Toxic stress response proteins were also more abundant in the UC patients compared to the control group. Toxic stress abundances was 10.2 (SD = 3.4). In the group with low cluster 1 protein abundances the average Geboes score was 6.9 (SD = 4.1). This indicates that NOS2 expression is increased in abundant in patients with higher inflammation scores. The NOS2 is a key nitric oxide (NO) in response to inflammation. NO can promote molecule. The increased NOS2 expression in the inflamed tissue is consistent with previous reports of increased NOS2 expression in inflamed tissue. ### Questions and Answers: 1. **What tool was used for pathway enrichment analysis?** - **Not described** 2. **Was a tool version number provided?** - **Not described** 3. **What gene set library was queried?** - **Not described** 4. **Was a background gene list defined for pathway enrichment analysis?** - **Not described** 5. **What statistical test was used for enrichment analysis?** - **Not described** 6. **Was false discovery rate correction used to control the number of false positives in the pathway enrichment analysis?** - **Not described**