Let’s start with the first question:

1. **What tool was used for pathway enrichment analysis?**
   - DAVID Bioinformatics Resource 6.9 was used for pathway enrichment analysis.

2. **Was a tool version number provided?**
   - Not described

3. **What gene set library was queried (eg: GO, KEGG, Reactome or other)?**
   - KEGG and GO were queried.

4. **Was a background gene list defined for pathway enrichment analysis?**
   - Not described

5. **What statistical test was used for enrichment analysis?**
   - Not described

6. **Was false discovery rate correction used to control the number of false positives in the pathway enrichment analysis?**
   - Not described.