Mitch Report

date generated: 2022-12-03

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	diab	PMX
0610006L08Rik	-5.5412223	1.7043723
0610007P14Rik	-0.5043192	0.5154128
0610009B22Rik	-1.1468556	0.7601283
0610009E02Rik	-1.0617246	0.7364015
0610009L18Rik	-3.4134523	2.9613348
0610009O20Rik	-1.1413048	1.7889029

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	28178
duplicated_genes_present	0
num_profile_genes_in_sets	9011
num_profile_genes_not_in_sets	19167
profile_pearson_correl	-0.74519
profile_spearman_correl	-0.68447

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_mouse.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2504
num_genesets_excluded	1022
num_genesets_included	1482

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 312

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

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## haozhu233.github.io/kableExtra/ for details.

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diab	s.PMX	p.diab	p.PMX
Viral-mRNA-Translation	73	2.05e-33	1.52e-30	1.070	0.701	-0.802	3.15e-25	1.64e-32
Peptide-chain-elongation	73	1.36e-32	6.71e-30	1.050	0.699	-0.789	4.63e-25	1.69e-31
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	85	1.11e-34	1.65e-31	1.010	0.665	-0.757	2.47e-26	1.35e-33
Eukaryotic-Translation-Elongation	77	2.80e-31	6.91e-29	1.000	0.665	-0.753	5.05e-24	2.61e-30
Formation-of-a-pool-of-free-40S-subunits	85	2.20e-32	8.16e-30	0.976	0.653	-0.725	2.00e-25	5.44e-31
Eukaryotic-Translation-Termination	77	4.39e-29	5.92e-27	0.970	0.646	-0.723	9.58e-23	4.67e-28
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex	46	2.88e-17	1.71e-15	0.963	0.660	-0.701	9.20e-15	1.88e-16
Selenocysteine-synthesis	76	9.92e-27	1.13e-24	0.935	0.624	-0.696	4.92e-21	7.72e-26
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	79	3.34e-27	4.12e-25	0.925	0.617	-0.690	2.42e-21	2.63e-26
Phosphorylation-of-CD3-and-TCR-zeta-chains	17	1.36e-06	4.02e-05	0.896	-0.523	0.727	1.86e-04	2.08e-07
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit	96	2.23e-31	6.62e-29	0.895	0.578	-0.684	1.14e-22	3.98e-31
PD-1-signaling	17	2.65e-06	7.41e-05	0.895	-0.555	0.702	7.37e-05	5.30e-07
Translocation-of-ZAP-70-to-Immunological-synapse	14	2.05e-05	3.38e-04	0.892	-0.535	0.714	5.27e-04	3.69e-06
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression	95	4.56e-30	9.66e-28	0.883	0.574	-0.671	3.79e-22	1.08e-29
Ribosomal-scanning-and-start-codon-recognition	53	1.26e-15	6.90e-14	0.841	0.545	-0.641	6.61e-12	6.60e-16
Cap-dependent-Translation-Initiation	103	4.08e-29	5.92e-27	0.837	0.551	-0.630	4.15e-22	1.83e-28
Eukaryotic-Translation-Initiation	103	4.08e-29	5.92e-27	0.837	0.551	-0.630	4.15e-22	1.83e-28
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S	54	3.11e-15	1.53e-13	0.825	0.541	-0.623	6.13e-12	2.24e-15
Gluconeogenesis	30	1.22e-08	4.53e-07	0.824	0.600	-0.565	1.25e-08	8.28e-08
Translation-initiation-complex-formation	53	1.24e-14	5.72e-13	0.815	0.532	-0.617	1.96e-11	7.69e-15
Acetylcholine-regulates-insulin-secretion	10	3.40e-03	2.03e-02	0.791	-0.520	0.596	4.40e-03	1.09e-03
SRP-dependent-cotranslational-protein-targeting-to-membrane	96	6.92e-26	7.33e-24	0.786	0.465	-0.633	3.24e-15	6.67e-27
Response-of-EIF2AK1-(HRI)-to-heme-deficiency	15	2.72e-04	2.65e-03	0.759	0.466	-0.599	1.76e-03	5.85e-05
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	99	5.66e-23	4.66e-21	0.758	0.507	-0.564	2.59e-18	2.75e-22
Nonsense-Mediated-Decay-(NMD)	99	5.66e-23	4.66e-21	0.758	0.507	-0.564	2.59e-18	2.75e-22
Organic-cation/anion/zwitterion-transport	12	1.99e-03	1.29e-02	0.757	-0.502	0.567	2.61e-03	6.75e-04
Complex-I-biogenesis	54	7.15e-13	3.12e-11	0.757	0.500	-0.568	1.98e-10	5.21e-13
Selenoamino-acid-metabolism	91	3.37e-21	2.63e-19	0.756	0.496	-0.570	2.52e-16	5.20e-21
Synthesis-of-PE	12	2.52e-03	1.60e-02	0.748	0.528	-0.530	1.52e-03	1.48e-03
Citric-acid-cycle-(TCA-cycle)	22	2.15e-05	3.47e-04	0.738	0.501	-0.542	4.71e-05	1.06e-05
Cellular-response-to-starvation	138	2.09e-29	3.87e-27	0.734	0.517	-0.521	8.43e-26	3.42e-26
Defective-GALNT12-causes-colorectal-cancer-1-(CRCS1)	12	1.35e-03	9.66e-03	0.729	0.606	-0.405	2.78e-04	1.50e-02
STING-mediated-induction-of-host-immune-responses	12	3.31e-03	2.00e-02	0.718	-0.459	0.552	5.94e-03	9.18e-04
CD22-mediated-BCR-regulation	17	3.16e-04	2.98e-03	0.712	-0.555	0.447	7.52e-05	1.40e-03
Influenza-Viral-RNA-Transcription-and-Replication	118	8.50e-24	8.40e-22	0.711	0.489	-0.516	4.21e-20	3.11e-22
Mitochondrial-tRNA-aminoacylation	18	3.13e-04	2.97e-03	0.705	-0.526	0.468	1.10e-04	5.79e-04
Alpha-protein-kinase-1-signaling-pathway	10	8.73e-03	4.27e-02	0.703	0.427	-0.559	1.93e-02	2.20e-03
Glutamate-and-glutamine-metabolism	12	4.90e-03	2.72e-02	0.700	0.463	-0.525	5.49e-03	1.65e-03
Interleukin-2-signaling	11	8.99e-03	4.37e-02	0.687	-0.518	0.451	2.94e-03	9.61e-03
Respiratory-electron-transport	99	3.24e-19	2.19e-17	0.681	0.430	-0.527	1.31e-13	1.07e-19
IRF3-mediated-induction-of-type-I-IFN	10	9.15e-03	4.42e-02	0.675	-0.377	0.559	3.89e-02	2.19e-03
Regulation-of-KIT-signaling	16	1.06e-03	7.88e-03	0.671	-0.412	0.530	4.28e-03	2.42e-04
tRNA-processing-in-the-mitochondrion	16	2.12e-03	1.36e-02	0.657	0.474	-0.455	1.04e-03	1.62e-03
Basigin-interactions	24	1.55e-05	2.74e-04	0.655	0.553	-0.351	2.67e-06	2.93e-03
HS-GAG-degradation	20	1.79e-04	1.82e-03	0.651	-0.370	0.536	4.19e-03	3.27e-05
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	107	1.42e-18	9.15e-17	0.643	0.406	-0.499	3.53e-13	4.52e-19
Bicarbonate-transporters	10	1.09e-06	3.36e-05	0.631	0.622	0.104	6.55e-04	5.69e-01
Influenza-Infection	134	1.07e-20	7.91e-19	0.620	0.423	-0.454	2.72e-17	1.05e-19
Regulation-of-expression-of-SLITs-and-ROBOs	149	4.28e-23	3.97e-21	0.608	0.379	-0.475	1.18e-15	1.16e-23
Metabolism-of-Angiotensinogen-to-Angiotensins	12	2.00e-02	8.22e-02	0.604	0.415	-0.439	1.28e-02	8.44e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diab	s.PMX	p.diab	p.PMX
Viral-mRNA-Translation	73	2.05e-33	1.52e-30	1.07000	7.01e-01	-0.802000	3.15e-25	1.64e-32
Peptide-chain-elongation	73	1.36e-32	6.71e-30	1.05000	6.99e-01	-0.789000	4.63e-25	1.69e-31
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	85	1.11e-34	1.65e-31	1.01000	6.65e-01	-0.757000	2.47e-26	1.35e-33
Eukaryotic-Translation-Elongation	77	2.80e-31	6.91e-29	1.00000	6.65e-01	-0.753000	5.05e-24	2.61e-30
Formation-of-a-pool-of-free-40S-subunits	85	2.20e-32	8.16e-30	0.97600	6.53e-01	-0.725000	2.00e-25	5.44e-31
Eukaryotic-Translation-Termination	77	4.39e-29	5.92e-27	0.97000	6.46e-01	-0.723000	9.58e-23	4.67e-28
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex	46	2.88e-17	1.71e-15	0.96300	6.60e-01	-0.701000	9.20e-15	1.88e-16
Selenocysteine-synthesis	76	9.92e-27	1.13e-24	0.93500	6.24e-01	-0.696000	4.92e-21	7.72e-26
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	79	3.34e-27	4.12e-25	0.92500	6.17e-01	-0.690000	2.42e-21	2.63e-26
Phosphorylation-of-CD3-and-TCR-zeta-chains	17	1.36e-06	4.02e-05	0.89600	-5.23e-01	0.727000	1.86e-04	2.08e-07
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit	96	2.23e-31	6.62e-29	0.89500	5.78e-01	-0.684000	1.14e-22	3.98e-31
PD-1-signaling	17	2.65e-06	7.41e-05	0.89500	-5.55e-01	0.702000	7.37e-05	5.30e-07
Translocation-of-ZAP-70-to-Immunological-synapse	14	2.05e-05	3.38e-04	0.89200	-5.35e-01	0.714000	5.27e-04	3.69e-06
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression	95	4.56e-30	9.66e-28	0.88300	5.74e-01	-0.671000	3.79e-22	1.08e-29
Ribosomal-scanning-and-start-codon-recognition	53	1.26e-15	6.90e-14	0.84100	5.45e-01	-0.641000	6.61e-12	6.60e-16
Cap-dependent-Translation-Initiation	103	4.08e-29	5.92e-27	0.83700	5.51e-01	-0.630000	4.15e-22	1.83e-28
Eukaryotic-Translation-Initiation	103	4.08e-29	5.92e-27	0.83700	5.51e-01	-0.630000	4.15e-22	1.83e-28
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S	54	3.11e-15	1.53e-13	0.82500	5.41e-01	-0.623000	6.13e-12	2.24e-15
Gluconeogenesis	30	1.22e-08	4.53e-07	0.82400	6.00e-01	-0.565000	1.25e-08	8.28e-08
Translation-initiation-complex-formation	53	1.24e-14	5.72e-13	0.81500	5.32e-01	-0.617000	1.96e-11	7.69e-15
Acetylcholine-regulates-insulin-secretion	10	3.40e-03	2.03e-02	0.79100	-5.20e-01	0.596000	4.40e-03	1.09e-03
SRP-dependent-cotranslational-protein-targeting-to-membrane	96	6.92e-26	7.33e-24	0.78600	4.65e-01	-0.633000	3.24e-15	6.67e-27
Response-of-EIF2AK1-(HRI)-to-heme-deficiency	15	2.72e-04	2.65e-03	0.75900	4.66e-01	-0.599000	1.76e-03	5.85e-05
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	99	5.66e-23	4.66e-21	0.75800	5.07e-01	-0.564000	2.59e-18	2.75e-22
Nonsense-Mediated-Decay-(NMD)	99	5.66e-23	4.66e-21	0.75800	5.07e-01	-0.564000	2.59e-18	2.75e-22
Organic-cation/anion/zwitterion-transport	12	1.99e-03	1.29e-02	0.75700	-5.02e-01	0.567000	2.61e-03	6.75e-04
Complex-I-biogenesis	54	7.15e-13	3.12e-11	0.75700	5.00e-01	-0.568000	1.98e-10	5.21e-13
Selenoamino-acid-metabolism	91	3.37e-21	2.63e-19	0.75600	4.96e-01	-0.570000	2.52e-16	5.20e-21
Synthesis-of-PE	12	2.52e-03	1.60e-02	0.74800	5.28e-01	-0.530000	1.52e-03	1.48e-03
Citric-acid-cycle-(TCA-cycle)	22	2.15e-05	3.47e-04	0.73800	5.01e-01	-0.542000	4.71e-05	1.06e-05
Cellular-response-to-starvation	138	2.09e-29	3.87e-27	0.73400	5.17e-01	-0.521000	8.43e-26	3.42e-26
Defective-GALNT12-causes-colorectal-cancer-1-(CRCS1)	12	1.35e-03	9.66e-03	0.72900	6.06e-01	-0.405000	2.78e-04	1.50e-02
STING-mediated-induction-of-host-immune-responses	12	3.31e-03	2.00e-02	0.71800	-4.59e-01	0.552000	5.94e-03	9.18e-04
CD22-mediated-BCR-regulation	17	3.16e-04	2.98e-03	0.71200	-5.55e-01	0.447000	7.52e-05	1.40e-03
Influenza-Viral-RNA-Transcription-and-Replication	118	8.50e-24	8.40e-22	0.71100	4.89e-01	-0.516000	4.21e-20	3.11e-22
Mitochondrial-tRNA-aminoacylation	18	3.13e-04	2.97e-03	0.70500	-5.26e-01	0.468000	1.10e-04	5.79e-04
Alpha-protein-kinase-1-signaling-pathway	10	8.73e-03	4.27e-02	0.70300	4.27e-01	-0.559000	1.93e-02	2.20e-03
Glutamate-and-glutamine-metabolism	12	4.90e-03	2.72e-02	0.70000	4.63e-01	-0.525000	5.49e-03	1.65e-03
Interleukin-2-signaling	11	8.99e-03	4.37e-02	0.68700	-5.18e-01	0.451000	2.94e-03	9.61e-03
Respiratory-electron-transport	99	3.24e-19	2.19e-17	0.68100	4.30e-01	-0.527000	1.31e-13	1.07e-19
IRF3-mediated-induction-of-type-I-IFN	10	9.15e-03	4.42e-02	0.67500	-3.77e-01	0.559000	3.89e-02	2.19e-03
Regulation-of-KIT-signaling	16	1.06e-03	7.88e-03	0.67100	-4.12e-01	0.530000	4.28e-03	2.42e-04
tRNA-processing-in-the-mitochondrion	16	2.12e-03	1.36e-02	0.65700	4.74e-01	-0.455000	1.04e-03	1.62e-03
Basigin-interactions	24	1.55e-05	2.74e-04	0.65500	5.53e-01	-0.351000	2.67e-06	2.93e-03
HS-GAG-degradation	20	1.79e-04	1.82e-03	0.65100	-3.70e-01	0.536000	4.19e-03	3.27e-05
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	107	1.42e-18	9.15e-17	0.64300	4.06e-01	-0.499000	3.53e-13	4.52e-19
Bicarbonate-transporters	10	1.09e-06	3.36e-05	0.63100	6.22e-01	0.104000	6.55e-04	5.69e-01
Influenza-Infection	134	1.07e-20	7.91e-19	0.62000	4.23e-01	-0.454000	2.72e-17	1.05e-19
Regulation-of-expression-of-SLITs-and-ROBOs	149	4.28e-23	3.97e-21	0.60800	3.79e-01	-0.475000	1.18e-15	1.16e-23
Metabolism-of-Angiotensinogen-to-Angiotensins	12	2.00e-02	8.22e-02	0.60400	4.15e-01	-0.439000	1.28e-02	8.44e-03
A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis	24	6.79e-06	1.55e-04	0.59800	-2.44e-01	0.547000	3.87e-02	3.54e-06
Generation-of-second-messenger-molecules	29	9.31e-05	1.07e-03	0.59800	-4.05e-01	0.440000	1.61e-04	4.15e-05
Passive-transport-by-Aquaporins	11	2.29e-02	9.03e-02	0.58300	4.78e-01	-0.334000	6.01e-03	5.52e-02
TICAM1,TRAF6-dependent-induction-of-TAK1-complex	10	4.43e-02	1.44e-01	0.58300	3.76e-01	-0.445000	3.97e-02	1.47e-02
Amino-acid-transport-across-the-plasma-membrane	33	2.84e-05	4.29e-04	0.58000	4.55e-01	-0.360000	5.94e-06	3.45e-04
Interaction-between-L1-and-Ankyrins	26	7.45e-05	8.83e-04	0.57700	4.92e-01	-0.302000	1.42e-05	7.58e-03
tRNA-Aminoacylation	23	1.44e-03	1.01e-02	0.56500	-4.10e-01	0.388000	6.68e-04	1.26e-03
Glutathione-synthesis-and-recycling	12	2.30e-02	9.03e-02	0.56200	-4.58e-01	0.327000	6.05e-03	4.99e-02
FCGR-activation	24	8.93e-04	6.82e-03	0.56200	-4.34e-01	0.357000	2.32e-04	2.43e-03
Defective-GALNT3-causes-familial-hyperphosphatemic-tumoral-calcinosis-(HFTC)	12	2.02e-02	8.29e-02	0.55900	4.65e-01	-0.309000	5.24e-03	6.35e-02
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport	155	3.99e-20	2.82e-18	0.55400	3.44e-01	-0.434000	1.30e-13	8.78e-21
TICAM1,-RIP1-mediated-IKK-complex-recruitment	17	2.54e-04	2.52e-03	0.54800	1.80e-01	-0.518000	1.98e-01	2.19e-04
ATF6-(ATF6-alpha)-activates-chaperones	12	1.39e-02	6.27e-02	0.54600	-4.79e-01	0.262000	4.05e-03	1.16e-01
BBSome-mediated-cargo-targeting-to-cilium	21	3.65e-03	2.15e-02	0.54100	-4.11e-01	0.352000	1.11e-03	5.27e-03
Cristae-formation	13	1.72e-02	7.34e-02	0.53400	4.55e-01	-0.281000	4.54e-03	7.96e-02
Defective-pyroptosis	13	3.52e-02	1.25e-01	0.53400	-3.98e-01	0.356000	1.30e-02	2.61e-02
PRC2-methylates-histones-and-DNA	14	1.42e-02	6.39e-02	0.52900	-4.49e-01	0.279000	3.65e-03	7.02e-02
Defective-C1GALT1C1-causes-Tn-polyagglutination-syndrome-(TNPS)	13	4.01e-02	1.34e-01	0.52700	3.67e-01	-0.378000	2.20e-02	1.81e-02
Defective-B3GALT6-causes-EDSP2-and-SEMDJL1	18	7.95e-04	6.27e-03	0.52500	-2.03e-01	0.484000	1.35e-01	3.81e-04
Defective-B3GAT3-causes-JDSSDHD	18	6.49e-04	5.31e-03	0.52400	-1.95e-01	0.486000	1.51e-01	3.54e-04
Keratan-sulfate-degradation	10	8.60e-02	2.15e-01	0.52200	-3.50e-01	0.388000	5.54e-02	3.38e-02
Interleukin-35-Signalling	12	4.29e-02	1.40e-01	0.52100	-4.16e-01	0.314000	1.25e-02	5.98e-02
Elevation-of-cytosolic-Ca2+-levels	15	1.71e-03	1.15e-02	0.51900	4.87e-01	-0.177000	1.08e-03	2.34e-01
Acetylcholine-Neurotransmitter-Release-Cycle	14	2.15e-02	8.70e-02	0.51500	4.28e-01	-0.288000	5.60e-03	6.24e-02
Dermatan-sulfate-biosynthesis	10	3.78e-02	1.30e-01	0.51300	-2.35e-01	0.455000	1.97e-01	1.26e-02
Sodium/Calcium-exchangers	10	3.58e-02	1.26e-01	0.51000	4.57e-01	-0.227000	1.24e-02	2.14e-01
Insulin-receptor-recycling	25	1.02e-04	1.15e-03	0.50800	4.67e-01	-0.200000	5.22e-05	8.30e-02
Interleukin-27-signaling	11	3.97e-02	1.34e-01	0.50400	-4.37e-01	0.250000	1.20e-02	1.51e-01
MASTL-Facilitates-Mitotic-Progression	10	9.71e-02	2.34e-01	0.50200	3.87e-01	-0.320000	3.41e-02	7.96e-02
Fertilization	19	1.03e-02	4.92e-02	0.50000	3.99e-01	-0.302000	2.62e-03	2.26e-02
N-glycan-trimming-in-the-ER-and-Calnexin/Calreticulin-cycle	33	1.54e-04	1.60e-03	0.49900	-4.20e-01	0.268000	2.89e-05	7.69e-03
NOTCH2-intracellular-domain-regulates-transcription	11	8.14e-02	2.07e-01	0.49800	-3.21e-01	0.381000	6.50e-02	2.86e-02
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol	162	6.41e-17	3.65e-15	0.49200	3.00e-01	-0.390000	4.39e-11	9.57e-18
Defective-B4GALT7-causes-EDS,-progeroid-type	18	1.40e-03	1.00e-02	0.48800	-1.74e-01	0.456000	2.00e-01	8.11e-04
Assembly-Of-The-HIV-Virion	14	3.56e-02	1.26e-01	0.48600	2.78e-01	-0.399000	7.22e-02	9.81e-03
IKK-complex-recruitment-mediated-by-RIP1	21	1.56e-04	1.61e-03	0.48600	1.38e-01	-0.466000	2.74e-01	2.20e-04
Calnexin/calreticulin-cycle	24	1.91e-03	1.25e-02	0.48500	-4.15e-01	0.251000	4.36e-04	3.35e-02
Aspartate-and-asparagine-metabolism	11	6.37e-02	1.79e-01	0.48300	2.59e-01	-0.408000	1.37e-01	1.92e-02
ATF6-(ATF6-alpha)-activates-chaperone-genes	10	3.66e-02	1.27e-01	0.48200	-4.43e-01	0.190000	1.52e-02	2.98e-01
NOTCH3-Intracellular-Domain-Regulates-Transcription	25	3.41e-03	2.03e-02	0.48100	-2.84e-01	0.389000	1.39e-02	7.67e-04
Signaling-by-ROBO-receptors	192	3.39e-18	2.10e-16	0.47800	3.06e-01	-0.367000	2.26e-13	1.58e-18
Regulation-of-signaling-by-CBL	18	2.06e-02	8.40e-02	0.47800	-2.95e-01	0.376000	3.01e-02	5.77e-03
Condensation-of-Prometaphase-Chromosomes	11	9.68e-02	2.34e-01	0.47400	3.73e-01	-0.293000	3.23e-02	9.26e-02
alpha-linolenic-(omega3)-and-linoleic-(omega6)-acid-metabolism	12	2.91e-03	1.79e-02	0.47200	7.89e-02	-0.465000	6.36e-01	5.25e-03
alpha-linolenic-acid-(ALA)-metabolism	12	2.91e-03	1.79e-02	0.47200	7.89e-02	-0.465000	6.36e-01	5.25e-03
Membrane-binding-and-targetting-of-GAG-proteins	12	6.65e-02	1.85e-01	0.46700	2.59e-01	-0.388000	1.20e-01	1.99e-02
Synthesis-And-Processing-Of-GAG,-GAGPOL-Polyproteins	12	6.65e-02	1.85e-01	0.46700	2.59e-01	-0.388000	1.20e-01	1.99e-02
ABC-transporters-in-lipid-homeostasis	17	1.85e-02	7.74e-02	0.45400	2.29e-01	-0.392000	1.02e-01	5.13e-03
RMTs-methylate-histone-arginines	29	3.44e-03	2.04e-02	0.45400	-2.78e-01	0.358000	9.50e-03	8.32e-04
Chondroitin-sulfate/dermatan-sulfate-metabolism	48	3.46e-05	4.88e-04	0.45300	-2.50e-01	0.378000	2.71e-03	5.89e-06
TRAF6-mediated-NF-kB-activation	21	2.22e-02	8.83e-02	0.44900	3.02e-01	-0.333000	1.66e-02	8.30e-03
Other-semaphorin-interactions	19	1.00e-03	7.51e-03	0.44800	-1.22e-01	0.431000	3.57e-01	1.13e-03
Transferrin-endocytosis-and-recycling	29	1.98e-04	2.00e-03	0.44500	4.13e-01	-0.166000	1.18e-04	1.21e-01
Formation-of-the-beta-catenin:TCF-transactivating-complex	32	5.96e-04	4.96e-03	0.44400	-2.17e-01	0.388000	3.36e-02	1.46e-04
rRNA-processing-in-the-nucleus-and-cytosol	172	6.74e-15	3.22e-13	0.44400	2.66e-01	-0.355000	1.75e-09	8.42e-16
WNT-ligand-biogenesis-and-trafficking	23	1.16e-02	5.41e-02	0.44100	2.56e-01	-0.359000	3.38e-02	2.84e-03
Glutamate-Neurotransmitter-Release-Cycle	24	1.05e-02	4.97e-02	0.43900	3.55e-01	-0.258000	2.57e-03	2.88e-02
Activation-of-the-TFAP2-(AP-2)-family-of-transcription-factors	10	5.10e-02	1.55e-01	0.43800	4.10e-01	-0.154000	2.47e-02	4.00e-01
Signal-regulatory-protein-family-interactions	11	1.12e-01	2.55e-01	0.43700	-2.40e-01	0.364000	1.67e-01	3.63e-02
Budding-and-maturation-of-HIV-virion	25	1.47e-02	6.58e-02	0.43500	3.15e-01	-0.300000	6.39e-03	9.48e-03
rRNA-processing	191	1.49e-15	7.91e-14	0.43400	2.65e-01	-0.344000	2.63e-10	2.28e-16
Na+/Cl–dependent-neurotransmitter-transporters	18	4.01e-02	1.34e-01	0.43300	2.64e-01	-0.343000	5.26e-02	1.18e-02
Signaling-by-FGFR4-in-disease	11	2.85e-02	1.06e-01	0.43000	1.25e-01	-0.412000	4.72e-01	1.80e-02
Plasma-lipoprotein-remodeling	30	3.18e-04	2.98e-03	0.43000	1.65e-01	-0.397000	1.18e-01	1.67e-04
GPVI-mediated-activation-cascade	31	5.70e-03	3.08e-02	0.43000	-2.85e-01	0.321000	6.04e-03	1.94e-03
Regulation-of-IFNA-signaling	12	8.88e-02	2.18e-01	0.42700	-2.22e-01	0.365000	1.83e-01	2.86e-02
Interleukin-6-signaling	11	1.67e-01	3.35e-01	0.42700	-2.91e-01	0.312000	9.49e-02	7.30e-02
Synaptic-adhesion-like-molecules	21	1.05e-03	7.80e-03	0.42600	4.10e-01	-0.117000	1.15e-03	3.52e-01
Interleukin-3,-Interleukin-5-and-GM-CSF-signaling	40	1.54e-03	1.05e-02	0.42600	-2.93e-01	0.310000	1.36e-03	7.02e-04
Defective-EXT1-causes-exostoses-1,-TRPS2-and-CHDS	13	7.71e-03	3.85e-02	0.42600	-8.49e-02	0.417000	5.96e-01	9.22e-03
Defective-EXT2-causes-exostoses-2	13	7.71e-03	3.85e-02	0.42600	-8.49e-02	0.417000	5.96e-01	9.22e-03
Signaling-by-Leptin	10	8.67e-02	2.15e-01	0.42400	1.76e-01	-0.385000	3.35e-01	3.48e-02
Crosslinking-of-collagen-fibrils	10	2.40e-04	2.41e-03	0.42300	3.44e-01	0.247000	5.98e-02	1.76e-01
ERCC6-(CSB)-and-EHMT2-(G9a)-positively-regulate-rRNA-expression	16	5.06e-02	1.55e-01	0.42300	-2.34e-01	0.353000	1.05e-01	1.46e-02
Regulation-of-TLR-by-endogenous-ligand	16	6.47e-02	1.81e-01	0.42300	2.57e-01	-0.336000	7.48e-02	2.01e-02
Regulation-of-innate-immune-responses-to-cytosolic-DNA	12	1.11e-01	2.55e-01	0.42100	-3.49e-01	0.236000	3.61e-02	1.57e-01
Translesion-synthesis-by-REV1	15	5.68e-02	1.68e-01	0.42100	3.56e-01	-0.225000	1.69e-02	1.32e-01
Translesion-synthesis-by-POLK	16	2.37e-02	9.27e-02	0.42100	3.80e-01	-0.181000	8.48e-03	2.09e-01
NOTCH4-Intracellular-Domain-Regulates-Transcription	20	2.79e-02	1.05e-01	0.42000	-2.40e-01	0.345000	6.34e-02	7.48e-03
RUNX3-regulates-NOTCH-signaling	14	1.04e-01	2.44e-01	0.42000	-3.21e-01	0.270000	3.74e-02	7.98e-02
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell	94	1.69e-07	5.69e-06	0.41900	-2.58e-01	0.330000	1.50e-05	3.11e-08
Norepinephrine-Neurotransmitter-Release-Cycle	18	1.98e-02	8.16e-02	0.41800	3.72e-01	-0.192000	6.33e-03	1.58e-01
eNOS-activation	11	7.46e-02	1.98e-01	0.41500	-3.78e-01	0.171000	2.99e-02	3.25e-01
Signaling-by-PDGF	53	5.19e-05	6.52e-04	0.41300	-2.18e-01	0.351000	6.10e-03	9.66e-06
Pyrimidine-salvage	10	2.10e-01	3.83e-01	0.41300	3.14e-01	-0.268000	8.55e-02	1.42e-01
RUNX1-interacts-with-co-factors-whose-precise-effect-on-RUNX1-targets-is-not-known	36	2.77e-03	1.73e-02	0.41100	-3.29e-01	0.246000	6.28e-04	1.06e-02
Interleukin-2-family-signaling	40	1.94e-03	1.26e-02	0.41100	-2.61e-01	0.317000	4.26e-03	5.16e-04
Deregulated-CDK5-triggers-multiple-neurodegenerative-pathways-in-Alzheimer’s-disease-models	22	3.81e-02	1.30e-01	0.40700	3.00e-01	-0.274000	1.47e-02	2.60e-02
Neurodegenerative-Diseases	22	3.81e-02	1.30e-01	0.40700	3.00e-01	-0.274000	1.47e-02	2.60e-02
Plasma-lipoprotein-assembly	17	4.75e-03	2.67e-02	0.40600	9.87e-02	-0.394000	4.81e-01	4.94e-03
Regulation-of-gene-expression-in-late-stage-(branching-morphogenesis)-pancreatic-bud-precursor-cells	14	1.29e-01	2.82e-01	0.40500	-2.92e-01	0.281000	5.84e-02	6.87e-02
RHOBTB2-GTPase-cycle	20	1.09e-02	5.16e-02	0.40500	-3.69e-01	0.166000	4.22e-03	1.98e-01
Lysine-catabolism	12	1.46e-01	3.06e-01	0.40500	-3.26e-01	0.240000	5.04e-02	1.50e-01
Synthesis,-secretion,-and-deacylation-of-Ghrelin	15	1.28e-02	5.88e-02	0.40400	1.13e-01	-0.388000	4.47e-01	9.33e-03
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT)	28	1.56e-02	6.84e-02	0.40300	3.07e-01	-0.260000	4.88e-03	1.70e-02
RHO-GTPases-Activate-ROCKs	18	4.10e-02	1.36e-01	0.40200	3.43e-01	-0.211000	1.18e-02	1.21e-01
Cargo-trafficking-to-the-periciliary-membrane	49	8.08e-04	6.34e-03	0.40200	-2.68e-01	0.299000	1.18e-03	2.87e-04
Receptor-type-tyrosine-protein-phosphatases	19	9.92e-04	7.46e-03	0.40100	3.97e-01	-0.058200	2.76e-03	6.60e-01
APC/C:Cdc20-mediated-degradation-of-Cyclin-B	23	3.67e-02	1.27e-01	0.40100	2.73e-01	-0.293000	2.34e-02	1.49e-02
MET-receptor-recycling	10	7.04e-02	1.91e-01	0.39900	-3.79e-01	0.126000	3.80e-02	4.89e-01
Abacavir-transport-and-metabolism	10	1.35e-01	2.94e-01	0.39900	-1.81e-01	0.355000	3.22e-01	5.17e-02
Josephin-domain-DUBs	10	1.65e-01	3.33e-01	0.39700	-3.43e-01	0.200000	6.01e-02	2.73e-01
Platelet-calcium-homeostasis	27	3.67e-04	3.32e-03	0.39700	3.84e-01	-0.103000	5.57e-04	3.56e-01
Mitotic-Telophase/Cytokinesis	13	1.17e-02	5.45e-02	0.39700	6.79e-02	-0.391000	6.72e-01	1.46e-02
Termination-of-O-glycan-biosynthesis	19	7.35e-03	3.73e-02	0.39500	3.74e-01	-0.125000	4.72e-03	3.45e-01
Mitochondrial-protein-import	60	9.07e-05	1.05e-03	0.39500	2.29e-01	-0.322000	2.17e-03	1.62e-05
Cohesin-Loading-onto-Chromatin	10	1.54e-03	1.05e-02	0.39500	-1.47e-01	-0.366000	4.21e-01	4.49e-02
Ras-activation-upon-Ca2+-influx-through-NMDA-receptor	20	5.11e-02	1.55e-01	0.39000	3.14e-01	-0.231000	1.50e-02	7.36e-02
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle	52	3.74e-04	3.36e-03	0.38900	2.23e-01	-0.318000	5.34e-03	7.15e-05
Heparan-sulfate/heparin-(HS-GAG)-metabolism	50	2.92e-06	8.01e-05	0.38900	-1.20e-01	0.370000	1.43e-01	6.04e-06
IRAK2-mediated-activation-of-TAK1-complex-upon-TLR7/8-or-9-stimulation	14	8.70e-02	2.15e-01	0.38600	1.89e-01	-0.336000	2.21e-01	2.93e-02
Pyrimidine-catabolism	12	1.38e-01	2.95e-01	0.38500	1.99e-01	-0.330000	2.32e-01	4.80e-02
Adenylate-cyclase-activating-pathway	10	1.67e-01	3.35e-01	0.38500	-1.83e-01	0.339000	3.17e-01	6.35e-02
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers	42	4.05e-03	2.34e-02	0.38300	-2.79e-01	0.263000	1.74e-03	3.22e-03
Prolactin-receptor-signaling	10	2.13e-02	8.64e-02	0.38000	-3.80e-01	0.015500	3.76e-02	9.32e-01
N-Glycan-antennae-elongation	14	4.76e-02	1.49e-01	0.37900	3.53e-01	-0.138000	2.21e-02	3.71e-01
Mucopolysaccharidoses	11	1.36e-01	2.94e-01	0.37900	-3.38e-01	0.172000	5.24e-02	3.24e-01
Biotin-transport-and-metabolism	11	2.45e-01	4.21e-01	0.37800	-2.62e-01	0.273000	1.32e-01	1.17e-01
Heme-biosynthesis	14	1.67e-01	3.35e-01	0.37800	-2.75e-01	0.259000	7.48e-02	9.28e-02
Neurotoxicity-of-clostridium-toxins	10	2.38e-01	4.14e-01	0.37600	2.15e-01	-0.309000	2.40e-01	9.03e-02
Condensation-of-Prophase-Chromosomes	14	1.34e-01	2.91e-01	0.37600	3.10e-01	-0.213000	4.48e-02	1.68e-01
Synthesis,-secretion,-and-inactivation-of-Glucose-dependent-Insulinotropic-Polypeptide-(GIP)	11	6.34e-03	3.32e-02	0.37500	-4.45e-02	-0.372000	7.98e-01	3.26e-02
Beta-oxidation-of-very-long-chain-fatty-acids	11	1.12e-03	8.23e-03	0.37200	-1.81e-01	-0.325000	2.98e-01	6.20e-02
Aberrant-regulation-of-mitotic-G1/S-transition-in-cancer-due-to-RB1-defects	17	2.20e-02	8.79e-02	0.36900	3.50e-01	-0.119000	1.25e-02	3.97e-01
Defective-binding-of-RB1-mutants-to-E2F1,(E2F2,-E2F3)	17	2.20e-02	8.79e-02	0.36900	3.50e-01	-0.119000	1.25e-02	3.97e-01
Synthesis-of-very-long-chain-fatty-acyl-CoAs	21	5.50e-02	1.64e-01	0.36900	2.09e-01	-0.304000	9.73e-02	1.60e-02
Cytosolic-iron-sulfur-cluster-assembly	11	3.53e-03	2.09e-02	0.36800	3.56e-01	0.094800	4.09e-02	5.86e-01
The-role-of-Nef-in-HIV-1-replication-and-disease-pathogenesis	27	7.75e-03	3.85e-02	0.36800	-1.58e-01	0.333000	1.56e-01	2.75e-03
Chemokine-receptors-bind-chemokines	42	6.12e-03	3.22e-02	0.36800	-2.49e-01	0.271000	5.17e-03	2.39e-03
G1/S-DNA-Damage-Checkpoints	64	3.19e-06	8.58e-05	0.36700	1.39e-01	-0.340000	5.40e-02	2.51e-06
Gamma-carboxylation-of-protein-precursors	10	8.13e-02	2.07e-01	0.36700	-9.38e-02	0.354000	6.07e-01	5.22e-02
Translation	255	1.99e-15	1.02e-13	0.36700	2.13e-01	-0.298000	4.53e-09	2.01e-16
Disorders-of-Developmental-Biology	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Disorders-of-Nervous-System-Development	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Loss-of-function-of-MECP2-in-Rett-syndrome	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Pervasive-developmental-disorders	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
CDT1-association-with-the-CDC6:ORC:origin-complex	57	1.85e-06	5.37e-05	0.36300	1.04e-01	-0.348000	1.73e-01	5.49e-06
Regulation-of-FOXO-transcriptional-activity-by-acetylation	10	5.92e-02	1.73e-01	0.36200	6.31e-02	-0.356000	7.30e-01	5.10e-02
Interleukin-receptor-SHC-signaling	25	3.03e-02	1.12e-01	0.36100	-1.93e-01	0.305000	9.41e-02	8.35e-03
Signaling-by-SCF-KIT	42	5.16e-03	2.84e-02	0.36000	-2.17e-01	0.288000	1.52e-02	1.23e-03
Cyclin-A/B1/B2-associated-events-during-G2/M-transition	24	3.83e-02	1.30e-01	0.36000	3.01e-01	-0.198000	1.07e-02	9.32e-02
Phosphorylation-of-the-APC/C	20	9.91e-02	2.37e-01	0.36000	2.61e-01	-0.248000	4.33e-02	5.51e-02
TRAF6-mediated-induction-of-TAK1-complex-within-TLR4-complex	15	1.15e-01	2.60e-01	0.36000	1.85e-01	-0.308000	2.14e-01	3.87e-02
TP53-Regulates-Transcription-of-Caspase-Activators-and-Caspases	11	2.80e-01	4.59e-01	0.35900	-2.63e-01	0.245000	1.31e-01	1.59e-01
Activation-of-APC/C-and-APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	74	1.69e-05	2.95e-04	0.35700	1.76e-01	-0.311000	8.95e-03	3.73e-06
Digestion-and-absorption	15	1.71e-01	3.39e-01	0.35600	2.76e-01	-0.226000	6.45e-02	1.30e-01
p53-Dependent-G1-DNA-Damage-Response	62	7.35e-06	1.56e-04	0.35600	1.30e-01	-0.331000	7.61e-02	6.34e-06
p53-Dependent-G1/S-DNA-damage-checkpoint	62	7.35e-06	1.56e-04	0.35600	1.30e-01	-0.331000	7.61e-02	6.34e-06
Negative-regulation-of-NOTCH4-signaling	51	4.08e-05	5.65e-04	0.35500	1.22e-01	-0.333000	1.31e-01	3.78e-05
mitochondrial-fatty-acid-beta-oxidation-of-saturated-fatty-acids	10	2.56e-03	1.61e-02	0.35400	-2.52e-01	-0.249000	1.68e-01	1.72e-01
APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	73	1.85e-05	3.13e-04	0.35400	1.70e-01	-0.310000	1.19e-02	4.44e-06
CREB1-phosphorylation-through-NMDA-receptor-mediated-activation-of-RAS-signaling	28	2.93e-02	1.09e-01	0.35300	2.90e-01	-0.202000	7.88e-03	6.46e-02
Serotonin-Neurotransmitter-Release-Cycle	18	1.72e-02	7.33e-02	0.35300	3.39e-01	-0.095100	1.26e-02	4.85e-01
Glucose-metabolism	85	3.13e-05	4.63e-04	0.35200	2.85e-01	-0.206000	5.39e-06	1.03e-03
Assembly-of-active-LPL-and-LIPC-lipase-complexes	18	3.59e-02	1.26e-01	0.35100	1.29e-01	-0.326000	3.43e-01	1.65e-02
Cholesterol-biosynthesis	23	3.37e-02	1.22e-01	0.35000	1.67e-01	-0.308000	1.64e-01	1.06e-02
Recognition-of-DNA-damage-by-PCNA-containing-replication-complex	29	2.63e-02	1.01e-01	0.35000	2.89e-01	-0.197000	6.99e-03	6.63e-02
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A	50	7.30e-06	1.56e-04	0.35000	8.23e-02	-0.340000	3.14e-01	3.21e-05
p53-Independent-DNA-Damage-Response	50	7.30e-06	1.56e-04	0.35000	8.23e-02	-0.340000	3.14e-01	3.21e-05
p53-Independent-G1/S-DNA-damage-checkpoint	50	7.30e-06	1.56e-04	0.35000	8.23e-02	-0.340000	3.14e-01	3.21e-05
rRNA-processing-in-the-mitochondrion	19	1.29e-01	2.83e-01	0.34700	2.53e-01	-0.237000	5.58e-02	7.36e-02
Role-of-LAT2/NTAL/LAB-on-calcium-mobilization	24	5.47e-02	1.63e-01	0.34700	-2.84e-01	0.199000	1.60e-02	9.13e-02
Polo-like-kinase-mediated-events	16	1.80e-01	3.51e-01	0.34700	2.50e-01	-0.241000	8.36e-02	9.57e-02
Apoptotic-cleavage-of-cell-adhesion–proteins	10	6.09e-02	1.74e-01	0.34600	3.43e-01	-0.044100	6.00e-02	8.09e-01
APC/C:Cdc20-mediated-degradation-of-Securin	66	7.58e-06	1.58e-04	0.34600	1.28e-01	-0.321000	7.30e-02	6.27e-06
GRB2-events-in-EGFR-signaling	12	2.43e-01	4.19e-01	0.34500	2.02e-01	-0.280000	2.25e-01	9.31e-02
Chk1/Chk2(Cds1)-mediated-inactivation-of-Cyclin-B:Cdk1-complex	12	2.80e-01	4.58e-01	0.34400	2.34e-01	-0.253000	1.61e-01	1.29e-01
Inflammasomes	21	6.76e-02	1.87e-01	0.34400	-1.83e-01	0.292000	1.47e-01	2.07e-02
Vif-mediated-degradation-of-APOBEC3G	49	5.56e-06	1.35e-04	0.34400	6.67e-02	-0.338000	4.19e-01	4.31e-05
SCF(Skp2)-mediated-degradation-of-p27/p21	57	6.08e-05	7.51e-04	0.34300	1.33e-01	-0.317000	8.32e-02	3.48e-05
Triglyceride-biosynthesis	11	2.03e-01	3.77e-01	0.34300	1.60e-01	-0.304000	3.58e-01	8.10e-02
Acyl-chain-remodelling-of-PS	18	1.52e-01	3.14e-01	0.34300	2.42e-01	-0.243000	7.51e-02	7.45e-02
Gamma-carboxylation,-transport,-and-amino-terminal-cleavage-of-proteins	11	1.06e-01	2.47e-01	0.34300	-1.01e-01	0.328000	5.62e-01	5.98e-02
Intraflagellar-transport	34	1.65e-02	7.15e-02	0.34200	-1.91e-01	0.284000	5.39e-02	4.19e-03
Signaling-by-Hippo	20	4.95e-04	4.26e-03	0.34100	-3.39e-01	-0.040300	8.75e-03	7.55e-01
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides	103	6.82e-07	2.15e-05	0.34100	2.99e-01	-0.164000	1.60e-07	3.92e-03
Receptor-Mediated-Mitophagy	11	1.39e-01	2.95e-01	0.33900	1.18e-01	-0.318000	4.99e-01	6.79e-02
Glucuronidation	13	2.61e-01	4.39e-01	0.33800	2.25e-01	-0.252000	1.60e-01	1.15e-01
Ketone-body-metabolism	10	1.45e-01	3.06e-01	0.33800	-3.21e-01	0.104000	7.85e-02	5.70e-01
APC/C:Cdh1-mediated-degradation-of-Cdc20-and-other-APC/C:Cdh1-targeted-proteins-in-late-mitosis/early-G1	72	1.34e-05	2.41e-04	0.33800	1.39e-01	-0.308000	4.12e-02	6.34e-06
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint	71	3.41e-05	4.87e-04	0.33700	1.50e-01	-0.301000	2.85e-02	1.11e-05
Stabilization-of-p53	54	8.61e-06	1.77e-04	0.33600	8.14e-02	-0.326000	3.00e-01	3.36e-05
SLBP-Dependent-Processing-of-Replication-Dependent-Histone-Pre-mRNAs	10	2.81e-01	4.59e-01	0.33600	-2.89e-01	0.171000	1.14e-01	3.48e-01
Regulation-of-RUNX1-Expression-and-Activity	17	1.37e-01	2.94e-01	0.33600	-1.86e-01	0.279000	1.84e-01	4.62e-02
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation	48	9.92e-06	1.94e-04	0.33500	6.03e-02	-0.330000	4.70e-01	7.68e-05
Signaling-by-NTRK3-(TRKC)	17	5.04e-04	4.32e-03	0.33500	3.18e-01	0.106000	2.33e-02	4.49e-01
MAP3K8-(TPL2)-dependent-MAPK1/3-activation	15	6.54e-02	1.83e-01	0.33500	1.10e-01	-0.316000	4.61e-01	3.40e-02
Scavenging-of-heme-from-plasma	23	3.02e-02	1.12e-01	0.33400	-3.04e-01	0.138000	1.16e-02	2.50e-01
Autodegradation-of-the-E3-ubiquitin-ligase-COP1	50	1.48e-05	2.64e-04	0.33200	7.11e-02	-0.325000	3.84e-01	7.05e-05
CDK-mediated-phosphorylation-and-removal-of-Cdc6	70	9.40e-06	1.88e-04	0.33200	1.22e-01	-0.309000	7.74e-02	7.76e-06
APC-Cdc20-mediated-degradation-of-Nek2A	25	8.47e-02	2.13e-01	0.33200	2.44e-01	-0.224000	3.43e-02	5.21e-02
Degradation-of-DVL	55	6.51e-06	1.51e-04	0.33100	7.41e-02	-0.323000	3.42e-01	3.39e-05
Processing-of-Intronless-Pre-mRNAs	17	4.21e-02	1.38e-01	0.33100	-3.16e-01	0.101000	2.43e-02	4.70e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest	18	3.47e-02	1.23e-01	0.33100	3.15e-01	-0.100000	2.06e-02	4.63e-01
Autodegradation-of-Cdh1-by-Cdh1:APC/C	62	2.93e-05	4.38e-04	0.33000	1.16e-01	-0.309000	1.15e-01	2.61e-05
Branched-chain-amino-acid-catabolism	21	8.81e-03	4.29e-02	0.32900	-3.23e-01	0.064100	1.05e-02	6.11e-01
PI3K-events-in-ERBB4-signaling	10	2.33e-01	4.10e-01	0.32800	1.38e-01	-0.298000	4.51e-01	1.03e-01
HIV-elongation-arrest-and-recovery	29	3.43e-02	1.23e-01	0.32700	2.78e-01	-0.173000	9.66e-03	1.08e-01
Pausing-and-recovery-of-HIV-elongation	29	3.43e-02	1.23e-01	0.32700	2.78e-01	-0.173000	9.66e-03	1.08e-01
PIWI-interacting-RNA-(piRNA)-biogenesis	27	6.83e-02	1.88e-01	0.32700	2.54e-01	-0.206000	2.24e-02	6.41e-02
Cdc20:Phospho-APC/C-mediated-degradation-of-Cyclin-A	70	4.96e-05	6.34e-04	0.32700	1.39e-01	-0.295000	4.36e-02	1.92e-05
Translesion-synthesis-by-POLI	16	1.47e-01	3.07e-01	0.32600	2.81e-01	-0.166000	5.19e-02	2.50e-01
RA-biosynthesis-pathway	19	1.38e-01	2.95e-01	0.32600	-2.63e-01	0.192000	4.72e-02	1.47e-01
APC-truncation-mutants-have-impaired-AXIN-binding	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
AXIN-missense-mutants-destabilize-the-destruction-complex	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Signaling-by-AMER1-mutants	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Signaling-by-APC-mutants	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Signaling-by-AXIN-mutants	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Truncations-of-AMER1-destabilize-the-destruction-complex	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
ERBB2-Regulates-Cell-Motility	14	6.13e-02	1.75e-01	0.32500	8.05e-02	-0.314000	6.02e-01	4.16e-02
Degradation-of-AXIN	53	4.69e-05	6.10e-04	0.32300	8.81e-02	-0.311000	2.67e-01	9.12e-05
The-NLRP3-inflammasome	16	9.31e-02	2.27e-01	0.32000	-1.24e-01	0.295000	3.92e-01	4.07e-02
Mitochondrial-Fatty-Acid-Beta-Oxidation	34	1.63e-03	1.11e-02	0.32000	8.39e-02	-0.309000	3.97e-01	1.83e-03
Diseases-associated-with-glycosaminoglycan-metabolism	36	8.05e-03	3.97e-02	0.32000	-1.39e-01	0.288000	1.50e-01	2.78e-03
SUMOylation-of-DNA-methylation-proteins	16	1.80e-01	3.52e-01	0.31800	-2.67e-01	0.173000	6.46e-02	2.32e-01
Mitochondrial-translation-initiation	86	4.64e-04	4.05e-03	0.31700	2.24e-01	-0.224000	3.22e-04	3.24e-04
RHO-GTPases-Activate-NADPH-Oxidases	23	1.26e-01	2.77e-01	0.31600	-2.10e-01	0.236000	8.06e-02	5.02e-02
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA	53	9.72e-06	1.92e-04	0.31600	5.29e-02	-0.312000	5.05e-01	8.68e-05
NIK–>noncanonical-NF-kB-signaling	57	4.48e-06	1.16e-04	0.31600	5.42e-02	-0.311000	4.79e-01	4.79e-05
KSRP-(KHSRP)-binds-and-destabilizes-mRNA	15	2.48e-01	4.25e-01	0.31600	-2.45e-01	0.199000	1.00e-01	1.82e-01
Collagen-chain-trimerization	43	1.52e-03	1.05e-02	0.31500	-1.13e-01	0.294000	1.98e-01	8.58e-04
RHOBTB1-GTPase-cycle	22	1.30e-04	1.40e-03	0.31400	-2.93e-01	-0.113000	1.73e-02	3.58e-01
Mitochondrial-translation-termination	86	5.32e-04	4.51e-03	0.31400	2.20e-01	-0.224000	4.06e-04	3.31e-04
FOXO-mediated-transcription-of-cell-cycle-genes	15	2.62e-01	4.41e-01	0.31400	2.36e-01	-0.207000	1.14e-01	1.65e-01
Dectin-1-mediated-noncanonical-NF-kB-signaling	60	5.21e-06	1.31e-04	0.31300	6.14e-02	-0.306000	4.11e-01	3.98e-05
p130Cas-linkage-to-MAPK-signaling-for-integrins	15	2.64e-01	4.43e-01	0.31200	2.36e-01	-0.203000	1.13e-01	1.72e-01
GRB2:SOS-provides-linkage-to-MAPK-signaling-for-Integrins	15	1.68e-01	3.35e-01	0.31200	2.76e-01	-0.146000	6.45e-02	3.28e-01
Regulation-of-MECP2-expression-and-activity	28	8.36e-02	2.11e-01	0.31100	-2.38e-01	0.200000	2.94e-02	6.67e-02
Pyruvate-metabolism	28	2.74e-02	1.04e-01	0.31100	1.32e-01	-0.281000	2.25e-01	1.00e-02
Transcriptional-regulation-of-testis-differentiation	12	1.88e-01	3.60e-01	0.31000	2.86e-01	-0.120000	8.57e-02	4.72e-01
APC/C-mediated-degradation-of-cell-cycle-proteins	85	6.82e-05	8.29e-04	0.31000	1.52e-01	-0.271000	1.56e-02	1.57e-05
Regulation-of-mitotic-cell-cycle	85	6.82e-05	8.29e-04	0.31000	1.52e-01	-0.271000	1.56e-02	1.57e-05
Amino-acids-regulate-mTORC1	53	1.65e-03	1.11e-02	0.31000	2.76e-01	-0.141000	5.01e-04	7.65e-02
Unblocking-of-NMDA-receptors,-glutamate-binding-and-activation	21	6.01e-02	1.74e-01	0.31000	2.84e-01	-0.125000	2.45e-02	3.21e-01
NF-kB-activation-through-FADD/RIP-1-pathway-mediated-by-caspase-8-and–10	11	1.81e-02	7.63e-02	0.31000	-8.18e-02	-0.299000	6.39e-01	8.64e-02
FCERI-mediated-Ca+2-mobilization	39	3.51e-02	1.24e-01	0.31000	-2.09e-01	0.228000	2.38e-02	1.36e-02
Mitochondrial-translation-elongation	86	6.76e-04	5.50e-03	0.30900	2.21e-01	-0.217000	4.03e-04	5.13e-04
ER-Quality-Control-Compartment-(ERQC)	19	7.63e-02	1.98e-01	0.30900	-2.84e-01	0.122000	3.22e-02	3.56e-01
Downstream-signal-transduction	29	8.25e-02	2.09e-01	0.30900	-2.06e-01	0.230000	5.48e-02	3.19e-02
TRP-channels	24	2.23e-02	8.86e-02	0.30900	2.93e-01	-0.097400	1.30e-02	4.09e-01
Removal-of-aminoterminal-propeptides-from-gamma-carboxylated-proteins	10	9.01e-02	2.21e-01	0.30800	-2.34e-02	0.308000	8.98e-01	9.21e-02
Signaling-by-NOTCH3	48	1.73e-02	7.35e-02	0.30800	-2.13e-01	0.222000	1.06e-02	7.67e-03
Pausing-and-recovery-of-Tat-mediated-HIV-elongation	27	4.46e-02	1.44e-01	0.30700	2.71e-01	-0.144000	1.46e-02	1.94e-01
Tat-mediated-HIV-elongation-arrest-and-recovery	27	4.46e-02	1.44e-01	0.30700	2.71e-01	-0.144000	1.46e-02	1.94e-01
LGI-ADAM-interactions	13	5.83e-03	3.10e-02	0.30700	1.18e-01	0.284000	4.61e-01	7.64e-02
FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis	53	2.54e-05	3.92e-04	0.30700	5.64e-02	-0.302000	4.78e-01	1.45e-04
FCGR3A-mediated-IL10-synthesis	49	1.43e-02	6.41e-02	0.30600	-1.94e-01	0.237000	1.89e-02	4.16e-03
RNA-Polymerase-III-Chain-Elongation	18	2.21e-01	3.95e-01	0.30600	2.26e-01	-0.205000	9.65e-02	1.31e-01
TBC/RABGAPs	43	2.38e-02	9.30e-02	0.30500	2.38e-01	-0.192000	7.02e-03	2.97e-02
IL-6-type-cytokine-receptor-ligand-interactions	16	2.06e-01	3.79e-01	0.30400	-2.56e-01	0.164000	7.59e-02	2.55e-01
NF-kB-is-activated-and-signals-survival	12	2.89e-01	4.65e-01	0.30400	1.56e-01	-0.261000	3.50e-01	1.17e-01
Vpu-mediated-degradation-of-CD4	50	4.41e-05	5.89e-04	0.30400	5.13e-02	-0.299000	5.30e-01	2.50e-04
DCC-mediated-attractive-signaling	13	3.17e-01	4.96e-01	0.30300	-1.83e-01	0.241000	2.53e-01	1.32e-01
CLEC7A-(Dectin-1)-induces-NFAT-activation	11	3.28e-01	5.04e-01	0.30300	2.59e-01	-0.158000	1.37e-01	3.65e-01
Ubiquitin-dependent-degradation-of-Cyclin-D	50	3.08e-04	2.96e-03	0.30300	8.63e-02	-0.290000	2.91e-01	3.83e-04
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint	58	1.64e-04	1.69e-03	0.30300	9.75e-02	-0.286000	1.99e-01	1.60e-04
SEMA3A-Plexin-repulsion-signaling-by-inhibiting-Integrin-adhesion	14	7.60e-03	3.84e-02	0.30200	8.07e-02	0.291000	6.01e-01	5.91e-02
Early-Phase-of-HIV-Life-Cycle	13	1.02e-01	2.43e-01	0.30100	2.93e-01	-0.071000	6.77e-02	6.57e-01
Regulation-of-APC/C-activators-between-G1/S-and-early-anaphase	78	1.29e-04	1.39e-03	0.30100	1.35e-01	-0.269000	3.94e-02	4.03e-05
Mitophagy	28	5.65e-02	1.67e-01	0.30000	1.51e-01	-0.259000	1.66e-01	1.76e-02
SCF-beta-TrCP-mediated-degradation-of-Emi1	53	5.03e-05	6.37e-04	0.29900	5.79e-02	-0.294000	4.66e-01	2.16e-04
DAP12-interactions	33	4.40e-02	1.43e-01	0.29800	-1.60e-01	0.251000	1.11e-01	1.26e-02
Regulation-of-TP53-Degradation	33	7.42e-02	1.98e-01	0.29800	2.09e-01	-0.212000	3.78e-02	3.49e-02
RAS-processing	18	1.11e-01	2.54e-01	0.29700	1.21e-01	-0.271000	3.74e-01	4.62e-02
PKA-activation-in-glucagon-signalling	16	1.79e-01	3.51e-01	0.29600	-1.39e-01	0.262000	3.36e-01	6.97e-02
Binding-and-Uptake-of-Ligands-by-Scavenger-Receptors	50	7.74e-03	3.85e-02	0.29600	-1.53e-01	0.253000	6.04e-02	1.94e-03
Costimulation-by-the-CD28-family	63	3.81e-03	2.22e-02	0.29500	-1.67e-01	0.243000	2.15e-02	8.44e-04
RIPK1-mediated-regulated-necrosis	26	5.72e-02	1.68e-01	0.29500	1.33e-01	-0.263000	2.42e-01	2.02e-02
Regulation-of-necroptotic-cell-death	26	5.72e-02	1.68e-01	0.29500	1.33e-01	-0.263000	2.42e-01	2.02e-02
Erythropoietin-activates-Phosphoinositide-3-kinase-(PI3K)	12	1.74e-02	7.39e-02	0.29400	-2.81e-01	-0.085800	9.14e-02	6.07e-01
Interleukin-15-signaling	13	3.37e-01	5.13e-01	0.29400	-2.35e-01	0.177000	1.42e-01	2.70e-01
Pentose-phosphate-pathway	12	1.61e-02	7.06e-02	0.29400	2.79e-01	0.093200	9.47e-02	5.76e-01
Long-term-potentiation	23	4.59e-02	1.45e-01	0.29200	2.74e-01	-0.101000	2.28e-02	4.02e-01
Transport-of-nucleosides-and-free-purine-and-pyrimidine-bases-across-the-plasma-membrane	10	4.22e-01	5.90e-01	0.29200	2.40e-01	-0.166000	1.89e-01	3.62e-01
Establishment-of-Sister-Chromatid-Cohesion	11	2.13e-02	8.63e-02	0.29200	-1.05e-01	-0.272000	5.46e-01	1.18e-01
Senescence-Associated-Secretory-Phenotype-(SASP)	48	2.29e-02	9.03e-02	0.29100	2.25e-01	-0.185000	6.93e-03	2.65e-02
Separation-of-Sister-Chromatids	167	5.39e-07	1.74e-05	0.29100	1.64e-01	-0.241000	2.46e-04	7.75e-08
Resolution-of-Sister-Chromatid-Cohesion	104	4.25e-04	3.77e-03	0.29000	2.09e-01	-0.201000	2.30e-04	3.99e-04
ROS-sensing-by-NFE2L2	55	7.11e-05	8.50e-04	0.29000	5.73e-02	-0.284000	4.62e-01	2.68e-04
Formation-of-tubulin-folding-intermediates-by-CCT/TriC	20	5.73e-02	1.68e-01	0.28900	-2.76e-01	0.087100	3.28e-02	5.00e-01
Interleukin-1-signaling	96	2.11e-05	3.44e-04	0.28800	1.21e-01	-0.262000	4.08e-02	9.14e-06
Amplification–of-signal-from-unattached–kinetochores-via-a-MAD2–inhibitory-signal	91	9.22e-04	6.97e-03	0.28600	2.24e-01	-0.179000	2.21e-04	3.20e-03
Amplification-of-signal-from-the-kinetochores	91	9.22e-04	6.97e-03	0.28600	2.24e-01	-0.179000	2.21e-04	3.20e-03
Activation-of-SMO	17	2.73e-01	4.52e-01	0.28600	-2.23e-01	0.179000	1.11e-01	2.02e-01
SUMOylation-of-immune-response-proteins	11	4.46e-01	6.16e-01	0.28600	2.11e-01	-0.192000	2.25e-01	2.70e-01
SHC1-events-in-ERBB4-signaling	14	3.41e-01	5.15e-01	0.28500	1.77e-01	-0.224000	2.52e-01	1.47e-01
PINK1-PRKN-Mediated-Mitophagy	21	1.53e-01	3.15e-01	0.28500	1.49e-01	-0.243000	2.37e-01	5.36e-02
DAP12-signaling	28	1.26e-01	2.77e-01	0.28400	-1.83e-01	0.217000	9.32e-02	4.66e-02
RNA-Polymerase-III-Transcription-Initiation-From-Type-3-Promoter	28	4.53e-02	1.44e-01	0.28400	1.17e-01	-0.259000	2.84e-01	1.78e-02
Metabolism-of-amino-acids-and-derivatives	335	1.35e-13	6.06e-12	0.28400	1.47e-01	-0.243000	3.54e-06	1.94e-14
Mitotic-Spindle-Checkpoint	108	3.62e-04	3.29e-03	0.28300	2.16e-01	-0.183000	1.03e-04	9.83e-04
RHO-GTPases-Activate-WASPs-and-WAVEs	35	3.99e-02	1.34e-01	0.28300	1.41e-01	-0.245000	1.48e-01	1.20e-02
Collagen-biosynthesis-and-modifying-enzymes	66	1.14e-04	1.27e-03	0.28300	-8.43e-02	0.270000	2.36e-01	1.48e-04
VxPx-cargo-targeting-to-cilium	20	1.31e-01	2.85e-01	0.28300	-1.27e-01	0.253000	3.27e-01	5.04e-02
Regulation-of-Apoptosis	51	5.54e-05	6.90e-04	0.28200	2.97e-02	-0.281000	7.13e-01	5.24e-04
Metalloprotease-DUBs	19	2.32e-01	4.08e-01	0.28200	1.69e-01	-0.226000	2.01e-01	8.87e-02
Phospholipase-C-mediated-cascade;-FGFR2	13	2.67e-01	4.45e-01	0.28200	1.26e-01	-0.252000	4.33e-01	1.15e-01
EPHB-mediated-forward-signaling	32	1.03e-01	2.44e-01	0.28200	2.05e-01	-0.193000	4.45e-02	5.86e-02
Keratinization	59	1.50e-02	6.66e-02	0.28200	2.09e-01	-0.189000	5.52e-03	1.21e-02
RHOBTB-GTPase-Cycle	32	1.52e-03	1.05e-02	0.28100	-2.80e-01	0.018400	6.02e-03	8.57e-01
Regulation-of-ornithine-decarboxylase-(ODC)	50	7.66e-05	9.01e-04	0.28100	3.01e-02	-0.279000	7.12e-01	6.38e-04
Kinesins	40	1.47e-03	1.03e-02	0.27900	2.74e-01	-0.053500	2.71e-03	5.58e-01
MET-activates-PTK2-signaling	18	3.18e-02	1.16e-01	0.27800	-2.50e-02	0.277000	8.55e-01	4.18e-02
Synthesis-of-PA	34	8.60e-02	2.15e-01	0.27800	2.16e-01	-0.175000	2.90e-02	7.76e-02
Telomere-C-strand-synthesis-initiation	13	4.10e-01	5.80e-01	0.27700	-2.01e-01	0.190000	2.08e-01	2.34e-01
DSCAM-interactions	10	3.18e-01	4.97e-01	0.27700	-1.03e-01	0.257000	5.74e-01	1.59e-01
Nicotinamide-salvaging	18	2.73e-01	4.53e-01	0.27700	1.72e-01	-0.217000	2.06e-01	1.11e-01
Assembly-of-the-pre-replicative-complex	66	5.28e-04	4.50e-03	0.27500	1.00e-01	-0.256000	1.58e-01	3.13e-04
MET-activates-RAP1-and-RAC1	11	1.43e-01	3.03e-01	0.27400	-2.72e-01	0.033700	1.18e-01	8.46e-01
Interleukin-6-family-signaling	23	2.16e-01	3.88e-01	0.27400	-1.93e-01	0.194000	1.10e-01	1.07e-01
Cross-presentation-of-soluble-exogenous-antigens-(endosomes)	48	3.35e-04	3.08e-03	0.27400	4.25e-02	-0.270000	6.10e-01	1.19e-03
Synthesis,-secretion,-and-inactivation-of-Glucagon-like-Peptide-1-(GLP-1)	15	3.03e-02	1.12e-01	0.27300	-2.20e-02	-0.272000	8.83e-01	6.82e-02
Downstream-signaling-events-of-B-Cell-Receptor-(BCR)	79	3.30e-06	8.74e-05	0.27300	4.77e-02	-0.268000	4.63e-01	3.70e-05
Dopamine-Neurotransmitter-Release-Cycle	23	6.85e-02	1.88e-01	0.27100	2.55e-01	-0.092400	3.42e-02	4.43e-01
Glycosaminoglycan-metabolism	113	2.12e-06	6.04e-05	0.27000	-9.19e-02	0.254000	9.13e-02	2.97e-06
Activation-of-NF-kappaB-in-B-cells	65	1.80e-05	3.10e-04	0.26900	3.46e-02	-0.267000	6.29e-01	1.99e-04
Transcriptional-Regulation-by-MECP2	55	1.18e-02	5.46e-02	0.26900	-2.31e-01	0.138000	3.08e-03	7.68e-02
RNA-Polymerase-I-Transcription-Initiation	44	2.64e-02	1.01e-01	0.26800	-1.34e-01	0.232000	1.24e-01	7.64e-03
Negative-regulation-of-FLT3	14	1.43e-01	3.04e-01	0.26800	-2.60e-01	0.063400	9.17e-02	6.81e-01
Processing-of-Capped-Intronless-Pre-mRNA	25	3.47e-02	1.23e-01	0.26800	-2.59e-01	0.067900	2.49e-02	5.57e-01
Regulation-of-beta-cell-development	35	1.04e-01	2.44e-01	0.26700	-2.01e-01	0.175000	3.91e-02	7.25e-02
E2F-mediated-regulation-of-DNA-replication	22	2.48e-01	4.24e-01	0.26500	1.97e-01	-0.178000	1.10e-01	1.48e-01
Trafficking-and-processing-of-endosomal-TLR	12	2.74e-01	4.53e-01	0.26500	9.51e-02	-0.248000	5.68e-01	1.37e-01
SUMOylation-of-intracellular-receptors	30	5.80e-03	3.10e-02	0.26500	-2.64e-01	0.026300	1.23e-02	8.03e-01
Peroxisomal-lipid-metabolism	29	1.07e-04	1.19e-03	0.26500	-2.30e-01	-0.132000	3.21e-02	2.19e-01
Processing-and-activation-of-SUMO	10	5.02e-01	6.62e-01	0.26500	-2.14e-01	0.155000	2.41e-01	3.95e-01
GRB2-events-in-ERBB2-signaling	16	2.39e-01	4.15e-01	0.26400	1.18e-01	-0.237000	4.14e-01	1.01e-01
Lysosphingolipid-and-LPA-receptors	14	1.81e-02	7.63e-02	0.26400	2.47e-01	0.093400	1.09e-01	5.45e-01
Regulation-of-RAS-by-GAPs	66	4.45e-05	5.89e-04	0.26400	4.42e-02	-0.260000	5.34e-01	2.55e-04
Rap1-signalling	14	1.21e-01	2.71e-01	0.26400	-2.60e-01	0.045400	9.22e-02	7.68e-01
EML4-and-NUDC-in-mitotic-spindle-formation	95	1.93e-03	1.26e-02	0.26300	2.08e-01	-0.161000	4.50e-04	6.53e-03
Gamma-carboxylation,-hypusine-formation-and-arylsulfatase-activation	37	2.60e-02	1.01e-01	0.26300	-1.04e-01	0.242000	2.75e-01	1.08e-02
JNK-(c-Jun-kinases)-phosphorylation-and–activation-mediated-by-activated-human-TAK1	17	3.51e-01	5.27e-01	0.26300	1.83e-01	-0.189000	1.92e-01	1.78e-01
Orc1-removal-from-chromatin	68	2.65e-04	2.61e-03	0.26300	7.53e-02	-0.252000	2.83e-01	3.33e-04
Sema3A-PAK-dependent-Axon-repulsion	16	3.82e-02	1.30e-01	0.26200	1.06e-02	0.262000	9.42e-01	6.99e-02
GLI3-is-processed-to-GLI3R-by-the-proteasome	57	8.46e-05	9.87e-04	0.26100	2.78e-02	-0.260000	7.16e-01	6.87e-04
Switching-of-origins-to-a-post-replicative-state	88	1.42e-04	1.51e-03	0.26100	9.72e-02	-0.242000	1.15e-01	8.68e-05
COPI-independent-Golgi-to-ER-retrograde-traffic	31	9.84e-02	2.36e-01	0.26100	2.22e-01	-0.136000	3.21e-02	1.91e-01
Pregnenolone-biosynthesis	12	4.02e-01	5.72e-01	0.26000	1.34e-01	-0.223000	4.23e-01	1.80e-01
Triglyceride-metabolism	31	1.53e-01	3.15e-01	0.26000	1.91e-01	-0.176000	6.52e-02	8.95e-02
PKA-activation	17	1.28e-01	2.82e-01	0.26000	-7.19e-02	0.249000	6.08e-01	7.50e-02
HS-GAG-biosynthesis	28	8.13e-04	6.34e-03	0.25900	6.70e-02	0.250000	5.40e-01	2.18e-02
Downregulation-of-ERBB2:ERBB3-signaling	12	3.92e-01	5.67e-01	0.25900	1.27e-01	-0.225000	4.44e-01	1.77e-01
Lewis-blood-group-biosynthesis	15	1.18e-01	2.66e-01	0.25800	-4.65e-02	0.254000	7.55e-01	8.82e-02
Nuclear-events-stimulated-by-ALK-signaling-in-cancer	17	3.64e-01	5.42e-01	0.25800	1.83e-01	-0.182000	1.90e-01	1.94e-01
PKA-mediated-phosphorylation-of-CREB	19	1.02e-01	2.43e-01	0.25700	-6.93e-02	0.248000	6.01e-01	6.16e-02
Zinc-influx-into-cells-by-the-SLC39-gene-family	10	1.75e-01	3.45e-01	0.25700	1.23e-02	-0.257000	9.46e-01	1.60e-01
Regulation-of-RUNX3-expression-and-activity	52	6.40e-04	5.27e-03	0.25700	4.53e-02	-0.253000	5.72e-01	1.62e-03
Free-fatty-acids-regulate-insulin-secretion	11	5.04e-01	6.64e-01	0.25600	-2.02e-01	0.157000	2.46e-01	3.67e-01
CRMPs-in-Sema3A-signaling	16	6.97e-03	3.56e-02	0.25600	1.90e-01	0.171000	1.88e-01	2.36e-01
Fanconi-Anemia-Pathway	34	1.12e-01	2.55e-01	0.25500	2.07e-01	-0.149000	3.66e-02	1.32e-01
Diseases-associated-with-glycosylation-precursor-biosynthesis	17	1.54e-01	3.17e-01	0.25500	2.43e-01	-0.078200	8.33e-02	5.76e-01
Degradation-of-GLI2-by-the-proteasome	57	3.27e-05	4.76e-04	0.25500	1.88e-03	-0.255000	9.80e-01	8.68e-04
Role-of-phospholipids-in-phagocytosis	36	1.20e-01	2.70e-01	0.25500	-1.68e-01	0.192000	8.15e-02	4.64e-02
Adherens-junctions-interactions	23	4.94e-02	1.52e-01	0.25500	-5.42e-02	0.249000	6.53e-01	3.89e-02
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants	14	1.89e-01	3.60e-01	0.25500	-2.46e-01	0.067300	1.12e-01	6.63e-01
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer	14	1.89e-01	3.60e-01	0.25500	-2.46e-01	0.067300	1.12e-01	6.63e-01
Diseases-associated-with-visual-transduction	12	4.83e-01	6.48e-01	0.25400	1.59e-01	-0.199000	3.41e-01	2.33e-01
Diseases-of-the-neuronal-system	12	4.83e-01	6.48e-01	0.25400	1.59e-01	-0.199000	3.41e-01	2.33e-01
Retinoid-cycle-disease-events	12	4.83e-01	6.48e-01	0.25400	1.59e-01	-0.199000	3.41e-01	2.33e-01
Inactivation-of-APC/C-via-direct-inhibition-of-the-APC/C-complex	21	2.50e-01	4.26e-01	0.25400	2.10e-01	-0.143000	9.58e-02	2.55e-01
Inhibition-of-the-proteolytic-activity-of-APC/C-required-for-the-onset-of-anaphase-by-mitotic-spindle-checkpoint-components	21	2.50e-01	4.26e-01	0.25400	2.10e-01	-0.143000	9.58e-02	2.55e-01
Laminin-interactions	23	8.65e-04	6.64e-03	0.25400	1.83e-01	0.176000	1.29e-01	1.43e-01
Translation-of-Replicase-and-Assembly-of-the-Replication-Transcription-Complex	12	3.21e-01	5.00e-01	0.25400	2.35e-01	-0.096100	1.58e-01	5.64e-01
Signaling-by-FGFR2-in-disease	38	8.65e-02	2.15e-01	0.25400	1.47e-01	-0.207000	1.17e-01	2.70e-02
Reduction-of-cytosolic-Ca++-levels	12	1.25e-01	2.76e-01	0.25400	2.54e-01	-0.008870	1.28e-01	9.58e-01
Defects-in-vitamin-and-cofactor-metabolism	20	2.32e-01	4.08e-01	0.25400	-2.19e-01	0.128000	9.01e-02	3.21e-01
Classical-antibody-mediated-complement-activation	18	1.20e-01	2.70e-01	0.25300	-2.44e-01	0.067200	7.26e-02	6.22e-01
Signaling-by-Activin	13	4.50e-01	6.20e-01	0.25300	2.01e-01	-0.154000	2.09e-01	3.37e-01
Glycerophospholipid-biosynthesis	114	1.43e-03	1.01e-02	0.25300	1.87e-01	-0.171000	5.46e-04	1.64e-03
Golgi-Associated-Vesicle-Biogenesis	55	2.37e-02	9.27e-02	0.25300	1.37e-01	-0.213000	7.82e-02	6.30e-03
Cellular-hexose-transport	19	9.40e-03	4.52e-02	0.25300	2.43e-01	0.069400	6.64e-02	6.01e-01
CD28-dependent-Vav1-pathway	12	5.05e-01	6.64e-01	0.25300	-1.73e-01	0.184000	2.99e-01	2.70e-01
RHO-GTPases-activate-PKNs	32	1.25e-01	2.77e-01	0.25200	2.08e-01	-0.143000	4.16e-02	1.62e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-2-Promoter	27	2.07e-01	3.80e-01	0.25200	1.93e-01	-0.163000	8.29e-02	1.43e-01
Regulation-of-PTEN-gene-transcription	59	2.17e-02	8.75e-02	0.25200	-1.42e-01	0.208000	5.85e-02	5.65e-03
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha	62	2.43e-05	3.81e-04	0.25200	7.08e-03	-0.251000	9.23e-01	6.14e-04
Deactivation-of-the-beta-catenin-transactivating-complex	38	6.35e-02	1.79e-01	0.25100	-1.26e-01	0.218000	1.80e-01	2.02e-02
Integrin-cell-surface-interactions	64	7.60e-04	6.05e-03	0.25100	-6.97e-02	0.241000	3.35e-01	8.62e-04
Blood-group-systems-biosynthesis	17	1.16e-01	2.62e-01	0.25000	-5.29e-02	0.245000	7.06e-01	8.07e-02
Glycolysis	66	5.74e-03	3.08e-02	0.24900	2.22e-01	-0.113000	1.79e-03	1.12e-01
CLEC7A-(Dectin-1)-signaling	97	3.29e-04	3.05e-03	0.24800	1.05e-01	-0.225000	7.42e-02	1.25e-04
Late-endosomal-microautophagy	29	1.95e-01	3.69e-01	0.24800	1.59e-01	-0.190000	1.37e-01	7.72e-02
Regulation-of-TP53-Expression-and-Degradation	34	1.57e-01	3.21e-01	0.24700	1.73e-01	-0.177000	8.01e-02	7.47e-02
Aberrant-regulation-of-mitotic-cell-cycle-due-to-RB1-defects	36	7.21e-02	1.94e-01	0.24700	2.17e-01	-0.119000	2.42e-02	2.17e-01
Listeria-monocytogenes-entry-into-host-cells	18	3.67e-01	5.43e-01	0.24700	-1.87e-01	0.162000	1.70e-01	2.34e-01
RNA-Polymerase-I-Transcription	48	2.98e-02	1.11e-01	0.24700	-1.18e-01	0.217000	1.57e-01	9.25e-03
Mitochondrial-translation	92	6.59e-03	3.40e-02	0.24700	1.67e-01	-0.182000	5.68e-03	2.51e-03
Asymmetric-localization-of-PCP-proteins	62	1.22e-04	1.34e-03	0.24700	2.77e-02	-0.245000	7.06e-01	8.37e-04
Class-I-peroxisomal-membrane-protein-import	20	6.67e-02	1.85e-01	0.24600	3.74e-02	-0.243000	7.72e-01	5.99e-02
Tight-junction-interactions	28	2.15e-01	3.88e-01	0.24600	1.61e-01	-0.186000	1.40e-01	8.88e-02
PI3K-events-in-ERBB2-signaling	16	8.69e-02	2.15e-01	0.24500	1.80e-02	-0.245000	9.01e-01	9.02e-02
Cyclin-E-associated-events-during-G1/S-transition	80	1.26e-03	9.09e-03	0.24500	9.84e-02	-0.224000	1.28e-01	5.34e-04
Hh-mutants-abrogate-ligand-secretion	57	3.42e-05	4.87e-04	0.24400	-1.29e-02	-0.244000	8.66e-01	1.43e-03
TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest	13	3.67e-01	5.43e-01	0.24400	2.19e-01	-0.107000	1.71e-01	5.02e-01
Negative-regulation-of-TCF-dependent-signaling-by-WNT-ligand-antagonists	14	3.34e-01	5.12e-01	0.24400	-1.05e-01	0.220000	4.96e-01	1.54e-01
Regulation-of-glycolysis-by-fructose-2,6-bisphosphate-metabolism	11	2.30e-01	4.06e-01	0.24300	2.40e-01	-0.035100	1.68e-01	8.40e-01
ECM-proteoglycans	51	1.87e-03	1.23e-02	0.24300	-4.67e-02	0.238000	5.64e-01	3.23e-03
Regulation-of-PTEN-stability-and-activity	66	6.16e-04	5.10e-03	0.24200	5.86e-02	-0.235000	4.10e-01	9.61e-04
Metabolism-of-folate-and-pterines	15	2.00e-01	3.75e-01	0.24200	2.33e-01	-0.063600	1.18e-01	6.70e-01
Signaling-by-ERBB2-in-Cancer	25	1.34e-02	6.13e-02	0.24100	-8.99e-03	-0.241000	9.38e-01	3.69e-02
RAF-activation	34	1.58e-01	3.22e-01	0.24100	1.52e-01	-0.188000	1.26e-01	5.82e-02
Diseases-of-mitotic-cell-cycle	38	7.53e-02	1.98e-01	0.24100	2.10e-01	-0.118000	2.49e-02	2.08e-01
RNA-Polymerase-I-Transcription-Termination	28	1.15e-01	2.60e-01	0.24000	-1.02e-01	0.218000	3.52e-01	4.61e-02
Degradation-of-GLI1-by-the-proteasome	57	4.28e-05	5.82e-04	0.24000	-1.51e-02	-0.240000	8.43e-01	1.74e-03
SHC1-events-in-EGFR-signaling	13	4.55e-01	6.25e-01	0.24000	1.31e-01	-0.201000	4.13e-01	2.10e-01
Neurotransmitter-clearance	10	4.79e-01	6.45e-01	0.24000	2.15e-01	-0.107000	2.40e-01	5.58e-01
Positive-epigenetic-regulation-of-rRNA-expression	43	1.04e-01	2.45e-01	0.23900	-1.54e-01	0.183000	8.12e-02	3.74e-02
p75NTR-signals-via-NF-kB	15	2.51e-01	4.27e-01	0.23900	7.94e-02	-0.226000	5.94e-01	1.30e-01
Degradation-of-beta-catenin-by-the-destruction-complex	82	4.80e-03	2.69e-02	0.23900	1.20e-01	-0.207000	5.93e-02	1.21e-03
Hh-mutants-are-degraded-by-ERAD	54	4.76e-05	6.13e-04	0.23900	-2.54e-02	-0.238000	7.46e-01	2.51e-03
Heme-signaling	45	6.95e-03	3.56e-02	0.23900	-2.32e-01	0.056300	7.03e-03	5.13e-01
Signaling-by-FGFR3-fusions-in-cancer	10	2.86e-01	4.62e-01	0.23800	3.85e-02	-0.235000	8.33e-01	1.98e-01
Deadenylation-of-mRNA	24	1.89e-02	7.85e-02	0.23800	-2.38e-01	-0.005810	4.34e-02	9.61e-01
Non-integrin-membrane-ECM-interactions	42	1.42e-02	6.40e-02	0.23800	-6.61e-02	0.229000	4.58e-01	1.04e-02
Activation-of-Matrix-Metalloproteinases	25	8.97e-02	2.20e-01	0.23800	-7.19e-02	0.227000	5.33e-01	4.98e-02
RHO-GTPases-Activate-Formins	115	3.07e-03	1.88e-02	0.23800	1.73e-01	-0.163000	1.35e-03	2.50e-03
ER-Phagosome-pathway	81	4.43e-05	5.89e-04	0.23800	3.89e-02	-0.234000	5.45e-01	2.63e-04
Metabolism-of-cofactors	19	3.19e-01	4.98e-01	0.23700	-2.00e-01	0.127000	1.31e-01	3.37e-01
EPHA-mediated-growth-cone-collapse	14	4.32e-01	6.02e-01	0.23700	2.00e-01	-0.128000	1.96e-01	4.08e-01
Cellular-response-to-hypoxia	71	3.70e-05	5.18e-04	0.23700	1.55e-02	-0.236000	8.21e-01	5.73e-04
RORA-activates-gene-expression	17	1.12e-02	5.28e-02	0.23600	-1.75e-01	-0.158000	2.12e-01	2.58e-01
RNA-Polymerase-I-Promoter-Clearance	47	4.65e-02	1.46e-01	0.23500	-1.14e-01	0.205000	1.77e-01	1.48e-02
Protein-methylation	14	5.03e-01	6.63e-01	0.23500	1.65e-01	-0.167000	2.84e-01	2.80e-01
Regulation-of-HMOX1-expression-and-activity	63	4.11e-05	5.65e-04	0.23400	-6.36e-03	-0.234000	9.30e-01	1.30e-03
Regulation-of-BACH1-activity	10	9.18e-02	2.24e-01	0.23400	-1.04e-01	-0.210000	5.70e-01	2.50e-01
Signaling-by-ERBB2-KD-Mutants	24	3.62e-02	1.26e-01	0.23400	1.81e-02	-0.233000	8.78e-01	4.77e-02
Apoptotic-factor-mediated-response	15	3.24e-02	1.18e-01	0.23400	8.88e-02	0.216000	5.51e-01	1.47e-01
TAK1-activates-NFkB-by-phosphorylation-and-activation-of-IKKs-complex	24	2.88e-01	4.65e-01	0.23400	1.44e-01	-0.184000	2.23e-01	1.18e-01
Triglyceride-catabolism	20	2.52e-01	4.27e-01	0.23400	2.08e-01	-0.106000	1.07e-01	4.12e-01
Signaling-by-ALK	26	2.66e-01	4.44e-01	0.23300	-1.82e-01	0.146000	1.08e-01	1.97e-01
Formation-of-the-cornified-envelope	35	1.80e-01	3.51e-01	0.23300	1.56e-01	-0.173000	1.10e-01	7.57e-02
Mitotic-Anaphase	222	1.86e-05	3.13e-04	0.23300	1.53e-01	-0.176000	8.08e-05	6.17e-06
Regulation-of-FZD-by-ubiquitination	19	3.78e-01	5.53e-01	0.23300	1.44e-01	-0.183000	2.77e-01	1.67e-01
Signaling-by-ERBB2-TMD/JMD-mutants	21	1.36e-01	2.94e-01	0.23300	6.73e-02	-0.223000	5.94e-01	7.70e-02
VEGFR2-mediated-cell-proliferation	19	2.81e-01	4.59e-01	0.23200	2.06e-01	-0.107000	1.20e-01	4.20e-01
Phase-2—plateau-phase	15	2.28e-02	9.03e-02	0.23100	1.80e-01	0.145000	2.28e-01	3.29e-01
S33-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
S37-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
S45-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
Signaling-by-CTNNB1-phospho-site-mutants	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
Signaling-by-GSK3beta-mutants	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
T41-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
Signaling-by-NOTCH2	31	2.11e-01	3.83e-01	0.23100	-1.81e-01	0.144000	8.08e-02	1.67e-01
Iron-uptake-and-transport	55	4.77e-02	1.49e-01	0.23100	1.92e-01	-0.128000	1.37e-02	1.00e-01
CS/DS-degradation	13	4.77e-01	6.45e-01	0.23100	-1.24e-01	0.195000	4.39e-01	2.25e-01
Synthesis-of-bile-acids-and-bile-salts	31	8.13e-02	2.07e-01	0.23000	8.25e-02	-0.215000	4.27e-01	3.83e-02
Mitotic-Metaphase-and-Anaphase	223	2.44e-05	3.81e-04	0.23000	1.52e-01	-0.173000	9.34e-05	8.34e-06
HuR-(ELAVL1)-binds-and-stabilizes-mRNA	10	6.24e-01	7.57e-01	0.23000	1.57e-01	-0.168000	3.91e-01	3.58e-01
Signaling-by-EGFR-in-Cancer	23	4.49e-02	1.44e-01	0.22800	1.38e-02	-0.228000	9.09e-01	5.84e-02
MHC-class-II-antigen-presentation	95	3.33e-03	2.00e-02	0.22800	1.98e-01	-0.114000	8.40e-04	5.56e-02
Signaling-by-FLT3-fusion-proteins	19	8.65e-02	2.15e-01	0.22800	2.03e-02	-0.227000	8.78e-01	8.65e-02
Synthesis-of-PIPs-at-the-late-endosome-membrane	11	2.26e-01	4.02e-01	0.22800	-1.25e-02	0.227000	9.43e-01	1.92e-01
Cell-Cycle-Checkpoints	249	1.04e-05	1.97e-04	0.22700	1.53e-01	-0.168000	3.01e-05	4.81e-06
PCNA-Dependent-Long-Patch-Base-Excision-Repair	21	7.36e-02	1.97e-01	0.22700	2.26e-01	-0.024600	7.30e-02	8.45e-01
Prefoldin-mediated-transfer-of-substrate–to-CCT/TriC	24	6.05e-03	3.20e-02	0.22700	-2.12e-01	-0.082100	7.23e-02	4.86e-01
Defective-CFTR-causes-cystic-fibrosis	59	5.49e-06	1.35e-04	0.22700	-7.31e-02	-0.215000	3.31e-01	4.35e-03
Zinc-transporters	17	2.57e-02	9.95e-02	0.22700	-8.74e-02	-0.209000	5.33e-01	1.36e-01
Activated-NOTCH1-Transmits-Signal-to-the-Nucleus	30	1.88e-01	3.60e-01	0.22600	-1.92e-01	0.120000	6.85e-02	2.56e-01
Phase-0—rapid-depolarisation	29	2.75e-02	1.04e-01	0.22600	2.25e-01	-0.023000	3.62e-02	8.30e-01
G0-and-Early-G1	26	2.99e-01	4.76e-01	0.22500	1.71e-01	-0.147000	1.31e-01	1.96e-01
Acyl-chain-remodelling-of-PE	21	3.67e-01	5.43e-01	0.22500	1.77e-01	-0.140000	1.61e-01	2.67e-01
Presynaptic-depolarization-and-calcium-channel-opening	12	2.37e-01	4.14e-01	0.22500	2.24e-01	-0.026900	1.80e-01	8.72e-01
Diseases-associated-with-the-TLR-signaling-cascade	29	2.04e-01	3.77e-01	0.22500	1.20e-01	-0.191000	2.64e-01	7.54e-02
Diseases-of-Immune-System	29	2.04e-01	3.77e-01	0.22500	1.20e-01	-0.191000	2.64e-01	7.54e-02
IRAK4-deficiency-(TLR2/4)	17	3.82e-01	5.58e-01	0.22500	1.16e-01	-0.193000	4.08e-01	1.68e-01
Glucagon-signaling-in-metabolic-regulation	30	6.25e-02	1.77e-01	0.22500	-5.99e-02	0.217000	5.70e-01	3.99e-02
Cyclin-A:Cdk2-associated-events-at-S-phase-entry	82	4.69e-03	2.65e-02	0.22500	9.87e-02	-0.202000	1.22e-01	1.56e-03
RAC2-GTPase-cycle	86	5.11e-03	2.82e-02	0.22400	-1.05e-01	0.198000	9.34e-02	1.49e-03
Synthesis-of-IP2,-IP,-and-Ins-in-the-cytosol	14	7.43e-02	1.98e-01	0.22400	5.27e-02	0.218000	7.33e-01	1.59e-01
Deposition-of-new-CENPA-containing-nucleosomes-at-the-centromere	25	3.28e-01	5.04e-01	0.22400	1.53e-01	-0.163000	1.84e-01	1.59e-01
Nucleosome-assembly	25	3.28e-01	5.04e-01	0.22400	1.53e-01	-0.163000	1.84e-01	1.59e-01
Metal-ion-SLC-transporters	26	4.68e-02	1.47e-01	0.22100	2.41e-02	-0.220000	8.32e-01	5.21e-02
NRIF-signals-cell-death-from-the-nucleus	15	4.66e-01	6.37e-01	0.22100	1.22e-01	-0.184000	4.13e-01	2.17e-01
Post-NMDA-receptor-activation-events	61	7.76e-03	3.85e-02	0.22000	2.09e-01	-0.070800	4.83e-03	3.38e-01
Stimuli-sensing-channels	93	3.27e-05	4.76e-04	0.22000	2.18e-01	-0.030200	2.76e-04	6.15e-01
Transport-of-bile-salts-and-organic-acids,-metal-ions-and-amine-compounds	80	2.72e-02	1.04e-01	0.22000	1.39e-01	-0.171000	3.21e-02	8.16e-03
RHOD-GTPase-cycle	53	4.53e-02	1.44e-01	0.22000	-1.04e-01	0.194000	1.89e-01	1.47e-02
cGMP-effects	15	5.01e-01	6.62e-01	0.22000	1.74e-01	-0.135000	2.44e-01	3.66e-01
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes	29	3.71e-02	1.28e-01	0.22000	2.67e-02	-0.218000	8.03e-01	4.21e-02
Signalling-to-RAS	20	1.45e-01	3.06e-01	0.22000	-4.79e-02	0.214000	7.11e-01	9.69e-02
Peroxisomal-protein-import	62	2.78e-05	4.25e-04	0.22000	-2.16e-01	-0.039900	3.25e-03	5.86e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-1-Promoter	28	2.58e-01	4.36e-01	0.21900	1.80e-01	-0.126000	9.99e-02	2.48e-01
Incretin-synthesis,-secretion,-and-inactivation	17	4.81e-02	1.49e-01	0.21900	-5.22e-02	-0.213000	7.09e-01	1.28e-01
Adrenaline,noradrenaline-inhibits-insulin-secretion	27	5.38e-02	1.61e-01	0.21900	2.16e-01	-0.031800	5.17e-02	7.75e-01
TGF-beta-receptor-signaling-in-EMT-(epithelial-to-mesenchymal-transition)	14	5.40e-01	6.91e-01	0.21800	1.68e-01	-0.140000	2.77e-01	3.66e-01
Glucagon-like-Peptide-1-(GLP1)-regulates-insulin-secretion	39	3.10e-02	1.13e-01	0.21700	2.10e-01	-0.053300	2.32e-02	5.65e-01
TP53-Regulates-Transcription-of-Cell-Cycle-Genes	46	4.69e-02	1.47e-01	0.21700	1.99e-01	-0.085600	1.95e-02	3.15e-01
Extracellular-matrix-organization	274	3.06e-12	1.26e-10	0.21700	-4.23e-02	0.212000	2.27e-01	1.35e-09
Mismatch-repair-(MMR)-directed-by-MSH2:MSH3-(MutSbeta)	13	8.71e-02	2.15e-01	0.21600	2.04e-01	0.070600	2.02e-01	6.59e-01
Cytoprotection-by-HMOX1	118	6.40e-06	1.51e-04	0.21600	3.58e-02	-0.213000	5.02e-01	6.57e-05
Bile-acid-and-bile-salt-metabolism	39	4.46e-02	1.44e-01	0.21500	6.44e-02	-0.206000	4.86e-01	2.63e-02
SLC-mediated-transmembrane-transport	232	1.26e-05	2.32e-04	0.21500	1.81e-01	-0.117000	2.09e-06	2.09e-03
Golgi-Cisternae-Pericentriolar-Stack-Reorganization	14	5.60e-01	7.05e-01	0.21400	1.43e-01	-0.160000	3.53e-01	3.01e-01
NCAM1-interactions	36	9.52e-03	4.55e-02	0.21400	-3.90e-04	0.214000	9.97e-01	2.59e-02
FGFR1-ligand-binding-and-activation	10	6.07e-01	7.44e-01	0.21400	-1.82e-01	0.114000	3.20e-01	5.34e-01
Sema4D-induced-cell-migration-and-growth-cone-collapse	19	1.52e-01	3.15e-01	0.21400	2.11e-01	-0.037400	1.11e-01	7.78e-01
Protein-protein-interactions-at-synapses	82	9.40e-06	1.88e-04	0.21400	2.14e-01	0.014400	8.11e-04	8.21e-01
DARPP-32-events	23	3.35e-01	5.13e-01	0.21400	1.78e-01	-0.119000	1.39e-01	3.24e-01
Metabolism-of-polyamines	58	8.28e-04	6.43e-03	0.21300	7.34e-03	-0.213000	9.23e-01	4.93e-03
Synthesis-of-bile-acids-and-bile-salts-via-7alpha-hydroxycholesterol	21	7.52e-02	1.98e-01	0.21300	6.25e-03	-0.213000	9.60e-01	9.07e-02
Beta-catenin-phosphorylation-cascade	17	1.38e-01	2.95e-01	0.21300	2.12e-01	-0.013600	1.29e-01	9.23e-01
Aberrant-regulation-of-mitotic-exit-in-cancer-due-to-RB1-defects	20	4.42e-01	6.12e-01	0.21300	1.42e-01	-0.158000	2.71e-01	2.20e-01
Nucleotide-salvage	22	3.98e-01	5.70e-01	0.21300	1.35e-01	-0.164000	2.72e-01	1.83e-01
Circadian-Clock	64	7.07e-05	8.50e-04	0.21300	-2.71e-02	-0.211000	7.08e-01	3.51e-03
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex	15	4.18e-01	5.87e-01	0.21100	9.24e-02	-0.190000	5.35e-01	2.02e-01
Inactivation-of-CSF3-(G-CSF)-signaling	22	1.64e-02	7.11e-02	0.21100	-1.94e-01	-0.082800	1.16e-01	5.01e-01
RND2-GTPase-cycle	42	4.51e-02	1.44e-01	0.21000	-6.59e-02	0.200000	4.60e-01	2.52e-02
Interleukin-1-family-signaling	130	6.94e-04	5.62e-03	0.21000	9.43e-02	-0.188000	6.33e-02	2.16e-04
RHOF-GTPase-cycle	41	2.00e-01	3.75e-01	0.21000	-1.49e-01	0.148000	9.93e-02	1.00e-01
Signaling-by-FGFR3-in-disease	20	2.40e-01	4.16e-01	0.21000	6.89e-02	-0.198000	5.94e-01	1.25e-01
Signaling-by-FGFR3-point-mutants-in-cancer	20	2.40e-01	4.16e-01	0.21000	6.89e-02	-0.198000	5.94e-01	1.25e-01
DNA-Damage-Bypass	46	1.38e-01	2.95e-01	0.21000	1.69e-01	-0.124000	4.70e-02	1.47e-01
Nucleobase-biosynthesis	15	1.61e-01	3.27e-01	0.21000	2.10e-01	-0.002590	1.60e-01	9.86e-01
ROS-and-RNS-production-in-phagocytes	35	1.85e-02	7.74e-02	0.20900	2.09e-01	-0.011000	3.27e-02	9.10e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH6-(MutSalpha)	13	9.75e-02	2.35e-01	0.20900	1.95e-01	0.074800	2.24e-01	6.40e-01
Epigenetic-regulation-of-gene-expression	85	3.65e-02	1.27e-01	0.20900	-1.41e-01	0.154000	2.50e-02	1.41e-02
p75NTR-recruits-signalling-complexes	12	1.99e-01	3.75e-01	0.20800	-1.47e-02	-0.208000	9.30e-01	2.12e-01
ERBB2-Activates-PTK6-Signaling	13	2.04e-01	3.77e-01	0.20800	-3.85e-04	-0.208000	9.98e-01	1.94e-01
Activation-of-RAC1	13	3.06e-01	4.84e-01	0.20800	-2.04e-01	0.038800	2.03e-01	8.09e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-GG-NER	24	5.95e-02	1.74e-01	0.20700	2.07e-01	-0.004800	7.85e-02	9.68e-01
DNA-Replication-Pre-Initiation	82	4.15e-03	2.38e-02	0.20700	7.24e-02	-0.194000	2.57e-01	2.33e-03
Aflatoxin-activation-and-detoxification	16	4.95e-01	6.57e-01	0.20700	-1.17e-01	0.171000	4.19e-01	2.36e-01
Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements	85	1.45e-04	1.53e-03	0.20700	2.11e-02	-0.206000	7.36e-01	1.02e-03
Synthesis-of-DNA	117	2.91e-03	1.79e-02	0.20700	1.01e-01	-0.180000	5.79e-02	7.49e-04
Dual-Incision-in-GG-NER	40	7.17e-03	3.65e-02	0.20700	2.07e-01	0.003680	2.36e-02	9.68e-01
Resolution-of-Abasic-Sites-(AP-sites)	37	1.07e-02	5.06e-02	0.20700	2.07e-01	0.002800	2.95e-02	9.77e-01
Regulated-proteolysis-of-p75NTR	11	5.09e-01	6.66e-01	0.20700	1.90e-01	-0.080400	2.74e-01	6.44e-01
MAPK6/MAPK4-signaling	85	7.64e-04	6.05e-03	0.20600	4.56e-02	-0.201000	4.67e-01	1.33e-03
Netrin-1-signaling	48	5.52e-02	1.64e-01	0.20600	-8.06e-02	0.189000	3.34e-01	2.33e-02
DNA-Replication	124	3.76e-03	2.20e-02	0.20500	1.09e-01	-0.173000	3.55e-02	8.59e-04
Assembly-of-collagen-fibrils-and-other-multimeric-structures	56	1.50e-04	1.57e-03	0.20400	5.22e-02	0.197000	4.99e-01	1.06e-02
Growth-hormone-receptor-signaling	19	6.19e-02	1.76e-01	0.20400	-3.75e-02	-0.201000	7.77e-01	1.30e-01
Elastic-fibre-formation	39	1.63e-03	1.11e-02	0.20400	6.35e-02	0.194000	4.93e-01	3.62e-02
TNF-receptor-superfamily-(TNFSF)-members-mediating-non-canonical-NF-kB-pathway	17	4.05e-01	5.76e-01	0.20400	-9.06e-02	0.182000	5.18e-01	1.93e-01
Peptide-hormone-metabolism	69	7.58e-02	1.98e-01	0.20400	1.35e-01	-0.152000	5.18e-02	2.87e-02
tRNA-modification-in-the-nucleus-and-cytosol	41	2.12e-01	3.86e-01	0.20400	-1.32e-01	0.155000	1.42e-01	8.68e-02
Ovarian-tumor-domain-proteases	35	2.20e-01	3.94e-01	0.20300	1.12e-01	-0.170000	2.51e-01	8.20e-02
Interleukin-10-signaling	39	2.37e-01	4.14e-01	0.20300	-1.41e-01	0.147000	1.27e-01	1.13e-01
Translesion-Synthesis-by-POLH	18	5.03e-01	6.63e-01	0.20300	1.57e-01	-0.130000	2.50e-01	3.40e-01
Synthesis-of-PC	27	3.69e-01	5.45e-01	0.20300	1.48e-01	-0.140000	1.84e-01	2.08e-01
Plasma-lipoprotein-assembly,-remodeling,-and-clearance	68	3.89e-03	2.26e-02	0.20300	4.55e-02	-0.198000	5.16e-01	4.70e-03
Chondroitin-sulfate-biosynthesis	19	4.80e-01	6.46e-01	0.20300	-1.27e-01	0.159000	3.38e-01	2.32e-01
Ion-channel-transport	167	1.65e-07	5.67e-06	0.20200	2.00e-01	-0.027600	7.78e-06	5.38e-01
Regulation-of-TP53-Activity-through-Acetylation	30	3.25e-01	5.04e-01	0.20200	-1.30e-01	0.155000	2.17e-01	1.43e-01
C-type-lectin-receptors-(CLRs)	129	2.16e-03	1.38e-02	0.20200	9.86e-02	-0.176000	5.29e-02	5.52e-04
Negative-regulation-of-MAPK-pathway	42	1.56e-01	3.20e-01	0.20100	1.06e-01	-0.171000	2.34e-01	5.48e-02
Infection-with-Mycobacterium-tuberculosis	25	3.92e-01	5.67e-01	0.20100	1.28e-01	-0.155000	2.67e-01	1.79e-01
RNA-Polymerase-III-Transcription-Initiation	36	2.46e-01	4.21e-01	0.20100	1.21e-01	-0.161000	2.08e-01	9.54e-02
SUMOylation-of-transcription-cofactors	41	1.45e-01	3.06e-01	0.20100	-1.75e-01	0.099200	5.24e-02	2.72e-01
Regulation-of-PTEN-mRNA-translation	11	6.73e-01	7.97e-01	0.20100	-1.38e-01	0.146000	4.27e-01	4.03e-01
Repression-of-WNT-target-genes	13	1.68e-01	3.35e-01	0.20000	1.98e-01	0.031600	2.17e-01	8.43e-01
Glycogen-synthesis	14	6.00e-01	7.38e-01	0.20000	1.31e-01	-0.151000	3.94e-01	3.28e-01
Resolution-of-AP-sites-via-the-multiple-nucleotide-patch-replacement-pathway	24	1.05e-01	2.47e-01	0.20000	1.98e-01	-0.024600	9.25e-02	8.34e-01
L1CAM-interactions	95	4.64e-04	4.05e-03	0.20000	1.95e-01	-0.041900	9.90e-04	4.80e-01
FCERI-mediated-NF-kB-activation	86	1.18e-05	2.21e-04	0.19900	-2.64e-02	-0.198000	6.73e-01	1.52e-03
Activated-point-mutants-of-FGFR2	12	4.22e-01	5.90e-01	0.19900	5.42e-02	-0.192000	7.45e-01	2.50e-01
Trafficking-of-GluR2-containing-AMPA-receptors	17	5.04e-02	1.55e-01	0.19900	1.75e-01	0.094200	2.10e-01	5.01e-01
RHOC-GTPase-cycle	71	4.91e-03	2.72e-02	0.19900	-4.93e-02	0.193000	4.73e-01	4.94e-03
HCMV-Late-Events	52	8.19e-02	2.07e-01	0.19800	1.75e-01	-0.092600	2.87e-02	2.48e-01
PTK6-Regulates-RHO-GTPases,-RAS-GTPase-and-MAP-kinases	13	3.58e-01	5.34e-01	0.19800	-4.22e-02	0.193000	7.92e-01	2.27e-01
HDR-through-MMEJ-(alt-NHEJ)	10	1.57e-01	3.21e-01	0.19700	1.36e-01	0.143000	4.56e-01	4.34e-01
Mitotic-Prometaphase	182	1.75e-03	1.16e-02	0.19700	1.48e-01	-0.130000	5.81e-04	2.43e-03
HDR-through-Single-Strand-Annealing-(SSA)	37	1.88e-02	7.84e-02	0.19700	1.97e-01	-0.002210	3.84e-02	9.81e-01
M-Phase	339	1.01e-05	1.95e-04	0.19600	1.37e-01	-0.140000	1.33e-05	8.80e-06
CaM-pathway	33	7.22e-02	1.94e-01	0.19600	-3.90e-02	0.192000	6.98e-01	5.58e-02
Calmodulin-induced-events	33	7.22e-02	1.94e-01	0.19600	-3.90e-02	0.192000	6.98e-01	5.58e-02
Signal-transduction-by-L1	21	4.37e-01	6.08e-01	0.19600	1.10e-01	-0.162000	3.82e-01	1.98e-01
Regulation-of-TP53-Activity-through-Association-with-Co-factors	13	5.18e-01	6.75e-01	0.19600	1.77e-01	-0.084300	2.70e-01	5.98e-01
Regulated-Necrosis	47	1.65e-01	3.33e-01	0.19500	1.12e-01	-0.160000	1.83e-01	5.79e-02
NoRC-negatively-regulates-rRNA-expression	44	1.99e-01	3.75e-01	0.19500	-1.17e-01	0.156000	1.80e-01	7.36e-02
Adenylate-cyclase-inhibitory-pathway	13	6.34e-01	7.67e-01	0.19500	-1.24e-01	0.150000	4.39e-01	3.49e-01
Gene-and-protein-expression-by-JAK-STAT-signaling-after-Interleukin-12-stimulation	35	7.78e-02	2.00e-01	0.19400	4.61e-02	-0.189000	6.37e-01	5.30e-02
Toll-Like-Receptor-7/8-(TLR7/8)-Cascade	86	5.15e-02	1.56e-01	0.19400	1.26e-01	-0.148000	4.39e-02	1.75e-02
CDC6-association-with-the-ORC:origin-complex	11	6.91e-01	8.09e-01	0.19400	1.41e-01	-0.133000	4.18e-01	4.44e-01
Abortive-elongation-of-HIV-1-transcript-in-the-absence-of-Tat	23	8.86e-02	2.18e-01	0.19400	1.94e-01	-0.000422	1.08e-01	9.97e-01
Nuclear-signaling-by-ERBB4	31	3.46e-01	5.22e-01	0.19400	1.47e-01	-0.126000	1.56e-01	2.25e-01
Scavenging-by-Class-A-Receptors	18	1.38e-01	2.95e-01	0.19300	6.55e-03	0.193000	9.62e-01	1.56e-01
MyD88-cascade-initiated-on-plasma-membrane	78	7.59e-02	1.98e-01	0.19300	1.33e-01	-0.139000	4.19e-02	3.33e-02
Toll-Like-Receptor-10-(TLR10)-Cascade	78	7.59e-02	1.98e-01	0.19300	1.33e-01	-0.139000	4.19e-02	3.33e-02
Toll-Like-Receptor-5-(TLR5)-Cascade	78	7.59e-02	1.98e-01	0.19300	1.33e-01	-0.139000	4.19e-02	3.33e-02
Vitamin-B5-(pantothenate)-metabolism	16	7.53e-02	1.98e-01	0.19200	-1.72e-01	-0.086100	2.33e-01	5.51e-01
Recycling-of-bile-acids-and-salts	15	3.25e-01	5.04e-01	0.19200	4.04e-02	-0.188000	7.86e-01	2.07e-01
Transport-of-organic-anions	10	4.07e-01	5.78e-01	0.19200	-1.91e-01	0.019000	2.96e-01	9.17e-01
Downregulation-of-ERBB2-signaling	27	4.91e-02	1.52e-01	0.19100	-1.13e-02	-0.191000	9.19e-01	8.57e-02
MAPK3-(ERK1)-activation	10	7.22e-01	8.25e-01	0.19100	-1.34e-01	0.137000	4.64e-01	4.53e-01
Keratan-sulfate-biosynthesis	24	1.94e-01	3.67e-01	0.19100	-4.87e-02	0.185000	6.80e-01	1.17e-01
MyD88:MAL(TIRAP)-cascade-initiated-on-plasma-membrane	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Toll-Like-Receptor-2-(TLR2)-Cascade	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Toll-Like-Receptor-TLR1:TLR2-Cascade	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Toll-Like-Receptor-TLR6:TLR2-Cascade	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
ABC-family-proteins-mediated-transport	97	1.05e-04	1.18e-03	0.19100	1.10e-02	-0.191000	8.52e-01	1.17e-03
ABC-transporter-disorders	76	1.93e-05	3.22e-04	0.19100	-5.76e-02	-0.182000	3.85e-01	6.09e-03
HDACs-deacetylate-histones	31	2.48e-01	4.24e-01	0.19000	-1.69e-01	0.086700	1.04e-01	4.03e-01
FGFR2-mutant-receptor-activation	28	4.01e-01	5.72e-01	0.18900	1.24e-01	-0.143000	2.57e-01	1.90e-01
Erythrocytes-take-up-carbon-dioxide-and-release-oxygen	12	2.38e-01	4.14e-01	0.18900	2.57e-02	0.187000	8.78e-01	2.61e-01
O2/CO2-exchange-in-erythrocytes	12	2.38e-01	4.14e-01	0.18900	2.57e-02	0.187000	8.78e-01	2.61e-01
Creation-of-C4-and-C2-activators	23	2.02e-01	3.76e-01	0.18900	-1.84e-01	0.044200	1.27e-01	7.13e-01
Regulation-of-gene-expression-by-Hypoxia-inducible-Factor	11	6.33e-01	7.67e-01	0.18900	9.34e-02	-0.164000	5.92e-01	3.45e-01
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters	20	8.70e-02	2.15e-01	0.18900	3.00e-02	0.186000	8.17e-01	1.49e-01
Tetrahydrobiopterin-(BH4)-synthesis,-recycling,-salvage-and-regulation	10	2.30e-01	4.06e-01	0.18900	-1.75e-01	-0.069100	3.37e-01	7.05e-01
mRNA-3’-end-processing	54	4.12e-02	1.37e-01	0.18800	-1.79e-01	0.059400	2.30e-02	4.50e-01
Axon-guidance	493	4.10e-08	1.45e-06	0.18800	1.53e-01	-0.109000	5.64e-09	2.99e-05
Pre-NOTCH-Transcription-and-Translation	34	2.02e-01	3.76e-01	0.18700	-7.93e-02	0.170000	4.24e-01	8.64e-02
DDX58/IFIH1-mediated-induction-of-interferon-alpha/beta	61	8.70e-03	4.27e-02	0.18700	2.89e-02	-0.185000	6.96e-01	1.26e-02
PERK-regulates-gene-expression	29	1.37e-01	2.95e-01	0.18700	4.27e-02	-0.182000	6.91e-01	8.99e-02
Transcriptional-regulation-of-pluripotent-stem-cells	24	3.25e-01	5.04e-01	0.18600	7.83e-02	-0.169000	5.06e-01	1.51e-01
Nuclear-Receptor-transcription-pathway	51	7.66e-02	1.98e-01	0.18600	-1.72e-01	0.071100	3.36e-02	3.80e-01
MET-promotes-cell-motility	29	2.30e-01	4.06e-01	0.18600	-7.01e-02	0.172000	5.13e-01	1.09e-01
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2	13	6.59e-01	7.87e-01	0.18600	-1.17e-01	0.144000	4.64e-01	3.69e-01
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity	22	8.03e-02	2.05e-01	0.18600	-1.84e-01	-0.024500	1.35e-01	8.42e-01
Purine-ribonucleoside-monophosphate-biosynthesis	12	3.41e-01	5.15e-01	0.18500	1.85e-01	-0.009460	2.68e-01	9.55e-01
MyD88-dependent-cascade-initiated-on-endosome	85	7.09e-02	1.91e-01	0.18500	1.20e-01	-0.141000	5.62e-02	2.49e-02
PCP/CE-pathway	88	4.54e-04	4.00e-03	0.18400	1.15e-02	-0.184000	8.52e-01	2.84e-03
MyD88-deficiency-(TLR2/4)	16	4.56e-01	6.26e-01	0.18400	7.12e-02	-0.170000	6.22e-01	2.39e-01
Diseases-associated-with-N-glycosylation-of-proteins	16	4.55e-01	6.25e-01	0.18400	-1.70e-01	0.070800	2.39e-01	6.24e-01
Translation-of-Structural-Proteins	28	4.21e-01	5.90e-01	0.18400	-1.20e-01	0.140000	2.72e-01	2.00e-01
Hedgehog-ligand-biogenesis	63	3.59e-04	3.28e-03	0.18400	-4.42e-02	-0.179000	5.44e-01	1.41e-02
VEGFR2-mediated-vascular-permeability	26	4.33e-01	6.02e-01	0.18400	-1.46e-01	0.112000	1.99e-01	3.21e-01
E3-ubiquitin-ligases-ubiquitinate-target-proteins	40	1.26e-01	2.77e-01	0.18400	-1.72e-01	0.065500	5.99e-02	4.73e-01
Nonhomologous-End-Joining-(NHEJ)	34	3.14e-01	4.93e-01	0.18400	-1.05e-01	0.151000	2.88e-01	1.28e-01
EPH-Ephrin-signaling	85	3.60e-02	1.26e-01	0.18400	1.60e-01	-0.090800	1.09e-02	1.48e-01
Constitutive-Signaling-by-Overexpressed-ERBB2	10	2.10e-01	3.83e-01	0.18300	-1.07e-01	-0.149000	5.60e-01	4.15e-01
Metabolic-disorders-of-biological-oxidation-enzymes	32	1.15e-01	2.61e-01	0.18300	3.89e-02	-0.179000	7.03e-01	7.99e-02
Dissolution-of-Fibrin-Clot	12	1.63e-01	3.30e-01	0.18300	-1.57e-01	-0.094400	3.48e-01	5.71e-01
Mismatch-Repair	14	1.09e-01	2.52e-01	0.18300	1.32e-01	0.127000	3.93e-01	4.12e-01
Signaling-by-Erythropoietin	25	1.54e-01	3.17e-01	0.18200	-1.80e-01	0.026800	1.19e-01	8.17e-01
SUMOylation-of-chromatin-organization-proteins	54	1.97e-01	3.72e-01	0.18200	-1.18e-01	0.138000	1.33e-01	7.94e-02
Notch-HLH-transcription-pathway	27	3.52e-01	5.27e-01	0.18100	-8.84e-02	0.158000	4.26e-01	1.54e-01
N-glycan-antennae-elongation-in-the-medial/trans-Golgi	23	2.44e-01	4.21e-01	0.18100	1.75e-01	-0.046500	1.46e-01	7.00e-01
RNA-Polymerase-II-Transcription-Termination	62	2.73e-02	1.04e-01	0.18100	-1.74e-01	0.051400	1.79e-02	4.84e-01
SHC-mediated-cascade:FGFR2	18	4.95e-01	6.57e-01	0.18100	8.71e-02	-0.159000	5.22e-01	2.44e-01
Signaling-by-ERBB2-ECD-mutants	15	1.02e-01	2.43e-01	0.18100	-1.06e-01	-0.146000	4.77e-01	3.27e-01
Constitutive-Signaling-by-Aberrant-PI3K-in-Cancer	71	1.09e-01	2.52e-01	0.18000	-1.44e-01	0.108000	3.60e-02	1.14e-01
Myogenesis	24	4.77e-01	6.45e-01	0.18000	-1.10e-01	0.142000	3.51e-01	2.27e-01
RIP-mediated-NFkB-activation-via-ZBP1	17	5.48e-01	6.93e-01	0.18000	1.53e-01	-0.094400	2.75e-01	5.00e-01
Negative-regulation-of-NMDA-receptor-mediated-neuronal-transmission	21	1.06e-01	2.47e-01	0.17900	1.78e-01	0.023700	1.59e-01	8.51e-01
Neurotransmitter-release-cycle	46	1.75e-01	3.45e-01	0.17900	1.57e-01	-0.086900	6.59e-02	3.07e-01
Protein-localization	156	6.46e-06	1.51e-04	0.17900	1.96e-02	-0.178000	6.73e-01	1.23e-04
Signaling-by-Hedgehog	132	1.86e-03	1.23e-02	0.17900	-1.66e-01	0.065800	9.76e-04	1.91e-01
Viral-Messenger-RNA-Synthesis	42	1.31e-01	2.85e-01	0.17900	1.67e-01	-0.064400	6.17e-02	4.70e-01
Constitutive-Signaling-by-NOTCH1-HD+PEST-Domain-Mutants	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Constitutive-Signaling-by-NOTCH1-PEST-Domain-Mutants	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Signaling-by-NOTCH1-HD+PEST-Domain-Mutants-in-Cancer	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Signaling-by-NOTCH1-PEST-Domain-Mutants-in-Cancer	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Signaling-by-NOTCH1-in-Cancer	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Conversion-from-APC/C:Cdc20-to-APC/C:Cdh1-in-late-anaphase	20	5.47e-01	6.93e-01	0.17800	1.41e-01	-0.110000	2.76e-01	3.95e-01
Synthesis-of-PIPs-at-the-early-endosome-membrane	16	5.26e-01	6.79e-01	0.17800	-8.06e-02	0.159000	5.77e-01	2.71e-01
Antigen-processing-Cross-presentation	95	5.64e-04	4.72e-03	0.17800	1.53e-02	-0.177000	7.97e-01	2.79e-03
TNFR1-induced-proapoptotic-signaling	13	6.31e-01	7.65e-01	0.17700	-1.53e-01	0.090700	3.41e-01	5.71e-01
RND1-GTPase-cycle	41	1.42e-01	3.02e-01	0.17700	-6.45e-02	0.165000	4.75e-01	6.71e-02
Signaling-by-FLT3-ITD-and-TKD-mutants	16	5.58e-01	7.04e-01	0.17700	8.76e-02	-0.154000	5.44e-01	2.86e-01
Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS)	37	1.50e-02	6.67e-02	0.17700	3.81e-02	0.173000	6.89e-01	6.91e-02
Paradoxical-activation-of-RAF-signaling-by-kinase-inactive-BRAF	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Signaling-by-RAS-mutants	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Signaling-by-moderate-kinase-activity-BRAF-mutants	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Signaling-downstream-of-RAS-mutants	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
RHO-GTPases-activate-KTN1	10	7.42e-01	8.41e-01	0.17700	1.40e-01	-0.107000	4.42e-01	5.57e-01
Nervous-system-development	517	2.12e-07	6.99e-06	0.17600	1.42e-01	-0.104000	3.20e-08	4.78e-05
Sensory-processing-of-sound	69	4.17e-02	1.38e-01	0.17600	1.63e-01	-0.064900	1.90e-02	3.51e-01
Cellular-response-to-chemical-stress	151	1.27e-05	2.32e-04	0.17600	1.77e-02	-0.175000	7.07e-01	2.09e-04
Transcriptional-regulation-by-the-AP-2-(TFAP2)-family-of-transcription-factors	32	4.12e-01	5.82e-01	0.17600	1.18e-01	-0.130000	2.48e-01	2.03e-01
Smooth-Muscle-Contraction	36	2.34e-01	4.11e-01	0.17500	-7.62e-02	0.158000	4.29e-01	1.01e-01
Mitochondrial-iron-sulfur-cluster-biogenesis	13	4.90e-01	6.54e-01	0.17500	1.68e-01	-0.049100	2.93e-01	7.59e-01
Fatty-acyl-CoA-biosynthesis	32	2.01e-01	3.76e-01	0.17400	5.60e-02	-0.165000	5.83e-01	1.06e-01
Interactions-of-Vpr-with-host-cellular-proteins	34	2.41e-01	4.17e-01	0.17400	1.59e-01	-0.070800	1.09e-01	4.75e-01
Collagen-degradation	36	2.40e-01	4.16e-01	0.17400	-7.51e-02	0.157000	4.36e-01	1.04e-01
FLT3-Signaling	37	1.56e-01	3.20e-01	0.17300	-1.65e-01	0.054600	8.30e-02	5.66e-01
RHO-GTPase-Effectors	236	1.15e-03	8.47e-03	0.17300	1.38e-01	-0.105000	2.54e-04	5.39e-03
RHOG-GTPase-cycle	72	7.89e-02	2.02e-01	0.17300	-8.47e-02	0.151000	2.14e-01	2.63e-02
RAC3-GTPase-cycle	90	6.29e-02	1.78e-01	0.17300	-9.73e-02	0.143000	1.10e-01	1.87e-02
Molecules-associated-with-elastic-fibres	29	1.09e-01	2.52e-01	0.17300	-1.14e-02	0.172000	9.16e-01	1.08e-01
p38MAPK-events	13	3.52e-01	5.27e-01	0.17300	1.72e-01	-0.005500	2.82e-01	9.73e-01
Negative-epigenetic-regulation-of-rRNA-expression	47	2.43e-01	4.19e-01	0.17200	-9.81e-02	0.142000	2.44e-01	9.24e-02
Collagen-formation	88	2.66e-04	2.61e-03	0.17100	1.65e-02	0.171000	7.89e-01	5.63e-03
RNA-Polymerase-III-Transcription-Termination	23	3.20e-01	4.99e-01	0.17100	5.27e-02	-0.163000	6.62e-01	1.76e-01
FGFR2-ligand-binding-and-activation	14	4.74e-01	6.42e-01	0.17100	4.54e-02	-0.165000	7.69e-01	2.86e-01
RNA-Polymerase-I-Promoter-Escape	28	2.35e-01	4.11e-01	0.17100	-4.80e-02	0.164000	6.60e-01	1.34e-01
TRAF6-mediated-induction-of-NFkB-and-MAP-kinases-upon-TLR7/8-or-9-activation	84	1.07e-01	2.48e-01	0.17000	1.09e-01	-0.131000	8.28e-02	3.84e-02
Signaling-by-high-kinase-activity-BRAF-mutants	34	3.57e-01	5.33e-01	0.17000	1.42e-01	-0.093900	1.51e-01	3.43e-01
PI-3K-cascade:FGFR2	18	2.85e-01	4.62e-01	0.17000	1.82e-02	-0.169000	8.94e-01	2.14e-01
Unwinding-of-DNA	12	2.14e-01	3.88e-01	0.17000	1.49e-01	0.081800	3.71e-01	6.24e-01
RET-signaling	40	3.26e-01	5.04e-01	0.17000	-1.36e-01	0.101000	1.35e-01	2.68e-01
TP53-Regulates-Metabolic-Genes	83	9.15e-02	2.24e-01	0.17000	9.78e-02	-0.139000	1.23e-01	2.88e-02
Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer	43	1.90e-02	7.88e-02	0.16900	-1.69e-01	-0.017300	5.58e-02	8.44e-01
Activation-of-gene-expression-by-SREBF-(SREBP)	40	2.81e-02	1.06e-01	0.16900	-1.31e-02	-0.169000	8.86e-01	6.47e-02
Cellular-responses-to-stress	635	5.02e-09	2.01e-07	0.16900	9.05e-02	-0.143000	9.39e-05	6.95e-10
Signaling-by-FGFR-in-disease	57	3.22e-02	1.17e-01	0.16900	3.17e-02	-0.166000	6.79e-01	3.00e-02
TNFR1-induced-NFkappaB-signaling-pathway	25	5.23e-01	6.78e-01	0.16800	1.28e-01	-0.108000	2.66e-01	3.48e-01
Activation-of-NMDA-receptors-and-postsynaptic-events	74	7.78e-03	3.85e-02	0.16800	1.67e-01	-0.021400	1.32e-02	7.50e-01
Constitutive-Signaling-by-EGFRvIII	15	2.15e-01	3.88e-01	0.16800	-1.64e-01	-0.036400	2.72e-01	8.07e-01
Signaling-by-EGFRvIII-in-Cancer	15	2.15e-01	3.88e-01	0.16800	-1.64e-01	-0.036400	2.72e-01	8.07e-01
Miscellaneous-transport-and-binding-events	23	4.10e-01	5.80e-01	0.16700	-6.81e-02	0.153000	5.72e-01	2.05e-01
Prolonged-ERK-activation-events	14	4.93e-01	6.56e-01	0.16700	-1.61e-01	0.045500	2.98e-01	7.68e-01
MAP2K-and-MAPK-activation	38	3.36e-01	5.13e-01	0.16700	1.38e-01	-0.093000	1.40e-01	3.21e-01
Activated-NTRK2-signals-through-FRS2-and-FRS3	11	4.50e-01	6.20e-01	0.16600	-8.58e-03	0.166000	9.61e-01	3.40e-01
Cellular-responses-to-stimuli	639	8.37e-09	3.18e-07	0.16600	8.91e-02	-0.141000	1.14e-04	1.17e-09
Platelet-Adhesion-to-exposed-collagen	13	3.94e-01	5.68e-01	0.16600	8.99e-03	-0.165000	9.55e-01	3.02e-01
Signaling-by-NOTCH1	72	1.72e-01	3.40e-01	0.16500	-1.12e-01	0.122000	1.00e-01	7.41e-02
Phospholipase-C-mediated-cascade;-FGFR4	12	3.65e-01	5.42e-01	0.16500	-1.15e-02	-0.165000	9.45e-01	3.24e-01
DNA-strand-elongation	32	1.67e-02	7.19e-02	0.16500	1.29e-01	0.103000	2.08e-01	3.13e-01
TP53-Regulates-Transcription-of-DNA-Repair-Genes	57	2.45e-02	9.51e-02	0.16500	1.64e-01	-0.017900	3.24e-02	8.15e-01
Cleavage-of-the-damaged-purine	11	7.20e-01	8.25e-01	0.16400	-8.54e-02	0.140000	6.24e-01	4.20e-01
Depurination	11	7.20e-01	8.25e-01	0.16400	-8.54e-02	0.140000	6.24e-01	4.20e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-purine	11	7.20e-01	8.25e-01	0.16400	-8.54e-02	0.140000	6.24e-01	4.20e-01
Lagging-Strand-Synthesis	20	7.73e-02	2.00e-01	0.16400	1.16e-01	0.116000	3.68e-01	3.70e-01
Keratan-sulfate/keratin-metabolism	29	3.29e-01	5.05e-01	0.16400	-6.44e-02	0.151000	5.48e-01	1.60e-01
RHOV-GTPase-cycle	37	1.82e-01	3.54e-01	0.16400	4.88e-02	-0.156000	6.07e-01	9.99e-02
Synthesis-of-bile-acids-and-bile-salts-via-24-hydroxycholesterol	11	6.78e-01	8.00e-01	0.16300	6.96e-02	-0.147000	6.89e-01	3.97e-01
Activation-of-HOX-genes-during-differentiation	61	2.21e-01	3.95e-01	0.16300	-1.02e-01	0.127000	1.66e-01	8.69e-02
Activation-of-anterior-HOX-genes-in-hindbrain-development-during-early-embryogenesis	61	2.21e-01	3.95e-01	0.16300	-1.02e-01	0.127000	1.66e-01	8.69e-02
Constitutive-Signaling-by-Ligand-Responsive-EGFR-Cancer-Variants	18	1.10e-01	2.53e-01	0.16300	-9.24e-02	-0.134000	4.97e-01	3.25e-01
Signaling-by-Ligand-Responsive-EGFR-Variants-in-Cancer	18	1.10e-01	2.53e-01	0.16300	-9.24e-02	-0.134000	4.97e-01	3.25e-01
Regulation-of-insulin-secretion	75	6.07e-03	3.20e-02	0.16300	1.62e-01	-0.010300	1.50e-02	8.77e-01
Cilium-Assembly	174	5.33e-03	2.92e-02	0.16300	-8.18e-02	0.141000	6.26e-02	1.36e-03
Vitamin-D-(calciferol)-metabolism	11	7.21e-01	8.25e-01	0.16300	8.30e-02	-0.140000	6.33e-01	4.22e-01
Initiation-of-Nuclear-Envelope-(NE)-Reformation	19	1.05e-01	2.47e-01	0.16300	1.41e-01	0.080700	2.87e-01	5.42e-01
Butyrate-Response-Factor-1-(BRF1)-binds-and-destabilizes-mRNA	16	5.82e-01	7.25e-01	0.16200	-1.45e-01	0.072400	3.14e-01	6.16e-01
UCH-proteinases	83	1.53e-03	1.05e-02	0.16200	-6.30e-03	-0.162000	9.21e-01	1.06e-02
Downstream-signaling-of-activated-FGFR2	25	2.65e-01	4.43e-01	0.16200	3.37e-02	-0.158000	7.70e-01	1.71e-01
O-glycosylation-of-TSR-domain-containing-proteins	38	1.86e-02	7.76e-02	0.16100	5.34e-02	0.152000	5.69e-01	1.04e-01
RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs	69	5.56e-03	3.03e-02	0.16100	-3.07e-03	-0.161000	9.65e-01	2.04e-02
Autophagy	125	5.26e-02	1.58e-01	0.16100	1.22e-01	-0.106000	1.85e-02	4.12e-02
Cooperation-of-Prefoldin-and-TriC/CCT–in-actin-and-tubulin-folding	27	5.05e-02	1.55e-01	0.16100	-1.46e-01	-0.066800	1.88e-01	5.48e-01
Leading-Strand-Synthesis	14	2.15e-01	3.88e-01	0.16100	1.47e-01	0.065400	3.42e-01	6.72e-01
Polymerase-switching	14	2.15e-01	3.88e-01	0.16100	1.47e-01	0.065400	3.42e-01	6.72e-01
Sealing-of-the-nuclear-envelope-(NE)-by-ESCRT-III	24	6.89e-02	1.88e-01	0.16100	1.45e-01	0.069300	2.19e-01	5.57e-01
Mitochondrial-calcium-ion-transport	22	5.24e-01	6.78e-01	0.16100	8.09e-02	-0.139000	5.11e-01	2.60e-01
S-Phase	159	1.13e-02	5.32e-02	0.16100	8.40e-02	-0.137000	6.72e-02	2.89e-03
Oncogenic-MAPK-signaling	79	8.72e-02	2.15e-01	0.16000	7.64e-02	-0.141000	2.40e-01	3.02e-02
FRS-mediated-FGFR2-signaling	20	5.45e-01	6.92e-01	0.16000	7.79e-02	-0.140000	5.46e-01	2.78e-01
Ub-specific-processing-proteases	158	3.16e-03	1.92e-02	0.16000	6.26e-02	-0.147000	1.74e-01	1.39e-03
Metabolism-of-steroids	139	1.25e-03	9.03e-03	0.16000	3.99e-02	-0.155000	4.17e-01	1.60e-03
TNFR2-non-canonical-NF-kB-pathway	94	4.01e-03	2.32e-02	0.16000	2.17e-02	-0.158000	7.16e-01	7.90e-03
Cytochrome-c-mediated-apoptotic-response	11	3.17e-01	4.96e-01	0.16000	5.63e-02	0.150000	7.46e-01	3.90e-01
Negative-regulation-of-FGFR2-signaling	28	5.31e-01	6.84e-01	0.15900	1.14e-01	-0.111000	2.94e-01	3.10e-01
Mitotic-G2-G2/M-phases	178	1.38e-02	6.27e-02	0.15900	9.65e-02	-0.126000	2.61e-02	3.64e-03
Signaling-by-VEGF	100	1.03e-01	2.44e-01	0.15900	-1.19e-01	0.105000	3.98e-02	6.86e-02
RHOQ-GTPase-cycle	59	1.99e-01	3.74e-01	0.15900	-8.37e-02	0.135000	2.66e-01	7.32e-02
Toll-Like-Receptor-4-(TLR4)-Cascade	124	3.81e-02	1.30e-01	0.15800	8.63e-02	-0.133000	9.67e-02	1.07e-02
Regulation-of-TP53-Activity-through-Methylation	17	4.42e-01	6.12e-01	0.15800	1.54e-01	-0.037900	2.73e-01	7.87e-01
Platelet-homeostasis	83	4.66e-03	2.65e-02	0.15800	1.58e-01	-0.009010	1.30e-02	8.87e-01
Macroautophagy	111	7.82e-02	2.01e-01	0.15800	1.22e-01	-0.100000	2.67e-02	6.73e-02
FGFR3-ligand-binding-and-activation	11	7.12e-01	8.19e-01	0.15800	-1.40e-01	0.072600	4.21e-01	6.76e-01
FGFR3c-ligand-binding-and-activation	11	7.12e-01	8.19e-01	0.15800	-1.40e-01	0.072600	4.21e-01	6.76e-01
Sema4D-in-semaphorin-signaling	23	1.70e-01	3.38e-01	0.15800	1.57e-01	0.011400	1.92e-01	9.25e-01
Signaling-by-BMP	26	5.55e-02	1.64e-01	0.15700	-7.93e-02	-0.136000	4.84e-01	2.31e-01
Recycling-pathway-of-L1	27	7.08e-02	1.91e-01	0.15700	1.49e-01	0.049600	1.80e-01	6.56e-01
InlB-mediated-entry-of-Listeria-monocytogenes-into-host-cell	14	4.48e-01	6.18e-01	0.15700	-1.56e-01	0.020200	3.13e-01	8.96e-01
Clathrin-mediated-endocytosis	134	4.68e-02	1.47e-01	0.15700	9.88e-02	-0.122000	4.82e-02	1.47e-02
NOTCH3-Activation-and-Transmission-of-Signal-to-the-Nucleus	24	4.78e-01	6.45e-01	0.15700	-1.39e-01	0.071300	2.37e-01	5.46e-01
Signaling-by-RAF1-mutants	39	4.00e-01	5.70e-01	0.15600	9.36e-02	-0.125000	3.12e-01	1.77e-01
Glycosphingolipid-metabolism	39	2.97e-01	4.74e-01	0.15600	-6.91e-02	0.140000	4.55e-01	1.31e-01
Reproduction	75	1.78e-01	3.49e-01	0.15600	1.23e-01	-0.095100	6.50e-02	1.54e-01
G2/M-Checkpoints	130	3.36e-02	1.22e-01	0.15600	8.27e-02	-0.132000	1.03e-01	9.40e-03
TICAM1-dependent-activation-of-IRF3/IRF7	11	3.12e-01	4.91e-01	0.15600	-1.39e-01	-0.070500	4.26e-01	6.86e-01
MECP2-regulates-neuronal-receptors-and-channels	17	2.51e-01	4.27e-01	0.15600	-1.54e-01	-0.021900	2.72e-01	8.76e-01
G-beta:gamma-signalling-through-CDC42	19	3.27e-01	5.04e-01	0.15500	1.55e-01	-0.015600	2.43e-01	9.06e-01
SUMOylation-of-transcription-factors	18	4.40e-01	6.10e-01	0.15500	-3.83e-02	0.150000	7.79e-01	2.70e-01
Activation-of-PPARGC1A-(PGC-1alpha)-by-phosphorylation	10	6.69e-01	7.94e-01	0.15400	-4.77e-02	0.147000	7.94e-01	4.21e-01
RAF-independent-MAPK1/3-activation	23	1.85e-01	3.59e-01	0.15400	-1.54e-01	-0.010500	2.01e-01	9.30e-01
Resolution-of-D-loop-Structures-through-Synthesis-Dependent-Strand-Annealing-(SDSA)	26	7.63e-02	1.98e-01	0.15400	1.43e-01	0.058300	2.08e-01	6.07e-01
Interleukin-20-family-signaling	19	5.23e-01	6.78e-01	0.15400	-1.42e-01	0.059300	2.85e-01	6.54e-01
Glutamate-binding,-activation-of-AMPA-receptors-and-synaptic-plasticity	30	4.22e-02	1.38e-01	0.15300	1.33e-01	0.076900	2.09e-01	4.66e-01
Trafficking-of-AMPA-receptors	30	4.22e-02	1.38e-01	0.15300	1.33e-01	0.076900	2.09e-01	4.66e-01
G2/M-Transition	176	1.67e-02	7.19e-02	0.15300	8.87e-02	-0.125000	4.22e-02	4.26e-03
BMAL1:CLOCK,NPAS2-activates-circadian-gene-expression	25	1.64e-01	3.32e-01	0.15300	-1.10e-02	-0.152000	9.24e-01	1.87e-01
mRNA-decay-by-5’-to-3’-exoribonuclease	15	4.17e-01	5.87e-01	0.15300	1.29e-02	-0.152000	9.31e-01	3.07e-01
Toll-like-Receptor-Cascades	143	2.66e-02	1.01e-01	0.15200	7.89e-02	-0.130000	1.03e-01	7.37e-03
Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)	11	7.47e-01	8.45e-01	0.15200	-7.56e-02	0.132000	6.64e-01	4.50e-01
Semaphorin-interactions	63	4.24e-03	2.42e-02	0.15200	3.87e-02	0.147000	5.95e-01	4.39e-02
Regulation-of-cholesterol-biosynthesis-by-SREBP-(SREBF)	53	4.81e-02	1.49e-01	0.15200	1.29e-02	-0.151000	8.71e-01	5.69e-02
RHOB-GTPase-cycle	69	5.54e-04	4.66e-03	0.15200	1.01e-01	0.113000	1.46e-01	1.05e-01
Synthesis-of-Leukotrienes-(LT)-and-Eoxins-(EX)	15	2.04e-01	3.77e-01	0.15200	8.50e-02	0.125000	5.68e-01	4.00e-01
RHO-GTPases-activate-CIT	18	1.79e-01	3.50e-01	0.15100	1.40e-01	0.057500	3.04e-01	6.73e-01
FOXO-mediated-transcription-of-cell-death-genes	15	7.17e-01	8.24e-01	0.15100	-9.07e-02	0.121000	5.43e-01	4.17e-01
Diseases-associated-with-O-glycosylation-of-proteins	62	1.19e-03	8.66e-03	0.15100	1.08e-01	0.106000	1.40e-01	1.50e-01
Signaling-by-Insulin-receptor	71	2.06e-01	3.79e-01	0.15100	1.22e-01	-0.089800	7.63e-02	1.91e-01
HDMs-demethylate-histones	23	9.89e-02	2.37e-01	0.15100	-1.34e-01	-0.070000	2.66e-01	5.61e-01
Synthesis-of-PIPs-at-the-plasma-membrane	52	1.69e-02	7.25e-02	0.15100	2.46e-02	0.149000	7.59e-01	6.29e-02
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)	14	6.78e-01	8.00e-01	0.15100	1.33e-01	-0.071000	3.88e-01	6.45e-01
Striated-Muscle-Contraction	32	3.98e-01	5.70e-01	0.15100	1.35e-01	-0.068200	1.87e-01	5.04e-01
Potential-therapeutics-for-SARS	81	1.93e-01	3.67e-01	0.15100	-1.10e-01	0.103000	8.57e-02	1.10e-01
Activation-of-IRF3/IRF7-mediated-by-TBK1/IKK-epsilon	16	1.95e-01	3.69e-01	0.15000	-1.29e-01	-0.077200	3.72e-01	5.93e-01
Apoptotic-execution-phase	44	3.90e-02	1.32e-01	0.15000	1.49e-01	0.017700	8.69e-02	8.39e-01
trans-Golgi-Network-Vesicle-Budding	71	1.21e-01	2.71e-01	0.15000	6.45e-02	-0.136000	3.47e-01	4.82e-02
Sensory-processing-of-sound-by-inner-hair-cells-of-the-cochlea	63	5.94e-02	1.74e-01	0.15000	1.46e-01	-0.033000	4.44e-02	6.51e-01
Toll-Like-Receptor-9-(TLR9)-Cascade	89	1.57e-01	3.21e-01	0.15000	9.54e-02	-0.116000	1.19e-01	5.90e-02
Cell-extracellular-matrix-interactions	16	2.04e-01	3.77e-01	0.15000	-1.32e-01	-0.070300	3.59e-01	6.27e-01
mRNA-decay-by-3’-to-5’-exoribonuclease	15	6.79e-01	8.01e-01	0.15000	-7.50e-02	0.130000	6.15e-01	3.84e-01
Presynaptic-function-of-Kainate-receptors	20	4.39e-01	6.09e-01	0.14900	-3.90e-02	0.144000	7.63e-01	2.65e-01
Gap-junction-assembly	16	7.01e-01	8.13e-01	0.14900	-1.22e-01	0.085800	3.99e-01	5.52e-01
Signaling-by-BRAF-and-RAF1-fusions	62	2.94e-01	4.71e-01	0.14900	1.08e-01	-0.102000	1.40e-01	1.64e-01
G-protein-beta:gamma-signalling	30	4.00e-01	5.70e-01	0.14900	-6.07e-02	0.136000	5.65e-01	1.98e-01
SHC1-events-in-ERBB2-signaling	22	2.97e-01	4.74e-01	0.14800	1.22e-02	-0.148000	9.21e-01	2.30e-01
Signaling-by-FGFR1-in-disease	34	1.49e-01	3.10e-01	0.14800	1.02e-02	-0.148000	9.18e-01	1.36e-01
WNT5A-dependent-internalization-of-FZD4	15	3.77e-01	5.53e-01	0.14800	-1.48e-01	-0.005560	3.21e-01	9.70e-01
RAB-geranylgeranylation	63	2.93e-01	4.71e-01	0.14800	1.07e-01	-0.102000	1.42e-01	1.61e-01
Metabolism-of-porphyrins	26	5.42e-01	6.91e-01	0.14700	-7.79e-02	0.125000	4.91e-01	2.70e-01
Dectin-2-family	20	3.90e-01	5.65e-01	0.14700	1.45e-01	-0.025100	2.61e-01	8.46e-01
Apoptotic-cleavage-of-cellular-proteins	37	7.47e-02	1.98e-01	0.14700	1.46e-01	0.016500	1.24e-01	8.62e-01
RNA-Polymerase-III-Abortive-And-Retractive-Initiation	41	1.89e-01	3.60e-01	0.14700	3.67e-02	-0.142000	6.84e-01	1.15e-01
RNA-Polymerase-III-Transcription	41	1.89e-01	3.60e-01	0.14700	3.67e-02	-0.142000	6.84e-01	1.15e-01
G-alpha-(z)-signalling-events	46	3.59e-01	5.34e-01	0.14700	-8.14e-02	0.122000	3.39e-01	1.52e-01
FLT3-signaling-in-disease	27	1.11e-01	2.55e-01	0.14700	-3.82e-02	-0.142000	7.31e-01	2.03e-01
AURKA-Activation-by-TPX2	70	1.64e-01	3.32e-01	0.14600	1.29e-01	-0.069000	6.26e-02	3.18e-01
CDC42-GTPase-cycle	156	1.53e-03	1.05e-02	0.14600	-3.35e-02	0.142000	4.70e-01	2.17e-03
Interconversion-of-nucleotide-di–and-triphosphates	27	3.12e-01	4.91e-01	0.14600	3.06e-02	-0.143000	7.83e-01	2.00e-01
RHOBTB3-ATPase-cycle	10	7.53e-01	8.48e-01	0.14600	1.32e-01	-0.062100	4.70e-01	7.34e-01
B-WICH-complex-positively-regulates-rRNA-expression	29	5.33e-01	6.85e-01	0.14600	-1.20e-01	0.082200	2.62e-01	4.43e-01
Negative-regulators-of-DDX58/IFIH1-signaling	32	9.44e-02	2.29e-01	0.14500	-2.57e-02	-0.143000	8.02e-01	1.61e-01
Caspase-mediated-cleavage-of-cytoskeletal-proteins	12	3.54e-01	5.30e-01	0.14500	5.13e-02	0.136000	7.58e-01	4.15e-01
Tryptophan-catabolism	12	6.96e-01	8.10e-01	0.14500	-1.34e-01	0.056800	4.22e-01	7.33e-01
Transport-of-small-molecules	677	1.16e-06	3.51e-05	0.14500	1.17e-01	-0.085700	1.82e-07	1.35e-04
Presynaptic-phase-of-homologous-DNA-pairing-and-strand-exchange	39	7.23e-02	1.94e-01	0.14500	1.44e-01	0.015000	1.20e-01	8.71e-01
Downregulation-of-TGF-beta-receptor-signaling	25	6.09e-01	7.45e-01	0.14500	8.89e-02	-0.114000	4.41e-01	3.23e-01
Regulation-of-RUNX2-expression-and-activity	68	8.07e-03	3.97e-02	0.14500	-2.17e-02	-0.143000	7.57e-01	4.14e-02
Anti-inflammatory-response-favouring-Leishmania-parasite-infection	152	1.54e-02	6.81e-02	0.14500	-6.24e-02	0.130000	1.84e-01	5.46e-03
Leishmania-parasite-growth-and-survival	152	1.54e-02	6.81e-02	0.14500	-6.24e-02	0.130000	1.84e-01	5.46e-03
Transcriptional-regulation-by-RUNX2	114	5.09e-02	1.55e-01	0.14400	6.58e-02	-0.129000	2.25e-01	1.76e-02
Transcriptional-regulation-of-granulopoiesis	31	5.22e-01	6.78e-01	0.14400	-8.26e-02	0.118000	4.26e-01	2.54e-01
SMAD2/SMAD3:SMAD4-heterotrimer-regulates-transcription	31	7.05e-02	1.91e-01	0.14400	-1.35e-01	-0.051600	1.94e-01	6.19e-01
Formation-of-the-Early-Elongation-Complex	33	5.02e-02	1.54e-01	0.14400	6.41e-02	0.129000	5.24e-01	1.99e-01
Formation-of-the-HIV-1-Early-Elongation-Complex	33	5.02e-02	1.54e-01	0.14400	6.41e-02	0.129000	5.24e-01	1.99e-01
Caspase-activation-via-extrinsic-apoptotic-signalling-pathway	24	6.41e-01	7.74e-01	0.14400	-1.04e-01	0.100000	3.79e-01	3.95e-01
Signaling-by-CSF3-(G-CSF)	27	7.91e-02	2.02e-01	0.14400	-1.23e-01	-0.074500	2.67e-01	5.03e-01
Uptake-and-function-of-anthrax-toxins	11	8.03e-01	8.87e-01	0.14400	8.72e-02	-0.115000	6.16e-01	5.11e-01
Signaling-by-WNT-in-cancer	33	2.31e-01	4.08e-01	0.14400	1.41e-01	-0.025200	1.60e-01	8.02e-01
Signal-attenuation	10	7.19e-01	8.25e-01	0.14300	1.35e-01	-0.047900	4.59e-01	7.93e-01
Neurexins-and-neuroligins	52	6.53e-03	3.38e-02	0.14300	9.16e-02	0.110000	2.53e-01	1.69e-01
Assembly-and-cell-surface-presentation-of-NMDA-receptors	25	9.83e-02	2.36e-01	0.14300	1.22e-01	0.074600	2.91e-01	5.18e-01
Phenylalanine-and-tyrosine-metabolism	10	4.72e-01	6.40e-01	0.14300	-3.27e-02	-0.139000	8.58e-01	4.46e-01
Downstream-signaling-of-activated-FGFR1	26	3.00e-01	4.76e-01	0.14300	-1.41e-01	0.020400	2.12e-01	8.57e-01
Homologous-DNA-Pairing-and-Strand-Exchange	42	3.43e-02	1.23e-01	0.14300	1.36e-01	0.043800	1.28e-01	6.23e-01
Plasma-lipoprotein-clearance	33	3.97e-01	5.70e-01	0.14300	5.85e-02	-0.130000	5.61e-01	1.96e-01
RND3-GTPase-cycle	41	1.09e-01	2.52e-01	0.14200	1.42e-01	-0.005690	1.15e-01	9.50e-01
G1/S-Transition	127	5.15e-02	1.56e-01	0.14200	7.06e-02	-0.124000	1.69e-01	1.61e-02
Cell-Cycle,-Mitotic	479	9.44e-05	1.08e-03	0.14200	1.14e-01	-0.084900	1.78e-05	1.41e-03
Post-translational-modification:-synthesis-of-GPI-anchored-proteins	76	1.14e-01	2.59e-01	0.14200	1.31e-01	-0.056300	4.90e-02	3.96e-01
Initial-triggering-of-complement	28	5.24e-01	6.78e-01	0.14200	-1.23e-01	0.071300	2.60e-01	5.14e-01
GABA-synthesis,-release,-reuptake-and-degradation	17	7.06e-01	8.16e-01	0.14200	8.09e-02	-0.117000	5.63e-01	4.04e-01
DAG-and-IP3-signaling	39	4.24e-02	1.39e-01	0.14200	4.66e-02	0.134000	6.14e-01	1.47e-01
Xenobiotics	15	6.53e-01	7.82e-01	0.14100	-5.57e-02	0.130000	7.09e-01	3.83e-01
Attenuation-phase	22	3.75e-01	5.51e-01	0.14100	-1.40e-01	0.021800	2.57e-01	8.59e-01
Cell-junction-organization	78	2.17e-01	3.89e-01	0.14100	1.14e-01	-0.083000	8.08e-02	2.05e-01
Activation-of-the-AP-1-family-of-transcription-factors	10	7.68e-01	8.60e-01	0.14100	6.07e-02	-0.128000	7.40e-01	4.85e-01
Ca-dependent-events	35	1.46e-01	3.06e-01	0.14100	-2.04e-03	0.141000	9.83e-01	1.48e-01
RHOA-GTPase-cycle	144	7.26e-04	5.81e-03	0.14100	-9.92e-03	0.140000	8.37e-01	3.63e-03
Endogenous-sterols	25	5.87e-01	7.27e-01	0.14000	1.19e-01	-0.074800	3.04e-01	5.18e-01
Mitotic-G1-phase-and-G1/S-transition	144	5.38e-02	1.61e-01	0.14000	7.75e-02	-0.117000	1.08e-01	1.57e-02
Retrograde-transport-at-the-Trans-Golgi-Network	46	3.75e-01	5.51e-01	0.14000	1.19e-01	-0.073800	1.63e-01	3.86e-01
Olfactory-Signaling-Pathway	37	4.00e-01	5.71e-01	0.14000	1.25e-01	-0.063000	1.89e-01	5.07e-01
HDR-through-Homologous-Recombination-(HRR)	65	6.23e-02	1.77e-01	0.14000	1.38e-01	-0.023000	5.47e-02	7.49e-01
Base-Excision-Repair	45	4.34e-02	1.41e-01	0.14000	1.37e-01	0.028200	1.13e-01	7.44e-01
SLC-transporter-disorders	93	5.71e-03	3.08e-02	0.13900	1.39e-01	0.001500	2.00e-02	9.80e-01
Regulation-of-gene-expression-in-beta-cells	18	6.99e-01	8.12e-01	0.13900	-7.83e-02	0.115000	5.65e-01	3.98e-01
Spry-regulation-of-FGF-signaling	15	4.77e-01	6.45e-01	0.13900	1.39e-01	-0.009730	3.52e-01	9.48e-01
The-canonical-retinoid-cycle-in-rods-(twilight-vision)	19	5.05e-01	6.64e-01	0.13800	3.48e-02	-0.134000	7.93e-01	3.13e-01
Inositol-phosphate-metabolism	46	1.62e-02	7.07e-02	0.13800	8.52e-02	0.109000	3.17e-01	2.02e-01
NOD1/2-Signaling-Pathway	30	6.81e-02	1.88e-01	0.13800	-8.70e-02	-0.107000	4.09e-01	3.11e-01
PLC-beta-mediated-events	47	6.19e-02	1.76e-01	0.13700	1.12e-02	0.137000	8.94e-01	1.04e-01
Chaperone-Mediated-Autophagy	19	2.45e-01	4.21e-01	0.13700	-4.10e-02	-0.131000	7.57e-01	3.22e-01
Signaling-by-FGFR2-IIIa-TM	19	6.03e-01	7.40e-01	0.13700	1.26e-01	-0.054700	3.41e-01	6.80e-01
Phospholipid-metabolism	195	9.06e-03	4.39e-02	0.13700	1.23e-01	-0.060900	3.00e-03	1.42e-01
Diseases-of-glycosylation	130	2.88e-04	2.79e-03	0.13700	1.86e-02	0.136000	7.15e-01	7.33e-03
Cargo-concentration-in-the-ER	33	6.07e-02	1.74e-01	0.13700	-1.18e-01	-0.070300	2.42e-01	4.85e-01
Fatty-acid-metabolism	155	4.94e-04	4.26e-03	0.13700	6.68e-03	-0.137000	8.86e-01	3.27e-03
CaMK-IV-mediated-phosphorylation-of-CREB	10	7.71e-01	8.61e-01	0.13700	-5.57e-02	0.125000	7.61e-01	4.93e-01
TRAF6-mediated-IRF7-activation	15	3.98e-01	5.70e-01	0.13700	-1.67e-02	-0.136000	9.11e-01	3.63e-01
Synthesis-of-IP3-and-IP4-in-the-cytosol	25	2.99e-01	4.76e-01	0.13700	-8.51e-03	0.136000	9.41e-01	2.37e-01
RUNX2-regulates-bone-development	31	5.91e-01	7.31e-01	0.13700	1.03e-01	-0.089500	3.20e-01	3.88e-01
O-linked-glycosylation	98	5.58e-03	3.03e-02	0.13600	1.04e-03	0.136000	9.86e-01	1.95e-02
FGFR4-ligand-binding-and-activation	11	3.80e-01	5.56e-01	0.13600	-1.02e-01	-0.090500	5.59e-01	6.03e-01
YAP1–and-WWTR1-(TAZ)-stimulated-gene-expression	12	5.06e-01	6.64e-01	0.13600	-1.36e-01	-0.008520	4.15e-01	9.59e-01
G-beta:gamma-signalling-through-PLC-beta	19	4.68e-01	6.38e-01	0.13600	-2.39e-02	0.134000	8.57e-01	3.11e-01
PI-3K-cascade:FGFR1	16	5.32e-01	6.84e-01	0.13600	-1.34e-01	0.024600	3.54e-01	8.64e-01
PECAM1-interactions	12	6.44e-01	7.76e-01	0.13500	-2.95e-02	0.132000	8.60e-01	4.28e-01
FGFR2c-ligand-binding-and-activation	10	8.37e-01	9.06e-01	0.13500	8.07e-02	-0.108000	6.59e-01	5.52e-01
Sensory-processing-of-sound-by-outer-hair-cells-of-the-cochlea	48	2.09e-01	3.82e-01	0.13500	1.30e-01	-0.037600	1.20e-01	6.52e-01
Glycogen-metabolism	25	5.64e-01	7.07e-01	0.13500	1.20e-01	-0.061100	2.98e-01	5.97e-01
AKT-phosphorylates-targets-in-the-cytosol	14	5.44e-01	6.91e-01	0.13500	-1.50e-02	0.134000	9.23e-01	3.85e-01
Cardiac-conduction	112	1.17e-03	8.55e-03	0.13500	1.34e-01	0.018000	1.46e-02	7.42e-01
Glycogen-breakdown-(glycogenolysis)	14	5.42e-01	6.91e-01	0.13400	1.34e-01	-0.014000	3.86e-01	9.28e-01
Transcription-Coupled-Nucleotide-Excision-Repair-(TC-NER)	77	3.37e-02	1.22e-01	0.13400	1.33e-01	-0.012000	4.36e-02	8.56e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-Cytochrome-C-Release	18	5.22e-01	6.78e-01	0.13300	1.31e-01	-0.028000	3.38e-01	8.37e-01
Toll-Like-Receptor-3-(TLR3)-Cascade	88	1.50e-01	3.12e-01	0.13300	6.28e-02	-0.118000	3.08e-01	5.65e-02
TGF-beta-receptor-signaling-activates-SMADs	31	5.65e-01	7.07e-01	0.13300	7.38e-02	-0.111000	4.77e-01	2.85e-01
Post-translational-protein-phosphorylation	99	2.04e-01	3.77e-01	0.13300	1.00e-01	-0.087800	8.48e-02	1.31e-01
Removal-of-the-Flap-Intermediate	14	5.80e-01	7.23e-01	0.13300	-2.21e-02	0.131000	8.86e-01	3.95e-01
TNF-signaling	42	3.97e-01	5.70e-01	0.13300	6.13e-02	-0.118000	4.91e-01	1.85e-01
PI-3K-cascade:FGFR4	17	2.42e-01	4.19e-01	0.13300	-8.49e-02	-0.102000	5.44e-01	4.65e-01
PI3K/AKT-Signaling-in-Cancer	98	1.87e-01	3.60e-01	0.13300	-1.07e-01	0.079100	6.81e-02	1.76e-01
Metabolism-of-nitric-oxide:-NOS3-activation-and-regulation	15	4.07e-01	5.78e-01	0.13300	-1.31e-01	-0.020400	3.80e-01	8.91e-01
Regulation-of-PLK1-Activity-at-G2/M-Transition	84	2.71e-01	4.51e-01	0.13200	9.22e-02	-0.094700	1.44e-01	1.33e-01
Golgi-to-ER-retrograde-transport	109	4.02e-02	1.34e-01	0.13200	1.25e-01	-0.039800	2.35e-02	4.72e-01
Inactivation,-recovery-and-regulation-of-the-phototransduction-cascade	30	4.62e-01	6.31e-01	0.13200	4.89e-02	-0.122000	6.43e-01	2.47e-01
The-phototransduction-cascade	30	4.62e-01	6.31e-01	0.13200	4.89e-02	-0.122000	6.43e-01	2.47e-01
Hyaluronan-metabolism	16	2.76e-01	4.55e-01	0.13100	7.68e-02	0.107000	5.95e-01	4.60e-01
Glucagon-type-ligand-receptors	28	1.01e-01	2.41e-01	0.13100	9.21e-02	0.093600	3.99e-01	3.91e-01
Metabolism	1892	1.65e-12	6.98e-11	0.13100	9.09e-02	-0.094600	3.66e-11	5.66e-12
Telomere-C-strand-(Lagging-Strand)-Synthesis	34	9.70e-02	2.34e-01	0.13100	4.25e-02	0.124000	6.68e-01	2.12e-01
Inhibition-of-replication-initiation-of-damaged-DNA-by-RB1/E2F1	13	7.54e-01	8.48e-01	0.13100	1.17e-01	-0.058800	4.66e-01	7.14e-01
Other-interleukin-signaling	22	7.05e-01	8.15e-01	0.13100	-8.22e-02	0.101000	5.05e-01	4.10e-01
Hedgehog-‘on’-state	83	1.74e-03	1.16e-02	0.13100	-6.60e-02	-0.113000	2.98e-01	7.60e-02
Acetylcholine-binding-and-downstream-events	10	6.49e-01	7.80e-01	0.13000	-9.54e-03	0.130000	9.58e-01	4.76e-01
Postsynaptic-nicotinic-acetylcholine-receptors	10	6.49e-01	7.80e-01	0.13000	-9.54e-03	0.130000	9.58e-01	4.76e-01
Transcriptional-Regulation-by-E2F6	33	5.41e-01	6.91e-01	0.13000	6.82e-02	-0.111000	4.98e-01	2.70e-01
Pre-NOTCH-Expression-and-Processing	50	2.15e-01	3.88e-01	0.13000	-3.53e-02	0.125000	6.66e-01	1.25e-01
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)	111	1.89e-01	3.60e-01	0.13000	9.17e-02	-0.092100	9.48e-02	9.34e-02
ATF4-activates-genes-in-response-to-endoplasmic-reticulum–stress	24	3.27e-01	5.04e-01	0.13000	1.67e-03	-0.130000	9.89e-01	2.71e-01
MyD88-independent-TLR4-cascade	92	1.18e-01	2.66e-01	0.13000	5.28e-02	-0.118000	3.81e-01	4.95e-02
TRIF(TICAM1)-mediated-TLR4-signaling	92	1.18e-01	2.66e-01	0.13000	5.28e-02	-0.118000	3.81e-01	4.95e-02
Acyl-chain-remodelling-of-PI	13	7.83e-01	8.72e-01	0.12900	6.57e-02	-0.111000	6.82e-01	4.87e-01
Tie2-Signaling	18	6.00e-01	7.38e-01	0.12900	-3.89e-02	0.123000	7.75e-01	3.67e-01
Interleukin-12-signaling	44	4.17e-02	1.38e-01	0.12900	-5.74e-02	-0.115000	5.10e-01	1.86e-01
Energy-dependent-regulation-of-mTOR-by-LKB1-AMPK	29	1.47e-01	3.08e-01	0.12900	1.22e-01	0.041200	2.56e-01	7.01e-01
Phase-4—resting-membrane-potential	15	8.01e-01	8.87e-01	0.12800	-8.61e-02	0.095100	5.63e-01	5.24e-01
Metabolism-of-RNA	646	3.60e-08	1.30e-06	0.12800	4.09e-02	-0.121000	7.52e-02	1.26e-07
NCAM-signaling-for-neurite-out-growth	57	1.37e-02	6.25e-02	0.12800	7.16e-02	0.106000	3.50e-01	1.66e-01
Association-of-TriC/CCT-with-target-proteins-during-biosynthesis	37	6.66e-02	1.85e-01	0.12800	-1.11e-01	-0.063800	2.44e-01	5.01e-01
Thrombin-signalling-through-proteinase-activated-receptors-(PARs)	31	3.95e-01	5.69e-01	0.12700	-3.29e-02	0.123000	7.51e-01	2.37e-01
Diseases-of-DNA-repair	33	1.02e-01	2.43e-01	0.12700	1.15e-01	0.053200	2.52e-01	5.97e-01
RHO-GTPases-activate-PAKs	21	4.72e-01	6.40e-01	0.12700	1.25e-01	-0.019400	3.21e-01	8.78e-01
Signaling-by-cytosolic-FGFR1-fusion-mutants	17	2.83e-01	4.59e-01	0.12600	-7.86e-02	-0.097900	5.75e-01	4.84e-01
Nuclear-Pore-Complex-(NPC)-Disassembly	34	2.74e-01	4.53e-01	0.12500	1.25e-01	-0.012900	2.08e-01	8.97e-01
Signaling-by-NOTCH4	79	2.66e-02	1.01e-01	0.12500	-3.56e-03	-0.125000	9.56e-01	5.41e-02
VEGFA-VEGFR2-Pathway	92	2.75e-01	4.53e-01	0.12500	-9.28e-02	0.084000	1.24e-01	1.63e-01
Competing-endogenous-RNAs-(ceRNAs)-regulate-PTEN-translation	10	8.70e-01	9.30e-01	0.12500	-8.80e-02	0.088800	6.30e-01	6.27e-01
NS1-Mediated-Effects-on-Host-Pathways	36	3.96e-01	5.70e-01	0.12500	1.18e-01	-0.040100	2.19e-01	6.77e-01
Fc-epsilon-receptor-(FCERI)-signaling	138	3.08e-03	1.88e-02	0.12500	4.13e-03	-0.125000	9.33e-01	1.12e-02
Synthesis-of-PIPs-at-the-Golgi-membrane	17	4.69e-01	6.38e-01	0.12500	1.23e-03	0.125000	9.93e-01	3.73e-01
Sialic-acid-metabolism	30	2.66e-01	4.44e-01	0.12400	1.30e-03	0.124000	9.90e-01	2.39e-01
Biosynthesis-of-DHA-derived-SPMs	15	3.37e-01	5.13e-01	0.12400	7.76e-02	0.097000	6.03e-01	5.15e-01
MET-activates-RAS-signaling	11	8.58e-01	9.24e-01	0.12400	9.28e-02	-0.082100	5.94e-01	6.37e-01
SUMOylation	166	9.21e-02	2.25e-01	0.12400	-9.72e-02	0.076400	3.05e-02	8.92e-02
Neuronal-System	352	6.85e-09	2.67e-07	0.12400	1.21e-01	0.023300	8.82e-05	4.52e-01
Voltage-gated-Potassium-channels	38	4.13e-01	5.82e-01	0.12400	1.15e-01	-0.044300	2.19e-01	6.36e-01
Deadenylation-dependent-mRNA-decay	54	7.82e-02	2.01e-01	0.12400	-1.23e-01	-0.008850	1.17e-01	9.10e-01
Cell-Cycle	603	1.23e-04	1.34e-03	0.12300	1.01e-01	-0.071000	2.22e-05	2.83e-03
RUNX1-regulates-genes-involved-in-megakaryocyte-differentiation-and-platelet-function	37	5.18e-01	6.75e-01	0.12300	-1.07e-01	0.060200	2.58e-01	5.26e-01
Carnitine-metabolism	12	4.29e-01	5.98e-01	0.12200	-7.63e-02	-0.095800	6.47e-01	5.65e-01
NR1H2-and-NR1H3-mediated-signaling	44	5.52e-01	6.96e-01	0.12200	9.11e-02	-0.081800	2.96e-01	3.47e-01
Metabolism-of-non-coding-RNA	50	5.06e-01	6.64e-01	0.12200	-7.81e-02	0.093400	3.39e-01	2.53e-01
snRNP-Assembly	50	5.06e-01	6.64e-01	0.12200	-7.81e-02	0.093400	3.39e-01	2.53e-01
Nephrin-family-interactions	22	4.60e-01	6.30e-01	0.12200	1.21e-01	-0.013700	3.26e-01	9.11e-01
Regulation-of-TNFR1-signaling	33	3.00e-01	4.76e-01	0.12100	1.06e-02	-0.121000	9.16e-01	2.30e-01
Activation-of-ATR-in-response-to-replication-stress	37	1.28e-01	2.80e-01	0.12100	1.17e-01	0.031900	2.19e-01	7.37e-01
Response-of-Mtb-to-phagocytosis	21	6.46e-01	7.77e-01	0.12100	4.76e-02	-0.111000	7.06e-01	3.78e-01
Polymerase-switching-on-the-C-strand-of-the-telomere	26	2.60e-01	4.38e-01	0.12100	2.34e-02	0.118000	8.37e-01	2.96e-01
Chromatin-modifying-enzymes	198	7.55e-02	1.98e-01	0.12000	-9.06e-02	0.079200	2.78e-02	5.45e-02
Chromatin-organization	198	7.55e-02	1.98e-01	0.12000	-9.06e-02	0.079200	2.78e-02	5.45e-02
Signaling-by-Receptor-Tyrosine-Kinases	482	7.02e-04	5.65e-03	0.12000	-6.50e-02	0.101000	1.43e-02	1.42e-04
Carboxyterminal-post-translational-modifications-of-tubulin	34	1.62e-01	3.29e-01	0.12000	1.16e-01	0.028900	2.40e-01	7.71e-01
Downstream-TCR-signaling	89	3.37e-03	2.02e-02	0.11900	-6.02e-02	-0.103000	3.26e-01	9.28e-02
Centrosome-maturation	77	2.59e-01	4.36e-01	0.11900	1.06e-01	-0.054700	1.09e-01	4.06e-01
Recruitment-of-mitotic-centrosome-proteins-and-complexes	77	2.59e-01	4.36e-01	0.11900	1.06e-01	-0.054700	1.09e-01	4.06e-01
Nucleotide-binding-domain,-leucine-rich-repeat-containing-receptor-(NLR)-signaling-pathways	50	3.31e-01	5.08e-01	0.11900	-1.11e-01	0.040800	1.73e-01	6.18e-01
ALK-mutants-bind-TKIs	11	5.49e-01	6.93e-01	0.11800	3.50e-02	0.113000	8.40e-01	5.17e-01
Nicotinate-metabolism	29	3.10e-01	4.89e-01	0.11800	-2.32e-03	-0.118000	9.83e-01	2.71e-01
CTLA4-inhibitory-signaling	21	2.96e-01	4.74e-01	0.11800	1.09e-01	0.044600	3.86e-01	7.24e-01
Transport-of-Ribonucleoproteins-into-the-Host-Nucleus	30	2.83e-01	4.59e-01	0.11800	1.18e-01	0.006300	2.64e-01	9.52e-01
CD209-(DC-SIGN)-signaling	19	7.90e-01	8.78e-01	0.11800	-8.12e-02	0.085400	5.40e-01	5.19e-01
Interferon-gamma-signaling	70	2.58e-01	4.36e-01	0.11800	-4.76e-02	0.108000	4.91e-01	1.19e-01
Signaling-by-ERBB2	47	9.48e-02	2.30e-01	0.11700	-2.54e-02	-0.115000	7.63e-01	1.74e-01
Sphingolipid-de-novo-biosynthesis	42	6.41e-02	1.80e-01	0.11700	-8.18e-02	-0.084200	3.59e-01	3.45e-01
Defective-HDR-through-Homologous-Recombination-(HRR)-due-to-PALB2-loss-of-function	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Defective-HDR-through-Homologous-Recombination-Repair-(HRR)-due-to-PALB2-loss-of-BRCA1-binding-function	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Defective-HDR-through-Homologous-Recombination-Repair-(HRR)-due-to-PALB2-loss-of-BRCA2/RAD51/RAD51C-binding-function	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Diseases-of-DNA-Double-Strand-Break-Repair	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Antimicrobial-peptides	35	2.58e-01	4.36e-01	0.11700	1.17e-01	0.000302	2.31e-01	9.98e-01
Downstream-signaling-of-activated-FGFR4	24	2.67e-01	4.45e-01	0.11700	-3.87e-02	-0.110000	7.43e-01	3.49e-01
TCR-signaling	111	6.40e-03	3.34e-02	0.11700	-1.16e-01	-0.016000	3.50e-02	7.71e-01
Interferon-alpha/beta-signaling	44	5.83e-01	7.25e-01	0.11700	-7.76e-02	0.087100	3.73e-01	3.18e-01
Chromosome-Maintenance	88	1.36e-01	2.94e-01	0.11600	1.11e-01	-0.036300	7.27e-02	5.56e-01
Signaling-by-PDGFR-in-disease	19	6.94e-01	8.09e-01	0.11600	-1.07e-01	0.045900	4.20e-01	7.29e-01
Signaling-by-FGFR2	66	2.93e-01	4.71e-01	0.11600	4.71e-02	-0.106000	5.08e-01	1.37e-01
Loss-of-Nlp-from-mitotic-centrosomes	67	3.71e-01	5.47e-01	0.11500	9.87e-02	-0.059000	1.62e-01	4.04e-01
Loss-of-proteins-required-for-interphase-microtubule-organization-from-the-centrosome	67	3.71e-01	5.47e-01	0.11500	9.87e-02	-0.059000	1.62e-01	4.04e-01
Regulation-of-TP53-Activity-through-Phosphorylation	88	1.84e-01	3.59e-01	0.11500	1.06e-01	-0.043700	8.51e-02	4.78e-01
Thromboxane-signalling-through-TP-receptor	23	3.48e-01	5.23e-01	0.11400	2.11e-02	0.112000	8.61e-01	3.51e-01
Transcriptional-regulation-by-small-RNAs	46	2.68e-01	4.46e-01	0.11400	1.13e-01	-0.018500	1.86e-01	8.28e-01
Synthesis-of-glycosylphosphatidylinositol-(GPI)	18	3.37e-01	5.13e-01	0.11400	-6.59e-02	-0.093200	6.28e-01	4.94e-01
Gastrin-CREB-signalling-pathway-via-PKC-and-MAPK	17	5.87e-01	7.27e-01	0.11400	1.13e-01	-0.012300	4.18e-01	9.30e-01
Signaling-by-TGFB-family-members	98	3.73e-02	1.28e-01	0.11400	6.26e-03	-0.113000	9.15e-01	5.22e-02
CASP8-activity-is-inhibited	10	8.22e-01	9.01e-01	0.11400	-1.06e-01	0.041200	5.62e-01	8.22e-01
Dimerization-of-procaspase-8	10	8.22e-01	9.01e-01	0.11400	-1.06e-01	0.041200	5.62e-01	8.22e-01
Regulation-by-c-FLIP	10	8.22e-01	9.01e-01	0.11400	-1.06e-01	0.041200	5.62e-01	8.22e-01
VLDLR-internalisation-and-degradation	12	4.86e-01	6.49e-01	0.11300	9.06e-02	0.068200	5.87e-01	6.83e-01
Developmental-Biology	833	2.36e-05	3.75e-04	0.11300	9.37e-02	-0.063100	3.91e-06	1.87e-03
Depolymerisation-of-the-Nuclear-Lamina	15	6.94e-01	8.09e-01	0.11300	1.10e-01	-0.027600	4.62e-01	8.53e-01
Protein-ubiquitination	60	5.28e-02	1.59e-01	0.11300	-1.09e-01	-0.031200	1.46e-01	6.75e-01
Cell-surface-interactions-at-the-vascular-wall	126	3.05e-02	1.12e-01	0.11200	-1.84e-02	0.111000	7.22e-01	3.14e-02
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain	13	8.64e-01	9.27e-01	0.11200	7.68e-02	-0.081700	6.32e-01	6.10e-01
Hedgehog-‘off’-state	96	9.42e-03	4.52e-02	0.11200	-1.07e-01	-0.032200	6.91e-02	5.86e-01
Interleukin-4-and-Interleukin-13-signaling	101	2.97e-01	4.74e-01	0.11200	-6.78e-02	0.089100	2.39e-01	1.21e-01
Interleukin-17-signaling	68	4.69e-01	6.38e-01	0.11200	8.07e-02	-0.077400	2.50e-01	2.69e-01
Transcriptional-regulation-by-RUNX3	93	1.55e-02	6.83e-02	0.11200	-2.28e-02	-0.109000	7.04e-01	6.80e-02
G-protein-activation	21	3.67e-01	5.43e-01	0.11200	3.05e-02	0.107000	8.09e-01	3.94e-01
COPI-mediated-anterograde-transport	80	4.18e-02	1.38e-01	0.11200	1.11e-01	0.010800	8.57e-02	8.67e-01
Beta-defensins	17	6.74e-01	7.98e-01	0.11200	1.08e-01	-0.028600	4.42e-01	8.38e-01
Organelle-biogenesis-and-maintenance	247	3.38e-02	1.22e-01	0.11100	-5.76e-02	0.095400	1.19e-01	9.69e-03
Processive-synthesis-on-the-lagging-strand	15	4.78e-01	6.45e-01	0.11100	3.55e-02	0.105000	8.12e-01	4.81e-01
Degradation-of-the-extracellular-matrix	99	8.49e-02	2.13e-01	0.11100	-2.31e-02	0.108000	6.91e-01	6.21e-02
Transcriptional-Regulation-by-TP53	338	4.79e-03	2.69e-02	0.11100	9.96e-02	-0.048400	1.61e-03	1.25e-01
Aggrephagy	21	4.08e-01	5.78e-01	0.11100	-1.95e-02	-0.109000	8.77e-01	3.87e-01
RHOJ-GTPase-cycle	55	5.08e-01	6.65e-01	0.11100	-6.34e-02	0.090700	4.16e-01	2.45e-01
Acyl-chain-remodelling-of-PG	16	6.56e-01	7.85e-01	0.11000	1.08e-01	-0.018600	4.53e-01	8.97e-01
Programmed-Cell-Death	185	1.24e-01	2.74e-01	0.11000	6.83e-02	-0.086100	1.09e-01	4.31e-02
Neddylation	224	1.16e-02	5.42e-02	0.11000	3.46e-02	-0.104000	3.71e-01	7.19e-03
RAC1-GTPase-cycle	180	6.45e-02	1.81e-01	0.11000	-4.92e-02	0.098000	2.55e-01	2.31e-02
CD28-co-stimulation	33	6.99e-01	8.12e-01	0.11000	-7.28e-02	0.081900	4.69e-01	4.15e-01
Transmission-across-Chemical-Synapses	227	3.10e-04	2.96e-03	0.11000	1.09e-01	0.004750	4.45e-03	9.02e-01
Post-chaperonin-tubulin-folding-pathway	17	4.84e-01	6.48e-01	0.10900	1.07e-01	0.022200	4.46e-01	8.74e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE	27	3.27e-01	5.04e-01	0.10900	1.07e-01	0.019200	3.34e-01	8.63e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE-during-HIV-infection	27	3.27e-01	5.04e-01	0.10900	1.07e-01	0.019200	3.34e-01	8.63e-01
SARS-CoV-Infections	147	2.14e-01	3.88e-01	0.10900	-7.56e-02	0.078200	1.13e-01	1.01e-01
Hyaluronan-uptake-and-degradation	12	6.15e-01	7.48e-01	0.10900	1.75e-02	0.107000	9.17e-01	5.20e-01
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic	173	6.88e-02	1.88e-01	0.10900	9.80e-02	-0.047000	2.60e-02	2.86e-01
MAP-kinase-activation	61	4.85e-01	6.49e-01	0.10800	6.20e-02	-0.089000	4.02e-01	2.29e-01
SUMO-E3-ligases-SUMOylate-target-proteins	160	1.65e-01	3.33e-01	0.10800	-8.65e-02	0.065000	5.87e-02	1.56e-01
CREB1-phosphorylation-through-the-activation-of-Adenylate-Cyclase	11	8.76e-01	9.33e-01	0.10800	-5.96e-02	0.089600	7.32e-01	6.07e-01
G-beta:gamma-signalling-through-BTK	17	3.93e-01	5.67e-01	0.10800	7.87e-02	0.073400	5.74e-01	6.00e-01
Muscle-contraction	174	4.08e-04	3.64e-03	0.10700	1.02e-01	0.031900	1.96e-02	4.68e-01
Vpr-mediated-nuclear-import-of-PICs	32	4.21e-01	5.90e-01	0.10700	1.06e-01	-0.013000	2.98e-01	8.99e-01
TRAF3-dependent-IRF-activation-pathway	13	5.76e-01	7.19e-01	0.10700	-1.04e-01	-0.025100	5.16e-01	8.75e-01
Translesion-synthesis-by-Y-family-DNA-polymerases-bypasses-lesions-on-DNA-template	37	6.10e-01	7.46e-01	0.10600	9.30e-02	-0.051700	3.28e-01	5.86e-01
Common-Pathway-of-Fibrin-Clot-Formation	20	8.15e-01	8.96e-01	0.10600	7.93e-02	-0.070900	5.39e-01	5.83e-01
Removal-of-the-Flap-Intermediate-from-the-C-strand	17	6.91e-01	8.09e-01	0.10600	-2.55e-02	0.103000	8.56e-01	4.61e-01
Selective-autophagy	59	5.31e-01	6.84e-01	0.10600	6.48e-02	-0.084000	3.89e-01	2.64e-01
Caspase-activation-via-Death-Receptors-in-the-presence-of-ligand	15	5.07e-01	6.64e-01	0.10500	-9.78e-02	-0.037900	5.12e-01	8.00e-01
Resolution-of-D-Loop-Structures	33	2.06e-01	3.79e-01	0.10500	9.38e-02	0.046800	3.51e-01	6.42e-01
Regulation-of-IFNG-signaling	13	8.03e-01	8.87e-01	0.10500	3.71e-02	-0.097900	8.17e-01	5.41e-01
Methylation	14	5.37e-01	6.89e-01	0.10500	-9.83e-02	-0.035700	5.24e-01	8.17e-01
NOTCH2-Activation-and-Transmission-of-Signal-to-the-Nucleus	21	7.53e-01	8.48e-01	0.10400	-9.27e-02	0.048000	4.62e-01	7.03e-01
NGF-stimulated-transcription	39	4.10e-01	5.80e-01	0.10400	-1.02e-01	0.019500	2.69e-01	8.33e-01
HCMV-Early-Events	57	3.87e-01	5.62e-01	0.10400	-3.69e-02	0.097200	6.30e-01	2.04e-01
Metabolism-of-amine-derived-hormones	16	7.46e-01	8.44e-01	0.10400	3.14e-02	-0.098800	8.28e-01	4.94e-01
G-alpha-(12/13)-signalling-events	77	4.08e-02	1.36e-01	0.10400	2.97e-02	0.099200	6.52e-01	1.32e-01
HSF1-activation	25	3.86e-01	5.61e-01	0.10400	-1.02e-01	-0.020100	3.79e-01	8.62e-01
Platelet-sensitization-by-LDL	17	7.33e-01	8.35e-01	0.10400	9.86e-02	-0.031400	4.81e-01	8.22e-01
Membrane-Trafficking	578	2.43e-03	1.54e-02	0.10300	8.41e-02	-0.060200	5.27e-04	1.30e-02
Reversible-hydration-of-carbon-dioxide	12	7.88e-01	8.76e-01	0.10300	9.99e-02	-0.026700	5.49e-01	8.73e-01
PI-Metabolism	82	2.61e-02	1.01e-01	0.10300	3.88e-02	0.095900	5.43e-01	1.33e-01
AKT-phosphorylates-targets-in-the-nucleus	10	8.71e-01	9.30e-01	0.10300	4.55e-02	-0.092900	8.03e-01	6.11e-01
Syndecan-interactions	20	4.28e-01	5.98e-01	0.10300	3.38e-02	0.097000	7.94e-01	4.53e-01
rRNA-modification-in-the-nucleus-and-cytosol	58	5.98e-02	1.74e-01	0.10300	-8.49e-02	-0.057600	2.63e-01	4.47e-01
Signaling-by-the-B-Cell-Receptor-(BCR)	120	2.66e-03	1.67e-02	0.10200	-6.58e-02	-0.078500	2.13e-01	1.37e-01
Ion-homeostasis	49	1.52e-01	3.14e-01	0.10200	9.97e-02	0.023200	2.27e-01	7.79e-01
Cleavage-of-the-damaged-pyrimidine	16	6.93e-01	8.09e-01	0.10200	1.01e-01	-0.016700	4.86e-01	9.08e-01
Depyrimidination	16	6.93e-01	8.09e-01	0.10200	1.01e-01	-0.016700	4.86e-01	9.08e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-pyrimidine	16	6.93e-01	8.09e-01	0.10200	1.01e-01	-0.016700	4.86e-01	9.08e-01
Aquaporin-mediated-transport	47	2.97e-01	4.74e-01	0.10200	1.02e-01	-0.008850	2.28e-01	9.16e-01
ADP-signalling-through-P2Y-purinoceptor-12	20	6.43e-01	7.75e-01	0.10200	1.00e-01	-0.018500	4.38e-01	8.86e-01
Signaling-by-FGFR4	37	4.92e-01	6.55e-01	0.10200	2.63e-02	-0.098200	7.82e-01	3.01e-01
Interleukin-37-signaling	20	3.86e-01	5.62e-01	0.10200	-5.72e-02	-0.083800	6.58e-01	5.16e-01
Metabolism-of-nucleotides	93	4.22e-01	5.90e-01	0.10100	7.64e-02	-0.066200	2.03e-01	2.69e-01
Glutathione-conjugation	29	7.55e-01	8.48e-01	0.10100	6.16e-02	-0.079800	5.66e-01	4.57e-01
Interactions-of-Rev-with-host-cellular-proteins	34	2.30e-01	4.06e-01	0.10100	4.13e-02	0.091900	6.77e-01	3.54e-01
Dual-incision-in-TC-NER	64	1.12e-01	2.55e-01	0.10100	9.95e-02	0.014900	1.68e-01	8.37e-01
ZBP1(DAI)-mediated-induction-of-type-I-IFNs	20	7.01e-01	8.13e-01	0.10100	9.63e-02	-0.029000	4.56e-01	8.22e-01
Phospholipase-C-mediated-cascade;-FGFR3	11	8.02e-01	8.87e-01	0.10100	2.24e-02	-0.098000	8.98e-01	5.74e-01
Diseases-of-carbohydrate-metabolism	30	5.01e-01	6.62e-01	0.10000	-9.92e-02	0.013600	3.47e-01	8.98e-01
Signalling-to-ERKs	33	6.62e-01	7.88e-01	0.09970	-4.52e-02	0.088800	6.53e-01	3.77e-01
Interleukin-12-family-signaling	54	8.38e-02	2.11e-01	0.09950	-8.12e-02	-0.057500	3.02e-01	4.65e-01
Ca2+-pathway	60	3.99e-01	5.70e-01	0.09940	-3.48e-02	0.093100	6.41e-01	2.12e-01
Formation-of-HIV-elongation-complex-in-the-absence-of-HIV-Tat	41	2.21e-01	3.95e-01	0.09910	9.60e-02	0.024500	2.87e-01	7.86e-01
Metabolism-of-carbohydrates	266	4.82e-06	1.23e-04	0.09890	6.86e-02	0.071200	5.37e-02	4.54e-02
Formation-of-HIV-1-elongation-complex-containing-HIV-1-Tat	39	1.75e-01	3.45e-01	0.09860	8.24e-02	0.054200	3.73e-01	5.58e-01
HIV-Transcription-Elongation	39	1.75e-01	3.45e-01	0.09860	8.24e-02	0.054200	3.73e-01	5.58e-01
Tat-mediated-elongation-of-the-HIV-1-transcript	39	1.75e-01	3.45e-01	0.09860	8.24e-02	0.054200	3.73e-01	5.58e-01
Cyclin-D-associated-events-in-G1	45	5.67e-01	7.09e-01	0.09850	8.86e-02	-0.043100	3.04e-01	6.16e-01
G1-Phase	45	5.67e-01	7.09e-01	0.09850	8.86e-02	-0.043100	3.04e-01	6.16e-01
Class-C/3-(Metabotropic-glutamate/pheromone-receptors)	21	5.21e-01	6.78e-01	0.09850	9.75e-03	0.098000	9.38e-01	4.37e-01
CD28-dependent-PI3K/Akt-signaling	22	7.93e-01	8.80e-01	0.09830	-5.20e-02	0.083500	6.73e-01	4.98e-01
Sensory-Perception	189	1.64e-01	3.32e-01	0.09820	8.01e-02	-0.056800	5.74e-02	1.77e-01
TFAP2-(AP-2)-family-regulates-transcription-of-growth-factors-and-their-receptors	11	9.09e-01	9.50e-01	0.09790	-6.46e-02	0.073600	7.10e-01	6.73e-01
RHOH-GTPase-cycle	37	6.24e-01	7.57e-01	0.09770	-4.15e-02	0.088400	6.62e-01	3.52e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-TC-NER	63	7.76e-02	2.00e-01	0.09760	8.90e-02	0.040100	2.22e-01	5.82e-01
NOTCH1-Intracellular-Domain-Regulates-Transcription	46	6.03e-01	7.40e-01	0.09740	-4.82e-02	0.084600	5.72e-01	3.21e-01
Mitotic-Prophase	81	3.13e-01	4.91e-01	0.09730	9.07e-02	-0.035200	1.58e-01	5.84e-01
Cell-cell-junction-organization	53	2.74e-01	4.53e-01	0.09720	9.70e-02	-0.005760	2.22e-01	9.42e-01
PPARA-activates-gene-expression	114	6.42e-03	3.34e-02	0.09710	-7.48e-02	-0.061900	1.68e-01	2.53e-01
Recruitment-of-NuMA-to-mitotic-centrosomes	77	3.36e-01	5.13e-01	0.09690	9.03e-02	-0.035400	1.71e-01	5.92e-01
Base-Excision-Repair,-AP-Site-Formation	18	6.59e-01	7.87e-01	0.09680	9.64e-02	-0.008700	4.79e-01	9.49e-01
Glyoxylate-metabolism-and-glycine-degradation	30	5.39e-01	6.90e-01	0.09660	1.54e-02	-0.095300	8.84e-01	3.66e-01
Transport-to-the-Golgi-and-subsequent-modification	161	1.06e-01	2.47e-01	0.09650	8.98e-02	-0.035200	4.91e-02	4.40e-01
Disorders-of-transmembrane-transporters	169	1.88e-01	3.60e-01	0.09590	5.10e-02	-0.081200	2.52e-01	6.82e-02
Extra-nuclear-estrogen-signaling	71	2.32e-01	4.08e-01	0.09570	9.47e-02	-0.014300	1.68e-01	8.35e-01
PI3K-Cascade	38	3.55e-01	5.30e-01	0.09540	-9.53e-02	-0.004490	3.09e-01	9.62e-01
Regulation-of-lipid-metabolism-by-PPARalpha	116	6.94e-03	3.56e-02	0.09520	-7.01e-02	-0.064400	1.92e-01	2.30e-01
NOTCH4-Activation-and-Transmission-of-Signal-to-the-Nucleus	10	9.16e-01	9.52e-01	0.09510	-7.65e-02	0.056500	6.75e-01	7.57e-01
ADORA2B-mediated-anti-inflammatory-cytokines-production	107	1.44e-01	3.05e-01	0.09460	-1.98e-02	0.092500	7.23e-01	9.83e-02
Transport-of-Mature-mRNA-derived-from-an-Intron-Containing-Transcript	71	5.74e-01	7.17e-01	0.09390	-6.68e-02	0.065900	3.30e-01	3.37e-01
Integration-of-energy-metabolism	104	2.57e-02	9.95e-02	0.09320	8.76e-02	0.031900	1.22e-01	5.74e-01
Amyloid-fiber-formation	44	4.88e-01	6.52e-01	0.09320	-2.35e-02	0.090200	7.87e-01	3.00e-01
Biosynthesis-of-specialized-proresolving-mediators-(SPMs)	17	5.26e-01	6.79e-01	0.09320	8.36e-02	0.041100	5.50e-01	7.69e-01
HIV-Life-Cycle	137	1.89e-01	3.60e-01	0.09320	8.54e-02	-0.037200	8.40e-02	4.52e-01
MTOR-signalling	41	4.83e-01	6.48e-01	0.09280	9.09e-02	-0.018700	3.14e-01	8.36e-01
Regulation-of-TP53-Activity	153	7.57e-02	1.98e-01	0.09270	9.03e-02	-0.020900	5.37e-02	6.56e-01
Rev-mediated-nuclear-export-of-HIV-RNA	33	3.52e-01	5.27e-01	0.09240	2.19e-02	0.089800	8.28e-01	3.72e-01
Pyroptosis	21	7.55e-01	8.48e-01	0.09230	8.66e-02	-0.031900	4.92e-01	8.00e-01
SHC-mediated-cascade:FGFR4	17	6.20e-01	7.54e-01	0.09200	-1.20e-02	-0.091200	9.32e-01	5.15e-01
NRAGE-signals-death-through-JNK	58	2.29e-01	4.06e-01	0.09170	4.79e-03	0.091600	9.50e-01	2.27e-01
FCGR3A-mediated-phagocytosis	69	2.77e-01	4.55e-01	0.09160	-9.05e-02	0.014400	1.93e-01	8.36e-01
Leishmania-phagocytosis	69	2.77e-01	4.55e-01	0.09160	-9.05e-02	0.014400	1.93e-01	8.36e-01
Parasite-infection	69	2.77e-01	4.55e-01	0.09160	-9.05e-02	0.014400	1.93e-01	8.36e-01
SUMOylation-of-DNA-replication-proteins	44	5.10e-01	6.67e-01	0.09150	8.82e-02	-0.024400	3.11e-01	7.79e-01
Arachidonic-acid-metabolism	46	2.78e-01	4.55e-01	0.09130	9.04e-02	0.012600	2.89e-01	8.82e-01
Apoptosis	159	2.90e-01	4.66e-01	0.09120	5.65e-02	-0.071500	2.18e-01	1.19e-01
Resolution-of-D-loop-Structures-through-Holliday-Junction-Intermediates	32	3.66e-01	5.43e-01	0.09080	8.75e-02	0.024200	3.91e-01	8.13e-01
Deubiquitination	232	2.91e-02	1.08e-01	0.09080	2.33e-02	-0.087800	5.41e-01	2.11e-02
Maturation-of-nucleoprotein	11	9.10e-01	9.50e-01	0.09080	5.00e-02	-0.075700	7.74e-01	6.64e-01
Nuclear-import-of-Rev-protein	31	3.00e-01	4.76e-01	0.09050	6.58e-02	0.062200	5.26e-01	5.49e-01
GABA-receptor-activation	53	6.19e-01	7.53e-01	0.09030	-4.66e-02	0.077300	5.57e-01	3.30e-01
G-protein-mediated-events	51	1.86e-01	3.60e-01	0.09020	3.08e-02	0.084800	7.03e-01	2.95e-01
DNA-Double-Strand-Break-Response	42	5.48e-01	6.93e-01	0.09010	-2.57e-02	0.086400	7.73e-01	3.33e-01
RUNX2-regulates-osteoblast-differentiation	24	4.76e-01	6.44e-01	0.08980	8.63e-02	0.024700	4.64e-01	8.34e-01
Nuclear-Envelope-Breakdown	51	2.93e-01	4.71e-01	0.08970	8.96e-02	0.004190	2.68e-01	9.59e-01
Defensins	18	5.95e-01	7.34e-01	0.08930	8.73e-02	0.018900	5.21e-01	8.89e-01
RHOU-GTPase-cycle	40	5.85e-01	7.26e-01	0.08920	8.48e-02	-0.027500	3.53e-01	7.63e-01
Regulation-of-actin-dynamics-for-phagocytic-cup-formation	71	3.30e-01	5.06e-01	0.08910	-8.68e-02	0.020100	2.06e-01	7.69e-01
Signaling-by-NTRKs	131	1.35e-01	2.94e-01	0.08890	-2.08e-02	0.086400	6.81e-01	8.75e-02
Effects-of-PIP2-hydrolysis	26	3.87e-01	5.62e-01	0.08880	5.09e-02	0.072700	6.53e-01	5.21e-01
Insulin-processing	26	3.88e-01	5.62e-01	0.08880	7.32e-02	0.050200	5.18e-01	6.58e-01
LDL-clearance	19	8.59e-01	9.24e-01	0.08830	7.30e-02	-0.049800	5.82e-01	7.07e-01
G-beta:gamma-signalling-through-PI3Kgamma	23	6.03e-01	7.40e-01	0.08820	4.63e-06	0.088200	1.00e+00	4.64e-01
G-alpha-(s)-signalling-events	117	7.00e-02	1.91e-01	0.08820	2.53e-03	0.088200	9.62e-01	9.92e-02
Meiotic-recombination	27	5.17e-01	6.75e-01	0.08740	8.70e-02	0.008600	4.34e-01	9.38e-01
Protein-folding	89	4.95e-01	6.57e-01	0.08720	4.82e-02	-0.072600	4.31e-01	2.36e-01
mRNA-Capping	29	3.85e-01	5.61e-01	0.08690	3.87e-02	0.077800	7.19e-01	4.68e-01
Transcriptional-activation-of-mitochondrial-biogenesis	51	3.72e-01	5.48e-01	0.08690	-8.67e-02	0.005590	2.84e-01	9.45e-01
Transport-of-Mature-Transcript-to-Cytoplasm	79	5.83e-01	7.25e-01	0.08680	-6.56e-02	0.056900	3.13e-01	3.82e-01
Disassembly-of-the-destruction-complex-and-recruitment-of-AXIN-to-the-membrane	29	3.84e-01	5.60e-01	0.08680	7.73e-02	0.039400	4.71e-01	7.13e-01
COPI-dependent-Golgi-to-ER-retrograde-traffic	78	2.00e-01	3.75e-01	0.08670	8.66e-02	-0.001540	1.86e-01	9.81e-01
Nuclear-Envelope-(NE)-Reassembly	68	1.51e-01	3.13e-01	0.08660	8.41e-02	0.020700	2.30e-01	7.68e-01
Cell-Cell-communication	110	2.02e-01	3.76e-01	0.08630	8.40e-02	-0.019700	1.28e-01	7.21e-01
mRNA-Splicing—Minor-Pathway	53	4.52e-01	6.22e-01	0.08620	1.83e-02	-0.084200	8.17e-01	2.89e-01
Diseases-of-metabolism	222	4.60e-02	1.45e-01	0.08620	-2.17e-02	0.083400	5.78e-01	3.20e-02
IRE1alpha-activates-chaperones	49	6.99e-01	8.12e-01	0.08550	-4.94e-02	0.069800	5.49e-01	3.98e-01
Negative-regulation-of-FGFR4-signaling	27	8.32e-01	9.02e-01	0.08520	5.31e-02	-0.066700	6.33e-01	5.49e-01
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes	29	7.07e-01	8.16e-01	0.08470	2.67e-02	-0.080300	8.04e-01	4.54e-01
Export-of-Viral-Ribonucleoproteins-from-Nucleus	31	3.74e-01	5.50e-01	0.08460	7.44e-02	0.040200	4.73e-01	6.99e-01
PI-3K-cascade:FGFR3	16	5.84e-01	7.26e-01	0.08460	-6.62e-02	-0.052600	6.47e-01	7.16e-01
Pre-NOTCH-Processing-in-Golgi	18	5.96e-01	7.34e-01	0.08420	2.88e-02	0.079100	8.33e-01	5.61e-01
Telomere-Maintenance	65	1.49e-01	3.11e-01	0.08360	7.71e-02	0.032300	2.82e-01	6.52e-01
Opioid-Signalling	84	8.30e-02	2.10e-01	0.08260	7.41e-02	0.036500	2.40e-01	5.63e-01
Activation-of-BH3-only-proteins	28	7.80e-01	8.70e-01	0.08250	3.61e-02	-0.074200	7.41e-01	4.97e-01
Extension-of-Telomeres	50	2.22e-01	3.95e-01	0.08230	3.98e-02	0.072000	6.26e-01	3.78e-01
Signaling-by-FGFR1	43	3.05e-01	4.83e-01	0.08220	-7.70e-02	-0.028900	3.82e-01	7.43e-01
Infectious-disease	735	1.27e-02	5.86e-02	0.08190	5.38e-02	-0.061700	1.27e-02	4.22e-03
Late-Phase-of-HIV-Life-Cycle	125	3.87e-01	5.62e-01	0.08180	7.06e-02	-0.041200	1.72e-01	4.25e-01
Recruitment-and-ATM-mediated-phosphorylation-of-repair-and-signaling-proteins-at-DNA-double-strand-breaks	41	5.44e-01	6.91e-01	0.08180	-1.28e-02	0.080800	8.88e-01	3.71e-01
HIV-Infection	214	2.86e-01	4.62e-01	0.08130	5.58e-02	-0.059100	1.59e-01	1.36e-01
Neurotransmitter-receptors-and-postsynaptic-signal-transmission	167	5.81e-03	3.10e-02	0.08130	6.41e-02	0.050000	1.53e-01	2.65e-01
Factors-involved-in-megakaryocyte-development-and-platelet-production	112	6.03e-02	1.74e-01	0.08110	2.18e-02	0.078100	6.89e-01	1.53e-01
Signaling-by-ERBB4	54	6.71e-01	7.96e-01	0.08110	4.14e-02	-0.069700	5.99e-01	3.75e-01
Erythropoietin-activates-RAS	14	8.66e-01	9.28e-01	0.08090	2.80e-02	-0.075900	8.56e-01	6.23e-01
Regulation-of-Complement-cascade	49	3.37e-01	5.13e-01	0.08070	-7.98e-02	-0.012500	3.34e-01	8.79e-01
Signaling-by-NOTCH	172	3.47e-01	5.23e-01	0.08050	-6.38e-02	0.049200	1.49e-01	2.66e-01
Pexophagy	10	7.46e-01	8.44e-01	0.08040	6.87e-02	0.041800	7.07e-01	8.19e-01
Downstream-signaling-of-activated-FGFR3	23	5.64e-01	7.07e-01	0.07970	-2.37e-02	-0.076100	8.44e-01	5.27e-01
FGFR2-alternative-splicing	26	7.04e-01	8.14e-01	0.07970	1.45e-02	-0.078300	8.98e-01	4.89e-01
Transcriptional-Regulation-by-VENTX	37	6.79e-01	8.01e-01	0.07960	-2.54e-02	0.075500	7.89e-01	4.27e-01
FRS-mediated-FGFR4-signaling	19	6.68e-01	7.93e-01	0.07950	-1.13e-02	-0.078700	9.32e-01	5.53e-01
Sphingolipid-metabolism	81	4.16e-01	5.86e-01	0.07940	-7.58e-02	0.023600	2.38e-01	7.13e-01
Prostacyclin-signalling-through-prostacyclin-receptor	18	6.13e-01	7.48e-01	0.07870	3.59e-02	0.070000	7.92e-01	6.07e-01
Platelet-activation,-signaling-and-aggregation	244	2.59e-01	4.37e-01	0.07860	-5.25e-02	0.058500	1.57e-01	1.15e-01
Processive-synthesis-on-the-C-strand-of-the-telomere	19	5.93e-01	7.32e-01	0.07830	6.80e-02	0.039000	6.08e-01	7.69e-01
Host-Interactions-of-HIV-factors	121	3.10e-01	4.89e-01	0.07830	2.67e-02	-0.073600	6.11e-01	1.62e-01
Killing-mechanisms	12	8.04e-01	8.87e-01	0.07810	-3.41e-03	-0.078000	9.84e-01	6.40e-01
WNT5:FZD7-mediated-leishmania-damping	12	8.04e-01	8.87e-01	0.07810	-3.41e-03	-0.078000	9.84e-01	6.40e-01
Negative-regulation-of-FGFR3-signaling	26	8.16e-01	8.97e-01	0.07810	6.99e-02	-0.034700	5.37e-01	7.59e-01
Frs2-mediated-activation	12	8.92e-01	9.42e-01	0.07790	-7.32e-02	0.026800	6.61e-01	8.72e-01
Inhibition-of-DNA-recombination-at-telomere	21	8.28e-01	9.02e-01	0.07770	7.21e-02	-0.028900	5.67e-01	8.18e-01
ER-to-Golgi-Anterograde-Transport	133	2.35e-01	4.11e-01	0.07750	7.46e-02	-0.020800	1.37e-01	6.78e-01
DNA-Damage-Recognition-in-GG-NER	37	6.66e-01	7.92e-01	0.07740	7.46e-02	-0.020400	4.32e-01	8.30e-01
Fcgamma-receptor-(FCGR)-dependent-phagocytosis	95	5.77e-01	7.20e-01	0.07730	-6.20e-02	0.046200	2.96e-01	4.36e-01
Phospholipase-C-mediated-cascade:-FGFR1	11	8.70e-01	9.30e-01	0.07730	-7.60e-02	0.014300	6.63e-01	9.34e-01
Cargo-recognition-for-clathrin-mediated-endocytosis	96	3.27e-01	5.04e-01	0.07730	1.78e-02	-0.075200	7.63e-01	2.03e-01
ERK/MAPK-targets	22	6.50e-01	7.80e-01	0.07710	9.68e-03	0.076500	9.37e-01	5.35e-01
RHO-GTPase-cycle	436	4.47e-03	2.55e-02	0.07700	-1.41e-02	0.075700	6.12e-01	6.60e-03
Metabolism-of-lipids	674	2.01e-03	1.30e-02	0.07690	2.59e-02	-0.072400	2.50e-01	1.30e-03
Acyl-chain-remodelling-of-PC	23	7.93e-01	8.80e-01	0.07560	2.15e-02	-0.072500	8.58e-01	5.47e-01
Nitric-oxide-stimulates-guanylate-cyclase	21	6.61e-01	7.88e-01	0.07550	7.44e-02	0.012700	5.55e-01	9.20e-01
Integrin-signaling	27	8.24e-01	9.02e-01	0.07550	3.42e-02	-0.067300	7.59e-01	5.45e-01
G-alpha-(q)-signalling-events	183	1.20e-02	5.56e-02	0.07550	3.10e-02	0.068800	4.69e-01	1.08e-01
Activation-of-AMPK-downstream-of-NMDARs	10	7.83e-01	8.72e-01	0.07510	3.26e-02	0.067700	8.59e-01	7.11e-01
Cytosolic-sulfonation-of-small-molecules	17	6.57e-01	7.86e-01	0.07500	3.42e-02	0.066800	8.07e-01	6.33e-01
FCERI-mediated-MAPK-activation	40	8.10e-01	8.92e-01	0.07490	-5.86e-02	0.046600	5.21e-01	6.10e-01
mTORC1-mediated-signalling	24	8.32e-01	9.02e-01	0.07480	3.08e-02	-0.068100	7.94e-01	5.63e-01
Lysosome-Vesicle-Biogenesis	34	5.43e-01	6.91e-01	0.07470	-7.43e-02	-0.007790	4.53e-01	9.37e-01
DNA-Double-Strand-Break-Repair	129	3.59e-02	1.26e-01	0.07470	4.30e-02	0.061100	3.98e-01	2.31e-01
Formation-of-TC-NER-Pre-Incision-Complex	52	6.02e-01	7.39e-01	0.07450	7.14e-02	-0.021300	3.73e-01	7.90e-01
Beta-catenin-independent-WNT-signaling	140	1.09e-01	2.52e-01	0.07450	-9.10e-04	-0.074500	9.85e-01	1.28e-01
EGFR-downregulation	29	4.67e-01	6.38e-01	0.07440	-5.41e-02	-0.051000	6.14e-01	6.34e-01
FGFR3-mutant-receptor-activation	10	8.32e-01	9.02e-01	0.07430	-7.36e-02	-0.009890	6.87e-01	9.57e-01
Signaling-by-activated-point-mutants-of-FGFR3	10	8.32e-01	9.02e-01	0.07430	-7.36e-02	-0.009890	6.87e-01	9.57e-01
Signaling-by-EGFR	48	3.80e-01	5.56e-01	0.07420	-7.23e-02	-0.016700	3.86e-01	8.42e-01
Metabolism-of-proteins	1703	3.27e-04	3.05e-03	0.07420	4.85e-02	-0.056100	7.70e-04	1.01e-04
IGF1R-signaling-cascade	47	3.15e-01	4.93e-01	0.07420	-6.46e-02	-0.036500	4.44e-01	6.65e-01
Gene-Silencing-by-RNA	74	2.10e-01	3.83e-01	0.07420	7.13e-02	0.020500	2.89e-01	7.61e-01
Nucleobase-catabolism	33	8.31e-01	9.02e-01	0.07390	6.13e-02	-0.041300	5.42e-01	6.82e-01
IRS-mediated-signalling	42	3.46e-01	5.22e-01	0.07380	-6.02e-02	-0.042700	5.00e-01	6.32e-01
Chaperonin-mediated-protein-folding	84	5.65e-01	7.07e-01	0.07360	3.34e-02	-0.065600	5.96e-01	2.99e-01
Homology-Directed-Repair	100	1.38e-01	2.95e-01	0.07360	7.17e-02	0.016700	2.15e-01	7.73e-01
IRS-related-events-triggered-by-IGF1R	46	3.08e-01	4.86e-01	0.07350	-5.03e-02	-0.053600	5.55e-01	5.29e-01
RAF/MAP-kinase-cascade	263	2.90e-02	1.08e-01	0.07340	5.72e-03	-0.073200	8.73e-01	4.08e-02
Estrogen-dependent-gene-expression	90	4.71e-01	6.40e-01	0.07330	-6.87e-02	0.025600	2.59e-01	6.75e-01
Nucleotide-like-(purinergic)-receptors	15	6.91e-01	8.09e-01	0.07320	-4.05e-02	-0.061000	7.86e-01	6.82e-01
Signaling-by-Type-1-Insulin-like-Growth-Factor-1-Receptor-(IGF1R)	48	3.07e-01	4.86e-01	0.07210	-5.42e-02	-0.047600	5.16e-01	5.68e-01
Vesicle-mediated-transport	625	2.18e-02	8.75e-02	0.07180	6.33e-02	-0.034000	6.70e-03	1.46e-01
NR1H3-&-NR1H2-regulate-gene-expression-linked-to-cholesterol-transport-and-efflux	34	5.36e-01	6.88e-01	0.07180	1.41e-02	0.070400	8.87e-01	4.77e-01
Defective-TPR-may-confer-susceptibility-towards-thyroid-papillary-carcinoma-(TPC)	30	6.14e-01	7.48e-01	0.07180	7.15e-02	0.006210	4.98e-01	9.53e-01
Regulation-of-Glucokinase-by-Glucokinase-Regulatory-Protein	30	6.14e-01	7.48e-01	0.07180	7.15e-02	0.006210	4.98e-01	9.53e-01
Global-Genome-Nucleotide-Excision-Repair-(GG-NER)	82	1.37e-01	2.94e-01	0.07170	4.74e-02	0.053700	4.57e-01	4.00e-01
Vasopressin-regulates-renal-water-homeostasis-via-Aquaporins	40	6.10e-01	7.46e-01	0.07120	7.09e-02	-0.007140	4.38e-01	9.38e-01
Uptake-and-actions-of-bacterial-toxins	29	5.19e-01	6.75e-01	0.07110	-3.50e-02	-0.061900	7.44e-01	5.64e-01
Interleukin-7-signaling	21	6.43e-01	7.75e-01	0.07090	-6.55e-02	-0.027100	6.03e-01	8.30e-01
Degradation-of-cysteine-and-homocysteine	14	9.13e-01	9.51e-01	0.07090	-6.37e-02	0.031000	6.80e-01	8.41e-01
RNA-polymerase-II-transcribes-snRNA-genes	77	2.21e-01	3.95e-01	0.07030	-2.20e-02	-0.066800	7.39e-01	3.10e-01
NEP/NS2-Interacts-with-the-Cellular-Export-Machinery	30	4.96e-01	6.58e-01	0.07020	4.75e-02	0.051600	6.52e-01	6.24e-01
Signaling-by-TGF-beta-Receptor-Complex	71	2.18e-01	3.92e-01	0.06960	-3.30e-02	-0.061300	6.30e-01	3.72e-01
FGFR1-mutant-receptor-activation	27	5.40e-01	6.91e-01	0.06950	-5.20e-02	-0.046000	6.40e-01	6.79e-01
Detoxification-of-Reactive-Oxygen-Species	34	4.90e-01	6.54e-01	0.06940	-3.07e-02	-0.062300	7.57e-01	5.30e-01
Cell-recruitment-(pro-inflammatory-response)	24	9.00e-01	9.47e-01	0.06930	-4.45e-02	0.053000	7.06e-01	6.53e-01
Purinergic-signaling-in-leishmaniasis-infection	24	9.00e-01	9.47e-01	0.06930	-4.45e-02	0.053000	7.06e-01	6.53e-01
Signaling-by-FGFR	78	1.72e-01	3.41e-01	0.06920	-5.30e-02	-0.044400	4.18e-01	4.98e-01
Nuclear-Events-(kinase-and-transcription-factor-activation)	61	7.43e-01	8.43e-01	0.06900	-5.70e-02	0.038900	4.41e-01	5.99e-01
Tristetraprolin-(TTP,-ZFP36)-binds-and-destabilizes-mRNA	16	7.03e-01	8.14e-01	0.06820	-5.15e-02	-0.044700	7.21e-01	7.57e-01
Signaling-by-NTRK1-(TRKA)	112	5.45e-01	6.92e-01	0.06750	-3.24e-02	0.059200	5.53e-01	2.79e-01
Neutrophil-degranulation	420	1.46e-01	3.06e-01	0.06720	3.77e-02	-0.055700	1.85e-01	4.98e-02
Leishmania-infection	233	2.83e-01	4.59e-01	0.06710	-3.17e-02	0.059200	4.03e-01	1.19e-01
SHC-mediated-cascade:FGFR1	16	9.26e-01	9.57e-01	0.06710	-5.64e-02	0.036400	6.96e-01	8.01e-01
SUMOylation-of-SUMOylation-proteins	33	7.53e-01	8.48e-01	0.06710	6.51e-02	-0.016200	5.18e-01	8.72e-01
Death-Receptor-Signalling	132	4.13e-01	5.82e-01	0.06650	6.21e-02	-0.024000	2.18e-01	6.34e-01
SUMOylation-of-RNA-binding-proteins	45	8.13e-01	8.95e-01	0.06650	-5.53e-02	0.036800	5.21e-01	6.69e-01
ISG15-antiviral-mechanism	64	7.25e-01	8.27e-01	0.06640	3.34e-02	-0.057400	6.44e-01	4.27e-01
STAT5-activation-downstream-of-FLT3-ITD-mutants	10	9.61e-01	9.72e-01	0.06640	4.93e-02	-0.044600	7.87e-01	8.07e-01
Purine-catabolism	16	9.11e-01	9.51e-01	0.06630	-5.99e-02	0.028600	6.78e-01	8.43e-01
HDR-through-Homologous-Recombination-(HRR)-or-Single-Strand-Annealing-(SSA)	94	3.54e-01	5.30e-01	0.06560	6.55e-02	-0.004220	2.72e-01	9.44e-01
Regulation-of-localization-of-FOXO-transcription-factors	11	9.54e-01	9.68e-01	0.06520	3.75e-02	-0.053400	8.30e-01	7.59e-01
Meiotic-synapsis	31	6.74e-01	7.98e-01	0.06480	-3.58e-03	-0.064700	9.72e-01	5.33e-01
Signaling-by-NODAL	17	8.97e-01	9.47e-01	0.06470	2.32e-02	-0.060300	8.68e-01	6.67e-01
Adaptive-Immune-System	672	8.06e-02	2.06e-01	0.06460	-4.95e-02	0.041500	2.81e-02	6.55e-02
EPH-ephrin-mediated-repulsion-of-cells	44	4.21e-01	5.90e-01	0.06440	4.31e-02	0.047900	6.21e-01	5.83e-01
Termination-of-translesion-DNA-synthesis	30	5.63e-01	7.07e-01	0.06410	5.17e-02	0.037900	6.24e-01	7.19e-01
Intra-Golgi-traffic	41	5.36e-01	6.88e-01	0.06380	6.18e-02	0.015700	4.94e-01	8.61e-01
Peptide-ligand-binding-receptors	146	4.37e-01	6.08e-01	0.06360	-2.53e-02	0.058300	5.97e-01	2.24e-01
Activation-of-GABAB-receptors	41	8.32e-01	9.02e-01	0.06340	-5.43e-02	0.032600	5.47e-01	7.18e-01
GABA-B-receptor-activation	41	8.32e-01	9.02e-01	0.06340	-5.43e-02	0.032600	5.47e-01	7.18e-01
Synthesis-of-substrates-in-N-glycan-biosythesis	57	5.64e-01	7.07e-01	0.06320	-4.93e-03	0.063000	9.49e-01	4.11e-01
mRNA-Splicing	185	6.73e-02	1.86e-01	0.06310	-1.46e-02	-0.061300	7.32e-01	1.50e-01
Antigen-Presentation:-Folding,-assembly-and-peptide-loading-of-class-I-MHC	17	9.37e-01	9.59e-01	0.06290	5.05e-02	-0.037500	7.18e-01	7.89e-01
FOXO-mediated-transcription	61	6.86e-01	8.06e-01	0.06260	2.14e-02	-0.058900	7.72e-01	4.26e-01
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain	19	9.33e-01	9.58e-01	0.06210	4.88e-02	-0.038400	7.13e-01	7.72e-01
MAPK1/MAPK3-signaling	269	5.46e-02	1.63e-01	0.06200	-2.83e-04	-0.062000	9.94e-01	7.97e-02
FRS-mediated-FGFR1-signaling	18	9.33e-01	9.58e-01	0.06180	-5.07e-02	0.035400	7.10e-01	7.95e-01
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein	70	6.67e-01	7.93e-01	0.06170	-2.22e-02	0.057500	7.48e-01	4.05e-01
Amine-ligand-binding-receptors	30	5.98e-01	7.37e-01	0.06160	5.30e-02	0.031400	6.15e-01	7.66e-01
Intrinsic-Pathway-for-Apoptosis	47	7.56e-01	8.48e-01	0.06150	5.78e-02	-0.021000	4.93e-01	8.03e-01
Class-A/1-(Rhodopsin-like-receptors)	254	7.64e-02	1.98e-01	0.06140	-1.82e-03	0.061400	9.60e-01	9.16e-02
Formation-of-Incision-Complex-in-GG-NER	41	7.23e-01	8.26e-01	0.06110	-1.12e-02	0.060000	9.01e-01	5.06e-01
Ion-transport-by-P-type-ATPases	53	4.45e-01	6.15e-01	0.06090	5.69e-02	0.021900	4.74e-01	7.82e-01
Class-B/2-(Secretin-family-receptors)	79	2.72e-01	4.51e-01	0.06080	5.29e-02	0.030000	4.16e-01	6.45e-01
Transcriptional-regulation-by-RUNX1	171	1.49e-01	3.11e-01	0.06070	-6.06e-02	-0.003430	1.71e-01	9.38e-01
Activation-of-BAD-and-translocation-to-mitochondria	14	8.84e-01	9.37e-01	0.05980	5.70e-03	-0.059500	9.71e-01	7.00e-01
GPCR-downstream-signalling	513	8.58e-04	6.62e-03	0.05970	1.80e-02	0.056900	4.85e-01	2.69e-02
MicroRNA-(miRNA)-biogenesis	24	6.90e-01	8.09e-01	0.05930	2.73e-02	0.052700	8.17e-01	6.55e-01
ERKs-are-inactivated	13	8.08e-01	8.91e-01	0.05920	4.76e-02	0.035200	7.66e-01	8.26e-01
Estrogen-dependent-nuclear-events-downstream-of-ESR-membrane-signaling	23	6.83e-01	8.04e-01	0.05920	4.50e-02	0.038400	7.09e-01	7.50e-01
Insulin-receptor-signalling-cascade	48	4.54e-01	6.24e-01	0.05900	-4.44e-02	-0.038900	5.95e-01	6.41e-01
Complement-cascade	57	4.97e-01	6.58e-01	0.05880	-5.77e-02	-0.011400	4.51e-01	8.82e-01
Signaling-by-GPCR	575	1.70e-04	1.73e-03	0.05870	2.86e-02	0.051300	2.40e-01	3.49e-02
ADP-signalling-through-P2Y-purinoceptor-1	24	6.87e-01	8.08e-01	0.05860	3.08e-02	0.049900	7.94e-01	6.72e-01
Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism	13	8.28e-01	9.02e-01	0.05850	-5.37e-02	-0.023300	7.38e-01	8.84e-01
HSP90-chaperone-cycle-for-steroid-hormone-receptors-(SHR)-in-the-presence-of-ligand	35	5.87e-01	7.27e-01	0.05840	2.84e-02	0.051100	7.71e-01	6.01e-01
Potassium-Channels	92	2.51e-01	4.27e-01	0.05830	5.13e-02	0.027600	3.95e-01	6.47e-01
Innate-Immune-System	899	7.08e-02	1.91e-01	0.05810	3.87e-02	-0.043300	4.80e-02	2.70e-02
HATs-acetylate-histones	80	7.54e-01	8.48e-01	0.05790	-3.16e-02	0.048500	6.25e-01	4.53e-01
HCMV-Infection	79	4.82e-01	6.48e-01	0.05760	5.76e-02	-0.000387	3.76e-01	9.95e-01
Antiviral-mechanism-by-IFN-stimulated-genes	72	7.38e-01	8.39e-01	0.05720	2.52e-02	-0.051300	7.11e-01	4.51e-01
Signaling-by-PDGFRA-extracellular-domain-mutants	12	8.31e-01	9.02e-01	0.05710	3.73e-02	0.043200	8.23e-01	7.95e-01
Signaling-by-PDGFRA-transmembrane,-juxtamembrane-and-kinase-domain-mutants	12	8.31e-01	9.02e-01	0.05710	3.73e-02	0.043200	8.23e-01	7.95e-01
Digestion	11	9.41e-01	9.62e-01	0.05690	5.43e-02	-0.016900	7.55e-01	9.23e-01
GPCR-ligand-binding	353	1.64e-02	7.11e-02	0.05630	1.35e-02	0.054700	6.64e-01	7.70e-02
Activation-of-kainate-receptors-upon-glutamate-binding	28	6.59e-01	7.87e-01	0.05600	3.95e-02	0.039700	7.17e-01	7.16e-01
RHO-GTPases-activate-IQGAPs	11	9.60e-01	9.72e-01	0.05560	2.66e-02	-0.048800	8.78e-01	7.79e-01
HSF1-dependent-transactivation	32	7.14e-01	8.21e-01	0.05520	-5.44e-02	-0.009300	5.94e-01	9.27e-01
COPII-mediated-vesicle-transport	68	8.32e-01	9.02e-01	0.05490	3.70e-02	-0.040600	5.97e-01	5.63e-01
p75-NTR-receptor-mediated-signalling	92	5.49e-01	6.93e-01	0.05470	5.39e-02	-0.009180	3.71e-01	8.79e-01
Nucleotide-Excision-Repair	108	2.59e-01	4.36e-01	0.05470	5.04e-02	0.021300	3.66e-01	7.03e-01
MAPK-family-signaling-cascades	306	6.98e-02	1.91e-01	0.05410	-2.56e-03	-0.054000	9.39e-01	1.03e-01
Oxidative-Stress-Induced-Senescence	62	7.86e-01	8.75e-01	0.05400	-4.89e-02	0.022900	5.06e-01	7.55e-01
Inwardly-rectifying-K+-channels	34	9.08e-01	9.50e-01	0.05350	-4.34e-02	0.031300	6.61e-01	7.52e-01
Defects-in-cobalamin-(B12)-metabolism	12	8.61e-01	9.24e-01	0.05340	-4.75e-02	-0.024400	7.76e-01	8.84e-01
TNFs-bind-their-physiological-receptors	24	7.30e-01	8.33e-01	0.05270	4.02e-02	0.034100	7.33e-01	7.73e-01
XBP1(S)-activates-chaperone-genes	47	8.38e-01	9.07e-01	0.05260	-2.19e-02	0.047800	7.95e-01	5.71e-01
Cytochrome-P450—arranged-by-substrate-type	48	8.90e-01	9.41e-01	0.05230	-3.68e-02	0.037200	6.59e-01	6.55e-01
Transport-of-vitamins,-nucleosides,-and-related-molecules	37	6.35e-01	7.67e-01	0.05210	-2.70e-02	-0.044500	7.76e-01	6.39e-01
Hemostasis	535	1.98e-02	8.16e-02	0.05210	-8.66e-04	0.052100	9.73e-01	3.89e-02
GAB1-signalosome	16	9.18e-01	9.53e-01	0.05200	-5.07e-02	0.011600	7.26e-01	9.36e-01
P2Y-receptors	11	8.72e-01	9.31e-01	0.05190	-2.89e-02	-0.043100	8.68e-01	8.04e-01
DNA-Repair	276	3.68e-02	1.27e-01	0.05190	4.50e-02	0.025800	1.98e-01	4.60e-01
Signaling-by-FGFR3	37	8.40e-01	9.08e-01	0.05180	1.49e-02	-0.049600	8.75e-01	6.01e-01
O-linked-glycosylation-of-mucins	52	6.21e-01	7.55e-01	0.05160	8.39e-03	0.050900	9.17e-01	5.25e-01
Purine-salvage	13	9.03e-01	9.48e-01	0.05140	-1.95e-03	-0.051400	9.90e-01	7.48e-01
Signaling-by-NTRK2-(TRKB)	25	7.32e-01	8.34e-01	0.05140	3.44e-02	0.038100	7.66e-01	7.42e-01
Retrograde-neurotrophin-signalling	14	8.92e-01	9.42e-01	0.05110	5.10e-02	0.003950	7.41e-01	9.80e-01
DNA-Damage/Telomere-Stress-Induced-Senescence	28	7.74e-01	8.64e-01	0.05060	9.99e-03	0.049600	9.27e-01	6.49e-01
Ethanol-oxidation	10	9.08e-01	9.50e-01	0.05050	4.86e-02	0.013400	7.90e-01	9.41e-01
Oncogene-Induced-Senescence	31	7.36e-01	8.37e-01	0.05040	-1.48e-02	-0.048100	8.86e-01	6.43e-01
Processing-of-SMDT1	15	9.67e-01	9.75e-01	0.05040	-3.69e-02	0.034300	8.05e-01	8.18e-01
Formation-of-RNA-Pol-II-elongation-complex	54	5.27e-01	6.79e-01	0.05030	3.13e-02	0.039300	6.90e-01	6.17e-01
RNA-Polymerase-II-Transcription-Elongation	54	5.27e-01	6.79e-01	0.05030	3.13e-02	0.039300	6.90e-01	6.17e-01
Platelet-degranulation	118	7.52e-01	8.48e-01	0.05020	4.00e-02	-0.030400	4.53e-01	5.68e-01
Negative-regulation-of-MET-activity	20	8.26e-01	9.02e-01	0.04990	-4.80e-02	-0.013600	7.10e-01	9.16e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE	73	5.41e-01	6.91e-01	0.04960	4.90e-02	0.007850	4.69e-01	9.08e-01
mRNA-Splicing—Major-Pathway	175	1.35e-01	2.94e-01	0.04950	-3.90e-02	-0.030400	3.73e-01	4.87e-01
Metabolism-of-vitamins-and-cofactors	168	4.25e-01	5.93e-01	0.04900	-4.82e-02	0.008800	2.81e-01	8.44e-01
Diseases-of-signal-transduction-by-growth-factor-receptors-and-second-messengers	412	1.38e-02	6.26e-02	0.04860	-4.24e-02	-0.023800	1.39e-01	4.07e-01
Class-I-MHC-mediated-antigen-processing-&-presentation	353	2.08e-02	8.48e-02	0.04850	-3.10e-02	-0.037300	3.16e-01	2.28e-01
Activation-of-the-pre-replicative-complex	32	7.37e-01	8.38e-01	0.04850	4.56e-02	0.016500	6.55e-01	8.71e-01
G-alpha-(i)-signalling-events	248	1.09e-01	2.52e-01	0.04810	1.40e-02	0.046100	7.04e-01	2.11e-01
Rab-regulation-of-trafficking	119	7.39e-01	8.39e-01	0.04790	4.10e-02	-0.024800	4.40e-01	6.40e-01
Glycogen-storage-diseases	13	9.73e-01	9.79e-01	0.04790	3.57e-02	-0.032000	8.24e-01	8.42e-01
Signaling-by-Rho-GTPases,-Miro-GTPases-and-RHOBTB3	622	2.83e-03	1.76e-02	0.04740	4.31e-02	0.019700	6.54e-02	3.99e-01
Antigen-processing:-Ubiquitination-&-Proteasome-degradation	295	5.24e-02	1.58e-01	0.04690	-2.57e-02	-0.039200	4.47e-01	2.46e-01
Processing-of-Capped-Intron-Containing-Pre-mRNA	235	9.59e-02	2.32e-01	0.04650	-3.78e-02	-0.027100	3.17e-01	4.74e-01
Anchoring-of-the-basal-body-to-the-plasma-membrane	92	6.44e-01	7.76e-01	0.04610	4.56e-02	-0.006770	4.50e-01	9.11e-01
Platelet-Aggregation-(Plug-Formation)	37	7.12e-01	8.20e-01	0.04610	-1.99e-02	-0.041500	8.34e-01	6.62e-01
G2/M-DNA-damage-checkpoint	59	6.56e-01	7.85e-01	0.04560	4.50e-02	0.007410	5.50e-01	9.22e-01
Telomere-Extension-By-Telomerase	22	9.23e-01	9.56e-01	0.04550	-4.37e-02	0.013000	7.23e-01	9.16e-01
Heme-degradation	14	9.71e-01	9.77e-01	0.04530	3.76e-02	-0.025200	8.07e-01	8.70e-01
Visual-phototransduction	85	5.47e-01	6.93e-01	0.04490	-8.36e-03	-0.044100	8.94e-01	4.81e-01
MAPK-targets/-Nuclear-events-mediated-by-MAP-kinases	31	8.47e-01	9.14e-01	0.04490	4.49e-02	-0.001870	6.65e-01	9.86e-01
Signaling-by-Retinoic-Acid	39	9.32e-01	9.58e-01	0.04470	-3.34e-02	0.029700	7.18e-01	7.48e-01
EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination	27	9.34e-01	9.58e-01	0.04460	-3.98e-02	0.020200	7.20e-01	8.56e-01
Negative-regulation-of-the-PI3K/AKT-network	106	7.63e-01	8.56e-01	0.04370	-1.85e-02	0.039600	7.42e-01	4.81e-01
Diseases-of-programmed-cell-death	42	8.00e-01	8.87e-01	0.04360	-4.36e-02	0.000200	6.25e-01	9.98e-01
Postmitotic-nuclear-pore-complex-(NPC)-reformation	27	9.32e-01	9.58e-01	0.04350	1.77e-02	-0.039700	8.73e-01	7.21e-01
Signaling-by-Rho-GTPases	607	5.17e-03	2.84e-02	0.04330	3.34e-02	0.027600	1.59e-01	2.44e-01
PI5P,-PP2A-and-IER3-Regulate-PI3K/AKT-Signaling	99	7.54e-01	8.48e-01	0.04320	-1.55e-02	0.040400	7.90e-01	4.87e-01
SHC-mediated-cascade:FGFR3	16	9.49e-01	9.68e-01	0.04240	1.12e-02	-0.040900	9.38e-01	7.77e-01
Signal-Transduction	2281	4.57e-05	6.00e-04	0.04160	-7.98e-04	0.041600	9.50e-01	9.60e-04
PTEN-Regulation	136	3.66e-01	5.43e-01	0.04140	-3.73e-02	-0.018000	4.52e-01	7.17e-01
Synthesis-of-bile-acids-and-bile-salts-via-27-hydroxycholesterol	12	9.16e-01	9.52e-01	0.04130	-1.75e-02	-0.037500	9.16e-01	8.22e-01
Signaling-by-Nuclear-Receptors	226	7.09e-01	8.18e-01	0.04130	3.07e-02	-0.027600	4.26e-01	4.75e-01
Formation-of-Fibrin-Clot-(Clotting-Cascade)	37	9.06e-01	9.49e-01	0.04040	1.30e-02	-0.038200	8.91e-01	6.87e-01
Unfolded-Protein-Response-(UPR)	88	5.86e-01	7.26e-01	0.04020	-3.89e-02	-0.010200	5.28e-01	8.68e-01
Translocation-of-SLC2A4-(GLUT4)-to-the-plasma-membrane	50	6.83e-01	8.04e-01	0.04020	3.10e-02	0.025600	7.05e-01	7.54e-01
G1/S-Specific-Transcription	28	9.04e-01	9.49e-01	0.04000	-3.96e-02	0.006080	7.17e-01	9.56e-01
SUMOylation-of-ubiquitinylation-proteins	37	7.57e-01	8.49e-01	0.03980	2.83e-02	0.028000	7.66e-01	7.68e-01
Metabolism-of-steroid-hormones	30	8.10e-01	8.92e-01	0.03890	-2.27e-02	-0.031600	8.30e-01	7.64e-01
PKMTs-methylate-histone-lysines	39	8.86e-01	9.38e-01	0.03870	7.72e-03	-0.038000	9.33e-01	6.82e-01
Signal-amplification	31	8.65e-01	9.27e-01	0.03870	3.19e-03	0.038500	9.75e-01	7.10e-01
Meiosis	56	9.27e-01	9.57e-01	0.03840	2.94e-02	-0.024600	7.03e-01	7.50e-01
Asparagine-N-linked-glycosylation	271	6.90e-01	8.09e-01	0.03830	-2.38e-02	0.030100	5.00e-01	3.94e-01
SARS-CoV-2-Infection	68	8.97e-01	9.47e-01	0.03790	-1.96e-02	0.032400	7.80e-01	6.44e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes	37	8.40e-01	9.08e-01	0.03730	5.50e-03	0.036900	9.54e-01	6.98e-01
RAB-GEFs-exchange-GTP-for-GDP-on-RABs	88	8.54e-01	9.21e-01	0.03720	-3.34e-02	0.016400	5.88e-01	7.91e-01
Transport-of-the-SLBP-Dependant-Mature-mRNA	34	8.65e-01	9.27e-01	0.03700	2.77e-03	0.036900	9.78e-01	7.09e-01
Transcriptional-regulation-of-white-adipocyte-differentiation	79	6.61e-01	7.88e-01	0.03680	-3.53e-02	-0.010500	5.87e-01	8.72e-01
Metabolism-of-water-soluble-vitamins-and-cofactors	109	6.94e-01	8.09e-01	0.03680	-3.66e-02	0.003180	5.09e-01	9.54e-01
Eicosanoid-ligand-binding-receptors	14	9.27e-01	9.57e-01	0.03470	-2.97e-02	-0.017900	8.48e-01	9.08e-01
Signaling-by-Non-Receptor-Tyrosine-Kinases	52	8.61e-01	9.24e-01	0.03460	3.44e-02	-0.003650	6.68e-01	9.64e-01
Signaling-by-PTK6	52	8.61e-01	9.24e-01	0.03460	3.44e-02	-0.003650	6.68e-01	9.64e-01
FRS-mediated-FGFR3-signaling	18	9.62e-01	9.72e-01	0.03460	9.46e-03	-0.033300	9.45e-01	8.07e-01
Transcription-of-E2F-targets-under-negative-control-by-DREAM-complex	19	9.16e-01	9.52e-01	0.03400	1.10e-02	0.032100	9.34e-01	8.08e-01
activated-TAK1-mediates-p38-MAPK-activation	18	9.29e-01	9.58e-01	0.03330	-7.93e-03	-0.032300	9.54e-01	8.12e-01
Signaling-by-KIT-in-disease	20	9.02e-01	9.48e-01	0.03320	2.07e-02	0.025900	8.73e-01	8.41e-01
Signaling-by-phosphorylated-juxtamembrane,-extracellular-and-kinase-domain-KIT-mutants	20	9.02e-01	9.48e-01	0.03320	2.07e-02	0.025900	8.73e-01	8.41e-01
Defects-of-contact-activation-system-(CAS)-and-kallikrein/kinin-system-(KKS)	16	9.27e-01	9.57e-01	0.03320	1.40e-02	0.030100	9.23e-01	8.35e-01
Diseases-of-hemostasis	16	9.27e-01	9.57e-01	0.03320	1.40e-02	0.030100	9.23e-01	8.35e-01
Transport-of-Mature-mRNAs-Derived-from-Intronless-Transcripts	40	8.29e-01	9.02e-01	0.03300	1.40e-02	0.029900	8.78e-01	7.44e-01
Disease	1478	2.01e-01	3.76e-01	0.03290	2.76e-02	-0.017900	7.36e-02	2.45e-01
Gap-junction-trafficking	24	9.15e-01	9.52e-01	0.03290	-3.25e-02	-0.005360	7.83e-01	9.64e-01
Transcription-of-E2F-targets-under-negative-control-by-p107-(RBL1)-and-p130-(RBL2)-in-complex-with-HDAC1	16	9.72e-01	9.78e-01	0.03250	-1.02e-02	0.030800	9.43e-01	8.31e-01
RNA-Polymerase-II-Pre-transcription-Events	75	9.33e-01	9.58e-01	0.03230	-2.22e-02	0.023400	7.39e-01	7.26e-01
Signaling-by-Interleukins	409	2.08e-01	3.82e-01	0.03140	-2.99e-02	-0.009630	2.99e-01	7.38e-01
Metabolism-of-fat-soluble-vitamins	41	8.51e-01	9.17e-01	0.03110	-2.92e-02	-0.010800	7.46e-01	9.05e-01
Transport-of-Mature-mRNA-Derived-from-an-Intronless-Transcript	39	8.37e-01	9.06e-01	0.03110	2.29e-02	0.020900	8.04e-01	8.21e-01
Negative-regulation-of-FGFR1-signaling	26	8.98e-01	9.47e-01	0.03100	2.83e-02	0.012800	8.03e-01	9.10e-01
Activation-of-G-protein-gated-Potassium-channels	28	8.80e-01	9.35e-01	0.03100	-2.19e-02	-0.022000	8.41e-01	8.41e-01
G-protein-gated-Potassium-channels	28	8.80e-01	9.35e-01	0.03100	-2.19e-02	-0.022000	8.41e-01	8.41e-01
Inhibition–of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits	28	8.80e-01	9.35e-01	0.03100	-2.19e-02	-0.022000	8.41e-01	8.41e-01
Sulfur-amino-acid-metabolism	27	9.62e-01	9.72e-01	0.03070	1.10e-02	-0.028700	9.21e-01	7.96e-01
Signaling-by-ALK-fusions-and-activated-point-mutants	52	9.50e-01	9.68e-01	0.03050	1.66e-02	-0.025600	8.36e-01	7.49e-01
Signaling-by-ALK-in-cancer	52	9.50e-01	9.68e-01	0.03050	1.66e-02	-0.025600	8.36e-01	7.49e-01
Constitutive-Signaling-by-AKT1-E17K-in-Cancer	26	9.75e-01	9.80e-01	0.03010	1.62e-02	-0.025400	8.87e-01	8.23e-01
Ephrin-signaling	17	9.34e-01	9.58e-01	0.02960	2.47e-02	0.016400	8.60e-01	9.07e-01
Transport-of-the-SLBP-independent-Mature-mRNA	33	8.82e-01	9.36e-01	0.02960	1.30e-02	0.026600	8.97e-01	7.92e-01
Surfactant-metabolism	23	9.82e-01	9.86e-01	0.02910	1.81e-02	-0.022800	8.81e-01	8.50e-01
Insertion-of-tail-anchored-proteins-into-the-endoplasmic-reticulum-membrane	20	9.61e-01	9.72e-01	0.02890	-3.45e-03	0.028700	9.79e-01	8.24e-01
Cooperation-of-PDCL-(PhLP1)-and-TRiC/CCT-in-G-protein-beta-folding	36	8.82e-01	9.36e-01	0.02780	-2.39e-02	-0.014200	8.04e-01	8.83e-01
Processing-of-DNA-double-strand-break-ends	61	9.03e-01	9.48e-01	0.02760	2.73e-02	-0.004450	7.13e-01	9.52e-01
Gap-junction-trafficking-and-regulation	26	9.30e-01	9.58e-01	0.02660	8.31e-03	0.025300	9.42e-01	8.23e-01
Response-to-elevated-platelet-cytosolic-Ca2+	123	9.20e-01	9.54e-01	0.02660	1.60e-02	-0.021200	7.59e-01	6.85e-01
HIV-Transcription-Initiation	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-HIV-Promoter-Escape	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Promoter-Escape	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Transcription-Initiation	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Transcription-Initiation-And-Promoter-Clearance	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Transcription-Pre-Initiation-And-Promoter-Opening	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
Signaling-by-WNT	257	7.69e-01	8.60e-01	0.02620	2.44e-02	-0.009650	5.00e-01	7.90e-01
Intrinsic-Pathway-of-Fibrin-Clot-Formation	22	9.45e-01	9.66e-01	0.02360	-1.94e-02	-0.013400	8.75e-01	9.13e-01
Gene-expression-(Transcription)	1158	2.09e-01	3.82e-01	0.02330	-2.32e-02	0.001300	1.80e-01	9.40e-01
Cytosolic-sensors-of-pathogen-associated-DNA	58	8.76e-01	9.33e-01	0.02320	9.40e-03	0.021300	9.01e-01	7.79e-01
Retinoid-metabolism-and-transport	38	9.09e-01	9.50e-01	0.02300	-1.57e-02	-0.016800	8.67e-01	8.58e-01
Cellular-response-to-heat-stress	92	9.31e-01	9.58e-01	0.02250	-2.10e-02	0.008080	7.27e-01	8.93e-01
tRNA-processing-in-the-nucleus	55	9.53e-01	9.68e-01	0.02230	6.55e-03	-0.021400	9.33e-01	7.84e-01
RNA-Polymerase-II-Transcription	1027	1.93e-01	3.67e-01	0.02220	-2.20e-02	-0.003200	2.31e-01	8.62e-01
Phase-I—Functionalization-of-compounds	83	8.77e-01	9.33e-01	0.02170	3.11e-03	0.021500	9.61e-01	7.35e-01
Cytokine-Signaling-in-Immune-system	606	3.34e-01	5.12e-01	0.02150	-2.04e-02	-0.006810	3.89e-01	7.74e-01
SARS-CoV-1-Infection	47	9.18e-01	9.53e-01	0.02050	9.18e-03	0.018300	9.13e-01	8.28e-01
PIP3-activates-AKT-signaling	257	7.69e-01	8.60e-01	0.01980	-1.97e-02	0.000921	5.85e-01	9.80e-01
TCF-dependent-signaling-in-response-to-WNT	164	9.38e-01	9.60e-01	0.01880	1.61e-02	-0.009710	7.21e-01	8.30e-01
Intracellular-signaling-by-second-messengers	295	8.83e-01	9.36e-01	0.01820	-8.14e-03	0.016300	8.10e-01	6.29e-01
Signaling-by-MET	66	9.70e-01	9.77e-01	0.01760	1.63e-02	-0.006530	8.19e-01	9.27e-01
Biological-oxidations	168	9.12e-01	9.51e-01	0.01570	-2.33e-03	0.015500	9.58e-01	7.29e-01
SUMOylation-of-DNA-damage-response-and-repair-proteins	74	9.27e-01	9.57e-01	0.01530	1.36e-02	0.007090	8.40e-01	9.16e-01
Mitochondrial-biogenesis	73	9.67e-01	9.75e-01	0.01310	5.41e-04	-0.013100	9.94e-01	8.47e-01
Phase-II—Conjugation-of-compounds	80	9.89e-01	9.92e-01	0.01220	7.40e-03	-0.009660	9.09e-01	8.81e-01
Suppression-of-phagosomal-maturation	12	9.98e-01	9.98e-01	0.01130	-5.90e-03	0.009610	9.72e-01	9.54e-01
Cellular-Senescence	124	9.54e-01	9.68e-01	0.00952	-3.77e-03	-0.008740	9.42e-01	8.66e-01
Regulation-of-HSF1-mediated-heat-shock-response	74	9.95e-01	9.96e-01	0.00905	-5.97e-03	0.006800	9.29e-01	9.19e-01
Generic-Transcription-Pathway	905	7.69e-01	8.60e-01	0.00861	-2.89e-03	-0.008110	8.82e-01	6.78e-01
Interferon-Signaling	152	9.66e-01	9.75e-01	0.00850	7.68e-04	0.008470	9.87e-01	8.57e-01
ESR-mediated-signaling	157	9.90e-01	9.92e-01	0.00839	6.62e-03	-0.005150	8.86e-01	9.11e-01
Transcription-of-the-HIV-genome	64	9.96e-01	9.96e-01	0.00803	6.68e-03	-0.004450	9.26e-01	9.51e-01
Immune-System	1704	6.99e-01	8.12e-01	0.00711	3.34e-03	0.006270	8.17e-01	6.64e-01
Post-translational-protein-modification	1263	8.72e-01	9.31e-01	0.00670	6.68e-03	-0.000508	6.88e-01	9.76e-01
tRNA-processing	113	9.91e-01	9.93e-01	0.00572	5.68e-03	-0.000713	9.17e-01	9.90e-01

---

Detailed Gene set reports

Viral-mRNA-Translation

Viral-mRNA-Translation

metric	value
setSize	73
pMANOVA	2.05e-33
p.adjustMANOVA	1.52e-30
s.dist	1.07
s.diab	0.701
s.PMX	-0.802
p.diab	3.15e-25
p.PMX	1.64e-32

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Dnajc3	-9188.0	-13392.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Grsf1	9214.0	-9055.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Peptide-chain-elongation

Peptide-chain-elongation

metric	value
setSize	73
pMANOVA	1.36e-32
p.adjustMANOVA	6.71e-30
s.dist	1.05
s.diab	0.699
s.PMX	-0.789
p.diab	4.63e-25
p.PMX	1.69e-31

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eef1a1	6403.0	-13665.0
Eef2	-8913.0	4813.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency

Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency

metric	value
setSize	85
pMANOVA	1.11e-34
p.adjustMANOVA	1.65e-31
s.dist	1.01
s.diab	0.665
s.PMX	-0.757
p.diab	2.47e-26
p.PMX	1.35e-33

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Asns	14974.0	-13140.0
Atf2	-6723.0	3300.0
Atf3	5940.0	-10511.0
Atf4	10850.0	-13249.0
Cebpb	15167.0	-15133.0
Cebpg	-7894.0	-8449.0
Ddit3	13910.0	-13026.0
Eif2ak4	12662.0	-12468.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Flt3l	-10231.0	11283.0
Gcn1l1	-8991.0	12087.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Impact	7475.0	-12025.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Trib3	13141.0	-7115.0
Uba52	4596.0	-6796.0

---

---

Eukaryotic-Translation-Elongation

Eukaryotic-Translation-Elongation

metric	value
setSize	77
pMANOVA	2.8e-31
p.adjustMANOVA	6.91e-29
s.dist	1
s.diab	0.665
s.PMX	-0.753
p.diab	5.05e-24
p.PMX	2.61e-30

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eef1a1	6403.0	-13665.0
Eef1a2	10648.0	-10014.0
Eef1b2	14272.0	-14363.0
Eef1d	-8373.0	5588.0
Eef1g	-8453.0	9394.0
Eef2	-8913.0	4813.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Formation-of-a-pool-of-free-40S-subunits

Formation-of-a-pool-of-free-40S-subunits

metric	value
setSize	85
pMANOVA	2.2e-32
p.adjustMANOVA	8.16e-30
s.dist	0.976
s.diab	0.653
s.PMX	-0.725
p.diab	2e-25
p.PMX	5.44e-31

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Eukaryotic-Translation-Termination

Eukaryotic-Translation-Termination

metric	value
setSize	77
pMANOVA	4.39e-29
p.adjustMANOVA	5.92e-27
s.dist	0.97
s.diab	0.646
s.PMX	-0.723
p.diab	9.58e-23
p.PMX	4.67e-28

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Apeh	-11381.0	10100.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
N6amt1	-5072.0	10569.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Trmt112	-11645.0	12227.0
Uba52	4596.0	-6796.0

---

---

Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex

Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex

metric	value
setSize	46
pMANOVA	2.88e-17
p.adjustMANOVA	1.71e-15
s.dist	0.963
s.diab	0.66
s.PMX	-0.701
p.diab	9.2e-15
p.PMX	1.88e-16

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305
Rpsa	15188	-13108

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

Selenocysteine-synthesis

Selenocysteine-synthesis

metric	value
setSize	76
pMANOVA	9.92e-27
p.adjustMANOVA	1.13e-24
s.dist	0.935
s.diab	0.624
s.PMX	-0.696
p.diab	4.92e-21
p.PMX	7.72e-26

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eefsec	-7997.0	11830.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pstk	-9537.0	9420.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Secisbp2	-9337.0	10086.0
Sephs2	-10506.0	11018.0
Sepsecs	-12324.0	11433.0
Uba52	4596.0	-6796.0

---

---

Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)

Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)

metric	value
setSize	79
pMANOVA	3.34e-27
p.adjustMANOVA	4.12e-25
s.dist	0.925
s.diab	0.617
s.PMX	-0.69
p.diab	2.42e-21
p.PMX	2.63e-26

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0
Upf1	-11946.0	12557.0

---

---

Phosphorylation-of-CD3-and-TCR-zeta-chains

Phosphorylation-of-CD3-and-TCR-zeta-chains

metric	value
setSize	17
pMANOVA	1.36e-06
p.adjustMANOVA	4.02e-05
s.dist	0.896
s.diab	-0.523
s.PMX	0.727
p.diab	0.000186
p.PMX	2.08e-07

Top 20 genes

Gene	diab	PMX
Ptprc	-12569	12780
H2-Eb1	-11506	12142
Csk	-11205	12433
H2-Aa	-11619	11020
Pag1	-9371	12012
Cd3d	-9851	9288
Lck	-8490	10472
Cd3g	-9324	8029
Cd247	-6082	11572
Cd3e	-8888	6762
H2-Ab1	-9278	6360
Ptpn22	-5781	6555
Cd4	-2373	10589
Trbc1	-351	11521
Trac	-164	8877

Click HERE to show all gene set members

All member genes

	diab	PMX
Cd247	-6082.0	11572
Cd3d	-9851.0	9288
Cd3e	-8888.0	6762
Cd3g	-9324.0	8029
Cd4	-2373.0	10589
Csk	-11205.0	12433
H2-Aa	-11619.0	11020
H2-Ab1	-9278.0	6360
H2-Eb1	-11506.0	12142
Lck	-8490.0	10472
Pag1	-9371.0	12012
Ptpn22	-5781.0	6555
Ptprc	-12569.0	12780
Ptprj	12888.0	141
Trac	-164.0	8877
Trbc1	-351.0	11521
Trbv15	876.5	5383

---

---

GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit

GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit

metric	value
setSize	96
pMANOVA	2.23e-31
p.adjustMANOVA	6.62e-29
s.dist	0.895
s.diab	0.578
s.PMX	-0.684
p.diab	1.14e-22
p.PMX	3.98e-31

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

PD-1-signaling

PD-1-signaling

metric	value
setSize	17
pMANOVA	2.65e-06
p.adjustMANOVA	7.41e-05
s.dist	0.895
s.diab	-0.555
s.PMX	0.702
p.diab	7.37e-05
p.PMX	5.3e-07

Top 20 genes

Gene	diab	PMX
H2-Eb1	-11506	12142
Csk	-11205	12433
H2-Aa	-11619	11020
Ptpn6	-8957	10520
Cd3d	-9851	9288
Lck	-8490	10472
Cd3g	-9324	8029
Cd247	-6082	11572
Cd3e	-8888	6762
H2-Ab1	-9278	6360
Cd4	-2373	10589
Ptpn11	-3808	6242
Pdcd1	-1680	8677
Trbc1	-351	11521
Trac	-164	8877
Cd274	-7978	120

Click HERE to show all gene set members

All member genes

	diab	PMX
Cd247	-6082.0	11572
Cd274	-7978.0	120
Cd3d	-9851.0	9288
Cd3e	-8888.0	6762
Cd3g	-9324.0	8029
Cd4	-2373.0	10589
Csk	-11205.0	12433
H2-Aa	-11619.0	11020
H2-Ab1	-9278.0	6360
H2-Eb1	-11506.0	12142
Lck	-8490.0	10472
Pdcd1	-1680.0	8677
Ptpn11	-3808.0	6242
Ptpn6	-8957.0	10520
Trac	-164.0	8877
Trbc1	-351.0	11521
Trbv15	876.5	5383

---

---

Translocation-of-ZAP-70-to-Immunological-synapse

Translocation-of-ZAP-70-to-Immunological-synapse

metric	value
setSize	14
pMANOVA	2.05e-05
p.adjustMANOVA	0.000338
s.dist	0.892
s.diab	-0.535
s.PMX	0.714
p.diab	0.000527
p.PMX	3.69e-06

Top 20 genes

Gene	diab	PMX
H2-Eb1	-11506	12142
H2-Aa	-11619	11020
Cd3d	-9851	9288
Lck	-8490	10472
Cd3g	-9324	8029
Cd247	-6082	11572
Cd3e	-8888	6762
H2-Ab1	-9278	6360
Ptpn22	-5781	6555
Zap70	-4347	7316
Cd4	-2373	10589
Trbc1	-351	11521
Trac	-164	8877

Click HERE to show all gene set members

All member genes

	diab	PMX
Cd247	-6082.0	11572
Cd3d	-9851.0	9288
Cd3e	-8888.0	6762
Cd3g	-9324.0	8029
Cd4	-2373.0	10589
H2-Aa	-11619.0	11020
H2-Ab1	-9278.0	6360
H2-Eb1	-11506.0	12142
Lck	-8490.0	10472
Ptpn22	-5781.0	6555
Trac	-164.0	8877
Trbc1	-351.0	11521
Trbv15	876.5	5383
Zap70	-4347.0	7316

---

---

L13a-mediated-translational-silencing-of-Ceruloplasmin-expression

L13a-mediated-translational-silencing-of-Ceruloplasmin-expression

metric	value
setSize	95
pMANOVA	4.56e-30
p.adjustMANOVA	9.66e-28
s.dist	0.883
s.diab	0.574
s.PMX	-0.671
p.diab	3.79e-22
p.PMX	1.08e-29

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Ribosomal-scanning-and-start-codon-recognition

Ribosomal-scanning-and-start-codon-recognition

metric	value
setSize	53
pMANOVA	1.26e-15
p.adjustMANOVA	6.9e-14
s.dist	0.841
s.diab	0.545
s.PMX	-0.641
p.diab	6.61e-12
p.PMX	6.6e-16

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305
Rpsa	15188	-13108

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Eif4a1	3248.0	-13189
Eif4a2	-10764.0	-7297
Eif4b	-10769.0	8501
Eif4e	-6639.0	-8178
Eif4g1	-7805.0	7417
Eif4h	9857.0	-5981
Eif5	11068.0	-12964
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

Cap-dependent-Translation-Initiation

Cap-dependent-Translation-Initiation

metric	value
setSize	103
pMANOVA	4.08e-29
p.adjustMANOVA	5.92e-27
s.dist	0.837
s.diab	0.551
s.PMX	-0.63
p.diab	4.15e-22
p.PMX	1.83e-28

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Eif4ebp1	15028	-14599
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2b1	11279.0	-2807.0
Eif2b2	-5526.0	8016.0
Eif2b3	-275.0	-7159.0
Eif2b4	-5228.0	6620.0
Eif2b5	9058.0	8598.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4ebp1	15028.0	-14599.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Eukaryotic-Translation-Initiation

Eukaryotic-Translation-Initiation

metric	value
setSize	103
pMANOVA	4.08e-29
p.adjustMANOVA	5.92e-27
s.dist	0.837
s.diab	0.551
s.PMX	-0.63
p.diab	4.15e-22
p.PMX	1.83e-28

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Eif4ebp1	15028	-14599
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2b1	11279.0	-2807.0
Eif2b2	-5526.0	8016.0
Eif2b3	-275.0	-7159.0
Eif2b4	-5228.0	6620.0
Eif2b5	9058.0	8598.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4ebp1	15028.0	-14599.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S

Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S

metric	value
setSize	54
pMANOVA	3.11e-15
p.adjustMANOVA	1.53e-13
s.dist	0.825
s.diab	0.541
s.PMX	-0.623
p.diab	6.13e-12
p.PMX	2.24e-15

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Eif4ebp1	15028	-14599
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Eif4a1	3248.0	-13189
Eif4a2	-10764.0	-7297
Eif4b	-10769.0	8501
Eif4e	-6639.0	-8178
Eif4ebp1	15028.0	-14599
Eif4g1	-7805.0	7417
Eif4h	9857.0	-5981
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Pabpc2	1803.5	5051
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

Gluconeogenesis

Gluconeogenesis

metric	value
setSize	30
pMANOVA	1.22e-08
p.adjustMANOVA	4.53e-07
s.dist	0.824
s.diab	0.6
s.PMX	-0.565
p.diab	1.25e-08
p.PMX	8.28e-08

Top 20 genes

Gene	diab	PMX
Aldoc	15389	-15147
Mdh1	15344	-15111
Eno1	15346	-14918
Aldob	15112	-15035
Pck1	15049	-15032
Got1	15126	-14433
Fbp2	15221	-14331
Slc37a4	14589	-14261
Pgk1	14769	-14051
Gpi1	14553	-14068
Fbp1	14971	-13560
Pgam1	14351	-13615
Mdh2	14022	-13258
Got2	14120	-12201
Eno2	11792	-13834
Eno3	12251	-12638
Slc37a1	13012	-11840
Slc25a12	15159	-10019
Slc25a11	12566	-9400
Tpi1	12212	-9334

Click HERE to show all gene set members

All member genes

	diab	PMX
Aldoart2	-2897.5	617.5
Aldob	15112.0	-15035.0
Aldoc	15389.0	-15147.0
Eno1	15346.0	-14918.0
Eno2	11792.0	-13834.0
Eno3	12251.0	-12638.0
Fbp1	14971.0	-13560.0
Fbp2	15221.0	-14331.0
G6pc2	6368.0	-5830.0
G6pc3	-3265.0	-265.0
Got1	15126.0	-14433.0
Got2	14120.0	-12201.0
Gpi1	14553.0	-14068.0
Mdh1	15344.0	-15111.0
Mdh2	14022.0	-13258.0
Pck1	15049.0	-15032.0
Pck2	12500.0	2592.0
Pcx	-10992.0	8150.0
Pgam1	14351.0	-13615.0
Pgam2	10491.0	12436.0
Pgk1	14769.0	-14051.0
Slc25a1	7798.0	-8481.0
Slc25a10	4794.0	-10546.0
Slc25a11	12566.0	-9400.0
Slc25a12	15159.0	-10019.0
Slc25a13	-8801.0	-10830.0
Slc37a1	13012.0	-11840.0
Slc37a2	-8352.0	7658.0
Slc37a4	14589.0	-14261.0
Tpi1	12212.0	-9334.0

---

---

Translation-initiation-complex-formation

Translation-initiation-complex-formation

metric	value
setSize	53
pMANOVA	1.24e-14
p.adjustMANOVA	5.72e-13
s.dist	0.815
s.diab	0.532
s.PMX	-0.617
p.diab	1.96e-11
p.PMX	7.69e-15

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305
Rpsa	15188	-13108

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Eif4a1	3248.0	-13189
Eif4a2	-10764.0	-7297
Eif4b	-10769.0	8501
Eif4e	-6639.0	-8178
Eif4g1	-7805.0	7417
Eif4h	9857.0	-5981
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Pabpc2	1803.5	5051
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

Acetylcholine-regulates-insulin-secretion

Acetylcholine-regulates-insulin-secretion

metric	value
setSize	10
pMANOVA	0.0034
p.adjustMANOVA	0.0203
s.dist	0.791
s.diab	-0.52
s.PMX	0.596
p.diab	0.0044
p.PMX	0.00109

Top 20 genes

Gene	diab	PMX
Marcks	-12211	12959
Plcb2	-11254	12407
Gna14	-11102	12283
Plcb3	-10411	12326
Prkca	-11577	11021
Gna15	-10426	9120
Chrm3	-3741	10213
Plcb1	-7289	1115

Click HERE to show all gene set members

All member genes

	diab	PMX
Chrm3	-3741	10213
Gna11	13209	-163
Gna14	-11102	12283
Gna15	-10426	9120
Gnaq	4627	-7966
Marcks	-12211	12959
Plcb1	-7289	1115
Plcb2	-11254	12407
Plcb3	-10411	12326
Prkca	-11577	11021

---

---

SRP-dependent-cotranslational-protein-targeting-to-membrane

SRP-dependent-cotranslational-protein-targeting-to-membrane

metric	value
setSize	96
pMANOVA	6.92e-26
p.adjustMANOVA	7.33e-24
s.dist	0.786
s.diab	0.465
s.PMX	-0.633
p.diab	3.24e-15
p.PMX	6.67e-27

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Ddost	-11311.0	11142.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpn1	-12234.0	10781.0
Rpn2	-8531.0	4240.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sec11a	-10050.0	-13192.0
Sec11c	6317.0	-11728.0
Sec61a1	-10632.0	9529.0
Sec61a2	2273.0	-12284.0
Sec61b	-6804.0	8046.0
Sec61g	2842.0	-5782.0
Spcs1	-9784.0	-9337.0
Spcs2	-11309.0	6712.0
Spcs3	6719.0	-10661.0
Srp14	10201.0	-11271.0
Srp19	-8639.0	-9543.0
Srp54a	-4764.0	766.0
Srp68	4472.0	-4510.0
Srp72	8797.0	-11367.0
Srp9	-1833.0	-7812.0
Srpr	10750.0	-13353.0
Srprb	3421.0	2100.0
Ssr1	-11725.0	10337.0
Ssr2	-8791.0	-2977.0
Ssr3	-933.0	-13076.0
Ssr4	11159.0	-13592.0
Tram1	-12409.0	9369.0
Uba52	4596.0	-6796.0

---

---

Response-of-EIF2AK1-(HRI)-to-heme-deficiency

Response-of-EIF2AK1-(HRI)-to-heme-deficiency

metric	value
setSize	15
pMANOVA	0.000272
p.adjustMANOVA	0.00265
s.dist	0.759
s.diab	0.466
s.PMX	-0.599
p.diab	0.00176
p.PMX	5.85e-05

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Ppp1r15a	14992	-14845
Atf5	15204	-14291
Asns	14974	-13140
Ddit3	13910	-13026
Eif2s2	11201	-14019
Atf4	10850	-13249
Chac1	9497	-11449
Trib3	13141	-7115
Atf3	5940	-10511
Eif2s3x	4982	-5754
Eif2s1	3692	-6086
Eif2ak1	3385	-5086

Click HERE to show all gene set members

All member genes

	diab	PMX
Asns	14974	-13140
Atf3	5940	-10511
Atf4	10850	-13249
Atf5	15204	-14291
Cebpb	15167	-15133
Cebpg	-7894	-8449
Chac1	9497	-11449
Ddit3	13910	-13026
Eif2ak1	3385	-5086
Eif2s1	3692	-6086
Eif2s2	11201	-14019
Eif2s3x	4982	-5754
Grb10	-10947	9629
Ppp1r15a	14992	-14845
Trib3	13141	-7115

---

---

Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)

Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)

metric	value
setSize	99
pMANOVA	5.66e-23
p.adjustMANOVA	4.66e-21
s.dist	0.758
s.diab	0.507
s.PMX	-0.564
p.diab	2.59e-18
p.PMX	2.75e-22

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Casc3	-213.0	8374.0
Dcp1a	-6339.0	-22.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Pnrc2	-2276.0	-10147.0
Ppp2ca	2443.0	326.0
Ppp2r1a	11507.0	3755.0
Ppp2r2a	-1142.0	-9444.0
Rbm8a2	-485.5	-1222.5
Rnps1	11263.0	-12563.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Smg1	8862.0	-12241.0
Smg5	-7764.0	7622.0
Smg6	7235.0	-5765.0
Smg7	-83.0	2903.0
Smg8	4295.0	2512.0
Smg9	-8087.0	9030.0
Uba52	4596.0	-6796.0
Upf1	-11946.0	12557.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0

---

---

Nonsense-Mediated-Decay-(NMD)

Nonsense-Mediated-Decay-(NMD)

metric	value
setSize	99
pMANOVA	5.66e-23
p.adjustMANOVA	4.66e-21
s.dist	0.758
s.diab	0.507
s.PMX	-0.564
p.diab	2.59e-18
p.PMX	2.75e-22

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Casc3	-213.0	8374.0
Dcp1a	-6339.0	-22.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Pnrc2	-2276.0	-10147.0
Ppp2ca	2443.0	326.0
Ppp2r1a	11507.0	3755.0
Ppp2r2a	-1142.0	-9444.0
Rbm8a2	-485.5	-1222.5
Rnps1	11263.0	-12563.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Smg1	8862.0	-12241.0
Smg5	-7764.0	7622.0
Smg6	7235.0	-5765.0
Smg7	-83.0	2903.0
Smg8	4295.0	2512.0
Smg9	-8087.0	9030.0
Uba52	4596.0	-6796.0
Upf1	-11946.0	12557.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0

---

---

Organic-cation/anion/zwitterion-transport

Organic-cation/anion/zwitterion-transport

metric	value
setSize	12
pMANOVA	0.00199
p.adjustMANOVA	0.0129
s.dist	0.757
s.diab	-0.502
s.PMX	0.567
p.diab	0.00261
p.PMX	0.000675

Top 20 genes

Gene	diab	PMX
Slc22a12	-12706	12935
Slc22a18	-12514	12484
Slc22a7	-12175	11480
Slc22a4	-11447	12036
Slc22a2	-12013	9585
Slc22a8	-10810	8065
Slc22a6	-10040	7803
Slc22a5	-8530	5749
Runx1	-8565	3304

Click HERE to show all gene set members

All member genes

	diab	PMX
Runx1	-8565	3304
Slc22a1	5036	4679
Slc22a12	-12706	12935
Slc22a15	11185	-9803
Slc22a18	-12514	12484
Slc22a2	-12013	9585
Slc22a3	13467	4674
Slc22a4	-11447	12036
Slc22a5	-8530	5749
Slc22a6	-10040	7803
Slc22a7	-12175	11480
Slc22a8	-10810	8065

---

---

Complex-I-biogenesis

Complex-I-biogenesis

metric	value
setSize	54
pMANOVA	7.15e-13
p.adjustMANOVA	3.12e-11
s.dist	0.757
s.diab	0.5
s.PMX	-0.568
p.diab	1.98e-10
p.PMX	5.21e-13

Top 20 genes

Gene	diab	PMX
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Ndufb11	14492	-14964
Ndufa9	14469	-14794
Ndufb5	14481	-14745
Ndufs6	14367	-14846
Ndufa11	14920	-14266
Ndufa12	14903	-14234
Ndufb10	14262	-14459
Ndufs3	14315	-14178
Ndufa2	13627	-14858
Ndufc1	14230	-14172
Ndufa13	14115	-14226
Ndufs4	14110	-14049
Ndufs5	13994	-14136
Ndufs2	14590	-13546

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100	-9605
Ecsit	-9099	9725
mt-Nd1	13965	-13142
mt-Nd2	13232	-13777
mt-Nd3	5043	-3048
mt-Nd4	9342	-12167
mt-Nd5	13692	-13085
mt-Nd6	14568	-9103
Ndufa1	6937	-8412
Ndufa10	11110	-8885
Ndufa11	14920	-14266
Ndufa12	14903	-14234
Ndufa13	14115	-14226
Ndufa2	13627	-14858
Ndufa3	14864	-14832
Ndufa5	15074	-14984
Ndufa6	14999	-14781
Ndufa7	15178	-15058
Ndufa8	13665	-11997
Ndufa9	14469	-14794
Ndufab1	3106	-9458
Ndufaf1	-11416	10941
Ndufaf2	7440	-8823
Ndufaf3	367	-9795
Ndufaf4	-10599	6962
Ndufaf5	11575	-3621
Ndufaf6	333	-11082
Ndufaf7	9013	1113
Ndufb10	14262	-14459
Ndufb11	14492	-14964
Ndufb2	-4388	-8058
Ndufb3	12259	-14461
Ndufb4	9233	-12329
Ndufb5	14481	-14745
Ndufb6	14565	-13471
Ndufb7	13625	-13723
Ndufb9	15350	-14839
Ndufc1	14230	-14172
Ndufc2	13402	-13866
Ndufs1	7192	-12095
Ndufs2	14590	-13546
Ndufs3	14315	-14178
Ndufs4	14110	-14049
Ndufs5	13994	-14136
Ndufs6	14367	-14846
Ndufs7	11801	-14074
Ndufs8	12503	-14256
Ndufv1	7781	-368
Ndufv2	15041	-14992
Ndufv3	8348	4422
Nubpl	-8841	6873
Timmdc1	-7729	8038
Tmem126b	-11814	6995
Tmem186	-10081	10176

---

---

Selenoamino-acid-metabolism

Selenoamino-acid-metabolism

metric	value
setSize	91
pMANOVA	3.37e-21
p.adjustMANOVA	2.63e-19
s.dist	0.756
s.diab	0.496
s.PMX	-0.57
p.diab	2.52e-16
p.PMX	5.2e-21

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcy	-6297.0	-13572.0
Aimp1	10685.0	-10801.0
Aimp2	3346.0	9731.0
Cbs	-12747.0	12807.0
Cth	13940.0	-15012.0
Eefsec	-7997.0	11830.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnmt	-4555.0	5322.0
Gsr	3160.0	8021.0
Hnmt	-6205.0	-4283.0
Inmt	-12551.0	12151.0
Mat1a	4223.0	-12815.0
Nnmt	11136.0	-12817.0
Papss1	-8777.0	11499.0
Papss2	12971.0	-12114.0
Pstk	-9537.0	9420.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Scly	-9905.0	9810.0
Secisbp2	-9337.0	10086.0
Sephs2	-10506.0	11018.0
Sepsecs	-12324.0	11433.0
Txnrd1	-10298.0	11671.0
Uba52	4596.0	-6796.0

---

---

Synthesis-of-PE

Synthesis-of-PE

metric	value
setSize	12
pMANOVA	0.00252
p.adjustMANOVA	0.016
s.dist	0.748
s.diab	0.528
s.PMX	-0.53
p.diab	0.00152
p.PMX	0.00148

Top 20 genes

Gene	diab	PMX
Etnk1	15231	-14942
Chkb	15237	-14512
Etnppl	14345	-14400
Lpin1	13638	-14073
Lpin2	12674	-14612
Cept1	11589	-14060
Etnk2	9476	-14783
Lpin3	14358	-8350
Phospho1	9846	-10338
Chka	10827	-6725

Click HERE to show all gene set members

All member genes

	diab	PMX
AC149090.1	-9700	11545
Cept1	11589	-14060
Chka	10827	-6725
Chkb	15237	-14512
Etnk1	15231	-14942
Etnk2	9476	-14783
Etnppl	14345	-14400
Lpin1	13638	-14073
Lpin2	12674	-14612
Lpin3	14358	-8350
Pcyt2	-12540	12932
Phospho1	9846	-10338

---

---

Citric-acid-cycle-(TCA-cycle)

Citric-acid-cycle-(TCA-cycle)

metric	value
setSize	22
pMANOVA	2.15e-05
p.adjustMANOVA	0.000347
s.dist	0.738
s.diab	0.501
s.PMX	-0.542
p.diab	4.71e-05
p.PMX	1.06e-05

Top 20 genes

Gene	diab	PMX
Nnt	15395	-15153
Sdhd	15189	-14923
Aco2	15080	-14219
Sdhb	14750	-14069
Fh1	14053	-14546
Mdh2	14022	-13258
Suclg1	12169	-12783
Cs	14592	-10223
Idh3a	12635	-11295
Idh3b	11502	-11793
Dlst	10927	-8985
Ogdh	12207	-6438
Dld	5477	-13041
Idh3g	4738	-13228
Me3	10234	-4629
Sdha	7583	-6150
Idh2	4708	-8898
Sucla2	275	-12058

Click HERE to show all gene set members

All member genes

	diab	PMX
Aco2	15080	-14219
Cs	14592	-10223
Dld	5477	-13041
Dlst	10927	-8985
Fahd1	-11442	10570
Fh1	14053	-14546
Idh2	4708	-8898
Idh3a	12635	-11295
Idh3b	11502	-11793
Idh3g	4738	-13228
Mdh2	14022	-13258
Me2	13676	5847
Me3	10234	-4629
Nnt	15395	-15153
Ogdh	12207	-6438
Sdha	7583	-6150
Sdhb	14750	-14069
Sdhc	-6156	-7176
Sdhd	15189	-14923
Sucla2	275	-12058
Suclg1	12169	-12783
Suclg2	-7679	5102

---

---

Cellular-response-to-starvation

Cellular-response-to-starvation

metric	value
setSize	138
pMANOVA	2.09e-29
p.adjustMANOVA	3.87e-27
s.dist	0.734
s.diab	0.517
s.PMX	-0.521
p.diab	8.43e-26
p.PMX	3.42e-26

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Atp6v0e	14931	-14952
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Sesn1	14846	-14730
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843

Click HERE to show all gene set members

All member genes

	diab	PMX
Asns	14974.0	-13140.0
Atf2	-6723.0	3300.0
Atf3	5940.0	-10511.0
Atf4	10850.0	-13249.0
Atp6v0b	4840.0	2125.0
Atp6v0c	3151.0	-10611.0
Atp6v0d1	203.0	1912.0
Atp6v0d2	15150.0	-3904.0
Atp6v0e	14931.0	-14952.0
Atp6v0e2	7872.0	6422.0
Atp6v1a	10227.0	-7433.0
Atp6v1b1	13172.0	12006.0
Atp6v1b2	-7304.0	5553.0
Atp6v1c1	12161.0	-10561.0
Atp6v1c2	14305.0	9508.0
Atp6v1d	12172.0	-14697.0
Atp6v1e1	13351.0	-11187.0
Atp6v1f	14121.0	-13473.0
Atp6v1g1	15089.0	-12782.0
Atp6v1g2	-3055.0	4701.0
Atp6v1g3	14162.0	-9021.0
Atp6v1h	9566.0	-8530.0
BC048403	8126.0	-4500.0
Cebpb	15167.0	-15133.0
Cebpg	-7894.0	-8449.0
Ddit3	13910.0	-13026.0
Depdc5	10603.0	-12516.0
Eif2ak4	12662.0	-12468.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Flcn	8427.0	2620.0
Flt3l	-10231.0	11283.0
Fnip1	5376.0	-14121.0
Fnip2	6241.0	-11575.0
Gatsl2	10871.0	-9194.0
Gatsl3	-1475.0	8414.0
Gcn1l1	-8991.0	12087.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Impact	7475.0	-12025.0
Itfg2	10888.0	-7999.0
Kptn	-3141.0	-2510.0
Lamtor1	8753.0	5215.0
Lamtor2	-7753.0	1820.0
Lamtor3	11338.0	-7218.0
Lamtor4	5699.0	-11078.0
Lamtor5	13418.0	-13042.0
Mios	6357.0	-10601.0
Mlst8	-8191.0	9545.0
Mtor	-12191.0	-146.0
Nprl2	-3481.0	7578.0
Nprl3	7260.0	4129.0
Rheb	-8480.0	2846.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rptor	4891.0	6876.0
Rraga	-11375.0	9072.0
Rragb	10214.0	2103.0
Rragc	10681.0	-445.0
Rragd	15304.0	-13993.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Sesn1	14846.0	-14730.0
Sesn2	2837.0	-13400.0
Sh3bp4	14556.0	-12878.0
Slc38a9	-7282.0	6109.0
Szt2	-5351.0	10104.0
Tcirg1	-10070.0	11128.0
Trib3	13141.0	-7115.0
Uba52	4596.0	-6796.0
Wdr24	-11111.0	12295.0
Wdr59	-5055.0	-6197.0

---

---

Defective-GALNT12-causes-colorectal-cancer-1-(CRCS1)

Defective-GALNT12-causes-colorectal-cancer-1-(CRCS1)

metric	value
setSize	12
pMANOVA	0.00135
p.adjustMANOVA	0.00966
s.dist	0.729
s.diab	0.606
s.PMX	-0.405
p.diab	0.000278
p.PMX	0.015

Top 20 genes

Gene	diab	PMX
Muc20	15289	-14812
Muc1	14973	-14580
Muc3a	14817	-14389
Muc13	14420	-14311
Muc4	10779	-8646
Muc5b	8058	-8653
Galnt12	13718	-4632
Muc15	9274	-5006
Muc3	2925	-5276
Muc5ac	8150	-362

Click HERE to show all gene set members

All member genes

	diab	PMX
Galnt12	13718.0	-4632
Muc1	14973.0	-14580
Muc13	14420.0	-14311
Muc15	9274.0	-5006
Muc16	3856.0	6350
Muc20	15289.0	-14812
Muc3	2925.0	-5276
Muc3a	14817.0	-14389
Muc4	10779.0	-8646
Muc5ac	8150.0	-362
Muc5b	8058.0	-8653
Muc6	1803.5	3045

---

---

STING-mediated-induction-of-host-immune-responses

STING-mediated-induction-of-host-immune-responses

metric	value
setSize	12
pMANOVA	0.00331
p.adjustMANOVA	0.02
s.dist	0.718
s.diab	-0.459
s.PMX	0.552
p.diab	0.00594
p.PMX	0.000918

Top 20 genes

Gene	diab	PMX
Stat6	-12160	12241
Irf3	-11590	11099
Prkdc	-10438	11762
Gm42641	-8899	11701
Nlrc3	-8143	11679
Ddx41	-9349	8319
Mre11a	-5960	7726
Trim21	-9603	210

Click HERE to show all gene set members

All member genes

	diab	PMX
Ddx41	-9349	8319
Dtx4	13151	11036
Gm42641	-8899	11701
Irf3	-11590	11099
Mre11a	-5960	7726
Nlrc3	-8143	11679
Prkdc	-10438	11762
Stat6	-12160	12241
Tbk1	-7135	-10900
Trim21	-9603	210
Xrcc5	2971	-409
Xrcc6	5331	6127

---

---

CD22-mediated-BCR-regulation

CD22-mediated-BCR-regulation

metric	value
setSize	17
pMANOVA	0.000316
p.adjustMANOVA	0.00298
s.dist	0.712
s.diab	-0.555
s.PMX	0.447
p.diab	7.52e-05
p.PMX	0.0014

Top 20 genes

Gene	diab	PMX
Ighd	-11252.0	12232.0
Igkc	-12203.0	11173.0
Cd79b	-10852.0	12150.0
Cd22	-11312.0	11195.0
Ighm	-9802.0	12152.0
Igkv1-135	-9391.0	12146.0
Cd79a	-11203.0	8822.0
Ptpn6	-8957.0	10520.0
Igkv17-127	-10984.0	6315.0
Ighv5-4	-8748.0	6914.0
Ighv9-1	-5234.0	4881.0
Ighv3-1	-3456.5	2317.5
Igkv14-130	-3167.5	2317.5
Lyn	-7639.0	6.0

Click HERE to show all gene set members

All member genes

	diab	PMX
Cd22	-11312.0	11195.0
Cd79a	-11203.0	8822.0
Cd79b	-10852.0	12150.0
Ighd	-11252.0	12232.0
Ighm	-9802.0	12152.0
Ighv14-1	-4909.0	-6534.0
Ighv3-1	-3456.5	2317.5
Ighv5-4	-8748.0	6914.0
Ighv9-1	-5234.0	4881.0
Igkc	-12203.0	11173.0
Igkv1-135	-9391.0	12146.0
Igkv14-130	-3167.5	2317.5
Igkv17-127	-10984.0	6315.0
Igkv2-137	6752.0	-10319.0
Igll1	11837.0	-7314.0
Lyn	-7639.0	6.0
Ptpn6	-8957.0	10520.0

---

---

Influenza-Viral-RNA-Transcription-and-Replication

Influenza-Viral-RNA-Transcription-and-Replication

metric	value
setSize	118
pMANOVA	8.5e-24
p.adjustMANOVA	8.4e-22
s.dist	0.711
s.diab	0.489
s.PMX	-0.516
p.diab	4.21e-20
p.PMX	3.11e-22

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Dnajc3	-9188.0	-13392.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Grsf1	9214.0	-9055.0
Gtf2f1	10842.0	-11838.0
Gtf2f2	11210.0	-13043.0
Hsp90aa1	-12505.0	4614.0
Ipo5	11718.0	-12610.0
Ndc1	13238.0	-12109.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Parp1	-4209.0	11584.0
Polr2a	5917.0	6827.0
Polr2b	-9995.0	7496.0
Polr2c	-2600.0	9289.0
Polr2d	-4100.0	39.0
Polr2e	11726.0	-9159.0
Polr2f	11374.0	-6543.0
Polr2g	11118.0	-13257.0
Polr2h	224.0	-7426.0
Polr2i	13554.0	-12640.0
Polr2j	9902.0	-6099.0
Polr2k	7520.0	-11503.0
Polr2l	6213.0	4463.0
Pom121	9659.0	-12785.0
Rae1	-2818.0	7959.0
Ranbp2	-1884.0	-9227.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Tpr	-7568.0	-3358.0
Uba52	4596.0	-6796.0

---

---

Mitochondrial-tRNA-aminoacylation

Mitochondrial-tRNA-aminoacylation

metric	value
setSize	18
pMANOVA	0.000313
p.adjustMANOVA	0.00297
s.dist	0.705
s.diab	-0.526
s.PMX	0.468
p.diab	0.00011
p.PMX	0.000579

Top 20 genes

Gene	diab	PMX
Ears2	-11491	12252
Rars2	-10416	12229
Cars2	-9513	11616
Mars2	-10146	10260
Yars2	-10916	8204
Nars2	-7825	11278
Tars2	-6710	11620
Wars2	-7250	9357
Hars2	-10552	4750
Iars2	-8173	4030
Ppa2	-10837	1791
Fars2	-6772	2553
Vars2	-5375	1750
Dars2	-10385	364

Click HERE to show all gene set members

All member genes

	diab	PMX
Aars2	3152	6044
Cars2	-9513	11616
Dars2	-10385	364
Ears2	-11491	12252
Fars2	-6772	2553
Hars2	-10552	4750
Iars2	-8173	4030
Lars2	2973	-11810
Mars2	-10146	10260
Nars2	-7825	11278
Pars2	3022	-5996
Ppa2	-10837	1791
Rars2	-10416	12229
Sars2	7342	9250
Tars2	-6710	11620
Vars2	-5375	1750
Wars2	-7250	9357
Yars2	-10916	8204

---

---

Alpha-protein-kinase-1-signaling-pathway

Alpha-protein-kinase-1-signaling-pathway

metric	value
setSize	10
pMANOVA	0.00873
p.adjustMANOVA	0.0427
s.dist	0.703
s.diab	0.427
s.PMX	-0.559
p.diab	0.0193
p.PMX	0.0022

Top 20 genes

Gene	diab	PMX
Rps27a	13894	-14715
Traf6	13741	-14203
Tab2	12547	-13610
Tifa	13520	-12178
Tab3	12461	-13030
Map3k7	10607	-11166
Uba52	4596	-6796

Click HERE to show all gene set members

All member genes

	diab	PMX
Alpk1	-5076	-4760
Map3k7	10607	-11166
Rps27a	13894	-14715
Tab1	335	9052
Tab2	12547	-13610
Tab3	12461	-13030
Tifa	13520	-12178
Traf6	13741	-14203
Uba52	4596	-6796
Ubb	-3411	-7959

---

---

Glutamate-and-glutamine-metabolism

Glutamate-and-glutamine-metabolism

metric	value
setSize	12
pMANOVA	0.0049
p.adjustMANOVA	0.0272
s.dist	0.7
s.diab	0.463
s.PMX	-0.525
p.diab	0.00549
p.PMX	0.00165

Top 20 genes

Gene	diab	PMX
Glud1	15380	-15127
Glul	14333	-14998
Oat	14211	-14408
Gls	13744	-14134
Got2	14120	-12201
Pycr2	14050	-10135
Aldh18a1	12016	-9762

Click HERE to show all gene set members

All member genes

	diab	PMX
Aldh18a1	12016	-9762
Gls	13744	-14134
Gls2	5942	60
Glud1	15380	-15127
Glul	14333	-14998
Got2	14120	-12201
Oat	14211	-14408
Pycr1	-4157	-4517
Pycr2	14050	-10135
Pycrl	-7439	-4811
Rimkla	11540	3444
Rimklb	-9845	-4853

---

---

Interleukin-2-signaling

Interleukin-2-signaling

metric	value
setSize	11
pMANOVA	0.00899
p.adjustMANOVA	0.0437
s.dist	0.687
s.diab	-0.518
s.PMX	0.451
p.diab	0.00294
p.PMX	0.00961

Top 20 genes

Gene	diab	PMX
Ptk2b	-11310	12917
Syk	-11535	11301
Lck	-8490	10472
Il2rb	-7155	12371
Jak1	-8327	10605
Shc1	-8826	9471
Il2ra	-7559	7699
Stat5a	-10619	4210

Click HERE to show all gene set members

All member genes

	diab	PMX
Il2	2709.5	-2670
Il2ra	-7559.0	7699
Il2rb	-7155.0	12371
Jak1	-8327.0	10605
Jak3	12162.0	-9722
Lck	-8490.0	10472
Ptk2b	-11310.0	12917
Shc1	-8826.0	9471
Stat5a	-10619.0	4210
Stat5b	-6896.0	-8519
Syk	-11535.0	11301

---

---

Respiratory-electron-transport

Respiratory-electron-transport

metric	value
setSize	99
pMANOVA	3.24e-19
p.adjustMANOVA	2.19e-17
s.dist	0.681
s.diab	0.43
s.PMX	-0.527
p.diab	1.31e-13
p.PMX	1.07e-19

Top 20 genes

Gene	diab	PMX
Uqcrb	15145	-15118
Uqcrh	15179	-15073
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Cox6b1	15253	-14902
Cox6c	15087	-15036
Sdhd	15189	-14923
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Cox5a	15090	-14747
Uqcrq	15160	-14637
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Cox7c	14740	-14896
Uqcr10	14874	-14710
Ndufb11	14492	-14964
Ndufa9	14469	-14794
Ndufb5	14481	-14745
Ndufs6	14367	-14846
Ndufa11	14920	-14266

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100.0	-9605.0
Coq10a	6677.0	7304.0
Coq10b	-10247.0	-10904.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Cyc1	13836.0	-13962.0
Cycs	8402.0	-13138.0
Ecsit	-9099.0	9725.0
Etfa	-9804.0	-7984.0
Etfb	11075.0	-11149.0
Etfdh	-1913.0	-8426.0
Gm11273	8317.0	-6691.0
Lrpprc	12946.0	-11138.0
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Ndufa1	6937.0	-8412.0
Ndufa10	11110.0	-8885.0
Ndufa11	14920.0	-14266.0
Ndufa12	14903.0	-14234.0
Ndufa13	14115.0	-14226.0
Ndufa2	13627.0	-14858.0
Ndufa3	14864.0	-14832.0
Ndufa4	9874.0	-14669.0
Ndufa5	15074.0	-14984.0
Ndufa6	14999.0	-14781.0
Ndufa7	15178.0	-15058.0
Ndufa8	13665.0	-11997.0
Ndufa9	14469.0	-14794.0
Ndufab1	3106.0	-9458.0
Ndufaf1	-11416.0	10941.0
Ndufaf2	7440.0	-8823.0
Ndufaf3	367.0	-9795.0
Ndufaf4	-10599.0	6962.0
Ndufaf5	11575.0	-3621.0
Ndufaf6	333.0	-11082.0
Ndufaf7	9013.0	1113.0
Ndufb10	14262.0	-14459.0
Ndufb11	14492.0	-14964.0
Ndufb2	-4388.0	-8058.0
Ndufb3	12259.0	-14461.0
Ndufb4	9233.0	-12329.0
Ndufb5	14481.0	-14745.0
Ndufb6	14565.0	-13471.0
Ndufb7	13625.0	-13723.0
Ndufb9	15350.0	-14839.0
Ndufc1	14230.0	-14172.0
Ndufc2	13402.0	-13866.0
Ndufs1	7192.0	-12095.0
Ndufs2	14590.0	-13546.0
Ndufs3	14315.0	-14178.0
Ndufs4	14110.0	-14049.0
Ndufs5	13994.0	-14136.0
Ndufs6	14367.0	-14846.0
Ndufs7	11801.0	-14074.0
Ndufs8	12503.0	-14256.0
Ndufv1	7781.0	-368.0
Ndufv2	15041.0	-14992.0
Ndufv3	8348.0	4422.0
Nubpl	-8841.0	6873.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sdha	7583.0	-6150.0
Sdhb	14750.0	-14069.0
Sdhc	-6156.0	-7176.0
Sdhd	15189.0	-14923.0
Surf1	10929.0	-8571.0
Taco1	-5127.0	3445.0
Timmdc1	-7729.0	8038.0
Tmem126b	-11814.0	6995.0
Tmem186	-10081.0	10176.0
Trap1	-11794.0	8106.0
Uqcr10	14874.0	-14710.0
Uqcr11	13121.0	-13943.0
Uqcrb	15145.0	-15118.0
Uqcrc1	12486.0	-6849.0
Uqcrc2	12361.0	-13694.0
Uqcrfs1	11242.0	-12436.0
Uqcrh	15179.0	-15073.0
Uqcrq	15160.0	-14637.0

---

---

IRF3-mediated-induction-of-type-I-IFN

IRF3-mediated-induction-of-type-I-IFN

metric	value
setSize	10
pMANOVA	0.00915
p.adjustMANOVA	0.0442
s.dist	0.675
s.diab	-0.377
s.PMX	0.559
p.diab	0.0389
p.PMX	0.00219

Top 20 genes

Gene	diab	PMX
Irf3	-11590	11099
Prkdc	-10438	11762
Gm42641	-8899	11701
Nlrc3	-8143	11679
Ddx41	-9349	8319
Mre11a	-5960	7726

Click HERE to show all gene set members

All member genes

	diab	PMX
Ddx41	-9349	8319
Dtx4	13151	11036
Gm42641	-8899	11701
Irf3	-11590	11099
Mre11a	-5960	7726
Nlrc3	-8143	11679
Prkdc	-10438	11762
Tbk1	-7135	-10900
Xrcc5	2971	-409
Xrcc6	5331	6127

---

---

Regulation-of-KIT-signaling

Regulation-of-KIT-signaling

metric	value
setSize	16
pMANOVA	0.00106
p.adjustMANOVA	0.00788
s.dist	0.671
s.diab	-0.412
s.PMX	0.53
p.diab	0.00428
p.PMX	0.000242

Top 20 genes

Gene	diab	PMX
Cbl	-12477	12607
Prkca	-11577	11021
Sh2b2	-10921	11472
Sos1	-11977	9665
Ptpn6	-8957	10520
Lck	-8490	10472
Fyn	-6985	9856
Kitl	-8505	7968
Socs6	-8798	4670
Socs1	-79	9008
Lyn	-7639	6

Click HERE to show all gene set members

All member genes

	diab	PMX
Cbl	-12477	12607
Fyn	-6985	9856
Grb2	8972	3406
Kit	11184	7338
Kitl	-8505	7968
Lck	-8490	10472
Lyn	-7639	6
Prkca	-11577	11021
Ptpn6	-8957	10520
Sh2b2	-10921	11472
Sh2b3	-9120	-3065
Socs1	-79	9008
Socs6	-8798	4670
Sos1	-11977	9665
Src	8646	4243
Yes1	4717	-6854

---

---

tRNA-processing-in-the-mitochondrion

tRNA-processing-in-the-mitochondrion

metric	value
setSize	16
pMANOVA	0.00212
p.adjustMANOVA	0.0136
s.dist	0.657
s.diab	0.474
s.PMX	-0.455
p.diab	0.00104
p.PMX	0.00162

Top 20 genes

Gene	diab	PMX
mt-Co1	15116	-13378
Hsd17b10	13714	-13444
mt-Nd1	13965	-13142
mt-Nd2	13232	-13777
mt-Nd5	13692	-13085
Trnt1	12528	-12735
mt-Cytb	12116	-13032
mt-Nd6	14568	-9103
mt-Nd4	9342	-12167
mt-Nd3	5043	-3048
mt-Atp6	6410	-2243

Click HERE to show all gene set members

All member genes

	diab	PMX
Elac2	5026.0	5862.0
Hsd17b10	13714.0	-13444.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Trmt10c	-8268.0	-8771.0
Trnt1	12528.0	-12735.0

---

---

Basigin-interactions

Basigin-interactions

metric	value
setSize	24
pMANOVA	1.55e-05
p.adjustMANOVA	0.000274
s.dist	0.655
s.diab	0.553
s.PMX	-0.351
p.diab	2.67e-06
p.PMX	0.00293

Top 20 genes

Gene	diab	PMX
Atp1b1	15270	-15047
Ppia	14608	-14924
Slc7a5	14136	-14270
L1cam	15340	-13068
Slc16a8	11805	-13519
Atp1b3	9790	-13383
Slc7a11	11318	-11511
Slc16a3	11553	-11018
Slc7a9	10955	-10703
Slc16a1	14346	-8035
Slc7a6	12977	-8707
Ppil2	8843	-12309
Bsg	10831	-9772
Itgb1	5869	-13098
Mag	6844	-8991
Slc3a2	12234	-4863
Slc7a10	7075	-7559
Itga6	10749	-2876

Click HERE to show all gene set members

All member genes

	diab	PMX
Atp1b1	15270	-15047
Atp1b2	-10533	11952
Atp1b3	9790	-13383
Bsg	10831	-9772
Cav1	-3675	10920
Itga3	9099	6566
Itga6	10749	-2876
Itgb1	5869	-13098
L1cam	15340	-13068
Mag	6844	-8991
Ppia	14608	-14924
Ppil2	8843	-12309
Slc16a1	14346	-8035
Slc16a3	11553	-11018
Slc16a8	11805	-13519
Slc3a2	12234	-4863
Slc7a10	7075	-7559
Slc7a11	11318	-11511
Slc7a5	14136	-14270
Slc7a6	12977	-8707
Slc7a7	9157	5962
Slc7a8	13603	2754
Slc7a9	10955	-10703
Spn	-3874	11441

---

---

HS-GAG-degradation

HS-GAG-degradation

metric	value
setSize	20
pMANOVA	0.000179
p.adjustMANOVA	0.00182
s.dist	0.651
s.diab	-0.37
s.PMX	0.536
p.diab	0.00419
p.PMX	3.27e-05

Top 20 genes

Gene	diab	PMX
Naglu	-12533	12838
Gusb	-12493	12446
Glb1l	-12255	12476
Gpc4	-12372	11165
Hspg2	-9709	12765
Sdc2	-11747	10378
Sgsh	-8277	12291
Sdc3	-8537	11348
Ids	-10802	8409
Sdc4	-5140	12375
Gpc5	-8809	3626
Hpse2	-2919	10037
Agrn	-2557	10075

Click HERE to show all gene set members

All member genes

	diab	PMX
Agrn	-2557	10075
Glb1	-8411	-6920
Glb1l	-12255	12476
Gpc1	15341	-15137
Gpc3	5652	10299
Gpc4	-12372	11165
Gpc5	-8809	3626
Gpc6	251	6933
Gusb	-12493	12446
Hpse	323	4852
Hpse2	-2919	10037
Hspg2	-9709	12765
Ids	-10802	8409
Idua	12970	-12164
Naglu	-12533	12838
Sdc1	14043	1649
Sdc2	-11747	10378
Sdc3	-8537	11348
Sdc4	-5140	12375
Sgsh	-8277	12291

---

---

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

metric	value
setSize	107
pMANOVA	1.42e-18
p.adjustMANOVA	9.15e-17
s.dist	0.643
s.diab	0.406
s.PMX	-0.499
p.diab	3.53e-13
p.PMX	4.52e-19

Top 20 genes

Gene	diab	PMX
Uqcrb	15145	-15118
Uqcrh	15179	-15073
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Cox6b1	15253	-14902
Cox6c	15087	-15036
Sdhd	15189	-14923
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Cox5a	15090	-14747
Uqcrq	15160	-14637
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Cox7c	14740	-14896
Uqcr10	14874	-14710
Ndufb11	14492	-14964
Ndufa9	14469	-14794
Ndufb5	14481	-14745
Ndufs6	14367	-14846
Ucp2	14325	-14886

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100.0	-9605.0
Coq10a	6677.0	7304.0
Coq10b	-10247.0	-10904.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Cyc1	13836.0	-13962.0
Cycs	8402.0	-13138.0
Ecsit	-9099.0	9725.0
Etfa	-9804.0	-7984.0
Etfb	11075.0	-11149.0
Etfdh	-1913.0	-8426.0
Gm11273	8317.0	-6691.0
Lrpprc	12946.0	-11138.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Ndufa1	6937.0	-8412.0
Ndufa10	11110.0	-8885.0
Ndufa11	14920.0	-14266.0
Ndufa12	14903.0	-14234.0
Ndufa13	14115.0	-14226.0
Ndufa2	13627.0	-14858.0
Ndufa3	14864.0	-14832.0
Ndufa4	9874.0	-14669.0
Ndufa5	15074.0	-14984.0
Ndufa6	14999.0	-14781.0
Ndufa7	15178.0	-15058.0
Ndufa8	13665.0	-11997.0
Ndufa9	14469.0	-14794.0
Ndufab1	3106.0	-9458.0
Ndufaf1	-11416.0	10941.0
Ndufaf2	7440.0	-8823.0
Ndufaf3	367.0	-9795.0
Ndufaf4	-10599.0	6962.0
Ndufaf5	11575.0	-3621.0
Ndufaf6	333.0	-11082.0
Ndufaf7	9013.0	1113.0
Ndufb10	14262.0	-14459.0
Ndufb11	14492.0	-14964.0
Ndufb2	-4388.0	-8058.0
Ndufb3	12259.0	-14461.0
Ndufb4	9233.0	-12329.0
Ndufb5	14481.0	-14745.0
Ndufb6	14565.0	-13471.0
Ndufb7	13625.0	-13723.0
Ndufb9	15350.0	-14839.0
Ndufc1	14230.0	-14172.0
Ndufc2	13402.0	-13866.0
Ndufs1	7192.0	-12095.0
Ndufs2	14590.0	-13546.0
Ndufs3	14315.0	-14178.0
Ndufs4	14110.0	-14049.0
Ndufs5	13994.0	-14136.0
Ndufs6	14367.0	-14846.0
Ndufs7	11801.0	-14074.0
Ndufs8	12503.0	-14256.0
Ndufv1	7781.0	-368.0
Ndufv2	15041.0	-14992.0
Ndufv3	8348.0	4422.0
Nubpl	-8841.0	6873.0
Pm20d1	-11824.0	12257.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sdha	7583.0	-6150.0
Sdhb	14750.0	-14069.0
Sdhc	-6156.0	-7176.0
Sdhd	15189.0	-14923.0
Slc25a14	-5941.0	2591.0
Slc25a27	7582.0	-4450.0
Surf1	10929.0	-8571.0
Taco1	-5127.0	3445.0
Timmdc1	-7729.0	8038.0
Tmem126b	-11814.0	6995.0
Tmem186	-10081.0	10176.0
Trap1	-11794.0	8106.0
Ucp1	2923.0	-2898.0
Ucp2	14325.0	-14886.0
Ucp3	10070.0	-13365.0
Uqcr10	14874.0	-14710.0
Uqcr11	13121.0	-13943.0
Uqcrb	15145.0	-15118.0
Uqcrc1	12486.0	-6849.0
Uqcrc2	12361.0	-13694.0
Uqcrfs1	11242.0	-12436.0
Uqcrh	15179.0	-15073.0
Uqcrq	15160.0	-14637.0

---

---

Bicarbonate-transporters

Bicarbonate-transporters

metric	value
setSize	10
pMANOVA	1.09e-06
p.adjustMANOVA	3.36e-05
s.dist	0.631
s.diab	0.622
s.PMX	0.104
p.diab	0.000655
p.PMX	0.569

Top 20 genes

Gene	diab	PMX
Slc4a1	14778	8982
Slc4a9	13258	9326
Slc4a2	11101	9303
Slc4a3	14179	4427

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcyl2	-3998	10444.0
Slc4a1	14778	8982.0
Slc4a10	-4629	7874.5
Slc4a2	11101	9303.0
Slc4a3	14179	4427.0
Slc4a4	14911	-13072.0
Slc4a5	12171	-5339.0
Slc4a7	13723	-14904.0
Slc4a8	15202	-13045.0
Slc4a9	13258	9326.0

---

---

Influenza-Infection

Influenza-Infection

metric	value
setSize	134
pMANOVA	1.07e-20
p.adjustMANOVA	7.91e-19
s.dist	0.62
s.diab	0.423
s.PMX	-0.454
p.diab	2.72e-17
p.PMX	1.05e-19

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Calr	-12155.0	11400.0
Canx	-11724.0	5539.0
Clta	-6346.0	5123.0
Cltc	8328.0	-9844.0
Cpsf4	5771.0	-8596.0
Dnajc3	-9188.0	-13392.0
Eif2ak2	12800.0	-13739.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Grsf1	9214.0	-9055.0
Gtf2f1	10842.0	-11838.0
Gtf2f2	11210.0	-13043.0
Hsp90aa1	-12505.0	4614.0
Hspa1b	13713.0	-5345.0
Ipo5	11718.0	-12610.0
Isg15	7447.0	-9094.0
Kpna1	7639.0	-11114.0
Kpna2	-6529.0	3386.0
Kpna3	11006.0	-12959.0
Kpna4	-12402.0	11649.0
Kpnb1	10908.0	1199.0
Ndc1	13238.0	-12109.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Parp1	-4209.0	11584.0
Polr2a	5917.0	6827.0
Polr2b	-9995.0	7496.0
Polr2c	-2600.0	9289.0
Polr2d	-4100.0	39.0
Polr2e	11726.0	-9159.0
Polr2f	11374.0	-6543.0
Polr2g	11118.0	-13257.0
Polr2h	224.0	-7426.0
Polr2i	13554.0	-12640.0
Polr2j	9902.0	-6099.0
Polr2k	7520.0	-11503.0
Polr2l	6213.0	4463.0
Pom121	9659.0	-12785.0
Rae1	-2818.0	7959.0
Ran	-340.0	-458.0
Ranbp2	-1884.0	-9227.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Tgfb1	-11489.0	7819.0
Tpr	-7568.0	-3358.0
Uba52	4596.0	-6796.0
Xpo1	-10778.0	9680.0

---

---

Regulation-of-expression-of-SLITs-and-ROBOs

Regulation-of-expression-of-SLITs-and-ROBOs

metric	value
setSize	149
pMANOVA	4.28e-23
p.adjustMANOVA	3.97e-21
s.dist	0.608
s.diab	0.379
s.PMX	-0.475
p.diab	1.18e-15
p.PMX	1.16e-23

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Psmd8	14709	-14720
Psmd9	14751	-14675

Click HERE to show all gene set members

All member genes

	diab	PMX
Casc3	-213.0	8374.0
Col4a5	12326.0	7452.0
Cul2	-7656.0	2073.0
Dag1	14086.0	305.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Hoxa2	6369.0	2887.0
Ldb1	13326.0	-12215.0
Lhx2	9446.0	-6616.0
Lhx3	-665.5	3249.0
Lhx9	4055.0	-4216.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Msi1	13972.0	-10430.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Rbm8a2	-485.5	-1222.5
Rbx1	2286.0	4532.0
Rnps1	11263.0	-12563.0
Robo1	4284.0	7975.0
Robo2	-10164.0	12956.0
Robo3	-12220.0	10440.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Slit1	10290.0	-10823.0
Slit2	-9878.0	9321.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0
Usp33	-8958.0	-3443.0
Zswim8	12845.0	-11226.0

---

---

Metabolism-of-Angiotensinogen-to-Angiotensins

Metabolism-of-Angiotensinogen-to-Angiotensins

metric	value
setSize	12
pMANOVA	0.02
p.adjustMANOVA	0.0822
s.dist	0.604
s.diab	0.415
s.PMX	-0.439
p.diab	0.0128
p.PMX	0.00844

Top 20 genes

Gene	diab	PMX
Agt	15303	-15119
Ace2	15092	-15113
Atp6ap2	14483	-14615
Enpep	14915	-14165
Anpep	14717	-13487
Ctsd	14947	-9938
Cpb2	14104	-9978
Ces1a	10997	-7667

Click HERE to show all gene set members

All member genes

	diab	PMX
Ace	-12717	8439
Ace2	15092	-15113
Agt	15303	-15119
Anpep	14717	-13487
Atp6ap2	14483	-14615
Ces1a	10997	-7667
Cpb2	14104	-9978
Ctsd	14947	-9938
Ctsz	-7602	9922
Enpep	14915	-14165
Mme	-5045	-12895
Ren1	-3419	7650

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.2               GGally_2.1.2               
##  [3] ggplot2_3.4.0               reshape2_1.4.4             
##  [5] beeswarm_0.4.0              gplots_3.1.3               
##  [7] gtools_3.9.4                tibble_3.1.8               
##  [9] echarts4r_0.4.4             kableExtra_1.3.4           
## [11] dplyr_1.0.10                mitch_1.11.1               
## [13] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [15] Biobase_2.56.0              MatrixGenerics_1.8.1       
## [17] matrixStats_0.63.0          GenomicRanges_1.48.0       
## [19] GenomeInfoDb_1.32.4         IRanges_2.30.1             
## [21] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_2.0-3       ellipsis_0.3.2         XVector_0.36.0        
##  [4] rstudioapi_0.14        farver_2.1.1           bit64_4.0.5           
##  [7] AnnotationDbi_1.58.0   fansi_1.0.3            xml2_1.3.3            
## [10] codetools_0.2-18       splines_4.2.1          cachem_1.0.6          
## [13] geneplotter_1.74.0     knitr_1.41             jsonlite_1.8.3        
## [16] annotate_1.74.0        png_0.1-8              shiny_1.7.3           
## [19] compiler_4.2.1         httr_1.4.4             assertthat_0.2.1      
## [22] Matrix_1.5-3           fastmap_1.1.0          cli_3.4.1             
## [25] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
## [28] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
## [31] Rcpp_1.0.9             jquerylib_0.1.4        vctrs_0.5.1           
## [34] Biostrings_2.64.1      svglite_2.1.0          xfun_0.35             
## [37] stringr_1.4.1          rvest_1.0.3            mime_0.12             
## [40] lifecycle_1.0.3        XML_3.99-0.12          zlibbioc_1.42.0       
## [43] MASS_7.3-58.1          scales_1.2.1           promises_1.2.0.1      
## [46] parallel_4.2.1         RColorBrewer_1.1-3     yaml_2.3.6            
## [49] memoise_2.0.1          gridExtra_2.3          sass_0.4.4            
## [52] reshape_0.8.9          stringi_1.7.8          RSQLite_2.2.19        
## [55] highr_0.9              genefilter_1.78.0      caTools_1.18.2        
## [58] BiocParallel_1.30.4    rlang_1.0.6            pkgconfig_2.0.3       
## [61] systemfonts_1.0.4      bitops_1.0-7           evaluate_0.18         
## [64] lattice_0.20-45        htmlwidgets_1.5.4      labeling_0.4.2        
## [67] bit_4.0.5              tidyselect_1.2.0       plyr_1.8.8            
## [70] magrittr_2.0.3         R6_2.5.1               generics_0.1.3        
## [73] DelayedArray_0.22.0    DBI_1.1.3              pillar_1.8.1          
## [76] withr_2.5.0            survival_3.4-0         KEGGREST_1.36.3       
## [79] RCurl_1.98-1.9         crayon_1.5.2           KernSmooth_2.23-20    
## [82] utf8_1.2.2             rmarkdown_2.18         locfit_1.5-9.6        
## [85] grid_4.2.1             blob_1.2.3             digest_0.6.30         
## [88] webshot_0.5.4          xtable_1.8-4           httpuv_1.6.6          
## [91] munsell_0.5.0          viridisLite_0.4.1      bslib_0.4.1

END of report