.39e-03
Glyoxylate metabolism and glycine degradation	20	3.18e-03	-0.381000	1.98e-02
EGFR downregulation	27	6.19e-04	-0.381000	6.57e-03
RHO GTPases Activate WASPs and WAVEs	32	2.05e-04	-0.379000	2.87e-03
Gastrin-CREB signalling pathway via PKC and MAPK	14	1.41e-02	-0.379000	5.54e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.50e-02	-0.376000	5.65e-02
Regulation of MECP2 expression and activity	29	4.68e-04	-0.375000	5.68e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	19	4.64e-03	-0.375000	2.57e-02
Neurodegenerative Diseases	19	4.64e-03	-0.375000	2.57e-02
Telomere C-strand synthesis initiation	11	3.23e-02	-0.373000	9.65e-02
Thromboxane signalling through TP receptor	15	1.26e-02	-0.372000	5.21e-02
Deactivation of the beta-catenin transactivating complex	39	5.89e-05	-0.372000	1.02e-03
The role of Nef in HIV-1 replication and disease pathogenesis	20	4.06e-03	-0.371000	2.39e-02
Ribosomal scanning and start codon recognition	56	1.95e-06	0.368000	5.77e-05
Prostacyclin signalling through prostacyclin receptor	11	3.54e-02	-0.366000	1.02e-01
Translation initiation complex formation	56	2.18e-06	0.366000	6.28e-05
ATF6 (ATF6-alpha) activates chaperones	12	2.88e-02	0.364000	8.94e-02
Negative regulation of FGFR4 signaling	21	3.86e-03	-0.364000	2.32e-02
PRC2 methylates histones and DNA	13	2.31e-02	-0.364000	7.67e-02
S33 mutants of beta-catenin aren’t phosphorylated	15	1.48e-02	-0.364000	5.60e-02
S37 mutants of beta-catenin aren’t phosphorylated	15	1.48e-02	-0.364000	5.60e-02
S45 mutants of beta-catenin aren’t phosphorylated	15	1.48e-02	-0.364000	5.60e-02
Signaling by CTNNB1 phospho-site mutants	15	1.48e-02	-0.364000	5.60e-02
Signaling by GSK3beta mutants	15	1.48e-02	-0.364000	5.60e-02
T41 mutants of beta-catenin aren’t phosphorylated	15	1.48e-02	-0.364000	5.60e-02
SHC-mediated cascade:FGFR3	10	4.67e-02	-0.363000	1.21e-01
Ephrin signaling	19	6.40e-03	-0.361000	3.20e-02
Diseases of mitotic cell cycle	36	1.80e-04	-0.361000	2.67e-03
Thrombin signalling through proteinase activated receptors (PARs)	21	4.32e-03	-0.360000	2.45e-02
Pausing and recovery of Tat-mediated HIV elongation	25	1.91e-03	-0.359000	1.43e-02
Tat-mediated HIV elongation arrest and recovery	25	1.91e-03	-0.359000	1.43e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	21	4.44e-03	-0.359000	2.50e-02
Collagen biosynthesis and modifying enzymes	50	1.18e-05	0.358000	2.48e-04
ERBB2 Regulates Cell Motility	10	5.02e-02	-0.358000	1.28e-01
Scavenging by Class A Receptors	10	5.07e-02	0.357000	1.29e-01
MET activates RAP1 and RAC1	10	5.12e-02	-0.356000	1.30e-01
Mismatch Repair	15	1.79e-02	-0.353000	6.48e-02
SUMOylation of transcription cofactors	40	1.13e-04	-0.353000	1.89e-03
APC truncation mutants have impaired AXIN binding	14	2.26e-02	-0.352000	7.55e-02
AXIN missense mutants destabilize the destruction complex	14	2.26e-02	-0.352000	7.55e-02
Signaling by AMER1 mutants	14	2.26e-02	-0.352000	7.55e-02
Signaling by APC mutants	14	2.26e-02	-0.352000	7.55e-02
Signaling by AXIN mutants	14	2.26e-02	-0.352000	7.55e-02
Truncations of AMER1 destabilize the destruction complex	14	2.26e-02	-0.352000	7.55e-02
HIV elongation arrest and recovery	27	1.59e-03	-0.351000	1.28e-02
Pausing and recovery of HIV elongation	27	1.59e-03	-0.351000	1.28e-02
Sema3A PAK dependent Axon repulsion	15	1.87e-02	-0.351000	6.68e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	6.70e-03	-0.350000	3.27e-02
Interleukin-20 family signaling	15	1.91e-02	0.350000	6.79e-02
G beta:gamma signalling through BTK	10	5.59e-02	-0.349000	1.39e-01
Collagen chain trimerization	29	1.18e-03	0.348000	1.03e-02
Inhibition of DNA recombination at telomere	19	8.91e-03	-0.347000	4.00e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	35	3.94e-04	-0.346000	4.88e-03
Pre-NOTCH Transcription and Translation	33	5.90e-04	-0.346000	6.40e-03
Negative regulation of MET activity	20	7.54e-03	-0.345000	3.50e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	2.55e-02	-0.345000	8.16e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	57	6.73e-06	0.345000	1.56e-04
Removal of the Flap Intermediate	14	2.58e-02	-0.344000	8.20e-02
SUMOylation of DNA methylation proteins	14	2.58e-02	-0.344000	8.20e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	3.25e-02	0.342000	9.66e-02
Defective EXT2 causes exostoses 2	13	3.25e-02	0.342000	9.66e-02
Citric acid cycle (TCA cycle)	21	6.61e-03	-0.342000	3.24e-02
Formation of tubulin folding intermediates by CCT/TriC	18	1.23e-02	-0.341000	5.19e-02
Regulation of expression of SLITs and ROBOs	158	1.62e-13	0.340000	1.17e-11
Postmitotic nuclear pore complex (NPC) reformation	27	2.22e-03	-0.340000	1.62e-02
G alpha (12/13) signalling events	59	6.92e-06	-0.339000	1.58e-04
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	1.31e-02	-0.338000	5.31e-02
Regulation of pyruvate dehydrogenase (PDH) complex	15	2.39e-02	-0.337000	7.81e-02
Processive synthesis on the lagging strand	15	2.39e-02	-0.337000	7.81e-02
Gap junction degradation	10	6.55e-02	-0.336000	1.52e-01
Interleukin-10 signaling	25	3.62e-03	0.336000	2.22e-02
RHO GTPases activate PKNs	28	2.15e-03	-0.335000	1.59e-02
ADP signalling through P2Y purinoceptor 12	13	3.68e-02	-0.335000	1.04e-01
Nuclear Envelope (NE) Reassembly	66	2.88e-06	-0.333000	7.97e-05
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	24	4.79e-03	-0.333000	2.62e-02
Sulfur amino acid metabolism	21	8.67e-03	-0.331000	3.90e-02
Assembly of collagen fibrils and other multimeric structures	45	1.31e-04	0.330000	2.12e-03
Regulation of beta-cell development	22	7.61e-03	-0.329000	3.52e-02
RA biosynthesis pathway	13	4.07e-02	0.328000	1.12e-01
Synthesis of PIPs at the late endosome membrane	11	6.02e-02	-0.327000	1.46e-01
Signaling by FGFR1	38	4.91e-04	-0.327000	5.75e-03
Uptake and function of anthrax toxins	11	6.10e-02	-0.326000	1.47e-01
Sema4D in semaphorin signaling	22	8.11e-03	-0.326000	3.70e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	7.43e-02	-0.326000	1.65e-01
Collagen formation	71	2.22e-06	0.325000	6.28e-05
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	6.22e-02	-0.325000	1.47e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23	7.21e-03	-0.324000	3.42e-02
Cell-extracellular matrix interactions	15	3.00e-02	-0.324000	9.27e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	1.26e-02	-0.322000	5.21e-02
HS-GAG biosynthesis	24	6.39e-03	0.322000	3.20e-02
Trafficking and processing of endosomal TLR	10	7.87e-02	0.321000	1.73e-01
Interferon alpha/beta signaling	45	1.96e-04	0.321000	2.77e-03
SUMOylation of transcription factors	18	1.86e-02	-0.320000	6.68e-02
ROS and RNS production in phagocytes	21	1.12e-02	-0.320000	4.79e-02
Complex I biogenesis	52	7.46e-05	-0.318000	1.28e-03
Influenza Viral RNA Transcription and Replication	130	4.21e-10	0.317000	2.38e-08
Vpr-mediated nuclear import of PICs	33	1.84e-03	-0.313000	1.43e-02
Sema4D induced cell migration and growth-cone collapse	18	2.14e-02	-0.313000	7.36e-02
Negative regulation of FGFR2 signaling	22	1.13e-02	-0.312000	4.81e-02
Cohesin Loading onto Chromatin	10	8.87e-02	-0.311000	1.86e-01
Constitutive Signaling by Overexpressed ERBB2	10	8.94e-02	-0.310000	1.87e-01
SHC1 events in EGFR signaling	10	9.05e-02	-0.309000	1.89e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.43e-02	-0.309000	5.58e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.43e-02	-0.309000	5.58e-02
Receptor-type tyrosine-protein phosphatases	18	2.43e-02	0.307000	7.88e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF	35	1.71e-03	-0.306000	1.34e-02
Signaling by RAS mutants	35	1.71e-03	-0.306000	1.34e-02
Signaling by moderate kinase activity BRAF mutants	35	1.71e-03	-0.306000	1.34e-02
Signaling downstream of RAS mutants	35	1.71e-03	-0.306000	1.34e-02
Prefoldin mediated transfer of substrate to CCT/TriC	23	1.10e-02	-0.306000	4.76e-02
Signaling by WNT in cancer	32	2.74e-03	-0.306000	1.79e-02
Activation of kainate receptors upon glutamate binding	16	3.43e-02	-0.306000	1.00e-01
Pre-NOTCH Processing in Golgi	14	4.79e-02	-0.305000	1.23e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	42	6.21e-04	-0.305000	6.57e-03
Regulation of actin dynamics for phagocytic cup formation	50	1.89e-04	-0.305000	2.77e-03
Voltage gated Potassium channels	18	2.61e-02	0.303000	8.25e-02
Negative regulation of FGFR1 signaling	24	1.06e-02	-0.301000	4.61e-02
Major pathway of rRNA processing in the nucleolus and cytosol	175	7.35e-12	0.300000	4.78e-10
Triglyceride catabolism	14	5.26e-02	-0.299000	1.32e-01
G-protein activation	14	5.27e-02	-0.299000	1.32e-01
TP53 Regulates Transcription of Cell Cycle Genes	44	6.04e-04	-0.299000	6.49e-03
EPHB-mediated forward signaling	32	3.45e-03	-0.299000	2.12e-02
CASP8 activity is inhibited	10	1.02e-01	0.299000	2.06e-01
Dimerization of procaspase-8	10	1.02e-01	0.299000	2.06e-01
Regulation by c-FLIP	10	1.02e-01	0.299000	2.06e-01
Olfactory Signaling Pathway	10	1.03e-01	-0.298000	2.07e-01
Transport of Ribonucleoproteins into the Host Nucleus	31	4.19e-03	-0.297000	2.43e-02
Interactions of Vpr with host cellular proteins	36	2.05e-03	-0.297000	1.53e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	35	2.42e-03	-0.296000	1.69e-02
HIV Transcription Elongation	35	2.42e-03	-0.296000	1.69e-02
Tat-mediated elongation of the HIV-1 transcript	35	2.42e-03	-0.296000	1.69e-02
NOTCH1 Intracellular Domain Regulates Transcription	46	5.18e-04	-0.296000	5.96e-03
Binding and Uptake of Ligands by Scavenger Receptors	17	3.47e-02	0.296000	1.01e-01
FRS-mediated FGFR3 signaling	12	7.66e-02	-0.295000	1.69e-01
SUMOylation of ubiquitinylation proteins	37	1.90e-03	-0.295000	1.43e-02
Glucagon-type ligand receptors	17	3.53e-02	-0.295000	1.02e-01
Formation of Fibrin Clot (Clotting Cascade)	13	6.57e-02	0.295000	1.52e-01
Constitutive Signaling by AKT1 E17K in Cancer	24	1.24e-02	-0.295000	5.21e-02
Formation of HIV elongation complex in the absence of HIV Tat	37	1.96e-03	-0.294000	1.47e-02
Signaling by ERBB2 TMD/JMD mutants	16	4.26e-02	-0.293000	1.15e-01
DNA Damage/Telomere Stress Induced Senescence	28	7.51e-03	-0.292000	3.50e-02
Cholesterol biosynthesis	24	1.36e-02	0.291000	5.41e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	48	4.85e-04	-0.291000	5.73e-03
p38MAPK events	11	9.51e-02	-0.291000	1.95e-01
AKT phosphorylates targets in the cytosol	13	6.98e-02	-0.290000	1.59e-01
Intrinsic Pathway for Apoptosis	46	6.59e-04	-0.290000	6.85e-03
Pre-NOTCH Expression and Processing	47	5.81e-04	-0.290000	6.40e-03
Interactions of Rev with host cellular proteins	36	2.60e-03	-0.290000	1.77e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	6.06e-02	-0.290000	1.46e-01
G beta:gamma signalling through PLC beta	12	8.28e-02	-0.289000	1.78e-01
Presynaptic function of Kainate receptors	12	8.28e-02	-0.289000	1.78e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	1.14e-01	-0.289000	2.26e-01
SUMOylation of SUMOylation proteins	34	3.69e-03	-0.288000	2.25e-02
CLEC7A (Dectin-1) induces NFAT activation	11	9.85e-02	-0.288000	2.01e-01
Transcriptional regulation by small RNAs	46	7.40e-04	-0.288000	7.39e-03
Signaling by TGF-beta Receptor Complex	71	2.88e-05	-0.287000	5.43e-04
Signaling by FGFR4	30	6.54e-03	-0.287000	3.24e-02
CaM pathway	26	1.15e-02	-0.286000	4.87e-02
Calmodulin induced events	26	1.15e-02	-0.286000	4.87e-02
CTLA4 inhibitory signaling	16	4.77e-02	-0.286000	1.23e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	5.64e-02	-0.285000	1.39e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	4.90e-02	-0.284000	1.26e-01
Processive synthesis on the C-strand of the telomere	19	3.20e-02	-0.284000	9.64e-02
Viral Messenger RNA Synthesis	42	1.49e-03	-0.283000	1.22e-02
Formation of the Early Elongation Complex	29	8.33e-03	-0.283000	3.77e-02
Formation of the HIV-1 Early Elongation Complex	29	8.33e-03	-0.283000	3.77e-02
Transport of the SLBP Dependant Mature mRNA	35	3.76e-03	-0.283000	2.29e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	15	5.83e-02	0.282000	1.43e-01
RAF activation	32	5.76e-03	-0.282000	2.97e-02
FOXO-mediated transcription of cell cycle genes	15	5.90e-02	-0.282000	1.45e-01
Nucleobase biosynthesis	15	5.92e-02	-0.281000	1.45e-01
Signaling by high-kinase activity BRAF mutants	27	1.15e-02	-0.281000	4.87e-02
Activation of GABAB receptors	22	2.26e-02	-0.281000	7.55e-02
GABA B receptor activation	22	2.26e-02	-0.281000	7.55e-02
FCGR3A-mediated phagocytosis	48	7.62e-04	-0.281000	7.39e-03
Leishmania phagocytosis	48	7.62e-04	-0.281000	7.39e-03
Parasite infection	48	7.62e-04	-0.281000	7.39e-03
Glucose metabolism	76	2.34e-05	-0.281000	4.62e-04
Formation of the beta-catenin:TCF transactivating complex	31	6.94e-03	-0.280000	3.33e-02
Signaling by FGFR3	32	6.17e-03	-0.280000	3.15e-02
VEGFR2 mediated vascular permeability	23	2.04e-02	-0.279000	7.10e-02
SUMOylation of DNA replication proteins	45	1.19e-03	-0.279000	1.03e-02
Ras activation upon Ca2+ influx through NMDA receptor	13	8.17e-02	-0.279000	1.77e-01
Purine ribonucleoside monophosphate biosynthesis	12	9.48e-02	-0.279000	1.95e-01
DCC mediated attractive signaling	13	8.22e-02	-0.278000	1.78e-01
Cell death signalling via NRAGE, NRIF and NADE	63	1.38e-04	-0.278000	2.21e-03
Diseases associated with glycosylation precursor biosynthesis	17	4.76e-02	-0.278000	1.23e-01
GRB2 events in ERBB2 signaling	11	1.12e-01	-0.277000	2.23e-01
TP53 Regulates Transcription of DNA Repair Genes	53	4.97e-04	-0.277000	5.77e-03
HIV Life Cycle	135	3.04e-08	-0.276000	1.32e-06
rRNA processing in the nucleus and cytosol	185	9.62e-11	0.276000	5.95e-09
N-glycan antennae elongation in the medial/trans-Golgi	22	2.51e-02	0.276000	8.07e-02
RHO GTPases activate PAKs	19	3.87e-02	-0.274000	1.08e-01
Nitric oxide stimulates guanylate cyclase	13	8.77e-02	0.274000	1.84e-01
Nuclear import of Rev protein	33	6.55e-03	-0.274000	3.24e-02
Surfactant metabolism	10	1.34e-01	-0.273000	2.56e-01
Assembly Of The HIV Virion	16	5.86e-02	-0.273000	1.44e-01
RHOBTB3 ATPase cycle	10	1.36e-01	-0.273000	2.57e-01
Budding and maturation of HIV virion	28	1.27e-02	-0.272000	5.23e-02
Gene Silencing by RNA	65	1.51e-04	-0.272000	2.30e-03
Rev-mediated nuclear export of HIV RNA	34	6.27e-03	-0.271000	3.17e-02
NRAGE signals death through JNK	47	1.33e-03	-0.271000	1.11e-02
Transport of the SLBP independent Mature mRNA	34	6.34e-03	-0.271000	3.20e-02
The citric acid (TCA) cycle and respiratory electron transport	147	1.56e-08	-0.270000	6.98e-07
Transport of Mature mRNAs Derived from Intronless Transcripts	42	2.44e-03	-0.270000	1.70e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	1.97e-02	-0.270000	6.93e-02
SHC1 events in ERBB2 signaling	16	6.23e-02	-0.269000	1.47e-01
SUMOylation of intracellular receptors	27	1.58e-02	-0.268000	5.84e-02
Rho GTPase cycle	128	1.76e-07	-0.268000	6.74e-06
Estrogen-dependent gene expression	86	1.83e-05	-0.267000	3.71e-04
NS1 Mediated Effects on Host Pathways	39	3.89e-03	-0.267000	2.32e-02
RMTs methylate histone arginines	29	1.29e-02	-0.267000	5.27e-02
Ca-dependent events	28	1.47e-02	-0.266000	5.60e-02
Gap junction trafficking and regulation	16	6.51e-02	-0.266000	1.51e-01
BBSome-mediated cargo-targeting to cilium	21	3.53e-02	0.265000	1.02e-01
Telomere C-strand (Lagging Strand) Synthesis	32	9.40e-03	-0.265000	4.20e-02
Trafficking of GluR2-containing AMPA receptors	12	1.12e-01	0.265000	2.23e-01
Pyruvate metabolism	26	1.95e-02	-0.265000	6.92e-02
RORA activates gene expression	18	5.20e-02	-0.265000	1.31e-01
Chaperonin-mediated protein folding	69	1.47e-04	-0.264000	2.30e-03
GAB1 signalosome	14	8.69e-02	-0.264000	1.83e-01
Removal of the Flap Intermediate from the C-strand	17	5.95e-02	-0.264000	1.45e-01
Insulin receptor recycling	19	4.65e-02	-0.264000	1.21e-01
Transcription of E2F targets under negative control by DREAM complex	19	4.65e-02	-0.264000	1.21e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	30	1.25e-02	-0.264000	5.21e-02
Signaling by BRAF and RAF fusions	53	9.24e-04	-0.263000	8.60e-03
Formation of apoptosome	11	1.31e-01	-0.263000	2.50e-01
Regulation of the apoptosome activity	11	1.31e-01	-0.263000	2.50e-01
The phototransduction cascade	17	6.09e-02	-0.263000	1.47e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	4.22e-02	-0.262000	1.14e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	103	4.32e-06	-0.262000	1.06e-04
ERK/MAPK targets	22	3.36e-02	-0.262000	9.85e-02
Late Phase of HIV Life Cycle	124	5.01e-07	-0.262000	1.76e-05
G0 and Early G1	27	1.87e-02	-0.261000	6.68e-02
Nucleotide salvage	20	4.30e-02	-0.261000	1.15e-01
Cristae formation	13	1.03e-01	-0.261000	2.07e-01
SUMOylation of RNA binding proteins	44	2.74e-03	-0.261000	1.79e-02
G1/S-Specific Transcription	29	1.54e-02	-0.260000	5.79e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	11	1.36e-01	-0.260000	2.57e-01
Adrenaline,noradrenaline inhibits insulin secretion	18	5.65e-02	-0.260000	1.39e-01
Transport of Mature mRNA Derived from an Intronless Transcript	41	4.03e-03	-0.260000	2.38e-02
Mitotic Telophase/Cytokinesis	13	1.05e-01	-0.260000	2.11e-01
FGFR2 mutant receptor activation	20	4.44e-02	-0.260000	1.17e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	1.56e-02	-0.260000	5.80e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	1.56e-02	-0.260000	5.80e-02
Respiratory electron transport	98	9.09e-06	-0.260000	1.97e-04
Influenza Infection	148	5.77e-08	0.259000	2.34e-06
Diseases of programmed cell death	25	2.56e-02	-0.258000	8.19e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	1.04e-02	-0.258000	4.53e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	21	4.14e-02	-0.257000	1.13e-01
Export of Viral Ribonucleoproteins from Nucleus	31	1.32e-02	-0.257000	5.31e-02
NEP/NS2 Interacts with the Cellular Export Machinery	31	1.32e-02	-0.257000	5.31e-02
Processing and activation of SUMO	10	1.59e-01	-0.257000	2.83e-01
Chromatin modifying enzymes	191	1.06e-09	-0.256000	5.52e-08
Chromatin organization	191	1.06e-09	-0.256000	5.52e-08
Fcgamma receptor (FCGR) dependent phagocytosis	71	1.92e-04	-0.256000	2.77e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	30	1.53e-02	-0.256000	5.77e-02
Oncogenic MAPK signaling	69	2.49e-04	-0.255000	3.28e-03
Apoptotic factor-mediated response	16	7.74e-02	-0.255000	1.70e-01
Glucagon signaling in metabolic regulation	21	4.36e-02	-0.254000	1.16e-01
SHC-mediated cascade:FGFR1	11	1.46e-01	-0.253000	2.68e-01
Inwardly rectifying K+ channels	16	8.02e-02	-0.253000	1.75e-01
SUMOylation of chromatin organization proteins	54	1.34e-03	-0.252000	1.11e-02
Post NMDA receptor activation events	48	2.53e-03	-0.252000	1.75e-02
Polymerase switching on the C-strand of the telomere	24	3.29e-02	-0.252000	9.74e-02
mRNA Capping	26	2.66e-02	-0.251000	8.38e-02
Signaling by FGFR2 IIIa TM	18	6.52e-02	-0.251000	1.51e-01
Signaling by RAF1 mutants	31	1.56e-02	-0.251000	5.80e-02
Protein folding	75	1.76e-04	-0.251000	2.67e-03
Cytochrome c-mediated apoptotic response	13	1.18e-01	-0.251000	2.30e-01
HDMs demethylate histones	21	4.79e-02	-0.249000	1.23e-01
DAG and IP3 signaling	32	1.47e-02	-0.249000	5.60e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	34	1.26e-02	-0.247000	5.21e-02
The NLRP3 inflammasome	12	1.41e-01	0.246000	2.60e-01
p75 NTR receptor-mediated signalling	80	1.49e-04	-0.245000	2.30e-03
MECP2 regulates neuronal receptors and channels	16	8.95e-02	-0.245000	1.87e-01
RHO GTPases Activate ROCKs	17	8.09e-02	-0.245000	1.76e-01
Vasopressin regulates renal water homeostasis via Aquaporins	26	3.22e-02	-0.243000	9.65e-02
RNA Pol II CTD phosphorylation and interaction with CE	24	4.02e-02	-0.242000	1.11e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	24	4.02e-02	-0.242000	1.11e-01
Interleukin-6 family signaling	20	6.33e-02	0.240000	1.49e-01
Signaling by FGFR	67	6.91e-04	-0.240000	7.13e-03
Epigenetic regulation of gene expression	79	2.38e-04	-0.239000	3.22e-03
Signaling by ERBB2	41	8.35e-03	-0.238000	3.77e-02
IKK complex recruitment mediated by RIP1	21	5.93e-02	-0.238000	1.45e-01
Signaling by EGFR	45	5.84e-03	-0.238000	2.99e-02
Signal amplification	22	5.45e-02	-0.237000	1.35e-01
Striated Muscle Contraction	10	1.97e-01	-0.236000	3.32e-01
Platelet degranulation	81	2.48e-04	-0.236000	3.28e-03
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	2.78e-03	-0.235000	1.79e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	2.78e-03	-0.235000	1.79e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	2.78e-03	-0.235000	1.79e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	2.78e-03	-0.235000	1.79e-02
Signaling by NOTCH1 in Cancer	54	2.78e-03	-0.235000	1.79e-02
Post-translational protein phosphorylation	68	8.04e-04	0.235000	7.69e-03
Nicotinamide salvaging	14	1.28e-01	0.235000	2.48e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	4.21e-02	-0.235000	1.14e-01
Recycling pathway of L1	28	3.17e-02	-0.235000	9.61e-02
Signaling by ROBO receptors	200	1.15e-08	0.234000	5.35e-07
Detoxification of Reactive Oxygen Species	28	3.19e-02	-0.234000	9.62e-02
HIV Infection	204	8.66e-09	-0.234000	4.17e-07
Endosomal Sorting Complex Required For Transport (ESCRT)	31	2.43e-02	-0.234000	7.88e-02
Gap junction trafficking	14	1.30e-01	-0.233000	2.50e-01
Regulation of TP53 Activity through Association with Co-factors	10	2.02e-01	-0.233000	3.38e-01
SUMOylation of DNA damage response and repair proteins	71	7.19e-04	-0.232000	7.36e-03
PI Metabolism	67	1.04e-03	-0.232000	9.26e-03
SHC1 events in ERBB4 signaling	10	2.06e-01	-0.231000	3.42e-01
Transcriptional Regulation by MECP2	50	4.72e-03	-0.231000	2.60e-02
Transcription of the HIV genome	59	2.22e-03	-0.230000	1.62e-02
Beta-catenin phosphorylation cascade	17	1.01e-01	-0.230000	2.04e-01
Ca2+ pathway	46	6.96e-03	-0.230000	3.33e-02
EPHA-mediated growth cone collapse	13	1.51e-01	-0.230000	2.75e-01
MAP2K and MAPK activation	31	2.68e-02	-0.230000	8.42e-02
Regulation of RUNX1 Expression and Activity	17	1.02e-01	-0.229000	2.06e-01
Formation of RNA Pol II elongation complex	50	5.07e-03	-0.229000	2.70e-02
RNA Polymerase II Transcription Elongation	50	5.07e-03	-0.229000	2.70e-02
HSF1-dependent transactivation	27	3.96e-02	-0.229000	1.11e-01
TGF-beta receptor signaling activates SMADs	32	2.53e-02	-0.229000	8.12e-02
Diseases of DNA repair	12	1.71e-01	-0.228000	3.01e-01
Biotin transport and metabolism	11	1.91e-01	-0.228000	3.27e-01
GABA receptor activation	27	4.04e-02	-0.228000	1.11e-01
Collagen degradation	28	3.70e-02	0.228000	1.05e-01
Leading Strand Synthesis	14	1.41e-01	-0.227000	2.60e-01
Polymerase switching	14	1.41e-01	-0.227000	2.60e-01
Inactivation, recovery and regulation of the phototransduction cascade	16	1.16e-01	-0.227000	2.28e-01
ESR-mediated signaling	140	3.56e-06	-0.227000	9.26e-05
Lagging Strand Synthesis	20	7.90e-02	-0.227000	1.73e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	9.57e-02	-0.227000	1.96e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	4.16e-02	-0.227000	1.13e-01
E2F mediated regulation of DNA replication	21	7.27e-02	-0.226000	1.63e-01
FRS-mediated FGFR4 signaling	11	1.95e-01	-0.226000	3.32e-01
Disorders of Developmental Biology	13	1.59e-01	-0.226000	2.83e-01
Disorders of Nervous System Development	13	1.59e-01	-0.226000	2.83e-01
Loss of function of MECP2 in Rett syndrome	13	1.59e-01	-0.226000	2.83e-01
Pervasive developmental disorders	13	1.59e-01	-0.226000	2.83e-01
Aquaporin-mediated transport	27	4.26e-02	-0.226000	1.15e-01
Downstream signaling of activated FGFR1	20	8.11e-02	-0.225000	1.76e-01
Response to elevated platelet cytosolic Ca2+	85	3.52e-04	-0.224000	4.44e-03
Mitochondrial calcium ion transport	21	7.54e-02	-0.224000	1.67e-01
ZBP1(DAI) mediated induction of type I IFNs	18	1.00e-01	0.224000	2.04e-01
Signaling by Rho GTPases	334	2.49e-12	-0.223000	1.70e-10
CDC6 association with the ORC:origin complex	11	2.00e-01	-0.223000	3.36e-01
RET signaling	33	2.74e-02	-0.222000	8.57e-02
Signaling by ERBB2 ECD mutants	14	1.51e-01	-0.222000	2.75e-01
Platelet activation, signaling and aggregation	172	5.32e-07	-0.222000	1.82e-05
Hyaluronan metabolism	13	1.66e-01	-0.222000	2.94e-01
Plasma lipoprotein remodeling	13	1.69e-01	0.221000	2.98e-01
Protein ubiquitination	62	2.75e-03	-0.220000	1.79e-02
Apoptotic cleavage of cellular proteins	32	3.13e-02	-0.220000	9.53e-02
PLC beta mediated events	39	1.77e-02	-0.220000	6.45e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	26	5.37e-02	-0.219000	1.34e-01
Signaling by FGFR3 in disease	14	1.57e-01	-0.219000	2.82e-01
Signaling by FGFR3 point mutants in cancer	14	1.57e-01	-0.219000	2.82e-01
Transcriptional regulation of white adipocyte differentiation	73	1.25e-03	-0.219000	1.06e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	31	3.55e-02	0.218000	1.02e-01
Plasma lipoprotein assembly	10	2.32e-01	0.218000	3.73e-01
Response of Mtb to phagocytosis	20	9.17e-02	-0.218000	1.89e-01
Synthesis of IP3 and IP4 in the cytosol	18	1.10e-01	-0.218000	2.19e-01
COPI-mediated anterograde transport	76	1.04e-03	-0.218000	9.26e-03
HATs acetylate histones	77	9.68e-04	-0.218000	8.89e-03
Signaling by FGFR2 in disease	29	4.28e-02	-0.217000	1.15e-01
Peptide ligand-binding receptors	53	6.22e-03	0.217000	3.16e-02
Polo-like kinase mediated events	16	1.32e-01	-0.217000	2.53e-01
mRNA decay by 5’ to 3’ exoribonuclease	14	1.59e-01	-0.217000	2.83e-01
Telomere Maintenance	62	3.11e-03	-0.217000	1.94e-02
DARPP-32 events	23	7.22e-02	-0.217000	1.63e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	75	1.21e-03	0.216000	1.04e-02
DNA strand elongation	32	3.47e-02	-0.216000	1.01e-01
MAPK targets/ Nuclear events mediated by MAP kinases	30	4.12e-02	-0.215000	1.13e-01
Downregulation of ERBB2:ERBB3 signaling	11	2.17e-01	-0.215000	3.57e-01
Molecules associated with elastic fibres	25	6.32e-02	0.215000	1.49e-01
STING mediated induction of host immune responses	10	2.40e-01	0.214000	3.81e-01
RHO GTPase Effectors	217	5.69e-08	-0.214000	2.34e-06
Regulation of innate immune responses to cytosolic DNA	11	2.20e-01	0.214000	3.58e-01
Cleavage of the damaged pyrimidine	16	1.39e-01	-0.214000	2.60e-01
Depyrimidination	16	1.39e-01	-0.214000	2.60e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	1.39e-01	-0.214000	2.60e-01
Semaphorin interactions	53	7.23e-03	-0.213000	3.42e-02
HCMV Early Events	58	4.99e-03	-0.213000	2.68e-02
Transcriptional Regulation by E2F6	31	4.02e-02	-0.213000	1.11e-01
Opioid Signalling	66	2.80e-03	-0.213000	1.79e-02
Downstream signaling of activated FGFR3	17	1.30e-01	-0.212000	2.50e-01
Glycolysis	61	4.25e-03	-0.212000	2.44e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	25	6.70e-02	-0.212000	1.54e-01
SUMO E3 ligases SUMOylate target proteins	155	5.56e-06	-0.212000	1.34e-04
Amyloid fiber formation	35	3.12e-02	-0.211000	9.52e-02
EPH-Ephrin signaling	83	9.26e-04	-0.210000	8.60e-03
Signaling by NOTCH1	68	2.72e-03	-0.210000	1.79e-02
Signaling by FGFR2	56	6.57e-03	-0.210000	3.24e-02
ECM proteoglycans	40	2.18e-02	0.210000	7.45e-02
COPI-dependent Golgi-to-ER retrograde traffic	74	1.87e-03	-0.209000	1.43e-02
Activation of HOX genes during differentiation	55	7.32e-03	-0.209000	3.43e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	55	7.32e-03	-0.209000	3.43e-02
NoRC negatively regulates rRNA expression	41	2.06e-02	-0.209000	7.13e-02
The activation of arylsulfatases	10	2.54e-01	0.208000	3.97e-01
Initiation of Nuclear Envelope (NE) Reformation	19	1.17e-01	-0.208000	2.30e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	29	5.27e-02	-0.208000	1.32e-01
FRS-mediated FGFR1 signaling	13	1.95e-01	-0.207000	3.32e-01
Complement cascade	14	1.79e-01	0.207000	3.12e-01
Regulation of Complement cascade	14	1.79e-01	0.207000	3.12e-01
Oncogene Induced Senescence	32	4.26e-02	-0.207000	1.15e-01
EPH-ephrin mediated repulsion of cells	44	1.75e-02	-0.207000	6.44e-02
Negative epigenetic regulation of rRNA expression	44	1.77e-02	-0.207000	6.45e-02
Signaling by KIT in disease	17	1.40e-01	0.207000	2.60e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	17	1.40e-01	0.207000	2.60e-01
Host Interactions of HIV factors	114	1.41e-04	-0.207000	2.23e-03
Signaling by Insulin receptor	53	9.50e-03	-0.206000	4.21e-02
Glutamate and glutamine metabolism	12	2.19e-01	-0.205000	3.58e-01
Factors involved in megakaryocyte development and platelet production	106	2.77e-04	-0.205000	3.56e-03
SUMOylation	161	7.72e-06	-0.205000	1.70e-04
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	2.20e-01	-0.204000	3.58e-01
NCAM1 interactions	27	6.64e-02	0.204000	1.53e-01
Diseases associated with glycosaminoglycan metabolism	32	4.58e-02	0.204000	1.20e-01
APC-Cdc20 mediated degradation of Nek2A	26	7.21e-02	-0.204000	1.63e-01
Nuclear Pore Complex (NPC) Disassembly	35	3.74e-02	-0.203000	1.05e-01
FGFR2 alternative splicing	24	8.47e-02	-0.203000	1.80e-01
Chondroitin sulfate biosynthesis	16	1.61e-01	0.202000	2.86e-01
FOXO-mediated transcription	51	1.25e-02	-0.202000	5.21e-02
Lysosome Vesicle Biogenesis	33	4.55e-02	-0.201000	1.20e-01
Negative regulation of MAPK pathway	40	2.81e-02	-0.201000	8.76e-02
Metabolism of non-coding RNA	51	1.33e-02	-0.201000	5.31e-02
snRNP Assembly	51	1.33e-02	-0.201000	5.31e-02
Long-term potentiation	14	1.97e-01	-0.199000	3.32e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	1.69e-01	-0.199000	2.98e-01
LDL clearance	15	1.84e-01	-0.198000	3.18e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	14	2.00e-01	-0.198000	3.36e-01
Unwinding of DNA	12	2.38e-01	-0.197000	3.79e-01
Signaling by ERBB2 KD Mutants	19	1.38e-01	-0.197000	2.59e-01
Signaling by NODAL	11	2.59e-01	-0.197000	4.02e-01
Synthesis of PIPs at the plasma membrane	43	2.58e-02	-0.197000	8.20e-02
Branched-chain amino acid catabolism	20	1.28e-01	-0.196000	2.48e-01
STAT5 activation downstream of FLT3 ITD mutants	10	2.82e-01	-0.196000	4.27e-01
Cyclin D associated events in G1	41	3.02e-02	-0.196000	9.28e-02
G1 Phase	41	3.02e-02	-0.196000	9.28e-02
PI3K/AKT Signaling in Cancer	71	4.39e-03	-0.196000	2.48e-02
Recognition of DNA damage by PCNA-containing replication complex	30	6.43e-02	-0.195000	1.50e-01
Receptor Mediated Mitophagy	10	2.85e-01	-0.195000	4.29e-01
MHC class II antigen presentation	82	2.28e-03	-0.195000	1.65e-02
rRNA processing	211	1.09e-06	0.195000	3.44e-05
Base-Excision Repair, AP Site Formation	18	1.52e-01	-0.195000	2.75e-01
Regulation of lipid metabolism by PPARalpha	106	5.37e-04	-0.195000	6.04e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	12	2.44e-01	-0.194000	3.86e-01
Golgi-to-ER retrograde transport	107	5.39e-04	-0.194000	6.04e-03
Transport of vitamins, nucleosides, and related molecules	29	7.10e-02	-0.194000	1.61e-01
Signaling by ERBB2 in Cancer	20	1.34e-01	-0.193000	2.56e-01
Infection with Mycobacterium tuberculosis	21	1.25e-01	-0.193000	2.43e-01
PKA activation in glucagon signalling	12	2.47e-01	-0.193000	3.88e-01
Downregulation of ERBB2 signaling	23	1.09e-01	-0.193000	2.18e-01
Presynaptic phase of homologous DNA pairing and strand exchange	38	3.97e-02	-0.193000	1.11e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.82e-01	-0.193000	3.16e-01
HCMV Infection	82	2.58e-03	-0.193000	1.77e-02
Chromosome Maintenance	88	1.86e-03	-0.192000	1.43e-02
Signaling by FGFR in disease	48	2.15e-02	-0.192000	7.39e-02
Mitotic Prophase	81	2.88e-03	-0.192000	1.84e-02
G-protein mediated events	40	3.61e-02	-0.192000	1.03e-01
S Phase	153	4.44e-05	-0.191000	8.02e-04
RNA Polymerase II Pre-transcription Events	70	5.80e-03	-0.191000	2.98e-02
Acyl chain remodelling of PS	10	2.96e-01	0.191000	4.43e-01
Constitutive Signaling by EGFRvIII	13	2.34e-01	-0.191000	3.75e-01
Signaling by EGFRvIII in Cancer	13	2.34e-01	-0.191000	3.75e-01
Membrane binding and targetting of GAG proteins	14	2.18e-01	-0.190000	3.57e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	2.18e-01	-0.190000	3.57e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	1.15e-01	0.190000	2.27e-01
Diseases of signal transduction by growth factor receptors and second messengers	330	3.58e-09	-0.189000	1.79e-07
Translation of Replicase and Assembly of the Replication Transcription Complex	13	2.37e-01	-0.189000	3.79e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	28	8.31e-02	-0.189000	1.78e-01
Nuclear Envelope Breakdown	51	1.97e-02	-0.189000	6.93e-02
Extra-nuclear estrogen signaling	57	1.38e-02	-0.189000	5.45e-02
RHO GTPases Activate Formins	115	4.80e-04	-0.189000	5.73e-03
Sphingolipid de novo biosynthesis	38	4.43e-02	-0.189000	1.17e-01
PERK regulates gene expression	31	6.93e-02	0.189000	1.59e-01
Purine salvage	12	2.60e-01	-0.188000	4.03e-01
Chondroitin sulfate/dermatan sulfate metabolism	43	3.36e-02	0.187000	9.85e-02
Signaling by WNT	224	1.51e-06	-0.187000	4.55e-05
Costimulation by the CD28 family	40	4.15e-02	-0.186000	1.13e-01
PPARA activates gene expression	104	1.07e-03	-0.186000	9.48e-03
Phosphorylation of the APC/C	20	1.51e-01	-0.186000	2.75e-01
Clathrin-mediated endocytosis	125	3.43e-04	-0.186000	4.38e-03
G2/M DNA damage checkpoint	57	1.58e-02	-0.185000	5.84e-02
activated TAK1 mediates p38 MAPK activation	18	1.75e-01	-0.185000	3.06e-01
cGMP effects	10	3.14e-01	0.184000	4.62e-01
Defective B4GALT7 causes EDS, progeroid type	16	2.03e-01	0.184000	3.40e-01
NR1H2 and NR1H3-mediated signaling	34	6.40e-02	-0.184000	1.50e-01
p130Cas linkage to MAPK signaling for integrins	11	2.93e-01	-0.183000	4.39e-01
Nucleotide Excision Repair	106	1.14e-03	-0.183000	1.00e-02
Mitotic Metaphase and Anaphase	216	3.88e-06	-0.183000	9.90e-05
HSF1 activation	21	1.48e-01	-0.183000	2.70e-01
Mitotic Anaphase	215	4.20e-06	-0.182000	1.05e-04
Activation of the pre-replicative complex	33	7.00e-02	-0.182000	1.59e-01
Vitamin D (calciferol) metabolism	10	3.19e-01	-0.182000	4.67e-01
Smooth Muscle Contraction	29	9.06e-02	-0.182000	1.89e-01
Regulation of FZD by ubiquitination	17	1.95e-01	0.181000	3.32e-01
Integrin signaling	22	1.41e-01	-0.181000	2.61e-01
Platelet Aggregation (Plug Formation)	22	1.41e-01	-0.181000	2.61e-01
Insulin receptor signalling cascade	35	6.40e-02	-0.181000	1.50e-01
Formation of Incision Complex in GG-NER	41	4.55e-02	-0.181000	1.20e-01
Phospholipid metabolism	155	1.07e-04	-0.180000	1.81e-03
Meiotic synapsis	26	1.12e-01	-0.180000	2.23e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	2.13e-01	-0.180000	3.52e-01
SHC-mediated cascade:FGFR2	10	3.26e-01	-0.179000	4.71e-01
Resolution of D-Loop Structures	31	8.51e-02	-0.179000	1.81e-01
Homologous DNA Pairing and Strand Exchange	41	4.79e-02	-0.179000	1.23e-01
Signaling by TGFB family members	91	3.33e-03	-0.178000	2.06e-02
HDACs deacetylate histones	30	9.14e-02	-0.178000	1.89e-01
Meiosis	47	3.49e-02	-0.178000	1.01e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	2.18e-01	0.178000	3.57e-01
TBC/RABGAPs	42	4.67e-02	-0.177000	1.21e-01
Regulation of IFNG signaling	11	3.09e-01	0.177000	4.58e-01
Attenuation phase	19	1.81e-01	-0.177000	3.16e-01
Carboxyterminal post-translational modifications of tubulin	26	1.18e-01	-0.177000	2.30e-01
Cellular Senescence	123	7.26e-04	-0.177000	7.37e-03
Apoptotic execution phase	40	5.35e-02	-0.177000	1.34e-01
Deadenylation of mRNA	22	1.52e-01	-0.177000	2.75e-01
Signaling by Nuclear Receptors	191	3.00e-05	-0.175000	5.50e-04
Meiotic recombination	23	1.46e-01	-0.175000	2.68e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	30	9.73e-02	-0.175000	1.98e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	3.17e-01	-0.174000	4.66e-01
FOXO-mediated transcription of cell death genes	15	2.43e-01	-0.174000	3.85e-01
Regulated proteolysis of p75NTR	10	3.42e-01	-0.173000	4.89e-01
RIP-mediated NFkB activation via ZBP1	15	2.47e-01	0.173000	3.88e-01
Transcriptional Regulation by VENTX	36	7.33e-02	-0.173000	1.64e-01
Cellular response to heat stress	87	5.50e-03	-0.172000	2.86e-02
RHO GTPases activate CIT	17	2.19e-01	-0.172000	3.58e-01
Downregulation of TGF-beta receptor signaling	26	1.29e-01	-0.172000	2.48e-01
Signaling by MET	60	2.13e-02	-0.172000	7.36e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	2.83e-01	-0.172000	4.27e-01
Insulin processing	22	1.64e-01	-0.171000	2.91e-01
O-glycosylation of TSR domain-containing proteins	30	1.05e-01	0.171000	2.11e-01
Metalloprotease DUBs	20	1.87e-01	-0.171000	3.21e-01
GPVI-mediated activation cascade	21	1.77e-01	-0.170000	3.10e-01
Class A/1 (Rhodopsin-like receptors)	97	3.84e-03	0.170000	2.32e-02
PIWI-interacting RNA (piRNA) biogenesis	17	2.26e-01	-0.170000	3.65e-01
Extension of Telomeres	49	4.06e-02	-0.169000	1.12e-01
Purine catabolism	15	2.57e-01	-0.169000	4.00e-01
FCGR3A-mediated IL10 synthesis	26	1.36e-01	-0.169000	2.58e-01
HIV Transcription Initiation	41	6.17e-02	-0.169000	1.47e-01
RNA Polymerase II HIV Promoter Escape	41	6.17e-02	-0.169000	1.47e-01
RNA Polymerase II Promoter Escape	41	6.17e-02	-0.169000	1.47e-01
RNA Polymerase II Transcription Initiation	41	6.17e-02	-0.169000	1.47e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	41	6.17e-02	-0.169000	1.47e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	41	6.17e-02	-0.169000	1.47e-01
Regulation of PTEN gene transcription	57	2.78e-02	-0.169000	8.69e-02
Transport of inorganic cations/anions and amino acids/oligopeptides	60	2.44e-02	-0.168000	7.88e-02
Circadian Clock	65	1.93e-02	-0.168000	6.85e-02
Interferon gamma signaling	54	3.31e-02	0.168000	9.79e-02
PKA-mediated phosphorylation of CREB	15	2.61e-01	-0.168000	4.04e-01
HCMV Late Events	55	3.16e-02	-0.168000	9.60e-02
Acyl chain remodelling of PE	12	3.15e-01	0.168000	4.63e-01
Metabolism of nucleotides	88	6.77e-03	-0.167000	3.27e-02
Constitutive Signaling by Aberrant PI3K in Cancer	46	5.01e-02	-0.167000	1.28e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	61	2.42e-02	-0.167000	7.87e-02
RNA Polymerase III Transcription Initiation	34	9.21e-02	-0.167000	1.89e-01
MAPK6/MAPK4 signaling	80	1.01e-02	-0.166000	4.42e-02
Deadenylation-dependent mRNA decay	51	3.98e-02	-0.166000	1.11e-01
ADP signalling through P2Y purinoceptor 1	17	2.35e-01	-0.166000	3.76e-01
Carnitine metabolism	10	3.63e-01	0.166000	5.10e-01
VEGFA-VEGFR2 Pathway	82	9.45e-03	-0.166000	4.21e-02
Synthesis of IP2, IP, and Ins in the cytosol	12	3.20e-01	-0.166000	4.68e-01
Acyl chain remodelling of PC	13	3.02e-01	0.165000	4.49e-01
Translation	269	3.33e-06	0.165000	9.03e-05
RHO GTPases Activate NADPH Oxidases	16	2.54e-01	-0.165000	3.97e-01
Negative regulation of FLT3	13	3.06e-01	-0.164000	4.55e-01
Regulation of TP53 Activity through Acetylation	27	1.41e-01	-0.164000	2.60e-01
Signal transduction by L1	20	2.05e-01	-0.164000	3.42e-01
Processing of DNA double-strand break ends	62	2.59e-02	-0.164000	8.20e-02
Resolution of Abasic Sites (AP sites)	37	8.53e-02	-0.164000	1.81e-01
Transcriptional activation of mitochondrial biogenesis	52	4.15e-02	-0.163000	1.13e-01
Caspase-mediated cleavage of cytoskeletal proteins	11	3.48e-01	-0.163000	4.97e-01
Global Genome Nucleotide Excision Repair (GG-NER)	81	1.11e-02	-0.163000	4.79e-02
Transcriptional Regulation by TP53	328	4.60e-07	-0.162000	1.71e-05
Oxidative Stress Induced Senescence	61	2.84e-02	-0.162000	8.83e-02
Regulation of HSF1-mediated heat shock response	71	1.81e-02	-0.162000	6.53e-02
Signaling by NOTCH2	28	1.38e-01	-0.162000	2.59e-01
Signaling by FGFR4 in disease	10	3.75e-01	-0.162000	5.21e-01
RAF-independent MAPK1/3 activation	22	1.89e-01	0.162000	3.24e-01
Uptake and actions of bacterial toxins	24	1.71e-01	-0.162000	3.01e-01
Death Receptor Signalling	119	2.39e-03	-0.161000	1.69e-02
Hemostasis	384	6.45e-08	-0.161000	2.54e-06
Role of LAT2/NTAL/LAB on calcium mobilization	12	3.35e-01	-0.161000	4.82e-01
DNA Replication	122	2.30e-03	-0.160000	1.65e-02
MAP kinase activation	61	3.11e-02	-0.160000	9.51e-02
Downstream signaling of activated FGFR4	16	2.71e-01	-0.159000	4.17e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.78e-01	-0.159000	3.11e-01
MyD88-independent TLR4 cascade	88	1.00e-02	-0.159000	4.41e-02
TRIF(TICAM1)-mediated TLR4 signaling	88	1.00e-02	-0.159000	4.41e-02
Positive epigenetic regulation of rRNA expression	41	7.95e-02	-0.158000	1.73e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	29	1.41e-01	0.158000	2.60e-01
COPI-independent Golgi-to-ER retrograde traffic	33	1.17e-01	-0.158000	2.30e-01
Signaling by BMP	20	2.24e-01	0.157000	3.63e-01
Norepinephrine Neurotransmitter Release Cycle	11	3.67e-01	-0.157000	5.15e-01
Processing of SMDT1	14	3.09e-01	-0.157000	4.58e-01
VxPx cargo-targeting to cilium	16	2.78e-01	-0.157000	4.23e-01
MAPK family signaling cascades	245	2.58e-05	-0.156000	4.93e-04
RNA Polymerase III Abortive And Retractive Initiation	39	9.19e-02	-0.156000	1.89e-01
RNA Polymerase III Transcription	39	9.19e-02	-0.156000	1.89e-01
Other semaphorin interactions	12	3.50e-01	0.156000	4.98e-01
PKA activation	13	3.31e-01	-0.156000	4.76e-01
Synthesis of DNA	114	4.30e-03	-0.155000	2.45e-02
Transport of Mature Transcript to Cytoplasm	78	1.81e-02	-0.155000	6.53e-02
Signaling by PDGFRA extracellular domain mutants	10	3.97e-01	0.155000	5.41e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	10	3.97e-01	0.155000	5.41e-01
PI-3K cascade:FGFR3	11	3.74e-01	-0.155000	5.21e-01
Aggrephagy	21	2.20e-01	-0.155000	3.58e-01
Rap1 signalling	14	3.18e-01	-0.154000	4.67e-01
Retinoid metabolism and transport	26	1.75e-01	0.154000	3.06e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	28	1.59e-01	-0.154000	2.83e-01
Cell Cycle	578	3.50e-10	-0.153000	2.07e-08
TCF dependent signaling in response to WNT	150	1.21e-03	-0.153000	1.04e-02
Heparan sulfate/heparin (HS-GAG) metabolism	43	8.31e-02	0.153000	1.78e-01
Tight junction interactions	14	3.23e-01	0.153000	4.70e-01
Rab regulation of trafficking	114	4.98e-03	-0.152000	2.68e-02
Base Excision Repair	45	7.73e-02	-0.152000	1.70e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	2.92e-01	-0.152000	4.39e-01
Signaling by VEGF	90	1.31e-02	-0.151000	5.31e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	3.12e-01	-0.151000	4.60e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	47	7.36e-02	-0.151000	1.64e-01
HDR through Single Strand Annealing (SSA)	36	1.18e-01	-0.151000	2.30e-01
FLT3 Signaling	31	1.47e-01	-0.151000	2.69e-01
Interleukin-17 signaling	65	3.60e-02	-0.150000	1.03e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	16	3.00e-01	-0.150000	4.48e-01
Bile acid and bile salt metabolism	25	1.97e-01	-0.149000	3.33e-01
A tetrasaccharide linker sequence is required for GAG synthesis	22	2.29e-01	0.148000	3.68e-01
RAB GEFs exchange GTP for GDP on RABs	83	2.05e-02	-0.147000	7.12e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	15	3.24e-01	-0.147000	4.70e-01
NOTCH4 Intracellular Domain Regulates Transcription	18	2.81e-01	-0.147000	4.25e-01
MyD88 dependent cascade initiated on endosome	80	2.35e-02	-0.147000	7.71e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	80	2.35e-02	-0.147000	7.71e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade	80	2.35e-02	-0.147000	7.71e-02
Interleukin-15 signaling	11	4.01e-01	0.146000	5.44e-01
Interleukin-2 family signaling	25	2.07e-01	0.146000	3.44e-01
Prolactin receptor signaling	11	4.04e-01	0.145000	5.47e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	69	3.72e-02	-0.145000	1.05e-01
SUMOylation of immune response proteins	11	4.05e-01	-0.145000	5.48e-01
Signaling by EGFR in Cancer	21	2.51e-01	-0.145000	3.93e-01
Nuclear Events (kinase and transcription factor activation)	56	6.23e-02	-0.144000	1.47e-01
Kinesins	36	1.35e-01	-0.144000	2.56e-01
Activation of NMDA receptors and postsynaptic events	58	5.90e-02	-0.143000	1.45e-01
Effects of PIP2 hydrolysis	22	2.45e-01	-0.143000	3.86e-01
Negative regulation of the PI3K/AKT network	75	3.21e-02	-0.143000	9.65e-02
Glycerophospholipid biosynthesis	89	1.99e-02	-0.143000	6.97e-02
N-Glycan antennae elongation	14	3.56e-01	0.143000	5.03e-01
FRS-mediated FGFR2 signaling	12	3.94e-01	-0.142000	5.39e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	2.72e-01	-0.142000	4.18e-01
Late endosomal microautophagy	29	1.86e-01	-0.142000	3.21e-01
Association of TriC/CCT with target proteins during biosynthesis	35	1.47e-01	-0.142000	2.69e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	3.13e-01	-0.141000	4.61e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	69	4.33e-02	-0.141000	1.16e-01
Beta-catenin independent WNT signaling	120	7.93e-03	-0.140000	3.63e-02
Resolution of Sister Chromatid Cohesion	103	1.39e-02	-0.140000	5.51e-02
Pentose phosphate pathway	14	3.65e-01	-0.140000	5.13e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	3.64e-02	-0.140000	1.03e-01
Mitotic Spindle Checkpoint	107	1.29e-02	-0.139000	5.28e-02
Metal ion SLC transporters	17	3.22e-01	0.139000	4.70e-01
Degradation of beta-catenin by the destruction complex	77	3.57e-02	-0.138000	1.02e-01
Maturation of nucleoprotein	10	4.49e-01	-0.138000	5.93e-01
Reproduction	53	8.24e-02	-0.138000	1.78e-01
mRNA Splicing - Minor Pathway	52	8.62e-02	-0.138000	1.82e-01
Intracellular signaling by second messengers	251	1.81e-04	-0.138000	2.67e-03
Signaling by NOTCH3	41	1.28e-01	-0.137000	2.48e-01
Cell Cycle Checkpoints	242	2.43e-04	-0.137000	3.26e-03
FCERI mediated MAPK activation	23	2.57e-01	-0.137000	4.00e-01
Inflammasomes	15	3.60e-01	0.137000	5.08e-01
Cell Cycle, Mitotic	466	5.01e-07	-0.136000	1.76e-05
CD28 co-stimulation	25	2.38e-01	-0.136000	3.79e-01
G alpha (z) signalling events	31	1.90e-01	-0.136000	3.26e-01
TP53 Regulates Metabolic Genes	80	3.58e-02	-0.136000	1.02e-01
Toll Like Receptor 9 (TLR9) Cascade	84	3.25e-02	-0.135000	9.66e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	3.83e-01	-0.135000	5.26e-01
Deubiquitination	222	5.57e-04	-0.135000	6.19e-03
Cyclin A/B1/B2 associated events during G2/M transition	23	2.64e-01	-0.135000	4.07e-01
DNA Damage Recognition in GG-NER	37	1.57e-01	-0.135000	2.82e-01
Integration of energy metabolism	76	4.27e-02	-0.135000	1.15e-01
Syndecan interactions	19	3.11e-01	-0.134000	4.60e-01
RAF/MAP kinase cascade	203	9.93e-04	-0.134000	8.97e-03
Dual incision in TC-NER	62	7.06e-02	-0.133000	1.60e-01
Apoptosis	148	5.38e-03	-0.133000	2.82e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	21	2.93e-01	-0.133000	4.39e-01
Signaling by NOTCH	158	4.09e-03	-0.133000	2.40e-02
Frs2-mediated activation	12	4.29e-01	-0.132000	5.75e-01
p75NTR signals via NF-kB	15	3.77e-01	0.132000	5.22e-01
ABC transporters in lipid homeostasis	12	4.29e-01	0.132000	5.75e-01
Glycogen synthesis	15	3.77e-01	0.132000	5.22e-01
Amino acids regulate mTORC1	48	1.15e-01	-0.132000	2.27e-01
HDR through Homologous Recombination (HRR)	64	6.90e-02	-0.132000	1.58e-01
NRIF signals cell death from the nucleus	15	3.79e-01	-0.131000	5.23e-01
Metabolism of steroid hormones	15	3.81e-01	-0.131000	5.25e-01
Homology Directed Repair	100	2.46e-02	-0.130000	7.92e-02
PI3K events in ERBB2 signaling	11	4.55e-01	-0.130000	5.97e-01
Regulation of FOXO transcriptional activity by acetylation	10	4.78e-01	-0.130000	6.18e-01
Peptide hormone metabolism	48	1.21e-01	-0.129000	2.35e-01
Activation of RAC1	11	4.58e-01	0.129000	5.99e-01
Transferrin endocytosis and recycling	23	2.83e-01	-0.129000	4.27e-01
G1/S Transition	123	1.41e-02	-0.128000	5.54e-02
Formation of TC-NER Pre-Incision Complex	50	1.18e-01	-0.128000	2.30e-01
RNA polymerase II transcribes snRNA genes	75	5.60e-02	-0.128000	1.39e-01
Cleavage of the damaged purine	11	4.64e-01	-0.127000	6.04e-01
Depurination	11	4.64e-01	-0.127000	6.04e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	4.64e-01	-0.127000	6.04e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	3.34e-02	-0.127000	9.85e-02
Toll Like Receptor 3 (TLR3) Cascade	85	4.39e-02	-0.127000	1.17e-01
Intraflagellar transport	35	1.96e-01	0.126000	3.32e-01
Programmed Cell Death	158	6.44e-03	-0.126000	3.21e-02
Nicotinate metabolism	22	3.08e-01	0.126000	4.57e-01
Antigen processing: Ubiquitination & Proteasome degradation	273	3.72e-04	-0.125000	4.65e-03
Activation of Matrix Metalloproteinases	18	3.58e-01	-0.125000	5.06e-01
Membrane Trafficking	539	7.68e-07	-0.125000	2.50e-05
ER to Golgi Anterograde Transport	122	1.77e-02	-0.124000	6.45e-02
Synthesis of bile acids and bile salts	23	3.03e-01	-0.124000	4.50e-01
Generation of second messenger molecules	11	4.77e-01	-0.124000	6.17e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	2.75e-01	0.124000	4.21e-01
Mitochondrial Fatty Acid Beta-Oxidation	32	2.26e-01	-0.124000	3.65e-01
Signaling by FGFR1 in disease	30	2.43e-01	-0.123000	3.84e-01
Interconversion of nucleotide di- and triphosphates	28	2.59e-01	-0.123000	4.03e-01
Alpha-protein kinase 1 signaling pathway	11	4.80e-01	0.123000	6.19e-01
DNA Repair	274	4.72e-04	-0.123000	5.68e-03
Deposition of new CENPA-containing nucleosomes at the centromere	28	2.60e-01	-0.123000	4.03e-01
Nucleosome assembly	28	2.60e-01	-0.123000	4.03e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	17	3.80e-01	-0.123000	5.24e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	17	3.80e-01	-0.123000	5.24e-01
Separation of Sister Chromatids	162	7.23e-03	-0.122000	3.42e-02
Metabolism of lipids	536	1.39e-06	-0.122000	4.29e-05
Signaling by Non-Receptor Tyrosine Kinases	46	1.52e-01	-0.122000	2.75e-01
Signaling by PTK6	46	1.52e-01	-0.122000	2.75e-01
PIP3 activates AKT signaling	220	1.88e-03	-0.122000	1.43e-02
MET promotes cell motility	27	2.76e-01	-0.121000	4.21e-01
tRNA processing in the nucleus	55	1.20e-01	-0.121000	2.35e-01
Mitochondrial biogenesis	73	7.38e-02	-0.121000	1.65e-01
Mitochondrial translation initiation	88	4.99e-02	-0.121000	1.28e-01
Metabolism of amino acids and derivatives	278	5.35e-04	0.121000	6.04e-03
Myogenesis	21	3.38e-01	-0.121000	4.86e-01
Signalling to ERKs	31	2.45e-01	-0.121000	3.86e-01
Mitochondrial translation termination	88	5.10e-02	-0.120000	1.29e-01
M Phase	330	1.96e-04	-0.120000	2.77e-03
Regulation of KIT signaling	14	4.39e-01	-0.120000	5.81e-01
Elastic fibre formation	34	2.29e-01	0.119000	3.68e-01
HS-GAG degradation	19	3.70e-01	0.119000	5.16e-01
Endogenous sterols	18	3.83e-01	-0.119000	5.26e-01
Interleukin-12 signaling	36	2.20e-01	-0.118000	3.58e-01
Sphingolipid metabolism	74	7.89e-02	-0.118000	1.73e-01
G2/M Checkpoints	124	2.32e-02	-0.118000	7.68e-02
PCNA-Dependent Long Patch Base Excision Repair	21	3.50e-01	-0.118000	4.98e-01
tRNA modification in the nucleus and cytosol	41	1.94e-01	0.117000	3.32e-01
L1CAM interactions	83	6.69e-02	-0.116000	1.54e-01
Amino acid transport across the plasma membrane	18	3.94e-01	-0.116000	5.39e-01
Cargo recognition for clathrin-mediated endocytosis	88	6.07e-02	-0.116000	1.46e-01
E3 ubiquitin ligases ubiquitinate target proteins	42	1.95e-01	-0.116000	3.32e-01
Transport of bile salts and organic acids, metal ions and amine compounds	40	2.06e-01	0.116000	3.42e-01
Processing of Intronless Pre-mRNAs	19	3.84e-01	-0.115000	5.26e-01
CD209 (DC-SIGN) signaling	17	4.10e-01	-0.115000	5.52e-01
Prolonged ERK activation events	14	4.55e-01	-0.115000	5.97e-01
MAPK1/MAPK3 signaling	209	4.17e-03	-0.115000	2.43e-02
Signaling by Hippo	19	3.85e-01	-0.115000	5.28e-01
Interleukin-4 and Interleukin-13 signaling	74	8.72e-02	0.115000	1.83e-01
Mitotic G1 phase and G1/S transition	138	1.99e-02	-0.115000	6.97e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	90	6.04e-02	-0.115000	1.46e-01
Amplification of signal from the kinetochores	90	6.04e-02	-0.115000	1.46e-01
Inositol phosphate metabolism	38	2.22e-01	-0.115000	3.60e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	10	5.31e-01	-0.114000	6.65e-01
Signalling to RAS	18	4.01e-01	-0.114000	5.45e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	3.23e-01	-0.114000	4.70e-01
Synthesis of PC	21	3.66e-01	-0.114000	5.13e-01
Extracellular matrix organization	210	4.46e-03	0.114000	2.50e-02
IRS-mediated signalling	30	2.80e-01	-0.114000	4.25e-01
Signaling by PDGF	46	1.82e-01	0.114000	3.16e-01
tRNA processing	122	3.03e-02	-0.114000	9.28e-02
Signal Transduction	1645	4.04e-14	-0.114000	3.09e-12
Neddylation	205	5.20e-03	-0.113000	2.75e-02
Mitochondrial iron-sulfur cluster biogenesis	12	4.97e-01	0.113000	6.33e-01
B-WICH complex positively regulates rRNA expression	28	3.00e-01	-0.113000	4.48e-01
MTOR signalling	40	2.16e-01	-0.113000	3.56e-01
Anchoring of the basal body to the plasma membrane	90	6.43e-02	0.113000	1.50e-01
Cell junction organization	58	1.37e-01	-0.113000	2.59e-01
Switching of origins to a post-replicative state	85	7.33e-02	-0.112000	1.64e-01
Regulation of insulin secretion	54	1.53e-01	-0.112000	2.77e-01
MyD88 cascade initiated on plasma membrane	76	9.12e-02	-0.112000	1.89e-01
Toll Like Receptor 10 (TLR10) Cascade	76	9.12e-02	-0.112000	1.89e-01
Toll Like Receptor 5 (TLR5) Cascade	76	9.12e-02	-0.112000	1.89e-01
Zinc transporters	11	5.20e-01	-0.112000	6.55e-01
Synthesis of glycosylphosphatidylinositol (GPI)	16	4.38e-01	-0.112000	5.81e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	79	8.58e-02	-0.112000	1.81e-01
RIPK1-mediated regulated necrosis	26	3.25e-01	0.111000	4.71e-01
Regulated Necrosis	26	3.25e-01	0.111000	4.71e-01
Regulation of necroptotic cell death	26	3.25e-01	0.111000	4.71e-01
TICAM1-dependent activation of IRF3/IRF7	11	5.25e-01	0.111000	6.60e-01
Leishmania infection	144	2.20e-02	-0.111000	7.51e-02
Vesicle-mediated transport	554	9.42e-06	-0.111000	2.01e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	3.49e-01	-0.110000	4.98e-01
Macroautophagy	108	4.88e-02	-0.110000	1.25e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	10	5.48e-01	0.110000	6.80e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	68	1.18e-01	-0.110000	2.30e-01
Synthesis of PA	24	3.52e-01	-0.110000	5.00e-01
Autophagy	120	3.84e-02	-0.110000	1.08e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	84	8.34e-02	-0.109000	1.78e-01
Toll Like Receptor 2 (TLR2) Cascade	84	8.34e-02	-0.109000	1.78e-01
Toll Like Receptor TLR1:TLR2 Cascade	84	8.34e-02	-0.109000	1.78e-01
Toll Like Receptor TLR6:TLR2 Cascade	84	8.34e-02	-0.109000	1.78e-01
Formation of the cornified envelope	18	4.24e-01	0.109000	5.69e-01
O-linked glycosylation of mucins	33	2.80e-01	0.109000	4.25e-01
Acetylcholine Neurotransmitter Release Cycle	10	5.54e-01	-0.108000	6.84e-01
Adaptive Immune System	524	2.54e-05	-0.108000	4.93e-04
Nucleobase catabolism	28	3.24e-01	-0.108000	4.70e-01
EML4 and NUDC in mitotic spindle formation	94	7.13e-02	-0.108000	1.61e-01
WNT ligand biogenesis and trafficking	14	4.85e-01	-0.108000	6.24e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	20	4.11e-01	-0.106000	5.53e-01
C-type lectin receptors (CLRs)	103	6.33e-02	-0.106000	1.49e-01
Mitochondrial translation	94	7.62e-02	-0.106000	1.69e-01
VEGFR2 mediated cell proliferation	18	4.39e-01	-0.105000	5.81e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	13	5.12e-01	0.105000	6.47e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	13	5.12e-01	0.105000	6.47e-01
Glycosaminoglycan metabolism	97	7.44e-02	0.105000	1.65e-01
SLBP independent Processing of Histone Pre-mRNAs	10	5.66e-01	0.105000	6.95e-01
Regulation of TP53 Activity	145	2.94e-02	-0.105000	9.11e-02
ISG15 antiviral mechanism	71	1.27e-01	-0.105000	2.46e-01
trans-Golgi Network Vesicle Budding	70	1.30e-01	-0.105000	2.49e-01
Vitamin B5 (pantothenate) metabolism	14	4.98e-01	-0.105000	6.33e-01
Class B/2 (Secretin family receptors)	44	2.31e-01	-0.104000	3.71e-01
Downstream signaling of activated FGFR2	17	4.59e-01	-0.104000	5.99e-01
Signaling by NTRK3 (TRKC)	15	4.87e-01	-0.104000	6.24e-01
mRNA decay by 3’ to 5’ exoribonuclease	15	4.89e-01	-0.103000	6.26e-01
DNA Double-Strand Break Repair	128	4.43e-02	-0.103000	1.17e-01
Mitochondrial translation elongation	88	9.63e-02	-0.103000	1.97e-01
RNA Polymerase I Transcription	43	2.45e-01	-0.103000	3.86e-01
Cyclin E associated events during G1/S transition	76	1.23e-01	-0.102000	2.39e-01
Cilium Assembly	165	2.34e-02	0.102000	7.71e-02
Fc epsilon receptor (FCERI) signaling	110	6.44e-02	-0.102000	1.50e-01
Neurotransmitter receptors and postsynaptic signal transmission	106	6.96e-02	-0.102000	1.59e-01
Synthesis of substrates in N-glycan biosythesis	53	2.00e-01	-0.102000	3.36e-01
PI3K Cascade	27	3.60e-01	-0.102000	5.08e-01
DAP12 interactions	18	4.56e-01	-0.102000	5.97e-01
IL-6-type cytokine receptor ligand interactions	13	5.31e-01	0.100000	6.65e-01
Transcriptional regulation by RUNX3	87	1.07e-01	-0.100000	2.14e-01
Role of phospholipids in phagocytosis	18	4.62e-01	-0.100000	6.03e-01
Mitochondrial protein import	55	2.00e-01	-0.099900	3.36e-01
Toll Like Receptor 4 (TLR4) Cascade	106	7.77e-02	-0.099300	1.71e-01
Processing of Capped Intron-Containing Pre-mRNA	231	9.94e-03	-0.098600	4.40e-02
Signaling by Erythropoietin	21	4.35e-01	-0.098500	5.79e-01
Metabolism of fat-soluble vitamins	30	3.54e-01	0.097800	5.01e-01
DNA Damage Bypass	47	2.49e-01	-0.097300	3.90e-01
Cyclin A:Cdk2-associated events at S phase entry	78	1.40e-01	-0.096700	2.60e-01
Signaling by PDGFR in disease	17	4.90e-01	0.096700	6.26e-01
SARS-CoV-1 Infection	48	2.48e-01	-0.096400	3.89e-01
SLC-mediated transmembrane transport	137	5.39e-02	-0.095500	1.34e-01
Signaling by NOTCH4	76	1.52e-01	-0.095200	2.75e-01
Cell recruitment (pro-inflammatory response)	19	4.73e-01	0.095100	6.13e-01
Purinergic signaling in leishmaniasis infection	19	4.73e-01	0.095100	6.13e-01
SLC transporter disorders	62	1.97e-01	-0.094900	3.32e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR)	34	3.39e-01	-0.094700	4.87e-01
MASTL Facilitates Mitotic Progression	10	6.04e-01	-0.094700	7.26e-01
RNA Polymerase III Chain Elongation	17	5.01e-01	-0.094300	6.37e-01
Signaling by cytosolic FGFR1 fusion mutants	17	5.01e-01	0.094200	6.37e-01
APC/C-mediated degradation of cell cycle proteins	82	1.41e-01	-0.094200	2.60e-01
Regulation of mitotic cell cycle	82	1.41e-01	-0.094200	2.60e-01
G alpha (s) signalling events	73	1.66e-01	-0.093800	2.93e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	172	3.40e-02	-0.093800	9.96e-02
Ovarian tumor domain proteases	33	3.52e-01	-0.093600	5.00e-01
Translesion synthesis by REV1	16	5.17e-01	-0.093500	6.53e-01
Potassium Channels	45	2.78e-01	0.093400	4.23e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	12	5.76e-01	-0.093400	7.03e-01
Signaling by NTRK2 (TRKB)	22	4.50e-01	-0.093000	5.93e-01
DNA Replication Pre-Initiation	79	1.55e-01	-0.092600	2.80e-01
RNA Polymerase I Transcription Initiation	38	3.24e-01	-0.092500	4.70e-01
Transmission across Chemical Synapses	147	5.37e-02	-0.092300	1.34e-01
Innate Immune System	661	5.88e-05	-0.092100	1.02e-03
Nonhomologous End-Joining (NHEJ)	32	3.69e-01	-0.091800	5.16e-01
Golgi Associated Vesicle Biogenesis	55	2.40e-01	-0.091600	3.81e-01
RNA Polymerase III Transcription Termination	22	4.58e-01	-0.091300	5.99e-01
PTEN Regulation	130	7.30e-02	-0.091200	1.64e-01
Class I MHC mediated antigen processing & presentation	314	5.64e-03	-0.091100	2.92e-02
Diseases of carbohydrate metabolism	28	4.07e-01	-0.090600	5.49e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	23	4.53e-01	-0.090300	5.96e-01
O-linked glycosylation	73	1.84e-01	0.090100	3.18e-01
CLEC7A (Dectin-1) signaling	89	1.43e-01	-0.089800	2.64e-01
Cell-Cell communication	84	1.59e-01	-0.089000	2.83e-01
Signaling by Receptor Tyrosine Kinases	401	2.31e-03	-0.089000	1.65e-02
Negative regulators of DDX58/IFIH1 signaling	34	3.70e-01	-0.088900	5.16e-01
Josephin domain DUBs	10	6.29e-01	-0.088200	7.46e-01
CDK-mediated phosphorylation and removal of Cdc6	67	2.13e-01	-0.088100	3.52e-01
RHOBTB GTPase Cycle	17	5.29e-01	-0.088100	6.64e-01
Degradation of GLI2 by the proteasome	53	2.68e-01	-0.087900	4.13e-01
Assembly and cell surface presentation of NMDA receptors	15	5.57e-01	0.087600	6.86e-01
RNA Polymerase I Promoter Clearance	42	3.28e-01	-0.087200	4.74e-01
Downstream signaling events of B Cell Receptor (BCR)	72	2.01e-01	-0.087200	3.37e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	68	2.15e-01	-0.087000	3.55e-01
mRNA Splicing - Major Pathway	171	5.09e-02	-0.086700	1.29e-01
IRAK2 mediated activation of TAK1 complex	10	6.36e-01	-0.086400	7.51e-01
Defective B3GAT3 causes JDSSDHD	16	5.51e-01	0.086200	6.82e-01
GLI3 is processed to GLI3R by the proteasome	53	2.81e-01	-0.085700	4.25e-01
Translesion Synthesis by POLH	19	5.19e-01	0.085500	6.54e-01
GPCR ligand binding	143	7.89e-02	0.085200	1.73e-01
Signaling by FLT3 ITD and TKD mutants	15	5.68e-01	-0.085200	6.97e-01
Ub-specific processing proteases	153	6.94e-02	-0.085200	1.59e-01
FLT3 signaling in disease	26	4.54e-01	-0.084900	5.96e-01
FCERI mediated Ca+2 mobilization	22	4.94e-01	-0.084200	6.31e-01
Heme biosynthesis	12	6.15e-01	-0.083800	7.35e-01
Regulation of APC/C activators between G1/S and early anaphase	75	2.11e-01	-0.083700	3.49e-01
TCR signaling	85	1.83e-01	-0.083700	3.17e-01
Glycogen storage diseases	14	5.88e-01	-0.083600	7.11e-01
Condensation of Prometaphase Chromosomes	10	6.47e-01	-0.083600	7.60e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	5.42e-01	-0.083000	6.74e-01
Antiviral mechanism by IFN-stimulated genes	79	2.05e-01	-0.082600	3.42e-01
mTORC1-mediated signalling	24	4.84e-01	-0.082600	6.23e-01
Disease	1155	3.41e-06	-0.081900	9.04e-05
p75NTR recruits signalling complexes	12	6.25e-01	0.081600	7.42e-01
Pexophagy	11	6.40e-01	0.081600	7.55e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	26	4.73e-01	-0.081300	6.13e-01
Protein methylation	16	5.75e-01	0.080900	7.03e-01
APC/C:Cdc20 mediated degradation of Securin	62	2.72e-01	-0.080600	4.18e-01
Activation of ATR in response to replication stress	37	3.98e-01	-0.080300	5.42e-01
Regulation of RAS by GAPs	57	3.00e-01	-0.079400	4.48e-01
Neutrophil degranulation	323	1.45e-02	-0.079300	5.60e-02
Synthesis of very long-chain fatty acyl-CoAs	16	5.85e-01	-0.078900	7.10e-01
TP53 Regulates Transcription of Death Receptors and Ligands	10	6.66e-01	-0.078900	7.74e-01
Depolymerisation of the Nuclear Lamina	14	6.09e-01	-0.078900	7.31e-01
Metabolism of cofactors	17	5.74e-01	-0.078700	7.03e-01
Centrosome maturation	75	2.39e-01	0.078700	3.79e-01
Recruitment of mitotic centrosome proteins and complexes	75	2.39e-01	0.078700	3.79e-01
Mucopolysaccharidoses	10	6.69e-01	-0.078200	7.76e-01
IGF1R signaling cascade	33	4.39e-01	-0.077900	5.81e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	33	4.39e-01	-0.077900	5.81e-01
FGFR1 mutant receptor activation	24	5.11e-01	-0.077500	6.47e-01
Serotonin Neurotransmitter Release Cycle	11	6.57e-01	-0.077400	7.68e-01
CS/DS degradation	10	6.72e-01	-0.077300	7.80e-01
Mitophagy	26	4.96e-01	-0.077200	6.32e-01
Arachidonic acid metabolism	22	5.34e-01	0.076500	6.67e-01
XBP1(S) activates chaperone genes	45	3.76e-01	-0.076300	5.22e-01
Post-translational protein modification	1115	2.15e-05	-0.076200	4.29e-04
Regulation of ornithine decarboxylase (ODC)	45	3.78e-01	-0.076100	5.22e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	67	2.84e-01	-0.075700	4.28e-01
GPCR downstream signalling	340	1.81e-02	-0.074800	6.53e-02
Immune System	1297	7.68e-06	-0.074800	1.70e-04
Signaling by NTRK1 (TRKA)	105	1.91e-01	-0.074000	3.27e-01
Neurexins and neuroligins	38	4.36e-01	-0.073100	5.79e-01
G alpha (q) signalling events	105	1.97e-01	-0.073000	3.32e-01
Signaling by GPCR	373	1.60e-02	-0.072900	5.88e-02
Dual Incision in GG-NER	40	4.33e-01	-0.071700	5.78e-01
UCH proteinases	78	2.75e-01	-0.071600	4.21e-01
PI-3K cascade:FGFR1	12	6.69e-01	-0.071400	7.76e-01
Degradation of GLI1 by the proteasome	52	3.75e-01	-0.071200	5.21e-01
Activation of SMO	16	6.23e-01	0.071000	7.41e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	10	6.98e-01	-0.070900	8.01e-01
Regulation of signaling by CBL	14	6.47e-01	-0.070600	7.60e-01
Translesion synthesis by POLI	17	6.15e-01	-0.070400	7.35e-01
DNA Double Strand Break Response	42	4.32e-01	-0.070100	5.77e-01
Keratan sulfate/keratin metabolism	26	5.36e-01	0.070100	6.69e-01
Glutathione synthesis and recycling	10	7.02e-01	0.070000	8.04e-01
Metabolism	1546	6.26e-06	-0.069800	1.48e-04
Erythropoietin activates RAS	11	6.89e-01	-0.069700	7.95e-01
ADORA2B mediated anti-inflammatory cytokines production	54	3.76e-01	-0.069600	5.22e-01
Synthesis of PE	10	7.03e-01	-0.069500	8.05e-01
Signaling by NTRKs	122	1.86e-01	-0.069300	3.21e-01
Downstream TCR signaling	71	3.13e-01	-0.069300	4.61e-01
Diseases associated with the TLR signaling cascade	18	6.11e-01	0.069300	7.31e-01
Diseases of Immune System	18	6.11e-01	0.069300	7.31e-01
NF-kB is activated and signals survival	12	6.79e-01	0.068900	7.85e-01
NCAM signaling for neurite out-growth	44	4.29e-01	-0.068900	5.75e-01
mRNA Splicing	182	1.10e-01	-0.068800	2.19e-01
IRS-related events triggered by IGF1R	32	5.05e-01	-0.068100	6.40e-01
Folding of actin by CCT/TriC	10	7.10e-01	-0.068000	8.09e-01
Transcriptional regulation by RUNX2	107	2.27e-01	-0.067700	3.66e-01
PCP/CE pathway	82	2.90e-01	-0.067600	4.36e-01
Killing mechanisms	10	7.14e-01	-0.067000	8.11e-01
WNT5:FZD7-mediated leishmania damping	10	7.14e-01	-0.067000	8.11e-01
TRP channels	15	6.54e-01	-0.066800	7.66e-01
Presynaptic depolarization and calcium channel opening	11	7.03e-01	0.066500	8.05e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	5.43e-01	-0.066400	6.75e-01
GABA synthesis, release, reuptake and degradation	11	7.05e-01	-0.066000	8.05e-01
Selective autophagy	56	3.99e-01	-0.065100	5.43e-01
PI-3K cascade:FGFR4	10	7.24e-01	-0.064500	8.19e-01
TNFR1-induced proapoptotic signaling	12	6.99e-01	0.064400	8.03e-01
Anti-inflammatory response favouring Leishmania parasite infection	74	3.42e-01	-0.063900	4.89e-01
Leishmania parasite growth and survival	74	3.42e-01	-0.063900	4.89e-01
Phase 0 - rapid depolarisation	22	6.05e-01	-0.063700	7.26e-01
Metabolism of porphyrins	17	6.50e-01	-0.063500	7.63e-01
Recruitment of NuMA to mitotic centrosomes	74	3.46e-01	0.063400	4.94e-01
ER Quality Control Compartment (ERQC)	19	6.33e-01	-0.063300	7.49e-01
SARS-CoV-2 Infection	65	3.78e-01	-0.063300	5.22e-01
TNFR1-induced NFkappaB signaling pathway	25	5.85e-01	0.063100	7.10e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	68	3.71e-01	-0.062800	5.17e-01
VLDLR internalisation and degradation	11	7.19e-01	-0.062800	8.15e-01
Plasma lipoprotein clearance	24	6.02e-01	-0.061500	7.24e-01
Signaling by Retinoic Acid	30	5.62e-01	-0.061200	6.92e-01
Signaling by the B Cell Receptor (BCR)	91	3.15e-01	-0.061000	4.63e-01
Protein localization	141	2.13e-01	-0.060800	3.52e-01
RUNX2 regulates bone development	27	5.88e-01	0.060300	7.11e-01
Stimuli-sensing channels	60	4.23e-01	-0.059800	5.69e-01
Cargo trafficking to the periciliary membrane	43	5.05e-01	0.058800	6.40e-01
Mitochondrial tRNA aminoacylation	17	6.76e-01	-0.058500	7.82e-01
Transport of small molecules	450	3.42e-02	-0.058500	1.00e-01
Regulation of TNFR1 signaling	33	5.66e-01	0.057800	6.95e-01
Transcriptional regulation by RUNX1	149	2.25e-01	-0.057600	3.65e-01
Toll-like Receptor Cascades	120	2.76e-01	-0.057600	4.21e-01
Defects in vitamin and cofactor metabolism	19	6.64e-01	-0.057500	7.73e-01
FCERI mediated NF-kB activation	69	4.09e-01	-0.057500	5.52e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	70	4.10e-01	-0.057000	5.52e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	71	4.07e-01	-0.057000	5.49e-01
mRNA 3’-end processing	54	4.70e-01	-0.056900	6.10e-01
Autodegradation of Cdh1 by Cdh1:APC/C	60	4.48e-01	-0.056700	5.91e-01
COPII-mediated vesicle transport	60	4.50e-01	-0.056400	5.93e-01
Downstream signal transduction	26	6.21e-01	0.056100	7.39e-01
Laminin interactions	23	6.42e-01	0.056100	7.56e-01
Metabolism of polyamines	52	4.85e-01	-0.056000	6.23e-01
Regulation of TP53 Degradation	33	5.80e-01	-0.055700	7.08e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	5.40e-01	-0.055300	6.72e-01
Ion channel transport	108	3.22e-01	-0.055200	4.70e-01
Diseases associated with O-glycosylation of proteins	42	5.37e-01	0.055100	6.69e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	30	6.02e-01	-0.055100	7.24e-01
Cytosolic sensors of pathogen-associated DNA	53	4.89e-01	0.055000	6.26e-01
Muscle contraction	104	3.35e-01	-0.054700	4.82e-01
Cell-cell junction organization	34	5.82e-01	0.054600	7.08e-01
DAP12 signaling	17	6.97e-01	-0.054500	8.01e-01
Non-integrin membrane-ECM interactions	37	5.71e-01	-0.053800	7.00e-01
AURKA Activation by TPX2	66	4.51e-01	0.053700	5.93e-01
Interferon Signaling	145	2.66e-01	0.053600	4.10e-01
Nervous system development	475	4.65e-02	0.053500	1.21e-01
Telomere Extension By Telomerase	23	6.60e-01	-0.053100	7.69e-01
Antigen processing-Cross presentation	73	4.34e-01	0.053000	5.78e-01
Interleukin-37 signaling	17	7.11e-01	-0.052000	8.10e-01
Protein-protein interactions at synapses	63	4.81e-01	0.051400	6.20e-01
Assembly of the pre-replicative complex	62	4.87e-01	-0.051100	6.24e-01
Hedgehog ligand biogenesis	57	5.06e-01	0.051000	6.41e-01
Intra-Golgi traffic	40	5.77e-01	0.051000	7.04e-01
TRAF6 mediated IRF7 activation	14	7.41e-01	0.051000	8.36e-01
Class I peroxisomal membrane protein import	20	6.96e-01	0.050400	8.01e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	23	6.76e-01	0.050400	7.82e-01
Trafficking of AMPA receptors	23	6.76e-01	0.050400	7.82e-01
Nuclear Receptor transcription pathway	40	5.84e-01	-0.050000	7.10e-01
Senescence-Associated Secretory Phenotype (SASP)	49	5.50e-01	-0.049400	6.82e-01
SCF(Skp2)-mediated degradation of p27/p21	55	5.27e-01	-0.049400	6.62e-01
Sialic acid metabolism	27	6.58e-01	0.049200	7.69e-01
Regulation of TP53 Activity through Phosphorylation	86	4.31e-01	-0.049100	5.77e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	12	7.69e-01	-0.049000	8.58e-01
Metabolism of proteins	1578	1.41e-03	-0.048900	1.16e-02
Disorders of transmembrane transporters	122	3.52e-01	-0.048800	5.00e-01
Signaling by FLT3 fusion proteins	18	7.22e-01	-0.048400	8.18e-01
rRNA modification in the nucleus and cytosol	59	5.20e-01	0.048400	6.55e-01
IRE1alpha activates chaperones	47	5.67e-01	-0.048300	6.96e-01
G alpha (i) signalling events	175	2.76e-01	-0.047800	4.21e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	31	6.47e-01	0.047600	7.60e-01
Degradation of the extracellular matrix	73	4.84e-01	0.047400	6.23e-01
Axon guidance	455	8.55e-02	0.047200	1.81e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	7.79e-01	-0.046800	8.65e-01
Metabolism of carbohydrates	235	2.18e-01	-0.046800	3.57e-01
Iron uptake and transport	47	5.85e-01	-0.046100	7.10e-01
Plasma lipoprotein assembly, remodeling, and clearance	44	5.98e-01	0.046000	7.20e-01
Negative regulation of NOTCH4 signaling	49	5.82e-01	-0.045500	7.08e-01
Elevation of cytosolic Ca2+ levels	10	8.05e-01	0.045100	8.76e-01
TRAF3-dependent IRF activation pathway	12	7.88e-01	-0.044900	8.68e-01
Orc1 removal from chromatin	65	5.33e-01	-0.044800	6.67e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	13	7.81e-01	-0.044600	8.65e-01
Translesion synthesis by POLK	17	7.50e-01	-0.044600	8.45e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	7.92e-01	0.044100	8.69e-01
alpha-linolenic acid (ALA) metabolism	12	7.92e-01	0.044100	8.69e-01
G1/S DNA Damage Checkpoints	60	5.56e-01	-0.043900	6.86e-01
Degradation of AXIN	49	5.97e-01	-0.043700	7.19e-01
Glycosphingolipid metabolism	36	6.53e-01	-0.043300	7.65e-01
Signaling by Activin	12	7.96e-01	-0.043200	8.70e-01
Infectious disease	619	6.96e-02	-0.043000	1.59e-01
Translation of structural proteins	28	6.96e-01	-0.042700	8.01e-01
Regulation of RUNX2 expression and activity	65	5.52e-01	-0.042700	6.83e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	49	6.16e-01	-0.041400	7.35e-01
Glutamate Neurotransmitter Release Cycle	16	7.75e-01	-0.041400	8.61e-01
RNA Polymerase I Transcription Termination	25	7.21e-01	-0.041300	8.17e-01
Regulation of PTEN mRNA translation	13	7.97e-01	-0.041200	8.70e-01
Metabolic disorders of biological oxidation enzymes	21	7.47e-01	-0.040700	8.42e-01
Platelet calcium homeostasis	18	7.65e-01	0.040700	8.55e-01
Processing of Capped Intronless Pre-mRNA	28	7.12e-01	-0.040300	8.10e-01
Asparagine N-linked glycosylation	255	2.76e-01	-0.039700	4.21e-01
Phase II - Conjugation of compounds	52	6.22e-01	0.039600	7.40e-01
Response of EIF2AK1 (HRI) to heme deficiency	15	7.92e-01	0.039400	8.69e-01
Loss of Nlp from mitotic centrosomes	63	5.90e-01	0.039300	7.12e-01
Loss of proteins required for interphase microtubule organization from the centrosome	63	5.90e-01	0.039300	7.12e-01
Hedgehog ‘on’ state	77	5.52e-01	-0.039200	6.83e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	20	7.64e-01	-0.038700	8.55e-01
Regulation of RUNX3 expression and activity	50	6.36e-01	-0.038700	7.51e-01
IRAK1 recruits IKK complex	10	8.33e-01	-0.038500	8.95e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	8.33e-01	-0.038500	8.95e-01
Ubiquitin-dependent degradation of Cyclin D	46	6.53e-01	-0.038400	7.65e-01
Signaling by SCF-KIT	33	7.06e-01	0.037900	8.06e-01
NGF-stimulated transcription	34	7.04e-01	-0.037600	8.05e-01
Termination of translesion DNA synthesis	31	7.17e-01	-0.037600	8.14e-01
Nephrin family interactions	18	7.83e-01	0.037400	8.67e-01
Transport to the Golgi and subsequent modification	149	4.35e-01	-0.037100	5.79e-01
RUNX2 regulates osteoblast differentiation	21	7.70e-01	0.036900	8.58e-01
Mitotic Prometaphase	178	3.97e-01	-0.036900	5.41e-01
ER-Phagosome pathway	64	6.11e-01	0.036800	7.31e-01
Defects in cobalamin (B12) metabolism	11	8.33e-01	0.036600	8.95e-01
SCF-beta-TrCP mediated degradation of Emi1	49	6.60e-01	-0.036400	7.69e-01
Platelet sensitization by LDL	14	8.15e-01	-0.036200	8.86e-01
Transcriptional regulation of granulopoiesis	28	7.41e-01	-0.036100	8.36e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	8.44e-01	-0.035900	9.02e-01
RNA Polymerase I Promoter Escape	25	7.59e-01	0.035400	8.52e-01
Interleukin-12 family signaling	43	6.89e-01	-0.035300	7.95e-01
Diseases of glycosylation	107	5.33e-01	0.034900	6.67e-01
Glutathione conjugation	24	7.70e-01	-0.034600	8.58e-01
Unfolded Protein Response (UPR)	85	5.88e-01	0.034000	7.11e-01
Organelle biogenesis and maintenance	238	3.70e-01	0.033800	5.16e-01
Cell surface interactions at the vascular wall	72	6.25e-01	-0.033300	7.42e-01
PINK1-PRKN Mediated Mitophagy	20	7.98e-01	0.033000	8.71e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	8.21e-01	0.032700	8.87e-01
tRNA Aminoacylation	23	7.87e-01	-0.032500	8.68e-01
WNT5A-dependent internalization of FZD4	14	8.35e-01	-0.032100	8.95e-01
RNA Polymerase II Transcription Termination	63	6.62e-01	-0.031900	7.71e-01
Regulation of TP53 Activity through Methylation	18	8.17e-01	-0.031600	8.86e-01
Diseases associated with N-glycosylation of proteins	17	8.24e-01	0.031200	8.88e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	8.58e-01	0.031200	9.11e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	33	7.58e-01	0.031100	8.51e-01
Metabolism of folate and pterines	15	8.36e-01	0.030900	8.95e-01
Methylation	11	8.60e-01	0.030700	9.13e-01
Interleukin receptor SHC signaling	14	8.45e-01	-0.030100	9.02e-01
Regulation of PLK1 Activity at G2/M Transition	81	6.41e-01	0.030000	7.56e-01
MET activates PTK2 signaling	17	8.36e-01	-0.029100	8.95e-01
Nuclear signaling by ERBB4	25	8.02e-01	0.028900	8.74e-01
Blood group systems biosynthesis	11	8.68e-01	-0.028900	9.18e-01
Other interleukin signaling	15	8.47e-01	-0.028800	9.03e-01
Neurotransmitter release cycle	29	7.93e-01	-0.028200	8.69e-01
Regulation of TP53 Expression and Degradation	34	7.83e-01	-0.027300	8.67e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	7.73e-01	-0.027100	8.60e-01
Interleukin-1 family signaling	109	6.31e-01	-0.026700	7.47e-01
Metabolism of steroids	111	6.29e-01	-0.026500	7.46e-01
Tie2 Signaling	12	8.76e-01	-0.026100	9.23e-01
TNF signaling	41	7.73e-01	0.026000	8.60e-01
Condensation of Prophase Chromosomes	14	8.67e-01	-0.025900	9.17e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	8.82e-01	-0.025800	9.28e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	8.18e-01	-0.025600	8.86e-01
Fanconi Anemia Pathway	37	7.95e-01	-0.024600	8.70e-01
Calnexin/calreticulin cycle	24	8.36e-01	0.024400	8.95e-01
Cytochrome P450 - arranged by substrate type	30	8.21e-01	-0.023800	8.87e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	44	7.85e-01	0.023800	8.67e-01
Autodegradation of the E3 ubiquitin ligase COP1	46	7.84e-01	0.023400	8.67e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	59	7.58e-01	-0.023200	8.51e-01
Peroxisomal protein import	54	7.70e-01	-0.023000	8.58e-01
Stabilization of p53	50	7.80e-01	0.022800	8.65e-01
Gene expression (Transcription)	1223	1.93e-01	-0.022300	3.31e-01
Retrograde transport at the Trans-Golgi-Network	47	7.93e-01	-0.022100	8.69e-01
Ion transport by P-type ATPases	32	8.32e-01	0.021700	8.95e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	28	8.45e-01	-0.021400	9.02e-01
Netrin-1 signaling	40	8.18e-01	-0.021000	8.86e-01
Cross-presentation of soluble exogenous antigens (endosomes)	40	8.19e-01	0.020900	8.86e-01
p53-Dependent G1 DNA Damage Response	58	7.89e-01	-0.020300	8.68e-01
p53-Dependent G1/S DNA damage checkpoint	58	7.89e-01	-0.020300	8.68e-01
Developmental Biology	708	3.62e-01	-0.020200	5.10e-01
SARS-CoV Infections	126	6.97e-01	-0.020100	8.01e-01
NOD1/2 Signaling Pathway	29	8.54e-01	-0.019800	9.08e-01
ABC-family proteins mediated transport	80	7.61e-01	0.019700	8.52e-01
Ion homeostasis	32	8.47e-01	-0.019700	9.03e-01
Fatty acyl-CoA biosynthesis	25	8.65e-01	-0.019600	9.16e-01
Signaling by Interleukins	315	5.55e-01	-0.019400	6.85e-01
Activation of NF-kappaB in B cells	60	7.96e-01	-0.019300	8.70e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	48	8.19e-01	-0.019100	8.86e-01
Synaptic adhesion-like molecules	14	9.02e-01	-0.018900	9.46e-01
Lysine catabolism	11	9.16e-01	0.018300	9.56e-01
Defective CFTR causes cystic fibrosis	52	8.22e-01	-0.018000	8.87e-01
Peroxisomal lipid metabolism	25	8.79e-01	0.017500	9.26e-01
TRAF6 mediated NF-kB activation	20	8.94e-01	-0.017300	9.39e-01
Biological oxidations	105	7.63e-01	0.017100	8.54e-01
Incretin synthesis, secretion, and inactivation	13	9.15e-01	-0.017000	9.56e-01
Interleukin-1 signaling	89	7.87e-01	-0.016600	8.68e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	43	8.52e-01	0.016500	9.07e-01
Activation of gene expression by SREBF (SREBP)	42	8.62e-01	-0.015500	9.13e-01
Mitotic G2-G2/M phases	170	7.30e-01	-0.015400	8.25e-01
Regulation of Apoptosis	47	8.62e-01	0.014700	9.13e-01
Caspase activation via Death Receptors in the presence of ligand	14	9.25e-01	-0.014500	9.59e-01
Hedgehog ‘off’ state	87	8.17e-01	-0.014300	8.86e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	57	8.56e-01	-0.013900	9.10e-01
Signaling by ERBB4	43	8.74e-01	0.013900	9.23e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	9.32e-01	-0.013600	9.63e-01
Visual phototransduction	50	8.75e-01	0.012900	9.23e-01
PI-3K cascade:FGFR2	11	9.43e-01	0.012400	9.71e-01
Metabolism of water-soluble vitamins and cofactors	95	8.37e-01	-0.012200	8.95e-01
Keratan sulfate biosynthesis	21	9.24e-01	0.012100	9.59e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	9.45e-01	0.011500	9.72e-01
Potential therapeutics for SARS	62	8.76e-01	0.011500	9.23e-01
Keratinization	27	9.21e-01	-0.011000	9.59e-01
Cargo concentration in the ER	26	9.23e-01	-0.010900	9.59e-01
Asymmetric localization of PCP proteins	57	8.98e-01	0.009770	9.43e-01
NIK–>noncanonical NF-kB signaling	53	9.04e-01	0.009590	9.46e-01
Cellular response to hypoxia	64	8.97e-01	-0.009390	9.42e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	20	9.42e-01	-0.009380	9.70e-01
Regulation of PTEN stability and activity	60	9.04e-01	-0.009000	9.46e-01
Integrin cell surface interactions	50	9.13e-01	0.008940	9.54e-01
Glycogen breakdown (glycogenolysis)	14	9.55e-01	-0.008790	9.75e-01
Cytokine Signaling in Immune system	479	7.49e-01	-0.008560	8.44e-01
Cellular responses to stress	458	7.55e-01	0.008550	8.49e-01
Vpu mediated degradation of CD4	45	9.26e-01	-0.008000	9.59e-01
Degradation of DVL	51	9.23e-01	-0.007810	9.59e-01
Dopamine Neurotransmitter Release Cycle	15	9.58e-01	0.007760	9.77e-01
Glycogen metabolism	25	9.47e-01	0.007660	9.72e-01
Adherens junctions interactions	18	9.57e-01	0.007420	9.75e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	9.57e-01	0.007410	9.75e-01
Transcriptional regulation of pluripotent stem cells	19	9.56e-01	-0.007370	9.75e-01
CDT1 association with the CDC6:ORC:origin complex	53	9.26e-01	-0.007350	9.59e-01
Retrograde neurotrophin signalling	14	9.64e-01	0.007020	9.79e-01
Caspase activation via extrinsic apoptotic signalling pathway	22	9.55e-01	-0.006890	9.75e-01
Miscellaneous transport and binding events	19	9.59e-01	0.006740	9.77e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	9.31e-01	0.006730	9.62e-01
Cardiac conduction	70	9.28e-01	0.006280	9.59e-01
Lewis blood group biosynthesis	10	9.74e-01	-0.006000	9.86e-01
Platelet homeostasis	56	9.41e-01	0.005680	9.70e-01
TNFR2 non-canonical NF-kB pathway	70	9.36e-01	-0.005540	9.66e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	11	9.76e-01	0.005210	9.87e-01
RAB geranylgeranylation	55	9.47e-01	-0.005170	9.72e-01
Post-translational modification: synthesis of GPI-anchored proteins	46	9.55e-01	-0.004800	9.75e-01
Vif-mediated degradation of APOBEC3G	46	9.56e-01	0.004700	9.75e-01
TNFs bind their physiological receptors	10	9.80e-01	0.004550	9.89e-01
Generic Transcription Pathway	981	8.19e-01	0.004360	8.86e-01
G2/M Transition	168	9.23e-01	-0.004300	9.59e-01
Diseases of metabolism	177	9.24e-01	-0.004150	9.59e-01
Hh mutants abrogate ligand secretion	51	9.61e-01	-0.003980	9.77e-01
Signaling by Hedgehog	122	9.47e-01	-0.003520	9.72e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	61	9.66e-01	0.003170	9.80e-01
Metabolism of vitamins and cofactors	141	9.49e-01	0.003130	9.73e-01
Hh mutants are degraded by ERAD	50	9.74e-01	-0.002690	9.86e-01
Metabolism of RNA	650	9.08e-01	-0.002680	9.49e-01
Cellular responses to external stimuli	466	9.23e-01	-0.002620	9.59e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	53	9.74e-01	-0.002570	9.86e-01
Phase I - Functionalization of compounds	51	9.78e-01	-0.002280	9.87e-01
Cytosolic sulfonation of small molecules	11	9.90e-01	0.002100	9.94e-01
Neuronal System	225	9.61e-01	0.001890	9.77e-01
Interaction between L1 and Ankyrins	18	9.90e-01	-0.001690	9.94e-01
TP53 Regulates Transcription of Cell Death Genes	39	9.88e-01	-0.001420	9.94e-01
Amine ligand-binding receptors	14	9.93e-01	-0.001300	9.95e-01
CD28 dependent PI3K/Akt signaling	16	9.94e-01	-0.001100	9.95e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	46	9.91e-01	0.000996	9.94e-01
p53-Independent DNA Damage Response	46	9.91e-01	0.000996	9.94e-01
p53-Independent G1/S DNA damage checkpoint	46	9.91e-01	0.000996	9.94e-01
ABC transporter disorders	60	9.90e-01	-0.000909	9.94e-01
Fatty acid metabolism	116	9.90e-01	0.000663	9.94e-01
RNA Polymerase II Transcription	1104	9.73e-01	0.000620	9.86e-01
Dectin-1 mediated noncanonical NF-kB signaling	54	9.96e-01	0.000393	9.97e-01
Chaperone Mediated Autophagy	16	9.99e-01	0.000180	9.99e-01

---

Detailed Gene set reports

Interleukin-35 Signalling

Interleukin-35 Signalling

	522
set	Interleukin-35 Signalling
setSize	10
pANOVA	0.000252
s.dist	0.668
p.adjustANOVA	0.00328

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JAK2	7829
IL6ST	7817
STAT3	7512
IL27RA	7071
STAT4	5785
JAK1	5149
IL12A	4522
STAT1	3403
CANX	2787
TYK2	-53

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JAK2	7829
IL6ST	7817
STAT3	7512
IL27RA	7071
STAT4	5785
JAK1	5149
IL12A	4522
STAT1	3403
CANX	2787
TYK2	-53

---

Peptide chain elongation

Peptide chain elongation

	755
set	Peptide chain elongation
setSize	85
pANOVA	1.38e-24
s.dist	0.642
p.adjustANOVA	1.79e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
EEF2	7264
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
EEF2	7264
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
EEF1A1	1902
RPS26	1750
FAU	1155
RPSA	-420
RPL26L1	-949
RPL36AL	-2092
RPS27L	-2397
RPL39L	-2911
RPS28	-4755
RPLP2	-4796

---

Viral mRNA Translation

Viral mRNA Translation

	1253
set	Viral mRNA Translation
setSize	85
pANOVA	4.65e-24
s.dist	0.634
p.adjustANOVA	1.93e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
DNAJC3	5385
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
RPS26	1750
FAU	1155
RPSA	-420
RPL26L1	-949
GRSF1	-1214
RPL36AL	-2092
RPS27L	-2397
RPL39L	-2911
RPS28	-4755
RPLP2	-4796

---

Selenocysteine synthesis

Selenocysteine synthesis

	1000
set	Selenocysteine synthesis
setSize	88
pANOVA	3.64e-24
s.dist	0.625
p.adjustANOVA	1.93e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
EEFSEC	4157
RPL18A	4115
SEPSECS	4064
RPS12	4048
PSTK	3914
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
RPS26	1750
FAU	1155
SEPHS2	712
RPSA	-420
SECISBP2	-656
RPL26L1	-949
RPL36AL	-2092
RPS27L	-2397
RPL39L	-2911
RPS28	-4755
RPLP2	-4796

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	320
set	Eukaryotic Translation Elongation
setSize	89
pANOVA	7.42e-24
s.dist	0.617
p.adjustANOVA	1.93e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
EEF2	7264
RPL10A	7263
RPL8	7250
EEF1B2	7240
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
EEF2	7264
RPL10A	7263
RPL8	7250
EEF1B2	7240
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
EEF1A1P5	4929
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
EEF1A1	1902
RPS26	1750
FAU	1155
RPSA	-420
RPL26L1	-949
EEF1D	-1847
RPL36AL	-2092
RPS27L	-2397
RPL39L	-2911
RPS28	-4755
RPLP2	-4796
EEF1A2	-8004

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	322
set	Eukaryotic Translation Termination
setSize	89
pANOVA	2.09e-22
s.dist	0.597
p.adjustANOVA	3.89e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
GSPT1	2038
RPL22L1	1964
RPS26	1750
FAU	1155
APEH	1035
N6AMT1	720
ETF1	-382
RPSA	-420
RPL26L1	-949
RPL36AL	-2092
RPS27L	-2397
RPL39L	-2911
GSPT2	-2915
TRMT112	-3437
RPS28	-4755
RPLP2	-4796

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	999
set	Selenoamino acid metabolism
setSize	101
pANOVA	6.14e-24
s.dist	0.581
p.adjustANOVA	1.93e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NNMT	7816
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NNMT	7816
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
PAPSS2	6573
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
SCLY	6003
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
PAPSS1	5772
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
GSR	4237
EEFSEC	4157
AIMP1	4126
RPL18A	4115
SEPSECS	4064
RPS12	4048
PSTK	3914
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
RPS26	1750
TXNRD1	1443
FAU	1155
SEPHS2	712
EEF1E1	458
AHCY	-175
RPSA	-420
SECISBP2	-656
HNMT	-669
RPL26L1	-949
RPL36AL	-2092
RPS27L	-2397
CTH	-2457
AIMP2	-2901
RPL39L	-2911
CBS	-3626
RPS28	-4755
RPLP2	-4796

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	948
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	97
pANOVA	9.13e-23
s.dist	0.577
p.adjustANOVA	1.98e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
CEBPB	6860
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
ATF4	6010
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
IMPACT	5444
RPL7A	5345
EIF2S3	5156
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
ATF3	3783
EIF2S2	3756
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
RPS26	1750
FAU	1155
ASNS	1122
EIF2S1	1072
ATF2	-106
CEBPG	-232
RPSA	-420
DDIT3	-705
RPL26L1	-949
RPL36AL	-2092
RPS27L	-2397
TRIB3	-2512
RPL39L	-2911
GCN1	-4138
RPS28	-4755
RPLP2	-4796
EIF2AK4	-7460

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	695
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	91
pANOVA	1.49e-20
s.dist	0.563
p.adjustANOVA	1.79e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
GSPT1	2038
RPL22L1	1964
RPS26	1750
FAU	1155
ETF1	-382
RPSA	-420
RPL26L1	-949
NCBP2	-2083
RPL36AL	-2092
RPS27L	-2397
EIF4G1	-2493
RPL39L	-2911
GSPT2	-2915
PABPC1	-3146
NCBP1	-3996
RPS28	-4755
RPLP2	-4796
UPF1	-4980

---

Interleukin-6 signaling

Interleukin-6 signaling

	526
set	Interleukin-6 signaling
setSize	11
pANOVA	0.00128
s.dist	0.561
p.adjustANOVA	0.0108

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL6	7832
JAK2	7829
IL6ST	7817
IL6R	7681
SOCS3	7610
STAT3	7512
JAK1	5149
STAT1	3403
PTPN11	435
TYK2	-53
CBL	-7686

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL6	7832
JAK2	7829
IL6ST	7817
IL6R	7681
SOCS3	7610
STAT3	7512
JAK1	5149
STAT1	3403
PTPN11	435
TYK2	-53
CBL	-7686

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	360
set	Formation of a pool of free 40S subunits
setSize	97
pANOVA	1.39e-21
s.dist	0.56
p.adjustANOVA	2.27e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
EIF3M	6006
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
EIF3D	4212
RPL18A	4115
RPS12	4048
EIF3E	3912
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
EIF3A	3092
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
EIF3F	2186
RPS17	2073
RPL22L1	1964
RPS26	1750
EIF3L	1225
FAU	1155
EIF3G	978
EIF3J	849
RPSA	-420
EIF3K	-591
EIF3H	-785
RPL26L1	-949
EIF3B	-1725
RPL36AL	-2092
RPS27L	-2397
RPL39L	-2911
EIF3C	-3245
EIF1AX	-4390
RPS28	-4755
RPLP2	-4796
EIF3I	-6241

---

Activation of BAD and translocation to mitochondria

Activation of BAD and translocation to mitochondria

	31
set	Activation of BAD and translocation to mitochondria
setSize	12
pANOVA	0.000812
s.dist	-0.558
p.adjustANOVA	0.00771

Top enriched genes

Top 20 genes

GeneID	Gene Rank
YWHAQ	-8005
YWHAZ	-7497
BAD	-7271
YWHAH	-7222
YWHAG	-6528
AKT1	-5885
YWHAB	-5495
PPP3R1	-4946
AKT2	-3273
BID	-1220
PPP3CC	-1068
BCL2	3051

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
YWHAQ	-8005
YWHAZ	-7497
BAD	-7271
YWHAH	-7222
YWHAG	-6528
AKT1	-5885
YWHAB	-5495
PPP3R1	-4946
AKT2	-3273
BID	-1220
PPP3CC	-1068
BCL2	3051

---

Signaling by Leptin

Signaling by Leptin

	1050
set	Signaling by Leptin
setSize	10
pANOVA	0.00269
s.dist	0.548
p.adjustANOVA	0.0179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JAK2	7829
SOCS3	7610
STAT3	7512
STAT5A	7092
IRS1	6127
LEPR	4918
IRS2	2726
PTPN11	435
SH2B1	-873
STAT5B	-1159

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JAK2	7829
SOCS3	7610
STAT3	7512
STAT5A	7092
IRS1	6127
LEPR	4918
IRS2	2726
PTPN11	435
SH2B1	-873
STAT5B	-1159

---

Chemokine receptors bind chemokines

Chemokine receptors bind chemokines

	156
set	Chemokine receptors bind chemokines
setSize	13
pANOVA	0.000971
s.dist	0.528
p.adjustANOVA	0.00889

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CXCL12	7764
CXCL8	7701
ACKR3	7686
CXCL1	7669
CXCL16	7218
CXCL3	6695
CXCL2	6615
CCL2	6486
CXCL10	5538
CX3CL1	2915
CXCL11	-2762
CCL28	-4965
CXCR4	-5734

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CXCL12	7764
CXCL8	7701
ACKR3	7686
CXCL1	7669
CXCL16	7218
CXCL3	6695
CXCL2	6615
CCL2	6486
CXCL10	5538
CX3CL1	2915
CXCL11	-2762
CCL28	-4965
CXCR4	-5734

---

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

	358
set	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
setSize	11
pANOVA	0.00257
s.dist	-0.525
p.adjustANOVA	0.0177

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1A	-7902
LMNB1	-7606
HMGA2	-7482
UBN1	-6169
HMGA1	-5337
HIRA	-5319
CABIN1	-4329
RB1	-4096
ASF1A	-3941
EP400	-2000
TP53	6352

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1A	-7902
LMNB1	-7606
HMGA2	-7482
UBN1	-6169
HMGA1	-5337
HIRA	-5319
CABIN1	-4329
RB1	-4096
ASF1A	-3941
EP400	-2000
TP53	6352

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	546
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	107
pANOVA	8.22e-21
s.dist	0.523
p.adjustANOVA	1.19e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
EIF3M	6006
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
EIF2S3	5156
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
EIF4A1	4517
RPS20	4323
EIF3D	4212
RPL18A	4115
RPS12	4048
EIF3E	3912
RPS5	3813
EIF2S2	3756
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
EIF3A	3092
UBA52	2829
EIF4B	2587
RPS29	2299
RPLP0	2239
RPL14	2227
EIF3F	2186
RPS17	2073
RPL22L1	1964
RPS26	1750
EIF3L	1225
FAU	1155
EIF2S1	1072
EIF3G	978
EIF3J	849
RPSA	-420
EIF3K	-591
EIF3H	-785
RPL26L1	-949
EIF3B	-1725
EIF4E	-1791
RPL36AL	-2092
RPS27L	-2397
EIF4G1	-2493
RPL39L	-2911
PABPC1	-3146
EIF3C	-3245
EIF1AX	-4390
RPS28	-4755
RPLP2	-4796
EIF4H	-5641
EIF3I	-6241

---

RHO GTPases activate KTN1

RHO GTPases activate KTN1

	834
set	RHO GTPases activate KTN1
setSize	10
pANOVA	0.00453
s.dist	-0.518
p.adjustANOVA	0.0253

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAC1	-7875
RHOA	-7560
CDC42	-7346
KLC2	-6543
RHOG	-6426
KIF5B	-6292
KIF5A	-5725
KLC1	-4607
KLC4	2032
KTN1	7391

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAC1	-7875
RHOA	-7560
CDC42	-7346
KLC2	-6543
RHOG	-6426
KIF5B	-6292
KIF5A	-5725
KLC1	-4607
KLC4	2032
KTN1	7391

---

Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine

	245
set	Degradation of cysteine and homocysteine
setSize	11
pANOVA	0.00296
s.dist	-0.517
p.adjustANOVA	0.0187

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TST	-7965
ADO	-7884
GOT2	-7808
SLC25A10	-6670
TXN2	-5081
ETHE1	-4561
SUOX	-2761
CTH	-2457
CSAD	-2245
SQRDL	-46
MPST	318

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TST	-7965
ADO	-7884
GOT2	-7808
SLC25A10	-6670
TXN2	-5081
ETHE1	-4561
SUOX	-2761
CTH	-2457
CSAD	-2245
SQRDL	-46
MPST	318

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	400
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	108
pANOVA	1.51e-20
s.dist	0.517
p.adjustANOVA	1.79e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
EIF3M	6006
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
EIF2S3	5156
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
EIF4A1	4517
RPS20	4323
EIF3D	4212
RPL18A	4115
RPS12	4048
EIF3E	3912
RPS5	3813
EIF2S2	3756
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
EIF3A	3092
UBA52	2829
EIF4B	2587
RPS29	2299
RPLP0	2239
RPL14	2227
EIF3F	2186
RPS17	2073
RPL22L1	1964
RPS26	1750
EIF3L	1225
FAU	1155
EIF2S1	1072
EIF3G	978
EIF3J	849
RPSA	-420
EIF3K	-591
EIF3H	-785
RPL26L1	-949
EIF3B	-1725
EIF4E	-1791
EIF5B	-1945
RPL36AL	-2092
EIF5	-2378
RPS27L	-2397
EIF4G1	-2493
RPL39L	-2911
EIF3C	-3245
EIF1AX	-4390
RPS28	-4755
RPLP2	-4796
EIF4H	-5641
EIF3I	-6241

---

Synthesis of PIPs at the Golgi membrane

Synthesis of PIPs at the Golgi membrane

	1115
set	Synthesis of PIPs at the Golgi membrane
setSize	15
pANOVA	0.000586
s.dist	-0.513
p.adjustANOVA	0.0064

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIKFYVE	-7744
PI4K2A	-7435
ARF3	-7339
SACM1L	-6755
PI4KA	-6411
FIG4	-6361
OCRL	-6163
VAC14	-6142
ARF1	-5829
PI4K2B	-5349
PIK3R4	-3592
INPP5E	-948
PI4KB	-571
PIK3C3	3264
PIK3C2A	3650

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIKFYVE	-7744
PI4K2A	-7435
ARF3	-7339
SACM1L	-6755
PI4KA	-6411
FIG4	-6361
OCRL	-6163
VAC14	-6142
ARF1	-5829
PI4K2B	-5349
PIK3R4	-3592
INPP5E	-948
PI4KB	-571
PIK3C3	3264
PIK3C2A	3650

---

RHO GTPases activate IQGAPs

RHO GTPases activate IQGAPs

	833
set	RHO GTPases activate IQGAPs
setSize	10
pANOVA	0.00531
s.dist	-0.509
p.adjustANOVA	0.028

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAC1	-7875
CALM1	-7505
CDC42	-7346
CTNNA1	-7043
IQGAP3	-5911
IQGAP1	-4911
CTNNB1	-4351
MEN1	-3046
CLIP1	954
IQGAP2	4826

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAC1	-7875
CALM1	-7505
CDC42	-7346
CTNNA1	-7043
IQGAP3	-5911
IQGAP1	-4911
CTNNB1	-4351
MEN1	-3046
CLIP1	954
IQGAP2	4826

---

MAPK3 (ERK1) activation

MAPK3 (ERK1) activation

	572
set	MAPK3 (ERK1) activation
setSize	10
pANOVA	0.00548
s.dist	0.507
p.adjustANOVA	0.0286

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL6	7832
JAK2	7829
IL6ST	7817
IL6R	7681
JAK1	5149
MAP2K1	3202
CDK1	544
PTPN11	435
TYK2	-53
MAPK3	-1487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL6	7832
JAK2	7829
IL6ST	7817
IL6R	7681
JAK1	5149
MAP2K1	3202
CDK1	544
PTPN11	435
TYK2	-53
MAPK3	-1487

---

Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the early endosome membrane

	1116
set	Synthesis of PIPs at the early endosome membrane
setSize	15
pANOVA	0.000804
s.dist	-0.5
p.adjustANOVA	0.00769

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTMR2	-8132
INPP4B	-8091
MTMR4	-8026
MTMR12	-7782
PIKFYVE	-7744
PI4K2A	-7435
INPP5F	-7392
FIG4	-6361
VAC14	-6142
PI4K2B	-5349
PIK3R4	-3592
MTM1	2934
PIK3C3	3264
PIK3C2A	3650
INPP4A	4012

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTMR2	-8132
INPP4B	-8091
MTMR4	-8026
MTMR12	-7782
PIKFYVE	-7744
PI4K2A	-7435
INPP5F	-7392
FIG4	-6361
VAC14	-6142
PI4K2B	-5349
PIK3R4	-3592
MTM1	2934
PIK3C3	3264
PIK3C2A	3650
INPP4A	4012

---

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

	1298
set	tRNA processing in the mitochondrion
setSize	24
pANOVA	3.01e-05
s.dist	-0.492
p.adjustANOVA	0.00055

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND2	-8080
MT-CO2	-7984
MT-ND1	-7938
MT-CO1	-7848
MT-ATP6	-7777
MT-CO3	-7751
MT-CYB	-7639
MT-ND5	-7183
MT-ATP8	-7080
MT-ND3	-6630
MT-ND4L	-5673
MT-ND4	-4961
MT-ND6	-4202
MT-TP	-4196
MT-TW	-3435
MT-TT	-2837
ELAC2	-2355
MT-RNR2	-1452
MT-TA	-892
TRMT10C	-756

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND2	-8080
MT-CO2	-7984
MT-ND1	-7938
MT-CO1	-7848
MT-ATP6	-7777
MT-CO3	-7751
MT-CYB	-7639
MT-ND5	-7183
MT-ATP8	-7080
MT-ND3	-6630
MT-ND4L	-5673
MT-ND4	-4961
MT-ND6	-4202
MT-TP	-4196
MT-TW	-3435
MT-TT	-2837
ELAC2	-2355
MT-RNR2	-1452
MT-TA	-892
TRMT10C	-756
MT-RNR1	-287
HSD17B10	142
MT-TI	1672
TRNT1	7180

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	980
set	SRP-dependent cotranslational protein targeting to membrane
setSize	108
pANOVA	2.11e-18
s.dist	0.487
p.adjustANOVA	2.29e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
SEC11A	6650
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
SRPRB	5207
DDOST	5180
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
RPS20	4323
RPL18A	4115
RPS12	4048
SSR1	4040
SEC61B	3969
RPS5	3813
RPS2	3733
RPS27	3395
TRAM1	3289
RPS9	3266
RPS13	3116
SSR3	2984
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
RPL22L1	1964
RPS26	1750
SPCS3	1333
FAU	1155
SRP19	1080
SRP68	1063
SEC61A2	-6
SEC11C	-164
SRP9	-225
RPSA	-420
RPN2	-941
RPL26L1	-949
RPL36AL	-2092
SEC61G	-2298
RPS27L	-2397
SRP72	-2411
SRP14	-2710
SPCS2	-2815
RPL39L	-2911
SRP54	-3296
SRPRA	-3572
SPCS1	-4276
RPS28	-4755
RPLP2	-4796
RPN1	-5291
SSR2	-5294
SEC61A1	-5862
SSR4	-5869

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	127
set	Cap-dependent Translation Initiation
setSize	115
pANOVA	2.62e-18
s.dist	0.471
p.adjustANOVA	2.44e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
EIF3M	6006
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
EIF2S3	5156
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
EIF2B2	4805
RPL35A	4700
EIF4A1	4517
RPS20	4323
EIF3D	4212
RPL18A	4115
RPS12	4048
EIF3E	3912
RPS5	3813
EIF2S2	3756
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
EIF3A	3092
UBA52	2829
EIF4B	2587
RPS29	2299
RPLP0	2239
RPL14	2227
EIF3F	2186
RPS17	2073
RPL22L1	1964
RPS26	1750
EIF3L	1225
FAU	1155
EIF2S1	1072
EIF3G	978
EIF3J	849
RPSA	-420
EIF3K	-591
EIF3H	-785
RPL26L1	-949
EIF2B1	-1578
EIF2B5	-1650
EIF3B	-1725
EIF4E	-1791
EIF5B	-1945
RPL36AL	-2092
EIF5	-2378
RPS27L	-2397
EIF4G1	-2493
EIF2B4	-2683
RPL39L	-2911
PABPC1	-3146
EIF3C	-3245
EIF2B3	-3730
EIF1AX	-4390
RPS28	-4755
RPLP2	-4796
EIF4H	-5641
EIF3I	-6241
EIF4EBP1	-6838

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	321
set	Eukaryotic Translation Initiation
setSize	115
pANOVA	2.62e-18
s.dist	0.471
p.adjustANOVA	2.44e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
EIF4A2	7196
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
EIF3M	6006
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
EIF2S3	5156
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
EIF2B2	4805
RPL35A	4700
EIF4A1	4517
RPS20	4323
EIF3D	4212
RPL18A	4115
RPS12	4048
EIF3E	3912
RPS5	3813
EIF2S2	3756
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
EIF3A	3092
UBA52	2829
EIF4B	2587
RPS29	2299
RPLP0	2239
RPL14	2227
EIF3F	2186
RPS17	2073
RPL22L1	1964
RPS26	1750
EIF3L	1225
FAU	1155
EIF2S1	1072
EIF3G	978
EIF3J	849
RPSA	-420
EIF3K	-591
EIF3H	-785
RPL26L1	-949
EIF2B1	-1578
EIF2B5	-1650
EIF3B	-1725
EIF4E	-1791
EIF5B	-1945
RPL36AL	-2092
EIF5	-2378
RPS27L	-2397
EIF4G1	-2493
EIF2B4	-2683
RPL39L	-2911
PABPC1	-3146
EIF3C	-3245
EIF2B3	-3730
EIF1AX	-4390
RPS28	-4755
RPLP2	-4796
EIF4H	-5641
EIF3I	-6241
EIF4EBP1	-6838

---

Early Phase of HIV Life Cycle

Early Phase of HIV Life Cycle

	306
set	Early Phase of HIV Life Cycle
setSize	12
pANOVA	0.00477
s.dist	-0.471
p.adjustANOVA	0.0262

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KPNA1	-7954
XRCC5	-7246
BANF1	-6818
PPIA	-6813
CXCR4	-5734
HMGA1	-5337
FEN1	-4586
PSIP1	-2933
LIG1	-2042
XRCC6	-1566
LIG4	211
XRCC4	3865

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KPNA1	-7954
XRCC5	-7246
BANF1	-6818
PPIA	-6813
CXCR4	-5734
HMGA1	-5337
FEN1	-4586
PSIP1	-2933
LIG1	-2042
XRCC6	-1566
LIG4	211
XRCC4	3865

---

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Inhibition of replication initiation of damaged DNA by RB1/E2F1

	491
set	Inhibition of replication initiation of damaged DNA by RB1/E2F1
setSize	12
pANOVA	0.00498
s.dist	-0.468
p.adjustANOVA	0.0268

Top enriched genes

Top 20 genes

GeneID	Gene Rank
E2F1	-7730
PRIM2	-7036
POLA2	-6956
TFDP2	-5549
PPP2R1A	-4878
PPP2CB	-4738
PPP2CA	-4611
RB1	-4096
TFDP1	-3849
POLA1	-2924
PRIM1	-1099
PPP2R1B	6736

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
E2F1	-7730
PRIM2	-7036
POLA2	-6956
TFDP2	-5549
PPP2R1A	-4878
PPP2CB	-4738
PPP2CA	-4611
RB1	-4096
TFDP1	-3849
POLA1	-2924
PRIM1	-1099
PPP2R1B	6736

---

Interleukin-7 signaling

Interleukin-7 signaling

	527
set	Interleukin-7 signaling
setSize	17
pANOVA	0.000895
s.dist	0.465
p.adjustANOVA	0.00843

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL7	7633
PIK3R1	7617
SOCS2	7581
STAT3	7512
SOCS1	7501
STAT5A	7092
IRS1	6127
TSLP	5482
JAK1	5149
PIK3R3	3619
IRS2	2726
CISH	1877
BRWD1	685
IL7R	-140
STAT5B	-1159
RAG1	-2134
SMARCA4	-6668

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL7	7633
PIK3R1	7617
SOCS2	7581
STAT3	7512
SOCS1	7501
STAT5A	7092
IRS1	6127
TSLP	5482
JAK1	5149
PIK3R3	3619
IRS2	2726
CISH	1877
BRWD1	685
IL7R	-140
STAT5B	-1159
RAG1	-2134
SMARCA4	-6668

---

MicroRNA (miRNA) biogenesis

MicroRNA (miRNA) biogenesis

	611
set	MicroRNA (miRNA) biogenesis
setSize	23
pANOVA	0.00012
s.dist	-0.463
p.adjustANOVA	0.00198

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKRA	-7621
AGO3	-7491
POLR2B	-7299
POLR2C	-6952
XPO5	-6861
AGO2	-6706
POLR2L	-6552
DICER1	-6184
POLR2A	-5502
POLR2I	-5220
POLR2J	-4515
POLR2D	-3686
AGO1	-3601
DROSHA	-3282
DGCR8	-3176
BCDIN3D	-3063
POLR2E	-2326
POLR2H	-2271
TARBP2	-2252
RAN	-2132

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKRA	-7621
AGO3	-7491
POLR2B	-7299
POLR2C	-6952
XPO5	-6861
AGO2	-6706
POLR2L	-6552
DICER1	-6184
POLR2A	-5502
POLR2I	-5220
POLR2J	-4515
POLR2D	-3686
AGO1	-3601
DROSHA	-3282
DGCR8	-3176
BCDIN3D	-3063
POLR2E	-2326
POLR2H	-2271
TARBP2	-2252
RAN	-2132
AGO4	410
POLR2K	1794
POLR2G	5897

---

G beta:gamma signalling through CDC42

G beta:gamma signalling through CDC42

	375
set	G beta:gamma signalling through CDC42
setSize	13
pANOVA	0.00423
s.dist	-0.458
p.adjustANOVA	0.0244

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNB1	-7832
ARHGEF6	-7731
CDC42	-7346
GNG2	-6182
PAK1	-5068
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNB1	-7832
ARHGEF6	-7731
CDC42	-7346
GNG2	-6182
PAK1	-5068
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

---

G-protein beta:gamma signalling

G-protein beta:gamma signalling

	380
set	G-protein beta:gamma signalling
setSize	20
pANOVA	0.000405
s.dist	-0.457
p.adjustANOVA	0.00496

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIK3CG	-8121
GNB1	-7832
ARHGEF6	-7731
RHOA	-7560
CDC42	-7346
GNG2	-6182
AKT1	-5885
PAK1	-5068
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
AKT2	-3273
PDPK1	-1474
PLCB2	-254
PLCB3	119
GNB2	190
GNG4	2080
GNB4	2633

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIK3CG	-8121
GNB1	-7832
ARHGEF6	-7731
RHOA	-7560
CDC42	-7346
GNG2	-6182
AKT1	-5885
PAK1	-5068
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
AKT2	-3273
PDPK1	-1474
PLCB2	-254
PLCB3	119
GNB2	190
GNG4	2080
GNB4	2633

---

Listeria monocytogenes entry into host cells

Listeria monocytogenes entry into host cells

	558
set	Listeria monocytogenes entry into host cells
setSize	19
pANOVA	0.000652
s.dist	-0.452
p.adjustANOVA	0.00683

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MET	-7772
SRC	-7694
CBL	-7686
UBC	-7510
STAM	-7142
SH3KBP1	-6821
HGS	-6028
SH3GL3	-5152
GRB2	-5151
SH3GL1	-5098
CTNND1	-4669
CTNNB1	-4351
STAM2	-4166
CBLL1	-2513
EPS15	-775
SH3GL2	1067
UBB	2232
UBA52	2829
RPS27A	4934

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MET	-7772
SRC	-7694
CBL	-7686
UBC	-7510
STAM	-7142
SH3KBP1	-6821
HGS	-6028
SH3GL3	-5152
GRB2	-5151
SH3GL1	-5098
CTNND1	-4669
CTNNB1	-4351
STAM2	-4166
CBLL1	-2513
EPS15	-775
SH3GL2	1067
UBB	2232
UBA52	2829
RPS27A	4934

---

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

	923
set	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
setSize	13
pANOVA	0.00484
s.dist	-0.451
p.adjustANOVA	0.0263

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RBPJ	-7836
MAML3	-7770
ONECUT3	-6500
KAT2B	-5524
MAMLD1	-4145
EP300	-4071
MAML1	-3725
MAML2	-3503
NOTCH1	-3443
SNW1	-3026
CREBBP	-1636
KAT2A	-1025
HES1	3338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RBPJ	-7836
MAML3	-7770
ONECUT3	-6500
KAT2B	-5524
MAMLD1	-4145
EP300	-4071
MAML1	-3725
MAML2	-3503
NOTCH1	-3443
SNW1	-3026
CREBBP	-1636
KAT2A	-1025
HES1	3338

---

G beta:gamma signalling through PI3Kgamma

G beta:gamma signalling through PI3Kgamma

	376
set	G beta:gamma signalling through PI3Kgamma
setSize	15
pANOVA	0.00278
s.dist	-0.446
p.adjustANOVA	0.0179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIK3CG	-8121
GNB1	-7832
RHOA	-7560
GNG2	-6182
AKT1	-5885
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
AKT2	-3273
PDPK1	-1474
GNB2	190
GNG4	2080
GNB4	2633

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIK3CG	-8121
GNB1	-7832
RHOA	-7560
GNG2	-6182
AKT1	-5885
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
AKT2	-3273
PDPK1	-1474
GNB2	190
GNG4	2080
GNB4	2633

---

CRMPs in Sema3A signaling

CRMPs in Sema3A signaling

	119
set	CRMPs in Sema3A signaling
setSize	14
pANOVA	0.00387
s.dist	-0.446
p.adjustANOVA	0.0232

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GSK3B	-7750
PLXNA2	-7469
DPYSL5	-6593
NRP1	-6126
SEMA3A	-5796
PLXNA3	-5021
CDK5R1	-4814
DPYSL3	-4087
CDK5	-1831
DPYSL4	-1491
FYN	-928
PLXNA4	-751
DPYSL2	176
PLXNA1	461

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GSK3B	-7750
PLXNA2	-7469
DPYSL5	-6593
NRP1	-6126
SEMA3A	-5796
PLXNA3	-5021
CDK5R1	-4814
DPYSL3	-4087
CDK5	-1831
DPYSL4	-1491
FYN	-928
PLXNA4	-751
DPYSL2	176
PLXNA1	461

---

Post-chaperonin tubulin folding pathway

Post-chaperonin tubulin folding pathway

	782
set	Post-chaperonin tubulin folding pathway
setSize	15
pANOVA	0.00294
s.dist	-0.444
p.adjustANOVA	0.0186

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBB6	-7684
TUBA1B	-7630
TUBB4B	-7275
TUBA1A	-7206
TUBA1C	-6246
ARL2	-5839
TUBA4A	-5753
TUBB3	-3595
TUBB2A	-3212
TBCC	-3148
TBCD	-2492
TUBB2B	-1552
TBCE	1383
TBCA	1475
TBCB	3327

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBB6	-7684
TUBA1B	-7630
TUBB4B	-7275
TUBA1A	-7206
TUBA1C	-6246
ARL2	-5839
TUBA4A	-5753
TUBB3	-3595
TUBB2A	-3212
TBCC	-3148
TBCD	-2492
TUBB2B	-1552
TBCE	1383
TBCA	1475
TBCB	3327

---

Growth hormone receptor signaling

Growth hormone receptor signaling

	436
set	Growth hormone receptor signaling
setSize	19
pANOVA	0.000989
s.dist	0.436
p.adjustANOVA	0.00897

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JAK2	7829
SOCS3	7610
SOCS2	7581
STAT3	7512
SOCS1	7501
PRLR	7396
STAT5A	7092
GHR	6518
IRS1	6127
ADAM17	5433
STAT1	3403
LYN	3308
IRS2	2726
CISH	1877
SH2B1	-873
STAT5B	-1159
MAPK3	-1487
PTPN1	-7258
MAPK1	-7898

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JAK2	7829
SOCS3	7610
SOCS2	7581
STAT3	7512
SOCS1	7501
PRLR	7396
STAT5A	7092
GHR	6518
IRS1	6127
ADAM17	5433
STAT1	3403
LYN	3308
IRS2	2726
CISH	1877
SH2B1	-873
STAT5B	-1159
MAPK3	-1487
PTPN1	-7258
MAPK1	-7898

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	694
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	111
pANOVA	2.87e-15
s.dist	0.434
p.adjustANOVA	2.33e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
UPF3B	6030
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
MAGOH	4551
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UPF3A	3001
UPF2	2989
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
GSPT1	2038
RPL22L1	1964
RPS26	1750
PNRC2	1666
FAU	1155
EIF4A3	1055
RBM8A	619
SMG8	191
ETF1	-382
RPSA	-420
RNPS1	-731
RPL26L1	-949
MAGOHB	-1455
SMG5	-1693
NCBP2	-2083
RPL36AL	-2092
RPS27L	-2397
EIF4G1	-2493
RPL39L	-2911
GSPT2	-2915
PABPC1	-3146
SMG1	-3382
SMG9	-3764
NCBP1	-3996
PPP2CA	-4611
RPS28	-4755
RPLP2	-4796
PPP2R1A	-4878
UPF1	-4980
SMG6	-5010
CASC3	-5018
PPP2R2A	-5145
DCP1A	-5628
SMG7	-7083

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	696
set	Nonsense-Mediated Decay (NMD)
setSize	111
pANOVA	2.87e-15
s.dist	0.434
p.adjustANOVA	2.33e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3	7709
RPL36A	7564
RPL5	7546
RPS4X	7545
RPL11	7506
RPL35	7491
RPL13	7482
RPL37A	7469
RPL12	7451
RPS8	7346
RPL37	7299
RPL21	7288
RPL10A	7263
RPL8	7250
RPS6	7142
RPL3	7084
RPL41	7005
RPL7	6994
RPL13A	6981
RPS10	6958
RPL23	6955
RPL27	6873
RPS7	6848
RPL6	6714
RPL15	6711
RPL18	6682
RPL26	6620
RPL31	6576
RPS24	6550
RPL22	6484
RPL23A	6456
RPL19	6446
RPS14	6423
RPL34	6142
RPL38	6116
RPL36	6094
UPF3B	6030
RPS11	5993
RPS15	5978
RPL32	5962
RPL27A	5942
RPS21	5904
RPS16	5868
RPLP1	5853
RPS3A	5838
RPS25	5817
RPL29	5699
RPS15A	5641
RPL10	5601
RPL17	5565
RPL4	5548
RPL30	5499
RPL9	5491
RPL7A	5345
RPL28	5153
RPL24	5002
RPS19	4957
RPS27A	4934
RPS23	4925
RPL39	4832
RPL35A	4700
MAGOH	4551
RPS20	4323
RPL18A	4115
RPS12	4048
RPS5	3813
RPS2	3733
RPS27	3395
RPS9	3266
RPS13	3116
UPF3A	3001
UPF2	2989
UBA52	2829
RPS29	2299
RPLP0	2239
RPL14	2227
RPS17	2073
GSPT1	2038
RPL22L1	1964
RPS26	1750
PNRC2	1666
FAU	1155
EIF4A3	1055
RBM8A	619
SMG8	191
ETF1	-382
RPSA	-420
RNPS1	-731
RPL26L1	-949
MAGOHB	-1455
SMG5	-1693
NCBP2	-2083
RPL36AL	-2092
RPS27L	-2397
EIF4G1	-2493
RPL39L	-2911
GSPT2	-2915
PABPC1	-3146
SMG1	-3382
SMG9	-3764
NCBP1	-3996
PPP2CA	-4611
RPS28	-4755
RPLP2	-4796
PPP2R1A	-4878
UPF1	-4980
SMG6	-5010
CASC3	-5018
PPP2R2A	-5145
DCP1A	-5628
SMG7	-7083

---

Activation of G protein gated Potassium channels

Activation of G protein gated Potassium channels

	33
set	Activation of G protein gated Potassium channels
setSize	13
pANOVA	0.00678
s.dist	-0.434
p.adjustANOVA	0.0327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNB1	-7832
KCNJ12	-6805
GNG2	-6182
GABBR2	-5685
KCNJ2	-5104
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNB1	-7832
KCNJ12	-6805
GNG2	-6182
GABBR2	-5685
KCNJ2	-5104
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

---

G protein gated Potassium channels

G protein gated Potassium channels

	378
set	G protein gated Potassium channels
setSize	13
pANOVA	0.00678
s.dist	-0.434
p.adjustANOVA	0.0327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNB1	-7832
KCNJ12	-6805
GNG2	-6182
GABBR2	-5685
KCNJ2	-5104
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNB1	-7832
KCNJ12	-6805
GNG2	-6182
GABBR2	-5685
KCNJ2	-5104
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

---

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

	489
set	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
setSize	13
pANOVA	0.00678
s.dist	-0.434
p.adjustANOVA	0.0327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNB1	-7832
KCNJ12	-6805
GNG2	-6182
GABBR2	-5685
KCNJ2	-5104
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNB1	-7832
KCNJ12	-6805
GNG2	-6182
GABBR2	-5685
KCNJ2	-5104
GNG5	-4990
GNG11	-4466
GNB5	-3927
GNG12	-3607
GNB3	-3342
GNB2	190
GNG4	2080
GNB4	2633

---

Regulation of IFNA signaling

Regulation of IFNA signaling

	897
set	Regulation of IFNA signaling
setSize	11
pANOVA	0.0131
s.dist	0.432
p.adjustANOVA	0.0531

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SOCS3	7610
IFNAR2	7587
SOCS1	7501
JAK1	5149
USP18	4998
IFNAR1	4326
STAT1	3403
STAT2	2532
PTPN11	435
TYK2	-53
PTPN1	-7258

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SOCS3	7610
IFNAR2	7587
SOCS1	7501
JAK1	5149
USP18	4998
IFNAR1	4326
STAT1	3403
STAT2	2532
PTPN11	435
TYK2	-53
PTPN1	-7258

---

Notch-HLH transcription pathway

Notch-HLH transcription pathway

	698
set	Notch-HLH transcription pathway
setSize	25
pANOVA	0.000212
s.dist	-0.428
p.adjustANOVA	0.00293

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RBPJ	-7836
MAML3	-7770
HDAC8	-7426
HDAC1	-7409
HDAC5	-6907
HDAC7	-6800
NOTCH2	-6323
HDAC9	-6283
HDAC2	-6053
HDAC6	-5702
KAT2B	-5524
HDAC3	-5428
NCOR2	-4774
MAMLD1	-4145
MAML1	-3725
MAML2	-3503
NOTCH1	-3443
SNW1	-3026
NCOR1	-2380
CREBBP	-1636

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RBPJ	-7836
MAML3	-7770
HDAC8	-7426
HDAC1	-7409
HDAC5	-6907
HDAC7	-6800
NOTCH2	-6323
HDAC9	-6283
HDAC2	-6053
HDAC6	-5702
KAT2B	-5524
HDAC3	-5428
NCOR2	-4774
MAMLD1	-4145
MAML1	-3725
MAML2	-3503
NOTCH1	-3443
SNW1	-3026
NCOR1	-2380
CREBBP	-1636
KAT2A	-1025
TBL1X	3314
HDAC11	3495
TBL1XR1	4631
HDAC4	6421

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

	317
set	Establishment of Sister Chromatid Cohesion
setSize	11
pANOVA	0.0142
s.dist	-0.427
p.adjustANOVA	0.0556

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ESCO1	-7099
STAG2	-6231
CDCA5	-6025
WAPL	-5377
RAD21	-4630
STAG1	-3389
PDS5A	-2850
SMC3	-2842
SMC1A	-1818
ESCO2	-480
PDS5B	1524

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ESCO1	-7099
STAG2	-6231
CDCA5	-6025
WAPL	-5377
RAD21	-4630
STAG1	-3389
PDS5A	-2850
SMC3	-2842
SMC1A	-1818
ESCO2	-480
PDS5B	1524

---

Gluconeogenesis

Gluconeogenesis

	417
set	Gluconeogenesis
setSize	25
pANOVA	0.000233
s.dist	-0.425
p.adjustANOVA	0.00319

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC37A2	-8071
GOT2	-7808
ENO2	-6707
SLC25A10	-6670
PC	-6582
SLC25A13	-6521
SLC37A4	-6501
MDH2	-6461
G6PC3	-6380
SLC25A11	-6368
PGAM1	-6092
GOT1	-5415
SLC25A1	-5135
GAPDH	-4566
GPI	-3774
PCK2	-2249
TPI1	-1874
SLC25A12	-1695
ENO3	-636
ALDOA	-80

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC37A2	-8071
GOT2	-7808
ENO2	-6707
SLC25A10	-6670
PC	-6582
SLC25A13	-6521
SLC37A4	-6501
MDH2	-6461
G6PC3	-6380
SLC25A11	-6368
PGAM1	-6092
GOT1	-5415
SLC25A1	-5135
GAPDH	-4566
GPI	-3774
PCK2	-2249
TPI1	-1874
SLC25A12	-1695
ENO3	-636
ALDOA	-80
ALDOC	49
MDH1	635
ENO1	1892
PGK1	2282
SLC37A1	6027

---

Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Synthesis of active ubiquitin: roles of E1 and E2 enzymes

	1120
set	Synthesis of active ubiquitin: roles of E1 and E2 enzymes
setSize	30
pANOVA	5.71e-05
s.dist	-0.425
p.adjustANOVA	0.00102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2A	-8137
UBE2D1	-8102
UBE2G1	-7862
OTULIN	-7633
UBC	-7510
UBE2Z	-7449
UBE2R2	-7310
UBE2E3	-7018
UBE2E1	-6943
UCHL3	-6826
UBE2D2	-6675
UBA1	-6440
UBE2K	-6204
USP9X	-6141
UBE2S	-5666
USP5	-5395
UBE2C	-5051
UBE2B	-4444
CDC34	-4394
UBE2Q2	-3054

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2A	-8137
UBE2D1	-8102
UBE2G1	-7862
OTULIN	-7633
UBC	-7510
UBE2Z	-7449
UBE2R2	-7310
UBE2E3	-7018
UBE2E1	-6943
UCHL3	-6826
UBE2D2	-6675
UBA1	-6440
UBE2K	-6204
USP9X	-6141
UBE2S	-5666
USP5	-5395
UBE2C	-5051
UBE2B	-4444
CDC34	-4394
UBE2Q2	-3054
UBE2W	-2430
UBE2L3	-1481
USP7	540
UBE2H	2039
UBB	2232
UBE2T	2461
UBA52	2829
RPS27A	4934
UBA6	4968
UBE2G2	5910

---

Suppression of phagosomal maturation

Suppression of phagosomal maturation

	1103
set	Suppression of phagosomal maturation
setSize	12
pANOVA	0.0121
s.dist	-0.418
p.adjustANOVA	0.0513

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAB5A	-8050
KPNA1	-7954
UBC	-7510
RAB7A	-6858
HGS	-6028
KPNB1	-5789
CORO1A	-4642
ATP6V1H	-2658
VPS33B	-2436
UBB	2232
UBA52	2829
RPS27A	4934

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAB5A	-8050
KPNA1	-7954
UBC	-7510
RAB7A	-6858
HGS	-6028
KPNB1	-5789
CORO1A	-4642
ATP6V1H	-2658
VPS33B	-2436
UBB	2232
UBA52	2829
RPS27A	4934

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] reshape2_1.4.4              beeswarm_0.2.3             
##  [5] gtools_3.8.2                echarts4r_0.3.3            
##  [7] vioplot_0.3.5               zoo_1.8-8                  
##  [9] sm_2.2-5.6                  mitch_1.2.2                
## [11] gplots_3.1.0                fgsea_1.16.0               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.57.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] forcats_0.5.0               stringr_1.4.0              
## [25] dplyr_1.0.2                 purrr_0.3.4                
## [27] readr_1.4.0                 tidyr_1.1.2                
## [29] tibble_3.0.4                ggplot2_3.3.2              
## [31] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.12       
##  [7] bit64_4.0.5            AnnotationDbi_1.52.0   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.3         
## [13] geneplotter_1.68.0     knitr_1.30             jsonlite_1.7.1        
## [16] broom_0.7.2            annotate_1.68.0        dbplyr_2.0.0          
## [19] shiny_1.5.0            compiler_4.0.3         httr_1.4.2            
## [22] backports_1.2.0        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.1.0              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.3            gtable_0.3.0          
## [31] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
## [34] Rcpp_1.0.5             cellranger_1.1.0       vctrs_0.3.4           
## [37] xfun_0.19              ps_1.4.0               testthat_3.0.0        
## [40] rvest_0.3.6            mime_0.9               lifecycle_0.2.0       
## [43] XML_3.99-0.5           zlibbioc_1.36.0        MASS_7.3-53           
## [46] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [49] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [52] gridExtra_2.3          reshape_0.8.8          stringi_1.5.3         
## [55] RSQLite_2.2.1          highr_0.8              genefilter_1.72.0     
## [58] desc_1.2.0             caTools_1.18.0         BiocParallel_1.24.1   
## [61] rlang_0.4.8            pkgconfig_2.0.3        bitops_1.0-6          
## [64] evaluate_0.14          lattice_0.20-41        htmlwidgets_1.5.2     
## [67] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
## [70] magrittr_1.5           R6_2.5.0               generics_0.1.0        
## [73] DelayedArray_0.16.0    DBI_1.1.0              pillar_1.4.6          
## [76] haven_2.3.1            withr_2.3.0            survival_3.2-7        
## [79] RCurl_1.98-1.2         modelr_0.1.8           crayon_1.3.4          
## [82] KernSmooth_2.23-18     rmarkdown_2.5          locfit_1.5-9.4        
## [85] grid_4.0.3             readxl_1.3.1           data.table_1.13.2     
## [88] blob_1.2.1             reprex_0.3.0           digest_0.6.27         
## [91] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0         
## [94] tcltk_4.0.3

END of report