date generated: 2024-04-16

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
rna k9a k36a
CNNM2 0.5560970 0.6489925 1.4501024
CD81 -0.7720398 0.5389497 1.0651607
DENND4C 2.3051477 0.1649949 19.0693005
RP11-211G3.2 0.0682718 8.8137554 -0.4796384
PRPF4 0.5968527 0.7500091 1.3103958
EIF3K 1.3218972 1.6403949 4.1412992

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 12944
duplicated_genes_present 0
num_profile_genes_in_sets 6447
num_profile_genes_not_in_sets 6497

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2263
num_genesets_excluded 1068
num_genesets_included 1195
Genes by sector
rna k9a k36a Count
-1 -1 -1 201
1 -1 -1 240
-1 1 -1 929
0 1 -1 1
1 1 -1 1081
1 1 0 1
-1 -1 1 978
1 -1 1 1033
1 0 1 1
-1 1 1 4180
1 1 1 4299

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 5 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.rna s.k9a s.k36a p.rna p.k9a p.k36a
Signaling by NOTCH3 40 0.000643 0.769 0.384 -0.2570 -0.0563 0.2790 0.004950 0.53800 0.00226
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 13 0.002530 0.982 0.604 0.6000 -0.0274 0.0612 0.000179 0.86400 0.70200
Visual phototransduction 46 0.003360 0.982 0.317 0.1820 -0.1380 -0.2190 0.032400 0.10700 0.01010
Protein methylation 14 0.003380 0.982 0.577 -0.2660 -0.4100 0.3070 0.085300 0.00793 0.04690
GPCR ligand binding 106 0.004640 0.982 0.204 0.0619 -0.0653 -0.1830 0.272000 0.24600 0.00118


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.rna s.k9a s.k36a p.rna p.k9a p.k36a
Signaling by NOTCH3 40 0.000643 0.769 0.3840 -2.57e-01 -0.056300 2.79e-01 0.004950 0.53800 0.00226
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 13 0.002530 0.982 0.6040 6.00e-01 -0.027400 6.12e-02 0.000179 0.86400 0.70200
Visual phototransduction 46 0.003360 0.982 0.3170 1.82e-01 -0.138000 -2.19e-01 0.032400 0.10700 0.01010
Protein methylation 14 0.003380 0.982 0.5770 -2.66e-01 -0.410000 3.07e-01 0.085300 0.00793 0.04690
GPCR ligand binding 106 0.004640 0.982 0.2040 6.19e-02 -0.065300 -1.83e-01 0.272000 0.24600 0.00118
Class B/2 (Secretin family receptors) 40 0.006240 0.982 0.3220 1.65e-01 -0.171000 -2.17e-01 0.070500 0.06130 0.01740
VEGFR2 mediated cell proliferation 17 0.006980 0.982 0.4870 4.16e-01 -0.240000 -7.89e-02 0.002970 0.08740 0.57300
activated TAK1 mediates p38 MAPK activation 18 0.008400 0.982 0.4640 3.74e-01 -0.274000 -7.82e-04 0.006020 0.04410 0.99500
NOTCH3 Intracellular Domain Regulates Transcription 18 0.008510 0.982 0.4710 -2.59e-01 -0.181000 3.50e-01 0.057400 0.18500 0.01020
Deadenylation-dependent mRNA decay 49 0.008690 0.982 0.2790 -1.72e-01 0.042300 -2.15e-01 0.037000 0.60800 0.00917
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 0.012000 0.982 0.5150 -3.32e-01 0.103000 3.80e-01 0.031500 0.50300 0.01390
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 0.012000 0.982 0.5150 -3.32e-01 0.103000 3.80e-01 0.031500 0.50300 0.01390
The phototransduction cascade 16 0.013600 0.982 0.4730 2.65e-01 -0.271000 -2.83e-01 0.066500 0.06080 0.05040
Purine catabolism 14 0.015100 0.982 0.4960 2.60e-01 -0.396000 1.46e-01 0.091700 0.01040 0.34400
Diseases of carbohydrate metabolism 27 0.017400 0.982 0.3560 -3.11e-01 0.070800 1.59e-01 0.005200 0.52500 0.15300
Signaling by NOTCH1 65 0.018500 0.982 0.2290 -1.57e-01 -0.003750 1.67e-01 0.028800 0.95800 0.01970
Nitric oxide stimulates guanylate cyclase 17 0.018700 0.982 0.4380 -2.73e-01 0.029600 -3.42e-01 0.051600 0.83300 0.01480
mRNA decay by 3’ to 5’ exoribonuclease 12 0.020100 0.982 0.5170 -4.25e-01 0.149000 -2.54e-01 0.010800 0.37000 0.12700
G-protein beta:gamma signalling 20 0.020400 0.982 0.4000 3.10e-01 -0.196000 1.60e-01 0.016500 0.12800 0.21400
NCAM signaling for neurite out-growth 40 0.020500 0.982 0.2850 -2.83e-03 0.181000 2.21e-01 0.975000 0.04830 0.01570
Antiviral mechanism by IFN-stimulated genes 75 0.022300 0.982 0.2100 1.52e-01 0.094100 -1.10e-01 0.023000 0.15900 0.10100
Activation of the AP-1 family of transcription factors 10 0.024300 0.982 0.5560 3.20e-01 0.219000 3.99e-01 0.080000 0.23100 0.02890
ISG15 antiviral mechanism 69 0.025100 0.982 0.2150 1.66e-01 0.097600 -9.68e-02 0.017300 0.16100 0.16500
Activated NOTCH1 Transmits Signal to the Nucleus 26 0.026600 0.982 0.3450 -1.66e-01 0.161000 2.56e-01 0.144000 0.15500 0.02370
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 0.027200 0.982 0.3680 -2.64e-01 0.060800 2.48e-01 0.028300 0.61400 0.03930
Processing of DNA double-strand break ends 52 0.031800 0.982 0.2390 -2.25e-01 -0.079200 1.02e-02 0.004950 0.32300 0.89900
Signaling by NOTCH 153 0.032300 0.982 0.1410 -1.09e-01 -0.048600 7.50e-02 0.020400 0.30000 0.11000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 63 0.033000 0.982 0.2170 2.01e-01 0.006340 -8.09e-02 0.005750 0.93100 0.26800
SUMOylation of transcription factors 15 0.033400 0.982 0.4390 -3.07e-01 -0.274000 -1.55e-01 0.039600 0.06650 0.29900
Ca2+ pathway 46 0.034000 0.982 0.2490 1.72e-01 -0.179000 2.29e-02 0.043100 0.03600 0.78800
Metabolism of porphyrins 13 0.034300 0.982 0.4690 -1.09e-01 -0.285000 -3.56e-01 0.495000 0.07510 0.02630
Mitochondrial translation 65 0.035300 0.982 0.2090 1.95e-01 0.043300 6.34e-02 0.006630 0.54700 0.37700
Nucleobase catabolism 26 0.035400 0.982 0.3300 2.63e-01 -0.194000 4.44e-02 0.020500 0.08650 0.69600
mTORC1-mediated signalling 21 0.035400 0.982 0.3710 1.42e-01 0.342000 -8.85e-03 0.259000 0.00662 0.94400
Processing of SMDT1 14 0.035700 0.982 0.4510 -7.56e-02 0.378000 2.35e-01 0.624000 0.01450 0.12800
Interferon Signaling 146 0.036100 0.982 0.1420 7.53e-02 0.079400 -9.06e-02 0.117000 0.09840 0.05940
HDR through Single Strand Annealing (SSA) 30 0.039500 0.982 0.3070 -2.39e-01 -0.185000 5.36e-02 0.023300 0.07970 0.61100
Platelet degranulation 84 0.040200 0.982 0.1840 -9.99e-02 -0.106000 1.13e-01 0.114000 0.09360 0.07410
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 39 0.041700 0.982 0.2630 -2.21e-01 0.017100 -1.41e-01 0.016900 0.85300 0.12800
Regulation of TP53 Activity through Methylation 16 0.042100 0.982 0.4150 -2.49e-01 0.186000 2.75e-01 0.084200 0.19700 0.05710
Inactivation, recovery and regulation of the phototransduction cascade 15 0.042700 0.982 0.4270 2.26e-01 -0.226000 -2.84e-01 0.129000 0.13000 0.05730
Apoptotic execution phase 37 0.043200 0.982 0.2720 1.90e-01 -0.149000 -1.25e-01 0.045700 0.11800 0.18900
Signalling to RAS 17 0.043500 0.982 0.3990 3.71e-01 0.130000 7.17e-02 0.008160 0.35500 0.60900
Striated Muscle Contraction 30 0.044000 0.982 0.3030 -1.98e-01 -0.221000 6.20e-02 0.061000 0.03620 0.55700
Cell Cycle Checkpoints 184 0.046600 0.982 0.1210 -9.46e-02 -0.073400 -1.92e-02 0.027300 0.08690 0.65500
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 0.046600 0.982 0.4510 7.03e-02 0.340000 2.88e-01 0.661000 0.03380 0.07270
Netrin-1 signaling 38 0.046900 0.982 0.2630 1.72e-01 -0.197000 2.58e-02 0.066500 0.03570 0.78300
Diseases associated with glycosylation precursor biosynthesis 15 0.046900 0.982 0.4260 3.11e-01 0.059700 -2.84e-01 0.036800 0.68900 0.05690
Anchoring of the basal body to the plasma membrane 84 0.047000 0.982 0.1770 9.37e-02 -0.133000 6.93e-02 0.138000 0.03530 0.27300
Fanconi Anemia Pathway 26 0.048300 0.982 0.3220 -1.72e-01 -0.082400 2.60e-01 0.129000 0.46700 0.02200
G2/M DNA damage checkpoint 49 0.048500 0.982 0.2330 -1.69e-01 -0.157000 -3.22e-02 0.041100 0.05790 0.69700
Detoxification of Reactive Oxygen Species 23 0.050600 0.982 0.3340 2.40e-01 0.122000 1.97e-01 0.046600 0.30900 0.10200
Estrogen-dependent gene expression 79 0.051500 0.982 0.1830 -1.09e-01 0.049800 1.38e-01 0.093800 0.44500 0.03470
RUNX3 regulates NOTCH signaling 12 0.051700 0.982 0.4700 -3.08e-01 -0.206000 2.89e-01 0.064900 0.21600 0.08320
Signalling to ERKs 30 0.052900 0.982 0.2930 2.82e-01 0.078800 7.90e-03 0.007470 0.45500 0.94000
DNA Double Strand Break Response 40 0.055400 0.982 0.2500 -2.23e-01 0.004320 -1.13e-01 0.014800 0.96200 0.21800
Interleukin-37 signaling 17 0.056600 0.982 0.3870 9.15e-02 0.201000 -3.18e-01 0.514000 0.15100 0.02310
cGMP effects 11 0.057400 0.982 0.4720 -2.61e-01 0.177000 -3.52e-01 0.134000 0.31000 0.04320
Mucopolysaccharidoses 11 0.058900 0.982 0.4800 -4.23e-01 -0.071200 2.15e-01 0.015200 0.68300 0.21600
Pentose phosphate pathway 11 0.060900 0.982 0.4740 2.14e-01 -0.251000 -3.41e-01 0.219000 0.15000 0.05050
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 13 0.061000 0.982 0.4310 -1.85e-01 0.060400 -3.85e-01 0.248000 0.70600 0.01630
Unfolded Protein Response (UPR) 69 0.061000 0.982 0.1870 -1.48e-01 0.088200 -7.27e-02 0.033200 0.20600 0.29700
IRF3-mediated induction of type I IFN 10 0.064700 0.982 0.4960 3.24e-01 0.361000 -1.03e-01 0.076200 0.04840 0.57100
Activation of kainate receptors upon glutamate binding 19 0.065000 0.982 0.3540 1.87e-01 -0.290000 8.06e-02 0.159000 0.02880 0.54300
ATF4 activates genes in response to endoplasmic reticulum stress 19 0.065400 0.982 0.3520 -2.86e-01 0.079000 -1.89e-01 0.030700 0.55100 0.15400
Sphingolipid de novo biosynthesis 31 0.066300 0.982 0.2760 1.44e-01 0.101000 2.13e-01 0.165000 0.33100 0.04060
NOTCH1 Intracellular Domain Regulates Transcription 44 0.068000 0.982 0.2360 -1.76e-01 -0.069600 1.40e-01 0.043200 0.42500 0.10800
Pausing and recovery of Tat-mediated HIV elongation 22 0.068100 0.982 0.3260 1.61e-01 -0.231000 1.65e-01 0.192000 0.06070 0.18000
Tat-mediated HIV elongation arrest and recovery 22 0.068100 0.982 0.3260 1.61e-01 -0.231000 1.65e-01 0.192000 0.06070 0.18000
p38MAPK events 13 0.068600 0.982 0.4250 4.18e-01 0.003110 7.82e-02 0.009060 0.98500 0.62600
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 52 0.068900 0.982 0.2160 -1.61e-01 -0.035800 1.40e-01 0.044500 0.65500 0.08200
Constitutive Signaling by NOTCH1 PEST Domain Mutants 52 0.068900 0.982 0.2160 -1.61e-01 -0.035800 1.40e-01 0.044500 0.65500 0.08200
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 52 0.068900 0.982 0.2160 -1.61e-01 -0.035800 1.40e-01 0.044500 0.65500 0.08200
Signaling by NOTCH1 PEST Domain Mutants in Cancer 52 0.068900 0.982 0.2160 -1.61e-01 -0.035800 1.40e-01 0.044500 0.65500 0.08200
Signaling by NOTCH1 in Cancer 52 0.068900 0.982 0.2160 -1.61e-01 -0.035800 1.40e-01 0.044500 0.65500 0.08200
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 0.069400 0.982 0.4690 -3.53e-01 -0.177000 2.53e-01 0.042500 0.30900 0.14700
Mitochondrial translation initiation 60 0.069700 0.982 0.1970 1.64e-01 0.048800 9.74e-02 0.027800 0.51300 0.19200
Response to elevated platelet cytosolic Ca2+ 87 0.070900 0.982 0.1670 -8.17e-02 -0.105000 9.97e-02 0.188000 0.08950 0.10800
HIV elongation arrest and recovery 24 0.071500 0.982 0.3100 1.55e-01 -0.151000 2.21e-01 0.189000 0.20000 0.06050
Pausing and recovery of HIV elongation 24 0.071500 0.982 0.3100 1.55e-01 -0.151000 2.21e-01 0.189000 0.20000 0.06050
HS-GAG biosynthesis 17 0.071600 0.982 0.3700 2.02e-01 -0.290000 -1.11e-01 0.150000 0.03860 0.43000
Glutathione conjugation 25 0.072200 0.982 0.3070 -7.36e-02 0.017000 2.97e-01 0.524000 0.88300 0.01010
Metal ion SLC transporters 14 0.073100 0.982 0.4040 -1.72e-01 0.156000 -3.31e-01 0.265000 0.31200 0.03220
SUMOylation 147 0.074700 0.982 0.1270 -1.17e-01 -0.046000 1.33e-02 0.014400 0.33700 0.78100
Recruitment of NuMA to mitotic centrosomes 67 0.075100 0.982 0.1840 1.11e-01 -0.114000 9.22e-02 0.117000 0.10600 0.19200
CS/DS degradation 10 0.075400 0.982 0.4820 -3.44e-01 0.164000 2.96e-01 0.060000 0.36800 0.10500
Cilium Assembly 154 0.075400 0.982 0.1220 8.58e-02 -0.076300 4.06e-02 0.066700 0.10300 0.38600
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 21 0.078200 0.982 0.3300 2.12e-01 -0.173000 -1.84e-01 0.092300 0.17100 0.14400
Glycosaminoglycan metabolism 78 0.078600 0.982 0.1730 -1.04e-01 -0.095800 9.95e-02 0.112000 0.14400 0.12900
SUMOylation of transcription cofactors 39 0.079300 0.982 0.2420 -1.95e-01 -0.143000 -7.25e-03 0.035000 0.12200 0.93800
NOTCH4 Intracellular Domain Regulates Transcription 17 0.079500 0.982 0.3650 -3.43e-01 -0.121000 -3.63e-02 0.014500 0.38800 0.79600
Presynaptic phase of homologous DNA pairing and strand exchange 30 0.082100 0.982 0.2760 -2.13e-01 -0.160000 7.33e-02 0.043900 0.13100 0.48700
G beta:gamma signalling through CDC42 12 0.082800 0.982 0.4290 3.48e-01 -0.250000 -7.60e-04 0.036800 0.13400 0.99600
Regulation of TP53 Activity 129 0.084300 0.982 0.1330 -8.78e-02 -0.019500 9.83e-02 0.085800 0.70300 0.05440
Signaling by Erythropoietin 21 0.086600 0.982 0.3230 -3.98e-03 -0.120000 -3.00e-01 0.975000 0.34300 0.01740
Synthesis of substrates in N-glycan biosythesis 50 0.086800 0.982 0.2120 1.95e-01 0.041700 -7.09e-02 0.017200 0.61000 0.38600
FRS-mediated FGFR4 signaling 12 0.087000 0.982 0.4240 3.83e-01 0.025500 1.81e-01 0.021700 0.87900 0.27900
Asparagine N-linked glycosylation 233 0.087500 0.982 0.0982 9.54e-02 0.019300 -1.27e-02 0.012400 0.61200 0.74000
Mitochondrial tRNA aminoacylation 20 0.089100 0.982 0.3290 -3.29e-02 0.109000 -3.09e-01 0.799000 0.39900 0.01670
trans-Golgi Network Vesicle Budding 58 0.090800 0.982 0.1920 8.88e-02 -0.168000 3.00e-02 0.243000 0.02710 0.69300
PKA-mediated phosphorylation of CREB 17 0.092000 0.982 0.3520 2.31e-01 0.050300 2.61e-01 0.098700 0.71900 0.06280
MAP kinase activation 60 0.092300 0.982 0.1870 1.30e-01 -0.028900 1.32e-01 0.081400 0.69900 0.07800
G alpha (s) signalling events 66 0.092300 0.982 0.1810 2.46e-03 0.121000 -1.34e-01 0.972000 0.08820 0.05930
Phase II - Conjugation of compounds 50 0.093600 0.982 0.2080 -8.36e-02 0.031500 1.88e-01 0.307000 0.70000 0.02150
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 76 0.094100 0.982 0.1660 1.42e-01 -0.054100 6.81e-02 0.032900 0.41500 0.30500
RHO GTPases Activate NADPH Oxidases 12 0.095100 0.982 0.4180 2.99e-01 0.159000 2.45e-01 0.072900 0.34100 0.14200
Signaling by NOTCH2 27 0.096000 0.982 0.2830 -2.34e-01 -0.063500 1.47e-01 0.035600 0.56800 0.18600
FRS-mediated FGFR3 signaling 10 0.096100 0.982 0.4570 4.37e-01 0.005880 1.34e-01 0.016700 0.97400 0.46300
Homologous DNA Pairing and Strand Exchange 32 0.096300 0.982 0.2600 -2.08e-01 -0.139000 7.04e-02 0.042000 0.17300 0.49100
MyD88 cascade initiated on plasma membrane 74 0.096500 0.982 0.1680 1.38e-01 -0.056800 7.69e-02 0.040700 0.39900 0.25300
Toll Like Receptor 10 (TLR10) Cascade 74 0.096500 0.982 0.1680 1.38e-01 -0.056800 7.69e-02 0.040700 0.39900 0.25300
Toll Like Receptor 5 (TLR5) Cascade 74 0.096500 0.982 0.1680 1.38e-01 -0.056800 7.69e-02 0.040700 0.39900 0.25300
Peroxisomal protein import 48 0.097700 0.982 0.2110 -5.42e-02 -0.036600 2.01e-01 0.516000 0.66100 0.01630
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 0.101000 0.982 0.2670 -6.97e-02 0.016400 -2.57e-01 0.516000 0.87900 0.01680
Class A/1 (Rhodopsin-like receptors) 63 0.102000 0.982 0.1810 -1.55e-02 0.000667 -1.81e-01 0.832000 0.99300 0.01330
tRNA Aminoacylation 39 0.103000 0.982 0.2310 1.19e-02 0.025900 -2.29e-01 0.898000 0.78000 0.01350
FRS-mediated FGFR2 signaling 12 0.104000 0.982 0.4100 3.56e-01 0.009180 2.03e-01 0.032700 0.95600 0.22200
Signaling by Non-Receptor Tyrosine Kinases 44 0.104000 0.982 0.2180 -1.70e-01 0.057200 1.24e-01 0.051500 0.51200 0.15600
Signaling by PTK6 44 0.104000 0.982 0.2180 -1.70e-01 0.057200 1.24e-01 0.051500 0.51200 0.15600
ECM proteoglycans 34 0.108000 0.982 0.2460 -1.30e-01 0.041100 2.05e-01 0.191000 0.67800 0.03850
Transcriptional Regulation by MECP2 44 0.108000 0.982 0.2170 -1.06e-01 -0.067700 1.77e-01 0.226000 0.43700 0.04200
Regulation of TP53 Activity through Association with Co-factors 11 0.108000 0.982 0.4250 2.33e-01 0.009160 3.55e-01 0.181000 0.95800 0.04160
Loss of Nlp from mitotic centrosomes 59 0.109000 0.982 0.1840 1.08e-01 -0.115000 9.37e-02 0.151000 0.12600 0.21400
Loss of proteins required for interphase microtubule organization from the centrosome 59 0.109000 0.982 0.1840 1.08e-01 -0.115000 9.37e-02 0.151000 0.12600 0.21400
Chondroitin sulfate/dermatan sulfate metabolism 34 0.109000 0.982 0.2470 -1.75e-01 -0.028700 1.71e-01 0.077000 0.77200 0.08450
SHC-mediated cascade:FGFR4 10 0.111000 0.982 0.4460 4.21e-01 0.101000 1.06e-01 0.021000 0.57900 0.56200
The role of Nef in HIV-1 replication and disease pathogenesis 20 0.112000 0.982 0.3180 -2.97e-01 -0.105000 4.21e-02 0.021500 0.41600 0.74500
Abortive elongation of HIV-1 transcript in the absence of Tat 18 0.113000 0.982 0.3310 1.82e-01 -0.254000 1.07e-01 0.181000 0.06190 0.43200
MyD88 dependent cascade initiated on endosome 77 0.116000 0.982 0.1590 1.37e-01 -0.052500 6.15e-02 0.038100 0.42600 0.35100
Toll Like Receptor 7/8 (TLR7/8) Cascade 77 0.116000 0.982 0.1590 1.37e-01 -0.052500 6.15e-02 0.038100 0.42600 0.35100
PKA activation 15 0.117000 0.982 0.3590 2.36e-01 0.116000 2.45e-01 0.113000 0.43900 0.10100
SUMO E3 ligases SUMOylate target proteins 141 0.117000 0.982 0.1190 -1.07e-01 -0.050800 1.20e-02 0.028200 0.29900 0.80600
Signaling by cytosolic FGFR1 fusion mutants 18 0.119000 0.982 0.3280 -3.23e-01 -0.002120 -5.86e-02 0.017800 0.98800 0.66700
Plasma lipoprotein assembly, remodeling, and clearance 47 0.119000 0.982 0.2020 -1.11e-01 0.108000 -1.30e-01 0.189000 0.20100 0.12300
Other interleukin signaling 16 0.121000 0.982 0.3460 1.27e-01 -0.277000 1.64e-01 0.381000 0.05470 0.25700
Class I peroxisomal membrane protein import 14 0.123000 0.982 0.3700 -4.99e-02 0.357000 -8.51e-02 0.747000 0.02080 0.58200
Interleukin-17 signaling 63 0.124000 0.982 0.1730 1.02e-01 -0.019100 1.39e-01 0.163000 0.79300 0.05660
TCF dependent signaling in response to WNT 136 0.125000 0.982 0.1200 -4.89e-02 -0.108000 -1.77e-02 0.326000 0.03060 0.72300
Signaling by GPCR 319 0.125000 0.982 0.0793 6.52e-02 0.013600 -4.31e-02 0.046500 0.67800 0.18800
Toll Like Receptor 3 (TLR3) Cascade 82 0.126000 0.982 0.1520 1.48e-01 0.004000 3.44e-02 0.020400 0.95000 0.59100
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 0.126000 0.982 0.4130 1.64e-01 -0.141000 3.53e-01 0.348000 0.41800 0.04290
Assembly and cell surface presentation of NMDA receptors 15 0.126000 0.982 0.3560 -3.13e-01 -0.128000 -1.09e-01 0.035700 0.39000 0.46400
Centrosome maturation 67 0.127000 0.982 0.1670 9.08e-02 -0.097500 1.02e-01 0.199000 0.16800 0.15100
Recruitment of mitotic centrosome proteins and complexes 67 0.127000 0.982 0.1670 9.08e-02 -0.097500 1.02e-01 0.199000 0.16800 0.15100
Signaling by Insulin receptor 47 0.127000 0.982 0.2030 1.65e-01 0.118000 -1.78e-03 0.051000 0.16100 0.98300
FCERI mediated MAPK activation 25 0.129000 0.982 0.2740 1.31e-01 0.209000 1.20e-01 0.255000 0.07100 0.29800
G beta:gamma signalling through PLC beta 12 0.130000 0.982 0.3930 2.82e-01 -0.241000 1.30e-01 0.091300 0.14800 0.43600
Presynaptic function of Kainate receptors 12 0.130000 0.982 0.3930 2.82e-01 -0.241000 1.30e-01 0.091300 0.14800 0.43600
Downregulation of ERBB2:ERBB3 signaling 12 0.132000 0.982 0.3960 -2.09e-01 0.216000 2.58e-01 0.210000 0.19500 0.12200
mRNA 3’-end processing 46 0.134000 0.982 0.2020 5.46e-03 0.201000 -8.31e-03 0.949000 0.01820 0.92200
G2/M Checkpoints 102 0.134000 0.982 0.1360 -8.02e-02 -0.110000 3.94e-03 0.163000 0.05480 0.94500
Glycogen storage diseases 13 0.134000 0.982 0.3780 -3.08e-01 0.190000 1.08e-01 0.054400 0.23500 0.49800
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 0.135000 0.982 0.2900 -2.64e-01 -0.106000 -5.88e-02 0.032400 0.38800 0.63300
Regulation of actin dynamics for phagocytic cup formation 49 0.136000 0.982 0.1950 2.17e-02 0.191000 -3.06e-02 0.793000 0.02060 0.71200
Cellular hexose transport 10 0.136000 0.982 0.4310 -8.22e-02 -0.003260 4.23e-01 0.653000 0.98600 0.02040
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 0.140000 0.982 0.4230 3.56e-01 -0.048700 2.24e-01 0.051600 0.79000 0.21900
Branched-chain amino acid catabolism 16 0.140000 0.982 0.3370 -3.01e-01 0.149000 2.57e-02 0.037100 0.30100 0.85900
SUMOylation of DNA methylation proteins 15 0.141000 0.982 0.3470 9.95e-02 -0.324000 7.69e-02 0.505000 0.03000 0.60600
Diseases associated with the TLR signaling cascade 18 0.142000 0.982 0.3170 -1.29e-02 -0.056100 -3.12e-01 0.925000 0.68000 0.02200
Diseases of Immune System 18 0.142000 0.982 0.3170 -1.29e-02 -0.056100 -3.12e-01 0.925000 0.68000 0.02200
Mitochondrial translation elongation 59 0.144000 0.982 0.1740 1.44e-01 0.056800 8.03e-02 0.056400 0.45100 0.28600
Toll Like Receptor 9 (TLR9) Cascade 80 0.146000 0.982 0.1490 1.31e-01 -0.050200 5.02e-02 0.043600 0.43800 0.43800
Iron uptake and transport 41 0.147000 0.982 0.2090 -2.61e-02 0.207000 -8.06e-03 0.773000 0.02180 0.92900
Signaling by NOTCH4 71 0.147000 0.982 0.1600 -1.23e-01 -0.098700 2.93e-02 0.073300 0.15100 0.66900
Signaling by ERBB2 41 0.148000 0.982 0.2090 -1.24e-02 0.208000 -4.48e-03 0.891000 0.02100 0.96000
SHC-mediated cascade:FGFR2 10 0.149000 0.982 0.4200 3.89e-01 0.081800 1.33e-01 0.033000 0.65400 0.46600
Protein localization 121 0.151000 0.982 0.1230 -7.85e-02 0.001100 9.41e-02 0.137000 0.98300 0.07430
GABA receptor activation 24 0.152000 0.982 0.2700 2.69e-02 0.143000 2.28e-01 0.820000 0.22600 0.05340
Mitochondrial translation termination 60 0.152000 0.982 0.1710 1.48e-01 0.037300 7.72e-02 0.048300 0.61800 0.30100
Dectin-2 family 10 0.152000 0.982 0.4180 -4.13e-01 0.055100 -3.56e-02 0.023700 0.76300 0.84500
CLEC7A (Dectin-1) induces NFAT activation 11 0.154000 0.982 0.4010 -1.60e-01 -0.365000 4.81e-02 0.358000 0.03620 0.78200
Programmed Cell Death 142 0.154000 0.982 0.1120 7.04e-02 -0.072900 -4.67e-02 0.148000 0.13500 0.33700
RNA Polymerase III Abortive And Retractive Initiation 34 0.155000 0.982 0.2270 1.74e-01 0.128000 6.87e-02 0.079100 0.19700 0.48900
RNA Polymerase III Transcription 34 0.155000 0.982 0.2270 1.74e-01 0.128000 6.87e-02 0.079100 0.19700 0.48900
Prolactin receptor signaling 10 0.155000 0.982 0.4210 1.54e-01 0.009590 -3.92e-01 0.400000 0.95800 0.03190
Pre-NOTCH Processing in Golgi 15 0.159000 0.982 0.3420 -2.63e-01 0.041000 2.16e-01 0.078300 0.78400 0.14800
AURKA Activation by TPX2 60 0.160000 0.982 0.1680 9.02e-02 -0.101000 1.00e-01 0.228000 0.17700 0.17900
Transmission across Chemical Synapses 139 0.160000 0.982 0.1110 8.32e-02 0.013200 7.20e-02 0.091100 0.78800 0.14400
Muscle contraction 136 0.162000 0.982 0.1130 -1.86e-02 -0.094400 5.99e-02 0.708000 0.05780 0.22800
Rho GTPase cycle 113 0.162000 0.982 0.1220 1.04e-01 0.001060 6.54e-02 0.057800 0.98400 0.23100
Mitochondrial calcium ion transport 21 0.163000 0.982 0.2850 -6.32e-02 0.269000 7.09e-02 0.616000 0.03320 0.57400
ZBP1(DAI) mediated induction of type I IFNs 16 0.164000 0.982 0.3300 1.85e-01 -0.010900 -2.73e-01 0.201000 0.94000 0.05890
SUMOylation of intracellular receptors 26 0.165000 0.982 0.2590 -1.96e-01 -0.012600 1.69e-01 0.084500 0.91100 0.13600
FRS-mediated FGFR1 signaling 13 0.166000 0.982 0.3570 2.72e-01 0.027900 2.31e-01 0.090100 0.86200 0.15000
Diseases of signal transduction 288 0.166000 0.982 0.0781 -5.42e-02 -0.055600 7.91e-03 0.115000 0.10600 0.81800
PKA activation in glucagon signalling 15 0.169000 0.982 0.3320 1.84e-01 0.148000 2.34e-01 0.217000 0.32100 0.11700
Negative regulators of DDX58/IFIH1 signaling 33 0.170000 0.982 0.2250 -2.27e-02 0.224000 -9.86e-03 0.822000 0.02610 0.92200
Formation of apoptosome 11 0.171000 0.982 0.3920 3.61e-01 0.146000 -5.09e-02 0.038300 0.40300 0.77000
Regulation of the apoptosome activity 11 0.171000 0.982 0.3920 3.61e-01 0.146000 -5.09e-02 0.038300 0.40300 0.77000
Interleukin-12 family signaling 35 0.171000 0.982 0.2190 -3.48e-02 0.002520 2.17e-01 0.722000 0.97900 0.02660
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 0.172000 0.982 0.4100 -3.53e-01 -0.209000 -3.94e-03 0.053200 0.25300 0.98300
MyD88-independent TLR4 cascade 84 0.173000 0.982 0.1410 1.39e-01 -0.000722 2.20e-02 0.027900 0.99100 0.72800
TRIF(TICAM1)-mediated TLR4 signaling 84 0.173000 0.982 0.1410 1.39e-01 -0.000722 2.20e-02 0.027900 0.99100 0.72800
COPII-mediated vesicle transport 55 0.173000 0.982 0.1750 1.58e-01 -0.024300 -7.10e-02 0.042600 0.75500 0.36300
Transferrin endocytosis and recycling 20 0.174000 0.982 0.2900 1.70e-01 0.233000 -2.46e-02 0.187000 0.07110 0.84900
Toll-like Receptor Cascades 117 0.175000 0.982 0.1190 1.19e-01 -0.005680 -6.29e-03 0.026300 0.91600 0.90700
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 0.175000 0.982 0.2940 -2.48e-02 -0.193000 -2.21e-01 0.852000 0.14600 0.09580
Neuronal System 195 0.176000 0.982 0.0921 6.94e-02 0.039600 4.58e-02 0.095800 0.34200 0.27200
Cell death signalling via NRAGE, NRIF and NADE 58 0.178000 0.982 0.1690 -3.75e-02 0.075300 1.46e-01 0.621000 0.32200 0.05440
Apoptotic cleavage of cellular proteins 28 0.179000 0.982 0.2430 1.77e-01 -0.110000 -1.25e-01 0.105000 0.31500 0.25300
ESR-mediated signaling 132 0.179000 0.982 0.1120 -1.99e-02 0.037300 1.04e-01 0.694000 0.46000 0.04010
Hedgehog ‘off’ state 88 0.179000 0.982 0.1350 1.06e-01 -0.003840 8.45e-02 0.087500 0.95000 0.17100
Interleukin receptor SHC signaling 15 0.180000 0.982 0.3300 -1.35e-02 0.087500 -3.18e-01 0.928000 0.55700 0.03310
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 75 0.182000 0.982 0.1480 -1.32e-01 -0.066300 -7.40e-03 0.048300 0.32100 0.91200
Transport of Mature Transcript to Cytoplasm 69 0.185000 0.982 0.1540 6.07e-02 0.140000 -2.09e-02 0.384000 0.04460 0.76400
NOD1/2 Signaling Pathway 29 0.185000 0.982 0.2350 1.13e-01 -0.187000 -8.74e-02 0.294000 0.08110 0.41600
Transport of Mature mRNA derived from an Intron-Containing Transcript 61 0.186000 0.982 0.1640 9.90e-02 0.123000 -4.45e-02 0.181000 0.09660 0.54900
Regulation of PLK1 Activity at G2/M Transition 73 0.190000 0.982 0.1460 1.07e-01 -0.060500 7.93e-02 0.114000 0.37200 0.24200
Regulation of HSF1-mediated heat shock response 68 0.190000 0.982 0.1550 8.57e-02 0.078500 -1.03e-01 0.222000 0.26300 0.14400
Formation of Incision Complex in GG-NER 39 0.191000 0.982 0.2040 -1.77e-01 -0.017800 9.85e-02 0.055300 0.84700 0.28700
RNA Polymerase III Transcription Initiation 29 0.193000 0.982 0.2330 1.15e-01 0.168000 1.14e-01 0.286000 0.11800 0.29000
XBP1(S) activates chaperone genes 39 0.193000 0.982 0.2010 -5.63e-02 0.177000 -7.63e-02 0.543000 0.05630 0.41000
STING mediated induction of host immune responses 12 0.193000 0.982 0.3650 2.33e-01 0.272000 -7.31e-02 0.163000 0.10300 0.66100
KSRP (KHSRP) binds and destabilizes mRNA 13 0.195000 0.982 0.3480 -3.47e-01 -0.024700 9.57e-03 0.030500 0.87700 0.95200
Formation of HIV elongation complex in the absence of HIV Tat 33 0.196000 0.982 0.2160 1.44e-01 0.010500 1.60e-01 0.151000 0.91700 0.11200
ADP signalling through P2Y purinoceptor 1 14 0.196000 0.982 0.3330 1.49e-01 -0.297000 7.68e-03 0.333000 0.05410 0.96000
RNA Polymerase III Transcription Initiation From Type 1 Promoter 22 0.197000 0.982 0.2650 9.46e-02 0.178000 1.73e-01 0.442000 0.14900 0.16100
Pyruvate metabolism and Citric Acid (TCA) cycle 48 0.198000 0.982 0.1800 1.51e-01 -0.097100 -9.69e-03 0.070900 0.24500 0.90800
Bile acid and bile salt metabolism 24 0.198000 0.982 0.2560 -2.31e-01 -0.109000 4.93e-03 0.049900 0.35500 0.96700
Synthesis of bile acids and bile salts 24 0.198000 0.982 0.2560 -2.31e-01 -0.109000 4.93e-03 0.049900 0.35500 0.96700
GPCR downstream signalling 294 0.199000 0.982 0.0744 5.44e-02 0.036800 -3.48e-02 0.110000 0.27900 0.30700
Infectious disease 289 0.199000 0.982 0.0739 1.36e-02 -0.051200 5.16e-02 0.693000 0.13600 0.13300
Beta-catenin independent WNT signaling 114 0.200000 0.982 0.1160 5.05e-02 -0.099100 3.44e-02 0.352000 0.06810 0.52700
Receptor-type tyrosine-protein phosphatases 11 0.200000 0.982 0.3750 2.66e-02 -0.141000 3.46e-01 0.879000 0.41700 0.04680
Regulation of beta-cell development 17 0.202000 0.982 0.3050 -2.13e-01 -0.015900 2.17e-01 0.128000 0.90900 0.12200
Gastrin-CREB signalling pathway via PKC and MAPK 13 0.202000 0.982 0.3450 3.04e-01 0.157000 4.00e-02 0.057400 0.32600 0.80300
MicroRNA (miRNA) biogenesis 20 0.203000 0.982 0.2770 4.91e-03 -0.032300 2.75e-01 0.970000 0.80200 0.03320
DNA Repair 232 0.204000 0.982 0.0830 -6.12e-02 -0.027000 4.92e-02 0.110000 0.48000 0.19800
Neurexins and neuroligins 29 0.204000 0.982 0.2320 2.17e-01 0.007610 -8.04e-02 0.043200 0.94300 0.45400
Downregulation of ERBB2 signaling 22 0.205000 0.982 0.2650 -1.58e-01 0.140000 1.59e-01 0.200000 0.25500 0.19500
Metabolism of water-soluble vitamins and cofactors 86 0.205000 0.982 0.1330 1.25e-01 0.020800 4.00e-02 0.044900 0.73900 0.52200
Interferon alpha/beta signaling 41 0.205000 0.982 0.1940 3.45e-02 0.104000 -1.60e-01 0.703000 0.24700 0.07590
Apoptosis 140 0.206000 0.982 0.1050 7.24e-02 -0.061400 -4.47e-02 0.140000 0.21100 0.36200
IRE1alpha activates chaperones 40 0.207000 0.982 0.1950 -5.24e-02 0.173000 -7.12e-02 0.567000 0.05790 0.43600
RHO GTPases Activate WASPs and WAVEs 31 0.208000 0.982 0.2220 1.53e-01 0.159000 2.39e-02 0.140000 0.12600 0.81800
BMAL1:CLOCK,NPAS2 activates circadian gene expression 23 0.208000 0.982 0.2570 -2.56e-01 0.013100 6.72e-03 0.033300 0.91400 0.95600
Regulation of PTEN mRNA translation 12 0.209000 0.982 0.3530 1.53e-01 -0.195000 2.51e-01 0.358000 0.24300 0.13200
VxPx cargo-targeting to cilium 15 0.210000 0.982 0.3160 -3.57e-02 -0.205000 -2.39e-01 0.811000 0.17000 0.11000
Interleukin-2 family signaling 26 0.210000 0.982 0.2390 -1.08e-01 0.123000 -1.74e-01 0.341000 0.27700 0.12400
Voltage gated Potassium channels 10 0.211000 0.982 0.3880 3.08e-03 0.385000 4.61e-02 0.987000 0.03500 0.80100
Organelle biogenesis and maintenance 221 0.211000 0.982 0.0825 4.18e-02 -0.052300 4.82e-02 0.285000 0.18200 0.21800
Metabolism of non-coding RNA 46 0.211000 0.982 0.1810 1.50e-01 -0.083900 -5.78e-02 0.078800 0.32500 0.49800
snRNP Assembly 46 0.211000 0.982 0.1810 1.50e-01 -0.083900 -5.78e-02 0.078800 0.32500 0.49800
Chondroitin sulfate biosynthesis 14 0.211000 0.982 0.3280 -3.54e-02 0.051900 3.22e-01 0.818000 0.73700 0.03690
Metabolism of steroids 100 0.211000 0.982 0.1230 -5.51e-02 -0.083800 -7.05e-02 0.342000 0.14800 0.22400
Interleukin-1 signaling 83 0.212000 0.982 0.1340 1.06e-01 -0.078800 2.09e-02 0.094800 0.21500 0.74200
Sema3A PAK dependent Axon repulsion 14 0.214000 0.982 0.3300 -3.01e-01 -0.048900 1.26e-01 0.051600 0.75100 0.41400
TP53 Regulates Transcription of Cell Cycle Genes 37 0.214000 0.982 0.2020 1.45e-01 -0.080200 -1.15e-01 0.127000 0.39900 0.22600
NRAGE signals death through JNK 44 0.215000 0.982 0.1840 -2.00e-02 0.121000 1.37e-01 0.818000 0.16500 0.11600
MAPK targets/ Nuclear events mediated by MAP kinases 29 0.216000 0.982 0.2250 7.06e-02 -0.033300 2.11e-01 0.511000 0.75700 0.04890
DDX58/IFIH1-mediated induction of interferon-alpha/beta 55 0.216000 0.982 0.1660 6.48e-02 0.152000 -1.23e-02 0.406000 0.05160 0.87500
Glucagon signaling in metabolic regulation 23 0.216000 0.982 0.2520 2.01e-01 0.001340 1.52e-01 0.095400 0.99100 0.20700
Signaling by WNT 202 0.217000 0.982 0.0865 -9.47e-03 -0.085700 6.74e-03 0.817000 0.03620 0.86900
Activation of HOX genes during differentiation 47 0.217000 0.982 0.1780 -1.37e-01 -0.103000 -4.73e-02 0.104000 0.22300 0.57500
Activation of anterior HOX genes in hindbrain development during early embryogenesis 47 0.217000 0.982 0.1780 -1.37e-01 -0.103000 -4.73e-02 0.104000 0.22300 0.57500
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 79 0.218000 0.982 0.1360 1.12e-01 -0.039600 6.66e-02 0.086900 0.54300 0.30700
Toll Like Receptor 2 (TLR2) Cascade 79 0.218000 0.982 0.1360 1.12e-01 -0.039600 6.66e-02 0.086900 0.54300 0.30700
Toll Like Receptor TLR1:TLR2 Cascade 79 0.218000 0.982 0.1360 1.12e-01 -0.039600 6.66e-02 0.086900 0.54300 0.30700
Toll Like Receptor TLR6:TLR2 Cascade 79 0.218000 0.982 0.1360 1.12e-01 -0.039600 6.66e-02 0.086900 0.54300 0.30700
Myogenesis 25 0.218000 0.982 0.2410 2.22e-01 -0.047100 8.09e-02 0.054200 0.68300 0.48400
FGFR1 mutant receptor activation 24 0.219000 0.982 0.2470 -2.45e-01 0.011100 -3.19e-02 0.037800 0.92500 0.78700
Lysine catabolism 10 0.222000 0.982 0.3830 2.24e-01 0.298000 9.01e-02 0.219000 0.10300 0.62200
Nuclear Events (kinase and transcription factor activation) 23 0.222000 0.982 0.2520 4.85e-02 -0.138000 2.05e-01 0.687000 0.25400 0.08840
Glutamate and glutamine metabolism 11 0.224000 0.982 0.3600 -2.31e-01 0.019700 -2.76e-01 0.185000 0.91000 0.11300
G alpha (12/13) signalling events 56 0.224000 0.982 0.1610 6.24e-02 0.088500 1.19e-01 0.420000 0.25200 0.12500
Synthesis of IP3 and IP4 in the cytosol 22 0.224000 0.982 0.2570 -1.00e-02 -0.256000 -2.63e-02 0.935000 0.03780 0.83100
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 0.225000 0.982 0.2850 -1.97e-02 -0.095000 2.68e-01 0.885000 0.48500 0.04900
Signaling by Nuclear Receptors 188 0.226000 0.982 0.0888 -1.89e-02 0.017900 8.49e-02 0.656000 0.67300 0.04550
TP53 Regulates Transcription of DNA Repair Genes 48 0.226000 0.982 0.1730 8.66e-02 0.056500 1.38e-01 0.300000 0.49800 0.09730
G beta:gamma signalling through PI3Kgamma 14 0.226000 0.982 0.3190 2.56e-01 -0.144000 1.24e-01 0.097000 0.35200 0.42200
Uptake and function of anthrax toxins 11 0.227000 0.982 0.3640 -5.06e-02 -0.344000 1.07e-01 0.771000 0.04800 0.54000
NR1H2 and NR1H3-mediated signaling 37 0.229000 0.982 0.2000 -1.42e-01 -0.089700 1.08e-01 0.134000 0.34500 0.25500
Zinc transporters 10 0.229000 0.982 0.3800 -2.99e-02 0.301000 -2.29e-01 0.870000 0.09890 0.21000
The citric acid (TCA) cycle and respiratory electron transport 118 0.229000 0.982 0.1110 9.39e-03 -0.104000 -3.56e-02 0.860000 0.05050 0.50500
Activation of ATR in response to replication stress 26 0.230000 0.982 0.2370 -7.70e-02 -0.217000 5.60e-02 0.497000 0.05610 0.62100
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 0.232000 0.982 0.2980 3.07e-02 0.241000 1.74e-01 0.832000 0.09580 0.22900
Role of LAT2/NTAL/LAB on calcium mobilization 12 0.234000 0.982 0.3410 -2.55e-01 0.153000 -1.67e-01 0.126000 0.36000 0.31700
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 12 0.234000 0.982 0.3470 -1.16e-01 -0.055700 3.22e-01 0.488000 0.73800 0.05310
Plasma lipoprotein remodeling 15 0.234000 0.982 0.3060 -1.05e-01 0.208000 -1.99e-01 0.481000 0.16300 0.18200
Interferon gamma signaling 60 0.234000 0.982 0.1540 -4.04e-02 0.127000 -7.69e-02 0.589000 0.08950 0.30400
DNA Damage Recognition in GG-NER 34 0.235000 0.982 0.2050 -3.92e-02 0.078100 1.85e-01 0.693000 0.43100 0.06190
SLC transporter disorders 58 0.236000 0.982 0.1570 2.26e-02 -0.065300 -1.41e-01 0.766000 0.39000 0.06430
Cardiac conduction 77 0.237000 0.982 0.1340 9.67e-02 -0.069800 6.21e-02 0.143000 0.29000 0.34700
Cell surface interactions at the vascular wall 75 0.239000 0.982 0.1370 1.16e-01 0.069600 2.32e-02 0.082500 0.29800 0.72800
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 13 0.242000 0.982 0.3240 -2.33e-01 0.026800 -2.23e-01 0.145000 0.86700 0.16300
Formation of the beta-catenin:TCF transactivating complex 29 0.243000 0.982 0.2210 -1.96e-01 -0.099900 1.50e-02 0.067600 0.35200 0.88900
G-protein activation 15 0.243000 0.982 0.3080 2.73e-01 0.052000 -1.33e-01 0.067600 0.72700 0.37100
Platelet Aggregation (Plug Formation) 23 0.243000 0.982 0.2460 -1.69e-01 0.166000 6.33e-02 0.160000 0.16800 0.60000
p75NTR recruits signalling complexes 11 0.243000 0.982 0.3550 3.13e-02 -0.027900 3.53e-01 0.858000 0.87300 0.04290
HDR through Homologous Recombination (HRR) 49 0.245000 0.982 0.1700 -1.22e-01 -0.094300 7.18e-02 0.139000 0.25400 0.38500
Activated NTRK2 signals through FRS2 and FRS3 10 0.246000 0.982 0.3710 3.20e-01 0.158000 1.03e-01 0.079800 0.38800 0.57100
Inositol phosphate metabolism 39 0.246000 0.982 0.1900 -6.18e-02 -0.175000 3.75e-02 0.505000 0.05850 0.68500
RNA Polymerase III Transcription Initiation From Type 3 Promoter 22 0.247000 0.982 0.2500 1.66e-01 0.167000 8.62e-02 0.179000 0.17600 0.48400
Mitotic Prometaphase 131 0.248000 0.982 0.1030 3.89e-02 -0.092000 2.32e-02 0.443000 0.06950 0.64800
Cellular response to heat stress 84 0.248000 0.982 0.1290 2.77e-02 0.082000 -9.60e-02 0.661000 0.19400 0.12900
Reproduction 47 0.249000 0.982 0.1700 -1.52e-01 0.077400 -6.44e-03 0.072300 0.35900 0.93900
Long-term potentiation 13 0.251000 0.982 0.3230 -2.47e-01 -0.148000 -1.45e-01 0.123000 0.35500 0.36400
DAP12 signaling 20 0.252000 0.982 0.2610 -4.42e-02 0.254000 -4.10e-02 0.732000 0.04940 0.75100
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 11 0.253000 0.982 0.3540 2.34e-01 -0.135000 -2.28e-01 0.179000 0.43700 0.19100
Triglyceride catabolism 16 0.254000 0.982 0.2930 -6.27e-02 -0.140000 2.50e-01 0.664000 0.33300 0.08310
Golgi Associated Vesicle Biogenesis 44 0.256000 0.982 0.1750 4.81e-02 -0.165000 3.23e-02 0.581000 0.05820 0.71100
Negative regulation of FGFR4 signaling 21 0.256000 0.982 0.2530 2.38e-01 0.063600 5.72e-02 0.058800 0.61400 0.65000
SHC-mediated cascade:FGFR1 11 0.256000 0.982 0.3480 2.86e-01 0.097300 1.72e-01 0.100000 0.57600 0.32400
CASP8 activity is inhibited 10 0.257000 0.982 0.3690 1.06e-01 0.345000 -7.56e-02 0.562000 0.05860 0.67900
Dimerization of procaspase-8 10 0.257000 0.982 0.3690 1.06e-01 0.345000 -7.56e-02 0.562000 0.05860 0.67900
Regulation by c-FLIP 10 0.257000 0.982 0.3690 1.06e-01 0.345000 -7.56e-02 0.562000 0.05860 0.67900
Platelet homeostasis 61 0.258000 0.982 0.1490 -8.32e-02 -0.121000 -2.59e-02 0.262000 0.10300 0.72600
COPI-dependent Golgi-to-ER retrograde traffic 58 0.260000 0.982 0.1520 7.32e-02 0.119000 6.00e-02 0.335000 0.11700 0.43000
Fcgamma receptor (FCGR) dependent phagocytosis 69 0.261000 0.982 0.1410 5.66e-02 0.099900 -8.15e-02 0.417000 0.15200 0.24200
Regulation of PTEN gene transcription 56 0.262000 0.982 0.1530 9.15e-02 -0.083100 9.02e-02 0.237000 0.28300 0.24300
G alpha (i) signalling events 160 0.264000 0.982 0.0923 7.13e-02 -0.013400 -5.71e-02 0.121000 0.77000 0.21400
Negative regulation of MAPK pathway 39 0.265000 0.982 0.1860 -1.13e-01 -0.126000 7.80e-02 0.221000 0.17400 0.39900
Oxidative Stress Induced Senescence 63 0.266000 0.982 0.1440 1.04e-01 -0.057900 7.97e-02 0.152000 0.42700 0.27400
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 0.267000 0.982 0.2580 -2.33e-01 0.035600 1.06e-01 0.071700 0.78300 0.41000
Adherens junctions interactions 14 0.267000 0.982 0.3060 3.04e-01 -0.011300 3.25e-02 0.049000 0.94200 0.83300
SRP-dependent cotranslational protein targeting to membrane 76 0.268000 0.982 0.1330 -8.12e-02 -0.005300 1.06e-01 0.221000 0.93600 0.11200
Smooth Muscle Contraction 35 0.268000 0.982 0.1960 -1.51e-01 -0.105000 6.82e-02 0.122000 0.28400 0.48500
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 15 0.268000 0.982 0.2980 -2.12e-01 -0.209000 1.76e-02 0.156000 0.16100 0.90600
MECP2 regulates neuronal receptors and channels 11 0.269000 0.982 0.3460 -1.79e-01 0.215000 2.03e-01 0.305000 0.21600 0.24300
G alpha (q) signalling events 78 0.270000 0.982 0.1290 1.20e-01 -0.046900 5.40e-03 0.066500 0.47500 0.93400
Platelet calcium homeostasis 19 0.270000 0.982 0.2650 -1.26e-01 -0.186000 1.41e-01 0.342000 0.16100 0.28700
Tie2 Signaling 14 0.272000 0.982 0.3080 2.38e-01 0.164000 -1.06e-01 0.123000 0.28800 0.49100
Cargo trafficking to the periciliary membrane 38 0.272000 0.982 0.1850 5.42e-02 -0.158000 -7.91e-02 0.564000 0.09180 0.39900
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 0.272000 0.982 0.2020 -1.55e-01 0.097300 8.67e-02 0.130000 0.34100 0.39600
Neutrophil degranulation 310 0.274000 0.982 0.0651 1.98e-02 -0.033600 5.21e-02 0.551000 0.31200 0.11600
HSF1 activation 22 0.278000 0.982 0.2390 -1.34e-01 0.063000 -1.88e-01 0.275000 0.60900 0.12700
Toll Like Receptor 4 (TLR4) Cascade 103 0.278000 0.982 0.1120 1.11e-01 0.009400 5.77e-03 0.051000 0.86900 0.92000
Processing of Intronless Pre-mRNAs 17 0.280000 0.982 0.2730 -1.41e-01 0.233000 -1.25e-02 0.314000 0.09590 0.92900
mTOR signalling 37 0.280000 0.982 0.1860 8.29e-02 0.162000 3.94e-02 0.383000 0.08810 0.67800
Negative regulation of FGFR3 signaling 19 0.283000 0.982 0.2590 2.52e-01 0.057300 1.96e-02 0.057600 0.66500 0.88200
FOXO-mediated transcription 51 0.283000 0.982 0.1590 1.51e-01 0.038500 -3.41e-02 0.063000 0.63500 0.67400
Aquaporin-mediated transport 31 0.283000 0.982 0.2000 1.61e-01 -0.023600 1.17e-01 0.121000 0.82000 0.26000
Neddylation 190 0.286000 0.982 0.0822 -8.15e-02 -0.011000 2.41e-03 0.053600 0.79400 0.95500
CaM pathway 29 0.287000 0.982 0.2070 7.76e-02 0.099300 1.65e-01 0.470000 0.35500 0.12500
Calmodulin induced events 29 0.287000 0.982 0.2070 7.76e-02 0.099300 1.65e-01 0.470000 0.35500 0.12500
Activation of GABAB receptors 22 0.287000 0.982 0.2380 1.13e-01 0.128000 1.66e-01 0.358000 0.29900 0.17900
GABA B receptor activation 22 0.287000 0.982 0.2380 1.13e-01 0.128000 1.66e-01 0.358000 0.29900 0.17900
Regulation of TP53 Activity through Phosphorylation 71 0.290000 0.982 0.1350 -9.86e-02 -0.048200 7.81e-02 0.151000 0.48300 0.25600
Protein ubiquitination 57 0.291000 0.982 0.1480 -9.96e-02 0.093400 5.76e-02 0.194000 0.22300 0.45200
Homology Directed Repair 80 0.292000 0.982 0.1260 -1.13e-01 -0.054500 -4.16e-03 0.080900 0.40000 0.94900
Ca-dependent events 30 0.292000 0.982 0.2020 9.79e-02 0.089300 1.53e-01 0.354000 0.39700 0.14700
Cell Cycle 424 0.292000 0.982 0.0550 4.97e-03 -0.054700 -3.47e-03 0.862000 0.05510 0.90300
HDMs demethylate histones 21 0.292000 0.982 0.2430 3.59e-02 -0.050900 2.35e-01 0.776000 0.68600 0.06270
Resolution of D-Loop Structures 21 0.293000 0.982 0.2450 -2.28e-01 0.022500 8.72e-02 0.071200 0.85800 0.48900
Resolution of D-loop Structures through Holliday Junction Intermediates 21 0.293000 0.982 0.2450 -2.28e-01 0.022500 8.72e-02 0.071200 0.85800 0.48900
Transport of Ribonucleoproteins into the Host Nucleus 30 0.294000 0.982 0.2060 1.61e-01 0.014300 -1.27e-01 0.127000 0.89200 0.22900
Adenylate cyclase inhibitory pathway 12 0.296000 0.982 0.3200 9.04e-02 0.260000 1.62e-01 0.588000 0.11800 0.33100
Synthesis of PE 10 0.297000 0.982 0.3470 2.54e-01 -0.141000 1.90e-01 0.165000 0.44000 0.29700
Intracellular signaling by second messengers 246 0.298000 0.982 0.0711 1.42e-02 -0.040600 5.67e-02 0.702000 0.27500 0.12700
Mitotic Metaphase and Anaphase 133 0.299000 0.982 0.0973 -6.30e-02 -0.071400 2.00e-02 0.210000 0.15600 0.69100
ERKs are inactivated 12 0.299000 0.982 0.3220 -6.96e-02 -0.258000 1.79e-01 0.677000 0.12200 0.28200
ERK/MAPK targets 20 0.300000 0.982 0.2480 1.80e-03 -0.112000 2.21e-01 0.989000 0.38600 0.08740
Negative regulation of FGFR2 signaling 21 0.301000 0.982 0.2400 2.23e-01 0.054300 7.02e-02 0.076900 0.66700 0.57800
Mitotic Spindle Checkpoint 73 0.302000 0.982 0.1290 -1.14e-01 -0.051200 -3.26e-02 0.092400 0.45000 0.63000
Retinoid metabolism and transport 23 0.303000 0.982 0.2320 1.34e-01 -0.055500 -1.81e-01 0.266000 0.64500 0.13400
Post-chaperonin tubulin folding pathway 15 0.303000 0.982 0.2830 1.13e-01 -0.222000 1.35e-01 0.449000 0.13700 0.36600
Metabolism of nucleotides 77 0.304000 0.982 0.1250 1.14e-01 -0.041200 3.12e-02 0.085100 0.53200 0.63700
Transport to the Golgi and subsequent modification 134 0.305000 0.982 0.0959 9.21e-02 -0.000099 -2.68e-02 0.066200 0.99800 0.59300
Nucleotide salvage 18 0.305000 0.982 0.2620 1.71e-01 -0.000189 -1.98e-01 0.209000 0.99900 0.14600
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 74 0.306000 0.982 0.1280 -6.27e-02 -0.087800 -6.80e-02 0.351000 0.19200 0.31200
PI3K events in ERBB2 signaling 12 0.306000 0.982 0.3160 -3.14e-01 0.012300 -3.76e-02 0.060000 0.94100 0.82200
tRNA modification in the nucleus and cytosol 30 0.307000 0.982 0.2020 -9.94e-02 -0.171000 4.10e-02 0.346000 0.10500 0.69800
Signaling by FGFR4 31 0.307000 0.982 0.1970 1.81e-01 0.070400 3.37e-02 0.081300 0.49800 0.74500
Signaling by Rho GTPases 282 0.307000 0.982 0.0654 3.36e-02 -0.000491 5.61e-02 0.334000 0.98900 0.10600
NCAM1 interactions 21 0.308000 0.982 0.2390 -1.03e-01 0.162000 1.44e-01 0.416000 0.20000 0.25400
PIP3 activates AKT signaling 212 0.309000 0.982 0.0758 3.65e-03 -0.053200 5.39e-02 0.927000 0.18300 0.17700
Reduction of cytosolic Ca++ levels 10 0.309000 0.982 0.3460 -3.56e-03 -0.028600 3.45e-01 0.984000 0.87500 0.05900
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 59 0.309000 0.982 0.1430 -1.09e-01 -0.082900 -4.01e-02 0.148000 0.27100 0.59400
Amplification of signal from the kinetochores 59 0.309000 0.982 0.1430 -1.09e-01 -0.082900 -4.01e-02 0.148000 0.27100 0.59400
CRMPs in Sema3A signaling 13 0.310000 0.982 0.3030 -1.46e-01 0.209000 1.64e-01 0.361000 0.19300 0.30500
VEGFA-VEGFR2 Pathway 78 0.310000 0.982 0.1230 1.01e-01 0.002010 7.04e-02 0.124000 0.97600 0.28300
RAF-independent MAPK1/3 activation 21 0.311000 0.982 0.2390 -1.03e-01 -0.216000 -8.32e-03 0.415000 0.08670 0.94700
TP53 Regulates Transcription of Caspase Activators and Caspases 11 0.311000 0.982 0.3270 1.61e-01 -0.271000 8.89e-02 0.355000 0.12000 0.61000
Phase 2 - plateau phase 13 0.311000 0.982 0.3000 2.41e-01 0.000434 1.78e-01 0.132000 0.99800 0.26600
PERK regulates gene expression 23 0.312000 0.982 0.2260 -2.17e-01 -0.005300 -6.51e-02 0.072000 0.96500 0.58900
mRNA decay by 5’ to 3’ exoribonuclease 13 0.312000 0.982 0.3020 -4.12e-02 -0.060700 -2.93e-01 0.797000 0.70500 0.06780
O-linked glycosylation 62 0.313000 0.982 0.1400 5.21e-02 -0.013100 -1.29e-01 0.479000 0.85900 0.07950
FGFR2 mutant receptor activation 16 0.313000 0.982 0.2720 6.88e-02 -0.172000 1.98e-01 0.634000 0.23300 0.17000
Complement cascade 19 0.313000 0.982 0.2480 -9.60e-02 -0.022300 -2.28e-01 0.469000 0.86600 0.08580
HDACs deacetylate histones 32 0.317000 0.982 0.1920 -1.36e-01 -0.125000 -5.17e-02 0.183000 0.22200 0.61300
Export of Viral Ribonucleoproteins from Nucleus 30 0.319000 0.982 0.2000 1.45e-01 0.061900 -1.24e-01 0.170000 0.55700 0.24100
NEP/NS2 Interacts with the Cellular Export Machinery 30 0.319000 0.982 0.2000 1.45e-01 0.061900 -1.24e-01 0.170000 0.55700 0.24100
Mitotic Anaphase 132 0.321000 0.982 0.0952 -6.80e-02 -0.065000 1.48e-02 0.179000 0.19800 0.77000
Regulation of pyruvate dehydrogenase (PDH) complex 15 0.322000 0.982 0.2770 1.28e-01 -0.226000 9.60e-02 0.392000 0.13000 0.52000
Lysosome Vesicle Biogenesis 26 0.322000 0.982 0.2120 -8.99e-03 -0.185000 1.04e-01 0.937000 0.10300 0.36100
Signaling by FGFR3 in disease 12 0.323000 0.982 0.3110 3.07e-01 0.038000 3.27e-02 0.065800 0.82000 0.84500
Signaling by FGFR3 point mutants in cancer 12 0.323000 0.982 0.3110 3.07e-01 0.038000 3.27e-02 0.065800 0.82000 0.84500
ER to Golgi Anterograde Transport 112 0.324000 0.982 0.1030 9.37e-02 0.010700 -4.16e-02 0.087400 0.84600 0.44800
Signaling by WNT in cancer 27 0.324000 0.982 0.2070 -1.44e-02 -0.207000 -1.82e-03 0.897000 0.06290 0.98700
Formation of HIV-1 elongation complex containing HIV-1 Tat 31 0.325000 0.982 0.1910 1.48e-01 -0.035900 1.16e-01 0.155000 0.72900 0.26400
HIV Transcription Elongation 31 0.325000 0.982 0.1910 1.48e-01 -0.035900 1.16e-01 0.155000 0.72900 0.26400
Tat-mediated elongation of the HIV-1 transcript 31 0.325000 0.982 0.1910 1.48e-01 -0.035900 1.16e-01 0.155000 0.72900 0.26400
Activation of SMO 13 0.327000 0.982 0.3010 1.53e-01 0.104000 -2.38e-01 0.340000 0.51500 0.13800
Separation of Sister Chromatids 122 0.329000 0.982 0.0981 -7.93e-02 -0.057000 8.91e-03 0.131000 0.27800 0.86500
Nucleobase biosynthesis 15 0.329000 0.982 0.2750 2.46e-01 0.052200 1.10e-01 0.099000 0.72700 0.45900
Sphingolipid metabolism 64 0.330000 0.982 0.1330 9.18e-02 0.025400 9.25e-02 0.205000 0.72500 0.20100
NS1 Mediated Effects on Host Pathways 38 0.330000 0.982 0.1750 1.58e-01 -0.019900 -7.13e-02 0.091500 0.83200 0.44700
Downstream TCR signaling 76 0.331000 0.982 0.1230 4.41e-02 -0.042200 -1.07e-01 0.507000 0.52500 0.10700
Signaling by FGFR4 in disease 11 0.331000 0.982 0.3230 2.24e-01 0.230000 3.85e-02 0.199000 0.18700 0.82500
Nephrin family interactions 17 0.332000 0.982 0.2580 -2.54e-01 0.000196 -4.56e-02 0.070000 0.99900 0.74500
Cell Cycle, Mitotic 351 0.334000 0.982 0.0575 1.13e-02 -0.055900 -7.42e-03 0.717000 0.07370 0.81200
Signaling by MET 56 0.335000 0.982 0.1420 -2.55e-02 0.111000 8.59e-02 0.742000 0.15300 0.26700
Metabolism of fat-soluble vitamins 26 0.335000 0.982 0.2100 1.18e-01 -0.085800 -1.51e-01 0.299000 0.44900 0.18300
Pre-NOTCH Expression and Processing 46 0.336000 0.982 0.1590 -1.23e-01 -0.037800 9.34e-02 0.150000 0.65700 0.27400
Retrograde transport at the Trans-Golgi-Network 44 0.337000 0.982 0.1590 1.31e-01 -0.069200 5.73e-02 0.134000 0.42700 0.51100
Trafficking of GluR2-containing AMPA receptors 12 0.337000 0.982 0.3040 1.55e-01 0.132000 2.26e-01 0.352000 0.42900 0.17600
Signaling by FGFR3 29 0.338000 0.982 0.1980 1.86e-01 0.066700 7.45e-03 0.083400 0.53400 0.94500
Beta-catenin phosphorylation cascade 16 0.339000 0.982 0.2640 7.31e-02 -0.230000 1.07e-01 0.613000 0.11100 0.46000
Transport of the SLBP Dependant Mature mRNA 33 0.340000 0.982 0.1860 1.51e-01 0.054300 -9.45e-02 0.133000 0.58900 0.34800
Transport of the SLBP independent Mature mRNA 33 0.340000 0.982 0.1860 1.51e-01 0.054300 -9.45e-02 0.133000 0.58900 0.34800
rRNA modification in the nucleus and cytosol 46 0.341000 0.982 0.1550 -6.28e-02 0.128000 -6.23e-02 0.462000 0.13500 0.46500
Translocation of SLC2A4 (GLUT4) to the plasma membrane 46 0.341000 0.982 0.1560 -2.95e-03 -0.110000 -1.10e-01 0.972000 0.19700 0.19700
G alpha (z) signalling events 30 0.342000 0.982 0.1940 1.10e-01 0.159000 1.55e-02 0.298000 0.13300 0.88300
Biological oxidations 107 0.342000 0.982 0.1040 -7.49e-02 -0.017900 6.94e-02 0.182000 0.75000 0.21600
Disease 750 0.343000 0.982 0.0399 -1.81e-02 -0.034700 8.24e-03 0.406000 0.11100 0.70400
RNA Polymerase I Transcription 46 0.343000 0.982 0.1550 3.90e-02 0.132000 7.15e-02 0.648000 0.12100 0.40200
Metabolism of vitamins and cofactors 128 0.344000 0.982 0.0935 9.24e-02 -0.012200 -6.86e-03 0.071500 0.81200 0.89400
Interconversion of nucleotide di- and triphosphates 20 0.345000 0.982 0.2360 -2.06e-01 0.053400 1.02e-01 0.110000 0.68000 0.42800
Cytosolic tRNA aminoacylation 22 0.346000 0.982 0.2240 -2.14e-02 0.016300 -2.22e-01 0.862000 0.89500 0.07140
Growth hormone receptor signaling 15 0.348000 0.982 0.2680 -1.96e-01 0.070800 -1.68e-01 0.188000 0.63500 0.26000
Signaling by FGFR1 38 0.348000 0.982 0.1700 1.64e-01 0.026000 3.45e-02 0.080000 0.78200 0.71300
Lagging Strand Synthesis 20 0.350000 0.982 0.2320 -1.62e-01 -0.061000 -1.55e-01 0.210000 0.63700 0.23200
RIP-mediated NFkB activation via ZBP1 13 0.350000 0.982 0.2920 1.57e-01 -0.109000 -2.20e-01 0.327000 0.49600 0.16900
Cyclin A/B1/B2 associated events during G2/M transition 17 0.350000 0.982 0.2520 -1.42e-01 0.164000 -1.27e-01 0.309000 0.24200 0.36600
Glucagon-type ligand receptors 14 0.352000 0.982 0.2790 1.03e-01 -0.164000 -2.02e-01 0.505000 0.28800 0.19200
Frs2-mediated activation 10 0.353000 0.982 0.3330 2.85e-01 0.034800 -1.69e-01 0.119000 0.84900 0.35400
Signaling by FGFR 60 0.353000 0.982 0.1340 1.21e-01 0.012900 5.67e-02 0.106000 0.86300 0.44800
Caspase activation via Death Receptors in the presence of ligand 13 0.353000 0.982 0.2910 5.12e-02 0.239000 -1.58e-01 0.749000 0.13600 0.32500
Regulation of IFNG signaling 11 0.356000 0.982 0.3100 -2.21e-01 0.144000 -1.64e-01 0.205000 0.41000 0.34700
Neurotransmitter receptors and postsynaptic signal transmission 103 0.357000 0.982 0.1020 6.20e-02 -0.013100 7.95e-02 0.278000 0.81800 0.16400
Interleukin-1 family signaling 103 0.357000 0.982 0.1030 8.16e-02 -0.022000 -5.96e-02 0.153000 0.70000 0.29700
Nicotinate metabolism 23 0.358000 0.982 0.2160 5.07e-02 0.187000 9.54e-02 0.674000 0.12000 0.42800
RNA Polymerase III Transcription Termination 18 0.358000 0.982 0.2440 2.35e-01 0.049900 4.19e-02 0.084000 0.71400 0.75800
Senescence-Associated Secretory Phenotype (SASP) 43 0.358000 0.982 0.1570 -1.26e-01 0.092300 -1.68e-02 0.152000 0.29500 0.84900
Deactivation of the beta-catenin transactivating complex 36 0.360000 0.982 0.1740 -1.61e-01 -0.040400 5.30e-02 0.095000 0.67500 0.58200
SLC-mediated transmembrane transport 131 0.361000 0.982 0.0909 -6.82e-02 -0.058500 -1.38e-02 0.178000 0.24800 0.78600
DAP12 interactions 21 0.362000 0.982 0.2250 -2.56e-02 0.224000 -1.25e-02 0.839000 0.07630 0.92100
Sulfur amino acid metabolism 21 0.362000 0.982 0.2270 2.13e-01 -0.024800 -7.25e-02 0.090800 0.84400 0.56600
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 16 0.363000 0.982 0.2600 -2.01e-01 -0.160000 4.00e-02 0.163000 0.26900 0.78200
Signal amplification 19 0.364000 0.982 0.2370 2.01e-01 -0.083200 -9.46e-02 0.129000 0.53000 0.47600
Transcriptional regulation of pluripotent stem cells 11 0.365000 0.982 0.3090 1.06e-01 -0.267000 1.14e-01 0.544000 0.12500 0.51300
Citric acid cycle (TCA cycle) 21 0.365000 0.982 0.2250 1.60e-01 -0.110000 -1.14e-01 0.204000 0.38500 0.36500
PPARA activates gene expression 95 0.370000 0.982 0.1060 -3.59e-02 0.065400 7.46e-02 0.546000 0.27100 0.20900
Role of phospholipids in phagocytosis 16 0.370000 0.982 0.2570 1.05e-01 -0.126000 -1.98e-01 0.469000 0.38200 0.17100
RNA Polymerase III Transcription Initiation From Type 2 Promoter 21 0.370000 0.982 0.2230 5.66e-02 0.154000 1.50e-01 0.654000 0.22100 0.23400
Transport of vitamins, nucleosides, and related molecules 25 0.373000 0.982 0.2070 -1.35e-01 -0.112000 1.09e-01 0.241000 0.33300 0.34500
PLC beta mediated events 43 0.375000 0.982 0.1540 1.23e-01 0.041100 8.38e-02 0.163000 0.64100 0.34200
PTEN Regulation 126 0.375000 0.982 0.0905 3.48e-02 -0.043500 7.14e-02 0.501000 0.40000 0.16700
ROS and RNS production in phagocytes 23 0.375000 0.982 0.2120 -1.14e-01 0.174000 3.64e-02 0.343000 0.14800 0.76300
Glyoxylate metabolism and glycine degradation 20 0.376000 0.982 0.2280 -2.60e-02 -0.036800 2.24e-01 0.841000 0.77600 0.08310
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 17 0.376000 0.982 0.2480 -2.35e-01 0.046600 6.35e-02 0.094000 0.73900 0.65000
Integrin alphaIIb beta3 signaling 20 0.378000 0.982 0.2280 -1.75e-01 0.076800 1.25e-01 0.175000 0.55200 0.33500
Integrin signaling 20 0.378000 0.982 0.2280 -1.75e-01 0.076800 1.25e-01 0.175000 0.55200 0.33500
O-linked glycosylation of mucins 29 0.379000 0.982 0.1910 1.46e-01 0.033500 -1.18e-01 0.173000 0.75500 0.27200
Unblocking of NMDA receptors, glutamate binding and activation 12 0.380000 0.982 0.2940 -2.27e-01 -0.185000 -2.26e-02 0.173000 0.26800 0.89200
Termination of O-glycan biosynthesis 13 0.380000 0.982 0.2780 -1.51e-01 0.152000 -1.78e-01 0.347000 0.34400 0.26600
Formation of TC-NER Pre-Incision Complex 44 0.380000 0.982 0.1520 2.75e-02 0.056000 1.39e-01 0.753000 0.52000 0.11100
Meiotic recombination 19 0.383000 0.982 0.2300 -2.06e-01 0.039400 -9.29e-02 0.120000 0.76600 0.48400
Downstream signaling of activated FGFR3 15 0.383000 0.982 0.2620 2.56e-01 0.006050 -5.30e-02 0.085600 0.96800 0.72300
Transcriptional regulation by RUNX3 82 0.384000 0.982 0.1120 -5.08e-02 -0.099900 7.14e-03 0.427000 0.11800 0.91100
Rev-mediated nuclear export of HIV RNA 33 0.386000 0.982 0.1770 6.36e-02 0.051300 -1.57e-01 0.528000 0.61100 0.11900
Cell-cell junction organization 24 0.386000 0.982 0.2040 1.81e-01 -0.092600 1.89e-02 0.125000 0.43200 0.87300
Interleukin-7 signaling 12 0.386000 0.982 0.2890 -3.61e-02 -0.196000 -2.10e-01 0.829000 0.24100 0.20700
Cytochrome P450 - arranged by substrate type 25 0.387000 0.982 0.1990 -1.79e-01 -0.002390 -8.87e-02 0.122000 0.98300 0.44300
WNT ligand biogenesis and trafficking 12 0.387000 0.982 0.2920 8.01e-02 -0.004900 -2.80e-01 0.631000 0.97700 0.09260
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 0.389000 0.982 0.1920 1.41e-01 0.034800 -1.25e-01 0.195000 0.75000 0.25200
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 0.389000 0.982 0.1920 1.41e-01 0.034800 -1.25e-01 0.195000 0.75000 0.25200
Removal of the Flap Intermediate 14 0.389000 0.982 0.2660 -2.38e-01 -0.026100 -1.16e-01 0.123000 0.86600 0.45400
mRNA Splicing - Major Pathway 154 0.391000 0.982 0.0810 6.46e-03 0.007650 8.03e-02 0.890000 0.87000 0.08610
Insulin receptor signalling cascade 31 0.391000 0.982 0.1800 1.68e-01 0.053300 3.56e-02 0.106000 0.60800 0.73100
Plasma lipoprotein clearance 25 0.392000 0.982 0.1980 -1.13e-01 0.122000 -1.08e-01 0.327000 0.29200 0.34800
Processive synthesis on the lagging strand 15 0.392000 0.982 0.2560 -1.86e-01 -0.076300 -1.58e-01 0.211000 0.60900 0.28800
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 97 0.393000 0.982 0.1020 -2.37e-02 0.075700 6.37e-02 0.688000 0.19800 0.27900
Cap-dependent Translation Initiation 86 0.394000 0.982 0.1080 -1.59e-03 -0.037000 1.02e-01 0.980000 0.55400 0.10400
Eukaryotic Translation Initiation 86 0.394000 0.982 0.1080 -1.59e-03 -0.037000 1.02e-01 0.980000 0.55400 0.10400
Signaling by FGFR2 IIIa TM 13 0.395000 0.982 0.2770 1.87e-02 -0.191000 1.99e-01 0.907000 0.23400 0.21300
Negative regulation of FGFR1 signaling 22 0.395000 0.982 0.2110 1.79e-01 0.063300 9.24e-02 0.146000 0.60700 0.45300
Signaling by Receptor Tyrosine Kinases 331 0.395000 0.982 0.0553 8.81e-03 -0.013600 5.29e-02 0.784000 0.67100 0.10000
Thrombin signalling through proteinase activated receptors (PARs) 18 0.399000 0.982 0.2330 2.03e-01 -0.113000 1.14e-02 0.136000 0.40600 0.93300
Downstream signaling of activated FGFR4 17 0.402000 0.982 0.2400 2.39e-01 0.019900 1.96e-03 0.087700 0.88700 0.98900
Processing and activation of SUMO 10 0.402000 0.982 0.3120 -2.66e-01 -0.129000 -1.01e-01 0.146000 0.48000 0.58200
Insulin processing 15 0.402000 0.982 0.2560 3.24e-02 0.236000 -9.56e-02 0.828000 0.11400 0.52100
Synthesis of glycosylphosphatidylinositol (GPI) 14 0.404000 0.982 0.2670 -2.16e-01 -0.003630 1.57e-01 0.162000 0.98100 0.31100
IGF1R signaling cascade 30 0.405000 0.982 0.1800 1.73e-01 0.048600 1.29e-02 0.101000 0.64500 0.90200
DNA Double-Strand Break Repair 106 0.407000 0.982 0.0968 -8.39e-02 -0.044300 1.88e-02 0.136000 0.43100 0.73900
Constitutive Signaling by EGFRvIII 15 0.409000 0.982 0.2570 1.67e-01 0.102000 -1.66e-01 0.262000 0.49300 0.26600
Signaling by EGFRvIII in Cancer 15 0.409000 0.982 0.2570 1.67e-01 0.102000 -1.66e-01 0.262000 0.49300 0.26600
Developmental Biology 570 0.410000 0.982 0.0423 -1.08e-02 -0.028200 2.97e-02 0.663000 0.25500 0.23000
Early Phase of HIV Life Cycle 13 0.411000 0.982 0.2720 1.55e-02 -0.157000 2.21e-01 0.923000 0.32600 0.16700
Ephrin signaling 15 0.411000 0.982 0.2530 -3.50e-02 -0.250000 -2.21e-02 0.815000 0.09410 0.88200
Molecules associated with elastic fibres 23 0.411000 0.982 0.2040 6.22e-02 0.161000 1.08e-01 0.606000 0.18100 0.37000
Translesion Synthesis by POLH 18 0.415000 0.982 0.2290 -1.81e-01 0.133000 4.51e-02 0.184000 0.32700 0.74000
Deadenylation of mRNA 24 0.415000 0.982 0.1970 -1.16e-01 0.044400 -1.53e-01 0.325000 0.70700 0.19500
Synthesis of PA 21 0.416000 0.982 0.2140 1.70e-01 0.129000 9.18e-03 0.177000 0.30600 0.94200
MET activates RAP1 and RAC1 10 0.416000 0.982 0.3060 -2.63e-01 0.157000 -1.41e-02 0.151000 0.38900 0.93900
Telomere C-strand (Lagging Strand) Synthesis 22 0.417000 0.982 0.2060 -9.94e-02 -0.089000 -1.57e-01 0.420000 0.47000 0.20200
Purine salvage 13 0.417000 0.982 0.2720 1.21e-01 0.016900 -2.43e-01 0.451000 0.91600 0.12900
O-glycosylation of TSR domain-containing proteins 26 0.418000 0.982 0.1890 -7.48e-02 -0.027600 -1.72e-01 0.509000 0.80700 0.13000
Resolution of Sister Chromatid Cohesion 68 0.419000 0.982 0.1190 -9.08e-02 -0.076400 6.85e-03 0.196000 0.27700 0.92200
G1/S-Specific Transcription 17 0.419000 0.982 0.2350 1.47e-01 -0.166000 -7.72e-02 0.294000 0.23500 0.58200
RNA Polymerase I Promoter Clearance 45 0.420000 0.982 0.1440 4.12e-02 0.120000 6.87e-02 0.633000 0.16300 0.42600
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 31 0.420000 0.982 0.1770 -1.28e-01 -0.082100 8.94e-02 0.217000 0.42900 0.38900
Signal transduction by L1 17 0.420000 0.982 0.2340 -1.22e-01 0.200000 1.22e-02 0.384000 0.15400 0.93100
mRNA Splicing 159 0.421000 0.982 0.0771 7.68e-03 0.006290 7.65e-02 0.868000 0.89100 0.09680
Ion homeostasis 42 0.421000 0.982 0.1490 4.25e-02 -0.119000 7.95e-02 0.634000 0.18300 0.37300
Metabolism of carbohydrates 202 0.422000 0.982 0.0692 -3.25e-02 -0.055100 2.66e-02 0.428000 0.17900 0.51600
Regulation of RUNX1 Expression and Activity 17 0.422000 0.982 0.2340 1.98e-02 -0.179000 -1.50e-01 0.888000 0.20100 0.28500
Signaling by NTRK3 (TRKC) 15 0.424000 0.982 0.2490 2.47e-01 0.025600 2.51e-02 0.098400 0.86400 0.86600
Pyruvate metabolism 26 0.424000 0.982 0.1880 1.21e-01 -0.090300 1.12e-01 0.287000 0.42600 0.32400
Interleukin-20 family signaling 13 0.424000 0.982 0.2680 -1.63e-01 -0.196000 -8.27e-02 0.309000 0.22200 0.60600
Assembly Of The HIV Virion 14 0.425000 0.982 0.2560 9.53e-02 -0.042700 2.34e-01 0.537000 0.78200 0.13000
RUNX1 regulates transcription of genes involved in differentiation of HSCs 62 0.425000 0.982 0.1220 -8.17e-02 -0.048300 -7.66e-02 0.266000 0.51100 0.29800
Peptide chain elongation 59 0.426000 0.982 0.1270 -5.86e-02 -0.017500 1.11e-01 0.436000 0.81700 0.14000
NF-kB is activated and signals survival 11 0.426000 0.982 0.2910 -1.27e-01 0.189000 1.82e-01 0.467000 0.27900 0.29700
Basigin interactions 17 0.427000 0.982 0.2320 1.06e-01 -0.052300 1.99e-01 0.451000 0.70900 0.15500
RA biosynthesis pathway 13 0.427000 0.982 0.2700 1.98e-01 0.138000 -1.21e-01 0.216000 0.38900 0.44900
GTP hydrolysis and joining of the 60S ribosomal subunit 79 0.428000 0.982 0.1090 -2.08e-03 -0.018500 1.07e-01 0.975000 0.77600 0.10000
Peroxisomal lipid metabolism 20 0.428000 0.982 0.2170 -5.53e-02 -0.134000 1.61e-01 0.669000 0.30100 0.21200
G-protein mediated events 44 0.429000 0.982 0.1440 1.07e-01 0.029000 9.14e-02 0.220000 0.74000 0.29400
IRS-related events triggered by IGF1R 29 0.429000 0.982 0.1780 1.69e-01 0.038500 4.24e-02 0.116000 0.72000 0.69300
E3 ubiquitin ligases ubiquitinate target proteins 38 0.429000 0.982 0.1560 -7.50e-02 0.114000 7.57e-02 0.424000 0.22500 0.42000
RHO GTPases activate CIT 18 0.434000 0.982 0.2240 8.86e-02 0.141000 1.50e-01 0.516000 0.30100 0.27000
Nuclear Pore Complex (NPC) Disassembly 32 0.434000 0.982 0.1710 1.44e-01 0.041300 -8.29e-02 0.160000 0.68600 0.41700
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 0.436000 0.982 0.2310 1.28e-01 -0.171000 -8.82e-02 0.361000 0.22300 0.52900
Prostacyclin signalling through prostacyclin receptor 10 0.437000 0.982 0.3000 1.63e-01 -0.250000 2.42e-02 0.371000 0.17100 0.89500
Gap junction trafficking 13 0.439000 0.982 0.2630 -2.30e-01 0.120000 4.02e-02 0.150000 0.45300 0.80200
Regulation of TNFR1 signaling 31 0.440000 0.982 0.1710 4.22e-02 0.162000 3.35e-02 0.684000 0.11800 0.74700
Vasopressin regulates renal water homeostasis via Aquaporins 30 0.441000 0.982 0.1720 1.40e-01 0.005140 9.93e-02 0.185000 0.96100 0.34700
Diseases associated with N-glycosylation of proteins 14 0.443000 0.982 0.2530 6.66e-02 -0.170000 -1.75e-01 0.666000 0.27000 0.25800
Plasma lipoprotein assembly 12 0.443000 0.982 0.2700 -1.47e-01 0.082900 -2.12e-01 0.379000 0.61900 0.20400
Vpr-mediated nuclear import of PICs 32 0.444000 0.982 0.1690 1.20e-01 0.027200 -1.16e-01 0.241000 0.79000 0.25500
Regulation of signaling by CBL 14 0.444000 0.982 0.2510 -6.41e-02 0.027600 -2.41e-01 0.678000 0.85800 0.11800
IRS-mediated signalling 26 0.444000 0.982 0.1860 1.74e-01 0.063100 1.41e-02 0.125000 0.57800 0.90100
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 29 0.446000 0.982 0.1760 -1.52e-01 0.050500 7.23e-02 0.156000 0.63800 0.50000
COPI-independent Golgi-to-ER retrograde traffic 28 0.446000 0.982 0.1800 -1.21e-01 -0.132000 1.24e-02 0.266000 0.22800 0.90900
Defective B3GALTL causes Peters-plus syndrome (PpS) 25 0.446000 0.982 0.1870 -7.06e-02 -0.058800 -1.63e-01 0.541000 0.61100 0.15800
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 0.446000 0.982 0.2730 7.78e-02 -0.074900 -2.51e-01 0.641000 0.65400 0.13300
SUMOylation of SUMOylation proteins 32 0.446000 0.982 0.1680 6.84e-02 -0.022800 -1.52e-01 0.503000 0.82400 0.13800
Formation of the cornified envelope 12 0.447000 0.982 0.2710 -1.25e-02 -0.230000 -1.44e-01 0.940000 0.16800 0.38900
p75 NTR receptor-mediated signalling 73 0.448000 0.982 0.1110 -1.73e-02 0.032200 1.04e-01 0.799000 0.63500 0.12400
TNF signaling 39 0.448000 0.982 0.1520 7.47e-02 0.118000 -6.13e-02 0.420000 0.20400 0.50800
AKT phosphorylates targets in the nucleus 10 0.449000 0.982 0.2990 -7.64e-02 0.010400 2.89e-01 0.676000 0.95500 0.11400
Dopamine Neurotransmitter Release Cycle 12 0.450000 0.982 0.2740 -1.52e-01 -0.161000 1.63e-01 0.363000 0.33500 0.32900
Kinesins 23 0.450000 0.982 0.1960 -7.07e-02 0.166000 7.64e-02 0.557000 0.17000 0.52600
Nuclear Envelope Breakdown 47 0.450000 0.982 0.1380 1.07e-01 -0.026300 -8.37e-02 0.206000 0.75500 0.32100
Vesicle-mediated transport 496 0.452000 0.982 0.0428 3.47e-02 -0.023100 -9.93e-03 0.190000 0.38300 0.70700
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 0.452000 0.982 0.2820 -2.74e-01 -0.063300 -2.73e-02 0.116000 0.71600 0.87500
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 37 0.453000 0.982 0.1530 4.02e-02 -0.038500 1.43e-01 0.673000 0.68600 0.13300
Membrane Trafficking 473 0.454000 0.982 0.0437 3.87e-02 -0.019600 -4.74e-03 0.152000 0.46900 0.86100
Complex I biogenesis 36 0.456000 0.982 0.1560 -1.51e-01 -0.032300 -1.84e-02 0.117000 0.73800 0.84900
Chaperone Mediated Autophagy 18 0.458000 0.982 0.2210 -1.79e-01 0.051400 1.19e-01 0.189000 0.70600 0.38100
Signaling by Hippo 19 0.458000 0.982 0.2130 -6.13e-02 -0.117000 -1.67e-01 0.644000 0.37900 0.20800
RNA Polymerase I Promoter Escape 26 0.459000 0.982 0.1820 -3.09e-03 0.151000 1.01e-01 0.978000 0.18200 0.37200
CLEC7A (Dectin-1) signaling 83 0.460000 0.982 0.1020 1.59e-02 -0.072500 -7.02e-02 0.802000 0.25400 0.26900
DNA Damage/Telomere Stress Induced Senescence 23 0.462000 0.982 0.1940 -1.80e-01 -0.071700 9.49e-03 0.135000 0.55200 0.93700
Ion channel transport 102 0.463000 0.982 0.0924 5.61e-02 0.073100 6.84e-03 0.328000 0.20300 0.90500
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 24 0.463000 0.982 0.1890 -2.32e-02 0.028800 1.86e-01 0.844000 0.80700 0.11500
TICAM1-dependent activation of IRF3/IRF7 11 0.463000 0.982 0.2800 5.54e-02 0.273000 -2.68e-02 0.750000 0.11700 0.87800
Peptide hormone metabolism 41 0.465000 0.982 0.1440 -2.57e-02 0.139000 2.96e-02 0.776000 0.12500 0.74300
BBSome-mediated cargo-targeting to cilium 18 0.466000 0.982 0.2180 -2.42e-02 -0.216000 7.28e-03 0.859000 0.11200 0.95700
S Phase 129 0.466000 0.982 0.0820 -6.67e-02 -0.047700 8.96e-04 0.192000 0.35100 0.98600
tRNA processing in the nucleus 50 0.469000 0.982 0.1320 9.28e-02 -0.006750 -9.29e-02 0.257000 0.93400 0.25600
Phosphorylation of CD3 and TCR zeta chains 12 0.472000 0.982 0.2660 6.55e-02 0.053400 -2.53e-01 0.694000 0.74900 0.13000
TCR signaling 90 0.472000 0.982 0.0973 4.81e-02 -0.041500 -7.37e-02 0.431000 0.49700 0.22800
Caspase-mediated cleavage of cytoskeletal proteins 11 0.473000 0.982 0.2750 -2.12e-03 -0.166000 -2.19e-01 0.990000 0.34000 0.20800
Downstream signaling of activated FGFR2 17 0.475000 0.982 0.2210 2.20e-01 0.008360 1.80e-02 0.116000 0.95200 0.89800
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 0.477000 0.982 0.2030 5.44e-02 0.119000 1.55e-01 0.674000 0.35500 0.23100
Misspliced GSK3beta mutants stabilize beta-catenin 15 0.477000 0.982 0.2340 1.17e-01 -0.193000 6.01e-02 0.433000 0.19500 0.68700
S33 mutants of beta-catenin aren’t phosphorylated 15 0.477000 0.982 0.2340 1.17e-01 -0.193000 6.01e-02 0.433000 0.19500 0.68700
S37 mutants of beta-catenin aren’t phosphorylated 15 0.477000 0.982 0.2340 1.17e-01 -0.193000 6.01e-02 0.433000 0.19500 0.68700
S45 mutants of beta-catenin aren’t phosphorylated 15 0.477000 0.982 0.2340 1.17e-01 -0.193000 6.01e-02 0.433000 0.19500 0.68700
T41 mutants of beta-catenin aren’t phosphorylated 15 0.477000 0.982 0.2340 1.17e-01 -0.193000 6.01e-02 0.433000 0.19500 0.68700
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 0.477000 0.982 0.2340 1.17e-01 -0.193000 6.01e-02 0.433000 0.19500 0.68700
Viral mRNA Translation 58 0.478000 0.982 0.1210 -5.03e-02 -0.011500 1.09e-01 0.508000 0.88000 0.15000
Negative regulation of NMDA receptor-mediated neuronal transmission 12 0.478000 0.982 0.2630 -2.41e-01 -0.097600 -3.76e-02 0.148000 0.55800 0.82200
Transport of small molecules 444 0.479000 0.982 0.0436 -2.35e-02 0.032600 -1.69e-02 0.399000 0.24300 0.54400
Signaling by FGFR2 in disease 26 0.480000 0.982 0.1760 1.11e-01 -0.043200 1.30e-01 0.326000 0.70300 0.25200
Chromatin modifying enzymes 183 0.482000 0.982 0.0674 -4.03e-02 0.045000 3.01e-02 0.349000 0.29600 0.48400
Chromatin organization 183 0.482000 0.982 0.0674 -4.03e-02 0.045000 3.01e-02 0.349000 0.29600 0.48400
HS-GAG degradation 13 0.484000 0.982 0.2520 -1.08e-01 -0.226000 2.87e-02 0.500000 0.15800 0.85800
Amino acids regulate mTORC1 40 0.484000 0.982 0.1430 -7.82e-03 0.139000 -3.36e-02 0.932000 0.12900 0.71300
Elastic fibre formation 33 0.485000 0.982 0.1560 6.94e-02 0.038500 1.34e-01 0.490000 0.70200 0.18100
Diseases of glycosylation 97 0.487000 0.982 0.0920 8.99e-03 0.014100 -9.05e-02 0.879000 0.81100 0.12400
ADP signalling through P2Y purinoceptor 12 12 0.490000 0.982 0.2610 2.44e-01 -0.018900 -8.99e-02 0.143000 0.91000 0.59000
Signaling by NODAL 11 0.491000 0.982 0.2700 -8.82e-02 -0.212000 -1.42e-01 0.612000 0.22400 0.41500
Signaling by VEGF 85 0.493000 0.982 0.0965 6.63e-02 0.023000 6.64e-02 0.292000 0.71500 0.29100
Transcriptional regulation by RUNX1 145 0.493000 0.982 0.0746 -2.32e-02 -0.063700 -3.11e-02 0.631000 0.18600 0.51900
Cleavage of the damaged purine 10 0.493000 0.982 0.2800 -2.24e-01 -0.001220 -1.68e-01 0.220000 0.99500 0.35700
Depurination 10 0.493000 0.982 0.2800 -2.24e-01 -0.001220 -1.68e-01 0.220000 0.99500 0.35700
Recognition and association of DNA glycosylase with site containing an affected purine 10 0.493000 0.982 0.2800 -2.24e-01 -0.001220 -1.68e-01 0.220000 0.99500 0.35700
Cargo concentration in the ER 23 0.495000 0.982 0.1870 1.52e-01 -0.081000 -7.27e-02 0.208000 0.50100 0.54600
Cholesterol biosynthesis 19 0.496000 0.982 0.2050 1.68e-01 -0.102000 -5.76e-02 0.205000 0.44200 0.66400
Regulation of MECP2 expression and activity 28 0.499000 0.982 0.1700 -8.91e-02 -0.117000 8.55e-02 0.414000 0.28400 0.43400
RNA Polymerase I Transcription Termination 23 0.499000 0.982 0.1860 7.52e-02 0.163000 4.76e-02 0.533000 0.17600 0.69300
N-glycan antennae elongation in the medial/trans-Golgi 17 0.499000 0.982 0.2140 1.88e-01 -0.036000 9.42e-02 0.179000 0.79700 0.50100
Depolymerisation of the Nuclear Lamina 12 0.501000 0.982 0.2570 1.43e-01 -0.150000 -1.51e-01 0.391000 0.36800 0.36400
Cell junction organization 47 0.503000 0.982 0.1290 6.42e-02 -0.111000 4.93e-03 0.447000 0.18600 0.95300
Axon guidance 378 0.503000 0.982 0.0460 8.60e-03 -0.014400 4.29e-02 0.775000 0.63300 0.15500
Degradation of beta-catenin by the destruction complex 73 0.504000 0.982 0.1040 4.29e-03 -0.094900 4.19e-02 0.950000 0.16100 0.53600
Metabolism of steroid hormones 15 0.504000 0.982 0.2270 -4.15e-02 -0.101000 -1.99e-01 0.781000 0.49800 0.18100
Formation of the Early Elongation Complex 25 0.507000 0.982 0.1750 1.58e-01 -0.012100 7.41e-02 0.172000 0.91700 0.52200
Formation of the HIV-1 Early Elongation Complex 25 0.507000 0.982 0.1750 1.58e-01 -0.012100 7.41e-02 0.172000 0.91700 0.52200
SHC1 events in ERBB4 signaling 10 0.508000 0.982 0.2780 -7.97e-02 0.217000 1.55e-01 0.662000 0.23500 0.39600
Collagen biosynthesis and modifying enzymes 44 0.508000 0.982 0.1340 4.06e-02 0.122000 -3.56e-02 0.641000 0.16100 0.68300
APC/C:Cdc20 mediated degradation of Cyclin B 19 0.508000 0.982 0.2020 -9.49e-02 0.132000 1.20e-01 0.474000 0.32000 0.36500
Glycogen breakdown (glycogenolysis) 13 0.508000 0.982 0.2450 1.64e-01 -0.131000 -1.26e-01 0.306000 0.41400 0.43200
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 34 0.509000 0.982 0.1500 9.06e-02 -0.117000 2.41e-02 0.361000 0.23800 0.80800
MAPK family signaling cascades 211 0.511000 0.982 0.0615 -2.55e-02 -0.017600 5.31e-02 0.525000 0.66100 0.18500
Interleukin-6 signaling 10 0.511000 0.982 0.2760 2.07e-01 -0.182000 -1.10e-02 0.256000 0.31900 0.95200
Degradation of GLI2 by the proteasome 51 0.513000 0.982 0.1220 6.43e-02 -0.068000 7.78e-02 0.427000 0.40100 0.33700
Caspase activation via extrinsic apoptotic signalling pathway 21 0.514000 0.982 0.1930 1.25e-01 0.030000 -1.44e-01 0.322000 0.81200 0.25300
RAB geranylgeranylation 41 0.516000 0.982 0.1370 -3.51e-02 -0.130000 -2.16e-02 0.697000 0.14900 0.81100
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 31 0.516000 0.982 0.1570 1.55e-01 0.020500 -1.74e-02 0.135000 0.84300 0.86700
Extra-nuclear estrogen signaling 56 0.516000 0.982 0.1160 1.13e-01 0.018400 2.36e-02 0.146000 0.81200 0.76000
Mitotic Telophase/Cytokinesis 10 0.517000 0.982 0.2790 -1.83e-01 -0.109000 1.81e-01 0.316000 0.55200 0.32300
Degradation of the extracellular matrix 58 0.517000 0.982 0.1150 -5.83e-02 -0.099300 -2.21e-03 0.443000 0.19100 0.97700
Telomere Maintenance 34 0.517000 0.982 0.1480 -8.98e-02 -0.049900 -1.07e-01 0.365000 0.61500 0.28100
G2/M Transition 146 0.518000 0.982 0.0718 5.87e-02 -0.035500 2.10e-02 0.222000 0.46000 0.66200
Eukaryotic Translation Elongation 62 0.519000 0.982 0.1120 -7.06e-02 -0.007870 8.64e-02 0.337000 0.91500 0.24000
Gap junction degradation 10 0.519000 0.982 0.2740 -2.25e-01 0.152000 4.06e-02 0.219000 0.40600 0.82400
Endosomal Sorting Complex Required For Transport (ESCRT) 26 0.520000 0.982 0.1690 5.42e-02 -0.072200 1.43e-01 0.633000 0.52400 0.20600
Neurotransmitter release cycle 26 0.523000 0.982 0.1690 5.36e-02 -0.145000 6.87e-02 0.636000 0.20100 0.54400
Regulation of Complement cascade 16 0.524000 0.982 0.2140 -1.14e-01 0.014000 -1.81e-01 0.431000 0.92300 0.21100
Potassium Channels 33 0.524000 0.982 0.1500 -8.30e-02 0.124000 -1.49e-02 0.409000 0.21900 0.88200
SHC1 events in ERBB2 signaling 18 0.526000 0.982 0.2040 7.36e-02 0.185000 4.40e-02 0.589000 0.17500 0.74700
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 0.527000 0.982 0.2610 -2.87e-02 -0.225000 1.28e-01 0.869000 0.19600 0.46100
Glycerophospholipid biosynthesis 83 0.528000 0.982 0.0940 4.41e-02 0.020100 8.05e-02 0.488000 0.75200 0.20500
Insulin receptor recycling 17 0.528000 0.982 0.2110 9.24e-02 0.175000 -7.12e-02 0.510000 0.21100 0.61200
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 84 0.529000 0.982 0.0937 -5.66e-02 0.072200 1.93e-02 0.370000 0.25300 0.76000
Nonsense-Mediated Decay (NMD) 84 0.529000 0.982 0.0937 -5.66e-02 0.072200 1.93e-02 0.370000 0.25300 0.76000
Association of TriC/CCT with target proteins during biosynthesis 32 0.530000 0.982 0.1530 -9.75e-02 -0.113000 3.35e-02 0.340000 0.26700 0.74300
Diseases associated with O-glycosylation of proteins 41 0.531000 0.982 0.1330 -5.44e-02 0.047300 -1.12e-01 0.547000 0.60000 0.21500
Interleukin-12 signaling 30 0.533000 0.982 0.1570 -2.74e-02 -0.012800 1.54e-01 0.795000 0.90300 0.14500
Nicotinamide salvaging 12 0.534000 0.982 0.2460 -7.29e-03 0.228000 9.35e-02 0.965000 0.17200 0.57500
Deubiquitination 209 0.535000 0.982 0.0597 -4.58e-02 0.022500 3.11e-02 0.255000 0.57600 0.44000
Factors involved in megakaryocyte development and platelet production 84 0.536000 0.982 0.0930 -2.38e-02 0.080200 -4.07e-02 0.707000 0.20500 0.51900
Carboxyterminal post-translational modifications of tubulin 22 0.537000 0.982 0.1810 -2.79e-02 -0.148000 -1.01e-01 0.821000 0.23000 0.41200
RUNX2 regulates osteoblast differentiation 20 0.538000 0.982 0.1900 -2.57e-02 0.172000 -7.62e-02 0.843000 0.18200 0.55500
Recycling pathway of L1 22 0.538000 0.982 0.1800 7.09e-02 0.002620 1.65e-01 0.565000 0.98300 0.17900
Signaling by NTRK1 (TRKA) 69 0.539000 0.982 0.1010 8.30e-02 -0.031800 4.90e-02 0.234000 0.64800 0.48200
Synaptic adhesion-like molecules 11 0.540000 0.982 0.2590 -1.61e-01 -0.146000 1.41e-01 0.354000 0.40200 0.41900
Transport of Mature mRNA Derived from an Intronless Transcript 40 0.540000 0.982 0.1360 6.81e-02 0.106000 -5.06e-02 0.457000 0.24700 0.58000
Transport of Mature mRNAs Derived from Intronless Transcripts 40 0.540000 0.982 0.1360 6.81e-02 0.106000 -5.06e-02 0.457000 0.24700 0.58000
Assembly of active LPL and LIPC lipase complexes 10 0.542000 0.982 0.2650 -1.63e-01 0.090900 -1.88e-01 0.372000 0.61900 0.30400
Signaling by BMP 24 0.543000 0.982 0.1720 4.28e-02 -0.167000 5.28e-03 0.716000 0.15700 0.96400
Repression of WNT target genes 12 0.545000 0.982 0.2440 -2.24e-01 -0.096800 -1.31e-02 0.179000 0.56200 0.93700
Protein-protein interactions at synapses 46 0.546000 0.982 0.1230 1.09e-01 -0.036000 4.60e-02 0.203000 0.67300 0.59000
G0 and Early G1 17 0.546000 0.982 0.2040 -1.37e-02 -0.181000 -9.36e-02 0.922000 0.19700 0.50400
Uptake and actions of bacterial toxins 22 0.546000 0.982 0.1810 -4.55e-02 -0.149000 9.16e-02 0.712000 0.22600 0.45700
Signaling by NTRKs 83 0.547000 0.982 0.0917 5.69e-02 -0.038500 6.07e-02 0.371000 0.54400 0.33900
Host Interactions with Influenza Factors 40 0.548000 0.982 0.1340 1.16e-01 -0.009400 -6.74e-02 0.206000 0.91800 0.46100
Mitotic G2-G2/M phases 147 0.549000 0.982 0.0690 5.79e-02 -0.032800 1.83e-02 0.226000 0.49400 0.70200
Mitotic G1-G1/S phases 114 0.550000 0.982 0.0788 7.00e-03 -0.071200 -3.29e-02 0.897000 0.19000 0.54500
Protein folding 71 0.550000 0.982 0.0993 4.13e-02 -0.088700 1.71e-02 0.547000 0.19700 0.80300
Defective B3GAT3 causes JDSSDHD 12 0.550000 0.982 0.2400 1.57e-01 -0.177000 4.13e-02 0.345000 0.28900 0.80400
RNA Polymerase II Transcription Termination 53 0.550000 0.982 0.1150 2.82e-02 0.101000 4.77e-02 0.723000 0.20400 0.54800
Intraflagellar transport 33 0.551000 0.982 0.1450 6.23e-02 0.098000 8.76e-02 0.536000 0.33000 0.38400
Glutamate binding, activation of AMPA receptors and synaptic plasticity 22 0.552000 0.982 0.1770 1.15e-01 0.085100 1.05e-01 0.349000 0.49000 0.39600
Trafficking of AMPA receptors 22 0.552000 0.982 0.1770 1.15e-01 0.085100 1.05e-01 0.349000 0.49000 0.39600
Signaling by Interleukins 291 0.554000 0.982 0.0492 1.71e-02 -0.028800 3.61e-02 0.618000 0.40000 0.29200
Removal of the Flap Intermediate from the C-strand 10 0.555000 0.982 0.2650 -2.42e-01 -0.107000 3.42e-03 0.184000 0.55900 0.98500
Eukaryotic Translation Termination 62 0.555000 0.982 0.1070 -4.60e-02 0.013700 9.55e-02 0.532000 0.85200 0.19400
Signaling by FGFR2 51 0.556000 0.982 0.1160 1.03e-01 0.003550 5.28e-02 0.203000 0.96500 0.51500
Negative regulation of the PI3K/AKT network 73 0.557000 0.982 0.0985 -3.53e-02 -0.031200 8.65e-02 0.603000 0.64500 0.20200
TP53 Regulates Transcription of Cell Death Genes 36 0.560000 0.982 0.1380 1.30e-01 -0.044200 9.72e-03 0.177000 0.64600 0.92000
PCNA-Dependent Long Patch Base Excision Repair 18 0.560000 0.982 0.1950 2.51e-02 -0.155000 -1.16e-01 0.854000 0.25500 0.39500
Calnexin/calreticulin cycle 23 0.561000 0.982 0.1730 -3.38e-02 0.147000 8.44e-02 0.779000 0.22400 0.48400
Glycogen synthesis 13 0.563000 0.982 0.2280 -2.09e-01 0.091100 -1.52e-03 0.192000 0.57000 0.99200
M Phase 248 0.564000 0.982 0.0526 2.11e-02 -0.047600 7.77e-03 0.568000 0.19900 0.83400
Processive synthesis on the C-strand of the telomere 11 0.564000 0.982 0.2490 -1.71e-01 -0.168000 -6.59e-02 0.325000 0.33500 0.70500
Vitamin B5 (pantothenate) metabolism 13 0.566000 0.982 0.2280 4.92e-02 -0.141000 1.72e-01 0.759000 0.38000 0.28200
TNFR1-induced proapoptotic signaling 12 0.566000 0.982 0.2370 1.00e-02 0.216000 9.78e-02 0.952000 0.19500 0.55700
Diseases of metabolism 64 0.567000 0.982 0.1040 -4.53e-02 0.031800 8.75e-02 0.531000 0.66100 0.22600
Transcription of E2F targets under negative control by DREAM complex 15 0.568000 0.982 0.2120 1.04e-01 -0.137000 -1.25e-01 0.488000 0.35900 0.40200
Death Receptor Signalling 114 0.568000 0.982 0.0773 2.66e-02 0.070800 1.57e-02 0.624000 0.19200 0.77300
HIV Life Cycle 123 0.571000 0.982 0.0736 7.02e-02 -0.010000 1.99e-02 0.180000 0.84800 0.70400
Regulation of TP53 Degradation 28 0.572000 0.982 0.1550 -4.88e-02 0.014100 1.47e-01 0.655000 0.89700 0.17900
Regulation of TP53 Expression and Degradation 28 0.572000 0.982 0.1550 -4.88e-02 0.014100 1.47e-01 0.655000 0.89700 0.17900
RAF/MAP kinase cascade 174 0.573000 0.982 0.0631 -4.34e-02 -0.021600 4.04e-02 0.325000 0.62400 0.35900
Recognition of DNA damage by PCNA-containing replication complex 27 0.573000 0.982 0.1590 -1.07e-01 -0.081200 8.55e-02 0.336000 0.46600 0.44200
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 67 0.574000 0.982 0.1000 -1.84e-02 -0.033300 9.29e-02 0.794000 0.63800 0.18900
SUMOylation of DNA replication proteins 39 0.574000 0.982 0.1320 7.25e-02 0.026300 -1.07e-01 0.434000 0.77600 0.24600
SUMOylation of RNA binding proteins 45 0.574000 0.982 0.1220 7.18e-02 -0.084100 -5.05e-02 0.405000 0.33000 0.55800
Regulation of RUNX2 expression and activity 59 0.575000 0.982 0.1060 5.40e-03 0.029500 1.02e-01 0.943000 0.69500 0.17700
Other semaphorin interactions 15 0.576000 0.982 0.2110 -1.12e-01 -0.179000 -5.65e-03 0.453000 0.23100 0.97000
Negative epigenetic regulation of rRNA expression 42 0.577000 0.982 0.1270 9.91e-02 -0.014900 -7.72e-02 0.267000 0.86800 0.38700
GAB1 signalosome 13 0.578000 0.982 0.2230 -1.82e-01 0.055500 -1.15e-01 0.256000 0.72900 0.47100
AMER1 mutants destabilize the destruction complex 14 0.580000 0.982 0.2150 9.41e-02 -0.194000 -2.33e-03 0.542000 0.20900 0.98800
APC truncation mutants have impaired AXIN binding 14 0.580000 0.982 0.2150 9.41e-02 -0.194000 -2.33e-03 0.542000 0.20900 0.98800
AXIN missense mutants destabilize the destruction complex 14 0.580000 0.982 0.2150 9.41e-02 -0.194000 -2.33e-03 0.542000 0.20900 0.98800
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 0.580000 0.982 0.2150 9.41e-02 -0.194000 -2.33e-03 0.542000 0.20900 0.98800
Truncations of AMER1 destabilize the destruction complex 14 0.580000 0.982 0.2150 9.41e-02 -0.194000 -2.33e-03 0.542000 0.20900 0.98800
truncated APC mutants destabilize the destruction complex 14 0.580000 0.982 0.2150 9.41e-02 -0.194000 -2.33e-03 0.542000 0.20900 0.98800
Regulation of FZD by ubiquitination 14 0.582000 0.982 0.2140 -1.80e-01 0.065500 -9.41e-02 0.243000 0.67100 0.54200
VEGFR2 mediated vascular permeability 21 0.583000 0.982 0.1750 1.42e-01 -0.097000 2.91e-02 0.259000 0.44200 0.81700
FCERI mediated NF-kB activation 67 0.585000 0.982 0.0984 9.84e-03 -0.078800 -5.81e-02 0.889000 0.26500 0.41100
Signal Transduction 1457 0.585000 0.982 0.0225 -3.97e-03 -0.014000 1.71e-02 0.805000 0.38200 0.28600
TP53 Regulates Transcription of Death Receptors and Ligands 10 0.586000 0.982 0.2530 2.14e-01 0.067800 1.16e-01 0.241000 0.71000 0.52700
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 0.586000 0.982 0.1590 7.77e-02 -0.096600 1.00e-01 0.502000 0.40400 0.38500
Defects in vitamin and cofactor metabolism 18 0.586000 0.982 0.1880 1.67e-01 0.035300 7.99e-02 0.221000 0.79600 0.55800
RAB GEFs exchange GTP for GDP on RABs 76 0.586000 0.982 0.0918 6.24e-02 -0.066900 6.91e-03 0.348000 0.31400 0.91700
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 0.588000 0.982 0.2440 1.91e-01 0.014700 -1.52e-01 0.274000 0.93300 0.38200
Cytosolic sensors of pathogen-associated DNA 48 0.589000 0.982 0.1170 8.44e-02 0.079200 -1.32e-02 0.312000 0.34300 0.87500
Nuclear import of Rev protein 32 0.590000 0.982 0.1430 1.29e-01 0.012100 -6.06e-02 0.208000 0.90600 0.55300
Effects of PIP2 hydrolysis 20 0.590000 0.982 0.1800 1.58e-01 -0.019600 -8.48e-02 0.222000 0.87900 0.51200
Interleukin-6 family signaling 18 0.590000 0.982 0.1880 6.49e-02 -0.164000 6.51e-02 0.634000 0.23000 0.63300
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 0.590000 0.982 0.1670 -1.04e-01 -0.129000 -2.36e-02 0.390000 0.28400 0.84500
Prolonged ERK activation events 12 0.591000 0.982 0.2340 1.78e-01 0.090600 -1.21e-01 0.285000 0.58700 0.47000
Formation of RNA Pol II elongation complex 43 0.591000 0.982 0.1210 1.05e-01 0.017500 5.84e-02 0.236000 0.84300 0.50800
RNA Polymerase II Transcription Elongation 43 0.591000 0.982 0.1210 1.05e-01 0.017500 5.84e-02 0.236000 0.84300 0.50800
Formation of a pool of free 40S subunits 69 0.592000 0.982 0.0968 -2.61e-02 0.003710 9.31e-02 0.708000 0.95800 0.18200
MAPK1/MAPK3 signaling 179 0.592000 0.982 0.0607 -3.03e-02 -0.029000 4.39e-02 0.486000 0.50500 0.31300
Triglyceride metabolism 23 0.594000 0.982 0.1680 -7.38e-02 -0.107000 1.06e-01 0.540000 0.37500 0.37800
RET signaling 27 0.595000 0.982 0.1550 1.28e-01 0.020000 -8.45e-02 0.249000 0.85700 0.44700
Gamma carboxylation, hypusine formation and arylsulfatase activation 27 0.595000 0.982 0.1540 -1.20e-01 -0.096500 1.17e-02 0.283000 0.38600 0.91600
Dual Incision in GG-NER 36 0.596000 0.982 0.1330 -3.77e-02 0.010900 1.27e-01 0.696000 0.91000 0.18700
MHC class II antigen presentation 75 0.601000 0.982 0.0924 6.57e-02 0.013900 -6.33e-02 0.325000 0.83500 0.34300
Regulation of necroptotic cell death 13 0.603000 0.982 0.2200 8.72e-02 0.127000 -1.58e-01 0.586000 0.43000 0.32400
SUMOylation of chromatin organization proteins 55 0.603000 0.982 0.1060 2.30e-02 -0.103000 -1.42e-02 0.769000 0.18900 0.85600
HIV Infection 187 0.604000 0.982 0.0575 2.59e-02 -0.042600 2.86e-02 0.543000 0.31600 0.50100
N-Glycan antennae elongation 11 0.604000 0.982 0.2360 2.26e-01 0.051000 4.90e-02 0.195000 0.77000 0.77800
Heparan sulfate/heparin (HS-GAG) metabolism 31 0.605000 0.982 0.1420 -2.91e-02 -0.138000 6.25e-03 0.779000 0.18300 0.95200
PKMTs methylate histone lysines 35 0.609000 0.982 0.1330 -3.82e-02 0.035200 1.22e-01 0.696000 0.71800 0.21200
TGF-beta receptor signaling activates SMADs 30 0.610000 0.982 0.1430 -3.34e-02 -0.133000 3.96e-02 0.752000 0.20600 0.70700
PD-1 signaling 13 0.611000 0.982 0.2160 -1.12e-02 0.034900 -2.13e-01 0.944000 0.82700 0.18400
Respiratory electron transport 70 0.612000 0.982 0.0927 -4.65e-02 -0.059100 -5.42e-02 0.502000 0.39300 0.43300
Regulation of IFNA signaling 10 0.613000 0.982 0.2460 2.96e-02 0.242000 -3.62e-02 0.871000 0.18600 0.84300
HIV Transcription Initiation 34 0.614000 0.982 0.1330 -1.28e-02 0.127000 3.63e-02 0.897000 0.19900 0.71500
RNA Polymerase II HIV Promoter Escape 34 0.614000 0.982 0.1330 -1.28e-02 0.127000 3.63e-02 0.897000 0.19900 0.71500
RNA Polymerase II Promoter Escape 34 0.614000 0.982 0.1330 -1.28e-02 0.127000 3.63e-02 0.897000 0.19900 0.71500
RNA Polymerase II Transcription Initiation 34 0.614000 0.982 0.1330 -1.28e-02 0.127000 3.63e-02 0.897000 0.19900 0.71500
RNA Polymerase II Transcription Initiation And Promoter Clearance 34 0.614000 0.982 0.1330 -1.28e-02 0.127000 3.63e-02 0.897000 0.19900 0.71500
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 34 0.614000 0.982 0.1330 -1.28e-02 0.127000 3.63e-02 0.897000 0.19900 0.71500
Late Phase of HIV Life Cycle 111 0.618000 0.982 0.0736 7.30e-02 0.007850 4.74e-03 0.185000 0.88700 0.93100
RNA Polymerase III Chain Elongation 13 0.620000 0.982 0.2120 1.26e-01 0.108000 1.32e-01 0.431000 0.49900 0.41000
Cellular responses to external stimuli 333 0.621000 0.982 0.0425 -1.36e-02 0.032100 -2.43e-02 0.672000 0.31600 0.44900
Rap1 signalling 13 0.624000 0.982 0.2140 -1.92e-01 0.008410 9.36e-02 0.230000 0.95800 0.55900
Innate Immune System 639 0.624000 0.982 0.0308 2.57e-02 0.005730 1.59e-02 0.272000 0.80700 0.49600
Adrenaline,noradrenaline inhibits insulin secretion 18 0.624000 0.982 0.1820 1.55e-01 0.091400 -2.81e-02 0.256000 0.50200 0.83700
Platelet sensitization by LDL 15 0.624000 0.982 0.1980 8.82e-04 -0.196000 2.40e-02 0.995000 0.18800 0.87200
Transcription of the HIV genome 52 0.625000 0.982 0.1050 7.80e-02 0.024400 6.64e-02 0.331000 0.76100 0.40800
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 14 0.626000 0.982 0.2050 6.30e-02 0.187000 -5.76e-02 0.683000 0.22600 0.70900
Keratan sulfate/keratin metabolism 22 0.627000 0.982 0.1640 -1.42e-01 -0.071800 3.98e-02 0.248000 0.56000 0.74700
TBC/RABGAPs 38 0.627000 0.982 0.1250 -1.14e-01 -0.011600 4.92e-02 0.223000 0.90100 0.60000
Regulation of innate immune responses to cytosolic DNA 11 0.628000 0.982 0.2280 -1.38e-01 0.180000 -2.10e-02 0.428000 0.30000 0.90400
Signaling by NTRK2 (TRKB) 19 0.629000 0.982 0.1760 7.05e-02 0.157000 -3.56e-02 0.595000 0.23600 0.78800
Degradation of cysteine and homocysteine 11 0.631000 0.982 0.2310 2.11e-01 0.008880 -9.33e-02 0.226000 0.95900 0.59200
Transport of bile salts and organic acids, metal ions and amine compounds 32 0.633000 0.982 0.1330 -7.30e-02 -0.026100 -1.08e-01 0.475000 0.79800 0.29200
Semaphorin interactions 55 0.634000 0.982 0.1030 -7.10e-02 0.016100 7.29e-02 0.363000 0.83700 0.35000
Purine ribonucleoside monophosphate biosynthesis 12 0.634000 0.982 0.2170 1.85e-01 0.080000 8.21e-02 0.268000 0.63100 0.62200
Post-translational protein modification 1009 0.635000 0.982 0.0249 -2.01e-02 -0.014500 2.22e-03 0.288000 0.44300 0.90700
TNFR1-induced NFkappaB signaling pathway 24 0.635000 0.982 0.1550 1.06e-01 -0.080000 -7.87e-02 0.368000 0.49800 0.50400
Endogenous sterols 17 0.637000 0.982 0.1810 -1.31e-01 0.021100 -1.23e-01 0.351000 0.88100 0.38000
Cyclin D associated events in G1 38 0.638000 0.982 0.1230 3.83e-02 -0.023400 -1.14e-01 0.683000 0.80300 0.22300
G1 Phase 38 0.638000 0.982 0.1230 3.83e-02 -0.023400 -1.14e-01 0.683000 0.80300 0.22300
Chemokine receptors bind chemokines 12 0.640000 0.982 0.2160 -1.20e-01 0.177000 3.06e-02 0.472000 0.28900 0.85400
Sialic acid metabolism 26 0.642000 0.982 0.1470 1.45e-01 0.007590 -2.63e-02 0.201000 0.94700 0.81700
Post-translational protein phosphorylation 64 0.642000 0.982 0.0945 8.56e-02 0.005360 -3.97e-02 0.237000 0.94100 0.58300
Interactions of Rev with host cellular proteins 35 0.643000 0.982 0.1280 6.14e-02 0.025700 -1.09e-01 0.530000 0.79200 0.26400
DCC mediated attractive signaling 12 0.643000 0.982 0.2140 -1.51e-01 0.148000 -3.57e-02 0.367000 0.37500 0.83100
TNFR2 non-canonical NF-kB pathway 62 0.645000 0.982 0.0944 6.19e-02 -0.070900 -8.00e-03 0.400000 0.33500 0.91300
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 27 0.646000 0.982 0.1420 1.27e-01 -0.060800 1.90e-02 0.252000 0.58500 0.86400
TP53 Regulates Metabolic Genes 70 0.646000 0.982 0.0887 4.82e-02 -0.074400 3.38e-03 0.486000 0.28300 0.96100
IRAK1 recruits IKK complex 10 0.648000 0.982 0.2340 2.12e-01 -0.098800 -7.41e-03 0.246000 0.58900 0.96800
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 0.648000 0.982 0.2340 2.12e-01 -0.098800 -7.41e-03 0.246000 0.58900 0.96800
Signaling by Hedgehog 114 0.648000 0.982 0.0692 6.34e-02 -0.022600 1.62e-02 0.243000 0.67700 0.76600
Arachidonic acid metabolism 23 0.649000 0.982 0.1530 -1.26e-01 0.066200 -5.76e-02 0.297000 0.58300 0.63300
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 0.650000 0.982 0.2220 1.45e-01 -0.158000 5.66e-02 0.406000 0.36500 0.74500
Listeria monocytogenes entry into host cells 16 0.650000 0.982 0.1840 5.82e-02 -0.016200 1.74e-01 0.687000 0.91100 0.22900
Interleukin-4 and Interleukin-13 signaling 63 0.651000 0.982 0.0944 -6.75e-02 -0.044600 4.88e-02 0.355000 0.54100 0.50400
VLDLR internalisation and degradation 11 0.652000 0.982 0.2240 -1.81e-01 0.061900 1.17e-01 0.300000 0.72200 0.50200
FCERI mediated Ca+2 mobilization 21 0.653000 0.982 0.1610 -1.10e-01 -0.114000 -2.94e-02 0.383000 0.36600 0.81600
Synthesis of PIPs at the early endosome membrane 16 0.654000 0.982 0.1830 4.22e-02 0.098800 1.48e-01 0.770000 0.49400 0.30500
Biotin transport and metabolism 10 0.654000 0.982 0.2310 1.25e-01 0.040900 1.89e-01 0.492000 0.82300 0.30100
SHC1 events in EGFR signaling 10 0.655000 0.982 0.2320 1.36e-01 0.172000 7.84e-02 0.457000 0.34800 0.66800
GPVI-mediated activation cascade 19 0.655000 0.982 0.1690 4.71e-03 0.149000 -7.93e-02 0.972000 0.26000 0.55000
Cellular responses to stress 328 0.655000 0.982 0.0410 -8.31e-03 0.035200 -1.94e-02 0.797000 0.27600 0.54700
C-type lectin receptors (CLRs) 102 0.656000 0.982 0.0728 -3.20e-03 -0.069000 -2.29e-02 0.956000 0.22900 0.68900
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 0.657000 0.982 0.2110 1.47e-02 -0.148000 -1.50e-01 0.930000 0.37400 0.36900
Pre-NOTCH Transcription and Translation 33 0.658000 0.982 0.1280 -1.24e-01 -0.022600 2.31e-02 0.218000 0.82200 0.81900
L13a-mediated translational silencing of Ceruloplasmin expression 78 0.658000 0.982 0.0833 -1.25e-02 0.006730 8.20e-02 0.849000 0.91800 0.21100
RMTs methylate histone arginines 27 0.660000 0.982 0.1410 5.67e-02 0.129000 -1.26e-02 0.610000 0.24700 0.91000
Membrane binding and targetting of GAG proteins 12 0.661000 0.982 0.2080 1.51e-01 -0.018800 1.42e-01 0.365000 0.91000 0.39400
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 0.661000 0.982 0.2080 1.51e-01 -0.018800 1.42e-01 0.365000 0.91000 0.39400
CD209 (DC-SIGN) signaling 16 0.661000 0.982 0.1830 -6.03e-02 0.021500 1.72e-01 0.676000 0.88200 0.23400
Erythropoietin activates RAS 12 0.662000 0.982 0.2110 9.13e-02 -0.105000 -1.58e-01 0.584000 0.52900 0.34300
DAG and IP3 signaling 35 0.665000 0.982 0.1210 8.02e-02 0.009070 9.08e-02 0.412000 0.92600 0.35300
NRIF signals cell death from the nucleus 12 0.665000 0.982 0.2090 -1.30e-01 0.158000 3.98e-02 0.435000 0.34300 0.81200
Mitochondrial protein import 44 0.665000 0.982 0.1090 -1.09e-01 -0.000955 -6.45e-03 0.211000 0.99100 0.94100
HSP90 chaperone cycle for steroid hormone receptors (SHR) 31 0.665000 0.982 0.1300 -1.38e-02 0.093900 -8.91e-02 0.894000 0.36600 0.39100
Transcriptional regulation of white adipocyte differentiation 68 0.665000 0.982 0.0889 -7.44e-02 -0.043900 2.07e-02 0.289000 0.53200 0.76800
Costimulation by the CD28 family 45 0.667000 0.982 0.1080 -2.69e-03 -0.099300 -4.17e-02 0.975000 0.25000 0.62900
Leading Strand Synthesis 14 0.668000 0.982 0.1920 -7.33e-02 -0.015900 -1.76e-01 0.635000 0.91800 0.25400
Polymerase switching 14 0.668000 0.982 0.1920 -7.33e-02 -0.015900 -1.76e-01 0.635000 0.91800 0.25400
Polymerase switching on the C-strand of the telomere 14 0.668000 0.982 0.1920 -7.33e-02 -0.015900 -1.76e-01 0.635000 0.91800 0.25400
Mismatch Repair 13 0.668000 0.982 0.2000 3.47e-02 -0.084600 -1.78e-01 0.828000 0.59700 0.26600
Activation of RAC1 10 0.669000 0.982 0.2270 7.11e-02 -0.103000 1.89e-01 0.697000 0.57300 0.30000
Chromosome Maintenance 49 0.669000 0.982 0.1030 -5.72e-02 -0.057800 -6.25e-02 0.489000 0.48500 0.44900
Nuclear Receptor transcription pathway 41 0.670000 0.982 0.1130 -4.87e-02 0.067700 7.57e-02 0.590000 0.45300 0.40200
Transcriptional regulation of granulopoiesis 25 0.671000 0.982 0.1440 -4.35e-02 -0.135000 -2.41e-02 0.707000 0.24200 0.83500
Thromboxane signalling through TP receptor 13 0.671000 0.982 0.1990 1.56e-01 -0.118000 -3.38e-02 0.330000 0.46100 0.83300
Phase I - Functionalization of compounds 55 0.672000 0.982 0.0973 -4.70e-02 -0.084900 -6.96e-03 0.547000 0.27600 0.92900
Processing of Capped Intron-Containing Pre-mRNA 203 0.673000 0.982 0.0504 1.35e-02 0.020000 4.42e-02 0.740000 0.62400 0.27900
Inflammasomes 14 0.675000 0.982 0.1910 -6.42e-02 0.173000 4.79e-02 0.678000 0.26300 0.75600
Hyaluronan metabolism 11 0.676000 0.982 0.2160 -1.28e-01 0.090800 1.49e-01 0.463000 0.60200 0.39300
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 21 0.677000 0.982 0.1550 9.77e-02 -0.118000 2.08e-02 0.439000 0.35000 0.86900
Interleukin-15 signaling 11 0.677000 0.982 0.2170 1.09e-01 0.176000 -6.36e-02 0.532000 0.31200 0.71500
Retrograde neurotrophin signalling 10 0.678000 0.982 0.2260 -9.32e-02 0.070800 1.94e-01 0.610000 0.69800 0.28900
Mitochondrial biogenesis 67 0.679000 0.982 0.0879 -5.95e-02 0.003720 6.46e-02 0.400000 0.95800 0.36100
Activation of G protein gated Potassium channels 10 0.679000 0.982 0.2220 1.40e-01 -0.031300 1.70e-01 0.442000 0.86400 0.35300
G protein gated Potassium channels 10 0.679000 0.982 0.2220 1.40e-01 -0.031300 1.70e-01 0.442000 0.86400 0.35300
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 10 0.679000 0.982 0.2220 1.40e-01 -0.031300 1.70e-01 0.442000 0.86400 0.35300
Keratinization 13 0.681000 0.982 0.1960 -5.48e-02 -0.161000 -9.83e-02 0.732000 0.31600 0.54000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 25 0.681000 0.982 0.1410 3.91e-02 -0.136000 8.79e-03 0.735000 0.24100 0.93900
PI-3K cascade:FGFR4 10 0.681000 0.982 0.2260 2.08e-01 0.000402 -8.70e-02 0.254000 0.99800 0.63400
Spry regulation of FGF signaling 16 0.682000 0.982 0.1780 1.29e-01 0.121000 -2.67e-02 0.373000 0.40400 0.85300
Diseases associated with glycosaminoglycan metabolism 27 0.683000 0.982 0.1370 -9.30e-02 0.033600 9.49e-02 0.403000 0.76300 0.39400
RORA activates gene expression 17 0.683000 0.982 0.1720 -1.61e-01 -0.059400 5.53e-03 0.249000 0.67200 0.96900
Signaling by ROBO receptors 159 0.684000 0.982 0.0559 1.91e-02 -0.023100 4.72e-02 0.678000 0.61600 0.30600
Hedgehog ‘on’ state 71 0.685000 0.982 0.0837 3.57e-02 -0.067300 -3.46e-02 0.604000 0.32700 0.61500
Nuclear signaling by ERBB4 21 0.686000 0.982 0.1530 -1.37e-01 -0.058600 -3.65e-02 0.277000 0.64200 0.77200
Major pathway of rRNA processing in the nucleolus and cytosol 129 0.686000 0.982 0.0616 -4.99e-02 0.022200 -2.84e-02 0.329000 0.66300 0.57900
Degradation of DVL 48 0.687000 0.982 0.1010 1.54e-02 -0.099200 1.45e-02 0.853000 0.23500 0.86200
Metabolism of nitric oxide: eNOS activation and regulation 14 0.687000 0.982 0.1870 5.97e-02 -0.177000 -1.68e-02 0.699000 0.25300 0.91300
Ribosomal scanning and start codon recognition 43 0.689000 0.982 0.1060 3.77e-02 -0.007290 9.91e-02 0.669000 0.93400 0.26100
EPHA-mediated growth cone collapse 14 0.689000 0.982 0.1860 7.97e-02 0.065400 1.55e-01 0.606000 0.67200 0.31600
Josephin domain DUBs 11 0.689000 0.982 0.2110 -3.86e-02 0.133000 1.59e-01 0.824000 0.44500 0.36100
Metabolism 1392 0.690000 0.982 0.0197 9.67e-03 -0.016500 4.78e-03 0.555000 0.31400 0.77000
Microautophagy 26 0.690000 0.982 0.1370 1.44e-02 -0.019200 1.35e-01 0.899000 0.86600 0.23400
Negative regulation of MET activity 18 0.691000 0.982 0.1640 -4.11e-02 0.126000 9.69e-02 0.763000 0.35400 0.47700
Transport of inorganic cations/anions and amino acids/oligopeptides 65 0.692000 0.982 0.0863 -2.40e-02 -0.049000 -6.69e-02 0.739000 0.49500 0.35200
Regulation of ornithine decarboxylase (ODC) 40 0.694000 0.982 0.1100 3.80e-02 -0.101000 -2.16e-02 0.678000 0.27000 0.81300
Cytochrome c-mediated apoptotic response 13 0.694000 0.982 0.1920 1.90e-01 -0.014300 2.27e-02 0.235000 0.92900 0.88700
Interaction between L1 and Ankyrins 16 0.695000 0.982 0.1750 1.20e-01 -0.056300 -1.14e-01 0.405000 0.69700 0.43200
Interactions of Vpr with host cellular proteins 34 0.696000 0.982 0.1200 9.14e-02 0.020100 -7.57e-02 0.357000 0.83900 0.44500
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 15 0.698000 0.982 0.1800 -3.33e-02 -0.156000 8.23e-02 0.823000 0.29600 0.58100
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 22 0.698000 0.982 0.1470 9.51e-02 0.068900 8.76e-02 0.440000 0.57600 0.47700
The NLRP3 inflammasome 10 0.700000 0.982 0.2160 -9.75e-02 0.131000 -1.42e-01 0.593000 0.47200 0.43800
Circadian Clock 62 0.700000 0.982 0.0888 -5.40e-02 -0.019200 6.78e-02 0.463000 0.79400 0.35600
RNA Polymerase II Pre-transcription Events 60 0.701000 0.982 0.0886 7.42e-02 0.035500 3.29e-02 0.321000 0.63500 0.65900
Extracellular matrix organization 189 0.702000 0.982 0.0499 4.41e-02 -0.013000 1.94e-02 0.298000 0.75900 0.64600
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 0.702000 0.982 0.1590 8.52e-02 0.130000 -3.08e-02 0.520000 0.32500 0.81600
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 0.702000 0.982 0.1590 8.52e-02 0.130000 -3.08e-02 0.520000 0.32500 0.81600
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 42 0.703000 0.982 0.1060 7.74e-02 -0.068500 -2.26e-02 0.386000 0.44300 0.80000
EPH-Ephrin signaling 68 0.703000 0.982 0.0827 3.14e-02 -0.003880 7.64e-02 0.654000 0.95600 0.27600
Transcriptional activation of mitochondrial biogenesis 49 0.704000 0.982 0.0976 -7.46e-02 0.062400 7.66e-03 0.367000 0.45000 0.92600
Generic Transcription Pathway 895 0.705000 0.982 0.0237 1.05e-03 -0.017200 1.63e-02 0.958000 0.38900 0.41600
Translesion synthesis by POLI 17 0.709000 0.982 0.1660 -1.61e-01 -0.013100 3.62e-02 0.250000 0.92500 0.79600
GRB2 events in ERBB2 signaling 12 0.710000 0.982 0.1960 -2.55e-02 0.081700 1.76e-01 0.879000 0.62400 0.29000
RHO GTPase Effectors 178 0.710000 0.982 0.0511 2.68e-03 0.008360 5.04e-02 0.951000 0.84800 0.24800
Transcriptional Regulation by E2F6 31 0.710000 0.982 0.1230 -7.03e-02 -0.093400 3.87e-02 0.498000 0.36900 0.71000
SIRT1 negatively regulates rRNA expression 10 0.711000 0.982 0.2170 1.65e-01 0.040400 -1.35e-01 0.366000 0.82500 0.45900
Activation of NMDA receptors and postsynaptic events 52 0.711000 0.982 0.0939 2.25e-02 -0.086400 2.92e-02 0.779000 0.28200 0.71600
Extension of Telomeres 27 0.711000 0.982 0.1300 -6.57e-02 -0.054800 -9.73e-02 0.555000 0.62200 0.38200
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 0.712000 0.982 0.1940 -8.73e-02 0.082600 -1.52e-01 0.601000 0.62100 0.36200
FLT3 Signaling 187 0.712000 0.982 0.0503 -4.09e-02 -0.024800 1.56e-02 0.336000 0.55900 0.71400
GLI3 is processed to GLI3R by the proteasome 51 0.713000 0.982 0.0939 5.40e-02 -0.055500 5.31e-02 0.505000 0.49300 0.51200
Formation of the ternary complex, and subsequently, the 43S complex 37 0.714000 0.982 0.1110 -4.28e-03 -0.037800 1.05e-01 0.964000 0.69100 0.27100
Metabolism of polyamines 47 0.714000 0.982 0.0978 7.44e-02 -0.061100 1.69e-02 0.378000 0.46900 0.84100
Adaptive Immune System 507 0.715000 0.982 0.0303 1.45e-02 -0.026500 2.99e-03 0.579000 0.31200 0.90900
Laminin interactions 20 0.715000 0.982 0.1520 -3.99e-02 -0.036900 1.42e-01 0.758000 0.77500 0.27300
Mitotic Prophase 76 0.715000 0.982 0.0784 5.87e-02 0.021900 -4.71e-02 0.377000 0.74100 0.47800
Cell-extracellular matrix interactions 15 0.716000 0.982 0.1760 -1.33e-01 -0.048600 1.04e-01 0.373000 0.74500 0.48500
tRNA processing 85 0.717000 0.982 0.0729 9.48e-03 -0.063600 -3.44e-02 0.880000 0.31200 0.58400
Signaling by FGFR in disease 45 0.718000 0.982 0.1010 -5.62e-02 0.030600 7.76e-02 0.514000 0.72300 0.36800
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 12 0.721000 0.982 0.1910 -1.66e-01 0.047900 -8.13e-02 0.320000 0.77400 0.62600
Metalloprotease DUBs 16 0.721000 0.982 0.1680 -1.57e-01 0.022700 5.48e-02 0.278000 0.87500 0.70400
Cyclin A:Cdk2-associated events at S phase entry 70 0.722000 0.982 0.0799 -6.40e-02 -0.044700 -1.72e-02 0.355000 0.51900 0.80400
Sema4D induced cell migration and growth-cone collapse 19 0.722000 0.982 0.1520 1.19e-01 0.058400 7.46e-02 0.370000 0.65900 0.57400
Immune System 1295 0.723000 0.982 0.0194 1.92e-02 -0.001040 2.80e-03 0.257000 0.95100 0.86800
rRNA processing in the nucleus and cytosol 135 0.725000 0.982 0.0569 -4.88e-02 0.028800 -5.66e-03 0.329000 0.56400 0.91000
Binding and Uptake of Ligands by Scavenger Receptors 24 0.728000 0.982 0.1340 -6.00e-02 -0.045900 -1.10e-01 0.611000 0.69700 0.34900
Downstream signal transduction 27 0.728000 0.982 0.1280 8.59e-02 -0.006890 -9.51e-02 0.440000 0.95100 0.39300
Assembly of collagen fibrils and other multimeric structures 41 0.729000 0.982 0.1020 5.42e-02 -0.084700 1.88e-02 0.549000 0.34800 0.83500
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 16 0.730000 0.982 0.1640 -1.62e-01 0.027700 1.01e-02 0.263000 0.84800 0.94400
APC-Cdc20 mediated degradation of Nek2A 20 0.731000 0.982 0.1480 -1.14e-01 0.050000 8.00e-02 0.380000 0.69900 0.53600
SUMOylation of ubiquitinylation proteins 37 0.734000 0.982 0.1070 -2.04e-02 0.013800 -1.04e-01 0.830000 0.88400 0.27300
Activation of BAD and translocation to mitochondria 13 0.736000 0.982 0.1800 5.63e-02 0.055200 1.61e-01 0.725000 0.73100 0.31400
InlB-mediated entry of Listeria monocytogenes into host cell 13 0.736000 0.982 0.1820 -5.26e-02 -0.033100 1.71e-01 0.743000 0.83600 0.28600
Cellular Senescence 113 0.738000 0.982 0.0621 -4.50e-02 -0.030300 3.03e-02 0.410000 0.57900 0.57900
Signal regulatory protein family interactions 11 0.738000 0.982 0.1980 1.40e-01 -0.014300 -1.38e-01 0.420000 0.93400 0.42700
Activation of gene expression by SREBF (SREBP) 37 0.738000 0.982 0.1070 -1.48e-02 -0.101000 -3.17e-02 0.876000 0.28900 0.73900
CDT1 association with the CDC6:ORC:origin complex 46 0.739000 0.982 0.0957 8.87e-03 -0.089300 3.32e-02 0.917000 0.29500 0.69700
Cargo recognition for clathrin-mediated endocytosis 76 0.739000 0.982 0.0742 1.93e-02 0.046300 5.46e-02 0.771000 0.48600 0.41100
EPHB-mediated forward signaling 29 0.740000 0.982 0.1200 9.78e-02 0.068400 1.65e-02 0.362000 0.52400 0.87800
ABC transporters in lipid homeostasis 11 0.741000 0.982 0.1950 -1.03e-01 0.126000 1.07e-01 0.553000 0.47000 0.53800
Gap-filling DNA repair synthesis and ligation in GG-NER 23 0.741000 0.982 0.1360 6.99e-02 -0.024500 -1.14e-01 0.562000 0.83900 0.34600
PI3K Cascade 22 0.743000 0.982 0.1380 1.25e-01 0.008360 -5.88e-02 0.310000 0.94600 0.63300
Chaperonin-mediated protein folding 65 0.745000 0.982 0.0793 3.96e-02 -0.068700 9.68e-05 0.581000 0.33800 0.99900
Ubiquitin-dependent degradation of Cyclin D 44 0.745000 0.982 0.0972 -2.77e-02 -0.092000 1.49e-02 0.751000 0.29100 0.86500
Acyl chain remodelling of PE 11 0.746000 0.982 0.1950 9.18e-02 0.159000 -6.44e-02 0.598000 0.36100 0.71200
Prefoldin mediated transfer of substrate to CCT/TriC 20 0.747000 0.982 0.1420 7.05e-02 -0.109000 5.77e-02 0.585000 0.40000 0.65500
Antigen processing-Cross presentation 74 0.748000 0.982 0.0749 -2.41e-02 -0.006540 7.06e-02 0.720000 0.92300 0.29400
Interleukin-10 signaling 15 0.749000 0.982 0.1640 -1.16e-01 -0.075600 -8.68e-02 0.435000 0.61200 0.56100
Gene Silencing by RNA 64 0.750000 0.982 0.0795 6.32e-02 0.040700 2.60e-02 0.383000 0.57400 0.72000
IL-6-type cytokine receptor ligand interactions 12 0.751000 0.982 0.1830 2.12e-02 -0.129000 1.29e-01 0.899000 0.43900 0.44000
CD28 co-stimulation 22 0.752000 0.982 0.1350 7.02e-02 -0.099200 -5.89e-02 0.569000 0.42100 0.63200
HATs acetylate histones 73 0.754000 0.982 0.0740 -1.27e-02 0.072800 -2.25e-03 0.851000 0.28300 0.97400
CTLA4 inhibitory signaling 17 0.757000 0.982 0.1540 -6.65e-02 -0.099500 9.71e-02 0.635000 0.47800 0.48800
Opioid Signalling 68 0.757000 0.982 0.0756 6.17e-02 -0.014000 4.13e-02 0.379000 0.84200 0.55600
Cyclin E associated events during G1/S transition 68 0.758000 0.982 0.0764 -6.20e-02 -0.042100 -1.47e-02 0.377000 0.54800 0.83400
Regulation of Apoptosis 45 0.758000 0.982 0.0943 -3.00e-02 -0.079300 4.14e-02 0.728000 0.35800 0.63100
DNA strand elongation 28 0.758000 0.982 0.1170 -9.35e-02 0.008890 -7.03e-02 0.392000 0.93500 0.52000
Hedgehog ligand biogenesis 49 0.758000 0.982 0.0902 -6.52e-02 -0.062200 3.67e-03 0.430000 0.45200 0.96500
Fatty acyl-CoA biosynthesis 19 0.760000 0.982 0.1430 1.22e-01 -0.074700 -4.70e-03 0.359000 0.57300 0.97200
Gap junction trafficking and regulation 15 0.761000 0.982 0.1600 -1.47e-01 0.008090 -6.19e-02 0.324000 0.95700 0.67800
Cell-Cell communication 74 0.762000 0.982 0.0724 1.04e-02 -0.060000 -3.93e-02 0.878000 0.37300 0.56000
ERBB2 Regulates Cell Motility 11 0.763000 0.982 0.1890 -1.54e-01 0.042400 1.01e-01 0.377000 0.80800 0.56200
Golgi Cisternae Pericentriolar Stack Reorganization 10 0.763000 0.982 0.1960 7.88e-02 0.147000 1.02e-01 0.666000 0.41900 0.57500
PECAM1 interactions 10 0.763000 0.982 0.1970 3.00e-02 -0.010700 -1.95e-01 0.869000 0.95300 0.28700
Transcriptional regulation by small RNAs 44 0.763000 0.982 0.0941 9.30e-02 -0.003290 -1.40e-02 0.286000 0.97000 0.87300
Sema4D in semaphorin signaling 23 0.765000 0.982 0.1290 6.21e-02 0.109000 3.14e-02 0.607000 0.36500 0.79500
Cytosolic sulfonation of small molecules 11 0.765000 0.982 0.1880 -4.87e-02 -0.088700 1.59e-01 0.780000 0.61100 0.36200
Synthesis of IP2, IP, and Ins in the cytosol 13 0.767000 0.982 0.1720 -1.06e-01 -0.135000 1.78e-03 0.507000 0.39800 0.99100
ER Quality Control Compartment (ERQC) 19 0.773000 0.982 0.1390 3.34e-02 0.081600 1.08e-01 0.801000 0.53800 0.41600
Collagen formation 61 0.776000 0.982 0.0787 5.58e-02 0.050200 -2.36e-02 0.451000 0.49800 0.75000
SUMOylation of DNA damage response and repair proteins 70 0.779000 0.982 0.0726 -5.17e-02 -0.050800 -4.96e-03 0.455000 0.46300 0.94300
rRNA processing 141 0.779000 0.982 0.0507 -4.22e-02 0.026700 -8.72e-03 0.388000 0.58500 0.85800
CDK-mediated phosphorylation and removal of Cdc6 57 0.779000 0.982 0.0806 -6.46e-02 -0.047700 6.06e-03 0.399000 0.53300 0.93700
Vif-mediated degradation of APOBEC3G 43 0.780000 0.982 0.0922 7.39e-05 -0.076000 5.22e-02 0.999000 0.38900 0.55400
Oncogene Induced Senescence 30 0.780000 0.982 0.1100 1.53e-03 -0.025800 1.07e-01 0.988000 0.80700 0.31100
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 0.781000 0.982 0.0927 -3.80e-02 -0.071600 4.50e-02 0.666000 0.41700 0.61000
p53-Independent DNA Damage Response 43 0.781000 0.982 0.0927 -3.80e-02 -0.071600 4.50e-02 0.666000 0.41700 0.61000
p53-Independent G1/S DNA damage checkpoint 43 0.781000 0.982 0.0927 -3.80e-02 -0.071600 4.50e-02 0.666000 0.41700 0.61000
Signaling by EGFR in Cancer 21 0.781000 0.982 0.1320 4.18e-02 0.125000 2.07e-03 0.740000 0.32300 0.98700
Hemostasis 367 0.782000 0.982 0.0318 -1.11e-02 0.023200 1.86e-02 0.717000 0.44700 0.54300
Signaling by the B Cell Receptor (BCR) 88 0.782000 0.982 0.0647 -4.53e-02 -0.043300 1.62e-02 0.463000 0.48400 0.79200
Dual incision in TC-NER 55 0.785000 0.982 0.0813 -2.12e-02 -0.044200 6.48e-02 0.786000 0.57100 0.40600
FOXO-mediated transcription of cell cycle genes 15 0.785000 0.982 0.1540 8.90e-02 -0.111000 -5.95e-02 0.551000 0.45800 0.69000
RHO GTPases activate PAKs 20 0.787000 0.982 0.1320 3.52e-02 -0.034200 1.23e-01 0.785000 0.79100 0.34100
Signaling by FGFR1 in disease 31 0.787000 0.982 0.1070 -9.23e-02 0.045700 2.89e-02 0.374000 0.66000 0.78100
Processing of Capped Intronless Pre-mRNA 24 0.787000 0.982 0.1220 -4.83e-02 0.002680 1.12e-01 0.682000 0.98200 0.34100
Transcriptional Regulation by TP53 291 0.791000 0.982 0.0348 7.99e-03 -0.003290 3.37e-02 0.815000 0.92300 0.32500
PI-3K cascade:FGFR2 10 0.792000 0.982 0.1870 1.76e-01 -0.019100 -5.97e-02 0.335000 0.91700 0.74400
Metabolism of cofactors 16 0.793000 0.982 0.1470 -1.28e-01 -0.068900 -2.33e-02 0.376000 0.63300 0.87200
Regulation of TP53 Activity through Acetylation 29 0.794000 0.982 0.1100 -5.96e-02 -0.058300 7.22e-02 0.578000 0.58700 0.50100
Downstream signaling of activated FGFR1 21 0.794000 0.982 0.1270 1.12e-01 -0.059300 1.05e-02 0.374000 0.63800 0.93400
Nucleotide Excision Repair 96 0.794000 0.982 0.0606 -2.30e-02 -0.045800 3.23e-02 0.697000 0.43900 0.58500
Hh mutants abrogate ligand secretion 46 0.798000 0.982 0.0867 -5.62e-02 -0.060200 2.69e-02 0.510000 0.48000 0.75200
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 46 0.798000 0.982 0.0867 -5.62e-02 -0.060200 2.69e-02 0.510000 0.48000 0.75200
Meiosis 40 0.801000 0.982 0.0920 -7.59e-02 0.027300 4.42e-02 0.406000 0.76600 0.62900
Platelet activation, signaling and aggregation 168 0.802000 0.982 0.0452 -2.41e-02 -0.004790 3.80e-02 0.592000 0.91500 0.39700
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 0.802000 0.982 0.0896 -2.66e-02 -0.079400 3.19e-02 0.765000 0.37400 0.72100
PRC2 methylates histones and DNA 15 0.805000 0.982 0.1480 -2.20e-02 0.121000 -8.20e-02 0.883000 0.41700 0.58300
ER-Phagosome pathway 65 0.806000 0.982 0.0718 -2.85e-02 -0.052300 4.02e-02 0.691000 0.46700 0.57600
RAF activation 30 0.806000 0.982 0.1040 4.64e-02 -0.090500 -2.29e-02 0.660000 0.39100 0.82800
Constitutive Signaling by AKT1 E17K in Cancer 23 0.808000 0.982 0.1190 1.91e-03 -0.115000 -2.94e-02 0.987000 0.34000 0.80700
The role of GTSE1 in G2/M progression after G2 checkpoint 49 0.809000 0.982 0.0813 1.00e-02 -0.070800 3.87e-02 0.903000 0.39200 0.63900
Translesion synthesis by REV1 16 0.809000 0.982 0.1420 -1.28e-01 0.046000 4.19e-02 0.375000 0.75000 0.77200
DNA Damage Bypass 42 0.811000 0.982 0.0880 -8.01e-02 0.008060 3.54e-02 0.369000 0.92800 0.69100
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 44 0.812000 0.982 0.0848 1.91e-02 0.004590 8.25e-02 0.827000 0.95800 0.34400
Signaling by TGF-beta Receptor Complex 66 0.812000 0.982 0.0701 -1.59e-02 -0.054700 4.08e-02 0.824000 0.44300 0.56700
Influenza Infection 115 0.812000 0.982 0.0526 1.06e-02 -0.011400 5.02e-02 0.844000 0.83200 0.35300
Notch-HLH transcription pathway 28 0.813000 0.982 0.1070 -9.95e-02 -0.037000 1.54e-02 0.363000 0.73500 0.88800
TRAF6 mediated IRF7 activation 13 0.814000 0.982 0.1560 -2.28e-02 0.148000 4.27e-02 0.887000 0.35600 0.79000
Defects in cobalamin (B12) metabolism 10 0.814000 0.982 0.1790 1.59e-01 -0.015000 -8.05e-02 0.383000 0.93500 0.65900
LDL clearance 16 0.814000 0.982 0.1410 -2.76e-03 0.103000 -9.61e-02 0.985000 0.47600 0.50600
Epigenetic regulation of gene expression 78 0.818000 0.982 0.0641 3.49e-02 0.021300 -4.93e-02 0.594000 0.74600 0.45200
Signaling by TGF-beta family members 90 0.818000 0.982 0.0593 -2.00e-02 -0.047700 2.91e-02 0.744000 0.43400 0.63400
Phospholipid metabolism 153 0.819000 0.982 0.0449 1.46e-02 0.020200 3.74e-02 0.756000 0.66600 0.42600
MET promotes cell motility 24 0.820000 0.982 0.1130 -3.66e-02 0.092500 5.40e-02 0.756000 0.43300 0.64700
Synthesis of DNA 94 0.822000 0.982 0.0571 -3.37e-02 -0.042400 -1.82e-02 0.573000 0.47800 0.76100
Energy dependent regulation of mTOR by LKB1-AMPK 26 0.822000 0.982 0.1080 -1.46e-02 0.107000 -6.79e-03 0.898000 0.34500 0.95200
Integrin cell surface interactions 43 0.822000 0.982 0.0841 1.23e-02 -0.083200 7.30e-04 0.889000 0.34600 0.99300
Regulation of KIT signaling 14 0.823000 0.982 0.1480 4.34e-02 0.004850 -1.41e-01 0.778000 0.97500 0.36000
Synthesis of PC 21 0.824000 0.982 0.1210 -6.46e-02 0.027000 9.86e-02 0.609000 0.83100 0.43400
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 19 0.824000 0.982 0.1270 2.88e-02 0.122000 -1.56e-02 0.828000 0.35600 0.90600
Post NMDA receptor activation events 45 0.824000 0.982 0.0815 6.15e-02 -0.053000 6.63e-03 0.475000 0.53800 0.93900
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 65 0.825000 0.982 0.0683 -3.56e-02 0.037000 4.51e-02 0.620000 0.60700 0.53000
NIK–>noncanonical NF-kB signaling 50 0.826000 0.982 0.0770 4.99e-02 -0.056800 1.45e-02 0.542000 0.48800 0.85900
Golgi-to-ER retrograde transport 86 0.826000 0.982 0.0590 9.77e-03 0.037300 4.46e-02 0.876000 0.55000 0.47500
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 22 0.827000 0.982 0.1160 7.83e-02 -0.070900 -4.90e-02 0.525000 0.56500 0.69100
Signaling by Retinoic Acid 32 0.828000 0.982 0.0953 7.46e-02 -0.017600 5.66e-02 0.466000 0.86400 0.58000
Budding and maturation of HIV virion 23 0.829000 0.982 0.1130 3.73e-02 -0.038800 9.90e-02 0.757000 0.74800 0.41100
Loss of function of MECP2 in Rett syndrome 11 0.830000 0.982 0.1630 -1.48e-01 0.065500 2.21e-02 0.396000 0.70700 0.89900
Pervasive developmental disorders 11 0.830000 0.982 0.1630 -1.48e-01 0.065500 2.21e-02 0.396000 0.70700 0.89900
Metabolism of lipids 500 0.831000 0.982 0.0246 4.18e-03 0.017200 1.71e-02 0.874000 0.51500 0.51600
Viral Messenger RNA Synthesis 38 0.831000 0.982 0.0885 7.64e-02 -0.009280 -4.37e-02 0.415000 0.92100 0.64100
RNA Polymerase II Transcription 995 0.832000 0.982 0.0178 1.85e-03 -0.012700 1.23e-02 0.923000 0.50400 0.51900
Phase 0 - rapid depolarisation 25 0.833000 0.982 0.1070 5.62e-02 -0.055700 7.17e-02 0.627000 0.63000 0.53500
ABC transporter disorders 60 0.834000 0.982 0.0697 -3.77e-02 0.039500 4.33e-02 0.614000 0.59700 0.56200
Disorders of transmembrane transporters 118 0.834000 0.982 0.0495 -8.08e-03 -0.012100 -4.73e-02 0.880000 0.82100 0.37600
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 70 0.837000 0.982 0.0643 5.98e-02 0.022900 -5.39e-03 0.388000 0.74100 0.93800
Orc1 removal from chromatin 54 0.838000 0.982 0.0719 4.53e-02 -0.038200 4.07e-02 0.565000 0.62700 0.60600
Peptide ligand-binding receptors 38 0.838000 0.982 0.0862 -1.53e-02 -0.070700 -4.69e-02 0.871000 0.45100 0.61700
Meiotic synapsis 24 0.838000 0.982 0.1090 -1.33e-02 -0.011900 1.07e-01 0.910000 0.92000 0.36300
Downstream signaling events of B Cell Receptor (BCR) 67 0.838000 0.982 0.0646 2.65e-02 -0.036600 4.62e-02 0.708000 0.60500 0.51400
Import of palmitoyl-CoA into the mitochondrial matrix 11 0.839000 0.982 0.1590 -6.82e-02 0.140000 -3.49e-02 0.696000 0.42300 0.84100
Signaling by ERBB4 40 0.841000 0.982 0.0834 -5.19e-02 0.059000 2.81e-02 0.570000 0.51900 0.75900
Ub-specific processing proteases 144 0.841000 0.982 0.0444 -2.91e-02 0.018100 2.82e-02 0.547000 0.70800 0.56000
RNA Polymerase I Transcription Initiation 39 0.842000 0.982 0.0842 2.22e-02 0.063500 5.05e-02 0.810000 0.49300 0.58500
Synthesis of PIPs at the plasma membrane 46 0.842000 0.982 0.0774 -6.64e-02 -0.028700 -2.77e-02 0.436000 0.73600 0.74600
Amyloid fiber formation 33 0.842000 0.982 0.0912 -6.98e-02 0.058700 3.36e-03 0.488000 0.56000 0.97300
p75NTR signals via NF-kB 14 0.843000 0.982 0.1410 -5.37e-02 0.021600 1.29e-01 0.728000 0.88900 0.40400
Attenuation phase 17 0.844000 0.982 0.1290 1.04e-01 0.031500 -6.93e-02 0.459000 0.82200 0.62100
Cytokine Signaling in Immune system 548 0.846000 0.982 0.0228 2.25e-02 -0.003070 -2.03e-03 0.373000 0.90300 0.93600
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 19 0.846000 0.982 0.1190 -3.11e-02 0.088900 -7.31e-02 0.814000 0.50200 0.58100
MET activates PTK2 signaling 14 0.847000 0.982 0.1390 6.95e-02 0.104000 6.02e-02 0.653000 0.50100 0.69700
PCP/CE pathway 74 0.847000 0.982 0.0608 -6.34e-03 -0.056600 2.11e-02 0.925000 0.40000 0.75400
MAPK6/MAPK4 signaling 73 0.847000 0.982 0.0612 -7.31e-03 -0.013700 5.91e-02 0.914000 0.83900 0.38300
Inwardly rectifying K+ channels 15 0.850000 0.982 0.1330 3.12e-02 -0.107000 7.29e-02 0.834000 0.47500 0.62500
B-WICH complex positively regulates rRNA expression 28 0.850000 0.982 0.0973 6.49e-03 -0.092500 -2.96e-02 0.953000 0.39700 0.78700
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 0.851000 0.982 0.0922 1.80e-02 0.017600 8.87e-02 0.862000 0.86500 0.39300
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 0.852000 0.982 0.1610 1.10e-01 -0.100000 6.27e-02 0.549000 0.58400 0.73200
Signaling by high-kinase activity BRAF mutants 27 0.853000 0.982 0.0983 7.60e-02 0.049000 3.86e-02 0.495000 0.65900 0.72900
Base-Excision Repair, AP Site Formation 17 0.853000 0.982 0.1240 -1.22e-01 -0.014000 -1.90e-02 0.386000 0.92000 0.89200
Nonhomologous End-Joining (NHEJ) 32 0.854000 0.982 0.0910 -4.72e-02 0.010200 7.71e-02 0.644000 0.92100 0.45100
Non-integrin membrane-ECM interactions 33 0.854000 0.982 0.0879 6.20e-02 -0.025900 5.66e-02 0.538000 0.79700 0.57400
TRAF3-dependent IRF activation pathway 11 0.856000 0.982 0.1540 6.83e-02 0.136000 -2.09e-02 0.695000 0.43400 0.90500
Ion transport by P-type ATPases 36 0.857000 0.982 0.0839 3.40e-02 0.022400 7.33e-02 0.724000 0.81700 0.44700
RIPK1-mediated regulated necrosis 14 0.857000 0.982 0.1360 2.76e-02 0.059300 -1.19e-01 0.858000 0.70100 0.43900
Regulated Necrosis 14 0.857000 0.982 0.1360 2.76e-02 0.059300 -1.19e-01 0.858000 0.70100 0.43900
mRNA Splicing - Minor Pathway 39 0.858000 0.982 0.0802 6.66e-02 -0.028300 3.46e-02 0.472000 0.76000 0.70900
Collagen degradation 18 0.858000 0.982 0.1190 -2.10e-02 -0.117000 -1.27e-02 0.877000 0.39200 0.92500
FGFR2 alternative splicing 20 0.858000 0.982 0.1130 -2.12e-03 -0.090200 6.84e-02 0.987000 0.48500 0.59700
NoRC negatively regulates rRNA expression 39 0.859000 0.982 0.0814 5.58e-02 -0.013100 -5.78e-02 0.547000 0.88700 0.53200
EPH-ephrin mediated repulsion of cells 31 0.859000 0.982 0.0913 -3.57e-02 -0.009480 8.35e-02 0.731000 0.92700 0.42200
Formation of tubulin folding intermediates by CCT/TriC 16 0.860000 0.982 0.1250 2.43e-02 -0.093800 7.94e-02 0.866000 0.51600 0.58200
Condensation of Prophase Chromosomes 14 0.861000 0.982 0.1340 5.75e-02 0.093000 7.67e-02 0.710000 0.54700 0.62000
Fatty acid metabolism 102 0.861000 0.982 0.0501 -4.76e-02 -0.006620 1.41e-02 0.407000 0.90800 0.80600
PI3K/AKT Signaling in Cancer 65 0.863000 0.982 0.0619 2.83e-02 -0.045100 -3.17e-02 0.693000 0.53000 0.65900
Degradation of GLI1 by the proteasome 50 0.864000 0.982 0.0698 3.20e-02 -0.016000 6.00e-02 0.696000 0.84500 0.46400
DNA Replication 97 0.864000 0.982 0.0507 -2.92e-02 -0.040900 -6.75e-03 0.620000 0.48700 0.90900
IRAK2 mediated activation of TAK1 complex 10 0.865000 0.982 0.1550 9.04e-02 -0.031100 1.22e-01 0.621000 0.86500 0.50500
Selenocysteine synthesis 63 0.870000 0.982 0.0622 -4.52e-02 0.008510 4.19e-02 0.536000 0.90700 0.56500
Assembly of the pre-replicative complex 53 0.870000 0.982 0.0667 2.45e-02 -0.048500 3.86e-02 0.757000 0.54200 0.62700
Post-translational modification: synthesis of GPI-anchored proteins 41 0.873000 0.982 0.0752 2.34e-02 -0.053900 4.69e-02 0.796000 0.55100 0.60300
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 26 0.875000 0.982 0.0953 6.68e-02 0.064000 -2.30e-02 0.556000 0.57300 0.83900
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 57 0.875000 0.982 0.0641 -5.07e-02 -0.039200 1.40e-03 0.509000 0.60900 0.98500
Scavenging by Class A Receptors 11 0.875000 0.982 0.1450 -1.41e-01 0.030100 1.53e-02 0.419000 0.86300 0.93000
Influenza Life Cycle 105 0.876000 0.982 0.0466 1.36e-02 -0.004820 4.43e-02 0.810000 0.93200 0.43400
Downregulation of TGF-beta receptor signaling 25 0.876000 0.982 0.0960 -2.45e-02 -0.092800 2.78e-03 0.832000 0.42200 0.98100
Gene expression (Transcription) 1109 0.877000 0.982 0.0149 1.26e-02 -0.006830 3.78e-03 0.486000 0.70600 0.83500
G1/S Transition 100 0.878000 0.982 0.0478 -8.91e-03 -0.046700 -4.62e-03 0.878000 0.42000 0.93600
Rab regulation of trafficking 102 0.879000 0.982 0.0470 1.68e-02 -0.038800 2.03e-02 0.769000 0.49900 0.72300
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 0.880000 0.982 0.1490 2.18e-02 -0.103000 -1.06e-01 0.905000 0.57400 0.56100
alpha-linolenic acid (ALA) metabolism 10 0.880000 0.982 0.1490 2.18e-02 -0.103000 -1.06e-01 0.905000 0.57400 0.56100
Apoptotic factor-mediated response 16 0.881000 0.982 0.1170 8.59e-02 -0.079100 1.06e-02 0.552000 0.58400 0.94200
TRAF6 mediated NF-kB activation 18 0.881000 0.982 0.1120 1.06e-01 -0.008810 -3.57e-02 0.438000 0.94800 0.79300
Alpha-protein kinase 1 signaling pathway 11 0.882000 0.982 0.1410 -1.20e-01 -0.056100 -4.79e-02 0.490000 0.74700 0.78300
Translesion synthesis by POLK 17 0.883000 0.982 0.1130 -8.18e-02 0.077500 8.38e-03 0.559000 0.58000 0.95200
TICAM1, RIP1-mediated IKK complex recruitment 18 0.884000 0.982 0.1110 6.56e-02 0.006230 -8.96e-02 0.630000 0.96400 0.51100
RHO GTPases Activate Formins 83 0.884000 0.982 0.0519 -3.46e-02 -0.034400 1.78e-02 0.587000 0.58800 0.78000
E2F mediated regulation of DNA replication 17 0.884000 0.982 0.1140 2.73e-02 -0.018000 -1.09e-01 0.845000 0.89800 0.43700
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 17 0.885000 0.982 0.1120 6.10e-02 -0.057500 7.43e-02 0.663000 0.68100 0.59600
Neurodegenerative Diseases 17 0.885000 0.982 0.1120 6.10e-02 -0.057500 7.43e-02 0.663000 0.68100 0.59600
SCF-beta-TrCP mediated degradation of Emi1 46 0.885000 0.982 0.0684 2.95e-02 -0.057800 2.17e-02 0.729000 0.49800 0.79900
Regulation of RAS by GAPs 58 0.886000 0.982 0.0607 2.42e-02 -0.047800 2.86e-02 0.750000 0.53000 0.70700
Signaling by SCF-KIT 34 0.886000 0.982 0.0795 -2.67e-03 -0.074800 -2.68e-02 0.979000 0.45100 0.78700
Defective B4GALT7 causes EDS, progeroid type 12 0.888000 0.982 0.1330 1.02e-01 -0.084600 -6.10e-03 0.541000 0.61200 0.97100
Keratan sulfate biosynthesis 18 0.889000 0.982 0.1090 -6.86e-02 0.005720 8.47e-02 0.614000 0.96700 0.53400
Deposition of new CENPA-containing nucleosomes at the centromere 18 0.890000 0.982 0.1080 3.46e-02 -0.092400 -4.30e-02 0.799000 0.49700 0.75200
Nucleosome assembly 18 0.890000 0.982 0.1080 3.46e-02 -0.092400 -4.30e-02 0.799000 0.49700 0.75200
Ovarian tumor domain proteases 33 0.890000 0.982 0.0802 -6.89e-02 0.011600 3.94e-02 0.494000 0.90800 0.69500
EGFR downregulation 25 0.893000 0.982 0.0896 6.74e-02 -0.040600 4.29e-02 0.560000 0.72600 0.71100
HSF1-dependent transactivation 26 0.893000 0.982 0.0899 6.28e-02 0.041600 -4.90e-02 0.579000 0.71400 0.66600
RHO GTPases Activate ROCKs 19 0.893000 0.982 0.1040 9.17e-03 -0.013200 1.02e-01 0.945000 0.92100 0.44000
Cleavage of the damaged pyrimidine 15 0.896000 0.982 0.1150 -1.10e-01 -0.029200 -2.00e-02 0.461000 0.84500 0.89300
Depyrimidination 15 0.896000 0.982 0.1150 -1.10e-01 -0.029200 -2.00e-02 0.461000 0.84500 0.89300
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 15 0.896000 0.982 0.1150 -1.10e-01 -0.029200 -2.00e-02 0.461000 0.84500 0.89300
Regulation of RUNX3 expression and activity 46 0.898000 0.982 0.0657 2.37e-02 -0.052500 -3.16e-02 0.781000 0.53800 0.71100
Autodegradation of the E3 ubiquitin ligase COP1 44 0.898000 0.982 0.0675 -1.13e-02 -0.063800 1.88e-02 0.897000 0.46400 0.82900
Integration of energy metabolism 75 0.898000 0.982 0.0511 2.33e-02 0.014900 4.30e-02 0.728000 0.82400 0.52000
DNA Replication Pre-Initiation 63 0.898000 0.982 0.0562 -1.86e-03 -0.056000 -3.21e-03 0.980000 0.44200 0.96500
Metabolic disorders of biological oxidation enzymes 17 0.898000 0.982 0.1080 1.02e-01 -0.024600 -2.33e-02 0.465000 0.86000 0.86800
Initiation of Nuclear Envelope Reformation 12 0.899000 0.982 0.1280 2.16e-02 -0.110000 6.16e-02 0.897000 0.51000 0.71200
Nuclear Envelope Reassembly 12 0.899000 0.982 0.1280 2.16e-02 -0.110000 6.16e-02 0.897000 0.51000 0.71200
Translation 219 0.903000 0.982 0.0295 2.55e-02 0.001340 1.49e-02 0.518000 0.97300 0.70500
Generation of second messenger molecules 18 0.904000 0.982 0.1020 9.78e-02 0.008420 2.73e-02 0.473000 0.95100 0.84100
G1/S DNA Damage Checkpoints 54 0.905000 0.982 0.0596 -3.66e-02 -0.044500 1.53e-02 0.642000 0.57200 0.84600
Translation initiation complex formation 43 0.905000 0.982 0.0659 5.51e-03 0.016800 6.35e-02 0.950000 0.84900 0.47100
Paradoxical activation of RAF signaling by kinase inactive BRAF 36 0.905000 0.982 0.0717 6.11e-02 0.016800 3.35e-02 0.526000 0.86100 0.72800
Signaling by RAS mutants 36 0.905000 0.982 0.0717 6.11e-02 0.016800 3.35e-02 0.526000 0.86100 0.72800
Signaling by moderate kinase activity BRAF mutants 36 0.905000 0.982 0.0717 6.11e-02 0.016800 3.35e-02 0.526000 0.86100 0.72800
Signaling downstream of RAS mutants 36 0.905000 0.982 0.0717 6.11e-02 0.016800 3.35e-02 0.526000 0.86100 0.72800
MAP2K and MAPK activation 30 0.906000 0.982 0.0791 2.88e-02 0.071900 1.57e-02 0.785000 0.49500 0.88200
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 33 0.906000 0.982 0.0746 5.11e-02 0.033600 4.28e-02 0.612000 0.73900 0.67000
Clathrin-mediated endocytosis 110 0.908000 0.982 0.0406 1.86e-02 0.007530 3.53e-02 0.736000 0.89200 0.52300
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 0.908000 0.982 0.0727 -5.67e-02 0.038600 -2.43e-02 0.568000 0.69700 0.80600
Gap-filling DNA repair synthesis and ligation in TC-NER 54 0.909000 0.982 0.0576 3.59e-02 -0.035800 2.74e-02 0.648000 0.64900 0.72800
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 0.909000 0.982 0.1220 1.16e-01 0.010700 3.63e-02 0.485000 0.94900 0.82800
Signaling by PDGF 44 0.910000 0.982 0.0639 2.32e-02 -0.059300 -5.28e-03 0.790000 0.49600 0.95200
RNA polymerase II transcribes snRNA genes 62 0.910000 0.982 0.0537 2.84e-02 -0.039200 2.32e-02 0.700000 0.59400 0.75200
Influenza Viral RNA Transcription and Replication 98 0.910000 0.982 0.0430 4.97e-03 -0.016200 3.95e-02 0.932000 0.78200 0.50000
Stimuli-sensing channels 52 0.912000 0.982 0.0586 3.22e-02 0.048700 5.00e-03 0.688000 0.54400 0.95000
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 57 0.912000 0.982 0.0562 -3.47e-02 -0.042500 1.24e-02 0.651000 0.57900 0.87200
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 57 0.912000 0.982 0.0562 -3.47e-02 -0.042500 1.24e-02 0.651000 0.57900 0.87200
UCH proteinases 75 0.913000 0.982 0.0488 -2.51e-02 0.004080 4.17e-02 0.707000 0.95100 0.53300
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 0.914000 0.982 0.1260 1.11e-01 -0.043100 -4.21e-02 0.524000 0.80500 0.80900
Transcriptional regulation by RUNX2 96 0.914000 0.982 0.0427 9.32e-04 0.003980 4.25e-02 0.987000 0.94600 0.47200
Macroautophagy 76 0.916000 0.982 0.0476 4.14e-03 -0.031300 3.57e-02 0.950000 0.63800 0.59100
Phosphorylation of the APC/C 16 0.916000 0.982 0.1030 -6.86e-02 0.076300 9.19e-03 0.635000 0.59800 0.94900
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 22 0.917000 0.982 0.0876 3.11e-02 -0.077400 2.66e-02 0.801000 0.53000 0.82900
Mitophagy 23 0.917000 0.982 0.0857 3.68e-02 -0.072600 -2.68e-02 0.760000 0.54700 0.82400
Glycolysis 58 0.917000 0.982 0.0544 4.34e-02 -0.015900 -2.87e-02 0.568000 0.83400 0.70500
Signaling by EGFR 41 0.918000 0.982 0.0641 5.55e-02 0.025700 1.92e-02 0.539000 0.77600 0.83100
Host Interactions of HIV factors 109 0.918000 0.982 0.0398 -2.14e-02 -0.031800 1.09e-02 0.700000 0.56700 0.84400
Regulation of cholesterol biosynthesis by SREBP (SREBF) 49 0.921000 0.982 0.0577 2.86e-03 -0.030700 -4.87e-02 0.972000 0.71000 0.55600
COPI-mediated anterograde transport 70 0.922000 0.982 0.0483 4.70e-02 0.011000 -1.26e-03 0.497000 0.87300 0.98500
TRAF6-mediated induction of TAK1 complex within TLR4 complex 14 0.923000 0.982 0.1060 9.10e-02 -0.047100 2.74e-02 0.555000 0.76000 0.85900
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 0.924000 0.982 0.0583 4.04e-02 -0.033300 2.59e-02 0.636000 0.69700 0.76200
SCF(Skp2)-mediated degradation of p27/p21 47 0.924000 0.982 0.0583 -4.27e-02 -0.037400 -1.31e-02 0.612000 0.65800 0.87700
APC/C:Cdc20 mediated degradation of Securin 55 0.925000 0.982 0.0543 -4.51e-02 -0.024000 1.82e-02 0.563000 0.75800 0.81500
Regulation of insulin secretion 49 0.925000 0.982 0.0563 2.63e-02 0.025900 4.25e-02 0.750000 0.75400 0.60700
APC/C-mediated degradation of cell cycle proteins 65 0.925000 0.982 0.0492 4.37e-03 -0.041300 2.64e-02 0.951000 0.56500 0.71300
Regulation of mitotic cell cycle 65 0.925000 0.982 0.0492 4.37e-03 -0.041300 2.64e-02 0.951000 0.56500 0.71300
Negative regulation of NOTCH4 signaling 48 0.926000 0.982 0.0577 -2.71e-02 -0.045400 2.30e-02 0.746000 0.58600 0.78300
Collagen chain trimerization 28 0.927000 0.982 0.0742 -2.61e-03 0.072300 1.68e-02 0.981000 0.50800 0.87800
Synthesis of PIPs at the late endosome membrane 11 0.927000 0.982 0.1180 -8.72e-03 0.082700 8.39e-02 0.960000 0.63500 0.63000
IKK complex recruitment mediated by RIP1 20 0.929000 0.982 0.0877 4.75e-02 -0.010600 -7.30e-02 0.713000 0.93400 0.57200
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 67 0.929000 0.982 0.0471 3.65e-02 -0.007240 2.88e-02 0.605000 0.91900 0.68400
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 0.930000 0.982 0.0571 2.53e-03 -0.041800 3.89e-02 0.976000 0.62400 0.64900
Activation of BH3-only proteins 24 0.930000 0.982 0.0789 -3.88e-02 -0.065400 -2.11e-02 0.742000 0.57900 0.85800
RNA Pol II CTD phosphorylation and interaction with CE 20 0.930000 0.982 0.0862 -7.65e-03 0.077100 3.77e-02 0.953000 0.55000 0.77100
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 20 0.930000 0.982 0.0862 -7.65e-03 0.077100 3.77e-02 0.953000 0.55000 0.77100
TICAM1,TRAF6-dependent induction of TAK1 complex 11 0.932000 0.982 0.1160 7.42e-02 -0.059500 -6.59e-02 0.670000 0.73300 0.70500
Regulation of mRNA stability by proteins that bind AU-rich elements 75 0.933000 0.982 0.0441 4.01e-03 -0.043500 -6.04e-03 0.952000 0.51600 0.92800
Defective CFTR causes cystic fibrosis 49 0.933000 0.982 0.0543 -5.33e-02 0.010600 1.44e-03 0.519000 0.89700 0.98600
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 55 0.933000 0.982 0.0518 -4.51e-02 -0.002480 2.53e-02 0.563000 0.97500 0.74600
eNOS activation 11 0.935000 0.982 0.1130 3.62e-02 -0.107000 7.77e-03 0.835000 0.53800 0.96400
CD28 dependent PI3K/Akt signaling 14 0.935000 0.982 0.1000 6.79e-02 -0.072900 1.09e-02 0.660000 0.63700 0.94400
Glycosphingolipid metabolism 33 0.935000 0.982 0.0654 4.20e-02 -0.045700 -2.08e-02 0.677000 0.65000 0.83700
Activation of the pre-replicative complex 21 0.935000 0.982 0.0819 2.51e-02 -0.067000 -3.98e-02 0.842000 0.59500 0.75200
Vpu mediated degradation of CD4 44 0.936000 0.982 0.0564 1.35e-02 -0.052700 1.49e-02 0.877000 0.54500 0.86500
PIWI-interacting RNA (piRNA) biogenesis 15 0.937000 0.982 0.0961 -2.67e-02 0.081200 4.40e-02 0.858000 0.58600 0.76800
Metabolism of proteins 1398 0.939000 0.982 0.0105 -9.99e-03 -0.002530 1.89e-03 0.541000 0.87700 0.90800
Cellular response to hypoxia 60 0.940000 0.982 0.0475 -4.71e-02 -0.005240 2.58e-03 0.528000 0.94400 0.97200
Intra-Golgi traffic 35 0.940000 0.982 0.0622 1.65e-02 -0.001640 -5.99e-02 0.866000 0.98700 0.54000
Dectin-1 mediated noncanonical NF-kB signaling 51 0.941000 0.982 0.0506 3.21e-02 -0.039000 4.00e-03 0.692000 0.63000 0.96100
Activation of NF-kappaB in B cells 54 0.942000 0.982 0.0495 3.53e-02 -0.024400 -2.47e-02 0.654000 0.75600 0.75400
Selenoamino acid metabolism 82 0.943000 0.982 0.0397 3.69e-02 -0.013800 -4.63e-03 0.564000 0.82900 0.94200
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 59 0.943000 0.982 0.0471 -2.01e-02 -0.040000 1.46e-02 0.790000 0.59600 0.84600
Inactivation of APC/C via direct inhibition of the APC/C complex 16 0.944000 0.982 0.0885 -8.64e-02 0.003590 -1.92e-02 0.550000 0.98000 0.89400
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 16 0.944000 0.982 0.0885 -8.64e-02 0.003590 -1.92e-02 0.550000 0.98000 0.89400
Intrinsic Pathway of Fibrin Clot Formation 11 0.945000 0.982 0.1070 4.00e-02 -0.097200 -1.88e-02 0.818000 0.57700 0.91400
Gluconeogenesis 22 0.945000 0.982 0.0754 -2.92e-02 0.069500 1.26e-03 0.813000 0.57300 0.99200
Resolution of Abasic Sites (AP sites) 35 0.945000 0.982 0.0598 3.61e-02 -0.046700 -9.40e-03 0.712000 0.63300 0.92300
Base Excision Repair 42 0.946000 0.982 0.0544 -3.36e-04 -0.044100 -3.19e-02 0.997000 0.62100 0.72100
Formation of Fibrin Clot (Clotting Cascade) 17 0.947000 0.982 0.0849 -1.48e-02 0.067400 -4.95e-02 0.916000 0.63100 0.72400
A tetrasaccharide linker sequence is required for GAG synthesis 15 0.947000 0.982 0.0909 -1.22e-02 -0.075700 4.89e-02 0.935000 0.61200 0.74300
Regulation of APC/C activators between G1/S and early anaphase 64 0.948000 0.982 0.0435 1.19e-02 -0.039700 1.33e-02 0.869000 0.58300 0.85400
Regulation of localization of FOXO transcription factors 11 0.948000 0.982 0.1060 4.98e-02 0.068300 -6.43e-02 0.775000 0.69500 0.71200
Cristae formation 10 0.949000 0.982 0.1100 -1.05e-01 0.004380 3.05e-02 0.564000 0.98100 0.86800
Synthesis of very long-chain fatty acyl-CoAs 12 0.949000 0.982 0.0998 8.69e-02 -0.032300 -3.69e-02 0.602000 0.84600 0.82500
Autodegradation of Cdh1 by Cdh1:APC/C 55 0.950000 0.982 0.0466 -3.84e-02 -0.026400 -1.00e-04 0.622000 0.73500 0.99900
Antigen processing: Ubiquitination & Proteasome degradation 258 0.950000 0.982 0.0215 1.48e-02 -0.012800 -9.05e-03 0.684000 0.72400 0.80300
Mitochondrial Fatty Acid Beta-Oxidation 27 0.951000 0.982 0.0654 -4.43e-02 0.042300 2.28e-02 0.690000 0.70400 0.83800
Intra-Golgi and retrograde Golgi-to-ER traffic 143 0.952000 0.982 0.0282 2.30e-02 -0.014900 6.37e-03 0.635000 0.75900 0.89600
Switching of origins to a post-replicative state 70 0.952000 0.982 0.0406 -9.26e-03 -0.032900 2.19e-02 0.894000 0.63400 0.75200
RUNX2 regulates bone development 26 0.952000 0.982 0.0660 -4.71e-02 0.041200 2.08e-02 0.678000 0.71600 0.85400
Cross-presentation of soluble exogenous antigens (endosomes) 39 0.953000 0.982 0.0540 -3.20e-03 -0.053800 3.31e-03 0.972000 0.56200 0.97100
Metabolism of amino acids and derivatives 249 0.953000 0.982 0.0216 1.92e-02 0.005600 -8.23e-03 0.603000 0.88000 0.82400
DARPP-32 events 21 0.953000 0.982 0.0735 -6.99e-02 0.006180 2.18e-02 0.579000 0.96100 0.86300
Glutamate Neurotransmitter Release Cycle 14 0.955000 0.982 0.0893 -6.74e-02 -0.054900 2.03e-02 0.662000 0.72200 0.89600
Oncogenic MAPK signaling 58 0.955000 0.982 0.0433 -4.43e-03 0.031000 -2.99e-02 0.953000 0.68300 0.69400
AKT phosphorylates targets in the cytosol 13 0.955000 0.982 0.0903 -5.35e-02 0.032200 -6.53e-02 0.739000 0.84100 0.68400
Signaling by Activin 12 0.956000 0.982 0.0939 -8.17e-02 0.039100 -2.48e-02 0.624000 0.81500 0.88200
RHO GTPases activate PKNs 33 0.957000 0.982 0.0569 -5.02e-03 -0.024800 5.10e-02 0.960000 0.80600 0.61200
APC/C:Cdc20 mediated degradation of mitotic proteins 58 0.957000 0.982 0.0431 -1.72e-02 -0.034700 1.88e-02 0.820000 0.64800 0.80400
Asymmetric localization of PCP proteins 53 0.957000 0.982 0.0445 1.83e-02 -0.039100 -1.09e-02 0.818000 0.62300 0.89100
Fc epsilon receptor (FCERI) signaling 109 0.958000 0.982 0.0311 -5.17e-03 -0.030700 -3.44e-04 0.926000 0.58100 0.99500
Intrinsic Pathway for Apoptosis 44 0.958000 0.982 0.0487 7.32e-03 -0.046900 1.08e-02 0.933000 0.59100 0.90200
Degradation of AXIN 46 0.958000 0.982 0.0475 -7.03e-03 -0.041400 -2.23e-02 0.934000 0.62800 0.79400
Signaling by BRAF and RAF fusions 54 0.959000 0.982 0.0433 -1.90e-02 0.016600 -3.52e-02 0.810000 0.83300 0.65400
Regulation of PTEN stability and activity 58 0.959000 0.982 0.0415 -3.72e-02 0.000859 -1.85e-02 0.625000 0.99100 0.80700
mRNA Capping 22 0.960000 0.982 0.0675 9.76e-03 0.056300 3.60e-02 0.937000 0.64800 0.77000
WNT5A-dependent internalization of FZD4 12 0.960000 0.982 0.0907 2.83e-02 0.041500 7.55e-02 0.865000 0.80400 0.65100
Acyl chain remodelling of PC 13 0.961000 0.982 0.0872 -5.95e-02 0.055500 3.14e-02 0.710000 0.72900 0.84500
Syndecan interactions 15 0.962000 0.982 0.0807 1.84e-02 0.046900 -6.30e-02 0.902000 0.75300 0.67300
PI-3K cascade:FGFR1 11 0.963000 0.982 0.0929 9.26e-02 0.005550 -3.49e-03 0.595000 0.97500 0.98400
Positive epigenetic regulation of rRNA expression 43 0.965000 0.982 0.0461 -1.44e-02 -0.036600 -2.41e-02 0.870000 0.67900 0.78500
Ras activation upon Ca2+ influx through NMDA receptor 15 0.965000 0.982 0.0769 -4.46e-02 -0.004980 -6.25e-02 0.765000 0.97300 0.67500
Miscellaneous transport and binding events 19 0.965000 0.982 0.0692 -4.77e-02 -0.049700 -6.12e-03 0.719000 0.70800 0.96300
Glucose metabolism 72 0.967000 0.982 0.0351 1.55e-02 -0.022800 -2.19e-02 0.821000 0.73900 0.74900
Stabilization of p53 47 0.967000 0.982 0.0434 -1.62e-02 -0.037300 1.53e-02 0.848000 0.65900 0.85600
Termination of translesion DNA synthesis 27 0.968000 0.982 0.0561 -2.25e-02 -0.007530 -5.09e-02 0.840000 0.94600 0.64700
Constitutive Signaling by Aberrant PI3K in Cancer 41 0.968000 0.982 0.0462 4.27e-02 0.012400 -1.24e-02 0.636000 0.89100 0.89000
Synthesis of PIPs at the Golgi membrane 15 0.968000 0.982 0.0753 1.77e-02 -0.014100 7.18e-02 0.905000 0.92500 0.63000
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 0.969000 0.982 0.0447 -2.47e-02 -0.012500 3.51e-02 0.779000 0.88800 0.69100
p53-Dependent G1 DNA Damage Response 52 0.972000 0.983 0.0391 -1.79e-02 -0.034700 -1.87e-03 0.824000 0.66600 0.98100
p53-Dependent G1/S DNA damage checkpoint 52 0.972000 0.983 0.0391 -1.79e-02 -0.034700 -1.87e-03 0.824000 0.66600 0.98100
Amino acid transport across the plasma membrane 21 0.973000 0.983 0.0609 3.37e-02 0.019500 -4.69e-02 0.790000 0.87700 0.71000
Autophagy 94 0.973000 0.983 0.0287 -8.75e-03 -0.024000 1.31e-02 0.884000 0.68800 0.82700
PI Metabolism 71 0.974000 0.983 0.0320 -2.00e-02 0.024900 -1.38e-03 0.771000 0.71700 0.98400
Class I MHC mediated antigen processing & presentation 300 0.979000 0.988 0.0146 1.45e-02 -0.001600 9.94e-04 0.667000 0.96200 0.97600
Glycogen metabolism 24 0.981000 0.989 0.0492 -4.66e-02 -0.001090 -1.57e-02 0.693000 0.99300 0.89400
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 0.983000 0.990 0.0643 3.91e-02 -0.050700 -5.65e-03 0.807000 0.75200 0.97200
FOXO-mediated transcription of cell death genes 12 0.984000 0.990 0.0666 7.80e-03 0.034400 -5.65e-02 0.963000 0.83700 0.73500
Regulation of expression of SLITs and ROBOs 121 0.985000 0.990 0.0206 4.74e-04 -0.005610 1.98e-02 0.993000 0.91500 0.70700
Metabolism of folate and pterines 13 0.986000 0.990 0.0619 4.59e-02 0.025000 -3.32e-02 0.775000 0.87600 0.83600
L1CAM interactions 69 0.989000 0.992 0.0246 -1.65e-02 0.012600 1.32e-02 0.813000 0.85600 0.85000
Global Genome Nucleotide Excision Repair (GG-NER) 75 0.990000 0.992 0.0229 -1.45e-02 0.016300 6.94e-03 0.829000 0.80700 0.91700
ABC-family proteins mediated transport 79 0.995000 0.996 0.0177 -6.29e-03 0.008380 -1.42e-02 0.923000 0.89800 0.82700
Metabolism of RNA 534 0.998000 0.998 0.0049 -2.64e-03 -0.003850 1.50e-03 0.918000 0.88000 0.95300
Pink/Parkin Mediated Mitophagy 17 0.998000 0.998 0.0264 1.74e-02 -0.016800 -1.06e-02 0.901000 0.90500 0.94000


Detailed Gene set reports


Signaling by NOTCH3 


Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).




Click HERE to show all gene set members




TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 


Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).




Click HERE to show all gene set members




Visual phototransduction 


Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).




Click HERE to show all gene set members




Protein methylation 


Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).




Click HERE to show all gene set members




GPCR ligand binding 


Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).




Click HERE to show all gene set members




Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.3 (2024-02-29)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] kableExtra_1.4.0 pkgload_1.3.4    GGally_2.2.1     ggplot2_3.5.0   
##  [5] reshape2_1.4.4   beeswarm_0.4.0   gplots_3.1.3.1   gtools_3.9.5    
##  [9] tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5  mitch_1.15.3    
## 
## loaded via a namespace (and not attached):
##  [1] gtable_0.3.4       xfun_0.43          bslib_0.7.0        htmlwidgets_1.6.4 
##  [5] caTools_1.18.2     vctrs_0.6.5        tools_4.3.3        bitops_1.0-7      
##  [9] generics_0.1.3     parallel_4.3.3     fansi_1.0.6        highr_0.10        
## [13] pkgconfig_2.0.3    KernSmooth_2.23-22 RColorBrewer_1.1-3 lifecycle_1.0.4   
## [17] compiler_4.3.3     farver_2.1.1       stringr_1.5.1      munsell_0.5.1     
## [21] httpuv_1.6.15      sass_0.4.9         htmltools_0.5.8.1  yaml_2.3.8        
## [25] later_1.3.2        pillar_1.9.0       crayon_1.5.2       jquerylib_0.1.4   
## [29] tidyr_1.3.1        MASS_7.3-60.0.1    cachem_1.0.8       mime_0.12         
## [33] ggstats_0.6.0      tidyselect_1.2.1   digest_0.6.35      stringi_1.8.3     
## [37] purrr_1.0.2        labeling_0.4.3     fastmap_1.1.1      grid_4.3.3        
## [41] colorspace_2.1-0   cli_3.6.2          magrittr_2.0.3     utf8_1.2.4        
## [45] withr_3.0.0        scales_1.3.0       promises_1.3.0     rmarkdown_2.26    
## [49] gridExtra_2.3      shiny_1.8.1.1      evaluate_0.23      knitr_1.46        
## [53] viridisLite_0.4.2  rlang_1.1.3        Rcpp_1.0.12        xtable_1.8-4      
## [57] glue_1.7.0         xml2_1.3.6         jsonlite_1.8.8     svglite_2.1.3     
## [61] rstudioapi_0.16.0  R6_2.5.1           plyr_1.8.9         systemfonts_1.0.6

END of report