Thinking... We need to answer 6 questions based on the article. We need to check the Methods section and Results for enrichment analysis details. Let's parse. From Methods 2.4: "Gene ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis The gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the Database for Annotation, Visualization, and Integration Discovery (DAVID 6.8). The P value <.05 and gene count ≥2 were set as the cutoff criteria." So tool: DAVID 6.8. Version 6.8. Gene set libraries: GO functional categories (GO: molecular function, cellular component, biological process) and KEGG. It might also include "KEGG pathway". So answer: Gene set libraries: GO and KEGG. Background gene list: Not described. The article didn't mention custom background. So "Not described". Statistical test: The article does not specify test. Usually DAVID uses modified Fisher's exact test or hypergeometric. But we need only if explicitly mentioned. It says: "The P value <.05 and gene count ≥2 were set as the cutoff criteria." It does not specify the test. So answer: Not described. Multiple testing correction: They didn't mention FDR or BH. They only mention p-value threshold. So "No" or "Not described"? They explicitly didn't mention correction. So answer: No. We need table format. Columns: What tool was used for pathway enrichment analysis? Which gene set libraries were used? Were enrichment tool version(s) described? Custom background? Statistical test(s) used? Multiple testing correction? But the prompt says: Provide output in table format. Provide 6 columns? They ask each question as separate. We'll produce a table with columns: Question, Answer. But the prompt says "Provide output in table format." So perhaps one row per question. Let's do that. Table with columns: Question, Answer. Alternatively, each question could be a separate row. Let's list questions with answer. But we might also list multiple tools if more than one. But only DAVID used. So one row per question. Thus: | Question | Answer | |----------|--------| | What tool was used for pathway enrichment analysis? | DAVID 6.8 | | Were enrichment tool version(s) described? | 6.8 | | Which gene set libraries were used? | Gene Ontology (GO: BP, MF, CC) and Kyoto Encyclopedia of Genes and Genomes (KEGG) | | Does the article describe using a custom or specific background gene list for enrichment analysis? | Not described | | What statistical test(s) were used in enrichment analysis? | Not described | | Was multiple testing correction / FDR applied to enrichment analysis? | No | But we might combine tool and version in first question. The first question asks: List all tools or software packages used. So tool: DAVID. The second question: Were enrichment tool version(s) described? yes 6.8. Ok. Thus final answer. ...done thinking. | # | Question | Answer | |---|----------|--------| | 1 | What tool was used for pathway enrichment analysis? | DAVID (Database for Annotation, Visualization, and Integration Discovery) | | 2 | Were enrichment tool version(s) described? | Yes – version 6.8 | | 3 | Which gene set libraries were used? | Gene Ontology (GO: Biological Process, Molecular Function, Cellular Component) and Kyoto Encyclopedia of Genes and Genomes (KEGG) | | 4 | Does the article describe using a custom or specific background gene list for enrichment analysis? | Not described | | 5 | What statistical test(s) were used in enrichment analysis? | Not described | | 6 | Was multiple testing correction / FDR applied to enrichment analysis? | No |