Here are the answers to the questions based on the provided scientific article: 1. **What tool was used for pathway enrichment analysis?** - The tools used for pathway enrichment analysis were Ingenuity, Webgestalt, GSEA and STRING. 2. **Was a tool version number provided?** - Not described. 3. **What gene set library was queried (e.g., GO, KEGG, Reactome or other)?** - The gene set libraries queried were KEGG, Reactome, Interpro, and MSigDB. 4. **Was a background gene list defined for pathway enrichment analysis?** - Yes. The background proteins (random entries) used were all annotated proteins presented on the 16k protein microarray. 5. **What statistical test was used for enrichment analysis?** - The statistical test used was the hypergeometric test (Webgestalt) and right-tailed Fisher’s exact test (Ingenuity). 6. **Was false discovery rate correction used to control the number of false positives in the pathway enrichment analysis?** - Not described.