date generated: 2025-03-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -1.0773226
A1BG 0.3336187
A1BG-AS1 0.2776715
A2M -12.2154486
A2M-AS1 -3.3886041
A4GALT -3.2991663

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2734
num_genes_in_profile 19545
duplicated_genes_present 0
num_profile_genes_in_sets 8425
num_profile_genes_not_in_sets 11120

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2734
num_genesets_excluded 1209
num_genesets_included 1525

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
HDR through MMEJ (alt-NHEJ) 12 1.96e-04 0.621 2.20e-03
Complex III assembly 25 1.70e-07 0.604 6.63e-06
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 5.78e-04 -0.599 4.90e-03
TNFs bind their physiological receptors 15 6.74e-05 -0.594 9.10e-04
TP53 Regulates Transcription of Death Receptors and Ligands 11 6.83e-04 -0.591 5.37e-03
Dissolution of Fibrin Clot 11 1.01e-03 -0.573 6.94e-03
Regulated proteolysis of p75NTR 11 1.36e-03 -0.558 8.93e-03
Plasma lipoprotein remodeling 16 1.28e-04 -0.553 1.57e-03
Endosomal/Vacuolar pathway 11 1.52e-03 -0.552 9.79e-03
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.95e-05 0.545 6.05e-04
Chondroitin sulfate biosynthesis 18 6.91e-05 -0.542 9.17e-04
Phase 4 - resting membrane potential 13 9.08e-04 -0.531 6.51e-03
Formation of ATP by chemiosmotic coupling 20 6.92e-05 0.514 9.17e-04
Cristae formation 33 3.49e-07 0.512 1.26e-05
TGFBR3 PTM regulation 11 3.58e-03 -0.507 1.78e-02
Complex I biogenesis 66 1.31e-12 0.505 1.34e-10
Mitochondrial RNA degradation 25 1.65e-05 0.498 3.14e-04
The canonical retinoid cycle in rods (twilight vision) 12 3.18e-03 -0.492 1.65e-02
Killing mechanisms 11 4.75e-03 -0.492 2.12e-02
WNT5:FZD7-mediated leishmania damping 11 4.75e-03 -0.492 2.12e-02
Specification of primordial germ cells 10 7.23e-03 -0.491 2.87e-02
Maturation of nucleoprotein 9683610 11 4.88e-03 -0.490 2.16e-02
Cytosolic tRNA aminoacylation 24 3.37e-05 0.489 5.29e-04
CS/DS degradation 12 3.37e-03 -0.489 1.70e-02
Nucleotide biosynthesis 12 3.46e-03 0.487 1.74e-02
Glycosphingolipid biosynthesis 18 5.94e-04 -0.468 4.97e-03
WNT ligand biogenesis and trafficking 19 4.92e-04 -0.462 4.39e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 10 1.20e-02 -0.459 4.28e-02
Termination of O-glycan biosynthesis 12 6.40e-03 -0.455 2.60e-02
AKT phosphorylates targets in the nucleus 10 1.35e-02 -0.451 4.73e-02
Attachment and Entry 9694614 16 1.82e-03 -0.450 1.12e-02
Citric acid cycle (TCA cycle) 33 7.88e-06 0.449 1.82e-04
Cellular hexose transport 12 7.12e-03 -0.449 2.86e-02
Signalling to RAS 19 7.45e-04 -0.447 5.60e-03
Respiratory electron transport 151 3.29e-21 0.445 1.67e-18
N-glycan antennae elongation in the medial/trans-Golgi 20 6.30e-04 -0.441 5.08e-03
Glyoxylate metabolism and glycine degradation 11 1.14e-02 0.441 4.11e-02
SARS-CoV-1 modulates host translation machinery 35 6.70e-06 -0.440 1.57e-04
rRNA processing in the mitochondrion 27 7.94e-05 0.439 1.04e-03
Lysine catabolism 12 9.16e-03 0.434 3.45e-02
NOTCH2 intracellular domain regulates transcription 10 1.81e-02 -0.432 5.84e-02
Regulation of localization of FOXO transcription factors 12 1.00e-02 -0.429 3.70e-02
WNT5A-dependent internalization of FZD4 15 4.36e-03 0.425 2.01e-02
p38MAPK events 13 7.96e-03 -0.425 3.10e-02
Diseases of DNA repair 51 1.50e-07 0.425 6.03e-06
SHC-mediated cascade:FGFR1 13 8.16e-03 -0.424 3.14e-02
MET activates RAP1 and RAC1 10 2.15e-02 -0.420 6.71e-02
CLEC7A (Dectin-1) induces NFAT activation 11 1.67e-02 -0.417 5.53e-02
Signalling to ERKs 32 4.60e-05 -0.416 6.61e-04
Chemokine receptors bind chemokines 15 5.30e-03 -0.416 2.27e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
HDR through MMEJ (alt-NHEJ) 12 1.96e-04 0.621000 2.20e-03
Complex III assembly 25 1.70e-07 0.604000 6.63e-06
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 5.78e-04 -0.599000 4.90e-03
TNFs bind their physiological receptors 15 6.74e-05 -0.594000 9.10e-04
TP53 Regulates Transcription of Death Receptors and Ligands 11 6.83e-04 -0.591000 5.37e-03
Dissolution of Fibrin Clot 11 1.01e-03 -0.573000 6.94e-03
Regulated proteolysis of p75NTR 11 1.36e-03 -0.558000 8.93e-03
Plasma lipoprotein remodeling 16 1.28e-04 -0.553000 1.57e-03
Endosomal/Vacuolar pathway 11 1.52e-03 -0.552000 9.79e-03
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.95e-05 0.545000 6.05e-04
Chondroitin sulfate biosynthesis 18 6.91e-05 -0.542000 9.17e-04
Phase 4 - resting membrane potential 13 9.08e-04 -0.531000 6.51e-03
Formation of ATP by chemiosmotic coupling 20 6.92e-05 0.514000 9.17e-04
Cristae formation 33 3.49e-07 0.512000 1.26e-05
TGFBR3 PTM regulation 11 3.58e-03 -0.507000 1.78e-02
Complex I biogenesis 66 1.31e-12 0.505000 1.34e-10
Mitochondrial RNA degradation 25 1.65e-05 0.498000 3.14e-04
The canonical retinoid cycle in rods (twilight vision) 12 3.18e-03 -0.492000 1.65e-02
Killing mechanisms 11 4.75e-03 -0.492000 2.12e-02
WNT5:FZD7-mediated leishmania damping 11 4.75e-03 -0.492000 2.12e-02
Specification of primordial germ cells 10 7.23e-03 -0.491000 2.87e-02
Maturation of nucleoprotein 9683610 11 4.88e-03 -0.490000 2.16e-02
Cytosolic tRNA aminoacylation 24 3.37e-05 0.489000 5.29e-04
CS/DS degradation 12 3.37e-03 -0.489000 1.70e-02
Nucleotide biosynthesis 12 3.46e-03 0.487000 1.74e-02
Glycosphingolipid biosynthesis 18 5.94e-04 -0.468000 4.97e-03
WNT ligand biogenesis and trafficking 19 4.92e-04 -0.462000 4.39e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 10 1.20e-02 -0.459000 4.28e-02
Termination of O-glycan biosynthesis 12 6.40e-03 -0.455000 2.60e-02
AKT phosphorylates targets in the nucleus 10 1.35e-02 -0.451000 4.73e-02
Attachment and Entry 9694614 16 1.82e-03 -0.450000 1.12e-02
Citric acid cycle (TCA cycle) 33 7.88e-06 0.449000 1.82e-04
Cellular hexose transport 12 7.12e-03 -0.449000 2.86e-02
Signalling to RAS 19 7.45e-04 -0.447000 5.60e-03
Respiratory electron transport 151 3.29e-21 0.445000 1.67e-18
N-glycan antennae elongation in the medial/trans-Golgi 20 6.30e-04 -0.441000 5.08e-03
Glyoxylate metabolism and glycine degradation 11 1.14e-02 0.441000 4.11e-02
SARS-CoV-1 modulates host translation machinery 35 6.70e-06 -0.440000 1.57e-04
rRNA processing in the mitochondrion 27 7.94e-05 0.439000 1.04e-03
Lysine catabolism 12 9.16e-03 0.434000 3.45e-02
NOTCH2 intracellular domain regulates transcription 10 1.81e-02 -0.432000 5.84e-02
Regulation of localization of FOXO transcription factors 12 1.00e-02 -0.429000 3.70e-02
WNT5A-dependent internalization of FZD4 15 4.36e-03 0.425000 2.01e-02
p38MAPK events 13 7.96e-03 -0.425000 3.10e-02
Diseases of DNA repair 51 1.50e-07 0.425000 6.03e-06
SHC-mediated cascade:FGFR1 13 8.16e-03 -0.424000 3.14e-02
MET activates RAP1 and RAC1 10 2.15e-02 -0.420000 6.71e-02
CLEC7A (Dectin-1) induces NFAT activation 11 1.67e-02 -0.417000 5.53e-02
Signalling to ERKs 32 4.60e-05 -0.416000 6.61e-04
Chemokine receptors bind chemokines 15 5.30e-03 -0.416000 2.27e-02
Caspase activation via Death Receptors in the presence of ligand 14 7.09e-03 -0.416000 2.85e-02
Ion homeostasis 40 6.01e-06 -0.414000 1.48e-04
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 2.01e-04 0.413000 2.24e-03
Defective B3GAT3 causes JDSSDHD 17 3.22e-03 -0.413000 1.66e-02
Protein lipoylation 10 2.39e-02 0.412000 7.26e-02
Strand-asynchronous mitochondrial DNA replication 10 2.41e-02 0.412000 7.29e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 3.29e-03 -0.412000 1.68e-02
NOTCH4 Intracellular Domain Regulates Transcription 19 1.91e-03 -0.411000 1.12e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 5.19e-06 0.411000 1.30e-04
Diseases of DNA Double-Strand Break Repair 41 5.19e-06 0.411000 1.30e-04
Crosslinking of collagen fibrils 15 5.87e-03 -0.411000 2.43e-02
N-Glycan antennae elongation 12 1.37e-02 -0.411000 4.75e-02
Lewis blood group biosynthesis 12 1.38e-02 -0.410000 4.75e-02
Homologous DNA Pairing and Strand Exchange 43 3.49e-06 0.409000 9.68e-05
Presynaptic phase of homologous DNA pairing and strand exchange 40 8.03e-06 0.408000 1.83e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 4.30e-04 0.407000 4.04e-03
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 4.30e-04 0.407000 4.04e-03
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 4.30e-04 0.407000 4.04e-03
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 4.30e-04 0.407000 4.04e-03
tRNA Aminoacylation 42 5.17e-06 0.406000 1.30e-04
Gap junction assembly 20 1.83e-03 -0.403000 1.12e-02
Transport of connexons to the plasma membrane 14 9.40e-03 -0.401000 3.51e-02
Repression of WNT target genes 14 9.45e-03 -0.401000 3.52e-02
Formation of the cornified envelope 37 2.56e-05 -0.400000 4.38e-04
Impaired BRCA2 binding to PALB2 24 7.00e-04 0.400000 5.41e-03
Induction of Cell-Cell Fusion 10 2.92e-02 -0.398000 8.47e-02
Impaired BRCA2 binding to RAD51 35 4.92e-05 0.396000 7.01e-04
SHC-mediated cascade:FGFR2 14 1.02e-02 -0.396000 3.76e-02
Defective B4GALT7 causes EDS, progeroid type 17 5.00e-03 -0.393000 2.19e-02
Keratan sulfate biosynthesis 21 1.89e-03 -0.392000 1.12e-02
Caspase activation via extrinsic apoptotic signalling pathway 24 9.09e-04 -0.391000 6.51e-03
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.17e-02 -0.389000 4.19e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.17e-02 -0.389000 4.19e-02
Mitochondrial protein degradation 95 8.46e-11 0.385000 6.14e-09
Interleukin-10 signaling 28 4.40e-04 -0.384000 4.06e-03
Nephrin family interactions 18 4.83e-03 -0.384000 2.15e-02
Elastic fibre formation 37 6.11e-05 -0.381000 8.32e-04
Caspase-mediated cleavage of cytoskeletal proteins 12 2.27e-02 -0.380000 6.99e-02
Postmitotic nuclear pore complex (NPC) reformation 27 6.40e-04 0.380000 5.12e-03
CD209 (DC-SIGN) signaling 18 5.33e-03 -0.379000 2.27e-02
FCERI mediated Ca+2 mobilization 27 7.20e-04 -0.376000 5.46e-03
Ephrin signaling 19 4.56e-03 -0.376000 2.07e-02
Acyl chain remodelling of PS 12 2.42e-02 -0.376000 7.32e-02
Post-translational protein phosphorylation 75 2.04e-08 -0.375000 1.07e-06
FOXO-mediated transcription of cell cycle genes 15 1.21e-02 -0.374000 4.33e-02
DAP12 interactions 28 6.22e-04 -0.374000 5.04e-03
Signaling by NOTCH2 33 2.04e-04 -0.374000 2.26e-03
Specification of the neural plate border 12 2.54e-02 -0.373000 7.59e-02
Activated NOTCH1 Transmits Signal to the Nucleus 28 6.42e-04 -0.373000 5.12e-03
Elevation of cytosolic Ca2+ levels 10 4.20e-02 -0.371000 1.10e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 2.05e-02 -0.371000 6.47e-02
Rap1 signalling 15 1.35e-02 -0.368000 4.73e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination 24 1.80e-03 -0.368000 1.11e-02
Interleukin-15 signaling 13 2.20e-02 -0.367000 6.84e-02
Aerobic respiration and respiratory electron transport 243 7.06e-23 0.367000 5.38e-20
Platelet calcium homeostasis 21 3.65e-03 -0.366000 1.80e-02
Keratinization 38 9.64e-05 -0.366000 1.21e-03
mRNA Capping 29 6.56e-04 0.366000 5.19e-03
Resolution of D-Loop Structures 36 1.47e-04 0.366000 1.75e-03
RNA Pol II CTD phosphorylation and interaction with CE 27 1.03e-03 0.365000 7.07e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.03e-03 0.365000 7.07e-03
tRNA processing in the mitochondrion 30 5.69e-04 0.364000 4.85e-03
Defects in cobalamin (B12) metabolism 13 2.36e-02 -0.363000 7.22e-02
Erythropoietin activates RAS 12 2.97e-02 -0.362000 8.60e-02
Reduction of cytosolic Ca++ levels 11 3.79e-02 -0.362000 1.02e-01
Germ layer formation at gastrulation 12 3.02e-02 -0.361000 8.69e-02
Respiratory syncytial virus (RSV) attachment and entry 21 4.23e-03 -0.361000 1.97e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 83 1.48e-08 -0.360000 8.08e-07
Amine ligand-binding receptors 18 8.30e-03 -0.359000 3.17e-02
Prolonged ERK activation events 13 2.50e-02 -0.359000 7.48e-02
Voltage gated Potassium channels 29 8.46e-04 -0.358000 6.17e-03
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 14 2.09e-02 -0.357000 6.53e-02
Caspase activation via Dependence Receptors in the absence of ligand 10 5.10e-02 -0.356000 1.25e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 35 2.70e-04 0.356000 2.79e-03
Formation of TC-NER Pre-Incision Complex 51 1.17e-05 0.355000 2.45e-04
Regulation of beta-cell development 29 9.54e-04 -0.354000 6.64e-03
Formation of the ureteric bud 20 6.09e-03 -0.354000 2.49e-02
Activation of ATR in response to replication stress 37 1.94e-04 0.354000 2.19e-03
Deadenylation of mRNA 22 4.12e-03 0.353000 1.95e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 24 2.75e-03 -0.353000 1.48e-02
SHC-mediated cascade:FGFR3 12 3.43e-02 -0.353000 9.63e-02
NCAM1 interactions 36 2.52e-04 -0.352000 2.63e-03
NF-kB is activated and signals survival 12 3.51e-02 -0.351000 9.76e-02
cGMP effects 11 4.37e-02 -0.351000 1.13e-01
Chondroitin sulfate/dermatan sulfate metabolism 48 2.69e-05 -0.350000 4.56e-04
HDR through Single Strand Annealing (SSA) 37 2.31e-04 0.350000 2.48e-03
Interferon alpha/beta signaling 61 2.34e-06 -0.350000 6.86e-05
p75NTR signals via NF-kB 15 1.91e-02 -0.349000 6.11e-02
NCAM signaling for neurite out-growth 56 6.28e-06 -0.349000 1.52e-04
Presynaptic depolarization and calcium channel opening 10 5.63e-02 -0.349000 1.34e-01
RHO GTPases activate IQGAPs 24 3.15e-03 -0.348000 1.64e-02
NRIF signals cell death from the nucleus 15 1.98e-02 -0.348000 6.29e-02
Activation of BAD and translocation to mitochondria 15 2.01e-02 -0.347000 6.40e-02
Transport of vitamins, nucleosides, and related molecules 31 8.40e-04 -0.347000 6.17e-03
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 2.48e-02 -0.346000 7.45e-02
Acyl chain remodelling of PE 17 1.36e-02 -0.346000 4.74e-02
Nuclear import of Rev protein 34 5.06e-04 0.345000 4.49e-03
Complement cascade 23 4.33e-03 -0.344000 2.01e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 1.74e-02 0.343000 5.73e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 56 9.30e-06 -0.342000 2.00e-04
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 4.53e-03 -0.342000 2.07e-02
SHC-mediated cascade:FGFR4 12 4.04e-02 -0.342000 1.08e-01
Laminin interactions 29 1.47e-03 -0.341000 9.61e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 2.72e-02 0.341000 8.03e-02
mRNA decay by 3’ to 5’ exoribonuclease 16 1.84e-02 0.340000 5.93e-02
Vpr-mediated nuclear import of PICs 34 6.04e-04 0.340000 4.97e-03
Frs2-mediated activation 11 5.14e-02 -0.339000 1.26e-01
Tight junction interactions 14 2.82e-02 -0.339000 8.28e-02
Mismatch Repair 15 2.34e-02 0.338000 7.18e-02
EPHA-mediated growth cone collapse 25 3.47e-03 -0.338000 1.74e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 3.63e-07 0.337000 1.26e-05
TICAM1-dependent activation of IRF3/IRF7 13 3.61e-02 -0.336000 9.98e-02
Regulation of Complement cascade 20 9.56e-03 -0.335000 3.55e-02
IL-6-type cytokine receptor ligand interactions 14 3.01e-02 -0.335000 8.69e-02
Cholesterol biosynthesis 26 3.20e-03 -0.334000 1.66e-02
Collagen chain trimerization 34 7.60e-04 -0.334000 5.68e-03
RUNX2 regulates osteoblast differentiation 21 8.41e-03 -0.332000 3.21e-02
Mitochondrial protein import 64 4.36e-06 0.332000 1.17e-04
Interactions of Rev with host cellular proteins 37 4.80e-04 0.332000 4.30e-03
Mitochondrial tRNA aminoacylation 21 8.58e-03 0.331000 3.26e-02
AKT phosphorylates targets in the cytosol 14 3.22e-02 -0.331000 9.20e-02
Formation of the dystrophin-glycoprotein complex (DGC) 29 2.08e-03 -0.330000 1.21e-02
Cardiac conduction 95 2.86e-08 -0.329000 1.41e-06
DAP12 signaling 23 6.43e-03 -0.328000 2.61e-02
Mitochondrial translation elongation 90 7.40e-08 0.328000 3.32e-06
Activation of BH3-only proteins 29 2.22e-03 -0.328000 1.27e-02
Formation of annular gap junctions 11 5.97e-02 0.328000 1.40e-01
Mitochondrial translation 96 2.99e-08 0.327000 1.42e-06
Class B/2 (Secretin family receptors) 59 1.43e-05 -0.327000 2.87e-04
Glycogen synthesis 13 4.16e-02 -0.326000 1.10e-01
RA biosynthesis pathway 16 2.38e-02 -0.326000 7.23e-02
Pyroptosis 22 8.09e-03 -0.326000 3.13e-02
Nephron development 10 7.42e-02 -0.326000 1.65e-01
Eukaryotic Translation Elongation 91 7.81e-08 -0.326000 3.40e-06
Role of LAT2/NTAL/LAB on calcium mobilization 14 3.51e-02 -0.325000 9.76e-02
O-linked glycosylation of mucins 39 4.47e-04 -0.325000 4.08e-03
Regulation of gene expression in beta cells 13 4.30e-02 -0.324000 1.12e-01
Maturation of nucleoprotein 9694631 15 3.00e-02 -0.324000 8.66e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.55e-03 0.323000 9.86e-03
Mitochondrial translation initiation 90 1.16e-07 0.323000 4.77e-06
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 3.63e-02 -0.323000 1.00e-01
Lagging Strand Synthesis 20 1.27e-02 0.322000 4.50e-02
Peptide chain elongation 86 2.61e-07 -0.321000 9.94e-06
Potassium Channels 70 3.45e-06 -0.321000 9.68e-05
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 3.77e-02 0.321000 1.02e-01
Initial triggering of complement 11 6.61e-02 -0.320000 1.51e-01
Keratan sulfate/keratin metabolism 29 2.90e-03 -0.320000 1.55e-02
ECM proteoglycans 59 2.19e-05 -0.319000 3.97e-04
Blood group systems biosynthesis 15 3.24e-02 -0.319000 9.23e-02
Collagen formation 77 1.41e-06 -0.318000 4.31e-05
Neurexins and neuroligins 45 2.27e-04 -0.318000 2.48e-03
Resolution of Abasic Sites (AP sites) 38 7.07e-04 0.318000 5.41e-03
HDR through Homologous Recombination (HRR) 69 5.11e-06 0.317000 1.30e-04
Extracellular matrix organization 242 1.89e-17 -0.317000 4.12e-15
Alpha-protein kinase 1 signaling pathway 11 7.01e-02 -0.315000 1.58e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 2.06e-02 -0.315000 6.47e-02
Maturation of TCA enzymes and regulation of TCA cycle 20 1.50e-02 0.314000 5.07e-02
MyD88 deficiency (TLR2/4) 10 8.55e-02 -0.314000 1.85e-01
Amyloid fiber formation 49 1.44e-04 -0.314000 1.73e-03
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 4.35e-04 0.314000 4.04e-03
HIV Transcription Elongation 42 4.35e-04 0.314000 4.04e-03
Tat-mediated elongation of the HIV-1 transcript 42 4.35e-04 0.314000 4.04e-03
Mitochondrial translation termination 90 2.77e-07 0.313000 1.03e-05
Assembly of collagen fibrils and other multimeric structures 53 8.58e-05 -0.312000 1.10e-03
HS-GAG biosynthesis 24 8.24e-03 -0.312000 3.16e-02
Peptide ligand-binding receptors 70 6.60e-06 -0.311000 1.57e-04
Transport of bile salts and organic acids, metal ions and amine compounds 48 1.92e-04 -0.311000 2.18e-03
Gap-filling DNA repair synthesis and ligation in TC-NER 62 2.28e-05 0.311000 4.08e-04
Molecules associated with elastic fibres 30 3.24e-03 -0.311000 1.66e-02
Retinoid metabolism and transport 28 4.49e-03 -0.310000 2.06e-02
Heme biosynthesis 12 6.29e-02 0.310000 1.45e-01
Interactions of Vpr with host cellular proteins 37 1.11e-03 0.310000 7.49e-03
Diseases of branched-chain amino acid catabolism 13 5.31e-02 0.310000 1.29e-01
RUNX2 regulates bone development 27 5.34e-03 -0.310000 2.27e-02
NS1 Mediated Effects on Host Pathways 40 7.09e-04 0.309000 5.41e-03
DARPP-32 events 23 1.03e-02 -0.309000 3.79e-02
FCERI mediated MAPK activation 29 4.05e-03 -0.308000 1.92e-02
Collagen biosynthesis and modifying enzymes 55 7.69e-05 -0.308000 1.01e-03
Biotin transport and metabolism 11 7.75e-02 0.307000 1.71e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 2.63e-03 0.307000 1.42e-02
Collagen degradation 51 1.48e-04 -0.307000 1.75e-03
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 9.27e-02 0.307000 1.94e-01
Formation of the Early Elongation Complex 33 2.36e-03 0.306000 1.30e-02
Formation of the HIV-1 Early Elongation Complex 33 2.36e-03 0.306000 1.30e-02
Cytosolic iron-sulfur cluster assembly 13 5.63e-02 0.306000 1.34e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 4.55e-04 0.305000 4.13e-03
Deactivation of the beta-catenin transactivating complex 41 7.33e-04 -0.305000 5.53e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 4.12e-02 -0.304000 1.09e-01
Rev-mediated nuclear export of HIV RNA 35 1.89e-03 0.303000 1.12e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 9.66e-02 -0.303000 2.00e-01
Translation of Structural Proteins 9683701 29 4.72e-03 -0.303000 2.12e-02
Nitric oxide stimulates guanylate cyclase 14 4.97e-02 -0.303000 1.23e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 6.96e-04 0.302000 5.41e-03
Viral mRNA Translation 86 1.29e-06 -0.302000 4.10e-05
TP53 Regulates Transcription of Cell Death Genes 39 1.11e-03 -0.302000 7.49e-03
Selenocysteine synthesis 90 7.88e-07 -0.301000 2.61e-05
Viral Messenger RNA Synthesis 44 5.48e-04 0.301000 4.80e-03
Integrin cell surface interactions 64 3.11e-05 -0.301000 4.99e-04
RHOBTB1 GTPase cycle 23 1.25e-02 0.301000 4.44e-02
Signaling by NODAL 14 5.23e-02 -0.300000 1.27e-01
Branched-chain amino acid catabolism 21 1.81e-02 0.298000 5.84e-02
IRAK2 mediated activation of TAK1 complex 10 1.04e-01 -0.297000 2.11e-01
Transport of the SLBP independent Mature mRNA 35 2.38e-03 0.297000 1.30e-02
IRAK4 deficiency (TLR2/4) 11 8.84e-02 -0.297000 1.88e-01
Regulation of insulin secretion 62 5.54e-05 -0.296000 7.76e-04
Formation of WDR5-containing histone-modifying complexes 42 9.15e-04 0.296000 6.52e-03
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 8.97e-02 -0.296000 1.91e-01
SHC1 events in EGFR signaling 11 8.99e-02 -0.295000 1.91e-01
Intrinsic Pathway of Fibrin Clot Formation 11 8.99e-02 -0.295000 1.91e-01
FOXO-mediated transcription of cell death genes 15 4.77e-02 -0.295000 1.20e-01
Activation of the pre-replicative complex 33 3.33e-03 0.295000 1.69e-02
NGF-stimulated transcription 36 2.19e-03 -0.295000 1.25e-02
FRS-mediated FGFR1 signaling 15 4.83e-02 -0.295000 1.20e-01
Signaling by NTRK3 (TRKC) 16 4.17e-02 -0.294000 1.10e-01
rRNA modification in the nucleus and cytosol 60 8.64e-05 0.293000 1.10e-03
Kidney development 40 1.36e-03 -0.293000 8.92e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.14e-02 0.292000 4.13e-02
RHO GTPases Activate NADPH Oxidases 17 3.72e-02 -0.292000 1.01e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 9.29e-04 0.292000 6.59e-03
Removal of the Flap Intermediate 14 6.02e-02 0.290000 1.41e-01
Processive synthesis on the lagging strand 15 5.17e-02 0.290000 1.26e-01
Activation of RAC1 13 7.22e-02 -0.288000 1.61e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.51e-03 -0.288000 2.30e-02
Surfactant metabolism 14 6.37e-02 -0.286000 1.46e-01
Nuclear Events (kinase and transcription factor activation) 58 1.67e-04 -0.286000 1.96e-03
TRAF6 mediated IRF7 activation 16 4.79e-02 -0.286000 1.20e-01
Complex IV assembly 44 1.06e-03 0.285000 7.22e-03
Export of Viral Ribonucleoproteins from Nucleus 33 4.58e-03 0.285000 2.07e-02
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 16 4.88e-02 -0.285000 1.21e-01
Transport of the SLBP Dependant Mature mRNA 36 3.16e-03 0.284000 1.65e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 12 8.82e-02 -0.284000 1.88e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 4.34e-02 0.283000 1.12e-01
SLBP independent Processing of Histone Pre-mRNAs 10 1.22e-01 0.283000 2.39e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 98 1.34e-06 -0.283000 4.18e-05
Ion transport by P-type ATPases 38 2.61e-03 -0.282000 1.41e-02
mRNA Splicing - Major Pathway 202 4.82e-12 0.282000 4.60e-10
Deadenylation-dependent mRNA decay 53 3.91e-04 0.282000 3.87e-03
HS-GAG degradation 22 2.25e-02 -0.281000 6.96e-02
GPVI-mediated activation cascade 26 1.33e-02 -0.280000 4.68e-02
Eukaryotic Translation Termination 90 4.26e-06 -0.280000 1.16e-04
RNA Polymerase III Abortive And Retractive Initiation 41 1.90e-03 0.280000 1.12e-02
RNA Polymerase III Transcription 41 1.90e-03 0.280000 1.12e-02
TRAF3-dependent IRF activation pathway 14 6.95e-02 -0.280000 1.57e-01
Dual incision in TC-NER 63 1.22e-04 0.280000 1.49e-03
IGF1R signaling cascade 40 2.25e-03 -0.279000 1.27e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 40 2.25e-03 -0.279000 1.27e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 4.29e-05 0.279000 6.41e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 7.22e-03 0.279000 2.87e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 7.22e-03 0.279000 2.87e-02
FRS-mediated FGFR2 signaling 16 5.37e-02 -0.279000 1.30e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.76e-04 0.278000 2.03e-03
Transport of Mature Transcript to Cytoplasm 81 1.58e-05 0.277000 3.05e-04
Regulated Necrosis 50 6.91e-04 -0.277000 5.40e-03
Regulation of TP53 Activity through Association with Co-factors 12 9.67e-02 -0.277000 2.00e-01
Gluconeogenesis 16 5.57e-02 -0.276000 1.33e-01
Triglyceride catabolism 16 5.63e-02 -0.276000 1.34e-01
mRNA Splicing 210 5.99e-12 0.275000 5.37e-10
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 8.61e-02 -0.275000 1.86e-01
Defective EXT2 causes exostoses 2 13 8.61e-02 -0.275000 1.86e-01
Synthesis of PIPs at the late endosome membrane 11 1.15e-01 0.274000 2.30e-01
CRMPs in Sema3A signaling 16 5.79e-02 -0.274000 1.36e-01
tRNA processing 134 4.52e-08 0.274000 2.09e-06
Metabolism of fat-soluble vitamins 32 7.48e-03 -0.273000 2.94e-02
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 4.49e-02 -0.273000 1.15e-01
G alpha (i) signalling events 167 1.20e-09 -0.273000 7.31e-08
DNA strand elongation 32 7.61e-03 0.273000 2.98e-02
Regulation of TLR by endogenous ligand 10 1.36e-01 -0.273000 2.61e-01
SARS-CoV-1-host interactions 90 8.31e-06 -0.272000 1.84e-04
ABC transporters in lipid homeostasis 12 1.03e-01 -0.272000 2.10e-01
Generation of second messenger molecules 20 3.57e-02 -0.271000 9.89e-02
Adenylate cyclase inhibitory pathway 12 1.04e-01 -0.271000 2.11e-01
Processing of Capped Intron-Containing Pre-mRNA 278 8.20e-15 0.271000 1.14e-12
Leading Strand Synthesis 14 7.98e-02 0.270000 1.74e-01
Polymerase switching 14 7.98e-02 0.270000 1.74e-01
Metabolism of porphyrins 19 4.13e-02 0.270000 1.09e-01
FGFR1 ligand binding and activation 10 1.39e-01 -0.270000 2.65e-01
SUMOylation of DNA methylation proteins 16 6.15e-02 -0.270000 1.43e-01
Cell surface interactions at the vascular wall 86 1.51e-05 -0.270000 2.95e-04
MET promotes cell motility 38 3.98e-03 -0.270000 1.90e-02
Interleukin-4 and Interleukin-13 signaling 82 2.42e-05 -0.270000 4.28e-04
RAS processing 22 2.90e-02 -0.269000 8.44e-02
ER Quality Control Compartment (ERQC) 21 3.30e-02 -0.269000 9.34e-02
Constitutive Signaling by AKT1 E17K in Cancer 26 1.78e-02 -0.269000 5.79e-02
Signaling by NOTCH3 44 2.06e-03 -0.269000 1.20e-02
MicroRNA (miRNA) biogenesis 24 2.28e-02 0.268000 7.02e-02
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 1.24e-01 -0.268000 2.42e-01
Nuclear signaling by ERBB4 26 1.81e-02 -0.268000 5.84e-02
Regulation of signaling by CBL 19 4.36e-02 -0.267000 1.13e-01
Acyl chain remodelling of PC 17 5.67e-02 -0.267000 1.34e-01
Retrograde neurotrophin signalling 13 9.58e-02 0.267000 1.99e-01
tRNA processing in the nucleus 59 4.20e-04 0.265000 4.04e-03
RNA Polymerase III Transcription Termination 23 2.76e-02 0.265000 8.10e-02
Interleukin-2 family signaling 29 1.36e-02 -0.265000 4.73e-02
Sema4D induced cell migration and growth-cone collapse 20 4.06e-02 -0.264000 1.08e-01
Biosynthesis of DHA-derived SPMs 11 1.30e-01 -0.264000 2.52e-01
Biosynthesis of specialized proresolving mediators (SPMs) 12 1.14e-01 -0.263000 2.28e-01
IRS-related events triggered by IGF1R 39 4.44e-03 -0.263000 2.04e-02
PCNA-Dependent Long Patch Base Excision Repair 21 3.70e-02 0.263000 1.01e-01
Formation of RNA Pol II elongation complex 57 6.06e-04 0.263000 4.97e-03
RNA Polymerase II Transcription Elongation 57 6.06e-04 0.263000 4.97e-03
Signaling by GPCR 401 1.86e-19 -0.263000 7.07e-17
Metabolism of non-coding RNA 53 9.50e-04 0.262000 6.64e-03
snRNP Assembly 53 9.50e-04 0.262000 6.64e-03
Signaling by ERBB4 47 1.90e-03 -0.262000 1.12e-02
Other semaphorin interactions 15 7.96e-02 -0.261000 1.74e-01
p75NTR recruits signalling complexes 12 1.17e-01 -0.261000 2.32e-01
Plasma lipoprotein assembly, remodeling, and clearance 52 1.14e-03 -0.261000 7.65e-03
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 5.56e-02 -0.261000 1.33e-01
SUMOylation of SUMOylation proteins 35 7.62e-03 0.261000 2.98e-02
Ubiquinol biosynthesis 13 1.04e-01 0.261000 2.11e-01
Insulin receptor signalling cascade 42 3.49e-03 -0.260000 1.74e-02
ERK/MAPK targets 22 3.47e-02 -0.260000 9.68e-02
Pausing and recovery of Tat-mediated HIV elongation 30 1.38e-02 0.260000 4.75e-02
Tat-mediated HIV elongation arrest and recovery 30 1.38e-02 0.260000 4.75e-02
Non-integrin membrane-ECM interactions 66 2.65e-04 -0.260000 2.75e-03
Plasma lipoprotein assembly 11 1.36e-01 -0.259000 2.61e-01
Activation of the TFAP2 (AP-2) family of transcription factors 10 1.56e-01 -0.259000 2.89e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 92 1.85e-05 -0.258000 3.45e-04
Cell recruitment (pro-inflammatory response) 22 3.66e-02 -0.257000 1.01e-01
Purinergic signaling in leishmaniasis infection 22 3.66e-02 -0.257000 1.01e-01
Muscle contraction 143 1.11e-07 -0.257000 4.69e-06
FOXO-mediated transcription 56 8.75e-04 -0.257000 6.35e-03
GPCR ligand binding 200 3.69e-10 -0.257000 2.45e-08
Diseases associated with glycosaminoglycan metabolism 32 1.21e-02 -0.256000 4.31e-02
FGFR2 ligand binding and activation 10 1.61e-01 -0.256000 2.93e-01
SARS-CoV-1 Infection 134 3.54e-07 -0.255000 1.26e-05
SARS-CoV-2 modulates host translation machinery 48 2.30e-03 -0.254000 1.28e-02
GPCR downstream signalling 359 1.54e-16 -0.254000 2.93e-14
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 1.05e-02 -0.254000 3.84e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 25 2.87e-02 -0.253000 8.40e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 35 9.80e-03 -0.252000 3.63e-02
HIV elongation arrest and recovery 32 1.37e-02 0.252000 4.75e-02
Pausing and recovery of HIV elongation 32 1.37e-02 0.252000 4.75e-02
Diseases associated with the TLR signaling cascade 23 3.68e-02 -0.251000 1.01e-01
Diseases of Immune System 23 3.68e-02 -0.251000 1.01e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 1.69e-01 -0.251000 3.01e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 1.04e-01 -0.251000 2.11e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 4.70e-02 0.250000 1.19e-01
Signaling by FLT3 fusion proteins 19 5.91e-02 -0.250000 1.39e-01
tRNA modification in the nucleus and cytosol 43 4.57e-03 0.250000 2.07e-02
Netrin-1 signaling 38 7.68e-03 -0.250000 3.00e-02
SARS-CoV-2 modulates autophagy 11 1.52e-01 0.250000 2.83e-01
Interleukin-6 family signaling 21 4.83e-02 -0.249000 1.20e-01
Folding of actin by CCT/TriC 10 1.74e-01 0.248000 3.07e-01
Formation of axial mesoderm 11 1.54e-01 -0.248000 2.87e-01
Platelet degranulation 92 4.39e-05 -0.246000 6.50e-04
Gap-filling DNA repair synthesis and ligation in GG-NER 25 3.32e-02 0.246000 9.39e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 8.83e-02 -0.246000 1.88e-01
mRNA Splicing - Minor Pathway 50 2.62e-03 0.246000 1.41e-02
Class A/1 (Rhodopsin-like receptors) 132 1.10e-06 -0.246000 3.57e-05
Formation of the nephric duct 15 1.00e-01 -0.245000 2.06e-01
Homology Directed Repair 111 8.25e-06 0.245000 1.84e-04
Formation of a pool of free 40S subunits 98 2.82e-05 -0.245000 4.71e-04
Degradation of the extracellular matrix 102 1.95e-05 -0.245000 3.57e-04
EPH-ephrin mediated repulsion of cells 47 3.78e-03 -0.244000 1.84e-02
G alpha (s) signalling events 94 4.47e-05 -0.244000 6.55e-04
Interleukin receptor SHC signaling 17 8.21e-02 -0.244000 1.78e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23 4.33e-02 -0.243000 1.12e-01
Downstream signaling of activated FGFR1 23 4.34e-02 -0.243000 1.12e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.63e-01 0.243000 2.95e-01
RUNX3 regulates NOTCH signaling 14 1.16e-01 -0.243000 2.30e-01
Nucleotide salvage 20 6.18e-02 -0.241000 1.43e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 56 1.90e-03 -0.240000 1.12e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 56 1.90e-03 -0.240000 1.12e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 56 1.90e-03 -0.240000 1.12e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 56 1.90e-03 -0.240000 1.12e-02
Signaling by NOTCH1 in Cancer 56 1.90e-03 -0.240000 1.12e-02
mRNA 3’-end processing 57 1.73e-03 0.240000 1.09e-02
Formation of Fibrin Clot (Clotting Cascade) 17 8.69e-02 -0.240000 1.87e-01
HIV Transcription Initiation 45 5.38e-03 0.240000 2.27e-02
RNA Polymerase II HIV Promoter Escape 45 5.38e-03 0.240000 2.27e-02
RNA Polymerase II Promoter Escape 45 5.38e-03 0.240000 2.27e-02
RNA Polymerase II Transcription Initiation 45 5.38e-03 0.240000 2.27e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 5.38e-03 0.240000 2.27e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 5.38e-03 0.240000 2.27e-02
Sema4D in semaphorin signaling 24 4.20e-02 -0.240000 1.10e-01
Interleukin-7 signaling 20 6.36e-02 -0.240000 1.46e-01
Metal ion SLC transporters 20 6.36e-02 -0.240000 1.46e-01
G alpha (z) signalling events 39 9.72e-03 -0.239000 3.60e-02
Signaling by LTK 10 1.90e-01 -0.239000 3.26e-01
Nucleotide Excision Repair 108 1.81e-05 0.239000 3.40e-04
RIPK1-mediated regulated necrosis 28 2.90e-02 -0.238000 8.44e-02
Regulation of necroptotic cell death 28 2.90e-02 -0.238000 8.44e-02
Fertilization 10 1.92e-01 -0.238000 3.28e-01
Response to elevated platelet cytosolic Ca2+ 97 5.02e-05 -0.238000 7.08e-04
Processing of Intronless Pre-mRNAs 20 6.53e-02 0.238000 1.50e-01
Vitamin D (calciferol) metabolism 11 1.72e-01 -0.238000 3.05e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 4.86e-02 0.238000 1.21e-01
Transcription of the HIV genome 67 7.78e-04 0.237000 5.78e-03
Early Phase of HIV Life Cycle 12 1.55e-01 0.237000 2.87e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 4.46e-02 -0.237000 1.15e-01
Signaling by NOTCH1 70 6.16e-04 -0.237000 5.02e-03
RNA Polymerase II Transcription Termination 66 8.93e-04 0.236000 6.45e-03
Early SARS-CoV-2 Infection Events 34 1.71e-02 -0.236000 5.63e-02
Metabolism of steroid hormones 23 4.98e-02 -0.236000 1.23e-01
Glycosaminoglycan metabolism 107 2.44e-05 -0.236000 4.28e-04
Activation of Matrix Metalloproteinases 21 6.13e-02 -0.236000 1.43e-01
Transcriptional regulation of granulopoiesis 43 7.47e-03 -0.236000 2.94e-02
RHOBTB GTPase Cycle 35 1.58e-02 0.236000 5.27e-02
Glycosphingolipid metabolism 51 3.61e-03 -0.236000 1.79e-02
GRB2 events in EGFR signaling 10 1.97e-01 -0.236000 3.34e-01
Downstream signaling of activated FGFR2 21 6.17e-02 -0.236000 1.43e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 3.11e-02 0.235000 8.91e-02
O-linked glycosylation 82 2.33e-04 -0.235000 2.48e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.03e-01 -0.235000 2.10e-01
Platelet activation, signaling and aggregation 199 1.13e-08 -0.235000 6.35e-07
Intrinsic Pathway for Apoptosis 51 3.86e-03 -0.234000 1.86e-02
Activation of the AP-1 family of transcription factors 10 2.01e-01 -0.234000 3.38e-01
Regulation of IFNA/IFNB signaling 11 1.80e-01 0.234000 3.14e-01
Signaling by PDGF 54 3.02e-03 -0.233000 1.59e-02
Diseases associated with O-glycosylation of proteins 51 3.97e-03 -0.233000 1.90e-02
RNA Polymerase I Transcription Initiation 47 5.69e-03 0.233000 2.36e-02
ZBP1(DAI) mediated induction of type I IFNs 18 8.81e-02 -0.232000 1.88e-01
Gap junction degradation 12 1.64e-01 0.232000 2.97e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 105 4.20e-05 0.231000 6.34e-04
Processing of Capped Intronless Pre-mRNA 29 3.16e-02 0.231000 9.04e-02
IRS-mediated signalling 37 1.54e-02 -0.230000 5.16e-02
Signaling by NTRK1 (TRKA) 110 3.05e-05 -0.230000 4.95e-04
Growth hormone receptor signaling 19 8.27e-02 -0.230000 1.79e-01
Anti-inflammatory response favouring Leishmania parasite infection 59 2.26e-03 -0.230000 1.27e-02
Leishmania parasite growth and survival 59 2.26e-03 -0.230000 1.27e-02
PI3K/AKT Signaling in Cancer 85 2.50e-04 -0.230000 2.63e-03
Neuronal System 300 7.74e-12 -0.230000 6.56e-10
Pre-NOTCH Processing in Golgi 17 1.02e-01 -0.229000 2.08e-01
RNA Polymerase III Transcription Initiation 36 1.75e-02 0.229000 5.73e-02
A tetrasaccharide linker sequence is required for GAG synthesis 24 5.23e-02 -0.229000 1.27e-01
Signaling by NTRKs 127 8.98e-06 -0.228000 1.96e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.40e-01 -0.228000 2.66e-01
G alpha (q) signalling events 128 1.04e-05 -0.226000 2.20e-04
Recognition of DNA damage by PCNA-containing replication complex 30 3.26e-02 0.225000 9.26e-02
PKA-mediated phosphorylation of CREB 18 9.82e-02 -0.225000 2.02e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 85 3.43e-04 -0.225000 3.42e-03
Signaling by CSF1 (M-CSF) in myeloid cells 29 3.62e-02 -0.225000 9.99e-02
Processive synthesis on the C-strand of the telomere 19 9.02e-02 0.225000 1.91e-01
FRS-mediated FGFR3 signaling 14 1.46e-01 -0.225000 2.76e-01
Interleukin-12 family signaling 49 6.66e-03 -0.224000 2.69e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 1.10e-01 0.224000 2.21e-01
Activation of GABAB receptors 30 3.39e-02 -0.224000 9.55e-02
GABA B receptor activation 30 3.39e-02 -0.224000 9.55e-02
Glucagon-type ligand receptors 21 7.63e-02 -0.223000 1.69e-01
Peroxisomal lipid metabolism 26 4.88e-02 0.223000 1.21e-01
RHOBTB2 GTPase cycle 23 6.39e-02 0.223000 1.47e-01
Removal of the Flap Intermediate from the C-strand 17 1.11e-01 0.223000 2.23e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 2.69e-02 -0.223000 7.94e-02
RIP-mediated NFkB activation via ZBP1 15 1.36e-01 -0.222000 2.61e-01
Mitochondrial biogenesis 94 2.08e-04 0.221000 2.28e-03
Carnitine shuttle 13 1.67e-01 0.221000 3.00e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.52e-01 -0.221000 2.83e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.68e-01 -0.221000 3.00e-01
Formation of the ternary complex, and subsequently, the 43S complex 50 7.14e-03 -0.220000 2.86e-02
FCGR3A-mediated IL10 synthesis 30 3.75e-02 -0.219000 1.01e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 2.08e-01 0.219000 3.48e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 1.71e-01 0.219000 3.03e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 1.89e-01 -0.219000 3.25e-01
RNA Polymerase II Pre-transcription Events 78 8.43e-04 0.219000 6.17e-03
Mucopolysaccharidoses 11 2.10e-01 -0.218000 3.50e-01
Thrombin signalling through proteinase activated receptors (PARs) 26 5.45e-02 -0.218000 1.31e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 7.15e-02 -0.217000 1.60e-01
Integration of energy metabolism 89 4.04e-04 -0.217000 3.97e-03
NOD1/2 Signaling Pathway 33 3.11e-02 -0.217000 8.91e-02
Miscellaneous transport and binding events 22 7.85e-02 -0.217000 1.73e-01
Leishmania infection 137 1.21e-05 -0.217000 2.46e-04
Parasitic Infection Pathways 137 1.21e-05 -0.217000 2.46e-04
Striated Muscle Contraction 17 1.23e-01 -0.216000 2.40e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 1.94e-01 0.216000 3.31e-01
Negative regulation of the PI3K/AKT network 92 3.38e-04 -0.216000 3.39e-03
p75 NTR receptor-mediated signalling 89 4.43e-04 -0.215000 4.07e-03
Ca2+ pathway 52 7.27e-03 -0.215000 2.88e-02
FRS-mediated FGFR4 signaling 14 1.63e-01 -0.215000 2.96e-01
The activation of arylsulfatases 11 2.17e-01 -0.215000 3.56e-01
RNA Polymerase I Transcription Termination 30 4.18e-02 0.215000 1.10e-01
Sensory processing of sound by inner hair cells of the cochlea 51 8.13e-03 -0.214000 3.13e-02
Interleukin-12 signaling 41 1.76e-02 -0.214000 5.77e-02
SLC-mediated transmembrane transport 163 2.40e-06 -0.214000 6.90e-05
Nuclear Pore Complex (NPC) Disassembly 36 2.63e-02 0.214000 7.78e-02
Thromboxane signalling through TP receptor 20 9.83e-02 -0.214000 2.02e-01
Transcriptional regulation by small RNAs 63 3.50e-03 0.213000 1.74e-02
Processing of DNA double-strand break ends 69 2.30e-03 0.212000 1.28e-02
Inwardly rectifying K+ channels 23 7.87e-02 -0.212000 1.73e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 7.93e-04 0.212000 5.87e-03
Base Excision Repair 59 4.92e-03 0.212000 2.17e-02
Sensory processing of sound by outer hair cells of the cochlea 37 2.61e-02 -0.211000 7.75e-02
Ovarian tumor domain proteases 37 2.61e-02 -0.211000 7.75e-02
Signaling by MET 74 1.68e-03 -0.211000 1.06e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 5.82e-02 0.211000 1.37e-01
Regulation of BACH1 activity 11 2.26e-01 -0.211000 3.69e-01
Synthesis of very long-chain fatty acyl-CoAs 20 1.03e-01 -0.210000 2.10e-01
MAP kinase activation 62 4.20e-03 -0.210000 1.96e-02
Telomere C-strand (Lagging Strand) Synthesis 34 3.44e-02 0.210000 9.63e-02
Opioid Signalling 77 1.49e-03 -0.209000 9.64e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 9.01e-02 -0.209000 1.91e-01
G2/M DNA damage checkpoint 66 3.37e-03 0.209000 1.70e-02
Constitutive Signaling by Aberrant PI3K in Cancer 58 6.08e-03 -0.208000 2.49e-02
Regulation of HSF1-mediated heat shock response 77 1.64e-03 0.208000 1.04e-02
RAF-independent MAPK1/3 activation 23 8.54e-02 -0.207000 1.85e-01
SRP-dependent cotranslational protein targeting to membrane 109 1.88e-04 -0.207000 2.15e-03
RHO GTPases activate CIT 19 1.20e-01 -0.206000 2.35e-01
Meiotic recombination 41 2.25e-02 0.206000 6.96e-02
Interaction between L1 and Ankyrins 23 8.76e-02 -0.206000 1.88e-01
Semaphorin interactions 60 5.88e-03 -0.206000 2.43e-02
DNA Double-Strand Break Repair 141 2.54e-05 0.205000 4.38e-04
Nonhomologous End-Joining (NHEJ) 40 2.48e-02 0.205000 7.45e-02
Protein methylation 15 1.70e-01 0.205000 3.03e-01
Cellular response to heat stress 93 6.56e-04 0.204000 5.19e-03
Dual Incision in GG-NER 41 2.38e-02 0.204000 7.23e-02
Late endosomal microautophagy 30 5.39e-02 -0.203000 1.30e-01
Heparan sulfate/heparin (HS-GAG) metabolism 48 1.50e-02 -0.203000 5.07e-02
Translesion Synthesis by POLH 18 1.37e-01 0.203000 2.61e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 1.00e-01 -0.202000 2.06e-01
PI3K Cascade 33 4.47e-02 -0.202000 1.15e-01
Cell death signalling via NRAGE, NRIF and NADE 69 3.74e-03 -0.202000 1.84e-02
DNA Repair 293 2.84e-09 0.202000 1.66e-07
ERKs are inactivated 13 2.08e-01 -0.202000 3.48e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 109 2.79e-04 -0.201000 2.84e-03
Nuclear Envelope Breakdown 53 1.12e-02 0.201000 4.06e-02
HIV Life Cycle 144 3.05e-05 0.201000 4.95e-04
Nervous system development 508 9.11e-15 -0.201000 1.16e-12
FLT3 Signaling 34 4.27e-02 -0.201000 1.12e-01
Protein-protein interactions at synapses 72 3.30e-03 -0.200000 1.68e-02
Effects of PIP2 hydrolysis 23 9.68e-02 -0.200000 2.00e-01
Neutrophil degranulation 366 5.47e-11 -0.200000 4.17e-09
Interleukin-17 signaling 66 5.11e-03 -0.199000 2.23e-02
Activation of AMPK downstream of NMDARs 21 1.14e-01 -0.199000 2.28e-01
Death Receptor Signaling 143 3.97e-05 -0.199000 6.05e-04
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 101 5.57e-04 -0.199000 4.80e-03
Toll Like Receptor 2 (TLR2) Cascade 101 5.57e-04 -0.199000 4.80e-03
Toll Like Receptor TLR1:TLR2 Cascade 101 5.57e-04 -0.199000 4.80e-03
Toll Like Receptor TLR6:TLR2 Cascade 101 5.57e-04 -0.199000 4.80e-03
Processing of SMDT1 14 1.98e-01 0.199000 3.36e-01
Sphingolipid metabolism 93 9.42e-04 -0.198000 6.64e-03
G-protein activation 17 1.57e-01 -0.198000 2.90e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 98 7.03e-04 -0.198000 5.41e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.25e-01 0.198000 2.44e-01
Platelet homeostasis 64 6.18e-03 -0.198000 2.52e-02
Physiological factors 12 2.36e-01 -0.197000 3.83e-01
Hemostasis 451 7.08e-13 -0.197000 7.71e-11
Late SARS-CoV-2 Infection Events 66 5.58e-03 -0.197000 2.32e-02
Interleukin-35 Signalling 12 2.38e-01 -0.197000 3.84e-01
SUMOylation of transcription factors 18 1.49e-01 -0.196000 2.80e-01
SARS-CoV-1 activates/modulates innate immune responses 37 3.89e-02 -0.196000 1.04e-01
Chaperone Mediated Autophagy 18 1.50e-01 -0.196000 2.80e-01
TNFR1-induced NF-kappa-B signaling pathway 33 5.16e-02 -0.196000 1.26e-01
FLT3 signaling in disease 28 7.34e-02 -0.196000 1.63e-01
G alpha (12/13) signalling events 68 5.33e-03 -0.195000 2.27e-02
RHOU GTPase cycle 40 3.26e-02 -0.195000 9.26e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.76e-01 0.195000 3.10e-01
Regulation of TP53 Activity through Acetylation 29 6.87e-02 0.195000 1.56e-01
PI-3K cascade:FGFR1 13 2.23e-01 -0.195000 3.65e-01
Sialic acid metabolism 29 6.95e-02 -0.195000 1.57e-01
Signal amplification 27 8.02e-02 -0.195000 1.75e-01
Sensory processing of sound 55 1.26e-02 -0.194000 4.47e-02
Late Phase of HIV Life Cycle 133 1.12e-04 0.194000 1.39e-03
Syndecan interactions 25 9.33e-02 -0.194000 1.95e-01
Metabolism of RNA 723 8.11e-19 0.194000 2.47e-16
Cell-Cell communication 112 4.10e-04 -0.193000 4.01e-03
Axon guidance 487 3.03e-13 -0.193000 3.55e-11
RND3 GTPase cycle 39 3.70e-02 -0.193000 1.01e-01
DNA Damage Recognition in GG-NER 38 3.99e-02 0.193000 1.07e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 2.70e-01 -0.192000 4.17e-01
L13a-mediated translational silencing of Ceruloplasmin expression 108 5.69e-04 -0.192000 4.85e-03
Activation of G protein gated Potassium channels 18 1.59e-01 -0.192000 2.91e-01
G protein gated Potassium channels 18 1.59e-01 -0.192000 2.91e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 1.59e-01 -0.192000 2.91e-01
Vitamin B5 (pantothenate) metabolism 18 1.59e-01 0.192000 2.91e-01
Downstream signaling of activated FGFR3 19 1.49e-01 -0.191000 2.80e-01
Pentose phosphate pathway 13 2.33e-01 0.191000 3.79e-01
RHO GTPases activate KTN1 11 2.73e-01 -0.191000 4.19e-01
Extension of Telomeres 51 1.85e-02 0.191000 5.95e-02
Unwinding of DNA 12 2.54e-01 0.190000 4.04e-01
GABA receptor activation 37 4.57e-02 -0.190000 1.16e-01
Formation of definitive endoderm 13 2.36e-01 -0.190000 3.83e-01
SUMOylation of DNA replication proteins 46 2.60e-02 0.190000 7.74e-02
Signaling by Interleukins 350 1.11e-09 -0.190000 7.07e-08
G2/M Checkpoints 126 2.47e-04 0.189000 2.62e-03
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 50 2.07e-02 -0.189000 6.51e-02
MET activates RAS signaling 10 3.01e-01 -0.189000 4.49e-01
G-protein mediated events 48 2.37e-02 -0.189000 7.23e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 1.93e-01 -0.188000 3.29e-01
NRAGE signals death through JNK 52 1.92e-02 -0.188000 6.13e-02
Fanconi Anemia Pathway 35 5.54e-02 0.187000 1.32e-01
MyD88 dependent cascade initiated on endosome 96 1.54e-03 -0.187000 9.86e-03
BBSome-mediated cargo-targeting to cilium 21 1.38e-01 0.187000 2.63e-01
Activation of NMDA receptors and postsynaptic events 77 4.58e-03 -0.187000 2.07e-02
Toll Like Receptor 4 (TLR4) Cascade 125 3.20e-04 -0.186000 3.24e-03
LDL clearance 16 1.97e-01 0.186000 3.34e-01
Negative regulation of MAPK pathway 42 3.71e-02 -0.186000 1.01e-01
Synthesis of bile acids and bile salts 24 1.16e-01 0.186000 2.30e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 1.55e-02 -0.185000 5.20e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.00e-02 0.185000 1.91e-01
Signaling by FGFR3 in disease 16 2.01e-01 -0.185000 3.38e-01
SUMOylation of ubiquitinylation proteins 39 4.61e-02 0.185000 1.17e-01
NFE2L2 regulating tumorigenic genes 10 3.13e-01 -0.184000 4.60e-01
Downstream signaling of activated FGFR4 19 1.65e-01 -0.184000 2.97e-01
PI-3K cascade:FGFR2 14 2.33e-01 -0.184000 3.79e-01
Glycogen metabolism 23 1.27e-01 -0.184000 2.47e-01
Signaling by FGFR2 IIIa TM 19 1.67e-01 0.183000 3.00e-01
Endogenous sterols 17 1.92e-01 -0.183000 3.28e-01
Cell-extracellular matrix interactions 18 1.79e-01 -0.183000 3.14e-01
SHC1 events in ERBB4 signaling 11 2.96e-01 -0.182000 4.44e-01
Cell-cell junction organization 61 1.40e-02 -0.182000 4.80e-02
Toll-like Receptor Cascades 144 1.72e-04 -0.181000 2.01e-03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 95 2.29e-03 -0.181000 1.28e-02
Signaling by FLT3 ITD and TKD mutants 16 2.11e-01 -0.181000 3.50e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 30 8.75e-02 -0.180000 1.88e-01
Regulation of T cell activation by CD28 family 52 2.47e-02 -0.180000 7.44e-02
Cell junction organization 86 3.92e-03 -0.180000 1.89e-02
DNA Replication 141 2.30e-04 0.180000 2.48e-03
COPII-mediated vesicle transport 64 1.30e-02 0.180000 4.57e-02
Establishment of Sister Chromatid Cohesion 11 3.04e-01 0.179000 4.50e-01
Aspirin ADME 13 2.64e-01 -0.179000 4.11e-01
RND1 GTPase cycle 41 4.75e-02 -0.179000 1.20e-01
Platelet Adhesion to exposed collagen 10 3.28e-01 -0.179000 4.75e-01
Regulation of ornithine decarboxylase (ODC) 38 5.71e-02 0.178000 1.35e-01
Gene Silencing by RNA 87 4.04e-03 0.178000 1.92e-02
Stimuli-sensing channels 71 9.98e-03 -0.177000 3.69e-02
Visual phototransduction 58 2.04e-02 -0.176000 6.46e-02
Regulation of FZD by ubiquitination 19 1.84e-01 -0.176000 3.18e-01
Disorders of Developmental Biology 13 2.72e-01 0.176000 4.18e-01
Disorders of Nervous System Development 13 2.72e-01 0.176000 4.18e-01
Loss of function of MECP2 in Rett syndrome 13 2.72e-01 0.176000 4.18e-01
Pervasive developmental disorders 13 2.72e-01 0.176000 4.18e-01
Toll Like Receptor 9 (TLR9) Cascade 102 2.16e-03 -0.176000 1.25e-02
Selenoamino acid metabolism 112 1.33e-03 -0.176000 8.75e-03
Interconversion of nucleotide di- and triphosphates 29 1.02e-01 0.176000 2.08e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 54 2.57e-02 0.176000 7.67e-02
Signaling by Receptor Tyrosine Kinases 466 8.89e-11 -0.175000 6.16e-09
Post NMDA receptor activation events 65 1.47e-02 -0.175000 5.01e-02
Ras activation upon Ca2+ influx through NMDA receptor 17 2.14e-01 -0.174000 3.54e-01
Trafficking and processing of endosomal TLR 10 3.41e-01 -0.174000 4.86e-01
Signaling by TGFBR3 42 5.13e-02 -0.174000 1.26e-01
TRAF6 mediated NF-kB activation 22 1.59e-01 -0.174000 2.91e-01
IRAK1 recruits IKK complex 14 2.62e-01 -0.173000 4.10e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 2.62e-01 -0.173000 4.10e-01
MyD88-independent TLR4 cascade 104 2.38e-03 -0.172000 1.30e-02
TRIF (TICAM1)-mediated TLR4 signaling 104 2.38e-03 -0.172000 1.30e-02
Infection with Mycobacterium tuberculosis 24 1.45e-01 -0.172000 2.74e-01
Transcriptional regulation of pluripotent stem cells 22 1.63e-01 -0.172000 2.95e-01
Synthesis of DNA 108 2.17e-03 0.171000 1.25e-02
Signaling by Erythropoietin 22 1.66e-01 -0.171000 2.99e-01
ADORA2B mediated anti-inflammatory cytokines production 36 7.80e-02 -0.170000 1.72e-01
PLC beta mediated events 44 5.16e-02 -0.170000 1.26e-01
EPH-Ephrin signaling 87 6.29e-03 -0.170000 2.56e-02
Protein localization 155 2.77e-04 0.169000 2.83e-03
Regulation of CDH11 gene transcription 10 3.55e-01 -0.169000 5.01e-01
Ribosomal scanning and start codon recognition 57 2.74e-02 -0.169000 8.08e-02
MyD88 cascade initiated on plasma membrane 91 5.43e-03 -0.169000 2.28e-02
Toll Like Receptor 10 (TLR10) Cascade 91 5.43e-03 -0.169000 2.28e-02
Toll Like Receptor 5 (TLR5) Cascade 91 5.43e-03 -0.169000 2.28e-02
RET signaling 36 8.00e-02 -0.169000 1.75e-01
RHOBTB3 ATPase cycle 10 3.56e-01 0.168000 5.02e-01
Innate Immune System 750 5.08e-15 -0.168000 7.75e-13
TNFR1-induced proapoptotic signaling 25 1.46e-01 -0.168000 2.76e-01
Toll Like Receptor 3 (TLR3) Cascade 100 3.82e-03 -0.167000 1.85e-02
Diseases of glycosylation 117 1.79e-03 -0.167000 1.11e-02
Post-chaperonin tubulin folding pathway 18 2.20e-01 -0.167000 3.61e-01
Transmission across Chemical Synapses 195 5.96e-05 -0.167000 8.19e-04
Ion channel transport 128 1.14e-03 -0.167000 7.63e-03
RNA polymerase II transcribes snRNA genes 71 1.56e-02 0.166000 5.21e-02
HIV Infection 207 3.86e-05 0.166000 6.00e-04
Metabolism of folate and pterines 16 2.51e-01 0.166000 4.00e-01
Platelet Aggregation (Plug Formation) 27 1.37e-01 -0.165000 2.61e-01
PKA activation 16 2.52e-01 -0.165000 4.01e-01
Cellular responses to mechanical stimuli 93 5.97e-03 -0.165000 2.46e-02
Regulation of PTEN mRNA translation 12 3.23e-01 0.165000 4.69e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 5.15e-02 -0.164000 1.26e-01
The NLRP3 inflammasome 13 3.05e-01 -0.164000 4.52e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 10 3.69e-01 -0.164000 5.15e-01
CD28 dependent PI3K/Akt signaling 22 1.85e-01 -0.163000 3.19e-01
GPER1 signaling 38 8.16e-02 -0.163000 1.78e-01
Neurotransmitter release cycle 40 7.45e-02 -0.163000 1.65e-01
Apoptotic cleavage of cellular proteins 33 1.06e-01 -0.163000 2.13e-01
DNA Replication Pre-Initiation 106 3.96e-03 0.162000 1.90e-02
AURKA Activation by TPX2 72 1.77e-02 0.162000 5.77e-02
Metabolism of polyamines 45 6.08e-02 0.162000 1.42e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 21 2.01e-01 -0.161000 3.38e-01
Chromosome Maintenance 105 4.32e-03 0.161000 2.01e-02
Translation of Structural Proteins 9694635 56 3.71e-02 -0.161000 1.01e-01
Notch-HLH transcription pathway 28 1.41e-01 -0.161000 2.68e-01
SUMOylation of immune response proteins 12 3.35e-01 -0.161000 4.81e-01
Loss of Nlp from mitotic centrosomes 69 2.15e-02 0.160000 6.70e-02
Loss of proteins required for interphase microtubule organization from the centrosome 69 2.15e-02 0.160000 6.70e-02
Regulation of TP53 Activity through Phosphorylation 89 9.08e-03 0.160000 3.43e-02
PERK regulates gene expression 32 1.18e-01 0.160000 2.32e-01
Regulation of endogenous retroelements 85 1.09e-02 0.160000 3.96e-02
Cap-dependent Translation Initiation 116 3.01e-03 -0.159000 1.59e-02
Eukaryotic Translation Initiation 116 3.01e-03 -0.159000 1.59e-02
IKK complex recruitment mediated by RIP1 22 1.96e-01 -0.159000 3.33e-01
Signaling by Activin 16 2.70e-01 -0.159000 4.17e-01
Nuclear Receptor transcription pathway 44 6.78e-02 -0.159000 1.54e-01
Host Interactions of HIV factors 111 3.79e-03 0.159000 1.84e-02
Neurotransmitter receptors and postsynaptic signal transmission 144 9.99e-04 -0.159000 6.92e-03
RNA Polymerase III Chain Elongation 18 2.44e-01 0.159000 3.92e-01
Assembly Of The HIV Virion 16 2.72e-01 -0.159000 4.18e-01
Association of TriC/CCT with target proteins during biosynthesis 37 9.51e-02 0.159000 1.99e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 112 3.77e-03 -0.158000 1.84e-02
Nonsense-Mediated Decay (NMD) 112 3.77e-03 -0.158000 1.84e-02
Regulation of FOXO transcriptional activity by acetylation 10 3.86e-01 -0.158000 5.33e-01
Mitochondrial iron-sulfur cluster biogenesis 13 3.23e-01 0.158000 4.69e-01
Signaling by WNT in cancer 32 1.22e-01 -0.158000 2.39e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 2.74e-01 0.158000 4.19e-01
Mitochondrial calcium ion transport 21 2.10e-01 0.158000 3.50e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 17 2.60e-01 -0.158000 4.10e-01
Cytokine Signaling in Immune system 608 3.25e-11 -0.158000 2.61e-09
Synthesis of PE 12 3.45e-01 -0.158000 4.91e-01
Downstream signal transduction 29 1.43e-01 -0.157000 2.71e-01
FGFR2 alternative splicing 25 1.74e-01 0.157000 3.07e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.64e-01 0.157000 4.11e-01
Signaling by FGFR1 44 7.40e-02 -0.156000 1.64e-01
Protein hydroxylation 17 2.68e-01 0.155000 4.15e-01
Signaling by VEGF 98 8.05e-03 -0.155000 3.12e-02
Gap junction trafficking and regulation 33 1.24e-01 -0.155000 2.42e-01
VEGFR2 mediated cell proliferation 19 2.43e-01 -0.155000 3.91e-01
FCGR3A-mediated phagocytosis 52 5.49e-02 -0.154000 1.31e-01
Leishmania phagocytosis 52 5.49e-02 -0.154000 1.31e-01
Parasite infection 52 5.49e-02 -0.154000 1.31e-01
Anchoring of the basal body to the plasma membrane 97 8.83e-03 0.154000 3.34e-02
ATF4 activates genes in response to endoplasmic reticulum stress 27 1.68e-01 0.153000 3.00e-01
Extra-nuclear estrogen signaling 65 3.33e-02 -0.153000 9.41e-02
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.23e-01 0.153000 4.69e-01
Purine salvage 12 3.60e-01 -0.153000 5.07e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 9.54e-02 0.152000 1.99e-01
Nucleosome assembly 40 9.54e-02 0.152000 1.99e-01
Response of endothelial cells to shear stress 84 1.60e-02 -0.152000 5.33e-02
Co-stimulation by CD28 41 9.26e-02 -0.152000 1.94e-01
Signaling by KIT in disease 19 2.53e-01 -0.151000 4.03e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 2.53e-01 -0.151000 4.03e-01
PKA activation in glucagon signalling 15 3.10e-01 -0.151000 4.58e-01
Triglyceride metabolism 23 2.09e-01 -0.151000 3.49e-01
E2F mediated regulation of DNA replication 22 2.20e-01 0.151000 3.61e-01
Regulation of TNFR1 signaling 48 7.03e-02 -0.151000 1.58e-01
Apoptotic factor-mediated response 18 2.68e-01 -0.151000 4.15e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 15 3.14e-01 0.150000 4.62e-01
MAPK1/MAPK3 signaling 226 1.05e-04 -0.150000 1.32e-03
Signal Transduction 2061 7.68e-29 -0.150000 1.17e-25
Tryptophan catabolism 10 4.13e-01 0.149000 5.57e-01
Translation initiation complex formation 57 5.11e-02 -0.149000 1.25e-01
RAF/MAP kinase cascade 220 1.37e-04 -0.149000 1.66e-03
SHC1 events in ERBB2 signaling 18 2.74e-01 -0.149000 4.20e-01
MAPK family signaling cascades 264 3.17e-05 -0.149000 5.03e-04
Fc epsilon receptor (FCERI) signaling 112 6.54e-03 -0.149000 2.65e-02
Calnexin/calreticulin cycle 26 1.89e-01 -0.149000 3.25e-01
Cell Cycle Checkpoints 246 5.92e-05 0.149000 8.19e-04
Developmental Biology 1033 7.71e-16 -0.149000 1.31e-13
Signaling by CSF3 (G-CSF) 28 1.74e-01 -0.149000 3.07e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 60 4.67e-02 -0.149000 1.18e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 1.35e-01 -0.148000 2.60e-01
TNF signaling 56 5.64e-02 -0.147000 1.34e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 31 1.56e-01 -0.147000 2.88e-01
RMTs methylate histone arginines 38 1.16e-01 0.147000 2.30e-01
Nicotinamide salvaging 15 3.24e-01 -0.147000 4.71e-01
Regulation of expression of SLITs and ROBOs 154 1.75e-03 -0.146000 1.10e-02
Amino acids regulate mTORC1 51 7.11e-02 0.146000 1.60e-01
Gap junction trafficking 31 1.60e-01 -0.146000 2.93e-01
Organelle biogenesis and maintenance 280 2.84e-05 0.145000 4.71e-04
Signal transduction by L1 21 2.50e-01 -0.145000 4.00e-01
Cohesin Loading onto Chromatin 10 4.27e-01 0.145000 5.71e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 3.16e-01 0.145000 4.63e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 92 1.66e-02 0.145000 5.49e-02
Amplification of signal from the kinetochores 92 1.66e-02 0.145000 5.49e-02
Senescence-Associated Secretory Phenotype (SASP) 65 4.39e-02 -0.145000 1.13e-01
Defects in vitamin and cofactor metabolism 21 2.52e-01 -0.144000 4.01e-01
Mitotic Spindle Checkpoint 109 9.33e-03 0.144000 3.50e-02
NR1H2 and NR1H3-mediated signaling 39 1.20e-01 -0.144000 2.35e-01
Assembly and cell surface presentation of NMDA receptors 33 1.52e-01 -0.144000 2.84e-01
Integrin signaling 23 2.33e-01 -0.144000 3.79e-01
VEGFA-VEGFR2 Pathway 90 1.87e-02 -0.143000 5.98e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 64 4.76e-02 -0.143000 1.20e-01
Initiation of Nuclear Envelope (NE) Reformation 19 2.80e-01 0.143000 4.27e-01
Sema3A PAK dependent Axon repulsion 16 3.22e-01 -0.143000 4.69e-01
Transport of small molecules 523 2.40e-08 -0.143000 1.22e-06
ADP signalling through P2Y purinoceptor 1 21 2.58e-01 -0.143000 4.09e-01
Interferon gamma signaling 74 3.48e-02 -0.142000 9.70e-02
NPAS4 regulates expression of target genes 17 3.11e-01 -0.142000 4.58e-01
Signaling by high-kinase activity BRAF mutants 32 1.65e-01 -0.142000 2.98e-01
RNA Polymerase I Promoter Clearance 66 4.70e-02 0.141000 1.19e-01
RNA Polymerase I Transcription 66 4.70e-02 0.141000 1.19e-01
HATs acetylate histones 94 1.81e-02 0.141000 5.84e-02
Polymerase switching on the C-strand of the telomere 26 2.13e-01 0.141000 3.53e-01
APC/C:Cdc20 mediated degradation of Securin 55 7.09e-02 0.141000 1.60e-01
PECAM1 interactions 10 4.41e-01 -0.141000 5.84e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 34 1.56e-01 -0.140000 2.89e-01
Signaling by NOTCH4 71 4.08e-02 -0.140000 1.08e-01
Formation of Incision Complex in GG-NER 43 1.12e-01 0.140000 2.25e-01
Regulation of Apoptosis 40 1.27e-01 0.139000 2.47e-01
Pexophagy 10 4.46e-01 -0.139000 5.88e-01
mTORC1-mediated signalling 24 2.42e-01 0.138000 3.90e-01
Signaling by EGFR 49 9.50e-02 -0.138000 1.99e-01
Regulation of Expression and Function of Type II Classical Cadherins 27 2.15e-01 -0.138000 3.55e-01
Regulation of Homotypic Cell-Cell Adhesion 27 2.15e-01 -0.138000 3.55e-01
PIWI-interacting RNA (piRNA) biogenesis 21 2.75e-01 0.138000 4.21e-01
MET activates PTK2 signaling 27 2.16e-01 -0.138000 3.56e-01
Sulfur amino acid metabolism 22 2.65e-01 0.137000 4.11e-01
Fatty acyl-CoA biosynthesis 32 1.80e-01 -0.137000 3.15e-01
Telomere Maintenance 80 3.43e-02 0.137000 9.63e-02
Glycogen storage diseases 14 3.76e-01 -0.137000 5.22e-01
Depolymerization of the Nuclear Lamina 15 3.60e-01 0.136000 5.07e-01
Cellular response to starvation 149 4.16e-03 -0.136000 1.95e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 2.22e-01 -0.136000 3.63e-01
CDC42 GTPase cycle 150 4.14e-03 -0.136000 1.95e-02
Cross-presentation of soluble exogenous antigens (endosomes) 34 1.73e-01 0.135000 3.06e-01
Inflammasomes 17 3.37e-01 -0.134000 4.83e-01
S Phase 150 4.62e-03 0.134000 2.08e-02
Immune System 1508 5.24e-18 -0.134000 1.33e-15
Cardiogenesis 23 2.68e-01 -0.133000 4.15e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.07e-01 -0.133000 3.46e-01
MAP2K and MAPK activation 36 1.67e-01 -0.133000 3.00e-01
G beta:gamma signalling through PI3Kgamma 20 3.04e-01 -0.133000 4.50e-01
Methylation 14 3.89e-01 0.133000 5.36e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 8.11e-02 -0.132000 1.77e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 4.28e-01 -0.132000 5.71e-01
alpha-linolenic acid (ALA) metabolism 12 4.28e-01 -0.132000 5.71e-01
Oncogenic MAPK signaling 76 4.64e-02 -0.132000 1.18e-01
ADP signalling through P2Y purinoceptor 12 16 3.61e-01 -0.132000 5.07e-01
Sensory Perception 154 4.79e-03 -0.132000 2.14e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 76 4.79e-02 0.131000 1.20e-01
DAG and IP3 signaling 37 1.69e-01 -0.131000 3.01e-01
RHO GTPases Activate WASPs and WAVEs 35 1.81e-01 -0.131000 3.15e-01
Aquaporin-mediated transport 35 1.85e-01 -0.129000 3.19e-01
Orc1 removal from chromatin 58 8.83e-02 0.129000 1.88e-01
SUMOylation of chromatin organization proteins 57 9.16e-02 0.129000 1.93e-01
Inactivation of CSF3 (G-CSF) signaling 23 2.84e-01 -0.129000 4.32e-01
Response of Mtb to phagocytosis 22 2.95e-01 -0.129000 4.43e-01
Signaling by ROBO receptors 199 1.76e-03 -0.129000 1.10e-02
Signaling by RAF1 mutants 36 1.82e-01 -0.129000 3.15e-01
Glucagon signaling in metabolic regulation 27 2.48e-01 -0.129000 3.97e-01
Replacement of protamines by nucleosomes in the male pronucleus 12 4.41e-01 -0.128000 5.84e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 8.31e-02 0.128000 1.80e-01
MTOR signalling 40 1.61e-01 0.128000 2.94e-01
Programmed Cell Death 179 3.15e-03 -0.128000 1.64e-02
Assembly of the pre-replicative complex 89 3.69e-02 0.128000 1.01e-01
Switching of origins to a post-replicative state 79 4.98e-02 0.128000 1.23e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 4.26e-01 -0.127000 5.71e-01
TBC/RABGAPs 43 1.49e-01 -0.127000 2.80e-01
Signaling by Insulin receptor 67 7.27e-02 -0.127000 1.62e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 87 4.10e-02 -0.127000 1.08e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 87 4.10e-02 -0.127000 1.08e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 87 4.10e-02 -0.127000 1.08e-01
Telomere Extension By Telomerase 23 2.93e-01 0.127000 4.40e-01
Signaling by EGFR in Cancer 22 3.04e-01 -0.127000 4.50e-01
Sphingolipid de novo biosynthesis 33 2.08e-01 -0.127000 3.48e-01
RAB geranylgeranylation 60 9.09e-02 -0.126000 1.92e-01
Cytochrome c-mediated apoptotic response 13 4.31e-01 -0.126000 5.73e-01
VEGFR2 mediated vascular permeability 24 2.85e-01 -0.126000 4.32e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 1.59e-01 0.126000 2.91e-01
TNFR2 non-canonical NF-kB pathway 73 6.50e-02 -0.125000 1.49e-01
SUMOylation of RNA binding proteins 47 1.39e-01 0.125000 2.64e-01
SUMOylation of intracellular receptors 27 2.62e-01 -0.125000 4.10e-01
RHOF GTPase cycle 41 1.67e-01 -0.125000 3.00e-01
Synthesis of PIPs at the plasma membrane 49 1.31e-01 -0.125000 2.53e-01
Signaling by ALK fusions and activated point mutants 87 4.49e-02 -0.124000 1.15e-01
Signaling by ALK in cancer 87 4.49e-02 -0.124000 1.15e-01
Drug ADME 54 1.15e-01 -0.124000 2.29e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 3.63e-01 -0.124000 5.08e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.81e-01 0.124000 3.15e-01
p53-Independent DNA Damage Response 39 1.81e-01 0.124000 3.15e-01
p53-Independent G1/S DNA damage checkpoint 39 1.81e-01 0.124000 3.15e-01
SUMOylation of DNA damage response and repair proteins 76 6.24e-02 0.124000 1.45e-01
STING mediated induction of host immune responses 15 4.09e-01 -0.123000 5.54e-01
Assembly of the ORC complex at the origin of replication 25 2.87e-01 0.123000 4.35e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 1.18e-01 0.123000 2.33e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.81e-02 0.123000 1.20e-01
ISG15 antiviral mechanism 73 7.13e-02 0.122000 1.60e-01
Regulation of TP53 Activity 153 9.33e-03 0.122000 3.50e-02
Ubiquitin-dependent degradation of Cyclin D 39 1.93e-01 0.121000 3.29e-01
The phototransduction cascade 20 3.51e-01 0.120000 4.98e-01
Vpu mediated degradation of CD4 38 2.00e-01 0.120000 3.37e-01
G1/S Transition 121 2.25e-02 0.120000 6.96e-02
DNA Damage Bypass 47 1.54e-01 0.120000 2.87e-01
Degradation of DVL 44 1.69e-01 0.120000 3.01e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 24 3.11e-01 -0.120000 4.58e-01
Termination of translesion DNA synthesis 32 2.42e-01 0.119000 3.90e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.12e-01 -0.118000 5.57e-01
Prolactin receptor signaling 11 4.98e-01 0.118000 6.33e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 5.18e-01 -0.118000 6.51e-01
Cell Cycle 612 6.52e-07 0.118000 2.21e-05
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 16 4.14e-01 0.118000 5.58e-01
Regulation of CDH11 Expression and Function 26 2.99e-01 -0.118000 4.47e-01
Centrosome maturation 81 6.77e-02 0.117000 1.54e-01
Recruitment of mitotic centrosome proteins and complexes 81 6.77e-02 0.117000 1.54e-01
Eicosanoid ligand-binding receptors 10 5.20e-01 0.117000 6.52e-01
Pregnenolone biosynthesis 10 5.22e-01 -0.117000 6.53e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 2.12e-01 0.117000 3.51e-01
Translation 291 6.05e-04 0.117000 4.97e-03
Myogenesis 23 3.32e-01 -0.117000 4.78e-01
Basigin interactions 20 3.67e-01 -0.117000 5.14e-01
Metabolism of carbohydrates 242 1.81e-03 -0.116000 1.12e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 4.06e-01 -0.116000 5.50e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 4.06e-01 -0.116000 5.50e-01
CaM pathway 31 2.62e-01 -0.116000 4.10e-01
Calmodulin induced events 31 2.62e-01 -0.116000 4.10e-01
Regulation of TP53 Activity through Methylation 19 3.80e-01 -0.116000 5.26e-01
C-type lectin receptors (CLRs) 102 4.32e-02 -0.116000 1.12e-01
Co-inhibition by CTLA4 17 4.10e-01 -0.116000 5.54e-01
Synthesis of substrates in N-glycan biosythesis 59 1.26e-01 -0.115000 2.44e-01
PKMTs methylate histone lysines 43 1.91e-01 0.115000 3.27e-01
Signaling by BMP 25 3.19e-01 -0.115000 4.66e-01
Regulation of innate immune responses to cytosolic DNA 13 4.72e-01 -0.115000 6.11e-01
Mitotic Telophase/Cytokinesis 13 4.74e-01 0.115000 6.11e-01
HCMV Early Events 88 6.28e-02 0.115000 1.45e-01
Proteasome assembly 50 1.61e-01 0.115000 2.94e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 65 1.11e-01 -0.114000 2.22e-01
RHO GTPases Activate ROCKs 19 3.88e-01 -0.114000 5.35e-01
Gastrulation 98 5.06e-02 -0.114000 1.25e-01
Signaling by FGFR3 34 2.49e-01 -0.114000 3.99e-01
Signaling by ERBB2 46 1.82e-01 -0.114000 3.15e-01
Binding and Uptake of Ligands by Scavenger Receptors 20 3.79e-01 -0.114000 5.26e-01
Synthesis of PC 25 3.26e-01 -0.114000 4.72e-01
Bile acid and bile salt metabolism 29 2.91e-01 0.113000 4.39e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 48 1.74e-01 -0.113000 3.07e-01
Regulation of actin dynamics for phagocytic cup formation 55 1.46e-01 -0.113000 2.76e-01
Phosphorylation of the APC/C 20 3.81e-01 0.113000 5.27e-01
Retrograde transport at the Trans-Golgi-Network 49 1.71e-01 0.113000 3.03e-01
Cytoprotection by HMOX1 50 1.67e-01 0.113000 3.00e-01
Defective CFTR causes cystic fibrosis 47 1.81e-01 0.113000 3.15e-01
Synthesis, secretion, and deacylation of Ghrelin 10 5.38e-01 -0.112000 6.68e-01
Mitotic G1 phase and G1/S transition 137 2.32e-02 0.112000 7.10e-02
Membrane binding and targetting of GAG proteins 14 4.67e-01 -0.112000 6.05e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 4.67e-01 -0.112000 6.05e-01
Signaling by TGFB family members 143 2.06e-02 -0.112000 6.47e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 4.52e-01 0.112000 5.93e-01
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 11 5.20e-01 0.112000 6.52e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 5.41e-01 0.112000 6.70e-01
Mitotic Anaphase 213 5.01e-03 0.112000 2.19e-02
Apoptosis 152 1.77e-02 -0.112000 5.77e-02
Glycerophospholipid biosynthesis 101 5.39e-02 -0.111000 1.30e-01
RHOJ GTPase cycle 54 1.58e-01 -0.111000 2.91e-01
RHO GTPases activate PKNs 47 1.89e-01 -0.111000 3.24e-01
Mitotic Metaphase and Anaphase 214 5.28e-03 0.111000 2.27e-02
Interleukin-27 signaling 10 5.45e-01 -0.111000 6.74e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 12 5.08e-01 -0.110000 6.39e-01
Uptake and actions of bacterial toxins 26 3.31e-01 0.110000 4.76e-01
TAK1-dependent IKK and NF-kappa-B activation 40 2.29e-01 -0.110000 3.73e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 4.21e-01 -0.110000 5.65e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 4.21e-01 -0.110000 5.65e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 14 4.78e-01 0.109000 6.16e-01
Signaling by WNT 250 2.94e-03 -0.109000 1.57e-02
RNA Polymerase I Promoter Escape 47 1.97e-01 0.109000 3.34e-01
Glycosphingolipid catabolism 33 2.81e-01 -0.109000 4.27e-01
Separation of Sister Chromatids 169 1.53e-02 0.108000 5.14e-02
Formation of the beta-catenin:TCF transactivating complex 47 1.99e-01 -0.108000 3.37e-01
Intracellular signaling by second messengers 273 2.16e-03 -0.108000 1.25e-02
Defective B3GALTL causes PpS 32 2.91e-01 -0.108000 4.39e-01
Advanced glycosylation endproduct receptor signaling 10 5.55e-01 -0.108000 6.84e-01
RAC1 GTPase cycle 173 1.48e-02 -0.107000 5.01e-02
NIK–>noncanonical NF-kB signaling 46 2.08e-01 0.107000 3.48e-01
Phospholipid metabolism 175 1.46e-02 -0.107000 4.98e-02
Adherens junctions interactions 45 2.15e-01 -0.107000 3.55e-01
Heme signaling 41 2.37e-01 -0.107000 3.83e-01
Downregulation of ERBB2:ERBB3 signaling 13 5.05e-01 -0.107000 6.37e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 14 4.90e-01 -0.106000 6.26e-01
PIP3 activates AKT signaling 237 4.84e-03 -0.106000 2.15e-02
RHOD GTPase cycle 52 1.85e-01 -0.106000 3.19e-01
Ca-dependent events 33 2.91e-01 -0.106000 4.39e-01
SARS-CoV-2 Infection 264 3.09e-03 -0.106000 1.62e-02
Plasma lipoprotein clearance 30 3.16e-01 -0.106000 4.63e-01
Diseases of metabolism 208 8.65e-03 -0.106000 3.28e-02
RAF activation 32 3.01e-01 -0.106000 4.49e-01
Cilium Assembly 186 1.32e-02 0.105000 4.63e-02
PI-3K cascade:FGFR3 12 5.29e-01 -0.105000 6.60e-01
PI Metabolism 75 1.16e-01 -0.105000 2.30e-01
L1CAM interactions 99 7.23e-02 -0.105000 1.61e-01
Antigen processing-Cross presentation 80 1.07e-01 -0.104000 2.16e-01
Signaling by NOTCH 177 1.70e-02 -0.104000 5.61e-02
SCF-beta-TrCP mediated degradation of Emi1 42 2.44e-01 0.104000 3.92e-01
Regulation of NPAS4 gene expression 12 5.35e-01 0.104000 6.66e-01
Cell Cycle, Mitotic 493 8.49e-05 0.103000 1.10e-03
Apoptosis induced DNA fragmentation 10 5.71e-01 0.103000 6.95e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 2.79e-01 0.103000 4.25e-01
Transcription of E2F targets under negative control by DREAM complex 19 4.39e-01 0.103000 5.83e-01
Hyaluronan uptake and degradation 10 5.75e-01 -0.103000 6.98e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 4.16e-01 -0.102000 5.60e-01
G-protein beta:gamma signalling 25 3.76e-01 -0.102000 5.22e-01
Regulation of RUNX2 expression and activity 58 1.79e-01 0.102000 3.14e-01
Mitotic Prometaphase 195 1.41e-02 0.102000 4.82e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 5.42e-01 -0.102000 6.70e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.98e-01 -0.102000 4.47e-01
Chromatin modifying enzymes 213 1.08e-02 0.101000 3.94e-02
Chromatin organization 213 1.08e-02 0.101000 3.94e-02
HSF1-dependent transactivation 30 3.38e-01 0.101000 4.84e-01
Diseases of signal transduction by growth factor receptors and second messengers 408 4.78e-04 -0.101000 4.30e-03
Nuclear events stimulated by ALK signaling in cancer 30 3.39e-01 -0.101000 4.85e-01
CDK-mediated phosphorylation and removal of Cdc6 60 1.77e-01 0.101000 3.11e-01
activated TAK1 mediates p38 MAPK activation 22 4.15e-01 -0.100000 5.59e-01
Hh mutants are degraded by ERAD 43 2.55e-01 0.100000 4.05e-01
eNOS activation 12 5.49e-01 0.099900 6.78e-01
O-glycosylation of TSR domain-containing proteins 33 3.21e-01 -0.099900 4.68e-01
Zinc transporters 11 5.66e-01 -0.099800 6.92e-01
Circadian Clock 64 1.69e-01 -0.099400 3.01e-01
Fcgamma receptor (FCGR) dependent phagocytosis 77 1.32e-01 -0.099300 2.55e-01
Metabolic disorders of biological oxidation enzymes 24 4.00e-01 0.099200 5.45e-01
Signaling by the B Cell Receptor (BCR) 87 1.11e-01 -0.098800 2.23e-01
M Phase 351 1.50e-03 0.098700 9.69e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 5.90e-01 0.098500 7.07e-01
Vif-mediated degradation of APOBEC3G 41 2.76e-01 0.098400 4.21e-01
Metabolism of nucleotides 86 1.16e-01 0.098100 2.30e-01
MAPK3 (ERK1) activation 10 5.93e-01 -0.097700 7.10e-01
Prostacyclin signalling through prostacyclin receptor 15 5.13e-01 -0.097500 6.45e-01
Activation of SMO 16 5.00e-01 -0.097500 6.34e-01
Rab regulation of trafficking 118 6.85e-02 -0.097100 1.56e-01
STAT5 activation downstream of FLT3 ITD mutants 10 5.96e-01 -0.096800 7.14e-01
Transcriptional regulation by RUNX3 82 1.30e-01 -0.096700 2.52e-01
DNA Double Strand Break Response 50 2.37e-01 0.096700 3.83e-01
Mitotic Prophase 98 9.83e-02 0.096700 2.02e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 11 5.79e-01 0.096500 7.02e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 39 3.01e-01 -0.095700 4.49e-01
Signaling by RAS mutants 39 3.01e-01 -0.095700 4.49e-01
Signaling by moderate kinase activity BRAF mutants 39 3.01e-01 -0.095700 4.49e-01
Signaling downstream of RAS mutants 39 3.01e-01 -0.095700 4.49e-01
Glutathione synthesis and recycling 11 5.83e-01 0.095600 7.04e-01
Scavenging by Class A Receptors 11 5.85e-01 -0.095200 7.04e-01
Signaling by SCF-KIT 38 3.12e-01 -0.094800 4.59e-01
Spry regulation of FGF signaling 16 5.12e-01 0.094700 6.44e-01
Intraflagellar transport 47 2.62e-01 0.094600 4.10e-01
Stabilization of p53 42 2.90e-01 0.094400 4.38e-01
PI-3K cascade:FGFR4 12 5.73e-01 -0.094100 6.96e-01
Nuclear events mediated by NFE2L2 81 1.44e-01 0.093900 2.73e-01
Inactivation, recovery and regulation of the phototransduction cascade 19 4.80e-01 0.093600 6.18e-01
EGFR downregulation 28 3.92e-01 -0.093500 5.38e-01
TCF dependent signaling in response to WNT 166 3.80e-02 -0.093400 1.02e-01
Acetylcholine Neurotransmitter Release Cycle 13 5.60e-01 0.093300 6.89e-01
Oncogene Induced Senescence 31 3.69e-01 -0.093200 5.15e-01
Signaling by Non-Receptor Tyrosine Kinases 49 2.59e-01 -0.093200 4.09e-01
Signaling by PTK6 49 2.59e-01 -0.093200 4.09e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 49 2.61e-01 0.092900 4.10e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 4.73e-01 -0.092700 6.11e-01
Neurodegenerative Diseases 20 4.73e-01 -0.092700 6.11e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 4.64e-01 0.092300 6.03e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 4.64e-01 0.092300 6.03e-01
Smooth Muscle Contraction 36 3.39e-01 -0.092200 4.84e-01
Asymmetric localization of PCP proteins 51 2.56e-01 0.091900 4.06e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 3.03e-01 0.091900 4.49e-01
Cleavage of the damaged pyrimidine 29 3.94e-01 0.091500 5.38e-01
Depyrimidination 29 3.94e-01 0.091500 5.38e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 3.94e-01 0.091500 5.38e-01
Meiosis 66 1.99e-01 0.091500 3.36e-01
Modulation of host responses by IFN-stimulated genes 18 5.03e-01 -0.091300 6.35e-01
RHO GTPase cycle 423 1.31e-03 -0.091200 8.69e-03
Signaling by PDGFRA extracellular domain mutants 12 5.86e-01 -0.090900 7.04e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 5.86e-01 -0.090900 7.04e-01
Base-Excision Repair, AP Site Formation 31 3.82e-01 0.090800 5.28e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 51 2.64e-01 0.090500 4.11e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 52 2.59e-01 0.090500 4.09e-01
RAB GEFs exchange GTP for GDP on RABs 86 1.47e-01 -0.090400 2.77e-01
Regulation of MECP2 expression and activity 29 4.00e-01 0.090300 5.45e-01
DNA methylation 20 4.85e-01 -0.090200 6.21e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 4.85e-01 0.090100 6.21e-01
Dectin-1 mediated noncanonical NF-kB signaling 47 2.86e-01 0.090000 4.33e-01
Metabolism of cofactors 23 4.55e-01 0.090000 5.94e-01
RHOA GTPase cycle 143 6.62e-02 -0.089000 1.51e-01
Josephin domain DUBs 10 6.27e-01 -0.088800 7.41e-01
Nuclear Envelope (NE) Reassembly 69 2.03e-01 0.088600 3.41e-01
Aggrephagy 34 3.71e-01 -0.088600 5.17e-01
Influenza Viral RNA Transcription and Replication 133 7.83e-02 -0.088400 1.73e-01
Transcriptional Regulation by TP53 341 5.20e-03 0.088100 2.27e-02
Maturation of spike protein 9694548 36 3.62e-01 -0.087800 5.07e-01
Phase 0 - rapid depolarisation 25 4.49e-01 -0.087600 5.89e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 5.86e-01 -0.087300 7.04e-01
DCC mediated attractive signaling 14 5.73e-01 -0.087100 6.96e-01
RHOB GTPase cycle 69 2.11e-01 -0.087100 3.50e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 3.94e-01 -0.087100 5.38e-01
Phase 2 - plateau phase 11 6.17e-01 -0.087100 7.32e-01
Apoptotic execution phase 44 3.20e-01 -0.086700 4.67e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 5.38e-01 -0.086300 6.68e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 2.48e-01 0.086200 3.97e-01
rRNA processing 215 2.96e-02 0.086100 8.58e-02
Signaling by FGFR4 33 3.92e-01 -0.086100 5.38e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 39 3.54e-01 0.085800 5.01e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 4.24e-01 -0.085700 5.68e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 5.07e-01 0.085700 6.39e-01
Pre-NOTCH Expression and Processing 68 2.23e-01 -0.085400 3.65e-01
HSF1 activation 25 4.60e-01 0.085400 6.00e-01
HDMs demethylate histones 21 5.01e-01 -0.084800 6.34e-01
Peptide hormone metabolism 52 2.92e-01 -0.084500 4.39e-01
Signaling by Retinoic Acid 33 4.02e-01 -0.084300 5.47e-01
EML4 and NUDC in mitotic spindle formation 108 1.30e-01 0.084300 2.52e-01
Hh mutants abrogate ligand secretion 44 3.33e-01 0.084300 4.80e-01
Epigenetic regulation of gene expression 256 2.05e-02 0.084100 6.47e-02
Other interleukin signaling 18 5.38e-01 -0.083800 6.68e-01
Neddylation 213 3.54e-02 0.083700 9.80e-02
COPI-dependent Golgi-to-ER retrograde traffic 89 1.72e-01 0.083700 3.05e-01
Resolution of Sister Chromatid Cohesion 118 1.19e-01 0.083200 2.34e-01
Sensory perception of taste 18 5.42e-01 0.083100 6.70e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 4.47e-01 0.082900 5.89e-01
Cytosolic sensors of pathogen-associated DNA 61 2.63e-01 -0.082800 4.11e-01
RHOQ GTPase cycle 58 2.76e-01 -0.082700 4.21e-01
Anchoring fibril formation 12 6.20e-01 -0.082700 7.34e-01
ER to Golgi Anterograde Transport 141 9.18e-02 0.082300 1.93e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 42 3.57e-01 0.082100 5.03e-01
SARS-CoV Infections 363 7.31e-03 -0.082000 2.89e-02
Pre-NOTCH Transcription and Translation 53 3.02e-01 -0.082000 4.49e-01
TP53 Regulates Metabolic Genes 76 2.17e-01 0.081900 3.56e-01
Interleukin-1 family signaling 119 1.24e-01 -0.081600 2.42e-01
Metabolism of lipids 612 5.83e-04 -0.081600 4.91e-03
Beta-oxidation of very long chain fatty acids 11 6.40e-01 0.081500 7.51e-01
Cargo concentration in the ER 29 4.48e-01 0.081500 5.89e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 2.65e-01 0.081300 4.11e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 2.61e-01 0.081300 4.10e-01
Paracetamol ADME 17 5.63e-01 -0.081100 6.89e-01
Signaling by TGF-beta Receptor Complex 90 1.84e-01 -0.081000 3.19e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 3.90e-01 0.080600 5.36e-01
Regulation of RUNX3 expression and activity 44 3.55e-01 0.080600 5.01e-01
Inositol phosphate metabolism 42 3.68e-01 -0.080400 5.14e-01
Maturation of hRSV A proteins 13 6.17e-01 0.080200 7.32e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 4.90e-01 0.079700 6.26e-01
RHOV GTPase cycle 37 4.04e-01 -0.079400 5.49e-01
FGFR2 mutant receptor activation 24 5.01e-01 0.079300 6.34e-01
Azathioprine ADME 18 5.61e-01 -0.079100 6.89e-01
Metabolism of nitric oxide: NOS3 activation and regulation 16 5.86e-01 0.078700 7.04e-01
Polo-like kinase mediated events 16 5.87e-01 0.078500 7.04e-01
Diseases of carbohydrate metabolism 29 4.66e-01 -0.078200 6.05e-01
Gene expression (Transcription) 1352 1.68e-06 0.077900 5.02e-05
Downregulation of TGF-beta receptor signaling 26 4.94e-01 0.077500 6.30e-01
Adaptive Immune System 598 1.26e-03 -0.077300 8.39e-03
G beta:gamma signalling through PLC beta 15 6.05e-01 -0.077200 7.22e-01
COPI-independent Golgi-to-ER retrograde traffic 45 3.71e-01 -0.077000 5.17e-01
Beta-catenin phosphorylation cascade 17 5.82e-01 -0.077000 7.04e-01
TRP channels 19 5.62e-01 -0.076900 6.89e-01
Olfactory Signaling Pathway 26 4.98e-01 -0.076800 6.33e-01
Ub-specific processing proteases 159 9.65e-02 0.076400 2.00e-01
Detoxification of Reactive Oxygen Species 28 4.85e-01 0.076300 6.21e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 5.77e-01 -0.076000 7.00e-01
Signaling by FGFR1 in disease 32 4.58e-01 -0.075900 5.97e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 3.07e-01 0.075600 4.54e-01
ROS and RNS production in phagocytes 27 4.97e-01 -0.075500 6.32e-01
Trafficking of GluR2-containing AMPA receptors 14 6.26e-01 0.075300 7.40e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.20e-01 0.074400 6.52e-01
Negative regulation of FLT3 13 6.45e-01 -0.073900 7.55e-01
Glycogen breakdown (glycogenolysis) 13 6.47e-01 -0.073300 7.57e-01
Defective pyroptosis 29 4.95e-01 0.073200 6.30e-01
Interleukin-37 signaling 17 6.02e-01 -0.073100 7.19e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 6.89e-01 -0.073100 7.94e-01
Transcriptional activation of mitochondrial biogenesis 54 3.55e-01 0.072800 5.01e-01
Cellular response to chemical stress 173 1.02e-01 0.072100 2.08e-01
Mitochondrial unfolded protein response (UPRmt) 16 6.18e-01 0.072000 7.33e-01
G2/M Transition 178 9.93e-02 0.071700 2.04e-01
Mitotic G2-G2/M phases 180 9.75e-02 0.071600 2.02e-01
RNA Polymerase II Transcription 1150 4.55e-05 0.071500 6.61e-04
Downstream signaling events of B Cell Receptor (BCR) 66 3.15e-01 -0.071500 4.62e-01
Activation of kainate receptors upon glutamate binding 23 5.54e-01 -0.071300 6.83e-01
Signaling by Hippo 20 5.85e-01 -0.070600 7.04e-01
Constitutive Signaling by Overexpressed ERBB2 11 6.85e-01 -0.070500 7.92e-01
Degradation of AXIN 42 4.30e-01 0.070400 5.73e-01
Mitophagy 38 4.53e-01 0.070400 5.93e-01
Insulin receptor recycling 26 5.36e-01 0.070200 6.67e-01
Amino acid transport across the plasma membrane 23 5.61e-01 0.070100 6.89e-01
Negative regulators of DDX58/IFIH1 signaling 35 4.75e-01 -0.069900 6.12e-01
VxPx cargo-targeting to cilium 18 6.09e-01 -0.069700 7.26e-01
Positive epigenetic regulation of rRNA expression 62 3.44e-01 0.069600 4.90e-01
EPHB-mediated forward signaling 41 4.43e-01 -0.069200 5.85e-01
Somitogenesis 44 4.33e-01 0.068400 5.75e-01
Role of phospholipids in phagocytosis 20 5.97e-01 -0.068200 7.15e-01
Negative epigenetic regulation of rRNA expression 65 3.45e-01 0.067800 4.91e-01
Lysosome Vesicle Biogenesis 33 5.02e-01 0.067500 6.35e-01
Cellular Senescence 144 1.62e-01 -0.067500 2.95e-01
Regulation of APC/C activators between G1/S and early anaphase 68 3.36e-01 0.067400 4.83e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 4.05e-01 -0.067400 5.50e-01
Metabolism of steroids 124 1.96e-01 -0.067300 3.33e-01
KEAP1-NFE2L2 pathway 106 2.34e-01 0.066900 3.80e-01
Translesion synthesis by POLI 17 6.33e-01 0.066800 7.46e-01
Disease 1526 1.50e-05 -0.066600 2.95e-04
G0 and Early G1 27 5.51e-01 0.066300 6.80e-01
Golgi-to-ER retrograde transport 122 2.07e-01 0.066200 3.46e-01
HCMV Late Events 72 3.34e-01 0.065800 4.81e-01
Signaling by ALK 25 5.69e-01 -0.065800 6.94e-01
Formation of tubulin folding intermediates by CCT/TriC 21 6.04e-01 -0.065500 7.21e-01
Signaling by FGFR4 in disease 11 7.07e-01 -0.065300 8.01e-01
ER-Phagosome pathway 70 3.45e-01 -0.065300 4.91e-01
UCH proteinases 77 3.30e-01 0.064200 4.76e-01
Transcriptional regulation of white adipocyte differentiation 78 3.27e-01 -0.064200 4.74e-01
RND2 GTPase cycle 40 4.84e-01 -0.063900 6.21e-01
Signaling by cytosolic FGFR1 fusion mutants 18 6.40e-01 -0.063700 7.51e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 33 5.27e-01 -0.063700 6.58e-01
Recycling pathway of L1 40 4.88e-01 -0.063300 6.25e-01
NoRC negatively regulates rRNA expression 62 3.90e-01 0.063200 5.36e-01
Regulation of IFNG signaling 12 7.06e-01 0.062800 8.01e-01
Recruitment of NuMA to mitotic centrosomes 88 3.10e-01 0.062600 4.58e-01
MASTL Facilitates Mitotic Progression 10 7.32e-01 -0.062500 8.18e-01
Signaling by Rho GTPases 617 8.14e-03 -0.062500 3.13e-02
Synaptic adhesion-like molecules 18 6.48e-01 0.062200 7.57e-01
Signaling by FGFR 77 3.46e-01 -0.062200 4.91e-01
CLEC7A (Dectin-1) signaling 83 3.29e-01 -0.062000 4.75e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 73 3.62e-01 -0.061800 5.07e-01
PCP/CE pathway 78 3.50e-01 0.061200 4.96e-01
Telomere C-strand synthesis initiation 13 7.02e-01 0.061200 8.01e-01
Norepinephrine Neurotransmitter Release Cycle 14 6.93e-01 0.061000 7.97e-01
Synthesis of PA 27 5.87e-01 0.060400 7.04e-01
HCMV Infection 112 2.70e-01 0.060400 4.17e-01
Negative regulation of NOTCH4 signaling 44 4.89e-01 0.060300 6.25e-01
Antiviral mechanism by IFN-stimulated genes 141 2.17e-01 0.060300 3.56e-01
Signaling by ERBB2 TMD/JMD mutants 18 6.58e-01 0.060200 7.67e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 6.15e-01 0.059200 7.32e-01
RAC2 GTPase cycle 84 3.50e-01 -0.059100 4.96e-01
HDACs deacetylate histones 48 4.82e-01 0.058700 6.19e-01
Regulation of RUNX1 Expression and Activity 18 6.66e-01 0.058700 7.75e-01
Constitutive Signaling by EGFRvIII 14 7.04e-01 -0.058700 8.01e-01
Signaling by EGFRvIII in Cancer 14 7.04e-01 -0.058700 8.01e-01
Regulation of PTEN gene transcription 61 4.31e-01 -0.058400 5.73e-01
G beta:gamma signalling through BTK 13 7.17e-01 -0.058100 8.08e-01
Signaling by Nuclear Receptors 223 1.36e-01 -0.058000 2.61e-01
TCR signaling 89 3.45e-01 -0.058000 4.91e-01
Cyclin E associated events during G1/S transition 73 3.93e-01 0.057800 5.38e-01
Negative regulation of FGFR2 signaling 25 6.18e-01 -0.057600 7.33e-01
Meiotic synapsis 40 5.29e-01 -0.057500 6.60e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 633 1.39e-02 -0.057400 4.75e-02
Downregulation of ERBB2 signaling 25 6.23e-01 -0.056700 7.37e-01
Generic Transcription Pathway 1031 2.19e-03 0.056600 1.25e-02
B-WICH complex positively regulates rRNA expression 47 5.03e-01 0.056500 6.35e-01
Cytochrome P450 - arranged by substrate type 35 5.63e-01 -0.056400 6.90e-01
Golgi Associated Vesicle Biogenesis 55 4.70e-01 0.056300 6.09e-01
Diseases associated with N-glycosylation of proteins 20 6.64e-01 0.056200 7.72e-01
Signaling by BRAF and RAF1 fusions 60 4.52e-01 -0.056100 5.93e-01
Estrogen-dependent gene expression 103 3.28e-01 0.055800 4.74e-01
Oxidative Stress Induced Senescence 77 4.01e-01 -0.055400 5.46e-01
LGI-ADAM interactions 10 7.64e-01 0.054900 8.44e-01
Interferon Signaling 231 1.52e-01 -0.054800 2.83e-01
COPI-mediated anterograde transport 91 3.75e-01 0.053800 5.21e-01
Nicotinate metabolism 25 6.42e-01 -0.053700 7.53e-01
Cyclin A:Cdk2-associated events at S phase entry 75 4.22e-01 0.053600 5.66e-01
Uptake and function of anthrax toxins 11 7.59e-01 -0.053400 8.41e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.40e-01 -0.053200 8.25e-01
Cytosolic sulfonation of small molecules 17 7.05e-01 -0.053000 8.01e-01
Glutamate Neurotransmitter Release Cycle 21 6.75e-01 -0.052900 7.83e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 7.33e-01 -0.052800 8.18e-01
RHO GTPase Effectors 256 1.50e-01 -0.052300 2.81e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 49 5.28e-01 0.052100 6.59e-01
Suppression of phagosomal maturation 13 7.45e-01 0.052100 8.30e-01
Downstream TCR signaling 70 4.51e-01 -0.052100 5.92e-01
Protein ubiquitination 71 4.49e-01 -0.052000 5.89e-01
Budding and maturation of HIV virion 28 6.36e-01 -0.051600 7.48e-01
APC/C-mediated degradation of cell cycle proteins 75 4.40e-01 0.051600 5.83e-01
Regulation of mitotic cell cycle 75 4.40e-01 0.051600 5.83e-01
The role of Nef in HIV-1 replication and disease pathogenesis 21 6.84e-01 -0.051400 7.92e-01
Arachidonate metabolism 33 6.10e-01 0.051300 7.27e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 7.09e-01 -0.050800 8.02e-01
TGFBR3 expression 21 6.89e-01 -0.050500 7.94e-01
Cyclin D associated events in G1 45 5.59e-01 -0.050300 6.88e-01
G1 Phase 45 5.59e-01 -0.050300 6.88e-01
Influenza Infection 152 2.85e-01 -0.050300 4.32e-01
Defective Intrinsic Pathway for Apoptosis 22 6.86e-01 -0.049700 7.93e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 25 6.69e-01 -0.049400 7.77e-01
TGF-beta receptor signaling activates SMADs 46 5.64e-01 -0.049200 6.90e-01
Degradation of beta-catenin by the destruction complex 72 4.72e-01 -0.049000 6.11e-01
Expression and translocation of olfactory receptors 21 6.98e-01 -0.048900 7.99e-01
RAC3 GTPase cycle 88 4.29e-01 -0.048800 5.72e-01
SARS-CoV-2-host interactions 175 2.68e-01 -0.048500 4.15e-01
trans-Golgi Network Vesicle Budding 70 4.84e-01 0.048400 6.21e-01
Hyaluronan metabolism 14 7.58e-01 -0.047700 8.40e-01
Unfolded Protein Response (UPR) 89 4.45e-01 0.046800 5.88e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 102 4.14e-01 0.046800 5.58e-01
PI3K events in ERBB2 signaling 12 7.79e-01 0.046800 8.58e-01
Transcriptional Regulation by MECP2 51 5.65e-01 0.046600 6.90e-01
Tie2 Signaling 16 7.49e-01 0.046300 8.33e-01
Cleavage of the damaged purine 24 6.96e-01 0.046200 7.99e-01
Depurination 24 6.96e-01 0.046200 7.99e-01
Recognition and association of DNA glycosylase with site containing an affected purine 24 6.96e-01 0.046200 7.99e-01
RNA Polymerase I Promoter Opening 19 7.29e-01 -0.046000 8.16e-01
STAT3 nuclear events downstream of ALK signaling 10 8.03e-01 -0.045700 8.77e-01
RHOC GTPase cycle 72 5.05e-01 -0.045500 6.37e-01
SCF(Skp2)-mediated degradation of p27/p21 50 5.82e-01 0.045100 7.04e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 25 6.98e-01 0.044800 7.99e-01
Trafficking of AMPA receptors 25 6.98e-01 0.044800 7.99e-01
PINK1-PRKN Mediated Mitophagy 31 6.67e-01 0.044600 7.75e-01
GAB1 signalosome 14 7.74e-01 0.044400 8.53e-01
GRB2 events in ERBB2 signaling 12 7.91e-01 -0.044200 8.68e-01
Processing and activation of SUMO 10 8.09e-01 -0.044200 8.80e-01
Dopamine Neurotransmitter Release Cycle 21 7.27e-01 -0.044100 8.14e-01
Inhibition of DNA recombination at telomere 35 6.52e-01 0.044100 7.61e-01
Synthesis of PIPs at the early endosome membrane 16 7.60e-01 0.044000 8.42e-01
Signaling by Leptin 10 8.10e-01 -0.044000 8.81e-01
Condensation of Prometaphase Chromosomes 11 8.01e-01 0.044000 8.75e-01
Interleukin-1 signaling 95 4.62e-01 -0.043700 6.01e-01
Regulation of lipid metabolism by PPARalpha 106 4.39e-01 -0.043500 5.83e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 6.84e-01 -0.042900 7.92e-01
PPARA activates gene expression 104 4.54e-01 -0.042500 5.94e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 190 3.18e-01 0.042000 4.65e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 6.87e-01 -0.041800 7.93e-01
Glutamate and glutamine metabolism 13 7.95e-01 0.041600 8.70e-01
FGFR1 mutant receptor activation 25 7.22e-01 -0.041200 8.12e-01
Degradation of GLI1 by the proteasome 46 6.31e-01 0.041000 7.44e-01
Condensation of Prophase Chromosomes 29 7.05e-01 -0.040700 8.01e-01
ERBB2 Regulates Cell Motility 11 8.16e-01 0.040500 8.84e-01
Transcriptional Regulation by NPAS4 29 7.07e-01 -0.040300 8.01e-01
Transcriptional regulation of brown and beige adipocyte differentiation 26 7.22e-01 -0.040300 8.12e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 26 7.22e-01 -0.040300 8.12e-01
Beta-catenin independent WNT signaling 122 4.46e-01 -0.039900 5.88e-01
Deubiquitination 230 2.98e-01 0.039800 4.47e-01
ALK mutants bind TKIs 12 8.12e-01 -0.039700 8.82e-01
Adipogenesis 99 5.01e-01 -0.039100 6.34e-01
RHOH GTPase cycle 33 6.98e-01 -0.039100 7.99e-01
Degradation of GLI2 by the proteasome 46 6.47e-01 0.039000 7.57e-01
Synthesis of IP3 and IP4 in the cytosol 22 7.53e-01 -0.038800 8.37e-01
Hedgehog ligand biogenesis 50 6.35e-01 0.038800 7.47e-01
IRF3-mediated induction of type I IFN 12 8.17e-01 0.038700 8.84e-01
SUMO E3 ligases SUMOylate target proteins 164 3.94e-01 0.038600 5.38e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 50 6.37e-01 -0.038600 7.48e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 7.24e-01 0.038600 8.12e-01
SUMOylation 170 3.87e-01 0.038400 5.35e-01
Factors involved in megakaryocyte development and platelet production 127 4.57e-01 -0.038200 5.97e-01
Infectious disease 864 5.91e-02 -0.037900 1.39e-01
Translesion synthesis by REV1 16 7.94e-01 0.037800 8.69e-01
Incretin synthesis, secretion, and inactivation 14 8.07e-01 -0.037700 8.79e-01
Metabolism of water-soluble vitamins and cofactors 110 4.94e-01 0.037700 6.30e-01
Regulation of PTEN stability and activity 56 6.33e-01 0.036900 7.46e-01
Regulation of TP53 Expression and Degradation 36 7.02e-01 -0.036900 8.01e-01
Receptor-type tyrosine-protein phosphatases 18 7.87e-01 -0.036800 8.66e-01
Potential therapeutics for SARS 82 5.71e-01 0.036200 6.95e-01
Response of EIF2AK1 (HRI) to heme deficiency 15 8.11e-01 -0.035600 8.82e-01
Diseases associated with glycosylation precursor biosynthesis 15 8.14e-01 -0.035000 8.83e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 8.27e-01 0.034900 8.92e-01
Carboxyterminal post-translational modifications of tubulin 32 7.33e-01 0.034900 8.18e-01
rRNA processing in the nucleus and cytosol 188 4.10e-01 0.034800 5.55e-01
Transcriptional regulation by RUNX2 101 5.47e-01 -0.034700 6.76e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 23 7.77e-01 0.034100 8.56e-01
PKR-mediated signaling 67 6.31e-01 0.033900 7.44e-01
SUMOylation of transcription cofactors 44 7.03e-01 -0.033200 8.01e-01
InlB-mediated entry of Listeria monocytogenes into host cell 15 8.30e-01 -0.032100 8.93e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 8.36e-01 -0.031900 8.98e-01
ATF6 (ATF6-alpha) activates chaperones 12 8.48e-01 -0.031900 9.06e-01
Negative regulation of MET activity 20 8.06e-01 -0.031700 8.79e-01
Maternal to zygotic transition (MZT) 70 6.49e-01 0.031500 7.57e-01
Antigen processing: Ubiquitination & Proteasome degradation 274 3.70e-01 0.031500 5.16e-01
PRC2 methylates histones and DNA 29 7.72e-01 0.031100 8.52e-01
Translesion synthesis by POLK 17 8.27e-01 0.030600 8.92e-01
Activation of gene expression by SREBF (SREBP) 42 7.34e-01 -0.030300 8.19e-01
GLI3 is processed to GLI3R by the proteasome 46 7.23e-01 0.030200 8.12e-01
Iron uptake and transport 53 7.06e-01 -0.030000 8.01e-01
Activated NTRK2 signals through FRS2 and FRS3 10 8.72e-01 0.029400 9.25e-01
G1/S DNA Damage Checkpoints 53 7.12e-01 0.029300 8.05e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 7.23e-01 0.029000 8.12e-01
Signaling by ERBB2 KD Mutants 21 8.19e-01 0.028900 8.85e-01
Insulin processing 21 8.23e-01 -0.028200 8.89e-01
Fatty acid metabolism 139 5.70e-01 0.027900 6.95e-01
RHO GTPases Activate Formins 130 5.83e-01 0.027900 7.04e-01
Phase I - Functionalization of compounds 62 7.05e-01 -0.027800 8.01e-01
Evasion by RSV of host interferon responses 21 8.33e-01 -0.026600 8.96e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 7.92e-01 -0.025800 8.68e-01
Phase II - Conjugation of compounds 68 7.13e-01 0.025800 8.05e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 8.59e-01 -0.025700 9.14e-01
Receptor Mediated Mitophagy 11 8.87e-01 0.024800 9.33e-01
RORA activates gene expression 18 8.55e-01 0.024800 9.12e-01
Kinesins 50 7.63e-01 -0.024600 8.44e-01
Attenuation phase 22 8.43e-01 0.024500 9.01e-01
Post-translational protein modification 1244 1.51e-01 -0.024300 2.82e-01
Hedgehog ‘off’ state 94 6.90e-01 0.023800 7.95e-01
FCERI mediated NF-kB activation 64 7.43e-01 -0.023700 8.28e-01
Degradation of cysteine and homocysteine 10 8.99e-01 0.023200 9.42e-01
XBP1(S) activates chaperone genes 45 7.89e-01 -0.023000 8.68e-01
ESR-mediated signaling 165 6.11e-01 -0.023000 7.27e-01
Regulation of KIT signaling 14 8.82e-01 0.022900 9.29e-01
Regulation of MITF-M-dependent genes involved in pigmentation 38 8.08e-01 0.022800 8.80e-01
G1/S-Specific Transcription 29 8.34e-01 0.022500 8.96e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 8.82e-01 -0.022200 9.29e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 8.82e-01 -0.022200 9.29e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 8.82e-01 -0.022200 9.29e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 8.82e-01 -0.022200 9.29e-01
Signaling by CTNNB1 phospho-site mutants 15 8.82e-01 -0.022200 9.29e-01
Signaling by GSK3beta mutants 15 8.82e-01 -0.022200 9.29e-01
MITF-M-dependent gene expression 99 7.03e-01 0.022200 8.01e-01
Cellular response to hypoxia 59 7.69e-01 0.022100 8.50e-01
Nucleotide catabolism 28 8.41e-01 0.022000 9.00e-01
Interleukin-20 family signaling 18 8.75e-01 -0.021400 9.28e-01
Transcriptional Regulation by VENTX 37 8.23e-01 -0.021300 8.89e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 7.54e-01 -0.021100 8.37e-01
Selective autophagy 78 7.55e-01 0.020500 8.38e-01
Transcriptional regulation by RUNX1 164 6.53e-01 -0.020400 7.61e-01
MHC class II antigen presentation 103 7.21e-01 -0.020300 8.12e-01
Listeria monocytogenes entry into host cells 19 8.81e-01 -0.019800 9.29e-01
Aflatoxin activation and detoxification 13 9.04e-01 -0.019400 9.45e-01
RHO GTPases activate PAKs 21 8.78e-01 -0.019300 9.29e-01
Bacterial Infection Pathways 64 7.91e-01 -0.019200 8.68e-01
Negative regulation of FGFR1 signaling 25 8.71e-01 -0.018800 9.25e-01
Macroautophagy 130 7.12e-01 0.018800 8.05e-01
Signaling by ERBB2 ECD mutants 15 9.00e-01 0.018700 9.43e-01
Transcriptional Regulation by E2F6 34 8.52e-01 0.018500 9.09e-01
SIRT1 negatively regulates rRNA expression 24 8.75e-01 -0.018500 9.28e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 8.48e-01 0.018500 9.06e-01
Respiratory Syncytial Virus Infection Pathway 101 7.54e-01 0.018100 8.37e-01
GABA synthesis, release, reuptake and degradation 14 9.08e-01 -0.017900 9.48e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.02e-01 0.017800 9.44e-01
MITF-M-regulated melanocyte development 140 7.23e-01 0.017300 8.12e-01
Major pathway of rRNA processing in the nucleolus and cytosol 178 7.00e-01 0.016800 8.00e-01
Signaling by FGFR2 in disease 34 8.66e-01 0.016800 9.21e-01
Serotonin Neurotransmitter Release Cycle 16 9.10e-01 0.016400 9.48e-01
G beta:gamma signalling through CDC42 16 9.14e-01 -0.015600 9.50e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 8.41e-01 -0.015600 9.00e-01
Formation of paraxial mesoderm 56 8.41e-01 -0.015500 9.00e-01
PTEN Regulation 129 7.64e-01 0.015300 8.44e-01
Metabolism of proteins 1765 2.89e-01 0.015300 4.37e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 71 8.28e-01 -0.014900 8.93e-01
Vesicle-mediated transport 596 5.37e-01 -0.014800 6.68e-01
Reproduction 86 8.12e-01 -0.014800 8.82e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 9.14e-01 0.014700 9.50e-01
VLDLR internalisation and degradation 15 9.22e-01 0.014500 9.55e-01
MAPK6/MAPK4 signaling 75 8.30e-01 -0.014300 8.94e-01
Hedgehog ‘on’ state 71 8.41e-01 0.013800 9.00e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 8.70e-01 -0.013600 9.25e-01
Clathrin-mediated endocytosis 131 7.91e-01 -0.013400 8.68e-01
Glutathione conjugation 27 9.06e-01 0.013200 9.46e-01
Glycolysis 64 8.59e-01 0.012900 9.14e-01
Transferrin endocytosis and recycling 27 9.09e-01 0.012800 9.48e-01
Signaling by Hedgehog 129 8.04e-01 -0.012700 8.78e-01
Regulation of TP53 Degradation 35 8.97e-01 -0.012600 9.41e-01
Signaling by NTRK2 (TRKB) 23 9.22e-01 -0.011800 9.55e-01
Metabolism of vitamins and cofactors 163 7.96e-01 -0.011700 8.71e-01
Regulation of pyruvate metabolism 32 9.11e-01 -0.011400 9.49e-01
p53-Dependent G1 DNA Damage Response 51 8.89e-01 0.011300 9.34e-01
p53-Dependent G1/S DNA damage checkpoint 51 8.89e-01 0.011300 9.34e-01
Viral Infection Pathways 700 6.16e-01 -0.011200 7.32e-01
Regulation of RAS by GAPs 53 8.90e-01 0.010900 9.35e-01
Xenobiotics 12 9.50e-01 0.010500 9.72e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 9.19e-01 0.010400 9.53e-01
Lysosphingolipid and LPA receptors 11 9.53e-01 0.010300 9.73e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 8.92e-01 -0.010200 9.36e-01
APC truncation mutants have impaired AXIN binding 14 9.47e-01 0.010200 9.71e-01
AXIN missense mutants destabilize the destruction complex 14 9.47e-01 0.010200 9.71e-01
Signaling by AMER1 mutants 14 9.47e-01 0.010200 9.71e-01
Signaling by APC mutants 14 9.47e-01 0.010200 9.71e-01
Signaling by AXIN mutants 14 9.47e-01 0.010200 9.71e-01
Truncations of AMER1 destabilize the destruction complex 14 9.47e-01 0.010200 9.71e-01
Platelet sensitization by LDL 14 9.48e-01 -0.010000 9.71e-01
Membrane Trafficking 578 6.82e-01 -0.009990 7.90e-01
Presynaptic function of Kainate receptors 16 9.46e-01 -0.009840 9.71e-01
Cellular responses to stress 697 6.61e-01 0.009750 7.70e-01
MECP2 regulates neuronal receptors and channels 16 9.49e-01 -0.009240 9.71e-01
Synthesis of PIPs at the Golgi membrane 15 9.51e-01 -0.009240 9.72e-01
Biological oxidations 134 8.58e-01 0.008940 9.14e-01
APC-Cdc20 mediated degradation of Nek2A 26 9.39e-01 0.008740 9.68e-01
IRE1alpha activates chaperones 47 9.22e-01 -0.008300 9.55e-01
Asparagine N-linked glycosylation 281 8.15e-01 -0.008140 8.83e-01
Cellular responses to stimuli 792 6.98e-01 -0.008120 7.99e-01
Metabolism 1783 5.86e-01 0.007810 7.04e-01
ABC transporter disorders 59 9.18e-01 -0.007780 9.53e-01
Long-term potentiation 18 9.58e-01 0.007110 9.77e-01
Chaperonin-mediated protein folding 80 9.14e-01 -0.006990 9.50e-01
Metabolism of amino acids and derivatives 294 8.38e-01 0.006930 9.00e-01
Disorders of transmembrane transporters 127 9.04e-01 -0.006180 9.45e-01
RHOG GTPase cycle 73 9.28e-01 -0.006150 9.59e-01
Peroxisomal protein import 57 9.38e-01 0.006000 9.68e-01
Class I peroxisomal membrane protein import 19 9.64e-01 0.005990 9.78e-01
Protein folding 86 9.24e-01 0.005980 9.56e-01
Signaling by ERBB2 in Cancer 22 9.62e-01 0.005920 9.78e-01
Negative regulation of FGFR3 signaling 23 9.64e-01 -0.005430 9.78e-01
Cargo recognition for clathrin-mediated endocytosis 91 9.30e-01 -0.005310 9.61e-01
Regulation of NF-kappa B signaling 18 9.70e-01 0.005100 9.82e-01
Glucose metabolism 70 9.41e-01 0.005080 9.71e-01
Formation of apoptosome 11 9.78e-01 -0.004900 9.87e-01
Regulation of the apoptosome activity 11 9.78e-01 -0.004900 9.87e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 50 9.52e-01 0.004890 9.73e-01
SLC transporter disorders 68 9.46e-01 -0.004750 9.71e-01
Transport to the Golgi and subsequent modification 166 9.16e-01 -0.004750 9.52e-01
Signaling by PDGFR in disease 19 9.72e-01 -0.004690 9.83e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.61e-01 -0.004660 9.78e-01
ABC-family proteins mediated transport 82 9.44e-01 -0.004520 9.71e-01
Metalloprotease DUBs 23 9.73e-01 -0.004090 9.83e-01
RSV-host interactions 79 9.54e-01 -0.003740 9.73e-01
Pyruvate metabolism 43 9.66e-01 0.003720 9.79e-01
Activation of NF-kappaB in B cells 53 9.64e-01 0.003610 9.78e-01
Diseases of programmed cell death 57 9.65e-01 -0.003350 9.79e-01
Activation of HOX genes during differentiation 77 9.62e-01 -0.003120 9.78e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 77 9.62e-01 -0.003120 9.78e-01
Packaging Of Telomere Ends 20 9.87e-01 -0.002160 9.93e-01
Signaling by FGFR in disease 54 9.78e-01 0.002160 9.87e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 119 9.70e-01 -0.001980 9.82e-01
Diseases of mitotic cell cycle 38 9.86e-01 0.001630 9.93e-01
Cargo trafficking to the periciliary membrane 46 9.85e-01 -0.001620 9.92e-01
Autophagy 143 9.85e-01 0.000941 9.92e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 21 9.94e-01 -0.000907 1.00e+00
DNA Damage/Telomere Stress Induced Senescence 45 9.95e-01 -0.000531 1.00e+00
Purine catabolism 15 9.97e-01 0.000471 1.00e+00
p130Cas linkage to MAPK signaling for integrins 11 9.98e-01 0.000363 1.00e+00
Intra-Golgi traffic 43 9.97e-01 0.000317 1.00e+00
Negative regulation of FGFR4 signaling 23 9.98e-01 0.000298 1.00e+00
Interleukin-6 signaling 11 9.99e-01 0.000242 1.00e+00
Signaling by FGFR2 62 9.99e-01 0.000137 1.00e+00
Class I MHC mediated antigen processing & presentation 334 1.00e+00 -0.000015 1.00e+00


Detailed Gene set reports



HDR through MMEJ (alt-NHEJ)
set HDR through MMEJ (alt-NHEJ)
setSize 12
pANOVA 0.000196
s.dist 0.621
p.adjustANOVA 0.0022


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD50 10438
XRCC1 10380
RAD52 9223
RBBP8 9058
NBN 8629
LIG3 8467
PARP2 7655
BRCA2 6309
MRE11 5964
POLQ 5787
FEN1 2034
PARP1 -1295

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All member genes
GeneID Gene Rank
RAD50 10438
XRCC1 10380
RAD52 9223
RBBP8 9058
NBN 8629
LIG3 8467
PARP2 7655
BRCA2 6309
MRE11 5964
POLQ 5787
FEN1 2034
PARP1 -1295


Complex III assembly
set Complex III assembly
setSize 25
pANOVA 1.7e-07
s.dist 0.604
p.adjustANOVA 6.63e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
NFS1 10456
UQCRC2 10297
LETM1 9826
LYRM7 9612
UQCRH 9509
UQCC2 9359
UQCRB 9199
HSPA9 9183
UQCC5 8933
CYC1 8761
UQCRFS1 8248
BCS1L 8215
UQCR10 7995
UQCRQ 7901
ISCU 7552
UQCC1 7537
UQCC6 6416
UQCR11 5648
UQCRC1 5553
FXN 5500

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All member genes
GeneID Gene Rank
NFS1 10456
UQCRC2 10297
LETM1 9826
LYRM7 9612
UQCRH 9509
UQCC2 9359
UQCRB 9199
HSPA9 9183
UQCC5 8933
CYC1 8761
UQCRFS1 8248
BCS1L 8215
UQCR10 7995
UQCRQ 7901
ISCU 7552
UQCC1 7537
UQCC6 6416
UQCR11 5648
UQCRC1 5553
FXN 5500
MT-CYB 3888
UQCC3 3690
TTC19 3552
LYRM4 -2822
HSCB -6005


NOTCH4 Activation and Transmission of Signal to the Nucleus
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 11
pANOVA 0.000578
s.dist -0.599
p.adjustANOVA 0.0049


Top enriched genes
Top 20 genes
GeneID Gene Rank
ADAM10 -8130
APH1B -8111
NCSTN -6991
NOTCH4 -6409
DLL4 -6064
APH1A -6039
PSEN2 -4884
PSEN1 -3935
YWHAZ -2443
JAG1 -2317
PSENEN 4

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All member genes
GeneID Gene Rank
ADAM10 -8130
APH1B -8111
NCSTN -6991
NOTCH4 -6409
DLL4 -6064
APH1A -6039
PSEN2 -4884
PSEN1 -3935
YWHAZ -2443
JAG1 -2317
PSENEN 4


TNFs bind their physiological receptors
set TNFs bind their physiological receptors
setSize 15
pANOVA 6.74e-05
s.dist -0.594
p.adjustANOVA 0.00091


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNFRSF1B -8929
TNFSF9 -8806
CD70 -8443
TNFRSF1A -8233
TNFRSF11B -8226
EDARADD -7595
TNFRSF6B -7468
TNFSF13B -6964
TNFRSF14 -6360
TNFSF4 -6214
TNFRSF9 -4474
LTA -3011
TNFRSF25 1542
TNFSF13 2627
EDA 5876

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All member genes
GeneID Gene Rank
TNFRSF1B -8929
TNFSF9 -8806
CD70 -8443
TNFRSF1A -8233
TNFRSF11B -8226
EDARADD -7595
TNFRSF6B -7468
TNFSF13B -6964
TNFRSF14 -6360
TNFSF4 -6214
TNFRSF9 -4474
LTA -3011
TNFRSF25 1542
TNFSF13 2627
EDA 5876


TP53 Regulates Transcription of Death Receptors and Ligands
set TP53 Regulates Transcription of Death Receptors and Ligands
setSize 11
pANOVA 0.000683
s.dist -0.591
p.adjustANOVA 0.00537


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNFRSF10A -8483
FAS -8380
TNFRSF10D -7296
TNFRSF10B -6622
IGFBP3 -6549
TP53BP2 -6228
TNFRSF10C -4992
TMEM219 -4149
PPP1R13B -4012
TP73 -1123
TP53 3364

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All member genes
GeneID Gene Rank
TNFRSF10A -8483
FAS -8380
TNFRSF10D -7296
TNFRSF10B -6622
IGFBP3 -6549
TP53BP2 -6228
TNFRSF10C -4992
TMEM219 -4149
PPP1R13B -4012
TP73 -1123
TP53 3364


Dissolution of Fibrin Clot
set Dissolution of Fibrin Clot
setSize 11
pANOVA 0.00101
s.dist -0.573
p.adjustANOVA 0.00694


Top enriched genes
Top 20 genes
GeneID Gene Rank
S100A10 -8662
SERPINF2 -8347
PLAT -7943
SERPINB8 -6863
SERPINB2 -6498
PLAU -5036
PLAUR -4644
ANXA2 -4517
SERPINB6 -4399
SERPINE2 2013
SERPINE1 2437

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All member genes
GeneID Gene Rank
S100A10 -8662
SERPINF2 -8347
PLAT -7943
SERPINB8 -6863
SERPINB2 -6498
PLAU -5036
PLAUR -4644
ANXA2 -4517
SERPINB6 -4399
SERPINE2 2013
SERPINE1 2437


Regulated proteolysis of p75NTR
set Regulated proteolysis of p75NTR
setSize 11
pANOVA 0.00136
s.dist -0.558
p.adjustANOVA 0.00893


Top enriched genes
Top 20 genes
GeneID Gene Rank
APH1B -8111
NCSTN -6991
NFKB1 -6828
ADAM17 -6149
APH1A -6039
RELA -6009
PSEN2 -4884
PSEN1 -3935
TRAF6 -3141
PSENEN 4
NGFR 1250

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APH1B -8111
NCSTN -6991
NFKB1 -6828
ADAM17 -6149
APH1A -6039
RELA -6009
PSEN2 -4884
PSEN1 -3935
TRAF6 -3141
PSENEN 4
NGFR 1250


Plasma lipoprotein remodeling
set Plasma lipoprotein remodeling
setSize 16
pANOVA 0.000128
s.dist -0.553
p.adjustANOVA 0.00157


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLTP -8830
LIPG -8769
ANGPTL4 -8442
LPL -8420
APOE -7592
MBTPS1 -7561
LMF2 -6568
LMF1 -6516
PCSK6 -6150
ABCG1 -5949
FURIN -5673
MBTPS2 -4146
LCAT -2375
PCSK5 2830
P4HB 5477
MTTP 5486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLTP -8830
LIPG -8769
ANGPTL4 -8442
LPL -8420
APOE -7592
MBTPS1 -7561
LMF2 -6568
LMF1 -6516
PCSK6 -6150
ABCG1 -5949
FURIN -5673
MBTPS2 -4146
LCAT -2375
PCSK5 2830
P4HB 5477
MTTP 5486


Endosomal/Vacuolar pathway
set Endosomal/Vacuolar pathway
setSize 11
pANOVA 0.00152
s.dist -0.552
p.adjustANOVA 0.00979


Top enriched genes
Top 20 genes
GeneID Gene Rank
B2M -8809
CTSS -8492
HLA-A -8078
HLA-B -7110
HLA-C -6722
HLA-E -6679
CTSL -6560
HLA-F -6422
HLA-H -5505
CTSV 5179
LNPEP 8951

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B2M -8809
CTSS -8492
HLA-A -8078
HLA-B -7110
HLA-C -6722
HLA-E -6679
CTSL -6560
HLA-F -6422
HLA-H -5505
CTSV 5179
LNPEP 8951


FASTK family proteins regulate processing and stability of mitochondrial RNAs
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 19
pANOVA 3.95e-05
s.dist 0.545
p.adjustANOVA 0.000605


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP8 10139
MT-ATP6 9901
MT-ND3 9827
MT-ND2 9631
MT-ND1 9352
MT-ND4L 8578
MT-CO3 8348
MT-ND4 7786
FASTKD2 6255
MT-RNR1 6027
MT-ND5 5935
MT-ND6 5504
MT-CO1 5389
FASTKD5 5166
FASTK 4278
MT-CYB 3888
MT-RNR2 2991
MT-CO2 819
TBRG4 -3128

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP8 10139
MT-ATP6 9901
MT-ND3 9827
MT-ND2 9631
MT-ND1 9352
MT-ND4L 8578
MT-CO3 8348
MT-ND4 7786
FASTKD2 6255
MT-RNR1 6027
MT-ND5 5935
MT-ND6 5504
MT-CO1 5389
FASTKD5 5166
FASTK 4278
MT-CYB 3888
MT-RNR2 2991
MT-CO2 819
TBRG4 -3128


Chondroitin sulfate biosynthesis
set Chondroitin sulfate biosynthesis
setSize 18
pANOVA 6.91e-05
s.dist -0.542
p.adjustANOVA 0.000917


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHST15 -8921
BGN -8467
CHSY1 -8285
CHST13 -7867
CHST7 -7125
CHST3 -7119
CHST11 -7014
CSGALNACT1 -6014
CSPG5 -5475
CHPF2 -5415
VCAN -5392
CHST9 -3965
CSGALNACT2 -3698
CHST12 -2689
CHPF -1293
BCAN -364
CSPG4 676
CHSY3 8060

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All member genes
GeneID Gene Rank
CHST15 -8921
BGN -8467
CHSY1 -8285
CHST13 -7867
CHST7 -7125
CHST3 -7119
CHST11 -7014
CSGALNACT1 -6014
CSPG5 -5475
CHPF2 -5415
VCAN -5392
CHST9 -3965
CSGALNACT2 -3698
CHST12 -2689
CHPF -1293
BCAN -364
CSPG4 676
CHSY3 8060


Phase 4 - resting membrane potential
set Phase 4 - resting membrane potential
setSize 13
pANOVA 0.000908
s.dist -0.531
p.adjustANOVA 0.00651


Top enriched genes
Top 20 genes
GeneID Gene Rank
KCNJ12 -8346
KCNK13 -7895
KCNK5 -7788
KCNK1 -7555
KCNK9 -7353
KCNK10 -7157
KCNJ4 -7068
KCNK3 -6215
KCNK12 -1450
KCNK6 -1322
KCNJ14 1118
KCNK2 1682
KCNJ2 2600

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All member genes
GeneID Gene Rank
KCNJ12 -8346
KCNK13 -7895
KCNK5 -7788
KCNK1 -7555
KCNK9 -7353
KCNK10 -7157
KCNJ4 -7068
KCNK3 -6215
KCNK12 -1450
KCNK6 -1322
KCNJ14 1118
KCNK2 1682
KCNJ2 2600


Formation of ATP by chemiosmotic coupling
set Formation of ATP by chemiosmotic coupling
setSize 20
pANOVA 6.92e-05
s.dist 0.514
p.adjustANOVA 0.000917


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5PO 10346
MT-ATP8 10139
MT-ATP6 9901
ATP5F1A 8911
ATP5MC2 8648
ATP5PD 8309
ATP5PF 8183
ATP5ME 8055
ATP5MC1 7771
ATP5F1B 7663
ATP5MG 5253
ATP5MJ 4915
ATP5MF 4909
ATP5MK 4794
DMAC2L 4299
ATP5F1E 3276
ATP5MC3 3006
ATP5F1C 1182
ATP5F1D -201
ATP5PB -2540

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5PO 10346
MT-ATP8 10139
MT-ATP6 9901
ATP5F1A 8911
ATP5MC2 8648
ATP5PD 8309
ATP5PF 8183
ATP5ME 8055
ATP5MC1 7771
ATP5F1B 7663
ATP5MG 5253
ATP5MJ 4915
ATP5MF 4909
ATP5MK 4794
DMAC2L 4299
ATP5F1E 3276
ATP5MC3 3006
ATP5F1C 1182
ATP5F1D -201
ATP5PB -2540


Cristae formation
set Cristae formation
setSize 33
pANOVA 3.49e-07
s.dist 0.512
p.adjustANOVA 1.26e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTX2 10551
ATP5PO 10346
MT-ATP8 10139
MT-ATP6 9901
APOOL 9438
HSPA9 9183
ATP5F1A 8911
ATP5MC2 8648
MICOS13 8473
CHCHD3 8317
ATP5PD 8309
ATP5PF 8183
ATP5ME 8055
MICOS10 7999
DNAJC11 7886
ATP5MC1 7771
ATP5F1B 7663
SAMM50 6743
CHCHD6 6638
ATP5MG 5253

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTX2 10551
ATP5PO 10346
MT-ATP8 10139
MT-ATP6 9901
APOOL 9438
HSPA9 9183
ATP5F1A 8911
ATP5MC2 8648
MICOS13 8473
CHCHD3 8317
ATP5PD 8309
ATP5PF 8183
ATP5ME 8055
MICOS10 7999
DNAJC11 7886
ATP5MC1 7771
ATP5F1B 7663
SAMM50 6743
CHCHD6 6638
ATP5MG 5253
IMMT 5176
ATP5MJ 4915
ATP5MF 4909
ATP5MK 4794
DMAC2L 4299
ATP5F1E 3276
ATP5MC3 3006
TMEM11 1967
ATP5F1C 1182
APOO 25
ATP5F1D -201
ATP5PB -2540
MTX1 -7079


TGFBR3 PTM regulation
set TGFBR3 PTM regulation
setSize 11
pANOVA 0.00358
s.dist -0.507
p.adjustANOVA 0.0178


Top enriched genes
Top 20 genes
GeneID Gene Rank
TIMP1 -8390
APH1B -8111
TIMP2 -7701
NCSTN -6991
APH1A -6039
TGFBR3 -5653
PSEN2 -4884
PSEN1 -3935
MMP14 -3363
PSENEN 4
MMP16 9632

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TIMP1 -8390
APH1B -8111
TIMP2 -7701
NCSTN -6991
APH1A -6039
TGFBR3 -5653
PSEN2 -4884
PSEN1 -3935
MMP14 -3363
PSENEN 4
MMP16 9632


Complex I biogenesis
set Complex I biogenesis
setSize 66
pANOVA 1.31e-12
s.dist 0.505
p.adjustANOVA 1.34e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFA10 10465
TMEM186 10152
MT-ND3 9827
NDUFAF2 9675
MT-ND2 9631
NDUFAF1 9613
NDUFV1 9591
NDUFS4 9541
NDUFS7 9385
MT-ND1 9352
NDUFS6 9290
NDUFS8 9259
NDUFB5 9253
HSPA9 9183
NDUFAF6 9110
NDUFAF5 9077
FOXRED1 8987
NDUFA9 8793
NDUFA2 8620
TMEM126A 8452

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA10 10465.0
TMEM186 10152.0
MT-ND3 9827.0
NDUFAF2 9675.0
MT-ND2 9631.0
NDUFAF1 9613.0
NDUFV1 9591.0
NDUFS4 9541.0
NDUFS7 9385.0
MT-ND1 9352.0
NDUFS6 9290.0
NDUFS8 9259.0
NDUFB5 9253.0
HSPA9 9183.0
NDUFAF6 9110.0
NDUFAF5 9077.0
FOXRED1 8987.0
NDUFA9 8793.0
NDUFA2 8620.0
TMEM126A 8452.0
NDUFB6 8356.0
NDUFV2 8330.0
NDUFAF7 8329.0
NDUFA8 8234.0
NDUFB3 7976.0
ECSIT 7890.0
MT-ND4 7786.0
NDUFS3 7743.0
NDUFA3 7412.0
NDUFB9 7384.0
NDUFA1 7285.0
NDUFS5 7230.0
NDUFS1 6875.0
NDUFA12 6459.0
NDUFA7 6417.0
NDUFB7 6314.0
NDUFAB1 6152.0
TMEM126B 6036.0
NDUFAF8 5937.0
MT-ND5 5935.0
SFXN4 5616.0
MT-ND6 5504.0
NDUFA6 5460.0
NDUFB10 5310.0
TIMMDC1 4866.0
NDUFB1 4689.0
NDUFV3 4562.0
NDUFC2 4550.0
NDUFS2 4276.0
NDUFA13 4218.0
NDUFA5 3461.0
NDUFC1 3238.0
NDUFAF3 3047.0
NDUFAF4 2078.0
NDUFB2 1872.0
ACAD9 1529.0
NDUFA11 1084.0
COA1 932.0
PYURF 312.5
OXA1L -353.0
NDUFB8 -1774.0
NDUFB11 -2406.0
NUBPL -2499.0
NDUFB4 -2645.0
LYRM2 -3500.0
HSCB -6005.0


Mitochondrial RNA degradation
set Mitochondrial RNA degradation
setSize 25
pANOVA 1.65e-05
s.dist 0.498
p.adjustANOVA 0.000314


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ATP8 10139
MT-ATP6 9901
MT-ND3 9827
MT-ND2 9631
MT-ND1 9352
MT-ND4L 8578
MT-CO3 8348
MT-ND4 7786
LRPPRC 7347
REXO2 7213
SLIRP 6754
FASTKD2 6255
MT-RNR1 6027
MT-ND5 5935
MT-ND6 5504
MT-CO1 5389
FASTKD5 5166
FASTK 4278
MT-CYB 3888
MT-RNR2 2991

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP8 10139
MT-ATP6 9901
MT-ND3 9827
MT-ND2 9631
MT-ND1 9352
MT-ND4L 8578
MT-CO3 8348
MT-ND4 7786
LRPPRC 7347
REXO2 7213
SLIRP 6754
FASTKD2 6255
MT-RNR1 6027
MT-ND5 5935
MT-ND6 5504
MT-CO1 5389
FASTKD5 5166
FASTK 4278
MT-CYB 3888
MT-RNR2 2991
PNPT1 1966
SUPV3L1 1896
MT-CO2 819
GRSF1 163
TBRG4 -3128


The canonical retinoid cycle in rods (twilight vision)
set The canonical retinoid cycle in rods (twilight vision)
setSize 12
pANOVA 0.00318
s.dist -0.492
p.adjustANOVA 0.0165


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBP1 -8576
STRA6 -8273
RLBP1 -8046
MYO7A -7186
RDH11 -6733
RBP4 -6399
CYP4V2 -4648
RDH10 -3778
RDH5 -3053
ABCA4 1235
HSD17B6 3114
RDH16 4607

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBP1 -8576
STRA6 -8273
RLBP1 -8046
MYO7A -7186
RDH11 -6733
RBP4 -6399
CYP4V2 -4648
RDH10 -3778
RDH5 -3053
ABCA4 1235
HSD17B6 3114
RDH16 4607


Killing mechanisms
set Killing mechanisms
setSize 11
pANOVA 0.00475
s.dist -0.492
p.adjustANOVA 0.0212


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYBA -8818
RAC1 -8329
MAPK8 -7983
DVL3 -7763
WNT5A -6040
NOXA1 -5350
FZD7 -5266
NOX1 -3437
DVL1 -2802
JUN 3177
DVL2 8854

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All member genes
GeneID Gene Rank
CYBA -8818
RAC1 -8329
MAPK8 -7983
DVL3 -7763
WNT5A -6040
NOXA1 -5350
FZD7 -5266
NOX1 -3437
DVL1 -2802
JUN 3177
DVL2 8854


WNT5:FZD7-mediated leishmania damping
set WNT5:FZD7-mediated leishmania damping
setSize 11
pANOVA 0.00475
s.dist -0.492
p.adjustANOVA 0.0212


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYBA -8818
RAC1 -8329
MAPK8 -7983
DVL3 -7763
WNT5A -6040
NOXA1 -5350
FZD7 -5266
NOX1 -3437
DVL1 -2802
JUN 3177
DVL2 8854

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYBA -8818
RAC1 -8329
MAPK8 -7983
DVL3 -7763
WNT5A -6040
NOXA1 -5350
FZD7 -5266
NOX1 -3437
DVL1 -2802
JUN 3177
DVL2 8854


Specification of primordial germ cells
set Specification of primordial germ cells
setSize 10
pANOVA 0.00723
s.dist -0.491
p.adjustANOVA 0.0287


Top enriched genes
Top 20 genes
GeneID Gene Rank
CXCR4 -8050
PRDM1 -7820
BMP4 -7776
SOX17 -6367
TET2 -5932
PDPN -4422
NANOS3 -4094
EOMES -1855
CBFA2T2 21
TFAP2C 6625

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CXCR4 -8050
PRDM1 -7820
BMP4 -7776
SOX17 -6367
TET2 -5932
PDPN -4422
NANOS3 -4094
EOMES -1855
CBFA2T2 21
TFAP2C 6625


Maturation of nucleoprotein_9683610
set Maturation of nucleoprotein_9683610
setSize 11
pANOVA 0.00488
s.dist -0.49
p.adjustANOVA 0.0216


Top enriched genes
Top 20 genes
GeneID Gene Rank
PARP9 -7117
PARP10 -6573
PARP4 -6195
PARP6 -5863
PARP14 -5566
UBE2I -4242
GSK3B -3074
PARP16 -2637
PARP8 -2467
GSK3A -2104
SUMO1 2245

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARP9 -7117
PARP10 -6573
PARP4 -6195
PARP6 -5863
PARP14 -5566
UBE2I -4242
GSK3B -3074
PARP16 -2637
PARP8 -2467
GSK3A -2104
SUMO1 2245


Cytosolic tRNA aminoacylation
set Cytosolic tRNA aminoacylation
setSize 24
pANOVA 3.37e-05
s.dist 0.489
p.adjustANOVA 0.000529


Top enriched genes
Top 20 genes
GeneID Gene Rank
NARS1 10495
RARS1 10284
YARS1 9863
KARS1 9267
LARS1 8950
HARS1 8733
IARS1 8644
WARS1 8579
EPRS1 8230
MARS1 7881
AARS1 6648
FARSB 6554
FARSA 6242
GARS1 5445
VARS1 5099
AIMP1 4558
QARS1 3771
CARS1 3710
AIMP2 3513
EEF1E1 3432

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NARS1 10495
RARS1 10284
YARS1 9863
KARS1 9267
LARS1 8950
HARS1 8733
IARS1 8644
WARS1 8579
EPRS1 8230
MARS1 7881
AARS1 6648
FARSB 6554
FARSA 6242
GARS1 5445
VARS1 5099
AIMP1 4558
QARS1 3771
CARS1 3710
AIMP2 3513
EEF1E1 3432
TARS1 3272
PPA1 1810
SARS1 -3222
DARS1 -7438


CS/DS degradation
set CS/DS degradation
setSize 12
pANOVA 0.00337
s.dist -0.489
p.adjustANOVA 0.017


Top enriched genes
Top 20 genes
GeneID Gene Rank
BGN -8467
IDS -8340
HEXA -7073
HYAL1 -6067
CSPG5 -5475
VCAN -5392
ARSB -2850
HYAL3 -2126
IDUA -1701
BCAN -364
HEXB -213
CSPG4 676

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN -8467
IDS -8340
HEXA -7073
HYAL1 -6067
CSPG5 -5475
VCAN -5392
ARSB -2850
HYAL3 -2126
IDUA -1701
BCAN -364
HEXB -213
CSPG4 676


Nucleotide biosynthesis
set Nucleotide biosynthesis
setSize 12
pANOVA 0.00346
s.dist 0.487
p.adjustANOVA 0.0174


Top enriched genes
Top 20 genes
GeneID Gene Rank
GART 10134
PFAS 9327
PPAT 8964
DHODH 8206
CAD 8028
ATIC 7865
IMPDH2 7837
PAICS 5536
GMPS 4749
UMPS 3435
ADSL -1483
IMPDH1 -5582

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GART 10134
PFAS 9327
PPAT 8964
DHODH 8206
CAD 8028
ATIC 7865
IMPDH2 7837
PAICS 5536
GMPS 4749
UMPS 3435
ADSL -1483
IMPDH1 -5582


Glycosphingolipid biosynthesis
set Glycosphingolipid biosynthesis
setSize 18
pANOVA 0.000594
s.dist -0.468
p.adjustANOVA 0.00497


Top enriched genes
Top 20 genes
GeneID Gene Rank
B3GNT5 -8790
B3GALNT1 -8709
ST3GAL2 -8689
B4GALT5 -8379
ST6GALNAC5 -7671
A4GALT -7340
B4GALNT1 -6829
FUT1 -5997
UGCG -5557
ST6GALNAC6 -5508
ST3GAL5 -4353
B3GALT4 -3999
ST3GAL3 -2898
CERK -1205
UGT8 1626
FUT2 3182
ST8SIA5 5757
B4GALT6 8026

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3GNT5 -8790
B3GALNT1 -8709
ST3GAL2 -8689
B4GALT5 -8379
ST6GALNAC5 -7671
A4GALT -7340
B4GALNT1 -6829
FUT1 -5997
UGCG -5557
ST6GALNAC6 -5508
ST3GAL5 -4353
B3GALT4 -3999
ST3GAL3 -2898
CERK -1205
UGT8 1626
FUT2 3182
ST8SIA5 5757
B4GALT6 8026


WNT ligand biogenesis and trafficking
set WNT ligand biogenesis and trafficking
setSize 19
pANOVA 0.000492
s.dist -0.462
p.adjustANOVA 0.00439


Top enriched genes
Top 20 genes
GeneID Gene Rank
WNT7B -8702
SNX3 -8327
WNT6 -8149
WNT11 -6976
VPS26A -6645
WNT3 -6593
WNT5A -6040
VPS35 -4921
TMED5 -4544
WLS -4317
WNT9A -4031
WNT2B -3970
WNT10A -3405
WNT4 -3393
WNT7A -2545
PORCN -131
VPS29 956
WNT5B 4963
WNT10B 6765

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT7B -8702
SNX3 -8327
WNT6 -8149
WNT11 -6976
VPS26A -6645
WNT3 -6593
WNT5A -6040
VPS35 -4921
TMED5 -4544
WLS -4317
WNT9A -4031
WNT2B -3970
WNT10A -3405
WNT4 -3393
WNT7A -2545
PORCN -131
VPS29 956
WNT5B 4963
WNT10B 6765


Negative regulation of TCF-dependent signaling by WNT ligand antagonists
set Negative regulation of TCF-dependent signaling by WNT ligand antagonists
setSize 10
pANOVA 0.012
s.dist -0.459
p.adjustANOVA 0.0428


Top enriched genes
Top 20 genes
GeneID Gene Rank
KREMEN1 -7613
DKK2 -7421
LRP5 -7415
SFRP1 -7161
WNT5A -6040
WNT9A -4031
KREMEN2 -3470
WNT4 -3393
LRP6 434
DKK1 9519

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KREMEN1 -7613
DKK2 -7421
LRP5 -7415
SFRP1 -7161
WNT5A -6040
WNT9A -4031
KREMEN2 -3470
WNT4 -3393
LRP6 434
DKK1 9519


Termination of O-glycan biosynthesis
set Termination of O-glycan biosynthesis
setSize 12
pANOVA 0.0064
s.dist -0.455
p.adjustANOVA 0.026


Top enriched genes
Top 20 genes
GeneID Gene Rank
ST3GAL2 -8689
MUC3A -7726
MUC1 -7708
ST3GAL1 -7158
ST3GAL4 -6900
ST6GAL1 -5790
ST6GALNAC2 -4631
ST3GAL3 -2898
MUC12 -2818
ST6GALNAC4 1419
MUC20 2839
ST6GALNAC3 6672

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ST3GAL2 -8689
MUC3A -7726
MUC1 -7708
ST3GAL1 -7158
ST3GAL4 -6900
ST6GAL1 -5790
ST6GALNAC2 -4631
ST3GAL3 -2898
MUC12 -2818
ST6GALNAC4 1419
MUC20 2839
ST6GALNAC3 6672


AKT phosphorylates targets in the nucleus
set AKT phosphorylates targets in the nucleus
setSize 10
pANOVA 0.0135
s.dist -0.451
p.adjustANOVA 0.0473


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXO6 -7519
FOXO1 -6611
FOXO3 -5828
CREB1 -5742
FOXO4 -4157
AKT1 -4155
NR4A1 -3373
AKT3 -3284
RPS6KB2 386
AKT2 4478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXO6 -7519
FOXO1 -6611
FOXO3 -5828
CREB1 -5742
FOXO4 -4157
AKT1 -4155
NR4A1 -3373
AKT3 -3284
RPS6KB2 386
AKT2 4478


Attachment and Entry_9694614
set Attachment and Entry_9694614
setSize 16
pANOVA 0.00182
s.dist -0.45
p.adjustANOVA 0.0112


Top enriched genes
Top 20 genes
GeneID Gene Rank
SDC3 -8820
SDC4 -8753
TMPRSS2 -8177
NRP1 -7901
SDC2 -7276
GPC1 -6669
CTSL -6560
GPC6 -6258
FURIN -5673
AGRN -4723
GPC2 -3530
HSPG2 -2248
GPC5 -807
GPC4 6047
SDC1 6099
VCP 8081

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SDC3 -8820
SDC4 -8753
TMPRSS2 -8177
NRP1 -7901
SDC2 -7276
GPC1 -6669
CTSL -6560
GPC6 -6258
FURIN -5673
AGRN -4723
GPC2 -3530
HSPG2 -2248
GPC5 -807
GPC4 6047
SDC1 6099
VCP 8081


Citric acid cycle (TCA cycle)
set Citric acid cycle (TCA cycle)
setSize 33
pANOVA 7.88e-06
s.dist 0.449
p.adjustANOVA 0.000182


Top enriched genes
Top 20 genes
GeneID Gene Rank
SDHA 10579
TRAP1 10515
NFS1 10456
IDH3B 10322
NNT 10177
MDH2 9598
ACAT1 9533
SUCLG2 9388
OGDH 8993
SDHD 8673
DLD 8658
SUCLG1 8495
ISCU 7552
SDHB 7191
DLST 7176
ACO2 7172
SDHAF3 6752
CS 6736
FH 5974
FXN 5500

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SDHA 10579
TRAP1 10515
NFS1 10456
IDH3B 10322
NNT 10177
MDH2 9598
ACAT1 9533
SUCLG2 9388
OGDH 8993
SDHD 8673
DLD 8658
SUCLG1 8495
ISCU 7552
SDHB 7191
DLST 7176
ACO2 7172
SDHAF3 6752
CS 6736
FH 5974
FXN 5500
CSKMT 4982
SUCLA2 2656
SIRT3 2413
SDHC 2399
IDH3G 1075
IDH3A 1016
SDHAF1 830
SDHAF4 234
ISCA1 -851
SDHAF2 -1497
ISCA2 -2502
LYRM4 -2822
IDH2 -5506


Cellular hexose transport
set Cellular hexose transport
setSize 12
pANOVA 0.00712
s.dist -0.449
p.adjustANOVA 0.0286


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC50A1 -7897
SLC45A3 -7462
SLC2A3 -6827
SLC2A1 -6481
SLC2A4 -5702
SLC2A6 -4539
SLC5A10 -4061
SLC2A12 -3589
SLC2A10 -3535
SLC2A8 -987
MFSD4B -310
SLC2A11 8701

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC50A1 -7897
SLC45A3 -7462
SLC2A3 -6827
SLC2A1 -6481
SLC2A4 -5702
SLC2A6 -4539
SLC5A10 -4061
SLC2A12 -3589
SLC2A10 -3535
SLC2A8 -987
MFSD4B -310
SLC2A11 8701


Signalling to RAS
set Signalling to RAS
setSize 19
pANOVA 0.000745
s.dist -0.447
p.adjustANOVA 0.0056


Top enriched genes
Top 20 genes
GeneID Gene Rank
NRAS -8772
MAPK13 -8164
RALA -8038
KRAS -8023
SHC1 -7899
MAPKAPK2 -7616
RALGDS -7214
NTRK1 -6956
SHC3 -6237
RALB -5846
SHC2 -5687
MAPK11 -1481
MAPK12 -368
MAPK14 420
SOS1 675
HRAS 1323
GRB2 2123
SRC 3763
MAPKAPK3 6761

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS -8772
MAPK13 -8164
RALA -8038
KRAS -8023
SHC1 -7899
MAPKAPK2 -7616
RALGDS -7214
NTRK1 -6956
SHC3 -6237
RALB -5846
SHC2 -5687
MAPK11 -1481
MAPK12 -368
MAPK14 420
SOS1 675
HRAS 1323
GRB2 2123
SRC 3763
MAPKAPK3 6761


Respiratory electron transport
set Respiratory electron transport
setSize 151
pANOVA 3.29e-21
s.dist 0.445
p.adjustANOVA 1.67e-18


Top enriched genes
Top 20 genes
GeneID Gene Rank
SDHA 10579
TRAP1 10515
NDUFA10 10465
NFS1 10456
UQCRC2 10297
SCO1 10271
TMEM186 10152
COX15 10114
GOT1 10083
COX7C 9986
MT-ND3 9827
LETM1 9826
NDUFAF2 9675
MT-ND2 9631
NDUFAF1 9613
LYRM7 9612
MDH2 9598
NDUFV1 9591
NDUFS4 9541
UQCRH 9509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SDHA 10579.0
TRAP1 10515.0
NDUFA10 10465.0
NFS1 10456.0
UQCRC2 10297.0
SCO1 10271.0
TMEM186 10152.0
COX15 10114.0
GOT1 10083.0
COX7C 9986.0
MT-ND3 9827.0
LETM1 9826.0
NDUFAF2 9675.0
MT-ND2 9631.0
NDUFAF1 9613.0
LYRM7 9612.0
MDH2 9598.0
NDUFV1 9591.0
NDUFS4 9541.0
UQCRH 9509.0
NDUFS7 9385.0
UQCC2 9359.0
MT-ND1 9352.0
COX18 9303.0
NDUFS6 9290.0
NDUFS8 9259.0
NDUFB5 9253.0
UQCRB 9199.0
HSPA9 9183.0
NDUFAF6 9110.0
SMIM20 9078.0
NDUFAF5 9077.0
FOXRED1 8987.0
TIMM21 8962.0
UQCC5 8933.0
NDUFA9 8793.0
CYC1 8761.0
SDHD 8673.0
NDUFA2 8620.0
COX7B 8597.0
COX6C 8535.0
ETFDH 8454.0
TMEM126A 8452.0
NDUFB6 8356.0
MT-CO3 8348.0
NDUFV2 8330.0
NDUFAF7 8329.0
UQCRFS1 8248.0
HIGD2A 8236.0
NDUFA8 8234.0
BCS1L 8215.0
COX6B1 8213.0
UQCR10 7995.0
COX11 7983.0
NDUFB3 7976.0
UQCRQ 7901.0
ECSIT 7890.0
MT-ND4 7786.0
NDUFS3 7743.0
TACO1 7561.0
ISCU 7552.0
UQCC1 7537.0
NDUFA3 7412.0
NDUFB9 7384.0
NDUFA1 7285.0
NDUFS5 7230.0
SDHB 7191.0
NDUFS1 6875.0
PET117 6643.0
NDUFA12 6459.0
COX6A1 6449.0
COX8A 6421.0
NDUFA7 6417.0
UQCC6 6416.0
NDUFB7 6314.0
NDUFAB1 6152.0
COX14 6124.0
TMEM126B 6036.0
NDUFAF8 5937.0
MT-ND5 5935.0
UQCR11 5648.0
SURF1 5634.0
SFXN4 5616.0
SLC25A11 5599.0
COQ10B 5577.0
UQCRC1 5553.0
MT-ND6 5504.0
FXN 5500.0
NDUFA6 5460.0
GOT2 5441.0
MT-CO1 5389.0
NDUFB10 5310.0
COX7A2L 4931.0
TIMMDC1 4866.0
NDUFB1 4689.0
NDUFA4 4632.0
NDUFV3 4562.0
NDUFC2 4550.0
NDUFS2 4276.0
NDUFA13 4218.0
COA3 4117.0
COX4I1 4053.0
MT-CYB 3888.0
UQCC3 3690.0
TTC19 3552.0
SLC25A13 3519.0
NDUFA5 3461.0
CMC1 3427.0
RAB5IF 3355.0
NDUFC1 3238.0
NDUFAF3 3047.0
PET100 2891.0
COX20 2829.0
SLC25A22 2605.0
CYCS 2541.0
MDH1 2503.0
COX5A 2457.0
SDHC 2399.0
NDUFAF4 2078.0
NDUFB2 1872.0
ACAD9 1529.0
COQ10A 1197.0
NDUFA11 1084.0
COX16 1060.0
COA1 932.0
MT-CO2 819.0
SLC25A12 816.0
HIGD1A 351.0
PYURF 312.5
OXA1L -353.0
SLC25A18 -666.0
HCCS -1410.0
TMEM223 -1438.0
NDUFB8 -1774.0
TMEM177 -1980.0
COX5B -2120.0
NDUFB11 -2406.0
NUBPL -2499.0
NDUFB4 -2645.0
LYRM4 -2822.0
COX7A2 -2888.0
PNKD -2958.0
LYRM2 -3500.0
ETFA -4289.0
SCO2 -4445.0
COX17 -4543.0
COX19 -4744.0
COX6B2 -4851.0
COA5 -5873.0
HSCB -6005.0
ETFB -8853.0


N-glycan antennae elongation in the medial/trans-Golgi
set N-glycan antennae elongation in the medial/trans-Golgi
setSize 20
pANOVA 0.00063
s.dist -0.441
p.adjustANOVA 0.00508


Top enriched genes
Top 20 genes
GeneID Gene Rank
MGAT3 -8911
CHST8 -8614
FUCA1 -8589
ST8SIA2 -8445
B4GALT5 -8379
MGAT5 -7479
B4GALT3 -7196
ST3GAL4 -6900
MAN2A2 -6692
ST6GAL1 -5790
MGAT4B -5484
MGAT2 -4753
MGAT4A -4501
CHST10 -4252
B4GALT4 -1769
B4GALT1 712
MAN2A1 3430
FUT8 6917
B4GALT6 8026
B4GALT2 8948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MGAT3 -8911
CHST8 -8614
FUCA1 -8589
ST8SIA2 -8445
B4GALT5 -8379
MGAT5 -7479
B4GALT3 -7196
ST3GAL4 -6900
MAN2A2 -6692
ST6GAL1 -5790
MGAT4B -5484
MGAT2 -4753
MGAT4A -4501
CHST10 -4252
B4GALT4 -1769
B4GALT1 712
MAN2A1 3430
FUT8 6917
B4GALT6 8026
B4GALT2 8948


Glyoxylate metabolism and glycine degradation
set Glyoxylate metabolism and glycine degradation
setSize 11
pANOVA 0.0114
s.dist 0.441
p.adjustANOVA 0.0411


Top enriched genes
Top 20 genes
GeneID Gene Rank
GRHPR 10374
ALDH4A1 9965
OGDH 8993
DLD 8658
GCSH 7833
DLST 7176
AMT 6994
GOT2 5441
PXMP2 384
GLDC -4505
DDO -4904

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRHPR 10374
ALDH4A1 9965
OGDH 8993
DLD 8658
GCSH 7833
DLST 7176
AMT 6994
GOT2 5441
PXMP2 384
GLDC -4505
DDO -4904


SARS-CoV-1 modulates host translation machinery
set SARS-CoV-1 modulates host translation machinery
setSize 35
pANOVA 6.7e-06
s.dist -0.44
p.adjustANOVA 0.000157


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS27 -8634
RPS27A -7861
RPS18 -7840
EEF1A1 -7245
RPS7 -7202
RPS3A -7031
RPS11 -6968
RPS29 -6411
RPS9 -6212
RPS12 -5559
RPS16 -5431
RPS24 -5421
RPS15 -5306
RPS19 -5096
RPS25 -5017
RPS17 -4980
RPS27L -4647
RPS8 -4415
RPS10 -4341
RPS5 -4304

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27 -8634
RPS27A -7861
RPS18 -7840
EEF1A1 -7245
RPS7 -7202
RPS3A -7031
RPS11 -6968
RPS29 -6411
RPS9 -6212
RPS12 -5559
RPS16 -5431
RPS24 -5421
RPS15 -5306
RPS19 -5096
RPS25 -5017
RPS17 -4980
RPS27L -4647
RPS8 -4415
RPS10 -4341
RPS5 -4304
RPS28 -4273
RPS23 -4209
RPS13 -4063
RPS4X -3996
RPS3 -3209
RPS6 -2358
RPS2 -1485
RPS21 382
FAU 610
HNRNPA1 996
RPSA 2007
RPS14 3607
RPS15A 3729
RPS20 4247
RPS26 6637


rRNA processing in the mitochondrion
set rRNA processing in the mitochondrion
setSize 27
pANOVA 7.94e-05
s.dist 0.439
p.adjustANOVA 0.00104


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTERF4 10248
MT-ATP8 10139
MT-ATP6 9901
MT-ND3 9827
MT-ND2 9631
MT-ND1 9352
ELAC2 8743
MT-ND4L 8578
MT-CO3 8348
MT-TL2 8128
MT-ND4 7786
MRM1 6300
MT-RNR1 6027
MT-ND5 5935
MRM3 5844
MT-CO1 5389
MT-CYB 3888
PRORP 3868
MT-RNR2 2991
TFB1M 2872

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTERF4 10248
MT-ATP8 10139
MT-ATP6 9901
MT-ND3 9827
MT-ND2 9631
MT-ND1 9352
ELAC2 8743
MT-ND4L 8578
MT-CO3 8348
MT-TL2 8128
MT-ND4 7786
MRM1 6300
MT-RNR1 6027
MT-ND5 5935
MRM3 5844
MT-CO1 5389
MT-CYB 3888
PRORP 3868
MT-RNR2 2991
TFB1M 2872
TRMT10C 1097
MRM2 915
MT-CO2 819
MT-TL1 141
HSD17B10 -107
MT-TV -3767
NSUN4 -5051


Lysine catabolism
set Lysine catabolism
setSize 12
pANOVA 0.00916
s.dist 0.434
p.adjustANOVA 0.0345


Top enriched genes
Top 20 genes
GeneID Gene Rank
GCDH 10142
HYKK 9966
AASS 9641
DLD 8658
ALDH7A1 8004
DHTKD1 7939
DLST 7176
AADAT 4414
SLC25A21 3024
PHYKPL -1055
PIPOX -1469
CRYM -5637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GCDH 10142
HYKK 9966
AASS 9641
DLD 8658
ALDH7A1 8004
DHTKD1 7939
DLST 7176
AADAT 4414
SLC25A21 3024
PHYKPL -1055
PIPOX -1469
CRYM -5637


NOTCH2 intracellular domain regulates transcription
set NOTCH2 intracellular domain regulates transcription
setSize 10
pANOVA 0.0181
s.dist -0.432
p.adjustANOVA 0.0584


Top enriched genes
Top 20 genes
GeneID Gene Rank
HES1 -8572
MAMLD1 -6840
MAML3 -5747
CREB1 -5742
RBPJ -5393
MAML2 -4658
NOTCH2 -3785
EP300 -1942
FCER2 1691
MAML1 7076

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HES1 -8572
MAMLD1 -6840
MAML3 -5747
CREB1 -5742
RBPJ -5393
MAML2 -4658
NOTCH2 -3785
EP300 -1942
FCER2 1691
MAML1 7076


Regulation of localization of FOXO transcription factors
set Regulation of localization of FOXO transcription factors
setSize 12
pANOVA 0.01
s.dist -0.429
p.adjustANOVA 0.037


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXO6 -7519
SFN -7093
FOXO1 -6611
FOXO3 -5828
FOXO4 -4157
AKT1 -4155
AKT3 -3284
YWHAG -3104
YWHAQ -2976
YWHAZ -2443
YWHAB 2273
AKT2 4478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXO6 -7519
SFN -7093
FOXO1 -6611
FOXO3 -5828
FOXO4 -4157
AKT1 -4155
AKT3 -3284
YWHAG -3104
YWHAQ -2976
YWHAZ -2443
YWHAB 2273
AKT2 4478


WNT5A-dependent internalization of FZD4
set WNT5A-dependent internalization of FZD4
setSize 15
pANOVA 0.00436
s.dist 0.425
p.adjustANOVA 0.0201


Top enriched genes
Top 20 genes
GeneID Gene Rank
PRKCA 10398
CLTC 9701
AP2B1 9651
DVL2 8854
AP2A1 7787
CLTB 7114
PRKCG 6968
CLTA 5952
ARRB2 5404
FZD4 4987
AP2A2 4459
AP2S1 4191
AP2M1 4108
WNT5A -6040
PRKCB -8898

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKCA 10398
CLTC 9701
AP2B1 9651
DVL2 8854
AP2A1 7787
CLTB 7114
PRKCG 6968
CLTA 5952
ARRB2 5404
FZD4 4987
AP2A2 4459
AP2S1 4191
AP2M1 4108
WNT5A -6040
PRKCB -8898


p38MAPK events
set p38MAPK events
setSize 13
pANOVA 0.00796
s.dist -0.425
p.adjustANOVA 0.031


Top enriched genes
Top 20 genes
GeneID Gene Rank
NRAS -8772
MAPK13 -8164
RALA -8038
KRAS -8023
MAPKAPK2 -7616
RALGDS -7214
RALB -5846
MAPK11 -1481
MAPK12 -368
MAPK14 420
HRAS 1323
SRC 3763
MAPKAPK3 6761

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS -8772
MAPK13 -8164
RALA -8038
KRAS -8023
MAPKAPK2 -7616
RALGDS -7214
RALB -5846
MAPK11 -1481
MAPK12 -368
MAPK14 420
HRAS 1323
SRC 3763
MAPKAPK3 6761


Diseases of DNA repair
set Diseases of DNA repair
setSize 51
pANOVA 1.5e-07
s.dist 0.425
p.adjustANOVA 6.03e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD50 10438
RAD17 9443
RAD9B 9373
ATR 9330
RAD9A 9318
MUTYH 9193
RBBP8 9058
RPA2 8814
KAT5 8661
NBN 8629
RAD51C 8243
RPA1 8034
PMS2 7763
NTHL1 7389
PALB2 7150
WRN 6902
MSH3 6480
SEM1 6444
BRCA2 6309
ATRIP 6216

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD50 10438
RAD17 9443
RAD9B 9373
ATR 9330
RAD9A 9318
MUTYH 9193
RBBP8 9058
RPA2 8814
KAT5 8661
NBN 8629
RAD51C 8243
RPA1 8034
PMS2 7763
NTHL1 7389
PALB2 7150
WRN 6902
MSH3 6480
SEM1 6444
BRCA2 6309
ATRIP 6216
OGG1 6063
MRE11 5964
TOP3A 5753
RAD51B 5679
BRCA1 5567
RFC4 5546
MLH1 5464
NEIL3 5265
DNA2 5106
XRCC2 5082
RAD1 5035
BRIP1 4620
RAD51AP1 4072
RAD51D 3783
RHNO1 3740
MSH6 3723
MSH2 3653
RPA3 3163
RFC2 3023
BARD1 2964
RFC3 2918
RFC5 2901
BLM 2630
RMI1 2439
EXO1 2319
NEIL1 120
ATM -774
TOPBP1 -1064
RMI2 -3532
RAD51 -3656
HUS1 -7432


SHC-mediated cascade:FGFR1
set SHC-mediated cascade:FGFR1
setSize 13
pANOVA 0.00816
s.dist -0.424
p.adjustANOVA 0.0314


Top enriched genes
Top 20 genes
GeneID Gene Rank
NRAS -8772
FGF9 -8523
KRAS -8023
KL -7917
SHC1 -7899
FGF1 -7849
FGFR1 -7665
FGF10 -4566
SOS1 675
HRAS 1323
GRB2 2123
FGF2 3713
FGF5 10300

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS -8772
FGF9 -8523
KRAS -8023
KL -7917
SHC1 -7899
FGF1 -7849
FGFR1 -7665
FGF10 -4566
SOS1 675
HRAS 1323
GRB2 2123
FGF2 3713
FGF5 10300


MET activates RAP1 and RAC1
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.0215
s.dist -0.42
p.adjustANOVA 0.0671


Top enriched genes
Top 20 genes
GeneID Gene Rank
CRKL -8392
RAP1A -8386
RAC1 -8329
DOCK7 -4971
CRK -4305
RAP1B -3868
GAB1 -3157
RAPGEF1 747
GRB2 2123
MET 5783

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL -8392
RAP1A -8386
RAC1 -8329
DOCK7 -4971
CRK -4305
RAP1B -3868
GAB1 -3157
RAPGEF1 747
GRB2 2123
MET 5783


CLEC7A (Dectin-1) induces NFAT activation
set CLEC7A (Dectin-1) induces NFAT activation
setSize 11
pANOVA 0.0167
s.dist -0.417
p.adjustANOVA 0.0553


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP3CA -7308
ITPR3 -7128
PPP3R1 -6897
CALM1 -6328
AHCYL1 -4764
NFATC2 -4307
PPP3CB -2755
NFATC1 -1928
ITPR2 -304
ITPR1 761
NFATC3 5260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP3CA -7308
ITPR3 -7128
PPP3R1 -6897
CALM1 -6328
AHCYL1 -4764
NFATC2 -4307
PPP3CB -2755
NFATC1 -1928
ITPR2 -304
ITPR1 761
NFATC3 5260


Signalling to ERKs
set Signalling to ERKs
setSize 32
pANOVA 4.6e-05
s.dist -0.416
p.adjustANOVA 0.000661


Top enriched genes
Top 20 genes
GeneID Gene Rank
NRAS -8772
MAP2K1 -8463
RIT1 -8413
CRKL -8392
RAP1A -8386
MAPK13 -8164
RALA -8038
KRAS -8023
SHC1 -7899
MAPKAPK2 -7616
RALGDS -7214
NTRK1 -6956
SHC3 -6237
RALB -5846
SHC2 -5687
MAPK1 -4310
CRK -4305
KIDINS220 -3199
MAPK11 -1481
MAPK3 -1127

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS -8772
MAP2K1 -8463
RIT1 -8413
CRKL -8392
RAP1A -8386
MAPK13 -8164
RALA -8038
KRAS -8023
SHC1 -7899
MAPKAPK2 -7616
RALGDS -7214
NTRK1 -6956
SHC3 -6237
RALB -5846
SHC2 -5687
MAPK1 -4310
CRK -4305
KIDINS220 -3199
MAPK11 -1481
MAPK3 -1127
MAPK12 -368
BRAF -190
MAPK14 420
FRS2 637
SOS1 675
RAPGEF1 747
HRAS 1323
GRB2 2123
YWHAB 2273
SRC 3763
MAPKAPK3 6761
MAP2K2 6791


Chemokine receptors bind chemokines
set Chemokine receptors bind chemokines
setSize 15
pANOVA 0.0053
s.dist -0.416
p.adjustANOVA 0.0227


Top enriched genes
Top 20 genes
GeneID Gene Rank
CX3CL1 -8866
CXCL16 -8707
CXCL11 -8631
ACKR3 -8548
CXCR4 -8050
CXCL10 -6575
CXCL1 -5018
CXCL3 -2784
CCR10 -2638
CCL28 -1285
CXCL8 -574
CCL2 -461
CXCL2 667
ACKR2 2473
CXCL12 10453

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CX3CL1 -8866
CXCL16 -8707
CXCL11 -8631
ACKR3 -8548
CXCR4 -8050
CXCL10 -6575
CXCL1 -5018
CXCL3 -2784
CCR10 -2638
CCL28 -1285
CXCL8 -574
CCL2 -461
CXCL2 667
ACKR2 2473
CXCL12 10453


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.12.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] ggplot2_3.5.1               gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              kableExtra_1.4.0           
##  [9] eulerr_7.0.2                mitch_1.19.2               
## [11] MASS_7.3-61                 gplots_3.2.0               
## [13] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [15] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [17] matrixStats_1.4.1           GenomicRanges_1.56.1       
## [19] GenomeInfoDb_1.40.1         IRanges_2.38.1             
## [21] S4Vectors_0.42.1            BiocGenerics_0.50.0        
## [23] reshape2_1.4.4              dplyr_1.1.4                
## [25] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] tidyselect_1.2.1        viridisLite_0.4.2       bitops_1.0-9           
##  [4] fastmap_1.2.0           promises_1.3.2          digest_0.6.37          
##  [7] mime_0.12               lifecycle_1.0.4         magrittr_2.0.3         
## [10] compiler_4.4.2          sass_0.4.9              rlang_1.1.4            
## [13] tools_4.4.2             yaml_2.3.10             knitr_1.49             
## [16] S4Arrays_1.4.1          htmlwidgets_1.6.4       DelayedArray_0.30.1    
## [19] xml2_1.3.6              plyr_1.8.9              RColorBrewer_1.1-3     
## [22] abind_1.4-8             BiocParallel_1.38.0     KernSmooth_2.23-24     
## [25] withr_3.0.2             purrr_1.0.2             grid_4.4.2             
## [28] caTools_1.18.3          xtable_1.8-4            colorspace_2.1-1       
## [31] scales_1.3.0            cli_3.6.3               rmarkdown_2.29         
## [34] crayon_1.5.3            generics_0.1.3          rstudioapi_0.17.1      
## [37] httr_1.4.7              cachem_1.1.0            stringr_1.5.1          
## [40] zlibbioc_1.50.0         parallel_4.4.2          XVector_0.44.0         
## [43] vctrs_0.6.5             Matrix_1.7-1            jsonlite_1.8.9         
## [46] systemfonts_1.1.0       locfit_1.5-9.10         jquerylib_0.1.4        
## [49] tidyr_1.3.1             glue_1.8.0              ggstats_0.7.0          
## [52] codetools_0.2-20        stringi_1.8.4           gtable_0.3.6           
## [55] later_1.4.1             UCSC.utils_1.0.0        munsell_0.5.1          
## [58] pillar_1.10.0           htmltools_0.5.8.1       GenomeInfoDbData_1.2.12
## [61] R6_2.5.1                shiny_1.10.0            evaluate_1.0.1         
## [64] lattice_0.22-6          bslib_0.8.0             httpuv_1.6.15          
## [67] Rcpp_1.0.13-1           svglite_2.1.3           gridExtra_2.3          
## [70] SparseArray_1.4.8       xfun_0.49               pkgconfig_2.0.3

END of report