Here’s a breakdown of the pathway enrichment analysis methods described in the provided text, presented in a table format as requested: | **Question** | **Answer** | |---|---| | 1. What tool was used for pathway enrichment analysis? | R-3.4.1 with additional package piano_1.16.4 | | 2. Was a tool version number provided? | Yes, R-3.4.1 and piano_1.16.4 | | 3. What gene set library was queried (eg: GO, KEGG, Reactome or other)? | Gene Ontology (GO), KEGG (Kyoto Encyclopedia of Genes and Genomes) | | 4. Was a background gene list defined for pathway enrichment analysis? | Yes, the background was defined as "whole gene sets with corresponding Entrez-IDs of the Agilent 8 × 60K Whole Human Genome Oligo Microarray" | | 5. What statistical test was used for enrichment analysis? | Fisher’s exact test | | 6. Was false discovery rate correction used to control the number of false positives in the pathway enrichment analysis? | Yes, Benjamini-Hochberg correction was used. |