date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -2.4785778
A1BG -1.7542512
A1BG-AS1 -1.0734376
A1CF 0.5521423
A2M 1.6603822
A2M-AS1 1.3818491

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Formation of ATP by chemiosmotic coupling 20 3.91e-11 -0.853 6.75e-10
Peptide chain elongation 88 1.15e-42 -0.843 1.31e-40
Formation of a pool of free 40S subunits 100 3.11e-48 -0.842 4.29e-46
Eukaryotic Translation Elongation 93 3.70e-44 -0.834 4.47e-42
Viral mRNA Translation 88 1.49e-41 -0.831 1.60e-39
L13a-mediated translational silencing of Ceruloplasmin expression 110 6.07e-51 -0.826 1.17e-48
Modulation by Mtb of host immune system 7 1.53e-04 -0.826 8.77e-04
GTP hydrolysis and joining of the 60S ribosomal subunit 111 7.36e-51 -0.822 1.29e-48
SARS-CoV-1 modulates host translation machinery 36 1.72e-17 -0.819 5.93e-16
Cap-dependent Translation Initiation 118 2.87e-53 -0.817 6.17e-51
Eukaryotic Translation Initiation 118 2.87e-53 -0.817 6.17e-51
Formation of the ternary complex, and subsequently, the 43S complex 51 9.14e-24 -0.813 3.92e-22
Eukaryotic Translation Termination 92 2.94e-41 -0.810 2.84e-39
Mitochondrial translation initiation 90 4.03e-40 -0.807 3.24e-38
SRP-dependent cotranslational protein targeting to membrane 111 6.91e-49 -0.805 1.03e-46
Selenocysteine synthesis 92 9.69e-41 -0.805 8.14e-39
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.37e-41 -0.802 2.41e-39
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.26e-26 -0.796 1.54e-24
Mitochondrial translation elongation 90 7.27e-39 -0.794 4.84e-37
Translation initiation complex formation 58 1.32e-25 -0.793 6.06e-24
Ribosomal scanning and start codon recognition 58 1.66e-25 -0.791 7.46e-24
Mitochondrial translation termination 90 6.58e-38 -0.783 4.24e-36
Mitochondrial translation 96 1.31e-39 -0.776 9.37e-38
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.87e-40 -0.764 4.39e-38
Complex III assembly 23 2.46e-10 -0.762 3.71e-09
Phosphate bond hydrolysis by NUDT proteins 7 5.94e-04 -0.749 2.97e-03
SUMO is conjugated to E1 (UBA2:SAE1) 5 3.99e-03 -0.743 1.57e-02
Arachidonate production from DAG 5 4.10e-03 -0.741 1.60e-02
Translation 293 0.00e+00 -0.732 1.00e-100
SARS-CoV-2 modulates host translation machinery 49 8.67e-19 -0.730 3.16e-17
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.07e-08 -0.727 4.34e-07
Selenoamino acid metabolism 115 5.91e-40 -0.713 4.39e-38
Post-transcriptional silencing by small RNAs 7 1.11e-03 0.712 5.26e-03
Cristae formation 33 2.45e-12 -0.704 5.14e-11
Mitochondrial calcium ion transport 22 1.31e-08 -0.700 1.49e-07
Packaging Of Telomere Ends 18 2.90e-07 -0.698 2.68e-06
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 1.43e-03 -0.696 6.45e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 3.99e-37 -0.689 2.41e-35
Nonsense-Mediated Decay (NMD) 114 3.99e-37 -0.689 2.41e-35
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 8.05e-03 -0.684 2.87e-02
Mitochondrial RNA degradation 25 3.17e-09 -0.684 4.06e-08
rRNA processing in the mitochondrion 24 7.81e-09 -0.680 9.38e-08
Processing of SMDT1 15 5.06e-06 -0.680 3.92e-05
RNA Polymerase I Promoter Opening 17 1.39e-06 -0.676 1.16e-05
Major pathway of rRNA processing in the nucleolus and cytosol 179 6.87e-55 -0.674 1.90e-52
rRNA processing 213 5.14e-64 -0.669 2.48e-61
Regulation of expression of SLITs and ROBOs 149 3.08e-45 -0.668 3.96e-43
Complex I biogenesis 66 5.80e-21 -0.668 2.33e-19
rRNA processing in the nucleus and cytosol 189 1.50e-56 -0.666 5.80e-54
Cleavage of the damaged purine 22 7.86e-08 -0.661 7.83e-07


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Formation of ATP by chemiosmotic coupling 20 3.91e-11 -8.53e-01 6.75e-10
Peptide chain elongation 88 1.15e-42 -8.43e-01 1.31e-40
Formation of a pool of free 40S subunits 100 3.11e-48 -8.42e-01 4.29e-46
Eukaryotic Translation Elongation 93 3.70e-44 -8.34e-01 4.47e-42
Viral mRNA Translation 88 1.49e-41 -8.31e-01 1.60e-39
L13a-mediated translational silencing of Ceruloplasmin expression 110 6.07e-51 -8.26e-01 1.17e-48
Modulation by Mtb of host immune system 7 1.53e-04 -8.26e-01 8.77e-04
GTP hydrolysis and joining of the 60S ribosomal subunit 111 7.36e-51 -8.22e-01 1.29e-48
SARS-CoV-1 modulates host translation machinery 36 1.72e-17 -8.19e-01 5.93e-16
Cap-dependent Translation Initiation 118 2.87e-53 -8.17e-01 6.17e-51
Eukaryotic Translation Initiation 118 2.87e-53 -8.17e-01 6.17e-51
Formation of the ternary complex, and subsequently, the 43S complex 51 9.14e-24 -8.13e-01 3.92e-22
Eukaryotic Translation Termination 92 2.94e-41 -8.10e-01 2.84e-39
Mitochondrial translation initiation 90 4.03e-40 -8.07e-01 3.24e-38
SRP-dependent cotranslational protein targeting to membrane 111 6.91e-49 -8.05e-01 1.03e-46
Selenocysteine synthesis 92 9.69e-41 -8.05e-01 8.14e-39
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.37e-41 -8.02e-01 2.41e-39
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.26e-26 -7.96e-01 1.54e-24
Mitochondrial translation elongation 90 7.27e-39 -7.94e-01 4.84e-37
Translation initiation complex formation 58 1.32e-25 -7.93e-01 6.06e-24
Ribosomal scanning and start codon recognition 58 1.66e-25 -7.91e-01 7.46e-24
Mitochondrial translation termination 90 6.58e-38 -7.83e-01 4.24e-36
Mitochondrial translation 96 1.31e-39 -7.76e-01 9.37e-38
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.87e-40 -7.64e-01 4.39e-38
Complex III assembly 23 2.46e-10 -7.62e-01 3.71e-09
Phosphate bond hydrolysis by NUDT proteins 7 5.94e-04 -7.49e-01 2.97e-03
SUMO is conjugated to E1 (UBA2:SAE1) 5 3.99e-03 -7.43e-01 1.57e-02
Arachidonate production from DAG 5 4.10e-03 -7.41e-01 1.60e-02
Translation 293 0.00e+00 -7.32e-01 1.00e-100
SARS-CoV-2 modulates host translation machinery 49 8.67e-19 -7.30e-01 3.16e-17
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.07e-08 -7.27e-01 4.34e-07
Selenoamino acid metabolism 115 5.91e-40 -7.13e-01 4.39e-38
Post-transcriptional silencing by small RNAs 7 1.11e-03 7.12e-01 5.26e-03
Cristae formation 33 2.45e-12 -7.04e-01 5.14e-11
Mitochondrial calcium ion transport 22 1.31e-08 -7.00e-01 1.49e-07
Packaging Of Telomere Ends 18 2.90e-07 -6.98e-01 2.68e-06
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 1.43e-03 -6.96e-01 6.45e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 3.99e-37 -6.89e-01 2.41e-35
Nonsense-Mediated Decay (NMD) 114 3.99e-37 -6.89e-01 2.41e-35
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 8.05e-03 -6.84e-01 2.87e-02
Mitochondrial RNA degradation 25 3.17e-09 -6.84e-01 4.06e-08
rRNA processing in the mitochondrion 24 7.81e-09 -6.80e-01 9.38e-08
Processing of SMDT1 15 5.06e-06 -6.80e-01 3.92e-05
RNA Polymerase I Promoter Opening 17 1.39e-06 -6.76e-01 1.16e-05
Major pathway of rRNA processing in the nucleolus and cytosol 179 6.87e-55 -6.74e-01 1.90e-52
rRNA processing 213 5.14e-64 -6.69e-01 2.48e-61
Regulation of expression of SLITs and ROBOs 149 3.08e-45 -6.68e-01 3.96e-43
Complex I biogenesis 66 5.80e-21 -6.68e-01 2.33e-19
rRNA processing in the nucleus and cytosol 189 1.50e-56 -6.66e-01 5.80e-54
Cleavage of the damaged purine 22 7.86e-08 -6.61e-01 7.83e-07
Depurination 22 7.86e-08 -6.61e-01 7.83e-07
Recognition and association of DNA glycosylase with site containing an affected purine 22 7.86e-08 -6.61e-01 7.83e-07
Recycling of eIF2:GDP 8 1.36e-03 -6.54e-01 6.20e-03
Mitochondrial protein import 63 8.36e-19 -6.45e-01 3.10e-17
Regulation of NFE2L2 gene expression 8 1.73e-03 6.40e-01 7.61e-03
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 6.73e-03 -6.39e-01 2.46e-02
Respiratory electron transport 149 4.25e-41 -6.36e-01 3.91e-39
tRNA processing in the mitochondrion 24 6.94e-08 -6.36e-01 7.14e-07
Regulation of CDH11 mRNA translation by microRNAs 8 2.03e-03 6.30e-01 8.77e-03
Regulation of NPAS4 mRNA translation 8 2.03e-03 6.30e-01 8.77e-03
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 1.47e-02 -6.30e-01 4.66e-02
Interleukin-21 signaling 9 1.11e-03 6.28e-01 5.26e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.29e-11 -6.26e-01 2.35e-10
p53-Independent DNA Damage Response 39 1.29e-11 -6.26e-01 2.35e-10
p53-Independent G1/S DNA damage checkpoint 39 1.29e-11 -6.26e-01 2.35e-10
PDH complex synthesizes acetyl-CoA from PYR 5 1.54e-02 -6.25e-01 4.86e-02
Maturation of TCA enzymes and regulation of TCA cycle 20 1.31e-06 -6.25e-01 1.10e-05
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 8.47e-03 -6.21e-01 2.97e-02
Cellular response to mitochondrial stress 9 1.27e-03 -6.20e-01 5.88e-03
Vif-mediated degradation of APOBEC3G 41 7.06e-12 -6.19e-01 1.38e-10
HDMs demethylate histones 22 5.84e-07 6.15e-01 5.14e-06
SIRT1 negatively regulates rRNA expression 22 5.86e-07 -6.15e-01 5.14e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.11e-04 -6.15e-01 2.18e-03
Influenza Viral RNA Transcription and Replication 135 1.03e-34 -6.12e-01 5.38e-33
Vpu mediated degradation of CD4 39 3.98e-11 -6.11e-01 6.81e-10
Regulation of NPAS4 gene expression 11 4.76e-04 6.08e-01 2.49e-03
Sulfide oxidation to sulfate 5 1.88e-02 -6.07e-01 5.71e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 2.14e-10 -6.03e-01 3.29e-09
Formation of xylulose-5-phosphate 5 1.97e-02 -6.02e-01 5.91e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 2.45e-11 -6.02e-01 4.30e-10
Cellular response to starvation 148 1.06e-36 -6.01e-01 6.23e-35
Proteasome assembly 50 2.03e-13 -6.00e-01 5.03e-12
Folding of actin by CCT/TriC 10 1.03e-03 -5.99e-01 4.93e-03
Cation-coupled Chloride cotransporters 6 1.12e-02 5.98e-01 3.77e-02
Citric acid cycle (TCA cycle) 34 1.64e-09 -5.97e-01 2.21e-08
Mitochondrial iron-sulfur cluster biogenesis 13 2.02e-04 -5.95e-01 1.15e-03
tRNA modification in the mitochondrion 9 2.06e-03 -5.93e-01 8.87e-03
Inhibition of DNA recombination at telomere 33 4.38e-09 -5.90e-01 5.46e-08
MET activates PI3K/AKT signaling 5 2.28e-02 5.88e-01 6.65e-02
Ubiquitin-dependent degradation of Cyclin D 39 2.25e-10 -5.87e-01 3.43e-09
p130Cas linkage to MAPK signaling for integrins 11 7.95e-04 -5.84e-01 3.87e-03
Negative regulation of NOTCH4 signaling 44 2.10e-11 -5.83e-01 3.73e-10
SLBP independent Processing of Histone Pre-mRNAs 10 1.41e-03 -5.83e-01 6.37e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 6.70e-06 -5.82e-01 5.15e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 7.09e-11 -5.81e-01 1.16e-09
TGFBR3 expression 20 6.96e-06 5.80e-01 5.29e-05
Mitochondrial protein degradation 96 8.19e-23 -5.80e-01 3.44e-21
Regulation of Apoptosis 40 2.62e-10 -5.77e-01 3.92e-09
Defective CFTR causes cystic fibrosis 47 7.96e-12 -5.76e-01 1.52e-10
Regulation of ornithine decarboxylase (ODC) 38 7.74e-10 -5.76e-01 1.09e-08
DNA methylation 18 2.46e-05 -5.74e-01 1.63e-04
Hh mutants are degraded by ERAD 42 1.24e-10 -5.74e-01 1.96e-09
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 2.67e-02 -5.72e-01 7.56e-02
Release of apoptotic factors from the mitochondria 6 1.61e-02 -5.67e-01 5.03e-02
Base-Excision Repair, AP Site Formation 29 1.24e-07 -5.67e-01 1.21e-06
RNA Polymerase III Chain Elongation 18 3.13e-05 -5.67e-01 2.06e-04
SCF(Skp2)-mediated degradation of p27/p21 50 4.18e-12 -5.66e-01 8.50e-11
Maturation of spike protein 9683686 5 2.88e-02 -5.64e-01 8.07e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 4.17e-14 -5.64e-01 1.24e-12
APC/C:Cdc20 mediated degradation of Securin 55 5.03e-13 -5.63e-01 1.19e-11
Influenza Infection 154 1.71e-33 -5.62e-01 8.49e-32
Autodegradation of the E3 ubiquitin ligase COP1 38 2.05e-09 -5.62e-01 2.73e-08
Cleavage of the damaged pyrimidine 27 4.37e-07 -5.62e-01 3.93e-06
Depyrimidination 27 4.37e-07 -5.62e-01 3.93e-06
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 4.37e-07 -5.62e-01 3.93e-06
SCF-beta-TrCP mediated degradation of Emi1 42 3.13e-10 -5.61e-01 4.62e-09
Metabolism of polyamines 46 4.99e-11 -5.60e-01 8.45e-10
PINK1-PRKN Mediated Mitophagy 31 6.99e-08 -5.59e-01 7.14e-07
rRNA modification in the nucleus and cytosol 59 1.05e-13 -5.59e-01 2.85e-12
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 4.12e-10 -5.57e-01 5.95e-09
Signaling by RNF43 mutants 7 1.08e-02 5.56e-01 3.67e-02
Hh mutants abrogate ligand secretion 43 3.26e-10 -5.54e-01 4.77e-09
RNA Polymerase I Promoter Escape 45 1.33e-10 -5.53e-01 2.09e-09
Aerobic respiration and respiratory electron transport 245 1.80e-50 -5.53e-01 2.89e-48
Abacavir ADME 5 3.25e-02 5.52e-01 8.86e-02
G2/M DNA replication checkpoint 5 3.28e-02 -5.51e-01 8.91e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 63 4.17e-14 -5.50e-01 1.24e-12
Complex IV assembly 45 1.97e-10 -5.48e-01 3.05e-09
Hedgehog ligand biogenesis 47 8.10e-11 -5.48e-01 1.30e-09
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 1.74e-13 -5.45e-01 4.37e-12
Defective pyroptosis 27 9.86e-07 -5.44e-01 8.46e-06
Defective binding of VWF variant to GPIb:IX:V 7 1.27e-02 -5.44e-01 4.18e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.27e-02 -5.44e-01 4.18e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 5.87e-14 -5.43e-01 1.67e-12
Classical antibody-mediated complement activation 69 7.36e-15 -5.41e-01 2.29e-13
PI3K events in ERBB4 signaling 6 2.24e-02 5.38e-01 6.56e-02
Autodegradation of Cdh1 by Cdh1:APC/C 54 7.89e-12 -5.38e-01 1.52e-10
Zygotic genome activation (ZGA) 5 3.73e-02 5.38e-01 9.86e-02
CD22 mediated BCR regulation 58 1.78e-12 -5.35e-01 3.77e-11
Assembly of the ORC complex at the origin of replication 23 9.29e-06 -5.34e-01 6.88e-05
NADE modulates death signalling 5 3.88e-02 -5.34e-01 1.02e-01
Synthesis of Dolichyl-phosphate 6 2.39e-02 -5.33e-01 6.94e-02
Signaling by ROBO receptors 189 1.93e-36 -5.31e-01 1.09e-34
Cross-presentation of soluble exogenous antigens (endosomes) 35 5.51e-08 -5.31e-01 5.69e-07
CDK-mediated phosphorylation and removal of Cdc6 60 1.44e-12 -5.28e-01 3.14e-11
Synthesis of diphthamide-EEF2 8 9.69e-03 -5.28e-01 3.35e-02
Malate-aspartate shuttle 8 9.95e-03 -5.26e-01 3.43e-02
Calcitonin-like ligand receptors 5 4.18e-02 5.26e-01 1.08e-01
Protein methylation 15 4.65e-04 -5.22e-01 2.43e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 59 5.00e-12 -5.20e-01 1.01e-10
Regulation of Expression and Function of Type II Classical Cadherins 25 6.93e-06 5.19e-01 5.29e-05
Regulation of Homotypic Cell-Cell Adhesion 25 6.93e-06 5.19e-01 5.29e-05
Stabilization of p53 43 3.81e-09 -5.19e-01 4.78e-08
Orc1 removal from chromatin 58 8.29e-12 -5.18e-01 1.57e-10
Replacement of protamines by nucleosomes in the male pronucleus 13 1.21e-03 -5.18e-01 5.66e-03
Regulation of CDH11 Expression and Function 23 1.89e-05 5.15e-01 1.29e-04
Regulation of APC/C activators between G1/S and early anaphase 68 2.10e-13 -5.15e-01 5.14e-12
Creation of C4 and C2 activators 71 6.87e-14 -5.14e-01 1.92e-12
Alpha-oxidation of phytanate 6 2.94e-02 -5.13e-01 8.16e-02
RNA Polymerase III Transcription Termination 23 2.09e-05 -5.12e-01 1.41e-04
NRIF signals cell death from the nucleus 15 5.90e-04 -5.12e-01 2.95e-03
Apoptosis induced DNA fragmentation 10 5.02e-03 -5.12e-01 1.91e-02
Adenylate cyclase activating pathway 8 1.24e-02 5.10e-01 4.11e-02
Scavenging of heme from plasma 70 1.49e-13 -5.10e-01 3.79e-12
Deposition of new CENPA-containing nucleosomes at the centromere 38 5.28e-08 -5.10e-01 5.49e-07
Nucleosome assembly 38 5.28e-08 -5.10e-01 5.49e-07
G2 Phase 5 4.85e-02 -5.10e-01 1.20e-01
Degradation of GLI2 by the proteasome 45 3.34e-09 -5.09e-01 4.24e-08
Purine ribonucleoside monophosphate biosynthesis 9 8.20e-03 -5.09e-01 2.91e-02
Miscellaneous substrates 7 2.03e-02 5.07e-01 6.00e-02
Degradation of DVL 43 9.08e-09 -5.06e-01 1.06e-07
RORA activates gene expression 18 2.06e-04 5.05e-01 1.17e-03
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.84e-05 -5.05e-01 1.27e-04
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.62e-03 -5.05e-01 7.24e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 9.02e-12 -5.05e-01 1.69e-10
Assembly of the pre-replicative complex 87 3.98e-16 -5.04e-01 1.30e-14
G1/S DNA Damage Checkpoints 54 1.90e-10 -5.01e-01 2.97e-09
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.26e-05 -5.00e-01 2.13e-04
Removal of the Flap Intermediate 14 1.19e-03 -5.00e-01 5.58e-03
Regulation of RUNX3 expression and activity 45 6.75e-09 -4.99e-01 8.20e-08
Mitophagy 38 1.17e-07 -4.97e-01 1.14e-06
Formation of the ureteric bud 5 5.69e-02 -4.92e-01 1.35e-01
GLI3 is processed to GLI3R by the proteasome 46 7.93e-09 -4.92e-01 9.45e-08
p53-Dependent G1 DNA Damage Response 52 9.17e-10 -4.91e-01 1.28e-08
p53-Dependent G1/S DNA damage checkpoint 52 9.17e-10 -4.91e-01 1.28e-08
Degradation of AXIN 42 3.84e-08 -4.90e-01 4.12e-07
Displacement of DNA glycosylase by APEX1 9 1.10e-02 -4.90e-01 3.71e-02
Regulation of CDH11 function 10 7.42e-03 4.89e-01 2.68e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.12e-09 -4.88e-01 1.55e-08
DNA Replication Pre-Initiation 103 1.09e-17 -4.88e-01 3.83e-16
Protein hydroxylation 17 4.97e-04 -4.88e-01 2.57e-03
Androgen biosynthesis 5 5.94e-02 -4.87e-01 1.39e-01
Pentose phosphate pathway 13 2.39e-03 -4.86e-01 1.01e-02
CDH11 homotypic and heterotypic interactions 6 3.94e-02 4.86e-01 1.03e-01
rRNA modification in the mitochondrion 8 1.74e-02 -4.86e-01 5.35e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.70e-03 -4.84e-01 7.53e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.29e-06 -4.84e-01 6.88e-05
Ketone body metabolism 8 1.79e-02 -4.83e-01 5.48e-02
Cytosolic tRNA aminoacylation 24 4.27e-05 -4.82e-01 2.74e-04
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 8.92e-05 -4.82e-01 5.27e-04
Initial triggering of complement 79 1.25e-13 -4.82e-01 3.36e-12
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.86e-03 -4.82e-01 1.52e-02
Methionine salvage pathway 6 4.13e-02 -4.81e-01 1.07e-01
Synthesis of Ketone Bodies 6 4.13e-02 -4.81e-01 1.07e-01
NIK–>noncanonical NF-kB signaling 46 1.73e-08 -4.80e-01 1.93e-07
Bicarbonate transporters 9 1.27e-02 4.80e-01 4.18e-02
GDP-fucose biosynthesis 6 4.22e-02 -4.79e-01 1.08e-01
Protein localization 157 3.96e-25 -4.78e-01 1.74e-23
Protein repair 6 4.30e-02 -4.77e-01 1.10e-01
Switching of origins to a post-replicative state 79 2.43e-13 -4.76e-01 5.79e-12
Interconversion of nucleotide di- and triphosphates 27 1.87e-05 -4.76e-01 1.29e-04
APC/C-mediated degradation of cell cycle proteins 75 1.10e-12 -4.75e-01 2.45e-11
Regulation of mitotic cell cycle 75 1.10e-12 -4.75e-01 2.45e-11
PRC2 methylates histones and DNA 27 2.00e-05 -4.74e-01 1.35e-04
Degradation of GLI1 by the proteasome 46 2.62e-08 -4.74e-01 2.84e-07
Glucuronidation 9 1.39e-02 -4.73e-01 4.46e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 4.53e-05 -4.71e-01 2.89e-04
Synthesis of PI 5 6.89e-02 4.70e-01 1.56e-01
VLDLR internalisation and degradation 16 1.15e-03 -4.69e-01 5.42e-03
Josephin domain DUBs 10 1.03e-02 -4.68e-01 3.54e-02
MECP2 regulates transcription of neuronal ligands 5 7.02e-02 4.68e-01 1.58e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 7.49e-03 4.66e-01 2.69e-02
Formation of tubulin folding intermediates by CCT/TriC 21 2.24e-04 -4.65e-01 1.26e-03
Base Excision Repair 57 1.25e-09 -4.65e-01 1.71e-08
Processive synthesis on the lagging strand 15 1.84e-03 -4.65e-01 8.07e-03
CYP2E1 reactions 6 4.89e-02 4.64e-01 1.20e-01
Tandem pore domain potassium channels 5 7.29e-02 4.63e-01 1.62e-01
DNA Replication 128 1.62e-19 -4.62e-01 6.25e-18
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.31e-05 -4.62e-01 1.55e-04
Meiotic recombination 37 1.16e-06 -4.62e-01 9.82e-06
Gap-filling DNA repair synthesis and ligation in GG-NER 25 7.00e-05 -4.59e-01 4.33e-04
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.37e-04 -4.59e-01 7.92e-04
Cohesin Loading onto Chromatin 10 1.21e-02 4.58e-01 4.02e-02
Formation of the active cofactor, UDP-glucuronate 5 7.61e-02 -4.58e-01 1.68e-01
RNA Polymerase I Transcription Termination 30 1.42e-05 -4.58e-01 1.01e-04
Regulation of PTEN localization 9 1.78e-02 -4.56e-01 5.46e-02
Telomere Maintenance 78 3.37e-12 -4.56e-01 6.92e-11
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 6.14e-11 -4.55e-01 1.03e-09
APC-Cdc20 mediated degradation of Nek2A 26 5.94e-05 -4.55e-01 3.73e-04
Synthesis of DNA 108 3.41e-16 -4.54e-01 1.14e-14
Translesion synthesis by REV1 16 1.66e-03 -4.54e-01 7.42e-03
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 5.43e-02 -4.54e-01 1.31e-01
Translesion synthesis by POLI 17 1.23e-03 -4.53e-01 5.71e-03
ABC transporter disorders 60 1.30e-09 -4.53e-01 1.77e-08
ATF6 (ATF6-alpha) activates chaperones 12 6.72e-03 -4.52e-01 2.46e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.83e-03 -4.50e-01 8.05e-03
mRNA decay by 3’ to 5’ exoribonuclease 13 4.98e-03 -4.50e-01 1.90e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 1.39e-02 -4.49e-01 4.46e-02
Dectin-1 mediated noncanonical NF-kB signaling 48 7.30e-08 -4.49e-01 7.42e-07
Metabolism of folate and pterines 16 1.89e-03 -4.48e-01 8.30e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 8.25e-02 4.48e-01 1.79e-01
Nectin/Necl trans heterodimerization 5 8.31e-02 4.47e-01 1.80e-01
Condensation of Prophase Chromosomes 27 5.90e-05 -4.47e-01 3.72e-04
Interleukin-18 signaling 6 5.85e-02 4.46e-01 1.38e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.43e-05 -4.44e-01 4.00e-04
Response to metal ions 6 6.00e-02 -4.43e-01 1.40e-01
Reactions specific to the complex N-glycan synthesis pathway 7 4.26e-02 -4.43e-01 1.09e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 4.29e-02 -4.42e-01 1.10e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 4.63e-06 -4.41e-01 3.62e-05
tRNA Aminoacylation 42 7.51e-07 -4.41e-01 6.51e-06
ATF6 (ATF6-alpha) activates chaperone genes 10 1.58e-02 -4.41e-01 4.97e-02
mRNA Splicing - Minor Pathway 50 7.63e-08 -4.39e-01 7.72e-07
Ubiquinol biosynthesis 13 6.20e-03 -4.38e-01 2.29e-02
Formation of the Early Elongation Complex 33 1.33e-05 -4.38e-01 9.59e-05
Formation of the HIV-1 Early Elongation Complex 33 1.33e-05 -4.38e-01 9.59e-05
Somitogenesis 41 1.25e-06 -4.37e-01 1.05e-05
DNA replication initiation 8 3.24e-02 -4.37e-01 8.86e-02
Mitochondrial tRNA aminoacylation 21 5.34e-04 -4.36e-01 2.73e-03
Mismatch Repair 15 3.57e-03 -4.34e-01 1.43e-02
Metabolism of cofactors 25 1.70e-04 -4.34e-01 9.71e-04
Metabolism of amino acids and derivatives 308 2.36e-39 -4.34e-01 1.63e-37
Inactivation of APC/C via direct inhibition of the APC/C complex 21 5.80e-04 -4.34e-01 2.91e-03
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 5.80e-04 -4.34e-01 2.91e-03
Synthesis of wybutosine at G37 of tRNA(Phe) 6 6.61e-02 -4.33e-01 1.51e-01
Interleukin-15 signaling 14 5.01e-03 4.33e-01 1.90e-02
Regulation of RUNX2 expression and activity 54 3.69e-08 -4.33e-01 3.98e-07
Interleukin-7 signaling 21 5.98e-04 4.33e-01 2.98e-03
RUNX1 regulates estrogen receptor mediated transcription 6 6.71e-02 4.32e-01 1.53e-01
Activated NTRK3 signals through PI3K 5 9.47e-02 4.32e-01 1.97e-01
Translesion synthesis by POLK 17 2.07e-03 -4.31e-01 8.91e-03
Interleukin-6 signaling 11 1.33e-02 4.31e-01 4.34e-02
FLT3 signaling by CBL mutants 7 4.87e-02 -4.30e-01 1.20e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 1.88e-02 -4.29e-01 5.71e-02
Interleukin-9 signaling 8 3.59e-02 4.28e-01 9.56e-02
PCNA-Dependent Long Patch Base Excision Repair 21 6.91e-04 -4.28e-01 3.39e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 5.60e-03 -4.28e-01 2.09e-02
Binding and Uptake of Ligands by Scavenger Receptors 94 8.40e-13 -4.27e-01 1.93e-11
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.95e-02 -4.27e-01 5.87e-02
Asymmetric localization of PCP proteins 49 2.37e-07 -4.27e-01 2.23e-06
Telomere Extension By Telomerase 23 3.98e-04 -4.27e-01 2.12e-03
p75NTR recruits signalling complexes 12 1.07e-02 -4.26e-01 3.64e-02
Recognition of DNA damage by PCNA-containing replication complex 30 5.54e-05 -4.25e-01 3.50e-04
RUNX1 regulates transcription of genes involved in WNT signaling 5 9.98e-02 4.25e-01 2.07e-01
B-WICH complex positively regulates rRNA expression 45 8.65e-07 -4.24e-01 7.46e-06
VEGF binds to VEGFR leading to receptor dimerization 5 1.01e-01 -4.24e-01 2.08e-01
VEGF ligand-receptor interactions 5 1.01e-01 -4.24e-01 2.08e-01
Fatty acids 6 7.23e-02 4.24e-01 1.62e-01
Dual Incision in GG-NER 41 2.66e-06 -4.24e-01 2.15e-05
Budding and maturation of HIV virion 26 1.91e-04 -4.23e-01 1.08e-03
Interleukin receptor SHC signaling 23 4.55e-04 4.22e-01 2.39e-03
Chromosome Maintenance 103 1.42e-13 -4.21e-01 3.72e-12
Metabolism of RNA 718 4.29e-83 -4.21e-01 4.15e-80
MECP2 regulates transcription factors 5 1.03e-01 4.21e-01 2.12e-01
Glutathione conjugation 28 1.24e-04 -4.19e-01 7.23e-04
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.63e-02 -4.18e-01 5.09e-02
FCGR activation 76 2.97e-10 -4.18e-01 4.41e-09
Phosphorylation of the APC/C 20 1.28e-03 -4.16e-01 5.91e-03
Regulation of RAS by GAPs 55 1.06e-07 -4.14e-01 1.04e-06
Defects of platelet adhesion to exposed collagen 8 4.25e-02 -4.14e-01 1.09e-01
TYSND1 cleaves peroxisomal proteins 7 5.86e-02 -4.13e-01 1.38e-01
Regulation of Complement cascade 96 2.96e-12 -4.12e-01 6.14e-11
Cellular response to hypoxia 59 4.72e-08 -4.11e-01 4.98e-07
Regulation of RUNX1 Expression and Activity 18 2.54e-03 4.11e-01 1.06e-02
Vitamin B1 (thiamin) metabolism 5 1.12e-01 -4.10e-01 2.27e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 3.32e-02 -4.10e-01 9.01e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.54e-03 -4.10e-01 1.75e-02
Amyloid fiber formation 52 3.21e-07 -4.10e-01 2.95e-06
Termination of translesion DNA synthesis 32 6.07e-05 -4.10e-01 3.78e-04
Regulation of PTEN stability and activity 55 1.51e-07 -4.09e-01 1.43e-06
Apoptotic factor-mediated response 19 2.03e-03 -4.09e-01 8.77e-03
Defective GALNT3 causes HFTC 9 3.42e-02 4.08e-01 9.16e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.12e-02 -4.06e-01 3.77e-02
Pausing and recovery of Tat-mediated HIV elongation 30 1.19e-04 -4.06e-01 6.93e-04
Tat-mediated HIV elongation arrest and recovery 30 1.19e-04 -4.06e-01 6.93e-04
tRNA modification in the nucleus and cytosol 43 4.10e-06 -4.06e-01 3.26e-05
Processing and activation of SUMO 10 2.64e-02 -4.05e-01 7.51e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 4.76e-02 -4.04e-01 1.18e-01
Formation of TC-NER Pre-Incision Complex 51 5.81e-07 -4.04e-01 5.14e-06
Interleukin-2 signaling 11 2.02e-02 4.04e-01 6.00e-02
Specification of primordial germ cells 6 8.64e-02 4.04e-01 1.85e-01
FCERI mediated NF-kB activation 129 2.30e-15 -4.04e-01 7.39e-14
Pexophagy 10 2.74e-02 -4.03e-01 7.71e-02
NoRC negatively regulates rRNA expression 60 8.61e-08 -3.99e-01 8.53e-07
Negative epigenetic regulation of rRNA expression 63 4.30e-08 -3.99e-01 4.57e-07
Complement cascade 100 5.52e-12 -3.99e-01 1.10e-10
Post-chaperonin tubulin folding pathway 18 3.47e-03 -3.98e-01 1.40e-02
Triglyceride biosynthesis 10 2.96e-02 3.97e-01 8.20e-02
Activation of SMO 13 1.31e-02 3.97e-01 4.29e-02
Regulation of CDH19 Expression and Function 6 9.25e-02 3.97e-01 1.94e-01
Signaling by FLT3 fusion proteins 18 3.59e-03 3.96e-01 1.43e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 3.01e-02 3.96e-01 8.32e-02
MASTL Facilitates Mitotic Progression 10 3.07e-02 -3.95e-01 8.46e-02
Sodium/Proton exchangers 7 7.07e-02 3.94e-01 1.59e-01
Erythrocytes take up oxygen and release carbon dioxide 7 7.10e-02 3.94e-01 1.59e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.37e-02 -3.94e-01 6.90e-02
Diseases of branched-chain amino acid catabolism 13 1.39e-02 -3.94e-01 4.46e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 76 3.00e-09 -3.93e-01 3.89e-08
Glycosphingolipid biosynthesis 15 8.40e-03 3.93e-01 2.96e-02
Removal of the Flap Intermediate from the C-strand 17 5.13e-03 -3.92e-01 1.94e-02
eNOS activation 12 1.89e-02 -3.92e-01 5.71e-02
Signaling by FGFR2 IIIa TM 18 4.05e-03 -3.91e-01 1.59e-02
RHO GTPases activate PKNs 46 4.46e-06 -3.91e-01 3.51e-05
Myogenesis 21 1.94e-03 3.91e-01 8.47e-03
Activation of NF-kappaB in B cells 54 7.23e-07 -3.90e-01 6.30e-06
mRNA Capping 29 2.91e-04 -3.89e-01 1.59e-03
Diseases associated with N-glycosylation of proteins 20 2.65e-03 -3.88e-01 1.10e-02
Phenylalanine and tyrosine metabolism 9 4.40e-02 -3.88e-01 1.12e-01
DNA Damage Recognition in GG-NER 38 3.56e-05 -3.87e-01 2.32e-04
Chromatin modifications during the maternal to zygotic transition (MZT) 23 1.32e-03 -3.87e-01 6.05e-03
Downregulation of ERBB4 signaling 8 5.85e-02 -3.86e-01 1.38e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 4.52e-02 -3.85e-01 1.14e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.73e-04 -3.85e-01 4.24e-03
Adenylate cyclase inhibitory pathway 11 2.72e-02 3.84e-01 7.69e-02
STAT3 nuclear events downstream of ALK signaling 11 2.73e-02 3.84e-01 7.71e-02
Prevention of phagosomal-lysosomal fusion 9 4.61e-02 -3.84e-01 1.15e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.69e-05 -3.84e-01 1.18e-04
HIV Transcription Elongation 42 1.69e-05 -3.84e-01 1.18e-04
Tat-mediated elongation of the HIV-1 transcript 42 1.69e-05 -3.84e-01 1.18e-04
Regulation of MITF-M-dependent genes involved in apoptosis 16 7.98e-03 3.83e-01 2.85e-02
Sema4D mediated inhibition of cell attachment and migration 7 7.95e-02 -3.83e-01 1.74e-01
Regulation of CDH11 gene transcription 5 1.39e-01 3.82e-01 2.63e-01
tRNA processing 128 8.37e-14 -3.82e-01 2.31e-12
Formation of Incision Complex in GG-NER 43 1.47e-05 -3.82e-01 1.05e-04
Adherens junctions interactions 41 2.37e-05 3.81e-01 1.58e-04
Lagging Strand Synthesis 20 3.17e-03 -3.81e-01 1.29e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 6.11e-04 -3.81e-01 3.03e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 6.11e-04 -3.81e-01 3.03e-03
Role of LAT2/NTAL/LAB on calcium mobilization 77 7.77e-09 -3.80e-01 9.38e-08
Degradation of cysteine and homocysteine 13 1.79e-02 -3.79e-01 5.47e-02
Protein lipoylation 10 3.81e-02 -3.79e-01 1.00e-01
Presynaptic depolarization and calcium channel opening 8 6.40e-02 3.78e-01 1.47e-01
Noncanonical activation of NOTCH3 8 6.41e-02 -3.78e-01 1.47e-01
Cyclin E associated events during G1/S transition 73 2.31e-08 -3.78e-01 2.53e-07
Nef Mediated CD4 Down-regulation 9 4.98e-02 -3.78e-01 1.22e-01
Cytosolic iron-sulfur cluster assembly 13 1.86e-02 -3.77e-01 5.68e-02
Interleukin-20 family signaling 17 7.21e-03 3.76e-01 2.61e-02
HIV elongation arrest and recovery 32 2.34e-04 -3.76e-01 1.30e-03
Pausing and recovery of HIV elongation 32 2.34e-04 -3.76e-01 1.30e-03
Physiological factors 9 5.10e-02 3.76e-01 1.25e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.61e-08 -3.75e-01 1.81e-07
FGFR2 alternative splicing 25 1.19e-03 -3.74e-01 5.59e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 2.47e-02 -3.74e-01 7.16e-02
Interleukin-6 family signaling 20 3.76e-03 3.74e-01 1.50e-02
N-glycan trimming and elongation in the cis-Golgi 5 1.48e-01 -3.74e-01 2.76e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 9.77e-03 3.73e-01 3.38e-02
RNA Polymerase I Promoter Clearance 64 2.54e-07 -3.72e-01 2.35e-06
RNA Polymerase I Transcription 64 2.54e-07 -3.72e-01 2.35e-06
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.46e-04 -3.72e-01 3.19e-03
Signaling by FGFR4 in disease 11 3.25e-02 3.72e-01 8.86e-02
Synthesis of GDP-mannose 6 1.14e-01 -3.72e-01 2.30e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 1.00e-02 -3.72e-01 3.43e-02
Signaling by LTK 10 4.18e-02 3.72e-01 1.08e-01
SARS-CoV-1-host interactions 95 3.81e-10 -3.72e-01 5.54e-09
mRNA Splicing 211 1.82e-20 -3.70e-01 7.19e-19
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 9.08e-02 3.69e-01 1.92e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 8.44e-03 -3.69e-01 2.97e-02
Azathioprine ADME 21 3.48e-03 -3.68e-01 1.40e-02
Processive synthesis on the C-strand of the telomere 19 5.45e-03 -3.68e-01 2.04e-02
IkBA variant leads to EDA-ID 7 9.17e-02 3.68e-01 1.93e-01
G2/M Checkpoints 126 1.05e-12 -3.67e-01 2.38e-11
PERK regulates gene expression 30 5.28e-04 -3.66e-01 2.71e-03
Lipophagy 7 9.41e-02 -3.65e-01 1.97e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 9.41e-02 3.65e-01 1.97e-01
Platelet degranulation 106 8.22e-11 -3.65e-01 1.31e-09
Sulfur amino acid metabolism 23 2.46e-03 -3.65e-01 1.04e-02
RUNX3 Regulates Immune Response and Cell Migration 6 1.22e-01 3.64e-01 2.41e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.94e-02 3.63e-01 8.16e-02
G1/S Transition 120 6.23e-12 -3.63e-01 1.23e-10
RNA Polymerase III Transcription Initiation 36 1.63e-04 -3.63e-01 9.29e-04
Diseases of programmed cell death 58 1.73e-06 -3.63e-01 1.42e-05
Formation of HIV elongation complex in the absence of HIV Tat 44 3.14e-05 -3.63e-01 2.06e-04
Purine catabolism 16 1.21e-02 -3.62e-01 4.02e-02
Receptor Mediated Mitophagy 11 3.77e-02 -3.62e-01 9.94e-02
mRNA Splicing - Major Pathway 203 6.36e-19 -3.61e-01 2.41e-17
Signaling by Erythropoietin 24 2.19e-03 3.61e-01 9.37e-03
Class I peroxisomal membrane protein import 20 5.20e-03 -3.61e-01 1.96e-02
Metabolism of nucleotides 85 8.96e-09 -3.61e-01 1.05e-07
Response to elevated platelet cytosolic Ca2+ 110 6.38e-11 -3.60e-01 1.05e-09
Synthesis of PIPs at the ER membrane 5 1.63e-01 3.60e-01 2.94e-01
Translesion Synthesis by POLH 18 8.18e-03 -3.60e-01 2.90e-02
APOBEC3G mediated resistance to HIV-1 infection 5 1.65e-01 -3.59e-01 2.95e-01
Selective autophagy 77 5.19e-08 -3.59e-01 5.45e-07
Resolution of Abasic Sites (AP sites) 38 1.32e-04 -3.58e-01 7.68e-04
p75NTR negatively regulates cell cycle via SC1 5 1.65e-01 -3.58e-01 2.97e-01
Intrinsic Pathway of Fibrin Clot Formation 15 1.65e-02 -3.58e-01 5.13e-02
RNA Polymerase III Abortive And Retractive Initiation 41 7.42e-05 -3.58e-01 4.55e-04
RNA Polymerase III Transcription 41 7.42e-05 -3.58e-01 4.55e-04
Ras activation upon Ca2+ influx through NMDA receptor 18 8.63e-03 3.58e-01 3.03e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.55e-08 -3.57e-01 1.75e-07
Signaling by ALK 24 2.50e-03 3.57e-01 1.05e-02
Wax and plasmalogen biosynthesis 5 1.68e-01 -3.56e-01 2.99e-01
Dual incision in TC-NER 63 1.02e-06 -3.56e-01 8.71e-06
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 9.49e-06 -3.55e-01 7.00e-05
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.66e-03 -3.54e-01 1.10e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.20e-02 3.54e-01 1.08e-01
Nucleotide biosynthesis 12 3.38e-02 -3.54e-01 9.09e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.45e-06 -3.54e-01 1.21e-05
Cyclin A:Cdk2-associated events at S phase entry 75 1.22e-07 -3.53e-01 1.19e-06
DNA Damage/Telomere Stress Induced Senescence 42 7.51e-05 -3.53e-01 4.59e-04
Type I hemidesmosome assembly 8 8.44e-02 3.52e-01 1.82e-01
ER-Phagosome pathway 75 1.47e-07 -3.51e-01 1.40e-06
PCP/CE pathway 75 1.48e-07 -3.51e-01 1.41e-06
Maturation of hRSV A proteins 13 2.87e-02 -3.50e-01 8.05e-02
Alternative complement activation 5 1.75e-01 -3.50e-01 3.10e-01
Heme degradation 11 4.48e-02 -3.49e-01 1.13e-01
Glycogen synthesis 11 4.48e-02 -3.49e-01 1.13e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 9.67e-04 -3.48e-01 4.68e-03
Extension of Telomeres 51 1.73e-05 -3.48e-01 1.21e-04
Regulation of MECP2 expression and activity 29 1.23e-03 3.47e-01 5.71e-03
DNA Damage Reversal 8 8.98e-02 -3.46e-01 1.90e-01
Defective GALNT12 causes CRCS1 9 7.27e-02 3.45e-01 1.62e-01
Condensation of Prometaphase Chromosomes 11 4.73e-02 -3.45e-01 1.17e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 7.76e-03 -3.44e-01 2.78e-02
Ribavirin ADME 11 4.86e-02 -3.43e-01 1.20e-01
Incretin synthesis, secretion, and inactivation 14 2.63e-02 -3.43e-01 7.50e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 2.63e-02 -3.43e-01 7.50e-02
Cytochrome c-mediated apoptotic response 13 3.23e-02 -3.43e-01 8.85e-02
Signaling by NOTCH4 70 7.02e-07 -3.43e-01 6.14e-06
Paracetamol ADME 19 1.00e-02 -3.41e-01 3.44e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 3.33e-02 -3.41e-01 9.01e-02
HIV Transcription Initiation 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II HIV Promoter Escape 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Promoter Escape 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Transcription Initiation 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 7.97e-05 -3.40e-01 4.75e-04
Interleukin-2 family signaling 38 3.02e-04 3.39e-01 1.63e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.51e-01 3.38e-01 2.81e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 1.52e-01 3.38e-01 2.82e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.22e-01 -3.38e-01 2.41e-01
PTK6 Regulates Cell Cycle 6 1.52e-01 -3.38e-01 2.82e-01
Lysosome Vesicle Biogenesis 32 9.98e-04 -3.36e-01 4.81e-03
Activation of the pre-replicative complex 32 1.01e-03 -3.36e-01 4.88e-03
Mitotic Telophase/Cytokinesis 13 3.63e-02 3.35e-01 9.64e-02
Aryl hydrocarbon receptor signalling 6 1.56e-01 -3.34e-01 2.85e-01
HDL assembly 6 1.56e-01 3.34e-01 2.85e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 3.84e-03 -3.34e-01 1.52e-02
Nef and signal transduction 8 1.03e-01 3.33e-01 2.11e-01
Glycosphingolipid catabolism 31 1.32e-03 -3.33e-01 6.06e-03
Peroxisomal protein import 58 1.13e-05 -3.33e-01 8.33e-05
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.46e-02 -3.33e-01 4.62e-02
FGFR2 mutant receptor activation 23 5.90e-03 -3.32e-01 2.19e-02
Leading Strand Synthesis 14 3.17e-02 -3.32e-01 8.69e-02
Polymerase switching 14 3.17e-02 -3.32e-01 8.69e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 2.01e-03 -3.31e-01 8.77e-03
The activation of arylsulfatases 10 6.97e-02 -3.31e-01 1.57e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.80e-02 -3.30e-01 1.19e-01
Inactivation of CDC42 and RAC1 7 1.31e-01 -3.29e-01 2.54e-01
Nucleotide Excision Repair 108 3.42e-09 -3.29e-01 4.32e-08
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 1.32e-01 3.29e-01 2.55e-01
RNA Polymerase II Transcription Termination 66 3.99e-06 -3.28e-01 3.18e-05
Senescence-Associated Secretory Phenotype (SASP) 65 4.75e-06 -3.28e-01 3.70e-05
Recycling of bile acids and salts 10 7.26e-02 3.28e-01 1.62e-01
PI3K events in ERBB2 signaling 11 5.98e-02 3.28e-01 1.39e-01
DNA strand elongation 32 1.35e-03 -3.27e-01 6.17e-03
Processing of Capped Intron-Containing Pre-mRNA 279 5.48e-21 -3.27e-01 2.25e-19
NOTCH2 intracellular domain regulates transcription 11 6.07e-02 3.27e-01 1.41e-01
Branched-chain amino acid catabolism 21 9.57e-03 -3.27e-01 3.33e-02
Advanced glycosylation endproduct receptor signaling 12 5.03e-02 -3.26e-01 1.23e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 1.67e-02 3.26e-01 5.19e-02
Aggrephagy 34 1.02e-03 -3.25e-01 4.91e-03
SHC-related events triggered by IGF1R 8 1.11e-01 3.25e-01 2.25e-01
ABC-family proteins mediated transport 81 4.18e-07 -3.25e-01 3.81e-06
Transcription of the HIV genome 67 4.16e-06 -3.25e-01 3.30e-05
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.28e-04 -3.25e-01 2.71e-03
Urea cycle 7 1.37e-01 -3.25e-01 2.60e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 3.22e-07 -3.24e-01 2.95e-06
Disorders of Developmental Biology 12 5.22e-02 3.24e-01 1.26e-01
Disorders of Nervous System Development 12 5.22e-02 3.24e-01 1.26e-01
Loss of function of MECP2 in Rett syndrome 12 5.22e-02 3.24e-01 1.26e-01
Pervasive developmental disorders 12 5.22e-02 3.24e-01 1.26e-01
Signaling by BMP 23 7.28e-03 3.23e-01 2.64e-02
Regulation of gene expression in beta cells 8 1.14e-01 3.23e-01 2.30e-01
Mitotic G1 phase and G1/S transition 138 6.22e-11 -3.22e-01 1.04e-09
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 1.41e-01 3.21e-01 2.67e-01
Transport of nucleotide sugars 9 9.57e-02 -3.21e-01 1.99e-01
DCC mediated attractive signaling 13 4.54e-02 -3.20e-01 1.14e-01
Vitamin C (ascorbate) metabolism 8 1.17e-01 3.20e-01 2.33e-01
Positive epigenetic regulation of rRNA expression 60 1.82e-05 -3.20e-01 1.26e-04
E3 ubiquitin ligases ubiquitinate target proteins 51 7.77e-05 -3.20e-01 4.73e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.06e-03 -3.20e-01 5.07e-03
Role of phospholipids in phagocytosis 88 2.27e-07 -3.19e-01 2.14e-06
Interleukin-10 signaling 38 6.67e-04 3.19e-01 3.28e-03
Diseases of Mismatch Repair (MMR) 5 2.17e-01 -3.19e-01 3.61e-01
Late endosomal microautophagy 30 2.55e-03 -3.18e-01 1.06e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.45e-01 3.18e-01 2.73e-01
S Phase 150 1.77e-11 -3.18e-01 3.17e-10
RHO GTPases Activate Rhotekin and Rhophilins 8 1.20e-01 -3.17e-01 2.38e-01
Activation of BAD and translocation to mitochondria 15 3.33e-02 -3.17e-01 9.01e-02
FCERI mediated MAPK activation 93 1.44e-07 -3.15e-01 1.39e-06
Defective factor IX causes hemophilia B 6 1.82e-01 -3.15e-01 3.18e-01
Processing of Capped Intronless Pre-mRNA 29 3.34e-03 -3.15e-01 1.36e-02
Propionyl-CoA catabolism 5 2.24e-01 -3.14e-01 3.70e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.52e-02 -3.14e-01 7.25e-02
Chaperone Mediated Autophagy 20 1.55e-02 -3.12e-01 4.88e-02
Axonal growth inhibition (RHOA activation) 7 1.53e-01 -3.12e-01 2.83e-01
p75NTR regulates axonogenesis 7 1.53e-01 -3.12e-01 2.83e-01
Nuclear events mediated by NFE2L2 82 1.02e-06 -3.12e-01 8.71e-06
FCGR3A-mediated phagocytosis 121 3.02e-09 -3.12e-01 3.89e-08
Leishmania phagocytosis 121 3.02e-09 -3.12e-01 3.89e-08
Parasite infection 121 3.02e-09 -3.12e-01 3.89e-08
Signaling by WNT in cancer 30 3.10e-03 3.12e-01 1.27e-02
Myoclonic epilepsy of Lafora 8 1.27e-01 -3.12e-01 2.48e-01
Regulation of IFNA/IFNB signaling 12 6.21e-02 3.11e-01 1.43e-01
Cell Cycle Checkpoints 246 4.19e-17 -3.11e-01 1.42e-15
NFE2L2 regulating ER-stress associated genes 5 2.29e-01 3.11e-01 3.75e-01
SMAC (DIABLO) binds to IAPs 7 1.55e-01 -3.11e-01 2.84e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.55e-01 -3.11e-01 2.84e-01
SMAC, XIAP-regulated apoptotic response 7 1.55e-01 -3.11e-01 2.84e-01
HIV Infection 213 5.49e-15 -3.10e-01 1.74e-13
UCH proteinases 73 4.52e-06 -3.10e-01 3.55e-05
NF-kB is activated and signals survival 12 6.28e-02 -3.10e-01 1.45e-01
ABC transporters in lipid homeostasis 14 4.48e-02 3.10e-01 1.13e-01
Heme signaling 45 3.38e-04 3.09e-01 1.81e-03
Signaling by the B Cell Receptor (BCR) 150 7.65e-11 -3.08e-01 1.24e-09
Insulin receptor recycling 24 9.09e-03 -3.08e-01 3.18e-02
Aflatoxin activation and detoxification 14 4.67e-02 -3.07e-01 1.16e-01
Pregnenolone biosynthesis 10 9.28e-02 -3.07e-01 1.94e-01
Diseases associated with glycosylation precursor biosynthesis 15 3.96e-02 -3.07e-01 1.03e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 1.60e-01 3.07e-01 2.91e-01
Early Phase of HIV Life Cycle 14 4.71e-02 -3.06e-01 1.17e-01
Host Interactions of HIV factors 118 9.28e-09 -3.06e-01 1.07e-07
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.91e-02 -3.06e-01 8.14e-02
SARS-CoV-1 Infection 138 6.00e-10 -3.05e-01 8.53e-09
DNA Damage Bypass 47 2.96e-04 -3.05e-01 1.61e-03
Polo-like kinase mediated events 16 3.47e-02 -3.05e-01 9.28e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.14e-01 -3.04e-01 2.30e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 2.39e-01 -3.04e-01 3.90e-01
Retrograde neurotrophin signalling 12 6.95e-02 -3.03e-01 1.57e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 9.77e-02 3.02e-01 2.02e-01
FCERI mediated Ca+2 mobilization 92 5.45e-07 -3.02e-01 4.86e-06
Germ layer formation at gastrulation 9 1.17e-01 3.02e-01 2.33e-01
O-glycosylation of TSR domain-containing proteins 28 5.75e-03 3.02e-01 2.14e-02
Separation of Sister Chromatids 168 1.53e-11 -3.01e-01 2.76e-10
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.44e-01 3.01e-01 3.95e-01
Mitotic Anaphase 211 4.81e-14 -3.01e-01 1.40e-12
Metabolism of nitric oxide: NOS3 activation and regulation 15 4.40e-02 -3.00e-01 1.12e-01
Signal transduction by L1 20 2.01e-02 -3.00e-01 5.98e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 5.18e-02 -3.00e-01 1.26e-01
Mitotic Metaphase and Anaphase 212 4.86e-14 -3.00e-01 1.40e-12
Macroautophagy 128 5.30e-09 -2.99e-01 6.57e-08
Spry regulation of FGF signaling 16 3.87e-02 -2.99e-01 1.01e-01
Defective B3GALTL causes PpS 27 7.37e-03 2.98e-01 2.66e-02
Prostanoid ligand receptors 8 1.45e-01 -2.98e-01 2.72e-01
Nucleotide catabolism 28 6.45e-03 -2.97e-01 2.37e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 4.64e-02 2.97e-01 1.16e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.08e-01 2.97e-01 3.49e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 2.08e-01 -2.97e-01 3.49e-01
Estrogen-stimulated signaling through PRKCZ 6 2.08e-01 -2.97e-01 3.49e-01
Pyrimidine salvage 10 1.05e-01 -2.96e-01 2.15e-01
Transport of RCbl within the body 8 1.47e-01 -2.96e-01 2.76e-01
Beta-oxidation of pristanoyl-CoA 9 1.24e-01 -2.96e-01 2.44e-01
RUNX3 regulates NOTCH signaling 14 5.56e-02 2.95e-01 1.33e-01
IRAK1 recruits IKK complex 14 5.67e-02 -2.94e-01 1.35e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 5.67e-02 -2.94e-01 1.35e-01
Initiation of Nuclear Envelope (NE) Reformation 19 2.65e-02 -2.94e-01 7.54e-02
Reversal of alkylation damage by DNA dioxygenases 7 1.79e-01 -2.93e-01 3.15e-01
RHOBTB1 GTPase cycle 23 1.49e-02 -2.93e-01 4.69e-02
Regulation of actin dynamics for phagocytic cup formation 123 1.91e-08 -2.93e-01 2.12e-07
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 5.45e-03 -2.93e-01 2.04e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 2.02e-02 -2.93e-01 6.00e-02
Neurodegenerative Diseases 21 2.02e-02 -2.93e-01 6.00e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 4.27e-03 -2.92e-01 1.66e-02
RAS processing 23 1.55e-02 -2.92e-01 4.87e-02
Nef Mediated CD8 Down-regulation 7 1.82e-01 -2.92e-01 3.18e-01
Activation of caspases through apoptosome-mediated cleavage 6 2.17e-01 -2.91e-01 3.60e-01
Regulation of BACH1 activity 11 9.44e-02 -2.91e-01 1.97e-01
Glutathione synthesis and recycling 10 1.11e-01 -2.91e-01 2.25e-01
Transcriptional regulation of pluripotent stem cells 21 2.13e-02 2.90e-01 6.26e-02
E2F-enabled inhibition of pre-replication complex formation 9 1.33e-01 -2.89e-01 2.57e-01
CD209 (DC-SIGN) signaling 20 2.53e-02 2.89e-01 7.25e-02
Activation of Ca-permeable Kainate Receptor 9 1.34e-01 2.88e-01 2.57e-01
Ionotropic activity of kainate receptors 9 1.34e-01 2.88e-01 2.57e-01
Downstream signaling events of B Cell Receptor (BCR) 68 4.02e-05 -2.88e-01 2.60e-04
HCMV Late Events 67 4.69e-05 -2.88e-01 2.98e-04
GP1b-IX-V activation signalling 12 8.51e-02 -2.87e-01 1.83e-01
Regulation of innate immune responses to cytosolic DNA 14 6.31e-02 -2.87e-01 1.45e-01
Nuclear Envelope (NE) Reassembly 68 4.46e-05 -2.86e-01 2.85e-04
Transcriptional regulation of testis differentiation 5 2.68e-01 2.86e-01 4.22e-01
Formation of paraxial mesoderm 52 3.72e-04 -2.85e-01 1.99e-03
Membrane binding and targetting of GAG proteins 13 7.51e-02 -2.85e-01 1.66e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 7.51e-02 -2.85e-01 1.66e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.37e-02 2.85e-01 4.41e-02
Late Phase of HIV Life Cycle 131 2.00e-08 -2.84e-01 2.21e-07
Telomere C-strand (Lagging Strand) Synthesis 34 4.26e-03 -2.83e-01 1.66e-02
TNFR1-mediated ceramide production 6 2.30e-01 -2.83e-01 3.77e-01
Transcriptional regulation by small RNAs 61 1.35e-04 -2.83e-01 7.81e-04
Activation of RAS in B cells 5 2.74e-01 2.83e-01 4.29e-01
mTORC1-mediated signalling 24 1.67e-02 -2.82e-01 5.19e-02
Interaction between L1 and Ankyrins 26 1.28e-02 2.82e-01 4.20e-02
Smooth Muscle Contraction 34 4.45e-03 -2.82e-01 1.72e-02
Viral Infection Pathways 776 7.78e-41 -2.82e-01 6.83e-39
HIV Life Cycle 144 5.41e-09 -2.82e-01 6.66e-08
Regulation of PTEN mRNA translation 13 7.89e-02 2.81e-01 1.73e-01
Nuclear Receptor transcription pathway 40 2.08e-03 2.81e-01 8.91e-03
MyD88 deficiency (TLR2/4) 14 6.86e-02 2.81e-01 1.56e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 6.87e-02 -2.81e-01 1.56e-01
Phase 4 - resting membrane potential 9 1.44e-01 2.81e-01 2.72e-01
Diseases of Base Excision Repair 5 2.78e-01 -2.80e-01 4.34e-01
Cholesterol biosynthesis 26 1.36e-02 -2.80e-01 4.39e-02
Acetylcholine binding and downstream events 5 2.79e-01 2.80e-01 4.34e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.79e-01 2.80e-01 4.34e-01
Infection with Mycobacterium tuberculosis 26 1.39e-02 -2.79e-01 4.46e-02
Autophagy 142 9.69e-09 -2.79e-01 1.11e-07
mRNA 3’-end processing 57 2.79e-04 -2.78e-01 1.53e-03
Assembly Of The HIV Virion 15 6.21e-02 -2.78e-01 1.43e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 1.43e-03 2.78e-01 6.45e-03
Cyclin A/B1/B2 associated events during G2/M transition 25 1.62e-02 -2.78e-01 5.08e-02
Voltage gated Potassium channels 26 1.45e-02 2.77e-01 4.60e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.21e-02 -2.77e-01 8.80e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 9.70e-02 -2.77e-01 2.01e-01
Metabolism of non-coding RNA 53 4.97e-04 -2.76e-01 2.57e-03
snRNP Assembly 53 4.97e-04 -2.76e-01 2.57e-03
2-LTR circle formation 7 2.05e-01 -2.76e-01 3.48e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 6.01e-03 2.76e-01 2.22e-02
TRAIL signaling 8 1.76e-01 2.76e-01 3.11e-01
Synaptic adhesion-like molecules 17 4.90e-02 2.76e-01 1.21e-01
TRP channels 22 2.54e-02 2.75e-01 7.26e-02
Protein ubiquitination 71 6.05e-05 -2.75e-01 3.78e-04
Cellular responses to stress 698 2.47e-35 -2.75e-01 1.33e-33
Transport of vitamins, nucleosides, and related molecules 32 7.18e-03 -2.75e-01 2.61e-02
Interleukin-1 processing 8 1.79e-01 2.74e-01 3.15e-01
SARS-CoV-2 modulates autophagy 11 1.16e-01 -2.74e-01 2.32e-01
NFE2L2 regulating tumorigenic genes 11 1.16e-01 2.74e-01 2.32e-01
Protein folding 83 1.67e-05 -2.73e-01 1.18e-04
Transcriptional Regulation by NPAS4 27 1.40e-02 2.73e-01 4.47e-02
Antigen processing-Cross presentation 89 8.68e-06 -2.73e-01 6.50e-05
Defective Intrinsic Pathway for Apoptosis 24 2.08e-02 -2.73e-01 6.14e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 1.57e-01 2.72e-01 2.87e-01
Negative feedback regulation of MAPK pathway 6 2.50e-01 -2.71e-01 4.02e-01
Processing of DNA double-strand break ends 69 1.00e-04 -2.71e-01 5.89e-04
Caspase activation via Death Receptors in the presence of ligand 16 6.14e-02 2.70e-01 1.42e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.06e-06 -2.69e-01 1.68e-05
Defective C1GALT1C1 causes TNPS 10 1.41e-01 2.69e-01 2.67e-01
EGFR interacts with phospholipase C-gamma 7 2.18e-01 2.69e-01 3.62e-01
Integration of provirus 9 1.63e-01 -2.69e-01 2.94e-01
Regulation of beta-cell development 22 2.92e-02 2.69e-01 8.16e-02
MECP2 regulates neuronal receptors and channels 14 8.23e-02 2.68e-01 1.79e-01
Degradation of beta-catenin by the destruction complex 72 8.50e-05 -2.68e-01 5.05e-04
Phase II - Conjugation of compounds 71 9.63e-05 -2.68e-01 5.67e-04
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.10e-01 -2.67e-01 2.23e-01
Transport of connexons to the plasma membrane 12 1.10e-01 -2.67e-01 2.23e-01
Amine ligand-binding receptors 10 1.44e-01 2.67e-01 2.72e-01
Diseases associated with the TLR signaling cascade 29 1.30e-02 2.67e-01 4.24e-02
Diseases of Immune System 29 1.30e-02 2.67e-01 4.24e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.93e-01 -2.66e-01 3.33e-01
Syndecan interactions 26 1.94e-02 -2.65e-01 5.86e-02
Formation of apoptosome 11 1.29e-01 -2.65e-01 2.50e-01
Regulation of the apoptosome activity 11 1.29e-01 -2.65e-01 2.50e-01
Neurexins and neuroligins 40 3.81e-03 2.64e-01 1.51e-02
Synthesis of PIPs at the plasma membrane 52 9.75e-04 2.64e-01 4.71e-03
Homology Directed Repair 110 1.67e-06 -2.64e-01 1.38e-05
Polymerase switching on the C-strand of the telomere 26 1.99e-02 -2.64e-01 5.95e-02
Glyoxylate metabolism and glycine degradation 13 1.00e-01 -2.63e-01 2.07e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.65e-01 -2.63e-01 4.19e-01
IL-6-type cytokine receptor ligand interactions 13 1.03e-01 2.61e-01 2.12e-01
Platelet Aggregation (Plug Formation) 30 1.33e-02 -2.61e-01 4.34e-02
Scavenging by Class A Receptors 14 9.11e-02 -2.61e-01 1.92e-01
HCMV Infection 106 3.81e-06 -2.60e-01 3.06e-05
TRAF3-dependent IRF activation pathway 13 1.05e-01 2.60e-01 2.15e-01
LGI-ADAM interactions 9 1.78e-01 2.60e-01 3.13e-01
Fructose catabolism 5 3.15e-01 -2.59e-01 4.71e-01
Suppression of phagosomal maturation 12 1.20e-01 -2.59e-01 2.38e-01
Signaling by MST1 5 3.17e-01 -2.58e-01 4.72e-01
Amino acids regulate mTORC1 48 1.98e-03 -2.58e-01 8.64e-03
CLEC7A (Dectin-1) induces NFAT activation 11 1.39e-01 2.58e-01 2.64e-01
Metabolism of proteins 1777 7.45e-73 -2.57e-01 4.80e-70
IRAK4 deficiency (TLR2/4) 15 8.55e-02 2.56e-01 1.84e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.09e-01 2.56e-01 3.50e-01
Regulation of signaling by CBL 22 3.77e-02 2.56e-01 9.95e-02
Metabolism of porphyrins 23 3.37e-02 -2.56e-01 9.08e-02
Activation of NOXA and translocation to mitochondria 5 3.22e-01 2.56e-01 4.78e-01
Cellular responses to stimuli 779 5.49e-34 -2.56e-01 2.79e-32
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.62e-01 -2.55e-01 2.94e-01
TGFBR3 PTM regulation 10 1.63e-01 -2.55e-01 2.94e-01
Association of TriC/CCT with target proteins during biosynthesis 35 9.12e-03 -2.55e-01 3.18e-02
Maturation of spike protein 9694548 36 8.27e-03 -2.54e-01 2.93e-02
PTK6 promotes HIF1A stabilization 6 2.82e-01 2.54e-01 4.36e-01
Phosphorylation of Emi1 6 2.82e-01 -2.54e-01 4.36e-01
trans-Golgi Network Vesicle Budding 69 2.67e-04 -2.54e-01 1.48e-03
tRNA processing in the nucleus 59 7.72e-04 -2.53e-01 3.76e-03
KEAP1-NFE2L2 pathway 107 6.10e-06 -2.53e-01 4.72e-05
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 2.47e-01 2.53e-01 3.98e-01
Fc epsilon receptor (FCERI) signaling 179 5.58e-09 -2.52e-01 6.83e-08
Cell surface interactions at the vascular wall 176 8.02e-09 -2.52e-01 9.50e-08
Methylation 13 1.16e-01 -2.52e-01 2.32e-01
Activation of RAC1 downstream of NMDARs 7 2.49e-01 -2.52e-01 4.01e-01
Signaling by ERBB2 KD Mutants 20 5.15e-02 2.51e-01 1.26e-01
Transcriptional regulation by RUNX2 92 3.07e-05 -2.51e-01 2.03e-04
Formation of axial mesoderm 6 2.87e-01 2.51e-01 4.42e-01
Unfolded Protein Response (UPR) 84 7.02e-05 -2.51e-01 4.33e-04
NFE2L2 regulates pentose phosphate pathway genes 8 2.20e-01 2.51e-01 3.64e-01
MicroRNA (miRNA) biogenesis 24 3.37e-02 -2.50e-01 9.08e-02
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 3.33e-01 -2.50e-01 4.90e-01
MAPK6/MAPK4 signaling 69 3.32e-04 -2.50e-01 1.79e-03
Ca2+ activated K+ channels 6 2.90e-01 -2.50e-01 4.45e-01
RMTs methylate histone arginines 35 1.06e-02 -2.49e-01 3.63e-02
TNFR2 non-canonical NF-kB pathway 84 7.79e-05 -2.49e-01 4.73e-04
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.36e-01 2.49e-01 2.59e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 8.51e-02 -2.49e-01 1.83e-01
TNFR1-induced proapoptotic signaling 24 3.53e-02 2.48e-01 9.40e-02
Chondroitin sulfate biosynthesis 12 1.37e-01 2.48e-01 2.60e-01
FCGR3A-mediated IL10 synthesis 99 1.98e-05 -2.48e-01 1.35e-04
Nucleotide salvage 21 4.91e-02 -2.48e-01 1.21e-01
HDR through Homologous Recombination (HRR) 68 4.05e-04 -2.48e-01 2.15e-03
Activation of ATR in response to replication stress 37 9.07e-03 -2.48e-01 3.18e-02
CASP8 activity is inhibited 11 1.55e-01 2.48e-01 2.84e-01
Dimerization of procaspase-8 11 1.55e-01 2.48e-01 2.84e-01
Regulation by c-FLIP 11 1.55e-01 2.48e-01 2.84e-01
Diseases of hemostasis 15 9.69e-02 -2.48e-01 2.01e-01
G1/S-Specific Transcription 29 2.12e-02 -2.47e-01 6.25e-02
Mitotic G2-G2/M phases 179 1.17e-08 -2.47e-01 1.34e-07
NrCAM interactions 6 2.95e-01 2.47e-01 4.51e-01
PI-3K cascade:FGFR4 11 1.56e-01 2.47e-01 2.85e-01
Calnexin/calreticulin cycle 26 2.93e-02 -2.47e-01 8.16e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.10e-01 -2.47e-01 2.23e-01
Miro GTPase Cycle 8 2.27e-01 -2.47e-01 3.74e-01
CREB3 factors activate genes 6 2.98e-01 -2.46e-01 4.54e-01
G2/M DNA damage checkpoint 66 5.67e-04 -2.45e-01 2.88e-03
Negative regulation of FGFR3 signaling 21 5.18e-02 -2.45e-01 1.26e-01
Diseases associated with O-glycosylation of proteins 50 2.79e-03 2.44e-01 1.15e-02
HSF1 activation 26 3.13e-02 -2.44e-01 8.60e-02
NCAM1 interactions 27 2.85e-02 2.44e-01 8.00e-02
Endosomal/Vacuolar pathway 12 1.44e-01 -2.43e-01 2.72e-01
G2/M Transition 177 2.35e-08 -2.43e-01 2.56e-07
p75NTR signals via NF-kB 15 1.03e-01 -2.43e-01 2.12e-01
Chaperonin-mediated protein folding 77 2.28e-04 -2.43e-01 1.28e-03
Signaling by NTRK3 (TRKC) 16 9.27e-02 2.43e-01 1.94e-01
Defects in biotin (Btn) metabolism 8 2.34e-01 -2.43e-01 3.84e-01
RNA Polymerase II Pre-transcription Events 77 2.39e-04 -2.42e-01 1.33e-03
Long-term potentiation 18 7.60e-02 2.42e-01 1.68e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.22e-02 2.41e-01 6.49e-02
DNA Repair 289 1.72e-12 -2.41e-01 3.69e-11
PI-3K cascade:FGFR2 13 1.34e-01 2.40e-01 2.57e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 9.43e-03 2.40e-01 3.28e-02
Mitotic Spindle Checkpoint 108 1.67e-05 -2.40e-01 1.18e-04
RHOBTB GTPase Cycle 35 1.42e-02 -2.40e-01 4.51e-02
Infectious disease 959 2.86e-36 -2.39e-01 1.58e-34
ZBP1(DAI) mediated induction of type I IFNs 20 6.43e-02 2.39e-01 1.47e-01
Deadenylation-dependent mRNA decay 50 3.49e-03 -2.39e-01 1.40e-02
Role of second messengers in netrin-1 signaling 6 3.12e-01 2.39e-01 4.69e-01
Class B/2 (Secretin family receptors) 55 2.22e-03 2.38e-01 9.46e-03
Thyroxine biosynthesis 5 3.56e-01 2.38e-01 5.14e-01
Interleukin-37 signaling 19 7.21e-02 2.38e-01 1.61e-01
Detoxification of Reactive Oxygen Species 30 2.39e-02 -2.38e-01 6.94e-02
MAP2K and MAPK activation 36 1.34e-02 -2.38e-01 4.35e-02
Diseases of carbohydrate metabolism 29 2.66e-02 -2.38e-01 7.54e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.24e-01 2.37e-01 2.44e-01
Unwinding of DNA 12 1.55e-01 -2.37e-01 2.84e-01
Sphingolipid de novo biosynthesis 34 1.68e-02 -2.37e-01 5.21e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.54e-03 -2.37e-01 1.75e-02
COPI-independent Golgi-to-ER retrograde traffic 45 6.13e-03 -2.36e-01 2.26e-02
Pyruvate metabolism 44 6.74e-03 -2.36e-01 2.46e-02
Regulation of HMOX1 expression and activity 5 3.61e-01 2.36e-01 5.19e-01
Formation of RNA Pol II elongation complex 56 2.28e-03 -2.36e-01 9.70e-03
RNA Polymerase II Transcription Elongation 56 2.28e-03 -2.36e-01 9.70e-03
RUNX3 regulates p14-ARF 10 1.97e-01 2.36e-01 3.39e-01
Nephrin family interactions 20 6.82e-02 2.36e-01 1.55e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 5.06e-02 -2.35e-01 1.24e-01
Neddylation 215 2.66e-09 -2.35e-01 3.51e-08
RNA Polymerase I Transcription Initiation 47 5.28e-03 -2.35e-01 1.99e-02
SHC1 events in ERBB4 signaling 10 1.98e-01 2.35e-01 3.39e-01
Phase 0 - rapid depolarisation 24 4.66e-02 2.35e-01 1.16e-01
WNT5A-dependent internalization of FZD4 13 1.43e-01 -2.35e-01 2.70e-01
Expression and translocation of olfactory receptors 56 2.39e-03 2.35e-01 1.01e-02
Cell-cell junction organization 60 1.68e-03 2.34e-01 7.47e-03
PI Metabolism 79 3.14e-04 2.34e-01 1.70e-03
Transport of Mature Transcript to Cytoplasm 81 2.71e-04 -2.34e-01 1.49e-03
Sodium/Calcium exchangers 9 2.26e-01 -2.33e-01 3.72e-01
Fructose metabolism 7 2.89e-01 -2.32e-01 4.45e-01
Intrinsic Pathway for Apoptosis 54 3.31e-03 -2.31e-01 1.35e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.10e-01 -2.31e-01 2.23e-01
NFE2L2 regulating MDR associated enzymes 8 2.58e-01 2.31e-01 4.10e-01
Signaling by high-kinase activity BRAF mutants 33 2.17e-02 -2.31e-01 6.38e-02
BBSome-mediated cargo-targeting to cilium 22 6.12e-02 -2.31e-01 1.42e-01
Downstream signaling of activated FGFR4 18 9.12e-02 2.30e-01 1.92e-01
Hyaluronan uptake and degradation 12 1.68e-01 -2.30e-01 3.00e-01
Meiosis 67 1.14e-03 -2.30e-01 5.40e-03
Xenobiotics 12 1.69e-01 2.30e-01 3.00e-01
Gluconeogenesis 19 8.33e-02 -2.29e-01 1.80e-01
Downstream signaling of activated FGFR1 22 6.26e-02 2.29e-01 1.44e-01
DNA Double-Strand Break Repair 137 3.60e-06 -2.29e-01 2.90e-05
Transcriptional Regulation by MECP2 49 5.52e-03 2.29e-01 2.07e-02
HCMV Early Events 84 2.83e-04 -2.29e-01 1.55e-03
M Phase 346 2.39e-13 -2.29e-01 5.78e-12
TP53 Regulates Metabolic Genes 78 4.87e-04 -2.28e-01 2.54e-03
Synthesis of bile acids and bile salts 27 4.05e-02 2.28e-01 1.06e-01
Insulin processing 19 8.59e-02 2.28e-01 1.84e-01
Bile acid and bile salt metabolism 31 2.85e-02 2.27e-01 8.00e-02
Downstream signaling of activated FGFR2 20 7.85e-02 2.27e-01 1.72e-01
Basigin interactions 23 5.94e-02 -2.27e-01 1.39e-01
Downstream TCR signaling 89 2.17e-04 -2.27e-01 1.22e-03
Translation of Structural Proteins 9694635 56 3.37e-03 -2.26e-01 1.37e-02
Dissolution of Fibrin Clot 12 1.75e-01 -2.26e-01 3.09e-01
Linoleic acid (LA) metabolism 7 3.01e-01 2.26e-01 4.59e-01
SARS-CoV-2-host interactions 183 1.39e-07 -2.26e-01 1.34e-06
RIP-mediated NFkB activation via ZBP1 17 1.07e-01 2.26e-01 2.19e-01
Termination of O-glycan biosynthesis 16 1.19e-01 2.25e-01 2.36e-01
Synthesis of PIPs at the early endosome membrane 16 1.19e-01 2.25e-01 2.36e-01
PI-3K cascade:FGFR3 10 2.18e-01 2.25e-01 3.62e-01
Peroxisomal lipid metabolism 27 4.31e-02 -2.25e-01 1.10e-01
Anti-inflammatory response favouring Leishmania parasite infection 132 8.12e-06 -2.25e-01 6.13e-05
Leishmania parasite growth and survival 132 8.12e-06 -2.25e-01 6.13e-05
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 4.72e-02 2.25e-01 1.17e-01
ROBO receptors bind AKAP5 7 3.03e-01 2.25e-01 4.60e-01
Olfactory Signaling Pathway 61 2.42e-03 2.25e-01 1.02e-02
Signaling by LTK in cancer 7 3.04e-01 2.24e-01 4.61e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.86e-01 2.24e-01 5.45e-01
MHC class II antigen presentation 113 3.89e-05 -2.24e-01 2.52e-04
Lysosphingolipid and LPA receptors 11 1.99e-01 2.24e-01 3.40e-01
DNA Double Strand Break Response 47 8.06e-03 -2.23e-01 2.87e-02
GAB1 signalosome 15 1.35e-01 2.23e-01 2.59e-01
Dectin-2 family 19 9.28e-02 2.23e-01 1.94e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 3.89e-01 -2.23e-01 5.47e-01
Maple Syrup Urine Disease 5 3.89e-01 -2.23e-01 5.47e-01
RHOBTB3 ATPase cycle 10 2.24e-01 -2.22e-01 3.70e-01
Platelet Adhesion to exposed collagen 16 1.25e-01 -2.22e-01 2.45e-01
Coenzyme A biosynthesis 7 3.10e-01 -2.21e-01 4.67e-01
Neurotransmitter clearance 6 3.48e-01 -2.21e-01 5.06e-01
GABA receptor activation 38 1.83e-02 2.21e-01 5.59e-02
NR1H2 and NR1H3-mediated signaling 39 1.71e-02 2.21e-01 5.28e-02
Metabolism 1835 1.10e-55 -2.21e-01 3.54e-53
Telomere C-strand synthesis initiation 13 1.69e-01 -2.20e-01 3.01e-01
IGF1R signaling cascade 38 1.87e-02 2.20e-01 5.70e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 3.67e-02 -2.20e-01 9.73e-02
IRS-related events triggered by IGF1R 37 2.05e-02 2.20e-01 6.06e-02
Signaling by KIT in disease 20 8.84e-02 2.20e-01 1.88e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 8.84e-02 2.20e-01 1.88e-01
Golgi Associated Vesicle Biogenesis 55 4.78e-03 -2.20e-01 1.83e-02
Apoptosis 158 1.85e-06 -2.20e-01 1.52e-05
RAS signaling downstream of NF1 loss-of-function variants 7 3.15e-01 2.19e-01 4.71e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 1.71e-01 -2.19e-01 3.04e-01
Negative regulation of FGFR1 signaling 25 5.80e-02 -2.19e-01 1.37e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 8.23e-02 -2.19e-01 1.79e-01
Glutamate and glutamine metabolism 12 1.90e-01 -2.19e-01 3.30e-01
Biosynthesis of EPA-derived SPMs 6 3.54e-01 2.19e-01 5.13e-01
Prostacyclin signalling through prostacyclin receptor 16 1.31e-01 -2.18e-01 2.54e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.43e-03 -2.17e-01 6.45e-03
RHOU GTPase cycle 40 1.76e-02 2.17e-01 5.40e-02
Signaling by FGFR3 in disease 14 1.60e-01 2.17e-01 2.91e-01
Synthesis of PIPs at the Golgi membrane 16 1.34e-01 2.16e-01 2.57e-01
Constitutive Signaling by EGFRvIII 14 1.61e-01 2.16e-01 2.93e-01
Signaling by EGFRvIII in Cancer 14 1.61e-01 2.16e-01 2.93e-01
Downstream signaling of activated FGFR3 17 1.23e-01 2.16e-01 2.43e-01
Protein-protein interactions at synapses 61 3.57e-03 2.16e-01 1.43e-02
TRAF6 mediated IRF7 activation 15 1.51e-01 2.14e-01 2.81e-01
Activation of PUMA and translocation to mitochondria 9 2.66e-01 2.14e-01 4.20e-01
Metabolism of steroid hormones 22 8.22e-02 -2.14e-01 1.79e-01
FLT3 signaling through SRC family kinases 6 3.65e-01 2.14e-01 5.22e-01
Purine salvage 12 2.00e-01 -2.14e-01 3.40e-01
SARS-CoV-2 Infection 267 1.87e-09 -2.14e-01 2.51e-08
RHOT2 GTPase cycle 7 3.28e-01 -2.13e-01 4.85e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 1.23e-02 -2.13e-01 4.08e-02
Negative regulation of FGFR4 signaling 22 8.41e-02 -2.13e-01 1.81e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 8.79e-06 -2.12e-01 6.56e-05
Hedgehog ‘on’ state 65 3.13e-03 -2.12e-01 1.28e-02
FGFRL1 modulation of FGFR1 signaling 7 3.32e-01 2.12e-01 4.89e-01
Pyroptosis 25 6.74e-02 -2.11e-01 1.53e-01
Cellular response to chemical stress 179 1.10e-06 -2.11e-01 9.32e-06
Signal attenuation 9 2.74e-01 -2.10e-01 4.29e-01
Recycling pathway of L1 40 2.14e-02 -2.10e-01 6.29e-02
TP53 Regulates Transcription of DNA Repair Genes 61 4.53e-03 -2.10e-01 1.75e-02
Platelet sensitization by LDL 16 1.46e-01 2.10e-01 2.74e-01
Meiotic synapsis 43 1.73e-02 -2.10e-01 5.33e-02
Disorders of transmembrane transporters 137 2.24e-05 -2.10e-01 1.50e-04
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 5.76e-04 -2.09e-01 2.90e-03
Amplification of signal from the kinetochores 91 5.76e-04 -2.09e-01 2.90e-03
Other semaphorin interactions 16 1.49e-01 2.09e-01 2.78e-01
MET activates RAS signaling 10 2.55e-01 2.08e-01 4.06e-01
CLEC7A/inflammasome pathway 6 3.78e-01 2.08e-01 5.36e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 1.11e-02 -2.07e-01 3.75e-02
RUNX3 regulates WNT signaling 8 3.10e-01 2.07e-01 4.67e-01
Activation of GABAB receptors 31 4.60e-02 2.07e-01 1.15e-01
GABA B receptor activation 31 4.60e-02 2.07e-01 1.15e-01
SARS-CoV Infections 433 1.46e-13 -2.07e-01 3.76e-12
Interleukin-23 signaling 7 3.43e-01 2.07e-01 5.02e-01
Regulation of TP53 Activity through Association with Co-factors 13 1.98e-01 2.06e-01 3.39e-01
Cell Cycle 611 3.15e-18 -2.06e-01 1.13e-16
Activation of RAC1 11 2.39e-01 2.05e-01 3.90e-01
SUMO is proteolytically processed 6 3.84e-01 -2.05e-01 5.44e-01
Repression of WNT target genes 14 1.85e-01 2.04e-01 3.23e-01
Nonhomologous End-Joining (NHEJ) 40 2.55e-02 -2.04e-01 7.27e-02
Iron uptake and transport 52 1.10e-02 -2.04e-01 3.71e-02
Biotin transport and metabolism 11 2.42e-01 -2.04e-01 3.93e-01
Trafficking of GluR2-containing AMPA receptors 11 2.43e-01 -2.03e-01 3.93e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 5.79e-02 2.03e-01 1.37e-01
Translation of Structural Proteins 9683701 29 5.83e-02 -2.03e-01 1.38e-01
Phase 2 - plateau phase 11 2.44e-01 2.03e-01 3.95e-01
Cell Cycle, Mitotic 488 1.77e-14 -2.03e-01 5.42e-13
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 2.53e-02 -2.02e-01 7.25e-02
Signaling by RAS mutants 41 2.53e-02 -2.02e-01 7.25e-02
Signaling by moderate kinase activity BRAF mutants 41 2.53e-02 -2.02e-01 7.25e-02
Signaling downstream of RAS mutants 41 2.53e-02 -2.02e-01 7.25e-02
NOTCH4 Intracellular Domain Regulates Transcription 19 1.28e-01 2.02e-01 2.49e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 3.55e-01 2.02e-01 5.14e-01
Axon guidance 459 1.28e-13 -2.02e-01 3.40e-12
Regulation of gene expression by Hypoxia-inducible Factor 8 3.23e-01 2.02e-01 4.79e-01
Fanconi Anemia Pathway 36 3.72e-02 -2.01e-01 9.85e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 1.79e-01 -2.00e-01 3.15e-01
Pyrimidine catabolism 9 2.98e-01 -2.00e-01 4.54e-01
Anchoring fibril formation 10 2.75e-01 1.99e-01 4.30e-01
Activated NTRK3 signals through RAS 7 3.61e-01 1.99e-01 5.19e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 3.63e-01 -1.98e-01 5.21e-01
Signaling by FLT3 ITD and TKD mutants 15 1.85e-01 1.98e-01 3.21e-01
Diseases of DNA repair 51 1.45e-02 -1.98e-01 4.60e-02
APC truncation mutants have impaired AXIN binding 14 2.00e-01 1.98e-01 3.40e-01
AXIN missense mutants destabilize the destruction complex 14 2.00e-01 1.98e-01 3.40e-01
Signaling by AMER1 mutants 14 2.00e-01 1.98e-01 3.40e-01
Signaling by APC mutants 14 2.00e-01 1.98e-01 3.40e-01
Signaling by AXIN mutants 14 2.00e-01 1.98e-01 3.40e-01
Truncations of AMER1 destabilize the destruction complex 14 2.00e-01 1.98e-01 3.40e-01
Asparagine N-linked glycosylation 286 8.54e-09 -1.98e-01 1.01e-07
CREB phosphorylation 7 3.65e-01 1.98e-01 5.22e-01
Signaling by ERBB2 ECD mutants 15 1.86e-01 1.97e-01 3.23e-01
Late SARS-CoV-2 Infection Events 64 6.34e-03 -1.97e-01 2.33e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 3.38e-03 -1.97e-01 1.37e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 2.81e-01 -1.97e-01 4.36e-01
Defective EXT2 causes exostoses 2 10 2.81e-01 -1.97e-01 4.36e-01
ALK mutants bind TKIs 11 2.58e-01 1.97e-01 4.10e-01
Signaling by ERBB2 in Cancer 21 1.19e-01 1.97e-01 2.36e-01
Metabolism of Angiotensinogen to Angiotensins 12 2.40e-01 1.96e-01 3.91e-01
Biosynthesis of maresin-like SPMs 5 4.49e-01 1.96e-01 5.98e-01
Ethanol oxidation 8 3.38e-01 -1.96e-01 4.96e-01
Platelet activation, signaling and aggregation 223 4.90e-07 -1.95e-01 4.38e-06
Role of ABL in ROBO-SLIT signaling 6 4.07e-01 1.95e-01 5.62e-01
mRNA Editing 8 3.39e-01 1.95e-01 4.96e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 7.91e-02 -1.95e-01 1.73e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 9.18e-02 -1.95e-01 1.93e-01
Activation of HOX genes during differentiation 70 4.86e-03 -1.95e-01 1.85e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 4.86e-03 -1.95e-01 1.85e-02
Signaling by cytosolic FGFR1 fusion mutants 18 1.53e-01 1.95e-01 2.83e-01
RHO GTPases Activate Formins 128 1.43e-04 -1.95e-01 8.25e-04
Response of Mtb to phagocytosis 22 1.14e-01 -1.95e-01 2.30e-01
Glycogen storage diseases 13 2.25e-01 -1.94e-01 3.71e-01
NCAM signaling for neurite out-growth 48 2.01e-02 1.94e-01 5.98e-02
Activation of C3 and C5 7 3.75e-01 -1.94e-01 5.34e-01
RHOV GTPase cycle 36 4.46e-02 1.93e-01 1.13e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.68e-01 1.93e-01 4.22e-01
Acetylcholine regulates insulin secretion 9 3.16e-01 1.93e-01 4.72e-01
Diseases associated with glycosaminoglycan metabolism 25 9.50e-02 -1.93e-01 1.98e-01
PLC beta mediated events 40 3.49e-02 1.93e-01 9.34e-02
Glycine degradation 7 3.77e-01 -1.93e-01 5.36e-01
G-protein mediated events 44 2.72e-02 1.92e-01 7.69e-02
N-glycan antennae elongation in the medial/trans-Golgi 21 1.28e-01 -1.92e-01 2.49e-01
Keratan sulfate degradation 9 3.20e-01 -1.91e-01 4.76e-01
Golgi-to-ER retrograde transport 123 2.59e-04 -1.91e-01 1.43e-03
Collagen chain trimerization 29 7.58e-02 1.90e-01 1.68e-01
Regulated proteolysis of p75NTR 11 2.74e-01 -1.90e-01 4.29e-01
Resolution of Sister Chromatid Cohesion 116 3.96e-04 -1.90e-01 2.12e-03
DAG and IP3 signaling 34 5.48e-02 1.90e-01 1.32e-01
Drug ADME 59 1.15e-02 -1.90e-01 3.84e-02
Mitochondrial biogenesis 91 1.70e-03 -1.90e-01 7.53e-03
E2F mediated regulation of DNA replication 22 1.23e-01 -1.90e-01 2.42e-01
Interleukin-4 and Interleukin-13 signaling 93 1.55e-03 1.90e-01 6.98e-03
Viral Messenger RNA Synthesis 44 2.94e-02 -1.90e-01 8.16e-02
Interleukin-1 signaling 99 1.11e-03 -1.90e-01 5.27e-03
Inhibition of Signaling by Overexpressed EGFR 6 4.22e-01 1.89e-01 5.74e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 4.22e-01 1.89e-01 5.74e-01
Nervous system development 478 1.27e-12 -1.89e-01 2.78e-11
SUMOylation of DNA methylation proteins 16 1.91e-01 -1.89e-01 3.30e-01
Erythrocytes take up carbon dioxide and release oxygen 11 2.78e-01 1.89e-01 4.34e-01
O2/CO2 exchange in erythrocytes 11 2.78e-01 1.89e-01 4.34e-01
CDC6 association with the ORC:origin complex 8 3.55e-01 -1.89e-01 5.14e-01
Cell-extracellular matrix interactions 16 1.91e-01 -1.89e-01 3.31e-01
TRIF-mediated programmed cell death 9 3.28e-01 1.88e-01 4.84e-01
PI-3K cascade:FGFR1 13 2.40e-01 1.88e-01 3.91e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
Signaling by CTNNB1 phospho-site mutants 15 2.07e-01 1.88e-01 3.49e-01
Signaling by GSK3beta mutants 15 2.07e-01 1.88e-01 3.49e-01
PKA-mediated phosphorylation of CREB 17 1.81e-01 1.87e-01 3.18e-01
Signaling by activated point mutants of FGFR1 5 4.68e-01 -1.87e-01 6.15e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 3.91e-01 1.87e-01 5.49e-01
Transcriptional regulation by RUNX3 81 3.60e-03 -1.87e-01 1.43e-02
Homologous DNA Pairing and Strand Exchange 43 3.39e-02 -1.87e-01 9.11e-02
PECAM1 interactions 12 2.63e-01 1.86e-01 4.17e-01
PKA activation 15 2.12e-01 1.86e-01 3.54e-01
Signaling by RAF1 mutants 37 5.00e-02 -1.86e-01 1.22e-01
Assembly of active LPL and LIPC lipase complexes 10 3.08e-01 -1.86e-01 4.65e-01
Mitotic Prophase 96 1.62e-03 -1.86e-01 7.25e-03
Constitutive Signaling by Aberrant PI3K in Cancer 59 1.34e-02 1.86e-01 4.35e-02
Signaling by TGFBR3 39 4.44e-02 1.86e-01 1.13e-01
Nuclear events stimulated by ALK signaling in cancer 33 6.45e-02 1.86e-01 1.47e-01
CaM pathway 28 8.94e-02 1.85e-01 1.90e-01
Calmodulin induced events 28 8.94e-02 1.85e-01 1.90e-01
Other interleukin signaling 19 1.63e-01 1.85e-01 2.94e-01
Biosynthesis of maresins 7 3.99e-01 1.84e-01 5.56e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 2.50e-01 -1.84e-01 4.02e-01
PI3K Cascade 31 7.67e-02 1.84e-01 1.69e-01
Ub-specific processing proteases 153 8.78e-05 -1.84e-01 5.20e-04
Receptor-type tyrosine-protein phosphatases 12 2.72e-01 1.83e-01 4.26e-01
Regulation of pyruvate metabolism 32 7.32e-02 -1.83e-01 1.63e-01
Regulation of TP53 Activity through Phosphorylation 88 3.17e-03 -1.82e-01 1.29e-02
Programmed Cell Death 187 1.81e-05 -1.82e-01 1.26e-04
Early SARS-CoV-2 Infection Events 31 8.00e-02 -1.82e-01 1.75e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.41e-01 -1.81e-01 2.67e-01
Hyaluronan metabolism 16 2.09e-01 -1.81e-01 3.50e-01
Ca-dependent events 30 8.61e-02 1.81e-01 1.84e-01
EML4 and NUDC in mitotic spindle formation 107 1.23e-03 -1.81e-01 5.71e-03
PKA activation in glucagon signalling 14 2.44e-01 1.80e-01 3.94e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.06e-01 -1.80e-01 2.17e-01
CLEC7A (Dectin-1) signaling 86 4.09e-03 -1.79e-01 1.60e-02
XBP1(S) activates chaperone genes 44 4.06e-02 -1.78e-01 1.06e-01
Negative regulation of FGFR2 signaling 24 1.31e-01 -1.78e-01 2.54e-01
Glycogen metabolism 21 1.59e-01 -1.78e-01 2.89e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.58e-03 -1.78e-01 1.43e-02
IRS-mediated signalling 35 6.98e-02 1.77e-01 1.57e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 4.93e-01 1.77e-01 6.37e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.26e-01 -1.77e-01 2.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.26e-01 -1.77e-01 2.47e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.26e-01 -1.77e-01 2.47e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.26e-01 -1.77e-01 2.47e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 4.54e-01 1.77e-01 6.01e-01
ERBB2 Activates PTK6 Signaling 8 3.88e-01 1.76e-01 5.47e-01
FLT3 signaling in disease 27 1.13e-01 1.76e-01 2.28e-01
Metalloprotease DUBs 20 1.72e-01 -1.76e-01 3.06e-01
WNT ligand biogenesis and trafficking 19 1.84e-01 1.76e-01 3.21e-01
Gastrulation 76 7.99e-03 -1.76e-01 2.85e-02
Leishmania infection 211 1.15e-05 -1.75e-01 8.39e-05
Parasitic Infection Pathways 211 1.15e-05 -1.75e-01 8.39e-05
RHO GTPases Activate WASPs and WAVEs 35 7.29e-02 -1.75e-01 1.62e-01
Sodium-coupled phosphate cotransporters 5 4.98e-01 1.75e-01 6.41e-01
Digestion and absorption 7 4.24e-01 -1.75e-01 5.76e-01
Plasma lipoprotein clearance 33 8.25e-02 -1.75e-01 1.79e-01
Gene Silencing by RNA 87 5.04e-03 -1.74e-01 1.91e-02
Estrogen biosynthesis 5 5.02e-01 1.73e-01 6.46e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 5.54e-02 -1.73e-01 1.33e-01
Diseases of DNA Double-Strand Break Repair 41 5.54e-02 -1.73e-01 1.33e-01
COPI-mediated anterograde transport 92 4.33e-03 -1.72e-01 1.68e-02
Cytosolic sulfonation of small molecules 18 2.08e-01 -1.71e-01 3.49e-01
Hedgehog ‘off’ state 91 4.72e-03 -1.71e-01 1.81e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 1.97e-02 -1.71e-01 5.92e-02
Sperm Motility And Taxes 6 4.68e-01 -1.71e-01 6.15e-01
Uptake and function of diphtheria toxin 6 4.69e-01 -1.71e-01 6.15e-01
Ion transport by P-type ATPases 43 5.26e-02 1.71e-01 1.27e-01
RHO GTPase Effectors 258 2.37e-06 -1.71e-01 1.92e-05
Activation of the phototransduction cascade 8 4.05e-01 1.70e-01 5.61e-01
Transcriptional Regulation by E2F6 34 8.61e-02 -1.70e-01 1.84e-01
Metabolic disorders of biological oxidation enzymes 26 1.36e-01 -1.69e-01 2.59e-01
Signaling by Leptin 10 3.56e-01 1.69e-01 5.14e-01
ER Quality Control Compartment (ERQC) 21 1.81e-01 -1.69e-01 3.18e-01
ERKs are inactivated 13 2.94e-01 -1.68e-01 4.50e-01
Signaling by PDGFRA extracellular domain mutants 12 3.13e-01 1.68e-01 4.70e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.13e-01 1.68e-01 4.70e-01
NGF-stimulated transcription 32 1.02e-01 1.67e-01 2.10e-01
Potential therapeutics for SARS 149 4.30e-04 -1.67e-01 2.27e-03
Serotonin Neurotransmitter Release Cycle 15 2.63e-01 1.67e-01 4.16e-01
Acyl chain remodeling of CL 5 5.18e-01 1.67e-01 6.57e-01
Processing of Intronless Pre-mRNAs 20 1.96e-01 -1.67e-01 3.37e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 2.08e-01 1.67e-01 3.49e-01
P2Y receptors 10 3.61e-01 1.67e-01 5.19e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.34e-01 -1.67e-01 2.57e-01
Signaling by FGFR2 61 2.44e-02 -1.67e-01 7.08e-02
HATs acetylate histones 92 5.84e-03 -1.66e-01 2.17e-02
Activation of BH3-only proteins 30 1.15e-01 -1.66e-01 2.32e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 6.96e-02 -1.66e-01 1.57e-01
O-linked glycosylation 85 8.39e-03 1.65e-01 2.96e-02
Cell junction organization 82 9.63e-03 1.65e-01 3.34e-02
Reversible hydration of carbon dioxide 8 4.18e-01 1.65e-01 5.72e-01
Histidine catabolism 7 4.50e-01 1.65e-01 5.99e-01
Establishment of Sister Chromatid Cohesion 11 3.44e-01 1.65e-01 5.02e-01
VxPx cargo-targeting to cilium 19 2.13e-01 1.65e-01 3.56e-01
Signaling by ERBB2 TMD/JMD mutants 17 2.39e-01 1.65e-01 3.91e-01
PTEN Regulation 127 1.37e-03 -1.64e-01 6.23e-03
Impaired BRCA2 binding to PALB2 24 1.63e-01 -1.64e-01 2.94e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 8.81e-02 -1.64e-01 1.88e-01
Synthesis of PC 23 1.73e-01 -1.64e-01 3.07e-01
Netrin mediated repulsion signals 5 5.25e-01 1.64e-01 6.61e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 3.95e-01 -1.64e-01 5.53e-01
RHOBTB2 GTPase cycle 23 1.74e-01 -1.64e-01 3.08e-01
RHOT1 GTPase cycle 5 5.26e-01 -1.64e-01 6.61e-01
Toxicity of botulinum toxin type D (botD) 5 5.26e-01 1.64e-01 6.61e-01
Toxicity of botulinum toxin type F (botF) 5 5.26e-01 1.64e-01 6.61e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 4.89e-01 1.63e-01 6.34e-01
Synthesis of substrates in N-glycan biosythesis 59 3.05e-02 -1.63e-01 8.41e-02
Glycerophospholipid catabolism 6 4.90e-01 1.63e-01 6.34e-01
Na+/Cl- dependent neurotransmitter transporters 8 4.26e-01 1.63e-01 5.79e-01
Suppression of apoptosis 7 4.56e-01 -1.63e-01 6.03e-01
Potassium Channels 64 2.47e-02 1.62e-01 7.15e-02
Reproduction 85 9.81e-03 -1.62e-01 3.38e-02
Synthesis, secretion, and deacylation of Ghrelin 11 3.52e-01 -1.62e-01 5.11e-01
Erythropoietin activates RAS 13 3.12e-01 1.62e-01 4.69e-01
IRE1alpha activates chaperones 46 5.76e-02 -1.62e-01 1.37e-01
Fatty acid metabolism 155 5.24e-04 -1.61e-01 2.70e-03
Transport and synthesis of PAPS 6 4.94e-01 -1.61e-01 6.37e-01
SUMOylation of RNA binding proteins 47 5.61e-02 -1.61e-01 1.34e-01
HDACs deacetylate histones 45 6.17e-02 -1.61e-01 1.42e-01
Regulation of HSF1-mediated heat shock response 79 1.34e-02 -1.61e-01 4.35e-02
Disease 1633 2.38e-27 -1.61e-01 1.15e-25
Caspase activation via extrinsic apoptotic signalling pathway 25 1.67e-01 1.60e-01 2.99e-01
Defensins 8 4.35e-01 -1.60e-01 5.85e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.59e-01 -1.59e-01 2.90e-01
Regulation of KIT signaling 15 2.86e-01 1.59e-01 4.41e-01
Phenylalanine metabolism 5 5.39e-01 -1.59e-01 6.71e-01
Vitamin D (calciferol) metabolism 11 3.63e-01 -1.59e-01 5.20e-01
Downregulation of TGF-beta receptor signaling 26 1.62e-01 -1.58e-01 2.93e-01
Collagen degradation 44 7.00e-02 1.58e-01 1.57e-01
G0 and Early G1 27 1.58e-01 -1.57e-01 2.87e-01
IRAK2 mediated activation of TAK1 complex 10 3.90e-01 -1.57e-01 5.48e-01
Triglyceride metabolism 26 1.66e-01 1.57e-01 2.98e-01
The phototransduction cascade 26 1.68e-01 -1.56e-01 3.00e-01
Fibronectin matrix formation 6 5.09e-01 -1.56e-01 6.51e-01
Tryptophan catabolism 12 3.50e-01 -1.56e-01 5.09e-01
Cardiac conduction 89 1.11e-02 1.56e-01 3.74e-02
Cargo recognition for clathrin-mediated endocytosis 89 1.17e-02 -1.55e-01 3.91e-02
Ca2+ pathway 58 4.19e-02 1.54e-01 1.08e-01
RHO GTPases activate IQGAPs 25 1.81e-01 -1.54e-01 3.18e-01
Defective LFNG causes SCDO3 5 5.50e-01 1.54e-01 6.81e-01
Diseases of mitotic cell cycle 38 1.01e-01 -1.54e-01 2.08e-01
Regulation of TP53 Degradation 35 1.15e-01 -1.54e-01 2.32e-01
Dopamine Neurotransmitter Release Cycle 20 2.34e-01 1.54e-01 3.83e-01
Hemostasis 562 4.49e-10 -1.54e-01 6.42e-09
Sema4D in semaphorin signaling 22 2.12e-01 -1.54e-01 3.54e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 3.38e-01 1.53e-01 4.96e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 2.13e-01 1.53e-01 3.55e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.12e-01 -1.53e-01 2.27e-01
Sphingolipid metabolism 91 1.17e-02 -1.53e-01 3.90e-02
AMPK inhibits chREBP transcriptional activation activity 6 5.17e-01 -1.53e-01 6.57e-01
PKMTs methylate histone lysines 44 8.03e-02 1.52e-01 1.76e-01
Recruitment of NuMA to mitotic centrosomes 88 1.43e-02 -1.51e-01 4.56e-02
Vesicle-mediated transport 669 2.85e-11 -1.51e-01 4.95e-10
SHC1 events in EGFR signaling 12 3.69e-01 1.50e-01 5.27e-01
Integrin signaling 22 2.25e-01 -1.49e-01 3.71e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.32e-01 -1.49e-01 2.54e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 2.07e-01 1.49e-01 3.49e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 2.07e-01 1.49e-01 3.49e-01
ISG15 antiviral mechanism 72 2.93e-02 -1.49e-01 8.16e-02
G beta:gamma signalling through BTK 15 3.21e-01 -1.48e-01 4.77e-01
Interferon alpha/beta signaling 64 4.07e-02 -1.48e-01 1.06e-01
Cell-Cell communication 114 6.39e-03 1.48e-01 2.35e-02
Biological oxidations 146 2.05e-03 -1.48e-01 8.85e-03
Circadian Clock 67 3.65e-02 1.48e-01 9.69e-02
Resolution of D-Loop Structures 35 1.31e-01 -1.48e-01 2.54e-01
Free fatty acids regulate insulin secretion 10 4.19e-01 1.48e-01 5.72e-01
RHO GTPases activate CIT 18 2.79e-01 -1.48e-01 4.34e-01
Thromboxane signalling through TP receptor 20 2.53e-01 -1.48e-01 4.05e-01
Synthesis of PE 12 3.76e-01 -1.47e-01 5.35e-01
Crosslinking of collagen fibrils 15 3.24e-01 1.47e-01 4.79e-01
Cyclin D associated events in G1 47 8.12e-02 -1.47e-01 1.77e-01
G1 Phase 47 8.12e-02 -1.47e-01 1.77e-01
Glutamate Neurotransmitter Release Cycle 20 2.56e-01 1.47e-01 4.07e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 4.01e-01 1.46e-01 5.59e-01
RNA polymerase II transcribes snRNA genes 71 3.33e-02 -1.46e-01 9.01e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 5.72e-01 -1.46e-01 7.00e-01
Regulation of TP53 Expression and Degradation 36 1.31e-01 -1.46e-01 2.54e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 5.05e-01 -1.45e-01 6.48e-01
Antiviral mechanism by IFN-stimulated genes 140 2.99e-03 -1.45e-01 1.23e-02
DAP12 interactions 39 1.18e-01 1.45e-01 2.35e-01
Formation of annular gap junctions 10 4.29e-01 -1.45e-01 5.80e-01
Mitotic Prometaphase 193 5.42e-04 -1.44e-01 2.76e-03
Transport to the Golgi and subsequent modification 171 1.15e-03 -1.44e-01 5.42e-03
Depolymerization of the Nuclear Lamina 15 3.37e-01 -1.43e-01 4.95e-01
GRB2 events in EGFR signaling 11 4.13e-01 1.43e-01 5.66e-01
NRAGE signals death through JNK 52 7.52e-02 1.43e-01 1.66e-01
Beta-catenin independent WNT signaling 126 5.73e-03 -1.43e-01 2.14e-02
Antigen processing: Ubiquitination & Proteasome degradation 275 4.90e-05 -1.42e-01 3.10e-04
Uptake of dietary cobalamins into enterocytes 6 5.47e-01 1.42e-01 6.78e-01
TGFBR3 regulates TGF-beta signaling 8 4.87e-01 1.42e-01 6.32e-01
ADP signalling through P2Y purinoceptor 12 18 2.98e-01 -1.42e-01 4.54e-01
Plasma lipoprotein remodeling 18 2.98e-01 -1.42e-01 4.54e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 7.37e-04 -1.42e-01 3.60e-03
Signaling by PDGFR in disease 19 2.86e-01 1.42e-01 4.41e-01
Defects in vitamin and cofactor metabolism 21 2.63e-01 -1.41e-01 4.16e-01
Metabolism of vitamins and cofactors 166 1.70e-03 -1.41e-01 7.53e-03
Signaling by BRAF and RAF1 fusions 60 5.86e-02 -1.41e-01 1.38e-01
RAC1 GTPase cycle 173 1.38e-03 1.41e-01 6.26e-03
Post-translational modification: synthesis of GPI-anchored proteins 59 6.12e-02 -1.41e-01 1.42e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.43e-01 -1.41e-01 3.93e-01
TCR signaling 110 1.08e-02 -1.41e-01 3.67e-02
Assembly and cell surface presentation of NMDA receptors 34 1.56e-01 1.41e-01 2.85e-01
Signaling by NODAL 15 3.48e-01 -1.40e-01 5.06e-01
Cellular response to heat stress 94 1.95e-02 -1.39e-01 5.87e-02
Deadenylation of mRNA 22 2.58e-01 -1.39e-01 4.10e-01
Cytosolic sensors of pathogen-associated DNA 63 5.77e-02 -1.38e-01 1.37e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.18e-01 -1.38e-01 2.35e-01
Regulation of insulin secretion 63 5.98e-02 1.37e-01 1.39e-01
AKT phosphorylates targets in the nucleus 9 4.77e-01 1.37e-01 6.23e-01
Neurotoxicity of clostridium toxins 9 4.77e-01 1.37e-01 6.23e-01
EGFR Transactivation by Gastrin 7 5.31e-01 1.37e-01 6.64e-01
GRB2 events in ERBB2 signaling 11 4.32e-01 1.37e-01 5.83e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 4.32e-01 -1.37e-01 5.83e-01
MTOR signalling 39 1.40e-01 -1.36e-01 2.67e-01
Signaling by FGFR1 in disease 32 1.86e-01 1.35e-01 3.24e-01
PKR-mediated signaling 67 5.65e-02 -1.35e-01 1.35e-01
Activation of AMPK downstream of NMDARs 20 2.97e-01 -1.35e-01 4.54e-01
Glycosphingolipid transport 7 5.37e-01 -1.35e-01 6.71e-01
HDL remodeling 6 5.70e-01 -1.34e-01 6.98e-01
Activation of gene expression by SREBF (SREBP) 42 1.35e-01 1.33e-01 2.59e-01
Activated NTRK2 signals through FRS2 and FRS3 8 5.14e-01 1.33e-01 6.55e-01
Transcriptional Regulation by TP53 346 2.15e-05 -1.33e-01 1.44e-04
SUMOylation of DNA replication proteins 46 1.20e-01 -1.33e-01 2.38e-01
Signaling by NOTCH 175 2.48e-03 -1.33e-01 1.04e-02
Mucopolysaccharidoses 11 4.48e-01 -1.32e-01 5.98e-01
Defective B4GALT7 causes EDS, progeroid type 11 4.51e-01 -1.31e-01 5.99e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 6.13e-01 1.31e-01 7.33e-01
O-linked glycosylation of mucins 47 1.23e-01 1.30e-01 2.43e-01
STAT5 Activation 7 5.52e-01 1.30e-01 6.82e-01
Laminin interactions 26 2.52e-01 1.30e-01 4.03e-01
Class I MHC mediated antigen processing & presentation 344 3.52e-05 -1.30e-01 2.30e-04
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 5.52e-01 1.30e-01 6.82e-01
CD28 dependent Vav1 pathway 12 4.37e-01 1.30e-01 5.87e-01
Interactions of Rev with host cellular proteins 37 1.74e-01 -1.29e-01 3.08e-01
GPCR ligand binding 241 5.53e-04 1.29e-01 2.81e-03
ER to Golgi Anterograde Transport 145 7.44e-03 -1.29e-01 2.68e-02
Synthesis of IP3 and IP4 in the cytosol 22 2.98e-01 1.28e-01 4.54e-01
Striated Muscle Contraction 27 2.49e-01 1.28e-01 4.01e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.96e-01 -1.28e-01 3.37e-01
Phospholipase C-mediated cascade; FGFR2 8 5.31e-01 1.28e-01 6.64e-01
Transcriptional regulation of granulopoiesis 44 1.42e-01 -1.28e-01 2.68e-01
Sema4D induced cell migration and growth-cone collapse 19 3.35e-01 -1.28e-01 4.92e-01
AURKA Activation by TPX2 72 6.12e-02 -1.28e-01 1.42e-01
TRAF6 mediated NF-kB activation 23 2.90e-01 1.27e-01 4.46e-01
Plasma lipoprotein assembly 10 4.86e-01 1.27e-01 6.32e-01
Sphingolipid catabolism 11 4.67e-01 -1.27e-01 6.15e-01
CTLA4 inhibitory signaling 21 3.16e-01 1.27e-01 4.71e-01
Neuronal System 276 3.00e-04 1.26e-01 1.63e-03
MET activates RAP1 and RAC1 10 4.91e-01 1.26e-01 6.35e-01
Rev-mediated nuclear export of HIV RNA 35 1.98e-01 -1.26e-01 3.39e-01
Mitochondrial Uncoupling 6 5.94e-01 -1.26e-01 7.17e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.29e-02 -1.26e-01 1.10e-01
Tight junction interactions 17 3.70e-01 -1.25e-01 5.29e-01
Molybdenum cofactor biosynthesis 6 5.95e-01 -1.25e-01 7.17e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 5.39e-01 1.25e-01 6.71e-01
Oxidative Stress Induced Senescence 77 5.82e-02 -1.25e-01 1.37e-01
Eicosanoids 6 5.97e-01 1.25e-01 7.19e-01
SUMOylation of ubiquitinylation proteins 39 1.79e-01 -1.24e-01 3.15e-01
Apoptotic execution phase 46 1.46e-01 -1.24e-01 2.73e-01
Regulation of NF-kappa B signaling 18 3.65e-01 -1.23e-01 5.22e-01
SUMOylation of transcription factors 16 3.93e-01 -1.23e-01 5.52e-01
Regulation of TLR by endogenous ligand 15 4.11e-01 1.23e-01 5.64e-01
G-protein activation 19 3.56e-01 -1.22e-01 5.14e-01
Signal regulatory protein family interactions 13 4.46e-01 -1.22e-01 5.96e-01
Neurotransmitter release cycle 38 1.93e-01 1.22e-01 3.33e-01
CS/DS degradation 9 5.27e-01 -1.22e-01 6.61e-01
Clathrin-mediated endocytosis 128 1.72e-02 -1.22e-01 5.32e-02
Interleukin-12 signaling 44 1.62e-01 -1.22e-01 2.93e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.48e-01 -1.22e-01 5.98e-01
Diseases of metabolism 208 2.52e-03 -1.21e-01 1.06e-02
Prolactin receptor signaling 12 4.66e-01 -1.21e-01 6.14e-01
Maternal to zygotic transition (MZT) 72 7.51e-02 -1.21e-01 1.66e-01
Post-translational protein modification 1243 6.19e-13 -1.21e-01 1.44e-11
Signaling by FGFR2 in disease 33 2.28e-01 -1.21e-01 3.75e-01
Centrosome maturation 81 5.93e-02 -1.21e-01 1.39e-01
Recruitment of mitotic centrosome proteins and complexes 81 5.93e-02 -1.21e-01 1.39e-01
MET receptor recycling 9 5.29e-01 1.21e-01 6.63e-01
Regulation of IFNG signaling 14 4.34e-01 1.21e-01 5.85e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 3.75e-01 1.21e-01 5.34e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 2.05e-01 1.21e-01 3.47e-01
Regulation of FZD by ubiquitination 16 4.04e-01 1.20e-01 5.61e-01
HS-GAG biosynthesis 20 3.52e-01 -1.20e-01 5.11e-01
Degradation of the extracellular matrix 99 3.87e-02 1.20e-01 1.01e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 5.40e-02 1.20e-01 1.30e-01
Interleukin-12 family signaling 53 1.31e-01 -1.20e-01 2.54e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 4.22e-01 -1.20e-01 5.75e-01
Negative regulation of the PI3K/AKT network 93 4.67e-02 1.19e-01 1.16e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 5.85e-01 1.19e-01 7.11e-01
Loss of Nlp from mitotic centrosomes 69 8.67e-02 -1.19e-01 1.85e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 8.67e-02 -1.19e-01 1.85e-01
Downregulation of ERBB2 signaling 24 3.12e-01 -1.19e-01 4.69e-01
Regulation of TP53 Activity through Methylation 19 3.69e-01 -1.19e-01 5.27e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.83e-01 -1.19e-01 3.19e-01
Assembly of collagen fibrils and other multimeric structures 44 1.73e-01 1.19e-01 3.07e-01
Signaling by GPCR 442 1.90e-05 1.19e-01 1.30e-04
Adipogenesis 96 4.48e-02 1.19e-01 1.13e-01
Signal amplification 28 2.79e-01 -1.18e-01 4.34e-01
Cardiogenesis 16 4.13e-01 1.18e-01 5.66e-01
RUNX1 regulates expression of components of tight junctions 5 6.48e-01 1.18e-01 7.54e-01
G alpha (q) signalling events 139 1.67e-02 1.18e-01 5.19e-02
Regulation of signaling by NODAL 6 6.19e-01 1.17e-01 7.37e-01
RSK activation 7 5.94e-01 -1.16e-01 7.17e-01
Transcriptional regulation of white adipocyte differentiation 77 7.80e-02 1.16e-01 1.72e-01
Defective B3GAT3 causes JDSSDHD 11 5.05e-01 -1.16e-01 6.48e-01
Amino acid transport across the plasma membrane 26 3.07e-01 -1.16e-01 4.64e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 4.90e-01 -1.15e-01 6.34e-01
Cytochrome P450 - arranged by substrate type 38 2.21e-01 1.15e-01 3.66e-01
Signaling by PDGF 50 1.63e-01 1.14e-01 2.94e-01
Acetylcholine Neurotransmitter Release Cycle 11 5.13e-01 1.14e-01 6.55e-01
Metabolism of amine-derived hormones 10 5.33e-01 1.14e-01 6.66e-01
Endogenous sterols 18 4.05e-01 1.13e-01 5.61e-01
VEGFR2 mediated cell proliferation 18 4.05e-01 -1.13e-01 5.62e-01
Cellular Senescence 143 1.95e-02 -1.13e-01 5.87e-02
Transport of the SLBP Dependant Mature mRNA 36 2.40e-01 -1.13e-01 3.91e-01
Frs2-mediated activation 11 5.17e-01 -1.13e-01 6.57e-01
Surfactant metabolism 21 3.71e-01 -1.13e-01 5.30e-01
Keratan sulfate biosynthesis 20 3.84e-01 1.12e-01 5.44e-01
Signaling by Hedgehog 120 3.36e-02 -1.12e-01 9.08e-02
Transcriptional regulation by RUNX1 170 1.17e-02 -1.12e-01 3.90e-02
TGF-beta receptor signaling activates SMADs 45 1.96e-01 -1.12e-01 3.37e-01
Regulation of localization of FOXO transcription factors 11 5.22e-01 -1.11e-01 6.61e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 3.17e-01 -1.11e-01 4.72e-01
Deactivation of the beta-catenin transactivating complex 36 2.48e-01 1.11e-01 3.99e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 3.90e-01 1.11e-01 5.49e-01
RND2 GTPase cycle 37 2.43e-01 1.11e-01 3.94e-01
Signaling by NTRK2 (TRKB) 20 3.91e-01 1.11e-01 5.49e-01
FGFR1c ligand binding and activation 8 5.88e-01 -1.11e-01 7.13e-01
Cell recruitment (pro-inflammatory response) 25 3.39e-01 -1.11e-01 4.96e-01
Purinergic signaling in leishmaniasis infection 25 3.39e-01 -1.11e-01 4.96e-01
RHO GTPases Activate NADPH Oxidases 21 3.81e-01 1.10e-01 5.41e-01
Downregulation of ERBB2:ERBB3 signaling 12 5.08e-01 -1.10e-01 6.51e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 4.32e-01 1.10e-01 5.83e-01
SUMOylation of chromatin organization proteins 57 1.51e-01 -1.10e-01 2.81e-01
Effects of PIP2 hydrolysis 24 3.52e-01 1.10e-01 5.11e-01
Activated NTRK2 signals through RAS 6 6.42e-01 1.10e-01 7.49e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 9.99e-03 -1.09e-01 3.43e-02
Activation of G protein gated Potassium channels 20 3.98e-01 1.09e-01 5.56e-01
G protein gated Potassium channels 20 3.98e-01 1.09e-01 5.56e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 3.98e-01 1.09e-01 5.56e-01
Biosynthesis of E-series 18(S)-resolvins 5 6.73e-01 1.09e-01 7.72e-01
RET signaling 32 2.86e-01 1.09e-01 4.42e-01
IRF3-mediated induction of type I IFN 12 5.14e-01 -1.09e-01 6.55e-01
RAC2 GTPase cycle 86 8.24e-02 1.08e-01 1.79e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 3.14e-01 -1.08e-01 4.71e-01
Antimicrobial peptides 34 2.79e-01 -1.07e-01 4.34e-01
Attachment of GPI anchor to uPAR 7 6.23e-01 -1.07e-01 7.39e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 1.66e-01 -1.07e-01 2.98e-01
RUNX2 regulates genes involved in cell migration 6 6.50e-01 1.07e-01 7.55e-01
Interleukin-1 family signaling 127 3.78e-02 -1.07e-01 9.96e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 1.93e-01 1.06e-01 3.33e-01
Membrane Trafficking 577 1.29e-05 -1.06e-01 9.38e-05
TNFR1-induced NF-kappa-B signaling pathway 32 2.99e-01 1.06e-01 4.56e-01
Interactions of Vpr with host cellular proteins 37 2.67e-01 -1.05e-01 4.22e-01
Sensory processing of sound by inner hair cells of the cochlea 54 1.84e-01 1.04e-01 3.21e-01
Transmission across Chemical Synapses 188 1.36e-02 1.04e-01 4.39e-02
CD28 dependent PI3K/Akt signaling 22 4.00e-01 1.04e-01 5.58e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 2.70e-01 -1.03e-01 4.25e-01
Synthesis of PIPs at the late endosome membrane 11 5.53e-01 1.03e-01 6.82e-01
Phospholipase C-mediated cascade; FGFR4 6 6.62e-01 1.03e-01 7.64e-01
STAT5 activation downstream of FLT3 ITD mutants 9 5.92e-01 1.03e-01 7.17e-01
Organic cation transport 8 6.14e-01 1.03e-01 7.33e-01
Organic cation/anion/zwitterion transport 8 6.14e-01 1.03e-01 7.33e-01
GPCR downstream signalling 398 4.33e-04 1.03e-01 2.28e-03
Nuclear Events (kinase and transcription factor activation) 54 1.92e-01 1.03e-01 3.33e-01
Miscellaneous transport and binding events 20 4.28e-01 -1.02e-01 5.80e-01
Carnitine shuttle 12 5.40e-01 1.02e-01 6.72e-01
FGFR2b ligand binding and activation 6 6.66e-01 1.02e-01 7.65e-01
Dermatan sulfate biosynthesis 6 6.66e-01 -1.02e-01 7.65e-01
Acyl chain remodelling of PC 19 4.43e-01 1.02e-01 5.93e-01
Regulation of TP53 Activity through Acetylation 29 3.44e-01 1.01e-01 5.02e-01
HS-GAG degradation 19 4.46e-01 -1.01e-01 5.96e-01
activated TAK1 mediates p38 MAPK activation 23 4.02e-01 -1.01e-01 5.59e-01
Interferon Signaling 240 7.13e-03 -1.01e-01 2.59e-02
cGMP effects 12 5.46e-01 -1.01e-01 6.77e-01
PI3K/AKT Signaling in Cancer 85 1.09e-01 1.01e-01 2.22e-01
Apoptotic cleavage of cell adhesion proteins 8 6.23e-01 -1.00e-01 7.39e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 4.05e-01 -1.00e-01 5.62e-01
Metabolism of water-soluble vitamins and cofactors 115 6.36e-02 -1.00e-01 1.46e-01
EPH-Ephrin signaling 81 1.20e-01 -9.99e-02 2.38e-01
Organelle biogenesis and maintenance 277 4.24e-03 -9.98e-02 1.65e-02
A tetrasaccharide linker sequence is required for GAG synthesis 17 4.76e-01 -9.98e-02 6.23e-01
Sensory perception of taste 22 4.18e-01 9.98e-02 5.72e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.86e-01 9.95e-02 7.12e-01
PI5P Regulates TP53 Acetylation 8 6.26e-01 9.95e-02 7.41e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 4.17e-02 9.93e-02 1.08e-01
PI3K/AKT activation 8 6.27e-01 9.91e-02 7.41e-01
G alpha (s) signalling events 97 9.27e-02 9.88e-02 1.94e-01
Regulation of TP53 Activity 153 3.52e-02 -9.87e-02 9.39e-02
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 5.24e-01 9.85e-02 6.61e-01
OAS antiviral response 8 6.30e-01 -9.84e-02 7.42e-01
HDR through Single Strand Annealing (SSA) 37 3.02e-01 -9.80e-02 4.59e-01
Inwardly rectifying K+ channels 24 4.07e-01 9.78e-02 5.62e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 5.75e-01 -9.77e-02 7.01e-01
Organic anion transporters 7 6.55e-01 -9.75e-02 7.60e-01
Respiratory Syncytial Virus Infection Pathway 99 9.42e-02 -9.73e-02 1.97e-01
Beta-catenin phosphorylation cascade 17 4.88e-01 9.71e-02 6.33e-01
MAPK1 (ERK2) activation 9 6.14e-01 9.71e-02 7.33e-01
SUMOylation of SUMOylation proteins 35 3.21e-01 -9.69e-02 4.77e-01
LDL clearance 18 4.78e-01 -9.67e-02 6.24e-01
GPVI-mediated activation cascade 33 3.37e-01 9.65e-02 4.95e-01
Glycosphingolipid metabolism 46 2.58e-01 -9.64e-02 4.10e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.17e-01 9.63e-02 3.60e-01
Butyrophilin (BTN) family interactions 9 6.17e-01 9.62e-02 7.35e-01
Sensory Perception 197 1.99e-02 9.62e-02 5.96e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 7.10e-01 -9.59e-02 8.06e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 7.10e-01 -9.59e-02 8.06e-01
Activation of Matrix Metalloproteinases 22 4.36e-01 9.59e-02 5.87e-01
RUNX3 regulates CDKN1A transcription 7 6.62e-01 9.55e-02 7.64e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 3.83e-01 -9.53e-02 5.42e-01
Metabolism of carbohydrates 241 1.10e-02 -9.51e-02 3.71e-02
Ovarian tumor domain proteases 37 3.17e-01 9.50e-02 4.72e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 5.38e-01 -9.50e-02 6.71e-01
Impaired BRCA2 binding to RAD51 35 3.32e-01 -9.48e-02 4.89e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 5.71e-01 -9.45e-02 6.99e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 4.43e-01 9.45e-02 5.93e-01
DAP12 signaling 28 3.87e-01 9.44e-02 5.47e-01
Norepinephrine Neurotransmitter Release Cycle 14 5.42e-01 9.41e-02 6.74e-01
Signaling by SCF-KIT 40 3.05e-01 9.37e-02 4.62e-01
Formation of definitive endoderm 9 6.27e-01 9.36e-02 7.41e-01
Nuclear import of Rev protein 34 3.45e-01 -9.35e-02 5.03e-01
Transferrin endocytosis and recycling 26 4.10e-01 -9.33e-02 5.64e-01
Maturation of protein 3a 9683673 9 6.28e-01 9.33e-02 7.41e-01
Maturation of protein 3a 9694719 9 6.28e-01 9.33e-02 7.41e-01
Class A/1 (Rhodopsin-like receptors) 175 3.44e-02 9.27e-02 9.22e-02
EPHB-mediated forward signaling 40 3.10e-01 -9.27e-02 4.67e-01
Synthesis of very long-chain fatty acyl-CoAs 22 4.52e-01 -9.25e-02 6.00e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 4.06e-01 -9.24e-02 5.62e-01
Adaptive Immune System 768 1.37e-05 -9.22e-02 9.83e-05
Killing mechanisms 9 6.33e-01 -9.18e-02 7.43e-01
WNT5:FZD7-mediated leishmania damping 9 6.33e-01 -9.18e-02 7.43e-01
Heme biosynthesis 13 5.69e-01 -9.12e-02 6.98e-01
Listeria monocytogenes entry into host cells 17 5.17e-01 -9.07e-02 6.57e-01
Respiratory syncytial virus (RSV) attachment and entry 18 5.06e-01 9.05e-02 6.49e-01
Gap junction assembly 17 5.20e-01 -9.01e-02 6.59e-01
CDC42 GTPase cycle 141 6.50e-02 9.00e-02 1.48e-01
FRS-mediated FGFR2 signaling 15 5.48e-01 8.97e-02 6.78e-01
Transport of the SLBP independent Mature mRNA 35 3.59e-01 -8.96e-02 5.17e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 5.23e-01 8.95e-02 6.61e-01
Insulin receptor signalling cascade 40 3.28e-01 8.93e-02 4.85e-01
COPII-mediated vesicle transport 67 2.07e-01 -8.91e-02 3.49e-01
ROS and RNS production in phagocytes 30 4.00e-01 -8.87e-02 5.58e-01
Gain-of-function MRAS complexes activate RAF signaling 8 6.64e-01 8.86e-02 7.65e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 6.64e-01 8.86e-02 7.65e-01
Signaling by MRAS-complex mutants 8 6.64e-01 8.86e-02 7.65e-01
Negative regulation of MET activity 18 5.16e-01 8.85e-02 6.56e-01
Integration of energy metabolism 88 1.52e-01 8.84e-02 2.82e-01
Growth hormone receptor signaling 21 4.83e-01 8.84e-02 6.29e-01
Acyl chain remodelling of PE 20 4.94e-01 -8.83e-02 6.37e-01
Downstream signal transduction 27 4.28e-01 8.82e-02 5.80e-01
Transcriptional activation of mitochondrial biogenesis 52 2.71e-01 8.82e-02 4.26e-01
RND3 GTPase cycle 36 3.60e-01 8.81e-02 5.19e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 4.56e-01 8.80e-02 6.03e-01
Aspartate and asparagine metabolism 9 6.49e-01 8.77e-02 7.54e-01
Signaling by ALK fusions and activated point mutants 89 1.54e-01 8.74e-02 2.84e-01
Signaling by ALK in cancer 89 1.54e-01 8.74e-02 2.84e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 5.11e-01 -8.72e-02 6.53e-01
Nephron development 5 7.36e-01 8.71e-02 8.23e-01
Sensory processing of sound 58 2.52e-01 8.69e-02 4.03e-01
RAB geranylgeranylation 61 2.40e-01 -8.69e-02 3.91e-01
CD28 co-stimulation 33 3.88e-01 8.68e-02 5.47e-01
MET activates PTK2 signaling 23 4.72e-01 -8.67e-02 6.18e-01
Notch-HLH transcription pathway 28 4.27e-01 8.67e-02 5.80e-01
DARPP-32 events 22 4.83e-01 -8.64e-02 6.29e-01
FGFR1 mutant receptor activation 25 4.55e-01 8.62e-02 6.03e-01
Inositol phosphate metabolism 42 3.34e-01 8.62e-02 4.91e-01
Sema3A PAK dependent Axon repulsion 15 5.64e-01 8.61e-02 6.92e-01
Oncogenic MAPK signaling 76 1.98e-01 -8.54e-02 3.39e-01
Diseases associated with surfactant metabolism 6 7.17e-01 -8.53e-02 8.10e-01
Heparan sulfate/heparin (HS-GAG) metabolism 40 3.51e-01 -8.53e-02 5.10e-01
Innate Immune System 971 8.41e-06 -8.44e-02 6.32e-05
Glucagon signaling in metabolic regulation 26 4.56e-01 8.44e-02 6.03e-01
RUNX2 regulates osteoblast differentiation 21 5.05e-01 8.40e-02 6.48e-01
Eicosanoid ligand-binding receptors 13 6.03e-01 -8.33e-02 7.24e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 6.33e-01 -8.32e-02 7.43e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 7.03e-01 8.31e-02 7.99e-01
Zinc transporters 12 6.18e-01 -8.31e-02 7.36e-01
SUMOylation of intracellular receptors 26 4.66e-01 8.25e-02 6.14e-01
Sensing of DNA Double Strand Breaks 6 7.27e-01 8.21e-02 8.19e-01
Nuclear Envelope Breakdown 53 3.05e-01 -8.14e-02 4.62e-01
Formation of the Editosome 6 7.31e-01 8.11e-02 8.20e-01
mRNA Editing: C to U Conversion 6 7.31e-01 8.11e-02 8.20e-01
Signaling by EGFR in Cancer 23 5.03e-01 8.07e-02 6.47e-01
Synthesis of 5-eicosatetraenoic acids 7 7.13e-01 -8.04e-02 8.07e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 2.85e-01 -7.92e-02 4.40e-01
Developmental Biology 929 4.27e-05 -7.92e-02 2.74e-04
G alpha (12/13) signalling events 68 2.61e-01 7.88e-02 4.14e-01
Neutrophil degranulation 458 3.85e-03 -7.88e-02 1.52e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 6.23e-01 -7.87e-02 7.39e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 7.38e-01 7.87e-02 8.25e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 2.21e-01 7.86e-02 3.66e-01
Defects in cobalamin (B12) metabolism 13 6.24e-01 -7.86e-02 7.39e-01
FOXO-mediated transcription of cell cycle genes 15 6.00e-01 7.82e-02 7.22e-01
Regulation of TNFR1 signaling 47 3.57e-01 7.77e-02 5.15e-01
Vitamin B2 (riboflavin) metabolism 6 7.42e-01 -7.75e-02 8.27e-01
Nicotinamide salvaging 15 6.03e-01 -7.75e-02 7.24e-01
Netrin-1 signaling 35 4.28e-01 7.74e-02 5.80e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.52e-01 -7.68e-02 6.00e-01
Kidney development 17 5.86e-01 -7.63e-02 7.12e-01
NOD1/2 Signaling Pathway 36 4.29e-01 7.62e-02 5.80e-01
C-type lectin receptors (CLRs) 118 1.53e-01 -7.62e-02 2.83e-01
SLC15A4:TASL-dependent IRF5 activation 6 7.48e-01 -7.59e-02 8.31e-01
SUMOylation of DNA damage response and repair proteins 77 2.50e-01 -7.58e-02 4.02e-01
Stimuli-sensing channels 81 2.40e-01 7.55e-02 3.91e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 4.04e-01 -7.54e-02 5.61e-01
Synthesis of PG 8 7.12e-01 7.54e-02 8.06e-01
Fatty acyl-CoA biosynthesis 35 4.40e-01 -7.54e-02 5.91e-01
Neurofascin interactions 5 7.72e-01 7.47e-02 8.50e-01
Deubiquitination 225 5.41e-02 -7.45e-02 1.30e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.52e-01 7.45e-02 8.33e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.52e-01 7.45e-02 8.33e-01
Phospholipid metabolism 183 8.35e-02 7.42e-02 1.80e-01
FGFR2c ligand binding and activation 5 7.76e-01 7.36e-02 8.51e-01
Glucose metabolism 76 2.71e-01 -7.31e-02 4.25e-01
Toll Like Receptor 4 (TLR4) Cascade 138 1.38e-01 7.30e-02 2.63e-01
Acyl chain remodelling of PS 14 6.37e-01 7.28e-02 7.45e-01
Signaling by FGFR 73 2.84e-01 -7.25e-02 4.40e-01
FRS-mediated FGFR4 signaling 13 6.52e-01 7.23e-02 7.57e-01
SHC-mediated cascade:FGFR2 13 6.52e-01 7.22e-02 7.57e-01
PD-1 signaling 28 5.09e-01 7.21e-02 6.52e-01
Phosphorylation of CD3 and TCR zeta chains 27 5.18e-01 7.19e-02 6.57e-01
RHOF GTPase cycle 39 4.38e-01 7.18e-02 5.88e-01
Uptake and function of anthrax toxins 11 6.81e-01 7.16e-02 7.80e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.95e-01 -7.15e-02 7.94e-01
Bacterial Infection Pathways 66 3.15e-01 -7.15e-02 4.71e-01
Gap junction trafficking 28 5.14e-01 -7.13e-02 6.55e-01
Biosynthesis of DHA-derived SPMs 15 6.33e-01 7.12e-02 7.43e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.96e-01 -7.03e-02 7.18e-01
G beta:gamma signalling through PLC beta 17 6.17e-01 -7.01e-02 7.35e-01
Presynaptic function of Kainate receptors 17 6.17e-01 -7.01e-02 7.35e-01
Vitamin B5 (pantothenate) metabolism 20 5.88e-01 -6.99e-02 7.13e-01
Muscle contraction 145 1.48e-01 6.96e-02 2.76e-01
Glycolysis 68 3.22e-01 -6.95e-02 4.78e-01
Costimulation by the CD28 family 74 3.05e-01 6.90e-02 4.62e-01
Loss of Function of TGFBR1 in Cancer 7 7.52e-01 -6.89e-02 8.33e-01
Small interfering RNA (siRNA) biogenesis 9 7.21e-01 6.88e-02 8.12e-01
Aspirin ADME 16 6.36e-01 -6.84e-02 7.44e-01
Carboxyterminal post-translational modifications of tubulin 34 4.90e-01 -6.84e-02 6.34e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 4.97e-01 6.84e-02 6.40e-01
Nuclear signaling by ERBB4 24 5.63e-01 -6.83e-02 6.92e-01
Ion homeostasis 42 4.44e-01 6.82e-02 5.94e-01
Signaling by Non-Receptor Tyrosine Kinases 47 4.20e-01 -6.81e-02 5.72e-01
Signaling by PTK6 47 4.20e-01 -6.81e-02 5.72e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.59e-01 -6.80e-02 7.62e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.59e-01 -6.80e-02 7.62e-01
SARS-CoV-1 activates/modulates innate immune responses 40 4.58e-01 -6.79e-02 6.04e-01
Pre-NOTCH Processing in Golgi 18 6.20e-01 6.75e-02 7.37e-01
Signaling by Hippo 18 6.20e-01 6.75e-02 7.37e-01
Creatine metabolism 6 7.75e-01 6.73e-02 8.51e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 5.63e-01 -6.69e-02 6.92e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 4.14e-01 -6.68e-02 5.67e-01
Ion channel transport 141 1.71e-01 6.68e-02 3.04e-01
Fertilization 12 6.90e-01 -6.65e-02 7.89e-01
Gamma-carboxylation of protein precursors 6 7.80e-01 6.60e-02 8.55e-01
FLT3 Signaling 38 4.83e-01 6.58e-02 6.29e-01
FGFR3 ligand binding and activation 5 8.00e-01 6.56e-02 8.67e-01
FGFR3c ligand binding and activation 5 8.00e-01 6.56e-02 8.67e-01
RIPK1-mediated regulated necrosis 31 5.29e-01 6.54e-02 6.63e-01
Regulation of necroptotic cell death 31 5.29e-01 6.54e-02 6.63e-01
CHL1 interactions 8 7.49e-01 -6.52e-02 8.33e-01
Reelin signalling pathway 5 8.01e-01 6.51e-02 8.68e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 6.25e-01 6.48e-02 7.40e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 6.34e-01 6.47e-02 7.44e-01
Hydrolysis of LPC 8 7.52e-01 -6.45e-02 8.33e-01
RHO GTPases activate KTN1 11 7.12e-01 6.43e-02 8.06e-01
Cytoprotection by HMOX1 53 4.19e-01 -6.42e-02 5.72e-01
Regulation of PTEN gene transcription 59 3.94e-01 -6.41e-02 5.53e-01
MET promotes cell motility 33 5.24e-01 -6.41e-02 6.61e-01
EGFR downregulation 27 5.65e-01 -6.41e-02 6.93e-01
Lysine catabolism 11 7.16e-01 -6.33e-02 8.09e-01
FasL/ CD95L signaling 5 8.07e-01 6.32e-02 8.71e-01
Nucleotide-like (purinergic) receptors 13 6.97e-01 6.24e-02 7.95e-01
Sialic acid metabolism 28 5.68e-01 6.24e-02 6.96e-01
Regulation of endogenous retroelements 92 3.02e-01 -6.22e-02 4.59e-01
Transport of small molecules 558 1.28e-02 -6.17e-02 4.19e-02
CRMPs in Sema3A signaling 13 7.01e-01 6.15e-02 7.97e-01
Proton-coupled monocarboxylate transport 6 7.94e-01 -6.14e-02 8.64e-01
Vpr-mediated nuclear import of PICs 34 5.42e-01 -6.05e-02 6.74e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 7.30e-01 6.02e-02 8.20e-01
Regulation of lipid metabolism by PPARalpha 107 2.84e-01 5.99e-02 4.40e-01
Kinesins 51 4.59e-01 -5.99e-02 6.06e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 4.38e-01 5.99e-02 5.88e-01
Inflammasomes 21 6.35e-01 5.98e-02 7.44e-01
Translocation of ZAP-70 to Immunological synapse 24 6.13e-01 5.96e-02 7.33e-01
TNF signaling 56 4.42e-01 5.94e-02 5.92e-01
Nitric oxide stimulates guanylate cyclase 15 6.91e-01 -5.92e-02 7.90e-01
Beta-oxidation of very long chain fatty acids 11 7.34e-01 -5.91e-02 8.22e-01
Intraflagellar transport 47 4.85e-01 -5.89e-02 6.31e-01
Signaling by VEGF 100 3.10e-01 -5.88e-02 4.67e-01
MyD88-independent TLR4 cascade 108 2.92e-01 5.87e-02 4.48e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 2.92e-01 5.87e-02 4.48e-01
Signalling to RAS 19 6.58e-01 5.86e-02 7.62e-01
Regulated Necrosis 56 4.51e-01 -5.83e-02 5.99e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 8.05e-01 5.82e-02 8.71e-01
Acyl chain remodelling of PI 10 7.51e-01 5.78e-02 8.33e-01
Phase 3 - rapid repolarisation 6 8.07e-01 5.77e-02 8.71e-01
Synthesis of pyrophosphates in the cytosol 8 7.77e-01 -5.77e-02 8.53e-01
TCF dependent signaling in response to WNT 153 2.18e-01 -5.77e-02 3.62e-01
LTC4-CYSLTR mediated IL4 production 5 8.24e-01 -5.73e-02 8.82e-01
G beta:gamma signalling through CDC42 17 6.83e-01 -5.71e-02 7.82e-01
Non-integrin membrane-ECM interactions 51 4.82e-01 -5.69e-02 6.29e-01
Generation of second messenger molecules 38 5.45e-01 5.68e-02 6.76e-01
Loss of Function of SMAD2/3 in Cancer 7 7.95e-01 5.66e-02 8.64e-01
Sensory processing of sound by outer hair cells of the cochlea 41 5.31e-01 5.66e-02 6.64e-01
Opioid Signalling 75 3.97e-01 5.66e-02 5.56e-01
Maturation of nucleoprotein 9683610 11 7.47e-01 -5.63e-02 8.31e-01
AKT phosphorylates targets in the cytosol 14 7.18e-01 -5.58e-02 8.10e-01
Lewis blood group biosynthesis 14 7.19e-01 5.55e-02 8.11e-01
TNFs bind their physiological receptors 25 6.31e-01 5.55e-02 7.43e-01
Cargo trafficking to the periciliary membrane 47 5.11e-01 -5.54e-02 6.53e-01
Acyl chain remodelling of PG 11 7.52e-01 5.51e-02 8.33e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 6.41e-01 5.50e-02 7.49e-01
Gap junction trafficking and regulation 30 6.03e-01 -5.49e-02 7.24e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 5.58e-01 -5.49e-02 6.88e-01
RHO GTPase cycle 412 5.62e-02 5.48e-02 1.34e-01
Arachidonate metabolism 45 5.25e-01 -5.48e-02 6.61e-01
Cilium Assembly 186 1.99e-01 -5.46e-02 3.40e-01
ARMS-mediated activation 6 8.17e-01 5.45e-02 8.76e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 7.25e-01 5.44e-02 8.16e-01
Anchoring of the basal body to the plasma membrane 97 3.56e-01 -5.43e-02 5.14e-01
Activation of kainate receptors upon glutamate binding 26 6.33e-01 5.41e-02 7.43e-01
Tie2 Signaling 16 7.09e-01 5.39e-02 8.05e-01
WNT mediated activation of DVL 8 7.92e-01 5.38e-02 8.64e-01
Signaling by NTRKs 117 3.16e-01 5.36e-02 4.72e-01
Death Receptor Signaling 145 2.68e-01 5.33e-02 4.22e-01
Relaxin receptors 5 8.39e-01 5.25e-02 8.92e-01
Toll-like Receptor Cascades 162 2.51e-01 5.22e-02 4.03e-01
GPER1 signaling 38 5.78e-01 -5.21e-02 7.04e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 4.07e-01 -5.21e-02 5.62e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 4.07e-01 -5.21e-02 5.62e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 4.07e-01 -5.21e-02 5.62e-01
Formation of WDR5-containing histone-modifying complexes 42 5.61e-01 5.19e-02 6.91e-01
RSV-host interactions 78 4.31e-01 -5.16e-02 5.83e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 5.94e-01 5.13e-02 7.17e-01
TP53 Regulates Transcription of Cell Death Genes 43 5.64e-01 5.09e-02 6.92e-01
Ephrin signaling 18 7.11e-01 5.05e-02 8.06e-01
Glycerophospholipid biosynthesis 105 3.74e-01 -5.02e-02 5.33e-01
NS1 Mediated Effects on Host Pathways 40 5.88e-01 -4.95e-02 7.13e-01
Toll Like Receptor 3 (TLR3) Cascade 104 3.83e-01 4.95e-02 5.42e-01
Attenuation phase 23 6.83e-01 -4.92e-02 7.82e-01
Transcriptional Regulation by VENTX 39 5.95e-01 4.92e-02 7.17e-01
RUNX2 regulates bone development 26 6.64e-01 4.92e-02 7.65e-01
Prolonged ERK activation events 13 7.60e-01 -4.89e-02 8.40e-01
SHC-mediated cascade:FGFR4 11 7.81e-01 4.84e-02 8.55e-01
Integrin cell surface interactions 68 4.92e-01 4.82e-02 6.36e-01
Immune System 1841 6.29e-04 -4.81e-02 3.11e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 7.73e-01 4.80e-02 8.51e-01
RHOB GTPase cycle 65 5.05e-01 4.79e-02 6.48e-01
Negative regulation of MAPK pathway 42 5.93e-01 -4.76e-02 7.17e-01
Blood group systems biosynthesis 18 7.28e-01 4.73e-02 8.19e-01
Gene expression (Transcription) 1413 2.91e-03 -4.73e-02 1.20e-02
Metabolism of lipids 642 4.21e-02 -4.70e-02 1.08e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 4.17e-01 4.70e-02 5.71e-01
Visual phototransduction 60 5.30e-01 -4.69e-02 6.64e-01
Signaling by CSF3 (G-CSF) 29 6.63e-01 4.67e-02 7.65e-01
Diseases of glycosylation 109 4.00e-01 -4.67e-02 5.57e-01
SHC1 events in ERBB2 signaling 17 7.40e-01 4.66e-02 8.25e-01
PPARA activates gene expression 105 4.10e-01 4.65e-02 5.64e-01
SOS-mediated signalling 7 8.32e-01 4.64e-02 8.87e-01
Export of Viral Ribonucleoproteins from Nucleus 33 6.45e-01 -4.64e-02 7.52e-01
MAP kinase activation 63 5.26e-01 -4.62e-02 6.61e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 4.09e-01 4.60e-02 5.63e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 4.09e-01 4.60e-02 5.63e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 7.29e-01 -4.60e-02 8.19e-01
Signaling by FGFR1 42 6.07e-01 4.59e-02 7.27e-01
Metabolism of fat-soluble vitamins 28 6.74e-01 -4.59e-02 7.73e-01
Signaling by NOTCH1 68 5.13e-01 4.58e-02 6.55e-01
MITF-M-dependent gene expression 83 4.71e-01 4.58e-02 6.18e-01
Nuclear Pore Complex (NPC) Disassembly 36 6.35e-01 -4.57e-02 7.44e-01
Signaling by NOTCH3 44 6.00e-01 -4.56e-02 7.22e-01
PIP3 activates AKT signaling 235 2.29e-01 -4.55e-02 3.76e-01
Alpha-protein kinase 1 signaling pathway 11 7.94e-01 -4.54e-02 8.64e-01
Chromatin modifying enzymes 215 2.52e-01 4.53e-02 4.03e-01
Chromatin organization 215 2.52e-01 4.53e-02 4.03e-01
MyD88 dependent cascade initiated on endosome 101 4.32e-01 4.52e-02 5.83e-01
Signaling by TGFB family members 139 3.62e-01 4.48e-02 5.19e-01
RAF/MAP kinase cascade 226 2.46e-01 -4.48e-02 3.97e-01
Signaling by Insulin receptor 63 5.39e-01 -4.47e-02 6.71e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 7.43e-01 -4.46e-02 8.28e-01
FRS-mediated FGFR1 signaling 15 7.65e-01 4.46e-02 8.45e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 7.75e-01 4.41e-02 8.51e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 6.58e-01 4.39e-02 7.62e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 5.75e-01 -4.37e-02 7.01e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 5.75e-01 -4.37e-02 7.01e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 5.75e-01 -4.37e-02 7.01e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 5.75e-01 -4.37e-02 7.01e-01
Signaling by NOTCH1 in Cancer 55 5.75e-01 -4.37e-02 7.01e-01
Phospholipase C-mediated cascade: FGFR1 8 8.31e-01 4.35e-02 8.87e-01
L1CAM interactions 100 4.53e-01 -4.34e-02 6.01e-01
Signaling by FGFR in disease 52 5.89e-01 -4.33e-02 7.14e-01
Aquaporin-mediated transport 38 6.45e-01 4.32e-02 7.52e-01
Signaling by NTRK1 (TRKA) 102 4.52e-01 4.31e-02 6.00e-01
Signaling by Interleukins 391 1.47e-01 4.27e-02 2.75e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 4.51e-01 4.26e-02 5.99e-01
NPAS4 regulates expression of target genes 16 7.69e-01 4.24e-02 8.47e-01
RHOJ GTPase cycle 50 6.04e-01 -4.23e-02 7.25e-01
Gap junction degradation 11 8.09e-01 -4.20e-02 8.73e-01
Attachment and Entry 9694614 14 7.86e-01 4.19e-02 8.59e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 8.49e-01 -4.17e-02 8.99e-01
Toll Like Receptor 9 (TLR9) Cascade 108 4.61e-01 4.11e-02 6.07e-01
Epigenetic regulation of gene expression 263 2.57e-01 -4.06e-02 4.10e-01
Rap1 signalling 14 7.93e-01 4.05e-02 8.64e-01
RHOG GTPase cycle 71 5.58e-01 -4.02e-02 6.87e-01
Peptide ligand-binding receptors 101 4.86e-01 4.01e-02 6.32e-01
FOXO-mediated transcription 58 5.97e-01 4.01e-02 7.19e-01
Activated point mutants of FGFR2 7 8.55e-01 3.99e-02 9.03e-01
Evasion by RSV of host interferon responses 20 7.58e-01 3.98e-02 8.38e-01
SUMOylation of immune response proteins 12 8.12e-01 3.97e-02 8.74e-01
Elevation of cytosolic Ca2+ levels 13 8.04e-01 -3.97e-02 8.71e-01
Toll Like Receptor 2 (TLR2) Cascade 109 4.76e-01 3.95e-02 6.23e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 4.76e-01 3.95e-02 6.23e-01
Retinoid metabolism and transport 25 7.33e-01 3.94e-02 8.21e-01
MAPK3 (ERK1) activation 10 8.30e-01 3.93e-02 8.86e-01
MAPK1/MAPK3 signaling 232 3.02e-01 -3.93e-02 4.59e-01
FRS-mediated FGFR3 signaling 12 8.14e-01 3.92e-02 8.75e-01
CaMK IV-mediated phosphorylation of CREB 9 8.39e-01 3.91e-02 8.92e-01
RNA Polymerase II Transcription 1206 2.25e-02 -3.90e-02 6.56e-02
Chemokine receptors bind chemokines 39 6.74e-01 3.89e-02 7.73e-01
p75 NTR receptor-mediated signalling 89 5.26e-01 -3.89e-02 6.61e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 6.06e-01 -3.89e-02 7.26e-01
RAF activation 33 7.01e-01 -3.86e-02 7.97e-01
Glycogen breakdown (glycogenolysis) 12 8.18e-01 3.83e-02 8.77e-01
Retrograde transport at the Trans-Golgi-Network 49 6.46e-01 -3.80e-02 7.52e-01
RAC3 GTPase cycle 88 5.38e-01 3.80e-02 6.71e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 7.94e-01 3.76e-02 8.64e-01
SUMOylation of transcription cofactors 44 6.66e-01 -3.76e-02 7.66e-01
Peptide hormone metabolism 54 6.33e-01 3.75e-02 7.43e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 7.15e-01 -3.73e-02 8.08e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 7.15e-01 -3.73e-02 8.08e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 8.48e-01 -3.70e-02 8.98e-01
Signaling by WNT 241 3.27e-01 -3.67e-02 4.83e-01
VEGFA-VEGFR2 Pathway 93 5.53e-01 -3.56e-02 6.82e-01
Uptake and actions of bacterial toxins 28 7.45e-01 3.55e-02 8.30e-01
ERBB2 Regulates Cell Motility 10 8.47e-01 3.53e-02 8.98e-01
ADP signalling through P2Y purinoceptor 1 21 7.81e-01 -3.50e-02 8.55e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 1.36e-01 -3.50e-02 2.59e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 8.92e-01 -3.49e-02 9.33e-01
Collagen formation 66 6.26e-01 3.47e-02 7.41e-01
STING mediated induction of host immune responses 15 8.16e-01 -3.47e-02 8.76e-01
FGFR1 ligand binding and activation 10 8.51e-01 -3.44e-02 9.00e-01
RHOC GTPase cycle 72 6.15e-01 3.43e-02 7.34e-01
RA biosynthesis pathway 13 8.30e-01 -3.43e-02 8.87e-01
Serine biosynthesis 8 8.67e-01 3.43e-02 9.11e-01
Intra-Golgi traffic 43 6.98e-01 -3.42e-02 7.95e-01
ESR-mediated signaling 160 4.55e-01 -3.42e-02 6.03e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 8.11e-01 -3.36e-02 8.74e-01
Nicotinate metabolism 26 7.68e-01 3.35e-02 8.47e-01
Apoptotic cleavage of cellular proteins 35 7.33e-01 -3.33e-02 8.21e-01
RAF-independent MAPK1/3 activation 22 7.87e-01 3.33e-02 8.59e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 8.71e-01 3.33e-02 9.14e-01
RHOH GTPase cycle 34 7.41e-01 3.28e-02 8.26e-01
Signaling by FGFR4 32 7.52e-01 -3.22e-02 8.33e-01
Extracellular matrix organization 222 4.08e-01 3.22e-02 5.63e-01
TICAM1-dependent activation of IRF3/IRF7 13 8.41e-01 3.20e-02 8.94e-01
CD163 mediating an anti-inflammatory response 9 8.68e-01 3.20e-02 9.11e-01
Interleukin-17 signaling 68 6.48e-01 -3.20e-02 7.54e-01
Glycosaminoglycan metabolism 98 5.85e-01 -3.20e-02 7.11e-01
RHOA GTPase cycle 139 5.18e-01 3.18e-02 6.57e-01
FOXO-mediated transcription of cell death genes 16 8.28e-01 3.14e-02 8.85e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 6.63e-01 -3.10e-02 7.65e-01
Activation of NMDA receptors and postsynaptic events 74 6.46e-01 3.09e-02 7.52e-01
Cellular responses to mechanical stimuli 82 6.30e-01 -3.08e-02 7.42e-01
Response of endothelial cells to shear stress 82 6.30e-01 -3.08e-02 7.42e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.72e-01 -3.02e-02 7.00e-01
Phospholipase C-mediated cascade; FGFR3 5 9.07e-01 3.01e-02 9.43e-01
Defective RIPK1-mediated regulated necrosis 7 8.91e-01 2.99e-02 9.32e-01
Activation of the AP-1 family of transcription factors 10 8.71e-01 2.96e-02 9.14e-01
Signaling by ERBB2 44 7.35e-01 -2.95e-02 8.23e-01
HSF1-dependent transactivation 30 7.81e-01 -2.93e-02 8.55e-01
Signaling by EGFR 48 7.27e-01 2.91e-02 8.18e-01
Signaling by Activin 14 8.51e-01 -2.90e-02 9.01e-01
Reduction of cytosolic Ca++ levels 9 8.81e-01 2.89e-02 9.23e-01
Extra-nuclear estrogen signaling 67 6.83e-01 -2.88e-02 7.82e-01
GABA synthesis, release, reuptake and degradation 12 8.64e-01 2.85e-02 9.09e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.64e-01 -2.85e-02 9.09e-01
alpha-linolenic acid (ALA) metabolism 12 8.64e-01 -2.85e-02 9.09e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 7.39e-01 2.84e-02 8.25e-01
Molecules associated with elastic fibres 26 8.04e-01 -2.81e-02 8.71e-01
Signaling by Rho GTPases 608 2.41e-01 -2.79e-02 3.91e-01
Formation of the beta-catenin:TCF transactivating complex 44 7.50e-01 -2.77e-02 8.33e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 7.33e-01 2.73e-02 8.21e-01
Oncogene Induced Senescence 33 7.90e-01 2.68e-02 8.62e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.53e-01 -2.67e-02 9.02e-01
Post-translational protein phosphorylation 70 7.00e-01 -2.67e-02 7.97e-01
Formation of the cornified envelope 36 7.83e-01 -2.65e-02 8.57e-01
Glucagon-type ligand receptors 20 8.41e-01 -2.58e-02 8.94e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 7.89e-01 2.58e-02 8.61e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 9.13e-01 -2.58e-02 9.47e-01
VEGFR2 mediated vascular permeability 26 8.21e-01 -2.57e-02 8.78e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 7.60e-01 -2.55e-02 8.40e-01
Signal Transduction 2058 5.75e-02 2.54e-02 1.37e-01
G alpha (i) signalling events 194 5.44e-01 2.53e-02 6.75e-01
TAK1-dependent IKK and NF-kappa-B activation 43 7.75e-01 2.52e-02 8.51e-01
FGFR4 ligand binding and activation 5 9.22e-01 -2.52e-02 9.53e-01
Signaling by Retinoic Acid 29 8.15e-01 -2.52e-02 8.75e-01
Mitochondrial unfolded protein response (UPRmt) 17 8.60e-01 -2.46e-02 9.06e-01
The canonical retinoid cycle in rods (twilight vision) 9 8.99e-01 -2.45e-02 9.36e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 8.21e-01 2.39e-02 8.78e-01
Signaling by Nuclear Receptors 214 5.47e-01 -2.39e-02 6.78e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 8.54e-01 2.38e-02 9.02e-01
Trafficking of AMPA receptors 20 8.54e-01 2.38e-02 9.02e-01
RAB GEFs exchange GTP for GDP on RABs 89 6.98e-01 -2.38e-02 7.95e-01
Common Pathway of Fibrin Clot Formation 13 8.84e-01 2.34e-02 9.26e-01
Elastic fibre formation 33 8.16e-01 2.34e-02 8.76e-01
Generic Transcription Pathway 1088 1.95e-01 -2.33e-02 3.37e-01
Rab regulation of trafficking 122 6.58e-01 -2.32e-02 7.62e-01
RHOD GTPase cycle 50 7.82e-01 2.27e-02 8.55e-01
EPHA-mediated growth cone collapse 21 8.59e-01 2.23e-02 9.06e-01
IFNG signaling activates MAPKs 8 9.16e-01 -2.14e-02 9.49e-01
Biosynthesis of Lipoxins (LX) 6 9.28e-01 -2.13e-02 9.57e-01
EPH-ephrin mediated repulsion of cells 43 8.09e-01 -2.13e-02 8.73e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 9.35e-01 -2.09e-02 9.62e-01
Factors involved in megakaryocyte development and platelet production 129 6.92e-01 2.02e-02 7.90e-01
SHC-mediated cascade:FGFR1 13 9.00e-01 2.02e-02 9.37e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 8.58e-01 -1.99e-02 9.05e-01
Collagen biosynthesis and modifying enzymes 48 8.14e-01 1.96e-02 8.75e-01
RHO GTPases Activate ROCKs 18 8.86e-01 -1.94e-02 9.28e-01
SLC transporter disorders 77 7.71e-01 -1.92e-02 8.50e-01
p38MAPK events 13 9.06e-01 1.89e-02 9.42e-01
Cell death signalling via NRAGE, NRIF and NADE 69 7.93e-01 -1.83e-02 8.64e-01
Signaling by FGFR3 32 8.60e-01 -1.80e-02 9.06e-01
FGFR1b ligand binding and activation 5 9.45e-01 1.78e-02 9.71e-01
RHOQ GTPase cycle 55 8.33e-01 -1.65e-02 8.88e-01
Intracellular signaling by second messengers 268 6.43e-01 -1.64e-02 7.51e-01
IKK complex recruitment mediated by RIP1 23 8.96e-01 -1.58e-02 9.35e-01
Negative regulation of FLT3 15 9.16e-01 -1.58e-02 9.49e-01
The NLRP3 inflammasome 16 9.13e-01 -1.58e-02 9.47e-01
Interleukin-27 signaling 11 9.29e-01 -1.55e-02 9.57e-01
Inactivation of CSF3 (G-CSF) signaling 24 8.96e-01 -1.55e-02 9.35e-01
Post NMDA receptor activation events 64 8.35e-01 1.51e-02 8.89e-01
Semaphorin interactions 56 8.48e-01 -1.48e-02 8.98e-01
Digestion 5 9.54e-01 -1.48e-02 9.75e-01
Platelet homeostasis 69 8.34e-01 -1.46e-02 8.89e-01
G beta:gamma signalling through PI3Kgamma 22 9.06e-01 -1.45e-02 9.42e-01
MyD88 cascade initiated on plasma membrane 95 8.07e-01 1.45e-02 8.71e-01
Toll Like Receptor 10 (TLR10) Cascade 95 8.07e-01 1.45e-02 8.71e-01
Toll Like Receptor 5 (TLR5) Cascade 95 8.07e-01 1.45e-02 8.71e-01
Cytokine Signaling in Immune system 670 5.25e-01 -1.44e-02 6.61e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 9.16e-01 -1.43e-02 9.49e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 9.16e-01 -1.43e-02 9.49e-01
Signaling by NOTCH2 33 8.87e-01 1.43e-02 9.29e-01
Maturation of nucleoprotein 9694631 15 9.24e-01 -1.42e-02 9.55e-01
Scavenging by Class F Receptors 5 9.56e-01 1.41e-02 9.77e-01
Cobalamin (Cbl) metabolism 7 9.49e-01 1.40e-02 9.72e-01
Signaling by MAPK mutants 6 9.53e-01 -1.39e-02 9.75e-01
G-protein beta:gamma signalling 29 8.98e-01 1.37e-02 9.36e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 8.34e-01 -1.36e-02 8.89e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.47e-01 -1.36e-02 9.71e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 9.48e-01 -1.34e-02 9.71e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.52e-01 1.33e-02 9.74e-01
FGFR2 ligand binding and activation 9 9.46e-01 1.31e-02 9.71e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 8.15e-01 -1.31e-02 8.75e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 8.99e-01 -1.30e-02 9.36e-01
Transport of fatty acids 5 9.61e-01 -1.27e-02 9.78e-01
Synthesis of UDP-N-acetyl-glucosamine 8 9.51e-01 1.25e-02 9.74e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 9.21e-01 1.23e-02 9.53e-01
Platelet calcium homeostasis 22 9.25e-01 -1.16e-02 9.55e-01
SLC-mediated transmembrane transport 175 7.97e-01 -1.13e-02 8.66e-01
Signaling by TGF-beta Receptor Complex 91 8.57e-01 -1.09e-02 9.04e-01
SUMO E3 ligases SUMOylate target proteins 161 8.13e-01 1.08e-02 8.75e-01
G alpha (z) signalling events 36 9.12e-01 1.07e-02 9.47e-01
MAPK family signaling cascades 264 7.68e-01 -1.05e-02 8.47e-01
Passive transport by Aquaporins 6 9.65e-01 1.04e-02 9.79e-01
Keratan sulfate/keratin metabolism 28 9.25e-01 1.03e-02 9.55e-01
Phase I - Functionalization of compounds 70 8.91e-01 -9.46e-03 9.32e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 9.61e-01 -9.37e-03 9.78e-01
Signalling to ERKs 32 9.32e-01 8.73e-03 9.60e-01
Signaling by ERBB4 45 9.21e-01 -8.52e-03 9.53e-01
Interleukin-35 Signalling 12 9.61e-01 8.16e-03 9.78e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.75e-01 -7.97e-03 9.84e-01
Induction of Cell-Cell Fusion 8 9.70e-01 7.72e-03 9.83e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 9.75e-01 -7.44e-03 9.84e-01
Pre-NOTCH Transcription and Translation 47 9.32e-01 7.15e-03 9.60e-01
Calcineurin activates NFAT 9 9.72e-01 6.79e-03 9.84e-01
Trafficking and processing of endosomal TLR 13 9.67e-01 -6.64e-03 9.80e-01
Metabolism of steroids 125 9.00e-01 -6.49e-03 9.37e-01
SHC-mediated cascade:FGFR3 10 9.72e-01 6.43e-03 9.84e-01
Triglyceride catabolism 16 9.65e-01 6.37e-03 9.79e-01
Keratinization 37 9.47e-01 -6.27e-03 9.71e-01
ECM proteoglycans 48 9.40e-01 6.24e-03 9.67e-01
ERK/MAPK targets 22 9.61e-01 -6.07e-03 9.78e-01
Cargo concentration in the ER 31 9.54e-01 5.96e-03 9.75e-01
Metal ion SLC transporters 19 9.65e-01 -5.81e-03 9.79e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.74e-01 5.76e-03 9.84e-01
RHO GTPases activate PAKs 20 9.65e-01 5.71e-03 9.79e-01
ChREBP activates metabolic gene expression 7 9.80e-01 5.56e-03 9.88e-01
Signaling by Receptor Tyrosine Kinases 449 8.44e-01 -5.43e-03 8.96e-01
Synthesis of PA 31 9.59e-01 5.31e-03 9.78e-01
MITF-M-regulated melanocyte development 113 9.26e-01 5.03e-03 9.56e-01
TBC/RABGAPs 45 9.58e-01 -4.52e-03 9.78e-01
ADORA2B mediated anti-inflammatory cytokines production 36 9.63e-01 -4.43e-03 9.79e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 9.76e-01 -4.28e-03 9.84e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 9.76e-01 -4.28e-03 9.84e-01
HDR through MMEJ (alt-NHEJ) 12 9.81e-01 -4.05e-03 9.88e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 9.80e-01 -3.95e-03 9.88e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 9.86e-01 3.85e-03 9.92e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 9.88e-01 3.58e-03 9.93e-01
TGFBR1 KD Mutants in Cancer 6 9.88e-01 3.58e-03 9.93e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 9.73e-01 -3.54e-03 9.84e-01
Signaling by MET 68 9.66e-01 2.96e-03 9.80e-01
SUMOylation 167 9.61e-01 2.21e-03 9.78e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 9.46e-01 -1.95e-03 9.71e-01
RND1 GTPase cycle 37 9.84e-01 1.92e-03 9.90e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 9.91e-01 1.72e-03 9.94e-01
Cellular hexose transport 14 9.92e-01 -1.54e-03 9.95e-01
Zinc influx into cells by the SLC39 gene family 9 9.94e-01 1.49e-03 9.96e-01
Pre-NOTCH Expression and Processing 63 9.84e-01 1.48e-03 9.90e-01
N-Glycan antennae elongation 13 9.93e-01 1.47e-03 9.95e-01
Interferon gamma signaling 90 9.91e-01 -7.15e-04 9.94e-01
Erythropoietin activates STAT5 6 9.98e-01 5.15e-04 9.99e-01
Estrogen-dependent gene expression 97 9.97e-01 -2.27e-04 9.98e-01
Formation of the nephric duct 8 9.99e-01 1.93e-04 1.00e+00
Phosphate bond hydrolysis by NTPDase proteins 5 1.00e+00 -9.09e-05 1.00e+00


Detailed Gene set reports



Formation of ATP by chemiosmotic coupling
set Formation of ATP by chemiosmotic coupling
setSize 20
pANOVA 3.91e-11
s.dist -0.853
p.adjustANOVA 6.75e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5MK -10380
ATP5MG -10105
ATP5F1C -10017
ATP5F1E -10002
ATP5MC1 -9957
ATP5PO -9871
ATP5PB -9735
ATP5PD -9684
ATP5PF -9668
ATP5F1A -9449
ATP5F1B -9413
ATP5MC2 -9311
MT-ATP6 -8914
ATP5MF -8779
ATP5MJ -8413
ATP5MC3 -8106
DMAC2L -8048
ATP5F1D -7280
ATP5ME -5434
MT-ATP8 -5197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MK -10380
ATP5MG -10105
ATP5F1C -10017
ATP5F1E -10002
ATP5MC1 -9957
ATP5PO -9871
ATP5PB -9735
ATP5PD -9684
ATP5PF -9668
ATP5F1A -9449
ATP5F1B -9413
ATP5MC2 -9311
MT-ATP6 -8914
ATP5MF -8779
ATP5MJ -8413
ATP5MC3 -8106
DMAC2L -8048
ATP5F1D -7280
ATP5ME -5434
MT-ATP8 -5197


Peptide chain elongation
set Peptide chain elongation
setSize 88
pANOVA 1.15e-42
s.dist -0.843
p.adjustANOVA 1.31e-40


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
EEF1A1 -9700
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EEF2 -7220
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
RPL9 -211
RPL3L 555
RPS26 7854


Formation of a pool of free 40S subunits
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 3.11e-48
s.dist -0.842
p.adjustANOVA 4.29e-46


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
EIF3E -9856
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
EIF3K -9764
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
EIF3I -9539
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
EIF3L -9326
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPL36AL -6619
RPS16 -6449
EIF1AX -6420
RPL9 -211
RPL3L 555
RPS26 7854


Eukaryotic Translation Elongation
set Eukaryotic Translation Elongation
setSize 93
pANOVA 3.7e-44
s.dist -0.834
p.adjustANOVA 4.47e-42


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
EEF1A1 -9700
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
EEF1B2 -9600
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
EEF1G -9229
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
EEF1A1P5 -8839
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
RPS2 -7850
EEF1D -7498
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EEF2 -7220
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
RPL9 -211
EEF1A2 -106
RPL3L 555
RPS26 7854


Viral mRNA Translation
set Viral mRNA Translation
setSize 88
pANOVA 1.49e-41
s.dist -0.831
p.adjustANOVA 1.6e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
GRSF1 -9526
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
RPL9 -211
RPL3L 555
DNAJC3 3670
RPS26 7854


L13a-mediated translational silencing of Ceruloplasmin expression
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 6.07e-51
s.dist -0.826
p.adjustANOVA 1.17e-48


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
EIF3E -9856
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
EIF3K -9764
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
EIF3I -9539
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
EIF4A1 -9231
RPS19 -9142
RPL23A -9124
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPL36AL -6619
RPS16 -6449
EIF1AX -6420
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
RPL9 -211
RPL3L 555
EIF4G1 781
RPS26 7854


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.000153
s.dist -0.826
p.adjustANOVA 0.000877


Top enriched genes
Top 20 genes
GeneID Gene Rank
B2M -10300
UBC -9922
UBA52 -9493
RPS27A -9093
MRC1 -8238
TLR2 -7510
UBB -5642

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B2M -10300
UBC -9922
UBA52 -9493
RPS27A -9093
MRC1 -8238
TLR2 -7510
UBB -5642


GTP hydrolysis and joining of the 60S ribosomal subunit
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 7.36e-51
s.dist -0.822
p.adjustANOVA 1.29e-48


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
EIF3E -9856
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
EIF3K -9764
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
EIF3I -9539
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
EIF4A1 -9231
RPS19 -9142
RPL23A -9124
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
RPL38 -8566
EIF5 -8531
RPL39L -8440
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPL36AL -6619
RPS16 -6449
EIF1AX -6420
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
EIF5B -4212
RPL9 -211
RPL3L 555
EIF4G1 781
RPS26 7854


SARS-CoV-1 modulates host translation machinery
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 1.72e-17
s.dist -0.819
p.adjustANOVA 5.93e-16


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
RPS24 -9902
RPS15A -9864
RPS6 -9825
RPS23 -9737
EEF1A1 -9700
RPS27 -9690
RPSA -9568
RPS9 -9546
RPS3 -9514
RPS11 -9343
RPS10 -9274
RPS19 -9142
RPS27A -9093

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
RPS24 -9902
RPS15A -9864
RPS6 -9825
RPS23 -9737
EEF1A1 -9700
RPS27 -9690
RPSA -9568
RPS9 -9546
RPS3 -9514
RPS11 -9343
RPS10 -9274
RPS19 -9142
RPS27A -9093
HNRNPA1 -9026
FAU -8965
RPS15 -8796
RPS27L -8746
RPS17 -8643
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPS14 -8103
RPS2 -7850
RPS29 -7205
RPS4Y1 -7140
RPS21 -6830
RPS28 -6699
RPS16 -6449
RPS26 7854


Cap-dependent Translation Initiation
set Cap-dependent Translation Initiation
setSize 118
pANOVA 2.87e-53
s.dist -0.817
p.adjustANOVA 6.17e-51


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
EIF3E -9856
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
EIF3K -9764
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
EIF3I -9539
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
EIF4A1 -9231
RPS19 -9142
RPL23A -9124
RPS27A -9093
EIF3D -9077
EIF2B2 -9053
FAU -8965
EIF3G -8962
EIF3J -8886
RPL3 -8849
EIF2B1 -8805
RPS15 -8796
RPL26L1 -8789
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
RPL38 -8566
EIF5 -8531
RPL39L -8440
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPL36AL -6619
RPS16 -6449
EIF1AX -6420
EIF2B3 -6024
EIF2B4 -5452
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
EIF5B -4212
EIF2B5 -3131
RPL9 -211
RPL3L 555
EIF4G1 781
RPS26 7854


Eukaryotic Translation Initiation
set Eukaryotic Translation Initiation
setSize 118
pANOVA 2.87e-53
s.dist -0.817
p.adjustANOVA 6.17e-51


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
EIF3E -9856
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
EIF3K -9764
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
EIF3I -9539
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
EIF4A1 -9231
RPS19 -9142
RPL23A -9124
RPS27A -9093
EIF3D -9077
EIF2B2 -9053
FAU -8965
EIF3G -8962
EIF3J -8886
RPL3 -8849
EIF2B1 -8805
RPS15 -8796
RPL26L1 -8789
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
RPL38 -8566
EIF5 -8531
RPL39L -8440
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPL36AL -6619
RPS16 -6449
EIF1AX -6420
EIF2B3 -6024
EIF2B4 -5452
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
EIF5B -4212
EIF2B5 -3131
RPL9 -211
RPL3L 555
EIF4G1 781
RPS26 7854


Formation of the ternary complex, and subsequently, the 43S complex
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 9.14e-24
s.dist -0.813
p.adjustANOVA 3.92e-22


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
RPSA -9568
RPS9 -9546
EIF3I -9539
RPS3 -9514

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
RPSA -9568
RPS9 -9546
EIF3I -9539
RPS3 -9514
RPS11 -9343
EIF3L -9326
RPS10 -9274
RPS19 -9142
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPS15 -8796
EIF2S3 -8788
RPS27L -8746
RPS17 -8643
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPS16 -6449
EIF1AX -6420
EIF2S1 -4353
RPS26 7854


Eukaryotic Translation Termination
set Eukaryotic Translation Termination
setSize 92
pANOVA 2.94e-41
s.dist -0.81
p.adjustANOVA 2.84e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
TRMT112 -9206
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
APEH -8186
RPL37 -8134
RPS14 -8103
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
GSPT1 -2718
ETF1 -2338
GSPT2 -1663
RPL9 -211
RPL3L 555
N6AMT1 5290
RPS26 7854


Mitochondrial translation initiation
set Mitochondrial translation initiation
setSize 90
pANOVA 4.03e-40
s.dist -0.807
p.adjustANOVA 3.24e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
MTIF2 -9775
MRPL11 -9724

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
MTIF2 -9775
MRPL11 -9724
MRPL45 -9715
MRPL12 -9705
MRPL48 -9657
MRPL46 -9617
MRPL20 -9598
CHCHD1 -9555
MRPS27 -9511
MRPS18B -9491
MRPL44 -9484
MRPS18C -9473
MRPL16 -9445
GADD45GIP1 -9421
MRPL52 -9360
MRPL24 -9310
MRPL36 -9299
MRPL54 -9275
MRPS17 -9267
MRPS11 -9136
MRPL53 -9120
MRPS35 -9047
MRPL58 -9021
MRPS5 -9020
MTIF3 -8994
MRPL27 -8987
OXA1L -8898
MRPL9 -8852
MRPS26 -8776
MRPL18 -8752
MRPS23 -8642
MRPL49 -8603
PTCD3 -8573
MRPL4 -8532
MRPL14 -8517
MRPL47 -8493
MRPS24 -8476
MRPS18A -8450
MRPS2 -8400
MRPL23 -8376
RPS12 -8239
MTFMT -8157
MRPL21 -8109
MRPL55 -8075
MRPS14 -8020
ERAL1 -7967
MRPS34 -7831
MRPL13 -7769
MRPL43 -7618
MRPL22 -7418
MRPL33 -7354
MRPS9 -7312
MRPS30 -7284
MRPL10 -7219
AURKAIP1 -7164
MRPL38 -7021
MRPS33 -7001
MRPL1 -6880
MRPS36 -6782
MRPL19 -6743
MRPS25 -6380
MRPL28 -6206
MRPL30 -6130
MRPS10 -6117
MRPL39 -5938
MRPS31 -5590
MRPL35 -5552
MRPL2 -5522
MRPL41 -5086
MRPL42 -3938
MRPL50 -1530
MRPS6 3567


SRP-dependent cotranslational protein targeting to membrane
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 6.91e-49
s.dist -0.805
p.adjustANOVA 1.03e-46


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
SEC11A -10174
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
SPCS1 -9986
RPL14 -9980
RPL10A -9944

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
SEC11A -10174
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
SPCS1 -9986
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
SSR2 -9870
RPS15A -9864
RPL8 -9829
RPS6 -9825
SSR3 -9815
RPL34 -9794
RPL23 -9782
SRPRB -9773
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
SSR4 -9403
RPL18A -9381
SRP14 -9355
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPN1 -9289
RPS10 -9274
RPL27A -9269
RPN2 -9209
RPS19 -9142
RPL23A -9124
SRP72 -9097
RPS27A -9093
SEC11C -9092
DDOST -9051
FAU -8965
RPL3 -8849
SRP9 -8846
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
SEC61G -8480
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
SEC61A1 -8133
RPS14 -8103
SEC61B -8033
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
TRAM1 -7258
SRP68 -7246
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
SPCS2 -7056
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
SRP19 -4245
SPCS3 -3044
SSR1 -1072
SRP54 -997
RPL9 -211
RPL3L 555
SRPRA 2034
SEC61A2 4644
RPS26 7854


Selenocysteine synthesis
set Selenocysteine synthesis
setSize 92
pANOVA 9.69e-41
s.dist -0.805
p.adjustANOVA 8.14e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
EEFSEC -8495
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
SARS1 -6944
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
SECISBP2 -1782
RPL9 -211
PSTK -117
RPL3L 555
SEPHS2 1630
SEPSECS 2235
RPS26 7854


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 2.37e-41
s.dist -0.802
p.adjustANOVA 2.41e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
NCBP2 -7940
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
GSPT1 -2718
ETF1 -2338
UPF1 -2230
NCBP1 -1910
GSPT2 -1663
RPL9 -211
RPL3L 555
EIF4G1 781
RPS26 7854


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 3.26e-26
s.dist -0.796
p.adjustANOVA 1.54e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
PABPC1 -9588
RPSA -9568
RPS9 -9546

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
PABPC1 -9588
RPSA -9568
RPS9 -9546
EIF3I -9539
RPS3 -9514
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPS10 -9274
EIF4A1 -9231
RPS19 -9142
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPS15 -8796
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPS16 -6449
EIF1AX -6420
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
EIF4G1 781
RPS26 7854


Mitochondrial translation elongation
set Mitochondrial translation elongation
setSize 90
pANOVA 7.27e-39
s.dist -0.794
p.adjustANOVA 4.84e-37


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
TSFM -9744
MRPL11 -9724

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
TSFM -9744
MRPL11 -9724
MRPL45 -9715
MRPL12 -9705
MRPL48 -9657
MRPL46 -9617
MRPL20 -9598
CHCHD1 -9555
MRPS27 -9511
MRPS18B -9491
MRPL44 -9484
MRPS18C -9473
MRPL16 -9445
GADD45GIP1 -9421
MRPL52 -9360
MRPL24 -9310
MRPL36 -9299
MRPL54 -9275
MRPS17 -9267
MRPS11 -9136
MRPL53 -9120
MRPS35 -9047
MRPL58 -9021
MRPS5 -9020
MRPL27 -8987
OXA1L -8898
MRPL9 -8852
MRPS26 -8776
MRPL18 -8752
MRPS23 -8642
TUFM -8625
MRPL49 -8603
PTCD3 -8573
MRPL4 -8532
MRPL14 -8517
MRPL47 -8493
MRPS24 -8476
MRPS18A -8450
MRPS2 -8400
MRPL23 -8376
RPS12 -8239
MRPL21 -8109
MRPL55 -8075
MRPS14 -8020
ERAL1 -7967
MRPS34 -7831
MRPL13 -7769
MRPL43 -7618
MRPL22 -7418
MRPL33 -7354
MRPS9 -7312
MRPS30 -7284
MRPL10 -7219
AURKAIP1 -7164
MRPL38 -7021
MRPS33 -7001
MRPL1 -6880
MRPS36 -6782
MRPL19 -6743
MRPS25 -6380
MRPL28 -6206
MRPL30 -6130
MRPS10 -6117
MRPL39 -5938
MRPS31 -5590
MRPL35 -5552
MRPL2 -5522
MRPL41 -5086
MRPL42 -3938
MRPL50 -1530
MRPS6 3567
GFM1 4522


Translation initiation complex formation
set Translation initiation complex formation
setSize 58
pANOVA 1.32e-25
s.dist -0.793
p.adjustANOVA 6.06e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
PABPC1 -9588
RPSA -9568
RPS9 -9546
EIF3I -9539

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
PABPC1 -9588
RPSA -9568
RPS9 -9546
EIF3I -9539
RPS3 -9514
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPS10 -9274
EIF4A1 -9231
RPS19 -9142
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPS15 -8796
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPS16 -6449
EIF1AX -6420
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
EIF4G1 781
RPS26 7854


Ribosomal scanning and start codon recognition
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 1.66e-25
s.dist -0.791
p.adjustANOVA 7.46e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
RPSA -9568
RPS9 -9546
EIF3I -9539
RPS3 -9514

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10392
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
EIF3H -9904
RPS24 -9902
RPS15A -9864
EIF3E -9856
RPS6 -9825
EIF3K -9764
RPS23 -9737
RPS27 -9690
RPSA -9568
RPS9 -9546
EIF3I -9539
RPS3 -9514
EIF4B -9349
RPS11 -9343
EIF3L -9326
RPS10 -9274
EIF4A1 -9231
RPS19 -9142
RPS27A -9093
EIF3D -9077
FAU -8965
EIF3G -8962
EIF3J -8886
RPS15 -8796
EIF2S3 -8788
RPS27L -8746
EIF4H -8741
RPS17 -8643
EIF5 -8531
RPS5 -8387
EIF3B -8354
RPS18 -8329
RPS12 -8239
RPS14 -8103
EIF2S2 -8035
RPS2 -7850
EIF3C -7214
RPS29 -7205
RPS4Y1 -7140
RPS21 -6830
EIF3A -6825
EIF3F -6730
RPS28 -6699
RPS16 -6449
EIF1AX -6420
EIF4A2 -5246
EIF4E -5067
EIF2S1 -4353
EIF4G1 781
RPS26 7854


Mitochondrial translation termination
set Mitochondrial translation termination
setSize 90
pANOVA 6.58e-38
s.dist -0.783
p.adjustANOVA 4.24e-36


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
MRPL11 -9724
MRPL45 -9715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
MRPL11 -9724
MRPL45 -9715
MRPL12 -9705
MRPL48 -9657
MRPL46 -9617
MRPL20 -9598
CHCHD1 -9555
MRPS27 -9511
MRPS18B -9491
MRPL44 -9484
MRPS18C -9473
MRPL16 -9445
GADD45GIP1 -9421
MRPL52 -9360
MRPL24 -9310
MRPL36 -9299
MRPL54 -9275
MRPS17 -9267
MRPS11 -9136
MRPL53 -9120
MRPS35 -9047
MRPL58 -9021
MRPS5 -9020
MRPL27 -8987
OXA1L -8898
MRPL9 -8852
MRPS26 -8776
MRPL18 -8752
MRRF -8706
MRPS23 -8642
MRPL49 -8603
PTCD3 -8573
MRPL4 -8532
MRPL14 -8517
MRPL47 -8493
MRPS24 -8476
MRPS18A -8450
MRPS2 -8400
MRPL23 -8376
RPS12 -8239
MRPL21 -8109
MRPL55 -8075
MRPS14 -8020
ERAL1 -7967
MRPS34 -7831
MRPL13 -7769
MRPL43 -7618
MRPL22 -7418
MRPL33 -7354
MRPS9 -7312
MRPS30 -7284
MRPL10 -7219
AURKAIP1 -7164
MRPL38 -7021
MRPS33 -7001
MRPL1 -6880
MRPS36 -6782
MRPL19 -6743
MRPS25 -6380
MRPL28 -6206
MRPL30 -6130
MRPS10 -6117
MRPL39 -5938
MRPS31 -5590
MRPL35 -5552
MRPL2 -5522
MRPL41 -5086
MRPL42 -3938
MRPL50 -1530
GFM2 -152
MRPS6 3567
MTRF1L 5120


Mitochondrial translation
set Mitochondrial translation
setSize 96
pANOVA 1.31e-39
s.dist -0.776
p.adjustANOVA 9.37e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
MTIF2 -9775
TSFM -9744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
MRPS15 -10133
MRPL51 -10128
MRPS22 -10101
MRPS7 -10040
DAP3 -10030
MRPL40 -9939
MRPL17 -9915
MRPL32 -9897
MRPL57 -9894
MRPL34 -9812
MTIF2 -9775
TSFM -9744
MRPL11 -9724
MRPL45 -9715
MRPL12 -9705
MRPL48 -9657
MRPL46 -9617
MRPL20 -9598
CHCHD1 -9555
MRPS27 -9511
MRPS18B -9491
MRPL44 -9484
MRPS18C -9473
MRPL16 -9445
GADD45GIP1 -9421
MRPL52 -9360
MRPL24 -9310
MRPL36 -9299
MRPL54 -9275
MRPS17 -9267
MRPS11 -9136
MRPL53 -9120
MRPS35 -9047
MRPL58 -9021
MRPS5 -9020
MTIF3 -8994
MRPL27 -8987
OXA1L -8898
MRPL9 -8852
MRPS26 -8776
MRPL18 -8752
MRRF -8706
MRPS23 -8642
TUFM -8625
MRPL49 -8603
PTCD3 -8573
MRPL4 -8532
MRPL14 -8517
MRPL47 -8493
MRPS24 -8476
MRPS18A -8450
MRPS2 -8400
MRPL23 -8376
RPS12 -8239
MTFMT -8157
MRPL21 -8109
MRPL55 -8075
MRPS14 -8020
ERAL1 -7967
MRPS34 -7831
MRPL13 -7769
MRPL43 -7618
MRPL22 -7418
MRPL33 -7354
MRPS9 -7312
MRPS30 -7284
MRPL10 -7219
AURKAIP1 -7164
MRPL38 -7021
MRPS33 -7001
MRPL1 -6880
MRPS36 -6782
MRPL19 -6743
MRPS25 -6380
MRPL28 -6206
MRPL30 -6130
MRPS10 -6117
MRPL39 -5938
MRPS31 -5590
MRPL35 -5552
MRPL2 -5522
MRPL41 -5086
MRPL42 -3938
MRPL50 -1530
GFM2 -152
MRPS6 3567
GFM1 4522
MTRF1L 5120


Response of EIF2AK4 (GCN2) to amino acid deficiency
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 5.87e-40
s.dist -0.764
p.adjustANOVA 4.39e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
ATF4 -10010
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
ATF4 -10010
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
EIF2AK4 -9399
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
EIF2S3 -8788
RPS27L -8746
RPS17 -8643
RPL38 -8566
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
EIF2S2 -8035
DDIT3 -7887
RPS2 -7850
CEBPG -7797
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RPS21 -6830
RPS28 -6699
RPL36AL -6619
IMPACT -6561
RPS16 -6449
EIF2S1 -4353
TRIB3 -2986
ATF2 -299
RPL9 -211
RPL3L 555
GCN1 5856
CEBPB 7591
RPS26 7854
ATF3 8369
ASNS 8832


Complex III assembly
set Complex III assembly
setSize 23
pANOVA 2.46e-10
s.dist -0.762
p.adjustANOVA 3.71e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
UQCRH -10424
FXN -10243
UQCRC2 -10165
HSCB -10020
UQCRB -9949
LYRM4 -9849
UQCRQ -9529
UQCR11 -9448
CYC1 -8948
UQCRC1 -8809
UQCRFS1 -8742
ISCU -8156
UQCR10 -8058
UQCC2 -7906
UQCC1 -7796
MT-CYB -7734
UQCC3 -7500
TTC19 -6617
BCS1L -6311
HSPA9 -5919

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UQCRH -10424
FXN -10243
UQCRC2 -10165
HSCB -10020
UQCRB -9949
LYRM4 -9849
UQCRQ -9529
UQCR11 -9448
CYC1 -8948
UQCRC1 -8809
UQCRFS1 -8742
ISCU -8156
UQCR10 -8058
UQCC2 -7906
UQCC1 -7796
MT-CYB -7734
UQCC3 -7500
TTC19 -6617
BCS1L -6311
HSPA9 -5919
LETM1 -4667
LYRM7 -2496
NFS1 -2128


Phosphate bond hydrolysis by NUDT proteins
set Phosphate bond hydrolysis by NUDT proteins
setSize 7
pANOVA 0.000594
s.dist -0.749
p.adjustANOVA 0.00297


Top enriched genes
Top 20 genes
GeneID Gene Rank
NUDT16 -10284
ADPRM -9914
NUDT1 -9396
NUDT15 -8717
NUDT5 -7241
NUDT18 -6891
NUDT9 -1842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUDT16 -10284
ADPRM -9914
NUDT1 -9396
NUDT15 -8717
NUDT5 -7241
NUDT18 -6891
NUDT9 -1842


SUMO is conjugated to E1 (UBA2:SAE1)
set SUMO is conjugated to E1 (UBA2:SAE1)
setSize 5
pANOVA 0.00399
s.dist -0.743
p.adjustANOVA 0.0157


Top enriched genes
Top 20 genes
GeneID Gene Rank
SAE1 -10055
SUMO2 -8086
SUMO3 -7807
UBA2 -7336
SUMO1 -5167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SAE1 -10055
SUMO2 -8086
SUMO3 -7807
UBA2 -7336
SUMO1 -5167


Arachidonate production from DAG
set Arachidonate production from DAG
setSize 5
pANOVA 0.0041
s.dist -0.741
p.adjustANOVA 0.016


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABHD6 -10225
ABHD12 -10051
MGLL -9860
DAGLB -6292
DAGLA -1899

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABHD6 -10225
ABHD12 -10051
MGLL -9860
DAGLB -6292
DAGLA -1899


Translation
set Translation
setSize 293
pANOVA 5.08e-104
s.dist -0.732
p.adjustANOVA 9.82e-101


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
EIF3M -10392
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
SEC11A -10174
RPL24 -10169
RPL22L1 -10142
MRPS15 -10133
MRPL51 -10128
RPL4 -10113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MRPL15 -10456
MRPL37 -10432
MRPL3 -10394
EIF3M -10392
MRPS21 -10337
MRPS16 -10323
MRPS28 -10277
EIF4EBP1 -10212
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
SEC11A -10174
RPL24 -10169
RPL22L1 -10142
MRPS15 -10133
MRPL51 -10128
RPL4 -10113
MRPS22 -10101
RPS3A -10096
RPL5 -10094
RPS4X -10092
AIMP2 -10057
RPL36A -10049
MRPS7 -10040
DAP3 -10030
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
SPCS1 -9986
RPL14 -9980
RPL10A -9944
MRPL40 -9939
RPS8 -9928
MRPL17 -9915
EIF3H -9904
RPS24 -9902
MRPL32 -9897
RPL7A -9896
RPL12 -9895
MRPL57 -9894
RPL15 -9886
RPL27 -9880
SSR2 -9870
RPS15A -9864
EIF3E -9856
RPL8 -9829
RPS6 -9825
SSR3 -9815
MRPL34 -9812
RPL34 -9794
RPL23 -9782
MTIF2 -9775
SRPRB -9773
EIF3K -9764
RPL26 -9748
TSFM -9744
RPS23 -9737
MRPL11 -9724
MRPL45 -9715
MRPL12 -9705
EEF1A1 -9700
RPS27 -9690
MRPL48 -9657
KARS1 -9655
RPL32 -9632
RPL11 -9622
MRPL46 -9617
RPL22 -9607
RPL18 -9601
EEF1B2 -9600
MRPL20 -9598
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
CHCHD1 -9555
RPS9 -9546
EIF3I -9539
RPL37A -9538
RPL10 -9523
RPS3 -9514
MRPS27 -9511
UBA52 -9493
MRPS18B -9491
RPL13A -9486
MRPL44 -9484
MRPS18C -9473
RPL31 -9467
PPA1 -9452
MRPL16 -9445
RPL39 -9435
GADD45GIP1 -9421
RPL41 -9415
SSR4 -9403
RPL18A -9381
MRPL52 -9360
SRP14 -9355
EIF4B -9349
RPS11 -9343
DARS1 -9331
EIF3L -9326
RPL35 -9316
MRPL24 -9310
RPLP0 -9307
MRPL36 -9299
RPN1 -9289
MRPL54 -9275
RPS10 -9274
RPL27A -9269
MRPS17 -9267
EIF4A1 -9231
EEF1G -9229
RPN2 -9209
TRMT112 -9206
RPS19 -9142
MRPS11 -9136
RPL23A -9124
MRPL53 -9120
WARS2 -9100
SRP72 -9097
RPS27A -9093
SEC11C -9092
EIF3D -9077
EIF2B2 -9053
DDOST -9051
MRPS35 -9047
MRPL58 -9021
MRPS5 -9020
MTIF3 -8994
MRPL27 -8987
FAU -8965
EIF3G -8962
EEF1E1 -8916
OXA1L -8898
EIF3J -8886
MRPL9 -8852
RPL3 -8849
SRP9 -8846
EEF1A1P5 -8839
EIF2B1 -8805
RPS15 -8796
RPL26L1 -8789
EIF2S3 -8788
MRPS26 -8776
RARS2 -8753
MRPL18 -8752
RPS27L -8746
EIF4H -8741
MRRF -8706
AIMP1 -8672
RPS17 -8643
MRPS23 -8642
TUFM -8625
MRPL49 -8603
PTCD3 -8573
RPL38 -8566
MRPL4 -8532
EIF5 -8531
FARSA -8521
MRPL14 -8517
MRPL47 -8493
SEC61G -8480
MRPS24 -8476
MRPS18A -8450
RPL39L -8440
MRPS2 -8400
RPS5 -8387
MRPL23 -8376
EIF3B -8354
RPS18 -8329
RPS12 -8239
APEH -8186
MTFMT -8157
RPL37 -8134
SEC61A1 -8133
MRPL21 -8109
RPS14 -8103
MRPL55 -8075
EIF2S2 -8035
SEC61B -8033
MRPS14 -8020
SARS2 -7979
ERAL1 -7967
FARSB -7921
RARS1 -7901
RPS2 -7850
MRPS34 -7831
MRPL13 -7769
QARS1 -7692
PPA2 -7623
MRPL43 -7618
EEF1D -7498
RPL36 -7435
MRPL22 -7418
RPL28 -7373
FARS2 -7372
MRPL33 -7354
RPL13 -7350
MRPS9 -7312
MRPS30 -7284
NARS1 -7269
TRAM1 -7258
SRP68 -7246
RPLP2 -7226
EEF2 -7220
MRPL10 -7219
EIF3C -7214
RPS29 -7205
YARS2 -7184
AURKAIP1 -7164
RPS4Y1 -7140
RPLP1 -7065
SPCS2 -7056
MRPL38 -7021
MRPS33 -7001
SARS1 -6944
TARS2 -6895
MRPL1 -6880
RPS21 -6830
EIF3A -6825
MRPS36 -6782
MRPL19 -6743
EIF3F -6730
RPS28 -6699
RPL36AL -6619
MARS2 -6555
RPS16 -6449
EIF1AX -6420
MRPS25 -6380
IARS2 -6296
MRPL28 -6206
MRPL30 -6130
MRPS10 -6117
HARS1 -6057
EIF2B3 -6024
MRPL39 -5938
EPRS1 -5844
GARS1 -5761
MRPS31 -5590
MRPL35 -5552
MRPL2 -5522
EARS2 -5511
EIF2B4 -5452
EIF4A2 -5246
VARS1 -5122
MRPL41 -5086
EIF4E -5067
EIF2S1 -4353
VARS2 -4298
SRP19 -4245
EIF5B -4212
MRPL42 -3938
DARS2 -3606
LARS1 -3520
CARS1 -3181
EIF2B5 -3131
SPCS3 -3044
GSPT1 -2718
ETF1 -2338
GSPT2 -1663
MRPL50 -1530
PARS2 -1331
SSR1 -1072
SRP54 -997
AARS1 -396
HARS2 -371
NARS2 -267
RPL9 -211
GFM2 -152
TARS1 -115
EEF1A2 -106
RPL3L 555
EIF4G1 781
YARS1 839
AARS2 1660
SRPRA 2034
IARS1 2870
MRPS6 3567
MARS1 3600
GFM1 4522
SEC61A2 4644
MTRF1L 5120
N6AMT1 5290
LARS2 5586
RPS26 7854
CARS2 8489
WARS1 9450


SARS-CoV-2 modulates host translation machinery
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 8.67e-19
s.dist -0.73
p.adjustANOVA 3.16e-17


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
RPS24 -9902
RPS15A -9864
RPS6 -9825
SNRPE -9819
SNRPD1 -9792
RPS23 -9737
RPS27 -9690
RPSA -9568
RPS9 -9546
RPS3 -9514
RPS11 -9343
RPS10 -9274
RPS19 -9142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPS3A -10096
RPS4X -10092
RPS20 -10025
RPS25 -10003
RPS8 -9928
RPS24 -9902
RPS15A -9864
RPS6 -9825
SNRPE -9819
SNRPD1 -9792
RPS23 -9737
RPS27 -9690
RPSA -9568
RPS9 -9546
RPS3 -9514
RPS11 -9343
RPS10 -9274
RPS19 -9142
RPS27A -9093
FAU -8965
SNRPB -8906
RPS15 -8796
RPS27L -8746
RPS17 -8643
SNRPD2 -8505
GEMIN6 -8392
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPS14 -8103
RPS2 -7850
SNRPG -7578
RPS29 -7205
RPS4Y1 -7140
RPS21 -6830
RPS28 -6699
RPS16 -6449
SNRPD3 -5163
SNRPF -5085
GEMIN4 -4811
DDX20 -4043
SMN1 -3915
GEMIN2 -3761
GEMIN5 -2453
GEMIN7 -2040
GEMIN8 2952
RPS26 7854


FASTK family proteins regulate processing and stability of mitochondrial RNAs
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 19
pANOVA 4.07e-08
s.dist -0.727
p.adjustANOVA 4.34e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MT-ND2 -10255
MT-ND3 -10179
MT-ND1 -10176
MT-CO2 -9587
MT-CO3 -9085
MT-ATP6 -8914
MT-ND4L -8462
MT-CYB -7734
TBRG4 -7523
MT-ND4 -7515
MT-CO1 -7201
FASTKD2 -6873
MT-ND5 -6747
MT-ATP8 -5197
FASTK -3800
FASTKD5 -2928
MT-ND6 633

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MT-ND2 -10255
MT-ND3 -10179
MT-ND1 -10176
MT-CO2 -9587
MT-CO3 -9085
MT-ATP6 -8914
MT-ND4L -8462
MT-CYB -7734
TBRG4 -7523
MT-ND4 -7515
MT-CO1 -7201
FASTKD2 -6873
MT-ND5 -6747
MT-ATP8 -5197
FASTK -3800
FASTKD5 -2928
MT-ND6 633


Selenoamino acid metabolism
set Selenoamino acid metabolism
setSize 115
pANOVA 5.91e-40
s.dist -0.713
p.adjustANOVA 4.39e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
AHCY -10272
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
AIMP2 -10057
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AHCY -10272
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
AIMP2 -10057
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
NNMT -9723
RPS27 -9690
KARS1 -9655
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
PAPSS1 -9424
RPL41 -9415
RPL18A -9381
RPS11 -9343
DARS1 -9331
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
FAU -8965
EEF1E1 -8916
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
AIMP1 -8672
RPS17 -8643
RPL38 -8566
EEFSEC -8495
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
GSR -8212
RPL37 -8134
RPS14 -8103
RARS1 -7901
RPS2 -7850
QARS1 -7692
RPL36 -7435
RPL28 -7373
RPL13 -7350
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
SARS1 -6944
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
EPRS1 -5844
PAPSS2 -5397
LARS1 -3520
SECISBP2 -1782
CBS -1773
HNMT -702
RPL9 -211
PSTK -117
RPL3L 555
SEPHS2 1630
TXNRD1 2132
SEPSECS 2235
IARS1 2870
MARS1 3600
INMT 6678
RPS26 7854
GNMT 8128
CTH 8315
SCLY 10450


Post-transcriptional silencing by small RNAs
set Post-transcriptional silencing by small RNAs
setSize 7
pANOVA 0.00111
s.dist 0.712
p.adjustANOVA 0.00526


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6C 11322
TNRC6B 10292
AGO1 10039
AGO4 8888
AGO2 7011
TNRC6A 6069
AGO3 4582

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6C 11322
TNRC6B 10292
AGO1 10039
AGO4 8888
AGO2 7011
TNRC6A 6069
AGO3 4582


Cristae formation
set Cristae formation
setSize 33
pANOVA 2.45e-12
s.dist -0.704
p.adjustANOVA 5.14e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5MK -10380
ATP5MG -10105
ATP5F1C -10017
ATP5F1E -10002
ATP5MC1 -9957
ATP5PO -9871
CHCHD3 -9781
ATP5PB -9735
ATP5PD -9684
ATP5PF -9668
ATP5F1A -9449
ATP5F1B -9413
TMEM11 -9362
ATP5MC2 -9311
MT-ATP6 -8914
MICOS10 -8876
ATP5MF -8779
ATP5MJ -8413
MICOS13 -8127
ATP5MC3 -8106

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MK -10380
ATP5MG -10105
ATP5F1C -10017
ATP5F1E -10002
ATP5MC1 -9957
ATP5PO -9871
CHCHD3 -9781
ATP5PB -9735
ATP5PD -9684
ATP5PF -9668
ATP5F1A -9449
ATP5F1B -9413
TMEM11 -9362
ATP5MC2 -9311
MT-ATP6 -8914
MICOS10 -8876
ATP5MF -8779
ATP5MJ -8413
MICOS13 -8127
ATP5MC3 -8106
DMAC2L -8048
ATP5F1D -7280
IMMT -7117
HSPA9 -5919
ATP5ME -5434
MT-ATP8 -5197
DNAJC11 -5158
MTX2 -4778
SAMM50 -3339
CHCHD6 -3257
APOOL -2017
APOO 913
MTX1 5339


Mitochondrial calcium ion transport
set Mitochondrial calcium ion transport
setSize 22
pANOVA 1.31e-08
s.dist -0.7
p.adjustANOVA 1.49e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
VDAC3 -10367
SLC8A3 -10257
AFG3L2 -10173
VDAC1 -9999
PHB -9743
AKAP1 -9603
VDAC2 -9593
STOML2 -9552
MCUB -9442
PHB2 -9439
PARL -8418
PMPCB -7760
MICU3 -7478
MCU -7154
MICU1 -6623
SMDT1 -6383
PMPCA -5261
MICU2 -4704
LETM1 -4667
YME1L1 -3664

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VDAC3 -10367
SLC8A3 -10257
AFG3L2 -10173
VDAC1 -9999
PHB -9743
AKAP1 -9603
VDAC2 -9593
STOML2 -9552
MCUB -9442
PHB2 -9439
PARL -8418
PMPCB -7760
MICU3 -7478
MCU -7154
MICU1 -6623
SMDT1 -6383
PMPCA -5261
MICU2 -4704
LETM1 -4667
YME1L1 -3664
SLC8B1 856
SPG7 927


Packaging Of Telomere Ends
set Packaging Of Telomere Ends
setSize 18
pANOVA 2.9e-07
s.dist -0.698
p.adjustANOVA 2.68e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC6 -10475
H2BC21 -10433
H2BC11 -10260
H2BC12 -10075
H2BC4 -9770
H2AJ -9644
H2BC5 -9559
H2BC17 -9549
H2BC9 -9292
H2AC20 -9251
H2BC15 -8044
H2AZ2 -7006
ACD -4589
TINF2 -4189
TERF1 -4045
TERF2IP -1377
TERF2 -953
POT1 -872

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 -10475
H2BC21 -10433
H2BC11 -10260
H2BC12 -10075
H2BC4 -9770
H2AJ -9644
H2BC5 -9559
H2BC17 -9549
H2BC9 -9292
H2AC20 -9251
H2BC15 -8044
H2AZ2 -7006
ACD -4589
TINF2 -4189
TERF1 -4045
TERF2IP -1377
TERF2 -953
POT1 -872


SUMO is transferred from E1 to E2 (UBE2I, UBC9)
set SUMO is transferred from E1 to E2 (UBE2I, UBC9)
setSize 7
pANOVA 0.00143
s.dist -0.696
p.adjustANOVA 0.00645


Top enriched genes
Top 20 genes
GeneID Gene Rank
SAE1 -10055
SUMO2 -8086
SUMO3 -7807
UBA2 -7336
UBE2I -6569
SUMO1 -5167
RWDD3 -5147

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SAE1 -10055
SUMO2 -8086
SUMO3 -7807
UBA2 -7336
UBE2I -6569
SUMO1 -5167
RWDD3 -5147


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 3.99e-37
s.dist -0.689
p.adjustANOVA 2.41e-35


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
MAGOH -9019
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RNPS1 -8457
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
NCBP2 -7940
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
MAGOHB -7344
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
PPP2R1A -6961
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
PPP2CA -5310
PNRC2 -5014
UPF3A -4900
EIF4A3 -4775
RBM8A -4496
GSPT1 -2718
SMG9 -2458
ETF1 -2338
UPF3B -2309
UPF1 -2230
NCBP1 -1910
DCP1A -1864
SMG8 -1778
GSPT2 -1663
PPP2R2A -1501
RPL9 -211
RPL3L 555
EIF4G1 781
SMG5 3341
UPF2 4618
SMG1 7327
RPS26 7854
SMG6 8139
CASC3 8770
SMG7 10167


Nonsense-Mediated Decay (NMD)
set Nonsense-Mediated Decay (NMD)
setSize 114
pANOVA 3.99e-37
s.dist -0.689
p.adjustANOVA 2.41e-35


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
MAGOH -9019
FAU -8965
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
RPS27L -8746
RPS17 -8643
RPL38 -8566
RNPS1 -8457
RPL39L -8440
RPS5 -8387
RPS18 -8329
RPS12 -8239
RPL37 -8134
RPS14 -8103
NCBP2 -7940
RPS2 -7850
RPL36 -7435
RPL28 -7373
RPL13 -7350
MAGOHB -7344
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
PPP2R1A -6961
RPS21 -6830
RPS28 -6699
RPL36AL -6619
RPS16 -6449
PPP2CA -5310
PNRC2 -5014
UPF3A -4900
EIF4A3 -4775
RBM8A -4496
GSPT1 -2718
SMG9 -2458
ETF1 -2338
UPF3B -2309
UPF1 -2230
NCBP1 -1910
DCP1A -1864
SMG8 -1778
GSPT2 -1663
PPP2R2A -1501
RPL9 -211
RPL3L 555
EIF4G1 781
SMG5 3341
UPF2 4618
SMG1 7327
RPS26 7854
SMG6 8139
CASC3 8770
SMG7 10167


Beta oxidation of hexanoyl-CoA to butanoyl-CoA
set Beta oxidation of hexanoyl-CoA to butanoyl-CoA
setSize 5
pANOVA 0.00805
s.dist -0.684
p.adjustANOVA 0.0287


Top enriched genes
Top 20 genes
GeneID Gene Rank
ECHS1 -9130
ACADS -8640
HADHA -8242
HADH -4979
HADHB -4203

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ECHS1 -9130
ACADS -8640
HADHA -8242
HADH -4979
HADHB -4203


Mitochondrial RNA degradation
set Mitochondrial RNA degradation
setSize 25
pANOVA 3.17e-09
s.dist -0.684
p.adjustANOVA 4.06e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MT-ND2 -10255
MT-ND3 -10179
MT-ND1 -10176
SLIRP -9948
MT-CO2 -9587
GRSF1 -9526
MT-CO3 -9085
MT-ATP6 -8914
MT-ND4L -8462
MT-CYB -7734
TBRG4 -7523
MT-ND4 -7515
MT-CO1 -7201
FASTKD2 -6873
PNPT1 -6800
MT-ND5 -6747
LRPPRC -6121
MT-ATP8 -5197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MT-ND2 -10255
MT-ND3 -10179
MT-ND1 -10176
SLIRP -9948
MT-CO2 -9587
GRSF1 -9526
MT-CO3 -9085
MT-ATP6 -8914
MT-ND4L -8462
MT-CYB -7734
TBRG4 -7523
MT-ND4 -7515
MT-CO1 -7201
FASTKD2 -6873
PNPT1 -6800
MT-ND5 -6747
LRPPRC -6121
MT-ATP8 -5197
SUPV3L1 -4503
FASTK -3800
FASTKD5 -2928
MT-ND6 633
REXO2 3731


rRNA processing in the mitochondrion
set rRNA processing in the mitochondrion
setSize 24
pANOVA 7.81e-09
s.dist -0.68
p.adjustANOVA 9.38e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MT-ND2 -10255
MT-ND3 -10179
MT-ND1 -10176
MRM2 -10099
MT-CO2 -9587
MT-CO3 -9085
MT-ATP6 -8914
MRM3 -8488
MT-ND4L -8462
HSD17B10 -7812
MT-CYB -7734
MT-ND4 -7515
MT-CO1 -7201
TRMT10C -7181
MT-ND5 -6747
MRM1 -6593
ELAC2 -6479
PRORP -6415

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
MT-ND2 -10255
MT-ND3 -10179
MT-ND1 -10176
MRM2 -10099
MT-CO2 -9587
MT-CO3 -9085
MT-ATP6 -8914
MRM3 -8488
MT-ND4L -8462
HSD17B10 -7812
MT-CYB -7734
MT-ND4 -7515
MT-CO1 -7201
TRMT10C -7181
MT-ND5 -6747
MRM1 -6593
ELAC2 -6479
PRORP -6415
MT-ATP8 -5197
NSUN4 -3182
TFB1M 2011
MTERF4 8547


Processing of SMDT1
set Processing of SMDT1
setSize 15
pANOVA 5.06e-06
s.dist -0.68
p.adjustANOVA 3.92e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
AFG3L2 -10173
PHB -9743
STOML2 -9552
MCUB -9442
PHB2 -9439
PARL -8418
PMPCB -7760
MICU3 -7478
MCU -7154
MICU1 -6623
SMDT1 -6383
PMPCA -5261
MICU2 -4704
YME1L1 -3664
SPG7 927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AFG3L2 -10173
PHB -9743
STOML2 -9552
MCUB -9442
PHB2 -9439
PARL -8418
PMPCB -7760
MICU3 -7478
MCU -7154
MICU1 -6623
SMDT1 -6383
PMPCA -5261
MICU2 -4704
YME1L1 -3664
SPG7 927


RNA Polymerase I Promoter Opening
set RNA Polymerase I Promoter Opening
setSize 17
pANOVA 1.39e-06
s.dist -0.676
p.adjustANOVA 1.16e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC6 -10475.0
H2BC21 -10433.0
H2BC11 -10260.0
H2BC12 -10075.0
H2BC4 -9770.0
H2AJ -9644.0
H2BC5 -9559.0
H2BC17 -9549.0
H2BC9 -9292.0
H2AC20 -9251.0
H2BC15 -8044.0
H3-3A -7627.0
H2AZ2 -7006.0
MBD2 -6465.0
MAPK3 -2454.0
H3C15 5170.5
UBTF 6711.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 -10475.0
H2BC21 -10433.0
H2BC11 -10260.0
H2BC12 -10075.0
H2BC4 -9770.0
H2AJ -9644.0
H2BC5 -9559.0
H2BC17 -9549.0
H2BC9 -9292.0
H2AC20 -9251.0
H2BC15 -8044.0
H3-3A -7627.0
H2AZ2 -7006.0
MBD2 -6465.0
MAPK3 -2454.0
H3C15 5170.5
UBTF 6711.0


Major pathway of rRNA processing in the nucleolus and cytosol
set Major pathway of rRNA processing in the nucleolus and cytosol
setSize 179
pANOVA 6.87e-55
s.dist -0.674
p.adjustANOVA 1.9e-52


Top enriched genes
Top 20 genes
GeneID Gene Rank
EXOSC2 -10343
UTP4 -10296
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
EXOSC1 -10015
RPS25 -10003
RPL6 -10001
UTP14A -10000
RPL21 -9993

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC2 -10343
UTP4 -10296
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
EXOSC1 -10015
RPS25 -10003
RPL6 -10001
UTP14A -10000
RPL21 -9993
RPL14 -9980
UTP18 -9946
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
WDR46 -9885
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
EBNA1BP2 -9803
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
NOB1 -9540
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPP40 -9487
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
EXOSC5 -9387
RPL18A -9381
UTP11 -9363
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
EXOSC8 -9199
EXOSC7 -9172
RPS19 -9142
RPL23A -9124
WDR12 -9117
NOP56 -9094
RPS27A -9093
RRP36 -9066
UTP6 -8979
PES1 -8972
FAU -8965
RIOK1 -8947
GNL3 -8868
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
IMP3 -8763
RPS27L -8746
WDR43 -8714
SNU13 -8650
RPS17 -8643
FBL -8639
IMP4 -8589
RPL38 -8566
TSR1 -8553
DDX49 -8539
RPL39L -8440
RPS5 -8387
EMG1 -8382
RPS18 -8329
RPS12 -8239
RPL37 -8134
WDR75 -8120
RPS14 -8103
DDX47 -7882
RPP21 -7871
RPS2 -7850
RRP9 -7765
NOP14 -7664
RPL36 -7435
RPL28 -7373
RPL13 -7350
LTV1 -7338
MPHOSPH6 -7299
NOC4L -7264
EXOSC9 -7255
RPLP2 -7226
NOL12 -7218
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RRP7A -6940
XRN2 -6915
RPS21 -6830
DDX21 -6810
BMS1 -6774
PNO1 -6725
WDR18 -6704
RPS28 -6699
RPL36AL -6619
MPHOSPH10 -6572
NCL -6538
C1D -6484
DCAF13 -6476
RPS16 -6449
NOP58 -6437
NOL11 -6417
BOP1 -6262
TBL3 -6242
RIOK3 -6151
NOL6 -6079
RPP38 -5909
LAS1L -5661
RRP1 -5483
RPP25 -4964
NIP7 -4950
ISG20L2 -4937
UTP3 -4485
WDR3 -4088
RPP30 -3703
DHX37 -3595
WDR36 -3272
EXOSC3 -2759
EXOSC4 -2745
TEX10 -2664
SENP3 -2653
FCF1 -2310
FTSJ3 -2290
RBM28 -1956
UTP14C -1089
NOL9 -940
KRR1 -565
EXOSC6 -557
RPP14 -483
RCL1 -422
UTP15 -279
RPL9 -211
PDCD11 163
RIOK2 435
RPL3L 555
CSNK1E 758
ERI1 840
PWP2 1454
BYSL 1501
UTP25 1623
DIS3 2248
EXOSC10 3111
CSNK1D 3284
PELP1 3311
DDX52 3392
UTP20 4482
HEATR1 7471
RPS26 7854


rRNA processing
set rRNA processing
setSize 213
pANOVA 5.14e-64
s.dist -0.669
p.adjustANOVA 2.48e-61


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
EXOSC2 -10343
UTP4 -10296
MT-ND2 -10255
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
MT-ND3 -10179
MT-ND1 -10176
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
MRM2 -10099
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10513
MT-RNR2 -10512
EXOSC2 -10343
UTP4 -10296
MT-ND2 -10255
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
MT-ND3 -10179
MT-ND1 -10176
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
MRM2 -10099
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
EXOSC1 -10015
RPS25 -10003
RPL6 -10001
UTP14A -10000
RPL21 -9993
RPL14 -9980
UTP18 -9946
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
WDR46 -9885
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
EBNA1BP2 -9803
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
MT-CO2 -9587
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
NOB1 -9540
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPP40 -9487
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
EXOSC5 -9387
RPL18A -9381
UTP11 -9363
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
TRMT112 -9206
EXOSC8 -9199
EXOSC7 -9172
RPS19 -9142
NHP2 -9132
RPL23A -9124
WDR12 -9117
NOP56 -9094
RPS27A -9093
MT-CO3 -9085
RRP36 -9066
UTP6 -8979
PES1 -8972
FAU -8965
RIOK1 -8947
MT-ATP6 -8914
GNL3 -8868
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
IMP3 -8763
RPS27L -8746
WDR43 -8714
SNU13 -8650
RPS17 -8643
FBL -8639
IMP4 -8589
RPL38 -8566
TSR1 -8553
DDX49 -8539
MRM3 -8488
MT-ND4L -8462
RPL39L -8440
RPS5 -8387
EMG1 -8382
RPS18 -8329
RPS12 -8239
RPL37 -8134
WDR75 -8120
RPS14 -8103
TSR3 -7954
DDX47 -7882
RPP21 -7871
RPS2 -7850
HSD17B10 -7812
RRP9 -7765
MT-CYB -7734
NOP14 -7664
MT-ND4 -7515
RPL36 -7435
RPL28 -7373
RPL13 -7350
LTV1 -7338
MPHOSPH6 -7299
NOC4L -7264
EXOSC9 -7255
RPLP2 -7226
NOL12 -7218
RPS29 -7205
MT-CO1 -7201
TRMT10C -7181
RPS4Y1 -7140
RPLP1 -7065
RRP7A -6940
XRN2 -6915
RPS21 -6830
DDX21 -6810
BMS1 -6774
DIMT1 -6760
MT-ND5 -6747
PNO1 -6725
WDR18 -6704
RPS28 -6699
RPL36AL -6619
MRM1 -6593
MPHOSPH10 -6572
NCL -6538
NOP10 -6491
C1D -6484
ELAC2 -6479
DCAF13 -6476
RPS16 -6449
NOP58 -6437
NOL11 -6417
PRORP -6415
BOP1 -6262
TBL3 -6242
RIOK3 -6151
NOL6 -6079
RPP38 -5909
LAS1L -5661
RRP1 -5483
MT-ATP8 -5197
DKC1 -5029
RPP25 -4964
NIP7 -4950
ISG20L2 -4937
UTP3 -4485
WDR3 -4088
RPP30 -3703
DHX37 -3595
NOP2 -3525
NAT10 -3475
WDR36 -3272
NSUN4 -3182
EXOSC3 -2759
EXOSC4 -2745
TEX10 -2664
SENP3 -2653
FCF1 -2310
FTSJ3 -2290
RBM28 -1956
UTP14C -1089
NOL9 -940
GAR1 -651
KRR1 -565
EXOSC6 -557
RPP14 -483
RCL1 -422
UTP15 -279
RPL9 -211
PDCD11 163
THUMPD1 233
RIOK2 435
RPL3L 555
CSNK1E 758
ERI1 840
PWP2 1454
BYSL 1501
UTP25 1623
TFB1M 2011
DIS3 2248
EXOSC10 3111
CSNK1D 3284
PELP1 3311
DDX52 3392
UTP20 4482
HEATR1 7471
RPS26 7854
MTERF4 8547


Regulation of expression of SLITs and ROBOs
set Regulation of expression of SLITs and ROBOs
setSize 149
pANOVA 3.08e-45
s.dist -0.668
p.adjustANOVA 3.96e-43


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBX1 -10487
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBX1 -10487
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
RPS25 -10003
RPL6 -10001
RPL21 -9993
RPL14 -9980
RPL10A -9944
RPS8 -9928
UBC -9922
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
RPL27 -9880
RPS15A -9864
PSMA6 -9853
RPL8 -9829
RPS6 -9825
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
PSMB1 -9652
PSMD8 -9645
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
PABPC1 -9588
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
RPL18A -9381
RPS11 -9343
RPL35 -9316
RPLP0 -9307
PSMB4 -9305
PSMA5 -9284
RPS10 -9274
RPL27A -9269
RPS19 -9142
RPL23A -9124
RPS27A -9093
MAGOH -9019
FAU -8965
PSMC3 -8851
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
PSMA2 -8772
PSMC2 -8762
RPS27L -8746
PSMB5 -8725
PSMC1 -8704
RPS17 -8643
RPL38 -8566
PSMB2 -8540
RNPS1 -8457
RPL39L -8440
RPS5 -8387
RPS18 -8329
PSMD7 -8323
PSMD13 -8296
PSMA7 -8270
RPS12 -8239
ELOC -8221
PSMB6 -8169
RPL37 -8134
RPS14 -8103
NCBP2 -7940
PSMB7 -7911
RPS2 -7850
PSMD14 -7790
PSMA1 -7755
RPL36 -7435
PSMC4 -7380
RPL28 -7373
RPL13 -7350
MAGOHB -7344
RPLP2 -7226
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
PSMC5 -6973
ELOB -6850
RPS21 -6830
PSMA4 -6764
PSMB3 -6724
RPS28 -6699
RPL36AL -6619
RPS16 -6449
ADRM1 -5643
UBB -5642
UPF3A -4900
PSMC6 -4863
EIF4A3 -4775
SEM1 -4691
RBM8A -4496
CUL2 -4044
PSMA3 -4017
PSMD3 -3864
PSMD2 -3071
GSPT1 -2718
ETF1 -2338
UPF3B -2309
NCBP1 -1910
DAG1 -1821
GSPT2 -1663
RPL9 -211
PSMD12 -126
RPL3L 555
EIF4G1 781
PSMD1 1165
USP33 2345
ROBO3 3128
LHX4 3302
PSMD11 3925
LDB1 4181
SLIT1 4334
UPF2 4618
COL4A5 5732
ROBO1 6241
PSMD6 6480
ZSWIM8 7132
RPS26 7854
CASC3 8770


Complex I biogenesis
set Complex I biogenesis
setSize 66
pANOVA 5.8e-21
s.dist -0.668
p.adjustANOVA 2.33e-19


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFA6 -10399.0
MT-ND2 -10255.0
MT-ND3 -10179.0
MT-ND1 -10176.0
NDUFAF3 -10106.0
NDUFS4 -10100.0
HSCB -10020.0
NDUFB9 -9620.0
ECSIT -9574.0
NDUFA12 -9504.0
PYURF -9374.5
NDUFA10 -9280.0
TIMMDC1 -9244.0
NDUFC2 -9178.0
NDUFB11 -9108.0
NDUFAB1 -9090.0
NDUFV2 -9069.0
OXA1L -8898.0
NDUFB2 -8890.0
NDUFB5 -8865.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA6 -10399.0
MT-ND2 -10255.0
MT-ND3 -10179.0
MT-ND1 -10176.0
NDUFAF3 -10106.0
NDUFS4 -10100.0
HSCB -10020.0
NDUFB9 -9620.0
ECSIT -9574.0
NDUFA12 -9504.0
PYURF -9374.5
NDUFA10 -9280.0
TIMMDC1 -9244.0
NDUFC2 -9178.0
NDUFB11 -9108.0
NDUFAB1 -9090.0
NDUFV2 -9069.0
OXA1L -8898.0
NDUFB2 -8890.0
NDUFB5 -8865.0
NDUFA1 -8824.0
NDUFB4 -8747.0
NDUFB1 -8737.0
NDUFA8 -8605.0
NDUFB7 -8567.0
TMEM126A -8518.0
NDUFB6 -8498.0
NDUFA3 -8349.0
NDUFC1 -8185.0
NDUFB8 -7761.0
LYRM2 -7722.0
NDUFAF8 -7678.0
NDUFS5 -7647.0
NDUFA2 -7561.0
MT-ND4 -7515.0
NDUFB10 -7421.0
TMEM126B -7391.0
NDUFS3 -7276.0
NDUFA13 -7049.0
NDUFS8 -7024.0
NDUFS6 -6916.0
NDUFAF4 -6901.0
MT-ND5 -6747.0
NDUFA5 -6500.0
TMEM186 -6439.0
NDUFB3 -6425.0
NDUFV1 -6010.0
HSPA9 -5919.0
NDUFS7 -5881.0
NDUFS2 -5785.0
NDUFAF5 -5756.0
NDUFA9 -5505.0
NDUFA7 -5406.0
NDUFAF2 -5405.0
ACAD9 -4675.0
NDUFV3 -4040.0
NDUFA11 -3443.0
COA1 -2149.0
SFXN4 -2059.0
NDUFAF6 -1829.0
NDUFS1 -1666.0
NDUFAF7 -1125.0
FOXRED1 426.0
MT-ND6 633.0
NUBPL 1889.0
NDUFAF1 2263.0


rRNA processing in the nucleus and cytosol
set rRNA processing in the nucleus and cytosol
setSize 189
pANOVA 1.5e-56
s.dist -0.666
p.adjustANOVA 5.8e-54


Top enriched genes
Top 20 genes
GeneID Gene Rank
EXOSC2 -10343
UTP4 -10296
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
EXOSC1 -10015
RPS25 -10003
RPL6 -10001
UTP14A -10000
RPL21 -9993

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC2 -10343
UTP4 -10296
RPS13 -10206
RPS7 -10200
RPL7 -10191
RPL35A -10182
RPL24 -10169
RPL22L1 -10142
RPL4 -10113
RPS3A -10096
RPL5 -10094
RPS4X -10092
RPL36A -10049
RPS20 -10025
RPL29 -10019
EXOSC1 -10015
RPS25 -10003
RPL6 -10001
UTP14A -10000
RPL21 -9993
RPL14 -9980
UTP18 -9946
RPL10A -9944
RPS8 -9928
RPS24 -9902
RPL7A -9896
RPL12 -9895
RPL15 -9886
WDR46 -9885
RPL27 -9880
RPS15A -9864
RPL8 -9829
RPS6 -9825
EBNA1BP2 -9803
RPL34 -9794
RPL23 -9782
RPL26 -9748
RPS23 -9737
RPS27 -9690
RPL32 -9632
RPL11 -9622
RPL22 -9607
RPL18 -9601
RPL19 -9595
RPL17 -9570
RPSA -9568
RPL30 -9556
RPS9 -9546
NOB1 -9540
RPL37A -9538
RPL10 -9523
RPS3 -9514
UBA52 -9493
RPP40 -9487
RPL13A -9486
RPL31 -9467
RPL39 -9435
RPL41 -9415
EXOSC5 -9387
RPL18A -9381
UTP11 -9363
RPS11 -9343
RPL35 -9316
RPLP0 -9307
RPS10 -9274
RPL27A -9269
TRMT112 -9206
EXOSC8 -9199
EXOSC7 -9172
RPS19 -9142
NHP2 -9132
RPL23A -9124
WDR12 -9117
NOP56 -9094
RPS27A -9093
RRP36 -9066
UTP6 -8979
PES1 -8972
FAU -8965
RIOK1 -8947
GNL3 -8868
RPL3 -8849
RPS15 -8796
RPL26L1 -8789
IMP3 -8763
RPS27L -8746
WDR43 -8714
SNU13 -8650
RPS17 -8643
FBL -8639
IMP4 -8589
RPL38 -8566
TSR1 -8553
DDX49 -8539
RPL39L -8440
RPS5 -8387
EMG1 -8382
RPS18 -8329
RPS12 -8239
RPL37 -8134
WDR75 -8120
RPS14 -8103
TSR3 -7954
DDX47 -7882
RPP21 -7871
RPS2 -7850
RRP9 -7765
NOP14 -7664
RPL36 -7435
RPL28 -7373
RPL13 -7350
LTV1 -7338
MPHOSPH6 -7299
NOC4L -7264
EXOSC9 -7255
RPLP2 -7226
NOL12 -7218
RPS29 -7205
RPS4Y1 -7140
RPLP1 -7065
RRP7A -6940
XRN2 -6915
RPS21 -6830
DDX21 -6810
BMS1 -6774
DIMT1 -6760
PNO1 -6725
WDR18 -6704
RPS28 -6699
RPL36AL -6619
MPHOSPH10 -6572
NCL -6538
NOP10 -6491
C1D -6484
DCAF13 -6476
RPS16 -6449
NOP58 -6437
NOL11 -6417
BOP1 -6262
TBL3 -6242
RIOK3 -6151
NOL6 -6079
RPP38 -5909
LAS1L -5661
RRP1 -5483
DKC1 -5029
RPP25 -4964
NIP7 -4950
ISG20L2 -4937
UTP3 -4485
WDR3 -4088
RPP30 -3703
DHX37 -3595
NOP2 -3525
NAT10 -3475
WDR36 -3272
EXOSC3 -2759
EXOSC4 -2745
TEX10 -2664
SENP3 -2653
FCF1 -2310
FTSJ3 -2290
RBM28 -1956
UTP14C -1089
NOL9 -940
GAR1 -651
KRR1 -565
EXOSC6 -557
RPP14 -483
RCL1 -422
UTP15 -279
RPL9 -211
PDCD11 163
THUMPD1 233
RIOK2 435
RPL3L 555
CSNK1E 758
ERI1 840
PWP2 1454
BYSL 1501
UTP25 1623
DIS3 2248
EXOSC10 3111
CSNK1D 3284
PELP1 3311
DDX52 3392
UTP20 4482
HEATR1 7471
RPS26 7854


Cleavage of the damaged purine
set Cleavage of the damaged purine
setSize 22
pANOVA 7.86e-08
s.dist -0.661
p.adjustANOVA 7.83e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC6 -10475
H2BC21 -10433
H2BC11 -10260
H2BC12 -10075
H2BC4 -9770
H2AJ -9644
H2BC5 -9559
H2BC17 -9549
MPG -9453
H2BC9 -9292
H2AC20 -9251
H2BC15 -8044
H2AZ2 -7006
ACD -4589
TINF2 -4189
TERF1 -4045
OGG1 -4027
MUTYH -3643
NEIL3 -2643
TERF2IP -1377

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 -10475
H2BC21 -10433
H2BC11 -10260
H2BC12 -10075
H2BC4 -9770
H2AJ -9644
H2BC5 -9559
H2BC17 -9549
MPG -9453
H2BC9 -9292
H2AC20 -9251
H2BC15 -8044
H2AZ2 -7006
ACD -4589
TINF2 -4189
TERF1 -4045
OGG1 -4027
MUTYH -3643
NEIL3 -2643
TERF2IP -1377
TERF2 -953
POT1 -872


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Adenylate cyclase activating pathway`
## [1] "ADCY4"
## 
## [[1]]$`UP genesets.Bicarbonate transporters`
## [1] "SLC4A1" "SLC4A4" "SLC4A5"
## 
## [[1]]$`UP genesets.Cation-coupled Chloride cotransporters`
## [1] "SLC12A6"
## 
## [[1]]$`UP genesets.Cohesin Loading onto Chromatin`
## character(0)
## 
## [[1]]$`UP genesets.Competing endogenous RNAs (ceRNAs) regulate PTEN translation`
## [1] "TNRC6C"
## 
## [[1]]$`UP genesets.HDMs demethylate histones`
## [1] "KDM2B" "KDM5D" "KDM6B" "PHF8" 
## 
## [[1]]$`UP genesets.Interleukin-15 signaling`
## [1] "IL2RB"
## 
## [[1]]$`UP genesets.Interleukin-21 signaling`
## [1] "IL21R" "STAT4"
## 
## [[1]]$`UP genesets.Post-transcriptional silencing by small RNAs`
## [1] "TNRC6C"
## 
## [[1]]$`UP genesets.RORA activates gene expression`
## [1] "CREBBP" "NCOA2"  "RXRA"   "TBL1X" 
## 
## [[1]]$`UP genesets.Regulation of CDH11 Expression and Function`
## [1] "ADAM19" "TNRC6C"
## 
## [[1]]$`UP genesets.Regulation of CDH11 function`
## [1] "ADAM19"
## 
## [[1]]$`UP genesets.Regulation of CDH11 mRNA translation by microRNAs`
## [1] "TNRC6C"
## 
## [[1]]$`UP genesets.Regulation of Expression and Function of Type II Classical Cadherins`
## [1] "ADAM19"  "TNRC6C"  "ZC3H12A"
## 
## [[1]]$`UP genesets.Regulation of Homotypic Cell-Cell Adhesion`
## [1] "ADAM19"  "TNRC6C"  "ZC3H12A"
## 
## [[1]]$`UP genesets.Regulation of NFE2L2 gene expression`
## [1] "CREBBP" "NFKB1"  "NOTCH1"
## 
## [[1]]$`UP genesets.Regulation of NPAS4 gene expression`
## [1] "TNRC6C"
## 
## [[1]]$`UP genesets.Regulation of NPAS4 mRNA translation`
## [1] "TNRC6C"
## 
## [[1]]$`UP genesets.Signaling by RNF43 mutants`
## [1] "FZD4"
## 
## [[1]]$`UP genesets.TGFBR3 expression`
## [1] "RXRA"   "TCF4"   "TGFBR3" "TNRC6C"
## 
## [[1]]$`DOWN genesets.Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S`
##  [1] "EIF1AX"   "EIF2S1"   "EIF2S2"   "EIF2S3"   "EIF3A"    "EIF3B"   
##  [7] "EIF3C"    "EIF3D"    "EIF3E"    "EIF3F"    "EIF3G"    "EIF3H"   
## [13] "EIF3I"    "EIF3J"    "EIF3K"    "EIF3L"    "EIF3M"    "EIF4A1"  
## [19] "EIF4A2"   "EIF4B"    "EIF4E"    "EIF4EBP1" "EIF4G1"   "EIF4H"   
## [25] "FAU"      "PABPC1"   "RPS10"    "RPS11"    "RPS12"    "RPS13"   
## [31] "RPS14"    "RPS15"    "RPS15A"   "RPS16"    "RPS17"    "RPS18"   
## [37] "RPS19"    "RPS2"     "RPS20"    "RPS21"    "RPS23"    "RPS24"   
## [43] "RPS25"    "RPS26"    "RPS27"    "RPS27A"   "RPS27L"   "RPS28"   
## [49] "RPS29"    "RPS3"     "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"    
## [55] "RPS6"     "RPS7"     "RPS8"     "RPS9"     "RPSA"    
## 
## [[1]]$`DOWN genesets.Cap-dependent Translation Initiation`
##   [1] "EIF1AX"   "EIF2B1"   "EIF2B2"   "EIF2B3"   "EIF2B4"   "EIF2B5"  
##   [7] "EIF2S1"   "EIF2S2"   "EIF2S3"   "EIF3A"    "EIF3B"    "EIF3C"   
##  [13] "EIF3D"    "EIF3E"    "EIF3F"    "EIF3G"    "EIF3H"    "EIF3I"   
##  [19] "EIF3J"    "EIF3K"    "EIF3L"    "EIF3M"    "EIF4A1"   "EIF4A2"  
##  [25] "EIF4B"    "EIF4E"    "EIF4EBP1" "EIF4G1"   "EIF4H"    "EIF5"    
##  [31] "EIF5B"    "FAU"      "PABPC1"   "RPL10"    "RPL10A"   "RPL11"   
##  [37] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
##  [43] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
##  [49] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
##  [55] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
##  [61] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
##  [67] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
##  [73] "RPL3L"    "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"    
##  [79] "RPL7A"    "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"   
##  [85] "RPS10"    "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"   
##  [91] "RPS15A"   "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"    
##  [97] "RPS20"    "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"   
## [103] "RPS27"    "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"    
## [109] "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"    
## [115] "RPS8"     "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Elongation`
##  [1] "EEF1A1"   "EEF1A1P5" "EEF1A2"   "EEF1B2"   "EEF1D"    "EEF1G"   
##  [7] "EEF2"     "FAU"      "RPL10"    "RPL10A"   "RPL11"    "RPL12"   
## [13] "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"    "RPL18"   
## [19] "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1"  "RPL23"   
## [25] "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"    "RPL27A"  
## [31] "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"    "RPL32"   
## [37] "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"   "RPL36AL" 
## [43] "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"   "RPL3L"   
## [49] "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"     "RPL7A"   
## [55] "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"    "RPS10"   
## [61] "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"    "RPS15A"  
## [67] "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"     "RPS20"   
## [73] "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"    "RPS27"   
## [79] "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"     "RPS3A"   
## [85] "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"     "RPS8"    
## [91] "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Initiation`
##   [1] "EIF1AX"   "EIF2B1"   "EIF2B2"   "EIF2B3"   "EIF2B4"   "EIF2B5"  
##   [7] "EIF2S1"   "EIF2S2"   "EIF2S3"   "EIF3A"    "EIF3B"    "EIF3C"   
##  [13] "EIF3D"    "EIF3E"    "EIF3F"    "EIF3G"    "EIF3H"    "EIF3I"   
##  [19] "EIF3J"    "EIF3K"    "EIF3L"    "EIF3M"    "EIF4A1"   "EIF4A2"  
##  [25] "EIF4B"    "EIF4E"    "EIF4EBP1" "EIF4G1"   "EIF4H"    "EIF5"    
##  [31] "EIF5B"    "FAU"      "PABPC1"   "RPL10"    "RPL10A"   "RPL11"   
##  [37] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
##  [43] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
##  [49] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
##  [55] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
##  [61] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
##  [67] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
##  [73] "RPL3L"    "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"    
##  [79] "RPL7A"    "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"   
##  [85] "RPS10"    "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"   
##  [91] "RPS15A"   "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"    
##  [97] "RPS20"    "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"   
## [103] "RPS27"    "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"    
## [109] "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"    
## [115] "RPS8"     "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Termination`
##  [1] "APEH"    "ETF1"    "FAU"     "GSPT1"   "GSPT2"   "N6AMT1"  "RPL10"  
##  [8] "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"  
## [15] "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1"
## [22] "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A" 
## [29] "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"  
## [36] "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A" 
## [43] "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"    "RPL41"   "RPL5"   
## [50] "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"  
## [57] "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"  
## [64] "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"  
## [71] "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A" 
## [78] "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1" 
## [85] "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"    "TRMT112"
## [92] "UBA52"  
## 
## [[1]]$`DOWN genesets.Formation of ATP by chemiosmotic coupling`
##  [1] "ATP5F1A" "ATP5F1B" "ATP5F1C" "ATP5F1D" "ATP5F1E" "ATP5MC1" "ATP5MC2"
##  [8] "ATP5MC3" "ATP5ME"  "ATP5MF"  "ATP5MG"  "ATP5MJ"  "ATP5MK"  "ATP5PB" 
## [15] "ATP5PD"  "ATP5PF"  "ATP5PO"  "DMAC2L"  "MT-ATP6" "MT-ATP8"
## 
## [[1]]$`DOWN genesets.Formation of a pool of free 40S subunits`
##   [1] "EIF1AX"  "EIF3A"   "EIF3B"   "EIF3C"   "EIF3D"   "EIF3E"   "EIF3F"  
##   [8] "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"   "EIF3K"   "EIF3L"   "EIF3M"  
##  [15] "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A" 
##  [22] "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"  
##  [29] "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1"
##  [36] "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"  
##  [43] "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL"
##  [50] "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"   
##  [57] "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"   
##  [64] "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"  
##  [71] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
##  [78] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
##  [85] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
##  [92] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
##  [99] "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Formation of the ternary complex, and subsequently, the 43S complex`
##  [1] "EIF1AX" "EIF2S1" "EIF2S2" "EIF2S3" "EIF3A"  "EIF3B"  "EIF3C"  "EIF3D" 
##  [9] "EIF3E"  "EIF3F"  "EIF3G"  "EIF3H"  "EIF3I"  "EIF3J"  "EIF3K"  "EIF3L" 
## [17] "EIF3M"  "FAU"    "RPS10"  "RPS11"  "RPS12"  "RPS13"  "RPS14"  "RPS15" 
## [25] "RPS15A" "RPS16"  "RPS17"  "RPS18"  "RPS19"  "RPS2"   "RPS20"  "RPS21" 
## [33] "RPS23"  "RPS24"  "RPS25"  "RPS26"  "RPS27"  "RPS27A" "RPS27L" "RPS28" 
## [41] "RPS29"  "RPS3"   "RPS3A"  "RPS4X"  "RPS4Y1" "RPS5"   "RPS6"   "RPS7"  
## [49] "RPS8"   "RPS9"   "RPSA"  
## 
## [[1]]$`DOWN genesets.GTP hydrolysis and joining of the 60S ribosomal subunit`
##   [1] "EIF1AX"  "EIF2S1"  "EIF2S2"  "EIF2S3"  "EIF3A"   "EIF3B"   "EIF3C"  
##   [8] "EIF3D"   "EIF3E"   "EIF3F"   "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"  
##  [15] "EIF3K"   "EIF3L"   "EIF3M"   "EIF4A1"  "EIF4A2"  "EIF4B"   "EIF4E"  
##  [22] "EIF4G1"  "EIF4H"   "EIF5"    "EIF5B"   "FAU"     "RPL10"   "RPL10A" 
##  [29] "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"  
##  [36] "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"  
##  [43] "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"  
##  [50] "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"  
##  [57] "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"  
##  [64] "RPL39"   "RPL39L"  "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"   
##  [71] "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"  
##  [78] "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A" 
##  [85] "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"  
##  [92] "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L" 
##  [99] "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"   
## [106] "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.L13a-mediated translational silencing of Ceruloplasmin expression`
##   [1] "EIF1AX"  "EIF2S1"  "EIF2S2"  "EIF2S3"  "EIF3A"   "EIF3B"   "EIF3C"  
##   [8] "EIF3D"   "EIF3E"   "EIF3F"   "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"  
##  [15] "EIF3K"   "EIF3L"   "EIF3M"   "EIF4A1"  "EIF4A2"  "EIF4B"   "EIF4E"  
##  [22] "EIF4G1"  "EIF4H"   "FAU"     "PABPC1"  "RPL10"   "RPL10A"  "RPL11"  
##  [29] "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"  
##  [36] "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A" 
##  [43] "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"  
##  [50] "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A" 
##  [57] "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"  
##  [64] "RPL39L"  "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"   
##  [71] "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"  
##  [78] "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"  
##  [85] "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"  
##  [92] "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"  
##  [99] "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"   
## [106] "RPS7"    "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Mitochondrial translation elongation`
##  [1] "AURKAIP1"   "CHCHD1"     "DAP3"       "ERAL1"      "GADD45GIP1"
##  [6] "GFM1"       "MRPL1"      "MRPL10"     "MRPL11"     "MRPL12"    
## [11] "MRPL13"     "MRPL14"     "MRPL15"     "MRPL16"     "MRPL17"    
## [16] "MRPL18"     "MRPL19"     "MRPL2"      "MRPL20"     "MRPL21"    
## [21] "MRPL22"     "MRPL23"     "MRPL24"     "MRPL27"     "MRPL28"    
## [26] "MRPL3"      "MRPL30"     "MRPL32"     "MRPL33"     "MRPL34"    
## [31] "MRPL35"     "MRPL36"     "MRPL37"     "MRPL38"     "MRPL39"    
## [36] "MRPL4"      "MRPL40"     "MRPL41"     "MRPL42"     "MRPL43"    
## [41] "MRPL44"     "MRPL45"     "MRPL46"     "MRPL47"     "MRPL48"    
## [46] "MRPL49"     "MRPL50"     "MRPL51"     "MRPL52"     "MRPL53"    
## [51] "MRPL54"     "MRPL55"     "MRPL57"     "MRPL58"     "MRPL9"     
## [56] "MRPS10"     "MRPS11"     "MRPS14"     "MRPS15"     "MRPS16"    
## [61] "MRPS17"     "MRPS18A"    "MRPS18B"    "MRPS18C"    "MRPS2"     
## [66] "MRPS21"     "MRPS22"     "MRPS23"     "MRPS24"     "MRPS25"    
## [71] "MRPS26"     "MRPS27"     "MRPS28"     "MRPS30"     "MRPS31"    
## [76] "MRPS33"     "MRPS34"     "MRPS35"     "MRPS36"     "MRPS5"     
## [81] "MRPS6"      "MRPS7"      "MRPS9"      "MT-RNR1"    "MT-RNR2"   
## [86] "OXA1L"      "PTCD3"      "RPS12"      "TSFM"       "TUFM"      
## 
## [[1]]$`DOWN genesets.Mitochondrial translation initiation`
##  [1] "AURKAIP1"   "CHCHD1"     "DAP3"       "ERAL1"      "GADD45GIP1"
##  [6] "MRPL1"      "MRPL10"     "MRPL11"     "MRPL12"     "MRPL13"    
## [11] "MRPL14"     "MRPL15"     "MRPL16"     "MRPL17"     "MRPL18"    
## [16] "MRPL19"     "MRPL2"      "MRPL20"     "MRPL21"     "MRPL22"    
## [21] "MRPL23"     "MRPL24"     "MRPL27"     "MRPL28"     "MRPL3"     
## [26] "MRPL30"     "MRPL32"     "MRPL33"     "MRPL34"     "MRPL35"    
## [31] "MRPL36"     "MRPL37"     "MRPL38"     "MRPL39"     "MRPL4"     
## [36] "MRPL40"     "MRPL41"     "MRPL42"     "MRPL43"     "MRPL44"    
## [41] "MRPL45"     "MRPL46"     "MRPL47"     "MRPL48"     "MRPL49"    
## [46] "MRPL50"     "MRPL51"     "MRPL52"     "MRPL53"     "MRPL54"    
## [51] "MRPL55"     "MRPL57"     "MRPL58"     "MRPL9"      "MRPS10"    
## [56] "MRPS11"     "MRPS14"     "MRPS15"     "MRPS16"     "MRPS17"    
## [61] "MRPS18A"    "MRPS18B"    "MRPS18C"    "MRPS2"      "MRPS21"    
## [66] "MRPS22"     "MRPS23"     "MRPS24"     "MRPS25"     "MRPS26"    
## [71] "MRPS27"     "MRPS28"     "MRPS30"     "MRPS31"     "MRPS33"    
## [76] "MRPS34"     "MRPS35"     "MRPS36"     "MRPS5"      "MRPS6"     
## [81] "MRPS7"      "MRPS9"      "MT-RNR1"    "MT-RNR2"    "MTFMT"     
## [86] "MTIF2"      "MTIF3"      "OXA1L"      "PTCD3"      "RPS12"     
## 
## [[1]]$`DOWN genesets.Modulation by Mtb of host immune system`
## [1] "B2M"    "MRC1"   "RPS27A" "TLR2"   "UBA52"  "UBB"    "UBC"   
## 
## [[1]]$`DOWN genesets.Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)`
##  [1] "EIF4G1"  "ETF1"    "FAU"     "GSPT1"   "GSPT2"   "NCBP1"   "NCBP2"  
##  [8] "PABPC1"  "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A" 
## [15] "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"  
## [22] "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1"
## [29] "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"  
## [36] "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL"
## [43] "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"   
## [50] "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"   
## [57] "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"  
## [64] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
## [71] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
## [78] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
## [85] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
## [92] "RPSA"    "UBA52"   "UPF1"   
## 
## [[1]]$`DOWN genesets.Peptide chain elongation`
##  [1] "EEF1A1"  "EEF2"    "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"  
##  [8] "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A" 
## [15] "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"  
## [22] "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"   
## [29] "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"  
## [36] "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L" 
## [43] "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"  
## [50] "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"  
## [57] "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"  
## [64] "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"  
## [71] "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"  
## [78] "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"   
## [85] "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.SARS-CoV-1 modulates host translation machinery`
##  [1] "EEF1A1"  "FAU"     "HNRNPA1" "RPS10"   "RPS11"   "RPS12"   "RPS13"  
##  [8] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
## [15] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
## [22] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
## [29] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
## [36] "RPSA"   
## 
## [[1]]$`DOWN genesets.SRP-dependent cotranslational protein targeting to membrane`
##   [1] "DDOST"   "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"  
##   [8] "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"  
##  [15] "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"  
##  [22] "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"  
##  [29] "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A" 
##  [36] "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL3L"  
##  [43] "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"   
##  [50] "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPN1"    "RPN2"    "RPS10"  
##  [57] "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"  
##  [64] "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"  
##  [71] "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"  
##  [78] "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"   
##  [85] "RPS7"    "RPS8"    "RPS9"    "RPSA"    "SEC11A"  "SEC11C"  "SEC61A1"
##  [92] "SEC61A2" "SEC61B"  "SEC61G"  "SPCS1"   "SPCS2"   "SPCS3"   "SRP14"  
##  [99] "SRP19"   "SRP54"   "SRP68"   "SRP72"   "SRP9"    "SRPRA"   "SRPRB"  
## [106] "SSR1"    "SSR2"    "SSR3"    "SSR4"    "TRAM1"   "UBA52"  
## 
## [[1]]$`DOWN genesets.Selenocysteine synthesis`
##  [1] "EEFSEC"   "FAU"      "PSTK"     "RPL10"    "RPL10A"   "RPL11"   
##  [7] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
## [13] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
## [19] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
## [25] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
## [31] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
## [37] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
## [43] "RPL3L"    "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"    
## [49] "RPL7A"    "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"   
## [55] "RPS10"    "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"   
## [61] "RPS15A"   "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"    
## [67] "RPS20"    "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"   
## [73] "RPS27"    "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"    
## [79] "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"    
## [85] "RPS8"     "RPS9"     "RPSA"     "SARS1"    "SECISBP2" "SEPHS2"  
## [91] "SEPSECS"  "UBA52"   
## 
## [[1]]$`DOWN genesets.Translation initiation complex formation`
##  [1] "EIF1AX" "EIF2S1" "EIF2S2" "EIF2S3" "EIF3A"  "EIF3B"  "EIF3C"  "EIF3D" 
##  [9] "EIF3E"  "EIF3F"  "EIF3G"  "EIF3H"  "EIF3I"  "EIF3J"  "EIF3K"  "EIF3L" 
## [17] "EIF3M"  "EIF4A1" "EIF4A2" "EIF4B"  "EIF4E"  "EIF4G1" "EIF4H"  "FAU"   
## [25] "PABPC1" "RPS10"  "RPS11"  "RPS12"  "RPS13"  "RPS14"  "RPS15"  "RPS15A"
## [33] "RPS16"  "RPS17"  "RPS18"  "RPS19"  "RPS2"   "RPS20"  "RPS21"  "RPS23" 
## [41] "RPS24"  "RPS25"  "RPS26"  "RPS27"  "RPS27A" "RPS27L" "RPS28"  "RPS29" 
## [49] "RPS3"   "RPS3A"  "RPS4X"  "RPS4Y1" "RPS5"   "RPS6"   "RPS7"   "RPS8"  
## [57] "RPS9"   "RPSA"  
## 
## [[1]]$`DOWN genesets.Viral mRNA Translation`
##  [1] "DNAJC3"  "FAU"     "GRSF1"   "RPL10"   "RPL10A"  "RPL11"   "RPL12"  
##  [8] "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A" 
## [15] "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"  
## [22] "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"   
## [29] "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"  
## [36] "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L" 
## [43] "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"  
## [50] "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"  
## [57] "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"  
## [64] "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"  
## [71] "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"  
## [78] "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"   
## [85] "RPS8"    "RPS9"    "RPSA"    "UBA52"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report