Mitch Report

date generated: 2020-10-08

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           diabetes       mitoG
## A1CF    -6.9932602  1.51849480
## A3GALT2 -0.4812996  0.04044782
## A4GALT   3.2528398 -0.66706468
## A4GNT    1.2215327  0.29060394
## AAAS     1.7926927 -0.52232889
## AACS    -2.0466443 -0.59825125

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genes_in_profile	15635
duplicated_genes_present	0
num_profile_genes_in_sets	2931
num_profile_genes_not_in_sets	12704
profile_pearson_correl	-0.26909
profile_spearman_correl	-0.21206

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: genesetsofinterest.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	47
num_genesets_excluded	10
num_genesets_included	37

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 18

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 37 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diabetes	s.mitoG	p.diabetes	p.mitoG
BAELDE DIABETIC NEPHROPATHY DN	418	8.12e-24	3.00e-22	0.2980	-0.04700	0.2940	1.00e-01	7.25e-25
GSE9006 TYPE 1 VS TYPE 2 DIABETES PBMC AT DX DN	179	4.05e-19	7.48e-18	0.4310	-0.21200	0.3750	1.04e-06	4.89e-18
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC AT DX UP	186	8.32e-12	1.03e-10	0.3070	-0.04840	0.3040	2.56e-01	9.83e-13
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 1MONTH POST DX UP	192	1.16e-11	1.07e-10	0.3130	-0.10600	0.2940	1.11e-02	2.31e-12
The citric acid (TCA) cycle and respiratory electron transport	168	1.10e-08	8.16e-08	0.2410	0.16200	0.1780	2.88e-04	7.32e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	120	5.69e-08	3.51e-07	0.2740	0.23800	0.1370	6.91e-06	9.66e-03
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 4MONTH POST DX UP	193	1.45e-07	7.66e-07	0.2310	-0.00752	0.2310	8.57e-01	3.40e-08
GSE9006 HEALTHY VS TYPE 2 DIABETES PBMC AT DX DN	170	4.30e-07	1.99e-06	0.2590	-0.11900	0.2300	7.42e-03	2.38e-07
Activation of NF-kappaB in B cells	66	8.09e-07	3.33e-06	0.4140	-0.31900	0.2650	7.64e-06	2.02e-04
Respiratory electron transport	99	2.09e-06	7.73e-06	0.2660	0.22100	0.1480	1.44e-04	1.12e-02
Gluconeogenesis	30	4.13e-06	1.39e-05	0.4930	0.48200	0.1010	4.87e-06	3.37e-01
BAELDE DIABETIC NEPHROPATHY UP	78	7.25e-04	2.24e-03	0.2260	0.20500	0.0948	1.75e-03	1.48e-01
GSE9006 TYPE 1 VS TYPE 2 DIABETES PBMC AT DX UP	195	1.03e-03	2.94e-03	0.1580	0.03210	-0.1540	4.40e-01	2.08e-04
GSE9006 TYPE 1 DIABETES AT DX VS 4MONTH POST DX PBMC DN	148	3.93e-03	1.04e-02	0.1410	0.08650	0.1120	6.96e-02	1.92e-02
GSE40225 WT VS RIP B7X DIABETIC MOUSE PANCREATIC CD8 TCELL DN	179	5.15e-03	1.27e-02	0.1530	-0.08420	0.1280	5.25e-02	3.12e-03
HP TYPE I DIABETES MELLITUS	38	1.16e-02	2.69e-02	0.2520	0.11700	0.2240	2.12e-01	1.70e-02
GSE9006 TYPE 1 DIABETES AT DX VS 1MONTH POST DX PBMC UP	187	1.50e-02	3.26e-02	0.1320	-0.05630	0.1190	1.85e-01	5.11e-03
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC AT DX DN	162	1.69e-02	3.48e-02	0.1220	0.02510	0.1200	5.82e-01	8.75e-03
GSE9006 1MONTH VS 4MONTH POST TYPE 1 DIABETES DX PBMC UP	167	2.88e-02	5.61e-02	0.1170	-0.00264	0.1170	9.53e-01	8.93e-03
HP NEPHROPATHY	90	4.60e-02	8.52e-02	0.1350	0.08870	0.1010	1.46e-01	9.74e-02
GSE9006 TYPE 1 DIABETES AT DX VS 4MONTH POST DX PBMC UP	182	4.87e-02	8.58e-02	0.1050	-0.00885	0.1050	8.37e-01	1.48e-02
HP MATERNAL DIABETES	21	5.43e-02	9.13e-02	0.2910	-0.03160	-0.2890	8.02e-01	2.18e-02
KEGG TYPE I DIABETES MELLITUS	25	6.90e-02	1.09e-01	0.2560	-0.25500	-0.0245	2.74e-02	8.32e-01
GSE9006 TYPE 1 DIABETES AT DX VS 1MONTH POST DX PBMC DN	165	7.05e-02	1.09e-01	0.0925	0.05840	0.0718	1.96e-01	1.12e-01
HP TYPE II DIABETES MELLITUS	139	7.92e-02	1.17e-01	0.1200	0.10400	-0.0590	3.42e-02	2.31e-01
GSE40225 WT VS RIP B7X DIABETIC MOUSE PANCREATIC CD8 TCELL UP	169	1.03e-01	1.46e-01	0.1040	-0.08490	0.0603	5.73e-02	1.77e-01
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 1MONTH POST DX DN	153	2.17e-01	2.97e-01	0.0896	0.05170	-0.0732	2.71e-01	1.19e-01
HP NEONATAL INSULIN DEPENDENT DIABETES MELLITUS	10	3.38e-01	4.47e-01	0.2390	0.16600	0.1720	3.64e-01	3.47e-01
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 4MONTH POST DX DN	160	4.25e-01	5.37e-01	0.0535	-0.03110	-0.0435	4.97e-01	3.43e-01
KEGG MATURITY ONSET DIABETES OF THE YOUNG	13	4.35e-01	5.37e-01	0.2200	0.08870	-0.2010	5.80e-01	2.09e-01
WP TYPE II DIABETES MELLITUS	20	6.20e-01	7.40e-01	0.1220	-0.00833	-0.1210	9.49e-01	3.47e-01
GSE9006 HEALTHY VS TYPE 2 DIABETES PBMC AT DX UP	189	6.48e-01	7.49e-01	0.0431	0.02540	-0.0348	5.48e-01	4.10e-01
KEGG TYPE II DIABETES MELLITUS	41	7.21e-01	7.85e-01	0.0692	0.01080	0.0684	9.05e-01	4.49e-01
GSE9006 1MONTH VS 4MONTH POST TYPE 1 DIABETES DX PBMC DN	152	7.21e-01	7.85e-01	0.0350	0.03300	0.0114	4.83e-01	8.08e-01
HP INSULIN RESISTANT DIABETES MELLITUS	26	7.61e-01	8.04e-01	0.0749	0.04100	0.0627	7.17e-01	5.80e-01
HP DIABETES INSIPIDUS	33	8.20e-01	8.30e-01	0.0576	0.05290	0.0229	5.99e-01	8.20e-01
TNFR1-induced NFkappaB signaling pathway	26	8.30e-01	8.30e-01	0.0633	0.02260	0.0591	8.42e-01	6.02e-01

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diabetes	s.mitoG	p.diabetes	p.mitoG
BAELDE DIABETIC NEPHROPATHY DN	418	8.12e-24	3.00e-22	0.2980	-0.04700	0.2940	1.00e-01	7.25e-25
GSE9006 TYPE 1 VS TYPE 2 DIABETES PBMC AT DX DN	179	4.05e-19	7.48e-18	0.4310	-0.21200	0.3750	1.04e-06	4.89e-18
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC AT DX UP	186	8.32e-12	1.03e-10	0.3070	-0.04840	0.3040	2.56e-01	9.83e-13
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 1MONTH POST DX UP	192	1.16e-11	1.07e-10	0.3130	-0.10600	0.2940	1.11e-02	2.31e-12
The citric acid (TCA) cycle and respiratory electron transport	168	1.10e-08	8.16e-08	0.2410	0.16200	0.1780	2.88e-04	7.32e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	120	5.69e-08	3.51e-07	0.2740	0.23800	0.1370	6.91e-06	9.66e-03
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 4MONTH POST DX UP	193	1.45e-07	7.66e-07	0.2310	-0.00752	0.2310	8.57e-01	3.40e-08
GSE9006 HEALTHY VS TYPE 2 DIABETES PBMC AT DX DN	170	4.30e-07	1.99e-06	0.2590	-0.11900	0.2300	7.42e-03	2.38e-07
Activation of NF-kappaB in B cells	66	8.09e-07	3.33e-06	0.4140	-0.31900	0.2650	7.64e-06	2.02e-04
Respiratory electron transport	99	2.09e-06	7.73e-06	0.2660	0.22100	0.1480	1.44e-04	1.12e-02
Gluconeogenesis	30	4.13e-06	1.39e-05	0.4930	0.48200	0.1010	4.87e-06	3.37e-01
BAELDE DIABETIC NEPHROPATHY UP	78	7.25e-04	2.24e-03	0.2260	0.20500	0.0948	1.75e-03	1.48e-01
GSE9006 TYPE 1 VS TYPE 2 DIABETES PBMC AT DX UP	195	1.03e-03	2.94e-03	0.1580	0.03210	-0.1540	4.40e-01	2.08e-04
GSE9006 TYPE 1 DIABETES AT DX VS 4MONTH POST DX PBMC DN	148	3.93e-03	1.04e-02	0.1410	0.08650	0.1120	6.96e-02	1.92e-02
GSE40225 WT VS RIP B7X DIABETIC MOUSE PANCREATIC CD8 TCELL DN	179	5.15e-03	1.27e-02	0.1530	-0.08420	0.1280	5.25e-02	3.12e-03
HP TYPE I DIABETES MELLITUS	38	1.16e-02	2.69e-02	0.2520	0.11700	0.2240	2.12e-01	1.70e-02
GSE9006 TYPE 1 DIABETES AT DX VS 1MONTH POST DX PBMC UP	187	1.50e-02	3.26e-02	0.1320	-0.05630	0.1190	1.85e-01	5.11e-03
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC AT DX DN	162	1.69e-02	3.48e-02	0.1220	0.02510	0.1200	5.82e-01	8.75e-03
GSE9006 1MONTH VS 4MONTH POST TYPE 1 DIABETES DX PBMC UP	167	2.88e-02	5.61e-02	0.1170	-0.00264	0.1170	9.53e-01	8.93e-03
HP NEPHROPATHY	90	4.60e-02	8.52e-02	0.1350	0.08870	0.1010	1.46e-01	9.74e-02
GSE9006 TYPE 1 DIABETES AT DX VS 4MONTH POST DX PBMC UP	182	4.87e-02	8.58e-02	0.1050	-0.00885	0.1050	8.37e-01	1.48e-02
HP MATERNAL DIABETES	21	5.43e-02	9.13e-02	0.2910	-0.03160	-0.2890	8.02e-01	2.18e-02
KEGG TYPE I DIABETES MELLITUS	25	6.90e-02	1.09e-01	0.2560	-0.25500	-0.0245	2.74e-02	8.32e-01
GSE9006 TYPE 1 DIABETES AT DX VS 1MONTH POST DX PBMC DN	165	7.05e-02	1.09e-01	0.0925	0.05840	0.0718	1.96e-01	1.12e-01
HP TYPE II DIABETES MELLITUS	139	7.92e-02	1.17e-01	0.1200	0.10400	-0.0590	3.42e-02	2.31e-01
GSE40225 WT VS RIP B7X DIABETIC MOUSE PANCREATIC CD8 TCELL UP	169	1.03e-01	1.46e-01	0.1040	-0.08490	0.0603	5.73e-02	1.77e-01
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 1MONTH POST DX DN	153	2.17e-01	2.97e-01	0.0896	0.05170	-0.0732	2.71e-01	1.19e-01
HP NEONATAL INSULIN DEPENDENT DIABETES MELLITUS	10	3.38e-01	4.47e-01	0.2390	0.16600	0.1720	3.64e-01	3.47e-01
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 4MONTH POST DX DN	160	4.25e-01	5.37e-01	0.0535	-0.03110	-0.0435	4.97e-01	3.43e-01
KEGG MATURITY ONSET DIABETES OF THE YOUNG	13	4.35e-01	5.37e-01	0.2200	0.08870	-0.2010	5.80e-01	2.09e-01
WP TYPE II DIABETES MELLITUS	20	6.20e-01	7.40e-01	0.1220	-0.00833	-0.1210	9.49e-01	3.47e-01
GSE9006 HEALTHY VS TYPE 2 DIABETES PBMC AT DX UP	189	6.48e-01	7.49e-01	0.0431	0.02540	-0.0348	5.48e-01	4.10e-01
KEGG TYPE II DIABETES MELLITUS	41	7.21e-01	7.85e-01	0.0692	0.01080	0.0684	9.05e-01	4.49e-01
GSE9006 1MONTH VS 4MONTH POST TYPE 1 DIABETES DX PBMC DN	152	7.21e-01	7.85e-01	0.0350	0.03300	0.0114	4.83e-01	8.08e-01
HP INSULIN RESISTANT DIABETES MELLITUS	26	7.61e-01	8.04e-01	0.0749	0.04100	0.0627	7.17e-01	5.80e-01
HP DIABETES INSIPIDUS	33	8.20e-01	8.30e-01	0.0576	0.05290	0.0229	5.99e-01	8.20e-01
TNFR1-induced NFkappaB signaling pathway	26	8.30e-01	8.30e-01	0.0633	0.02260	0.0591	8.42e-01	6.02e-01

Detailed Gene set reports

BAELDE_DIABETIC_NEPHROPATHY_DN

BAELDE_DIABETIC_NEPHROPATHY_DN
metric	value
setSize	418
pMANOVA	8.12e-24
p.adjustMANOVA	3e-22
s.dist	0.298
s.diabetes	-0.047
s.mitoG	0.294
p.diabetes	0.1
p.mitoG	7.25e-25

Top 20 genes
Gene	diabetes	mitoG
HSP90AA1	-7286	8742
CAMSAP2	-7075	8823
HNRNPC	-7051	8787
HNRNPA3	-6985	8827
HSP90B1	-7279	8368
CANX	-6936	8532
NEK7	-6954	8505
SKP1	-6803	8394
PDIA3	-7283	7821
HSPA5	-7309	7589
UGP2	-6121	8636
RDX	-6580	7989
RAD23B	-6778	7740
DNAJB9	-6535	8004
SDC2	-6850	7623
RNF11	-7128	7320
RAB1A	-6571	7889
HPGD	-6103	8382
ARID5B	-7136	7137
NAB1	-5905	8617

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AASDHPPT	1006.0	-284.0
AASS	-5588.0	6592.0
ABI1	-4630.0	8305.0
ACADM	-6050.0	5877.0
ACBD3	-2828.0	5524.0
ACSL3	4910.0	5105.0
ACTG1	-1502.0	1482.0
ACTR3	-3716.0	8206.0
ADD3	-5576.0	3921.0
ADM	7469.0	6606.0
ADORA1	6853.0	1954.0
AGRN	-2966.0	-6131.0
AIF1	-4099.0	2383.0
AKAP10	-5977.0	-1227.0
AKAP11	-1764.0	6756.0
ALDH3B1	7287.0	4258.0
ANXA1	7055.0	8221.0
AP3B1	3159.0	1998.0
APOD	7042.0	5748.0
APOL1	-5660.5	2701.5
AQP3	6699.0	3015.0
ARHGAP19	3282.5	2517.5
ARHGAP5	-4817.0	8593.0
ARHGEF18	5858.5	-119.5
ARID5B	-7136.0	7137.0
ARL1	-4284.0	8747.0
ARMCX2	-127.0	6066.0
ATP13A3	-6713.0	1547.0
ATP2A2	-7302.0	1164.0
ATP6AP2	596.0	3605.0
ATP7A	-3222.0	7692.0
ATP9A	2751.0	-5901.0
ATXN1	5463.0	-5164.0
ATXN10	5458.0	7404.0
AXL	2690.0	8077.0
B4GAT1	7224.0	-6185.0
BCAM	7750.0	2432.0
BCAR3	5770.0	4210.0
BEX4	-5280.0	-299.0
BIRC2	-4230.0	3665.0
BIRC3	6091.0	6158.0
BMP2	4300.0	7938.0
BMP7	8109.0	-1080.0
BST2	-460.0	-4229.0
C1R	1107.0	6557.0
C1S	644.0	7556.0
CACNB2	5838.0	-5134.0
CALD1	-3883.0	8801.0
CALM2	4763.0	8625.0
CALU	-3535.0	8715.0
CAMSAP2	-7075.0	8823.0
CAND2	6037.0	-3746.0
CANX	-6936.0	8532.0
CAPN2	5357.0	7435.0
CASP1	-1051.0	1558.0
CAST	3920.0	8492.0
CBLB	-3155.0	5963.0
CCDC6	-7278.0	-704.0
CCN1	-4142.0	4431.0
CCN2	4056.0	8456.0
CD164	4917.0	4249.0
CD200	5072.0	7059.0
CD2AP	1296.0	8225.0
CD47	-1991.0	7809.0
CD55	-6863.0	6749.0
CDC14A	-366.0	4455.0
CDC42EP3	-2134.0	8017.0
CDKN1C	8161.0	5620.0
CDS1	7794.0	278.0
CDV3	6007.0	6969.0
CEBPD	3288.0	6984.0
CERS6	-1584.0	1516.0
CFLAR	-4054.0	2224.0
CHD3	-7230.0	-2465.0
CHI3L1	3964.0	708.0
CHST2	2012.0	6764.0
CITED2	-1285.0	2778.0
CLEC16A	-3534.0	4164.0
CLIC5	1754.0	4129.0
CLIP3	6391.0	383.0
COL3A1	-2073.0	3836.0
COL4A3	-7009.0	2651.0
COL4A4	-7080.0	-2678.0
COL4A6	-3205.0	1099.0
COLQ	5431.0	-3281.0
CORO2B	4667.0	6811.0
CR1	-4680.0	4418.0
CREB3L2	-2683.0	-4241.0
CRIM1	425.0	5416.0
CTBP1	2741.0	-5332.0
CTDSPL	-6769.0	-3198.0
CTNNA1	2129.0	7795.0
CTNNBIP1	2783.0	-1863.0
CXADR	-7100.0	3254.0
CYP1B1	7373.0	8462.0
CYP51A1	39.0	-254.0
DAG1	6646.0	3480.0
DCAF8	32.0	-4825.0
DCTD	-3347.0	491.0
DDN	6361.0	876.0
DDX17	-6389.0	-6574.0
DLG5	7242.0	-2644.0
DNAJA1	-7303.0	6518.0
DNAJB9	-6535.0	8004.0
DNM1L	-4825.0	8774.0
DPP6	2037.0	1202.0
DPYSL3	-516.0	3651.0
DST	1303.0	1938.0
DSTN	3956.0	8525.0
DUSP1	-2905.0	-1666.0
DUSP14	3618.0	-3426.0
DYRK1A	692.0	5205.0
ECM2	4746.0	2978.0
EFR3A	-4691.0	7308.0
EID1	-5024.0	6090.0
EIF3M	-2954.0	7258.0
EIF4A2	-6848.0	-699.0
ELF2	2203.0	5901.0
ENPEP	7508.0	2528.0
EPS15	-5197.0	5904.0
ERBB4	2718.0	2425.0
EXPH5	1020.0	7614.0
F2R	7855.0	8597.0
F3	3208.0	6573.0
F8A1	4778.0	-4244.0
FAM98A	-6507.0	4863.0
FAT1	-697.0	5764.0
FBXO21	8209.0	-5962.0
FERMT2	5215.0	7566.0
FGF1	-6961.0	3296.0
FGF9	2653.0	-2366.0
FGFR2	6750.0	6454.0
FLNA	-4704.0	7432.0
FLRT2	-5140.0	5982.0
FNBP1	-4982.0	-2153.0
FNBP1L	3122.0	4349.0
FOSL2	3909.0	5473.0
FOXC1	5241.0	-2301.0
FRY	7273.0	6809.0
FYN	-2200.0	6221.0
G0S2	4904.0	8051.0
GAB2	-717.0	7438.0
GADD45A	-1190.0	1738.0
GALC	-3406.0	-365.0
GAS1	7552.0	-2009.0
GDE1	5901.0	6082.0
GHR	-6922.0	4790.0
GJA1	-2103.0	-4151.0
GJA5	1705.0	2064.0
GLOD4	1193.0	3577.0
GLUD2	8064.5	3730.5
GLUL	7900.0	3064.0
GMDS	3172.0	2992.0
GMFB	-2893.0	4192.0
GNE	5717.0	4001.0
GPNMB	2911.0	-314.0
GPRC5A	-2287.0	6401.0
GRIK2	-1574.0	-5818.0
GRK5	280.0	5528.0
GTF2A2	505.0	6107.0
GULP1	3722.0	7458.0
GYG1	27.0	6415.0
HIRA	-6015.0	-99.0
HMCES	-1723.0	-1024.0
HMGN1	-2290.0	-3911.0
HMGN3	4379.0	6414.0
HNRNPA1	7891.0	-6290.0
HNRNPA3	-6985.0	8827.0
HNRNPC	-7051.0	8787.0
HNRNPDL	8075.0	2325.0
HOXA9	3263.0	751.0
HPGD	-6103.0	8382.0
HSP90AA1	-7286.0	8742.0
HSP90B1	-7279.0	8368.0
HSPA12A	-4571.0	1589.0
HSPA2	7012.0	5387.0
HSPA5	-7309.0	7589.0
HSPB11	3987.0	-4435.0
HTRA1	-6975.0	1980.0
IARS1	-5409.0	3400.0
IFI35	236.0	-2661.0
IFI44	-5838.0	5940.0
IFITM1	6414.0	8796.0
IGFBP2	3766.0	-1385.0
IGFBP7	-655.0	-4154.0
ING1	2867.0	3245.0
IQGAP2	8068.0	6890.0
IRS1	7064.0	-5549.0
ISG15	-1124.0	-2998.0
ITGA3	6960.0	5200.0
ITGAV	8155.0	2693.0
ITGB5	7359.0	1316.0
KANK1	-2615.0	-1388.0
KBTBD11	-5302.0	-5124.0
KCND3	-5750.0	7222.0
KIAA0232	-2998.0	4724.0
KIF5B	-1547.0	8819.0
KLHL9	-5268.0	6137.0
LANCL1	6816.0	-5515.0
LEPROT	7343.0	-34.0
LETMD1	5401.0	-3080.0
LITAF	8063.0	5645.0
LOX	7282.0	7922.0
LOXL1	6829.0	8361.0
LPL	-7356.0	1308.0
LRIG1	4468.0	-2718.0
LSR	-5031.0	150.0
LUC7L3	-5772.0	3514.0
MAFF	4078.0	3523.0
MAGI2	2368.0	-2330.0
MCL1	6260.0	-1020.0
MCM6	-6774.0	5231.0
MECP2	7588.0	-950.0
MED21	-6615.0	7431.0
MEGF9	6504.0	6830.0
MGAT5	-6087.0	2955.0
MME	-2831.0	3783.0
MORC3	-4342.0	8071.0
MSH2	7784.0	-3657.0
MTDH	2225.0	8064.0
MTHFD2	741.0	6092.0
MTSS1	-4717.0	-2278.0
MTX2	620.0	2417.0
MXRA8	-35.0	8623.0
MYH9	7189.0	7115.0
MYL9	3189.0	8125.0
MYLK	-7270.0	6685.0
MYO1B	1208.0	6584.0
MYO1E	-1541.0	-3326.0
N4BP1	-5080.0	168.0
N4BP2L1	6596.0	-3936.0
NAB1	-5905.0	8617.0
NAMPT	8078.0	8082.0
NAPG	3323.0	2180.0
NBN	-5298.0	8349.0
NDN	894.0	5072.0
NDRG1	-6340.0	1937.0
NECTIN2	8037.0	-2727.0
NEDD9	6142.0	8318.0
NEK7	-6954.0	8505.0
NFASC	-6650.0	-793.0
NFATC3	-5299.0	6496.0
NFE2L1	7245.0	5542.0
NMI	5088.0	-2764.0
NPHS1	8004.0	2268.0
NPTN	2459.0	6839.0
NR3C1	-2732.0	2240.0
NTRK2	-2163.0	86.0
NUPR1	6698.0	7199.0
OAS1	3456.0	-6726.0
OAS2	-6685.0	-1827.0
ODC1	-7155.0	3068.0
OPTN	8052.0	6703.0
OSER1	253.0	7396.0
OSMR	5259.0	8374.0
OTUD4	-4844.0	7588.0
PAFAH1B1	-3995.0	8266.0
PAK1	-886.0	5458.0
PALLD	-5124.0	-1144.0
PAM	2452.0	1723.0
PAPSS1	-2058.0	4960.0
PARD3	-6499.0	-3064.0
PARP1	134.0	473.0
PAWR	-2539.0	-5771.0
PCK1	6911.0	5688.0
PCMT1	766.0	5209.0
PDE4B	4858.0	7349.0
PDE4DIP	3763.0	6688.0
PDGFA	4317.0	4142.0
PDIA3	-7283.0	7821.0
PDLIM5	5446.0	6613.0
PEX14	5317.0	5271.0
PFN2	701.0	4388.0
PHLPP2	-4039.0	-122.0
PHYHIP	7368.0	-464.0
PLA2R1	-6067.0	7483.0
PLCE1	6100.0	6421.0
PLCG2	-5287.0	2474.0
PLOD2	-7324.0	3272.0
PLS3	-984.0	8476.0
PLSCR1	-6591.0	-6700.0
PLXNB2	3319.0	-3714.0
PNMA2	-2141.0	2522.0
PODXL	4742.0	7498.0
POSTN	-1531.0	-1183.0
PPFIA4	-4548.0	-3282.0
PPP2CB	5588.0	159.0
PRDX6	-3287.0	3877.0
PREPL	-6206.0	2850.0
PRKACB	569.0	661.0
PRKAR1A	3942.0	6647.0
PRKAR2B	-2382.0	-990.0
PRKCI	-1288.0	1225.0
PSMA2	-5464.5	6058.5
PSMA3	-3145.0	7801.0
PSMA6	-1954.0	8445.0
PSMB9	5987.0	-4708.0
PTGDS	4285.5	-1738.5
PTGER4	2504.0	1265.0
PTH1R	-5755.0	-4442.0
PTPN11	-3946.0	6142.0
PTPN14	5809.0	5132.0
PTPN7	-1757.0	-3829.0
PTPRD	5666.0	-327.0
PTPRO	6948.0	4311.0
RAB1A	-6571.0	7889.0
RAB21	-2903.0	7574.0
RABGAP1L	4836.0	6327.0
RAD23B	-6778.0	7740.0
RAI14	485.0	5278.0
RARRES2	2602.0	-1260.0
RBBP4	-6148.0	5835.0
RBMS1	-4349.0	7009.0
RCAN1	4520.0	2536.0
RDX	-6580.0	7989.0
RGS10	-3271.0	4787.0
RHOBTB2	4866.0	-6217.0
RNF11	-7128.0	7320.0
RPN2	-5521.0	3974.0
RSBN1	6236.0	5447.0
SACM1L	643.0	5177.0
SARAF	-5234.0	1625.0
SART3	1001.0	-2834.0
SCHIP1	3002.5	-1115.5
SCRN1	5367.0	1189.0
SDC2	-6850.0	7623.0
SDC4	6585.0	816.0
SEC61G	-2855.0	8720.0
SEMA3B	7901.0	-5165.0
SEMA3C	-6483.0	2704.0
SEMA5A	-5557.0	182.0
SEPTIN10	4833.0	4380.0
SEPTIN11	3452.0	5629.0
SEPTIN2	-3438.0	8730.0
SERINC1	-5903.0	6313.0
SERINC5	7586.0	448.0
SERPINE1	2322.0	8202.0
SET	-4660.5	2403.5
SGMS1	-3278.0	3419.0
SKP1	-6803.0	8394.0
SLK	8080.0	6197.0
SMARCA2	-7342.0	1064.0
SMARCC1	-4379.0	5036.0
SNX19	15.0	855.0
SPOCK2	5213.0	2612.0
SRGAP2	-1169.0	-688.0
SSBP2	440.0	2334.0
ST3GAL6	774.0	7961.0
STAT1	-3464.0	-4440.0
STX7	-3784.0	8359.0
SUB1	80.0	7679.0
SULF1	3980.0	4112.0
SULT1A2	3145.5	-3951.5
SYNPO	7369.0	5900.0
TAP1	5427.0	-6060.0
TAPBP	6125.0	-2067.0
TAX1BP1	3157.0	7948.0
TBC1D9B	471.0	2911.0
TBCA	-3096.0	8543.0
TCF21	1353.0	4314.0
TEAD4	-292.0	7230.0
TGFBR3	7234.0	4931.0
THSD7A	2585.0	6050.0
TIAL1	-5851.0	3033.0
TIMP1	-2454.0	3444.0
TLE4	3151.0	4968.0
TLK1	-4064.0	8347.0
TMED10	-6147.0	6432.0
TMED5	-2795.0	8686.0
TMEM123	5152.0	7162.0
TMEM259	-1139.0	-4368.0
TMX4	4757.0	3264.0
TNNT2	4843.0	-2318.0
TOB1	1023.0	6857.0
TOM1L2	7414.0	-6586.0
TOMM20	7388.0	3171.0
TOMM34	-4482.0	-2240.0
TOP2B	-411.0	8373.0
TRAM2	-6493.0	4494.0
TRIB2	-6029.0	3313.0
TRIM22	773.0	258.0
TRIM23	4542.0	6848.0
TRIM37	-6310.0	-2309.0
TRIM44	-6012.0	7523.0
TSC22D3	1663.0	5520.0
TSPAN3	-1044.0	865.0
TSPYL4	-3810.0	108.0
TUBB2A	1093.0	8351.0
TUSC3	-5686.0	4758.0
TYRO3	7595.0	256.0
UAP1	-7245.0	1255.0
UBE2D2	-935.0	6690.0
UBE2L6	809.0	5322.0
UBR2	-6912.0	-5650.0
UGCG	-6237.0	4297.0
UGP2	-6121.0	8636.0
ULK2	-6626.0	600.0
UNG	6140.0	-32.0
USP46	-5840.0	8296.0
USP9X	-5668.0	7709.0
VCAN	-3773.0	1454.0
VEGFA	-4619.0	-5156.0
VIM	5500.0	7940.0
VPS13D	-414.0	3107.0
VPS26A	-1189.0	7049.0
WARS1	2233.0	2888.0
WT1	5237.0	3586.0
WWP1	-6879.0	6537.0
XBP1	-7174.0	6737.0
XPO1	-6543.0	7447.0
XRCC5	-2388.0	162.0
YBX3	5916.0	4090.0
YWHAE	-2079.0	7315.0
YWHAZ	-5614.0	8512.0
ZBTB20	-6766.0	-328.0
ZC3HAV1	-469.0	-613.0
ZNF185	8131.0	3947.0
ZNF516	6822.0	1958.0

GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN

GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN
metric	value
setSize	179
pMANOVA	4.05e-19
p.adjustMANOVA	7.48e-18
s.dist	0.431
s.diabetes	-0.212
s.mitoG	0.375
p.diabetes	1.04e-06
p.mitoG	4.89e-18

Top 20 genes
Gene	diabetes	mitoG
HSPA4L	-7193	8500
CLOCK	-7043	8412
SAV1	-7082	8274
PSMD1	-6497	8619
CHD9	-6925	8050
UGP2	-6121	8636
PSMA1	-6705	7838
GTF2H1	-6106	8498
RPS6KA3	-6111	8270
MFAP3L	-7327	6664
GDI2	-5894	8074
DPP8	-5963	7906
VPS35	-5441	8535
PHF20L1	-5809	7968
RNFT1	-7085	6460
TRIM44	-6012	7523
SELENOP	-7347	6139
RC3H2	-5550	7956
USP9X	-5668	7709
DNM1L	-4825	8774

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCC3	8151.0	1041.0
ACSL5	6398.0	6307.0
ADGRE1	-6270.0	6567.0
ADIPOR2	-4637.0	5912.0
ADK	-3517.0	5789.0
AFTPH	-5292.0	7576.0
AHCYL1	-5585.0	5114.0
ANXA2	-337.0	8406.0
ANXA4	6843.0	3481.0
AP3B1	3159.0	1998.0
ARHGAP15	-1750.0	6480.0
ARHGEF12	-6487.0	5930.0
ARL6IP5	-696.0	6533.0
ARPC2	-4512.0	8767.0
ASAP1	-4994.0	4607.0
ASAP2	-833.0	6296.0
ASH1L	2351.0	7274.0
ATP2B4	7691.0	7255.0
ATP5F1C	164.0	8242.0
ATP6V1E1	-704.0	8548.0
BPTF	-4758.0	6405.0
C11orf49	4238.0	-2413.0
C21orf91	-4198.0	8254.0
CASP1	-1051.0	1558.0
CCNI	265.0	6150.0
CD53	-3501.0	7525.0
CDC40	1666.0	5218.0
CEMIP	6626.0	1672.0
CHD9	-6925.0	8050.0
CLDN6	-3611.0	-2444.0
CLEC4A	580.0	-5426.0
CLOCK	-7043.0	8412.0
CLTC	-4493.0	8248.0
CNOT1	-2585.0	3418.0
COMMD10	4464.0	3207.0
COPA	488.0	2943.0
CPQ	-7071.0	-13.0
CRK	-3124.0	6926.0
DAB2	-5689.0	1606.0
DENND1B	-3640.0	6236.0
DENND4C	-5667.0	856.0
DHTKD1	4800.0	-3721.0
DHX32	-759.0	5873.0
DNM1L	-4825.0	8774.0
DPP8	-5963.0	7906.0
EIF2S2	-3307.0	8799.0
EMSY	-4472.0	2078.0
EPS8	-6974.0	4802.0
ESD	771.0	8516.0
EXPH5	1020.0	7614.0
F13A1	3019.0	4962.0
FAM114A1	3334.0	8336.0
FBXO11	-2703.0	8171.0
FBXO9	-3297.0	-3812.0
FOXC1	5241.0	-2301.0
GABARAPL2	-1204.0	2829.0
GART	-5631.0	-3257.0
GCNT1	-6421.0	-331.0
GDAP2	1325.0	7455.0
GDI2	-5894.0	8074.0
GFOD2	714.0	-3471.0
GGPS1	-2197.0	7394.0
GMFG	3969.0	7186.0
GNL3L	-498.0	5906.0
GNPAT	-6628.0	-27.0
GSTO1	8023.0	4922.0
GTF2H1	-6106.0	8498.0
GUCY1A1	1918.0	7519.0
GUCY1B1	-1671.0	7666.0
HSPA4L	-7193.0	8500.0
ITGB5	7359.0	1316.0
ITPR2	4185.0	-2206.0
KCTD20	402.0	2843.0
KIAA0586	-3159.0	-2100.0
KLF6	145.0	7678.0
KLF7	-4593.0	8044.0
KPNA3	-1498.0	8389.0
L1TD1	437.0	-161.0
LAMTOR5	4258.0	4393.0
LEPROT	7343.0	-34.0
LGALS8	4547.0	6252.0
LHFPL6	-492.0	8054.0
LMBRD1	4227.0	4468.0
LPP	7785.0	3122.0
MCTP1	-5061.0	4365.0
MDH1	4402.0	4491.0
METTL9	-553.0	7370.0
MFAP3L	-7327.0	6664.0
MGST3	8217.0	479.0
MICU1	-552.0	6566.0
MINDY2	-6596.0	2386.0
MMRN1	202.0	7918.0
MPHOSPH6	-3203.0	7923.0
MR1	6506.0	5559.0
MRPS22	-6062.0	5844.0
MSH3	1132.0	-2806.0
MTF1	-4371.0	-3922.0
NCOA1	-3434.0	7005.0
NIT2	-5666.0	-1701.0
NOVA1	-2740.0	-4008.0
OSBPL1A	6468.0	6678.0
OXA1L	4609.0	-4940.0
PAPSS2	7044.0	-2227.0
PARP8	-7014.0	-116.0
PCNX1	7739.0	781.0
PDE8A	-3329.0	7592.0
PDXK	8266.0	-2949.0
PHF20L1	-5809.0	7968.0
PIAS1	3194.0	2440.0
POGLUT1	-1880.0	2758.0
PRKAG1	1680.0	-288.0
PRKCB	-5598.0	5660.0
PSMA1	-6705.0	7838.0
PSMA7	1612.0	7052.0
PSMC1	-1312.0	4327.0
PSMC2	-6765.0	4648.0
PSMD1	-6497.0	8619.0
PTER	-4312.0	3141.0
PURA	-6554.0	-808.0
PUS3	-4535.0	6560.0
RAB11FIP2	4139.0	931.0
RAB3GAP2	1771.0	-2399.0
RAD17	-430.0	6957.0
RBBP6	3444.0	5157.0
RBMS1	-4349.0	7009.0
RBPJ	2571.0	4528.0
RC3H2	-5550.0	7956.0
REL	-2309.0	7411.0
RHEB	-3280.0	-1691.0
RNF41	474.0	2919.0
RNFT1	-7085.0	6460.0
ROCK2	-1368.0	8738.0
RPL12	6107.0	-5604.0
RPS6KA3	-6111.0	8270.0
RPS6KA5	2516.0	-3206.0
RTCB	-1912.0	-1661.0
RUFY2	6866.0	4915.0
SAP18	-2023.0	7183.0
SAV1	-7082.0	8274.0
SCAF4	-1040.0	-4854.0
SCAMP1	7264.0	2855.0
SELENOP	-7347.0	6139.0
SELP	5864.0	2861.0
SERF2	-2395.0	-2526.0
SLC17A5	2333.0	243.0
SMAD1	5880.0	5459.0
SON	-1196.0	3884.0
SPARC	6297.0	8700.0
SPATS2L	-7291.0	4666.0
SRGAP2	-1169.0	-688.0
STAT3	8126.0	4982.0
STRADA	5090.0	-5448.0
STRN	-4029.0	6779.0
STX18	-6160.0	5652.0
STXBP5L	-7008.0	-3600.0
SYT11	727.0	3892.0
TANK	-4899.0	6416.0
TAX1BP1	3157.0	7948.0
TBC1D19	-6018.0	3271.0
TBC1D5	519.0	-4097.0
TIA1	-1179.0	-3112.0
TMEM50A	-5438.0	6054.0
TMF1	-1973.0	8658.0
TNFSF10	-6011.0	987.0
TOM1L1	-2990.0	3660.0
TPTE	-5920.5	6543.5
TRIM44	-6012.0	7523.0
TRPC4	-3076.0	-324.0
TUBD1	-1572.0	-5130.0
UBE2L3	-4226.5	5465.5
UGP2	-6121.0	8636.0
USP9X	-5668.0	7709.0
UVRAG	-5823.0	-64.0
VCL	-4796.0	7947.0
VPS35	-5441.0	8535.0
XAF1	-6155.0	1910.0
XK	-1266.0	5749.0
YIPF6	-4393.0	6442.0
ZNF318	-4818.0	-682.0

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP
metric	value
setSize	186
pMANOVA	8.32e-12
p.adjustMANOVA	1.03e-10
s.dist	0.307
s.diabetes	-0.0484
s.mitoG	0.304
p.diabetes	0.256
p.mitoG	9.83e-13

Top 20 genes
Gene	diabetes	mitoG
SUMO3	-7259	7825
TENT5A	-6948	8031
SERP1	-6709	8229
UGP2	-6121	8636
PSMA1	-6705	7838
MFAP3L	-7327	6664
ABCB7	-5950	8196
MYLK	-7270	6685
ATF4	-6143	7857
GDI2	-5894	8074
DPP8	-5963	7906
COPS2	-5385	8716
UCHL3	-5410	8491
RFTN1	-5652	7575
GMPS	-5160	8238
DNM1L	-4825	8774
EIF3E	-4677	8580
VCL	-4796	7947
SERINC3	-4809	7490
NCOA2	-5757	5994

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCB7	-5950.0	8196.0
AHCYL1	-5585.0	5114.0
ALDH6A1	-2335.0	6484.0
ALOX12	3935.0	-912.0
ANXA4	6843.0	3481.0
AP1S2	-2308.0	7787.0
ARHGAP6	-2621.0	1377.0
ARHGEF10L	-7201.0	-5313.0
ARL6IP5	-696.0	6533.0
ASAP2	-833.0	6296.0
ASL	7699.5	-4876.5
ASXL2	2377.0	3074.0
ATF4	-6143.0	7857.0
ATMIN	3967.0	-1041.0
ATP5F1C	164.0	8242.0
ATP5MG	5923.5	564.5
ATP5PO	6640.5	7456.5
AUTS2	6138.0	-5187.0
BIN2	-3519.0	1037.0
BTF3	-2304.0	8350.0
C1orf54	498.0	-619.0
C3	7675.0	3404.0
CAST	3920.0	8492.0
CELF2	-3363.0	6532.0
CFLAR	-4054.0	2224.0
CLNS1A	-2264.0	5698.0
CLPB	341.0	-4352.0
CLU	7398.0	5822.0
CMC4	-6293.0	4956.0
CNOT7	-4683.0	3410.0
COLQ	5431.0	-3281.0
COPA	488.0	2943.0
COPS2	-5385.0	8716.0
COX7A2	7439.0	-1673.0
CPNE3	1709.0	7633.0
CRYL1	7236.0	1237.0
CTSK	-3257.0	7753.0
CTTN	211.0	2434.0
DAB2	-5689.0	1606.0
DLG1	-1980.0	6587.0
DMAC2L	1623.0	-997.0
DNM1L	-4825.0	8774.0
DPP8	-5963.0	7906.0
EFHC2	4459.0	3227.0
EIF3E	-4677.0	8580.0
ENDOD1	-1447.0	6234.0
F13A1	3019.0	4962.0
FHL1	-7087.0	1776.0
GDI2	-5894.0	8074.0
GLG1	-3103.0	2134.0
GMPS	-5160.0	8238.0
GNAZ	-1947.0	4122.0
GNG11	-2960.0	5884.0
GUCY1A1	1918.0	7519.0
GUCY1B1	-1671.0	7666.0
HEBP1	8031.0	1621.0
HGD	-2104.0	3212.0
HIGD1A	359.0	-3963.0
HLA-DQB1	-4730.5	1217.5
HMGXB4	-4852.0	3401.0
HTATIP2	-3984.0	-543.0
IGF2BP3	-2484.0	-3959.0
IGFBP7	-655.0	-4154.0
IK	-4011.0	8357.0
IL12RB2	28.0	-159.0
IL1A	-1142.0	1688.0
IQCG	-2680.0	-3706.0
ITGA2B	4961.0	-4170.0
ITGB5	7359.0	1316.0
JTB	-4066.5	5444.5
KCMF1	-2107.0	6464.0
KIAA0319L	3653.0	-1408.0
KIF11	4262.0	-1098.0
KLC1	143.0	-5336.0
KYAT3	4242.0	3058.0
LAP3	-7119.0	4235.0
LEPROT	7343.0	-34.0
LPP	7785.0	3122.0
LY6H	2837.0	-6470.0
LY86	-3524.0	1844.0
MAPKAPK5	1373.0	5493.0
MCCC1	-5695.0	1708.0
MCTS1	761.0	2624.0
MCUR1	-1414.0	1795.0
ME2	6693.0	6628.0
MFAP3L	-7327.0	6664.0
MGLL	8090.0	5435.0
MMD	6600.0	8128.0
MRPS10	4929.0	5018.0
MRPS15	2010.0	4604.0
MSH3	1132.0	-2806.0
MTARC2	7913.0	384.0
MXI1	-2377.0	3008.0
MYG1	-658.0	-3758.0
MYH6	832.0	4629.0
MYL9	3189.0	8125.0
MYLK	-7270.0	6685.0
NACA	-4169.0	8236.0
NCAM1	-2962.0	3965.0
NCOA2	-5757.0	5994.0
NDRG2	-6784.0	2803.0
NDUFA9	3756.0	-5331.0
NDUFB5	450.0	2312.0
NDUFS4	4791.0	4043.0
NENF	-131.0	-4804.0
NREP	-6794.0	428.0
NRGN	-4483.0	579.0
OLA1	-105.0	6435.0
OXA1L	4609.0	-4940.0
P2RX7	4651.0	4591.0
PABPC1	-949.0	6861.0
PARL	7047.5	2790.5
PBX3	3107.0	6986.0
PDGFA	4317.0	4142.0
PEX26	6929.0	-6742.0
PFDN5	2482.0	8089.0
PGRMC1	8184.0	7942.0
PLPBP	-1323.0	520.0
PPBP	-5336.0	4394.0
PRKAR2B	-2382.0	-990.0
PROS1	4907.0	7279.0
PSMA1	-6705.0	7838.0
PSMA6	-1954.0	8445.0
PSMD2	-6702.0	-3836.0
PSME1	2907.0	5905.0
PSTPIP2	7077.0	1913.0
PTER	-4312.0	3141.0
PTGIR	-5223.0	4227.0
PTGS1	5729.0	6228.0
PTP4A2	3118.0	8121.0
RAB9A	-412.0	7818.0
RBBP6	3444.0	5157.0
REPS1	1567.0	6807.0
RFTN1	-5652.0	7575.0
RNASEH1	2749.5	-5225.5
RNF115	-528.0	6398.0
RO60	3028.0	8186.0
RRAGC	-2715.0	5320.0
RWDD1	-3923.0	7824.0
S100A10	7779.0	5985.0
SCAF4	-1040.0	-4854.0
SEPTIN2	-3438.0	8730.0
SERINC3	-4809.0	7490.0
SERP1	-6709.0	8229.0
SERTAD2	5977.0	1740.0
SFXN1	3455.0	7139.0
SKAP2	4178.0	4558.0
SLC25A5	7651.0	6887.0
SMAD1	5880.0	5459.0
SMAD2	2671.0	7154.0
SMAD7	-2050.0	-4957.0
SMG1	-4496.0	2722.0
SNX4	3343.0	8400.0
SNX6	-7210.0	1661.0
SOX4	-2131.0	5537.0
STX8	475.0	5557.0
STYXL1	5516.0	-5386.0
SUCLG1	1641.0	7641.0
SUMO3	-7259.0	7825.0
TAOK3	2465.0	-3763.0
TAP2	5211.5	-5555.5
TAX1BP1	3157.0	7948.0
TDRD3	1578.0	4847.0
TENT5A	-6948.0	8031.0
TEP1	7484.0	-6128.0
TMEM8B	6623.0	-4550.0
TMEM97	7621.0	4661.0
TNIK	2227.0	4457.0
TPM1	-4012.0	6903.0
TRIAP1	1250.0	184.0
TUBB1	-954.0	3430.0
UBE2D2	-935.0	6690.0
UBE2L3	-4226.5	5465.5
UCHL3	-5410.0	8491.0
UGP2	-6121.0	8636.0
UQCRB	-410.0	8334.0
UQCRC2	2236.0	6852.0
VCL	-4796.0	7947.0
XAF1	-6155.0	1910.0
XK	-1266.0	5749.0
YARS1	-6414.0	4044.0
ZBTB16	2742.0	1122.0
ZBTB20	-6766.0	-328.0
ZMAT3	8229.0	-3189.0
ZNF185	8131.0	3947.0
ZNF277	-6016.0	4145.0

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_1MONTH_POST_DX_UP

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_1MONTH_POST_DX_UP
metric	value
setSize	192
pMANOVA	1.16e-11
p.adjustMANOVA	1.07e-10
s.dist	0.313
s.diabetes	-0.106
s.mitoG	0.294
p.diabetes	0.0111
p.mitoG	2.31e-12

Top 20 genes
Gene	diabetes	mitoG
HNRNPA3	-6985	8827
HSP90B1	-7279	8368
CANX	-6936	8532
PDIA3	-7283	7821
TRAM1	-7037	8086
SUMO3	-7259	7825
PDIA4	-7329	7729
HSPA5	-7309	7589
PCNP	-6253	8734
RPN1	-7121	7464
ADAM10	-6444	8149
RNF11	-7128	7320
LYPLA1	-6790	7638
QKI	-6268	8165
YWHAZ	-5614	8512
GDI2	-5894	8074
EPRS1	-5855	8062
GALNT1	-6827	6806
BCAP31	-6657	6845
BTBD1	-5007	8727

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AAMP	69.0	-4287.0
AATF	2607.0	2827.0
ACO2	7295.0	7282.0
ACTG1	-1502.0	1482.0
ACTR2	-5189.0	7356.0
ADAM10	-6444.0	8149.0
ADNP2	2146.0	595.0
AGPS	-7336.0	594.0
AHCY	-3362.0	-6342.0
ALDOA	6979.5	3652.5
ANP32A	3020.5	6935.5
ANXA5	350.0	5743.0
ARL6IP1	-6592.5	-1456.5
ARPC4	3077.0	1525.0
ATMIN	3967.0	-1041.0
ATP5F1B	1691.0	1750.0
AZIN1	6036.0	4792.0
BAG1	2254.0	6318.0
BCAP31	-6657.0	6845.0
BMPR2	512.0	7927.0
BNIP2	3400.0	6267.0
BTBD1	-5007.0	8727.0
C8orf33	5060.0	-3701.0
CANX	-6936.0	8532.0
CD69	-4208.0	443.0
CHEK2	2232.0	922.0
CLN8	-367.0	-5559.0
CLP1	4455.0	-5275.0
COPA	488.0	2943.0
COPS7B	-2394.0	-5916.0
CORO1C	-6048.0	6789.0
CPNE3	1709.0	7633.0
CPSF6	-4618.0	2233.0
CSDE1	-3677.0	8769.0
CSNK1G3	-5311.0	8143.0
CYBB	-5520.0	5307.0
DAZAP2	5976.0	2413.0
DDIT4	5684.0	4879.0
DDX3X	3775.0	8058.0
DDX49	4404.0	-1145.0
DNAJA2	-3327.0	8515.0
DNAJB14	607.0	3352.0
DPYSL2	1058.0	7621.0
DR1	1246.0	8550.0
DUSP10	4557.0	5745.0
DUSP5	4923.0	4971.0
ECSIT	-3596.0	1408.0
EIF3I	5694.0	2343.0
EIF4G3	-7083.0	1872.0
ENSA	-1714.0	2979.0
EPRS1	-5855.0	8062.0
EZR	5644.0	6288.0
FAM13A	7985.0	1055.0
FARSA	-2969.0	-5485.0
FLI1	-110.0	7996.0
FOXK2	-5706.0	1999.0
G3BP2	-4462.0	5928.0
GALNT1	-6827.0	6806.0
GALNT12	6172.0	-2979.0
GDI2	-5894.0	8074.0
GLUD1	8064.5	3730.5
GLUD2	8064.5	3730.5
GPAA1	696.0	-5319.0
GPI	4816.0	5422.0
GSR	-2480.0	4329.0
HADHA	6883.0	5617.0
HIF1A	7374.0	8562.0
HMGB1	2876.0	8283.0
HNRNPA1	7891.0	-6290.0
HNRNPA3	-6985.0	8827.0
HNRNPD	6599.0	1068.0
HNRNPH2	-5391.0	5932.0
HNRNPM	-6548.0	-2929.0
HNRNPR	-3972.0	1045.0
HNRNPU	-5219.0	7082.0
HSP90B1	-7279.0	8368.0
HSPA5	-7309.0	7589.0
HSPA9	-566.0	8181.0
IDS	-4361.5	6034.5
IER5	5330.0	2127.0
ILVBL	3004.0	-6442.0
INPP5D	-1230.0	5535.0
ITGB3	1530.5	4298.5
JUN	581.0	5314.0
JUNB	4544.0	2430.0
KCTD3	6817.0	-4081.0
KDELR2	-4969.0	8520.0
KLF10	3691.0	2691.0
KPNB1	-1668.0	5829.0
LAPTM5	-5721.0	4643.0
LRIG2	-4032.0	2077.0
LSM12	-2869.0	4929.0
LSM14A	-4311.0	7661.0
LYPLA1	-6790.0	7638.0
MAP2K1	7852.0	3274.0
MAPK1IP1L	345.0	-2618.0
MAPRE1	-3633.0	8509.0
MATR3	5268.0	-4256.0
MBD2	-1599.0	7442.0
MDM4	-2223.0	-5305.0
MKRN1	-6560.0	3886.0
MRPL12	-2913.0	4144.0
MRPS10	4929.0	5018.0
MSN	-1294.0	5246.0
MTHFD1	7003.0	2637.0
NADSYN1	6875.0	-6478.0
NAPG	3323.0	2180.0
NCBP3	274.0	1327.0
NDUFV1	4313.0	-2431.0
NKAPD1	-880.0	7075.0
NNT	4576.0	4716.0
NPTN	2459.0	6839.0
NRAS	3837.0	7903.0
ODF2	8196.0	-5679.0
ORAI2	4113.0	4514.0
OSTF1	6553.0	5854.0
PABPC4	2846.0	-3784.0
PAK2	-4906.0	6708.0
PCBP2	6135.0	1313.0
PCNP	-6253.0	8734.0
PDIA3	-7283.0	7821.0
PDIA4	-7329.0	7729.0
PDZK1IP1	-3583.0	-2856.0
PIK3R1	-839.0	8363.0
PKN1	4322.0	-4516.0
PPP1CB	-4617.0	8661.0
PPP3CB	-1150.0	4729.0
PRIM2	-1544.0	-1595.0
PRKAA1	-4310.0	7164.0
PRKDC	-5092.0	3381.0
PSMC3	-4285.0	3386.0
PSMD2	-6702.0	-3836.0
PSPN	-1715.0	-1537.0
PTBP3	5856.0	7175.0
PTP4A2	3118.0	8121.0
QKI	-6268.0	8165.0
RAB40B	4958.0	-829.0
RBBP4	-6148.0	5835.0
RBM3	8175.0	5192.0
RBM39	-4400.0	4908.0
RNF11	-7128.0	7320.0
RNF38	2503.0	-1772.0
RNPS1	5559.0	6960.0
RPN1	-7121.0	7464.0
RTN3	-2760.0	5623.0
SAFB	-1933.0	-1132.0
SAFB2	3321.0	-6673.0
SART1	2632.0	-1920.0
SEC31A	835.0	-552.0
SFN	3916.0	5704.0
SFPQ	-5196.0	-4828.0
SIDT1	-2430.0	-1174.0
SIK1	3616.5	666.5
SLC35A2	2888.0	-5791.0
SLC35A3	-2157.0	4799.0
SLC39A7	-6230.0	880.0
SMARCA2	-7342.0	1064.0
SNTB2	5614.0	2572.0
SNX6	-7210.0	1661.0
SOX4	-2131.0	5537.0
SPCS3	4330.0	1501.0
SRRT	-6373.0	-1448.0
SRSF9	-2009.0	-5029.0
STAU1	-3137.0	6966.0
STK17B	-265.0	7680.0
STT3A	-6845.0	4709.0
STX8	475.0	5557.0
SUMO3	-7259.0	7825.0
SYNE2	-5553.0	2300.0
TAP2	5211.5	-5555.5
TENT5C	-779.0	7537.0
TMED2	-2351.0	6953.0
TMEM248	-5533.0	5899.0
TMEM9B	-4417.0	4027.0
TMOD3	576.0	8475.0
TOB1	1023.0	6857.0
TOMM22	-4533.0	5264.0
TPST2	5077.0	-171.0
TRAM1	-7037.0	8086.0
TRIM16	618.5	8118.5
TXNIP	2986.0	4021.0
UGCG	-6237.0	4297.0
UQCRC1	5627.0	1729.0
URI1	5037.0	3911.0
WDR18	-5000.0	-3150.0
WTAP	-3354.0	6889.0
XAB2	2873.0	3916.0
XRCC6	-1971.0	4034.0
YBX3	5916.0	4090.0
YWHAZ	-5614.0	8512.0
ZNF394	73.0	-278.0
ZNF551	-3852.0	2620.0

The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport
metric	value
setSize	168
pMANOVA	1.1e-08
p.adjustMANOVA	8.16e-08
s.dist	0.241
s.diabetes	0.162
s.mitoG	0.178
p.diabetes	0.000288
p.mitoG	7.32e-05

Top 20 genes
Gene	diabetes	mitoG
COX7B	6102.0	8760.0
ACO2	7295.0	7282.0
ATP5PO	6640.5	7456.5
UQCRQ	6271.0	7840.0
MT-ND5	6025.0	8007.0
ME2	6693.0	6628.0
PDK1	8236.0	5206.0
MT-ND1	5618.0	7323.0
MT-ND6	5059.0	8045.0
MT-CO1	6781.0	5983.0
COX6B1	5091.0	7299.0
NDUFA6	6990.0	5257.0
NDUFA12	4539.0	8087.0
NDUFV2	4127.0	8731.0
NDUFB8	4901.5	6790.5
PDP1	4298.0	7517.0
UCP2	6987.0	4595.0
ATP5PD	5135.0	6133.0
CS	5645.0	5457.0
NDUFA7	7477.5	4100.5

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ACAD9	-4848.0	-2818.0
ACO2	7295.0	7282.0
ADHFE1	-6733.0	240.0
ATP5F1A	6316.0	1471.0
ATP5F1B	1691.0	1750.0
ATP5F1C	164.0	8242.0
ATP5F1D	5225.0	673.0
ATP5F1E	6241.0	-5774.0
ATP5MC3	6278.0	-5724.0
ATP5ME	3268.0	3202.0
ATP5MF	6860.0	-1957.0
ATP5MG	5923.5	564.5
ATP5PB	1124.0	5544.0
ATP5PD	5135.0	6133.0
ATP5PF	710.0	7012.0
ATP5PO	6640.5	7456.5
BSG	-3166.0	5032.0
COQ10A	7831.0	-5063.0
COQ10B	219.0	7422.0
COX11	742.0	-1169.0
COX14	2703.0	-3376.0
COX16	-3433.0	7416.0
COX18	5019.0	1575.0
COX19	-2099.0	3124.0
COX20	-4714.0	6792.0
COX4I1	6324.0	-2473.0
COX5B	7740.0	-2295.0
COX6A1	5658.0	-2138.0
COX6B1	5091.0	7299.0
COX6C	7537.0	1755.0
COX7A2L	4007.0	4780.0
COX7B	6102.0	8760.0
COX7C	4066.0	-5285.0
COX8A	5622.0	-4787.0
CS	5645.0	5457.0
CYC1	7497.0	-4809.0
D2HGDH	-4629.0	-6471.0
DLAT	3962.0	2209.0
DLD	-2523.0	7607.0
DLST	6249.0	251.0
DMAC2L	1623.0	-997.0
ECSIT	-3596.0	1408.0
ETFA	-4953.0	3129.0
ETFB	5896.0	-2345.0
ETFDH	-5320.0	8131.0
FAHD1	-5635.0	4647.0
FH	1716.0	7771.0
GLO1	-6305.0	1741.0
GSTZ1	-3082.0	5598.0
HAGH	1822.0	7296.0
IDH2	155.0	1563.0
IDH3A	-958.0	7080.0
IDH3B	3081.0	573.0
IDH3G	-4880.0	6728.0
L2HGDH	1057.0	-1650.0
LDHA	-5897.0	843.0
LDHAL6B	2680.0	-6086.0
LDHB	5412.5	4669.5
LRPPRC	3831.0	6319.0
MDH2	3713.0	4456.0
ME1	-7337.0	4579.0
ME2	6693.0	6628.0
ME3	1300.0	-1217.0
MPC1	-3373.0	8178.0
MPC2	5946.0	-6209.0
MT-ATP6	-5818.0	8744.0
MT-ATP8	3277.0	6153.0
MT-CO1	6781.0	5983.0
MT-CO2	293.0	-1711.0
MT-CO3	2273.0	6269.0
MT-CYB	3577.0	8110.0
MT-ND1	5618.0	7323.0
MT-ND2	-1693.0	8626.0
MT-ND3	1835.0	8689.0
MT-ND4	1752.0	7883.0
MT-ND5	6025.0	8007.0
MT-ND6	5059.0	8045.0
NDUFA1	2104.0	-4989.0
NDUFA10	-1891.0	7765.0
NDUFA11	7279.5	474.5
NDUFA12	4539.0	8087.0
NDUFA13	4768.0	-2346.0
NDUFA2	5261.0	-6155.0
NDUFA3	4319.0	82.0
NDUFA4	-5102.0	8096.0
NDUFA5	7846.0	2875.0
NDUFA6	6990.0	5257.0
NDUFA7	7477.5	4100.5
NDUFA8	5308.0	4366.0
NDUFA9	3756.0	-5331.0
NDUFAB1	251.0	2742.0
NDUFAF1	-5470.0	1013.0
NDUFAF2	-2453.0	6013.0
NDUFAF3	-983.0	-2862.0
NDUFAF4	-5532.0	7346.0
NDUFAF5	1712.0	1907.0
NDUFAF6	-2110.0	-2934.0
NDUFAF7	1694.0	6697.0
NDUFB1	5672.0	711.0
NDUFB10	4853.0	-1340.0
NDUFB11	1539.0	7247.0
NDUFB2	2034.0	-5126.0
NDUFB3	-2553.0	-4632.0
NDUFB4	-5247.0	8719.0
NDUFB5	450.0	2312.0
NDUFB6	6783.0	848.0
NDUFB7	5336.0	2347.0
NDUFB8	4901.5	6790.5
NDUFB9	6765.0	1224.0
NDUFC1	1620.0	3968.0
NDUFC2	4564.5	-5546.5
NDUFS1	-1094.0	6402.0
NDUFS2	1841.0	4991.0
NDUFS3	4184.0	-2145.0
NDUFS4	4791.0	4043.0
NDUFS5	5126.0	-4249.0
NDUFS6	2287.0	6500.0
NDUFS7	7367.0	-5947.0
NDUFS8	1961.0	2910.0
NDUFV1	4313.0	-2431.0
NDUFV2	4127.0	8731.0
NDUFV3	-5257.0	5625.0
NNT	4576.0	4716.0
NUBPL	-1636.0	-1999.0
OGDH	6393.0	3583.0
PDHA1	-16.0	7978.0
PDHB	182.0	8175.0
PDHX	-1471.0	7544.0
PDK1	8236.0	5206.0
PDK2	8043.0	-1425.0
PDK3	-7135.0	6177.0
PDK4	3864.0	4092.0
PDP1	4298.0	7517.0
PDP2	-1525.0	-1465.0
PDPR	-1560.0	-1589.0
PM20D1	-4304.0	-1376.0
PPARD	-6955.0	-1980.0
RXRA	-5143.0	1552.0
SCO1	-3365.0	57.0
SCO2	-3687.0	2948.0
SDHA	3626.5	-1630.5
SDHB	3180.0	7355.0
SDHC	-860.0	834.0
SDHD	6887.5	1213.5
SLC16A1	-7027.0	5763.0
SLC16A3	5619.0	-3522.0
SLC16A8	87.0	-4934.0
SLC25A14	-1689.0	-3486.0
SLC25A27	1702.0	-2334.0
SUCLA2	-5284.0	8723.0
SUCLG1	1641.0	7641.0
SUCLG2	2515.0	3596.0
SURF1	2134.0	4131.0
TACO1	-3888.0	3315.0
TIMMDC1	-2651.0	-2924.0
TMEM126B	-6725.0	3713.0
TRAP1	-6124.0	2675.0
UCP2	6987.0	4595.0
UCP3	3545.0	-4364.0
UQCR10	6187.0	697.0
UQCR11	5012.5	-3179.5
UQCRB	-410.0	8334.0
UQCRC1	5627.0	1729.0
UQCRC2	2236.0	6852.0
UQCRFS1	3296.0	-3981.0
UQCRH	5780.5	-5189.5
UQCRQ	6271.0	7840.0
VDAC1	6.0	6549.0

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
metric	value
setSize	120
pMANOVA	5.69e-08
p.adjustMANOVA	3.51e-07
s.dist	0.274
s.diabetes	0.238
s.mitoG	0.137
p.diabetes	6.91e-06
p.mitoG	0.00966

Top 20 genes
Gene	diabetes	mitoG
COX7B	6102.0	8760.0
ATP5PO	6640.5	7456.5
UQCRQ	6271.0	7840.0
MT-ND5	6025.0	8007.0
MT-ND1	5618.0	7323.0
MT-ND6	5059.0	8045.0
MT-CO1	6781.0	5983.0
COX6B1	5091.0	7299.0
NDUFA6	6990.0	5257.0
NDUFA12	4539.0	8087.0
NDUFV2	4127.0	8731.0
NDUFB8	4901.5	6790.5
UCP2	6987.0	4595.0
ATP5PD	5135.0	6133.0
NDUFA7	7477.5	4100.5
MT-CYB	3577.0	8110.0
LRPPRC	3831.0	6319.0
SDHB	3180.0	7355.0
NDUFA8	5308.0	4366.0
NDUFA5	7846.0	2875.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ACAD9	-4848.0	-2818.0
ATP5F1A	6316.0	1471.0
ATP5F1B	1691.0	1750.0
ATP5F1C	164.0	8242.0
ATP5F1D	5225.0	673.0
ATP5F1E	6241.0	-5774.0
ATP5MC3	6278.0	-5724.0
ATP5ME	3268.0	3202.0
ATP5MF	6860.0	-1957.0
ATP5MG	5923.5	564.5
ATP5PB	1124.0	5544.0
ATP5PD	5135.0	6133.0
ATP5PF	710.0	7012.0
ATP5PO	6640.5	7456.5
COQ10A	7831.0	-5063.0
COQ10B	219.0	7422.0
COX11	742.0	-1169.0
COX14	2703.0	-3376.0
COX16	-3433.0	7416.0
COX18	5019.0	1575.0
COX19	-2099.0	3124.0
COX20	-4714.0	6792.0
COX4I1	6324.0	-2473.0
COX5B	7740.0	-2295.0
COX6A1	5658.0	-2138.0
COX6B1	5091.0	7299.0
COX6C	7537.0	1755.0
COX7A2L	4007.0	4780.0
COX7B	6102.0	8760.0
COX7C	4066.0	-5285.0
COX8A	5622.0	-4787.0
CYC1	7497.0	-4809.0
DMAC2L	1623.0	-997.0
ECSIT	-3596.0	1408.0
ETFA	-4953.0	3129.0
ETFB	5896.0	-2345.0
ETFDH	-5320.0	8131.0
LRPPRC	3831.0	6319.0
MT-ATP6	-5818.0	8744.0
MT-ATP8	3277.0	6153.0
MT-CO1	6781.0	5983.0
MT-CO2	293.0	-1711.0
MT-CO3	2273.0	6269.0
MT-CYB	3577.0	8110.0
MT-ND1	5618.0	7323.0
MT-ND2	-1693.0	8626.0
MT-ND3	1835.0	8689.0
MT-ND4	1752.0	7883.0
MT-ND5	6025.0	8007.0
MT-ND6	5059.0	8045.0
NDUFA1	2104.0	-4989.0
NDUFA10	-1891.0	7765.0
NDUFA11	7279.5	474.5
NDUFA12	4539.0	8087.0
NDUFA13	4768.0	-2346.0
NDUFA2	5261.0	-6155.0
NDUFA3	4319.0	82.0
NDUFA4	-5102.0	8096.0
NDUFA5	7846.0	2875.0
NDUFA6	6990.0	5257.0
NDUFA7	7477.5	4100.5
NDUFA8	5308.0	4366.0
NDUFA9	3756.0	-5331.0
NDUFAB1	251.0	2742.0
NDUFAF1	-5470.0	1013.0
NDUFAF2	-2453.0	6013.0
NDUFAF3	-983.0	-2862.0
NDUFAF4	-5532.0	7346.0
NDUFAF5	1712.0	1907.0
NDUFAF6	-2110.0	-2934.0
NDUFAF7	1694.0	6697.0
NDUFB1	5672.0	711.0
NDUFB10	4853.0	-1340.0
NDUFB11	1539.0	7247.0
NDUFB2	2034.0	-5126.0
NDUFB3	-2553.0	-4632.0
NDUFB4	-5247.0	8719.0
NDUFB5	450.0	2312.0
NDUFB6	6783.0	848.0
NDUFB7	5336.0	2347.0
NDUFB8	4901.5	6790.5
NDUFB9	6765.0	1224.0
NDUFC1	1620.0	3968.0
NDUFC2	4564.5	-5546.5
NDUFS1	-1094.0	6402.0
NDUFS2	1841.0	4991.0
NDUFS3	4184.0	-2145.0
NDUFS4	4791.0	4043.0
NDUFS5	5126.0	-4249.0
NDUFS6	2287.0	6500.0
NDUFS7	7367.0	-5947.0
NDUFS8	1961.0	2910.0
NDUFV1	4313.0	-2431.0
NDUFV2	4127.0	8731.0
NDUFV3	-5257.0	5625.0
NUBPL	-1636.0	-1999.0
PM20D1	-4304.0	-1376.0
SCO1	-3365.0	57.0
SCO2	-3687.0	2948.0
SDHA	3626.5	-1630.5
SDHB	3180.0	7355.0
SDHC	-860.0	834.0
SDHD	6887.5	1213.5
SLC25A14	-1689.0	-3486.0
SLC25A27	1702.0	-2334.0
SURF1	2134.0	4131.0
TACO1	-3888.0	3315.0
TIMMDC1	-2651.0	-2924.0
TMEM126B	-6725.0	3713.0
TRAP1	-6124.0	2675.0
UCP2	6987.0	4595.0
UCP3	3545.0	-4364.0
UQCR10	6187.0	697.0
UQCR11	5012.5	-3179.5
UQCRB	-410.0	8334.0
UQCRC1	5627.0	1729.0
UQCRC2	2236.0	6852.0
UQCRFS1	3296.0	-3981.0
UQCRH	5780.5	-5189.5
UQCRQ	6271.0	7840.0

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_UP

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_UP
metric	value
setSize	193
pMANOVA	1.45e-07
p.adjustMANOVA	7.66e-07
s.dist	0.231
s.diabetes	-0.00752
s.mitoG	0.231
p.diabetes	0.857
p.mitoG	3.4e-08

Top 20 genes
Gene	diabetes	mitoG
PTGES3	-7067	8733
HNRNPA3	-6985	8827
PDIA3	-7283	7821
SUMO3	-7259	7825
PDIA4	-7329	7729
RPN1	-7121	7464
RNF11	-7128	7320
LYPLA1	-6790	7638
QKI	-6268	8165
TWF1	-6517	7512
ATF4	-6143	7857
PTEN	-5726	8365
YWHAZ	-5614	8512
BTBD1	-5007	8727
DDX21	-5116	8276
SEC63	-4922	8290
PPP1CB	-4617	8661
ACTR2	-5189	7356
HNRNPU	-5219	7082
PAK2	-4906	6708

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AAMP	69.0	-4287.0
AATF	2607.0	2827.0
ACTG1	-1502.0	1482.0
ACTR2	-5189.0	7356.0
ADAM9	-5133.0	6361.0
ADNP2	2146.0	595.0
AGPS	-7336.0	594.0
AHCY	-3362.0	-6342.0
AKIRIN1	-211.0	8518.0
ALDOA	6979.5	3652.5
ANXA5	350.0	5743.0
ARHGAP26	-7093.0	2682.0
ATF3	-845.0	6400.0
ATF4	-6143.0	7857.0
ATMIN	3967.0	-1041.0
ATP1B3	-1025.0	8436.0
AZIN1	6036.0	4792.0
BHLHE40	-185.0	1804.0
BNIP2	3400.0	6267.0
BTBD1	-5007.0	8727.0
C8orf33	5060.0	-3701.0
CARF	1056.0	-3624.0
CD69	-4208.0	443.0
CHFR	686.0	5588.0
CIRBP	8197.0	-922.0
CKAP4	4629.0	6520.0
CLP1	4455.0	-5275.0
COPA	488.0	2943.0
COPS7B	-2394.0	-5916.0
COTL1	8183.0	-5409.0
CPNE3	1709.0	7633.0
CPSF6	-4618.0	2233.0
CREM	-3568.0	7564.0
CTSB	7086.0	-1439.0
CXCR4	4516.0	7547.0
CYBB	-5520.0	5307.0
DAZAP2	5976.0	2413.0
DDIT4	5684.0	4879.0
DDX21	-5116.0	8276.0
DDX3X	3775.0	8058.0
DNAJA2	-3327.0	8515.0
DOCK2	-5657.0	5085.0
DPYSL2	1058.0	7621.0
DUSP10	4557.0	5745.0
DUSP5	4923.0	4971.0
DUT	1159.0	688.0
ECPAS	2810.0	6759.0
ECSIT	-3596.0	1408.0
EIF4G3	-7083.0	1872.0
EIF4H	5370.0	-98.0
EPS15	-5197.0	5904.0
FAM53C	-5211.0	-2385.0
FEM1B	-180.0	4328.0
FLI1	-110.0	7996.0
G0S2	4904.0	8051.0
G3BP2	-4462.0	5928.0
GADD45B	7485.0	1360.0
GLUD1	8064.5	3730.5
GLUD2	8064.5	3730.5
GLUL	7900.0	3064.0
GNAI3	-3916.0	8277.0
GPI	4816.0	5422.0
HADHA	6883.0	5617.0
HAUS3	-3198.0	5697.0
HIF1A	7374.0	8562.0
HMGB1	2876.0	8283.0
HNRNPA1	7891.0	-6290.0
HNRNPA3	-6985.0	8827.0
HNRNPD	6599.0	1068.0
HNRNPH2	-5391.0	5932.0
HNRNPM	-6548.0	-2929.0
HNRNPU	-5219.0	7082.0
HSPA9	-566.0	8181.0
IER5	5330.0	2127.0
ILKAP	-3346.0	-3704.0
ILVBL	3004.0	-6442.0
IRF1	3086.0	3498.0
JUN	581.0	5314.0
JUNB	4544.0	2430.0
KIAA0930	4163.0	-2258.0
KLF10	3691.0	2691.0
KLF11	7284.0	1719.0
KLF9	3425.0	3735.0
KPNB1	-1668.0	5829.0
LAP3	-7119.0	4235.0
LAPTM5	-5721.0	4643.0
LSM12	-2869.0	4929.0
LYPLA1	-6790.0	7638.0
MAFF	4078.0	3523.0
MAPK1IP1L	345.0	-2618.0
MAPRE1	-3633.0	8509.0
MARCKS	-1781.0	5038.0
MBD2	-1599.0	7442.0
MFSD1	-2465.0	-4309.0
MKRN1	-6560.0	3886.0
MSN	-1294.0	5246.0
MTMR12	-4933.0	6552.0
MVP	6785.0	-5147.0
NADSYN1	6875.0	-6478.0
NAPG	3323.0	2180.0
NDUFV1	4313.0	-2431.0
NFKB2	2120.0	-4751.0
NFKBIA	1631.0	4830.0
NFKBIE	-4334.0	-123.0
NKAPD1	-880.0	7075.0
NPTN	2459.0	6839.0
NR4A2	-168.0	5972.0
NRIP1	-4907.0	6136.0
NUP93	5331.0	6196.0
ODF2	8196.0	-5679.0
OLA1	-105.0	6435.0
OSTF1	6553.0	5854.0
PABPC1	-949.0	6861.0
PABPC4	2846.0	-3784.0
PAK2	-4906.0	6708.0
PCBP2	6135.0	1313.0
PDIA3	-7283.0	7821.0
PDIA4	-7329.0	7729.0
PIGA	5537.0	-3293.0
PIGT	2201.0	-3364.0
PIK3R1	-839.0	8363.0
PKN1	4322.0	-4516.0
PLIN3	5004.0	-4323.0
PPFIA1	3451.0	-2521.0
PPP1CB	-4617.0	8661.0
PPP2R5E	5001.0	2898.0
PRMT7	5794.0	1791.0
PSMD2	-6702.0	-3836.0
PTEN	-5726.0	8365.0
PTGES3	-7067.0	8733.0
PTP4A1	6088.0	8315.0
QKI	-6268.0	8165.0
RAB5B	5887.0	3206.0
RAP2C	-4441.0	2874.0
RBM3	8175.0	5192.0
REEP4	3119.0	-2877.0
RETREG2	-3830.0	-5500.0
RIOK3	-3202.0	8097.0
RNASEH1	2749.5	-5225.5
RNF11	-7128.0	7320.0
RNF19B	-3119.0	-1959.0
RNF38	2503.0	-1772.0
RPN1	-7121.0	7464.0
RRAGD	7798.0	3815.0
RTN3	-2760.0	5623.0
SAFB	-1933.0	-1132.0
SAFB2	3321.0	-6673.0
SART1	2632.0	-1920.0
SCO2	-3687.0	2948.0
SCPEP1	4057.0	1287.0
SEC31A	835.0	-552.0
SEC63	-4922.0	8290.0
SF3A1	-4724.0	-831.0
SFN	3916.0	5704.0
SFPQ	-5196.0	-4828.0
SIK1	3616.5	666.5
SIL1	-5762.0	4185.0
SNF8	2397.0	-3270.0
SNX6	-7210.0	1661.0
SPCS3	4330.0	1501.0
SRRM1	5551.0	7062.0
SRSF9	-2009.0	-5029.0
STK17B	-265.0	7680.0
STRAP	1715.0	7369.0
SUCLG2	2515.0	3596.0
SUMO3	-7259.0	7825.0
TAOK3	2465.0	-3763.0
TAP2	5211.5	-5555.5
TERF2IP	-2169.0	2046.0
TESK2	2566.0	-4280.0
TMED2	-2351.0	6953.0
TNFAIP3	-151.0	2986.0
TOB1	1023.0	6857.0
TOM1	-2514.0	-174.0
TOR3A	6590.0	6359.0
TPD52L2	95.0	3488.0
TPST2	5077.0	-171.0
TSC22D3	1663.0	5520.0
TSR3	4228.0	-5856.0
TWF1	-6517.0	7512.0
TYMP	5612.0	-6441.0
UAP1	-7245.0	1255.0
UBAC1	6069.0	-2026.0
UQCRC1	5627.0	1729.0
USP7	-4172.0	7828.0
VDAC1	6.0	6549.0
WTAP	-3354.0	6889.0
XRCC6	-1971.0	4034.0
YBX3	5916.0	4090.0
YPEL5	8001.0	3939.0
YWHAZ	-5614.0	8512.0
ZNF394	73.0	-278.0
ZNF551	-3852.0	2620.0

GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN

GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN
metric	value
setSize	170
pMANOVA	4.3e-07
p.adjustMANOVA	1.99e-06
s.dist	0.259
s.diabetes	-0.119
s.mitoG	0.23
p.diabetes	0.00742
p.mitoG	2.38e-07

Top 20 genes
Gene	diabetes	mitoG
PNP	-7335.0	8459.0
DHX15	-6821.0	8710.0
ADAMTS1	-5452.0	8739.0
VPS35	-5441.0	8535.0
SEC23B	-6433.0	7123.0
RNFT1	-7085.0	6460.0
RLF	-6959.0	6399.0
USP9X	-5668.0	7709.0
PIK3CG	-5373.0	8065.0
DIS3	-6175.0	6931.0
ST8SIA4	-6249.0	6735.0
SRR	-5380.0	7655.0
AFTPH	-5292.0	7576.0
ARPC2	-4512.0	8767.0
TPTE	-5920.5	6543.5
CLTC	-4493.0	8248.0
KLF7	-4593.0	8044.0
MRPS22	-6062.0	5844.0
PUM2	-6583.0	5351.0
TLR6	-4778.0	7142.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABHD5	2617.0	5120.0
ACSL1	318.0	3006.0
ADAMTS1	-5452.0	8739.0
ADO	-1293.0	4866.0
AFTPH	-5292.0	7576.0
AGGF1	-5856.5	4390.5
ALOX5AP	-1117.0	7096.0
ALX1	-683.0	-381.0
ANAPC13	-4345.0	4356.0
ANKRD12	2891.0	7723.0
AP3B1	3159.0	1998.0
ARPC2	-4512.0	8767.0
ASH1L	2351.0	7274.0
ATG10	-442.0	4655.0
ATP6V1E1	-704.0	8548.0
B4GALT5	-7316.0	-2072.0
BMX	5552.0	4493.0
BTG2	6071.0	6308.0
C11orf49	4238.0	-2413.0
C3AR1	-1253.0	7488.0
CACNB2	5838.0	-5134.0
CAMK2A	-2272.0	4664.0
CCL8	2963.0	-1525.0
CCNJL	-3880.0	1011.0
CCR1	-3507.0	4981.0
CD53	-3501.0	7525.0
CDC123	1994.0	3040.0
CDC40	1666.0	5218.0
CDH10	-5060.0	-2946.0
CDH17	-1983.0	-292.0
CDKL3	3884.0	4697.0
CEMIP	6626.0	1672.0
CHTOP	-4615.0	-1316.0
CLTC	-4493.0	8248.0
COA3	1248.0	4406.0
COCH	-2313.0	1069.0
COG2	549.0	4121.0
CRYBG1	-6776.0	25.0
CSTF1	3995.0	1240.0
CYP4F12	7297.5	2796.5
DHX15	-6821.0	8710.0
DHX32	-759.0	5873.0
DIS3	-6175.0	6931.0
DNMBP	4678.0	6019.0
EDN1	-1177.0	7690.0
EGR1	1105.0	4313.0
EGR2	-1617.0	4130.0
EGR3	-3140.0	2625.0
EIPR1	-1798.0	3065.0
ELF1	-3303.0	7541.0
EMSY	-4472.0	2078.0
F2RL1	7281.0	4283.0
FABP7	-2994.0	-570.0
FAM114A1	3334.0	8336.0
FAS	3093.0	7580.0
FBXO9	-3297.0	-3812.0
FOXC1	5241.0	-2301.0
FZD7	4413.0	-2110.0
GCNT1	-6421.0	-331.0
GDAP2	1325.0	7455.0
GFOD2	714.0	-3471.0
GIGYF2	-6140.0	-70.0
GPR182	7524.0	5618.0
GYPA	-4292.0	6256.0
HINFP	297.0	1595.0
IL1B	-6242.0	3978.0
KCNJ1	-2062.0	3417.0
KCNJ15	-5752.0	2831.0
KIAA0319	1289.0	-5453.0
KLF6	145.0	7678.0
KLF7	-4593.0	8044.0
LIG4	-3349.0	7573.0
LIMK2	7085.0	-848.0
LMBRD1	4227.0	4468.0
LPAR6	-2000.0	-461.0
MACIR	-3913.0	-2181.0
MAFB	8140.0	2473.0
MAN2A1	8162.0	5453.0
MCL1	6260.0	-1020.0
MFAP3	2866.0	4624.0
MGAM	561.0	417.0
MKLN1	582.0	3529.0
MON2	-1660.0	-2065.0
MOSPD2	-1998.0	8209.0
MRPS22	-6062.0	5844.0
MTF1	-4371.0	-3922.0
MTHFS	179.5	-3965.5
MTO1	-6215.0	1994.0
MTOR	-4145.0	-2344.0
NAV2	-3698.0	-4133.0
NDEL1	206.0	1834.0
NOP10	2308.0	5890.0
NSUN3	595.0	3091.0
PAFAH1B1	-3995.0	8266.0
PCNX1	7739.0	781.0
PDE8A	-3329.0	7592.0
PEX3	453.0	6955.0
PFKM	5220.0	-2428.0
PIK3CG	-5373.0	8065.0
PIK3R4	4272.0	-1214.0
PKNOX2	5475.0	3240.0
PLIN2	3994.0	4652.0
PNP	-7335.0	8459.0
POGLUT1	-1880.0	2758.0
POLR2B	-675.0	5037.0
PRDM4	4788.0	2144.0
PROX1	7033.0	-3710.0
PSMA7	1612.0	7052.0
PTGS2	-2970.0	5783.0
PTPN21	2719.0	-4215.0
PTRH2	-3116.0	273.0
PUM2	-6583.0	5351.0
PUS3	-4535.0	6560.0
RAB11FIP2	4139.0	931.0
RAD17	-430.0	6957.0
RAE1	3041.0	-1934.0
RALGPS1	2494.0	-5324.0
RBM47	1021.0	-1394.0
RBMS1	-4349.0	7009.0
RBPJ	2571.0	4528.0
RGL1	-6436.0	-5685.0
RGS2	3150.0	1108.0
RHEB	-3280.0	-1691.0
RLF	-6959.0	6399.0
RNF17	-169.0	1065.0
RNF34	48.0	4672.0
RNFT1	-7085.0	6460.0
RPH3A	6618.0	-1014.0
RPS6KA5	2516.0	-3206.0
RTCB	-1912.0	-1661.0
SCRN3	-6919.0	2841.0
SCYL3	5375.0	225.0
SEC23B	-6433.0	7123.0
SGK1	4488.0	7322.0
SH2D3C	6944.0	958.0
SLC17A5	2333.0	243.0
SON	-1196.0	3884.0
SPARCL1	5687.0	8683.0
SRR	-5380.0	7655.0
ST8SIA4	-6249.0	6735.0
STRADA	5090.0	-5448.0
STXBP5L	-7008.0	-3600.0
SUOX	6862.0	-1063.0
TAX1BP1	3157.0	7948.0
TLR1	-3224.0	560.0
TLR2	5407.0	5188.0
TLR3	1181.0	6018.0
TLR6	-4778.0	7142.0
TLR8	281.0	6768.0
TNFAIP1	-1850.0	8190.0
TNFSF14	-1855.0	436.0
TP73	2068.0	84.0
TPTE	-5920.5	6543.5
TREML2	-3185.0	3037.0
TRIB1	7573.0	2586.0
USP10	-1816.0	-1370.0
USP9X	-5668.0	7709.0
USPL1	-6079.0	3330.0
UTP25	-910.0	-3889.0
UVRAG	-5823.0	-64.0
VNN1	6246.0	7250.0
VPS13D	-414.0	3107.0
VPS35	-5441.0	8535.0
WDFY3	-6210.0	-6585.0
WIPF2	4034.0	-1247.0
XRCC4	-4715.0	7026.0
ZBTB24	-5992.0	-4128.0
ZFYVE26	-1775.0	-6690.0
ZKSCAN4	-3447.0	-5890.0
ZNF654	-1490.0	8187.0

Activation of NF-kappaB in B cells

Activation of NF-kappaB in B cells
metric	value
setSize	66
pMANOVA	8.09e-07
p.adjustMANOVA	3.33e-06
s.dist	0.414
s.diabetes	-0.319
s.mitoG	0.265
p.diabetes	7.64e-06
p.mitoG	0.000202

Top 20 genes
Gene	diabetes	mitoG
PSMC6	-6851.0	8666.0
UBB	-7104.0	8341.0
PSME4	-6830.0	8511.0
SKP1	-6803.0	8394.0
PSMD1	-6497.0	8619.0
PSMD12	-6149.0	8628.0
PSMD7	-6943.0	7625.0
PSMA1	-6705.0	7838.0
UBC	-6013.0	8514.0
PSMC4	-6423.0	7920.0
PSMD14	-6080.0	8262.0
PSMD5	-6156.0	7150.0
PSMD6	-6385.0	6157.0
PSMD11	-6873.0	5201.0
PSMA2	-5464.5	6058.5
PRKCB	-5598.0	5660.0
CHUK	-3701.0	8556.0
PSMC2	-6765.0	4648.0
PSMB1	-5281.0	5936.0
PSMA5	-6660.0	4497.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
BCL10	-3598.0	5942.0
BTRC	3218.0	-5334.0
CARD11	-3020.0	3028.0
CHUK	-3701.0	8556.0
CUL1	-2997.0	6875.0
FBXW11	-3788.0	3125.0
IKBKB	-1785.0	-5829.0
IKBKG	3700.0	-677.0
MALT1	-2981.0	1806.0
MAP3K7	1594.0	7480.0
NFKB1	5449.0	4035.0
NFKBIA	1631.0	4830.0
NFKBIB	3850.0	467.0
NFKBIE	-4334.0	-123.0
PRKCB	-5598.0	5660.0
PSMA1	-6705.0	7838.0
PSMA2	-5464.5	6058.5
PSMA3	-3145.0	7801.0
PSMA4	-6074.0	4688.0
PSMA5	-6660.0	4497.0
PSMA6	-1954.0	8445.0
PSMA7	1612.0	7052.0
PSMA8	649.0	-4004.0
PSMB1	-5281.0	5936.0
PSMB10	3752.0	-908.0
PSMB11	1977.0	-5501.0
PSMB2	1472.0	-4144.0
PSMB3	-3388.0	5539.0
PSMB4	-4941.0	-5852.0
PSMB5	-1638.0	-2409.0
PSMB6	1806.0	-1845.0
PSMB7	-4628.0	-657.0
PSMB8	1080.0	-3793.0
PSMB9	5987.0	-4708.0
PSMC1	-1312.0	4327.0
PSMC2	-6765.0	4648.0
PSMC3	-4285.0	3386.0
PSMC4	-6423.0	7920.0
PSMC5	-4831.0	1120.0
PSMC6	-6851.0	8666.0
PSMD1	-6497.0	8619.0
PSMD10	-1613.0	2576.0
PSMD11	-6873.0	5201.0
PSMD12	-6149.0	8628.0
PSMD13	1898.0	5044.0
PSMD14	-6080.0	8262.0
PSMD2	-6702.0	-3836.0
PSMD3	-2532.0	-3242.0
PSMD4	-5648.0	4994.0
PSMD5	-6156.0	7150.0
PSMD6	-6385.0	6157.0
PSMD7	-6943.0	7625.0
PSMD8	1978.0	7546.0
PSMD9	7707.5	-894.5
PSME1	2907.0	5905.0
PSME2	1270.0	-4595.0
PSME3	752.0	7366.0
PSME4	-6830.0	8511.0
PSMF1	5087.0	4771.0
REL	-2309.0	7411.0
RELA	2579.0	-2368.0
RPS27A	-133.0	-1807.0
SKP1	-6803.0	8394.0
UBA52	7488.0	-4269.0
UBB	-7104.0	8341.0
UBC	-6013.0	8514.0

Respiratory electron transport

Respiratory electron transport
metric	value
setSize	99
pMANOVA	2.09e-06
p.adjustMANOVA	7.73e-06
s.dist	0.266
s.diabetes	0.221
s.mitoG	0.148
p.diabetes	0.000144
p.mitoG	0.0112

Top 20 genes
Gene	diabetes	mitoG
COX7B	6102.0	8760.0
UQCRQ	6271.0	7840.0
MT-ND5	6025.0	8007.0
MT-ND1	5618.0	7323.0
MT-ND6	5059.0	8045.0
MT-CO1	6781.0	5983.0
COX6B1	5091.0	7299.0
NDUFA6	6990.0	5257.0
NDUFA12	4539.0	8087.0
NDUFV2	4127.0	8731.0
NDUFB8	4901.5	6790.5
NDUFA7	7477.5	4100.5
MT-CYB	3577.0	8110.0
LRPPRC	3831.0	6319.0
SDHB	3180.0	7355.0
NDUFA8	5308.0	4366.0
NDUFA5	7846.0	2875.0
NDUFS4	4791.0	4043.0
COX7A2L	4007.0	4780.0
MT-ND3	1835.0	8689.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ACAD9	-4848.0	-2818.0
COQ10A	7831.0	-5063.0
COQ10B	219.0	7422.0
COX11	742.0	-1169.0
COX14	2703.0	-3376.0
COX16	-3433.0	7416.0
COX18	5019.0	1575.0
COX19	-2099.0	3124.0
COX20	-4714.0	6792.0
COX4I1	6324.0	-2473.0
COX5B	7740.0	-2295.0
COX6A1	5658.0	-2138.0
COX6B1	5091.0	7299.0
COX6C	7537.0	1755.0
COX7A2L	4007.0	4780.0
COX7B	6102.0	8760.0
COX7C	4066.0	-5285.0
COX8A	5622.0	-4787.0
CYC1	7497.0	-4809.0
ECSIT	-3596.0	1408.0
ETFA	-4953.0	3129.0
ETFB	5896.0	-2345.0
ETFDH	-5320.0	8131.0
LRPPRC	3831.0	6319.0
MT-CO1	6781.0	5983.0
MT-CO2	293.0	-1711.0
MT-CO3	2273.0	6269.0
MT-CYB	3577.0	8110.0
MT-ND1	5618.0	7323.0
MT-ND2	-1693.0	8626.0
MT-ND3	1835.0	8689.0
MT-ND4	1752.0	7883.0
MT-ND5	6025.0	8007.0
MT-ND6	5059.0	8045.0
NDUFA1	2104.0	-4989.0
NDUFA10	-1891.0	7765.0
NDUFA11	7279.5	474.5
NDUFA12	4539.0	8087.0
NDUFA13	4768.0	-2346.0
NDUFA2	5261.0	-6155.0
NDUFA3	4319.0	82.0
NDUFA4	-5102.0	8096.0
NDUFA5	7846.0	2875.0
NDUFA6	6990.0	5257.0
NDUFA7	7477.5	4100.5
NDUFA8	5308.0	4366.0
NDUFA9	3756.0	-5331.0
NDUFAB1	251.0	2742.0
NDUFAF1	-5470.0	1013.0
NDUFAF2	-2453.0	6013.0
NDUFAF3	-983.0	-2862.0
NDUFAF4	-5532.0	7346.0
NDUFAF5	1712.0	1907.0
NDUFAF6	-2110.0	-2934.0
NDUFAF7	1694.0	6697.0
NDUFB1	5672.0	711.0
NDUFB10	4853.0	-1340.0
NDUFB11	1539.0	7247.0
NDUFB2	2034.0	-5126.0
NDUFB3	-2553.0	-4632.0
NDUFB4	-5247.0	8719.0
NDUFB5	450.0	2312.0
NDUFB6	6783.0	848.0
NDUFB7	5336.0	2347.0
NDUFB8	4901.5	6790.5
NDUFB9	6765.0	1224.0
NDUFC1	1620.0	3968.0
NDUFC2	4564.5	-5546.5
NDUFS1	-1094.0	6402.0
NDUFS2	1841.0	4991.0
NDUFS3	4184.0	-2145.0
NDUFS4	4791.0	4043.0
NDUFS5	5126.0	-4249.0
NDUFS6	2287.0	6500.0
NDUFS7	7367.0	-5947.0
NDUFS8	1961.0	2910.0
NDUFV1	4313.0	-2431.0
NDUFV2	4127.0	8731.0
NDUFV3	-5257.0	5625.0
NUBPL	-1636.0	-1999.0
SCO1	-3365.0	57.0
SCO2	-3687.0	2948.0
SDHA	3626.5	-1630.5
SDHB	3180.0	7355.0
SDHC	-860.0	834.0
SDHD	6887.5	1213.5
SURF1	2134.0	4131.0
TACO1	-3888.0	3315.0
TIMMDC1	-2651.0	-2924.0
TMEM126B	-6725.0	3713.0
TRAP1	-6124.0	2675.0
UQCR10	6187.0	697.0
UQCR11	5012.5	-3179.5
UQCRB	-410.0	8334.0
UQCRC1	5627.0	1729.0
UQCRC2	2236.0	6852.0
UQCRFS1	3296.0	-3981.0
UQCRH	5780.5	-5189.5
UQCRQ	6271.0	7840.0

Gluconeogenesis

Gluconeogenesis
metric	value
setSize	30
pMANOVA	4.13e-06
p.adjustMANOVA	1.39e-05
s.dist	0.493
s.diabetes	0.482
s.mitoG	0.101
p.diabetes	4.87e-06
p.mitoG	0.337

Top 20 genes
Gene	diabetes	mitoG
ENO1	8244.0	7737.0
ALDOB	6728.0	7388.0
GOT1	7006.0	7048.0
PGAM2	7034.0	6971.0
PCK1	6911.0	5688.0
SLC25A12	7967.0	4933.0
GOT2	7334.0	4691.0
GPI	4816.0	5422.0
ALDOA	6979.5	3652.5
FBP1	7186.0	2802.0
MDH1	4402.0	4491.0
MDH2	3713.0	4456.0
FBP2	8143.0	1918.0
SLC37A4	5992.0	2463.0
PGAM1	1992.0	4530.0
SLC25A13	3242.0	999.0
SLC25A1	3746.0	544.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ALDOA	6979.5	3652.5
ALDOB	6728.0	7388.0
ALDOC	8058.0	-926.0
ENO1	8244.0	7737.0
ENO2	3279.0	-2394.0
ENO3	2281.0	-3777.0
FBP1	7186.0	2802.0
FBP2	8143.0	1918.0
G6PC	-4387.0	3036.0
G6PC3	-77.0	-5754.0
GAPDHS	-249.0	-6258.0
GOT1	7006.0	7048.0
GOT2	7334.0	4691.0
GPI	4816.0	5422.0
MDH1	4402.0	4491.0
MDH2	3713.0	4456.0
PC	-4135.0	-1520.0
PCK1	6911.0	5688.0
PCK2	7209.0	-2828.0
PGAM1	1992.0	4530.0
PGAM2	7034.0	6971.0
PGK1	-656.0	7226.0
SLC25A1	3746.0	544.0
SLC25A10	6761.5	-5719.5
SLC25A11	5582.0	-2414.0
SLC25A12	7967.0	4933.0
SLC25A13	3242.0	999.0
SLC37A1	6725.0	-4214.0
SLC37A2	-5241.0	4444.0
SLC37A4	5992.0	2463.0

BAELDE_DIABETIC_NEPHROPATHY_UP

BAELDE_DIABETIC_NEPHROPATHY_UP
metric	value
setSize	78
pMANOVA	0.000725
p.adjustMANOVA	0.00224
s.dist	0.226
s.diabetes	0.205
s.mitoG	0.0948
p.diabetes	0.00175
p.mitoG	0.148

Top 20 genes
Gene	diabetes	mitoG
CD34	7928.0	8147.0
ENO1	8244.0	7737.0
ENG	7600.0	8006.0
MT2A	8239.0	7031.0
PTGIS	7164.0	6579.0
MT1G	8262.0	5621.0
ZCCHC24	5250.0	8591.0
CLU	7398.0	5822.0
PTPRM	5478.0	7560.0
BBOX1	6577.0	5810.0
UNC5B	6777.0	5303.0
PECAM1	3970.0	8677.0
ADGRF5	4138.0	8117.0
PTPRB	3085.0	8717.0
FBP1	7186.0	2802.0
CRIP1	2892.5	6423.5
FAM53B	6631.0	2759.0
EML1	4749.0	3688.0
SLCO2A1	7840.0	2219.0
HYAL1	5242.0	3316.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AANAT	-796.0	2183.0
ACSM2A	-7294.5	1878.5
ACVRL1	-2455.0	7663.0
ACY1	-1207.5	-4016.5
ADAMTSL2	1075.0	7367.0
ADGRF5	4138.0	8117.0
ADGRG1	7358.0	493.0
AKR1A1	816.0	1669.0
ALDH4A1	3213.0	-5888.0
AOC1	5592.0	-5405.0
AQP1	6588.5	-2440.5
ARHGEF15	2583.0	849.0
ASS1	-6686.0	-610.0
ATP10B	-2699.0	3600.0
BAX	6141.0	-6683.0
BBOX1	6577.0	5810.0
BPHL	-6521.0	-4387.0
C4A	-311.5	-5183.5
CAPN3	3009.0	-6323.0
CCDC69	3036.0	-2502.0
CCND1	7933.0	-1628.0
CD34	7928.0	8147.0
CLU	7398.0	5822.0
CRIP1	2892.5	6423.5
CTSH	-6661.0	6547.0
CYP4F2	6042.0	596.0
DPEP1	1301.0	5412.0
EML1	4749.0	3688.0
ENG	7600.0	8006.0
ENO1	8244.0	7737.0
FAM53B	6631.0	2759.0
FBP1	7186.0	2802.0
FTL	-6693.0	-6771.0
FXYD2	-3344.5	4429.5
GAS2L1	-5204.0	-3783.0
GAS6	7430.0	-2362.0
GDPD5	7592.0	424.0
GGT1	-7165.0	-1432.0
GPLD1	1497.0	-753.0
HLA-DRB1	1762.5	-4711.5
HPN	-2955.0	-6509.0
HYAL1	5242.0	3316.0
HYAL2	-2781.0	-4258.0
ICAM2	-3483.0	7311.0
ID1	3953.0	-1529.0
IGFBP5	-3193.0	3366.0
IMPA2	7206.0	-2131.0
INPP5K	8149.0	-2011.0
ITFG2	826.0	-4600.0
ITM2A	-2572.0	4825.0
JADE3	2356.0	7037.0
MAP4	1438.0	8670.0
MIA2	-5486.0	8570.0
MT1G	8262.0	5621.0
MT2A	8239.0	7031.0
MT3	-369.0	-3432.0
MYC	1892.0	3123.0
PDE2A	3006.0	4319.0
PECAM1	3970.0	8677.0
PLPP3	-2151.0	8260.0
PPM1F	-571.0	446.0
PTGIS	7164.0	6579.0
PTPRB	3085.0	8717.0
PTPRM	5478.0	7560.0
RAMP2	4827.0	-1533.0
RBPMS	5172.0	810.0
SEMA6A	-6678.0	6683.0
SLC22A6	-3170.0	-395.0
SLCO2A1	7840.0	2219.0
SPG7	770.0	-5074.0
STARD8	3814.0	4312.0
TEK	-2265.0	8575.0
TIE1	-1857.0	8467.0
TLE2	-2153.0	-6181.0
UGT1A10	8268.5	-6174.5
UNC5B	6777.0	5303.0
VAT1	7581.0	-4263.0
ZCCHC24	5250.0	8591.0

GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP

GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP
metric	value
setSize	195
pMANOVA	0.00103
p.adjustMANOVA	0.00294
s.dist	0.158
s.diabetes	0.0321
s.mitoG	-0.154
p.diabetes	0.44
p.mitoG	0.000208

Top 20 genes
Gene	diabetes	mitoG
CCDC85B	7941	-6322
FUS	8128	-5908
ZNF512B	7028	-6394
NADSYN1	6875	-6478
CCS	6336	-6627
SNRPF	6058	-6379
ABHD17A	6198	-5972
PGLS	7748	-4404
MFSD10	6323	-5202
MED22	6145	-4961
PEX5	4872	-5747
DCAF15	5603	-4536
POLR2E	7128	-3504
TSR3	4228	-5856
AP5Z1	3582	-6569
SAFB2	3321	-6673
DAZAP1	5026	-4228
SAC3D1	4799	-4190
VPS51	3048	-6458
SNRNP70	2850	-6750

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AAMP	69.0	-4287.0
ABCF3	-1985.0	-3254.0
ABHD17A	6198.0	-5972.0
ADRM1	-6170.0	-477.0
AEBP1	7071.0	6822.0
AIP	-549.0	3479.0
AMBRA1	51.0	-5388.0
ANAPC2	-3336.0	-4659.0
ANTKMT	948.0	-6642.0
ANXA6	2396.0	7859.0
AP5Z1	3582.0	-6569.0
APBA3	-4271.0	-3239.0
ARF5	5403.0	222.0
ARHGAP17	-5151.0	-4644.0
ARHGAP4	2976.0	-5989.0
ARHGEF1	3750.0	-3695.0
ARPC4	3077.0	1525.0
ATP13A1	-1809.0	-4057.0
ATP1A1	8085.0	4179.0
ATP2A3	6309.0	8551.0
ATP5F1D	5225.0	673.0
AURKAIP1	4765.0	3868.0
BANF1	3561.0	-458.0
BRMS1	1673.0	7971.0
C9orf16	4926.0	854.0
CCDC22	-4166.0	-3221.0
CCDC85B	7941.0	-6322.0
CCS	6336.0	-6627.0
CD3E	-1202.0	619.0
CD7	-4515.0	2044.0
CD81	3188.0	6614.0
CDC37	-682.0	-4414.0
CDCA4	4122.0	2492.0
CDK2AP2	-6964.0	359.0
CDK9	315.0	-5322.0
CFDP1	-4681.0	7182.0
CFL1	-1720.0	8321.0
CLPTM1	-4205.0	3839.0
CNN2	-2669.0	6553.0
CNOT3	1322.0	-5732.0
COPG1	-3891.0	3599.0
COPS7B	-2394.0	-5916.0
CORO1A	-3183.0	-17.0
DAZAP1	5026.0	-4228.0
DCAF15	5603.0	-4536.0
DGKZ	-6561.0	-2123.0
DNAJC17	2361.0	3774.0
DNAJC7	-426.0	397.0
DRAP1	5968.0	6776.0
E4F1	-2515.0	-4079.0
EDF1	2958.0	-483.0
EEF1D	-4117.0	717.0
ERH	-4330.0	2173.0
ERP29	-6677.0	-3655.0
EXOC7	2029.0	3647.0
FABP5	3630.0	2188.0
FOXK2	-5706.0	1999.0
FUS	8128.0	-5908.0
GADD45GIP1	-3733.0	2788.0
GATAD2A	-190.0	5669.0
GCDH	1309.0	-1075.0
GPS2	1228.0	2826.0
GSN	7535.0	7997.0
GTF2H4	3818.0	-4105.0
GZMM	1140.0	-3497.0
H2AX	2476.0	-807.0
HDHD5	-3358.0	-6358.0
HMG20B	6566.0	-1264.0
HNRNPA2B1	-2132.0	-151.0
HNRNPK	-808.0	7246.0
HNRNPM	-6548.0	-2929.0
HRAS	1503.0	-318.0
HSPA9	-566.0	8181.0
HTRA2	3076.0	-6091.0
ILKAP	-3346.0	-3704.0
IMPDH2	4946.0	4658.0
IRF3	806.0	-4184.0
ITPKB	4042.0	6200.0
KLF13	8141.0	-719.0
LIMD2	2317.0	1635.0
LPCAT4	3374.0	1637.0
LRRC41	907.0	-3596.0
LSM12	-2869.0	4929.0
LSM14A	-4311.0	7661.0
MARCKSL1	-107.0	7707.0
MED22	6145.0	-4961.0
MFSD10	6323.0	-5202.0
MRPL12	-2913.0	4144.0
MRPS2	-5787.0	3563.0
MTA1	-1428.0	-2770.0
MZB1	2359.0	-2500.0
NAA60	-1707.0	521.0
NADSYN1	6875.0	-6478.0
NDUFC1	1620.0	3968.0
NELFB	-4499.0	-5790.0
NFKBIB	3850.0	467.0
NOC2L	-4670.0	1010.0
NONO	-5056.0	5895.0
OSBPL2	388.0	6106.0
PAF1	799.0	4723.0
PDAP1	3245.0	700.0
PDIA3	-7283.0	7821.0
PDIA4	-7329.0	7729.0
PDLIM2	6653.0	4632.0
PEF1	536.0	294.0
PEX5	4872.0	-5747.0
PFDN2	-1073.0	7198.0
PFDN6	2162.0	-2593.0
PFN1	-3462.0	-4129.0
PGLS	7748.0	-4404.0
PIN1	1926.0	-1497.0
POLD2	7422.0	3041.0
POLR2E	7128.0	-3504.0
PPIB	2973.0	133.0
PPP6R2	6009.0	-1355.0
PRCC	-3064.0	-3244.0
PRPF19	628.0	2226.0
PRPF31	-387.0	4117.0
PRR5	-6098.0	-5369.0
PSMB10	3752.0	-908.0
PTBP1	-4264.0	-2729.0
PTMA	-3664.0	8371.0
PTPN6	-1098.0	2140.0
PTPRCAP	-2234.0	-289.0
PUF60	-754.0	731.0
QTRT1	3026.0	-4577.0
RAB1B	-80.0	-4574.0
RALGDS	-3350.5	-786.5
RALY	-4431.0	5639.0
RASGRP2	-326.0	-409.0
RBM42	-841.0	-4924.0
RPL11	5748.0	1403.0
RPL36	7543.0	-2424.0
RPL37	2109.0	-667.0
RPLP2	3550.0	3555.0
RRS1	3598.0	556.0
RWDD1	-3923.0	7824.0
SAC3D1	4799.0	-4190.0
SAFB	-1933.0	-1132.0
SAFB2	3321.0	-6673.0
SART1	2632.0	-1920.0
SDF2L1	-7228.0	2132.0
SF3A2	1864.0	-5244.0
SF3B4	2644.0	-4321.0
SH3GLB2	284.0	-2915.0
SIGIRR	-826.0	-4627.0
SIPA1	-3901.0	3867.0
SLC25A22	-2818.0	4428.0
SLC39A4	4241.0	-90.0
SLC7A5	6666.0	-84.0
SMARCD2	-3787.0	113.0
SNF8	2397.0	-3270.0
SNRNP70	2850.0	-6750.0
SNRPF	6058.0	-6379.0
SPINT2	-1473.0	-4181.0
SREBF1	-2758.0	-4433.0
SRRM1	5551.0	7062.0
SRSF9	-2009.0	-5029.0
SSRP1	2663.0	4754.0
ST6GALNAC4	-365.0	4860.0
STARD3	-3871.0	-6390.0
STK25	6890.0	2565.0
TACC3	5297.0	4254.0
TAF10	-3030.0	2638.0
TAF1C	895.0	-5428.0
TAF4	2448.0	3472.0
TBL3	5799.0	-3253.0
TECR	1529.0	-251.0
THAP7	-4662.0	4597.0
THOC6	-3723.0	-3958.0
TKT	8181.0	2150.0
TLE5	376.0	3434.0
TMED9	-5309.0	-1036.0
TMEM259	-1139.0	-4368.0
TNFRSF14	872.0	-1648.0
TP53	2557.0	-3561.0
TRAPPC2	-3263.0	6403.0
TRIM28	-1390.0	-6154.0
TSPAN14	-6627.0	1158.0
TSR3	4228.0	-5856.0
TSSC4	-1289.0	-2173.0
TSTA3	4940.0	53.0
U2AF2	-2150.0	-825.0
UBE2M	3424.0	2257.0
UBE2S	4549.0	-1742.0
UBN1	-3031.0	-5794.0
UCP2	6987.0	4595.0
VPS51	3048.0	-6458.0
VPS9D1	-819.0	-4773.0
WDR18	-5000.0	-3150.0
WDR74	-544.0	3937.0
XAB2	2873.0	3916.0
YJU2	700.0	-3393.0
ZBTB17	2405.0	-590.0
ZNF512B	7028.0	-6394.0

GSE9006_TYPE_1_DIABETES_AT_DX_VS_4MONTH_POST_DX_PBMC_DN

GSE9006_TYPE_1_DIABETES_AT_DX_VS_4MONTH_POST_DX_PBMC_DN
metric	value
setSize	148
pMANOVA	0.00393
p.adjustMANOVA	0.0104
s.dist	0.141
s.diabetes	0.0865
s.mitoG	0.112
p.diabetes	0.0696
p.mitoG	0.0192

Top 20 genes
Gene	diabetes	mitoG
CA8	7188	8414
ATP2B4	7691	7255
CBR1	8220	6483
S100A10	7779	5985
ABHD6	6359	7038
RGS5	5300	8040
COL6A1	6555	6347
GSTO1	8023	4922
TIMM8A	4496	7741
RUFY2	6866	4915
LBP	4550	7403
ADAMTS5	4732	6838
SPSB1	7434	4252
RPL19	4654	6782
SELENOW	6572	4775
BMPR1B	5157	5691
TERF2	5515	5270
EIF3K	4728	6062
LPP	7785	3122
IFT46	5958	4026

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABHD6	6359.0	7038.0
ADAMTS5	4732.0	6838.0
ADGRA2	6742.0	-4913.0
ARFRP1	702.0	-6512.0
ARHGAP35	-2056.0	7180.0
ARMCX4	-5810.0	6643.0
ATAT1	-6757.0	-6199.0
ATP2B4	7691.0	7255.0
ATP5F1C	164.0	8242.0
ATXN3L	633.5	4150.5
BMPR1B	5157.0	5691.0
BOLA1	2756.0	-4124.0
C21orf91	-4198.0	8254.0
C2orf68	-4445.0	-3173.0
CA8	7188.0	8414.0
CBR1	8220.0	6483.0
CCDC51	3605.0	-4365.0
CCT5	-6746.0	6513.0
CD48	-1928.0	2626.0
CD52	-3982.0	3448.0
CD53	-3501.0	7525.0
CDKN2C	6608.0	-3067.0
CFAP43	-4048.0	2739.0
CHD9	-6925.0	8050.0
CNOT1	-2585.0	3418.0
COA4	-3012.0	3241.0
COL6A1	6555.0	6347.0
COMMD3	-4289.0	8822.0
COQ6	1950.0	-3453.0
COX4I1	6324.0	-2473.0
CSRNP2	6469.0	1246.0
DARS2	-5166.0	329.0
DNAJC28	3205.0	1021.0
DOCK3	-1237.0	4419.0
DYNLL1	-6952.0	7645.0
DYNLRB1	5057.0	-2847.0
DZANK1	5408.0	-4689.0
EEF1B2	1782.0	477.0
EIF2S2	-3307.0	8799.0
EIF3K	4728.0	6062.0
EPOR	7888.0	-2666.0
EPS8L3	3849.0	511.0
ESRP2	5000.0	-3533.0
FABP1	289.0	-1810.0
FAM111A	-3910.0	3549.0
FHOD3	7408.0	-6090.0
FMO4	7029.0	569.0
FOXO4	257.0	-4431.0
FZD5	2921.0	2259.0
GPR171	-4112.0	6669.0
GPR22	-1234.0	-3658.0
GRIA1	3840.0	-983.0
GSTO1	8023.0	4922.0
GUCY1A1	1918.0	7519.0
H2AW	-5259.0	4003.0
HAX1	-7176.0	4152.0
HECTD4	-439.0	-5909.0
HINT1	3946.0	413.0
HMGCL	1207.0	-3452.0
HOXC8	5791.0	-438.0
HPX	2769.0	2190.0
IER3IP1	-246.5	-3466.5
IFT46	5958.0	4026.0
ING4	-4464.0	-4099.0
INO80B	6545.5	-3302.5
ITFG2	826.0	-4600.0
LAMTOR5	4258.0	4393.0
LBP	4550.0	7403.0
LIF	352.0	2557.0
LIPE	2527.0	415.0
LMO4	-4999.0	1286.0
LPP	7785.0	3122.0
LRRC20	7602.0	-584.0
LRRC75B	-548.0	-2539.0
LSM1	1559.0	3093.0
MCCC1	-5695.0	1708.0
MDH1	4402.0	4491.0
MGST3	8217.0	479.0
MPV17	-5777.0	4042.0
MRPL17	-3013.0	6746.0
MRPL18	-4156.0	1438.0
MRPS33	-3942.0	3752.0
MYL7	6630.0	-336.0
NAP1L4	225.0	-2423.0
NDUFA3	4319.0	82.0
NRCAM	3619.0	5428.0
OXA1L	4609.0	-4940.0
PBLD	2456.0	-2483.0
PDE8A	-3329.0	7592.0
PFDN5	2482.0	8089.0
PGM3	-5155.0	-58.0
PHACTR4	420.0	3217.0
PHF11	-7148.0	3818.0
PIP4K2B	-937.0	1458.0
POGLUT1	-1880.0	2758.0
POLR2J	1742.0	3424.0
PPP2R5B	627.0	5414.0
PPT2	-5191.5	-2667.5
PRSS12	456.0	2357.0
RABEPK	2166.0	960.0
RABIF	-2521.0	-1135.0
RALYL	-4745.0	-993.0
RGS10	-3271.0	4787.0
RGS5	5300.0	8040.0
RNF113A	-3023.0	3421.0
RPA3	3029.0	1440.0
RPL12	6107.0	-5604.0
RPL19	4654.0	6782.0
RPL21	-1686.0	8463.0
RPL24	-409.0	6813.0
RPS13	7174.0	315.0
RPS16	6244.0	1119.0
RUFY2	6866.0	4915.0
RUFY3	5428.0	-5971.0
S100A10	7779.0	5985.0
SAP18	-2023.0	7183.0
SDHAF1	3386.0	2256.0
SELENOW	6572.0	4775.0
SEMA6A	-6678.0	6683.0
SEMA6C	6649.0	-2213.0
SERF2	-2395.0	-2526.0
SLC16A4	3434.0	6334.0
SLC35E2B	1081.0	797.0
SLC5A3	-5294.0	-1122.0
SLC66A1	-1315.0	-5738.0
SLC66A3	3663.0	5856.0
SNRPC	5050.0	2270.0
SNRPD2	2697.0	71.0
SOD3	-1080.0	-2376.0
SPSB1	7434.0	4252.0
SS18L2	2519.0	4485.0
SYNRG	-6000.0	2901.0
TAOK2	7040.0	-3998.0
TEP1	7484.0	-6128.0
TERF2	5515.0	5270.0
TFB1M	-154.0	-4984.0
TGFB3	-1546.0	8322.0
TIMM8A	4496.0	7741.0
TIMM8B	-1186.0	7371.0
TM6SF2	8051.0	1210.0
TNPO3	-3142.0	2781.0
TTC1	-896.0	7387.0
UBA52	7488.0	-4269.0
UQCR11	5012.5	-3179.5
VPS37A	-5968.0	8308.0
XCL1	-1812.5	2070.5
YIPF6	-4393.0	6442.0
ZMYM6	-6630.0	-5108.0

GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_DN

GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_DN
metric	value
setSize	179
pMANOVA	0.00515
p.adjustMANOVA	0.0127
s.dist	0.153
s.diabetes	-0.0842
s.mitoG	0.128
p.diabetes	0.0525
p.mitoG	0.00312

Top 20 genes
Gene	diabetes	mitoG
TOP1	-7160	8404
USO1	-6682	8749
RDX	-6580	7989
MANF	-7276	7166
SOS1	-6566	7698
GALNT1	-6827	6806
HDGF	-5612	7365
UBE2J1	-4894	8195
POMP	-6322	6114
ARF4	-6276	6071
ACOX1	-7025	5178
PDXDC1	-5276	6727
NFIL3	-7012	5060
LZTFL1	-4679	7473
SPTY2D1	-4612	7562
SRP72	-4187	8263
IDH3G	-4880	6728
IGF1	-6185	5101
PSMA5	-6660	4497
TFDP1	-6289	4476

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AAAS	5561.0	-2261.0
AARS1	-4867.0	5015.0
ACOX1	-7025.0	5178.0
ADRM1	-6170.0	-477.0
AGPS	-7336.0	594.0
AIFM1	-6115.0	-1984.0
ALDH18A1	140.0	-1710.0
ALG14	-5434.0	4618.0
ALG5	-3605.0	-1803.0
ALG9	-2677.5	-938.5
ARF4	-6276.0	6071.0
ARFGAP3	-1901.0	5934.0
ARHGDIA	7151.0	-2224.0
ATG13	1287.0	-2327.0
BAK1	7177.0	3473.0
BCAR3	5770.0	4210.0
BIN2	-3519.0	1037.0
BMP6	7829.0	1032.0
BRCA1	-2450.0	4279.0
BSCL2	4891.0	-4593.0
BSG	-3166.0	5032.0
BUD23	-342.0	-219.0
C20orf96	4344.0	-2715.0
CABLES1	5120.0	-5245.0
CACNB1	6319.0	483.0
CACNB3	7396.0	5397.0
CAMKK2	4860.0	-3845.0
CCNE2	2080.0	3324.0
CDC25A	-5099.0	1807.0
CDCA4	4122.0	2492.0
CDIPT	-719.0	3299.0
CENPA	-371.0	-2996.0
CENPI	-1339.0	-6050.0
CHST2	2012.0	6764.0
CKS2	2618.0	3705.0
CLDND1	-5798.0	2570.0
COPB1	-2848.0	7946.0
COX18	5019.0	1575.0
CRIP1	2892.5	6423.5
CYFIP1	3175.0	7476.0
DAXX	-867.0	1599.0
DENND1B	-3640.0	6236.0
DEPTOR	5474.0	3038.0
DUSP16	-3468.0	8092.0
ECH1	2316.0	6370.0
ECHS1	1581.0	1330.0
ECT2	-2506.0	1653.0
EDRF1	-2746.0	4436.0
EIF2AK3	-6386.0	3372.0
ENO1	8244.0	7737.0
FAM160B1	3255.0	5472.0
FAM214B	7990.0	-869.0
FBXW8	7356.0	-1698.0
FRRS1	-6261.0	1581.0
FTSJ1	-914.0	3461.0
GALNT1	-6827.0	6806.0
GBA	-5712.0	-3677.0
GBF1	-6681.0	3356.0
GEMIN7	-3021.0	21.0
GPN2	954.0	-3184.0
H2AZ1	-980.0	4206.0
HDGF	-5612.0	7365.0
HMGB2	6857.0	1304.0
HMOX2	-1566.0	6596.0
IARS1	-5409.0	3400.0
IDE	-1263.0	3492.0
IDH3G	-4880.0	6728.0
IFNAR1	-1479.0	4534.0
IGF1	-6185.0	5101.0
IQGAP2	8068.0	6890.0
IRF7	-4522.0	2058.0
JTB	-4066.5	5444.5
KCNN3	244.0	-1001.0
KIF4A	1014.0	6024.0
KLHDC4	1905.0	-1814.0
KNTC1	3675.0	-2190.0
LIN52	-355.0	4271.0
LZTFL1	-4679.0	7473.0
MAD2L1	4196.0	-2495.0
MAN2A1	8162.0	5453.0
MAN2B1	-3804.0	-5934.0
MANF	-7276.0	7166.0
MAPKAPK3	7267.0	-4297.0
MARS1	-1343.0	1975.0
MARVELD2	844.0	3416.0
MCAT	1596.0	-4830.0
MCRS1	3404.0	504.0
MDFIC	-2552.0	8519.0
MDH2	3713.0	4456.0
MDM2	5569.0	7967.0
METTL1	-871.0	-234.0
MFSD2A	-3164.0	-1561.0
MLEC	-7059.0	-620.0
MLKL	6050.0	1003.0
MLST8	-977.0	-1211.0
MRPL4	2533.0	-622.0
MT2A	8239.0	7031.0
MTRR	-1959.0	968.0
MYCBP	-2519.5	7901.5
N4BP2	6330.0	2179.0
NAGLU	-4620.0	-6515.0
NCALD	5836.0	5345.0
NCAPH	-438.0	2508.0
NDUFB7	5336.0	2347.0
NECAB3	4996.0	-2022.0
NEIL3	3195.0	-5023.0
NFIL3	-7012.0	5060.0
NFXL1	-6799.0	-2927.0
NOA1	-5924.0	890.0
NOD2	-6286.0	2681.0
OAS1	3456.0	-6726.0
OPTN	8052.0	6703.0
PAM	2452.0	1723.0
PDXDC1	-5276.0	6727.0
PGM3	-5155.0	-58.0
PIEZO1	8094.0	-2168.0
PIK3C2A	-262.0	8592.0
PIM1	-3615.0	5315.0
PKP4	-3865.0	5106.0
PLD3	5879.0	-2713.0
PLEKHA7	7220.0	-6755.0
PLK4	4005.0	1167.0
PMM2	-447.0	-333.0
PMVK	6667.0	-5342.0
POMP	-6322.0	6114.0
POU2AF1	-61.0	3658.0
PPAT	6637.0	6980.0
PRC1	669.0	103.0
PSEN2	-3057.0	-1025.0
PSMA5	-6660.0	4497.0
PSMD9	7707.5	-894.5
PTPN1	6946.0	3039.0
PTTG1	6122.5	3485.5
PYGB	5808.0	5273.0
RAB39B	-1021.0	6431.0
RANBP3	-167.0	2335.0
RBM47	1021.0	-1394.0
RDX	-6580.0	7989.0
RINT1	-2729.0	-5208.0
RTRAF	-2127.0	8772.0
SCAMP2	-1216.0	-2096.0
SDF2L1	-7228.0	2132.0
SEPHS1	2030.0	4351.0
SESN2	-4377.0	1285.0
SLC12A4	5724.0	5028.0
SLC17A9	3252.0	-4870.0
SLC2A8	8092.0	-6699.0
SLC35C1	-399.0	-4005.0
SLC35E1	-5606.0	67.0
SLFN13	-6911.0	2609.0
SND1	-6474.0	-3181.0
SOS1	-6566.0	7698.0
SPC24	5810.0	-1008.0
SPTY2D1	-4612.0	7562.0
SRP68	-2952.0	5498.0
SRP72	-4187.0	8263.0
SRPK1	-6945.0	287.0
SSR4	4091.0	1326.0
TFDP1	-6289.0	4476.0
TICRR	-474.0	-2001.0
TMED3	-6313.0	3992.0
TMEM184B	79.0	4353.0
TOP1	-7160.0	8404.0
TRIM47	-6869.0	-549.0
TUBG1	-743.0	6237.0
TWSG1	6722.0	5606.0
UAP1	-7245.0	1255.0
UBE2J1	-4894.0	8195.0
UBE2S	4549.0	-1742.0
UBE4A	-6479.0	2398.0
UBXN6	4514.0	6075.0
UCHL5	539.0	3983.0
ULK2	-6626.0	600.0
USO1	-6682.0	8749.0
XK	-1266.0	5749.0
YIF1B	5058.0	-3729.0
ZC3HAV1L	1390.0	-3103.0
ZDHHC9	-2745.0	-1163.0
ZNRD2	5305.0	-6074.0

HP_TYPE_I_DIABETES_MELLITUS

HP_TYPE_I_DIABETES_MELLITUS
metric	value
setSize	38
pMANOVA	0.0116
p.adjustMANOVA	0.0269
s.dist	0.252
s.diabetes	0.117
s.mitoG	0.224
p.diabetes	0.212
p.mitoG	0.017

Top 20 genes
Gene	diabetes	mitoG
EDA2R	8226	6933
MT-ND5	6025	8007
MT-ND1	5618	7323
MT-ND6	5059	8045
MT-CO1	6781	5983
EDA	4324	6384
MMP14	2752	7195
TKT	8181	2150
TCF4	2008	7220
MT-CO3	2273	6269
MT-ND4	1752	7883
MMP2	1375	7816
KCTD1	339	4479
DNAJC21	174	7090

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AIRE	2208.0	-3619.0
CAT	-602.0	4907.0
CLCNKB	8258.5	-2053.5
CNOT1	-2585.0	3418.0
CORIN	3128.0	-555.0
DNAJC21	174.0	7090.0
DNAJC3	-7149.0	8179.0
EDA	4324.0	6384.0
EDA2R	8226.0	6933.0
EFL1	-3377.0	4737.0
EIF2AK3	-6386.0	3372.0
FLT1	-4346.0	8420.0
FOXP3	2855.0	-5240.0
GPR35	-2136.0	5566.0
HNF1A	7450.0	-6675.0
ITCH	-4378.0	5792.0
KCTD1	339.0	4479.0
MMP14	2752.0	7195.0
MMP2	1375.0	7816.0
MST1	4315.0	-5473.0
MT-CO1	6781.0	5983.0
MT-CO2	293.0	-1711.0
MT-CO3	2273.0	6269.0
MT-ND1	5618.0	7323.0
MT-ND4	1752.0	7883.0
MT-ND5	6025.0	8007.0
MT-ND6	5059.0	8045.0
PSTPIP1	-1224.0	-988.0
SBDS	-2078.0	7401.0
SLC12A3	6051.0	-4654.0
SLC16A2	-6598.0	-2679.0
SRP54	-4728.0	8835.0
STAT1	-3464.0	-4440.0
STOX1	396.0	-1368.0
STUB1	4177.0	-2823.0
TCF4	2008.0	7220.0
TKT	8181.0	2150.0
TTC7A	7100.0	-5688.0

GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_UP

GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_UP
metric	value
setSize	187
pMANOVA	0.015
p.adjustMANOVA	0.0326
s.dist	0.132
s.diabetes	-0.0563
s.mitoG	0.119
p.diabetes	0.185
p.mitoG	0.00511

Top 20 genes
Gene	diabetes	mitoG
HNRNPA3	-6985	8827
HSP90B1	-7279	8368
PDIA3	-7283	7821
PDIA4	-7329	7729
HSPA5	-7309	7589
KLHL2	-6669	8214
RPN1	-7121	7464
ADAM10	-6444	8149
THBD	-6500	7788
YWHAZ	-5614	8512
PPP4R3A	-5758	7453
NSD1	-6917	6189
KDELR2	-4969	8520
CORO1C	-6048	6789
MSL2	-6222	6310
ACTR2	-5189	7356
HNRNPU	-5219	7082
P4HB	-6743	5398
RBBP4	-6148	5835
PAK2	-4906	6708

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AAMP	69.0	-4287.0
ABCF1	1824.0	-770.0
ABCF3	-1985.0	-3254.0
ACO2	7295.0	7282.0
ACTG1	-1502.0	1482.0
ACTR2	-5189.0	7356.0
ADAM10	-6444.0	8149.0
AGPAT3	-4447.0	-444.0
AGPS	-7336.0	594.0
AHCY	-3362.0	-6342.0
ALDOA	6979.5	3652.5
AMBRA1	51.0	-5388.0
AMDHD2	-5012.5	-6718.5
ANP32A	3020.5	6935.5
ARAF	4130.0	-5879.0
ARF6	-804.0	229.0
ARL6IP1	-6592.5	-1456.5
ARPC4	3077.0	1525.0
ATP2A2	-7302.0	1164.0
ATP5F1D	5225.0	673.0
ATP8B2	-690.0	6070.0
BANF1	3561.0	-458.0
BGLAP	-4940.0	-647.0
BMPR2	512.0	7927.0
BRMS1	1673.0	7971.0
BSG	-3166.0	5032.0
BTG1	7930.0	4557.0
CCDC22	-4166.0	-3221.0
CCL2	-1079.0	3167.0
CDC37	-682.0	-4414.0
CDCA4	4122.0	2492.0
CDK2	6186.0	-4240.0
CDK9	315.0	-5322.0
CDT1	6848.0	-4131.0
CHFR	686.0	5588.0
COPG1	-3891.0	3599.0
COPS7B	-2394.0	-5916.0
CORO1C	-6048.0	6789.0
CTSD	5035.5	6716.5
CXCR4	4516.0	7547.0
CYBA	-4719.0	-4200.0
CYBB	-5520.0	5307.0
CYP51A1	39.0	-254.0
DAZAP2	5976.0	2413.0
DDIT4	5684.0	4879.0
DDX3X	3775.0	8058.0
DGCR2	6927.0	-6630.0
DNAJA2	-3327.0	8515.0
DNAJC17	2361.0	3774.0
DUSP1	-2905.0	-1666.0
DUSP10	4557.0	5745.0
ECSIT	-3596.0	1408.0
EGLN1	-4261.5	-1804.5
EHD4	5130.0	8802.0
ELMO1	-4833.0	4917.0
EWSR1	7288.0	-6211.0
FARSA	-2969.0	-5485.0
FKBP5	6201.0	5807.0
FLI1	-110.0	7996.0
FZR1	3996.0	-5000.0
GALNT2	-4331.0	2581.0
GLOD4	1193.0	3577.0
GLUD1	8064.5	3730.5
GLUD2	8064.5	3730.5
GLUL	7900.0	3064.0
GOLPH3	-4347.0	6453.0
GPAA1	696.0	-5319.0
GPI	4816.0	5422.0
GRAMD4	-6920.0	-604.0
GSN	7535.0	7997.0
GSR	-2480.0	4329.0
HBEGF	-6694.0	-80.0
HERPUD1	924.0	3108.0
HLX	-778.0	6383.0
HMGB2	6857.0	1304.0
HNRNPA1	7891.0	-6290.0
HNRNPA3	-6985.0	8827.0
HNRNPK	-808.0	7246.0
HNRNPR	-3972.0	1045.0
HNRNPU	-5219.0	7082.0
HSP90B1	-7279.0	8368.0
HSPA5	-7309.0	7589.0
HSPA9	-566.0	8181.0
HYOU1	-7255.0	4009.0
IER3	2411.0	7011.0
IFIT3	4120.0	6607.0
IGKC	-2925.0	7318.0
ILF2	2872.0	3070.0
INTS3	-6130.0	-3040.0
JUNB	4544.0	2430.0
KDELR2	-4969.0	8520.0
KIF2C	2591.0	-1946.0
KIF4A	1014.0	6024.0
KLF2	3944.0	2031.0
KLHL2	-6669.0	8214.0
LSM12	-2869.0	4929.0
MAFB	8140.0	2473.0
MAP3K8	656.0	2671.0
MAP4K4	3979.0	7914.0
MAPRE1	-3633.0	8509.0
MARCKS	-1781.0	5038.0
MARCKSL1	-107.0	7707.0
MFN2	7230.0	-1391.0
MRPL12	-2913.0	4144.0
MSL2	-6222.0	6310.0
NAPG	3323.0	2180.0
NCAPH2	3662.0	-3375.0
NCL	6850.0	8762.0
NDUFV1	4313.0	-2431.0
NFE2L2	1459.0	8443.0
NFYA	-6056.0	1269.0
NRAS	3837.0	7903.0
NSD1	-6917.0	6189.0
NT5DC2	-7177.0	1331.0
ODF2	8196.0	-5679.0
OSTF1	6553.0	5854.0
P4HB	-6743.0	5398.0
PABPC4	2846.0	-3784.0
PAK2	-4906.0	6708.0
PDIA3	-7283.0	7821.0
PDIA4	-7329.0	7729.0
PDK4	3864.0	4092.0
PFN1	-3462.0	-4129.0
PHF21A	-2368.0	829.0
PIM1	-3615.0	5315.0
PPIB	2973.0	133.0
PPIF	6302.0	-1305.0
PPP4C	851.0	-5414.0
PPP4R3A	-5758.0	7453.0
PRCC	-3064.0	-3244.0
PRKDC	-5092.0	3381.0
PRPF6	3568.0	279.0
PSMC3	-4285.0	3386.0
PSPN	-1715.0	-1537.0
PTBP1	-4264.0	-2729.0
PTBP3	5856.0	7175.0
PTX3	-4488.0	-2545.0
PUF60	-754.0	731.0
RAB1B	-80.0	-4574.0
RAB8A	-855.0	2596.0
RABAC1	7530.0	-5906.0
RASA3	7998.0	3778.0
RBBP4	-6148.0	5835.0
RBM3	8175.0	5192.0
RBM42	-841.0	-4924.0
RCL1	5218.0	4620.0
REX1BD	1924.0	-3848.0
RPN1	-7121.0	7464.0
RRP12	3149.0	2306.0
RTN3	-2760.0	5623.0
SAFB	-1933.0	-1132.0
SAFB2	3321.0	-6673.0
SART1	2632.0	-1920.0
SEC31A	835.0	-552.0
SH3GLB2	284.0	-2915.0
SIDT1	-2430.0	-1174.0
SLC25A20	6499.0	4961.0
SLC39A7	-6230.0	880.0
SLC6A6	6597.0	-1579.0
SMU1	-2457.0	8160.0
SNRNP40	4613.0	2666.0
SOCS1	-253.0	-5520.0
SOCS3	4231.0	7185.0
SRSF9	-2009.0	-5029.0
STT3A	-6845.0	4709.0
STX11	608.0	-2244.0
SVIL	-3260.0	-6020.0
TBL3	5799.0	-3253.0
TESK2	2566.0	-4280.0
THBD	-6500.0	7788.0
THOC6	-3723.0	-3958.0
TMCO3	-7213.0	1883.0
TMEM160	7405.0	-6766.0
TMEM259	-1139.0	-4368.0
TMOD3	576.0	8475.0
TPD52L2	95.0	3488.0
TRAF3IP1	-3542.0	1244.0
TSC22D3	1663.0	5520.0
TSPAN14	-6627.0	1158.0
UBE2S	4549.0	-1742.0
UQCRC1	5627.0	1729.0
WDR18	-5000.0	-3150.0
WDR46	5078.0	-4710.0
XAB2	2873.0	3916.0
YBX3	5916.0	4090.0
YWHAZ	-5614.0	8512.0
ZFP36L1	-5993.0	4405.0

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_DN

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_DN
metric	value
setSize	162
pMANOVA	0.0169
p.adjustMANOVA	0.0348
s.dist	0.122
s.diabetes	0.0251
s.mitoG	0.12
p.diabetes	0.582
p.mitoG	0.00875

Top 20 genes
Gene	diabetes	mitoG
NAMPT	8078	8082
MAP3K20	8060	6853
G0S2	4904	8051
BLM	6861	5650
OSTF1	6553	5854
BTG2	6071	6308
S1PR1	4311	7637
SGK1	4488	7322
SLC25A20	6499	4961
STEAP4	4260	7386
F2RL1	7281	4283
SOCS3	4231	7185
MRAS	6507	4369
RCL1	5218	4620
RGCC	7096	3390
MCM3	3095	7219
BHLHE41	8219	2676
MANSC1	7247	3029
ST14	7899	2632
MAFB	8140	2473

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCA1	4025.0	-5420.0
ACKR4	4220.0	-5019.0
ACSL1	318.0	3006.0
ADGRG3	6332.0	-5786.0
ADO	-1293.0	4866.0
AKTIP	1278.0	6273.0
ALPL	7672.0	1079.0
AQP9	-5382.0	1990.0
ARHGDIG	7618.0	2364.0
ASPM	3924.0	-909.0
AURKA	514.0	6578.0
BASP1	-3933.0	3060.0
BHLHE41	8219.0	2676.0
BICDL1	-36.0	-2044.0
BLM	6861.0	5650.0
BSCL2	4891.0	-4593.0
BTG2	6071.0	6308.0
C11orf95	-1807.0	-875.0
C3AR1	-1253.0	7488.0
CCDC106	3305.0	-3283.0
CCL2	-1079.0	3167.0
CCNA2	4669.0	307.0
CCNB2	5920.0	-1519.0
CCR1	-3507.0	4981.0
CCR7	-4606.0	-4191.0
CCRL2	-518.0	4774.0
CD3EAP	3522.0	2248.0
CDC20	6493.0	-3052.0
CDH17	-1983.0	-292.0
CDK14	-2632.0	8039.0
CDK9	315.0	-5322.0
CEACAM4	463.5	-6623.5
CELSR1	8016.0	-4778.0
CHM	-4490.0	8464.0
CHTOP	-4615.0	-1316.0
CISH	-419.0	-2121.0
CKAP2	6527.0	-3445.0
COCH	-2313.0	1069.0
CORO1A	-3183.0	-17.0
CPT1A	5912.0	-394.0
CR2	-2478.0	2360.0
CSNK1D	-1602.0	2506.0
CWC25	1034.0	5526.0
CXCR2	-4298.0	3063.0
CYP4F3	9.0	6130.0
DBR1	985.0	3157.0
DHX32	-759.0	5873.0
DNAAF5	7068.0	-1825.0
DNAJC11	4115.0	1856.0
DUSP6	-5078.0	6412.0
EGLN1	-4261.5	-1804.5
EGR1	1105.0	4313.0
EGR2	-1617.0	4130.0
EGR3	-3140.0	2625.0
EHD1	-5018.0	2286.0
ELF1	-3303.0	7541.0
ELL2	-4455.0	7755.0
EZH2	13.0	1789.0
F2RL1	7281.0	4283.0
FOLR3	4808.5	-5490.5
FOSB	6048.0	-74.0
FRAT2	5931.0	-4034.0
G0S2	4904.0	8051.0
GAR1	642.0	-352.0
GIGYF2	-6140.0	-70.0
HEPH	-3944.0	6444.0
HLX	-778.0	6383.0
IER2	6951.0	-524.0
IGF2R	7820.0	-602.0
IGKC	-2925.0	7318.0
IL1B	-6242.0	3978.0
IL1R2	-2817.0	6793.0
INPP5D	-1230.0	5535.0
IRF4	-1439.0	-700.0
IVNS1ABP	7265.0	1321.0
KCNJ15	-5752.0	2831.0
KIAA0040	23.0	6781.0
KIAA0319	1289.0	-5453.0
KRT23	-660.0	3043.0
LCMT2	-6209.0	-5817.0
LDB1	7924.0	2101.0
LIG1	4884.0	892.0
LIMK2	7085.0	-848.0
LMTK2	-5556.0	-964.0
MAFB	8140.0	2473.0
MANSC1	7247.0	3029.0
MAP3K20	8060.0	6853.0
MAU2	4263.0	-5182.0
MCL1	6260.0	-1020.0
MCM3	3095.0	7219.0
MCRS1	3404.0	504.0
MEFV	-4277.0	5186.0
MGAM	561.0	417.0
MKLN1	582.0	3529.0
MME	-2831.0	3783.0
MRAS	6507.0	4369.0
MYC	1892.0	3123.0
MYNN	-1936.0	5744.0
MZB1	2359.0	-2500.0
NAMPT	8078.0	8082.0
NCAPG	3536.0	1273.0
NCF4	-5987.0	5579.0
NDEL1	206.0	1834.0
NFYA	-6056.0	1269.0
NRBF2	-6534.0	8395.0
NUTF2	-2549.0	1665.0
OLFM4	6940.0	-1244.0
OSBPL2	388.0	6106.0
OSTF1	6553.0	5854.0
PADI2	-2608.0	-2165.0
PARM1	-435.0	5897.0
PCBP4	5524.0	-5626.0
PDCD6	2803.0	5419.0
PDCL	-1384.0	7789.0
PDK4	3864.0	4092.0
PIK3CB	-1756.0	1880.0
PIM1	-3615.0	5315.0
PNP	-7335.0	8459.0
PPP1R10	4037.0	-3570.0
PTGS2	-2970.0	5783.0
PTPN21	2719.0	-4215.0
PTPRE	3132.0	1553.0
PYCR3	-6318.0	2115.0
RCL1	5218.0	4620.0
RGCC	7096.0	3390.0
RGS2	3150.0	1108.0
RRAGA	-3310.0	5815.0
S100A8	-3981.0	6893.0
S1PR1	4311.0	7637.0
SELL	-4022.0	902.0
SEMA4D	-573.0	-5740.0
SGK1	4488.0	7322.0
SLC19A1	4798.0	-4123.0
SLC25A20	6499.0	4961.0
SLPI	307.0	3136.0
SNX19	15.0	855.0
SOCS3	4231.0	7185.0
SPAG8	2548.0	-5221.0
SPATA2L	2799.0	-4361.0
ST14	7899.0	2632.0
ST8SIA4	-6249.0	6735.0
STEAP4	4260.0	7386.0
SVIL	-3260.0	-6020.0
TBC1D9	3187.0	4014.0
THBD	-6500.0	7788.0
THRAP3	6727.0	760.0
TLR1	-3224.0	560.0
TLR6	-4778.0	7142.0
TMEM185B	-4851.0	-3834.0
TNFAIP6	-3592.0	4376.0
TRAF3	-6416.0	5442.0
TREM1	169.0	-2242.0
TREML2	-3185.0	3037.0
TRIB1	7573.0	2586.0
UBAP1	-6158.0	7653.0
USP20	-4736.0	-5752.0
WDR3	-6076.0	2575.0
WIPI2	-3357.0	-5676.0
ZFP30	-521.0	-3488.0
ZFP36	-1295.0	1383.0
ZHX2	-7088.0	76.0
ZNF654	-1490.0	8187.0

GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_UP

GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_UP
metric	value
setSize	167
pMANOVA	0.0288
p.adjustMANOVA	0.0561
s.dist	0.117
s.diabetes	-0.00264
s.mitoG	0.117
p.diabetes	0.953
p.mitoG	0.00893

Top 20 genes
Gene	diabetes	mitoG
TENT5A	-6948	8031
ACOT9	-5708	8538
ATF4	-6143	7857
CTAGE1	-5486	8570
CPPED1	-6207	6376
DNAJC2	-5076	7232
KITLG	-4636	7908
PLXNC1	-5669	5576
BCL2A1	-5733	5402
RBMS1	-4349	7009
DNAJC1	-6576	4427
DOCK2	-5657	5085
ZBP1	-6151	4520
CREM	-3568	7564
COX16	-3433	7416
TFRC	-4827	4702
FLRT3	-4355	5017
OR7E24	-4864	4086
PIM1	-3615	5315
IL1R2	-2817	6793

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AATF	2607.0	2827.0
ACOT9	-5708.0	8538.0
ADCK2	-2442.0	-5853.0
ADGRA2	6742.0	-4913.0
ADM	7469.0	6606.0
AEN	7917.0	1933.0
ALOX5	5079.0	-1468.0
ANXA3	4126.0	8240.0
AQP9	-5382.0	1990.0
ARHGAP26	-7093.0	2682.0
ARHGEF16	1946.0	1028.0
ASPM	3924.0	-909.0
ATF4	-6143.0	7857.0
ATG2A	6419.0	-6384.0
B3GNT4	1421.0	-968.0
BCL2A1	-5733.0	5402.0
BCL6	-4525.0	36.0
BMP2	4300.0	7938.0
CAMK2N1	-5811.0	179.0
CAPN3	3009.0	-6323.0
CARS2	-4415.0	-4360.0
CBX6	3215.0	-5159.0
CCNJ	4191.0	-1046.0
CD2BP2	5662.0	-4064.0
CD83	-913.0	5700.0
CEACAM8	3793.5	5357.5
CHAF1A	7526.0	-1172.0
COL8A2	1170.0	2569.0
COX16	-3433.0	7416.0
CPPED1	-6207.0	6376.0
CREM	-3568.0	7564.0
CRYBG3	5850.0	7100.0
CTAGE1	-5486.0	8570.0
CTRL	3393.0	-4720.0
CTSZ	-2861.0	2478.0
CYP3A7	399.0	1822.0
DHCR24	-3812.0	-2962.0
DIP2A	7923.0	-2097.0
DLX6	-4732.0	-216.0
DNAJC1	-6576.0	4427.0
DNAJC2	-5076.0	7232.0
DOCK2	-5657.0	5085.0
DOCK5	-5552.0	-1658.0
EFCAB11	1535.0	-3457.0
EGLN3	7904.0	4308.0
EMILIN2	-3487.0	2545.0
ENC1	6176.0	4284.0
EYA1	-271.0	1524.0
FAM13A	7985.0	1055.0
FIG4	-2261.0	2661.0
FLRT3	-4355.0	5017.0
FUT4	2474.0	-2219.0
GCNT4	7870.0	5943.0
GMDS	3172.0	2992.0
GNG10	5845.0	2921.0
GNG12	-1212.0	6898.0
GPC5	-4977.0	-3337.0
GPR12	-4047.0	-1246.0
GPR137B	-7258.0	-935.0
GRAMD1B	919.0	-2556.0
GRAMD4	-6920.0	-604.0
GUCY1A1	1918.0	7519.0
HIC2	6652.0	-6089.0
HK3	-4874.0	2139.0
HLX	-778.0	6383.0
ICAM4	997.0	2998.0
IER3	2411.0	7011.0
IFIT3	4120.0	6607.0
IL1R2	-2817.0	6793.0
IL33	7328.0	7911.0
IMPDH1	1190.0	4821.0
INPP5A	5585.0	6455.0
IRF1	3086.0	3498.0
KAZALD1	-290.0	1843.0
KBTBD11	-5302.0	-5124.0
KIAA0232	-2998.0	4724.0
KITLG	-4636.0	7908.0
KLF4	5830.0	7414.0
KLHL36	2189.0	-5945.0
KPTN	3882.0	-3219.0
LDLR	4229.0	3193.0
LETM1	-2711.0	2319.0
LIN7A	-84.0	-4388.0
LRRFIP2	-2647.0	2384.0
LUM	4367.0	7749.0
MAF	-4741.0	-4090.0
MAFF	4078.0	3523.0
MAP3K20	8060.0	6853.0
MCUR1	-1414.0	1795.0
MGAM	561.0	417.0
MME	-2831.0	3783.0
MNT	3097.0	-5444.0
MRAS	6507.0	4369.0
MTARC2	7913.0	384.0
MTF1	-4371.0	-3922.0
MYBBP1A	4445.0	965.0
NADSYN1	6875.0	-6478.0
NAMPT	8078.0	8082.0
NECTIN3	-6346.0	525.0
NFKBIA	1631.0	4830.0
NFKBIE	-4334.0	-123.0
NID2	-2779.0	3823.0
NLRP3	-5337.0	1863.0
NOC2L	-4670.0	1010.0
NPC2	3922.0	3679.0
NUFIP1	4885.0	5778.0
NUP93	5331.0	6196.0
OBSL1	-2821.0	4269.0
OR7E24	-4864.0	4086.0
P2RY2	7810.0	1570.0
PABPC1	-949.0	6861.0
PIGT	2201.0	-3364.0
PIM1	-3615.0	5315.0
PLPPR4	6130.0	5171.0
PLXNC1	-5669.0	5576.0
PRKD1	-339.0	4350.0
PTP4A1	6088.0	8315.0
PTX3	-4488.0	-2545.0
PYGL	6729.0	1748.0
R3HCC1	7667.0	-1069.0
RAP2C	-4441.0	2874.0
RASSF9	2702.0	6648.0
RBMS1	-4349.0	7009.0
RFX4	7908.0	-2857.0
RXRA	-5143.0	1552.0
SAT1	5606.0	7029.0
SCCPDH	554.0	-3193.0
SCO2	-3687.0	2948.0
SERPINA1	8234.0	4905.0
SGK1	4488.0	7322.0
SLC19A1	4798.0	-4123.0
SLC22A4	6314.0	-3631.0
SLC30A9	2912.0	4119.0
SLC39A9	-4297.0	-1684.0
SMURF1	7065.0	-1671.0
SPRED2	-1328.0	-5582.0
SPTLC2	-735.0	-2873.0
SRGAP2	-1169.0	-688.0
STX4	-3184.0	-4491.0
SUSD5	2305.0	718.0
TALDO1	-5386.0	449.0
TAS2R4	3211.0	545.0
TAX1BP3	5769.0	6972.0
TBC1D17	6335.0	-6244.0
TCIRG1	-5363.0	-3931.0
TENT5A	-6948.0	8031.0
TEX2	-3123.0	4517.0
TFRC	-4827.0	4702.0
TIAL1	-5851.0	3033.0
TLR1	-3224.0	560.0
TMEM254	-7257.0	-5697.0
TMEM255A	3314.0	2481.0
TNF	-2778.0	4883.0
TNFAIP6	-3592.0	4376.0
TPMT	-2094.0	4118.0
TRDN	-6980.0	2227.0
TRIB1	7573.0	2586.0
TRIL	-3580.0	4278.0
TSPAN9	4143.0	3244.0
TYR	1845.0	-4177.0
UPP1	5774.0	8231.0
USP13	-642.0	3525.0
WWP2	5708.0	-972.0
ZBP1	-6151.0	4520.0
ZNF280B	-4822.0	3198.0
ZNF287	2256.0	2713.0
ZNF394	73.0	-278.0

HP_NEPHROPATHY

HP_NEPHROPATHY
metric	value
setSize	90
pMANOVA	0.046
p.adjustMANOVA	0.0852
s.dist	0.135
s.diabetes	0.0887
s.mitoG	0.101
p.diabetes	0.146
p.mitoG	0.0974

Top 20 genes
Gene	diabetes	mitoG
CAVIN1	7138	8770
SCNN1G	6471	7958
MYH9	7189	7115
MT-ND5	6025	8007
SCARB2	6376	7312
MT-ND1	5618	7323
MT-ND6	5059	8045
MT-CO1	6781	5983
CD151	6017	4815
SCNN1B	7229	4000
SCNN1A	8056	3548
B2M	5339	4978
FGA	4508	5893
FOXI1	6075	4294
NUP107	3423	7169
FAM20A	4604	5067
KCNJ10	3384	6290
MAFB	8140	2473
WT1	5237	3586
MT-CO3	2273	6269

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AGPAT2	-4051.0	-2429.0
ALG1	-2121.0	-4072.0
APOA1	3682.0	-305.0
APPL1	940.0	7089.0
B2M	5339.0	4978.0
BSCL2	4891.0	-4593.0
CAV1	875.0	7970.0
CAVIN1	7138.0	8770.0
CC2D2A	1751.0	-2392.0
CCND1	7933.0	-1628.0
CD151	6017.0	4815.0
CEP120	3471.0	2793.0
CEP290	-2988.0	5308.0
CISD2	-5462.0	6479.0
CLDN19	2681.0	-450.0
COL4A1	-1913.0	7738.0
DYNC2H1	-1831.0	-3937.0
DYNC2LI1	46.0	303.0
EIF2AK3	-6386.0	3372.0
FAM20A	4604.0	5067.0
FGA	4508.0	5893.0
FOS	827.0	3751.0
FOXI1	6075.0	4294.0
GLA	1196.0	3449.0
HIC1	1899.0	3532.0
HNF1A	7450.0	-6675.0
HNF4A	-6855.0	4619.0
HPRT1	-5564.0	8025.0
IFT140	1480.0	-4541.0
IFT172	3902.0	-5651.0
IFT80	-5454.0	-2479.0
INPP5E	6856.0	-5834.0
KCNJ10	3384.0	6290.0
KCNJ11	2961.0	-3265.0
KLF11	7284.0	1719.0
LAGE3	5065.0	1002.0
LMX1B	5720.0	823.0
MAFB	8140.0	2473.0
MEFV	-4277.0	5186.0
MMACHC	1165.0	5604.0
MT-CO1	6781.0	5983.0
MT-CO2	293.0	-1711.0
MT-CO3	2273.0	6269.0
MT-ND1	5618.0	7323.0
MT-ND4	1752.0	7883.0
MT-ND5	6025.0	8007.0
MT-ND6	5059.0	8045.0
MYH9	7189.0	7115.0
NLRP3	-5337.0	1863.0
NOD2	-6286.0	2681.0
NPHP1	705.0	5221.0
NUP107	3423.0	7169.0
NUP133	2759.0	-4113.0
OSGEP	1999.0	983.0
PAFAH1B1	-3995.0	8266.0
PAX6	-2974.0	1272.0
PPARG	-3636.0	5654.0
PRDX1	-6422.0	8698.0
PRODH	6792.5	-2080.5
RPGRIP1L	-5538.0	-2125.0
SCARB2	6376.0	7312.0
SCNN1A	8056.0	3548.0
SCNN1B	7229.0	4000.0
SCNN1G	6471.0	7958.0
SEC61A1	-6475.0	-2203.0
SLC26A4	-3154.0	-406.0
TMEM138	1311.0	-379.0
TMEM216	639.0	-5653.0
TMEM231	4190.0	-2063.0
TMEM237	-7028.0	644.0
TMEM67	-3894.0	-1057.0
TP53RK	-488.0	-6739.0
TPRKB	4020.0	-3573.0
TREX1	1252.0	2779.0
TTC21B	-657.0	-2310.0
TTR	-6090.0	3451.0
UMOD	-6036.0	-707.0
VIPAS39	-1721.0	3736.0
VPS33B	2918.5	-5911.5
WAS	-11.0	299.0
WDR19	5951.0	-1726.0
WDR34	5448.0	-6192.0
WDR4	-6102.0	-4331.0
WDR60	-383.0	-3158.0
WDR73	-2550.0	2299.0
WFS1	7688.0	-3009.0
WIPF1	-3718.0	7829.0
WT1	5237.0	3586.0
YWHAE	-2079.0	7315.0
ZNF423	-18.0	2643.0

GSE9006_TYPE_1_DIABETES_AT_DX_VS_4MONTH_POST_DX_PBMC_UP

GSE9006_TYPE_1_DIABETES_AT_DX_VS_4MONTH_POST_DX_PBMC_UP
metric	value
setSize	182
pMANOVA	0.0487
p.adjustMANOVA	0.0858
s.dist	0.105
s.diabetes	-0.00885
s.mitoG	0.105
p.diabetes	0.837
p.mitoG	0.0148

Top 20 genes
Gene	diabetes	mitoG
HNRNPA3	-6985	8827
PDIA3	-7283	7821
PDIA4	-7329	7729
HSPA5	-7309	7589
RPN1	-7121	7464
YWHAZ	-5614	8512
NSD1	-6917	6189
GMPS	-5160	8238
KDELR2	-4969	8520
ARL4A	-6095	6821
ACTR2	-5189	7356
HNRNPU	-5219	7082
P4HB	-6743	5398
NFIL3	-7012	5060
PAK2	-4906	6708
GNAI3	-3916	8277
HNRNPH2	-5391	5932
MAPRE1	-3633	8509
PTPRA	-5907	5079
CYBB	-5520	5307

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AAMP	69.0	-4287.0
ACTR2	-5189.0	7356.0
ADM	7469.0	6606.0
ADNP2	2146.0	595.0
ALDOA	6979.5	3652.5
AMDHD2	-5012.5	-6718.5
APOBR	-726.0	-1447.0
AQP9	-5382.0	1990.0
ARF6	-804.0	229.0
ARHGAP26	-7093.0	2682.0
ARL4A	-6095.0	6821.0
ATP6V0A1	936.0	1549.0
ATP6V0D1	-3890.0	3817.0
BAG5	-2637.0	8168.0
BCL6	-4525.0	36.0
BHLHE40	-185.0	1804.0
BNIP2	3400.0	6267.0
CARS2	-4415.0	-4360.0
CCDC22	-4166.0	-3221.0
CD83	-913.0	5700.0
CDC37	-682.0	-4414.0
CDK9	315.0	-5322.0
CDT1	6848.0	-4131.0
CEACAM8	3793.5	5357.5
CHFR	686.0	5588.0
CIRBP	8197.0	-922.0
CKAP4	4629.0	6520.0
COPG1	-3891.0	3599.0
COPS7B	-2394.0	-5916.0
COTL1	8183.0	-5409.0
CREM	-3568.0	7564.0
CTSD	5035.5	6716.5
CTSZ	-2861.0	2478.0
CXCR4	4516.0	7547.0
CYBB	-5520.0	5307.0
DDIT4	5684.0	4879.0
DDX3X	3775.0	8058.0
DHCR7	3894.0	-5672.0
DUSP1	-2905.0	-1666.0
DUSP5	4923.0	4971.0
EGR3	-3140.0	2625.0
EHD4	5130.0	8802.0
EIF4ENIF1	-1402.0	4499.0
ELMO1	-4833.0	4917.0
FOSB	6048.0	-74.0
FZR1	3996.0	-5000.0
G0S2	4904.0	8051.0
G3BP2	-4462.0	5928.0
GLG1	-3103.0	2134.0
GLUD1	8064.5	3730.5
GLUL	7900.0	3064.0
GMPS	-5160.0	8238.0
GNAI3	-3916.0	8277.0
GPAA1	696.0	-5319.0
GPI	4816.0	5422.0
GSN	7535.0	7997.0
GUSB	-7203.0	1338.0
HBEGF	-6694.0	-80.0
HERPUD1	924.0	3108.0
HMGB2	6857.0	1304.0
HNRNPA1	7891.0	-6290.0
HNRNPA3	-6985.0	8827.0
HNRNPH2	-5391.0	5932.0
HNRNPK	-808.0	7246.0
HNRNPU	-5219.0	7082.0
HP	-1369.5	6104.5
HSPA5	-7309.0	7589.0
HSPA9	-566.0	8181.0
HYOU1	-7255.0	4009.0
IBTK	-3540.0	7124.0
ID1	3953.0	-1529.0
IER2	6951.0	-524.0
IL1B	-6242.0	3978.0
IL1R1	3443.0	7288.0
ILVBL	3004.0	-6442.0
IVNS1ABP	7265.0	1321.0
JUNB	4544.0	2430.0
JUND	4819.0	-5317.0
KDELR2	-4969.0	8520.0
KIAA0930	4163.0	-2258.0
LAPTM5	-5721.0	4643.0
LSM12	-2869.0	4929.0
MAFB	8140.0	2473.0
MAPK1IP1L	345.0	-2618.0
MAPRE1	-3633.0	8509.0
MARCKS	-1781.0	5038.0
MCL1	6260.0	-1020.0
MFSD10	6323.0	-5202.0
MGAM	561.0	417.0
MINK1	-4877.0	-2450.0
MRPL12	-2913.0	4144.0
NADSYN1	6875.0	-6478.0
NAMPT	8078.0	8082.0
NDUFV1	4313.0	-2431.0
NECAP1	-79.0	5214.0
NFIL3	-7012.0	5060.0
NFKB2	2120.0	-4751.0
NFKBIA	1631.0	4830.0
NOC2L	-4670.0	1010.0
NPTN	2459.0	6839.0
NR4A2	-168.0	5972.0
NSD1	-6917.0	6189.0
NUDT18	1357.0	-3593.0
NUP93	5331.0	6196.0
ODF2	8196.0	-5679.0
P2RY2	7810.0	1570.0
P4HB	-6743.0	5398.0
PABPC4	2846.0	-3784.0
PAF1	799.0	4723.0
PAK2	-4906.0	6708.0
PDIA3	-7283.0	7821.0
PDIA4	-7329.0	7729.0
PFKFB3	7737.0	7129.0
PHF21A	-2368.0	829.0
PIGA	5537.0	-3293.0
PLEKHO2	-1522.5	7084.5
PLK3	4741.0	6581.0
PPIF	6302.0	-1305.0
PPP1R15A	7471.0	4761.0
PPP4C	851.0	-5414.0
PRCC	-3064.0	-3244.0
PRMT7	5794.0	1791.0
PRPF6	3568.0	279.0
PSMD13	1898.0	5044.0
PTPRA	-5907.0	5079.0
PTX3	-4488.0	-2545.0
PUF60	-754.0	731.0
QSOX1	7456.0	1100.0
RAB1B	-80.0	-4574.0
RAB8A	-855.0	2596.0
RBM3	8175.0	5192.0
RETREG2	-3830.0	-5500.0
REX1BD	1924.0	-3848.0
RGS1	-2963.0	3569.0
RNF19B	-3119.0	-1959.0
RPN1	-7121.0	7464.0
RRP12	3149.0	2306.0
RTN3	-2760.0	5623.0
SAFB	-1933.0	-1132.0
SAFB2	3321.0	-6673.0
SART1	2632.0	-1920.0
SAT1	5606.0	7029.0
SCO2	-3687.0	2948.0
SCPEP1	4057.0	1287.0
SFN	3916.0	5704.0
SFPQ	-5196.0	-4828.0
SGK1	4488.0	7322.0
SGTA	1239.0	-1672.0
SIK1	3616.5	666.5
SIL1	-5762.0	4185.0
SLC30A9	2912.0	4119.0
SNF8	2397.0	-3270.0
SOCS1	-253.0	-5520.0
SOCS3	4231.0	7185.0
SPATA2L	2799.0	-4361.0
SRSF9	-2009.0	-5029.0
STX11	608.0	-2244.0
TCIRG1	-5363.0	-3931.0
TESK2	2566.0	-4280.0
THOC6	-3723.0	-3958.0
TNFAIP3	-151.0	2986.0
TNFRSF14	872.0	-1648.0
TP53BP2	6638.0	5316.0
TPD52L2	95.0	3488.0
TREM1	169.0	-2242.0
TRIB1	7573.0	2586.0
TSC22D3	1663.0	5520.0
TSPAN14	-6627.0	1158.0
TSR3	4228.0	-5856.0
TYMP	5612.0	-6441.0
UAP1	-7245.0	1255.0
UPP1	5774.0	8231.0
UQCRC1	5627.0	1729.0
VASP	-2568.0	4503.0
WDR18	-5000.0	-3150.0
WDR70	-2702.0	2639.0
WIPI2	-3357.0	-5676.0
YWHAZ	-5614.0	8512.0
ZBTB17	2405.0	-590.0
ZFP36	-1295.0	1383.0
ZFP36L1	-5993.0	4405.0
ZNF394	73.0	-278.0

HP_MATERNAL_DIABETES

HP_MATERNAL_DIABETES
metric	value
setSize	21
pMANOVA	0.0543
p.adjustMANOVA	0.0913
s.dist	0.291
s.diabetes	-0.0316
s.mitoG	-0.289
p.diabetes	0.802
p.mitoG	0.0218

Top 20 genes
Gene	diabetes	mitoG
SUFU	-4804	-5489
SHH	-4143	-5003
GJA1	-2103	-4151
DLL1	-4076	-1816
PROKR2	-2068	-3287
FUZ	-928	-5631

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ARNT2	8205.0	310.0
CDON	-5264.0	357.0
CLCNKB	8258.5	-2053.5
DISP1	1277.0	-673.0
DLL1	-4076.0	-1816.0
ERGIC1	-6556.0	5268.0
FGFR1	6753.0	-812.0
FUZ	-928.0	-5631.0
GAS1	7552.0	-2009.0
GJA1	-2103.0	-4151.0
GLI2	-1482.0	794.0
HESX1	5292.0	-1586.0
KCNJ11	2961.0	-3265.0
PPARG	-3636.0	5654.0
PROKR2	-2068.0	-3287.0
PTCH1	2844.0	-1386.0
SHH	-4143.0	-5003.0
SLC12A3	6051.0	-4654.0
SUFU	-4804.0	-5489.0
TGIF1	-4370.0	895.0
VANGL1	-5326.0	2768.0

KEGG_TYPE_I_DIABETES_MELLITUS

KEGG_TYPE_I_DIABETES_MELLITUS
metric	value
setSize	25
pMANOVA	0.069
p.adjustMANOVA	0.109
s.dist	0.256
s.diabetes	-0.255
s.mitoG	-0.0245
p.diabetes	0.0274
p.mitoG	0.832

Top 20 genes
Gene	diabetes	mitoG
HLA-DOB	-4577.0	-4767.0
HLA-DMB	-1643.5	-3831.5
PTPRN	-1366.0	-4132.0
PRF1	-1422.0	-684.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
CD28	-4408.0	5134.0
CD80	-3453.0	3286.0
CD86	-2679.0	5554.0
CPE	-7351.0	8370.0
FAS	3093.0	7580.0
FASLG	834.0	4880.0
GAD1	-2488.0	2186.0
GZMB	270.0	-2421.0
HLA-DMA	275.0	-5969.0
HLA-DMB	-1643.5	-3831.5
HLA-DOA	-5599.0	3997.0
HLA-DOB	-4577.0	-4767.0
HLA-DQB1	-4730.5	1217.5
HLA-DRB1	1762.5	-4711.5
HLA-DRB5	1762.5	-4711.5
HLA-E	3698.5	-6121.5
HLA-G	3698.5	-6121.5
HSPD1	-7211.0	3739.0
ICA1	-2242.0	7076.0
IL1A	-1142.0	1688.0
IL1B	-6242.0	3978.0
PRF1	-1422.0	-684.0
PTPRN	-1366.0	-4132.0
PTPRN2	5657.0	877.0
TNF	-2778.0	4883.0

GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_DN

GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_DN
metric	value
setSize	165
pMANOVA	0.0705
p.adjustMANOVA	0.109
s.dist	0.0925
s.diabetes	0.0584
s.mitoG	0.0718
p.diabetes	0.196
p.mitoG	0.112

Top 20 genes
Gene	diabetes	mitoG
CP	7736	7894
ATP2B4	7691	7255
S100A10	7779	5985
OSBPL1A	6468	6678
RGS5	5300	8040
GSTO1	8023	4922
TIMM8A	4496	7741
LUM	4367	7749
RUFY2	6866	4915
ADAMTS5	4732	6838
SMAD1	5880	5459
RPL19	4654	6782
BMPR1B	5157	5691
GMFG	3969	7186
MYL9	3189	8125
RO60	3028	8186
LPP	7785	3122
IFT46	5958	4026
NOD1	5283	4068
PFDN5	2482	8089

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCC10	6808.0	-6598.0
ABITRAM	-1517.0	6842.0
ADAMTS5	4732.0	6838.0
ADGRA2	6742.0	-4913.0
ANXA2	-337.0	8406.0
APOO	-605.0	8803.0
ARMCX4	-5810.0	6643.0
ARMH3	7270.0	-3703.0
ASRGL1	8192.0	1093.0
ATAT1	-6757.0	-6199.0
ATP2B4	7691.0	7255.0
ATP5F1C	164.0	8242.0
ATXN3L	633.5	4150.5
BACE1	1099.0	3140.0
BMPR1B	5157.0	5691.0
BRD3	-2862.0	-3037.0
C1orf54	498.0	-619.0
C2orf68	-4445.0	-3173.0
C3orf18	7780.0	-4538.0
CASR	-5215.0	-1382.0
CBFA2T2	1753.0	5677.0
CCDC51	3605.0	-4365.0
CCDC71	-4071.0	5182.0
CCNF	4264.0	-2470.0
CCNI	265.0	6150.0
CCNT1	-709.0	6941.0
CCSER2	-6272.0	3686.0
CDKN2C	6608.0	-3067.0
CLEC1A	1450.0	6546.0
CLOCK	-7043.0	8412.0
COA4	-3012.0	3241.0
COMMD3	-4289.0	8822.0
COQ6	1950.0	-3453.0
COX4I1	6324.0	-2473.0
CP	7736.0	7894.0
CXorf56	-5589.0	5814.0
DAB2	-5689.0	1606.0
DARS2	-5166.0	329.0
DCTN2	2623.0	-2017.0
DNAJC1	-6576.0	4427.0
DNAJC28	3205.0	1021.0
DPM3	-20.0	-5789.0
DST	1303.0	1938.0
EIF2S2	-3307.0	8799.0
EIF5	-1683.0	7276.0
EIF5B	-1780.0	8616.0
EPS15L1	3879.0	-4887.0
ESRP2	5000.0	-3533.0
F2	-3087.0	4699.0
FABP1	289.0	-1810.0
FAM111A	-3910.0	3549.0
FIG4	-2261.0	2661.0
GFER	-6332.0	3685.0
GFOD2	714.0	-3471.0
GLRA3	5145.0	-5574.0
GMFG	3969.0	7186.0
GPR171	-4112.0	6669.0
GRIA1	3840.0	-983.0
GSTO1	8023.0	4922.0
GUCY1A1	1918.0	7519.0
GUCY1B1	-1671.0	7666.0
HINT1	3946.0	413.0
HOXA9	3263.0	751.0
HSPA1L	-3778.0	-133.0
HSPB7	5741.0	-1096.0
IER3IP1	-246.5	-3466.5
IFT46	5958.0	4026.0
IGBP1	-1717.5	4157.5
ING4	-4464.0	-4099.0
ITGB5	7359.0	1316.0
KCNMA1	7158.0	-4954.0
KCNMB1	2084.0	6965.0
KCNN3	244.0	-1001.0
KLF7	-4593.0	8044.0
LAMTOR5	4258.0	4393.0
LIPE	2527.0	415.0
LPP	7785.0	3122.0
LRRC75B	-548.0	-2539.0
LUM	4367.0	7749.0
MAP3K19	380.0	543.0
MC2R	2425.0	5288.0
MCCC1	-5695.0	1708.0
MDH1	4402.0	4491.0
METTL9	-553.0	7370.0
MPV17	-5777.0	4042.0
MTHFD2L	5275.0	1578.0
MYL9	3189.0	8125.0
NOD1	5283.0	4068.0
NRCAM	3619.0	5428.0
OSBPL1A	6468.0	6678.0
OXA1L	4609.0	-4940.0
PAFAH1B2	-1657.0	7964.0
PBLD	2456.0	-2483.0
PCSK2	-329.0	-3823.0
PDPK1	-4074.0	1936.0
PFDN5	2482.0	8089.0
PHF11	-7148.0	3818.0
PIPOX	-966.0	1121.0
PNPLA2	7942.0	833.0
POLH	-295.0	1887.0
PRELID3A	496.0	-5362.0
PRRG4	-1441.0	5729.0
PTCRA	4212.0	-5168.0
RABEPK	2166.0	960.0
RALGPS1	2494.0	-5324.0
RBMS1	-4349.0	7009.0
RBMX2	4443.0	3927.0
RCAN2	1791.0	4781.0
RGS5	5300.0	8040.0
RHOBTB1	-7181.0	-4585.0
RNF113A	-3023.0	3421.0
RO60	3028.0	8186.0
RPGR	815.0	-1281.0
RPL12	6107.0	-5604.0
RPL14	5110.0	-1875.0
RPL19	4654.0	6782.0
RTRAF	-2127.0	8772.0
RUFY2	6866.0	4915.0
RUFY3	5428.0	-5971.0
S100A10	7779.0	5985.0
SCNM1	5490.0	-5900.0
SELP	5864.0	2861.0
SEMA6A	-6678.0	6683.0
SEMA6C	6649.0	-2213.0
SERF2	-2395.0	-2526.0
SFSWAP	5753.0	-6334.0
SLC12A5	1728.0	-2402.0
SLC14A2	5801.0	-6223.0
SLC18A1	-1729.0	-3428.0
SLC25A14	-1689.0	-3486.0
SLC35E2B	1081.0	797.0
SLC38A7	-3658.0	-5269.0
SLC4A5	6363.0	612.0
SLC66A1	-1315.0	-5738.0
SMAD1	5880.0	5459.0
SOX13	7723.0	-5757.0
SUGP2	-4111.0	-2000.0
SUOX	6862.0	-1063.0
TCF15	-162.0	2805.0
TCTN1	4752.0	-6685.0
TFG	-5471.0	5860.0
TGFB3	-1546.0	8322.0
TIMM8A	4496.0	7741.0
TIMM8B	-1186.0	7371.0
TIMM9	-6212.0	1407.0
TM6SF2	8051.0	1210.0
TMEM104	-119.0	-4147.0
TMEM223	-3617.0	5440.0
TMEM254	-7257.0	-5697.0
TNPO2	2302.0	-5963.0
TNPO3	-3142.0	2781.0
TPCN1	5971.0	-6632.0
TRADD	-1318.0	-2687.0
TRIM2	-1014.5	6967.5
TRIM62	6914.0	-31.0
TTC1	-896.0	7387.0
TTF1	-4501.0	-2293.0
TUG1	-3603.0	5016.0
TULP3	-6456.0	-4812.0
USP13	-642.0	3525.0
VCL	-4796.0	7947.0
YIPF6	-4393.0	6442.0
ZBTB40	-7017.0	-4622.0
ZNF609	5163.0	-835.0
ZNF629	7746.0	563.0

HP_TYPE_II_DIABETES_MELLITUS

HP_TYPE_II_DIABETES_MELLITUS
metric	value
setSize	139
pMANOVA	0.0792
p.adjustMANOVA	0.117
s.dist	0.12
s.diabetes	0.104
s.mitoG	-0.059
p.diabetes	0.0342
p.mitoG	0.231

Top 20 genes
Gene	diabetes	mitoG
HNF1A	7450.0	-6675.0
SPINK1	7315.0	-6310.0
PCNT	7772.0	-5691.0
IRS1	7064.0	-5549.0
ZNF513	5138.0	-5859.0
SEMA4A	4531.0	-6239.0
SLC12A3	6051.0	-4654.0
WFS1	7688.0	-3009.0
IFT172	3902.0	-5651.0
USH2A	4128.0	-4852.0
MKRN3	3610.0	-5497.0
LMNA	5092.0	-3667.0
CERKL	2847.0	-6517.0
PEX10	4740.0	-3790.0
CRX	3115.0	-5642.0
CLCNKB	8258.5	-2053.5
ELN	3735.0	-4141.0
ATM	5701.0	-2536.0
BBS2	4288.0	-2928.0
AGBL5	1997.0	-5951.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCA4	277.0	-4736.0
AGBL5	1997.0	-5951.0
AHI1	5934.0	682.0
AHR	2185.5	5110.5
AIP	-549.0	3479.0
AKT2	-4939.0	3281.0
ALMS1	1616.0	-638.0
AMACR	-7290.0	-2238.0
AR	2841.0	2349.0
ARHGEF18	5858.5	-119.5
ARL2BP	6697.0	5530.0
ARL3	4427.0	1315.0
ARL6	-1042.0	6323.0
ATM	5701.0	-2536.0
BAZ1B	-6161.0	79.0
BBS2	4288.0	-2928.0
BEST1	-4777.0	1784.0
BLM	6861.0	5650.0
BRAF	-6284.0	4955.0
C8orf37	-2986.0	5151.0
CA4	-6448.0	2608.0
CAT	-602.0	4907.0
CEP19	-4989.0	5512.0
CERKL	2847.0	-6517.0
CLCNKB	8258.5	-2053.5
CLIP2	-4217.0	-5731.0
CLRN1	3080.0	-2656.0
CNGB1	-1532.0	170.0
CRB1	-4803.0	-4998.0
CRX	3115.0	-5642.0
CTNNB1	-6022.0	2664.0
DHDDS	-4632.0	-1973.0
DHX38	3912.0	-1919.0
DMXL2	5807.0	1760.0
ELN	3735.0	-4141.0
ENPP1	-4115.0	6101.0
FAM161A	7876.0	-973.0
FBN1	6578.0	8391.0
FSCN2	3414.0	-1787.0
GLRX5	6724.0	4490.0
GPD2	-5845.0	8339.0
GTF2I	-3516.0	-4858.0
GTF2IRD1	3674.0	2580.0
GUCA1B	-1248.0	-1221.0
HERC2	-123.0	-4460.0
HGSNAT	6373.0	2744.0
HMGA1	7803.0	-1488.0
HNF1A	7450.0	-6675.0
HNF1B	-1771.0	-6141.0
HNF4A	-6855.0	4619.0
IDH3A	-958.0	7080.0
IDH3B	3081.0	573.0
IFT140	1480.0	-4541.0
IFT172	3902.0	-5651.0
IFT88	-4968.0	4229.0
IGF2BP2	1777.0	3236.0
IMPDH1	1190.0	4821.0
IMPG2	226.0	-3197.0
INSR	3417.0	173.0
IRS1	7064.0	-5549.0
IRS2	-582.0	3045.0
KCNJ11	2961.0	-3265.0
KIAA1549	2144.0	-3229.0
KIZ	1104.0	4332.0
KLF11	7284.0	1719.0
KLHL7	68.0	5321.0
LIG4	-3349.0	7573.0
LIMK1	3519.0	2264.0
LMNA	5092.0	-3667.0
LRAT	-1726.0	2615.0
MAK	-946.0	-2629.0
MAPK8IP1	7092.0	379.0
MEN1	-1596.0	-513.0
MERTK	2880.0	6387.0
MKRN3	3610.0	-5497.0
MT-CO1	6781.0	5983.0
MT-CO2	293.0	-1711.0
MT-CO3	2273.0	6269.0
MT-ND1	5618.0	7323.0
MT-ND4	1752.0	7883.0
MT-ND5	6025.0	8007.0
MT-ND6	5059.0	8045.0
NDN	894.0	5072.0
NEK2	2754.0	-2383.0
NRL	-2049.0	-4885.0
OFD1	5855.0	5805.0
PCNT	7772.0	-5691.0
PDE6A	-7253.0	-877.0
PDE6B	1821.0	-4534.0
PDE6G	1178.0	-3727.0
PEX10	4740.0	-3790.0
PLCD1	5021.0	2747.0
PNPLA6	-3845.0	-5609.0
POLA1	-4288.0	598.0
POLR3A	5281.0	-1328.0
POMGNT1	-1550.0	1400.0
PPARG	-3636.0	5654.0
PRCD	476.0	-2411.0
PROM1	4188.0	1239.0
PRPF3	-4119.0	5240.0
PRPF31	-387.0	4117.0
PRPF4	-4040.0	1952.0
PRPF6	3568.0	279.0
PRPF8	947.0	5393.0
PTPN1	6946.0	3039.0
RDH12	-3849.0	788.0
REEP6	8248.0	6316.0
RETN	-1704.0	-1106.0
RFC2	-2310.0	1686.0
RHO	1583.0	-5941.0
ROM1	1249.0	206.0
RP1	-5651.0	2024.0
RP2	-6219.0	5609.0
RP9	3230.0	-898.0
RPGR	815.0	-1281.0
SAG	-299.0	-4455.0
SCAPER	6106.0	3001.0
SEMA4A	4531.0	-6239.0
SLC12A3	6051.0	-4654.0
SLC2A2	7902.0	2301.0
SLC30A8	3357.0	-1419.0
SLC7A14	-129.0	-4517.0
SNRNP200	-4151.0	749.0
SNRPN	-4895.0	6816.0
SPATA7	3517.0	1166.0
SPINK1	7315.0	-6310.0
STUB1	4177.0	-2823.0
TBL2	-4096.0	539.0
TCF7L2	-4057.0	-2326.0
TOPORS	4771.0	6078.0
TTC8	-3401.0	-592.0
TUB	1106.0	-1287.0
TULP1	3418.0	3237.0
USH2A	4128.0	-4852.0
WFS1	7688.0	-3009.0
WRN	1837.0	6937.0
XRCC4	-4715.0	7026.0
ZNF408	4726.0	-545.0
ZNF513	5138.0	-5859.0

GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP

GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP
metric	value
setSize	169
pMANOVA	0.103
p.adjustMANOVA	0.146
s.dist	0.104
s.diabetes	-0.0849
s.mitoG	0.0603
p.diabetes	0.0573
p.mitoG	0.177

Top 20 genes
Gene	diabetes	mitoG
CHPT1	-6923	8136
PSIP1	-6597	7229
CLCN4	-6858	6649
TRIM44	-6012	7523
RASA1	-5274	8011
MACF1	-5316	7849
KANSL1L	-7157	5803
SLA	-5684	7023
MSL2	-6222	6310
FLT1	-4346	8420
ZNRF2	-7152	5062
PUM2	-6583	5351
TLK1	-4064	8347
DTX4	-6400	5051
SEMA3D	-4476	7110
CHIC1	-6180	5139
BRAF	-6284	4955
KDM1B	-5262	5818
VEZF1	-3497	8422
CYBB	-5520	5307

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCC5	4476.0	-5612.0
ABL2	-4140.0	5490.0
ADAM28	-400.0	-2844.0
AGBL2	843.0	-1917.0
AIDA	3668.0	8141.0
AMPD3	7453.0	2602.0
ANKRD44	4522.0	3975.0
AP4S1	2217.0	1812.0
APLP2	6384.0	6357.0
ATAD2B	-6031.0	4819.0
ATP6V1H	-1095.0	8501.0
BACH2	-1914.0	-2696.0
BMP2K	3031.0	4459.0
BRAF	-6284.0	4955.0
CAMK1D	-4392.0	3073.0
CCDC130	2887.0	2873.0
CCNY	1460.0	6289.0
CD1D	5611.0	119.0
CD79B	-2701.0	2433.0
CDK5R1	4903.0	-6336.0
CDKL1	-4030.0	-2983.0
CELF1	-3196.0	4473.0
CHD7	6375.0	5995.0
CHIC1	-6180.0	5139.0
CHL1	-6480.0	-3081.0
CHPT1	-6923.0	8136.0
CLCF1	6318.0	-5706.0
CLCN4	-6858.0	6649.0
COLGALT1	6399.0	362.0
CRIP3	-302.0	-4109.0
CTNND1	5833.0	1565.0
CYBB	-5520.0	5307.0
CYP2U1	4939.0	30.0
DDX39B	4289.0	-5871.0
DEAF1	7709.0	-5938.0
DENND4C	-5667.0	856.0
DISP1	1277.0	-673.0
DOCK11	-5090.0	5477.0
DOCK2	-5657.0	5085.0
DTX1	-4241.0	-1078.0
DTX4	-6400.0	5051.0
DZIP3	-3939.0	-4126.0
ENPP1	-4115.0	6101.0
EPG5	4477.0	-3271.0
ESD	771.0	8516.0
ETS1	-599.0	8648.0
EVL	-186.0	264.0
EXOC2	7117.0	-1912.0
FBXO11	-2703.0	8171.0
FCHSD2	-4459.0	4958.0
FCMR	908.0	2646.0
FCRLA	-3221.0	4407.0
FLT1	-4346.0	8420.0
FMNL3	4975.0	5690.0
GALNT7	-5139.0	1034.0
GSAP	-7019.0	-4275.0
HNRNPA1	7891.0	-6290.0
IFNGR2	4633.0	5019.0
IL4R	647.0	5708.0
INPP5D	-1230.0	5535.0
JADE2	7429.0	-5745.0
JAK3	7556.0	-6301.0
KANSL1L	-7157.0	5803.0
KCNG1	-4013.0	-2822.0
KDM1B	-5262.0	5818.0
KHDRBS2	-5128.0	-5318.0
KLF16	6650.0	-5119.0
KLHL36	2189.0	-5945.0
KMT5B	-2983.0	-2250.0
LARS1	7823.0	-1599.0
LAT2	-2578.0	2305.0
LIPA	5735.0	-3962.0
LPGAT1	-6932.0	-124.0
LRRC56	2735.0	-5366.0
MACF1	-5316.0	7849.0
MID1IP1	-3383.0	5984.0
MSL2	-6222.0	6310.0
NR3C2	7008.0	-3900.0
NSD3	-2348.0	-5726.0
NUDCD3	4876.0	-1297.0
NUMA1	461.0	-2761.0
OBI1	-2332.0	4483.0
OGA	-3220.0	3703.0
OSTF1	6553.0	5854.0
PARP12	3615.0	-4394.0
PARP14	-5054.0	4222.0
PCNX2	17.0	2589.0
PCSK7	-3212.0	-1627.0
PDE8A	-3329.0	7592.0
PHKA2	5251.0	-5498.0
PIK3C2B	6591.0	344.0
PLEKHF2	-5672.0	4690.0
PLSCR1	-6591.0	-6700.0
POLM	7521.0	-6490.0
PSIP1	-6597.0	7229.0
PTGS1	5729.0	6228.0
PTPN6	-1098.0	2140.0
PUM1	-856.0	-3002.0
PUM2	-6583.0	5351.0
RAB11FIP1	6379.0	-3314.0
RAB12	-1057.0	8176.0
RABGAP1	-2389.0	6981.0
RALGPS2	-7239.0	156.0
RASA1	-5274.0	8011.0
RASGRP2	-326.0	-409.0
RB1	7982.0	7013.0
RBM6	-4932.0	-3441.0
RIPOR1	7727.0	791.0
RNASEH2B	-3460.0	1126.0
RNF130	-2655.0	5163.0
RNF216	-840.0	5584.0
RTN4IP1	-2805.0	-1723.0
SAYSD1	-1415.0	-4296.0
SCARNA6	7608.0	-6503.0
SELENON	4701.5	6928.5
SEMA3D	-4476.0	7110.0
SENP7	-4130.0	-2819.0
SESN3	7805.0	5009.0
SGSM3	1120.0	-6412.0
SHPRH	-931.0	1674.0
SIPA1L1	-7292.0	-118.0
SLA	-5684.0	7023.0
SLC2A1	6575.0	1160.0
SLC30A4	-608.0	7397.0
SLC38A11	2988.0	-3028.0
SMC6	2636.0	7994.0
SMG1	-4496.0	2722.0
SNORA14B	-2282.5	1679.5
SNRK	5854.0	6577.0
SNX10	-183.0	2964.0
SNX27	-6914.0	-508.0
SORL1	6003.0	-3663.0
SP4	7612.0	4668.0
ST3GAL1	3065.0	8669.0
ST3GAL3	-3090.0	3648.0
STAT5A	2714.0	-3795.0
SUSD6	2969.0	-594.0
SWAP70	1447.0	-519.0
TANGO6	-944.0	-6105.0
TBC1D10A	-3577.0	-5886.0
THADA	-2726.0	-5996.0
TLK1	-4064.0	8347.0
TMED8	-4216.0	1979.0
TRAK2	6380.0	7944.0
TRIM44	-6012.0	7523.0
TRMT2B	-4410.0	3976.0
TSC22D3	1663.0	5520.0
TSPAN33	657.0	-4997.0
TTC13	-5468.0	1837.0
TTC21A	4485.0	252.0
TTC32	-2659.0	-209.0
UBE2E2	2753.0	4580.0
USF3	-3481.0	3621.0
USP44	-3242.0	2971.0
UTP25	-910.0	-3889.0
VEZF1	-3497.0	8422.0
VPS13C	8167.0	-1191.0
WDR5B	-3983.0	2770.0
ZBTB10	2823.0	4913.0
ZC3HAV1	-469.0	-613.0
ZDHHC2	-5398.0	353.0
ZDHHC23	484.0	-3279.0
ZFYVE19	1682.0	4070.0
ZFYVE27	5795.0	-6615.0
ZNF358	2745.0	-1521.0
ZNF557	1572.5	821.5
ZNF678	-1409.5	8810.5
ZNRF2	-7152.0	5062.0
ZSCAN29	-5275.0	3348.0

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_1MONTH_POST_DX_DN

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_1MONTH_POST_DX_DN
metric	value
setSize	153
pMANOVA	0.217
p.adjustMANOVA	0.297
s.dist	0.0896
s.diabetes	0.0517
s.mitoG	-0.0732
p.diabetes	0.271
p.mitoG	0.119

Top 20 genes
Gene	diabetes	mitoG
ERF	8190	-6273
ABCC10	6808	-6598
KLHL26	6872	-6028
PLCG1	8067	-4962
INPP5E	6856	-5834
ANKZF1	5848	-6670
KCNMA1	7158	-4954
C3orf18	7780	-4538
ADGRA2	6742	-4913
RUFY3	5428	-5971
TCTN1	4752	-6685
PCBP4	5524	-5626
TAZ	4420	-6361
CLASRP	4106	-6614
NFIC	5421	-4653
NOL6	7943	-3108
SKP2	5738	-4232
JAKMIP2	3767	-6132
EPOR	7888	-2666
CDKN2C	6608	-3067

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCC10	6808.0	-6598.0
ACTN2	-160.0	4310.0
ADGRA2	6742.0	-4913.0
ADSL	2344.0	-1198.0
ALX1	-683.0	-381.0
ANKZF1	5848.0	-6670.0
AQP6	5108.0	-1644.0
ATAT1	-6757.0	-6199.0
ATXN3L	633.5	4150.5
B4GALT4	6095.0	4039.0
B4GALT7	1147.0	-2488.0
BACE1	1099.0	3140.0
BICD1	-2065.0	6371.0
BOLA1	2756.0	-4124.0
C11orf24	1434.0	3904.0
C3orf18	7780.0	-4538.0
CASR	-5215.0	-1382.0
CBFA2T2	1753.0	5677.0
CBY1	-5032.0	4324.0
CCDC51	3605.0	-4365.0
CCDC93	-1710.0	-439.0
CCR1	-3507.0	4981.0
CCR7	-4606.0	-4191.0
CD248	537.0	1642.0
CD82	7938.0	1042.0
CDKN2C	6608.0	-3067.0
CENPI	-1339.0	-6050.0
CHTOP	-4615.0	-1316.0
CIITA	-5946.0	-2698.0
CLASRP	4106.0	-6614.0
CNTNAP1	2965.0	-4300.0
COA4	-3012.0	3241.0
CPN2	-1570.0	-3447.0
CSRNP2	6469.0	1246.0
CXCL13	-1107.0	4180.0
CYP4F12	7297.5	2796.5
CYREN	-3549.0	-2232.0
DARS2	-5166.0	329.0
DDX6	-4502.0	5780.0
DHX32	-759.0	5873.0
DIS3	-6175.0	6931.0
DNAJC28	3205.0	1021.0
DNMBP	4678.0	6019.0
DST	1303.0	1938.0
EEF2KMT	4275.0	-1189.0
EGR2	-1617.0	4130.0
EGR3	-3140.0	2625.0
EIF5B	-1780.0	8616.0
EPOR	7888.0	-2666.0
ERF	8190.0	-6273.0
EXD2	-471.0	839.0
F2	-3087.0	4699.0
FABP1	289.0	-1810.0
FAM111A	-3910.0	3549.0
FAM155B	-6604.0	550.0
FAM171A1	-6511.0	-1380.0
FGA	4508.0	5893.0
GFOD2	714.0	-3471.0
GIMAP5	-4554.5	7057.5
GMFG	3969.0	7186.0
GTF3C2	1131.0	-6296.0
GULP1	3722.0	7458.0
HDAC7	5870.0	-2839.0
HIVEP2	-4281.0	6509.0
HMBS	2651.0	6449.0
HSPA1L	-3778.0	-133.0
HSPB7	5741.0	-1096.0
IL11	-3409.0	1307.0
IL16	-238.0	5474.0
ING4	-4464.0	-4099.0
INPP5E	6856.0	-5834.0
JAKMIP2	3767.0	-6132.0
KCNMA1	7158.0	-4954.0
KEL	1962.0	-4981.0
KLF7	-4593.0	8044.0
KLHL22	-810.5	-5052.5
KLHL26	6872.0	-6028.0
KPTN	3882.0	-3219.0
LBHD1	-5908.0	7848.0
LIPE	2527.0	415.0
LRRC75B	-548.0	-2539.0
LRRC8E	3102.0	-2604.0
MAP3K19	380.0	543.0
MAP3K20	8060.0	6853.0
MLYCD	-6254.0	-1293.0
MRPL17	-3013.0	6746.0
MTHFS	179.5	-3965.5
MUS81	5269.0	-2722.0
NCKAP1L	-1592.0	4630.0
NFIC	5421.0	-4653.0
NOL6	7943.0	-3108.0
NOMO3	-3756.0	-1252.0
NOP10	2308.0	5890.0
PCBP4	5524.0	-5626.0
PCDH7	7022.0	-805.0
PCSK2	-329.0	-3823.0
PDPK1	-4074.0	1936.0
PEX5L	2843.0	-306.0
PIP5K1A	-1663.0	5148.0
PLCG1	8067.0	-4962.0
PLEKHA1	4350.0	-2221.0
PRELID3A	496.0	-5362.0
PRSS53	-876.0	453.0
PUS3	-4535.0	6560.0
RABEPK	2166.0	960.0
RABIF	-2521.0	-1135.0
RALGPS1	2494.0	-5324.0
RBMX2	4443.0	3927.0
REXO2	-5252.0	7861.0
RGS5	5300.0	8040.0
RNF113A	-3023.0	3421.0
RNF167	-1219.0	-3078.0
RNF25	-27.0	1761.0
ROBO3	-5418.0	-1877.0
RPGR	815.0	-1281.0
RPS16	6244.0	1119.0
RTP4	-2887.0	3910.0
RUFY3	5428.0	-5971.0
RXRA	-5143.0	1552.0
SEMA6C	6649.0	-2213.0
SEPTIN9	4938.0	-235.0
SH2D3C	6944.0	958.0
SKP2	5738.0	-4232.0
SLC12A5	1728.0	-2402.0
SLC19A1	4798.0	-4123.0
SLC39A1	3529.0	1673.0
SNX19	15.0	855.0
SPSB1	7434.0	4252.0
SRPK2	5994.0	1036.0
SUOX	6862.0	-1063.0
TAZ	4420.0	-6361.0
TCTN1	4752.0	-6685.0
TEK	-2265.0	8575.0
TFG	-5471.0	5860.0
TGFB3	-1546.0	8322.0
TIMM8A	4496.0	7741.0
TIMM8B	-1186.0	7371.0
TMEM104	-119.0	-4147.0
TMEM223	-3617.0	5440.0
TRAF3	-6416.0	5442.0
TRIM2	-1014.5	6967.5
TRIM62	6914.0	-31.0
TSPAN32	1.0	-162.0
UBAP1	-6158.0	7653.0
VPS52	-3308.0	-5643.0
WDR5B	-3983.0	2770.0
WFDC1	-2408.0	3727.0
YIF1B	5058.0	-3729.0
ZBTB40	-7017.0	-4622.0
ZNF629	7746.0	563.0
ZNF654	-1490.0	8187.0
ZNF692	-813.0	-6529.0
ZNF778	743.5	3019.5

HP_NEONATAL_INSULIN_DEPENDENT_DIABETES_MELLITUS

HP_NEONATAL_INSULIN_DEPENDENT_DIABETES_MELLITUS
metric	value
setSize	10
pMANOVA	0.338
p.adjustMANOVA	0.447
s.dist	0.239
s.diabetes	0.166
s.mitoG	0.172
p.diabetes	0.364
p.mitoG	0.347

Top 20 genes
Gene	diabetes	mitoG
STAT3	8126	4982
PLAGL1	6416	5973
KLF11	7284	1719
APPL1	940	7089

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
APPL1	940	7089
EIF2AK3	-6386	3372
GATA6	-1651	6694
HNF1A	7450	-6675
HNF4A	-6855	4619
KCNJ11	2961	-3265
KLF11	7284	1719
PLAGL1	6416	5973
STAT3	8126	4982
ZFP57	-749	-781

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_DN

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_DN
metric	value
setSize	160
pMANOVA	0.425
p.adjustMANOVA	0.537
s.dist	0.0535
s.diabetes	-0.0311
s.mitoG	-0.0435
p.diabetes	0.497
p.mitoG	0.343

Top 20 genes
Gene	diabetes	mitoG
DDX17	-6389.0	-6574.0
ZMYM6	-6630.0	-5108.0
TWNK	-6338.0	-5118.0
SDF2	-5624.0	-4467.0
ZKSCAN4	-3447.0	-5890.0
VPS52	-3308.0	-5643.0
ING4	-4464.0	-4099.0
ZSCAN26	-3909.0	-4571.0
CACNG4	-3655.0	-4722.0
PPT2	-5191.5	-2667.5
KCNG1	-4013.0	-2822.0
MLYCD	-6254.0	-1293.0
CYREN	-3549.0	-2232.0
PAX8	-1678.0	-3864.0
CHTOP	-4615.0	-1316.0
NOMO3	-3756.0	-1252.0
FERMT1	-2538.0	-1690.0
KLHL22	-810.5	-5052.5
RNF167	-1219.0	-3078.0
UTP25	-910.0	-3889.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABHD6	6359.0	7038.0
ACSM5	7609.0	-5870.0
ACTN2	-160.0	4310.0
ADGRA2	6742.0	-4913.0
ALKBH1	2546.0	-3262.0
AOC3	-497.0	5099.0
AQP6	5108.0	-1644.0
ARHGAP25	1343.0	6238.0
ARHGAP35	-2056.0	7180.0
ARHGEF5	-5926.0	5828.0
ATXN3L	633.5	4150.5
BICD1	-2065.0	6371.0
BOLA1	2756.0	-4124.0
CACNG4	-3655.0	-4722.0
CBFA2T2	1753.0	5677.0
CBY1	-5032.0	4324.0
CCDC51	3605.0	-4365.0
CD248	537.0	1642.0
CD52	-3982.0	3448.0
CDC123	1994.0	3040.0
CDH11	-3726.0	7616.0
CDKN2C	6608.0	-3067.0
CELSR3	532.0	-1725.0
CHPF	638.0	-574.0
CHTOP	-4615.0	-1316.0
CKAP5	-2537.0	8372.0
COMMD3	-4289.0	8822.0
COQ6	1950.0	-3453.0
CRIPT	-1489.0	8618.0
CSRNP2	6469.0	1246.0
CTF1	601.0	-5358.0
CYP4F12	7297.5	2796.5
CYREN	-3549.0	-2232.0
CZIB	-327.0	2043.0
DARS2	-5166.0	329.0
DDX17	-6389.0	-6574.0
DDX6	-4502.0	5780.0
DENND2D	3945.0	-4019.0
DHX32	-759.0	5873.0
DMWD	1282.0	-6400.0
DNAJA3	-1658.0	5339.0
DNAL4	1096.0	-1389.0
DST	1303.0	1938.0
DYNLRB1	5057.0	-2847.0
DZANK1	5408.0	-4689.0
EFNA3	5736.0	1687.0
EGR2	-1617.0	4130.0
EPOR	7888.0	-2666.0
ERF	8190.0	-6273.0
EXD2	-471.0	839.0
FAM155B	-6604.0	550.0
FAM234B	5197.0	-129.0
FERMT1	-2538.0	-1690.0
FOXO4	257.0	-4431.0
GEMIN6	779.0	3452.0
GLS	5704.0	3155.0
GPR171	-4112.0	6669.0
GPR182	7524.0	5618.0
GPR52	841.0	-5121.0
HDAC11	6709.0	-5647.0
HECTD4	-439.0	-5909.0
HINFP	297.0	1595.0
HOXA2	1984.0	-3355.0
ID3	4145.0	-2671.0
IL11	-3409.0	1307.0
IL23A	-2852.0	2958.0
ING4	-4464.0	-4099.0
INO80B	6545.5	-3302.5
ITFG2	826.0	-4600.0
JAKMIP2	3767.0	-6132.0
KCNG1	-4013.0	-2822.0
KIFBP	-2867.0	1916.0
KLHL22	-810.5	-5052.5
LARGE1	1668.0	1564.0
LIPE	2527.0	415.0
LLGL1	6871.0	-3990.0
LRRC20	7602.0	-584.0
LRRC75B	-548.0	-2539.0
MAP3K20	8060.0	6853.0
MED20	2722.0	-6368.0
MFAP1	-1345.0	8624.0
MFAP3	2866.0	4624.0
MLYCD	-6254.0	-1293.0
MMACHC	1165.0	5604.0
MRPL17	-3013.0	6746.0
MRPL35	-1990.0	4213.0
MTERF3	-5919.0	3270.0
MTHFS	179.5	-3965.5
MUS81	5269.0	-2722.0
N4BP1	-5080.0	168.0
NCKAP1L	-1592.0	4630.0
NDUFA3	4319.0	82.0
NIF3L1	-4467.0	-285.0
NOMO3	-3756.0	-1252.0
NOP10	2308.0	5890.0
ORMDL2	-5602.0	-556.0
PAX8	-1678.0	-3864.0
PEX12	3372.0	1451.0
PGM3	-5155.0	-58.0
PIP5K1A	-1663.0	5148.0
PLEKHA1	4350.0	-2221.0
PLEKHA4	3114.0	-4509.0
PNP	-7335.0	8459.0
POGLUT1	-1880.0	2758.0
POLR3K	-5432.0	6617.0
PPME1	4194.0	3066.0
PPP2R5B	627.0	5414.0
PPT2	-5191.5	-2667.5
PRELID3A	496.0	-5362.0
PTPN21	2719.0	-4215.0
PTRH2	-3116.0	273.0
PUS3	-4535.0	6560.0
RABEPK	2166.0	960.0
RABIF	-2521.0	-1135.0
RALGPS1	2494.0	-5324.0
RNF167	-1219.0	-3078.0
RNF34	48.0	4672.0
RPA3	3029.0	1440.0
RPGR	815.0	-1281.0
RPP38	-3284.0	7004.0
RPS16	6244.0	1119.0
RRAGA	-3310.0	5815.0
RTP4	-2887.0	3910.0
SDF2	-5624.0	-4467.0
SDHAF1	3386.0	2256.0
SEMA6C	6649.0	-2213.0
SLC39A1	3529.0	1673.0
SNX1	-5578.0	5338.0
SNX19	15.0	855.0
SPSB1	7434.0	4252.0
SRPK2	5994.0	1036.0
SSBP2	440.0	2334.0
STAM2	494.0	2564.0
SYNRG	-6000.0	2901.0
TAF5L	3299.0	3056.0
TAPT1	5653.0	5450.0
TEK	-2265.0	8575.0
TGFB3	-1546.0	8322.0
TIMM8B	-1186.0	7371.0
TM6SF2	8051.0	1210.0
TMEM177	-4126.0	2220.0
TMEM223	-3617.0	5440.0
TRIM27	-452.0	-3380.0
TWNK	-6338.0	-5118.0
UBA52	7488.0	-4269.0
UMPS	4556.0	-2755.0
UTP25	-910.0	-3889.0
VPS52	-3308.0	-5643.0
WDR3	-6076.0	2575.0
WDR5B	-3983.0	2770.0
WFDC1	-2408.0	3727.0
YIF1B	5058.0	-3729.0
ZBTB3	-4740.0	1707.0
ZKSCAN4	-3447.0	-5890.0
ZMYM6	-6630.0	-5108.0
ZNF174	3917.0	-6183.0
ZNF189	-6118.0	3732.0
ZNF646	3812.0	2258.0
ZNF764	-229.0	5915.0
ZSCAN26	-3909.0	-4571.0

KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG

KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG
metric	value
setSize	13
pMANOVA	0.435
p.adjustMANOVA	0.537
s.dist	0.22
s.diabetes	0.0887
s.mitoG	-0.201
p.diabetes	0.58
p.mitoG	0.209

Top 20 genes
Gene	diabetes	mitoG
HNF1A	7450	-6675
FOXA3	6771	-2393
NKX6-1	1836	-2277
PKLR	8195	-127

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
BHLHA15	-853	-1895
FOXA3	6771	-2393
HES1	7353	4261
HNF1A	7450	-6675
HNF1B	-1771	-6141
HNF4A	-6855	4619
HNF4G	-6407	-1223
MAFA	-3053	2846
NKX6-1	1836	-2277
NR5A2	-2631	-1601
PAX6	-2974	1272
PKLR	8195	-127
SLC2A2	7902	2301

WP_TYPE_II_DIABETES_MELLITUS

WP_TYPE_II_DIABETES_MELLITUS
metric	value
setSize	20
pMANOVA	0.62
p.adjustMANOVA	0.74
s.dist	0.122
s.diabetes	-0.00833
s.mitoG	-0.121
p.diabetes	0.949
p.mitoG	0.347

Top 20 genes
Gene	diabetes	mitoG
PRKCZ	-2030	-5814
IKBKB	-1785	-5829
MTOR	-4145	-2344

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ADIPOQ	3018.0	-3550.0
CACNA1A	1894.0	-3861.0
GK	-4767.5	4354.5
IKBKB	-1785.0	-5829.0
INSR	3417.0	173.0
IRS1	7064.0	-5549.0
KCNJ11	2961.0	-3265.0
MAFA	-3053.0	2846.0
MAPK1	-3928.0	6920.0
MAPK8	-3252.0	1695.0
MTOR	-4145.0	-2344.0
PHKA2	5251.0	-5498.0
PIK3R5	-1994.0	2879.0
PRKCD	365.0	1901.0
PRKCZ	-2030.0	-5814.0
SLC2A2	7902.0	2301.0
SLC2A4	8055.0	-2624.0
SOCS4	-6470.0	7880.0
SURF1	2134.0	4131.0
TNF	-2778.0	4883.0

GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP

GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP
metric	value
setSize	189
pMANOVA	0.648
p.adjustMANOVA	0.749
s.dist	0.0431
s.diabetes	0.0254
s.mitoG	-0.0348
p.diabetes	0.548
p.mitoG	0.41

Top 20 genes
Gene	diabetes	mitoG
CCDC85B	7941	-6322
DEAF1	7709	-5938
ZNF512B	7028	-6394
NADSYN1	6875	-6478
COTL1	8183	-5409
NSMF	6719	-6004
SNRPF	6058	-6379
ATP5F1E	6241	-5774
ATP5MC3	6278	-5724
MVP	6785	-5147
MFSD10	6323	-5202
RNF126	5755	-4740
POLR2E	7128	-3504
TSR3	4228	-5856
AP5Z1	3582	-6569
SAFB2	3321	-6673
DAZAP1	5026	-4228
SAC3D1	4799	-4190
FBXL15	4607	-4358
VPS51	3048	-6458

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ADNP2	2146.0	595.0
ADRM1	-6170.0	-477.0
AHCY	-3362.0	-6342.0
ANXA6	2396.0	7859.0
AP5Z1	3582.0	-6569.0
APRT	7257.0	-2499.0
ARHGEF1	3750.0	-3695.0
ARPC4	3077.0	1525.0
ATP1B3	-1025.0	8436.0
ATP5F1D	5225.0	673.0
ATP5F1E	6241.0	-5774.0
ATP5MC3	6278.0	-5724.0
ATP5ME	3268.0	3202.0
AURKAIP1	4765.0	3868.0
BCL7C	-6117.0	4975.0
BICRAL	1780.0	-4299.0
BTF3	-2304.0	8350.0
C9orf16	4926.0	854.0
CALM3	-2691.0	4626.0
CAPN15	-874.0	-5739.0
CBX4	3352.0	-2144.0
CCDC22	-4166.0	-3221.0
CCDC85B	7941.0	-6322.0
CD3E	-1202.0	619.0
CD81	3188.0	6614.0
CDC37	-682.0	-4414.0
CDCA4	4122.0	2492.0
CFDP1	-4681.0	7182.0
CFL1	-1720.0	8321.0
CHCHD3	-2623.0	7919.0
CNOT3	1322.0	-5732.0
COPG1	-3891.0	3599.0
COPS7B	-2394.0	-5916.0
CORO1B	40.0	-5224.0
COTL1	8183.0	-5409.0
DAZAP1	5026.0	-4228.0
DBI	-3860.0	5119.0
DDX49	4404.0	-1145.0
DEAF1	7709.0	-5938.0
DGKZ	-6561.0	-2123.0
DNAJC7	-426.0	397.0
DOK2	3914.0	1693.0
DRAP1	5968.0	6776.0
ECSIT	-3596.0	1408.0
EDEM2	-3522.0	-3508.0
EDF1	2958.0	-483.0
EIF3F	2793.0	1790.0
EIF4H	5370.0	-98.0
ELF4	-1062.0	5556.0
ELOC	-3325.0	7837.0
ERH	-4330.0	2173.0
ERP29	-6677.0	-3655.0
FAM53B	6631.0	2759.0
FBXL15	4607.0	-4358.0
FCHO1	3015.0	1348.0
FOXK2	-5706.0	1999.0
GATAD2A	-190.0	5669.0
GID8	-1864.0	6771.0
GLUD1	8064.5	3730.5
GPS2	1228.0	2826.0
GSN	7535.0	7997.0
GTF2F1	373.0	6337.0
GZMM	1140.0	-3497.0
HMG20B	6566.0	-1264.0
HMOX1	-7076.0	8232.0
HNRNPK	-808.0	7246.0
HNRNPM	-6548.0	-2929.0
HNRNPR	-3972.0	1045.0
HNRNPU	-5219.0	7082.0
HNRNPUL1	4431.0	1071.0
HRAS	1503.0	-318.0
HSF1	-1770.0	-3977.0
HSPA9	-566.0	8181.0
ID2	-4980.0	862.0
IDS	-4361.5	6034.5
IDUA	4110.0	3194.0
ILKAP	-3346.0	-3704.0
ILVBL	3004.0	-6442.0
LIMD2	2317.0	1635.0
LIMK1	3519.0	2264.0
LPCAT4	3374.0	1637.0
LRRC47	3220.0	934.0
LSM12	-2869.0	4929.0
LTBP4	-6699.0	5054.0
MAP2K2	-2882.5	-4769.5
MARCKSL1	-107.0	7707.0
MCUR1	-1414.0	1795.0
MDH2	3713.0	4456.0
MEAF6	2763.0	-1411.0
MFNG	-2815.0	5728.0
MFSD10	6323.0	-5202.0
MINK1	-4877.0	-2450.0
MRPL12	-2913.0	4144.0
MRPS15	2010.0	4604.0
MSN	-1294.0	5246.0
MTA1	-1428.0	-2770.0
MVP	6785.0	-5147.0
MYG1	-658.0	-3758.0
MYH9	7189.0	7115.0
NAA60	-1707.0	521.0
NADSYN1	6875.0	-6478.0
NDRG2	-6784.0	2803.0
NDUFB8	4901.5	6790.5
NDUFC1	1620.0	3968.0
NDUFS8	1961.0	2910.0
NONO	-5056.0	5895.0
NSMF	6719.0	-6004.0
NUTF2	-2549.0	1665.0
OSTF1	6553.0	5854.0
PAK2	-4906.0	6708.0
PBX2	3702.0	-1442.0
PCBP1	-6097.0	-710.0
PDAP1	3245.0	700.0
PDIA3	-7283.0	7821.0
PDIA4	-7329.0	7729.0
PDLIM2	6653.0	4632.0
PFDN2	-1073.0	7198.0
PFN1	-3462.0	-4129.0
PKN1	4322.0	-4516.0
POLR2E	7128.0	-3504.0
PPP1R14B	1139.0	-4448.0
PRCC	-3064.0	-3244.0
PRPF31	-387.0	4117.0
PSMB10	3752.0	-908.0
PTBP1	-4264.0	-2729.0
PTPRCAP	-2234.0	-289.0
R3HCC1	7667.0	-1069.0
RAB5C	3703.0	3375.0
RALY	-4431.0	5639.0
RASGRP2	-326.0	-409.0
RBCK1	3790.0	-3921.0
RBM3	8175.0	5192.0
RDH14	2827.0	-2645.0
REX1BD	1924.0	-3848.0
RNF126	5755.0	-4740.0
RNF19B	-3119.0	-1959.0
RNPS1	5559.0	6960.0
RPL37	2109.0	-667.0
RPLP2	3550.0	3555.0
RPN1	-7121.0	7464.0
SAC3D1	4799.0	-4190.0
SAFB	-1933.0	-1132.0
SAFB2	3321.0	-6673.0
SART1	2632.0	-1920.0
SEC61G	-2855.0	8720.0
SERPINF1	645.0	2834.0
SF3A2	1864.0	-5244.0
SF3B4	2644.0	-4321.0
SFPQ	-5196.0	-4828.0
SH3GLB2	284.0	-2915.0
SLC25A1	3746.0	544.0
SLC52A2	-6134.0	-6313.0
SMARCD2	-3787.0	113.0
SMIM10L1	-5327.0	7775.0
SNF8	2397.0	-3270.0
SNRPF	6058.0	-6379.0
SPCS3	4330.0	1501.0
SRP14	372.0	5948.0
SRRM1	5551.0	7062.0
SRSF9	-2009.0	-5029.0
SSBP3	5860.0	-2107.0
SSH1	1827.0	-4164.0
SSRP1	2663.0	4754.0
ST6GALNAC4	-365.0	4860.0
STARD3	-3871.0	-6390.0
STK25	6890.0	2565.0
SUMO3	-7259.0	7825.0
TAF10	-3030.0	2638.0
TGFB1	-1851.0	6152.0
THOC6	-3723.0	-3958.0
TKT	8181.0	2150.0
TLE5	376.0	3434.0
TMED9	-5309.0	-1036.0
TNFRSF14	872.0	-1648.0
TP53	2557.0	-3561.0
TRAPPC2	-3263.0	6403.0
TSPAN14	-6627.0	1158.0
TSR3	4228.0	-5856.0
U2AF2	-2150.0	-825.0
UBE2S	4549.0	-1742.0
UCP2	6987.0	4595.0
UQCRB	-410.0	8334.0
VPS4A	-5731.5	7213.5
VPS51	3048.0	-6458.0
WDR18	-5000.0	-3150.0
WDR45	1445.0	-2878.0
XAB2	2873.0	3916.0
ZNF512B	7028.0	-6394.0
ZNF580	6166.0	515.0

KEGG_TYPE_II_DIABETES_MELLITUS

KEGG_TYPE_II_DIABETES_MELLITUS
metric	value
setSize	41
pMANOVA	0.721
p.adjustMANOVA	0.785
s.dist	0.0692
s.diabetes	0.0108
s.mitoG	0.0684
p.diabetes	0.905
p.mitoG	0.449

Top 20 genes
Gene	diabetes	mitoG
PKM	7561.0	7758.0
HK1	7506.0	4598.0
PIK3R3	3779.5	8820.5
SOCS3	4231.0	7185.0
MAPK3	5390.0	5167.0
MAPK9	2849.0	6624.0
SLC2A2	7902.0	2301.0
SOCS2	4529.0	3280.0
PRKCD	365.0	1901.0
INSR	3417.0	173.0

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ADIPOQ	3018.0	-3550.0
CACNA1A	1894.0	-3861.0
CACNA1C	-234.0	-2843.0
CACNA1D	1453.0	-2159.0
CACNA1E	-3623.0	599.0
CACNA1G	4776.0	-33.0
HK1	7506.0	4598.0
HK2	-1356.0	5521.0
HK3	-4874.0	2139.0
IKBKB	-1785.0	-5829.0
INSR	3417.0	173.0
IRS1	7064.0	-5549.0
IRS2	-582.0	3045.0
KCNJ11	2961.0	-3265.0
MAFA	-3053.0	2846.0
MAPK1	-3928.0	6920.0
MAPK10	-2089.0	-137.0
MAPK3	5390.0	5167.0
MAPK8	-3252.0	1695.0
MAPK9	2849.0	6624.0
MTOR	-4145.0	-2344.0
PIK3CA	-6347.0	2923.0
PIK3CB	-1756.0	1880.0
PIK3CD	-1968.0	1889.0
PIK3CG	-5373.0	8065.0
PIK3R1	-839.0	8363.0
PIK3R2	1669.5	-3969.5
PIK3R3	3779.5	8820.5
PIK3R5	-1994.0	2879.0
PKLR	8195.0	-127.0
PKM	7561.0	7758.0
PRKCD	365.0	1901.0
PRKCE	-5671.0	2371.0
PRKCZ	-2030.0	-5814.0
SLC2A2	7902.0	2301.0
SLC2A4	8055.0	-2624.0
SOCS1	-253.0	-5520.0
SOCS2	4529.0	3280.0
SOCS3	4231.0	7185.0
SOCS4	-6470.0	7880.0
TNF	-2778.0	4883.0

GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_DN

GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_DN
metric	value
setSize	152
pMANOVA	0.721
p.adjustMANOVA	0.785
s.dist	0.035
s.diabetes	0.033
s.mitoG	0.0114
p.diabetes	0.483
p.mitoG	0.808

Top 20 genes
Gene	diabetes	mitoG
COX7B	6102	8760
ABCC2	8240	5236
GSTO1	8023	4922
FERMT2	5215	7566
MCTP2	5673	6385
RAB30	6435	5622
TMPRSS2	7909	4409
S1PR1	4311	7637
MBTPS2	5009	5876
DENND2B	7796	3470
TRPC3	4682	5766
SIAH1	4474	5949
RECK	5456	4804
IL1R1	3443	7288
PSMF1	5087	4771
LFNG	7713	3016
BHLHE41	8219	2676
UPB1	7323	2972
SLC66A3	3663	5856
KCNJ10	3384	6290

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
ABCC2	8240.0	5236.0
ADAMTSL2	1075.0	7367.0
AK2	3153.0	197.0
APOO	-605.0	8803.0
ARFRP1	702.0	-6512.0
ARNT	1247.0	2255.0
ASB4	2909.0	2350.0
ATP6V0E1	1832.0	3873.0
B3GNT2	830.0	-6274.0
BAIAP2	7911.0	534.0
BGLAP	-4940.0	-647.0
BHLHE41	8219.0	2676.0
C4BPA	-1940.0	-3551.0
CA4	-6448.0	2608.0
CACNA1D	1453.0	-2159.0
CD72	-4839.0	3828.0
CDK20	-6202.0	-712.0
CELSR3	532.0	-1725.0
CFAP43	-4048.0	2739.0
CKLF	-2218.0	-2093.0
CLCN4	-6858.0	6649.0
CLDN3	6311.0	-1143.0
CNIH1	-3991.0	8144.0
COL5A3	990.0	-5143.0
COX6A1	5658.0	-2138.0
COX7B	6102.0	8760.0
CPLX2	4986.0	-881.0
DCLK1	1860.0	2862.0
DCTN1	7218.0	-3098.0
DENND2B	7796.0	3470.0
DNAJB4	-4770.0	7917.0
DR1	1246.0	8550.0
DRC3	4772.0	-4087.0
EDN1	-1177.0	7690.0
EIF4E	-4500.0	8429.0
ENTPD7	-6301.0	-4494.0
EPHA1	6217.0	-5787.0
EPHA3	882.0	7728.0
ERI3	5821.0	-4367.0
ETNK1	7979.0	553.0
EXD2	-471.0	839.0
F10	7628.0	-1082.0
FAM114A2	-4892.0	3284.0
FAP	-316.0	2909.0
FCMR	908.0	2646.0
FERMT2	5215.0	7566.0
FGF22	7063.0	-4758.0
FZR1	3996.0	-5000.0
GABRA2	-3873.0	2553.0
GART	-5631.0	-3257.0
GOLIM4	-2600.0	7173.0
GOLPH3L	-5413.0	8354.0
GPRIN2	7637.0	-2891.0
GSTO1	8023.0	4922.0
GUCY1A2	1000.0	5104.0
GUCY2D	2541.0	-2990.0
GUCY2F	2125.0	-5729.0
HAPLN1	-6240.0	1410.0
HS3ST3B1	2983.0	5715.0
HSP90B1	-7279.0	8368.0
HYAL2	-2781.0	-4258.0
IGKC	-2925.0	7318.0
IGKV1D-13	2052.5	4944.5
IL1R1	3443.0	7288.0
INHA	5991.0	-2589.0
ITGB1BP2	1164.0	-5767.0
JMJD4	458.0	-4829.0
KCNJ10	3384.0	6290.0
KCNJ5	2267.0	2954.0
KDM4A	6153.5	-3924.5
KLHDC8A	-3539.0	2328.0
KLRC4	-2897.5	4049.5
KRT23	-660.0	3043.0
LEPROTL1	-4998.0	2148.0
LFNG	7713.0	3016.0
LSM1	1559.0	3093.0
LY6G6D	4861.0	-2442.0
MBD5	-1298.0	-5280.0
MBNL3	3179.0	-2024.0
MBTPS2	5009.0	5876.0
MCTP2	5673.0	6385.0
MDM4	-2223.0	-5305.0
MEF2A	-2071.0	7495.0
MGAT5	-6087.0	2955.0
MTMR6	-5050.0	7595.0
NAV2	-3698.0	-4133.0
NDUFA2	5261.0	-6155.0
NDUFA3	4319.0	82.0
NEDD8	-4578.0	7681.0
NEUROG2	-6666.0	-2042.0
NR1I3	7240.0	-4497.0
NRIP2	-3254.0	-3385.0
NTRK3	5960.0	-263.0
NUMB	-4339.0	4601.0
OBSCN	-2429.0	-3032.0
OR12D3	2342.0	-5876.0
OR7A17	1848.0	-4799.0
OSBPL10	-2744.0	-243.0
P2RY4	-1886.0	-3292.0
PAX8	-1678.0	-3864.0
PCLO	-6586.0	-2014.0
PCSK2	-329.0	-3823.0
PGBD5	316.0	3543.0
PLEKHA4	3114.0	-4509.0
POMP	-6322.0	6114.0
POP1	-6227.0	-4247.0
PPP4R3A	-5758.0	7453.0
PPP5C	565.0	5319.0
PRKAA2	-1063.0	2375.0
PRSS50	4342.5	-1201.5
PSMF1	5087.0	4771.0
PTEN	-5726.0	8365.0
RAB30	6435.0	5622.0
RAB3A	-21.0	-1948.0
RABIF	-2521.0	-1135.0
RAMP1	-1058.0	6011.0
RCC1	-3025.0	-5367.0
RECK	5456.0	4804.0
RENBP	-3824.0	-6639.0
RGS16	-3963.0	3437.0
RHBDD3	5580.0	-6604.0
RHOA	-5203.0	7671.0
S1PR1	4311.0	7637.0
SERPINF2	-6756.0	961.0
SFPQ	-5196.0	-4828.0
SIAH1	4474.0	5949.0
SLC17A4	-3247.0	-3993.0
SLC2A2	7902.0	2301.0
SLC66A3	3663.0	5856.0
SLC7A2	5399.0	-4500.0
SP1	571.0	4734.0
SRRD	1607.0	-1413.0
STAM2	494.0	2564.0
SUMO3	-7259.0	7825.0
TFCP2	8112.0	-6489.0
TFF1	4927.0	-5702.0
TGM3	-987.5	-1853.5
TJP3	7407.0	-1956.0
TMED7	-4902.5	7760.5
TMOD1	1639.0	-1471.0
TMPRSS2	7909.0	4409.0
TRIM45	4625.0	-1893.0
TRMT13	2744.0	786.0
TRPC3	4682.0	5766.0
TSG101	-708.0	7980.0
TSNAX	4076.0	-4048.0
UBA52	7488.0	-4269.0
UPB1	7323.0	2972.0
USP27X	2561.0	1268.0
ZKSCAN8	-809.0	3321.0
ZNF507	-6190.0	1744.0
ZNF764	-229.0	5915.0

HP_INSULIN_RESISTANT_DIABETES_MELLITUS

HP_INSULIN_RESISTANT_DIABETES_MELLITUS
metric	value
setSize	26
pMANOVA	0.761
p.adjustMANOVA	0.804
s.dist	0.0749
s.diabetes	0.041
s.mitoG	0.0627
p.diabetes	0.717
p.mitoG	0.58

Top 20 genes
Gene	diabetes	mitoG
LEPR	6227	8533
STAT3	8126	4982
PLAGL1	6416	5973
KLF11	7284	1719
APPL1	940	7089
LIPE	2527	415
INSR	3417	173

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AGPAT2	-4051	-2429
AKT2	-4939	3281
ALMS1	1616	-638
APPL1	940	7089
BSCL2	4891	-4593
CIDEC	6723	-3643
DCAF17	-5679	335
EIF2AK3	-6386	3372
GATA6	-1651	6694
HNF1A	7450	-6675
HNF4A	-6855	4619
INSR	3417	173
KCNJ11	2961	-3265
KLF11	7284	1719
LEPR	6227	8533
LIPE	2527	415
LMNA	5092	-3667
NSMCE2	5776	-3866
PIK3R1	-839	8363
PLAGL1	6416	5973
PLIN1	-3309	-4723
PPARG	-3636	5654
STAT3	8126	4982
XRCC4	-4715	7026
ZFP57	-749	-781
ZMPSTE24	-6405	5555

HP_DIABETES_INSIPIDUS

HP_DIABETES_INSIPIDUS
metric	value
setSize	33
pMANOVA	0.82
p.adjustMANOVA	0.83
s.dist	0.0576
s.diabetes	0.0529
s.mitoG	0.0229
p.diabetes	0.599
p.mitoG	0.82

Top 20 genes
Gene	diabetes	mitoG
AQP2	8177	5602
AKT1	4859	7244
ROBO1	3335	7441
GPR161	6595	3757
AVPR2	4980	2853
GLA	1196	3449
ARNT2	8205	310
OCRL	3974	593

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
AKT1	4859.0	7244.0
ALMS1	1616.0	-638.0
AQP2	8177.0	5602.0
ARL6	-1042.0	6323.0
ARNT2	8205.0	310.0
AVPR2	4980.0	2853.0
BBS1	3353.5	-2595.5
BRAF	-6284.0	4955.0
CCDC28B	7087.0	-523.0
CDON	-5264.0	357.0
CISD2	-5462.0	6479.0
CNOT1	-2585.0	3418.0
CTNNB1	-6022.0	2664.0
FGFR1	6753.0	-812.0
GLA	1196.0	3449.0
GLI2	-1482.0	794.0
GPR161	6595.0	3757.0
HESX1	5292.0	-1586.0
HLA-DRB1	1762.5	-4711.5
LHX4	-3273.0	943.0
OCRL	3974.0	593.0
PROKR2	-2068.0	-3287.0
PRPS1	-6688.0	3956.0
PTEN	-5726.0	8365.0
PTPN22	-5957.0	3364.0
ROBO1	3335.0	7441.0
SHH	-4143.0	-5003.0
STRADA	5090.0	-5448.0
TP63	-3604.0	1254.0
VIPAS39	-1721.0	3736.0
VPS33B	2918.5	-5911.5
WDR11	7162.0	-4436.0
WFS1	7688.0	-3009.0

TNFR1-induced NFkappaB signaling pathway

TNFR1-induced NFkappaB signaling pathway
metric	value
setSize	26
pMANOVA	0.83
p.adjustMANOVA	0.83
s.dist	0.0633
s.diabetes	0.0226
s.mitoG	0.0591
p.diabetes	0.842
p.mitoG	0.602

Top 20 genes
Gene	diabetes	mitoG
TNFRSF1A	6733	6743
BIRC3	6091	6158
TAB3	3966	5424
MAP3K7	1594	7480
USP2	7977	982
OTUD7B	3158	927
SHARPIN	4794	164

Click HERE to show all gene set members

All member genes
	diabetes	mitoG
BIRC2	-4230.0	3665.0
BIRC3	6091.0	6158.0
CHUK	-3701.0	8556.0
CYLD	-4935.0	4060.0
IKBKB	-1785.0	-5829.0
IKBKG	3700.0	-677.0
MAP3K7	1594.0	7480.0
OTUD7B	3158.0	927.0
RACK1	3367.0	-321.0
RBCK1	3790.0	-3921.0
RIPK1	-2977.0	5088.0
RNF31	6112.5	-6521.5
SHARPIN	4794.0	164.0
TAB1	7839.0	-5339.0
TAB2	-7040.0	7307.0
TAB3	3966.0	5424.0
TNF	-2778.0	4883.0
TNFAIP3	-151.0	2986.0
TNFRSF1A	6733.0	6743.0
TRADD	-1318.0	-2687.0
TRAF1	-3550.0	-834.0
TRAF2	3405.0	-3806.0
USP2	7977.0	982.0
USP21	-4905.0	-5030.0
USP4	-3801.0	1470.0
XIAP	-4862.0	7852.0

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             biomaRt_2.44.1             
##  [7] R.utils_2.10.1              R.oo_1.24.0                
##  [9] R.methodsS3_1.8.1           mitch_1.0.8                
## [11] eulerr_6.1.0                gplots_3.1.0               
## [13] DESeq2_1.28.1               SummarizedExperiment_1.18.2
## [15] DelayedArray_0.14.1         matrixStats_0.57.0         
## [17] Biobase_2.48.0              GenomicRanges_1.40.0       
## [19] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [21] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [23] reshape2_1.4.4              forcats_0.5.0              
## [25] stringr_1.4.0               dplyr_1.0.2                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.2                 tibble_3.0.3               
## [31] ggplot2_3.3.2               tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##   [4] XVector_0.28.0         fs_1.5.0               rstudioapi_0.11       
##   [7] farver_2.0.3           bit64_4.0.5            AnnotationDbi_1.50.3  
##  [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
##  [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.30            
##  [16] polyclip_1.10-0        jsonlite_1.7.1         broom_0.7.1           
##  [19] annotate_1.66.0        dbplyr_1.4.4           shiny_1.5.0           
##  [22] compiler_4.0.2         httr_1.4.2             backports_1.1.10      
##  [25] assertthat_0.2.1       Matrix_1.2-18          fastmap_1.0.1         
##  [28] cli_2.0.2              later_1.1.0.1          prettyunits_1.1.1     
##  [31] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.3 rappdirs_0.3.1        
##  [37] Rcpp_1.0.5             cellranger_1.1.0       vctrs_0.3.4           
##  [40] polylabelr_0.2.0       xfun_0.18              testthat_2.3.2        
##  [43] rvest_0.3.6            mime_0.9               lifecycle_0.2.0       
##  [46] XML_3.99-0.5           zlibbioc_1.34.0        MASS_7.3-53           
##  [49] scales_1.1.1           hms_0.5.3              promises_1.1.1        
##  [52] RColorBrewer_1.1-2     curl_4.3               yaml_2.2.1            
##  [55] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
##  [58] stringi_1.5.3          RSQLite_2.2.1          highr_0.8             
##  [61] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
##  [64] BiocParallel_1.22.0    rlang_0.4.7            pkgconfig_2.0.3       
##  [67] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
##  [70] labeling_0.3           htmlwidgets_1.5.2      bit_4.0.4             
##  [73] tidyselect_1.1.0       plyr_1.8.6             magrittr_1.5          
##  [76] R6_2.4.1               generics_0.0.2         DBI_1.1.0             
##  [79] pillar_1.4.6           haven_2.3.1            withr_2.3.0           
##  [82] survival_3.2-7         RCurl_1.98-1.2         modelr_0.1.8          
##  [85] crayon_1.3.4           KernSmooth_2.23-17     BiocFileCache_1.12.1  
##  [88] rmarkdown_2.4          progress_1.2.2         locfit_1.5-9.4        
##  [91] grid_4.0.2             readxl_1.3.1           blob_1.2.1            
##  [94] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
##  [97] xtable_1.8-4           httpuv_1.5.4           openssl_1.4.3         
## [100] munsell_0.5.0          askpass_1.1

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Gene sets by quadrant

Interactive enrichment scatterplot

A heatmap of S values for top results

A plot of effect size versus significance

Results table

Results (complete table)

Detailed Gene set reports