Mitch Report

date generated: 2022-12-03

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	diab	PMX
0610006L08Rik	-5.5412223	1.7043723
0610007P14Rik	-0.5043192	0.5154128
0610009B22Rik	-1.1468556	0.7601283
0610009E02Rik	-1.0617246	0.7364015
0610009L18Rik	-3.4134523	2.9613348
0610009O20Rik	-1.1413048	1.7889029

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	28178
duplicated_genes_present	0
num_profile_genes_in_sets	1392
num_profile_genes_not_in_sets	26786
profile_pearson_correl	-0.74519
profile_spearman_correl	-0.68447

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	76
num_genesets_excluded	30
num_genesets_included	46

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 10

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 46 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See https://
## haozhu233.github.io/kableExtra/ for details.

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diab	s.PMX	p.diab	p.PMX
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers	42	4.05e-03	0.018600	0.38300	-0.27900	0.26300	1.74e-03	3.22e-03
Apoptotic-cleavage-of-cell-adhesion–proteins	10	6.09e-02	0.166000	0.34600	0.34300	-0.04410	6.00e-02	8.09e-01
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint	71	3.41e-05	0.000523	0.33700	0.15000	-0.30100	2.85e-02	1.11e-05
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest	18	3.47e-02	0.123000	0.33100	0.31500	-0.10000	2.06e-02	4.63e-01
ERBB2-Regulates-Cell-Motility	14	6.13e-02	0.166000	0.32500	0.08050	-0.31400	6.02e-01	4.16e-02
FOXO-mediated-transcription-of-cell-cycle-genes	15	2.62e-01	0.416000	0.31400	0.23600	-0.20700	1.14e-01	1.65e-01
APC/C-mediated-degradation-of-cell-cycle-proteins	85	6.82e-05	0.000628	0.31000	0.15200	-0.27100	1.56e-02	1.57e-05
Regulation-of-mitotic-cell-cycle	85	6.82e-05	0.000628	0.31000	0.15200	-0.27100	1.56e-02	1.57e-05
Regulation-of-necroptotic-cell-death	26	5.72e-02	0.166000	0.29500	0.13300	-0.26300	2.42e-01	2.02e-02
Senescence-Associated-Secretory-Phenotype-(SASP)	48	2.29e-02	0.096000	0.29100	0.22500	-0.18500	6.93e-03	2.65e-02
Downstream-signaling-events-of-B-Cell-Receptor-(BCR)	79	3.30e-06	0.000152	0.27300	0.04770	-0.26800	4.63e-01	3.70e-05
Regulation-of-beta-cell-development	35	1.04e-01	0.217000	0.26700	-0.20100	0.17500	3.91e-02	7.25e-02
Integrin-cell-surface-interactions	64	7.60e-04	0.004370	0.25100	-0.06970	0.24100	3.35e-01	8.62e-04
Aberrant-regulation-of-mitotic-cell-cycle-due-to-RB1-defects	36	7.21e-02	0.182000	0.24700	0.21700	-0.11900	2.42e-02	2.17e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest	13	3.67e-01	0.527000	0.24400	0.21900	-0.10700	1.71e-01	5.02e-01
Diseases-of-mitotic-cell-cycle	38	7.53e-02	0.182000	0.24100	0.21000	-0.11800	2.49e-02	2.08e-01
VEGFR2-mediated-cell-proliferation	19	2.81e-01	0.416000	0.23200	0.20600	-0.10700	1.20e-01	4.20e-01
Cell-Cycle-Checkpoints	249	1.04e-05	0.000238	0.22700	0.15300	-0.16800	3.01e-05	4.81e-06
NRIF-signals-cell-death-from-the-nucleus	15	4.66e-01	0.650000	0.22100	0.12200	-0.18400	4.13e-01	2.17e-01
TP53-Regulates-Transcription-of-Cell-Cycle-Genes	46	4.69e-02	0.154000	0.21700	0.19900	-0.08560	1.95e-02	3.15e-01
Sema4D-induced-cell-migration-and-growth-cone-collapse	19	1.52e-01	0.292000	0.21400	0.21100	-0.03740	1.11e-01	7.78e-01
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters	20	8.70e-02	0.200000	0.18900	0.03000	0.18600	8.17e-01	1.49e-01
MET-promotes-cell-motility	29	2.30e-01	0.378000	0.18600	-0.07010	0.17200	5.13e-01	1.09e-01
Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)	11	7.47e-01	0.920000	0.15200	-0.07560	0.13200	6.64e-01	4.50e-01
FOXO-mediated-transcription-of-cell-death-genes	15	7.17e-01	0.920000	0.15100	-0.09070	0.12100	5.43e-01	4.17e-01
Cell-extracellular-matrix-interactions	16	2.04e-01	0.361000	0.15000	-0.13200	-0.07030	3.59e-01	6.27e-01
Assembly-and-cell-surface-presentation-of-NMDA-receptors	25	9.83e-02	0.215000	0.14300	0.12200	0.07460	2.91e-01	5.18e-01
Cell-Cycle,-Mitotic	479	9.44e-05	0.000724	0.14200	0.11400	-0.08490	1.78e-05	1.41e-03
Cell-junction-organization	78	2.17e-01	0.369000	0.14100	0.11400	-0.08300	8.08e-02	2.05e-01
Cell-Cycle	603	1.23e-04	0.000811	0.12300	0.10100	-0.07100	2.22e-05	2.83e-03
Cell-surface-interactions-at-the-vascular-wall	126	3.05e-02	0.117000	0.11200	-0.01840	0.11100	7.22e-01	3.14e-02
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain	13	8.64e-01	0.946000	0.11200	0.07680	-0.08170	6.32e-01	6.10e-01
Programmed-Cell-Death	185	1.24e-01	0.247000	0.11000	0.06830	-0.08610	1.09e-01	4.31e-02
Signaling-by-the-B-Cell-Receptor-(BCR)	120	2.66e-03	0.013600	0.10200	-0.06580	-0.07850	2.13e-01	1.37e-01
Cell-cell-junction-organization	53	2.74e-01	0.416000	0.09720	0.09700	-0.00576	2.22e-01	9.42e-01
Cell-Cell-communication	110	2.02e-01	0.361000	0.08630	0.08400	-0.01970	1.28e-01	7.21e-01
Cell-recruitment-(pro-inflammatory-response)	24	9.00e-01	0.954000	0.06930	-0.04450	0.05300	7.06e-01	6.53e-01
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain	19	9.33e-01	0.954000	0.06210	0.04880	-0.03840	7.13e-01	7.72e-01
Oxidative-Stress-Induced-Senescence	62	7.86e-01	0.920000	0.05400	-0.04890	0.02290	5.06e-01	7.55e-01
DNA-Damage/Telomere-Stress-Induced-Senescence	28	7.74e-01	0.920000	0.05060	0.00999	0.04960	9.27e-01	6.49e-01
Oncogene-Induced-Senescence	31	7.36e-01	0.920000	0.05040	-0.01480	-0.04810	8.86e-01	6.43e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE	73	5.41e-01	0.732000	0.04960	0.04900	0.00785	4.69e-01	9.08e-01
EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination	27	9.34e-01	0.954000	0.04460	-0.03980	0.02020	7.20e-01	8.56e-01
Diseases-of-programmed-cell-death	42	8.00e-01	0.920000	0.04360	-0.04360	0.00020	6.25e-01	9.98e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes	37	8.40e-01	0.943000	0.03730	0.00550	0.03690	9.54e-01	6.98e-01
Cellular-Senescence	124	9.54e-01	0.954000	0.00952	-0.00377	-0.00874	9.42e-01	8.66e-01

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Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diab	s.PMX	p.diab	p.PMX
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers	42	4.05e-03	0.018600	0.38300	-0.27900	0.26300	1.74e-03	3.22e-03
Apoptotic-cleavage-of-cell-adhesion–proteins	10	6.09e-02	0.166000	0.34600	0.34300	-0.04410	6.00e-02	8.09e-01
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint	71	3.41e-05	0.000523	0.33700	0.15000	-0.30100	2.85e-02	1.11e-05
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest	18	3.47e-02	0.123000	0.33100	0.31500	-0.10000	2.06e-02	4.63e-01
ERBB2-Regulates-Cell-Motility	14	6.13e-02	0.166000	0.32500	0.08050	-0.31400	6.02e-01	4.16e-02
FOXO-mediated-transcription-of-cell-cycle-genes	15	2.62e-01	0.416000	0.31400	0.23600	-0.20700	1.14e-01	1.65e-01
APC/C-mediated-degradation-of-cell-cycle-proteins	85	6.82e-05	0.000628	0.31000	0.15200	-0.27100	1.56e-02	1.57e-05
Regulation-of-mitotic-cell-cycle	85	6.82e-05	0.000628	0.31000	0.15200	-0.27100	1.56e-02	1.57e-05
Regulation-of-necroptotic-cell-death	26	5.72e-02	0.166000	0.29500	0.13300	-0.26300	2.42e-01	2.02e-02
Senescence-Associated-Secretory-Phenotype-(SASP)	48	2.29e-02	0.096000	0.29100	0.22500	-0.18500	6.93e-03	2.65e-02
Downstream-signaling-events-of-B-Cell-Receptor-(BCR)	79	3.30e-06	0.000152	0.27300	0.04770	-0.26800	4.63e-01	3.70e-05
Regulation-of-beta-cell-development	35	1.04e-01	0.217000	0.26700	-0.20100	0.17500	3.91e-02	7.25e-02
Integrin-cell-surface-interactions	64	7.60e-04	0.004370	0.25100	-0.06970	0.24100	3.35e-01	8.62e-04
Aberrant-regulation-of-mitotic-cell-cycle-due-to-RB1-defects	36	7.21e-02	0.182000	0.24700	0.21700	-0.11900	2.42e-02	2.17e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest	13	3.67e-01	0.527000	0.24400	0.21900	-0.10700	1.71e-01	5.02e-01
Diseases-of-mitotic-cell-cycle	38	7.53e-02	0.182000	0.24100	0.21000	-0.11800	2.49e-02	2.08e-01
VEGFR2-mediated-cell-proliferation	19	2.81e-01	0.416000	0.23200	0.20600	-0.10700	1.20e-01	4.20e-01
Cell-Cycle-Checkpoints	249	1.04e-05	0.000238	0.22700	0.15300	-0.16800	3.01e-05	4.81e-06
NRIF-signals-cell-death-from-the-nucleus	15	4.66e-01	0.650000	0.22100	0.12200	-0.18400	4.13e-01	2.17e-01
TP53-Regulates-Transcription-of-Cell-Cycle-Genes	46	4.69e-02	0.154000	0.21700	0.19900	-0.08560	1.95e-02	3.15e-01
Sema4D-induced-cell-migration-and-growth-cone-collapse	19	1.52e-01	0.292000	0.21400	0.21100	-0.03740	1.11e-01	7.78e-01
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters	20	8.70e-02	0.200000	0.18900	0.03000	0.18600	8.17e-01	1.49e-01
MET-promotes-cell-motility	29	2.30e-01	0.378000	0.18600	-0.07010	0.17200	5.13e-01	1.09e-01
Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)	11	7.47e-01	0.920000	0.15200	-0.07560	0.13200	6.64e-01	4.50e-01
FOXO-mediated-transcription-of-cell-death-genes	15	7.17e-01	0.920000	0.15100	-0.09070	0.12100	5.43e-01	4.17e-01
Cell-extracellular-matrix-interactions	16	2.04e-01	0.361000	0.15000	-0.13200	-0.07030	3.59e-01	6.27e-01
Assembly-and-cell-surface-presentation-of-NMDA-receptors	25	9.83e-02	0.215000	0.14300	0.12200	0.07460	2.91e-01	5.18e-01
Cell-Cycle,-Mitotic	479	9.44e-05	0.000724	0.14200	0.11400	-0.08490	1.78e-05	1.41e-03
Cell-junction-organization	78	2.17e-01	0.369000	0.14100	0.11400	-0.08300	8.08e-02	2.05e-01
Cell-Cycle	603	1.23e-04	0.000811	0.12300	0.10100	-0.07100	2.22e-05	2.83e-03
Cell-surface-interactions-at-the-vascular-wall	126	3.05e-02	0.117000	0.11200	-0.01840	0.11100	7.22e-01	3.14e-02
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain	13	8.64e-01	0.946000	0.11200	0.07680	-0.08170	6.32e-01	6.10e-01
Programmed-Cell-Death	185	1.24e-01	0.247000	0.11000	0.06830	-0.08610	1.09e-01	4.31e-02
Signaling-by-the-B-Cell-Receptor-(BCR)	120	2.66e-03	0.013600	0.10200	-0.06580	-0.07850	2.13e-01	1.37e-01
Cell-cell-junction-organization	53	2.74e-01	0.416000	0.09720	0.09700	-0.00576	2.22e-01	9.42e-01
Cell-Cell-communication	110	2.02e-01	0.361000	0.08630	0.08400	-0.01970	1.28e-01	7.21e-01
Cell-recruitment-(pro-inflammatory-response)	24	9.00e-01	0.954000	0.06930	-0.04450	0.05300	7.06e-01	6.53e-01
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain	19	9.33e-01	0.954000	0.06210	0.04880	-0.03840	7.13e-01	7.72e-01
Oxidative-Stress-Induced-Senescence	62	7.86e-01	0.920000	0.05400	-0.04890	0.02290	5.06e-01	7.55e-01
DNA-Damage/Telomere-Stress-Induced-Senescence	28	7.74e-01	0.920000	0.05060	0.00999	0.04960	9.27e-01	6.49e-01
Oncogene-Induced-Senescence	31	7.36e-01	0.920000	0.05040	-0.01480	-0.04810	8.86e-01	6.43e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE	73	5.41e-01	0.732000	0.04960	0.04900	0.00785	4.69e-01	9.08e-01
EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination	27	9.34e-01	0.954000	0.04460	-0.03980	0.02020	7.20e-01	8.56e-01
Diseases-of-programmed-cell-death	42	8.00e-01	0.920000	0.04360	-0.04360	0.00020	6.25e-01	9.98e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes	37	8.40e-01	0.943000	0.03730	0.00550	0.03690	9.54e-01	6.98e-01
Cellular-Senescence	124	9.54e-01	0.954000	0.00952	-0.00377	-0.00874	9.42e-01	8.66e-01

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Detailed Gene set reports

Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers

Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers

metric	value
setSize	42
pMANOVA	0.00405
p.adjustMANOVA	0.0186
s.dist	0.383
s.diab	-0.279
s.PMX	0.263
p.diab	0.00174
p.PMX	0.00322

Top 20 genes

Gene	diab	PMX
Ighd	-11252	12232
Igkc	-12203	11173
Cd79b	-10852	12150
Syk	-11535	11301
Cd22	-11312	11195
Ighm	-9802	12152
Sos1	-11977	9665
Igkv1-135	-9391	12146
Cd79a	-11203	8822
Pik3ap1	-9717	10026
Ptpn6	-8957	10520
Vav1	-9886	7973
Pik3cd	-8249	9542
Igkv17-127	-10984	6315
Fyn	-6985	9856
Btk	-6343	9675
Ighv5-4	-8748	6914
Cd19	-7122	7102
Plcg2	-2480	12667
Ighv9-1	-5234	4881

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcyl1	6832.0	-14545.0
Blk	3046.0	7612.0
Blnk	14946.0	-14514.0
Btk	-6343.0	9675.0
Calm1	152.0	-11443.0
Cd19	-7122.0	7102.0
Cd22	-11312.0	11195.0
Cd79a	-11203.0	8822.0
Cd79b	-10852.0	12150.0
Dapp1	-3460.0	-6642.0
Fyn	-6985.0	9856.0
Grb2	8972.0	3406.0
Ighd	-11252.0	12232.0
Ighm	-9802.0	12152.0
Ighv14-1	-4909.0	-6534.0
Ighv3-1	-3456.5	2317.5
Ighv5-4	-8748.0	6914.0
Ighv9-1	-5234.0	4881.0
Igkc	-12203.0	11173.0
Igkv1-135	-9391.0	12146.0
Igkv14-130	-3167.5	2317.5
Igkv17-127	-10984.0	6315.0
Igkv2-137	6752.0	-10319.0
Igll1	11837.0	-7314.0
Itpr1	10796.0	-11700.0
Itpr2	13551.0	7710.0
Itpr3	11003.0	2102.0
Lyn	-7639.0	6.0
Nck1	-4016.0	-10473.0
Orai1	-6072.0	1991.0
Orai2	10183.0	-2454.0
Pik3ap1	-9717.0	10026.0
Pik3cd	-8249.0	9542.0
Pik3r1	-5226.0	4551.0
Plcg2	-2480.0	12667.0
Ptpn6	-8957.0	10520.0
Sh3kbp1	6066.0	-2951.0
Sos1	-11977.0	9665.0
Stim1	14942.0	-14174.0
Syk	-11535.0	11301.0
Trpc1	-6951.0	-4789.0
Vav1	-9886.0	7973.0

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Apoptotic-cleavage-of-cell-adhesion–proteins

Apoptotic-cleavage-of-cell-adhesion–proteins

metric	value
setSize	10
pMANOVA	0.0609
p.adjustMANOVA	0.166
s.dist	0.346
s.diab	0.343
s.PMX	-0.0441
p.diab	0.06
p.PMX	0.809

Top 20 genes

Gene	diab	PMX
Dsg2	15025	-13950
Ocln	13628	-14190
Dsp	12069	-12608
Casp3	13749	-9807
Pkp1	11012	-12124

Click HERE to show all gene set members

All member genes

	diab	PMX
Casp3	13749	-9807
Cdh1	-174	12292
Ctnnb1	-12039	12412
Dsg1b	7980	4247
Dsg2	15025	-13950
Dsp	12069	-12608
Ocln	13628	-14190
Pkp1	11012	-12124
Tjp1	7975	4697
Tjp2	-7784	12172

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APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint

APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint

metric	value
setSize	71
pMANOVA	3.41e-05
p.adjustMANOVA	0.000523
s.dist	0.337
s.diab	0.15
s.PMX	-0.301
p.diab	0.0285
p.PMX	1.11e-05

Top 20 genes

Gene	diab	PMX
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rps27a	13894	-14715
Psma7	13781	-14022
Psmc3	13783	-13466
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Psmb3	12063	-13952
Nek2	14119	-11365
Ube2d1	11721	-13291
Psmb6	11789	-12835
Psma6	9985	-12478
Psma3	9490	-12548
Cdk1	12509	-9455
Psmb5	10041	-10541
Mad2l1	12617	-8263
Psmb2	7847	-11836
Psmd4	8666	-10398

Click HERE to show all gene set members

All member genes

	diab	PMX
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Bub1b	11232	4229
Bub3	-11165	11759
Ccna2	12043	-6678
Cdc16	10625	-286
Cdc20	13126	-4714
Cdc23	180	8382
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdk1	12509	-9455
Mad2l1	12617	-8263
Nek2	14119	-11365
Psma1	-6738	-7608
Psma2	2844	-13370
Psma3	9490	-12548
Psma4	4617	-12505
Psma5	5504	-11202
Psma6	9985	-12478
Psma7	13781	-14022
Psma8	-7575	7041
Psmb1	6104	-12225
Psmb10	8202	-4783
Psmb11	5872	-6129
Psmb2	7847	-11836
Psmb3	12063	-13952
Psmb4	-4466	-8497
Psmb5	10041	-10541
Psmb6	11789	-12835
Psmb7	175	-13055
Psmb8	-5795	2962
Psmb9	-3858	5687
Psmc1	11705	-6393
Psmc2	-10211	7777
Psmc3	13783	-13466
Psmc4	-7487	10029
Psmc5	5939	-5097
Psmc6	-5320	-12074
Psmd1	-4486	-6816
Psmd10	-5266	7738
Psmd11	-4239	-7981
Psmd12	-5190	-6195
Psmd13	10924	-7634
Psmd14	-9498	2769
Psmd2	-11276	10253
Psmd3	5369	146
Psmd4	8666	-10398
Psmd5	-1595	-6026
Psmd6	-1663	-8390
Psmd7	-9175	-8611
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Psme2b	158	1873
Psme3	-3827	9126
Psme4	-4545	-7955
Psmf1	3006	8610
Rps27a	13894	-14715
Uba52	4596	-6796
Ubb	-3411	-7959
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037

---

---

TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest

TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest

metric	value
setSize	18
pMANOVA	0.0347
p.adjustMANOVA	0.123
s.dist	0.331
s.diab	0.315
s.PMX	-0.1
p.diab	0.0206
p.PMX	0.463

Top 20 genes

Gene	diab	PMX
Pcna	13367	-14114
Tfdp2	12095	-12073
Zfp385a	15036	-8764
Cdk1	12509	-9455
Ccnb1	14031	-8068
Aurka	12135	-7881
Rbl2	11787	-7420
Cdc25c	9859	-6321
Carm1	8621	-6979
Prmt1	12405	-3165
Gadd45a	2843	-9278

Click HERE to show all gene set members

All member genes

	diab	PMX
Aurka	12135	-7881
Bax	11957	8555
Carm1	8621	-6979
Ccnb1	14031	-8068
Cdc25c	9859	-6321
Cdk1	12509	-9455
E2f4	-8258	5909
Ep300	-10091	9600
Gadd45a	2843	-9278
Pcna	13367	-14114
Prmt1	12405	-3165
Rbl1	-9375	11563
Rbl2	11787	-7420
Sfn	9301	71
Tfdp1	-7152	7854
Tfdp2	12095	-12073
Trp53	-7681	5460
Zfp385a	15036	-8764

---

---

ERBB2-Regulates-Cell-Motility

ERBB2-Regulates-Cell-Motility

metric	value
setSize	14
pMANOVA	0.0613
p.adjustMANOVA	0.166
s.dist	0.325
s.diab	0.0805
s.PMX	-0.314
p.diab	0.602
p.PMX	0.0416

Top 20 genes

Gene	diab	PMX
Diaph1	15185.0	-14589.0
Btc	14781.0	-12517.0
Erbb4	11714.0	-13547.0
Erbb3	7910.0	-12688.0
Nrg2	6153.0	-9590.0
Nrg3	1803.5	-1222.5

Click HERE to show all gene set members

All member genes

	diab	PMX
Btc	14781.0	-12517.0
Diaph1	15185.0	-14589.0
Egf	-9319.0	1676.0
Egfr	-4839.0	7088.0
Erbb2	-310.0	-10575.0
Erbb3	7910.0	-12688.0
Erbb4	11714.0	-13547.0
Ereg	1803.5	699.0
Hbegf	-6264.0	-7909.0
Memo1	-6848.0	-2919.0
Nrg1	7244.0	7473.0
Nrg2	6153.0	-9590.0
Nrg3	1803.5	-1222.5
Nrg4	-4847.0	-8269.0

---

---

FOXO-mediated-transcription-of-cell-cycle-genes

FOXO-mediated-transcription-of-cell-cycle-genes

metric	value
setSize	15
pMANOVA	0.262
p.adjustMANOVA	0.416
s.dist	0.314
s.diab	0.236
s.PMX	-0.207
p.diab	0.114
p.PMX	0.165

Top 20 genes

Gene	diab	PMX
Btg1	15032	-15019
Foxo3	14625	-14429
Klf4	13879	-14736
Ccng2	13968	-14417
Cdkn1a	15394	-12557
Rbl2	11787	-7420
Foxo1	8079	-10792
Smad4	10397	-4745
Gadd45a	2843	-9278

Click HERE to show all gene set members

All member genes

	diab	PMX
Btg1	15032	-15019
Cav1	-3675	10920
Ccng2	13968	-14417
Cdkn1a	15394	-12557
Cdkn1b	4380	258
Foxo1	8079	-10792
Foxo3	14625	-14429
Foxo4	-4785	2785
Gadd45a	2843	-9278
Klf4	13879	-14736
Pcbp4	-10989	12360
Rbl2	11787	-7420
Smad2	-9935	4570
Smad3	-11617	12814
Smad4	10397	-4745

---

---

APC/C-mediated-degradation-of-cell-cycle-proteins

APC/C-mediated-degradation-of-cell-cycle-proteins

metric	value
setSize	85
pMANOVA	6.82e-05
p.adjustMANOVA	0.000628
s.dist	0.31
s.diab	0.152
s.PMX	-0.271
p.diab	0.0156
p.PMX	1.57e-05

Top 20 genes

Gene	diab	PMX
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rb1	15102	-13818
Rps27a	13894	-14715
Psma7	13781	-14022
Psmc3	13783	-13466
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Psmb3	12063	-13952
Nek2	14119	-11365
Cdk2	12902	-12285
Ube2d1	11721	-13291
Pttg1	13199	-11759
Psmb6	11789	-12835
Psma6	9985	-12478
Psma3	9490	-12548
Cdk1	12509	-9455
Ccnb1	14031	-8068

Click HERE to show all gene set members

All member genes

	diab	PMX
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Aurka	12135	-7881
Aurkb	6296	-7654
Btrc	-1383	8479
Bub1b	11232	4229
Bub3	-11165	11759
Ccna2	12043	-6678
Ccnb1	14031	-8068
Cdc14a	-8389	10394
Cdc16	10625	-286
Cdc20	13126	-4714
Cdc23	180	8382
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdk1	12509	-9455
Cdk2	12902	-12285
Cul1	114	-11623
Fbxo5	-1870	5491
Fzr1	-2715	9851
Mad2l1	12617	-8263
Nek2	14119	-11365
Plk1	9395	-5777
Psma1	-6738	-7608
Psma2	2844	-13370
Psma3	9490	-12548
Psma4	4617	-12505
Psma5	5504	-11202
Psma6	9985	-12478
Psma7	13781	-14022
Psma8	-7575	7041
Psmb1	6104	-12225
Psmb10	8202	-4783
Psmb11	5872	-6129
Psmb2	7847	-11836
Psmb3	12063	-13952
Psmb4	-4466	-8497
Psmb5	10041	-10541
Psmb6	11789	-12835
Psmb7	175	-13055
Psmb8	-5795	2962
Psmb9	-3858	5687
Psmc1	11705	-6393
Psmc2	-10211	7777
Psmc3	13783	-13466
Psmc4	-7487	10029
Psmc5	5939	-5097
Psmc6	-5320	-12074
Psmd1	-4486	-6816
Psmd10	-5266	7738
Psmd11	-4239	-7981
Psmd12	-5190	-6195
Psmd13	10924	-7634
Psmd14	-9498	2769
Psmd2	-11276	10253
Psmd3	5369	146
Psmd4	8666	-10398
Psmd5	-1595	-6026
Psmd6	-1663	-8390
Psmd7	-9175	-8611
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Psme2b	158	1873
Psme3	-3827	9126
Psme4	-4545	-7955
Psmf1	3006	8610
Pttg1	13199	-11759
Rb1	15102	-13818
Rps27a	13894	-14715
Skp1a	-9392	1413
Skp2	-9937	5846
Uba52	4596	-6796
Ubb	-3411	-7959
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037

---

---

Regulation-of-mitotic-cell-cycle

Regulation-of-mitotic-cell-cycle

metric	value
setSize	85
pMANOVA	6.82e-05
p.adjustMANOVA	0.000628
s.dist	0.31
s.diab	0.152
s.PMX	-0.271
p.diab	0.0156
p.PMX	1.57e-05

Top 20 genes

Gene	diab	PMX
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rb1	15102	-13818
Rps27a	13894	-14715
Psma7	13781	-14022
Psmc3	13783	-13466
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Psmb3	12063	-13952
Nek2	14119	-11365
Cdk2	12902	-12285
Ube2d1	11721	-13291
Pttg1	13199	-11759
Psmb6	11789	-12835
Psma6	9985	-12478
Psma3	9490	-12548
Cdk1	12509	-9455
Ccnb1	14031	-8068

Click HERE to show all gene set members

All member genes

	diab	PMX
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Aurka	12135	-7881
Aurkb	6296	-7654
Btrc	-1383	8479
Bub1b	11232	4229
Bub3	-11165	11759
Ccna2	12043	-6678
Ccnb1	14031	-8068
Cdc14a	-8389	10394
Cdc16	10625	-286
Cdc20	13126	-4714
Cdc23	180	8382
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdk1	12509	-9455
Cdk2	12902	-12285
Cul1	114	-11623
Fbxo5	-1870	5491
Fzr1	-2715	9851
Mad2l1	12617	-8263
Nek2	14119	-11365
Plk1	9395	-5777
Psma1	-6738	-7608
Psma2	2844	-13370
Psma3	9490	-12548
Psma4	4617	-12505
Psma5	5504	-11202
Psma6	9985	-12478
Psma7	13781	-14022
Psma8	-7575	7041
Psmb1	6104	-12225
Psmb10	8202	-4783
Psmb11	5872	-6129
Psmb2	7847	-11836
Psmb3	12063	-13952
Psmb4	-4466	-8497
Psmb5	10041	-10541
Psmb6	11789	-12835
Psmb7	175	-13055
Psmb8	-5795	2962
Psmb9	-3858	5687
Psmc1	11705	-6393
Psmc2	-10211	7777
Psmc3	13783	-13466
Psmc4	-7487	10029
Psmc5	5939	-5097
Psmc6	-5320	-12074
Psmd1	-4486	-6816
Psmd10	-5266	7738
Psmd11	-4239	-7981
Psmd12	-5190	-6195
Psmd13	10924	-7634
Psmd14	-9498	2769
Psmd2	-11276	10253
Psmd3	5369	146
Psmd4	8666	-10398
Psmd5	-1595	-6026
Psmd6	-1663	-8390
Psmd7	-9175	-8611
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Psme2b	158	1873
Psme3	-3827	9126
Psme4	-4545	-7955
Psmf1	3006	8610
Pttg1	13199	-11759
Rb1	15102	-13818
Rps27a	13894	-14715
Skp1a	-9392	1413
Skp2	-9937	5846
Uba52	4596	-6796
Ubb	-3411	-7959
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037

---

---

Regulation-of-necroptotic-cell-death

Regulation-of-necroptotic-cell-death

metric	value
setSize	26
pMANOVA	0.0572
p.adjustMANOVA	0.166
s.dist	0.295
s.diab	0.133
s.PMX	-0.263
p.diab	0.242
p.PMX	0.0202

Top 20 genes

Gene	diab	PMX
Sdcbp	15153	-15107
Rps27a	13894	-14715
Flot1	14308	-13529
Birc3	14412	-13340
Fas	13656	-13454
Flot2	13212	-12960
Cflar	9464	-13798
Mlkl	11932	-10030
Peli1	8961	-12690
Birc2	7611	-10452
Uba52	4596	-6796
Traf2	3101	-8023
Ripk3	7523	-131

Click HERE to show all gene set members

All member genes

	diab	PMX
Birc2	7611	-10452
Birc3	14412	-13340
Casp8	-8679	-12376
Cdc37	-1879	-4421
Cflar	9464	-13798
Fadd	-9345	10811
Fas	13656	-13454
Fasl	-3718	6336
Flot1	14308	-13529
Flot2	13212	-12960
Hsp90aa1	-12505	4614
Mlkl	11932	-10030
Ogt	-3769	-9582
Pdcd6ip	-5824	3458
Peli1	8961	-12690
Ripk1	-961	-5249
Ripk3	7523	-131
Rps27a	13894	-14715
Sdcbp	15153	-15107
Stub1	122	4556
Tnfrsf10b	14466	8404
Tnfsf10	-12009	11185
Tradd	-7820	11319
Traf2	3101	-8023
Uba52	4596	-6796
Ubb	-3411	-7959

---

---

Senescence-Associated-Secretory-Phenotype-(SASP)

Senescence-Associated-Secretory-Phenotype-(SASP)

metric	value
setSize	48
pMANOVA	0.0229
p.adjustMANOVA	0.096
s.dist	0.291
s.diab	0.225
s.PMX	-0.185
p.diab	0.00693
p.PMX	0.0265

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Stat3	14430	-14454
Cdkn2b	14383	-14293
Rps27a	13894	-14715
Cdkn1a	15394	-12557
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Cdk2	12902	-12285
Ube2d1	11721	-13291
Rps6ka2	14482	-10261
Jun	9574	-13518
Rela	7998	-10978
Ccna2	12043	-6678
Ube2c	9861	-8024
Mapk3	10588	-6813
Mapk1	6867	-10406
Anapc7	10824	-6183
Ube2s	9693	-6037
Cdc26	8205	-5823

Click HERE to show all gene set members

All member genes

	diab	PMX
Anapc1	-11278.0	10450.0
Anapc10	-40.0	-7692.0
Anapc11	-4767.0	-2276.0
Anapc15	-2513.0	-9553.0
Anapc16	13128.0	-13447.0
Anapc2	-3217.0	9388.0
Anapc4	14276.0	-12248.0
Anapc5	14536.0	-12088.0
Anapc7	10824.0	-6183.0
Ccna2	12043.0	-6678.0
Cdc16	10625.0	-286.0
Cdc23	180.0	8382.0
Cdc26	8205.0	-5823.0
Cdc27	-6730.0	-6274.0
Cdk2	12902.0	-12285.0
Cdk4	7497.0	6438.0
Cdk6	-8022.0	-8784.0
Cdkn1a	15394.0	-12557.0
Cdkn1b	4380.0	258.0
Cdkn2b	14383.0	-14293.0
Cdkn2c	-1158.0	9132.0
Cdkn2d	5293.0	2129.0
Cebpb	15167.0	-15133.0
Ehmt1	-4418.0	-10516.0
Ehmt2	4354.0	10437.0
Fos	5077.0	22.0
Fzr1	-2715.0	9851.0
H2afx	-3852.0	6424.0
Igfbp7	-6756.0	-9670.0
Il1a	876.5	-1222.5
Il6	-2929.0	3096.0
Jun	9574.0	-13518.0
Mapk1	6867.0	-10406.0
Mapk3	10588.0	-6813.0
Mapk7	-1452.0	6080.0
Nfkb1	234.0	10216.0
Rela	7998.0	-10978.0
Rps27a	13894.0	-14715.0
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Stat3	14430.0	-14454.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2c	9861.0	-8024.0
Ube2d1	11721.0	-13291.0
Ube2e1	-10811.0	7252.0
Ube2s	9693.0	-6037.0

---

---

Downstream-signaling-events-of-B-Cell-Receptor-(BCR)

Downstream-signaling-events-of-B-Cell-Receptor-(BCR)

metric	value
setSize	79
pMANOVA	3.3e-06
p.adjustMANOVA	0.000152
s.dist	0.273
s.diab	0.0477
s.PMX	-0.268
p.diab	0.463
p.PMX	3.7e-05

Top 20 genes

Gene	diab	PMX
Nfkbia	14941	-14953
Ppia	14608	-14924
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rps27a	13894	-14715
Psma7	13781	-14022
Psmc3	13783	-13466
Psmb3	12063	-13952
Psmb6	11789	-12835
Hras	12615	-11955
Nras	11707	-12390
Ikbkg	12618	-11493
Nfkbib	12056	-11601
Psma6	9985	-12478
Psma3	9490	-12548
Map3k7	10607	-11166
Rel	10291	-11414
Ppp3ca	12376	-9089
Psmb5	10041	-10541

Click HERE to show all gene set members

All member genes

	diab	PMX
Bcl10	-5706	6387
Btrc	-1383	8479
Calm1	152	-11443
Card11	-7798	11685
Chuk	-8103	-8635
Cul1	114	-11623
Fbxw11	-10435	9702
Fkbp1a	-4088	2763
Hras	12615	-11955
Ikbkb	-1527	-10168
Ikbkg	12618	-11493
Kras	8243	-12396
Malt1	-6834	10147
Map3k7	10607	-11166
Nfatc1	-2618	-8153
Nfatc2	9333	9956
Nfatc3	-9186	3699
Nfkb1	234	10216
Nfkbia	14941	-14953
Nfkbib	12056	-11601
Nfkbie	-7903	8218
Nras	11707	-12390
Ppia	14608	-14924
Ppp3ca	12376	-9089
Ppp3cb	-6472	4604
Ppp3r1	8691	-9297
Prkcb	-7742	7077
Psma1	-6738	-7608
Psma2	2844	-13370
Psma3	9490	-12548
Psma4	4617	-12505
Psma5	5504	-11202
Psma6	9985	-12478
Psma7	13781	-14022
Psma8	-7575	7041
Psmb1	6104	-12225
Psmb10	8202	-4783
Psmb11	5872	-6129
Psmb2	7847	-11836
Psmb3	12063	-13952
Psmb4	-4466	-8497
Psmb5	10041	-10541
Psmb6	11789	-12835
Psmb7	175	-13055
Psmb8	-5795	2962
Psmb9	-3858	5687
Psmc1	11705	-6393
Psmc2	-10211	7777
Psmc3	13783	-13466
Psmc4	-7487	10029
Psmc5	5939	-5097
Psmc6	-5320	-12074
Psmd1	-4486	-6816
Psmd10	-5266	7738
Psmd11	-4239	-7981
Psmd12	-5190	-6195
Psmd13	10924	-7634
Psmd14	-9498	2769
Psmd2	-11276	10253
Psmd3	5369	146
Psmd4	8666	-10398
Psmd5	-1595	-6026
Psmd6	-1663	-8390
Psmd7	-9175	-8611
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Psme2b	158	1873
Psme3	-3827	9126
Psme4	-4545	-7955
Psmf1	3006	8610
Rasgrp1	-3739	-13175
Rasgrp3	-12035	12755
Rel	10291	-11414
Rela	7998	-10978
Rps27a	13894	-14715
Skp1a	-9392	1413
Uba52	4596	-6796
Ubb	-3411	-7959

---

---

Regulation-of-beta-cell-development

Regulation-of-beta-cell-development

metric	value
setSize	35
pMANOVA	0.104
p.adjustMANOVA	0.217
s.dist	0.267
s.diab	-0.201
s.PMX	0.175
p.diab	0.0391
p.PMX	0.0725

Top 20 genes

Gene	diab	PMX
Hnf1b	-12434	12749
Hes1	-12015	11774
Kat2a	-10869	12432
Hnf4a	-11415	11016
Hnf4g	-12654	9829
Akt2	-10282	10289
Nr5a2	-10147	10004
Ep300	-10091	9600
Maml1	-10807	8005
Hnf1a	-10121	6985
Notch1	-8821	7415
Foxa3	-7263	7425
Mafa	-5950	6802
Gck	-7462	1439
Mamld1	-1846	4284
Kat2b	-8046	291

Click HERE to show all gene set members

All member genes

	diab	PMX
Akt1	11899.0	-4407.0
Akt2	-10282.0	10289.0
Akt3	-23.0	-6307.0
Crebbp	7115.0	-7498.0
Ep300	-10091.0	9600.0
Fgf10	-8605.0	-10192.0
Foxa2	2533.5	3915.0
Foxa3	-7263.0	7425.0
Foxo1	8079.0	-10792.0
Gck	-7462.0	1439.0
Hes1	-12015.0	11774.0
Hnf1a	-10121.0	6985.0
Hnf1b	-12434.0	12749.0
Hnf4a	-11415.0	11016.0
Hnf4g	-12654.0	9829.0
Ins2	3527.5	4487.0
Kat2a	-10869.0	12432.0
Kat2b	-8046.0	291.0
Mafa	-5950.0	6802.0
Maml1	-10807.0	8005.0
Maml2	9185.0	8307.0
Maml3	14706.0	-12992.0
Mamld1	-1846.0	4284.0
Neurod1	876.5	-1222.5
Nkx2-2	2785.0	-7084.0
Nkx6-1	3912.0	8261.0
Notch1	-8821.0	7415.0
Nr5a2	-10147.0	10004.0
Onecut3	1803.5	3123.0
Pax6	5690.5	-5972.0
Pklr	15118.0	-15004.0
Ptf1a	876.5	-1222.5
Rbpj	-8609.0	-6259.0
Slc2a2	14424.0	-9637.0
Snw1	11427.0	-10740.0

---

---

Integrin-cell-surface-interactions

Integrin-cell-surface-interactions

metric	value
setSize	64
pMANOVA	0.00076
p.adjustMANOVA	0.00437
s.dist	0.251
s.diab	-0.0697
s.PMX	0.241
p.diab	0.335
p.PMX	0.000862

Top 20 genes

Gene	diab	PMX
Kdr	-12645	12884
Itgax	-12597	12908
Itgb7	-12362	12913
Itga9	-12089	12867
Itgb6	-12023	12923
Itgal	-11771	12813
Jam3	-11372	12730
Col16a1	-12297	11347
Cd44	-11921	11492
Itga4	-10182	12732
Icam2	-10654	12128
Col4a4	-10655	12060
Hspg2	-9709	12765
Pecam1	-9053	12320
Itga8	-9554	11089
Vcam1	-10545	8429
Col4a3	-8719	8992
Col9a3	-7324	5896
Itgam	-8058	4871
Icam5	-4768	7615

Click HERE to show all gene set members

All member genes

	diab	PMX
Agrn	-2557.0	10075.0
Bsg	10831.0	-9772.0
Cd44	-11921.0	11492.0
Cd47	-5391.0	-2458.0
Cdh1	-174.0	12292.0
Col13a1	13283.0	-13105.0
Col16a1	-12297.0	11347.0
Col18a1	12226.0	5466.0
Col23a1	6766.0	-9684.0
Col4a1	5904.0	7644.0
Col4a2	12342.0	7010.0
Col4a3	-8719.0	8992.0
Col4a4	-10655.0	12060.0
Col9a1	-1304.5	3868.0
Col9a2	4094.0	1499.0
Col9a3	-7324.0	5896.0
Comp	13019.0	-12258.0
F11r	11089.0	-13222.0
Fbn1	-1557.0	11139.0
Fga	14188.0	-14645.0
Fgb	13155.0	-10094.0
Fgg	14936.0	-14182.0
Fn1	12346.0	6126.0
Hspg2	-9709.0	12765.0
Icam1	12408.0	-14411.0
Icam2	-10654.0	12128.0
Icam4	-187.0	1799.0
Icam5	-4768.0	7615.0
Itga1	9086.0	6502.0
Itga10	-7763.0	-6633.0
Itga11	11456.0	11485.0
Itga2	7236.0	-6041.0
Itga2b	4836.0	-5064.0
Itga3	9099.0	6566.0
Itga4	-10182.0	12732.0
Itga5	-6316.0	4295.0
Itga6	10749.0	-2876.0
Itga7	11604.0	-4725.0
Itga8	-9554.0	11089.0
Itga9	-12089.0	12867.0
Itgad	-3776.0	1513.5
Itgae	-4002.0	8879.0
Itgal	-11771.0	12813.0
Itgam	-8058.0	4871.0
Itgav	14776.0	-14797.0
Itgax	-12597.0	12908.0
Itgb1	5869.0	-13098.0
Itgb2l	4949.0	-3001.0
Itgb3	12310.0	-13769.0
Itgb5	3113.0	12053.0
Itgb6	-12023.0	12923.0
Itgb7	-12362.0	12913.0
Itgb8	-8645.0	-5178.0
Jam2	-8656.0	-7659.0
Jam3	-11372.0	12730.0
Kdr	-12645.0	12884.0
Lum	-2412.0	11141.0
Madcam1	4094.0	-2795.0
Pecam1	-9053.0	12320.0
Spp1	15190.0	-14758.0
Thbs1	4377.0	10927.0
Tnc	5679.0	9966.0
Vcam1	-10545.0	8429.0
Vtn	-9042.0	-9360.0

---

---

Aberrant-regulation-of-mitotic-cell-cycle-due-to-RB1-defects

Aberrant-regulation-of-mitotic-cell-cycle-due-to-RB1-defects

metric	value
setSize	36
pMANOVA	0.0721
p.adjustMANOVA	0.182
s.dist	0.247
s.diab	0.217
s.PMX	-0.119
p.diab	0.0242
p.PMX	0.217

Top 20 genes

Gene	diab	PMX
Ccnd3	15351	-15060
Rb1	15102	-13818
E2f1	14773	-13127
Cdkn1a	15394	-12557
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Cdk2	12902	-12285
Ube2d1	11721	-13291
Tfdp2	12095	-12073
Ccne1	8507	-10924
Ube2c	9861	-8024
Anapc7	10824	-6183
Ube2s	9693	-6037
Ccne2	4837	-11061
Cdc26	8205	-5823
Cdc16	10625	-286

Click HERE to show all gene set members

All member genes

	diab	PMX
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Ccnd1	10280	12715
Ccnd2	-10391	11271
Ccnd3	15351	-15060
Ccne1	8507	-10924
Ccne2	4837	-11061
Cdc16	10625	-286
Cdc23	180	8382
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdk2	12902	-12285
Cdk4	7497	6438
Cdk6	-8022	-8784
Cdkn1a	15394	-12557
Cdkn1b	4380	258
Cdkn1c	11412	12041
E2f1	14773	-13127
E2f2	-10922	8773
E2f3	9873	3869
Fzr1	-2715	9851
Rb1	15102	-13818
Skp2	-9937	5846
Tfdp1	-7152	7854
Tfdp2	12095	-12073
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037

---

---

TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest

TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest

metric	value
setSize	13
pMANOVA	0.367
p.adjustMANOVA	0.527
s.dist	0.244
s.diab	0.219
s.PMX	-0.107
p.diab	0.171
p.PMX	0.502

Top 20 genes

Gene	diab	PMX
E2f1	14773	-13127
Cdkn1a	15394	-12557
Cdk2	12902	-12285
Zfp385a	15036	-8764
Ccne1	8507	-10924
Ccna2	12043	-6678
Ccne2	4837	-11061

Click HERE to show all gene set members

All member genes

	diab	PMX
Arid3a	-9238	8570
Ccna2	12043	-6678
Ccne1	8507	-10924
Ccne2	4837	-11061
Cdk2	12902	-12285
Cdkn1a	15394	-12557
Cdkn1b	4380	258
E2f1	14773	-13127
E2f7	-6064	9808
E2f8	3208	5434
Pcbp4	-10989	12360
Trp53	-7681	5460
Zfp385a	15036	-8764

---

---

Diseases-of-mitotic-cell-cycle

Diseases-of-mitotic-cell-cycle

metric	value
setSize	38
pMANOVA	0.0753
p.adjustMANOVA	0.182
s.dist	0.241
s.diab	0.21
s.PMX	-0.118
p.diab	0.0249
p.PMX	0.208

Top 20 genes

Gene	diab	PMX
Ccnd3	15351	-15060
Rb1	15102	-13818
E2f1	14773	-13127
Cdkn1a	15394	-12557
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Cdk2	12902	-12285
Ube2d1	11721	-13291
Tfdp2	12095	-12073
Atrx	11763	-12296
Ccne1	8507	-10924
Ube2c	9861	-8024
Anapc7	10824	-6183
Ube2s	9693	-6037
Ccne2	4837	-11061
Cdc26	8205	-5823
Cdc16	10625	-286

Click HERE to show all gene set members

All member genes

	diab	PMX
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Atrx	11763	-12296
Ccnd1	10280	12715
Ccnd2	-10391	11271
Ccnd3	15351	-15060
Ccne1	8507	-10924
Ccne2	4837	-11061
Cdc16	10625	-286
Cdc23	180	8382
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdk2	12902	-12285
Cdk4	7497	6438
Cdk6	-8022	-8784
Cdkn1a	15394	-12557
Cdkn1b	4380	258
Cdkn1c	11412	12041
Daxx	-6696	7271
E2f1	14773	-13127
E2f2	-10922	8773
E2f3	9873	3869
Fzr1	-2715	9851
Rb1	15102	-13818
Skp2	-9937	5846
Tfdp1	-7152	7854
Tfdp2	12095	-12073
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037

---

---

VEGFR2-mediated-cell-proliferation

VEGFR2-mediated-cell-proliferation

metric	value
setSize	19
pMANOVA	0.281
p.adjustMANOVA	0.416
s.dist	0.232
s.diab	0.206
s.PMX	-0.107
p.diab	0.12
p.PMX	0.42

Top 20 genes

Gene	diab	PMX
Plcg1	15140	-14853
Sphk1	14600	-15084
Hras	12615	-11955
Pdpk1	11828	-12301
Nras	11707	-12390
Itpr1	10796	-11700
Kras	8243	-12396
Prkcd	11350	-8872
Ahcyl1	6832	-14545
Calm1	152	-11443

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcyl1	6832	-14545
Calm1	152	-11443
Hras	12615	-11955
Itpr1	10796	-11700
Itpr2	13551	7710
Itpr3	11003	2102
Kdr	-12645	12884
Kras	8243	-12396
Nras	11707	-12390
Pdpk1	11828	-12301
Plcg1	15140	-14853
Prkca	-11577	11021
Prkcb	-7742	7077
Prkcd	11350	-8872
Prkcz	-5521	12776
Rasa1	-6341	6192
Sphk1	14600	-15084
Src	8646	4243
Vegfa	-12713	12720

---

---

Cell-Cycle-Checkpoints

Cell-Cycle-Checkpoints

metric	value
setSize	249
pMANOVA	1.04e-05
p.adjustMANOVA	0.000238
s.dist	0.227
s.diab	0.153
s.PMX	-0.168
p.diab	3.01e-05
p.PMX	4.81e-06

Top 20 genes

Gene	diab	PMX
Spc25	15273	-15132
Ppp2r5a	14617	-14818
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Brca1	14765	-14101
Rps27a	13894	-14715
Rps27	13829	-14647
Dync1i2	13930	-14334
Dync1li2	13775	-14349
Cdkn1a	15394	-12557
Psma7	13781	-14022
Ppp2cb	14291	-13381
Zwint	12999	-14462
Psmc3	13783	-13466
Rbbp8	13717	-12966
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Bre	14292	-12007

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahctf1	-10865	-10185
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Atm	11462	2585
Atr	4265	-9369
Atrip	8548	-28
Aurkb	6296	-7654
B9d2	-5649	8837
Babam1	-5669	6529
Bard1	7141	-328
Birc5	12522	-11275
Blm	13734	-11646
Brca1	14765	-14101
Brcc3	3410	-9434
Bre	14292	-12007
Brip1	12955	-13168
Bub1	7301	7957
Bub1b	11232	4229
Bub3	-11165	11759
Ccna2	12043	-6678
Ccnb1	14031	-8068
Ccnb2	10799	-9616
Ccne1	8507	-10924
Ccne2	4837	-11061
Cdc16	10625	-286
Cdc20	13126	-4714
Cdc23	180	8382
Cdc25a	3462	-12613
Cdc25c	9859	-6321
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdc45	8657	-7688
Cdc6	-2324	4582
Cdc7	-9107	8769
Cdca8	3238	-2833
Cdk1	12509	-9455
Cdk2	12902	-12285
Cdkn1a	15394	-12557
Cdkn1b	4380	258
Cenpa	3435	5318
Cenpc1	-3272	-8022
Cenpe	4365	-6647
Cenpf	13427	-379
Cenph	10433	-9250
Cenpi	8123	-7481
Cenpk	9317	-8016
Cenpl	-1784	-10457
Cenpm	11559	-9488
Cenpn	9068	4694
Cenpo	4588	-8699
Cenpp	5610	4078
Cenpq	-8830	-3341
Cenpt	13110	-10179
Cenpu	11737	-7832
Chek1	10916	-6645
Chek2	-5693	11236
Ckap5	-1941	9831
Clasp1	8043	-6017
Clasp2	14039	-9470
Clip1	-3196	-4018
Clspn	-4322	6551
Dbf4	11748	-11992
Dna2	-7971	5856
Dsn1	12989	-13118
Dync1h1	12037	3704
Dync1i1	7564	7503
Dync1i2	13930	-14334
Dync1li1	10870	-10085
Dync1li2	13775	-14349
Dynll1	-10023	-2241
Dynll2	-12351	10871
Ercc6l	-7435	2783
Exo1	11044	-10136
Fam175a	6799	4765
Gtse1	14189	5321
H2afx	-3852	6424
Herc2	-7744	11170
Hus1	-10726	1804
Incenp	5723	-3327
Itgb3bp	4897	-8304
Kat5	4420	6683
Kif18a	-3219	-3152
Kif2a	11818	-4454
Kif2c	10981	-8403
Kntc1	11653	-11626
Mad1l1	-2336	6065
Mad2l1	12617	-8263
Mapre1	3104	2535
Mcm10	3403	4685
Mcm2	-1041	10178
Mcm3	3215	4597
Mcm4	-1878	-3408
Mcm5	-4271	7491
Mcm6	5041	5685
Mcm7	6463	7251
Mcm8	11218	-4422
Mdc1	-4783	9438
Mdm2	15095	-7329
Mdm4	-4386	-13416
Mis12	-8150	7697
Mre11a	-5960	7726
Nbn	-7224	-4610
Ndc80	11305	-7543
Nde1	-6074	8864
Ndel1	-6462	-13712
Nsl1	2968	2930
Nudc	9181	-10432
Nuf2	8710	-9737
Nup107	-4524	-6225
Nup133	-6405	10731
Nup160	-7196	-7326
Nup37	-4813	9951
Nup43	8894	-8868
Nup85	-9207	9918
Nup98	10837	4406
Orc1	9734	-7991
Orc2	2889	-9894
Orc3	-4717	3382
Orc4	-5269	-2439
Orc5	10597	-8072
Orc6	374	-7010
Pafah1b1	4117	-10743
Pcbp4	-10989	12360
Phf20	12053	-14031
Pias4	-9679	8206
Pkmyt1	10003	-8959
Plk1	9395	-5777
Pmf1	13680	-10495
Ppp1cc	13589	-11988
Ppp2ca	2443	326
Ppp2cb	14291	-13381
Ppp2r1a	11507	3755
Ppp2r1b	-3062	-7202
Ppp2r5a	14617	-14818
Ppp2r5b	-2576	4479
Ppp2r5c	12442	-9365
Ppp2r5d	11554	1834
Ppp2r5e	-4849	4842
Psma1	-6738	-7608
Psma2	2844	-13370
Psma3	9490	-12548
Psma4	4617	-12505
Psma5	5504	-11202
Psma6	9985	-12478
Psma7	13781	-14022
Psma8	-7575	7041
Psmb1	6104	-12225
Psmb10	8202	-4783
Psmb11	5872	-6129
Psmb2	7847	-11836
Psmb3	12063	-13952
Psmb4	-4466	-8497
Psmb5	10041	-10541
Psmb6	11789	-12835
Psmb7	175	-13055
Psmb8	-5795	2962
Psmb9	-3858	5687
Psmc1	11705	-6393
Psmc2	-10211	7777
Psmc3	13783	-13466
Psmc4	-7487	10029
Psmc5	5939	-5097
Psmc6	-5320	-12074
Psmd1	-4486	-6816
Psmd10	-5266	7738
Psmd11	-4239	-7981
Psmd12	-5190	-6195
Psmd13	10924	-7634
Psmd14	-9498	2769
Psmd2	-11276	10253
Psmd3	5369	146
Psmd4	8666	-10398
Psmd5	-1595	-6026
Psmd6	-1663	-8390
Psmd7	-9175	-8611
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Psme2b	158	1873
Psme3	-3827	9126
Psme4	-4545	-7955
Psmf1	3006	8610
Rad1	-6955	4321
Rad17	226	-6799
Rad50	9654	-3235
Rad9a	8550	4566
Rad9b	6251	-7308
Ranbp2	-1884	-9227
Rangap1	-4113	2101
Rbbp8	13717	-12966
Rcc2	2405	7611
Rfc2	-6748	11476
Rfc3	13044	-6703
Rfc4	3874	2158
Rfc5	12334	8699
Rfwd2	-2988	-5509
Rhno1	7419	-5059
Rmi1	-9220	10169
Rmi2	9282	3955
Rnf168	-4091	-149
Rnf8	-2987	-6982
Rpa1	-5523	11078
Rpa2	6898	-2423
Rpa3	-2462	3353
Rps27	13829	-14647
Rps27a	13894	-14715
Sec13	9849	-12486
Seh1l	9415	-7505
Sfn	9301	71
Sgol1	-1679	7844
Sgol2a	8718	-3548
Ska1	6709	-10296
Ska2	-9526	7541
Spc24	13403	-11390
Spc25	15273	-15132
Spdl1	10773	-10080
Sumo1	-5337	-10745
Taok1	-4234	-10641
Top3a	-8478	-5110
Topbp1	4504	-5842
Trp53	-7681	5460
Trp53bp1	-9861	10372
Uba52	4596	-6796
Ubb	-3411	-7959
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037
Ube2v2	-8928	4163
Uimc1	-4365	352
Wee1	249	-14752
Wrn	-3128	5665
Xpo1	-10778	9680
Ywhab	-3531	-52
Ywhae	2275	-8018
Ywhag	-10205	10203
Ywhah	3055	-11126
Ywhaq	12431	-12558
Zfp385a	15036	-8764
Zw10	-5911	7531
Zwilch	13125	-12780
Zwint	12999	-14462

---

---

NRIF-signals-cell-death-from-the-nucleus

NRIF-signals-cell-death-from-the-nucleus

metric	value
setSize	15
pMANOVA	0.466
p.adjustMANOVA	0.65
s.dist	0.221
s.diab	0.122
s.PMX	-0.184
p.diab	0.413
p.PMX	0.217

Top 20 genes

Gene	diab	PMX
Rps27a	13894	-14715
Traf6	13741	-14203
Aph1b	13941	-13577
Ncstn	14410	-12169
Ngfr	10298	-6900
Psen2	7176	-5828
Itgb3bp	4897	-8304
Uba52	4596	-6796

Click HERE to show all gene set members

All member genes

	diab	PMX
Aph1a	-620	4686
Aph1b	13941	-13577
Itgb3bp	4897	-8304
Mapk8	86	2880
Ncstn	14410	-12169
Ngf	-6631	2748
Ngfr	10298	-6900
Psen1	-11531	9651
Psen2	7176	-5828
Psenen	-7498	6057
Rps27a	13894	-14715
Sqstm1	-7943	9582
Traf6	13741	-14203
Uba52	4596	-6796
Ubb	-3411	-7959

---

---

TP53-Regulates-Transcription-of-Cell-Cycle-Genes

TP53-Regulates-Transcription-of-Cell-Cycle-Genes

metric	value
setSize	46
pMANOVA	0.0469
p.adjustMANOVA	0.154
s.dist	0.217
s.diab	0.199
s.PMX	-0.0856
p.diab	0.0195
p.PMX	0.315

Top 20 genes

Gene	diab	PMX
Btg2	15122	-14014
Rgcc	14711	-13598
Plk3	14013	-14168
E2f1	14773	-13127
Cdkn1a	15394	-12557
Pcna	13367	-14114
Cdk2	12902	-12285
Tfdp2	12095	-12073
Zfp385a	15036	-8764
Cdk1	12509	-9455
Plagl1	14219	-8257
Ccnb1	14031	-8068
Aurka	12135	-7881
Ccne1	8507	-10924
Rbl2	11787	-7420
Ccna2	12043	-6678
Cnot6l	6231	-12283
Cdc25c	9859	-6321
Carm1	8621	-6979
Tnks1bp1	4119	-14130

Click HERE to show all gene set members

All member genes

	diab	PMX
Arid3a	-9238	8570
Aurka	12135	-7881
Bax	11957	8555
Btg2	15122	-14014
Carm1	8621	-6979
Ccna2	12043	-6678
Ccnb1	14031	-8068
Ccne1	8507	-10924
Ccne2	4837	-11061
Cdc25c	9859	-6321
Cdk1	12509	-9455
Cdk2	12902	-12285
Cdkn1a	15394	-12557
Cdkn1b	4380	258
Cenpj	-11728	6522
Cnot1	2862	4781
Cnot10	8561	1690
Cnot11	-131	2908
Cnot2	-6965	6675
Cnot3	-8690	6241
Cnot4	-7023	1964
Cnot6	-4378	2900
Cnot6l	6231	-12283
Cnot7	-8230	-5989
Cnot8	-10527	7261
E2f1	14773	-13127
E2f4	-8258	5909
E2f7	-6064	9808
E2f8	3208	5434
Ep300	-10091	9600
Gadd45a	2843	-9278
Pcbp4	-10989	12360
Pcna	13367	-14114
Plagl1	14219	-8257
Plk2	13531	11848
Plk3	14013	-14168
Prmt1	12405	-3165
Rbl1	-9375	11563
Rbl2	11787	-7420
Rgcc	14711	-13598
Sfn	9301	71
Tfdp1	-7152	7854
Tfdp2	12095	-12073
Tnks1bp1	4119	-14130
Trp53	-7681	5460
Zfp385a	15036	-8764

---

---

Sema4D-induced-cell-migration-and-growth-cone-collapse

Sema4D-induced-cell-migration-and-growth-cone-collapse

metric	value
setSize	19
pMANOVA	0.152
p.adjustMANOVA	0.292
s.dist	0.214
s.diab	0.211
s.PMX	-0.0374
p.diab	0.111
p.PMX	0.778

Top 20 genes

Gene	diab	PMX
Myl6	11221	-14108
Limk2	14475	-9474
Myl12b	10115	-13120
Rhob	9640	-12113
Rock2	7938	-13372
Myh14	10015	-8495
Rock1	4877	-11833
Plxnb1	11092	-4388
Myl9	9432	-4957
Arhgef11	9956	-369

Click HERE to show all gene set members

All member genes

	diab	PMX
Arhgef11	9956	-369
Arhgef12	-12030	10200
Erbb2	-310	-10575
Limk1	11390	3370
Limk2	14475	-9474
Myh10	9979	12027
Myh11	10080	12361
Myh14	10015	-8495
Myh9	-3199	2907
Myl12b	10115	-13120
Myl6	11221	-14108
Myl9	9432	-4957
Plxnb1	11092	-4388
Rhob	9640	-12113
Rhoc	-10110	8403
Rnd1	-10960	10295
Rock1	4877	-11833
Rock2	7938	-13372
Sema4d	-12323	13004

---

---

Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters

Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters

metric	value
setSize	20
pMANOVA	0.087
p.adjustMANOVA	0.2
s.dist	0.189
s.diab	0.03
s.PMX	0.186
p.diab	0.817
p.PMX	0.149

Top 20 genes

Gene	diab	PMX
Ap2a1	9324	5186

Click HERE to show all gene set members

All member genes

	diab	PMX
Ap1b1	13743	-84
Ap1g1	-5711	5760
Ap1m1	-8412	11386
Ap1m2	14596	-10523
Ap1s1	-4270	5668
Ap1s2	6287	-8915
Ap1s3	-6241	8053
Ap2a1	9324	5186
Ap2a2	-8561	11221
Ap2b1	-9075	10334
Ap2m1	11298	-6224
Ap2s1	11182	-5073
Arf1	-4458	-3277
Atp6v1h	9566	-8530
B2m	15002	-15005
Cd28	-8163	8355
Cd4	-2373	10589
Cd8b1	-4721	10118
Lck	-8490	10472
Pacs1	14041	-8312

---

---

MET-promotes-cell-motility

MET-promotes-cell-motility

metric	value
setSize	29
pMANOVA	0.23
p.adjustMANOVA	0.378
s.dist	0.186
s.diab	-0.0701
s.PMX	0.172
p.diab	0.513
p.PMX	0.109

Top 20 genes

Gene	diab	PMX
Met	-12780	12742
Lama4	-12738	12562
Tns3	-12632	12630
Lama2	-12274	12567
Lamc3	-12142	12570
Crkl	-11519	10889
Hgf	-12068	9941
Lamb1	-8857	11401
Lama1	-6518	12437
Lama3	-9254	7235
Rac1	-4047	262

Click HERE to show all gene set members

All member genes

	diab	PMX
Crk	-5870	-9136
Crkl	-11519	10889
Dock7	14759	-14157
Gab1	-9889	-8445
Grb2	8972	3406
Hgf	-12068	9941
Itga2	7236	-6041
Itga3	9099	6566
Itgb1	5869	-13098
Lama1	-6518	12437
Lama2	-12274	12567
Lama3	-9254	7235
Lama4	-12738	12562
Lama5	14788	-8076
Lamb1	-8857	11401
Lamb2	7606	8928
Lamb3	12930	-13656
Lamc1	13297	-9372
Lamc2	15047	-12749
Lamc3	-12142	12570
Met	-12780	12742
Ptk2	9305	2859
Rac1	-4047	262
Rap1a	-234	-12456
Rap1b	-1828	-11439
Rapgef1	6711	11910
Src	8646	4243
Tns3	-12632	12630
Tns4	7660	4798

---

---

Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)

Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)

metric	value
setSize	11
pMANOVA	0.747
p.adjustMANOVA	0.92
s.dist	0.152
s.diab	-0.0756
s.PMX	0.132
p.diab	0.664
p.PMX	0.45

Top 20 genes

Gene	diab	PMX
Ubn1	-10645	11079
Lmnb1	-9916	8126
Ep400	-6397	9291
Trp53	-7681	5460
Cabin1	-3241	8514
Hira	-2684	4510

Click HERE to show all gene set members

All member genes

	diab	PMX
Asf1a	-6271	-233
Cabin1	-3241	8514
Cdkn1a	15394	-12557
Ep400	-6397	9291
Hira	-2684	4510
Hmga1	14417	-11978
Hmga2	4574	275
Lmnb1	-9916	8126
Rb1	15102	-13818
Trp53	-7681	5460
Ubn1	-10645	11079

---

---

FOXO-mediated-transcription-of-cell-death-genes

FOXO-mediated-transcription-of-cell-death-genes

metric	value
setSize	15
pMANOVA	0.717
p.adjustMANOVA	0.92
s.dist	0.151
s.diab	-0.0907
s.PMX	0.121
p.diab	0.543
p.PMX	0.417

Top 20 genes

Gene	diab	PMX
Nfya	-12328	12716
Bcl6	-11275	12055
Pink1	-11162	11930
Ep300	-10091	9600
Nfyb	-7061	7045
Stk11	-4042	10593
Fasl	-3718	6336
Nfyc	-3343	5943
Foxo4	-4785	2785

Click HERE to show all gene set members

All member genes

	diab	PMX
Bcl2l11	10641	-10810
Bcl6	-11275	12055
Cited2	13876	-12832
Crebbp	7115	-7498
Ddit3	13910	-13026
Ep300	-10091	9600
Fasl	-3718	6336
Foxo1	8079	-10792
Foxo3	14625	-14429
Foxo4	-4785	2785
Nfya	-12328	12716
Nfyb	-7061	7045
Nfyc	-3343	5943
Pink1	-11162	11930
Stk11	-4042	10593

---

---

Cell-extracellular-matrix-interactions

Cell-extracellular-matrix-interactions

metric	value
setSize	16
pMANOVA	0.204
p.adjustMANOVA	0.361
s.dist	0.15
s.diab	-0.132
s.PMX	-0.0703
p.diab	0.359
p.PMX	0.627

Top 20 genes

Gene	diab	PMX
Fermt2	-6317	-9249
Parvb	-6686	-4411
Actn1	-2955	-9395
Fblim1	-2605	-9339
Rsu1	-7576	-2947
Ilk	-313	-495

Click HERE to show all gene set members

All member genes

	diab	PMX
Actn1	-2955	-9395
Arhgef6	10050	5932
Fblim1	-2605	-9339
Fermt2	-6317	-9249
Flna	-8364	9099
Flnc	5925	-12857
Ilk	-313	-495
Itgb1	5869	-13098
Lims1	-8618	3597
Lims2	-11479	10148
Parva	14174	-13205
Parvb	-6686	-4411
Pxn	5824	-177
Rsu1	-7576	-2947
Tesk1	7984	9088
Vasp	-3832	4449

---

---

Assembly-and-cell-surface-presentation-of-NMDA-receptors

Assembly-and-cell-surface-presentation-of-NMDA-receptors

metric	value
setSize	25
pMANOVA	0.0983
p.adjustMANOVA	0.215
s.dist	0.143
s.diab	0.122
s.PMX	0.0746
p.diab	0.291
p.PMX	0.518

Top 20 genes

Gene	diab	PMX
Nefl	14459	9119
Nbea	11248	7890
Dlg3	9912	3835
Lin7b	8739	3638
Grin1	8164	3365

Click HERE to show all gene set members

All member genes

	diab	PMX
Actn2	13375	-10971
Apba1	-6642	5916
Camk2a	-8582	9297
Camk2b	12864	-14402
Camk2d	14624	-13868
Camk2g	-9180	8979
Cask	13958	-14155
Dlg1	12024	-11729
Dlg2	-8800	12793
Dlg3	9912	3835
Dlg4	-7223	10585
Grin1	8164	3365
Grin2a	8133	-4772
Grin2b	7538	-7715
Grin2c	-8070	8860
Grin2d	4321	-10284
Grin3a	-10410	11126
Grin3b	-11710	11922
Kif17	7565	-426
Lin7a	-12341	7926
Lin7b	8739	3638
Lin7c	-616	-14468
Lrrc7	12248	-12822
Nbea	11248	7890
Nefl	14459	9119

---

---

Cell-Cycle,-Mitotic

Cell-Cycle,-Mitotic

metric	value
setSize	479
pMANOVA	9.44e-05
p.adjustMANOVA	0.000724
s.dist	0.142
s.diab	0.114
s.PMX	-0.0849
p.diab	1.78e-05
p.PMX	0.00141

Top 20 genes

Gene	diab	PMX
Ccnd3	15351	-15060
Spc25	15273	-15132
Chmp4c	14654	-14956
Ppp2r5a	14617	-14818
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rb1	15102	-13818
Optn	15124	-13664
Cdkn2b	14383	-14293
Rps27a	13894	-14715
Rps27	13829	-14647
Nek6	13921	-14431
Dync1i2	13930	-14334
Dync1li2	13775	-14349
Golga2	14538	-13457
E2f1	14773	-13127
Cdkn1a	15394	-12557
Psma7	13781	-14022
Ube2i	13984	-13775

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Abl1	6603.0	-4424.0
Actr1a	10383.0	-8216.0
Ahctf1	-10865.0	-10185.0
Ajuba	-11055.0	10965.0
Akap9	5910.0	-8203.0
Akt1	11899.0	-4407.0
Akt2	-10282.0	10289.0
Akt3	-23.0	-6307.0
Alms1	-11955.0	12031.0
Anapc1	-11278.0	10450.0
Anapc10	-40.0	-7692.0
Anapc11	-4767.0	-2276.0
Anapc15	-2513.0	-9553.0
Anapc16	13128.0	-13447.0
Anapc2	-3217.0	9388.0
Anapc4	14276.0	-12248.0
Anapc5	14536.0	-12088.0
Anapc7	10824.0	-6183.0
Ankle2	2982.0	3698.0
Arpp19	-10703.0	11233.0
Aurka	12135.0	-7881.0
Aurkb	6296.0	-7654.0
B9d2	-5649.0	8837.0
Banf1	9290.0	-8382.0
Birc5	12522.0	-11275.0
Blzf1	7887.0	-3336.0
Bmyc	6106.0	3479.0
Bora	10161.0	-12351.0
Btrc	-1383.0	8479.0
Bub1	7301.0	7957.0
Bub1b	11232.0	4229.0
Bub3	-11165.0	11759.0
Cables1	2270.0	12575.0
Cc2d1b	8641.0	7466.0
Ccna2	12043.0	-6678.0
Ccnb1	14031.0	-8068.0
Ccnb2	10799.0	-9616.0
Ccnd1	10280.0	12715.0
Ccnd2	-10391.0	11271.0
Ccnd3	15351.0	-15060.0
Ccne1	8507.0	-10924.0
Ccne2	4837.0	-11061.0
Ccnh	-9565.0	9010.0
Ccp110	-3885.0	-8946.0
Cdc14a	-8389.0	10394.0
Cdc16	10625.0	-286.0
Cdc20	13126.0	-4714.0
Cdc23	180.0	8382.0
Cdc25a	3462.0	-12613.0
Cdc25b	8473.0	6982.0
Cdc25c	9859.0	-6321.0
Cdc26	8205.0	-5823.0
Cdc27	-6730.0	-6274.0
Cdc45	8657.0	-7688.0
Cdc6	-2324.0	4582.0
Cdc7	-9107.0	8769.0
Cdca5	6525.0	30.0
Cdca8	3238.0	-2833.0
Cdk1	12509.0	-9455.0
Cdk11b	10589.0	-10741.0
Cdk2	12902.0	-12285.0
Cdk4	7497.0	6438.0
Cdk5rap2	-7137.0	3897.0
Cdk6	-8022.0	-8784.0
Cdk7	-6948.0	4688.0
Cdkn1a	15394.0	-12557.0
Cdkn1b	4380.0	258.0
Cdkn1c	11412.0	12041.0
Cdkn2b	14383.0	-14293.0
Cdkn2c	-1158.0	9132.0
Cdkn2d	5293.0	2129.0
Cdt1	8222.0	-9768.0
Cenpa	3435.0	5318.0
Cenpc1	-3272.0	-8022.0
Cenpe	4365.0	-6647.0
Cenpf	13427.0	-379.0
Cenph	10433.0	-9250.0
Cenpi	8123.0	-7481.0
Cenpj	-11728.0	6522.0
Cenpk	9317.0	-8016.0
Cenpl	-1784.0	-10457.0
Cenpm	11559.0	-9488.0
Cenpn	9068.0	4694.0
Cenpo	4588.0	-8699.0
Cenpp	5610.0	4078.0
Cenpq	-8830.0	-3341.0
Cenpt	13110.0	-10179.0
Cenpu	11737.0	-7832.0
Cep131	11325.0	-5598.0
Cep135	-3810.0	8621.0
Cep152	-1773.0	196.0
Cep164	8128.0	5691.0
Cep192	52.0	8736.0
Cep250	-3793.0	9525.0
Cep290	-10441.0	11686.0
Cep41	-10073.0	11800.0
Cep57	8021.0	-13087.0
Cep63	-3404.0	-10352.0
Cep70	12768.0	392.0
Cep72	8804.0	5042.0
Cep76	-5040.0	5787.0
Cep78	-9622.0	4307.0
Cetn2	-9237.0	3491.0
Chmp2a	6531.0	-8482.0
Chmp2b	11049.0	-9912.0
Chmp3	8777.0	-13102.0
Chmp4b	13369.0	-13601.0
Chmp4c	14654.0	-14956.0
Chmp6	9126.0	9611.0
Chmp7	-7612.0	12648.0
Ckap5	-1941.0	9831.0
Cks1b	12264.0	-6528.0
Clasp1	8043.0	-6017.0
Clasp2	14039.0	-9470.0
Clip1	-3196.0	-4018.0
Cnep1r1	4530.0	-11794.0
Cntrl	10308.0	-9086.0
Csnk1d	4297.0	-10796.0
Csnk1e	10966.0	-7406.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Ctdnep1	-10262.0	11004.0
Cul1	114.0	-11623.0
Dbf4	11748.0	-11992.0
Dctn1	4613.0	8656.0
Dctn2	13574.0	-8129.0
Dctn3	13985.0	-13682.0
Dhfr	-11741.0	10911.0
Dna2	-7971.0	5856.0
Dsn1	12989.0	-13118.0
Dync1h1	12037.0	3704.0
Dync1i1	7564.0	7503.0
Dync1i2	13930.0	-14334.0
Dync1li1	10870.0	-10085.0
Dync1li2	13775.0	-14349.0
Dynll1	-10023.0	-2241.0
Dynll2	-12351.0	10871.0
Dyrk1a	6379.0	-5909.0
E2f1	14773.0	-13127.0
E2f2	-10922.0	8773.0
E2f3	9873.0	3869.0
E2f4	-8258.0	5909.0
E2f5	-12272.0	11795.0
E2f6	-11558.0	12122.0
Emd	9167.0	-10589.0
Eml4	398.0	4690.0
Ensa	4482.0	-12626.0
Ep300	-10091.0	9600.0
Ercc6l	-7435.0	2783.0
Esco1	-6644.0	1090.0
Esco2	11918.0	-9481.0
Espl1	7494.0	-361.0
Fbxl18	-8136.0	9051.0
Fbxl7	-276.0	7460.0
Fbxo5	-1870.0	5491.0
Fbxw11	-10435.0	9702.0
Fen1	7543.0	234.0
Fkbpl	-5916.0	4598.0
Foxm1	12715.0	-5772.0
Fzr1	-2715.0	9851.0
Gins1	-4499.0	1259.0
Gins2	14037.0	-12388.0
Gins3	-2737.0	-3111.0
Gins4	6658.0	-4395.0
Gmnn	12869.0	-13700.0
Golga2	14538.0	-13457.0
Gorasp1	-11150.0	12579.0
Gorasp2	2975.0	3355.0
Gsk3b	-6315.0	7700.0
Gtse1	14189.0	5321.0
H2afx	-3852.0	6424.0
Haus1	9580.0	-4996.0
Haus2	-1376.0	-9517.0
Haus3	12682.0	-12876.0
Haus4	13772.0	-8411.0
Haus5	3099.0	5247.0
Haus6	-4075.0	-11789.0
Haus7	14036.0	-9664.0
Haus8	9204.0	3914.0
Hdac1	-10878.0	10117.0
Hdac8	5664.0	-6069.0
Hmmr	13358.0	-11832.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Incenp	5723.0	-3327.0
Ist1	8650.0	5536.0
Itgb3bp	4897.0	-8304.0
Jak2	-8549.0	-13401.0
Kif18a	-3219.0	-3152.0
Kif20a	13428.0	-4447.0
Kif23	14225.0	-12979.0
Kif2a	11818.0	-4454.0
Kif2c	10981.0	-8403.0
Kmt5a	5653.0	6397.0
Kntc1	11653.0	-11626.0
Kpnb1	10908.0	1199.0
Lbr	-12455.0	12869.0
Lcmt1	13397.0	-7684.0
Lemd2	4754.0	6810.0
Lemd3	2945.0	-5014.0
Lig1	13161.0	-4756.0
Lin37	-7391.0	6267.0
Lin52	9562.0	-7056.0
Lin54	-5778.0	5287.0
Lin9	7699.0	-11842.0
Lmna	5606.0	3857.0
Lmnb1	-9916.0	8126.0
Lpin1	13638.0	-14073.0
Lpin2	12674.0	-14612.0
Lpin3	14358.0	-8350.0
Lyn	-7639.0	6.0
Mad1l1	-2336.0	6065.0
Mad2l1	12617.0	-8263.0
Mapk1	6867.0	-10406.0
Mapk3	10588.0	-6813.0
Mapre1	3104.0	2535.0
Mastl	9321.0	-5732.0
Mau2	13230.0	-13597.0
Max	13684.0	-12344.0
Mcm10	3403.0	4685.0
Mcm2	-1041.0	10178.0
Mcm3	3215.0	4597.0
Mcm4	-1878.0	-3408.0
Mcm5	-4271.0	7491.0
Mcm6	5041.0	5685.0
Mcm7	6463.0	7251.0
Mcm8	11218.0	-4422.0
Mcph1	8663.0	-388.0
Mis12	-8150.0	7697.0
Mnat1	5792.0	4333.0
Mybl2	11695.0	-13356.0
Mzt1	10494.0	-12063.0
Mzt2	10538.0	-7815.0
Ncapd2	10711.0	-105.0
Ncapd3	11681.0	-13198.0
Ncapg	8006.0	5170.0
Ncapg2	13407.0	-8517.0
Ncaph	9662.0	-7763.0
Ncaph2	4224.0	91.0
Ndc1	13238.0	-12109.0
Ndc80	11305.0	-7543.0
Nde1	-6074.0	8864.0
Ndel1	-6462.0	-13712.0
Nedd1	-5802.0	-9203.0
Nek2	14119.0	-11365.0
Nek6	13921.0	-14431.0
Nek7	-8839.0	7258.0
Nek9	-8705.0	11327.0
Ninl	12966.0	-10855.0
Nipbl	-7169.0	-3159.0
Nme7	-10054.0	6679.0
Nsl1	2968.0	2930.0
Nudc	9181.0	-10432.0
Nuf2	8710.0	-9737.0
Numa1	-6029.0	10210.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Odf2	12329.0	-8688.0
Ofd1	12344.0	-10416.0
Optn	15124.0	-13664.0
Orc1	9734.0	-7991.0
Orc2	2889.0	-9894.0
Orc3	-4717.0	3382.0
Orc4	-5269.0	-2439.0
Orc5	10597.0	-8072.0
Orc6	374.0	-7010.0
Pafah1b1	4117.0	-10743.0
Pcm1	11605.0	-13363.0
Pcna	13367.0	-14114.0
Pcnt	11489.0	-8081.0
Pds5a	-2274.0	-8133.0
Pds5b	-8117.0	11104.0
Phf8	-1381.0	-4659.0
Phlda1	-8040.0	9959.0
Pkmyt1	10003.0	-8959.0
Plk1	9395.0	-5777.0
Plk4	2268.0	-7402.0
Pmf1	13680.0	-10495.0
Pola1	-8880.0	5777.0
Pola2	8004.0	-5681.0
Pold1	5255.0	4543.0
Pold2	12631.0	-8485.0
Pold3	-4233.0	6741.0
Pold4	7034.0	-12051.0
Pole	11606.0	-7660.0
Pole2	-7143.0	-143.0
Pole3	10431.0	-13031.0
Pole4	-11603.0	7992.0
Pom121	9659.0	-12785.0
Ppme1	3702.0	3.0
Ppp1cb	4565.0	-10643.0
Ppp1cc	13589.0	-11988.0
Ppp1r12a	3470.0	-9878.0
Ppp1r12b	-7715.0	11767.0
Ppp2ca	2443.0	326.0
Ppp2cb	14291.0	-13381.0
Ppp2r1a	11507.0	3755.0
Ppp2r1b	-3062.0	-7202.0
Ppp2r2a	-1142.0	-9444.0
Ppp2r2d	12749.0	-14570.0
Ppp2r3d	-3033.0	6807.0
Ppp2r5a	14617.0	-14818.0
Ppp2r5b	-2576.0	4479.0
Ppp2r5c	12442.0	-9365.0
Ppp2r5d	11554.0	1834.0
Ppp2r5e	-4849.0	4842.0
Prim1	-8624.0	10425.0
Prim2	-9097.0	5742.0
Prkar2b	-11024.0	2146.0
Prkca	-11577.0	11021.0
Prkcb	-7742.0	7077.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptk6	-8916.0	7487.0
Pttg1	13199.0	-11759.0
Rab1a	-8474.0	2511.0
Rab1b	-6847.0	3621.0
Rab2a	-8200.0	-6726.0
Rab8a	-7413.0	-3395.0
Rad21	-6091.0	-9748.0
Rae1	-2818.0	7959.0
Ran	-340.0	-458.0
Ranbp2	-1884.0	-9227.0
Rangap1	-4113.0	2101.0
Rb1	15102.0	-13818.0
Rbbp4	-12462.0	12126.0
Rbl1	-9375.0	11563.0
Rbl2	11787.0	-7420.0
Rbx1	2286.0	4532.0
Rcc1	-11744.0	12735.0
Rcc2	2405.0	7611.0
Rfc1	9267.0	-10537.0
Rfc2	-6748.0	11476.0
Rfc3	13044.0	-6703.0
Rfc4	3874.0	2158.0
Rfc5	12334.0	8699.0
Rpa1	-5523.0	11078.0
Rpa2	6898.0	-2423.0
Rpa3	-2462.0	3353.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rrm2	14293.0	-13094.0
Sdccag8	10406.0	-11798.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Set	-7029.0	5919.0
Sfi1	-8788.0	8246.0
Sgol1	-1679.0	7844.0
Sgol2a	8718.0	-3548.0
Sirt2	9215.0	-457.0
Ska1	6709.0	-10296.0
Ska2	-9526.0	7541.0
Skp1a	-9392.0	1413.0
Skp2	-9937.0	5846.0
Smc1a	3009.0	-11954.0
Smc2	194.0	-3587.0
Smc3	9972.0	-12948.0
Smc4	-3258.0	-8259.0
Spast	-7791.0	2757.0
Spc24	13403.0	-11390.0
Spc25	15273.0	-15132.0
Spdl1	10773.0	-10080.0
Src	8646.0	4243.0
Ssna1	-6691.0	-6655.0
Stag1	-9666.0	10304.0
Stag2	2947.0	-13895.0
Sumo1	-5337.0	-10745.0
Taok1	-4234.0	-10641.0
Tfdp1	-7152.0	7854.0
Tfdp2	12095.0	-12073.0
Tk1	-11584.0	10053.0
Tmpo	-11972.0	12265.0
Tnpo1	9194.0	-10888.0
Top2a	11131.0	-17.0
Tpr	-7568.0	-3358.0
Tpx2	12040.0	4167.0
Trp53	-7681.0	5460.0
Tuba1a	-2804.0	-5493.0
Tuba1b	6722.0	5365.0
Tuba4a	-4434.0	8186.0
Tuba8	12324.0	-4975.0
Tubal3	876.5	-1222.5
Tubb1	-3307.0	-456.0
Tubb2a	11648.0	-11653.0
Tubb2b	14029.0	-12592.0
Tubb3	-1623.0	4178.0
Tubb4a	4305.0	7032.0
Tubb4b	-7669.0	7704.0
Tubb5	4901.0	-6793.0
Tubb6	-9629.0	9882.0
Tubg1	6654.0	8230.0
Tubg2	7002.0	2507.0
Tubgcp2	12709.0	9053.0
Tubgcp3	10323.0	-8943.0
Tubgcp4	-10450.0	8640.0
Tubgcp5	3415.0	-10011.0
Tubgcp6	-10196.0	8388.0
Tyms	7851.0	-10098.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2c	9861.0	-8024.0
Ube2d1	11721.0	-13291.0
Ube2e1	-10811.0	7252.0
Ube2i	13984.0	-13775.0
Ube2s	9693.0	-6037.0
Uso1	-8372.0	5238.0
Vps4a	-10273.0	7118.0
Vrk1	-3620.0	7646.0
Vrk2	-4483.0	1847.0
Wapl	-3476.0	-10206.0
Wee1	249.0	-14752.0
Xpo1	-10778.0	9680.0
Ywhae	2275.0	-8018.0
Ywhag	-10205.0	10203.0
Zw10	-5911.0	7531.0
Zwilch	13125.0	-12780.0
Zwint	12999.0	-14462.0

---

---

Cell-junction-organization

Cell-junction-organization

metric	value
setSize	78
pMANOVA	0.217
p.adjustMANOVA	0.369
s.dist	0.141
s.diab	0.114
s.PMX	-0.083
p.diab	0.0808
p.PMX	0.205

Top 20 genes

Gene	diab	PMX
Nectin1	15040	-14466
Cdh6	14279	-14377
Cldn19	14026	-14397
Cldn3	13399	-14457
Lamc2	15047	-12749
Parva	14174	-13205
Itgb4	14708	-12358
Nectin2	14700	-12326
Lamb3	12930	-13656
Cldn4	14680	-11852
Cldn15	14862	-11517
Cd151	12960	-12761
Col17a1	13341	-11901
Dst	12167	-12864
Cdh4	12570	-12281
F11r	11089	-13222
Cdh3	14386	-9982
Pvr	12149	-11086
Cldn7	13810	-9723
Cldn23	10399	-12378

Click HERE to show all gene set members

All member genes

	diab	PMX
Actn1	-2955.0	-9395.0
Arhgef6	10050.0	5932.0
Cadm1	-12680.0	12287.0
Cadm2	-7082.0	12271.0
Cadm3	4497.0	5204.0
Cd151	12960.0	-12761.0
Cdh1	-174.0	12292.0
Cdh10	-3437.0	7052.5
Cdh11	-9468.0	12564.0
Cdh13	-11949.0	12201.0
Cdh17	4740.0	-8372.0
Cdh2	-12474.0	5089.0
Cdh24	-3952.0	8158.0
Cdh3	14386.0	-9982.0
Cdh4	12570.0	-12281.0
Cdh5	-9073.0	12582.0
Cdh6	14279.0	-14377.0
Cdh8	1803.5	-2073.5
Cldn1	12954.0	2518.0
Cldn10	-12555.0	9350.0
Cldn11	11784.0	-9936.0
Cldn12	-10344.0	-6381.0
Cldn14	13725.0	-8003.0
Cldn15	14862.0	-11517.0
Cldn16	-7272.0	7202.0
Cldn17	-5763.0	1333.0
Cldn18	-11451.0	9869.0
Cldn19	14026.0	-14397.0
Cldn2	7747.0	-14483.0
Cldn20	-119.0	-6513.0
Cldn23	10399.0	-12378.0
Cldn3	13399.0	-14457.0
Cldn4	14680.0	-11852.0
Cldn5	-4673.0	11618.0
Cldn6	-8284.0	5503.0
Cldn7	13810.0	-9723.0
Cldn8	13832.0	3064.0
Cldn9	-6452.0	-4993.0
Col17a1	13341.0	-11901.0
Crb3	11061.0	5579.0
Ctnna1	5895.0	2751.0
Ctnnb1	-12039.0	12412.0
Dst	12167.0	-12864.0
F11r	11089.0	-13222.0
Fblim1	-2605.0	-9339.0
Fermt2	-6317.0	-9249.0
Flna	-8364.0	9099.0
Flnc	5925.0	-12857.0
Ilk	-313.0	-495.0
Itga6	10749.0	-2876.0
Itgb1	5869.0	-13098.0
Itgb4	14708.0	-12358.0
Jup	-4725.0	9124.0
Lama3	-9254.0	7235.0
Lamb3	12930.0	-13656.0
Lamc2	15047.0	-12749.0
Lims1	-8618.0	3597.0
Lims2	-11479.0	10148.0
Mpp5	-10314.0	-13200.0
Nectin1	15040.0	-14466.0
Nectin2	14700.0	-12326.0
Nectin3	-11266.0	9186.0
Nectin4	10771.0	7852.0
Pard3	-7793.0	-5508.0
Pard6a	2407.0	-8357.0
Pard6b	-34.0	10283.0
Pard6g	11905.0	6083.0
Parva	14174.0	-13205.0
Parvb	-6686.0	-4411.0
Plec	11898.0	-8539.0
Prkci	7391.0	-10491.0
Pvr	12149.0	-11086.0
Pxn	5824.0	-177.0
Rsu1	-7576.0	-2947.0
Sdk1	14935.0	-6001.0
Sdk2	14079.0	-7766.0
Tesk1	7984.0	9088.0
Vasp	-3832.0	4449.0

---

---

Cell-Cycle

Cell-Cycle

metric	value
setSize	603
pMANOVA	0.000123
p.adjustMANOVA	0.000811
s.dist	0.123
s.diab	0.101
s.PMX	-0.071
p.diab	2.22e-05
p.PMX	0.00283

Top 20 genes

Gene	diab	PMX
Ccnd3	15351	-15060
Spc25	15273	-15132
Nop10	14932	-15027
Chmp4c	14654	-14956
Ppp2r5a	14617	-14818
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rb1	15102	-13818
Brca1	14765	-14101
Optn	15124	-13664
Cdkn2b	14383	-14293
Rps27a	13894	-14715
Rps27	13829	-14647
Nek6	13921	-14431
Dync1i2	13930	-14334
Dync1li2	13775	-14349
Sun2	14577	-13431
Golga2	14538	-13457
Rsf1	13831	-14144

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Abl1	6603.0	-4424.0
Acd	-4896.0	9107.0
Actr1a	10383.0	-8216.0
Ahctf1	-10865.0	-10185.0
Ajuba	-11055.0	10965.0
Akap9	5910.0	-8203.0
Akt1	11899.0	-4407.0
Akt2	-10282.0	10289.0
Akt3	-23.0	-6307.0
Alms1	-11955.0	12031.0
Anapc1	-11278.0	10450.0
Anapc10	-40.0	-7692.0
Anapc11	-4767.0	-2276.0
Anapc15	-2513.0	-9553.0
Anapc16	13128.0	-13447.0
Anapc2	-3217.0	9388.0
Anapc4	14276.0	-12248.0
Anapc5	14536.0	-12088.0
Anapc7	10824.0	-6183.0
Ankle2	2982.0	3698.0
Ankrd28	13265.0	-13915.0
Arpp19	-10703.0	11233.0
Atm	11462.0	2585.0
Atr	4265.0	-9369.0
Atrip	8548.0	-28.0
Atrx	11763.0	-12296.0
Aurka	12135.0	-7881.0
Aurkb	6296.0	-7654.0
B9d2	-5649.0	8837.0
Babam1	-5669.0	6529.0
Banf1	9290.0	-8382.0
Bard1	7141.0	-328.0
Birc5	12522.0	-11275.0
Blm	13734.0	-11646.0
Blzf1	7887.0	-3336.0
Bmyc	6106.0	3479.0
Bora	10161.0	-12351.0
Brca1	14765.0	-14101.0
Brca2	12113.0	-14047.0
Brcc3	3410.0	-9434.0
Bre	14292.0	-12007.0
Brip1	12955.0	-13168.0
Btrc	-1383.0	8479.0
Bub1	7301.0	7957.0
Bub1b	11232.0	4229.0
Bub3	-11165.0	11759.0
Cables1	2270.0	12575.0
Cc2d1b	8641.0	7466.0
Ccna2	12043.0	-6678.0
Ccnb1	14031.0	-8068.0
Ccnb2	10799.0	-9616.0
Ccnd1	10280.0	12715.0
Ccnd2	-10391.0	11271.0
Ccnd3	15351.0	-15060.0
Ccne1	8507.0	-10924.0
Ccne2	4837.0	-11061.0
Ccnh	-9565.0	9010.0
Ccp110	-3885.0	-8946.0
Cdc14a	-8389.0	10394.0
Cdc16	10625.0	-286.0
Cdc20	13126.0	-4714.0
Cdc23	180.0	8382.0
Cdc25a	3462.0	-12613.0
Cdc25b	8473.0	6982.0
Cdc25c	9859.0	-6321.0
Cdc26	8205.0	-5823.0
Cdc27	-6730.0	-6274.0
Cdc45	8657.0	-7688.0
Cdc6	-2324.0	4582.0
Cdc7	-9107.0	8769.0
Cdca5	6525.0	30.0
Cdca8	3238.0	-2833.0
Cdk1	12509.0	-9455.0
Cdk11b	10589.0	-10741.0
Cdk2	12902.0	-12285.0
Cdk4	7497.0	6438.0
Cdk5rap2	-7137.0	3897.0
Cdk6	-8022.0	-8784.0
Cdk7	-6948.0	4688.0
Cdkn1a	15394.0	-12557.0
Cdkn1b	4380.0	258.0
Cdkn1c	11412.0	12041.0
Cdkn2b	14383.0	-14293.0
Cdkn2c	-1158.0	9132.0
Cdkn2d	5293.0	2129.0
Cdt1	8222.0	-9768.0
Cenpa	3435.0	5318.0
Cenpc1	-3272.0	-8022.0
Cenpe	4365.0	-6647.0
Cenpf	13427.0	-379.0
Cenph	10433.0	-9250.0
Cenpi	8123.0	-7481.0
Cenpj	-11728.0	6522.0
Cenpk	9317.0	-8016.0
Cenpl	-1784.0	-10457.0
Cenpm	11559.0	-9488.0
Cenpn	9068.0	4694.0
Cenpo	4588.0	-8699.0
Cenpp	5610.0	4078.0
Cenpq	-8830.0	-3341.0
Cenpt	13110.0	-10179.0
Cenpu	11737.0	-7832.0
Cenpw	10269.0	-7741.0
Cep131	11325.0	-5598.0
Cep135	-3810.0	8621.0
Cep152	-1773.0	196.0
Cep164	8128.0	5691.0
Cep192	52.0	8736.0
Cep250	-3793.0	9525.0
Cep290	-10441.0	11686.0
Cep41	-10073.0	11800.0
Cep57	8021.0	-13087.0
Cep63	-3404.0	-10352.0
Cep70	12768.0	392.0
Cep72	8804.0	5042.0
Cep76	-5040.0	5787.0
Cep78	-9622.0	4307.0
Cetn2	-9237.0	3491.0
Chek1	10916.0	-6645.0
Chek2	-5693.0	11236.0
Chmp2a	6531.0	-8482.0
Chmp2b	11049.0	-9912.0
Chmp3	8777.0	-13102.0
Chmp4b	13369.0	-13601.0
Chmp4c	14654.0	-14956.0
Chmp6	9126.0	9611.0
Chmp7	-7612.0	12648.0
Chtf18	-999.0	5623.0
Chtf8	-11988.0	12646.0
Ckap5	-1941.0	9831.0
Cks1b	12264.0	-6528.0
Clasp1	8043.0	-6017.0
Clasp2	14039.0	-9470.0
Clip1	-3196.0	-4018.0
Clspn	-4322.0	6551.0
Cnep1r1	4530.0	-11794.0
Cntrl	10308.0	-9086.0
Csnk1d	4297.0	-10796.0
Csnk1e	10966.0	-7406.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Ctc1	8890.0	4858.0
Ctdnep1	-10262.0	11004.0
Cul1	114.0	-11623.0
Daxx	-6696.0	7271.0
Dbf4	11748.0	-11992.0
Dctn1	4613.0	8656.0
Dctn2	13574.0	-8129.0
Dctn3	13985.0	-13682.0
Dhfr	-11741.0	10911.0
Dido1	-9774.0	-9656.0
Dkc1	-9010.0	7070.0
Dmc1	10141.0	1641.0
Dna2	-7971.0	5856.0
Dscc1	9583.0	-5359.0
Dsn1	12989.0	-13118.0
Dync1h1	12037.0	3704.0
Dync1i1	7564.0	7503.0
Dync1i2	13930.0	-14334.0
Dync1li1	10870.0	-10085.0
Dync1li2	13775.0	-14349.0
Dynll1	-10023.0	-2241.0
Dynll2	-12351.0	10871.0
Dyrk1a	6379.0	-5909.0
E2f1	14773.0	-13127.0
E2f2	-10922.0	8773.0
E2f3	9873.0	3869.0
E2f4	-8258.0	5909.0
E2f5	-12272.0	11795.0
E2f6	-11558.0	12122.0
Emd	9167.0	-10589.0
Eml4	398.0	4690.0
Ensa	4482.0	-12626.0
Ep300	-10091.0	9600.0
Ercc6l	-7435.0	2783.0
Esco1	-6644.0	1090.0
Esco2	11918.0	-9481.0
Espl1	7494.0	-361.0
Exo1	11044.0	-10136.0
Fam175a	6799.0	4765.0
Fbxl18	-8136.0	9051.0
Fbxl7	-276.0	7460.0
Fbxo5	-1870.0	5491.0
Fbxw11	-10435.0	9702.0
Fen1	7543.0	234.0
Fkbp6	4694.5	-4905.0
Fkbpl	-5916.0	4598.0
Foxm1	12715.0	-5772.0
Fzr1	-2715.0	9851.0
Gar1	-5704.0	-2440.0
Gins1	-4499.0	1259.0
Gins2	14037.0	-12388.0
Gins3	-2737.0	-3111.0
Gins4	6658.0	-4395.0
Gmnn	12869.0	-13700.0
Golga2	14538.0	-13457.0
Gorasp1	-11150.0	12579.0
Gorasp2	2975.0	3355.0
Gsk3b	-6315.0	7700.0
Gtse1	14189.0	5321.0
H2afx	-3852.0	6424.0
Haus1	9580.0	-4996.0
Haus2	-1376.0	-9517.0
Haus3	12682.0	-12876.0
Haus4	13772.0	-8411.0
Haus5	3099.0	5247.0
Haus6	-4075.0	-11789.0
Haus7	14036.0	-9664.0
Haus8	9204.0	3914.0
Hdac1	-10878.0	10117.0
Hdac8	5664.0	-6069.0
Herc2	-7744.0	11170.0
Hjurp	-9582.0	11276.0
Hmmr	13358.0	-11832.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Hspa2	14737.0	-9848.0
Hus1	-10726.0	1804.0
Incenp	5723.0	-3327.0
Ist1	8650.0	5536.0
Itgb3bp	4897.0	-8304.0
Jak2	-8549.0	-13401.0
Kat5	4420.0	6683.0
Kif18a	-3219.0	-3152.0
Kif20a	13428.0	-4447.0
Kif23	14225.0	-12979.0
Kif2a	11818.0	-4454.0
Kif2c	10981.0	-8403.0
Kmt5a	5653.0	6397.0
Kntc1	11653.0	-11626.0
Kpnb1	10908.0	1199.0
Lbr	-12455.0	12869.0
Lcmt1	13397.0	-7684.0
Lemd2	4754.0	6810.0
Lemd3	2945.0	-5014.0
Lig1	13161.0	-4756.0
Lin37	-7391.0	6267.0
Lin52	9562.0	-7056.0
Lin54	-5778.0	5287.0
Lin9	7699.0	-11842.0
Lmna	5606.0	3857.0
Lmnb1	-9916.0	8126.0
Lpin1	13638.0	-14073.0
Lpin2	12674.0	-14612.0
Lpin3	14358.0	-8350.0
Lyn	-7639.0	6.0
Mad1l1	-2336.0	6065.0
Mad2l1	12617.0	-8263.0
Mapk1	6867.0	-10406.0
Mapk3	10588.0	-6813.0
Mapre1	3104.0	2535.0
Mastl	9321.0	-5732.0
Mau2	13230.0	-13597.0
Max	13684.0	-12344.0
Mcm10	3403.0	4685.0
Mcm2	-1041.0	10178.0
Mcm3	3215.0	4597.0
Mcm4	-1878.0	-3408.0
Mcm5	-4271.0	7491.0
Mcm6	5041.0	5685.0
Mcm7	6463.0	7251.0
Mcm8	11218.0	-4422.0
Mcph1	8663.0	-388.0
Mdc1	-4783.0	9438.0
Mdm2	15095.0	-7329.0
Mdm4	-4386.0	-13416.0
Mis12	-8150.0	7697.0
Mis18a	5424.0	-6523.0
Mis18bp1	10046.0	-3755.0
Mlh1	-6045.0	6377.0
Mlh3	-10415.0	11077.0
Mnat1	5792.0	4333.0
Mnd1	-10696.0	5540.0
Mre11a	-5960.0	7726.0
Msh4	11993.0	-8386.0
Msh5	12959.0	-11537.0
Mybl2	11695.0	-13356.0
Mzt1	10494.0	-12063.0
Mzt2	10538.0	-7815.0
Nbn	-7224.0	-4610.0
Ncapd2	10711.0	-105.0
Ncapd3	11681.0	-13198.0
Ncapg	8006.0	5170.0
Ncapg2	13407.0	-8517.0
Ncaph	9662.0	-7763.0
Ncaph2	4224.0	91.0
Ndc1	13238.0	-12109.0
Ndc80	11305.0	-7543.0
Nde1	-6074.0	8864.0
Ndel1	-6462.0	-13712.0
Nedd1	-5802.0	-9203.0
Nek2	14119.0	-11365.0
Nek6	13921.0	-14431.0
Nek7	-8839.0	7258.0
Nek9	-8705.0	11327.0
Nhp2	-4543.0	-7331.0
Ninl	12966.0	-10855.0
Nipbl	-7169.0	-3159.0
Nme7	-10054.0	6679.0
Nop10	14932.0	-15027.0
Nsl1	2968.0	2930.0
Nudc	9181.0	-10432.0
Nuf2	8710.0	-9737.0
Numa1	-6029.0	10210.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Obfc1	10962.0	1945.0
Odf2	12329.0	-8688.0
Ofd1	12344.0	-10416.0
Oip5	10805.0	-8534.0
Optn	15124.0	-13664.0
Orc1	9734.0	-7991.0
Orc2	2889.0	-9894.0
Orc3	-4717.0	3382.0
Orc4	-5269.0	-2439.0
Orc5	10597.0	-8072.0
Orc6	374.0	-7010.0
Pafah1b1	4117.0	-10743.0
Pcbp4	-10989.0	12360.0
Pcm1	11605.0	-13363.0
Pcna	13367.0	-14114.0
Pcnt	11489.0	-8081.0
Pds5a	-2274.0	-8133.0
Pds5b	-8117.0	11104.0
Phf20	12053.0	-14031.0
Phf8	-1381.0	-4659.0
Phlda1	-8040.0	9959.0
Pias4	-9679.0	8206.0
Pif1	7985.0	-7316.0
Pkmyt1	10003.0	-8959.0
Plk1	9395.0	-5777.0
Plk4	2268.0	-7402.0
Pmf1	13680.0	-10495.0
Pola1	-8880.0	5777.0
Pola2	8004.0	-5681.0
Pold1	5255.0	4543.0
Pold2	12631.0	-8485.0
Pold3	-4233.0	6741.0
Pold4	7034.0	-12051.0
Pole	11606.0	-7660.0
Pole2	-7143.0	-143.0
Pole3	10431.0	-13031.0
Pole4	-11603.0	7992.0
Polr2a	5917.0	6827.0
Polr2b	-9995.0	7496.0
Polr2c	-2600.0	9289.0
Polr2d	-4100.0	39.0
Polr2e	11726.0	-9159.0
Polr2f	11374.0	-6543.0
Polr2g	11118.0	-13257.0
Polr2h	224.0	-7426.0
Polr2i	13554.0	-12640.0
Polr2j	9902.0	-6099.0
Polr2k	7520.0	-11503.0
Polr2l	6213.0	4463.0
Pom121	9659.0	-12785.0
Pot1a	-4539.0	2798.0
Ppme1	3702.0	3.0
Ppp1cb	4565.0	-10643.0
Ppp1cc	13589.0	-11988.0
Ppp1r12a	3470.0	-9878.0
Ppp1r12b	-7715.0	11767.0
Ppp2ca	2443.0	326.0
Ppp2cb	14291.0	-13381.0
Ppp2r1a	11507.0	3755.0
Ppp2r1b	-3062.0	-7202.0
Ppp2r2a	-1142.0	-9444.0
Ppp2r2d	12749.0	-14570.0
Ppp2r3d	-3033.0	6807.0
Ppp2r5a	14617.0	-14818.0
Ppp2r5b	-2576.0	4479.0
Ppp2r5c	12442.0	-9365.0
Ppp2r5d	11554.0	1834.0
Ppp2r5e	-4849.0	4842.0
Ppp6c	5727.0	-12586.0
Ppp6r3	-10825.0	11674.0
Prdm9	-4544.0	-5660.0
Prim1	-8624.0	10425.0
Prim2	-9097.0	5742.0
Prkar2b	-11024.0	2146.0
Prkca	-11577.0	11021.0
Prkcb	-7742.0	7077.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc3ip	-8272.0	1931.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptk6	-8916.0	7487.0
Pttg1	13199.0	-11759.0
Rab1a	-8474.0	2511.0
Rab1b	-6847.0	3621.0
Rab2a	-8200.0	-6726.0
Rab8a	-7413.0	-3395.0
Rad1	-6955.0	4321.0
Rad17	226.0	-6799.0
Rad21	-6091.0	-9748.0
Rad50	9654.0	-3235.0
Rad51	9950.0	-249.0
Rad51c	-11332.0	10034.0
Rad9a	8550.0	4566.0
Rad9b	6251.0	-7308.0
Rae1	-2818.0	7959.0
Ran	-340.0	-458.0
Ranbp2	-1884.0	-9227.0
Rangap1	-4113.0	2101.0
Rb1	15102.0	-13818.0
Rbbp4	-12462.0	12126.0
Rbbp7	225.0	-7926.0
Rbbp8	13717.0	-12966.0
Rbl1	-9375.0	11563.0
Rbl2	11787.0	-7420.0
Rbx1	2286.0	4532.0
Rcc1	-11744.0	12735.0
Rcc2	2405.0	7611.0
Rec8	13624.0	8232.0
Rfc1	9267.0	-10537.0
Rfc2	-6748.0	11476.0
Rfc3	13044.0	-6703.0
Rfc4	3874.0	2158.0
Rfc5	12334.0	8699.0
Rfwd2	-2988.0	-5509.0
Rhno1	7419.0	-5059.0
Rmi1	-9220.0	10169.0
Rmi2	9282.0	3955.0
Rnf168	-4091.0	-149.0
Rnf8	-2987.0	-6982.0
Rpa1	-5523.0	11078.0
Rpa2	6898.0	-2423.0
Rpa3	-2462.0	3353.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rrm2	14293.0	-13094.0
Rsf1	13831.0	-14144.0
Rtel1	5442.0	9777.0
Ruvbl1	-5892.0	8551.0
Ruvbl2	-9067.0	7462.0
Sdccag8	10406.0	-11798.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Set	-7029.0	5919.0
Sfi1	-8788.0	8246.0
Sfn	9301.0	71.0
Sgol1	-1679.0	7844.0
Sgol2a	8718.0	-3548.0
Shq1	-5132.0	-3585.0
Sirt2	9215.0	-457.0
Ska1	6709.0	-10296.0
Ska2	-9526.0	7541.0
Skp1a	-9392.0	1413.0
Skp2	-9937.0	5846.0
Smarca5	-10192.0	3369.0
Smc1a	3009.0	-11954.0
Smc1b	-377.5	2676.0
Smc2	194.0	-3587.0
Smc3	9972.0	-12948.0
Smc4	-3258.0	-8259.0
Spast	-7791.0	2757.0
Spc24	13403.0	-11390.0
Spc25	15273.0	-15132.0
Spdl1	10773.0	-10080.0
Spo11	-8743.0	11358.0
Src	8646.0	4243.0
Ssna1	-6691.0	-6655.0
Stag1	-9666.0	10304.0
Stag2	2947.0	-13895.0
Stag3	-10429.0	8496.0
Sumo1	-5337.0	-10745.0
Sun1	5347.0	8326.0
Sun2	14577.0	-13431.0
Syce1	8655.0	-2386.0
Syce2	12391.0	-6751.0
Sycp2	-8183.0	6602.0
Sycp3	-8114.0	7074.0
Syne2	-7818.0	-7089.0
Taok1	-4234.0	-10641.0
Ten1	-7854.0	-8245.0
Terf1	-3395.0	-5560.0
Terf2	-15.0	-5815.0
Terf2ip	-6777.0	9210.0
Tert	13272.0	17.0
Tex12	-2109.5	2317.5
Tex15	14085.0	-4780.0
Tfdp1	-7152.0	7854.0
Tfdp2	12095.0	-12073.0
Tinf2	6319.0	-3531.0
Tk1	-11584.0	10053.0
Tmpo	-11972.0	12265.0
Tnpo1	9194.0	-10888.0
Top2a	11131.0	-17.0
Top3a	-8478.0	-5110.0
Topbp1	4504.0	-5842.0
Tpr	-7568.0	-3358.0
Tpx2	12040.0	4167.0
Trp53	-7681.0	5460.0
Trp53bp1	-9861.0	10372.0
Tuba1a	-2804.0	-5493.0
Tuba1b	6722.0	5365.0
Tuba4a	-4434.0	8186.0
Tuba8	12324.0	-4975.0
Tubal3	876.5	-1222.5
Tubb1	-3307.0	-456.0
Tubb2a	11648.0	-11653.0
Tubb2b	14029.0	-12592.0
Tubb3	-1623.0	4178.0
Tubb4a	4305.0	7032.0
Tubb4b	-7669.0	7704.0
Tubb5	4901.0	-6793.0
Tubb6	-9629.0	9882.0
Tubg1	6654.0	8230.0
Tubg2	7002.0	2507.0
Tubgcp2	12709.0	9053.0
Tubgcp3	10323.0	-8943.0
Tubgcp4	-10450.0	8640.0
Tubgcp5	3415.0	-10011.0
Tubgcp6	-10196.0	8388.0
Tyms	7851.0	-10098.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2c	9861.0	-8024.0
Ube2d1	11721.0	-13291.0
Ube2e1	-10811.0	7252.0
Ube2i	13984.0	-13775.0
Ube2s	9693.0	-6037.0
Ube2v2	-8928.0	4163.0
Uimc1	-4365.0	352.0
Uso1	-8372.0	5238.0
Vps4a	-10273.0	7118.0
Vrk1	-3620.0	7646.0
Vrk2	-4483.0	1847.0
Wapl	-3476.0	-10206.0
Wee1	249.0	-14752.0
Wrap53	-6869.0	11009.0
Wrn	-3128.0	5665.0
Xpo1	-10778.0	9680.0
Ywhab	-3531.0	-52.0
Ywhae	2275.0	-8018.0
Ywhag	-10205.0	10203.0
Ywhah	3055.0	-11126.0
Ywhaq	12431.0	-12558.0
Zfp385a	15036.0	-8764.0
Zw10	-5911.0	7531.0
Zwilch	13125.0	-12780.0
Zwint	12999.0	-14462.0

---

---

Cell-surface-interactions-at-the-vascular-wall

Cell-surface-interactions-at-the-vascular-wall

metric	value
setSize	126
pMANOVA	0.0305
p.adjustMANOVA	0.117
s.dist	0.112
s.diab	-0.0184
s.PMX	0.111
p.diab	0.722
p.PMX	0.0314

Top 20 genes

Gene	diab	PMX
Itgax	-12597	12908
Proc	-12617	12555
Jchain	-12711	11904
Itgal	-11771	12813
Grb7	-12186	12119
Igha	-12348	11945
Jam3	-11372	12730
Selplg	-11481	12035
Cd44	-11921	11492
Igkc	-12203	11173
Itga4	-10182	12732
Sirpa	-10000	12631
Atp1b2	-10533	11952
Angpt1	-10474	11969
Sdc2	-11747	10378
Glg1	-10508	11595
Ighm	-9802	12152
Sos1	-11977	9665
Igkv1-135	-9391	12146
Pecam1	-9053	12320

Click HERE to show all gene set members

All member genes

	diab	PMX
Amica1	3041.0	6302.0
Angpt1	-10474.0	11969.0
Angpt2	10452.0	-12811.0
Angpt4	-6900.0	10132.0
Apob	14399.0	-9778.0
Atp1b1	15270.0	-15047.0
Atp1b2	-10533.0	11952.0
Atp1b3	9790.0	-13383.0
Bsg	10831.0	-9772.0
Cav1	-3675.0	10920.0
Cd177	3257.0	4081.0
Cd2	-8170.0	11027.0
Cd244	-11574.0	9198.0
Cd44	-11921.0	11492.0
Cd47	-5391.0	-2458.0
Cd48	-9932.0	9677.0
Cd74	-8967.0	7810.0
Cd84	-7621.0	4187.0
Cd99l2	-10908.0	394.0
Ceacam1	10562.0	8936.0
Dok2	13393.0	-14065.0
Epcam	14975.0	-14340.0
Esam	13721.0	-14152.0
F11r	11089.0	-13222.0
F2	-12078.0	3049.0
Fcamr	-12383.0	8129.0
Fcer1g	-7456.0	1655.0
Fn1	12346.0	6126.0
Fyn	-6985.0	9856.0
Gas6	13061.0	11070.0
Glg1	-10508.0	11595.0
Gm1123	9928.0	-12705.0
Gp6	-5160.0	6084.0
Gpc1	15341.0	-15137.0
Grb14	14357.0	-7399.0
Grb2	8972.0	3406.0
Grb7	-12186.0	12119.0
Gypa	-10015.0	10411.0
Gypc	-1420.0	1939.0
Hras	12615.0	-11955.0
Igha	-12348.0	11945.0
Ighm	-9802.0	12152.0
Ighv14-1	-4909.0	-6534.0
Ighv3-1	-3456.5	2317.5
Ighv5-4	-8748.0	6914.0
Ighv9-1	-5234.0	4881.0
Igkc	-12203.0	11173.0
Igkv1-135	-9391.0	12146.0
Igkv14-130	-3167.5	2317.5
Igkv17-127	-10984.0	6315.0
Igkv2-137	6752.0	-10319.0
Igll1	11837.0	-7314.0
Iglv3	-6624.0	4066.0
Inpp5d	42.0	6163.0
Itga3	9099.0	6566.0
Itga4	-10182.0	12732.0
Itga5	-6316.0	4295.0
Itga6	10749.0	-2876.0
Itgal	-11771.0	12813.0
Itgam	-8058.0	4871.0
Itgav	14776.0	-14797.0
Itgax	-12597.0	12908.0
Itgb1	5869.0	-13098.0
Itgb2l	4949.0	-3001.0
Itgb3	12310.0	-13769.0
Jam2	-8656.0	-7659.0
Jam3	-11372.0	12730.0
Jchain	-12711.0	11904.0
Kras	8243.0	-12396.0
L1cam	15340.0	-13068.0
Lck	-8490.0	10472.0
Lyn	-7639.0	6.0
Mag	6844.0	-8991.0
Mertk	-7988.0	-12712.0
Mif	15323.0	-14988.0
Nras	11707.0	-12390.0
Olr1	3032.0	2093.0
Pecam1	-9053.0	12320.0
Pf4	-6840.0	3083.0
Pick1	8170.0	-2819.0
Pik3ca	5274.0	-12270.0
Pik3cb	-11168.0	9586.0
Pik3r1	-5226.0	4551.0
Pik3r2	-4478.0	11254.0
Plcg1	15140.0	-14853.0
Ppia	14608.0	-14924.0
Ppil2	8843.0	-12309.0
Proc	-12617.0	12555.0
Procr	6693.0	2958.0
Pros1	13867.0	-7111.0
Psg16	13818.0	-14670.0
Ptpn11	-3808.0	6242.0
Ptpn6	-8957.0	10520.0
Sdc1	14043.0	1649.0
Sdc2	-11747.0	10378.0
Sdc3	-8537.0	11348.0
Sdc4	-5140.0	12375.0
Sele	11756.0	-10988.0
Sell	-11269.0	9620.0
Selp	13119.0	-12994.0
Selplg	-11481.0	12035.0
Shc1	-8826.0	9471.0
Sirpa	-10000.0	12631.0
Slc16a1	14346.0	-8035.0
Slc16a3	11553.0	-11018.0
Slc16a8	11805.0	-13519.0
Slc3a2	12234.0	-4863.0
Slc7a10	7075.0	-7559.0
Slc7a11	11318.0	-11511.0
Slc7a5	14136.0	-14270.0
Slc7a6	12977.0	-8707.0
Slc7a7	9157.0	5962.0
Slc7a8	13603.0	2754.0
Slc7a9	10955.0	-10703.0
Sos1	-11977.0	9665.0
Spn	-3874.0	11441.0
Src	8646.0	4243.0
Tek	3697.0	6880.0
Tgfb1	-11489.0	7819.0
Thbd	-2608.0	1465.0
Tnfrsf10b	14466.0	8404.0
Trem1	6582.0	255.0
Tspan7	14518.0	-13734.0
Vpreb1	10228.0	2737.0
Vpreb3	-3463.0	6270.0
Yes1	4717.0	-6854.0

---

---

TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain

TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain

metric	value
setSize	13
pMANOVA	0.864
p.adjustMANOVA	0.946
s.dist	0.112
s.diab	0.0768
s.PMX	-0.0817
p.diab	0.632
p.PMX	0.61

Top 20 genes

Gene	diab	PMX
Rabggtb	12899	-14355
Ndrg1	12041	-13368
Trp53bp2	12692	-12481
Birc5	12522	-11275

Click HERE to show all gene set members

All member genes

	diab	PMX
Bcl2l14	14259	2653
Bcl6	-11275	12055
Birc5	12522	-11275
Chm	-2990	-10097
Ndrg1	12041	-13368
Perp	-11532	5317
Ppp1r13b	12643	273
Rabggta	-12513	11451
Rabggtb	12899	-14355
Trp53	-7681	5460
Trp53bp2	12692	-12481
Trp63	-5205	-10040
Trp73	5178	5617

---

---

Programmed-Cell-Death

Programmed-Cell-Death

metric	value
setSize	185
pMANOVA	0.124
p.adjustMANOVA	0.247
s.dist	0.11
s.diab	0.0683
s.PMX	-0.0861
p.diab	0.109
p.PMX	0.0431

Top 20 genes

Gene	diab	PMX
Sdcbp	15153	-15107
Chmp4c	14654	-14956
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Dsg2	15025	-13950
Stat3	14430	-14454
Sptan1	14829	-14042
Rps27a	13894	-14715
E2f1	14773	-13127
Flot1	14308	-13529
Ocln	13628	-14190
Psma7	13781	-14022
Birc3	14412	-13340
Bcl2l1	13386	-13994
Psmc3	13783	-13466
Pmaip1	15067	-12274
Fas	13656	-13454
Chmp4b	13369	-13601
Ppp3cc	12629	-13978

Click HERE to show all gene set members

All member genes

	diab	PMX
Acin1	4961.0	-6070.0
Add1	-10711.0	8903.0
Akt1	11899.0	-4407.0
Akt2	-10282.0	10289.0
Akt3	-23.0	-6307.0
Apaf1	-3549.0	11897.0
Apc	13349.0	-8999.0
Apip	10598.0	-8306.0
Appl1	8488.0	-13267.0
Arhgap10	-12730.0	13015.0
Aven	-9158.0	11505.0
Bad	-4775.0	1095.0
Bak1	14669.0	-8609.0
Bax	11957.0	8555.0
Bcap31	-10749.0	-2252.0
Bcl2	-6750.0	11042.0
Bcl2l1	13386.0	-13994.0
Bcl2l11	10641.0	-10810.0
Bid	-5300.0	6403.0
Birc2	7611.0	-10452.0
Birc3	14412.0	-13340.0
Bmf	-9386.0	7691.0
Bmx	-2611.0	8210.0
C1qbp	-5400.0	10357.0
Casp1	-11186.0	11334.0
Casp3	13749.0	-9807.0
Casp4	-6856.0	-8055.0
Casp6	-1176.0	5396.0
Casp7	11312.0	4968.0
Casp8	-8679.0	-12376.0
Casp9	-10349.0	10594.0
Cd14	11247.0	-14430.0
Cdc37	-1879.0	-4421.0
Cdh1	-174.0	12292.0
Cflar	9464.0	-13798.0
Chmp2a	6531.0	-8482.0
Chmp2b	11049.0	-9912.0
Chmp3	8777.0	-13102.0
Chmp4b	13369.0	-13601.0
Chmp4c	14654.0	-14956.0
Chmp6	9126.0	9611.0
Chmp7	-7612.0	12648.0
Clspn	-4322.0	6551.0
Ctnnb1	-12039.0	12412.0
Cycs	8402.0	-13138.0
Dapk1	-3551.0	5160.0
Dapk2	-5181.0	12350.0
Dapk3	-221.0	-3347.0
Dbnl	9368.0	7787.0
Dffa	-1172.0	12098.0
Dffb	11853.0	-11341.0
Diablo	-5963.0	8829.0
Dnm1l	8840.0	-11982.0
Dsg1b	7980.0	4247.0
Dsg2	15025.0	-13950.0
Dsp	12069.0	-12608.0
Dynll1	-10023.0	-2241.0
Dynll2	-12351.0	10871.0
E2f1	14773.0	-13127.0
Fadd	-9345.0	10811.0
Fas	13656.0	-13454.0
Fasl	-3718.0	6336.0
Flot1	14308.0	-13529.0
Flot2	13212.0	-12960.0
Fnta	12029.0	-12661.0
Gas2	-12652.0	10306.0
Gsdmd	-5959.0	7991.0
Gsn	14953.0	-5680.0
Hmgb2	-1509.0	5671.0
Hsp90aa1	-12505.0	4614.0
Il18	9046.0	6574.0
Il1a	876.5	-1222.5
Il1b	-10853.0	6461.0
Irf1	-9511.0	10928.0
Irf2	-4303.0	-418.0
Kpna1	7639.0	-11114.0
Kpnb1	10908.0	1199.0
Lmna	5606.0	3857.0
Lmnb1	-9916.0	8126.0
Ly96	201.0	-8287.0
Maged1	-11852.0	11971.0
Mapk1	6867.0	-10406.0
Mapk3	10588.0	-6813.0
Mapk8	86.0	2880.0
Mapt	-11830.0	11877.0
Mlkl	11932.0	-10030.0
Nmt1	-8697.0	6173.0
Ocln	13628.0	-14190.0
Ogt	-3769.0	-9582.0
Oma1	-3059.0	5581.0
Opa1	343.0	-428.0
Pak2	-11115.0	10419.0
Pdcd6ip	-5824.0	3458.0
Peli1	8961.0	-12690.0
Pkp1	11012.0	-12124.0
Plec	11898.0	-8539.0
Pmaip1	15067.0	-12274.0
Ppp1r13b	12643.0	273.0
Ppp3cc	12629.0	-13978.0
Ppp3r1	8691.0	-9297.0
Prkcd	11350.0	-8872.0
Prkcq	-6737.0	3402.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptk2	9305.0	2859.0
Ripk1	-961.0	-5249.0
Ripk3	7523.0	-131.0
Rock1	4877.0	-11833.0
Rps27a	13894.0	-14715.0
Satb1	-8419.0	10588.0
Sdcbp	15153.0	-15107.0
Sfn	9301.0	71.0
Sptan1	14829.0	-14042.0
Stat3	14430.0	-14454.0
Stk24	12867.0	-7841.0
Stk26	13103.0	-8575.0
Stub1	122.0	4556.0
Tfdp1	-7152.0	7854.0
Tfdp2	12095.0	-12073.0
Ticam1	-7259.0	6702.0
Ticam2	4701.0	-9812.0
Tjp1	7975.0	4697.0
Tjp2	-7784.0	12172.0
Tlr4	-8099.0	6708.0
Tnfrsf10b	14466.0	8404.0
Tnfsf10	-12009.0	11185.0
Tradd	-7820.0	11319.0
Traf2	3101.0	-8023.0
Trp53	-7681.0	5460.0
Trp53bp2	12692.0	-12481.0
Trp63	-5205.0	-10040.0
Trp73	5178.0	5617.0
Uaca	-9406.0	12139.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Unc5a	-8229.0	9426.0
Unc5b	14534.0	9226.0
Vim	-6719.0	11410.0
Ywhab	-3531.0	-52.0
Ywhae	2275.0	-8018.0
Ywhag	-10205.0	10203.0
Ywhah	3055.0	-11126.0
Ywhaq	12431.0	-12558.0

---

---

Signaling-by-the-B-Cell-Receptor-(BCR)

Signaling-by-the-B-Cell-Receptor-(BCR)

metric	value
setSize	120
pMANOVA	0.00266
p.adjustMANOVA	0.0136
s.dist	0.102
s.diab	-0.0658
s.PMX	-0.0785
p.diab	0.213
p.PMX	0.137

Top 20 genes

Gene	diab	PMX
Psmd7	-9175	-8611
Chuk	-8103	-8635
Psmc6	-5320	-12074
Psma1	-6738	-7608
Rasgrp1	-3739	-13175
Nck1	-4016	-10473
Psmb4	-4466	-8497
Psme4	-4545	-7955
Psmd11	-4239	-7981
Trpc1	-6951	-4789
Psmd12	-5190	-6195
Ighv14-1	-4909	-6534
Psmd1	-4486	-6816
Ubb	-3411	-7959
Dapp1	-3460	-6642
Nfatc1	-2618	-8153
Ikbkb	-1527	-10168
Psmd6	-1663	-8390
Psmd5	-1595	-6026

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcyl1	6832.0	-14545.0
Bcl10	-5706.0	6387.0
Blk	3046.0	7612.0
Blnk	14946.0	-14514.0
Btk	-6343.0	9675.0
Btrc	-1383.0	8479.0
Calm1	152.0	-11443.0
Card11	-7798.0	11685.0
Cd19	-7122.0	7102.0
Cd22	-11312.0	11195.0
Cd79a	-11203.0	8822.0
Cd79b	-10852.0	12150.0
Chuk	-8103.0	-8635.0
Cul1	114.0	-11623.0
Dapp1	-3460.0	-6642.0
Fbxw11	-10435.0	9702.0
Fkbp1a	-4088.0	2763.0
Fyn	-6985.0	9856.0
Grb2	8972.0	3406.0
Hras	12615.0	-11955.0
Ighd	-11252.0	12232.0
Ighm	-9802.0	12152.0
Ighv14-1	-4909.0	-6534.0
Ighv3-1	-3456.5	2317.5
Ighv5-4	-8748.0	6914.0
Ighv9-1	-5234.0	4881.0
Igkc	-12203.0	11173.0
Igkv1-135	-9391.0	12146.0
Igkv14-130	-3167.5	2317.5
Igkv17-127	-10984.0	6315.0
Igkv2-137	6752.0	-10319.0
Igll1	11837.0	-7314.0
Ikbkb	-1527.0	-10168.0
Ikbkg	12618.0	-11493.0
Itpr1	10796.0	-11700.0
Itpr2	13551.0	7710.0
Itpr3	11003.0	2102.0
Kras	8243.0	-12396.0
Lyn	-7639.0	6.0
Malt1	-6834.0	10147.0
Map3k7	10607.0	-11166.0
Nck1	-4016.0	-10473.0
Nfatc1	-2618.0	-8153.0
Nfatc2	9333.0	9956.0
Nfatc3	-9186.0	3699.0
Nfkb1	234.0	10216.0
Nfkbia	14941.0	-14953.0
Nfkbib	12056.0	-11601.0
Nfkbie	-7903.0	8218.0
Nras	11707.0	-12390.0
Orai1	-6072.0	1991.0
Orai2	10183.0	-2454.0
Pik3ap1	-9717.0	10026.0
Pik3cd	-8249.0	9542.0
Pik3r1	-5226.0	4551.0
Plcg2	-2480.0	12667.0
Ppia	14608.0	-14924.0
Ppp3ca	12376.0	-9089.0
Ppp3cb	-6472.0	4604.0
Ppp3r1	8691.0	-9297.0
Prkcb	-7742.0	7077.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptpn6	-8957.0	10520.0
Rasgrp1	-3739.0	-13175.0
Rasgrp3	-12035.0	12755.0
Rel	10291.0	-11414.0
Rela	7998.0	-10978.0
Rps27a	13894.0	-14715.0
Sh3kbp1	6066.0	-2951.0
Skp1a	-9392.0	1413.0
Sos1	-11977.0	9665.0
Stim1	14942.0	-14174.0
Syk	-11535.0	11301.0
Trpc1	-6951.0	-4789.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Vav1	-9886.0	7973.0

---

---

Cell-cell-junction-organization

Cell-cell-junction-organization

metric	value
setSize	53
pMANOVA	0.274
p.adjustMANOVA	0.416
s.dist	0.0972
s.diab	0.097
s.PMX	-0.00576
p.diab	0.222
p.PMX	0.942

Top 20 genes

Gene	diab	PMX
Nectin1	15040	-14466
Cdh6	14279	-14377
Cldn19	14026	-14397
Cldn3	13399	-14457
Nectin2	14700	-12326
Cldn4	14680	-11852
Cldn15	14862	-11517
Cdh4	12570	-12281
F11r	11089	-13222
Cdh3	14386	-9982
Pvr	12149	-11086
Cldn7	13810	-9723
Cldn23	10399	-12378
Cldn11	11784	-9936
Cldn2	7747	-14483
Cldn14	13725	-8003
Sdk2	14079	-7766
Sdk1	14935	-6001
Prkci	7391	-10491
Cdh17	4740	-8372

Click HERE to show all gene set members

All member genes

	diab	PMX
Cadm1	-12680.0	12287.0
Cadm2	-7082.0	12271.0
Cadm3	4497.0	5204.0
Cdh1	-174.0	12292.0
Cdh10	-3437.0	7052.5
Cdh11	-9468.0	12564.0
Cdh13	-11949.0	12201.0
Cdh17	4740.0	-8372.0
Cdh2	-12474.0	5089.0
Cdh24	-3952.0	8158.0
Cdh3	14386.0	-9982.0
Cdh4	12570.0	-12281.0
Cdh5	-9073.0	12582.0
Cdh6	14279.0	-14377.0
Cdh8	1803.5	-2073.5
Cldn1	12954.0	2518.0
Cldn10	-12555.0	9350.0
Cldn11	11784.0	-9936.0
Cldn12	-10344.0	-6381.0
Cldn14	13725.0	-8003.0
Cldn15	14862.0	-11517.0
Cldn16	-7272.0	7202.0
Cldn17	-5763.0	1333.0
Cldn18	-11451.0	9869.0
Cldn19	14026.0	-14397.0
Cldn2	7747.0	-14483.0
Cldn20	-119.0	-6513.0
Cldn23	10399.0	-12378.0
Cldn3	13399.0	-14457.0
Cldn4	14680.0	-11852.0
Cldn5	-4673.0	11618.0
Cldn6	-8284.0	5503.0
Cldn7	13810.0	-9723.0
Cldn8	13832.0	3064.0
Cldn9	-6452.0	-4993.0
Crb3	11061.0	5579.0
Ctnna1	5895.0	2751.0
Ctnnb1	-12039.0	12412.0
F11r	11089.0	-13222.0
Jup	-4725.0	9124.0
Mpp5	-10314.0	-13200.0
Nectin1	15040.0	-14466.0
Nectin2	14700.0	-12326.0
Nectin3	-11266.0	9186.0
Nectin4	10771.0	7852.0
Pard3	-7793.0	-5508.0
Pard6a	2407.0	-8357.0
Pard6b	-34.0	10283.0
Pard6g	11905.0	6083.0
Prkci	7391.0	-10491.0
Pvr	12149.0	-11086.0
Sdk1	14935.0	-6001.0
Sdk2	14079.0	-7766.0

---

---

Cell-Cell-communication

Cell-Cell-communication

metric	value
setSize	110
pMANOVA	0.202
p.adjustMANOVA	0.361
s.dist	0.0863
s.diab	0.084
s.PMX	-0.0197
p.diab	0.128
p.PMX	0.721

Top 20 genes

Gene	diab	PMX
Nectin1	15040	-14466
Sptbn1	14290	-14606
Sptan1	14829	-14042
Cdh6	14279	-14377
Cldn19	14026	-14397
Cask	13958	-14155
Cldn3	13399	-14457
Lamc2	15047	-12749
Parva	14174	-13205
Itgb4	14708	-12358
Nectin2	14700	-12326
Lamb3	12930	-13656
Cldn4	14680	-11852
Cldn15	14862	-11517
Cd151	12960	-12761
Cd2ap	13647	-11788
Col17a1	13341	-11901
Dst	12167	-12864
Cdh4	12570	-12281
Iqgap1	14527	-10145

Click HERE to show all gene set members

All member genes

	diab	PMX
Actn1	-2955.0	-9395.0
Actn2	13375.0	-10971.0
Actn3	11524.0	2632.0
Actn4	5239.0	9097.0
Arhgef6	10050.0	5932.0
Cadm1	-12680.0	12287.0
Cadm2	-7082.0	12271.0
Cadm3	4497.0	5204.0
Cask	13958.0	-14155.0
Cd151	12960.0	-12761.0
Cd2ap	13647.0	-11788.0
Cd47	-5391.0	-2458.0
Cdh1	-174.0	12292.0
Cdh10	-3437.0	7052.5
Cdh11	-9468.0	12564.0
Cdh13	-11949.0	12201.0
Cdh17	4740.0	-8372.0
Cdh2	-12474.0	5089.0
Cdh24	-3952.0	8158.0
Cdh3	14386.0	-9982.0
Cdh4	12570.0	-12281.0
Cdh5	-9073.0	12582.0
Cdh6	14279.0	-14377.0
Cdh8	1803.5	-2073.5
Cldn1	12954.0	2518.0
Cldn10	-12555.0	9350.0
Cldn11	11784.0	-9936.0
Cldn12	-10344.0	-6381.0
Cldn14	13725.0	-8003.0
Cldn15	14862.0	-11517.0
Cldn16	-7272.0	7202.0
Cldn17	-5763.0	1333.0
Cldn18	-11451.0	9869.0
Cldn19	14026.0	-14397.0
Cldn2	7747.0	-14483.0
Cldn20	-119.0	-6513.0
Cldn23	10399.0	-12378.0
Cldn3	13399.0	-14457.0
Cldn4	14680.0	-11852.0
Cldn5	-4673.0	11618.0
Cldn6	-8284.0	5503.0
Cldn7	13810.0	-9723.0
Cldn8	13832.0	3064.0
Cldn9	-6452.0	-4993.0
Col17a1	13341.0	-11901.0
Crb3	11061.0	5579.0
Ctnna1	5895.0	2751.0
Ctnnb1	-12039.0	12412.0
Dst	12167.0	-12864.0
F11r	11089.0	-13222.0
Fblim1	-2605.0	-9339.0
Fermt2	-6317.0	-9249.0
Flna	-8364.0	9099.0
Flnc	5925.0	-12857.0
Fyb	-11760.0	9306.0
Fyn	-6985.0	9856.0
Grb2	8972.0	3406.0
Ilk	-313.0	-495.0
Iqgap1	14527.0	-10145.0
Itga6	10749.0	-2876.0
Itgb1	5869.0	-13098.0
Itgb4	14708.0	-12358.0
Jup	-4725.0	9124.0
Kirrel	-5626.0	10328.0
Kirrel2	8017.0	6175.0
Kirrel3	-9431.0	2836.0
Lama3	-9254.0	7235.0
Lamb3	12930.0	-13656.0
Lamc2	15047.0	-12749.0
Lims1	-8618.0	3597.0
Lims2	-11479.0	10148.0
Magi2	-8986.0	11098.0
Mpp5	-10314.0	-13200.0
Nck1	-4016.0	-10473.0
Nck2	-5920.0	1627.0
Nectin1	15040.0	-14466.0
Nectin2	14700.0	-12326.0
Nectin3	-11266.0	9186.0
Nectin4	10771.0	7852.0
Nphs1	9978.0	11962.0
Pard3	-7793.0	-5508.0
Pard6a	2407.0	-8357.0
Pard6b	-34.0	10283.0
Pard6g	11905.0	6083.0
Parva	14174.0	-13205.0
Parvb	-6686.0	-4411.0
Pik3ca	5274.0	-12270.0
Pik3cb	-11168.0	9586.0
Pik3r1	-5226.0	4551.0
Pik3r2	-4478.0	11254.0
Plec	11898.0	-8539.0
Prkci	7391.0	-10491.0
Ptk2	9305.0	2859.0
Ptk2b	-11310.0	12917.0
Ptpn11	-3808.0	6242.0
Ptpn6	-8957.0	10520.0
Pvr	12149.0	-11086.0
Pxn	5824.0	-177.0
Rsu1	-7576.0	-2947.0
Sdk1	14935.0	-6001.0
Sdk2	14079.0	-7766.0
Sirpa	-10000.0	12631.0
Skap2	5625.0	-6565.0
Sptan1	14829.0	-14042.0
Sptbn1	14290.0	-14606.0
Src	8646.0	4243.0
Tesk1	7984.0	9088.0
Tyrobp	-4198.0	-8348.0
Vasp	-3832.0	4449.0
Wasl	6310.0	-10820.0

---

---

Cell-recruitment-(pro-inflammatory-response)

Cell-recruitment-(pro-inflammatory-response)

metric	value
setSize	24
pMANOVA	0.9
p.adjustMANOVA	0.954
s.dist	0.0693
s.diab	-0.0445
s.PMX	0.053
p.diab	0.706
p.PMX	0.653

Top 20 genes

Gene	diab	PMX
Hsp90ab1	-12580	11764
Casp1	-11186	11334
Pstpip1	-10529	11013
Hmox1	-10213	8284
Mefv	-7814	9211
Il1b	-10853	6461
Nlrp3	-8573	7411
Gsdmd	-5959	7991

Click HERE to show all gene set members

All member genes

	diab	PMX
C3	15250.0	-14907.0
C3ar1	-4139.0	-6179.0
Casp1	-11186.0	11334.0
Entpd1	15235.0	-14142.0
Entpd5	-3477.0	-2420.0
Gsdmd	-5959.0	7991.0
Hmox1	-10213.0	8284.0
Hsp90ab1	-12580.0	11764.0
Il18	9046.0	6574.0
Il1a	876.5	-1222.5
Il1b	-10853.0	6461.0
Mefv	-7814.0	9211.0
Nfkb1	234.0	10216.0
Nfkb2	8531.0	1475.0
Nlrp3	-8573.0	7411.0
Nt5e	-9052.0	-9847.0
P2rx4	13993.0	-11444.0
P2rx7	10761.0	-3230.0
Pstpip1	-10529.0	11013.0
Pycard	10546.0	8949.0
Rela	7998.0	-10978.0
Sugt1	9604.0	-6859.0
Txn1	-6434.0	-12085.0
Txnip	15044.0	-15001.0

---

---

TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain

TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain

metric	value
setSize	19
pMANOVA	0.933
p.adjustMANOVA	0.954
s.dist	0.0621
s.diab	0.0488
s.PMX	-0.0384
p.diab	0.713
p.PMX	0.772

Top 20 genes

Gene	diab	PMX
Btg2	15122	-14014
Rgcc	14711	-13598
Plk3	14013	-14168
Plagl1	14219	-8257
Cnot6l	6231	-12283
Cdc25c	9859	-6321
Tnks1bp1	4119	-14130

Click HERE to show all gene set members

All member genes

	diab	PMX
Btg2	15122	-14014
Cdc25c	9859	-6321
Cenpj	-11728	6522
Cnot1	2862	4781
Cnot10	8561	1690
Cnot11	-131	2908
Cnot2	-6965	6675
Cnot3	-8690	6241
Cnot4	-7023	1964
Cnot6	-4378	2900
Cnot6l	6231	-12283
Cnot7	-8230	-5989
Cnot8	-10527	7261
Plagl1	14219	-8257
Plk2	13531	11848
Plk3	14013	-14168
Rgcc	14711	-13598
Tnks1bp1	4119	-14130
Trp53	-7681	5460

---

---

Oxidative-Stress-Induced-Senescence

Oxidative-Stress-Induced-Senescence

metric	value
setSize	62
pMANOVA	0.786
p.adjustMANOVA	0.92
s.dist	0.054
s.diab	-0.0489
s.PMX	0.0229
p.diab	0.506
p.PMX	0.755

Top 20 genes

Gene	diab	PMX
Rbbp4	-12462	12126
Cbx4	-12196	11468
Mapk11	-11176	11985
Cbx8	-11721	11385
Phc1	-10307	10457
Ago3	-10688	9354
E2f2	-10922	8773
Map2k3	-11214	8360
Tnrc6b	-8828	9395
Cbx6	-6489	12600
Tnrc6c	-6877	11145
Eed	-9201	7028
Cbx2	-6995	8685
Bmi1	-6546	9252
Tfdp1	-7152	7854
Suz12	-6254	8020
Mov10	-9876	4432
Trp53	-7681	5460
Mink1	-4422	8509
H2afx	-3852	6424

Click HERE to show all gene set members

All member genes

	diab	PMX
Ago1	13694	-4416
Ago3	-10688	9354
Ago4	4723	6013
Bmi1	-6546	9252
Cbx2	-6995	8685
Cbx4	-12196	11468
Cbx6	-6489	12600
Cbx8	-11721	11385
Cdk4	7497	6438
Cdk6	-8022	-8784
Cdkn2b	14383	-14293
Cdkn2c	-1158	9132
Cdkn2d	5293	2129
E2f1	14773	-13127
E2f2	-10922	8773
E2f3	9873	3869
Eed	-9201	7028
Ezh2	13058	-14025
Fos	5077	22
H2afx	-3852	6424
Jun	9574	-13518
Kdm6b	-3039	-7197
Map2k3	-11214	8360
Map2k4	9926	-8899
Map2k6	8630	-9645
Map2k7	12018	-8043
Map3k5	10364	-13897
Map4k4	-6607	13
Mapk1	6867	-10406
Mapk10	6586	-10216
Mapk11	-11176	11985
Mapk14	-12047	34
Mapk3	10588	-6813
Mapk8	86	2880
Mapk9	12784	-5874
Mapkapk2	14192	-11215
Mapkapk3	8522	6234
Mapkapk5	41	3388
Mdm2	15095	-7329
Mdm4	-4386	-13416
Mink1	-4422	8509
Mov10	-9876	4432
Phc1	-10307	10457
Phc2	9767	-7629
Phc3	-8753	-8471
Rbbp4	-12462	12126
Rbbp7	225	-7926
Ring1	-7720	3003
Rnf2	5830	-10843
Rps27a	13894	-14715
Scmh1	7958	5549
Suz12	-6254	8020
Tfdp1	-7152	7854
Tfdp2	12095	-12073
Tnik	-1447	2760
Tnrc6a	8288	-10563
Tnrc6b	-8828	9395
Tnrc6c	-6877	11145
Trp53	-7681	5460
Txn1	-6434	-12085
Uba52	4596	-6796
Ubb	-3411	-7959

---

---

DNA-Damage/Telomere-Stress-Induced-Senescence

DNA-Damage/Telomere-Stress-Induced-Senescence

metric	value
setSize	28
pMANOVA	0.774
p.adjustMANOVA	0.92
s.dist	0.0506
s.diab	0.00999
s.PMX	0.0496
p.diab	0.927
p.PMX	0.649

Top 20 genes

Gene	diab	PMX
Atm	11462	2585
Kat5	4420	6683
Hmga2	4574	275
Cdkn1b	4380	258

Click HERE to show all gene set members

All member genes

	diab	PMX
Acd	-4896	9107
Asf1a	-6271	-233
Atm	11462	2585
Cabin1	-3241	8514
Ccna2	12043	-6678
Ccne1	8507	-10924
Ccne2	4837	-11061
Cdk2	12902	-12285
Cdkn1a	15394	-12557
Cdkn1b	4380	258
Ep400	-6397	9291
H2afx	-3852	6424
Hira	-2684	4510
Hmga1	14417	-11978
Hmga2	4574	275
Kat5	4420	6683
Lmnb1	-9916	8126
Mre11a	-5960	7726
Nbn	-7224	-4610
Pot1a	-4539	2798
Rad50	9654	-3235
Rb1	15102	-13818
Terf1	-3395	-5560
Terf2	-15	-5815
Terf2ip	-6777	9210
Tinf2	6319	-3531
Trp53	-7681	5460
Ubn1	-10645	11079

---

---

Oncogene-Induced-Senescence

Oncogene-Induced-Senescence

metric	value
setSize	31
pMANOVA	0.736
p.adjustMANOVA	0.92
s.dist	0.0504
s.diab	-0.0148
s.PMX	-0.0481
p.diab	0.886
p.PMX	0.643

Top 20 genes

Gene	diab	PMX
Cdk6	-8022	-8784
Mdm4	-4386	-13416
Id1	-5552	-9376
Erf	-4112	-11941
Ubb	-3411	-7959

Click HERE to show all gene set members

All member genes

	diab	PMX
Ago1	13694	-4416
Ago3	-10688	9354
Ago4	4723	6013
Cdk4	7497	6438
Cdk6	-8022	-8784
Cdkn2b	14383	-14293
Cdkn2c	-1158	9132
Cdkn2d	5293	2129
E2f1	14773	-13127
E2f2	-10922	8773
E2f3	9873	3869
Erf	-4112	-11941
Ets1	-12235	12571
Ets2	-11047	10868
Id1	-5552	-9376
Mapk1	6867	-10406
Mapk3	10588	-6813
Mdm2	15095	-7329
Mdm4	-4386	-13416
Mov10	-9876	4432
Rb1	15102	-13818
Rps27a	13894	-14715
Sp1	-10774	4387
Tfdp1	-7152	7854
Tfdp2	12095	-12073
Tnrc6a	8288	-10563
Tnrc6b	-8828	9395
Tnrc6c	-6877	11145
Trp53	-7681	5460
Uba52	4596	-6796
Ubb	-3411	-7959

---

---

Cell-death-signalling-via-NRAGE,-NRIF-and-NADE

Cell-death-signalling-via-NRAGE,-NRIF-and-NADE

metric	value
setSize	73
pMANOVA	0.541
p.adjustMANOVA	0.732
s.dist	0.0496
s.diab	0.049
s.PMX	0.00785
p.diab	0.469
p.PMX	0.908

Top 20 genes

Gene	diab	PMX
Arhgef17	9033	10831
Arhgef18	12070	6649
Arhgef6	10050	5932
Arhgef2	5161	9462
Abr	5382	8593
Mcf2l	10616	1746
Mcf2	6383	2501
Mapk8	86	2880

Click HERE to show all gene set members

All member genes

	diab	PMX
Aatf	9765	-12186
Abr	5382	8593
Akap13	9135	-13489
Aph1a	-620	4686
Aph1b	13941	-13577
Arhgef1	-4280	7936
Arhgef10	-7339	9915
Arhgef10l	-12170	12996
Arhgef11	9956	-369
Arhgef12	-12030	10200
Arhgef15	-12052	12723
Arhgef16	-1056	9094
Arhgef17	9033	10831
Arhgef18	12070	6649
Arhgef19	-10659	11682
Arhgef2	5161	9462
Arhgef26	12067	-13084
Arhgef3	14506	-14694
Arhgef33	14828	-14427
Arhgef37	14978	-14679
Arhgef38	13842	-9440
Arhgef39	-12435	12532
Arhgef4	15266	-12127
Arhgef40	-9136	6457
Arhgef5	12939	-13338
Arhgef6	10050	5932
Arhgef7	12872	-10663
Arhgef9	14955	-14756
Bad	-4775	1095
Bcl2l11	10641	-10810
Casp2	8278	-11205
Casp3	13749	-9807
Ect2	-1535	-11756
Fgd1	-3945	4745
Fgd2	-10217	12011
Fgd3	-8287	-12454
Fgd4	-1468	11977
Gna13	5728	-8712
Itgb3bp	4897	-8304
Itsn1	-6360	7586
Kalrn	13678	-5190
Maged1	-11852	11971
Mapk8	86	2880
Mcf2	6383	2501
Mcf2l	10616	1746
Ncstn	14410	-12169
Net1	14636	-15123
Ngef	-11571	-8755
Ngf	-6631	2748
Ngfr	10298	-6900
Obscn	-6032	7137
Plekhg2	-10885	11872
Plekhg5	-1787	80
Prex1	-8529	12218
Psen1	-11531	9651
Psen2	7176	-5828
Psenen	-7498	6057
Rac1	-4047	262
Rasgrf2	9870	-9198
Rps27a	13894	-14715
Sos1	-11977	9665
Sos2	-5483	3046
Sqstm1	-7943	9582
Tiam1	13330	-11554
Tiam2	-6226	500
Traf6	13741	-14203
Trio	-9497	12173
Uba52	4596	-6796
Ubb	-3411	-7959
Vav1	-9886	7973
Vav2	-4852	12450
Vav3	14614	-14980
Ywhae	2275	-8018

---

---

EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination

EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination

metric	value
setSize	27
pMANOVA	0.934
p.adjustMANOVA	0.954
s.dist	0.0446
s.diab	-0.0398
s.PMX	0.0202
p.diab	0.72
p.PMX	0.856

Top 20 genes

Gene	diab	PMX
Nab2	-12557	12629
Lama2	-12274	12567
Lamb1	-8857	11401
Hdac2	-9129	7139
Egr2	-8943	6151
Yap1	-7550	6222
Smarca4	-4424	10551
Nab1	-9570	4452
Srebf2	-4237	9342
Pmp22	-3954	6790
Tead1	-3955	2810
Sox10	-1524	3549

Click HERE to show all gene set members

All member genes

	diab	PMX
Adgrg6	12923	-14467
Adgrv1	10549	-5789
Cyp51	11509	-15089
Dag1	14086	305
Drp2	2856	-2916
Egr2	-8943	6151
Gjb1	-1862	-13995
Hdac2	-9129	7139
Hmgcr	-11695	-12651
Lama2	-12274	12567
Lamb1	-8857	11401
Lamc1	13297	-9372
Mag	6844	-8991
Mbp	14194	3469
Mpz	11473	-447
Nab1	-9570	4452
Nab2	-12557	12629
Pmp22	-3954	6790
Pou3f1	-1704	-5253
Prx	5888	-3055
Smarca4	-4424	10551
Sox10	-1524	3549
Srebf2	-4237	9342
Tead1	-3955	2810
Utrn	13490	-12047
Wwtr1	5283	-14386
Yap1	-7550	6222

---

---

Diseases-of-programmed-cell-death

Diseases-of-programmed-cell-death

metric	value
setSize	42
pMANOVA	0.8
p.adjustMANOVA	0.92
s.dist	0.0436
s.diab	-0.0436
s.PMX	2e-04
p.diab	0.625
p.PMX	0.998

Top 20 genes

Gene	diab	PMX
Dnmt3a	-12219	12965
Rbbp4	-12462	12126
Dnmt1	-9863	10248
Fadd	-9345	10811
Prim1	-8624	10425
Tradd	-7820	11319
App	-8366	10137
Prdx1	-11307	7421
Lmnb1	-9916	8126
Eed	-9201	7028
C1qbp	-5400	10357
Prim2	-9097	5742
Pola1	-8880	5777
Suz12	-6254	8020
Trp53	-7681	5460
Capns2	-3872	8278
H2afx	-3852	6424
Fasl	-3718	6336

Click HERE to show all gene set members

All member genes

	diab	PMX
App	-8366	10137
Bcl2l11	10641	-10810
C1qbp	-5400	10357
Capn1	15297	-14590
Capn2	14380	-14044
Capns1	10893	-14245
Capns2	-3872	8278
Casp8	-8679	-12376
Cast	13527	-11562
Cdc25a	3462	-12613
Cdc25b	8473	6982
Cdc25c	9859	-6321
Cdk5	9839	2913
Cdk5r1	-4054	-4627
Dnmt1	-9863	10248
Dnmt3a	-12219	12965
Dnmt3b	3290	280
Eed	-9201	7028
Ezh2	13058	-14025
Fadd	-9345	10811
Fasl	-3718	6336
Foxo3	14625	-14429
Golga2	14538	-13457
H2afx	-3852	6424
Jun	9574	-13518
Lmna	5606	3857
Lmnb1	-9916	8126
Pola1	-8880	5777
Pola2	8004	-5681
Prdx1	-11307	7421
Prdx2	14368	-13945
Prim1	-8624	10425
Prim2	-9097	5742
Rbbp4	-12462	12126
Rbbp7	225	-7926
Ripk1	-961	-5249
Sod2	5661	-10164
Suz12	-6254	8020
Tradd	-7820	11319
Traf2	3101	-8023
Trp53	-7681	5460
Ywhae	2275	-8018

---

---

TP53-Regulates-Transcription-of-Cell-Death-Genes

TP53-Regulates-Transcription-of-Cell-Death-Genes

metric	value
setSize	37
pMANOVA	0.84
p.adjustMANOVA	0.943
s.dist	0.0373
s.diab	0.0055
s.PMX	0.0369
p.diab	0.954
p.PMX	0.698

Top 20 genes

Gene	diab	PMX
Tnfrsf10b	14466	8404
Bax	11957	8555
Bcl2l14	14259	2653
Atm	11462	2585
Trp73	5178	5617
Ppp1r13b	12643	273

Click HERE to show all gene set members

All member genes

	diab	PMX
Aifm2	11725	-3780
Apaf1	-3549	11897
Atm	11462	2585
Bax	11957	8555
Bcl2l14	14259	2653
Bcl6	-11275	12055
Bid	-5300	6403
Birc5	12522	-11275
Bnip3l	-4880	-13318
Casp1	-11186	11334
Casp2	8278	-11205
Casp6	-1176	5396
Chm	-2990	-10097
Cradd	-9168	8664
Crebbp	7115	-7498
Fas	13656	-13454
Igfbp3	-12060	12876
Ndrg1	12041	-13368
Nlrc4	-12130	5387
Perp	-11532	5317
Pidd1	-1135	-8779
Pmaip1	15067	-12274
Ppp1r13b	12643	273
Prelid1	-4414	1639
Rabggta	-12513	11451
Rabggtb	12899	-14355
Slmo1	5847	-3763
Steap3	-11527	9153
Tmem219	-4797	-6817
Tnfrsf10b	14466	8404
Triap1	-7647	2924
Trp53	-7681	5460
Trp53bp2	12692	-12481
Trp53inp1	15269	-14119
Trp63	-5205	-10040
Trp73	5178	5617
Zfp420	-5708	8399

---

---

Cellular-Senescence

Cellular-Senescence

metric	value
setSize	124
pMANOVA	0.954
p.adjustMANOVA	0.954
s.dist	0.00952
s.diab	-0.00377
s.PMX	-0.00874
p.diab	0.942
p.PMX	0.866

Top 20 genes

Gene	diab	PMX
Txn1	-6434	-12085
Phc3	-8753	-8471
Cdk6	-8022	-8784
Igfbp7	-6756	-9670
Mdm4	-4386	-13416
Id1	-5552	-9376
Erf	-4112	-11941
Ehmt1	-4418	-10516
Cdc27	-6730	-6274
Nbn	-7224	-4610
Ubb	-3411	-7959
Anapc15	-2513	-9553
Kdm6b	-3039	-7197
Terf1	-3395	-5560
Anapc11	-4767	-2276
Asf1a	-6271	-233
Anapc10	-40	-7692
Terf2	-15	-5815

Click HERE to show all gene set members

All member genes

	diab	PMX
Acd	-4896.0	9107.0
Ago1	13694.0	-4416.0
Ago3	-10688.0	9354.0
Ago4	4723.0	6013.0
Anapc1	-11278.0	10450.0
Anapc10	-40.0	-7692.0
Anapc11	-4767.0	-2276.0
Anapc15	-2513.0	-9553.0
Anapc16	13128.0	-13447.0
Anapc2	-3217.0	9388.0
Anapc4	14276.0	-12248.0
Anapc5	14536.0	-12088.0
Anapc7	10824.0	-6183.0
Asf1a	-6271.0	-233.0
Atm	11462.0	2585.0
Bmi1	-6546.0	9252.0
Cabin1	-3241.0	8514.0
Cbx2	-6995.0	8685.0
Cbx4	-12196.0	11468.0
Cbx6	-6489.0	12600.0
Cbx8	-11721.0	11385.0
Ccna2	12043.0	-6678.0
Ccne1	8507.0	-10924.0
Ccne2	4837.0	-11061.0
Cdc16	10625.0	-286.0
Cdc23	180.0	8382.0
Cdc26	8205.0	-5823.0
Cdc27	-6730.0	-6274.0
Cdk2	12902.0	-12285.0
Cdk4	7497.0	6438.0
Cdk6	-8022.0	-8784.0
Cdkn1a	15394.0	-12557.0
Cdkn1b	4380.0	258.0
Cdkn2b	14383.0	-14293.0
Cdkn2c	-1158.0	9132.0
Cdkn2d	5293.0	2129.0
Cebpb	15167.0	-15133.0
E2f1	14773.0	-13127.0
E2f2	-10922.0	8773.0
E2f3	9873.0	3869.0
Eed	-9201.0	7028.0
Ehmt1	-4418.0	-10516.0
Ehmt2	4354.0	10437.0
Ep400	-6397.0	9291.0
Erf	-4112.0	-11941.0
Ets1	-12235.0	12571.0
Ets2	-11047.0	10868.0
Ezh2	13058.0	-14025.0
Fos	5077.0	22.0
Fzr1	-2715.0	9851.0
H2afx	-3852.0	6424.0
Hira	-2684.0	4510.0
Hmga1	14417.0	-11978.0
Hmga2	4574.0	275.0
Id1	-5552.0	-9376.0
Igfbp7	-6756.0	-9670.0
Il1a	876.5	-1222.5
Il6	-2929.0	3096.0
Jun	9574.0	-13518.0
Kat5	4420.0	6683.0
Kdm6b	-3039.0	-7197.0
Lmnb1	-9916.0	8126.0
Map2k3	-11214.0	8360.0
Map2k4	9926.0	-8899.0
Map2k6	8630.0	-9645.0
Map2k7	12018.0	-8043.0
Map3k5	10364.0	-13897.0
Map4k4	-6607.0	13.0
Mapk1	6867.0	-10406.0
Mapk10	6586.0	-10216.0
Mapk11	-11176.0	11985.0
Mapk14	-12047.0	34.0
Mapk3	10588.0	-6813.0
Mapk7	-1452.0	6080.0
Mapk8	86.0	2880.0
Mapk9	12784.0	-5874.0
Mapkapk2	14192.0	-11215.0
Mapkapk3	8522.0	6234.0
Mapkapk5	41.0	3388.0
Mdm2	15095.0	-7329.0
Mdm4	-4386.0	-13416.0
Mink1	-4422.0	8509.0
Mov10	-9876.0	4432.0
Mre11a	-5960.0	7726.0
Nbn	-7224.0	-4610.0
Nfkb1	234.0	10216.0
Phc1	-10307.0	10457.0
Phc2	9767.0	-7629.0
Phc3	-8753.0	-8471.0
Pot1a	-4539.0	2798.0
Rad50	9654.0	-3235.0
Rb1	15102.0	-13818.0
Rbbp4	-12462.0	12126.0
Rbbp7	225.0	-7926.0
Rela	7998.0	-10978.0
Ring1	-7720.0	3003.0
Rnf2	5830.0	-10843.0
Rps27a	13894.0	-14715.0
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Scmh1	7958.0	5549.0
Sp1	-10774.0	4387.0
Stat3	14430.0	-14454.0
Suz12	-6254.0	8020.0
Terf1	-3395.0	-5560.0
Terf2	-15.0	-5815.0
Terf2ip	-6777.0	9210.0
Tfdp1	-7152.0	7854.0
Tfdp2	12095.0	-12073.0
Tinf2	6319.0	-3531.0
Tnik	-1447.0	2760.0
Tnrc6a	8288.0	-10563.0
Tnrc6b	-8828.0	9395.0
Tnrc6c	-6877.0	11145.0
Trp53	-7681.0	5460.0
Txn1	-6434.0	-12085.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2c	9861.0	-8024.0
Ube2d1	11721.0	-13291.0
Ube2e1	-10811.0	7252.0
Ube2s	9693.0	-6037.0
Ubn1	-10645.0	11079.0

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.2               GGally_2.1.2               
##  [3] ggplot2_3.4.0               reshape2_1.4.4             
##  [5] beeswarm_0.4.0              gplots_3.1.3               
##  [7] gtools_3.9.4                tibble_3.1.8               
##  [9] echarts4r_0.4.4             kableExtra_1.3.4           
## [11] dplyr_1.0.10                mitch_1.11.1               
## [13] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [15] Biobase_2.56.0              MatrixGenerics_1.8.1       
## [17] matrixStats_0.63.0          GenomicRanges_1.48.0       
## [19] GenomeInfoDb_1.32.4         IRanges_2.30.1             
## [21] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_2.0-3       ellipsis_0.3.2         XVector_0.36.0        
##  [4] rstudioapi_0.14        farver_2.1.1           bit64_4.0.5           
##  [7] AnnotationDbi_1.58.0   fansi_1.0.3            xml2_1.3.3            
## [10] codetools_0.2-18       splines_4.2.1          cachem_1.0.6          
## [13] geneplotter_1.74.0     knitr_1.41             jsonlite_1.8.3        
## [16] annotate_1.74.0        png_0.1-8              shiny_1.7.3           
## [19] compiler_4.2.1         httr_1.4.4             assertthat_0.2.1      
## [22] Matrix_1.5-3           fastmap_1.1.0          cli_3.4.1             
## [25] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
## [28] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
## [31] Rcpp_1.0.9             jquerylib_0.1.4        vctrs_0.5.1           
## [34] Biostrings_2.64.1      svglite_2.1.0          xfun_0.35             
## [37] stringr_1.4.1          rvest_1.0.3            mime_0.12             
## [40] lifecycle_1.0.3        XML_3.99-0.12          zlibbioc_1.42.0       
## [43] MASS_7.3-58.1          scales_1.2.1           promises_1.2.0.1      
## [46] parallel_4.2.1         RColorBrewer_1.1-3     yaml_2.3.6            
## [49] memoise_2.0.1          gridExtra_2.3          sass_0.4.4            
## [52] reshape_0.8.9          stringi_1.7.8          RSQLite_2.2.19        
## [55] highr_0.9              genefilter_1.78.0      caTools_1.18.2        
## [58] BiocParallel_1.30.4    rlang_1.0.6            pkgconfig_2.0.3       
## [61] systemfonts_1.0.4      bitops_1.0-7           evaluate_0.18         
## [64] lattice_0.20-45        htmlwidgets_1.5.4      labeling_0.4.2        
## [67] bit_4.0.5              tidyselect_1.2.0       plyr_1.8.8            
## [70] magrittr_2.0.3         R6_2.5.1               generics_0.1.3        
## [73] DelayedArray_0.22.0    DBI_1.1.3              pillar_1.8.1          
## [76] withr_2.5.0            survival_3.4-0         KEGGREST_1.36.3       
## [79] RCurl_1.98-1.9         crayon_1.5.2           KernSmooth_2.23-20    
## [82] utf8_1.2.2             rmarkdown_2.18         locfit_1.5-9.6        
## [85] grid_4.2.1             blob_1.2.3             digest_0.6.30         
## [88] webshot_0.5.4          xtable_1.8-4           httpuv_1.6.6          
## [91] munsell_0.5.0          viridisLite_0.4.1      bslib_0.4.1

END of report