Mitch Report

date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-1.8296569
A1BG	-1.6816675
A1BG-AS1	-0.1542763
A1CF	1.0483615
A2M	1.7385456
A2M-AS1	0.9893940

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2725
num_genes_in_profile	21870
duplicated_genes_present	0
num_profile_genes_in_sets	8802
num_profile_genes_not_in_sets	13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1189
num_genesets_included	1536

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Modulation by Mtb of host immune system	7	1.74e-04	-0.819	9.46e-04
Peptide chain elongation	87	1.12e-39	-0.816	1.08e-37
Maturation of spike protein 9683686	5	1.77e-03	-0.807	7.15e-03
Viral mRNA Translation	87	9.09e-39	-0.806	7.96e-37
Formation of ATP by chemiosmotic coupling	20	6.05e-10	-0.799	7.82e-09
Eukaryotic Translation Elongation	92	5.11e-40	-0.797	5.18e-38
Formation of a pool of free 40S subunits	99	7.16e-42	-0.787	9.19e-40
SARS-CoV-1 modulates host translation machinery	36	3.16e-16	-0.786	8.47e-15
Eukaryotic Translation Termination	91	3.33e-38	-0.782	2.67e-36
Glycosphingolipid transport	7	4.07e-04	-0.772	2.04e-03
Selenocysteine synthesis	91	8.71e-37	-0.767	6.21e-35
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	2.12e-37	-0.765	1.57e-35
Sulfide oxidation to sulfate	5	3.28e-03	-0.759	1.21e-02
SRP-dependent cotranslational protein targeting to membrane	110	6.09e-43	-0.757	9.78e-41
L13a-mediated translational silencing of Ceruloplasmin expression	109	5.47e-42	-0.751	7.53e-40
Formation of annular gap junctions	10	4.28e-05	-0.747	2.57e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	110	8.06e-41	-0.737	8.63e-39
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	4.83e-03	-0.728	1.63e-02
Phosphate bond hydrolysis by NUDT proteins	7	9.24e-04	-0.723	4.08e-03
Cap-dependent Translation Initiation	117	1.23e-41	-0.722	1.39e-39
Eukaryotic Translation Initiation	117	1.23e-41	-0.722	1.39e-39
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	1.99e-35	-0.721	1.28e-33
Formation of the ternary complex, and subsequently, the 43S complex	51	4.30e-18	-0.701	1.36e-16
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.07e-19	-0.683	3.98e-18
Translation initiation complex formation	58	3.54e-19	-0.679	1.22e-17
Ribosomal scanning and start codon recognition	58	8.84e-19	-0.671	2.94e-17
SUMO is conjugated to E1 (UBA2:SAE1)	5	9.59e-03	-0.669	2.86e-02
Fructose metabolism	7	2.23e-03	-0.667	8.79e-03
Selenoamino acid metabolism	114	9.63e-35	-0.665	5.99e-33
Prevention of phagosomal-lysosomal fusion	9	5.89e-04	-0.661	2.78e-03
VLDLR internalisation and degradation	15	9.51e-06	-0.660	6.27e-05
Nef Mediated CD4 Down-regulation	9	6.76e-04	-0.654	3.15e-03
Abacavir ADME	5	1.16e-02	0.652	3.34e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.21e-02	-0.648	3.43e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	7.76e-04	-0.647	3.52e-03
Regulation of expression of SLITs and ROBOs	148	3.66e-42	-0.647	5.43e-40
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.23e-02	-0.646	3.49e-02
Formation of xylulose-5-phosphate	5	1.27e-02	-0.643	3.59e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.37e-02	-0.636	3.81e-02
FLT3 signaling by CBL mutants	7	3.56e-03	-0.636	1.28e-02
Pentose phosphate pathway	13	7.54e-05	-0.634	4.35e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	1.22e-30	-0.626	6.04e-29
Nonsense-Mediated Decay (NMD)	113	1.22e-30	-0.626	6.04e-29
Protein repair	6	7.98e-03	-0.625	2.50e-02
Ethanol oxidation	7	4.23e-03	-0.624	1.48e-02
Defective CFTR causes cystic fibrosis	47	1.75e-13	-0.621	3.78e-12
Formyl peptide receptors bind formyl peptides and many other ligands	7	4.58e-03	-0.619	1.57e-02
Josephin domain DUBs	10	7.10e-04	-0.618	3.28e-03
Cellular response to starvation	147	1.10e-37	-0.612	8.50e-36
SARS-CoV-2 modulates host translation machinery	49	1.44e-13	-0.610	3.15e-12

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Modulation by Mtb of host immune system	7	1.74e-04	-0.819000	9.46e-04
Peptide chain elongation	87	1.12e-39	-0.816000	1.08e-37
Maturation of spike protein 9683686	5	1.77e-03	-0.807000	7.15e-03
Viral mRNA Translation	87	9.09e-39	-0.806000	7.96e-37
Formation of ATP by chemiosmotic coupling	20	6.05e-10	-0.799000	7.82e-09
Eukaryotic Translation Elongation	92	5.11e-40	-0.797000	5.18e-38
Formation of a pool of free 40S subunits	99	7.16e-42	-0.787000	9.19e-40
SARS-CoV-1 modulates host translation machinery	36	3.16e-16	-0.786000	8.47e-15
Eukaryotic Translation Termination	91	3.33e-38	-0.782000	2.67e-36
Glycosphingolipid transport	7	4.07e-04	-0.772000	2.04e-03
Selenocysteine synthesis	91	8.71e-37	-0.767000	6.21e-35
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	2.12e-37	-0.765000	1.57e-35
Sulfide oxidation to sulfate	5	3.28e-03	-0.759000	1.21e-02
SRP-dependent cotranslational protein targeting to membrane	110	6.09e-43	-0.757000	9.78e-41
L13a-mediated translational silencing of Ceruloplasmin expression	109	5.47e-42	-0.751000	7.53e-40
Formation of annular gap junctions	10	4.28e-05	-0.747000	2.57e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	110	8.06e-41	-0.737000	8.63e-39
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	4.83e-03	-0.728000	1.63e-02
Phosphate bond hydrolysis by NUDT proteins	7	9.24e-04	-0.723000	4.08e-03
Cap-dependent Translation Initiation	117	1.23e-41	-0.722000	1.39e-39
Eukaryotic Translation Initiation	117	1.23e-41	-0.722000	1.39e-39
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	1.99e-35	-0.721000	1.28e-33
Formation of the ternary complex, and subsequently, the 43S complex	51	4.30e-18	-0.701000	1.36e-16
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.07e-19	-0.683000	3.98e-18
Translation initiation complex formation	58	3.54e-19	-0.679000	1.22e-17
Ribosomal scanning and start codon recognition	58	8.84e-19	-0.671000	2.94e-17
SUMO is conjugated to E1 (UBA2:SAE1)	5	9.59e-03	-0.669000	2.86e-02
Fructose metabolism	7	2.23e-03	-0.667000	8.79e-03
Selenoamino acid metabolism	114	9.63e-35	-0.665000	5.99e-33
Prevention of phagosomal-lysosomal fusion	9	5.89e-04	-0.661000	2.78e-03
VLDLR internalisation and degradation	15	9.51e-06	-0.660000	6.27e-05
Nef Mediated CD4 Down-regulation	9	6.76e-04	-0.654000	3.15e-03
Abacavir ADME	5	1.16e-02	0.652000	3.34e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.21e-02	-0.648000	3.43e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	7.76e-04	-0.647000	3.52e-03
Regulation of expression of SLITs and ROBOs	148	3.66e-42	-0.647000	5.43e-40
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.23e-02	-0.646000	3.49e-02
Formation of xylulose-5-phosphate	5	1.27e-02	-0.643000	3.59e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.37e-02	-0.636000	3.81e-02
FLT3 signaling by CBL mutants	7	3.56e-03	-0.636000	1.28e-02
Pentose phosphate pathway	13	7.54e-05	-0.634000	4.35e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	1.22e-30	-0.626000	6.04e-29
Nonsense-Mediated Decay (NMD)	113	1.22e-30	-0.626000	6.04e-29
Protein repair	6	7.98e-03	-0.625000	2.50e-02
Ethanol oxidation	7	4.23e-03	-0.624000	1.48e-02
Defective CFTR causes cystic fibrosis	47	1.75e-13	-0.621000	3.78e-12
Formyl peptide receptors bind formyl peptides and many other ligands	7	4.58e-03	-0.619000	1.57e-02
Josephin domain DUBs	10	7.10e-04	-0.618000	3.28e-03
Cellular response to starvation	147	1.10e-37	-0.612000	8.50e-36
SARS-CoV-2 modulates host translation machinery	49	1.44e-13	-0.610000	3.15e-12
Hh mutants are degraded by ERAD	42	9.38e-12	-0.607000	1.77e-10
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	2.05e-10	-0.604000	3.04e-09
Regulation of ornithine decarboxylase (ODC)	38	1.18e-10	-0.604000	1.86e-09
Gap junction degradation	11	5.56e-04	-0.601000	2.63e-03
Vif-mediated degradation of APOBEC3G	41	3.15e-11	-0.599000	5.39e-10
Hh mutants abrogate ligand secretion	43	1.18e-11	-0.597000	2.17e-10
GDP-fucose biosynthesis	6	1.13e-02	-0.597000	3.27e-02
Retrograde neurotrophin signalling	12	3.66e-04	-0.594000	1.86e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	1.46e-10	-0.593000	2.23e-09
p53-Independent DNA Damage Response	39	1.46e-10	-0.593000	2.23e-09
p53-Independent G1/S DNA damage checkpoint	39	1.46e-10	-0.593000	2.23e-09
Vpu mediated degradation of CD4	39	1.62e-10	-0.591000	2.45e-09
Influenza Viral RNA Transcription and Replication	134	4.79e-32	-0.589000	2.64e-30
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	1.25e-02	-0.588000	3.54e-02
Pyrimidine salvage	10	1.31e-03	-0.587000	5.55e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	4.66e-11	-0.587000	7.60e-10
Nef Mediated CD8 Down-regulation	7	7.46e-03	-0.584000	2.37e-02
p75NTR recruits signalling complexes	12	4.61e-04	-0.584000	2.24e-03
Cross-presentation of soluble exogenous antigens (endosomes)	35	2.23e-09	-0.584000	2.57e-08
Metabolism of polyamines	46	7.65e-12	-0.583000	1.47e-10
Cristae formation	33	6.75e-09	-0.583000	7.11e-08
CS/DS degradation	9	2.56e-03	-0.580000	9.86e-03
Autodegradation of the E3 ubiquitin ligase COP1	38	5.98e-10	-0.580000	7.82e-09
Sema4D mediated inhibition of cell attachment and migration	7	7.87e-03	-0.580000	2.48e-02
Classical antibody-mediated complement activation	70	4.58e-17	-0.580000	1.36e-15
Ubiquitin-dependent degradation of Cyclin D	39	3.79e-10	-0.579000	5.30e-09
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	4.72e-03	-0.577000	1.60e-02
Negative regulation of NOTCH4 signaling	44	3.67e-11	-0.576000	6.10e-10
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.04e-03	-0.571000	4.49e-03
Translation	292	1.37e-63	-0.571000	8.80e-61
Mitochondrial translation elongation	90	8.28e-21	-0.570000	3.39e-19
Fructose catabolism	5	2.73e-02	-0.570000	6.62e-02
Hedgehog ligand biogenesis	47	1.44e-11	-0.569000	2.62e-10
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	9.14e-03	-0.569000	2.75e-02
FLT3 signaling through SRC family kinases	6	1.59e-02	-0.568000	4.29e-02
Activation of RAC1 downstream of NMDARs	7	9.38e-03	-0.567000	2.81e-02
Degradation of DVL	43	1.48e-10	-0.564000	2.25e-09
Protein hydroxylation	17	5.71e-05	-0.564000	3.38e-04
Creation of C4 and C2 activators	72	1.30e-16	-0.563000	3.63e-15
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	4.36e-10	-0.563000	5.88e-09
p75NTR negatively regulates cell cycle via SC1	5	2.95e-02	-0.562000	7.07e-02
WNT5A-dependent internalization of FZD4	13	4.70e-04	-0.560000	2.27e-03
Citric acid cycle (TCA cycle)	34	2.11e-08	-0.555000	2.06e-07
Asymmetric localization of PCP proteins	49	1.97e-11	-0.554000	3.51e-10
Advanced glycosylation endproduct receptor signaling	12	9.06e-04	-0.553000	4.02e-03
Signaling by ROBO receptors	188	5.68e-39	-0.551000	5.21e-37
Mitochondrial protein import	63	4.03e-14	-0.550000	9.25e-13
Regulation of Apoptosis	40	1.83e-09	-0.549000	2.14e-08
Mitochondrial translation initiation	90	2.75e-19	-0.547000	9.63e-18
SCF-beta-TrCP mediated degradation of Emi1	42	1.07e-09	-0.544000	1.33e-08
Scavenging of heme from plasma	71	2.79e-15	-0.542000	6.80e-14
Influenza Infection	153	6.69e-31	-0.541000	3.49e-29
Negative feedback regulation of MAPK pathway	6	2.19e-02	-0.540000	5.58e-02
Mitochondrial translation termination	90	1.88e-18	-0.534000	6.13e-17
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	3.87e-02	-0.534000	8.73e-02
Glyoxylate metabolism and glycine degradation	13	8.61e-04	-0.534000	3.84e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	2.46e-09	-0.532000	2.79e-08
Abortive elongation of HIV-1 transcript in the absence of Tat	23	1.14e-05	-0.529000	7.45e-05
Degradation of GLI2 by the proteasome	45	8.90e-10	-0.528000	1.14e-08
Complex III assembly	23	1.20e-05	-0.527000	7.83e-05
Complex I biogenesis	66	1.36e-13	-0.526000	3.01e-12
Hyaluronan uptake and degradation	12	1.62e-03	-0.525000	6.68e-03
Initial triggering of complement	80	4.79e-16	-0.525000	1.23e-14
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	2.61e-02	-0.524000	6.39e-02
Aryl hydrocarbon receptor signalling	6	2.64e-02	-0.523000	6.42e-02
Respiratory electron transport	149	2.56e-28	-0.523000	1.23e-26
GLI3 is processed to GLI3R by the proteasome	46	1.01e-09	-0.520000	1.29e-08
FCGR activation	77	2.96e-15	-0.520000	7.12e-14
RNA Polymerase I Promoter Opening	17	2.12e-04	-0.519000	1.12e-03
NF-kB is activated and signals survival	12	1.92e-03	-0.517000	7.72e-03
CD22 mediated BCR regulation	59	7.99e-12	-0.514000	1.53e-10
Maturation of TCA enzymes and regulation of TCA cycle	20	7.00e-05	-0.514000	4.06e-04
Mitochondrial translation	96	3.26e-18	-0.513000	1.05e-16
Degradation of AXIN	42	8.57e-09	-0.513000	8.92e-08
Dermatan sulfate biosynthesis	6	2.97e-02	-0.513000	7.08e-02
Pausing and recovery of Tat-mediated HIV elongation	30	1.27e-06	-0.511000	9.42e-06
Tat-mediated HIV elongation arrest and recovery	30	1.27e-06	-0.511000	9.42e-06
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	4.08e-04	-0.510000	2.04e-03
Miscellaneous substrates	8	1.25e-02	0.510000	3.54e-02
Spry regulation of FGF signaling	16	4.29e-04	-0.508000	2.11e-03
Beta-oxidation of pristanoyl-CoA	9	8.26e-03	-0.508000	2.57e-02
Major pathway of rRNA processing in the nucleolus and cytosol	179	9.63e-32	-0.507000	5.15e-30
Gluconeogenesis	19	1.30e-04	-0.507000	7.17e-04
Mitochondrial calcium ion transport	22	3.83e-05	-0.507000	2.31e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	2.17e-07	-0.506000	1.77e-06
rRNA processing in the nucleus and cytosol	189	2.78e-33	-0.506000	1.57e-31
Regulation of RUNX3 expression and activity	45	4.19e-09	-0.506000	4.54e-08
Synthesis of GDP-mannose	6	3.23e-02	-0.505000	7.63e-02
Proteasome assembly	51	4.81e-10	-0.504000	6.40e-09
Complex IV assembly	45	5.13e-09	-0.503000	5.46e-08
Assembly Of The HIV Virion	15	7.56e-04	-0.502000	3.44e-03
Phenylalanine metabolism	5	5.25e-02	-0.501000	1.13e-01
Degradation of cysteine and homocysteine	12	2.75e-03	-0.499000	1.04e-02
Role of LAT2/NTAL/LAB on calcium mobilization	78	2.55e-14	-0.499000	5.91e-13
DNA methylation	18	2.71e-04	-0.496000	1.41e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	5.73e-05	-0.495000	3.38e-04
Stabilization of p53	43	1.91e-08	-0.495000	1.88e-07
Folding of actin by CCT/TriC	10	7.21e-03	-0.491000	2.32e-02
Metabolism of folate and pterines	16	7.03e-04	-0.489000	3.26e-03
IRE1alpha activates chaperones	46	1.02e-08	-0.488000	1.05e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	1.16e-09	-0.488000	1.43e-08
Dectin-1 mediated noncanonical NF-kB signaling	48	5.54e-09	-0.486000	5.87e-08
Suppression of phagosomal maturation	12	3.54e-03	-0.486000	1.28e-02
NIK–>noncanonical NF-kB signaling	46	1.17e-08	-0.486000	1.19e-07
Pexophagy	10	7.82e-03	-0.486000	2.47e-02
rRNA processing	213	2.41e-34	-0.485000	1.45e-32
PCP/CE pathway	75	3.69e-13	-0.485000	7.81e-12
MASTL Facilitates Mitotic Progression	10	7.93e-03	-0.485000	2.49e-02
Degradation of GLI1 by the proteasome	46	1.31e-08	-0.484000	1.33e-07
XBP1(S) activates chaperone genes	44	2.85e-08	-0.483000	2.74e-07
APC/C:Cdc20 mediated degradation of Securin	55	6.23e-10	-0.482000	8.01e-09
Aerobic respiration and respiratory electron transport	245	1.18e-38	-0.481000	9.85e-37
Mitochondrial protein degradation	96	3.79e-16	-0.481000	9.99e-15
The role of GTSE1 in G2/M progression after G2 checkpoint	59	1.72e-10	-0.480000	2.57e-09
Calnexin/calreticulin cycle	26	2.30e-05	-0.480000	1.44e-04
Autodegradation of Cdh1 by Cdh1:APC/C	54	1.22e-09	-0.478000	1.49e-08
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	9.41e-04	-0.478000	4.13e-03
RHOBTB3 ATPase cycle	10	9.14e-03	-0.476000	2.75e-02
Somitogenesis	41	1.38e-07	-0.475000	1.18e-06
Prostanoid ligand receptors	8	2.03e-02	-0.474000	5.24e-02
Replacement of protamines by nucleosomes in the male pronucleus	13	3.11e-03	-0.474000	1.16e-02
Fatty acids	8	2.07e-02	0.472000	5.31e-02
Maturation of spike protein 9694548	36	9.45e-07	-0.472000	7.22e-06
Synthesis of Dolichyl-phosphate	6	4.54e-02	-0.472000	9.98e-02
ER-Phagosome pathway	75	1.61e-12	-0.472000	3.22e-11
Glycogen synthesis	11	6.77e-03	-0.471000	2.21e-02
Mucopolysaccharidoses	11	6.79e-03	-0.471000	2.21e-02
Cellular response to hypoxia	59	3.74e-10	-0.471000	5.26e-09
Regulation of RAS by GAPs	55	1.48e-09	-0.471000	1.77e-08
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	11	6.89e-03	-0.470000	2.23e-02
Defective EXT2 causes exostoses 2	11	6.89e-03	-0.470000	2.23e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	1.93e-04	-0.470000	1.04e-03
Inhibition of DNA recombination at telomere	33	2.98e-06	-0.470000	2.17e-05
Expression and translocation of olfactory receptors	52	4.56e-09	0.470000	4.91e-08
ERKs are inactivated	13	3.38e-03	-0.469000	1.23e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	7.35e-03	-0.467000	2.34e-02
PDH complex synthesizes acetyl-CoA from PYR	5	7.08e-02	-0.467000	1.43e-01
FCERI mediated NF-kB activation	130	4.23e-20	-0.466000	1.63e-18
p75NTR signals via NF-kB	15	1.82e-03	-0.465000	7.35e-03
Glutamate and glutamine metabolism	12	5.31e-03	-0.465000	1.77e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	12	5.33e-03	-0.465000	1.78e-02
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	7.38e-02	-0.462000	1.48e-01
SLBP independent Processing of Histone Pre-mRNAs	10	1.16e-02	-0.461000	3.34e-02
Malate-aspartate shuttle	8	2.41e-02	-0.461000	6.02e-02
Diseases of carbohydrate metabolism	29	1.79e-05	-0.460000	1.15e-04
Packaging Of Telomere Ends	18	7.24e-04	-0.460000	3.32e-03
Binding and Uptake of Ligands by Scavenger Receptors	93	1.67e-14	-0.460000	3.92e-13
G2/M DNA replication checkpoint	5	7.56e-02	-0.459000	1.51e-01
The NLRP3 inflammasome	16	1.48e-03	-0.459000	6.17e-03
Membrane binding and targetting of GAG proteins	13	4.37e-03	-0.457000	1.51e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	4.37e-03	-0.457000	1.51e-02
Infection with Mycobacterium tuberculosis	26	5.81e-05	-0.455000	3.40e-04
ABC transporter disorders	60	1.12e-09	-0.455000	1.38e-08
HIV elongation arrest and recovery	32	8.59e-06	-0.454000	5.71e-05
Pausing and recovery of HIV elongation	32	8.59e-06	-0.454000	5.71e-05
Zinc influx into cells by the SLC39 gene family	9	1.84e-02	-0.454000	4.84e-02
A tetrasaccharide linker sequence is required for GAG synthesis	18	9.20e-04	-0.451000	4.08e-03
Chondroitin sulfate/dermatan sulfate metabolism	39	1.18e-06	-0.450000	8.87e-06
Glycosphingolipid catabolism	31	1.54e-05	-0.449000	9.90e-05
SCF(Skp2)-mediated degradation of p27/p21	50	4.76e-08	-0.446000	4.34e-07
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	2.50e-09	-0.445000	2.82e-08
Role of phospholipids in phagocytosis	89	3.98e-13	-0.445000	8.35e-12
TGFBR3 PTM regulation	10	1.49e-02	-0.444000	4.04e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	1.94e-09	-0.444000	2.25e-08
Signal attenuation	9	2.13e-02	-0.443000	5.45e-02
LDL clearance	17	1.60e-03	-0.442000	6.60e-03
CDK-mediated phosphorylation and removal of Cdc6	60	3.18e-09	-0.442000	3.55e-08
p53-Dependent G1 DNA Damage Response	52	3.78e-08	-0.441000	3.51e-07
p53-Dependent G1/S DNA damage checkpoint	52	3.78e-08	-0.441000	3.51e-07
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	2.48e-10	-0.440000	3.59e-09
mTORC1-mediated signalling	24	1.88e-04	-0.440000	1.01e-03
Regulation of PTEN stability and activity	55	1.63e-08	-0.440000	1.62e-07
Defective B4GALT7 causes EDS, progeroid type	12	8.35e-03	-0.440000	2.58e-02
FCGR3A-mediated phagocytosis	122	5.11e-17	-0.439000	1.45e-15
Leishmania phagocytosis	122	5.11e-17	-0.439000	1.45e-15
Parasite infection	122	5.11e-17	-0.439000	1.45e-15
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	1.18e-02	-0.439000	3.37e-02
Tandem pore domain potassium channels	5	8.97e-02	-0.438000	1.72e-01
G1/S DNA Damage Checkpoints	54	2.57e-08	-0.438000	2.48e-07
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	1.48e-09	-0.437000	1.77e-08
Lysosome Vesicle Biogenesis	32	1.93e-05	-0.436000	1.23e-04
Interconversion of nucleotide di- and triphosphates	27	8.66e-05	-0.436000	4.95e-04
Platelet sensitization by LDL	16	2.54e-03	-0.436000	9.79e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	4.13e-09	-0.435000	4.50e-08
APC/C:Cdc20 mediated degradation of mitotic proteins	63	2.31e-09	-0.435000	2.64e-08
Regulation of RUNX2 expression and activity	54	3.19e-08	-0.435000	3.03e-07
Prefoldin mediated transfer of substrate to CCT/TriC	25	1.69e-04	-0.435000	9.20e-04
Orc1 removal from chromatin	58	1.47e-08	-0.430000	1.48e-07
Hyaluronan metabolism	15	4.03e-03	-0.429000	1.43e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	6.89e-02	-0.429000	1.41e-01
Cleavage of the damaged purine	22	4.99e-04	-0.429000	2.38e-03
Depurination	22	4.99e-04	-0.429000	2.38e-03
Recognition and association of DNA glycosylase with site containing an affected purine	22	4.99e-04	-0.429000	2.38e-03
Processing of SMDT1	15	4.06e-03	-0.428000	1.43e-02
Formation of the Early Elongation Complex	33	2.07e-05	-0.428000	1.30e-04
Formation of the HIV-1 Early Elongation Complex	33	2.07e-05	-0.428000	1.30e-04
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	9.38e-08	-0.428000	8.14e-07
Regulation of actin dynamics for phagocytic cup formation	124	1.95e-16	-0.427000	5.36e-15
Killing mechanisms	10	1.95e-02	-0.427000	5.07e-02
WNT5:FZD7-mediated leishmania damping	10	1.95e-02	-0.427000	5.07e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	1.44e-02	-0.426000	3.94e-02
Defective B3GAT3 causes JDSSDHD	12	1.06e-02	-0.426000	3.13e-02
Degradation of beta-catenin by the destruction complex	72	4.06e-10	-0.426000	5.63e-09
Plasma lipoprotein clearance	32	3.06e-05	-0.426000	1.88e-04
Activation of NF-kappaB in B cells	54	7.06e-08	-0.424000	6.27e-07
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	5.23e-02	-0.423000	1.12e-01
Chondroitin sulfate biosynthesis	12	1.11e-02	-0.423000	3.25e-02
Activation of NOXA and translocation to mitochondria	5	1.01e-01	-0.423000	1.91e-01
Protein localization	157	6.26e-20	-0.422000	2.37e-18
FCERI mediated MAPK activation	94	1.50e-12	-0.422000	3.04e-11
ATF6 (ATF6-alpha) activates chaperones	12	1.15e-02	-0.421000	3.31e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	2.11e-02	-0.421000	5.41e-02
The role of Nef in HIV-1 replication and disease pathogenesis	28	1.18e-04	-0.420000	6.59e-04
Metabolism of amino acids and derivatives	305	1.82e-36	-0.419000	1.25e-34
Nuclear events mediated by NFE2L2	82	5.46e-11	-0.419000	8.85e-10
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	1.25e-04	-0.419000	6.97e-04
Noncanonical activation of NOTCH3	8	4.07e-02	-0.418000	9.11e-02
Frs2-mediated activation	11	1.64e-02	-0.418000	4.38e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	1.30e-04	-0.418000	7.17e-04
Response of Mtb to phagocytosis	22	6.96e-04	-0.418000	3.24e-03
Signaling by NOTCH4	68	2.67e-09	-0.417000	2.99e-08
Arachidonate production from DAG	5	1.07e-01	-0.417000	1.99e-01
Purine catabolism	16	3.96e-03	-0.416000	1.41e-02
FCGR3A-mediated IL10 synthesis	100	7.65e-13	-0.415000	1.59e-11
Nef mediated downregulation of MHC class I complex cell surface expression	10	2.32e-02	-0.415000	5.85e-02
Regulation of APC/C activators between G1/S and early anaphase	68	3.44e-09	-0.414000	3.79e-08
Regulation of Complement cascade	97	1.77e-12	-0.414000	3.51e-11
Myoclonic epilepsy of Lafora	8	4.31e-02	-0.413000	9.55e-02
UCH proteinases	73	1.07e-09	-0.413000	1.33e-08
Cytosolic sulfonation of small molecules	18	2.47e-03	-0.412000	9.63e-03
Cytosolic iron-sulfur cluster assembly	13	1.01e-02	-0.412000	3.00e-02
Erythrocytes take up oxygen and release carbon dioxide	7	5.94e-02	0.411000	1.25e-01
Synthesis of pyrophosphates in the cytosol	8	4.49e-02	-0.410000	9.90e-02
Complement cascade	101	1.16e-12	-0.409000	2.38e-11
Antigen processing-Cross presentation	89	2.56e-11	-0.409000	4.48e-10
NRIF signals cell death from the nucleus	15	6.11e-03	-0.409000	2.00e-02
Methionine salvage pathway	6	8.29e-02	-0.409000	1.62e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	2.52e-02	-0.409000	6.22e-02
Ubiquinol biosynthesis	13	1.10e-02	-0.407000	3.21e-02
Nucleotide biosynthesis	12	1.48e-02	-0.406000	4.02e-02
Sulfur amino acid metabolism	22	1.01e-03	-0.405000	4.39e-03
Heparan sulfate/heparin (HS-GAG) metabolism	41	7.54e-06	-0.404000	5.08e-05
Golgi Cisternae Pericentriolar Stack Reorganization	14	9.07e-03	-0.403000	2.73e-02
Olfactory Signaling Pathway	57	1.54e-07	0.402000	1.28e-06
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	6.79e-06	-0.401000	4.61e-05
HIV Transcription Elongation	42	6.79e-06	-0.401000	4.61e-05
Tat-mediated elongation of the HIV-1 transcript	42	6.79e-06	-0.401000	4.61e-05
DNA Damage Recognition in GG-NER	38	1.90e-05	-0.401000	1.22e-04
Translation of Structural Proteins 9694635	56	2.12e-07	-0.401000	1.74e-06
RNA Pol II CTD phosphorylation and interaction with CE	27	3.22e-04	-0.400000	1.66e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	3.22e-04	-0.400000	1.66e-03
mRNA Splicing - Minor Pathway	50	1.01e-06	-0.400000	7.66e-06
Regulation of mRNA stability by proteins that bind AU-rich elements	76	1.69e-09	-0.400000	2.00e-08
Late SARS-CoV-2 Infection Events	64	3.31e-08	-0.399000	3.12e-07
Release of apoptotic factors from the mitochondria	6	9.06e-02	-0.399000	1.74e-01
DNA Replication Pre-Initiation	103	2.61e-12	-0.399000	5.07e-11
Formation of paraxial mesoderm	52	7.04e-07	-0.398000	5.51e-06
FCERI mediated Ca+2 mobilization	93	3.51e-11	-0.397000	5.88e-10
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	6.91e-02	-0.397000	1.41e-01
Axonal growth inhibition (RHOA activation)	7	6.92e-02	-0.397000	1.41e-01
p75NTR regulates axonogenesis	7	6.92e-02	-0.397000	1.41e-01
Budding and maturation of HIV virion	26	4.65e-04	-0.397000	2.25e-03
Diseases associated with glycosaminoglycan metabolism	26	4.73e-04	-0.396000	2.27e-03
Beta-catenin phosphorylation cascade	17	4.72e-03	-0.396000	1.60e-02
Inactivation of CSF3 (G-CSF) signaling	24	7.98e-04	-0.395000	3.61e-03
ER Quality Control Compartment (ERQC)	21	1.75e-03	-0.394000	7.12e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	84	4.11e-10	-0.394000	5.64e-09
Assembly of the pre-replicative complex	87	2.15e-10	-0.394000	3.17e-09
Acyl chain remodeling of CL	5	1.29e-01	-0.392000	2.29e-01
Attachment of GPI anchor to uPAR	7	7.31e-02	-0.391000	1.47e-01
Zinc transporters	12	1.90e-02	-0.391000	4.97e-02
RNA Polymerase III Chain Elongation	18	4.10e-03	-0.391000	1.44e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	1.97e-03	-0.390000	7.83e-03
Neurodegenerative Diseases	21	1.97e-03	-0.390000	7.83e-03
N-glycan trimming and elongation in the cis-Golgi	5	1.31e-01	-0.390000	2.31e-01
Metabolism of nucleotides	85	5.32e-10	-0.389000	7.02e-09
Biosynthesis of Lipoxins (LX)	6	1.01e-01	-0.387000	1.90e-01
Induction of Cell-Cell Fusion	8	5.84e-02	-0.386000	1.23e-01
MAPK3 (ERK1) activation	10	3.45e-02	-0.386000	8.01e-02
PINK1-PRKN Mediated Mitophagy	31	2.00e-04	-0.386000	1.07e-03
Phenylalanine and tyrosine metabolism	9	4.51e-02	-0.386000	9.92e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	8.58e-04	-0.385000	3.84e-03
Insulin receptor recycling	24	1.13e-03	-0.384000	4.83e-03
NFE2L2 regulating inflammation associated genes	5	1.38e-01	0.383000	2.41e-01
Fcgamma receptor (FCGR) dependent phagocytosis	148	8.07e-16	-0.383000	2.05e-14
RMTs methylate histone arginines	35	9.05e-05	-0.382000	5.16e-04
Cell recruitment (pro-inflammatory response)	25	9.41e-04	-0.382000	4.13e-03
Purinergic signaling in leishmaniasis infection	25	9.41e-04	-0.382000	4.13e-03
Signal transduction by L1	20	3.10e-03	-0.382000	1.15e-02
Amino acids regulate mTORC1	48	4.77e-06	-0.382000	3.34e-05
RUNX2 regulates genes involved in cell migration	6	1.07e-01	-0.380000	1.99e-01
Phosphorylation of Emi1	6	1.08e-01	-0.379000	2.01e-01
Signaling by the B Cell Receptor (BCR)	151	9.23e-16	-0.379000	2.31e-14
Anti-inflammatory response favouring Leishmania parasite infection	133	5.13e-14	-0.378000	1.15e-12
Leishmania parasite growth and survival	133	5.13e-14	-0.378000	1.15e-12
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	1.44e-01	0.378000	2.47e-01
Condensation of Prophase Chromosomes	27	7.00e-04	-0.377000	3.25e-03
Synthesis of Ketone Bodies	6	1.10e-01	-0.377000	2.04e-01
Signaling by CSF3 (G-CSF)	29	4.48e-04	-0.377000	2.18e-03
Caspase-mediated cleavage of cytoskeletal proteins	12	2.40e-02	-0.376000	6.02e-02
Neutrophil degranulation	456	3.28e-43	-0.376000	5.75e-41
SARS-CoV-1-host interactions	94	3.04e-10	-0.376000	4.37e-09
Signaling by FGFR2 IIIa TM	18	5.84e-03	-0.375000	1.93e-02
Negative regulation of FLT3	15	1.21e-02	-0.374000	3.43e-02
CTLA4 inhibitory signaling	21	2.99e-03	-0.374000	1.12e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	3.88e-04	-0.374000	1.95e-03
Nucleotide salvage	21	3.05e-03	-0.373000	1.14e-02
Activated point mutants of FGFR2	7	8.72e-02	0.373000	1.69e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.94e-03	-0.373000	7.81e-03
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.22e-02	-0.373000	7.62e-02
WNT mediated activation of DVL	8	6.80e-02	-0.373000	1.40e-01
Glycogen storage diseases	13	2.00e-02	-0.372000	5.19e-02
The activation of arylsulfatases	10	4.14e-02	-0.372000	9.25e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	4.15e-04	-0.372000	2.06e-03
IRAK1 recruits IKK complex	14	1.60e-02	-0.372000	4.29e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	1.60e-02	-0.372000	4.29e-02
Purine ribonucleoside monophosphate biosynthesis	9	5.37e-02	-0.371000	1.15e-01
Azathioprine ADME	20	4.07e-03	-0.371000	1.43e-02
HS-GAG degradation	20	4.07e-03	-0.371000	1.43e-02
Late endosomal microautophagy	30	4.40e-04	-0.371000	2.16e-03
Mitophagy	38	7.67e-05	-0.371000	4.41e-04
Defective Intrinsic Pathway for Apoptosis	24	1.68e-03	-0.370000	6.85e-03
Displacement of DNA glycosylase by APEX1	9	5.45e-02	-0.370000	1.16e-01
STAT5 Activation	7	9.05e-02	-0.369000	1.74e-01
Amyloid fiber formation	51	5.07e-06	-0.369000	3.53e-05
Diseases associated with N-glycosylation of proteins	20	4.27e-03	-0.369000	1.48e-02
SARS-CoV-2 modulates autophagy	11	3.49e-02	-0.367000	8.05e-02
Cellular response to chemical stress	179	2.53e-17	-0.367000	7.74e-16
Detoxification of Reactive Oxygen Species	30	5.22e-04	-0.366000	2.48e-03
tRNA processing in the mitochondrion	24	1.96e-03	-0.365000	7.82e-03
Base-Excision Repair, AP Site Formation	29	6.65e-04	-0.365000	3.12e-03
Formation of HIV elongation complex in the absence of HIV Tat	44	2.78e-05	-0.365000	1.72e-04
CTNNB1 S33 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
CTNNB1 S37 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
CTNNB1 S45 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
CTNNB1 T41 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
Signaling by CTNNB1 phospho-site mutants	15	1.44e-02	-0.365000	3.94e-02
Signaling by GSK3beta mutants	15	1.44e-02	-0.365000	3.94e-02
Synthesis of PG	8	7.42e-02	-0.365000	1.49e-01
Formation of TC-NER Pre-Incision Complex	51	6.83e-06	-0.364000	4.62e-05
Glycogen metabolism	22	3.16e-03	-0.364000	1.17e-02
Activation of BAD and translocation to mitochondria	15	1.48e-02	-0.363000	4.02e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	4.66e-02	-0.363000	1.02e-01
Eicosanoid ligand-binding receptors	13	2.34e-02	-0.363000	5.89e-02
KEAP1-NFE2L2 pathway	107	8.75e-11	-0.363000	1.41e-09
TGFBR3 regulates TGF-beta signaling	8	7.60e-02	-0.362000	1.51e-01
APC/C-mediated degradation of cell cycle proteins	75	5.89e-08	-0.362000	5.33e-07
Regulation of mitotic cell cycle	75	5.89e-08	-0.362000	5.33e-07
Cyclin E associated events during G1/S transition	73	8.89e-08	-0.362000	7.75e-07
HS-GAG biosynthesis	21	4.09e-03	-0.362000	1.44e-02
Pregnenolone biosynthesis	10	4.76e-02	-0.362000	1.03e-01
SUMOylation of DNA methylation proteins	16	1.23e-02	-0.362000	3.48e-02
Ephrin signaling	18	8.34e-03	-0.359000	2.58e-02
Synthesis of PIPs at the late endosome membrane	11	3.93e-02	0.359000	8.82e-02
Host Interactions of HIV factors	118	1.75e-11	-0.358000	3.15e-10
Leishmania infection	213	1.90e-19	-0.358000	6.79e-18
Parasitic Infection Pathways	213	1.90e-19	-0.358000	6.79e-18
Regulation of localization of FOXO transcription factors	12	3.17e-02	-0.358000	7.52e-02
Translation of Structural Proteins 9683701	29	8.46e-04	-0.358000	3.80e-03
mRNA Capping	29	8.84e-04	-0.357000	3.93e-03
2-LTR circle formation	7	1.02e-01	-0.357000	1.92e-01
Downstream signaling events of B Cell Receptor (BCR)	68	3.69e-07	-0.356000	2.97e-06
Switching of origins to a post-replicative state	79	4.30e-08	-0.356000	3.94e-07
Cyclin A:Cdk2-associated events at S phase entry	75	9.97e-08	-0.356000	8.61e-07
Gap junction trafficking	28	1.13e-03	-0.356000	4.82e-03
PTK6 Regulates Cell Cycle	6	1.32e-01	-0.355000	2.33e-01
Fc epsilon receptor (FCERI) signaling	180	2.20e-16	-0.355000	5.97e-15
Estrogen-stimulated signaling through PRKCZ	6	1.34e-01	-0.353000	2.36e-01
Translesion Synthesis by POLH	18	9.50e-03	-0.353000	2.84e-02
Unwinding of DNA	12	3.46e-02	-0.352000	8.01e-02
RNA Polymerase III Transcription Termination	22	4.24e-03	-0.352000	1.48e-02
Cytoprotection by HMOX1	53	9.31e-06	-0.352000	6.16e-05
Biotin transport and metabolism	11	4.34e-02	-0.352000	9.60e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	6.61e-03	-0.351000	2.16e-02
Regulation of TLR by endogenous ligand	15	1.89e-02	-0.350000	4.96e-02
Cell surface interactions at the vascular wall	173	1.91e-15	-0.350000	4.71e-14
Hedgehog ‘on’ state	66	9.04e-07	-0.349000	6.94e-06
Cell-extracellular matrix interactions	15	1.93e-02	-0.349000	5.04e-02
RHO GTPases Activate NADPH Oxidases	22	4.61e-03	-0.349000	1.58e-02
Branched-chain ketoacid dehydrogenase kinase deficiency	5	1.78e-01	-0.348000	2.93e-01
Aflatoxin activation and detoxification	14	2.43e-02	-0.348000	6.03e-02
APC truncation mutants have impaired AXIN binding	14	2.44e-02	-0.347000	6.03e-02
AXIN missense mutants destabilize the destruction complex	14	2.44e-02	-0.347000	6.03e-02
Signaling by AMER1 mutants	14	2.44e-02	-0.347000	6.03e-02
Signaling by APC mutants	14	2.44e-02	-0.347000	6.03e-02
Signaling by AXIN mutants	14	2.44e-02	-0.347000	6.03e-02
Truncations of AMER1 destabilize the destruction complex	14	2.44e-02	-0.347000	6.03e-02
Removal of the Flap Intermediate from the C-strand	17	1.32e-02	-0.347000	3.70e-02
NADE modulates death signalling	5	1.79e-01	-0.347000	2.94e-01
Cellular responses to stress	697	4.46e-55	-0.346000	1.07e-52
Reactions specific to the complex N-glycan synthesis pathway	7	1.13e-01	-0.346000	2.08e-01
Nectin/Necl trans heterodimerization	5	1.81e-01	-0.346000	2.96e-01
Unfolded Protein Response (UPR)	85	3.64e-08	-0.345000	3.40e-07
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	3.83e-02	-0.345000	8.66e-02
alpha-linolenic acid (ALA) metabolism	12	3.83e-02	-0.345000	8.66e-02
TP53 Regulates Metabolic Genes	78	1.49e-07	-0.344000	1.25e-06
InlA-mediated entry of Listeria monocytogenes into host cells	9	7.46e-02	-0.343000	1.49e-01
Removal of the Flap Intermediate	14	2.62e-02	-0.343000	6.39e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	29	1.39e-03	-0.343000	5.82e-03
NFE2L2 regulates pentose phosphate pathway genes	8	9.34e-02	-0.343000	1.79e-01
Transcriptional regulation by RUNX2	89	2.42e-08	-0.342000	2.34e-07
Mitochondrial Fatty Acid Beta-Oxidation	36	3.84e-04	-0.342000	1.93e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	7.60e-02	-0.342000	1.51e-01
Eicosanoids	8	9.44e-02	0.341000	1.80e-01
ABC-family proteins mediated transport	81	1.08e-07	-0.341000	9.24e-07
Thyroxine biosynthesis	5	1.87e-01	0.341000	3.02e-01
Negative regulation of FGFR4 signaling	22	5.64e-03	-0.341000	1.87e-02
Downregulation of ERBB4 signaling	8	9.52e-02	-0.341000	1.81e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	3.55e-06	-0.340000	2.56e-05
Regulation of BACH1 activity	11	5.08e-02	-0.340000	1.09e-01
Downstream TCR signaling	89	2.91e-08	-0.340000	2.78e-07
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	3.40e-02	-0.340000	7.91e-02
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	51	2.72e-05	-0.340000	1.68e-04
Glutathione synthesis and recycling	10	6.38e-02	-0.339000	1.32e-01
DNA Replication	128	3.93e-11	-0.338000	6.48e-10
Base Excision Repair	57	1.04e-05	-0.337000	6.85e-05
Translesion synthesis by REV1	16	1.95e-02	-0.337000	5.07e-02
Negative regulation of FGFR3 signaling	21	7.44e-03	-0.337000	2.37e-02
Mitochondrial iron-sulfur cluster biogenesis	13	3.54e-02	-0.337000	8.16e-02
ChREBP activates metabolic gene expression	7	1.23e-01	-0.337000	2.22e-01
Cellular responses to stimuli	778	1.40e-57	-0.336000	4.48e-55
Cleavage of the damaged pyrimidine	27	2.51e-03	-0.336000	9.68e-03
Depyrimidination	27	2.51e-03	-0.336000	9.68e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	2.51e-03	-0.336000	9.68e-03
Glycosaminoglycan metabolism	98	9.02e-09	-0.336000	9.35e-08
Glycine degradation	7	1.24e-01	-0.335000	2.23e-01
G1/S Transition	120	2.30e-10	-0.335000	3.35e-09
Telomere Extension By Telomerase	23	5.49e-03	-0.334000	1.82e-02
Digestion	5	1.96e-01	0.334000	3.14e-01
PECAM1 interactions	12	4.50e-02	-0.334000	9.92e-02
APC/C:Cdc20 mediated degradation of Cyclin B	24	4.62e-03	-0.334000	1.58e-02
CLEC7A (Dectin-1) signaling	86	8.71e-08	-0.334000	7.63e-07
Formation of tubulin folding intermediates by CCT/TriC	21	8.22e-03	-0.333000	2.57e-02
Integration of provirus	9	8.35e-02	-0.333000	1.64e-01
Telomere Maintenance	78	3.75e-07	-0.333000	3.00e-06
Erythropoietin activates RAS	13	3.78e-02	-0.333000	8.59e-02
Apoptotic factor-mediated response	19	1.21e-02	-0.333000	3.43e-02
Chaperone Mediated Autophagy	20	1.00e-02	-0.333000	2.98e-02
Formation of apoptosome	11	5.62e-02	-0.332000	1.19e-01
Regulation of the apoptosome activity	11	5.62e-02	-0.332000	1.19e-01
Metabolism of carbohydrates	241	6.56e-19	-0.332000	2.22e-17
Protein folding	83	1.84e-07	-0.331000	1.52e-06
FGFR2 alternative splicing	25	4.24e-03	-0.330000	1.48e-02
Biosynthesis of E-series 18(S)-resolvins	5	2.01e-01	-0.330000	3.20e-01
Translesion synthesis by POLI	17	1.84e-02	-0.330000	4.85e-02
Association of TriC/CCT with target proteins during biosynthesis	35	7.25e-04	-0.330000	3.32e-03
Germ layer formation at gastrulation	9	8.68e-02	0.330000	1.69e-01
Synthesis of DNA	108	3.40e-09	-0.329000	3.77e-08
SARS-CoV-1 Infection	137	2.86e-11	-0.329000	4.97e-10
Activation of PUMA and translocation to mitochondria	9	8.75e-02	-0.329000	1.69e-01
TNFR2 non-canonical NF-kB pathway	84	1.94e-07	-0.328000	1.60e-06
Glutathione conjugation	27	3.16e-03	-0.328000	1.17e-02
Metabolism of cofactors	25	4.52e-03	-0.328000	1.56e-02
Inflammasomes	21	9.29e-03	-0.328000	2.79e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	3.37e-02	-0.328000	7.87e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	3.37e-02	-0.328000	7.87e-02
Ketone body metabolism	8	1.09e-01	-0.328000	2.02e-01
MyD88 deficiency (TLR2/4)	14	3.39e-02	-0.327000	7.89e-02
Viral Infection Pathways	775	1.78e-54	-0.327000	3.82e-52
RHO GTPases Activate WASPs and WAVEs	35	8.27e-04	-0.327000	3.72e-03
RSK activation	7	1.35e-01	-0.326000	2.37e-01
Incretin synthesis, secretion, and inactivation	14	3.46e-02	-0.326000	8.01e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	3.46e-02	-0.326000	8.01e-02
APOBEC3G mediated resistance to HIV-1 infection	5	2.07e-01	-0.326000	3.27e-01
Formation of axial mesoderm	6	1.67e-01	0.326000	2.79e-01
TBC/RABGAPs	45	1.55e-04	-0.326000	8.48e-04
Regulation of signaling by CBL	22	8.17e-03	-0.326000	2.56e-02
Attachment and Entry 9694614	15	2.90e-02	-0.326000	6.97e-02
Nucleotide catabolism	28	2.87e-03	-0.325000	1.08e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	1.36e-01	0.325000	2.39e-01
Maturation of hRSV A proteins	13	4.24e-02	-0.325000	9.45e-02
Regulation of TP53 Activity through Association with Co-factors	13	4.27e-02	-0.325000	9.49e-02
Linoleic acid (LA) metabolism	7	1.37e-01	-0.324000	2.41e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	5.98e-03	-0.324000	1.97e-02
Metabolic disorders of biological oxidation enzymes	23	7.13e-03	-0.324000	2.29e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	4.31e-02	-0.324000	9.56e-02
InlB-mediated entry of Listeria monocytogenes into host cell	12	5.26e-02	-0.323000	1.13e-01
CRMPs in Sema3A signaling	14	3.63e-02	-0.323000	8.31e-02
MAPK6/MAPK4 signaling	69	3.80e-06	-0.322000	2.71e-05
DNA Damage Reversal	8	1.15e-01	-0.322000	2.11e-01
Apoptosis induced DNA fragmentation	10	7.83e-02	-0.322000	1.55e-01
Transport and synthesis of PAPS	6	1.73e-01	-0.321000	2.86e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	2.18e-02	-0.321000	5.57e-02
Interleukin-1 signaling	99	3.40e-08	-0.321000	3.19e-07
RAS processing	23	7.72e-03	-0.321000	2.44e-02
Chaperonin-mediated protein folding	77	1.14e-06	-0.321000	8.62e-06
Keratan sulfate degradation	9	9.60e-02	-0.320000	1.82e-01
Cellular response to mitochondrial stress	9	9.69e-02	-0.320000	1.84e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.46e-06	-0.319000	1.08e-05
Activation of BH3-only proteins	30	2.49e-03	-0.319000	9.67e-03
Nef and signal transduction	8	1.19e-01	-0.318000	2.17e-01
ROS and RNS production in phagocytes	30	2.59e-03	-0.318000	9.94e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	3.65e-03	-0.317000	1.32e-02
MAP2K and MAPK activation	36	1.02e-03	-0.316000	4.41e-03
Gap junction trafficking and regulation	30	2.71e-03	-0.316000	1.03e-02
Cytochrome c-mediated apoptotic response	13	4.84e-02	-0.316000	1.05e-01
Phospholipase C-mediated cascade; FGFR2	8	1.23e-01	0.315000	2.22e-01
Glycosphingolipid metabolism	46	2.18e-04	-0.315000	1.14e-03
Regulation of PTEN localization	9	1.02e-01	-0.315000	1.92e-01
Role of ABL in ROBO-SLIT signaling	6	1.83e-01	-0.314000	2.98e-01
Vitamin B1 (thiamin) metabolism	5	2.25e-01	-0.314000	3.49e-01
G beta:gamma signalling through PLC beta	17	2.52e-02	-0.313000	6.22e-02
Presynaptic function of Kainate receptors	17	2.52e-02	-0.313000	6.22e-02
Regulation of PTEN gene transcription	59	3.16e-05	-0.313000	1.92e-04
TYSND1 cleaves peroxisomal proteins	7	1.52e-01	-0.313000	2.58e-01
Plasma lipoprotein assembly, remodeling, and clearance	55	6.03e-05	-0.313000	3.51e-04
E3 ubiquitin ligases ubiquitinate target proteins	51	1.14e-04	-0.312000	6.39e-04
Processive synthesis on the lagging strand	15	3.63e-02	-0.312000	8.31e-02
Infectious disease	958	2.41e-60	-0.312000	9.29e-58
rRNA processing in the mitochondrion	24	8.34e-03	-0.311000	2.58e-02
Intrinsic Pathway for Apoptosis	54	7.96e-05	-0.310000	4.57e-04
Transport of vitamins, nucleosides, and related molecules	31	2.81e-03	-0.310000	1.06e-02
Negative regulation of FGFR1 signaling	25	7.28e-03	-0.310000	2.33e-02
HIV Infection	213	6.00e-15	-0.310000	1.43e-13
MicroRNA (miRNA) biogenesis	24	8.65e-03	-0.310000	2.63e-02
Dual incision in TC-NER	63	2.14e-05	-0.310000	1.35e-04
PTEN Regulation	127	1.75e-09	-0.309000	2.05e-08
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	2.49e-03	-0.309000	9.67e-03
RHO GTPases activate IQGAPs	25	7.55e-03	-0.309000	2.39e-02
Respiratory syncytial virus (RSV) attachment and entry	19	1.99e-02	-0.309000	5.16e-02
Scavenging by Class F Receptors	5	2.33e-01	-0.308000	3.59e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	5.47e-02	-0.308000	1.17e-01
MAPK1 (ERK2) activation	9	1.11e-01	-0.307000	2.04e-01
Mitotic G1 phase and G1/S transition	138	4.75e-10	-0.307000	6.36e-09
Basigin interactions	21	1.50e-02	-0.307000	4.04e-02
Post-chaperonin tubulin folding pathway	18	2.43e-02	-0.307000	6.03e-02
Interaction between L1 and Ankyrins	27	6.01e-03	0.305000	1.98e-02
Recognition of DNA damage by PCNA-containing replication complex	30	3.79e-03	-0.305000	1.36e-02
Peroxisomal protein import	58	5.93e-05	-0.305000	3.46e-04
MTOR signalling	39	9.91e-04	-0.305000	4.34e-03
Transport of nucleotide sugars	9	1.13e-01	-0.305000	2.08e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	1.97e-01	0.304000	3.15e-01
Potential therapeutics for SARS	150	1.35e-10	-0.304000	2.12e-09
Cytosolic tRNA aminoacylation	24	1.01e-02	-0.303000	3.00e-02
Downregulation of ERBB2:ERBB3 signaling	12	6.89e-02	-0.303000	1.41e-01
Prolonged ERK activation events	13	5.91e-02	-0.302000	1.24e-01
Macroautophagy	128	3.64e-09	-0.302000	3.98e-08
Aggrephagy	34	2.32e-03	-0.302000	9.12e-03
Selective autophagy	77	4.69e-06	-0.302000	3.30e-05
FGFR3 ligand binding and activation	5	2.43e-01	0.301000	3.72e-01
FGFR3c ligand binding and activation	5	2.43e-01	0.301000	3.72e-01
SARS-CoV-2 Infection	267	2.41e-17	-0.301000	7.50e-16
Autophagy	142	6.01e-10	-0.301000	7.82e-09
Synthesis of glycosylphosphatidylinositol (GPI)	18	2.74e-02	-0.300000	6.62e-02
Reversible hydration of carbon dioxide	8	1.43e-01	0.299000	2.46e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	7.10e-03	-0.299000	2.29e-02
FGFR2c ligand binding and activation	5	2.47e-01	0.299000	3.77e-01
Signaling by high-kinase activity BRAF mutants	33	2.93e-03	-0.299000	1.10e-02
Senescence-Associated Secretory Phenotype (SASP)	65	3.02e-05	-0.299000	1.86e-04
Resolution of Abasic Sites (AP sites)	38	1.44e-03	-0.299000	6.02e-03
Nucleotide Excision Repair	108	8.07e-08	-0.299000	7.10e-07
Glycogen breakdown (glycogenolysis)	13	6.23e-02	-0.299000	1.30e-01
Calcitonin-like ligand receptors	5	2.48e-01	0.298000	3.78e-01
Innate Immune System	970	8.47e-56	-0.298000	2.33e-53
Activated NOTCH1 Transmits Signal to the Nucleus	27	7.48e-03	-0.297000	2.37e-02
Metabolism	1827	1.80e-99	-0.297000	3.44e-96
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	4.94e-03	-0.296000	1.67e-02
Acetylcholine binding and downstream events	5	2.51e-01	0.296000	3.81e-01
Postsynaptic nicotinic acetylcholine receptors	5	2.51e-01	0.296000	3.81e-01
Trafficking and processing of endosomal TLR	13	6.43e-02	-0.296000	1.33e-01
G2 Phase	5	2.52e-01	-0.296000	3.81e-01
RNA Polymerase I Promoter Escape	45	5.91e-04	-0.296000	2.79e-03
Diseases of programmed cell death	58	9.69e-05	-0.296000	5.49e-04
PIWI-interacting RNA (piRNA) biogenesis	23	1.41e-02	-0.296000	3.90e-02
Cation-coupled Chloride cotransporters	6	2.10e-01	0.296000	3.31e-01
Defensins	8	1.48e-01	-0.296000	2.52e-01
Metal ion SLC transporters	19	2.62e-02	-0.295000	6.39e-02
PCNA-Dependent Long Patch Base Excision Repair	21	1.95e-02	-0.294000	5.07e-02
Axon guidance	459	3.21e-27	-0.294000	1.47e-25
Defective pyroptosis	27	8.30e-03	-0.293000	2.58e-02
Beta-catenin independent WNT signaling	126	1.35e-08	-0.293000	1.36e-07
Regulation of TP53 Activity through Methylation	19	2.73e-02	-0.292000	6.62e-02
SARS-CoV Infections	434	1.43e-25	-0.292000	6.13e-24
Calcineurin activates NFAT	9	1.29e-01	-0.292000	2.29e-01
rRNA modification in the nucleus and cytosol	60	9.30e-05	-0.292000	5.29e-04
mRNA decay by 3’ to 5’ exoribonuclease	13	6.90e-02	-0.291000	1.41e-01
Alternative complement activation	5	2.59e-01	-0.291000	3.90e-01
Regulated proteolysis of p75NTR	11	9.47e-02	-0.291000	1.80e-01
Metabolism of proteins	1775	8.10e-93	-0.291000	7.81e-90
RNA Polymerase I Promoter Clearance	64	5.75e-05	-0.291000	3.38e-04
RNA Polymerase I Transcription	64	5.75e-05	-0.291000	3.38e-04
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.18e-01	-0.291000	3.40e-01
Suppression of apoptosis	7	1.84e-01	-0.290000	2.98e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	1.16e-04	-0.290000	6.51e-04
Nervous system development	478	1.57e-27	-0.290000	7.36e-26
activated TAK1 mediates p38 MAPK activation	23	1.62e-02	-0.290000	4.35e-02
TNFR1-mediated ceramide production	6	2.19e-01	-0.290000	3.43e-01
Recycling pathway of L1	40	1.56e-03	-0.289000	6.48e-03
Asparagine N-linked glycosylation	286	4.47e-17	-0.288000	1.35e-15
CD28 co-stimulation	33	4.21e-03	-0.288000	1.47e-02
Pre-NOTCH Processing in Golgi	18	3.47e-02	-0.288000	8.02e-02
Transcriptional regulation of brown and beige adipocyte differentiation	23	1.73e-02	-0.287000	4.58e-02
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	23	1.73e-02	-0.287000	4.58e-02
NoRC negatively regulates rRNA expression	60	1.23e-04	-0.287000	6.84e-04
ADP signalling through P2Y purinoceptor 1	21	2.30e-02	-0.286000	5.82e-02
Mitochondrial tRNA aminoacylation	21	2.31e-02	-0.286000	5.83e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	5.79e-06	-0.286000	4.00e-05
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	4.80e-02	-0.286000	1.04e-01
Synthesis of diphthamide-EEF2	8	1.63e-01	-0.285000	2.74e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.89e-02	-0.284000	1.06e-01
Platelet degranulation	105	4.77e-07	-0.284000	3.78e-06
CD28 dependent Vav1 pathway	12	8.85e-02	-0.284000	1.70e-01
Cargo recognition for clathrin-mediated endocytosis	87	4.83e-06	-0.284000	3.37e-05
Negative regulation of MAPK pathway	42	1.48e-03	-0.283000	6.17e-03
Voltage gated Potassium channels	27	1.09e-02	0.283000	3.19e-02
PRC2 methylates histones and DNA	27	1.11e-02	-0.282000	3.25e-02
CD163 mediating an anti-inflammatory response	9	1.43e-01	-0.282000	2.46e-01
Coenzyme A biosynthesis	7	1.96e-01	-0.282000	3.15e-01
tRNA Aminoacylation	42	1.60e-03	-0.281000	6.60e-03
Pyroptosis	25	1.49e-02	-0.281000	4.04e-02
Protein ubiquitination	71	4.22e-05	-0.281000	2.54e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	188	3.16e-11	-0.281000	5.39e-10
Thrombin signalling through proteinase activated receptors (PARs)	27	1.16e-02	-0.281000	3.34e-02
Metabolism of fat-soluble vitamins	28	1.02e-02	-0.281000	3.01e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.26e-01	-0.279000	2.25e-01
Transcriptional regulation of granulopoiesis	44	1.38e-03	-0.279000	5.80e-03
Triglyceride catabolism	15	6.22e-02	-0.278000	1.30e-01
Translesion synthesis by POLK	17	4.74e-02	-0.278000	1.03e-01
Interleukin-1 family signaling	127	6.43e-08	-0.278000	5.77e-07
Cholesterol biosynthesis	26	1.43e-02	-0.278000	3.94e-02
DNA replication initiation	8	1.75e-01	-0.277000	2.89e-01
Processing and activation of SUMO	10	1.30e-01	-0.277000	2.30e-01
Neddylation	216	2.44e-12	-0.276000	4.79e-11
TCR signaling	110	5.57e-07	-0.276000	4.40e-06
Zygotic genome activation (ZGA)	5	2.85e-01	0.276000	4.19e-01
Mitochondrial biogenesis	91	5.49e-06	-0.276000	3.81e-05
trans-Golgi Network Vesicle Budding	69	7.53e-05	-0.276000	4.35e-04
RUNX1 regulates expression of components of tight junctions	5	2.87e-01	0.275000	4.20e-01
Response to elevated platelet cytosolic Ca2+	109	7.25e-07	-0.275000	5.65e-06
Early Phase of HIV Life Cycle	14	7.53e-02	-0.275000	1.50e-01
COPI-independent Golgi-to-ER retrograde traffic	45	1.44e-03	-0.274000	6.03e-03
Processing of Capped Intronless Pre-mRNA	29	1.05e-02	-0.274000	3.11e-02
Synthesis, secretion, and deacylation of Ghrelin	11	1.15e-01	-0.274000	2.11e-01
VEGFR2 mediated vascular permeability	25	1.76e-02	-0.274000	4.67e-02
Uptake and function of anthrax toxins	11	1.16e-01	-0.273000	2.13e-01
Synthesis of 5-eicosatetraenoic acids	7	2.11e-01	-0.273000	3.32e-01
Prostacyclin signalling through prostacyclin receptor	16	5.88e-02	-0.273000	1.23e-01
tRNA modification in the mitochondrion	9	1.57e-01	-0.273000	2.65e-01
Cargo concentration in the ER	31	8.64e-03	-0.272000	2.63e-02
IRAK4 deficiency (TLR2/4)	15	6.80e-02	-0.272000	1.40e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	7.83e-02	-0.272000	1.55e-01
Negative epigenetic regulation of rRNA expression	63	1.93e-04	-0.271000	1.04e-03
VEGF binds to VEGFR leading to receptor dimerization	5	2.93e-01	-0.271000	4.25e-01
VEGF ligand-receptor interactions	5	2.93e-01	-0.271000	4.25e-01
RUNX2 regulates osteoblast differentiation	19	4.07e-02	-0.271000	9.11e-02
Activation of the pre-replicative complex	32	8.03e-03	-0.271000	2.52e-02
Metabolism of amine-derived hormones	10	1.39e-01	0.270000	2.42e-01
Oncogene Induced Senescence	33	7.25e-03	-0.270000	2.32e-02
Defective HLCS causes multiple carboxylase deficiency	7	2.16e-01	-0.270000	3.38e-01
FLT3 Signaling	38	4.02e-03	-0.270000	1.43e-02
Diseases associated with glycosylation precursor biosynthesis	15	7.08e-02	-0.269000	1.43e-01
SARS-CoV-2-host interactions	182	3.59e-10	-0.269000	5.08e-09
Signaling by NOTCH	173	1.04e-09	-0.269000	1.31e-08
Early SARS-CoV-2 Infection Events	32	8.53e-03	-0.269000	2.62e-02
Regulation of innate immune responses to cytosolic DNA	14	8.20e-02	-0.268000	1.61e-01
Butyrophilin (BTN) family interactions	10	1.42e-01	0.268000	2.45e-01
Chromatin modifications during the maternal to zygotic transition (MZT)	23	2.62e-02	-0.268000	6.39e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	4.31e-03	-0.268000	1.49e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	2.06e-02	-0.267000	5.31e-02
Synthesis of 12-eicosatetraenoic acid derivatives	6	2.57e-01	-0.267000	3.87e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.25e-01	-0.267000	2.23e-01
Positive epigenetic regulation of rRNA expression	60	3.43e-04	-0.267000	1.76e-03
IRAK2 mediated activation of TAK1 complex	10	1.43e-01	-0.267000	2.47e-01
G2/M Checkpoints	126	2.28e-07	-0.267000	1.84e-06
Sema3A PAK dependent Axon repulsion	16	6.46e-02	-0.267000	1.33e-01
ERK/MAPK targets	22	3.06e-02	-0.266000	7.27e-02
Pyruvate metabolism	44	2.28e-03	-0.266000	8.97e-03
Apoptosis	158	8.17e-09	-0.266000	8.55e-08
Trafficking of GluR2-containing AMPA receptors	11	1.27e-01	-0.266000	2.27e-01
TCF dependent signaling in response to WNT	152	1.64e-08	-0.265000	1.62e-07
GPER1 signaling	38	4.68e-03	-0.265000	1.59e-02
Processive synthesis on the C-strand of the telomere	19	4.61e-02	-0.264000	1.01e-01
Metabolism of RNA	717	1.75e-33	-0.264000	1.02e-31
PI-3K cascade:FGFR2	13	9.99e-02	0.264000	1.88e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	2.64e-01	-0.264000	3.95e-01
C-type lectin receptors (CLRs)	118	7.61e-07	-0.263000	5.91e-06
CD28 dependent PI3K/Akt signaling	22	3.25e-02	-0.263000	7.64e-02
Synthesis of PIPs at the early endosome membrane	16	6.82e-02	0.263000	1.40e-01
mRNA Editing	8	1.98e-01	0.263000	3.16e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	2.28e-01	-0.263000	3.53e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	6.87e-02	-0.263000	1.41e-01
Downregulation of ERBB2 signaling	24	2.59e-02	-0.263000	6.37e-02
Signaling by NTRK1 (TRKA)	102	4.63e-06	-0.262000	3.28e-05
Sphingolipid metabolism	92	1.36e-05	-0.262000	8.82e-05
MHC class II antigen presentation	113	1.47e-06	-0.262000	1.08e-05
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	4.79e-02	-0.262000	1.04e-01
Branched-chain amino acid catabolism	21	3.81e-02	-0.261000	8.64e-02
Na+/Cl- dependent neurotransmitter transporters	8	2.01e-01	0.261000	3.20e-01
Organic anion transporters	7	2.32e-01	-0.261000	3.58e-01
Transferrin endocytosis and recycling	26	2.13e-02	-0.261000	5.44e-02
Erythropoietin activates STAT5	6	2.68e-01	-0.261000	4.00e-01
Costimulation by the CD28 family	74	1.08e-04	-0.260000	6.10e-04
Cellular responses to mechanical stimuli	82	4.61e-05	-0.260000	2.75e-04
Response of endothelial cells to shear stress	82	4.61e-05	-0.260000	2.75e-04
Formation of RNA Pol II elongation complex	56	7.56e-04	-0.260000	3.44e-03
RNA Polymerase II Transcription Elongation	56	7.56e-04	-0.260000	3.44e-03
EPH-ephrin mediated repulsion of cells	43	3.18e-03	-0.260000	1.17e-02
DNA strand elongation	32	1.10e-02	-0.260000	3.21e-02
Activation of RAS in B cells	5	3.15e-01	0.260000	4.48e-01
APC-Cdc20 mediated degradation of Nek2A	26	2.21e-02	-0.259000	5.59e-02
Diseases of Mismatch Repair (MMR)	5	3.16e-01	0.259000	4.49e-01
Iron uptake and transport	52	1.24e-03	-0.259000	5.26e-03
Nuclear Events (kinase and transcription factor activation)	54	1.01e-03	-0.259000	4.39e-03
EPHB-mediated forward signaling	40	4.76e-03	-0.258000	1.61e-02
Protein methylation	15	8.40e-02	-0.258000	1.64e-01
Digestion and absorption	7	2.38e-01	0.258000	3.65e-01
SIRT1 negatively regulates rRNA expression	22	3.68e-02	-0.257000	8.40e-02
COPI-mediated anterograde transport	92	2.16e-05	-0.256000	1.36e-04
S Phase	150	6.27e-08	-0.256000	5.65e-07
HDACs deacetylate histones	45	3.00e-03	-0.256000	1.12e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	2.40e-02	-0.256000	6.02e-02
Hedgehog ‘off’ state	92	2.30e-05	-0.255000	1.44e-04
Diseases of Base Excision Repair	5	3.24e-01	-0.255000	4.59e-01
Assembly of active LPL and LIPC lipase complexes	10	1.64e-01	-0.254000	2.75e-01
Clathrin-mediated endocytosis	126	8.58e-07	-0.254000	6.61e-06
Signal amplification	28	2.02e-02	-0.254000	5.23e-02
Programmed Cell Death	187	2.26e-09	-0.253000	2.59e-08
G1/S-Specific Transcription	29	1.82e-02	-0.253000	4.80e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	7.97e-02	-0.253000	1.57e-01
DNA Damage/Telomere Stress Induced Senescence	42	4.55e-03	-0.253000	1.56e-02
RUNX2 regulates bone development	24	3.22e-02	-0.253000	7.62e-02
HIV Transcription Initiation	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II HIV Promoter Escape	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Promoter Escape	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Transcription Initiation	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	3.40e-03	-0.252000	1.23e-02
Initiation of Nuclear Envelope (NE) Reformation	19	5.78e-02	-0.251000	1.22e-01
Transcription of the HIV genome	67	3.73e-04	-0.251000	1.89e-03
Inactivation of CDC42 and RAC1	7	2.51e-01	-0.251000	3.80e-01
Glucagon signaling in metabolic regulation	26	2.71e-02	-0.250000	6.58e-02
Collagen biosynthesis and modifying enzymes	46	3.36e-03	-0.250000	1.23e-02
Depolymerization of the Nuclear Lamina	15	9.37e-02	-0.250000	1.79e-01
G beta:gamma signalling through PI3Kgamma	22	4.25e-02	-0.250000	9.45e-02
Type I hemidesmosome assembly	8	2.21e-01	-0.250000	3.45e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	2.53e-01	-0.250000	3.81e-01
Regulation of NF-kappa B signaling	18	6.67e-02	-0.250000	1.37e-01
NGF-stimulated transcription	32	1.45e-02	-0.250000	3.97e-02
Smooth Muscle Contraction	34	1.20e-02	-0.249000	3.41e-02
PD-1 signaling	28	2.27e-02	-0.249000	5.75e-02
Activation of the phototransduction cascade	9	1.97e-01	0.248000	3.15e-01
HSF1 activation	26	2.85e-02	-0.248000	6.86e-02
EPH-Ephrin signaling	81	1.13e-04	-0.248000	6.36e-04
B-WICH complex positively regulates rRNA expression	45	4.07e-03	-0.247000	1.43e-02
Termination of translesion DNA synthesis	32	1.54e-02	-0.247000	4.16e-02
COPII-mediated vesicle transport	67	4.71e-04	-0.247000	2.27e-03
Disease	1623	6.44e-62	-0.247000	3.10e-59
Assembly of the ORC complex at the origin of replication	23	4.11e-02	-0.246000	9.18e-02
Sperm Motility And Taxes	6	2.97e-01	0.246000	4.29e-01
Synthesis of substrates in N-glycan biosythesis	59	1.08e-03	-0.246000	4.65e-03
RAF-independent MAPK1/3 activation	22	4.61e-02	-0.246000	1.01e-01
Reelin signalling pathway	5	3.42e-01	0.245000	4.79e-01
Signaling by NODAL	15	1.00e-01	-0.245000	1.89e-01
RHO GTPases activate PKNs	46	4.03e-03	-0.245000	1.43e-02
MET receptor recycling	9	2.03e-01	-0.245000	3.23e-01
Reversal of alkylation damage by DNA dioxygenases	7	2.63e-01	-0.244000	3.94e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	1.12e-02	-0.244000	3.25e-02
Post-translational protein phosphorylation	67	5.43e-04	-0.244000	2.58e-03
AMPK inhibits chREBP transcriptional activation activity	6	3.00e-01	-0.244000	4.33e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.14e-01	-0.244000	2.09e-01
Signaling by FLT3 fusion proteins	18	7.32e-02	0.244000	1.47e-01
Signaling by Hedgehog	121	3.57e-06	-0.244000	2.56e-05
Activation of HOX genes during differentiation	70	4.28e-04	-0.243000	2.11e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	4.28e-04	-0.243000	2.11e-03
Transport to the Golgi and subsequent modification	171	4.14e-08	-0.243000	3.81e-07
Phase 0 - rapid depolarisation	24	3.96e-02	0.243000	8.88e-02
Heme degradation	10	1.84e-01	-0.243000	2.98e-01
Metabolism of porphyrins	22	4.89e-02	-0.243000	1.06e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	3.48e-01	-0.242000	4.84e-01
Activation of gene expression by SREBF (SREBP)	42	6.58e-03	-0.242000	2.15e-02
Regulation of TP53 Expression and Degradation	36	1.19e-02	-0.242000	3.39e-02
Transcriptional regulation by RUNX3	80	1.91e-04	-0.241000	1.03e-03
Alpha-oxidation of phytanate	6	3.07e-01	-0.241000	4.39e-01
Sphingolipid de novo biosynthesis	35	1.37e-02	-0.241000	3.80e-02
N-glycan antennae elongation in the medial/trans-Golgi	21	5.63e-02	-0.241000	1.19e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	3.93e-03	-0.241000	1.40e-02
Signaling by NTRKs	116	8.00e-06	-0.240000	5.37e-05
FGFR2 mutant receptor activation	23	4.68e-02	-0.240000	1.02e-01
Ribavirin ADME	11	1.69e-01	-0.239000	2.82e-01
Translocation of ZAP-70 to Immunological synapse	24	4.24e-02	-0.239000	9.45e-02
Extension of Telomeres	51	3.15e-03	-0.239000	1.17e-02
Signaling by ERBB2	44	6.22e-03	-0.238000	2.04e-02
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	3.12e-01	-0.238000	4.46e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	3.12e-01	-0.238000	4.46e-01
EGFR downregulation	26	3.56e-02	-0.238000	8.19e-02
Dual Incision in GG-NER	41	8.36e-03	-0.238000	2.58e-02
ER to Golgi Anterograde Transport	145	7.72e-07	-0.238000	5.97e-06
IL-6-type cytokine receptor ligand interactions	13	1.38e-01	0.238000	2.42e-01
ADP signalling through P2Y purinoceptor 12	18	8.11e-02	-0.237000	1.60e-01
Chromosome Maintenance	103	3.13e-05	-0.237000	1.91e-04
Transcriptional regulation by small RNAs	61	1.34e-03	-0.237000	5.67e-03
Glucose metabolism	76	3.56e-04	-0.237000	1.82e-03
DARPP-32 events	22	5.51e-02	-0.236000	1.17e-01
Vesicle-mediated transport	665	2.49e-25	-0.236000	1.04e-23
Golgi Associated Vesicle Biogenesis	55	2.47e-03	-0.236000	9.63e-03
Phosphorylation of the APC/C	20	6.79e-02	-0.236000	1.40e-01
Signalling to ERKs	32	2.10e-02	-0.236000	5.38e-02
Pyrimidine catabolism	9	2.21e-01	-0.236000	3.45e-01
p38MAPK events	13	1.42e-01	-0.235000	2.45e-01
Oxidative Stress Induced Senescence	77	3.54e-04	-0.235000	1.81e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	1.42e-01	-0.235000	2.46e-01
Signaling by NOTCH3	42	8.41e-03	-0.235000	2.59e-02
Recycling of eIF2:GDP	8	2.50e-01	-0.235000	3.80e-01
Regulation of TP53 Degradation	35	1.63e-02	-0.235000	4.37e-02
Signaling by VEGF	99	5.51e-05	-0.235000	3.28e-04
Endogenous sterols	17	9.45e-02	-0.234000	1.80e-01
Signaling by WNT	240	4.36e-10	-0.234000	5.88e-09
Activation of RAC1	11	1.80e-01	-0.234000	2.94e-01
Integrin signaling	22	5.80e-02	-0.233000	1.22e-01
Signaling by Retinoic Acid	29	2.96e-02	-0.233000	7.08e-02
Class I peroxisomal membrane protein import	20	7.08e-02	-0.233000	1.43e-01
Semaphorin interactions	57	2.33e-03	-0.233000	9.15e-03
Regulation of KIT signaling	15	1.18e-01	-0.233000	2.16e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	8.72e-02	-0.233000	1.69e-01
Synthesis of PC	23	5.33e-02	-0.233000	1.14e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	3.24e-01	-0.233000	4.58e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	76	4.62e-04	-0.232000	2.24e-03
Diseases of metabolism	204	1.14e-08	-0.232000	1.17e-07
Formation of Incision Complex in GG-NER	43	8.57e-03	-0.232000	2.62e-02
Nuclear events stimulated by ALK signaling in cancer	33	2.14e-02	-0.231000	5.45e-02
Retinoid metabolism and transport	25	4.54e-02	-0.231000	9.98e-02
Synaptic adhesion-like molecules	17	9.90e-02	-0.231000	1.87e-01
G-protein beta:gamma signalling	29	3.12e-02	-0.231000	7.42e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.64e-02	-0.231000	4.38e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	6.10e-02	-0.231000	1.28e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	3.81e-02	-0.231000	8.63e-02
Signaling by Insulin receptor	63	1.55e-03	-0.231000	6.43e-03
Disorders of transmembrane transporters	136	3.59e-06	-0.230000	2.57e-05
PIP3 activates AKT signaling	234	1.34e-09	-0.230000	1.62e-08
Glycolysis	68	1.07e-03	-0.229000	4.59e-03
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	1.69e-01	-0.229000	2.82e-01
Transport of connexons to the plasma membrane	12	1.69e-01	-0.229000	2.82e-01
Sensing of DNA Double Strand Breaks	6	3.32e-01	0.229000	4.66e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.38e-01	-0.229000	2.42e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	3.32e-02	-0.228000	7.77e-02
Platelet activation, signaling and aggregation	221	4.80e-09	-0.228000	5.14e-08
Hemostasis	558	3.78e-20	-0.227000	1.49e-18
Golgi-to-ER retrograde transport	123	1.33e-05	-0.227000	8.68e-05
Paracetamol ADME	19	8.63e-02	-0.227000	1.68e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	2.66e-01	-0.227000	3.98e-01
Chemokine receptors bind chemokines	41	1.19e-02	0.227000	3.39e-02
RHO GTPases Activate Rhotekin and Rhophilins	8	2.66e-01	-0.227000	3.98e-01
Proton-coupled monocarboxylate transport	6	3.36e-01	-0.227000	4.71e-01
Phosphate bond hydrolysis by NTPDase proteins	5	3.81e-01	-0.226000	5.16e-01
Signaling by WNT in cancer	30	3.23e-02	-0.226000	7.63e-02
Formation of definitive endoderm	9	2.41e-01	0.226000	3.69e-01
Signalling to RAS	19	8.85e-02	-0.226000	1.70e-01
Histidine catabolism	7	3.02e-01	-0.225000	4.35e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	1.45e-01	-0.225000	2.48e-01
MET activates PI3K/AKT signaling	5	3.84e-01	0.225000	5.19e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.30e-02	-0.224000	3.65e-02
Signaling by RAS mutants	41	1.30e-02	-0.224000	3.65e-02
Signaling by moderate kinase activity BRAF mutants	41	1.30e-02	-0.224000	3.65e-02
Signaling downstream of RAS mutants	41	1.30e-02	-0.224000	3.65e-02
VEGFA-VEGFR2 Pathway	92	2.12e-04	-0.223000	1.12e-03
eNOS activation	11	2.00e-01	-0.223000	3.20e-01
Listeria monocytogenes entry into host cells	17	1.11e-01	-0.223000	2.05e-01
Bacterial Infection Pathways	65	1.90e-03	-0.223000	7.65e-03
Signaling by FGFR2	61	2.63e-03	-0.223000	1.01e-02
Thromboxane signalling through TP receptor	20	8.52e-02	-0.222000	1.66e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	5.20e-03	-0.222000	1.74e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	5.20e-03	-0.222000	1.74e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	5.20e-03	-0.222000	1.74e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	5.20e-03	-0.222000	1.74e-02
Signaling by NOTCH1 in Cancer	53	5.20e-03	-0.222000	1.74e-02
PKA activation in glucagon signalling	14	1.51e-01	-0.221000	2.58e-01
Regulation of TP53 Activity through Acetylation	29	3.90e-02	-0.221000	8.77e-02
Recycling of bile acids and salts	10	2.25e-01	0.221000	3.49e-01
Synthesis of IP3 and IP4 in the cytosol	22	7.22e-02	-0.221000	1.46e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	4.53e-03	-0.221000	1.56e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	9.99e-04	-0.221000	4.36e-03
Adaptive Immune System	771	1.36e-25	-0.221000	5.94e-24
HIV Life Cycle	144	4.66e-06	-0.221000	3.29e-05
Metabolism of nitric oxide: NOS3 activation and regulation	14	1.52e-01	-0.221000	2.59e-01
DNA Damage Bypass	47	8.81e-03	-0.221000	2.67e-02
Interleukin-12 signaling	44	1.13e-02	-0.221000	3.27e-02
Interleukin-17 signaling	68	1.65e-03	-0.221000	6.77e-03
RNA Polymerase III Transcription Initiation	36	2.20e-02	-0.221000	5.58e-02
Biosynthesis of maresins	6	3.50e-01	0.220000	4.84e-01
DNA Double Strand Break Response	47	8.97e-03	-0.220000	2.71e-02
Defects in biotin (Btn) metabolism	8	2.82e-01	-0.220000	4.17e-01
MAP kinase activation	63	2.59e-03	-0.219000	9.94e-03
Other semaphorin interactions	16	1.29e-01	-0.219000	2.29e-01
Late Phase of HIV Life Cycle	131	1.50e-05	-0.219000	9.70e-05
Mitotic Prophase	96	2.12e-04	-0.219000	1.12e-03
Condensation of Prometaphase Chromosomes	11	2.10e-01	-0.218000	3.31e-01
Cellular Senescence	143	6.49e-06	-0.218000	4.46e-05
CDC6 association with the ORC:origin complex	8	2.85e-01	0.218000	4.19e-01
Regulation of pyruvate metabolism	32	3.28e-02	-0.218000	7.68e-02
Glucagon-type ligand receptors	20	9.17e-02	-0.218000	1.75e-01
Vitamin D (calciferol) metabolism	11	2.12e-01	-0.217000	3.33e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	2.14e-01	-0.217000	3.35e-01
RNA Polymerase III Abortive And Retractive Initiation	40	1.78e-02	-0.216000	4.71e-02
RNA Polymerase III Transcription	40	1.78e-02	-0.216000	4.71e-02
Syndecan interactions	25	6.16e-02	-0.216000	1.28e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	1.13e-02	-0.216000	3.27e-02
Cross-presentation of particulate exogenous antigens (phagosomes)	8	2.91e-01	-0.216000	4.24e-01
Mitotic Anaphase	211	6.78e-08	-0.215000	6.05e-07
Intracellular signaling by second messengers	267	1.35e-09	-0.215000	1.63e-08
Regulation of FZD by ubiquitination	16	1.36e-01	-0.215000	2.39e-01
TNFs bind their physiological receptors	25	6.32e-02	-0.215000	1.31e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	1.52e-01	-0.214000	2.58e-01
Signaling by Activin	13	1.82e-01	-0.214000	2.97e-01
Sema4D in semaphorin signaling	22	8.26e-02	-0.214000	1.62e-01
Phase II - Conjugation of compounds	70	2.03e-03	-0.213000	8.08e-03
Class I MHC mediated antigen processing & presentation	345	1.05e-11	-0.213000	1.95e-10
Mismatch Repair	15	1.53e-01	-0.213000	2.60e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.29e-01	-0.213000	2.29e-01
RNA Polymerase I Transcription Initiation	47	1.16e-02	-0.213000	3.34e-02
Impaired BRCA2 binding to PALB2	24	7.15e-02	0.213000	1.44e-01
Mitotic Metaphase and Anaphase	212	1.02e-07	-0.212000	8.73e-07
G beta:gamma signalling through CDC42	17	1.30e-01	-0.212000	2.31e-01
Regulation of signaling by NODAL	6	3.69e-01	-0.212000	5.05e-01
Separation of Sister Chromatids	168	2.16e-06	-0.212000	1.58e-05
Carboxyterminal post-translational modifications of tubulin	34	3.26e-02	-0.212000	7.65e-02
Interleukin-2 signaling	11	2.24e-01	-0.212000	3.48e-01
Negative regulation of FGFR2 signaling	24	7.30e-02	-0.211000	1.47e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	9	2.72e-01	-0.211000	4.04e-01
Pre-NOTCH Expression and Processing	63	3.71e-03	-0.211000	1.33e-02
Telomere C-strand synthesis initiation	13	1.87e-01	-0.211000	3.03e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	1.50e-04	-0.211000	8.19e-04
Toll Like Receptor TLR6:TLR2 Cascade	108	1.50e-04	-0.211000	8.19e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	1.88e-01	-0.211000	3.03e-01
ADORA2B mediated anti-inflammatory cytokines production	36	2.85e-02	-0.211000	6.86e-02
mRNA Splicing - Major Pathway	203	2.19e-07	-0.211000	1.78e-06
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	8.03e-02	-0.211000	1.58e-01
Signaling by FGFR	73	1.95e-03	-0.210000	7.82e-03
Post-translational protein modification	1245	1.22e-35	-0.210000	8.08e-34
Interleukin-1 processing	8	3.05e-01	-0.209000	4.38e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	6.22e-07	-0.209000	4.90e-06
HCMV Late Events	67	3.09e-03	-0.209000	1.15e-02
Transcriptional Regulation by TP53	346	2.35e-11	-0.209000	4.15e-10
Cardiogenesis	14	1.76e-01	-0.209000	2.91e-01
Metabolism of vitamins and cofactors	167	3.30e-06	-0.209000	2.39e-05
Molybdenum cofactor biosynthesis	6	3.77e-01	-0.208000	5.13e-01
Gastrulation	76	1.69e-03	-0.208000	6.87e-03
mRNA decay by 5’ to 3’ exoribonuclease	15	1.63e-01	-0.208000	2.74e-01
Platelet homeostasis	69	2.89e-03	-0.207000	1.09e-02
Bicarbonate transporters	9	2.83e-01	0.207000	4.17e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	8.69e-02	-0.206000	1.69e-01
Toll Like Receptor 2 (TLR2) Cascade	109	2.03e-04	-0.206000	1.08e-03
Toll Like Receptor TLR1:TLR2 Cascade	109	2.03e-04	-0.206000	1.08e-03
Defective GALNT3 causes HFTC	9	2.86e-01	0.205000	4.19e-01
Formation of the cornified envelope	37	3.13e-02	-0.205000	7.43e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	3.49e-01	-0.204000	4.84e-01
Regulation of CDH11 gene transcription	5	4.29e-01	-0.204000	5.64e-01
Lagging Strand Synthesis	20	1.14e-01	-0.204000	2.10e-01
RUNX1 regulates estrogen receptor mediated transcription	6	3.87e-01	0.204000	5.21e-01
TP53 Regulates Transcription of DNA Repair Genes	61	5.90e-03	-0.204000	1.95e-02
Diseases of branched-chain amino acid catabolism	13	2.03e-01	-0.204000	3.23e-01
PI3K/AKT activation	8	3.18e-01	-0.204000	4.52e-01
Signaling by Receptor Tyrosine Kinases	443	1.98e-13	-0.204000	4.24e-12
COPI-dependent Golgi-to-ER retrograde traffic	90	8.56e-04	-0.203000	3.84e-03
Developmental Biology	924	1.11e-25	-0.203000	4.98e-24
Peroxisomal lipid metabolism	27	6.78e-02	-0.203000	1.40e-01
Interleukin-18 signaling	6	3.89e-01	-0.203000	5.23e-01
Miro GTPase Cycle	8	3.21e-01	-0.203000	4.55e-01
Immune System	1841	3.01e-47	-0.203000	5.80e-45
Interleukin-12 family signaling	53	1.08e-02	-0.202000	3.18e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	6.89e-02	-0.202000	1.41e-01
CREB3 factors activate genes	6	3.91e-01	-0.202000	5.24e-01
mRNA Splicing	211	4.41e-07	-0.202000	3.51e-06
RND2 GTPase cycle	36	3.64e-02	-0.201000	8.33e-02
RA biosynthesis pathway	13	2.09e-01	-0.201000	3.29e-01
Acetylcholine regulates insulin secretion	9	2.96e-01	-0.201000	4.28e-01
Glycerophospholipid biosynthesis	105	3.67e-04	-0.201000	1.86e-03
Diseases of glycosylation	110	2.67e-04	-0.201000	1.39e-03
AKT phosphorylates targets in the cytosol	14	1.94e-01	-0.201000	3.11e-01
Polymerase switching on the C-strand of the telomere	26	7.67e-02	-0.201000	1.52e-01
Transcriptional regulation by RUNX1	170	6.73e-06	-0.200000	4.61e-05
RNA Polymerase II Pre-transcription Events	77	2.43e-03	-0.200000	9.51e-03
VEGFR2 mediated cell proliferation	18	1.43e-01	-0.199000	2.46e-01
Lipophagy	7	3.63e-01	-0.199000	5.00e-01
Membrane Trafficking	574	3.93e-16	-0.199000	1.02e-14
Signaling by RAF1 mutants	37	3.66e-02	-0.199000	8.35e-02
IRF3-mediated induction of type I IFN	12	2.34e-01	-0.199000	3.59e-01
GPVI-mediated activation cascade	32	5.23e-02	-0.198000	1.12e-01
HCMV Infection	106	4.27e-04	-0.198000	2.11e-03
Free fatty acids regulate insulin secretion	10	2.78e-01	-0.198000	4.12e-01
G beta:gamma signalling through BTK	15	1.85e-01	-0.198000	3.00e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	5.69e-02	-0.198000	1.20e-01
RNA Polymerase II Transcription Termination	66	5.52e-03	-0.198000	1.83e-02
Meiotic recombination	37	3.78e-02	-0.197000	8.59e-02
Urea cycle	7	3.66e-01	-0.197000	5.04e-01
Keratan sulfate/keratin metabolism	28	7.08e-02	-0.197000	1.43e-01
Interleukin-21 signaling	9	3.06e-01	0.197000	4.39e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	4.71e-02	-0.197000	1.03e-01
p75 NTR receptor-mediated signalling	89	1.34e-03	-0.197000	5.66e-03
RNA Polymerase I Transcription Termination	30	6.23e-02	-0.197000	1.30e-01
Gap junction assembly	17	1.61e-01	-0.196000	2.71e-01
AKT phosphorylates targets in the nucleus	10	2.83e-01	-0.196000	4.17e-01
RAB geranylgeranylation	63	7.29e-03	-0.195000	2.33e-02
Collagen formation	64	6.86e-03	-0.195000	2.23e-02
Signaling by NOTCH1	66	6.05e-03	-0.195000	1.99e-02
Nuclear Envelope (NE) Reassembly	68	5.42e-03	-0.195000	1.80e-02
Organic cation transport	8	3.40e-01	0.195000	4.76e-01
Organic cation/anion/zwitterion transport	8	3.40e-01	0.195000	4.76e-01
HATs acetylate histones	92	1.30e-03	-0.194000	5.53e-03
FOXO-mediated transcription of cell death genes	16	1.80e-01	-0.194000	2.95e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	3.15e-01	-0.193000	4.48e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	3.76e-01	-0.193000	5.13e-01
ERBB2 Regulates Cell Motility	10	2.91e-01	-0.193000	4.24e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.70e-01	-0.192000	2.82e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.70e-01	-0.192000	2.82e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.83e-01	-0.192000	2.98e-01
Constitutive Signaling by Overexpressed ERBB2	11	2.70e-01	-0.192000	4.02e-01
Meiotic synapsis	43	2.97e-02	-0.192000	7.08e-02
Fatty acid metabolism	157	3.48e-05	-0.191000	2.11e-04
Evasion by RSV of host interferon responses	20	1.39e-01	-0.191000	2.42e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	1.34e-02	-0.191000	3.74e-02
Uptake of dietary cobalamins into enterocytes	6	4.18e-01	0.191000	5.52e-01
Rab regulation of trafficking	121	2.91e-04	-0.191000	1.51e-03
Activation of the TFAP2 (AP-2) family of transcription factors	7	3.83e-01	-0.190000	5.19e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	1.22e-01	-0.190000	2.22e-01
Cyclin D associated events in G1	47	2.40e-02	-0.190000	6.02e-02
G1 Phase	47	2.40e-02	-0.190000	6.02e-02
NOTCH1 Intracellular Domain Regulates Transcription	44	2.91e-02	-0.190000	6.98e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	1.04e-03	-0.190000	4.47e-03
ALK mutants bind TKIs	11	2.76e-01	0.190000	4.10e-01
SMAC (DIABLO) binds to IAPs	7	3.86e-01	-0.189000	5.20e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	3.86e-01	-0.189000	5.20e-01
SMAC, XIAP-regulated apoptotic response	7	3.86e-01	-0.189000	5.20e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	8.24e-04	-0.189000	3.72e-03
Retrograde transport at the Trans-Golgi-Network	49	2.23e-02	-0.189000	5.65e-02
Signaling by Non-Receptor Tyrosine Kinases	47	2.54e-02	-0.188000	6.25e-02
Signaling by PTK6	47	2.54e-02	-0.188000	6.25e-02
Phase 4 - resting membrane potential	9	3.28e-01	-0.188000	4.63e-01
Transcriptional regulation of testis differentiation	5	4.66e-01	0.188000	5.94e-01
Purine salvage	12	2.59e-01	-0.188000	3.90e-01
Signaling by Nuclear Receptors	210	2.66e-06	-0.188000	1.94e-05
Antigen processing: Ubiquitination & Proteasome degradation	276	8.01e-08	-0.188000	7.08e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	1.09e-02	-0.187000	3.19e-02
MyD88 dependent cascade initiated on endosome	101	1.20e-03	-0.187000	5.10e-03
MyD88 cascade initiated on plasma membrane	95	1.68e-03	-0.186000	6.85e-03
Toll Like Receptor 10 (TLR10) Cascade	95	1.68e-03	-0.186000	6.85e-03
Toll Like Receptor 5 (TLR5) Cascade	95	1.68e-03	-0.186000	6.85e-03
MAPK1/MAPK3 signaling	231	1.16e-06	-0.186000	8.80e-06
Biological oxidations	143	1.29e-04	-0.185000	7.12e-04
PKA activation	15	2.14e-01	-0.185000	3.35e-01
RHO GTPase Effectors	259	2.82e-07	-0.185000	2.28e-06
Phosphorylation of CD3 and TCR zeta chains	27	9.58e-02	-0.185000	1.82e-01
Mitotic G2-G2/M phases	179	1.94e-05	-0.185000	1.24e-04
rRNA modification in the mitochondrion	8	3.65e-01	-0.185000	5.03e-01
Metabolism of steroid hormones	21	1.43e-01	-0.185000	2.46e-01
Signaling by FGFR4	32	7.09e-02	-0.184000	1.43e-01
Telomere C-strand (Lagging Strand) Synthesis	34	6.27e-02	-0.184000	1.30e-01
Regulation of HMOX1 expression and activity	5	4.76e-01	-0.184000	6.04e-01
Metabolism of Angiotensinogen to Angiotensins	12	2.71e-01	-0.184000	4.02e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	1.78e-01	-0.184000	2.92e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	2.52e-01	-0.184000	3.81e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	3.52e-02	-0.184000	8.11e-02
Diseases of signal transduction by growth factor receptors and second messengers	401	3.12e-10	-0.183000	4.46e-09
Activation of kainate receptors upon glutamate binding	26	1.07e-01	-0.183000	1.99e-01
Transcriptional regulation of pluripotent stem cells	19	1.69e-01	0.182000	2.82e-01
Post-translational modification: synthesis of GPI-anchored proteins	60	1.47e-02	-0.182000	4.00e-02
Defective LFNG causes SCDO3	5	4.81e-01	-0.182000	6.08e-01
Signaling by BRAF and RAF1 fusions	60	1.49e-02	-0.182000	4.04e-02
G2/M Transition	177	3.07e-05	-0.182000	1.88e-04
DNA Repair	289	1.09e-07	-0.182000	9.33e-07
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	4.41e-01	-0.181000	5.74e-01
FRS-mediated FGFR2 signaling	15	2.24e-01	0.181000	3.48e-01
Heme biosynthesis	13	2.58e-01	-0.181000	3.88e-01
Regulation of CDH11 mRNA translation by microRNAs	8	3.76e-01	0.181000	5.12e-01
Regulation of NPAS4 mRNA translation	8	3.76e-01	0.181000	5.12e-01
Pre-NOTCH Transcription and Translation	47	3.29e-02	-0.180000	7.71e-02
OAS antiviral response	8	3.79e-01	0.180000	5.15e-01
Generation of second messenger molecules	38	5.57e-02	-0.179000	1.18e-01
Cell Cycle Checkpoints	246	1.36e-06	-0.179000	1.01e-05
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	9	3.53e-01	-0.179000	4.88e-01
Signaling by FGFR3 in disease	14	2.47e-01	0.179000	3.77e-01
RAF/MAP kinase cascade	225	3.94e-06	-0.179000	2.80e-05
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	1.24e-01	0.178000	2.22e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	1.24e-01	0.178000	2.22e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	1.24e-01	0.178000	2.22e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	1.24e-01	0.178000	2.22e-01
IFNG signaling activates MAPKs	8	3.84e-01	-0.178000	5.19e-01
Notch-HLH transcription pathway	28	1.04e-01	-0.177000	1.95e-01
Keratinization	38	5.84e-02	-0.177000	1.23e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	1.81e-01	-0.177000	2.96e-01
Signal regulatory protein family interactions	13	2.69e-01	-0.177000	4.01e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.61e-01	-0.177000	2.70e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.61e-01	-0.177000	2.70e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	4.54e-01	0.177000	5.84e-01
SUMOylation of transcription factors	16	2.22e-01	-0.176000	3.45e-01
Negative regulators of DDX58/IFIH1 signaling	34	7.60e-02	-0.176000	1.51e-01
Disorders of Developmental Biology	12	2.92e-01	-0.176000	4.24e-01
Disorders of Nervous System Development	12	2.92e-01	-0.176000	4.24e-01
Loss of function of MECP2 in Rett syndrome	12	2.92e-01	-0.176000	4.24e-01
Pervasive developmental disorders	12	2.92e-01	-0.176000	4.24e-01
Ub-specific processing proteases	153	1.81e-04	-0.175000	9.79e-04
Cytosolic sensors of pathogen-associated DNA	63	1.62e-02	-0.175000	4.35e-02
RHOT2 GTPase cycle	7	4.23e-01	-0.175000	5.57e-01
M Phase	346	2.29e-08	-0.175000	2.23e-07
Signaling by FGFR1	42	5.02e-02	-0.175000	1.08e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	2.01e-01	-0.174000	3.20e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	2.01e-01	-0.174000	3.20e-01
Role of second messengers in netrin-1 signaling	6	4.61e-01	-0.174000	5.90e-01
G0 and Early G1	27	1.18e-01	-0.174000	2.16e-01
Carnitine shuttle	12	3.00e-01	-0.173000	4.33e-01
Uptake and function of diphtheria toxin	6	4.64e-01	-0.173000	5.94e-01
G alpha (z) signalling events	36	7.34e-02	-0.172000	1.47e-01
Other interleukin signaling	19	1.94e-01	-0.172000	3.12e-01
Viral Messenger RNA Synthesis	44	4.84e-02	-0.172000	1.05e-01
RAF activation	33	8.73e-02	-0.172000	1.69e-01
Regulated Necrosis	56	2.61e-02	-0.172000	6.39e-02
FGFR1b ligand binding and activation	5	5.06e-01	-0.172000	6.30e-01
Metabolism of steroids	123	1.01e-03	-0.172000	4.39e-03
Neurofascin interactions	5	5.06e-01	0.172000	6.30e-01
RHOH GTPase cycle	33	8.83e-02	-0.171000	1.70e-01
Formation of the active cofactor, UDP-glucuronate	5	5.09e-01	-0.171000	6.32e-01
Ovarian tumor domain proteases	37	7.24e-02	-0.171000	1.46e-01
Common Pathway of Fibrin Clot Formation	13	2.87e-01	-0.171000	4.20e-01
Mitochondrial RNA degradation	25	1.40e-01	-0.171000	2.43e-01
Fanconi Anemia Pathway	36	7.67e-02	-0.170000	1.52e-01
Triglyceride metabolism	24	1.50e-01	-0.170000	2.55e-01
ESR-mediated signaling	157	2.40e-04	-0.170000	1.25e-03
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	3.31e-01	0.169000	4.66e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	1.09e-01	-0.169000	2.02e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	3.10e-01	-0.169000	4.44e-01
Downstream signaling of activated FGFR2	20	1.91e-01	0.169000	3.07e-01
E2F mediated regulation of DNA replication	22	1.70e-01	-0.169000	2.82e-01
Signaling by EGFR in Cancer	22	1.70e-01	-0.169000	2.82e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.20e-06	-0.169000	9.00e-06
Transport of small molecules	556	9.95e-12	-0.169000	1.86e-10
Antimicrobial peptides	34	8.86e-02	-0.169000	1.70e-01
Toll Like Receptor 4 (TLR4) Cascade	138	6.25e-04	-0.169000	2.94e-03
G-protein activation	19	2.04e-01	-0.168000	3.23e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	4.41e-01	-0.168000	5.74e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.24e-01	-0.168000	2.22e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	1.47e-01	-0.168000	2.51e-01
Toll-like Receptor Cascades	162	2.38e-04	-0.167000	1.24e-03
Reduction of cytosolic Ca++ levels	9	3.85e-01	-0.167000	5.20e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	3.16e-01	-0.167000	4.49e-01
Activated NTRK2 signals through RAS	6	4.78e-01	-0.167000	6.05e-01
Activated NTRK3 signals through RAS	6	4.78e-01	-0.167000	6.05e-01
Toll Like Receptor 9 (TLR9) Cascade	108	2.71e-03	-0.167000	1.03e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.34e-01	-0.167000	3.59e-01
RUNX3 regulates NOTCH signaling	14	2.82e-01	-0.166000	4.17e-01
SLC15A4:TASL-dependent IRF5 activation	6	4.82e-01	-0.166000	6.09e-01
Nucleotide-like (purinergic) receptors	14	2.83e-01	-0.166000	4.17e-01
Cell Cycle, Mitotic	488	4.13e-10	-0.165000	5.64e-09
Respiratory Syncytial Virus Infection Pathway	99	4.53e-03	-0.165000	1.56e-02
Response of EIF2AK1 (HRI) to heme deficiency	14	2.85e-01	-0.165000	4.19e-01
Deadenylation-dependent mRNA decay	50	4.36e-02	-0.165000	9.64e-02
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	8.58e-03	-0.165000	2.62e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	8.58e-03	-0.165000	2.62e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	8.58e-03	-0.165000	2.62e-02
RHOG GTPase cycle	70	1.71e-02	-0.165000	4.55e-02
Regulation of TP53 Activity	153	4.45e-04	-0.164000	2.18e-03
Metabolism of water-soluble vitamins and cofactors	116	2.22e-03	-0.164000	8.78e-03
Specification of primordial germ cells	6	4.86e-01	0.164000	6.13e-01
Erythrocytes take up carbon dioxide and release oxygen	11	3.47e-01	0.164000	4.84e-01
O2/CO2 exchange in erythrocytes	11	3.47e-01	0.164000	4.84e-01
Post-transcriptional silencing by small RNAs	7	4.54e-01	0.163000	5.84e-01
CASP8 activity is inhibited	11	3.49e-01	0.163000	4.84e-01
Dimerization of procaspase-8	11	3.49e-01	0.163000	4.84e-01
Regulation by c-FLIP	11	3.49e-01	0.163000	4.84e-01
RHOQ GTPase cycle	54	3.88e-02	-0.163000	8.73e-02
Deubiquitination	225	2.68e-05	-0.162000	1.66e-04
Polo-like kinase mediated events	16	2.61e-01	-0.162000	3.92e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.99e-02	-0.162000	5.16e-02
PI3K events in ERBB4 signaling	6	4.93e-01	0.162000	6.19e-01
Sodium/Calcium exchangers	9	4.02e-01	-0.161000	5.35e-01
Maturation of protein 3a 9683673	9	4.02e-01	-0.161000	5.35e-01
Maturation of protein 3a 9694719	9	4.02e-01	-0.161000	5.35e-01
Creatine metabolism	6	4.94e-01	0.161000	6.20e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	3.55e-01	0.161000	4.90e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.48e-01	0.161000	2.53e-01
Platelet calcium homeostasis	22	1.92e-01	-0.161000	3.10e-01
Neurotoxicity of clostridium toxins	8	4.32e-01	0.160000	5.67e-01
RAB GEFs exchange GTP for GDP on RABs	88	9.33e-03	-0.160000	2.79e-02
SARS-CoV-1 activates/modulates innate immune responses	40	8.00e-02	-0.160000	1.58e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	3.01e-01	-0.160000	4.34e-01
MAPK family signaling cascades	263	8.47e-06	-0.159000	5.67e-05
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	9.80e-02	-0.159000	1.86e-01
TGF-beta receptor signaling activates SMADs	45	6.44e-02	-0.159000	1.33e-01
Anchoring fibril formation	8	4.38e-01	-0.158000	5.73e-01
Gene Silencing by RNA	87	1.13e-02	-0.157000	3.27e-02
RUNX3 Regulates Immune Response and Cell Migration	5	5.44e-01	-0.157000	6.69e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	4.43e-01	-0.157000	5.74e-01
Opioid Signalling	75	1.90e-02	-0.157000	4.97e-02
CDH11 homotypic and heterotypic interactions	5	5.44e-01	-0.157000	6.70e-01
Intra-Golgi traffic	43	7.61e-02	-0.156000	1.51e-01
Synthesis of PE	12	3.49e-01	-0.156000	4.84e-01
G alpha (s) signalling events	96	8.24e-03	-0.156000	2.57e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	3.49e-01	-0.156000	4.84e-01
Inositol phosphate metabolism	42	8.02e-02	-0.156000	1.58e-01
Elevation of cytosolic Ca2+ levels	13	3.31e-01	-0.156000	4.66e-01
Erythropoietin activates Phospholipase C gamma (PLCG)	6	5.09e-01	-0.156000	6.32e-01
Methylation	13	3.32e-01	-0.155000	4.66e-01
Diseases associated with surfactant metabolism	5	5.48e-01	0.155000	6.72e-01
Cohesin Loading onto Chromatin	10	3.95e-01	0.155000	5.27e-01
Maturation of nucleoprotein 9683610	11	3.73e-01	-0.155000	5.10e-01
Drug ADME	57	4.28e-02	-0.155000	9.50e-02
Signaling by Interleukins	390	1.48e-07	-0.155000	1.24e-06
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	4.22e-01	-0.155000	5.56e-01
Receptor-type tyrosine-protein phosphatases	11	3.75e-01	0.154000	5.12e-01
PKA-mediated phosphorylation of CREB	17	2.71e-01	-0.154000	4.02e-01
Ras activation upon Ca2+ influx through NMDA receptor	18	2.57e-01	0.154000	3.87e-01
Estrogen-dependent gene expression	96	9.03e-03	-0.154000	2.73e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.33e-01	-0.154000	3.58e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	37	1.05e-01	-0.154000	1.97e-01
Downregulation of TGF-beta receptor signaling	26	1.75e-01	-0.154000	2.89e-01
Metabolism of lipids	641	3.44e-11	-0.153000	5.82e-10
Cell Cycle	611	9.61e-11	-0.153000	1.53e-09
NPAS4 regulates expression of target genes	16	2.89e-01	-0.153000	4.22e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	5	5.53e-01	0.153000	6.77e-01
Transcriptional Regulation by E2F6	34	1.23e-01	-0.153000	2.22e-01
Sema4D induced cell migration and growth-cone collapse	19	2.49e-01	-0.153000	3.79e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	3.06e-01	-0.153000	4.39e-01
Diseases associated with the TLR signaling cascade	29	1.56e-01	-0.152000	2.64e-01
Diseases of Immune System	29	1.56e-01	-0.152000	2.64e-01
tRNA processing	128	2.94e-03	-0.152000	1.10e-02
TAK1-dependent IKK and NF-kappa-B activation	43	8.43e-02	-0.152000	1.65e-01
Oncogenic MAPK signaling	76	2.20e-02	-0.152000	5.59e-02
Signaling by MET	68	3.05e-02	-0.152000	7.26e-02
DNA Double-Strand Break Repair	137	2.17e-03	-0.152000	8.59e-03
ATF4 activates genes in response to endoplasmic reticulum stress	26	1.81e-01	-0.151000	2.96e-01
RHOT1 GTPase cycle	5	5.58e-01	-0.151000	6.81e-01
Interleukin-27 signaling	11	3.85e-01	-0.151000	5.20e-01
PERK regulates gene expression	31	1.46e-01	-0.151000	2.50e-01
Signaling by PDGFR in disease	19	2.56e-01	0.151000	3.85e-01
SUMOylation of intracellular receptors	26	1.84e-01	-0.150000	2.98e-01
RHOF GTPase cycle	38	1.09e-01	-0.150000	2.03e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	1.11e-01	-0.149000	2.05e-01
Nucleosome assembly	38	1.11e-01	-0.149000	2.05e-01
RHO GTPases Activate Formins	128	3.70e-03	-0.149000	1.33e-02
Activation of caspases through apoptosome-mediated cleavage	6	5.29e-01	-0.148000	6.54e-01
IKK complex recruitment mediated by RIP1	23	2.19e-01	-0.148000	3.43e-01
Integration of energy metabolism	88	1.66e-02	-0.148000	4.41e-02
PI5P Regulates TP53 Acetylation	8	4.70e-01	-0.148000	5.99e-01
Mitochondrial unfolded protein response (UPRmt)	17	2.93e-01	-0.147000	4.25e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	5.00e-01	-0.147000	6.25e-01
TGFBR3 expression	20	2.56e-01	0.147000	3.85e-01
Signaling by LTK in cancer	7	5.02e-01	-0.146000	6.27e-01
Signaling by NOTCH2	33	1.45e-01	-0.146000	2.49e-01
Tie2 Signaling	16	3.11e-01	-0.146000	4.45e-01
MyD88-independent TLR4 cascade	108	8.68e-03	-0.146000	2.63e-02
TRIF (TICAM1)-mediated TLR4 signaling	108	8.68e-03	-0.146000	2.63e-02
Insulin receptor signalling cascade	40	1.11e-01	-0.146000	2.04e-01
Biosynthesis of EPA-derived SPMs	6	5.36e-01	-0.146000	6.62e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	3.46e-01	-0.146000	4.83e-01
Relaxin receptors	5	5.73e-01	-0.146000	6.93e-01
Loss of Function of TGFBR1 in Cancer	7	5.06e-01	-0.145000	6.30e-01
Response to metal ions	6	5.40e-01	-0.144000	6.66e-01
Activation of ATR in response to replication stress	37	1.30e-01	-0.144000	2.31e-01
Signaling by FGFR3	32	1.61e-01	-0.143000	2.71e-01
Homology Directed Repair	110	9.63e-03	-0.143000	2.87e-02
Effects of PIP2 hydrolysis	24	2.26e-01	-0.143000	3.51e-01
Extra-nuclear estrogen signaling	65	4.71e-02	-0.142000	1.03e-01
RHOA GTPase cycle	138	3.92e-03	-0.142000	1.40e-02
N-Glycan antennae elongation	13	3.75e-01	-0.142000	5.12e-01
RHOC GTPase cycle	71	3.84e-02	-0.142000	8.66e-02
Signaling by SCF-KIT	40	1.20e-01	-0.142000	2.18e-01
Physiological factors	9	4.61e-01	0.142000	5.90e-01
Maternal to zygotic transition (MZT)	72	3.74e-02	-0.142000	8.51e-02
Transcription of E2F targets under negative control by DREAM complex	19	2.85e-01	-0.142000	4.19e-01
PI-3K cascade:FGFR3	10	4.38e-01	0.142000	5.73e-01
VxPx cargo-targeting to cilium	19	2.85e-01	-0.142000	4.19e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	4.89e-01	-0.141000	6.16e-01
NR1H2 and NR1H3-mediated signaling	38	1.32e-01	-0.141000	2.32e-01
SUMOylation of transcription cofactors	44	1.06e-01	-0.141000	1.98e-01
tRNA processing in the nucleus	59	6.13e-02	-0.141000	1.28e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	3.80e-01	0.141000	5.15e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	18	3.02e-01	-0.141000	4.35e-01
The canonical retinoid cycle in rods (twilight vision)	9	4.65e-01	-0.141000	5.94e-01
Plasma lipoprotein remodeling	18	3.02e-01	-0.141000	4.35e-01
Negative regulation of the PI3K/AKT network	91	2.05e-02	-0.141000	5.28e-02
RHOU GTPase cycle	40	1.24e-01	-0.140000	2.23e-01
Extracellular matrix organization	219	3.41e-04	-0.140000	1.75e-03
Toll Like Receptor 3 (TLR3) Cascade	104	1.34e-02	-0.140000	3.74e-02
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	4.21e-01	-0.140000	5.56e-01
ECM proteoglycans	47	9.69e-02	-0.140000	1.84e-01
Amine ligand-binding receptors	10	4.47e-01	0.139000	5.79e-01
STAT5 activation downstream of FLT3 ITD mutants	9	4.71e-01	-0.139000	5.99e-01
Aquaporin-mediated transport	38	1.39e-01	-0.139000	2.42e-01
STING mediated induction of host immune responses	15	3.53e-01	-0.139000	4.88e-01
RSV-host interactions	78	3.46e-02	-0.138000	8.01e-02
NFE2L2 regulating ER-stress associated genes	5	5.94e-01	0.138000	7.11e-01
RUNX3 regulates p14-ARF	10	4.53e-01	0.137000	5.84e-01
RAC2 GTPase cycle	85	2.94e-02	-0.137000	7.04e-02
Interleukin-10 signaling	39	1.41e-01	0.136000	2.44e-01
TP53 Regulates Transcription of Cell Death Genes	43	1.22e-01	-0.136000	2.22e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	5.98e-01	-0.136000	7.11e-01
Activation of SMO	14	3.79e-01	-0.136000	5.15e-01
PLC beta mediated events	40	1.38e-01	-0.136000	2.41e-01
RHOJ GTPase cycle	49	1.01e-01	-0.135000	1.90e-01
Metalloprotease DUBs	20	2.96e-01	-0.135000	4.28e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	4.83e-01	0.135000	6.10e-01
Signaling by FGFR4 in disease	11	4.39e-01	0.135000	5.73e-01
Meiosis	67	5.67e-02	-0.135000	1.20e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	2.86e-01	-0.134000	4.20e-01
Passive transport by Aquaporins	6	5.69e-01	0.134000	6.90e-01
Establishment of Sister Chromatid Cohesion	11	4.41e-01	0.134000	5.74e-01
Chromatin modifying enzymes	214	7.22e-04	-0.134000	3.32e-03
Chromatin organization	214	7.22e-04	-0.134000	3.32e-03
Transport of RCbl within the body	8	5.12e-01	-0.134000	6.34e-01
SHC1 events in EGFR signaling	11	4.42e-01	-0.134000	5.74e-01
RHOV GTPase cycle	36	1.65e-01	-0.134000	2.76e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	623	1.53e-08	-0.133000	1.53e-07
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	3.90e-01	-0.133000	5.23e-01
Regulation of PTEN mRNA translation	13	4.08e-01	0.133000	5.41e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	1.35e-02	-0.132000	3.75e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	3.06e-01	-0.132000	4.39e-01
Signaling by EGFR	47	1.18e-01	-0.132000	2.15e-01
Defective binding of VWF variant to GPIb:IX:V	6	5.76e-01	0.132000	6.95e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	6	5.76e-01	0.132000	6.95e-01
Formation of the beta-catenin:TCF transactivating complex	44	1.31e-01	-0.132000	2.31e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	2.06e-02	-0.131000	5.31e-02
Signaling by ALK fusions and activated point mutants	89	3.24e-02	-0.131000	7.63e-02
Signaling by ALK in cancer	89	3.24e-02	-0.131000	7.63e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	35	1.80e-01	-0.131000	2.95e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	5.79e-01	-0.131000	6.97e-01
MITF-M-regulated melanocyte development	113	1.64e-02	-0.131000	4.38e-02
mRNA 3’-end processing	57	8.86e-02	-0.130000	1.70e-01
Formation of the ureteric bud	5	6.14e-01	0.130000	7.24e-01
RAC3 GTPase cycle	87	3.62e-02	-0.130000	8.30e-02
ABC transporters in lipid homeostasis	14	4.00e-01	0.130000	5.33e-01
Adipogenesis	95	2.88e-02	-0.130000	6.93e-02
PI3K events in ERBB2 signaling	11	4.58e-01	0.129000	5.87e-01
FOXO-mediated transcription	58	9.03e-02	-0.129000	1.73e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	6.19e-01	-0.129000	7.27e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	6.19e-01	-0.129000	7.27e-01
Cargo trafficking to the periciliary membrane	48	1.24e-01	-0.128000	2.22e-01
Signaling by TGF-beta Receptor Complex	90	3.57e-02	-0.128000	8.19e-02
Activation of the AP-1 family of transcription factors	10	4.84e-01	-0.128000	6.11e-01
Diseases of mitotic cell cycle	38	1.73e-01	-0.128000	2.86e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	6.21e-01	0.128000	7.28e-01
Signaling by KIT in disease	20	3.28e-01	-0.126000	4.63e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	3.28e-01	-0.126000	4.63e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	6.25e-01	-0.126000	7.30e-01
Acyl chain remodelling of PE	20	3.29e-01	-0.126000	4.64e-01
Apoptotic execution phase	46	1.41e-01	-0.125000	2.45e-01
Fibronectin matrix formation	6	5.96e-01	-0.125000	7.11e-01
Signal Transduction	2051	9.44e-21	-0.125000	3.79e-19
Signaling by Rho GTPases	607	1.46e-07	-0.125000	1.23e-06
Formation of the Editosome	6	5.97e-01	0.125000	7.11e-01
mRNA Editing: C to U Conversion	6	5.97e-01	0.125000	7.11e-01
Transcriptional activation of mitochondrial biogenesis	52	1.21e-01	-0.124000	2.20e-01
NFE2L2 regulating tumorigenic genes	11	4.76e-01	0.124000	6.04e-01
MET promotes cell motility	34	2.11e-01	-0.124000	3.31e-01
Organelle biogenesis and maintenance	278	3.74e-04	-0.124000	1.89e-03
SHC-mediated cascade:FGFR2	13	4.39e-01	0.124000	5.73e-01
SOS-mediated signalling	7	5.70e-01	-0.124000	6.91e-01
RAS signaling downstream of NF1 loss-of-function variants	7	5.71e-01	-0.124000	6.91e-01
p130Cas linkage to MAPK signaling for integrins	11	4.78e-01	-0.124000	6.05e-01
HCMV Early Events	84	5.07e-02	-0.123000	1.09e-01
Downstream signal transduction	27	2.68e-01	-0.123000	4.00e-01
Integrin cell surface interactions	65	8.61e-02	-0.123000	1.68e-01
PKR-mediated signaling	67	8.19e-02	-0.123000	1.61e-01
NOD1/2 Signaling Pathway	36	2.04e-01	-0.122000	3.23e-01
G-protein mediated events	44	1.60e-01	-0.122000	2.70e-01
Rap1 signalling	14	4.29e-01	-0.122000	5.64e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	5.37e-02	-0.122000	1.15e-01
Signaling by RNF43 mutants	7	5.78e-01	-0.121000	6.96e-01
Death Receptor Signaling	145	1.17e-02	-0.121000	3.35e-02
Signaling by TGFB family members	137	1.43e-02	-0.121000	3.94e-02
SHC1 events in ERBB2 signaling	17	3.89e-01	-0.121000	5.23e-01
Non-integrin membrane-ECM interactions	49	1.46e-01	-0.120000	2.50e-01
RHOD GTPase cycle	49	1.46e-01	-0.120000	2.50e-01
Protein lipoylation	10	5.11e-01	-0.120000	6.34e-01
RHOB GTPase cycle	64	9.86e-02	-0.119000	1.87e-01
Cytokine Signaling in Immune system	668	1.50e-07	-0.119000	1.25e-06
Processing of Intronless Pre-mRNAs	20	3.60e-01	-0.118000	4.96e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	4.97e-01	0.118000	6.23e-01
Negative regulation of MET activity	18	3.86e-01	-0.118000	5.20e-01
Interleukin-6 family signaling	20	3.62e-01	0.118000	5.00e-01
SHC-mediated cascade:FGFR1	13	4.63e-01	-0.118000	5.92e-01
HDL assembly	6	6.18e-01	-0.117000	7.27e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	5.95e-01	0.116000	7.11e-01
Nonhomologous End-Joining (NHEJ)	40	2.05e-01	-0.116000	3.25e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	3.76e-02	-0.116000	8.55e-02
Activation of AMPK downstream of NMDARs	20	3.71e-01	-0.116000	5.08e-01
Leading Strand Synthesis	14	4.54e-01	-0.116000	5.84e-01
Polymerase switching	14	4.54e-01	-0.116000	5.84e-01
SLC-mediated transmembrane transport	174	8.57e-03	-0.116000	2.62e-02
Phospholipid metabolism	183	7.11e-03	-0.115000	2.29e-02
Signaling by MAPK mutants	6	6.25e-01	-0.115000	7.31e-01
Regulation of TNFR1 signaling	47	1.72e-01	-0.115000	2.86e-01
Regulation of MITF-M-dependent genes involved in pigmentation	38	2.20e-01	-0.115000	3.43e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	1.68e-01	-0.115000	2.81e-01
SUMO is proteolytically processed	6	6.27e-01	-0.115000	7.32e-01
POLB-Dependent Long Patch Base Excision Repair	8	5.76e-01	-0.114000	6.95e-01
Maturation of nucleoprotein 9694631	15	4.45e-01	-0.114000	5.77e-01
Signaling by PDGF	48	1.73e-01	-0.114000	2.86e-01
DCC mediated attractive signaling	13	4.78e-01	-0.114000	6.05e-01
Dectin-2 family	19	3.91e-01	-0.114000	5.24e-01
Synthesis of 15-eicosatetraenoic acid derivatives	6	6.31e-01	-0.113000	7.36e-01
Vitamin B5 (pantothenate) metabolism	20	3.80e-01	-0.113000	5.16e-01
Ca-dependent events	30	2.83e-01	-0.113000	4.17e-01
SUMOylation of chromatin organization proteins	57	1.39e-01	-0.113000	2.42e-01
CaMK IV-mediated phosphorylation of CREB	9	5.57e-01	0.113000	6.80e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	4.35e-01	0.113000	5.70e-01
MET activates PTK2 signaling	23	3.50e-01	-0.113000	4.84e-01
Signaling by TGFBR3	39	2.23e-01	-0.113000	3.47e-01
Diseases of hemostasis	14	4.66e-01	-0.113000	5.94e-01
Sensory processing of sound by outer hair cells of the cochlea	41	2.14e-01	-0.112000	3.36e-01
Cellular response to heat stress	94	6.11e-02	-0.112000	1.28e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	1.19e-01	-0.111000	2.17e-01
FGFR2b ligand binding and activation	6	6.39e-01	0.110000	7.41e-01
RET signaling	32	2.81e-01	-0.110000	4.16e-01
Degradation of the extracellular matrix	96	6.25e-02	-0.110000	1.30e-01
Impaired BRCA2 binding to RAD51	35	2.62e-01	0.110000	3.93e-01
Signaling by FGFR2 in disease	33	2.76e-01	-0.109000	4.10e-01
RND3 GTPase cycle	35	2.65e-01	-0.109000	3.96e-01
MITF-M-dependent gene expression	84	8.47e-02	-0.109000	1.65e-01
Interleukin-35 Signalling	12	5.14e-01	-0.109000	6.37e-01
MET activates RAP1 and RAC1	10	5.52e-01	-0.109000	6.76e-01
Amino acid transport across the plasma membrane	25	3.47e-01	-0.109000	4.84e-01
PI3K/AKT Signaling in Cancer	84	8.61e-02	-0.108000	1.68e-01
Propionyl-CoA catabolism	5	6.76e-01	-0.108000	7.70e-01
Defects in vitamin and cofactor metabolism	21	3.93e-01	-0.108000	5.26e-01
Phase I - Functionalization of compounds	68	1.25e-01	-0.108000	2.23e-01
MET activates RAS signaling	10	5.56e-01	-0.108000	6.80e-01
Collagen degradation	42	2.30e-01	-0.107000	3.56e-01
Circadian Clock	67	1.30e-01	-0.107000	2.31e-01
LTC4-CYSLTR mediated IL4 production	5	6.80e-01	-0.107000	7.72e-01
Sphingolipid catabolism	11	5.44e-01	-0.106000	6.69e-01
Toxicity of botulinum toxin type D (botD)	5	6.82e-01	0.106000	7.74e-01
Toxicity of botulinum toxin type F (botF)	5	6.82e-01	0.106000	7.74e-01
Synthesis of PIPs at the Golgi membrane	16	4.66e-01	-0.105000	5.94e-01
PI3K Cascade	31	3.11e-01	-0.105000	4.45e-01
NFE2L2 regulating MDR associated enzymes	8	6.07e-01	0.105000	7.17e-01
Receptor Mediated Mitophagy	11	5.47e-01	-0.105000	6.72e-01
Small interfering RNA (siRNA) biogenesis	9	5.90e-01	-0.104000	7.07e-01
TNF signaling	56	1.79e-01	-0.104000	2.94e-01
Platelet Aggregation (Plug Formation)	29	3.36e-01	-0.103000	4.71e-01
Sensory Perception	194	1.33e-02	0.103000	3.71e-02
RUNX1 regulates transcription of genes involved in WNT signaling	5	6.90e-01	0.103000	7.80e-01
Phospholipase C-mediated cascade; FGFR3	5	6.92e-01	0.102000	7.82e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	3.09e-01	-0.102000	4.42e-01
Signaling by Leptin	10	5.76e-01	-0.102000	6.95e-01
RHO GTPases activate PAKs	20	4.30e-01	-0.102000	5.64e-01
Post NMDA receptor activation events	64	1.60e-01	-0.102000	2.70e-01
SUMO E3 ligases SUMOylate target proteins	161	2.62e-02	-0.102000	6.39e-02
Adrenaline,noradrenaline inhibits insulin secretion	24	3.90e-01	-0.101000	5.23e-01
Transcriptional regulation of white adipocyte differentiation	77	1.24e-01	-0.101000	2.22e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	6.43e-01	0.101000	7.44e-01
Hydrolysis of LPC	8	6.20e-01	-0.101000	7.28e-01
SUMOylation of RNA binding proteins	47	2.31e-01	-0.101000	3.56e-01
Peptide hormone metabolism	53	2.03e-01	-0.101000	3.23e-01
Adenylate cyclase inhibitory pathway	11	5.63e-01	-0.101000	6.85e-01
The phototransduction cascade	27	3.67e-01	0.100000	5.05e-01
HDMs demethylate histones	22	4.16e-01	0.100000	5.51e-01
TLR3-mediated TICAM1-dependent programmed cell death	6	6.72e-01	0.099900	7.67e-01
cGMP effects	12	5.49e-01	0.099900	6.74e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	5.85e-01	-0.099800	7.03e-01
GP1b-IX-V activation signalling	11	5.70e-01	-0.098900	6.91e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	6.28e-01	-0.098900	7.33e-01
SUMOylation	167	2.84e-02	-0.098300	6.86e-02
TICAM1, RIP1-mediated IKK complex recruitment	19	4.59e-01	-0.098100	5.89e-01
TICAM1-dependent activation of IRF3/IRF7	13	5.41e-01	-0.098000	6.67e-01
CLEC7A/inflammasome pathway	6	6.78e-01	-0.098000	7.71e-01
RHO GTPase cycle	411	6.70e-04	-0.097800	3.13e-03
Arachidonate metabolism	47	2.49e-01	-0.097300	3.79e-01
Defective C1GALT1C1 causes TNPS	10	5.94e-01	0.097200	7.11e-01
Keratan sulfate biosynthesis	20	4.53e-01	-0.096900	5.84e-01
Surfactant metabolism	20	4.53e-01	-0.096800	5.84e-01
Interleukin-20 family signaling	17	4.90e-01	0.096700	6.17e-01
NRAGE signals death through JNK	52	2.30e-01	-0.096200	3.56e-01
SUMOylation of immune response proteins	12	5.65e-01	-0.095900	6.87e-01
Regulation of HSF1-mediated heat shock response	79	1.41e-01	-0.095800	2.44e-01
Interleukin-9 signaling	8	6.40e-01	0.095600	7.41e-01
RNA polymerase II transcribes snRNA genes	71	1.64e-01	-0.095500	2.75e-01
Regulation of FOXO transcriptional activity by acetylation	10	6.02e-01	-0.095200	7.13e-01
Processing of DNA double-strand break ends	69	1.72e-01	-0.095000	2.86e-01
DAG and IP3 signaling	34	3.39e-01	-0.094700	4.75e-01
Striated Muscle Contraction	27	3.95e-01	0.094600	5.27e-01
Resolution of Sister Chromatid Cohesion	116	7.93e-02	-0.094300	1.57e-01
Inhibition of Signaling by Overexpressed EGFR	5	7.15e-01	-0.094300	7.96e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	7.15e-01	-0.094300	7.96e-01
CDC42 GTPase cycle	140	5.52e-02	-0.093900	1.17e-01
EGFR interacts with phospholipase C-gamma	6	6.91e-01	-0.093800	7.81e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	6.69e-01	-0.093400	7.66e-01
FOXO-mediated transcription of cell cycle genes	14	5.45e-01	-0.093400	6.70e-01
Regulation of NPAS4 gene expression	11	5.92e-01	0.093400	7.10e-01
HDR through Homologous Recombination (HRR)	68	1.83e-01	-0.093400	2.98e-01
TRAF6 mediated NF-kB activation	23	4.42e-01	-0.092600	5.74e-01
Epigenetic regulation of gene expression	264	1.00e-02	-0.092100	2.98e-02
Mitotic Spindle Checkpoint	108	9.87e-02	-0.092000	1.87e-01
Fatty acyl-CoA biosynthesis	35	3.48e-01	-0.091700	4.84e-01
RUNX3 regulates WNT signaling	8	6.53e-01	0.091700	7.52e-01
Ion channel transport	141	6.07e-02	-0.091500	1.27e-01
EML4 and NUDC in mitotic spindle formation	107	1.02e-01	-0.091400	1.92e-01
Regulation of TP53 Activity through Phosphorylation	88	1.39e-01	-0.091300	2.42e-01
Nuclear Envelope Breakdown	53	2.51e-01	-0.091200	3.80e-01
Activation of NMDA receptors and postsynaptic events	74	1.75e-01	-0.091200	2.89e-01
PI-3K cascade:FGFR4	11	6.01e-01	0.091100	7.12e-01
Adenylate cyclase activating pathway	8	6.56e-01	-0.090900	7.54e-01
Signaling by Erythropoietin	24	4.42e-01	-0.090700	5.74e-01
Elastic fibre formation	33	3.68e-01	-0.090500	5.05e-01
TRAF6 mediated IRF7 activation	15	5.45e-01	0.090200	6.70e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	3.19e-01	0.090000	4.52e-01
Diseases of DNA Double-Strand Break Repair	41	3.19e-01	0.090000	4.52e-01
Vitamin B2 (riboflavin) metabolism	6	7.04e-01	-0.089600	7.90e-01
Nuclear signaling by ERBB4	24	4.50e-01	-0.089100	5.82e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	6.83e-01	-0.089100	7.75e-01
Uptake and actions of bacterial toxins	27	4.25e-01	-0.088700	5.59e-01
CaM pathway	28	4.17e-01	-0.088500	5.52e-01
Calmodulin induced events	28	4.17e-01	-0.088500	5.52e-01
Nitric oxide stimulates guanylate cyclase	15	5.53e-01	0.088500	6.77e-01
Intraflagellar transport	47	2.97e-01	-0.088000	4.29e-01
FGFR2 ligand binding and activation	9	6.48e-01	0.088000	7.46e-01
SUMOylation of DNA replication proteins	46	3.03e-01	-0.087800	4.36e-01
Regulation of lipid metabolism by PPARalpha	107	1.19e-01	-0.087200	2.17e-01
Scavenging by Class A Receptors	12	6.01e-01	-0.087200	7.12e-01
RHO GTPases activate KTN1	11	6.17e-01	-0.087100	7.27e-01
Signaling by FGFR1 in disease	32	3.95e-01	0.086800	5.27e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	79	1.84e-01	-0.086500	2.98e-01
RHOBTB2 GTPase cycle	23	4.73e-01	-0.086400	6.01e-01
PPARA activates gene expression	105	1.28e-01	-0.086100	2.27e-01
Xenobiotics	12	6.06e-01	0.085900	7.17e-01
Deactivation of the beta-catenin transactivating complex	36	3.73e-01	-0.085800	5.10e-01
Plasma lipoprotein assembly	10	6.39e-01	-0.085600	7.41e-01
Synthesis of PA	31	4.15e-01	-0.084600	5.50e-01
RHOBTB GTPase Cycle	35	3.87e-01	-0.084400	5.21e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	5.85e-01	-0.084300	7.03e-01
Sensory perception of taste	22	4.94e-01	0.084100	6.20e-01
SHC1 events in ERBB4 signaling	10	6.47e-01	-0.083500	7.46e-01
Reproduction	86	1.81e-01	-0.083400	2.96e-01
RIPK1-mediated regulated necrosis	31	4.23e-01	-0.083100	5.57e-01
Regulation of necroptotic cell death	31	4.23e-01	-0.083100	5.57e-01
Cell junction organization	78	2.05e-01	-0.083000	3.25e-01
Activation of C3 and C5	7	7.06e-01	-0.082400	7.91e-01
Inwardly rectifying K+ channels	23	4.97e-01	-0.081800	6.23e-01
Activation of GABAB receptors	30	4.41e-01	-0.081200	5.74e-01
GABA B receptor activation	30	4.41e-01	-0.081200	5.74e-01
Recruitment of NuMA to mitotic centrosomes	88	1.89e-01	-0.081000	3.05e-01
Apoptotic cleavage of cellular proteins	35	4.07e-01	-0.080900	5.41e-01
Downstream signaling of activated FGFR3	17	5.66e-01	0.080500	6.87e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	3.31e-01	-0.080200	4.66e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	6.95e-01	0.080000	7.85e-01
Endosomal/Vacuolar pathway	12	6.33e-01	-0.079700	7.38e-01
Assembly of collagen fibrils and other multimeric structures	42	3.76e-01	-0.079000	5.12e-01
HDR through Single Strand Annealing (SSA)	37	4.07e-01	0.078800	5.40e-01
Caspase activation via Death Receptors in the presence of ligand	16	5.85e-01	0.078800	7.03e-01
Signaling by activated point mutants of FGFR1	5	7.61e-01	-0.078600	8.34e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	6.37e-01	-0.078600	7.40e-01
Norepinephrine Neurotransmitter Release Cycle	12	6.37e-01	0.078600	7.40e-01
FasL/ CD95L signaling	5	7.61e-01	0.078600	8.34e-01
Metabolism of non-coding RNA	53	3.24e-01	-0.078300	4.59e-01
snRNP Assembly	53	3.24e-01	-0.078300	4.59e-01
G alpha (q) signalling events	139	1.11e-01	-0.078200	2.05e-01
FGFR1c ligand binding and activation	8	7.02e-01	-0.078100	7.89e-01
Presynaptic depolarization and calcium channel opening	8	7.02e-01	0.078100	7.89e-01
NCAM1 interactions	26	4.92e-01	-0.077900	6.19e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	7.22e-01	-0.077700	8.03e-01
Homologous DNA Pairing and Strand Exchange	43	3.78e-01	0.077700	5.14e-01
Phospholipase C-mediated cascade: FGFR1	8	7.06e-01	-0.077100	7.91e-01
MECP2 regulates transcription factors	5	7.66e-01	0.076800	8.36e-01
Transport of Mature Transcript to Cytoplasm	81	2.32e-01	-0.076700	3.58e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	5.63e-01	0.076700	6.85e-01
Synthesis of PIPs at the ER membrane	5	7.67e-01	0.076600	8.37e-01
Synthesis of bile acids and bile salts	26	4.99e-01	-0.076500	6.25e-01
Stimuli-sensing channels	80	2.37e-01	-0.076500	3.64e-01
G alpha (12/13) signalling events	68	2.77e-01	-0.076200	4.10e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	2.09e-01	-0.076200	3.29e-01
Amplification of signal from the kinetochores	91	2.09e-01	-0.076200	3.29e-01
HDL remodeling	6	7.47e-01	0.076200	8.22e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	4.06e-01	0.075900	5.40e-01
HSF1-dependent transactivation	30	4.72e-01	-0.075900	6.00e-01
FGFR1 ligand binding and activation	10	6.78e-01	-0.075700	7.71e-01
L1CAM interactions	101	1.89e-01	-0.075700	3.05e-01
CD209 (DC-SIGN) signaling	20	5.59e-01	-0.075600	6.81e-01
G2/M DNA damage checkpoint	66	2.89e-01	-0.075500	4.22e-01
Nephrin family interactions	20	5.60e-01	0.075300	6.82e-01
Lewis blood group biosynthesis	13	6.40e-01	-0.075000	7.41e-01
Synthesis of UDP-N-acetyl-glucosamine	8	7.14e-01	-0.074900	7.96e-01
Regulation of endogenous retroelements	93	2.14e-01	-0.074500	3.36e-01
Molecules associated with elastic fibres	26	5.13e-01	-0.074200	6.35e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	4.12e-01	-0.074000	5.47e-01
SHC-mediated cascade:FGFR4	11	6.71e-01	-0.073900	7.67e-01
RND1 GTPase cycle	36	4.45e-01	-0.073500	5.77e-01
IRS-mediated signalling	35	4.52e-01	-0.073500	5.84e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	5.70e-01	-0.073300	6.91e-01
Diseases of DNA repair	51	3.68e-01	0.072800	5.05e-01
Antiviral mechanism by IFN-stimulated genes	140	1.38e-01	-0.072600	2.42e-01
Signaling by FGFR in disease	52	3.68e-01	-0.072200	5.05e-01
IGF1R signaling cascade	37	4.49e-01	-0.072000	5.81e-01
Repression of WNT target genes	14	6.44e-01	-0.071400	7.45e-01
Defective factor IX causes hemophilia B	6	7.62e-01	0.071300	8.34e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.83e-01	-0.071200	7.74e-01
Glutamate Neurotransmitter Release Cycle	19	5.92e-01	0.070900	7.10e-01
GAB1 signalosome	14	6.48e-01	-0.070600	7.46e-01
Signaling by NTRK3 (TRKC)	15	6.36e-01	-0.070500	7.40e-01
Activation of G protein gated Potassium channels	19	5.98e-01	-0.069800	7.11e-01
G protein gated Potassium channels	19	5.98e-01	-0.069800	7.11e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	19	5.98e-01	-0.069800	7.11e-01
Interleukin-23 signaling	7	7.49e-01	-0.069800	8.24e-01
Interleukin-37 signaling	19	6.00e-01	-0.069500	7.12e-01
Insulin processing	19	6.02e-01	0.069100	7.13e-01
Signaling by cytosolic FGFR1 fusion mutants	18	6.13e-01	0.068900	7.23e-01
Transcriptional Regulation by VENTX	39	4.58e-01	-0.068700	5.87e-01
Mitotic Prometaphase	193	1.06e-01	-0.067400	1.98e-01
Wax and plasmalogen biosynthesis	5	7.96e-01	-0.066900	8.55e-01
Visual phototransduction	61	3.67e-01	-0.066800	5.04e-01
Fertilization	13	6.78e-01	0.066500	7.71e-01
Inactivation, recovery and regulation of the phototransduction cascade	26	5.59e-01	0.066100	6.82e-01
Factors involved in megakaryocyte development and platelet production	129	1.96e-01	-0.066000	3.14e-01
LGI-ADAM interactions	9	7.33e-01	-0.065600	8.13e-01
Beta-oxidation of very long chain fatty acids	11	7.09e-01	-0.065100	7.92e-01
RHO GTPases activate CIT	18	6.34e-01	-0.064900	7.38e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	6.75e-01	-0.064700	7.69e-01
Activation of Ca-permeable Kainate Receptor	9	7.38e-01	0.064500	8.16e-01
Ionotropic activity of kainate receptors	9	7.38e-01	0.064500	8.16e-01
GPCR downstream signalling	399	2.71e-02	-0.064500	6.58e-02
Acyl chain remodelling of PG	11	7.13e-01	-0.064100	7.96e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	6.21e-01	0.063900	7.28e-01
Cell-Cell communication	110	2.48e-01	-0.063800	3.78e-01
Tryptophan catabolism	12	7.04e-01	-0.063400	7.90e-01
RAC1 GTPase cycle	172	1.52e-01	-0.063400	2.58e-01
Sodium/Proton exchangers	7	7.72e-01	-0.063200	8.39e-01
EGFR Transactivation by Gastrin	7	7.73e-01	0.063000	8.39e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	5.02e-01	-0.063000	6.27e-01
IkBA variant leads to EDA-ID	7	7.73e-01	0.062900	8.39e-01
Ca2+ activated K+ channels	6	7.90e-01	-0.062700	8.51e-01
CYP2E1 reactions	5	8.12e-01	0.061500	8.70e-01
G alpha (i) signalling events	196	1.41e-01	-0.061100	2.44e-01
Interactions of Vpr with host cellular proteins	37	5.22e-01	-0.060800	6.46e-01
DAP12 signaling	28	5.79e-01	-0.060500	6.97e-01
Deadenylation of mRNA	22	6.24e-01	-0.060400	7.30e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	5.57e-01	-0.060000	6.80e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	6.99e-01	-0.059700	7.87e-01
Ion homeostasis	42	5.04e-01	-0.059600	6.29e-01
Gain-of-function MRAS complexes activate RAF signaling	8	7.71e-01	0.059300	8.39e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	7.71e-01	0.059300	8.39e-01
Signaling by MRAS-complex mutants	8	7.71e-01	0.059300	8.39e-01
FRS-mediated FGFR3 signaling	12	7.22e-01	0.059300	8.03e-01
Defective GALNT12 causes CRCS1	9	7.59e-01	0.059000	8.33e-01
Attenuation phase	23	6.25e-01	-0.058900	7.30e-01
Cobalamin (Cbl) metabolism	7	7.88e-01	0.058600	8.49e-01
Regulation of RUNX1 Expression and Activity	18	6.67e-01	0.058500	7.65e-01
Defective B3GALTL causes PpS	27	5.99e-01	0.058500	7.11e-01
Serine biosynthesis	8	7.75e-01	0.058400	8.39e-01
GABA synthesis, release, reuptake and degradation	11	7.38e-01	-0.058300	8.16e-01
Mitochondrial Uncoupling	6	8.05e-01	0.058300	8.63e-01
tRNA modification in the nucleus and cytosol	43	5.08e-01	-0.058300	6.32e-01
Regulation of IFNA/IFNB signaling	12	7.27e-01	-0.058300	8.07e-01
Alpha-protein kinase 1 signaling pathway	11	7.40e-01	-0.057900	8.17e-01
GRB2 events in EGFR signaling	10	7.52e-01	-0.057600	8.26e-01
Apoptotic cleavage of cell adhesion proteins	8	7.78e-01	0.057500	8.41e-01
Aspirin ADME	15	7.01e-01	0.057400	7.88e-01
Class B/2 (Secretin family receptors)	57	4.55e-01	-0.057200	5.84e-01
Signaling by NTRK2 (TRKB)	20	6.58e-01	-0.057100	7.56e-01
Heme signaling	45	5.07e-01	0.057100	6.31e-01
Protein-protein interactions at synapses	58	4.55e-01	-0.056700	5.84e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	4.91e-01	-0.056300	6.18e-01
Neurotransmitter receptors and postsynaptic signal transmission	139	2.52e-01	-0.056200	3.81e-01
Gene expression (Transcription)	1404	4.17e-04	-0.056200	2.07e-03
Transcriptional Regulation by MECP2	49	5.01e-01	-0.055600	6.26e-01
E2F-enabled inhibition of pre-replication complex formation	9	7.75e-01	0.055000	8.39e-01
Signaling by GPCR	446	4.73e-02	-0.054800	1.03e-01
Centrosome maturation	81	3.94e-01	-0.054800	5.26e-01
Recruitment of mitotic centrosome proteins and complexes	81	3.94e-01	-0.054800	5.26e-01
Interleukin-7 signaling	21	6.64e-01	0.054700	7.61e-01
Sialic acid metabolism	28	6.17e-01	-0.054500	7.27e-01
Kidney development	17	6.97e-01	0.054500	7.86e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	7.00e-01	-0.054000	7.88e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	5.99e-01	0.053700	7.11e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	5.99e-01	0.053700	7.11e-01
Mitotic Telophase/Cytokinesis	13	7.38e-01	0.053600	8.16e-01
Downstream signaling of activated FGFR4	18	6.97e-01	0.053000	7.86e-01
PTK6 promotes HIF1A stabilization	6	8.22e-01	0.053000	8.77e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	4.38e-01	-0.052900	5.73e-01
Transcriptional Regulation by NPAS4	27	6.35e-01	-0.052700	7.39e-01
Prolactin receptor signaling	11	7.62e-01	-0.052700	8.34e-01
Signaling by ALK	24	6.57e-01	-0.052300	7.55e-01
Sensory processing of sound	58	4.92e-01	-0.052100	6.19e-01
Nuclear Receptor transcription pathway	38	5.78e-01	-0.052100	6.97e-01
TNFR1-induced proapoptotic signaling	24	6.60e-01	0.051900	7.57e-01
RNA Polymerase II Transcription	1197	2.66e-03	-0.051600	1.02e-02
SLC transporter disorders	76	4.38e-01	-0.051500	5.73e-01
Potassium Channels	64	4.77e-01	0.051400	6.05e-01
Defects of platelet adhesion to exposed collagen	7	8.14e-01	0.051400	8.70e-01
Synthesis of PI	5	8.44e-01	-0.050700	8.90e-01
ZBP1(DAI) mediated induction of type I IFNs	20	6.96e-01	0.050500	7.85e-01
Regulation of Expression and Function of Type II Classical Cadherins	24	6.70e-01	0.050300	7.66e-01
Regulation of Homotypic Cell-Cell Adhesion	24	6.70e-01	0.050300	7.66e-01
Intrinsic Pathway of Fibrin Clot Formation	15	7.37e-01	0.050100	8.16e-01
O-glycosylation of TSR domain-containing proteins	28	6.47e-01	0.050100	7.46e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	6.25e-01	0.050000	7.30e-01
Androgen biosynthesis	5	8.47e-01	0.050000	8.92e-01
Neurexins and neuroligins	38	5.98e-01	-0.049400	7.11e-01
IRS-related events triggered by IGF1R	36	6.11e-01	-0.049000	7.21e-01
Cilium Assembly	187	2.50e-01	-0.048800	3.79e-01
Interleukin-6 signaling	11	7.81e-01	-0.048400	8.43e-01
CREB phosphorylation	7	8.24e-01	0.048400	8.78e-01
Regulation of insulin secretion	63	5.06e-01	-0.048400	6.30e-01
Signaling by ERBB2 KD Mutants	20	7.09e-01	0.048200	7.92e-01
Glycerophospholipid catabolism	7	8.25e-01	0.048200	8.79e-01
Generic Transcription Pathway	1079	7.86e-03	-0.047900	2.48e-02
Biosynthesis of specialized proresolving mediators (SPMs)	16	7.42e-01	-0.047600	8.18e-01
Myogenesis	20	7.14e-01	-0.047300	7.96e-01
Assembly and cell surface presentation of NMDA receptors	34	6.34e-01	-0.047200	7.38e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	6.85e-01	0.046900	7.76e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	8.30e-01	0.046800	8.81e-01
Sensory processing of sound by inner hair cells of the cochlea	54	5.57e-01	-0.046200	6.80e-01
Defective RIPK1-mediated regulated necrosis	7	8.33e-01	-0.045900	8.83e-01
DAP12 interactions	39	6.21e-01	-0.045700	7.28e-01
Transmission across Chemical Synapses	183	2.89e-01	-0.045400	4.22e-01
TRAF3-dependent IRF activation pathway	13	7.77e-01	0.045400	8.40e-01
Export of Viral Ribonucleoproteins from Nucleus	33	6.53e-01	0.045200	7.52e-01
Regulation of CDH19 Expression and Function	6	8.51e-01	-0.044200	8.97e-01
HDR through MMEJ (alt-NHEJ)	12	7.91e-01	0.044100	8.51e-01
Acyl chain remodelling of PC	19	7.40e-01	-0.043900	8.17e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	8.20e-01	-0.043900	8.75e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	16	7.62e-01	0.043700	8.34e-01
Interferon Signaling	240	2.44e-01	-0.043700	3.73e-01
Long-term potentiation	18	7.49e-01	0.043600	8.24e-01
Crosslinking of collagen fibrils	13	7.88e-01	-0.043000	8.49e-01
Interleukin-15 signaling	14	7.81e-01	0.042900	8.43e-01
Transport of bile salts and organic acids, metal ions and amine compounds	53	5.97e-01	-0.042000	7.11e-01
Laminin interactions	26	7.15e-01	-0.041300	7.96e-01
Interferon alpha/beta signaling	64	5.68e-01	0.041300	6.90e-01
Growth hormone receptor signaling	20	7.50e-01	-0.041200	8.24e-01
NS1 Mediated Effects on Host Pathways	40	6.55e-01	0.040800	7.54e-01
MECP2 regulates neuronal receptors and channels	14	7.92e-01	-0.040700	8.52e-01
MECP2 regulates transcription of neuronal ligands	5	8.75e-01	-0.040600	9.16e-01
Signaling by ERBB2 TMD/JMD mutants	17	7.75e-01	-0.040100	8.39e-01
SHC-mediated cascade:FGFR3	10	8.27e-01	-0.039900	8.80e-01
Bile acid and bile salt metabolism	30	7.08e-01	-0.039600	7.92e-01
O-linked glycosylation of mucins	47	6.39e-01	-0.039500	7.41e-01
Signaling by LTK	10	8.29e-01	-0.039500	8.80e-01
Cardiac conduction	89	5.25e-01	0.039000	6.49e-01
Formation of WDR5-containing histone-modifying complexes	42	6.62e-01	-0.038900	7.60e-01
BBSome-mediated cargo-targeting to cilium	23	7.47e-01	-0.038900	8.22e-01
Nuclear Pore Complex (NPC) Disassembly	36	6.86e-01	-0.038900	7.77e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	7.88e-01	0.038800	8.49e-01
Defects in cobalamin (B12) metabolism	13	8.10e-01	-0.038600	8.68e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	6.04e-01	-0.038400	7.14e-01
Glycosphingolipid biosynthesis	15	7.97e-01	-0.038400	8.55e-01
FGFR4 ligand binding and activation	5	8.83e-01	0.038000	9.21e-01
Postmitotic nuclear pore complex (NPC) reformation	27	7.38e-01	-0.037200	8.16e-01
Dissolution of Fibrin Clot	12	8.24e-01	0.037000	8.78e-01
TNFR1-induced NF-kappa-B signaling pathway	32	7.19e-01	-0.036800	8.00e-01
Tight junction interactions	17	7.93e-01	0.036800	8.52e-01
Signaling by ERBB4	45	6.71e-01	-0.036600	7.67e-01
Transport of the SLBP independent Mature mRNA	35	7.08e-01	0.036500	7.92e-01
Regulation of NFE2L2 gene expression	8	8.58e-01	0.036500	9.01e-01
Peptide ligand-binding receptors	102	5.32e-01	0.035800	6.58e-01
FGFR1 mutant receptor activation	25	7.57e-01	0.035700	8.32e-01
Lysosphingolipid and LPA receptors	11	8.38e-01	-0.035600	8.87e-01
STAT3 nuclear events downstream of ALK signaling	11	8.39e-01	-0.035400	8.87e-01
Adherens junctions interactions	38	7.07e-01	-0.035200	7.92e-01
Downstream signaling of activated FGFR1	22	7.76e-01	0.035000	8.40e-01
Regulation of PLK1 Activity at G2/M Transition	87	5.75e-01	-0.034800	6.95e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	7.64e-01	0.034600	8.36e-01
ARMS-mediated activation	6	8.84e-01	0.034300	9.21e-01
AURKA Activation by TPX2	72	6.17e-01	-0.034100	7.27e-01
Regulation of gene expression in beta cells	8	8.70e-01	0.033300	9.12e-01
RIP-mediated NFkB activation via ZBP1	17	8.14e-01	0.033000	8.70e-01
Signaling by PDGFRA extracellular domain mutants	12	8.44e-01	0.032800	8.90e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.44e-01	0.032800	8.90e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	7.74e-01	0.032600	8.39e-01
P2Y receptors	10	8.58e-01	-0.032600	9.01e-01
Nicotinate metabolism	27	7.73e-01	-0.032000	8.39e-01
Kinesins	51	6.93e-01	-0.032000	7.83e-01
CHL1 interactions	8	8.76e-01	0.032000	9.16e-01
Lysine catabolism	11	8.56e-01	-0.031700	8.99e-01
TRAIL signaling	8	8.78e-01	0.031400	9.17e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	7.23e-01	-0.031300	8.03e-01
Interleukin-2 family signaling	38	7.39e-01	-0.031300	8.16e-01
Aspartate and asparagine metabolism	9	8.71e-01	0.031200	9.12e-01
Regulation of IFNG signaling	14	8.40e-01	0.031100	8.88e-01
Interactions of Rev with host cellular proteins	37	7.44e-01	-0.031000	8.20e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	7.66e-01	0.030400	8.36e-01
Biosynthesis of DHA-derived SPMs	14	8.44e-01	0.030300	8.90e-01
SUMOylation of DNA damage response and repair proteins	77	6.45e-01	-0.030300	7.46e-01
Collagen chain trimerization	27	7.88e-01	0.029900	8.49e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	6.99e-01	-0.029600	7.87e-01
Miscellaneous transport and binding events	20	8.19e-01	-0.029600	8.75e-01
Loss of Nlp from mitotic centrosomes	69	6.73e-01	-0.029400	7.67e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	6.73e-01	-0.029400	7.67e-01
WNT ligand biogenesis and trafficking	20	8.23e-01	-0.028900	8.78e-01
O-linked glycosylation	85	6.48e-01	-0.028700	7.46e-01
Nuclear import of Rev protein	34	7.73e-01	-0.028600	8.39e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	7.74e-01	0.028500	8.39e-01
Gamma-carboxylation of protein precursors	6	9.04e-01	-0.028500	9.36e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	8.67e-01	-0.027900	9.09e-01
FRS-mediated FGFR1 signaling	15	8.52e-01	-0.027900	8.97e-01
RHOBTB1 GTPase cycle	23	8.17e-01	-0.027800	8.74e-01
SHC-related events triggered by IGF1R	7	8.99e-01	-0.027700	9.32e-01
Rev-mediated nuclear export of HIV RNA	35	7.77e-01	-0.027600	8.41e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	8.53e-01	0.027600	8.97e-01
NrCAM interactions	6	9.07e-01	-0.027400	9.39e-01
Glucuronidation	8	8.95e-01	0.027100	9.28e-01
Regulation of beta-cell development	22	8.34e-01	-0.025900	8.83e-01
Neuronal System	270	4.65e-01	-0.025800	5.94e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	9.13e-01	-0.025700	9.41e-01
TGFBR1 KD Mutants in Cancer	6	9.13e-01	-0.025700	9.41e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	8.12e-01	-0.025000	8.70e-01
NOTCH2 intracellular domain regulates transcription	11	8.87e-01	0.024800	9.22e-01
Platelet Adhesion to exposed collagen	15	8.69e-01	0.024600	9.11e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	8.84e-01	0.024400	9.21e-01
Resolution of D-Loop Structures	35	8.07e-01	0.023800	8.66e-01
FRS-mediated FGFR4 signaling	13	8.86e-01	0.022900	9.22e-01
Synthesis of very long-chain fatty acyl-CoAs	22	8.53e-01	-0.022800	8.97e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	9.30e-01	-0.022600	9.54e-01
PI-3K cascade:FGFR1	13	8.90e-01	0.022100	9.25e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	18	8.76e-01	0.021200	9.16e-01
Blood group systems biosynthesis	17	8.80e-01	-0.021200	9.18e-01
Vitamin C (ascorbate) metabolism	8	9.18e-01	-0.021100	9.44e-01
Signaling by Hippo	18	8.77e-01	0.021100	9.17e-01
Netrin-1 signaling	35	8.30e-01	-0.021000	8.80e-01
Transport of the SLBP Dependant Mature mRNA	36	8.28e-01	0.021000	8.80e-01
RUNX3 regulates CDKN1A transcription	7	9.25e-01	0.020700	9.49e-01
Acyl chain remodelling of PI	10	9.12e-01	-0.020200	9.40e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	8.27e-01	-0.019500	8.80e-01
Phase 3 - rapid repolarisation	6	9.36e-01	-0.018800	9.59e-01
Interleukin-4 and Interleukin-13 signaling	92	7.64e-01	-0.018100	8.35e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	9.40e-01	0.017700	9.62e-01
Signaling by BMP	23	8.86e-01	-0.017300	9.22e-01
EPHA-mediated growth cone collapse	21	8.93e-01	-0.016900	9.27e-01
Phospholipase C-mediated cascade; FGFR4	6	9.45e-01	0.016400	9.64e-01
Synthesis of PIPs at the plasma membrane	52	8.38e-01	-0.016300	8.87e-01
Signaling by FLT3 ITD and TKD mutants	15	9.15e-01	0.015900	9.41e-01
TRP channels	22	9.01e-01	0.015400	9.34e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	9.53e-01	0.015200	9.69e-01
ISG15 antiviral mechanism	72	8.29e-01	-0.014700	8.80e-01
Signaling by ERBB2 in Cancer	21	9.08e-01	0.014600	9.39e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	9.10e-01	0.014600	9.39e-01
Trafficking of AMPA receptors	20	9.10e-01	0.014600	9.39e-01
Interleukin receptor SHC signaling	23	9.06e-01	0.014300	9.38e-01
Cell-cell junction organization	57	8.54e-01	-0.014100	8.97e-01
Signaling by ERBB2 ECD mutants	15	9.25e-01	0.014100	9.49e-01
Regulation of CDH11 Expression and Function	22	9.11e-01	0.013800	9.39e-01
ERBB2 Activates PTK6 Signaling	8	9.46e-01	0.013800	9.65e-01
Acetylcholine Neurotransmitter Release Cycle	10	9.40e-01	-0.013700	9.62e-01
Regulation of CDH11 function	9	9.44e-01	-0.013500	9.64e-01
Activated NTRK2 signals through FRS2 and FRS3	8	9.47e-01	0.013500	9.65e-01
SUMOylation of ubiquitinylation proteins	39	8.92e-01	-0.012600	9.26e-01
FLT3 signaling in disease	27	9.11e-01	-0.012500	9.39e-01
Cellular hexose transport	15	9.34e-01	-0.012300	9.57e-01
Diseases associated with O-glycosylation of proteins	50	8.81e-01	-0.012300	9.19e-01
Formation of Fibrin Clot (Clotting Cascade)	26	9.14e-01	-0.012200	9.41e-01
ROBO receptors bind AKAP5	7	9.58e-01	-0.011400	9.72e-01
GRB2 events in ERBB2 signaling	11	9.49e-01	-0.011200	9.66e-01
TRIF-mediated programmed cell death	9	9.55e-01	-0.010800	9.71e-01
Triglyceride biosynthesis	9	9.56e-01	0.010600	9.71e-01
Loss of Function of SMAD2/3 in Cancer	7	9.63e-01	0.009990	9.75e-01
Phase 2 - plateau phase	11	9.58e-01	0.009210	9.72e-01
Dopamine Neurotransmitter Release Cycle	18	9.51e-01	-0.008330	9.68e-01
Formation of the nephric duct	8	9.68e-01	-0.008140	9.78e-01
Nicotinamide salvaging	16	9.57e-01	0.007820	9.71e-01
Ca2+ pathway	58	9.24e-01	-0.007270	9.49e-01
Regulation of MECP2 expression and activity	29	9.46e-01	-0.007200	9.65e-01
Acyl chain remodelling of PS	14	9.63e-01	-0.007200	9.75e-01
Interferon gamma signaling	90	9.08e-01	0.007060	9.39e-01
GABA receptor activation	36	9.42e-01	0.006980	9.63e-01
RHO GTPases Activate ROCKs	18	9.59e-01	-0.006920	9.72e-01
PKMTs methylate histone lysines	43	9.41e-01	0.006530	9.62e-01
Neurotransmitter release cycle	35	9.47e-01	-0.006440	9.65e-01
Netrin mediated repulsion signals	5	9.82e-01	-0.005680	9.89e-01
FGFRL1 modulation of FGFR1 signaling	7	9.81e-01	-0.005180	9.88e-01
Nephron development	5	9.87e-01	-0.004360	9.91e-01
Cytochrome P450 - arranged by substrate type	39	9.63e-01	0.004260	9.75e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	9.76e-01	0.004160	9.84e-01
Class A/1 (Rhodopsin-like receptors)	177	9.27e-01	0.004000	9.51e-01
Serotonin Neurotransmitter Release Cycle	13	9.82e-01	-0.003660	9.88e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	9.89e-01	0.003590	9.92e-01
Maple Syrup Urine Disease	5	9.89e-01	0.003590	9.92e-01
Constitutive Signaling by EGFRvIII	14	9.83e-01	0.003220	9.89e-01
Signaling by EGFRvIII in Cancer	14	9.83e-01	0.003220	9.89e-01
Ion transport by P-type ATPases	44	9.71e-01	0.003160	9.80e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	9.79e-01	-0.003070	9.86e-01
Anchoring of the basal body to the plasma membrane	97	9.59e-01	0.003030	9.72e-01
GPCR ligand binding	245	9.39e-01	-0.002840	9.61e-01
Vpr-mediated nuclear import of PICs	34	9.78e-01	0.002750	9.86e-01
PI Metabolism	79	9.71e-01	0.002380	9.80e-01
Muscle contraction	145	9.67e-01	-0.001990	9.78e-01
Activation of Matrix Metalloproteinases	22	9.88e-01	-0.001930	9.92e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	9.90e-01	0.001730	9.92e-01
Termination of O-glycan biosynthesis	16	9.92e-01	0.001500	9.93e-01
NCAM signaling for neurite out-growth	47	9.90e-01	-0.001020	9.92e-01
Neurotransmitter clearance	5	9.97e-01	-0.000851	9.98e-01
RORA activates gene expression	18	9.96e-01	-0.000717	9.97e-01
SUMOylation of SUMOylation proteins	35	9.98e-01	0.000250	9.98e-01

---

Detailed Gene set reports

Modulation by Mtb of host immune system

set	Modulation by Mtb of host immune system
setSize	7
pANOVA	0.000174
s.dist	-0.819
p.adjustANOVA	0.000946

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRC1	-10460
UBA52	-10330
TLR2	-9371
RPS27A	-8752
UBC	-8746
B2M	-7645
UBB	-6271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRC1	-10460
UBA52	-10330
TLR2	-9371
RPS27A	-8752
UBC	-8746
B2M	-7645
UBB	-6271

---

Peptide chain elongation

set	Peptide chain elongation
setSize	87
pANOVA	1.12e-39
s.dist	-0.816
p.adjustANOVA	1.08e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
EEF2	-10569
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
EEF1A1	-10142

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
EEF2	-10569
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
EEF1A1	-10142
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
RPL26L1	-6583
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
RPS27L	700
RPL9	3866
RPS26	9968

---

Maturation of spike protein_9683686

set	Maturation of spike protein_9683686
setSize	5
pANOVA	0.00177
s.dist	-0.807
p.adjustANOVA	0.00715

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKCSH	-9568
GANAB	-9190
CANX	-8724
MGAT1	-8703
MOGS	-7158

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKCSH	-9568
GANAB	-9190
CANX	-8724
MGAT1	-8703
MOGS	-7158

---

Viral mRNA Translation

set	Viral mRNA Translation
setSize	87
pANOVA	9.09e-39
s.dist	-0.806
p.adjustANOVA	7.96e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
GRSF1	-6818
RPL26L1	-6583
RPL36A	-5184
RPSA	-5038
DNAJC3	-4625
RPL39L	-3913
RPS27L	700
RPL9	3866
RPS26	9968

---

Formation of ATP by chemiosmotic coupling

set	Formation of ATP by chemiosmotic coupling
setSize	20
pANOVA	6.05e-10
s.dist	-0.799
p.adjustANOVA	7.82e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5F1B	-10699
ATP5F1A	-10568
ATP5MC2	-10562
ATP5MC3	-10487
ATP5PF	-10425
ATP5MG	-10128
ATP5F1E	-10119
ATP5PO	-10110
ATP5MK	-9922
ATP5MF	-9834
ATP5MJ	-9606
ATP5ME	-9399
ATP5PB	-8221
ATP5MC1	-8108
ATP5F1D	-7704
ATP5PD	-7060
ATP5F1C	-6922
MT-ATP8	-4401
MT-ATP6	-3869
DMAC2L	-3285

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5F1B	-10699
ATP5F1A	-10568
ATP5MC2	-10562
ATP5MC3	-10487
ATP5PF	-10425
ATP5MG	-10128
ATP5F1E	-10119
ATP5PO	-10110
ATP5MK	-9922
ATP5MF	-9834
ATP5MJ	-9606
ATP5ME	-9399
ATP5PB	-8221
ATP5MC1	-8108
ATP5F1D	-7704
ATP5PD	-7060
ATP5F1C	-6922
MT-ATP8	-4401
MT-ATP6	-3869
DMAC2L	-3285

---

Eukaryotic Translation Elongation

set	Eukaryotic Translation Elongation
setSize	92
pANOVA	5.11e-40
s.dist	-0.797
p.adjustANOVA	5.18e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
EEF2	-10569
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
EEF1A1P5	-10173
RPS4X	-10160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
EEF2	-10569
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
EEF1A1P5	-10173
RPS4X	-10160
EEF1A1	-10142
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
EEF1B2	-9367
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
EEF1D	-8314
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
EEF1G	-7677
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
RPL26L1	-6583
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
RPS27L	700
RPL9	3866
RPS26	9968
EEF1A2	10941

---

Formation of a pool of free 40S subunits

set	Formation of a pool of free 40S subunits
setSize	99
pANOVA	7.16e-42
s.dist	-0.787
p.adjustANOVA	9.19e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EIF3L	-9711
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF3D	-9260
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
RPL14	-8455
EIF3B	-8401
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
EIF3H	-7624
RPL6	-7576
EIF3M	-7485
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
EIF3E	-6763
RPL26L1	-6583
EIF3C	-5489
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
EIF3A	-1310
EIF3J	295
EIF1AX	542
RPS27L	700
RPL9	3866
RPS26	9968

---

SARS-CoV-1 modulates host translation machinery

set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	3.16e-16
s.dist	-0.786
p.adjustANOVA	8.47e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
EEF1A1	-10142
RPS11	-10103
RPS15	-10066
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPS10	-9908
RPS25	-9803
RPS15A	-9791
RPS3	-9752
RPS18	-9323

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
EEF1A1	-10142
RPS11	-10103
RPS15	-10066
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPS10	-9908
RPS25	-9803
RPS15A	-9791
RPS3	-9752
RPS18	-9323
RPS2	-9201
RPS20	-9131
RPS6	-9020
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPS24	-8225
RPS4Y1	-8157
RPS14	-7754
HNRNPA1	-7741
RPS3A	-7224
RPS5	-7122
RPSA	-5038
RPS27L	700
RPS26	9968

---

Eukaryotic Translation Termination

set	Eukaryotic Translation Termination
setSize	91
pANOVA	3.33e-38
s.dist	-0.782
p.adjustANOVA	2.67e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
TRMT112	-10258
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
TRMT112	-10258
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
APEH	-9974
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
RPL26L1	-6583
ETF1	-5979
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
N6AMT1	-817
RPS27L	700
GSPT2	886
RPL9	3866
GSPT1	3983
RPS26	9968

---

Glycosphingolipid transport

set	Glycosphingolipid transport
setSize	7
pANOVA	0.000407
s.dist	-0.772
p.adjustANOVA	0.00204

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARF1	-10396
CPTP	-10222
GLTP	-10055
CLN3	-8906
ESYT1	-7594
ESYT2	-6294
PLEKHA8	-4464

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARF1	-10396
CPTP	-10222
GLTP	-10055
CLN3	-8906
ESYT1	-7594
ESYT2	-6294
PLEKHA8	-4464

---

Selenocysteine synthesis

set	Selenocysteine synthesis
setSize	91
pANOVA	8.71e-37
s.dist	-0.767
p.adjustANOVA	6.21e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EEFSEC	-9698
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
SARS1	-7474
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
RPL26L1	-6583
SEPHS2	-6487
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
RPS27L	700
RPL9	3866
SEPSECS	4292
SECISBP2	4936
PSTK	7426
RPS26	9968

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	93
pANOVA	2.12e-37
s.dist	-0.765
p.adjustANOVA	1.57e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
PABPC1	-9845
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
UPF1	-6632
RPL26L1	-6583
ETF1	-5979
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
NCBP2	-835
RPS27L	700
GSPT2	886
RPL9	3866
GSPT1	3983
NCBP1	6091
RPS26	9968

---

Sulfide oxidation to sulfate

set	Sulfide oxidation to sulfate
setSize	5
pANOVA	0.00328
s.dist	-0.759
p.adjustANOVA	0.0121

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC25A10	-10243
TST	-10120
ETHE1	-9997
SUOX	-6686
TSTD1	-3656

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC25A10	-10243
TST	-10120
ETHE1	-9997
SUOX	-6686
TSTD1	-3656

---

SRP-dependent cotranslational protein targeting to membrane

set	SRP-dependent cotranslational protein targeting to membrane
setSize	110
pANOVA	6.09e-43
s.dist	-0.757
p.adjustANOVA	9.78e-41

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DDOST	-10744
RPL37A	-10646
RPN2	-10639
RPN1	-10590
SSR4	-10533
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
SEC61B	-10435
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
SEC61A1	-10321
RPL23	-10304
RPL15	-10281
SEC61G	-10248
RPS16	-10239

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DDOST	-10744
RPL37A	-10646
RPN2	-10639
RPN1	-10590
SSR4	-10533
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
SEC61B	-10435
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
SEC61A1	-10321
RPL23	-10304
RPL15	-10281
SEC61G	-10248
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
SRPRB	-9681
RPL7	-9675
SSR2	-9662
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
SRP14	-9193
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
SEC11A	-9087
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
SPCS1	-8603
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
SRPRA	-7887
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
SEC11C	-6880
RPL26L1	-6583
SRP72	-6328
TRAM1	-5623
RPL36A	-5184
RPSA	-5038
SPCS3	-4212
SSR3	-4030
SSR1	-4005
RPL39L	-3913
SPCS2	-3884
SRP9	-3788
SRP68	-1449
RPS27L	700
SRP19	3641
RPL9	3866
SRP54	6973
SEC61A2	7907
RPS26	9968

---

L13a-mediated translational silencing of Ceruloplasmin expression

set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	109
pANOVA	5.47e-42
s.dist	-0.751
p.adjustANOVA	7.53e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
PABPC1	-9845
RPL36	-9833
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
RPL14	-8455
EIF3B	-8401
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
EIF3H	-7624
RPL6	-7576
EIF3M	-7485
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
EIF3E	-6763
RPL26L1	-6583
EIF3C	-5489
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF2S2	-4154
RPL39L	-3913
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF4E	2573
RPL9	3866
EIF4A2	4083
RPS26	9968

---

Formation of annular gap junctions

set	Formation of annular gap junctions
setSize	10
pANOVA	4.28e-05
s.dist	-0.747
p.adjustANOVA	0.000257

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTA	-10570
AP2M1	-10046
ACTG1	-9851
DNM2	-9813
CLTB	-9236
CLTCL1	-8384
DAB2	-7870
ACTB	-7106
CLTC	-4504
DNM1	-2695

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTA	-10570
AP2M1	-10046
ACTG1	-9851
DNM2	-9813
CLTB	-9236
CLTCL1	-8384
DAB2	-7870
ACTB	-7106
CLTC	-4504
DNM1	-2695

---

GTP hydrolysis and joining of the 60S ribosomal subunit

set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	110
pANOVA	8.06e-41
s.dist	-0.737
p.adjustANOVA	8.63e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
RPL14	-8455
EIF3B	-8401
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
EIF3H	-7624
RPL6	-7576
EIF3M	-7485
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
EIF3E	-6763
RPL26L1	-6583
EIF3C	-5489
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF5	-4985
EIF2S2	-4154
RPL39L	-3913
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF4E	2573
RPL9	3866
EIF4A2	4083
EIF5B	4274
RPS26	9968

---

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

set	Beta oxidation of hexanoyl-CoA to butanoyl-CoA
setSize	5
pANOVA	0.00483
s.dist	-0.728
p.adjustANOVA	0.0163

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HADHA	-10503
HADHB	-9578
ACADS	-8405
ECHS1	-8251
HADH	-2244

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HADHA	-10503
HADHB	-9578
ACADS	-8405
ECHS1	-8251
HADH	-2244

---

Phosphate bond hydrolysis by NUDT proteins

set	Phosphate bond hydrolysis by NUDT proteins
setSize	7
pANOVA	0.000924
s.dist	-0.723
p.adjustANOVA	0.00408

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUDT16	-10676
NUDT1	-9684
NUDT9	-7273
NUDT18	-6823
NUDT5	-6734
NUDT15	-6667
ADPRM	-6357

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUDT16	-10676
NUDT1	-9684
NUDT9	-7273
NUDT18	-6823
NUDT5	-6734
NUDT15	-6667
ADPRM	-6357

---

Cap-dependent Translation Initiation

set	Cap-dependent Translation Initiation
setSize	117
pANOVA	1.23e-41
s.dist	-0.722
p.adjustANOVA	1.39e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
PABPC1	-9845
EIF4EBP1	-9837
RPL36	-9833
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
RPL14	-8455
EIF3B	-8401
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
EIF3H	-7624
RPL6	-7576
EIF3M	-7485
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
EIF2B3	-6948
RPL22	-6931
EIF3E	-6763
RPL26L1	-6583
EIF3C	-5489
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF5	-4985
EIF2B1	-4806
EIF2S2	-4154
RPL39L	-3913
EIF2B4	-3643
EIF2B2	-2625
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF2B5	1907
EIF4E	2573
RPL9	3866
EIF4A2	4083
EIF5B	4274
RPS26	9968

---

Eukaryotic Translation Initiation

set	Eukaryotic Translation Initiation
setSize	117
pANOVA	1.23e-41
s.dist	-0.722
p.adjustANOVA	1.39e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
PABPC1	-9845
EIF4EBP1	-9837
RPL36	-9833
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
RPL14	-8455
EIF3B	-8401
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
EIF3H	-7624
RPL6	-7576
EIF3M	-7485
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
EIF2B3	-6948
RPL22	-6931
EIF3E	-6763
RPL26L1	-6583
EIF3C	-5489
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF5	-4985
EIF2B1	-4806
EIF2S2	-4154
RPL39L	-3913
EIF2B4	-3643
EIF2B2	-2625
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF2B5	1907
EIF4E	2573
RPL9	3866
EIF4A2	4083
EIF5B	4274
RPS26	9968

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	99
pANOVA	1.99e-35
s.dist	-0.721
p.adjustANOVA	1.28e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
TRIB3	-9888
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
EIF2AK4	-9456
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
ATF4	-7607
RPL6	-7576
RPL23A	-7351
RPS3A	-7224
RPS5	-7122
RPL22	-6931
RPL26L1	-6583
CEBPG	-5771
RPL36A	-5184
RPSA	-5038
GCN1	-4661
EIF2S2	-4154
RPL39L	-3913
IMPACT	-2267
CEBPB	-1720
EIF2S3	210
RPS27L	700
EIF2S1	791
ATF2	3662
RPL9	3866
ATF3	4008
DDIT3	4469
ASNS	9540
RPS26	9968

---

Formation of the ternary complex, and subsequently, the 43S complex

set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	4.3e-18
s.dist	-0.701
p.adjustANOVA	1.36e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
RPS25	-9803
EIF3F	-9799
RPS15A	-9791

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPS3	-9752
EIF3L	-9711
RPS18	-9323
EIF3D	-9260
RPS2	-9201
RPS20	-9131
RPS6	-9020
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
EIF3B	-8401
RPS24	-8225
RPS4Y1	-8157
RPS14	-7754
EIF3H	-7624
EIF3M	-7485
RPS3A	-7224
RPS5	-7122
EIF3E	-6763
EIF3C	-5489
RPSA	-5038
EIF2S2	-4154
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
RPS26	9968

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	59
pANOVA	1.07e-19
s.dist	-0.683
p.adjustANOVA	3.98e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
PABPC1	-9845
EIF4EBP1	-9837

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
PABPC1	-9845
EIF4EBP1	-9837
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPS2	-9201
RPS20	-9131
RPS6	-9020
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
EIF3B	-8401
RPS24	-8225
RPS4Y1	-8157
RPS14	-7754
EIF3H	-7624
EIF3M	-7485
RPS3A	-7224
RPS5	-7122
EIF3E	-6763
EIF3C	-5489
EIF4A1	-5296
RPSA	-5038
EIF2S2	-4154
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF4E	2573
EIF4A2	4083
RPS26	9968

---

Translation initiation complex formation

set	Translation initiation complex formation
setSize	58
pANOVA	3.54e-19
s.dist	-0.679
p.adjustANOVA	1.22e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
PABPC1	-9845
RPS25	-9803

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
PABPC1	-9845
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPS2	-9201
RPS20	-9131
RPS6	-9020
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
EIF3B	-8401
RPS24	-8225
RPS4Y1	-8157
RPS14	-7754
EIF3H	-7624
EIF3M	-7485
RPS3A	-7224
RPS5	-7122
EIF3E	-6763
EIF3C	-5489
EIF4A1	-5296
RPSA	-5038
EIF2S2	-4154
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF4E	2573
EIF4A2	4083
RPS26	9968

---

Ribosomal scanning and start codon recognition

set	Ribosomal scanning and start codon recognition
setSize	58
pANOVA	8.84e-19
s.dist	-0.671
p.adjustANOVA	2.94e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10670
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
RPS25	-9803
EIF3F	-9799

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10670
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
EIF3K	-10047
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
EIF3I	-9927
RPS19	-9915
RPS10	-9908
RPS25	-9803
EIF3F	-9799
RPS15A	-9791
RPS3	-9752
EIF3L	-9711
EIF4B	-9688
RPS18	-9323
EIF4G1	-9297
EIF3D	-9260
RPS2	-9201
RPS20	-9131
RPS6	-9020
RPS12	-8857
RPS8	-8796
RPS27A	-8752
EIF3G	-8637
RPS17	-8542
EIF3B	-8401
RPS24	-8225
RPS4Y1	-8157
RPS14	-7754
EIF3H	-7624
EIF3M	-7485
RPS3A	-7224
RPS5	-7122
EIF3E	-6763
EIF3C	-5489
EIF4A1	-5296
RPSA	-5038
EIF5	-4985
EIF2S2	-4154
EIF3A	-1310
EIF2S3	210
EIF3J	295
EIF1AX	542
RPS27L	700
EIF2S1	791
EIF4E	2573
EIF4A2	4083
RPS26	9968

---

SUMO is conjugated to E1 (UBA2:SAE1)

set	SUMO is conjugated to E1 (UBA2:SAE1)
setSize	5
pANOVA	0.00959
s.dist	-0.669
p.adjustANOVA	0.0286

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SUMO3	-10586
SAE1	-10342
SUMO2	-5819
UBA2	-5114
SUMO1	-3909

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SUMO3	-10586
SAE1	-10342
SUMO2	-5819
UBA2	-5114
SUMO1	-3909

---

Fructose metabolism

set	Fructose metabolism
setSize	7
pANOVA	0.00223
s.dist	-0.667
p.adjustANOVA	0.00879

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1B1	-10443
KHK	-9233
SORD	-9157
TKFC	-9037
ALDH1A1	-7011
GLYCTK	-6814
ALDOB	1732

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1B1	-10443
KHK	-9233
SORD	-9157
TKFC	-9037
ALDH1A1	-7011
GLYCTK	-6814
ALDOB	1732

---

Selenoamino acid metabolism

set	Selenoamino acid metabolism
setSize	114
pANOVA	9.63e-35
s.dist	-0.665
p.adjustANOVA	5.99e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
QARS1	-10537
AHCY	-10528
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
QARS1	-10537
AHCY	-10528
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
EEFSEC	-9698
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
PAPSS1	-8635
RPS17	-8542
RPL14	-8455
RPL18	-8392
TXNRD1	-8387
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
SARS1	-7474
RPL23A	-7351
GNMT	-7236
RPS3A	-7224
RPS5	-7122
KARS1	-7027
RPL22	-6931
RPL26L1	-6583
CBS	-6564
SEPHS2	-6487
GSR	-6422
AIMP2	-6319
EPRS1	-5278
RPL36A	-5184
RPSA	-5038
EEF1E1	-5012
RPL39L	-3913
MARS1	-3866
DARS1	-2630
PAPSS2	-2072
HNMT	-1896
NNMT	-951
AIMP1	605
RPS27L	700
RARS1	1304
RPL9	3866
SEPSECS	4292
IARS1	4499
SCLY	4597
LARS1	4750
SECISBP2	4936
INMT	5284
PSTK	7426
RPS26	9968
CTH	10821

---

Prevention of phagosomal-lysosomal fusion

set	Prevention of phagosomal-lysosomal fusion
setSize	9
pANOVA	0.000589
s.dist	-0.661
p.adjustANOVA	0.00278

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10330
RAB7A	-9630
CORO1A	-9088
RPS27A	-8752
UBC	-8746
VPS33B	-8150
UBB	-6271
HGS	-4168
RAB5A	1488

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10330
RAB7A	-9630
CORO1A	-9088
RPS27A	-8752
UBC	-8746
VPS33B	-8150
UBB	-6271
HGS	-4168
RAB5A	1488

---

VLDLR internalisation and degradation

set	VLDLR internalisation and degradation
setSize	15
pANOVA	9.51e-06
s.dist	-0.66
p.adjustANOVA	6.27e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTA	-10570
UBA52	-10330
AP2M1	-10046
AP2S1	-8991
RPS27A	-8752
UBC	-8746
NR1H2	-8528
NR1H3	-7969
MYLIP	-7309
AP2A1	-6891
UBB	-6271
AP2B1	-5407
AP2A2	-5312
CLTC	-4504
VLDLR	3785

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTA	-10570
UBA52	-10330
AP2M1	-10046
AP2S1	-8991
RPS27A	-8752
UBC	-8746
NR1H2	-8528
NR1H3	-7969
MYLIP	-7309
AP2A1	-6891
UBB	-6271
AP2B1	-5407
AP2A2	-5312
CLTC	-4504
VLDLR	3785

---

Nef Mediated CD4 Down-regulation

set	Nef Mediated CD4 Down-regulation
setSize	9
pANOVA	0.000676
s.dist	-0.654
p.adjustANOVA	0.00315

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARF1	-10396
AP2M1	-10046
AP2S1	-8991
LCK	-6908
AP2A1	-6891
AP2B1	-5407
AP2A2	-5312
ATP6V1H	-4897
CD4	-4086

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARF1	-10396
AP2M1	-10046
AP2S1	-8991
LCK	-6908
AP2A1	-6891
AP2B1	-5407
AP2A2	-5312
ATP6V1H	-4897
CD4	-4086

---

Abacavir ADME

set	Abacavir ADME
setSize	5
pANOVA	0.0116
s.dist	0.652
p.adjustANOVA	0.0334

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ABCB1	10094
SLC22A1	10007
ABCG2	6198
ADAL	5770
NT5C2	4354

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ABCB1	10094
SLC22A1	10007
ABCG2	6198
ADAL	5770
NT5C2	4354

---

NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose

set	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
setSize	5
pANOVA	0.0121
s.dist	-0.648
p.adjustANOVA	0.0343

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NR1H2	-8528
NR1H3	-7969
PLIN1	-7419
RXRA	-6247
RXRB	-4474

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NR1H2	-8528
NR1H3	-7969
PLIN1	-7419
RXRA	-6247
RXRB	-4474

---

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

set	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
setSize	9
pANOVA	0.000776
s.dist	-0.647
p.adjustANOVA	0.00352

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10330
AKT1	-10305
RPS27A	-8752
UBC	-8746
ARAP1	-7850
UBB	-6271
PTK6	-4826
DOK1	-4529
CBL	-606

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10330
AKT1	-10305
RPS27A	-8752
UBC	-8746
ARAP1	-7850
UBB	-6271
PTK6	-4826
DOK1	-4529
CBL	-606

---

Regulation of expression of SLITs and ROBOs

set	Regulation of expression of SLITs and ROBOs
setSize	148
pANOVA	3.66e-42
s.dist	-0.647
p.adjustANOVA	5.43e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
PSMB7	-10247
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
PSMC4	-10115

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
PSMB7	-10247
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
PSMC4	-10115
RPS11	-10103
RPS15	-10066
PSMA7	-10064
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
PSMD8	-9933
PSMB6	-9916
RPS19	-9915
RPL12	-9911
RPS10	-9908
PSMC5	-9898
RPL8	-9849
PABPC1	-9845
RPL36	-9833
PSMA6	-9832
RPS25	-9803
PSMB5	-9801
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
PSMD13	-9666
RPL13	-9611
RPL17	-9601
RBX1	-9545
RPL24	-9544
PSMC3	-9414
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
ELOB	-9309
EIF4G1	-9297
RPL11	-9249
RPL36AL	-9235
PSMB1	-9203
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
ADRM1	-8793
RPS27A	-8752
UBC	-8746
ELOC	-8709
PSMA1	-8636
PSMB3	-8558
RPS17	-8542
PSMD3	-8532
RPL14	-8455
RPL18	-8392
PSMD14	-8340
PSMC1	-8336
PSMA2	-8268
RPS24	-8225
RPS4Y1	-8157
PSMB4	-8138
RPL26	-8117
PSMB2	-7916
PSMA5	-7901
RPL21	-7866
RPLP2	-7848
PSMD2	-7818
RPS14	-7754
RPL6	-7576
RPL23A	-7351
DAG1	-7337
RBM8A	-7297
RPS3A	-7224
RPS5	-7122
SEM1	-7005
ZSWIM8	-6941
RPL22	-6931
MAGOH	-6718
RNPS1	-6671
RPL26L1	-6583
ROBO1	-6397
PSMC2	-6389
UBB	-6271
PSMD7	-6229
EIF4A3	-6213
ETF1	-5979
LDB1	-5760
RPL36A	-5184
RPSA	-5038
PSMD1	-5001
PSMA4	-3984
RPL39L	-3913
CASC3	-3705
SLIT1	-3396
NCBP2	-835
RPS27L	700
LHX4	714
GSPT2	886
ROBO3	1474
MAGOHB	2456
PSMC6	3255
USP33	3635
RPL9	3866
GSPT1	3983
PSMD6	4164
PSMD11	4233
PSMD12	4368
UPF3A	5916
NCBP1	6091
COL4A5	6246
PSMA3	6775
UPF3B	8144
UPF2	8372
CUL2	8951
RPS26	9968

---

NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake

set	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
setSize	5
pANOVA	0.0123
s.dist	-0.646
p.adjustANOVA	0.0349

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NR1H2	-8528
NR1H3	-7969
MYLIP	-7309
RXRA	-6247
RXRB	-4474

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NR1H2	-8528
NR1H3	-7969
MYLIP	-7309
RXRA	-6247
RXRB	-4474

---

Formation of xylulose-5-phosphate

set	Formation of xylulose-5-phosphate
setSize	5
pANOVA	0.0127
s.dist	-0.643
p.adjustANOVA	0.0359

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CRYL1	-9876
SORD	-9157
DCXR	-9132
AKR1A1	-8224
XYLB	2017

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CRYL1	-9876
SORD	-9157
DCXR	-9132
AKR1A1	-8224
XYLB	2017

---

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

set	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
setSize	5
pANOVA	0.0137
s.dist	-0.636
p.adjustANOVA	0.0381

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HADHA	-10503
HADHB	-9578
ECHS1	-8251
ACADL	-3410
HADH	-2244

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HADHA	-10503
HADHB	-9578
ECHS1	-8251
ACADL	-3410
HADH	-2244

---

FLT3 signaling by CBL mutants

set	FLT3 signaling by CBL mutants
setSize	7
pANOVA	0.00356
s.dist	-0.636
p.adjustANOVA	0.0128

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FLT3	-10766
UBA52	-10330
RPS27A	-8752
UBC	-8746
UBB	-6271
FLT3LG	-2103
CBL	-606

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FLT3	-10766
UBA52	-10330
RPS27A	-8752
UBC	-8746
UBB	-6271
FLT3LG	-2103
CBL	-606

---

Pentose phosphate pathway

set	Pentose phosphate pathway
setSize	13
pANOVA	7.54e-05
s.dist	-0.634
p.adjustANOVA	0.000435

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPIA	-10200
SHPK	-9890
PGD	-9622
PGLS	-9092
PRPS1	-8782
TKT	-8604
TALDO1	-8525
G6PD	-8444
PGM2	-5864
PRPS2	-4007
DERA	-2879
RPE	-2598
RBKS	499

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPIA	-10200
SHPK	-9890
PGD	-9622
PGLS	-9092
PRPS1	-8782
TKT	-8604
TALDO1	-8525
G6PD	-8444
PGM2	-5864
PRPS2	-4007
DERA	-2879
RPE	-2598
RBKS	499

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	113
pANOVA	1.22e-30
s.dist	-0.626
p.adjustANOVA	6.04e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
PABPC1	-9845
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
PPP2R1A	-8936
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RBM8A	-7297
RPS3A	-7224
RPS5	-7122
RPL22	-6931
MAGOH	-6718
RNPS1	-6671
UPF1	-6632
RPL26L1	-6583
EIF4A3	-6213
ETF1	-5979
PPP2CA	-5631
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
CASC3	-3705
SMG5	-3037
NCBP2	-835
SMG8	315
SMG6	523
RPS27L	700
GSPT2	886
PNRC2	1098
SMG9	1868
MAGOHB	2456
DCP1A	2798
RPL9	3866
GSPT1	3983
UPF3A	5916
NCBP1	6091
SMG1	6582
UPF3B	8144
UPF2	8372
PPP2R2A	8796
RPS26	9968
SMG7	10443

---

Nonsense-Mediated Decay (NMD)

set	Nonsense-Mediated Decay (NMD)
setSize	113
pANOVA	1.22e-30
s.dist	-0.626
p.adjustANOVA	6.04e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
RPL8	-9849
PABPC1	-9845
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
EIF4G1	-9297
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
PPP2R1A	-8936
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
RPL21	-7866
RPLP2	-7848
RPS14	-7754
RPL6	-7576
RPL23A	-7351
RBM8A	-7297
RPS3A	-7224
RPS5	-7122
RPL22	-6931
MAGOH	-6718
RNPS1	-6671
UPF1	-6632
RPL26L1	-6583
EIF4A3	-6213
ETF1	-5979
PPP2CA	-5631
RPL36A	-5184
RPSA	-5038
RPL39L	-3913
CASC3	-3705
SMG5	-3037
NCBP2	-835
SMG8	315
SMG6	523
RPS27L	700
GSPT2	886
PNRC2	1098
SMG9	1868
MAGOHB	2456
DCP1A	2798
RPL9	3866
GSPT1	3983
UPF3A	5916
NCBP1	6091
SMG1	6582
UPF3B	8144
UPF2	8372
PPP2R2A	8796
RPS26	9968
SMG7	10443

---

Protein repair

set	Protein repair
setSize	6
pANOVA	0.00798
s.dist	-0.625
p.adjustANOVA	0.025

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TXN	-9464
PCMT1	-9078
MSRB2	-7807
MSRB1	-7735
MSRA	-7675
MSRB3	1691

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TXN	-9464
PCMT1	-9078
MSRB2	-7807
MSRB1	-7735
MSRA	-7675
MSRB3	1691

---

Ethanol oxidation

set	Ethanol oxidation
setSize	7
pANOVA	0.00423
s.dist	-0.624
p.adjustANOVA	0.0148

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ALDH1B1	-10132
ADH5	-10086
ACSS1	-8465
ALDH2	-7437
ALDH1A1	-7011
ACSS2	-3276
ADH1B	-259

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ALDH1B1	-10132
ADH5	-10086
ACSS1	-8465
ALDH2	-7437
ALDH1A1	-7011
ACSS2	-3276
ADH1B	-259

---

Defective CFTR causes cystic fibrosis

set	Defective CFTR causes cystic fibrosis
setSize	47
pANOVA	1.75e-13
s.dist	-0.621
p.adjustANOVA	3.78e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10330
PSMB7	-10247
PSMC4	-10115
PSMA7	-10064
VCP	-10051
PSMD8	-9933
PSMB6	-9916
PSMC5	-9898
PSMA6	-9832
PSMB5	-9801
PSMD13	-9666
PSMC3	-9414
PSMB1	-9203
RNF185	-9093
OS9	-9024
ADRM1	-8793
RPS27A	-8752
UBC	-8746
PSMA1	-8636
PSMB3	-8558

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10330
PSMB7	-10247
PSMC4	-10115
PSMA7	-10064
VCP	-10051
PSMD8	-9933
PSMB6	-9916
PSMC5	-9898
PSMA6	-9832
PSMB5	-9801
PSMD13	-9666
PSMC3	-9414
PSMB1	-9203
RNF185	-9093
OS9	-9024
ADRM1	-8793
RPS27A	-8752
UBC	-8746
PSMA1	-8636
PSMB3	-8558
PSMD3	-8532
RNF5	-8487
PSMD14	-8340
PSMC1	-8336
PSMA2	-8268
PSMB4	-8138
PSMB2	-7916
PSMA5	-7901
PSMD2	-7818
DERL2	-7769
ERLIN2	-7172
SEM1	-7005
PSMC2	-6389
UBB	-6271
PSMD7	-6229
ERLIN1	-5832
ERLEC1	-5656
DERL3	-5541
PSMD1	-5001
PSMA4	-3984
DERL1	-1582
SEL1L	-1443
PSMC6	3255
PSMD6	4164
PSMD11	4233
PSMD12	4368
PSMA3	6775

---

Formyl peptide receptors bind formyl peptides and many other ligands

set	Formyl peptide receptors bind formyl peptides and many other ligands
setSize	7
pANOVA	0.00458
s.dist	-0.619
p.adjustANOVA	0.0157

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	-10602
ANXA1	-10290
MT-RNR2	-8797
HEBP1	-8773
FPR3	-8705
FPR1	-5019
FPR2	5951

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	-10602
ANXA1	-10290
MT-RNR2	-8797
HEBP1	-8773
FPR3	-8705
FPR1	-5019
FPR2	5951

---

Josephin domain DUBs

set	Josephin domain DUBs
setSize	10
pANOVA	0.00071
s.dist	-0.618
p.adjustANOVA	0.00328

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10330
VCP	-10051
RAD23A	-9329
RPS27A	-8752
UBC	-8746
JOSD2	-7515
RAD23B	-6550
UBB	-6271
JOSD1	-6070
ATXN3	7629

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10330
VCP	-10051
RAD23A	-9329
RPS27A	-8752
UBC	-8746
JOSD2	-7515
RAD23B	-6550
UBB	-6271
JOSD1	-6070
ATXN3	7629

---

Cellular response to starvation

set	Cellular response to starvation
setSize	147
pANOVA	1.1e-37
s.dist	-0.612
p.adjustANOVA	8.5e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10646
RPS7	-10521
RPL39	-10491
RPL35A	-10473
RPL30	-10459
RPL37	-10426
RPL38	-10405
RPL31	-10366
RPL41	-10332
UBA52	-10330
RPL23	-10304
RPL15	-10281
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPL34	-10199
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPL27	-10035
RPS27	-10008
RPS9	-10002
RPL32	-9999
RPS23	-9989
RPL10A	-9984
SEC13	-9966
ATP6V0B	-9962
RPS21	-9960
LAMTOR4	-9953
RPS28	-9944
RPS19	-9915
RPL12	-9911
RPS10	-9908
TRIB3	-9888
ATP6V1F	-9867
RPL8	-9849
RPL36	-9833
RPS25	-9803
RPS15A	-9791
RPL35	-9788
RPS3	-9752
RPL7	-9675
RPL13	-9611
RPL17	-9601
RPL24	-9544
EIF2AK4	-9456
RPLP0	-9377
RPL10	-9362
RPL5	-9357
RPL28	-9336
RPS18	-9323
ATP6V1E2	-9283
RPL11	-9249
RPL36AL	-9235
RPS2	-9201
ATP6V0E1	-9158
RPLP1	-9139
RPS20	-9131
RPL19	-9120
RPL3	-9096
RPL7A	-9085
RPL27A	-9066
RPL4	-9064
RPL13A	-9049
RPS6	-9020
RPL29	-9013
RPL22L1	-8965
RPL18A	-8960
RPS12	-8857
RPS8	-8796
RPS27A	-8752
LAMTOR1	-8714
LAMTOR2	-8684
MIOS	-8565
RPS17	-8542
RPL14	-8455
RPL18	-8392
RPS24	-8225
RPS4Y1	-8157
RPL26	-8117
TCIRG1	-7951
RPL21	-7866
RPLP2	-7848
KPTN	-7836
RPS14	-7754
ATP6V0C	-7718
ATF4	-7607
RPL6	-7576
RPTOR	-7418
RPL23A	-7351
MLST8	-7308
RPS3A	-7224
FNIP2	-7169
ATP6V1G1	-7148
RPS5	-7122
RRAGA	-7120
RPL22	-6931
LAMTOR5	-6806
RPL26L1	-6583
ATP6V1B2	-6324
RHEB	-6170
CEBPG	-5771
SESN2	-5585
WDR59	-5448
RPL36A	-5184
RRAGD	-5133
ATP6V1E1	-5080
RPSA	-5038
WDR24	-5034
ATP6V1H	-4897
ATP6V0E2	-4837
GCN1	-4661
MTOR	-4636
EIF2S2	-4154
ITFG2	-3985
ATP6V1A	-3960
RPL39L	-3913
NPRL2	-3419
BMT2	-3055
IMPACT	-2267
ATP6V1G2	-2192
RRAGB	-2079
CEBPB	-1720
ATP6V1C1	-1700
RRAGC	-1547
SH3BP4	-1510
EIF2S3	210
NPRL3	217
SEH1L	247
SESN1	384
SZT2	521
RPS27L	700
ATP6V1D	763
EIF2S1	791
LAMTOR3	943
ATF2	3662
RPL9	3866
ATF3	4008
DDIT3	4469
SLC38A9	4643
DEPDC5	4715
FNIP1	6169
FLCN	6469
ASNS	9540
ATP6V1C2	9918
RPS26	9968

---

SARS-CoV-2 modulates host translation machinery

set	SARS-CoV-2 modulates host translation machinery
setSize	49
pANOVA	1.44e-13
s.dist	-0.61
p.adjustANOVA	3.15e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPS10	-9908
RPS25	-9803
RPS15A	-9791
RPS3	-9752
GEMIN4	-9674
SNRPD2	-9617

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10521
RPS16	-10239
RPS13	-10235
FAU	-10226
RPS29	-10205
RPS4X	-10160
RPS11	-10103
RPS15	-10066
RPS27	-10008
RPS9	-10002
RPS23	-9989
RPS21	-9960
RPS28	-9944
RPS19	-9915
RPS10	-9908
RPS25	-9803
RPS15A	-9791
RPS3	-9752
GEMIN4	-9674
SNRPD2	-9617
SNRPF	-9616
RPS18	-9323
RPS2	-9201
SNRPB	-9150
RPS20	-9131
RPS6	-9020
RPS12	-8857
RPS8	-8796
RPS27A	-8752
RPS17	-8542
RPS24	-8225
RPS4Y1	-8157
SNRPG	-8016
SNRPE	-7768
RPS14	-7754
RPS3A	-7224
RPS5	-7122
SNRPD3	-6831
RPSA	-5038
GEMIN7	-2546
SNRPD1	-1038
RPS27L	700
GEMIN8	2216
DDX20	3649
GEMIN6	4492
GEMIN2	5346
GEMIN5	6439
SMN1	9024
RPS26	9968

---

Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Abacavir ADME`
## character(0)
## 
## [[1]]$`UP genesets.Chemokine receptors bind chemokines`
## character(0)
## 
## [[1]]$`UP genesets.Expression and translocation of olfactory receptors`
## [1] "OR1I1"  "OR2A5"  "OR2L2"  "OR2M4"  "OR4K17" "OR5K2" 
## 
## [[1]]$`UP genesets.Interaction between L1 and Ankyrins`
## character(0)
## 
## [[1]]$`UP genesets.Miscellaneous substrates`
## [1] "CYP3A43"
## 
## [[1]]$`UP genesets.Olfactory Signaling Pathway`
## [1] "OR1I1"  "OR2A5"  "OR2L2"  "OR2M4"  "OR4K17" "OR5K2" 
## 
## [[1]]$`UP genesets.Sensory Perception`
## [1] "GNAT1"   "OR1I1"   "OR2A5"   "OR2L2"   "OR2M4"   "OR4K17"  "OR5K2"  
## [8] "SLC24A1"
## 
## [[1]]$`UP genesets.Voltage gated Potassium channels`
## [1] "KCNA7" "KCNH7"
## 
## [[1]]$`DOWN genesets.Beta oxidation of hexanoyl-CoA to butanoyl-CoA`
## [1] "ACADS" "ECHS1" "HADH"  "HADHA" "HADHB"
## 
## [[1]]$`DOWN genesets.Cap-dependent Translation Initiation`
##   [1] "EIF1AX"   "EIF2B1"   "EIF2B2"   "EIF2B3"   "EIF2B4"   "EIF2B5"  
##   [7] "EIF2S1"   "EIF2S2"   "EIF2S3"   "EIF3A"    "EIF3B"    "EIF3C"   
##  [13] "EIF3D"    "EIF3E"    "EIF3F"    "EIF3G"    "EIF3H"    "EIF3I"   
##  [19] "EIF3J"    "EIF3K"    "EIF3L"    "EIF3M"    "EIF4A1"   "EIF4A2"  
##  [25] "EIF4B"    "EIF4E"    "EIF4EBP1" "EIF4G1"   "EIF4H"    "EIF5"    
##  [31] "EIF5B"    "FAU"      "PABPC1"   "RPL10"    "RPL10A"   "RPL11"   
##  [37] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
##  [43] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
##  [49] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
##  [55] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
##  [61] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
##  [67] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
##  [73] "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"     "RPL7A"   
##  [79] "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"    "RPS10"   
##  [85] "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"    "RPS15A"  
##  [91] "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"     "RPS20"   
##  [97] "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"    "RPS27"   
## [103] "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"     "RPS3A"   
## [109] "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"     "RPS8"    
## [115] "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Elongation`
##  [1] "EEF1A1"   "EEF1A1P5" "EEF1B2"   "EEF1D"    "EEF1G"    "EEF2"    
##  [7] "FAU"      "RPL10"    "RPL10A"   "RPL11"    "RPL12"    "RPL13"   
## [13] "RPL13A"   "RPL14"    "RPL15"    "RPL17"    "RPL18"    "RPL18A"  
## [19] "RPL19"    "RPL21"    "RPL22"    "RPL22L1"  "RPL23"    "RPL23A"  
## [25] "RPL24"    "RPL26"    "RPL26L1"  "RPL27"    "RPL27A"   "RPL28"   
## [31] "RPL29"    "RPL3"     "RPL30"    "RPL31"    "RPL32"    "RPL34"   
## [37] "RPL35"    "RPL35A"   "RPL36"    "RPL36A"   "RPL36AL"  "RPL37"   
## [43] "RPL37A"   "RPL38"    "RPL39"    "RPL39L"   "RPL4"     "RPL41"   
## [49] "RPL5"     "RPL6"     "RPL7"     "RPL7A"    "RPL8"     "RPL9"    
## [55] "RPLP0"    "RPLP1"    "RPLP2"    "RPS10"    "RPS11"    "RPS12"   
## [61] "RPS13"    "RPS14"    "RPS15"    "RPS15A"   "RPS16"    "RPS17"   
## [67] "RPS18"    "RPS19"    "RPS2"     "RPS20"    "RPS21"    "RPS23"   
## [73] "RPS24"    "RPS25"    "RPS26"    "RPS27"    "RPS27A"   "RPS27L"  
## [79] "RPS28"    "RPS29"    "RPS3"     "RPS3A"    "RPS4X"    "RPS4Y1"  
## [85] "RPS5"     "RPS6"     "RPS7"     "RPS8"     "RPS9"     "RPSA"    
## [91] "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Termination`
##  [1] "APEH"    "ETF1"    "FAU"     "GSPT1"   "GSPT2"   "N6AMT1"  "RPL10"  
##  [8] "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"  
## [15] "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1"
## [22] "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A" 
## [29] "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"  
## [36] "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A" 
## [43] "RPL38"   "RPL39"   "RPL39L"  "RPL4"    "RPL41"   "RPL5"    "RPL6"   
## [50] "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"  
## [57] "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A" 
## [64] "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"  
## [71] "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L" 
## [78] "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"   
## [85] "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"    "TRMT112" "UBA52"  
## 
## [[1]]$`DOWN genesets.Formation of ATP by chemiosmotic coupling`
##  [1] "ATP5F1A" "ATP5F1B" "ATP5F1C" "ATP5F1D" "ATP5F1E" "ATP5MC1" "ATP5MC2"
##  [8] "ATP5MC3" "ATP5ME"  "ATP5MF"  "ATP5MG"  "ATP5MJ"  "ATP5MK"  "ATP5PB" 
## [15] "ATP5PD"  "ATP5PF"  "ATP5PO"  "DMAC2L"  "MT-ATP6" "MT-ATP8"
## 
## [[1]]$`DOWN genesets.Formation of a pool of free 40S subunits`
##  [1] "EIF1AX"  "EIF3A"   "EIF3B"   "EIF3C"   "EIF3D"   "EIF3E"   "EIF3F"  
##  [8] "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"   "EIF3K"   "EIF3L"   "EIF3M"  
## [15] "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A" 
## [22] "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"  
## [29] "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1"
## [36] "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"  
## [43] "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL"
## [50] "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL4"    "RPL41"  
## [57] "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"  
## [64] "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"  
## [71] "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"   
## [78] "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"  
## [85] "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"  
## [92] "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"   
## [99] "UBA52"  
## 
## [[1]]$`DOWN genesets.Formation of annular gap junctions`
##  [1] "ACTB"   "ACTG1"  "AP2M1"  "CLTA"   "CLTB"   "CLTC"   "CLTCL1" "DAB2"  
##  [9] "DNM1"   "DNM2"  
## 
## [[1]]$`DOWN genesets.GTP hydrolysis and joining of the 60S ribosomal subunit`
##   [1] "EIF1AX"  "EIF2S1"  "EIF2S2"  "EIF2S3"  "EIF3A"   "EIF3B"   "EIF3C"  
##   [8] "EIF3D"   "EIF3E"   "EIF3F"   "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"  
##  [15] "EIF3K"   "EIF3L"   "EIF3M"   "EIF4A1"  "EIF4A2"  "EIF4B"   "EIF4E"  
##  [22] "EIF4G1"  "EIF4H"   "EIF5"    "EIF5B"   "FAU"     "RPL10"   "RPL10A" 
##  [29] "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"  
##  [36] "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"  
##  [43] "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"  
##  [50] "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"  
##  [57] "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"  
##  [64] "RPL39"   "RPL39L"  "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"   
##  [71] "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"  
##  [78] "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"  
##  [85] "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"  
##  [92] "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"  
##  [99] "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"   
## [106] "RPS7"    "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Glycosphingolipid transport`
## [1] "ARF1"    "CLN3"    "CPTP"    "ESYT1"   "ESYT2"   "GLTP"    "PLEKHA8"
## 
## [[1]]$`DOWN genesets.L13a-mediated translational silencing of Ceruloplasmin expression`
##   [1] "EIF1AX"  "EIF2S1"  "EIF2S2"  "EIF2S3"  "EIF3A"   "EIF3B"   "EIF3C"  
##   [8] "EIF3D"   "EIF3E"   "EIF3F"   "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"  
##  [15] "EIF3K"   "EIF3L"   "EIF3M"   "EIF4A1"  "EIF4A2"  "EIF4B"   "EIF4E"  
##  [22] "EIF4G1"  "EIF4H"   "FAU"     "PABPC1"  "RPL10"   "RPL10A"  "RPL11"  
##  [29] "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"  
##  [36] "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A" 
##  [43] "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"  
##  [50] "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A" 
##  [57] "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"  
##  [64] "RPL39L"  "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"  
##  [71] "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"  
##  [78] "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"  
##  [85] "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"  
##  [92] "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"  
##  [99] "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"   
## [106] "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Maturation of spike protein_9683686`
## [1] "CANX"   "GANAB"  "MGAT1"  "MOGS"   "PRKCSH"
## 
## [[1]]$`DOWN genesets.Modulation by Mtb of host immune system`
## [1] "B2M"    "MRC1"   "RPS27A" "TLR2"   "UBA52"  "UBB"    "UBC"   
## 
## [[1]]$`DOWN genesets.Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)`
##  [1] "EIF4G1"  "ETF1"    "FAU"     "GSPT1"   "GSPT2"   "NCBP1"   "NCBP2"  
##  [8] "PABPC1"  "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A" 
## [15] "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"  
## [22] "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1"
## [29] "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"  
## [36] "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL"
## [43] "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL4"    "RPL41"  
## [50] "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"  
## [57] "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"  
## [64] "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"   
## [71] "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"  
## [78] "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"  
## [85] "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"   
## [92] "UBA52"   "UPF1"   
## 
## [[1]]$`DOWN genesets.Peptide chain elongation`
##  [1] "EEF1A1"  "EEF2"    "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"  
##  [8] "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A" 
## [15] "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"  
## [22] "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"   
## [29] "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"  
## [36] "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L" 
## [43] "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"   
## [50] "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"  
## [57] "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"  
## [64] "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"  
## [71] "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"   
## [78] "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"   
## [85] "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Phosphate bond hydrolysis by NUDT proteins`
## [1] "ADPRM"  "NUDT1"  "NUDT15" "NUDT16" "NUDT18" "NUDT5"  "NUDT9" 
## 
## [[1]]$`DOWN genesets.SARS-CoV-1 modulates host translation machinery`
##  [1] "EEF1A1"  "FAU"     "HNRNPA1" "RPS10"   "RPS11"   "RPS12"   "RPS13"  
##  [8] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
## [15] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
## [22] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
## [29] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
## [36] "RPSA"   
## 
## [[1]]$`DOWN genesets.SRP-dependent cotranslational protein targeting to membrane`
##   [1] "DDOST"   "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"  
##   [8] "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"  
##  [15] "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"  
##  [22] "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"  
##  [29] "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A" 
##  [36] "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL4"   
##  [43] "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"   
##  [50] "RPLP0"   "RPLP1"   "RPLP2"   "RPN1"    "RPN2"    "RPS10"   "RPS11"  
##  [57] "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"  
##  [64] "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"  
##  [71] "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"  
##  [78] "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"   
##  [85] "RPS8"    "RPS9"    "RPSA"    "SEC11A"  "SEC11C"  "SEC61A1" "SEC61A2"
##  [92] "SEC61B"  "SEC61G"  "SPCS1"   "SPCS2"   "SPCS3"   "SRP14"   "SRP19"  
##  [99] "SRP54"   "SRP68"   "SRP72"   "SRP9"    "SRPRA"   "SRPRB"   "SSR1"   
## [106] "SSR2"    "SSR3"    "SSR4"    "TRAM1"   "UBA52"  
## 
## [[1]]$`DOWN genesets.Selenocysteine synthesis`
##  [1] "EEFSEC"   "FAU"      "PSTK"     "RPL10"    "RPL10A"   "RPL11"   
##  [7] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
## [13] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
## [19] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
## [25] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
## [31] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
## [37] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
## [43] "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"     "RPL7A"   
## [49] "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"    "RPS10"   
## [55] "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"    "RPS15A"  
## [61] "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"     "RPS20"   
## [67] "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"    "RPS27"   
## [73] "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"     "RPS3A"   
## [79] "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"     "RPS8"    
## [85] "RPS9"     "RPSA"     "SARS1"    "SECISBP2" "SEPHS2"   "SEPSECS" 
## [91] "UBA52"   
## 
## [[1]]$`DOWN genesets.Sulfide oxidation to sulfate`
## [1] "ETHE1"    "SLC25A10" "SUOX"     "TST"      "TSTD1"   
## 
## [[1]]$`DOWN genesets.Viral mRNA Translation`
##  [1] "DNAJC3"  "FAU"     "GRSF1"   "RPL10"   "RPL10A"  "RPL11"   "RPL12"  
##  [8] "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A" 
## [15] "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"  
## [22] "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"   
## [29] "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"  
## [36] "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L" 
## [43] "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"   
## [50] "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"  
## [57] "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"  
## [64] "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"  
## [71] "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"   
## [78] "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"   
## [85] "RPS9"    "RPSA"    "UBA52"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report