Toxotherapy and cancer risk reduction [[181]82, [146]83]. Although there are many genes that have been shown to be associated with cancer development [[182], the precise mechanism of STAT3 acetylation may result in the DNA methylation and tumor suppressor gene re-expression of these genes [[183] [[147]84, [148]85. **Questions:** 1. What tool was used for pathway enrichment analysis? - not described 2. Was a tool version number provided? - not described 3. What gene set library was queried (eg: GO, KEGG, Reactome or other)? - not described 4. Was a background gene list defined for pathway enrichment analysis? - not described 5. What statistical test was used for enrichment analysis? - not described 6. Was false discovery rate correction used to control the number of false positives in the pathway enrichment analysis? - not described