Toxic (AOS) synthase), were identified and verified. We hope our croFGD database will be a powerful tool for the functional genomics in C. roseus.

   **1. What tool was used for pathway enrichment analysis?**

The article does not describe the specific tool used for pathway enrichment analysis.

**2. Was a tool version number provided?**

Not described.

**3. What gene set library was queried (eg: GO, KEGG, Reactome or other)?**

Not described.

**4. Was a background gene list defined for pathway enrichment analysis?**

Not described.

**5. What statistical test was used for enrichment analysis?**

Not described.

**6. Was false discovery rate correction used to control the number of false positives in the pathway enrichment analysis?**

Not described.