Abstract

Background

   Acute myocardial infarction (AMI), characterized by an event of
   myocardial necrosis, is a common cardiac emergency worldwide. However,
   the genetic mechanisms of AMI remain largely elusive.

Methods

   A genome-wide association study dataset of AMI was obtained from the
   CARDIoGRAMplusC4D project. A transcriptome-wide association study
   (TWAS) was conducted using the FUSION tool with gene expression
   references of the left ventricle and whole blood. Significant genes