date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.1120300
A1BG -0.0355391
A1BG-AS1 0.2045288
A1CF 0.4927809
A2M 3.2175106
A2M-AS1 2.8044553

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
RUNX1 regulates transcription of genes involved in BCR signaling 6 1.00e-03 0.776 2.58e-02
CD163 mediating an anti-inflammatory response 9 7.14e-05 0.764 5.18e-03
Formation of xylulose-5-phosphate 5 6.86e-03 -0.698 8.33e-02
Defective LFNG causes SCDO3 5 8.30e-03 -0.682 9.11e-02
Fructose metabolism 7 1.81e-03 -0.681 3.72e-02
Formation of the ureteric bud 5 1.09e-02 0.658 1.07e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.31e-03 -0.656 2.94e-02
LTC4-CYSLTR mediated IL4 production 5 1.23e-02 -0.647 1.16e-01
Fructose catabolism 5 1.75e-02 -0.614 1.47e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.85e-03 0.602 7.63e-02
MECP2 regulates transcription of neuronal ligands 5 2.00e-02 -0.601 1.56e-01
Defects in biotin (Btn) metabolism 8 4.16e-03 -0.585 6.37e-02
Alternative complement activation 5 2.39e-02 -0.583 1.72e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 9.76e-03 -0.564 9.98e-02
Phenylalanine metabolism 5 3.07e-02 -0.558 1.98e-01
MET activates RAP1 and RAC1 10 2.50e-03 0.552 4.61e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 2.66e-03 0.549 4.79e-02
MET activates PI3K/AKT signaling 5 3.62e-02 0.541 2.17e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.33e-02 -0.540 1.21e-01
Reversible hydration of carbon dioxide 8 1.00e-02 0.526 1.01e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.57e-02 0.526 1.80e-01
Propionyl-CoA catabolism 5 4.44e-02 -0.519 2.43e-01
Synthesis of PG 8 1.16e-02 -0.515 1.11e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 4.66e-02 -0.514 2.50e-01
Sulfide oxidation to sulfate 5 4.66e-02 -0.514 2.50e-01
Defective binding of VWF variant to GPIb:IX:V 7 1.90e-02 0.512 1.54e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.90e-02 0.512 1.54e-01
PTK6 Regulates Cell Cycle 6 3.44e-02 -0.499 2.10e-01
Activation of NOXA and translocation to mitochondria 5 5.67e-02 -0.492 2.75e-01
Molybdenum cofactor biosynthesis 6 3.85e-02 -0.488 2.26e-01
IFNG signaling activates MAPKs 8 1.74e-02 0.486 1.47e-01
Carnitine shuttle 12 3.65e-03 -0.485 6.00e-02
Unwinding of DNA 12 3.73e-03 -0.483 6.01e-02
Type I hemidesmosome assembly 8 1.85e-02 -0.481 1.53e-01
Signal attenuation 9 1.25e-02 0.481 1.17e-01
Creation of C4 and C2 activators 71 3.38e-12 -0.477 3.26e-09
Initial triggering of complement 79 3.69e-13 -0.473 7.13e-10
Translocation of ZAP-70 to Immunological synapse 24 6.15e-05 -0.472 4.75e-03
Estrogen-stimulated signaling through PRKCZ 6 4.68e-02 0.469 2.50e-01
Classical antibody-mediated complement activation 69 1.80e-11 -0.468 1.16e-08
POLB-Dependent Long Patch Base Excision Repair 8 2.37e-02 -0.462 1.72e-01
Diseases of Base Excision Repair 5 7.49e-02 -0.460 3.21e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 3.52e-02 0.460 2.13e-01
Biotin transport and metabolism 11 8.43e-03 -0.459 9.20e-02
Formation of the active cofactor, UDP-glucuronate 5 7.78e-02 0.455 3.27e-01
Modulation by Mtb of host immune system 7 3.75e-02 0.454 2.22e-01
Phosphorylation of Emi1 6 5.47e-02 -0.453 2.67e-01
Erythrocytes take up carbon dioxide and release oxygen 11 9.31e-03 0.453 9.72e-02
O2/CO2 exchange in erythrocytes 11 9.31e-03 0.453 9.72e-02
Organic anion transporters 7 3.88e-02 -0.451 2.27e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
RUNX1 regulates transcription of genes involved in BCR signaling 6 1.00e-03 0.776000 2.58e-02
CD163 mediating an anti-inflammatory response 9 7.14e-05 0.764000 5.18e-03
Formation of xylulose-5-phosphate 5 6.86e-03 -0.698000 8.33e-02
Defective LFNG causes SCDO3 5 8.30e-03 -0.682000 9.11e-02
Fructose metabolism 7 1.81e-03 -0.681000 3.72e-02
Formation of the ureteric bud 5 1.09e-02 0.658000 1.07e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.31e-03 -0.656000 2.94e-02
LTC4-CYSLTR mediated IL4 production 5 1.23e-02 -0.647000 1.16e-01
Fructose catabolism 5 1.75e-02 -0.614000 1.47e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.85e-03 0.602000 7.63e-02
MECP2 regulates transcription of neuronal ligands 5 2.00e-02 -0.601000 1.56e-01
Defects in biotin (Btn) metabolism 8 4.16e-03 -0.585000 6.37e-02
Alternative complement activation 5 2.39e-02 -0.583000 1.72e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 9.76e-03 -0.564000 9.98e-02
Phenylalanine metabolism 5 3.07e-02 -0.558000 1.98e-01
MET activates RAP1 and RAC1 10 2.50e-03 0.552000 4.61e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 2.66e-03 0.549000 4.79e-02
MET activates PI3K/AKT signaling 5 3.62e-02 0.541000 2.17e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.33e-02 -0.540000 1.21e-01
Reversible hydration of carbon dioxide 8 1.00e-02 0.526000 1.01e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.57e-02 0.526000 1.80e-01
Propionyl-CoA catabolism 5 4.44e-02 -0.519000 2.43e-01
Synthesis of PG 8 1.16e-02 -0.515000 1.11e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 4.66e-02 -0.514000 2.50e-01
Sulfide oxidation to sulfate 5 4.66e-02 -0.514000 2.50e-01
Defective binding of VWF variant to GPIb:IX:V 7 1.90e-02 0.512000 1.54e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.90e-02 0.512000 1.54e-01
PTK6 Regulates Cell Cycle 6 3.44e-02 -0.499000 2.10e-01
Activation of NOXA and translocation to mitochondria 5 5.67e-02 -0.492000 2.75e-01
Molybdenum cofactor biosynthesis 6 3.85e-02 -0.488000 2.26e-01
IFNG signaling activates MAPKs 8 1.74e-02 0.486000 1.47e-01
Carnitine shuttle 12 3.65e-03 -0.485000 6.00e-02
Unwinding of DNA 12 3.73e-03 -0.483000 6.01e-02
Type I hemidesmosome assembly 8 1.85e-02 -0.481000 1.53e-01
Signal attenuation 9 1.25e-02 0.481000 1.17e-01
Creation of C4 and C2 activators 71 3.38e-12 -0.477000 3.26e-09
Initial triggering of complement 79 3.69e-13 -0.473000 7.13e-10
Translocation of ZAP-70 to Immunological synapse 24 6.15e-05 -0.472000 4.75e-03
Estrogen-stimulated signaling through PRKCZ 6 4.68e-02 0.469000 2.50e-01
Classical antibody-mediated complement activation 69 1.80e-11 -0.468000 1.16e-08
POLB-Dependent Long Patch Base Excision Repair 8 2.37e-02 -0.462000 1.72e-01
Diseases of Base Excision Repair 5 7.49e-02 -0.460000 3.21e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 3.52e-02 0.460000 2.13e-01
Biotin transport and metabolism 11 8.43e-03 -0.459000 9.20e-02
Formation of the active cofactor, UDP-glucuronate 5 7.78e-02 0.455000 3.27e-01
Modulation by Mtb of host immune system 7 3.75e-02 0.454000 2.22e-01
Phosphorylation of Emi1 6 5.47e-02 -0.453000 2.67e-01
Erythrocytes take up carbon dioxide and release oxygen 11 9.31e-03 0.453000 9.72e-02
O2/CO2 exchange in erythrocytes 11 9.31e-03 0.453000 9.72e-02
Organic anion transporters 7 3.88e-02 -0.451000 2.27e-01
Scavenging of heme from plasma 70 1.19e-10 -0.445000 5.75e-08
Synthesis of PI 5 8.66e-02 -0.443000 3.42e-01
ATF6 (ATF6-alpha) activates chaperones 12 8.08e-03 0.442000 8.98e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 8.75e-02 -0.441000 3.44e-01
Aflatoxin activation and detoxification 14 4.27e-03 -0.441000 6.39e-02
Cellular hexose transport 14 4.42e-03 -0.439000 6.53e-02
Eicosanoids 6 6.35e-02 0.437000 2.96e-01
Regulation of IFNG signaling 14 4.73e-03 0.436000 6.72e-02
Acetylcholine regulates insulin secretion 9 2.38e-02 -0.435000 1.72e-01
HDR through MMEJ (alt-NHEJ) 12 9.19e-03 -0.434000 9.70e-02
Glycogen synthesis 11 1.28e-02 0.433000 1.19e-01
Neurotoxicity of clostridium toxins 9 2.50e-02 -0.431000 1.78e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 6.89e-02 -0.429000 3.09e-01
Digestion 5 9.68e-02 0.429000 3.67e-01
Signaling by MST1 5 9.75e-02 -0.428000 3.69e-01
Platelet Adhesion to exposed collagen 16 3.09e-03 0.427000 5.35e-02
Protein repair 6 7.07e-02 0.426000 3.15e-01
Phenylalanine and tyrosine metabolism 9 2.78e-02 -0.423000 1.86e-01
Biosynthesis of Lipoxins (LX) 6 7.63e-02 0.418000 3.23e-01
Glucuronidation 9 3.24e-02 0.412000 2.02e-01
Regulation of CDH11 mRNA translation by microRNAs 8 4.43e-02 -0.411000 2.43e-01
Regulation of NPAS4 mRNA translation 8 4.43e-02 -0.411000 2.43e-01
RHOT1 GTPase cycle 5 1.13e-01 0.409000 3.91e-01
Regulation of PTEN localization 9 3.36e-02 0.409000 2.08e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 4.88e-03 0.406000 6.74e-02
Leading Strand Synthesis 14 8.80e-03 -0.404000 9.44e-02
Polymerase switching 14 8.80e-03 -0.404000 9.44e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.18e-02 0.403000 1.12e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 8.85e-02 -0.402000 3.46e-01
Processive synthesis on the lagging strand 15 7.22e-03 -0.401000 8.45e-02
DNA strand elongation 32 9.48e-05 -0.399000 5.78e-03
Coenzyme A biosynthesis 7 6.78e-02 -0.399000 3.08e-01
Removal of the Flap Intermediate 14 9.93e-03 -0.398000 1.00e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.97e-02 0.396000 2.28e-01
CD22 mediated BCR regulation 58 2.39e-07 -0.392000 5.14e-05
Attachment of GPI anchor to uPAR 7 7.30e-02 -0.391000 3.18e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.91e-02 -0.391000 1.54e-01
Negative feedback regulation of MAPK pathway 6 9.82e-02 0.390000 3.70e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.95e-02 0.390000 1.54e-01
Transport of connexons to the plasma membrane 12 1.95e-02 0.390000 1.54e-01
Activation of the phototransduction cascade 8 5.65e-02 0.389000 2.75e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 7.48e-02 -0.389000 3.21e-01
SARS-CoV-2 modulates autophagy 11 2.55e-02 -0.389000 1.79e-01
LGI-ADAM interactions 9 4.45e-02 -0.387000 2.43e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.86e-03 0.383000 6.17e-02
Sperm Motility And Taxes 6 1.05e-01 -0.382000 3.82e-01
Phosphorylation of CD3 and TCR zeta chains 27 6.38e-04 -0.380000 2.03e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 1.43e-01 0.378000 4.35e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 1.09e-01 0.378000 3.84e-01
Glycosphingolipid transport 7 8.43e-02 -0.377000 3.38e-01
PD-1 signaling 28 6.01e-04 -0.375000 1.97e-02
Mitochondrial RNA degradation 25 1.22e-03 0.374000 2.89e-02
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 1.02e-02 0.371000 1.02e-01
Hedgehog ligand biogenesis 47 1.12e-05 0.370000 1.14e-03
Olfactory Signaling Pathway 61 5.78e-07 0.370000 9.30e-05
FCGR activation 76 2.69e-08 -0.369000 8.65e-06
Expression and translocation of olfactory receptors 56 1.82e-06 0.369000 2.35e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 2.52e-04 -0.368000 1.13e-02
Regulation of NPAS4 gene expression 11 3.55e-02 -0.366000 2.13e-01
NFE2L2 regulates pentose phosphate pathway genes 8 7.45e-02 0.364000 3.21e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.89e-03 0.364000 6.17e-02
Synthesis of PIPs at the Golgi membrane 16 1.26e-02 -0.360000 1.18e-01
Synthesis of PC 23 2.88e-03 0.359000 5.16e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 6.30e-02 0.358000 2.96e-01
GABA synthesis, release, reuptake and degradation 12 3.19e-02 -0.358000 2.01e-01
NR1H2 and NR1H3-mediated signaling 39 1.11e-04 -0.358000 6.22e-03
Defects of platelet adhesion to exposed collagen 8 8.02e-02 0.357000 3.31e-01
Estrogen biosynthesis 5 1.68e-01 0.356000 4.70e-01
ROBO receptors bind AKAP5 7 1.04e-01 -0.355000 3.80e-01
Spry regulation of FGF signaling 16 1.39e-02 0.355000 1.25e-01
Uptake of dietary cobalamins into enterocytes 6 1.32e-01 -0.355000 4.24e-01
CHL1 interactions 8 8.23e-02 0.355000 3.34e-01
Lipophagy 7 1.04e-01 0.355000 3.82e-01
Role of phospholipids in phagocytosis 88 9.53e-09 -0.354000 3.68e-06
Nucleotide biosynthesis 12 3.40e-02 -0.353000 2.10e-01
Hh mutants are degraded by ERAD 42 8.23e-05 0.351000 5.68e-03
Hh mutants abrogate ligand secretion 43 7.24e-05 0.350000 5.18e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 9.09e-05 0.349000 5.78e-03
Lagging Strand Synthesis 20 7.16e-03 -0.347000 8.44e-02
Phosphate bond hydrolysis by NTPDase proteins 5 1.79e-01 -0.347000 4.82e-01
PINK1-PRKN Mediated Mitophagy 31 8.84e-04 0.345000 2.39e-02
Acetylcholine Neurotransmitter Release Cycle 11 4.82e-02 -0.344000 2.54e-01
Post-transcriptional silencing by small RNAs 7 1.18e-01 -0.341000 3.98e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 1.21e-01 -0.339000 4.04e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 5.19e-02 -0.338000 2.59e-01
Nectin/Necl trans heterodimerization 5 1.91e-01 -0.338000 5.04e-01
Tandem pore domain potassium channels 5 1.91e-01 -0.338000 5.04e-01
RHOBTB1 GTPase cycle 23 5.09e-03 0.337000 6.87e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 4.11e-04 0.336000 1.54e-02
Myoclonic epilepsy of Lafora 8 1.01e-01 0.335000 3.75e-01
Role of LAT2/NTAL/LAB on calcium mobilization 77 4.10e-07 -0.334000 7.20e-05
Degradation of GLI1 by the proteasome 46 9.57e-05 0.332000 5.78e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 2.01e-04 0.332000 9.95e-03
Scavenging by Class A Receptors 14 3.20e-02 0.331000 2.01e-01
Synthesis of PIPs at the ER membrane 5 2.02e-01 -0.329000 5.14e-01
G1/S-Specific Transcription 29 2.17e-03 -0.329000 4.17e-02
Sodium/Proton exchangers 7 1.32e-01 -0.329000 4.24e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.05e-02 -0.328000 2.29e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 4.58e-03 -0.328000 6.55e-02
MET receptor recycling 9 8.91e-02 0.327000 3.46e-01
Toxicity of botulinum toxin type D (botD) 5 2.07e-01 -0.326000 5.19e-01
Toxicity of botulinum toxin type F (botF) 5 2.07e-01 -0.326000 5.19e-01
Acyl chain remodelling of PI 10 7.52e-02 0.325000 3.21e-01
Maturation of hRSV A proteins 13 4.32e-02 0.324000 2.40e-01
Disorders of Developmental Biology 12 5.21e-02 -0.324000 2.59e-01
Disorders of Nervous System Development 12 5.21e-02 -0.324000 2.59e-01
Loss of function of MECP2 in Rett syndrome 12 5.21e-02 -0.324000 2.59e-01
Pervasive developmental disorders 12 5.21e-02 -0.324000 2.59e-01
Activation of NF-kappaB in B cells 54 4.06e-05 0.323000 3.56e-03
Resolution of Abasic Sites (AP sites) 38 5.95e-04 -0.322000 1.97e-02
Insulin receptor recycling 24 6.45e-03 0.321000 8.04e-02
Complement cascade 100 3.19e-08 -0.320000 8.79e-06
Vif-mediated degradation of APOBEC3G 41 4.05e-04 0.319000 1.54e-02
Axonal growth inhibition (RHOA activation) 7 1.44e-01 0.319000 4.35e-01
p75NTR regulates axonogenesis 7 1.44e-01 0.319000 4.35e-01
Negative regulation of FGFR3 signaling 21 1.16e-02 0.318000 1.11e-01
Degradation of GLI2 by the proteasome 45 2.23e-04 0.318000 1.05e-02
Regulation of Apoptosis 40 5.03e-04 0.318000 1.76e-02
NFE2L2 regulating ER-stress associated genes 5 2.21e-01 0.316000 5.37e-01
Interleukin-18 signaling 6 1.81e-01 0.315000 4.85e-01
Eicosanoid ligand-binding receptors 13 4.92e-02 -0.315000 2.55e-01
NPAS4 regulates expression of target genes 16 2.96e-02 0.314000 1.94e-01
Defective pyroptosis 27 4.79e-03 -0.314000 6.74e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.23e-02 -0.313000 2.38e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.29e-02 -0.313000 2.39e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 2.27e-01 0.312000 5.38e-01
Josephin domain DUBs 10 8.75e-02 0.312000 3.44e-01
PCNA-Dependent Long Patch Base Excision Repair 21 1.34e-02 -0.312000 1.22e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 2.28e-01 0.312000 5.38e-01
GLI3 is processed to GLI3R by the proteasome 46 2.57e-04 0.311000 1.13e-02
Infection with Mycobacterium tuberculosis 26 5.98e-03 0.311000 7.71e-02
RHO GTPases activate IQGAPs 25 7.16e-03 0.311000 8.44e-02
SOS-mediated signalling 7 1.55e-01 0.311000 4.53e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 1.88e-01 -0.310000 5.02e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 3.19e-02 -0.310000 2.01e-01
Glycerophospholipid catabolism 6 1.90e-01 -0.309000 5.03e-01
Gluconeogenesis 19 1.98e-02 -0.309000 1.56e-01
Aggrephagy 34 1.84e-03 0.309000 3.74e-02
Crosslinking of collagen fibrils 15 3.86e-02 0.308000 2.26e-01
Chemokine receptors bind chemokines 39 9.04e-04 0.307000 2.39e-02
Folding of actin by CCT/TriC 10 9.32e-02 0.307000 3.59e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 2.37e-01 0.305000 5.50e-01
Regulation of Complement cascade 96 2.38e-07 -0.305000 5.14e-05
RHO GTPases Activate ROCKs 18 2.52e-02 0.305000 1.79e-01
Suppression of phagosomal maturation 12 6.76e-02 0.305000 3.08e-01
ARMS-mediated activation 6 1.98e-01 0.304000 5.13e-01
Defective CFTR causes cystic fibrosis 47 3.14e-04 0.304000 1.30e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 1.66e-01 -0.303000 4.67e-01
Post-chaperonin tubulin folding pathway 18 2.62e-02 0.303000 1.82e-01
Binding and Uptake of Ligands by Scavenger Receptors 94 4.01e-07 -0.302000 7.20e-05
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 2.42e-01 -0.302000 5.57e-01
DNA replication initiation 8 1.40e-01 -0.301000 4.33e-01
Passive transport by Aquaporins 6 2.02e-01 0.301000 5.14e-01
CS/DS degradation 9 1.18e-01 -0.301000 3.98e-01
STAT5 activation downstream of FLT3 ITD mutants 9 1.18e-01 0.301000 3.98e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.33e-02 0.301000 1.71e-01
Sema4D induced cell migration and growth-cone collapse 19 2.33e-02 0.300000 1.71e-01
Relaxin receptors 5 2.46e-01 0.299000 5.61e-01
Regulated proteolysis of p75NTR 11 8.63e-02 0.299000 3.42e-01
RHOBTB GTPase Cycle 35 2.28e-03 0.298000 4.33e-02
PI-3K cascade:FGFR3 10 1.03e-01 0.298000 3.79e-01
Hyaluronan uptake and degradation 12 7.44e-02 -0.297000 3.21e-01
Hyaluronan metabolism 16 3.97e-02 -0.297000 2.28e-01
RHOBTB2 GTPase cycle 23 1.39e-02 0.296000 1.25e-01
Cytosolic iron-sulfur cluster assembly 13 6.47e-02 -0.296000 2.99e-01
TGFBR3 expression 20 2.25e-02 -0.295000 1.68e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 2.58e-03 0.294000 4.69e-02
Phosphate bond hydrolysis by NUDT proteins 7 1.79e-01 0.294000 4.82e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.41e-04 0.293000 1.58e-02
Activation of AMPK downstream of NMDARs 20 2.34e-02 0.293000 1.71e-01
Role of second messengers in netrin-1 signaling 6 2.15e-01 -0.293000 5.29e-01
Physiological factors 9 1.29e-01 0.292000 4.21e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.10e-01 0.292000 3.84e-01
Response of Mtb to phagocytosis 22 1.87e-02 0.290000 1.53e-01
Downstream signaling events of B Cell Receptor (BCR) 68 3.60e-05 0.290000 3.31e-03
Polymerase switching on the C-strand of the telomere 26 1.08e-02 -0.289000 1.07e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.40e-03 0.288000 3.10e-02
Activation of the pre-replicative complex 32 4.84e-03 -0.288000 6.74e-02
Acetylcholine binding and downstream events 5 2.66e-01 -0.287000 5.85e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.66e-01 -0.287000 5.85e-01
Response to metal ions 6 2.23e-01 0.287000 5.38e-01
FCGR3A-mediated IL10 synthesis 99 8.32e-07 -0.287000 1.19e-04
RUNX1 regulates expression of components of tight junctions 5 2.68e-01 0.286000 5.86e-01
COPI-independent Golgi-to-ER retrograde traffic 45 8.95e-04 0.286000 2.39e-02
Degradation of DVL 43 1.18e-03 0.286000 2.84e-02
GPVI-mediated activation cascade 33 4.48e-03 0.286000 6.53e-02
Activation of PUMA and translocation to mitochondria 9 1.38e-01 -0.286000 4.29e-01
Vpu mediated degradation of CD4 39 2.05e-03 0.285000 4.04e-02
FCERI mediated MAPK activation 93 2.08e-06 -0.285000 2.51e-04
ABC transporter disorders 60 1.39e-04 0.284000 7.22e-03
HDL remodeling 6 2.28e-01 -0.284000 5.38e-01
Ubiquitin-dependent degradation of Cyclin D 39 2.18e-03 0.284000 4.17e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 4.15e-04 0.283000 1.54e-02
Signaling by activated point mutants of FGFR1 5 2.73e-01 0.283000 5.96e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.62e-03 0.283000 9.92e-02
Prolonged ERK activation events 13 7.82e-02 0.282000 3.28e-01
tRNA processing in the mitochondrion 24 1.69e-02 0.282000 1.44e-01
TNFR1-mediated ceramide production 6 2.32e-01 -0.282000 5.43e-01
Ketone body metabolism 8 1.68e-01 -0.281000 4.70e-01
Regulation of RAS by GAPs 55 3.17e-04 0.281000 1.30e-02
Negative regulation of NOTCH4 signaling 44 1.30e-03 0.280000 2.94e-02
Degradation of AXIN 42 1.72e-03 0.279000 3.64e-02
Mitochondrial Uncoupling 6 2.38e-01 -0.278000 5.51e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 2.82e-01 0.278000 6.03e-01
Maple Syrup Urine Disease 5 2.82e-01 0.278000 6.03e-01
FCERI mediated Ca+2 mobilization 92 4.15e-06 -0.278000 4.45e-04
Generation of second messenger molecules 38 3.10e-03 -0.277000 5.35e-02
Regulation of ornithine decarboxylase (ODC) 38 3.10e-03 0.277000 5.35e-02
Defective GALNT3 causes HFTC 9 1.50e-01 -0.277000 4.46e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 2.84e-01 0.276000 6.05e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 2.06e-01 -0.276000 5.19e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.45e-02 0.275000 3.21e-01
Synthesis of Ketone Bodies 6 2.43e-01 -0.275000 5.58e-01
RSK activation 7 2.07e-01 0.275000 5.19e-01
Malate-aspartate shuttle 8 1.78e-01 -0.275000 4.82e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 3.35e-03 0.275000 5.58e-02
Platelet Aggregation (Plug Formation) 30 9.13e-03 0.275000 9.69e-02
Regulation of FZD by ubiquitination 16 5.74e-02 0.274000 2.76e-01
RUNX3 regulates p14-ARF 10 1.33e-01 0.274000 4.24e-01
Regulation of PTEN stability and activity 55 4.33e-04 0.274000 1.58e-02
Regulation of RUNX3 expression and activity 45 1.49e-03 0.274000 3.27e-02
Defects in vitamin and cofactor metabolism 21 3.01e-02 -0.273000 1.96e-01
Frs2-mediated activation 11 1.17e-01 0.273000 3.98e-01
Sema4D in semaphorin signaling 22 2.75e-02 0.272000 1.84e-01
Glycogen metabolism 21 3.21e-02 0.270000 2.02e-01
RHO GTPases activate KTN1 11 1.22e-01 0.270000 4.07e-01
Netrin mediated repulsion signals 5 2.97e-01 -0.269000 6.18e-01
Transcription of E2F targets under negative control by DREAM complex 19 4.28e-02 -0.268000 2.39e-01
Asymmetric localization of PCP proteins 49 1.16e-03 0.268000 2.84e-02
Synthesis of PE 12 1.08e-01 0.268000 3.84e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 4.04e-04 0.266000 1.54e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 6.57e-02 0.266000 3.03e-01
Negative regulation of FGFR4 signaling 22 3.10e-02 0.266000 1.99e-01
Chaperone Mediated Autophagy 20 3.99e-02 0.265000 2.28e-01
TNFs bind their physiological receptors 25 2.18e-02 -0.265000 1.65e-01
Maturation of nucleoprotein 9694631 15 7.57e-02 0.265000 3.22e-01
Aryl hydrocarbon receptor signalling 6 2.61e-01 0.265000 5.81e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 9.65e-03 0.264000 9.92e-02
Arachidonate production from DAG 5 3.06e-01 -0.264000 6.23e-01
Degradation of cysteine and homocysteine 13 1.00e-01 -0.263000 3.75e-01
SCF-beta-TrCP mediated degradation of Emi1 42 3.17e-03 0.263000 5.42e-02
TGFBR3 regulates TGF-beta signaling 8 1.98e-01 -0.263000 5.13e-01
CDC6 association with the ORC:origin complex 8 1.98e-01 -0.263000 5.13e-01
Signaling by FLT3 ITD and TKD mutants 15 7.86e-02 0.262000 3.29e-01
Zinc influx into cells by the SLC39 gene family 9 1.74e-01 0.262000 4.75e-01
ADP signalling through P2Y purinoceptor 12 18 5.45e-02 0.262000 2.67e-01
Maturation of nucleoprotein 9683610 11 1.34e-01 0.261000 4.24e-01
Beta-catenin phosphorylation cascade 17 6.35e-02 0.260000 2.96e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 8.25e-02 -0.259000 3.34e-01
Rap1 signalling 14 9.39e-02 0.259000 3.61e-01
Negative regulation of MET activity 18 5.79e-02 0.258000 2.78e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 2.55e-02 0.258000 1.79e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 1.08e-01 -0.257000 3.84e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 2.75e-01 0.257000 5.97e-01
ER-Phagosome pathway 75 1.18e-04 0.257000 6.32e-03
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 1.24e-01 0.257000 4.12e-01
Negative regulation of FGFR1 signaling 25 2.63e-02 0.257000 1.82e-01
AKT phosphorylates targets in the nucleus 9 1.83e-01 -0.256000 4.90e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.41e-01 0.256000 4.33e-01
Sodium-coupled phosphate cotransporters 5 3.21e-01 -0.256000 6.36e-01
Base Excision Repair 57 8.28e-04 -0.256000 2.32e-02
Mitophagy 38 6.32e-03 0.256000 7.93e-02
Gap junction assembly 17 6.81e-02 0.256000 3.08e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.26e-01 0.255000 4.16e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 3.16e-02 0.254000 2.01e-01
Anchoring fibril formation 10 1.66e-01 0.253000 4.67e-01
Formation of axial mesoderm 6 2.83e-01 0.253000 6.05e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.29e-01 0.252000 6.42e-01
Stabilization of p53 43 4.23e-03 0.252000 6.38e-02
Regulation of MITF-M-dependent genes involved in apoptosis 16 8.11e-02 -0.252000 3.33e-01
Molecules associated with elastic fibres 26 2.65e-02 -0.251000 1.82e-01
Metabolic disorders of biological oxidation enzymes 26 2.71e-02 0.250000 1.84e-01
Regulation of FOXO transcriptional activity by acetylation 10 1.72e-01 0.249000 4.74e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.35e-01 0.249000 4.26e-01
Degradation of beta-catenin by the destruction complex 72 2.58e-04 0.249000 1.13e-02
Activated NTRK3 signals through RAS 7 2.55e-01 0.248000 5.73e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.74e-01 0.248000 4.75e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 7.37e-03 0.248000 8.48e-02
p53-Independent DNA Damage Response 39 7.37e-03 0.248000 8.48e-02
p53-Independent G1/S DNA damage checkpoint 39 7.37e-03 0.248000 8.48e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 2.56e-01 0.248000 5.73e-01
Activation of C3 and C5 7 2.58e-01 -0.247000 5.77e-01
Glutathione synthesis and recycling 10 1.77e-01 -0.247000 4.82e-01
Mismatch Repair 15 9.82e-02 -0.247000 3.70e-01
EPHA-mediated growth cone collapse 21 5.04e-02 0.247000 2.58e-01
Regulation of MECP2 expression and activity 29 2.16e-02 -0.246000 1.65e-01
Diseases of hemostasis 15 9.92e-02 0.246000 3.72e-01
Signaling by RNF43 mutants 7 2.61e-01 0.245000 5.81e-01
PI-3K cascade:FGFR1 13 1.26e-01 0.245000 4.15e-01
Phase 2 - plateau phase 11 1.59e-01 -0.245000 4.61e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 3.48e-02 0.244000 2.12e-01
Removal of the Flap Intermediate from the C-strand 17 8.20e-02 -0.244000 3.33e-01
RAS processing 23 4.38e-02 0.243000 2.42e-01
Proteasome assembly 50 2.98e-03 0.243000 5.29e-02
NIK–>noncanonical NF-kB signaling 46 4.48e-03 0.242000 6.53e-02
Activation of the AP-1 family of transcription factors 10 1.87e-01 0.241000 5.00e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 9.58e-02 0.241000 3.65e-01
Activation of BAD and translocation to mitochondria 15 1.07e-01 0.240000 3.84e-01
Alpha-protein kinase 1 signaling pathway 11 1.68e-01 0.240000 4.70e-01
G beta:gamma signalling through BTK 15 1.08e-01 0.240000 3.84e-01
Prevention of phagosomal-lysosomal fusion 9 2.14e-01 0.239000 5.29e-01
G alpha (z) signalling events 36 1.30e-02 0.239000 1.19e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.09e-01 0.239000 3.84e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 1.09e-01 0.239000 3.84e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 1.09e-01 0.239000 3.84e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 1.09e-01 0.239000 3.84e-01
Signaling by CTNNB1 phospho-site mutants 15 1.09e-01 0.239000 3.84e-01
Signaling by GSK3beta mutants 15 1.09e-01 0.239000 3.84e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 4.21e-03 0.239000 6.38e-02
DNA methylation 18 7.96e-02 -0.239000 3.31e-01
DAP12 signaling 28 2.89e-02 0.239000 1.91e-01
RHO GTPases Activate WASPs and WAVEs 35 1.48e-02 0.238000 1.31e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.38e-01 0.238000 4.29e-01
Cellular response to hypoxia 59 1.60e-03 0.237000 3.48e-02
SUMOylation of DNA replication proteins 46 5.41e-03 -0.237000 7.15e-02
Telomere C-strand (Lagging Strand) Synthesis 34 1.68e-02 -0.237000 1.44e-01
G0 and Early G1 27 3.33e-02 -0.237000 2.07e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 1.96e-01 -0.236000 5.10e-01
Regulation of CDH11 gene transcription 5 3.61e-01 -0.236000 6.56e-01
Killing mechanisms 9 2.21e-01 -0.236000 5.37e-01
WNT5:FZD7-mediated leishmania damping 9 2.21e-01 -0.236000 5.37e-01
Miro GTPase Cycle 8 2.49e-01 0.235000 5.65e-01
PRC2 methylates histones and DNA 27 3.43e-02 -0.235000 2.10e-01
Reelin signalling pathway 5 3.63e-01 0.235000 6.57e-01
Metabolism of polyamines 46 6.00e-03 0.234000 7.71e-02
Formation of apoptosome 11 1.80e-01 0.234000 4.82e-01
Regulation of the apoptosome activity 11 1.80e-01 0.234000 4.82e-01
SUMOylation of DNA methylation proteins 16 1.07e-01 -0.233000 3.84e-01
IRAK1 recruits IKK complex 14 1.32e-01 0.233000 4.24e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 1.32e-01 0.233000 4.24e-01
EGFR downregulation 27 3.70e-02 0.232000 2.20e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 8.86e-02 -0.232000 3.46e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 1.64e-01 0.232000 4.65e-01
Signaling by NOTCH4 70 7.95e-04 0.232000 2.29e-02
Purine ribonucleoside monophosphate biosynthesis 9 2.28e-01 -0.232000 5.38e-01
rRNA modification in the mitochondrion 8 2.56e-01 -0.232000 5.73e-01
Signaling by FGFR3 32 2.33e-02 0.232000 1.71e-01
Resolution of D-Loop Structures 35 1.78e-02 -0.231000 1.48e-01
Incretin synthesis, secretion, and inactivation 14 1.34e-01 0.231000 4.24e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.34e-01 0.231000 4.24e-01
GP1b-IX-V activation signalling 12 1.66e-01 0.231000 4.67e-01
FGFR2b ligand binding and activation 6 3.27e-01 -0.231000 6.41e-01
Other interleukin signaling 19 8.16e-02 -0.231000 3.33e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.99e-02 -0.231000 1.56e-01
Polo-like kinase mediated events 16 1.10e-01 -0.231000 3.85e-01
DAP12 interactions 39 1.27e-02 0.231000 1.18e-01
RUNX3 regulates CDKN1A transcription 7 2.92e-01 -0.230000 6.16e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 3.75e-01 -0.229000 6.72e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.74e-02 0.229000 1.47e-01
Prostanoid ligand receptors 8 2.62e-01 -0.229000 5.82e-01
Fertilization 12 1.70e-01 -0.229000 4.72e-01
Signaling by FGFR3 in disease 14 1.39e-01 0.228000 4.30e-01
Diseases associated with surfactant metabolism 6 3.34e-01 0.228000 6.42e-01
Vpr-mediated nuclear import of PICs 34 2.15e-02 -0.228000 1.65e-01
Nuclear events mediated by NFE2L2 82 3.81e-04 0.227000 1.53e-02
Interferon alpha/beta signaling 64 1.73e-03 0.226000 3.64e-02
Autodegradation of Cdh1 by Cdh1:APC/C 54 4.00e-03 0.226000 6.29e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.58e-01 0.226000 4.61e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 1.18e-01 0.226000 3.98e-01
Serotonin Neurotransmitter Release Cycle 15 1.31e-01 -0.225000 4.24e-01
Selective autophagy 77 6.42e-04 0.225000 2.03e-02
Interleukin-35 Signalling 12 1.78e-01 0.225000 4.82e-01
Signaling by FGFR4 32 2.80e-02 0.224000 1.87e-01
Regulation of TLR by endogenous ligand 15 1.32e-01 -0.224000 4.24e-01
Signaling by WNT in cancer 30 3.35e-02 0.224000 2.08e-01
The phototransduction cascade 26 4.82e-02 0.224000 2.54e-01
NFE2L2 regulating tumorigenic genes 11 1.99e-01 0.224000 5.13e-01
VEGF binds to VEGFR leading to receptor dimerization 5 3.87e-01 -0.223000 6.78e-01
VEGF ligand-receptor interactions 5 3.87e-01 -0.223000 6.78e-01
Activation of RAC1 downstream of NMDARs 7 3.07e-01 0.223000 6.23e-01
PCP/CE pathway 75 8.45e-04 0.223000 2.33e-02
Keratinization 37 1.93e-02 0.222000 1.54e-01
Platelet sensitization by LDL 16 1.24e-01 0.222000 4.12e-01
Class I peroxisomal membrane protein import 20 8.57e-02 -0.222000 3.41e-01
Pregnenolone biosynthesis 10 2.24e-01 -0.222000 5.38e-01
G2 Phase 5 3.90e-01 0.222000 6.79e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.53e-01 -0.221000 4.51e-01
SHC-mediated cascade:FGFR3 10 2.27e-01 0.221000 5.38e-01
Interleukin-12 signaling 44 1.13e-02 0.221000 1.10e-01
Interactions of Vpr with host cellular proteins 37 2.03e-02 -0.220000 1.58e-01
DARPP-32 events 22 7.38e-02 0.220000 3.21e-01
Regulation of RUNX2 expression and activity 54 5.18e-03 0.220000 6.93e-02
Transferrin endocytosis and recycling 26 5.24e-02 0.220000 2.59e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.74e-02 0.220000 2.22e-01
Intrinsic Pathway of Fibrin Clot Formation 15 1.42e-01 0.219000 4.33e-01
Growth hormone receptor signaling 21 8.27e-02 0.219000 3.34e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 7.58e-02 -0.219000 3.22e-01
Formation of Fibrin Clot (Clotting Cascade) 26 5.38e-02 0.219000 2.64e-01
VLDLR internalisation and degradation 16 1.31e-01 0.218000 4.24e-01
Activation of ATR in response to replication stress 37 2.19e-02 -0.218000 1.65e-01
MET promotes cell motility 33 3.06e-02 0.218000 1.98e-01
Histidine catabolism 7 3.20e-01 -0.217000 6.35e-01
Regulation of localization of FOXO transcription factors 11 2.12e-01 0.217000 5.27e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 3.34e-03 -0.217000 5.58e-02
Cardiogenesis 16 1.33e-01 -0.217000 4.24e-01
CDH11 homotypic and heterotypic interactions 6 3.59e-01 -0.216000 6.56e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.02e-02 -0.216000 2.29e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 3.22e-01 -0.216000 6.36e-01
ABC-family proteins mediated transport 81 7.75e-04 0.216000 2.29e-02
Sphingolipid de novo biosynthesis 34 2.94e-02 0.216000 1.93e-01
Na+/Cl- dependent neurotransmitter transporters 8 2.91e-01 0.216000 6.15e-01
Inactivation of CDC42 and RAC1 7 3.23e-01 0.216000 6.37e-01
Formation of the cornified envelope 36 2.52e-02 0.215000 1.79e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 3.24e-01 0.215000 6.38e-01
Somitogenesis 41 1.73e-02 0.215000 1.47e-01
p130Cas linkage to MAPK signaling for integrins 11 2.18e-01 0.214000 5.35e-01
Scavenging by Class F Receptors 5 4.07e-01 0.214000 6.92e-01
PKMTs methylate histone lysines 44 1.41e-02 -0.214000 1.26e-01
NFE2L2 regulating MDR associated enzymes 8 2.96e-01 0.214000 6.18e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.66e-02 -0.214000 1.82e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 3.66e-03 0.213000 6.00e-02
APC/C:Cdc20 mediated degradation of Securin 55 6.23e-03 0.213000 7.87e-02
Peptide ligand-binding receptors 101 2.14e-04 0.213000 1.03e-02
SUMOylation of transcription factors 16 1.41e-01 -0.213000 4.33e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.30e-01 -0.212000 4.22e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.30e-01 -0.212000 4.22e-01
RUNX3 regulates NOTCH signaling 14 1.69e-01 0.212000 4.72e-01
Induction of Cell-Cell Fusion 8 2.99e-01 -0.212000 6.18e-01
Signalling to ERKs 32 3.87e-02 0.211000 2.26e-01
Purine catabolism 16 1.44e-01 0.211000 4.35e-01
Budding and maturation of HIV virion 26 6.27e-02 0.211000 2.96e-01
Antigen processing-Cross presentation 89 5.85e-04 0.211000 1.97e-02
APC truncation mutants have impaired AXIN binding 14 1.73e-01 0.210000 4.74e-01
AXIN missense mutants destabilize the destruction complex 14 1.73e-01 0.210000 4.74e-01
Signaling by AMER1 mutants 14 1.73e-01 0.210000 4.74e-01
Signaling by APC mutants 14 1.73e-01 0.210000 4.74e-01
Signaling by AXIN mutants 14 1.73e-01 0.210000 4.74e-01
Truncations of AMER1 destabilize the destruction complex 14 1.73e-01 0.210000 4.74e-01
Fatty acids 6 3.74e-01 0.210000 6.71e-01
RHOH GTPase cycle 34 3.50e-02 0.209000 2.12e-01
Methylation 13 1.96e-01 0.207000 5.10e-01
Mitochondrial tRNA aminoacylation 21 1.01e-01 -0.207000 3.75e-01
DNA Damage Reversal 8 3.11e-01 -0.207000 6.27e-01
Suppression of apoptosis 7 3.45e-01 0.206000 6.46e-01
Alpha-oxidation of phytanate 6 3.82e-01 -0.206000 6.75e-01
Negative regulation of FGFR2 signaling 24 8.12e-02 0.206000 3.33e-01
Integrin signaling 22 9.51e-02 0.206000 3.64e-01
NRIF signals cell death from the nucleus 15 1.69e-01 0.205000 4.71e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 1.23e-03 -0.205000 2.89e-02
CYP2E1 reactions 6 3.85e-01 -0.205000 6.77e-01
Sema4D mediated inhibition of cell attachment and migration 7 3.48e-01 0.205000 6.48e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 5.22e-02 0.205000 2.59e-01
Cytochrome c-mediated apoptotic response 13 2.02e-01 0.204000 5.14e-01
Formation of paraxial mesoderm 52 1.09e-02 0.204000 1.07e-01
RHO GTPases activate PAKs 20 1.15e-01 0.204000 3.93e-01
Specification of primordial germ cells 6 3.91e-01 0.202000 6.79e-01
CREB phosphorylation 7 3.55e-01 0.202000 6.52e-01
KEAP1-NFE2L2 pathway 107 3.06e-04 0.202000 1.30e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.50e-01 -0.201000 4.47e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 8.14e-02 -0.201000 3.33e-01
Interleukin-12 family signaling 53 1.15e-02 0.201000 1.11e-01
Noncanonical activation of NOTCH3 8 3.26e-01 0.201000 6.39e-01
Neurexins and neuroligins 40 2.85e-02 -0.200000 1.89e-01
Displacement of DNA glycosylase by APEX1 9 2.99e-01 -0.200000 6.18e-01
Long-term potentiation 18 1.42e-01 -0.200000 4.33e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 7.24e-02 0.200000 3.18e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 7.00e-03 0.200000 8.35e-02
Pyrimidine catabolism 9 3.00e-01 0.200000 6.19e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 7.53e-03 0.199000 8.61e-02
Regulation of TP53 Activity through Association with Co-factors 13 2.15e-01 -0.199000 5.29e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 4.00e-01 -0.198000 6.85e-01
Transcriptional regulation by RUNX3 81 2.05e-03 0.198000 4.04e-02
Proton-coupled monocarboxylate transport 6 4.03e-01 0.197000 6.88e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 2.91e-02 0.197000 1.92e-01
Signal amplification 28 7.15e-02 0.197000 3.17e-01
Late endosomal microautophagy 30 6.30e-02 0.196000 2.96e-01
RHOT2 GTPase cycle 7 3.70e-01 0.196000 6.66e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.63e-01 -0.195000 4.65e-01
Interleukin-1 processing 8 3.39e-01 -0.195000 6.43e-01
IKK complex recruitment mediated by RIP1 23 1.05e-01 0.195000 3.83e-01
PI-3K cascade:FGFR4 11 2.63e-01 0.195000 5.83e-01
Cleavage of the damaged purine 22 1.14e-01 -0.195000 3.93e-01
Depurination 22 1.14e-01 -0.195000 3.93e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 1.14e-01 -0.195000 3.93e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 1.53e-01 0.194000 4.51e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 1.53e-01 0.194000 4.51e-01
Hedgehog ‘on’ state 65 6.94e-03 0.194000 8.34e-02
Acyl chain remodelling of PS 14 2.10e-01 0.194000 5.23e-01
Calcitonin-like ligand receptors 5 4.54e-01 0.194000 7.38e-01
Glutathione conjugation 28 7.67e-02 -0.193000 3.24e-01
NrCAM interactions 6 4.12e-01 -0.193000 6.95e-01
Methionine salvage pathway 6 4.13e-01 -0.193000 6.95e-01
Telomere C-strand synthesis initiation 13 2.29e-01 -0.193000 5.38e-01
Phase 3 - rapid repolarisation 6 4.15e-01 -0.192000 6.98e-01
Processive synthesis on the C-strand of the telomere 19 1.48e-01 -0.192000 4.42e-01
Inwardly rectifying K+ channels 24 1.05e-01 0.191000 3.82e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 8.64e-03 0.191000 9.37e-02
Regulation of CDH11 Expression and Function 23 1.12e-01 -0.191000 3.91e-01
MAPK1 (ERK2) activation 9 3.21e-01 0.191000 6.36e-01
NF-kB is activated and signals survival 12 2.52e-01 0.191000 5.68e-01
Netrin-1 signaling 35 5.20e-02 0.190000 2.59e-01
DNA Damage/Telomere Stress Induced Senescence 42 3.38e-02 -0.189000 2.09e-01
TGFBR3 PTM regulation 10 3.01e-01 0.189000 6.19e-01
Kidney development 17 1.78e-01 0.189000 4.82e-01
Golgi Associated Vesicle Biogenesis 55 1.56e-02 0.189000 1.36e-01
SCF(Skp2)-mediated degradation of p27/p21 50 2.12e-02 0.188000 1.65e-01
Viral Messenger RNA Synthesis 44 3.08e-02 -0.188000 1.98e-01
SUMOylation of SUMOylation proteins 35 5.41e-02 -0.188000 2.65e-01
Signaling by RAF1 mutants 37 4.79e-02 0.188000 2.54e-01
Interleukin-1 signaling 99 1.24e-03 0.188000 2.89e-02
Termination of O-glycan biosynthesis 16 1.95e-01 -0.187000 5.09e-01
SHC-related events triggered by IGF1R 8 3.60e-01 0.187000 6.56e-01
TRAF3-dependent IRF activation pathway 13 2.44e-01 -0.187000 5.59e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 2.63e-01 0.187000 5.83e-01
HS-GAG degradation 19 1.60e-01 -0.186000 4.61e-01
mRNA 3’-end processing 57 1.52e-02 0.186000 1.33e-01
SHC-mediated cascade:FGFR1 13 2.46e-01 0.186000 5.61e-01
CDK-mediated phosphorylation and removal of Cdc6 60 1.30e-02 0.185000 1.19e-01
Norepinephrine Neurotransmitter Release Cycle 14 2.31e-01 -0.185000 5.41e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 9.64e-02 -0.185000 3.67e-01
G-protein activation 19 1.64e-01 0.184000 4.65e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 3.13e-01 -0.184000 6.28e-01
Activation of RAS in B cells 5 4.77e-01 0.184000 7.60e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 7.24e-02 -0.184000 3.18e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 7.24e-02 -0.184000 3.18e-01
BBSome-mediated cargo-targeting to cilium 22 1.37e-01 -0.183000 4.29e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 8.85e-02 0.183000 3.46e-01
Homology Directed Repair 110 9.34e-04 -0.183000 2.44e-02
Dermatan sulfate biosynthesis 6 4.40e-01 0.182000 7.25e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.96e-01 0.182000 6.18e-01
Diseases of programmed cell death 58 1.66e-02 -0.182000 1.43e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 3.19e-01 0.182000 6.35e-01
E2F-enabled inhibition of pre-replication complex formation 9 3.45e-01 -0.182000 6.46e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 7.55e-02 -0.182000 3.22e-01
Triglyceride biosynthesis 10 3.20e-01 0.182000 6.36e-01
Regulation of Expression and Function of Type II Classical Cadherins 25 1.16e-01 -0.181000 3.97e-01
Regulation of Homotypic Cell-Cell Adhesion 25 1.16e-01 -0.181000 3.97e-01
Non-integrin membrane-ECM interactions 51 2.53e-02 0.181000 1.79e-01
MAPK6/MAPK4 signaling 69 9.45e-03 0.181000 9.82e-02
Nicotinamide salvaging 15 2.26e-01 0.181000 5.38e-01
IkBA variant leads to EDA-ID 7 4.08e-01 0.180000 6.92e-01
Downregulation of TGF-beta receptor signaling 26 1.12e-01 0.180000 3.90e-01
Signaling by EGFR 48 3.07e-02 0.180000 1.98e-01
Platelet activation, signaling and aggregation 223 3.55e-06 0.180000 4.03e-04
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 1.99e-01 -0.180000 5.13e-01
GAB1 signalosome 15 2.28e-01 0.180000 5.38e-01
Signaling by high-kinase activity BRAF mutants 33 7.45e-02 0.179000 3.21e-01
CLEC7A (Dectin-1) signaling 86 4.05e-03 0.179000 6.30e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 2.46e-01 0.179000 5.61e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 8.05e-02 -0.179000 3.32e-01
Metal ion SLC transporters 19 1.78e-01 0.178000 4.82e-01
Regulation of PTEN gene transcription 59 1.78e-02 -0.178000 1.48e-01
Signaling by NODAL 15 2.32e-01 0.178000 5.43e-01
HDR through Homologous Recombination (HRR) 68 1.12e-02 -0.178000 1.09e-01
HDACs deacetylate histones 45 3.90e-02 -0.178000 2.27e-01
Transcriptional Regulation by E2F6 34 7.28e-02 -0.178000 3.18e-01
MAP kinase activation 63 1.47e-02 0.178000 1.31e-01
Adherens junctions interactions 41 4.91e-02 -0.178000 2.55e-01
Syndecan interactions 26 1.18e-01 0.177000 3.98e-01
p53-Dependent G1 DNA Damage Response 52 2.71e-02 0.177000 1.84e-01
p53-Dependent G1/S DNA damage checkpoint 52 2.71e-02 0.177000 1.84e-01
Recycling pathway of L1 40 5.25e-02 0.177000 2.59e-01
Activated NTRK2 signals through RAS 6 4.53e-01 0.177000 7.38e-01
Impaired BRCA2 binding to PALB2 24 1.34e-01 -0.177000 4.24e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 5.07e-02 0.176000 2.58e-01
Signaling by RAS mutants 41 5.07e-02 0.176000 2.58e-01
Signaling by moderate kinase activity BRAF mutants 41 5.07e-02 0.176000 2.58e-01
Signaling downstream of RAS mutants 41 5.07e-02 0.176000 2.58e-01
Platelet degranulation 106 1.71e-03 0.176000 3.64e-02
HDMs demethylate histones 22 1.52e-01 -0.176000 4.51e-01
RAF activation 33 7.99e-02 0.176000 3.31e-01
Downstream signaling of activated FGFR3 17 2.09e-01 0.176000 5.21e-01
Nef and signal transduction 8 3.88e-01 0.176000 6.78e-01
MAP2K and MAPK activation 36 6.76e-02 0.176000 3.08e-01
Uptake and function of anthrax toxins 11 3.12e-01 0.176000 6.28e-01
FRS-mediated FGFR3 signaling 12 2.94e-01 0.175000 6.17e-01
Endosomal/Vacuolar pathway 12 2.94e-01 0.175000 6.17e-01
Regulation of signaling by CBL 22 1.55e-01 0.175000 4.55e-01
Translation of Structural Proteins 9694635 56 2.37e-02 0.175000 1.72e-01
rRNA processing in the mitochondrion 24 1.39e-01 0.175000 4.29e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.60e-02 0.174000 1.39e-01
Interleukin-1 family signaling 127 7.04e-04 0.174000 2.16e-02
Export of Viral Ribonucleoproteins from Nucleus 33 8.53e-02 -0.173000 3.41e-01
Signaling by CSF3 (G-CSF) 29 1.08e-01 0.172000 3.84e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.62e-01 0.172000 4.64e-01
Defective GALNT12 causes CRCS1 9 3.72e-01 -0.172000 6.68e-01
Laminin interactions 26 1.31e-01 0.171000 4.24e-01
Signaling by LTK in cancer 7 4.34e-01 0.171000 7.18e-01
Glycogen breakdown (glycogenolysis) 12 3.08e-01 0.170000 6.25e-01
L1CAM interactions 100 3.33e-03 0.170000 5.58e-02
Presynaptic depolarization and calcium channel opening 8 4.06e-01 -0.169000 6.91e-01
Release of apoptotic factors from the mitochondria 6 4.73e-01 -0.169000 7.59e-01
Defective factor IX causes hemophilia B 6 4.74e-01 0.169000 7.59e-01
Phospholipase C-mediated cascade; FGFR3 5 5.14e-01 0.169000 7.84e-01
Signaling by Hippo 18 2.16e-01 0.168000 5.32e-01
Calnexin/calreticulin cycle 26 1.37e-01 0.168000 4.29e-01
Signaling by ERBB2 ECD mutants 15 2.60e-01 0.168000 5.79e-01
Response to elevated platelet cytosolic Ca2+ 110 2.34e-03 0.168000 4.39e-02
Activation of G protein gated Potassium channels 20 1.94e-01 0.168000 5.07e-01
G protein gated Potassium channels 20 1.94e-01 0.168000 5.07e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 1.94e-01 0.168000 5.07e-01
Synthesis of pyrophosphates in the cytosol 8 4.11e-01 -0.168000 6.95e-01
Interleukin-27 signaling 11 3.36e-01 0.167000 6.42e-01
RND2 GTPase cycle 37 7.82e-02 -0.167000 3.28e-01
Signaling by Insulin receptor 63 2.18e-02 0.167000 1.65e-01
DNA Double-Strand Break Repair 137 7.63e-04 -0.167000 2.29e-02
Synthesis of 5-eicosatetraenoic acids 7 4.49e-01 0.165000 7.35e-01
Nuclear events stimulated by ALK signaling in cancer 33 1.01e-01 -0.165000 3.75e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 1.12e-01 0.165000 3.91e-01
GRB2 events in EGFR signaling 11 3.44e-01 0.165000 6.46e-01
Elastic fibre formation 33 1.02e-01 -0.165000 3.77e-01
Amino acid transport across the plasma membrane 26 1.46e-01 0.165000 4.39e-01
Anti-inflammatory response favouring Leishmania parasite infection 132 1.12e-03 -0.164000 2.78e-02
Leishmania parasite growth and survival 132 1.12e-03 -0.164000 2.78e-02
Regulation of APC/C activators between G1/S and early anaphase 68 1.92e-02 0.164000 1.54e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 1.09e-04 -0.164000 6.22e-03
Erythropoietin activates RAS 13 3.07e-01 0.164000 6.23e-01
Signaling by FGFR1 42 6.70e-02 0.163000 3.07e-01
Gamma-carboxylation of protein precursors 6 4.89e-01 -0.163000 7.68e-01
mRNA Splicing - Major Pathway 203 6.13e-05 0.163000 4.75e-03
Organic cation transport 8 4.25e-01 0.163000 7.10e-01
Organic cation/anion/zwitterion transport 8 4.25e-01 0.163000 7.10e-01
Signaling by PDGFRA extracellular domain mutants 12 3.30e-01 0.162000 6.42e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.30e-01 0.162000 6.42e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.60e-01 -0.162000 4.61e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.60e-01 -0.162000 4.61e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.60e-01 -0.162000 4.61e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.60e-01 -0.162000 4.61e-01
SUMOylation of chromatin organization proteins 57 3.46e-02 -0.162000 2.11e-01
Potential therapeutics for SARS 149 6.79e-04 -0.161000 2.12e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 3.55e-01 -0.161000 6.52e-01
Hedgehog ‘off’ state 91 7.98e-03 0.161000 8.91e-02
Gap junction trafficking 28 1.41e-01 0.161000 4.33e-01
Regulation of actin dynamics for phagocytic cup formation 123 2.11e-03 -0.160000 4.12e-02
Transport of bile salts and organic acids, metal ions and amine compounds 52 4.57e-02 0.160000 2.47e-01
Regulation of endogenous retroelements 92 7.97e-03 -0.160000 8.91e-02
Rev-mediated nuclear export of HIV RNA 35 1.02e-01 -0.160000 3.78e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 5.37e-01 0.160000 7.96e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 5.37e-01 0.160000 7.96e-01
Assembly Of The HIV Virion 15 2.85e-01 0.159000 6.06e-01
COPI-mediated anterograde transport 92 8.25e-03 0.159000 9.11e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 5.07e-03 -0.159000 6.87e-02
GDP-fucose biosynthesis 6 5.01e-01 -0.159000 7.74e-01
Transcriptional Regulation by VENTX 39 8.65e-02 -0.159000 3.42e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 2.44e-01 -0.159000 5.59e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.63e-01 0.158000 6.57e-01
Interleukin-17 signaling 68 2.39e-02 0.158000 1.72e-01
Paracetamol ADME 19 2.34e-01 -0.158000 5.45e-01
Sodium/Calcium exchangers 9 4.13e-01 0.158000 6.95e-01
Thromboxane signalling through TP receptor 20 2.22e-01 0.158000 5.38e-01
Heme biosynthesis 13 3.25e-01 -0.158000 6.38e-01
Downstream signaling of activated FGFR1 22 2.04e-01 0.157000 5.16e-01
GABA receptor activation 38 9.57e-02 0.156000 3.65e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.53e-01 0.156000 4.51e-01
Nef Mediated CD8 Down-regulation 7 4.75e-01 0.156000 7.59e-01
mRNA Splicing 211 9.36e-05 0.156000 5.78e-03
InlB-mediated entry of Listeria monocytogenes into host cell 12 3.51e-01 0.156000 6.49e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 6.85e-02 -0.155000 3.08e-01
Nuclear import of Rev protein 34 1.18e-01 -0.155000 3.98e-01
Signaling by MET 68 2.73e-02 0.155000 1.84e-01
FRS-mediated FGFR1 signaling 15 3.02e-01 0.154000 6.19e-01
SUMO is proteolytically processed 6 5.14e-01 -0.154000 7.84e-01
MET activates RAS signaling 10 4.00e-01 0.154000 6.85e-01
Signaling by EGFR in Cancer 23 2.02e-01 0.154000 5.14e-01
Heme degradation 11 3.81e-01 0.153000 6.73e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 3.81e-01 0.153000 6.73e-01
Cohesin Loading onto Chromatin 10 4.03e-01 0.153000 6.88e-01
Signaling by PDGFR in disease 19 2.51e-01 0.152000 5.68e-01
Acyl chain remodelling of PG 11 3.84e-01 0.152000 6.77e-01
Sialic acid metabolism 28 1.67e-01 -0.151000 4.69e-01
Digestion and absorption 7 4.92e-01 0.150000 7.69e-01
RIPK1-mediated regulated necrosis 31 1.49e-01 0.150000 4.44e-01
Regulation of necroptotic cell death 31 1.49e-01 0.150000 4.44e-01
p75NTR signals via NF-kB 15 3.16e-01 0.149000 6.33e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.26e-01 0.149000 4.15e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.33e-01 0.149000 6.42e-01
Wax and plasmalogen biosynthesis 5 5.63e-01 0.149000 8.13e-01
Mucopolysaccharidoses 11 3.92e-01 -0.149000 6.80e-01
Activation of SMO 13 3.52e-01 -0.149000 6.51e-01
Sulfur amino acid metabolism 23 2.16e-01 -0.149000 5.32e-01
Sphingolipid catabolism 11 3.94e-01 0.149000 6.81e-01
Transcriptional regulation by small RNAs 61 4.49e-02 -0.148000 2.43e-01
Beta-oxidation of pristanoyl-CoA 9 4.41e-01 -0.148000 7.27e-01
Fanconi Anemia Pathway 36 1.24e-01 -0.148000 4.12e-01
Calcineurin activates NFAT 9 4.42e-01 0.148000 7.27e-01
ADP signalling through P2Y purinoceptor 1 21 2.41e-01 0.148000 5.56e-01
Signaling by Hedgehog 120 5.20e-03 0.148000 6.93e-02
FGFR1b ligand binding and activation 5 5.68e-01 0.148000 8.15e-01
EPH-Ephrin signaling 81 2.19e-02 0.147000 1.65e-01
Homologous DNA Pairing and Strand Exchange 43 9.48e-02 -0.147000 3.64e-01
Neurotransmitter clearance 6 5.33e-01 0.147000 7.95e-01
Constitutive Signaling by EGFRvIII 14 3.40e-01 0.147000 6.43e-01
Signaling by EGFRvIII in Cancer 14 3.40e-01 0.147000 6.43e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.27e-01 0.147000 4.18e-01
Signaling by TGFBR3 39 1.13e-01 -0.147000 3.91e-01
Activation of gene expression by SREBF (SREBP) 42 1.01e-01 -0.146000 3.75e-01
Zinc transporters 12 3.80e-01 0.146000 6.73e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 5.71e-01 -0.146000 8.16e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 7.19e-02 0.146000 3.18e-01
Diseases associated with O-glycosylation of proteins 50 7.51e-02 -0.145000 3.21e-01
PKR-mediated signaling 67 3.97e-02 0.145000 2.28e-01
Diseases of DNA repair 51 7.29e-02 -0.145000 3.18e-01
Amyloid fiber formation 52 7.03e-02 0.145000 3.14e-01
DNA Double Strand Break Response 47 8.53e-02 -0.145000 3.41e-01
IRE1alpha activates chaperones 46 8.92e-02 0.145000 3.46e-01
RNA Polymerase II Transcription Termination 66 4.20e-02 0.145000 2.36e-01
G1/S DNA Damage Checkpoints 54 6.58e-02 0.145000 3.03e-01
Transcriptional regulation of pluripotent stem cells 21 2.52e-01 0.144000 5.68e-01
Smooth Muscle Contraction 34 1.46e-01 0.144000 4.37e-01
Defective RIPK1-mediated regulated necrosis 7 5.10e-01 -0.144000 7.81e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 3.01e-02 0.144000 1.96e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.91e-01 -0.143000 6.79e-01
FCGR3A-mediated phagocytosis 121 6.63e-03 -0.143000 8.10e-02
Leishmania phagocytosis 121 6.63e-03 -0.143000 8.10e-02
Parasite infection 121 6.63e-03 -0.143000 8.10e-02
Negative regulation of MAPK pathway 42 1.10e-01 0.143000 3.84e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.27e-01 0.143000 5.38e-01
Lysosphingolipid and LPA receptors 11 4.14e-01 -0.142000 6.97e-01
Peroxisomal lipid metabolism 27 2.01e-01 -0.142000 5.14e-01
Collagen biosynthesis and modifying enzymes 48 8.88e-02 -0.142000 3.46e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 5.16e-01 -0.142000 7.86e-01
Cytosolic sensors of pathogen-associated DNA 63 5.18e-02 0.142000 2.59e-01
Fibronectin matrix formation 6 5.49e-01 -0.141000 8.06e-01
Cytochrome P450 - arranged by substrate type 38 1.32e-01 0.141000 4.24e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 3.61e-01 -0.141000 6.56e-01
G2/M DNA replication checkpoint 5 5.86e-01 -0.141000 8.24e-01
SHC1 events in EGFR signaling 12 3.99e-01 0.141000 6.85e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.24e-01 -0.141000 4.12e-01
Macroautophagy 128 6.03e-03 0.141000 7.71e-02
Respiratory syncytial virus (RSV) attachment and entry 18 3.04e-01 0.140000 6.22e-01
Deadenylation of mRNA 22 2.56e-01 0.140000 5.73e-01
Interleukin-6 family signaling 20 2.79e-01 -0.140000 6.03e-01
DNA Repair 289 4.40e-05 -0.140000 3.70e-03
Maturation of spike protein 9683686 5 5.89e-01 -0.140000 8.25e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 5.95e-02 0.139000 2.85e-01
IL-6-type cytokine receptor ligand interactions 13 3.84e-01 -0.139000 6.77e-01
Cytosolic sulfonation of small molecules 18 3.07e-01 0.139000 6.23e-01
Reversal of alkylation damage by DNA dioxygenases 7 5.24e-01 -0.139000 7.92e-01
Protein ubiquitination 71 4.33e-02 0.139000 2.40e-01
DCC mediated attractive signaling 13 3.87e-01 0.139000 6.78e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 3.39e-01 -0.138000 6.43e-01
Autophagy 142 4.54e-03 0.138000 6.54e-02
Synaptic adhesion-like molecules 17 3.25e-01 -0.138000 6.38e-01
Metabolism of water-soluble vitamins and cofactors 115 1.06e-02 -0.138000 1.06e-01
Glycogen storage diseases 13 3.90e-01 0.138000 6.79e-01
Signaling by FGFR2 61 6.28e-02 0.138000 2.96e-01
Transport of the SLBP Dependant Mature mRNA 36 1.53e-01 -0.138000 4.51e-01
Base-Excision Repair, AP Site Formation 29 1.99e-01 -0.138000 5.13e-01
Formation of ATP by chemiosmotic coupling 20 2.87e-01 0.138000 6.08e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 5.29e-01 0.137000 7.94e-01
Phase I - Functionalization of compounds 70 4.72e-02 0.137000 2.51e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 1.55e-01 0.137000 4.53e-01
Vitamin D (calciferol) metabolism 11 4.32e-01 -0.137000 7.17e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 4.94e-02 0.137000 2.56e-01
Signaling by ALK 24 2.47e-01 -0.136000 5.62e-01
Cell surface interactions at the vascular wall 176 1.79e-03 -0.136000 3.72e-02
Iron uptake and transport 52 8.89e-02 0.136000 3.46e-01
Nephrin family interactions 20 2.91e-01 0.136000 6.15e-01
Synthesis of PIPs at the early endosome membrane 16 3.46e-01 -0.136000 6.47e-01
Condensation of Prophase Chromosomes 27 2.21e-01 -0.136000 5.37e-01
Signaling by LTK 10 4.57e-01 -0.136000 7.40e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 4.49e-03 -0.136000 6.53e-02
FGFR2 ligand binding and activation 9 4.81e-01 -0.136000 7.64e-01
RHO GTPases activate PKNs 46 1.13e-01 0.135000 3.91e-01
Vitamin B5 (pantothenate) metabolism 20 2.96e-01 -0.135000 6.18e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.03e-01 0.134000 5.15e-01
Transport of the SLBP independent Mature mRNA 35 1.69e-01 -0.134000 4.72e-01
Meiotic recombination 37 1.58e-01 -0.134000 4.61e-01
Axon guidance 459 8.65e-07 0.134000 1.19e-04
Amino acids regulate mTORC1 48 1.09e-01 0.134000 3.84e-01
APOBEC3G mediated resistance to HIV-1 infection 5 6.04e-01 -0.134000 8.33e-01
Role of ABL in ROBO-SLIT signaling 6 5.71e-01 0.134000 8.16e-01
G beta:gamma signalling through PI3Kgamma 22 2.78e-01 0.134000 6.01e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 1.66e-01 -0.133000 4.68e-01
Defective B4GALT7 causes EDS, progeroid type 11 4.44e-01 -0.133000 7.29e-01
Beta-catenin independent WNT signaling 126 9.90e-03 0.133000 1.00e-01
Metabolism of fat-soluble vitamins 28 2.24e-01 -0.133000 5.38e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 2.70e-01 -0.133000 5.91e-01
Unfolded Protein Response (UPR) 84 3.57e-02 0.133000 2.14e-01
Activation of Matrix Metalloproteinases 22 2.82e-01 -0.132000 6.03e-01
Regulation of beta-cell development 22 2.84e-01 0.132000 6.05e-01
Transport of RCbl within the body 8 5.18e-01 0.132000 7.88e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 1.07e-01 -0.132000 3.84e-01
APC/C-mediated degradation of cell cycle proteins 75 4.86e-02 0.132000 2.54e-01
Regulation of mitotic cell cycle 75 4.86e-02 0.132000 2.54e-01
Glutamate Neurotransmitter Release Cycle 20 3.09e-01 -0.131000 6.25e-01
Phospholipase C-mediated cascade: FGFR1 8 5.20e-01 0.131000 7.89e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.37e-01 -0.131000 4.29e-01
Regulation of RUNX1 Expression and Activity 18 3.36e-01 -0.131000 6.42e-01
Signaling by Retinoic Acid 29 2.22e-01 -0.131000 5.38e-01
Gastrulation 76 4.89e-02 0.131000 2.55e-01
trans-Golgi Network Vesicle Budding 69 6.08e-02 0.131000 2.89e-01
The NLRP3 inflammasome 16 3.68e-01 -0.130000 6.63e-01
Cation-coupled Chloride cotransporters 6 5.82e-01 -0.130000 8.21e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 5.00e-01 -0.130000 7.74e-01
ER Quality Control Compartment (ERQC) 21 3.04e-01 0.129000 6.22e-01
SUMOylation of ubiquitinylation proteins 39 1.62e-01 -0.129000 4.64e-01
Vitamin C (ascorbate) metabolism 8 5.29e-01 -0.129000 7.94e-01
Protein folding 83 4.30e-02 0.128000 2.40e-01
Chaperonin-mediated protein folding 77 5.14e-02 0.128000 2.59e-01
E2F mediated regulation of DNA replication 22 2.97e-01 -0.128000 6.18e-01
ROS and RNS production in phagocytes 30 2.24e-01 0.128000 5.38e-01
Amine ligand-binding receptors 10 4.84e-01 -0.128000 7.66e-01
tRNA processing in the nucleus 59 8.95e-02 -0.128000 3.46e-01
Interleukin-21 signaling 9 5.07e-01 -0.128000 7.78e-01
Interactions of Rev with host cellular proteins 37 1.79e-01 -0.128000 4.82e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 3.36e-01 -0.127000 6.42e-01
Triglyceride metabolism 26 2.61e-01 0.127000 5.81e-01
Neurofascin interactions 5 6.23e-01 0.127000 8.40e-01
Late SARS-CoV-2 Infection Events 64 8.03e-02 0.126000 3.31e-01
Early SARS-CoV-2 Infection Events 31 2.23e-01 0.126000 5.38e-01
Telomere Extension By Telomerase 23 2.94e-01 0.126000 6.17e-01
RNA Polymerase III Chain Elongation 18 3.54e-01 0.126000 6.52e-01
Aquaporin-mediated transport 38 1.79e-01 0.126000 4.82e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.55e-01 -0.126000 6.52e-01
Maternal to zygotic transition (MZT) 72 6.47e-02 0.126000 2.99e-01
MAPK3 (ERK1) activation 10 4.91e-01 0.126000 7.69e-01
Dual Incision in GG-NER 41 1.63e-01 -0.126000 4.65e-01
Cellular response to chemical stress 179 3.71e-03 0.126000 6.01e-02
Recycling of eIF2:GDP 8 5.38e-01 0.126000 7.97e-01
TRAF6 mediated NF-kB activation 23 2.97e-01 -0.126000 6.18e-01
rRNA modification in the nucleus and cytosol 59 9.67e-02 0.125000 3.67e-01
Signaling by NTRK2 (TRKB) 20 3.34e-01 0.125000 6.42e-01
Signaling by BMP 23 3.00e-01 -0.125000 6.19e-01
Metabolism of vitamins and cofactors 166 5.56e-03 -0.125000 7.31e-02
SHC-mediated cascade:FGFR4 11 4.74e-01 0.125000 7.59e-01
RAF/MAP kinase cascade 226 1.28e-03 0.124000 2.94e-02
Regulation of TP53 Activity through Methylation 19 3.48e-01 -0.124000 6.48e-01
Interleukin-7 signaling 21 3.24e-01 0.124000 6.38e-01
Extra-nuclear estrogen signaling 67 7.92e-02 0.124000 3.31e-01
Gap junction trafficking and regulation 30 2.41e-01 0.124000 5.55e-01
NADE modulates death signalling 5 6.32e-01 0.124000 8.40e-01
Transcriptional activation of mitochondrial biogenesis 52 1.23e-01 -0.123000 4.12e-01
Processing of Intronless Pre-mRNAs 20 3.39e-01 0.123000 6.43e-01
Assembly of the ORC complex at the origin of replication 23 3.06e-01 -0.123000 6.23e-01
Signal transduction by L1 20 3.41e-01 0.123000 6.43e-01
Pexophagy 10 5.01e-01 -0.123000 7.74e-01
Dopamine Neurotransmitter Release Cycle 20 3.41e-01 -0.123000 6.43e-01
Ethanol oxidation 8 5.47e-01 -0.123000 8.05e-01
Effects of PIP2 hydrolysis 24 2.98e-01 -0.123000 6.18e-01
Prostacyclin signalling through prostacyclin receptor 16 3.96e-01 0.123000 6.82e-01
C-type lectin receptors (CLRs) 118 2.17e-02 0.122000 1.65e-01
activated TAK1 mediates p38 MAPK activation 23 3.12e-01 0.122000 6.27e-01
Orc1 removal from chromatin 58 1.09e-01 0.122000 3.84e-01
Receptor Mediated Mitophagy 11 4.85e-01 0.122000 7.66e-01
Azathioprine ADME 21 3.35e-01 -0.122000 6.42e-01
Gain-of-function MRAS complexes activate RAF signaling 8 5.51e-01 0.122000 8.08e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 5.51e-01 0.122000 8.08e-01
Signaling by MRAS-complex mutants 8 5.51e-01 0.122000 8.08e-01
Metabolism of non-coding RNA 53 1.26e-01 -0.122000 4.15e-01
snRNP Assembly 53 1.26e-01 -0.122000 4.15e-01
Downstream TCR signaling 89 4.76e-02 0.121000 2.53e-01
Cobalamin (Cbl) metabolism 7 5.80e-01 -0.121000 8.21e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 6.40e-01 -0.121000 8.43e-01
RUNX2 regulates genes involved in cell migration 6 6.09e-01 -0.121000 8.35e-01
STAT3 nuclear events downstream of ALK signaling 11 4.89e-01 -0.121000 7.68e-01
eNOS activation 12 4.70e-01 0.120000 7.56e-01
RNA Polymerase III Transcription Termination 23 3.18e-01 0.120000 6.34e-01
RMTs methylate histone arginines 35 2.19e-01 -0.120000 5.35e-01
Retinoid metabolism and transport 25 2.99e-01 -0.120000 6.18e-01
Sema3A PAK dependent Axon repulsion 15 4.21e-01 0.120000 7.07e-01
Downstream signaling of activated FGFR4 18 3.79e-01 0.120000 6.73e-01
FLT3 signaling through SRC family kinases 6 6.11e-01 0.120000 8.36e-01
Endogenous sterols 18 3.79e-01 0.120000 6.73e-01
Signaling by PDGF 50 1.43e-01 0.120000 4.35e-01
HDR through Single Strand Annealing (SSA) 37 2.07e-01 -0.120000 5.19e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 2.34e-01 0.120000 5.46e-01
Cyclin E associated events during G1/S transition 73 7.73e-02 0.120000 3.26e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 1.44e-01 0.119000 4.35e-01
Programmed Cell Death 187 4.88e-03 0.119000 6.74e-02
Formation of the nephric duct 8 5.59e-01 0.119000 8.12e-01
Activated NTRK2 signals through FRS2 and FRS3 8 5.59e-01 0.119000 8.12e-01
Common Pathway of Fibrin Clot Formation 13 4.57e-01 0.119000 7.40e-01
Creatine metabolism 6 6.13e-01 -0.119000 8.36e-01
Nuclear Envelope Breakdown 53 1.34e-01 -0.119000 4.24e-01
Constitutive Signaling by Overexpressed ERBB2 11 4.95e-01 0.119000 7.71e-01
Glycosphingolipid catabolism 31 2.53e-01 -0.119000 5.70e-01
Keratan sulfate biosynthesis 20 3.59e-01 -0.118000 6.56e-01
Maturation of spike protein 9694548 36 2.19e-01 0.118000 5.35e-01
MAPK1/MAPK3 signaling 232 1.91e-03 0.118000 3.84e-02
Activation of the TFAP2 (AP-2) family of transcription factors 7 5.88e-01 -0.118000 8.25e-01
Attenuation phase 23 3.28e-01 0.118000 6.42e-01
PI3K events in ERBB2 signaling 11 4.99e-01 0.118000 7.73e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 4.99e-01 0.118000 7.73e-01
Pre-NOTCH Processing in Golgi 18 3.88e-01 -0.118000 6.78e-01
Cell recruitment (pro-inflammatory response) 25 3.11e-01 -0.117000 6.27e-01
Purinergic signaling in leishmaniasis infection 25 3.11e-01 -0.117000 6.27e-01
Gene Silencing by RNA 87 5.90e-02 -0.117000 2.83e-01
Costimulation by the CD28 family 74 8.17e-02 -0.117000 3.33e-01
Nonhomologous End-Joining (NHEJ) 40 2.00e-01 -0.117000 5.14e-01
Clathrin-mediated endocytosis 128 2.23e-02 0.117000 1.68e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 3.23e-01 0.117000 6.37e-01
EPHB-mediated forward signaling 40 2.02e-01 0.117000 5.14e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.97e-01 -0.116000 5.13e-01
Diseases of DNA Double-Strand Break Repair 41 1.97e-01 -0.116000 5.13e-01
Cristae formation 33 2.50e-01 0.116000 5.66e-01
Vitamin B2 (riboflavin) metabolism 6 6.25e-01 -0.115000 8.40e-01
Downregulation of ERBB4 signaling 8 5.73e-01 0.115000 8.17e-01
Nervous system development 478 1.60e-05 0.115000 1.55e-03
Ubiquinol biosynthesis 13 4.73e-01 -0.115000 7.59e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 3.63e-01 0.115000 6.57e-01
PERK regulates gene expression 30 2.77e-01 0.115000 6.00e-01
Interleukin-37 signaling 19 3.87e-01 0.115000 6.78e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 6.58e-01 -0.114000 8.52e-01
TICAM1-dependent activation of IRF3/IRF7 13 4.76e-01 0.114000 7.60e-01
SUMOylation 167 1.10e-02 -0.114000 1.08e-01
FLT3 signaling by CBL mutants 7 6.02e-01 0.114000 8.33e-01
Notch-HLH transcription pathway 28 2.98e-01 -0.114000 6.18e-01
Cytosolic tRNA aminoacylation 24 3.35e-01 0.114000 6.42e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.08e-03 0.114000 2.75e-02
Cell-cell junction organization 60 1.29e-01 -0.113000 4.21e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 2.41e-01 -0.113000 5.55e-01
Toll Like Receptor 3 (TLR3) Cascade 104 4.71e-02 0.113000 2.51e-01
Activation of GABAB receptors 31 2.78e-01 0.113000 6.00e-01
GABA B receptor activation 31 2.78e-01 0.113000 6.00e-01
Phospholipase C-mediated cascade; FGFR2 8 5.81e-01 -0.113000 8.21e-01
Regulation of HMOX1 expression and activity 5 6.64e-01 0.112000 8.54e-01
ERKs are inactivated 13 4.83e-01 0.112000 7.66e-01
SUMOylation of DNA damage response and repair proteins 77 8.94e-02 -0.112000 3.46e-01
FGFR1c ligand binding and activation 8 5.85e-01 0.112000 8.24e-01
SUMO E3 ligases SUMOylate target proteins 161 1.46e-02 -0.112000 1.30e-01
XBP1(S) activates chaperone genes 44 2.01e-01 0.111000 5.14e-01
Maturation of protein 3a 9683673 9 5.63e-01 -0.111000 8.13e-01
Maturation of protein 3a 9694719 9 5.63e-01 -0.111000 8.13e-01
Regulation of TP53 Expression and Degradation 36 2.48e-01 0.111000 5.64e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 2.08e-01 -0.111000 5.19e-01
G beta:gamma signalling through CDC42 17 4.28e-01 0.111000 7.13e-01
OAS antiviral response 8 5.88e-01 0.111000 8.25e-01
Trafficking and processing of endosomal TLR 13 4.90e-01 -0.111000 7.69e-01
SUMOylation of RNA binding proteins 47 1.90e-01 -0.111000 5.03e-01
Signaling by FGFR4 in disease 11 5.26e-01 0.110000 7.92e-01
Cell junction organization 82 8.41e-02 -0.110000 3.38e-01
Urea cycle 7 6.13e-01 0.110000 8.36e-01
Apoptotic cleavage of cell adhesion proteins 8 5.89e-01 0.110000 8.25e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 3.05e-01 0.110000 6.22e-01
Arachidonate metabolism 45 2.02e-01 0.110000 5.14e-01
MASTL Facilitates Mitotic Progression 10 5.47e-01 0.110000 8.05e-01
Sensory Perception 197 7.81e-03 0.110000 8.83e-02
Pre-NOTCH Transcription and Translation 47 1.93e-01 -0.110000 5.07e-01
FGFR2 alternative splicing 25 3.43e-01 0.110000 6.46e-01
Blood group systems biosynthesis 18 4.21e-01 0.110000 7.07e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 3.53e-01 -0.109000 6.52e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 3.53e-01 -0.109000 6.52e-01
Golgi-to-ER retrograde transport 123 3.65e-02 0.109000 2.18e-01
ERK/MAPK targets 22 3.78e-01 0.109000 6.73e-01
FGFR3 ligand binding and activation 5 6.74e-01 0.109000 8.60e-01
FGFR3c ligand binding and activation 5 6.74e-01 0.109000 8.60e-01
MAPK family signaling cascades 264 2.43e-03 0.108000 4.52e-02
Metabolism of cofactors 25 3.49e-01 -0.108000 6.48e-01
Protein-protein interactions at synapses 61 1.44e-01 -0.108000 4.35e-01
TCR signaling 110 5.00e-02 0.108000 2.58e-01
MET activates PTK2 signaling 23 3.70e-01 0.108000 6.67e-01
Apoptosis 158 1.94e-02 0.108000 1.54e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.28e-01 -0.107000 5.38e-01
Deactivation of the beta-catenin transactivating complex 36 2.66e-01 -0.107000 5.85e-01
Packaging Of Telomere Ends 18 4.33e-01 -0.107000 7.17e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 5.05e-01 0.107000 7.78e-01
Cleavage of the damaged pyrimidine 27 3.38e-01 -0.107000 6.42e-01
Depyrimidination 27 3.38e-01 -0.107000 6.42e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 3.38e-01 -0.107000 6.42e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.76e-01 -0.107000 6.73e-01
TRAF6 mediated IRF7 activation 15 4.75e-01 -0.107000 7.59e-01
Synthesis of Dolichyl-phosphate 6 6.52e-01 0.106000 8.48e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 3.88e-01 0.106000 6.78e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 4.92e-01 -0.106000 7.69e-01
MyD88-independent TLR4 cascade 108 5.69e-02 0.106000 2.75e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 5.69e-02 0.106000 2.75e-01
Adenylate cyclase activating pathway 8 6.04e-01 -0.106000 8.33e-01
Semaphorin interactions 56 1.71e-01 0.106000 4.73e-01
CD28 dependent PI3K/Akt signaling 22 3.91e-01 -0.106000 6.79e-01
Abacavir ADME 5 6.84e-01 0.105000 8.65e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 2.29e-01 0.105000 5.38e-01
Regulation of expression of SLITs and ROBOs 149 2.73e-02 0.105000 1.84e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.95e-01 0.105000 6.82e-01
Aspirin ADME 16 4.69e-01 0.105000 7.55e-01
Linoleic acid (LA) metabolism 7 6.32e-01 -0.104000 8.40e-01
Inhibition of Signaling by Overexpressed EGFR 6 6.58e-01 0.104000 8.52e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 6.58e-01 0.104000 8.52e-01
Intraflagellar transport 47 2.19e-01 -0.104000 5.35e-01
Ribosomal scanning and start codon recognition 58 1.73e-01 0.104000 4.74e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 5.92e-01 -0.103000 8.28e-01
PIWI-interacting RNA (piRNA) biogenesis 23 3.96e-01 -0.102000 6.82e-01
Lysine catabolism 11 5.59e-01 -0.102000 8.12e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 4.96e-01 0.102000 7.71e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 4.44e-01 0.102000 7.29e-01
PLC beta mediated events 40 2.67e-01 -0.101000 5.86e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.80e-01 -0.101000 6.03e-01
Extension of Telomeres 51 2.11e-01 -0.101000 5.26e-01
Interaction between L1 and Ankyrins 26 3.72e-01 0.101000 6.69e-01
PDH complex synthesizes acetyl-CoA from PYR 5 6.96e-01 0.101000 8.70e-01
RHOJ GTPase cycle 50 2.19e-01 0.101000 5.35e-01
Translation initiation complex formation 58 1.85e-01 0.101000 4.96e-01
Keratan sulfate/keratin metabolism 28 3.58e-01 -0.100000 6.56e-01
Antiviral mechanism by IFN-stimulated genes 140 4.04e-02 0.100000 2.29e-01
NS1 Mediated Effects on Host Pathways 40 2.73e-01 -0.100000 5.96e-01
Respiratory Syncytial Virus Infection Pathway 99 8.54e-02 0.100000 3.41e-01
Signaling by TGF-beta Receptor Complex 91 9.92e-02 0.100000 3.72e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 6.72e-01 0.099800 8.60e-01
TGFBR1 KD Mutants in Cancer 6 6.72e-01 0.099800 8.60e-01
Signaling by Erythropoietin 24 3.98e-01 0.099700 6.85e-01
Collagen formation 66 1.62e-01 -0.099600 4.64e-01
GRB2 events in ERBB2 signaling 11 5.67e-01 0.099600 8.15e-01
Nuclear Envelope (NE) Reassembly 68 1.56e-01 0.099600 4.55e-01
Bacterial Infection Pathways 66 1.62e-01 0.099500 4.64e-01
Initiation of Nuclear Envelope (NE) Reformation 19 4.55e-01 0.099000 7.39e-01
Apoptotic execution phase 46 2.46e-01 0.098800 5.61e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 4.81e-01 0.098700 7.64e-01
Cytoprotection by HMOX1 53 2.14e-01 0.098700 5.29e-01
Signaling by Interleukins 391 8.26e-04 0.098500 2.32e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 5.55e-01 -0.098300 8.10e-01
p75NTR recruits signalling complexes 12 5.56e-01 0.098300 8.10e-01
Other semaphorin interactions 16 4.96e-01 0.098200 7.71e-01
Cyclin A:Cdk2-associated events at S phase entry 75 1.42e-01 0.098000 4.33e-01
Signaling by WNT 241 8.90e-03 0.097800 9.50e-02
UCH proteinases 73 1.49e-01 0.097800 4.44e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 1.17e-01 0.097800 3.98e-01
Host Interactions of HIV factors 118 6.80e-02 0.097300 3.08e-01
FRS-mediated FGFR4 signaling 13 5.44e-01 0.097200 8.03e-01
ADORA2B mediated anti-inflammatory cytokines production 36 3.14e-01 0.097000 6.30e-01
PI Metabolism 79 1.36e-01 -0.097000 4.28e-01
Transcriptional regulation of granulopoiesis 44 2.66e-01 -0.096900 5.85e-01
Formation of definitive endoderm 9 6.15e-01 0.096700 8.38e-01
Signaling by ROBO receptors 189 2.26e-02 0.096200 1.69e-01
Integration of provirus 9 6.18e-01 0.096100 8.39e-01
VxPx cargo-targeting to cilium 19 4.70e-01 0.095700 7.56e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.95e-01 -0.095500 7.71e-01
Defective B3GAT3 causes JDSSDHD 11 5.85e-01 -0.095100 8.24e-01
tRNA modification in the nucleus and cytosol 43 2.81e-01 -0.095100 6.03e-01
PI-3K cascade:FGFR2 13 5.53e-01 0.095000 8.09e-01
Insulin receptor signalling cascade 40 2.99e-01 0.095000 6.18e-01
Regulation of BACH1 activity 11 5.86e-01 0.094800 8.24e-01
Signaling by Activin 14 5.40e-01 0.094600 7.99e-01
Glucagon signaling in metabolic regulation 26 4.04e-01 0.094500 6.88e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.99e-01 -0.094300 5.13e-01
CREB3 factors activate genes 6 6.89e-01 0.094300 8.67e-01
Impaired BRCA2 binding to RAD51 35 3.35e-01 -0.094200 6.42e-01
Apoptotic cleavage of cellular proteins 35 3.36e-01 0.094000 6.42e-01
ER to Golgi Anterograde Transport 145 5.10e-02 0.093900 2.59e-01
Defective C1GALT1C1 causes TNPS 10 6.08e-01 -0.093600 8.35e-01
Triglyceride catabolism 16 5.18e-01 0.093400 7.87e-01
Nucleotide catabolism 28 3.92e-01 0.093400 6.80e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.15e-01 0.093400 5.29e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 4.93e-01 -0.093300 7.70e-01
p38MAPK events 13 5.60e-01 0.093300 8.12e-01
Glucose metabolism 76 1.60e-01 -0.093200 4.61e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 4.40e-01 -0.093100 7.25e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.09e-01 -0.093000 5.21e-01
IRF3-mediated induction of type I IFN 12 5.78e-01 0.092700 8.21e-01
Peroxisomal protein import 58 2.23e-01 -0.092600 5.38e-01
CD28 dependent Vav1 pathway 12 5.79e-01 -0.092400 8.21e-01
Advanced glycosylation endproduct receptor signaling 12 5.80e-01 0.092300 8.21e-01
HDL assembly 6 6.97e-01 -0.091900 8.70e-01
Transport and synthesis of PAPS 6 6.97e-01 0.091800 8.70e-01
SLC transporter disorders 77 1.64e-01 -0.091700 4.65e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 5.69e-01 -0.091300 8.16e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.70e-01 -0.091000 4.72e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 7.24e-01 -0.091000 8.88e-01
Post-translational modification: synthesis of GPI-anchored proteins 59 2.27e-01 -0.090900 5.38e-01
Transcriptional regulation by RUNX2 92 1.32e-01 0.090800 4.24e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.20e-01 -0.090700 8.39e-01
Pentose phosphate pathway 13 5.72e-01 0.090600 8.16e-01
Signaling by BRAF and RAF1 fusions 60 2.25e-01 0.090500 5.38e-01
Diseases of mitotic cell cycle 38 3.36e-01 -0.090300 6.42e-01
Regulation of pyruvate metabolism 32 3.77e-01 0.090300 6.73e-01
PI3K/AKT activation 8 6.59e-01 0.090100 8.52e-01
Translation of Structural Proteins 9683701 29 4.01e-01 0.090100 6.86e-01
Branched-chain amino acid catabolism 21 4.75e-01 -0.090000 7.59e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 3.20e-02 0.090000 2.01e-01
G-protein mediated events 44 3.02e-01 -0.089900 6.19e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 2.82e-01 -0.089800 6.03e-01
Diseases of branched-chain amino acid catabolism 13 5.75e-01 -0.089800 8.18e-01
Regulation of signaling by NODAL 6 7.04e-01 -0.089600 8.73e-01
RNA Polymerase I Promoter Opening 17 5.23e-01 -0.089500 7.92e-01
Transcriptional regulation by RUNX1 170 4.46e-02 0.089300 2.43e-01
VEGFA-VEGFR2 Pathway 93 1.41e-01 0.088300 4.33e-01
Signaling by ERBB2 44 3.11e-01 0.088200 6.27e-01
Cargo recognition for clathrin-mediated endocytosis 89 1.51e-01 0.088100 4.48e-01
MyD88 cascade initiated on plasma membrane 95 1.38e-01 0.088000 4.29e-01
Toll Like Receptor 10 (TLR10) Cascade 95 1.38e-01 0.088000 4.29e-01
Toll Like Receptor 5 (TLR5) Cascade 95 1.38e-01 0.088000 4.29e-01
Acyl chain remodelling of PC 19 5.08e-01 0.087800 7.79e-01
N-glycan trimming and elongation in the cis-Golgi 5 7.34e-01 -0.087700 8.89e-01
p75NTR negatively regulates cell cycle via SC1 5 7.34e-01 0.087600 8.89e-01
Metabolism of amine-derived hormones 10 6.32e-01 0.087600 8.40e-01
RHOG GTPase cycle 71 2.02e-01 0.087500 5.14e-01
Ca2+ activated K+ channels 6 7.11e-01 -0.087300 8.80e-01
Cell-extracellular matrix interactions 16 5.46e-01 0.087300 8.04e-01
Inositol phosphate metabolism 42 3.31e-01 -0.086700 6.42e-01
Sensing of DNA Double Strand Breaks 6 7.13e-01 -0.086700 8.80e-01
Senescence-Associated Secretory Phenotype (SASP) 65 2.27e-01 0.086600 5.38e-01
Pausing and recovery of Tat-mediated HIV elongation 30 4.12e-01 -0.086500 6.95e-01
Tat-mediated HIV elongation arrest and recovery 30 4.12e-01 -0.086500 6.95e-01
TCF dependent signaling in response to WNT 153 6.48e-02 0.086500 2.99e-01
Phase 0 - rapid depolarisation 24 4.63e-01 0.086500 7.48e-01
Regulation of TP53 Degradation 35 3.78e-01 0.086200 6.73e-01
Striated Muscle Contraction 27 4.40e-01 0.085900 7.25e-01
Signaling by FGFR 73 2.05e-01 0.085800 5.18e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 6.39e-01 -0.085700 8.43e-01
Transcriptional Regulation by MECP2 49 2.99e-01 -0.085700 6.19e-01
Ribavirin ADME 11 6.23e-01 -0.085700 8.40e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 7.17e-01 0.085600 8.82e-01
Activated point mutants of FGFR2 7 6.95e-01 -0.085500 8.70e-01
RHOQ GTPase cycle 55 2.75e-01 0.085100 5.97e-01
Formation of the Early Elongation Complex 33 3.98e-01 -0.084900 6.85e-01
Formation of the HIV-1 Early Elongation Complex 33 3.98e-01 -0.084900 6.85e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 6.60e-01 -0.084800 8.52e-01
Peptide hormone metabolism 54 2.82e-01 0.084700 6.03e-01
Class I MHC mediated antigen processing & presentation 344 6.95e-03 0.084700 8.34e-02
Membrane Trafficking 577 5.09e-04 0.084700 1.76e-02
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.94e-01 0.084500 6.81e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 4.65e-01 -0.084400 7.50e-01
Signaling by Non-Receptor Tyrosine Kinases 47 3.18e-01 0.084200 6.34e-01
Signaling by PTK6 47 3.18e-01 0.084200 6.34e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 5.86e-01 0.084100 8.24e-01
Glyoxylate metabolism and glycine degradation 13 6.00e-01 -0.084000 8.33e-01
WNT ligand biogenesis and trafficking 19 5.26e-01 0.084000 7.92e-01
Formation of WDR5-containing histone-modifying complexes 42 3.47e-01 -0.083900 6.47e-01
B-WICH complex positively regulates rRNA expression 45 3.31e-01 0.083800 6.42e-01
Recognition of DNA damage by PCNA-containing replication complex 30 4.27e-01 -0.083800 7.12e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 6.82e-01 -0.083700 8.65e-01
Insulin processing 19 5.28e-01 0.083600 7.94e-01
NOD1/2 Signaling Pathway 36 3.85e-01 0.083600 6.78e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 7.23e-01 0.083500 8.87e-01
Metabolism of RNA 718 1.42e-04 0.083300 7.22e-03
FGFR1 ligand binding and activation 10 6.48e-01 0.083300 8.48e-01
Interleukin-23 signaling 7 7.03e-01 -0.083200 8.73e-01
Assembly of active LPL and LIPC lipase complexes 10 6.50e-01 0.083000 8.48e-01
Dual incision in TC-NER 63 2.55e-01 -0.082900 5.73e-01
Signaling by ERBB2 in Cancer 21 5.12e-01 0.082700 7.83e-01
FCERI mediated NF-kB activation 129 1.05e-01 -0.082700 3.82e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.33e-01 0.082600 4.24e-01
Metalloprotease DUBs 20 5.23e-01 0.082500 7.92e-01
Purine salvage 12 6.21e-01 -0.082500 8.39e-01
GPER1 signaling 38 3.80e-01 0.082400 6.73e-01
Leishmania infection 211 3.92e-02 -0.082300 2.27e-01
Parasitic Infection Pathways 211 3.92e-02 -0.082300 2.27e-01
MyD88 deficiency (TLR2/4) 14 5.95e-01 -0.082000 8.31e-01
Termination of translesion DNA synthesis 32 4.22e-01 -0.081900 7.08e-01
TRP channels 22 5.06e-01 -0.081900 7.78e-01
Negative regulation of the PI3K/AKT network 93 1.74e-01 0.081600 4.75e-01
ERBB2 Activates PTK6 Signaling 8 6.90e-01 -0.081400 8.67e-01
Defects in cobalamin (B12) metabolism 13 6.11e-01 -0.081400 8.36e-01
RET signaling 32 4.27e-01 0.081200 7.12e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.99e-01 -0.081100 5.13e-01
ISG15 antiviral mechanism 72 2.35e-01 0.080900 5.47e-01
Diseases of glycosylation 109 1.45e-01 -0.080800 4.37e-01
RIP-mediated NFkB activation via ZBP1 17 5.65e-01 0.080600 8.13e-01
Cellular responses to mechanical stimuli 82 2.07e-01 0.080600 5.19e-01
Response of endothelial cells to shear stress 82 2.07e-01 0.080600 5.19e-01
STING mediated induction of host immune responses 15 5.89e-01 0.080500 8.25e-01
Ub-specific processing proteases 153 8.58e-02 0.080500 3.41e-01
Mitochondrial calcium ion transport 22 5.14e-01 0.080400 7.84e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 3.93e-01 -0.080000 6.81e-01
Nucleosome assembly 38 3.93e-01 -0.080000 6.81e-01
Class A/1 (Rhodopsin-like receptors) 175 6.86e-02 0.079800 3.08e-01
Cargo trafficking to the periciliary membrane 47 3.47e-01 -0.079400 6.47e-01
Interleukin-2 signaling 11 6.49e-01 0.079300 8.48e-01
Cilium Assembly 186 6.21e-02 -0.079300 2.94e-01
IRAK4 deficiency (TLR2/4) 15 5.95e-01 -0.079300 8.31e-01
Telomere Maintenance 78 2.30e-01 -0.078700 5.39e-01
Translesion synthesis by POLI 17 5.74e-01 -0.078700 8.18e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 3.36e-01 -0.078600 6.42e-01
Signaling by Leptin 10 6.67e-01 0.078600 8.56e-01
HS-GAG biosynthesis 20 5.43e-01 0.078500 8.03e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 7.01e-01 0.078500 8.73e-01
Bicarbonate transporters 9 6.84e-01 -0.078400 8.65e-01
Glutamate and glutamine metabolism 12 6.40e-01 -0.078100 8.43e-01
AMPK inhibits chREBP transcriptional activation activity 6 7.41e-01 0.078100 8.91e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 6.26e-01 0.078000 8.40e-01
HIV Infection 213 4.98e-02 0.078000 2.57e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 4.83e-01 -0.077900 7.66e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.83e-01 -0.077900 7.66e-01
Heme signaling 45 3.66e-01 -0.077900 6.61e-01
Synthesis of substrates in N-glycan biosythesis 59 3.02e-01 -0.077700 6.19e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.37e-01 0.077700 6.42e-01
Nucleotide Excision Repair 108 1.63e-01 -0.077700 4.65e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 7.42e-01 0.077600 8.93e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 5.30e-01 0.077400 7.94e-01
Separation of Sister Chromatids 168 8.37e-02 0.077300 3.38e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 6.31e-01 0.077000 8.40e-01
N-Glycan antennae elongation 13 6.31e-01 -0.077000 8.40e-01
Germ layer formation at gastrulation 9 6.90e-01 0.076700 8.67e-01
Pre-NOTCH Expression and Processing 63 2.94e-01 -0.076500 6.17e-01
Nitric oxide stimulates guanylate cyclase 15 6.08e-01 -0.076400 8.35e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 7.27e-01 0.076100 8.88e-01
Zygotic genome activation (ZGA) 5 7.69e-01 -0.075900 9.08e-01
RNA Polymerase I Transcription Initiation 47 3.71e-01 -0.075500 6.67e-01
Membrane binding and targetting of GAG proteins 13 6.39e-01 0.075100 8.43e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 6.39e-01 0.075100 8.43e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 5.43e-01 0.074800 8.03e-01
Chromosome Maintenance 103 1.90e-01 -0.074700 5.03e-01
Recycling of bile acids and salts 10 6.82e-01 -0.074700 8.65e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.51e-01 -0.074700 8.96e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.51e-01 -0.074700 8.96e-01
Nuclear signaling by ERBB4 24 5.27e-01 -0.074700 7.92e-01
Evasion by RSV of host interferon responses 20 5.65e-01 0.074300 8.13e-01
IRAK2 mediated activation of TAK1 complex 10 6.84e-01 0.074200 8.65e-01
Regulated Necrosis 56 3.37e-01 0.074200 6.42e-01
Chromatin modifying enzymes 215 6.09e-02 -0.074200 2.89e-01
Chromatin organization 215 6.09e-02 -0.074200 2.89e-01
Interleukin-4 and Interleukin-13 signaling 93 2.17e-01 0.074000 5.33e-01
Regulation of TP53 Activity through Acetylation 29 4.91e-01 -0.074000 7.69e-01
Formation of annular gap junctions 10 6.86e-01 -0.073900 8.66e-01
Regulation of CDH19 Expression and Function 6 7.54e-01 -0.073900 8.97e-01
CASP8 activity is inhibited 11 6.73e-01 -0.073500 8.60e-01
Dimerization of procaspase-8 11 6.73e-01 -0.073500 8.60e-01
Regulation by c-FLIP 11 6.73e-01 -0.073500 8.60e-01
Apoptosis induced DNA fragmentation 10 6.88e-01 0.073400 8.67e-01
RAB GEFs exchange GTP for GDP on RABs 89 2.32e-01 0.073300 5.43e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 6.60e-01 -0.073300 8.52e-01
alpha-linolenic acid (ALA) metabolism 12 6.60e-01 -0.073300 8.52e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.35e-01 -0.073300 8.41e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.35e-01 -0.073300 8.41e-01
Disorders of transmembrane transporters 137 1.39e-01 0.073300 4.29e-01
PTK6 promotes HIF1A stabilization 6 7.56e-01 0.073100 8.98e-01
PKA activation 15 6.24e-01 0.073100 8.40e-01
Signalling to RAS 19 5.82e-01 0.073000 8.21e-01
Synthesis of PIPs at the plasma membrane 52 3.63e-01 -0.073000 6.57e-01
FGFRL1 modulation of FGFR1 signaling 7 7.38e-01 0.073000 8.91e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.91e-01 0.072800 5.04e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 1.91e-01 0.072800 5.04e-01
Mitotic Anaphase 211 6.85e-02 0.072800 3.08e-01
G beta:gamma signalling through PLC beta 17 6.04e-01 0.072700 8.33e-01
Presynaptic function of Kainate receptors 17 6.04e-01 0.072700 8.33e-01
Receptor-type tyrosine-protein phosphatases 12 6.63e-01 0.072600 8.54e-01
Myogenesis 21 5.65e-01 0.072600 8.13e-01
Constitutive Signaling by Aberrant PI3K in Cancer 59 3.36e-01 0.072400 6.42e-01
Switching of origins to a post-replicative state 79 2.66e-01 0.072400 5.85e-01
SHC1 events in ERBB2 signaling 17 6.06e-01 0.072300 8.34e-01
G alpha (q) signalling events 139 1.42e-01 0.072200 4.33e-01
mRNA Splicing - Minor Pathway 50 3.78e-01 0.072100 6.73e-01
Mitotic Metaphase and Anaphase 212 7.08e-02 0.072000 3.15e-01
Processing of DNA double-strand break ends 69 3.01e-01 -0.072000 6.19e-01
Depolymerization of the Nuclear Lamina 15 6.30e-01 0.071900 8.40e-01
Transport of fatty acids 5 7.81e-01 -0.071900 9.14e-01
FLT3 Signaling 38 4.44e-01 0.071800 7.29e-01
RAB geranylgeranylation 61 3.32e-01 0.071800 6.42e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 4.16e-02 0.071400 2.35e-01
Drug ADME 59 3.43e-01 -0.071400 6.46e-01
Downstream signal transduction 27 5.23e-01 0.071100 7.92e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.84e-01 -0.070900 8.65e-01
TRAIL signaling 8 7.28e-01 -0.070900 8.88e-01
Glycosaminoglycan metabolism 98 2.26e-01 -0.070800 5.38e-01
Aspartate and asparagine metabolism 9 7.13e-01 -0.070700 8.80e-01
Retrograde neurotrophin signalling 12 6.72e-01 -0.070700 8.60e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.59e-01 -0.070600 8.52e-01
TP53 Regulates Metabolic Genes 78 2.82e-01 0.070500 6.03e-01
DNA Damage Bypass 47 4.04e-01 -0.070400 6.88e-01
Regulation of IFNA/IFNB signaling 12 6.73e-01 0.070300 8.60e-01
HCMV Early Events 84 2.67e-01 -0.070100 5.86e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 6.62e-01 0.070100 8.53e-01
Transport to the Golgi and subsequent modification 171 1.14e-01 0.070000 3.93e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 3.67e-01 0.069600 6.63e-01
Negative regulation of FLT3 15 6.41e-01 -0.069600 8.44e-01
FGFR2 mutant receptor activation 23 5.64e-01 -0.069500 8.13e-01
Fatty acid metabolism 155 1.36e-01 -0.069400 4.28e-01
RHO GTPases activate CIT 18 6.10e-01 0.069400 8.36e-01
Generic Transcription Pathway 1088 1.13e-04 -0.069300 6.22e-03
FOXO-mediated transcription 58 3.61e-01 0.069300 6.56e-01
Interleukin-10 signaling 38 4.61e-01 0.069100 7.45e-01
Asparagine N-linked glycosylation 286 4.48e-02 0.069000 2.43e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 1.76e-02 0.068800 1.47e-01
HCMV Late Events 67 3.30e-01 -0.068800 6.42e-01
O-glycosylation of TSR domain-containing proteins 28 5.29e-01 -0.068700 7.94e-01
Signaling by FGFR1 in disease 32 5.02e-01 0.068600 7.74e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 7.71e-01 -0.068500 9.09e-01
Condensation of Prometaphase Chromosomes 11 6.94e-01 -0.068500 8.69e-01
MyD88 dependent cascade initiated on endosome 101 2.36e-01 0.068300 5.48e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 5.32e-01 0.068200 7.95e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 5.98e-01 -0.068100 8.33e-01
Adipogenesis 96 2.50e-01 -0.068000 5.66e-01
Signaling by KIT in disease 20 6.00e-01 0.067700 8.33e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.00e-01 0.067700 8.33e-01
CaM pathway 28 5.35e-01 -0.067700 7.95e-01
Calmodulin induced events 28 5.35e-01 -0.067700 7.95e-01
Signaling by NTRKs 117 2.08e-01 0.067400 5.19e-01
Protein hydroxylation 17 6.31e-01 0.067300 8.40e-01
Nef Mediated CD4 Down-regulation 9 7.27e-01 0.067300 8.88e-01
RNA Polymerase I Transcription Termination 30 5.24e-01 0.067200 7.92e-01
Toll Like Receptor 2 (TLR2) Cascade 109 2.26e-01 0.067100 5.38e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 2.26e-01 0.067100 5.38e-01
Miscellaneous transport and binding events 20 6.03e-01 0.067100 8.33e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 7.00e-01 -0.067100 8.73e-01
Mitotic Telophase/Cytokinesis 13 6.76e-01 -0.066900 8.61e-01
Signaling by ERBB2 KD Mutants 20 6.05e-01 0.066800 8.33e-01
CaMK IV-mediated phosphorylation of CREB 9 7.29e-01 0.066800 8.88e-01
RHOV GTPase cycle 36 4.88e-01 -0.066700 7.68e-01
HIV elongation arrest and recovery 32 5.14e-01 -0.066700 7.84e-01
Pausing and recovery of HIV elongation 32 5.14e-01 -0.066700 7.84e-01
Sphingolipid metabolism 91 2.75e-01 0.066300 5.97e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 6.38e-01 -0.065900 8.43e-01
Apoptotic factor-mediated response 19 6.19e-01 0.065800 8.39e-01
Nucleotide salvage 21 6.02e-01 -0.065700 8.33e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 2.56e-01 0.065700 5.73e-01
Neurotransmitter release cycle 38 4.85e-01 -0.065400 7.66e-01
Diseases of Mismatch Repair (MMR) 5 8.00e-01 -0.065400 9.24e-01
TNFR1-induced proapoptotic signaling 24 5.80e-01 -0.065200 8.21e-01
Plasma lipoprotein clearance 33 5.18e-01 -0.065100 7.87e-01
Developmental Biology 929 7.84e-04 0.065000 2.29e-02
Signaling by SCF-KIT 40 4.78e-01 0.064900 7.60e-01
Organelle biogenesis and maintenance 277 6.35e-02 -0.064800 2.96e-01
Formation of Incision Complex in GG-NER 43 4.63e-01 0.064700 7.47e-01
Mitotic Prophase 96 2.73e-01 -0.064700 5.96e-01
G alpha (i) signalling events 194 1.21e-01 0.064600 4.04e-01
SARS-CoV-1 Infection 138 1.90e-01 0.064600 5.03e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 4.92e-01 0.064400 7.69e-01
Biosynthesis of maresin-like SPMs 5 8.03e-01 0.064400 9.27e-01
Mitochondrial translation termination 90 2.91e-01 0.064400 6.15e-01
Glycosphingolipid metabolism 46 4.50e-01 -0.064400 7.36e-01
Signaling by ERBB4 45 4.56e-01 0.064200 7.40e-01
Mitochondrial translation initiation 90 2.93e-01 0.064100 6.17e-01
Neutrophil degranulation 458 1.87e-02 0.064100 1.53e-01
rRNA processing 213 1.08e-01 0.063800 3.84e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 6.31e-01 -0.063600 8.40e-01
Dectin-2 family 19 6.32e-01 0.063500 8.40e-01
Oncogenic MAPK signaling 76 3.39e-01 0.063400 6.43e-01
Post NMDA receptor activation events 64 3.81e-01 0.063400 6.73e-01
FLT3 signaling in disease 27 5.71e-01 0.063000 8.16e-01
PECAM1 interactions 12 7.06e-01 0.062900 8.76e-01
Signaling by Receptor Tyrosine Kinases 449 2.31e-02 0.062500 1.71e-01
Downstream signaling of activated FGFR2 20 6.28e-01 0.062500 8.40e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 4.08e-01 0.062300 6.92e-01
Signaling by NTRK3 (TRKC) 16 6.66e-01 -0.062300 8.56e-01
NGF-stimulated transcription 32 5.42e-01 -0.062300 8.01e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.75e-01 -0.062300 8.18e-01
Phase 4 - resting membrane potential 9 7.48e-01 -0.061900 8.96e-01
Mitochondrial translation 96 2.94e-01 0.061900 6.17e-01
FGFR4 ligand binding and activation 5 8.11e-01 0.061900 9.32e-01
Signaling by NOTCH3 44 4.78e-01 0.061800 7.60e-01
Metabolism of carbohydrates 241 9.98e-02 -0.061600 3.74e-01
Cargo concentration in the ER 31 5.54e-01 0.061400 8.09e-01
DAG and IP3 signaling 34 5.36e-01 -0.061400 7.95e-01
Sensory perception of taste 22 6.19e-01 0.061300 8.39e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 6.53e-01 -0.061200 8.49e-01
Opioid Signalling 75 3.61e-01 0.061100 6.56e-01
Regulation of NF-kappa B signaling 18 6.54e-01 0.061000 8.51e-01
Oxidative Stress Induced Senescence 77 3.55e-01 -0.060900 6.53e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 6.13e-01 0.060900 8.36e-01
Loss of Function of TGFBR1 in Cancer 7 7.81e-01 0.060800 9.14e-01
Regulation of lipid metabolism by PPARalpha 107 2.78e-01 -0.060700 6.01e-01
RAF-independent MAPK1/3 activation 22 6.23e-01 0.060500 8.40e-01
Cytokine Signaling in Immune system 670 7.81e-03 0.060300 8.83e-02
HATs acetylate histones 92 3.18e-01 0.060200 6.34e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 2.87e-01 0.060200 6.08e-01
RUNX2 regulates osteoblast differentiation 21 6.34e-01 -0.060000 8.40e-01
Complex I biogenesis 66 4.00e-01 0.060000 6.85e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 5.24e-01 -0.059700 7.92e-01
Biological oxidations 146 2.13e-01 0.059700 5.28e-01
RUNX2 regulates bone development 26 5.99e-01 -0.059600 8.33e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 7.71e-01 0.059500 9.09e-01
Translation 293 8.00e-02 0.059500 3.31e-01
Extracellular matrix organization 222 1.28e-01 -0.059300 4.19e-01
EGFR Transactivation by Gastrin 7 7.86e-01 0.059300 9.18e-01
Processing and activation of SUMO 10 7.46e-01 -0.059100 8.95e-01
Interferon Signaling 240 1.15e-01 0.059100 3.93e-01
Centrosome maturation 81 3.59e-01 -0.059000 6.56e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.59e-01 -0.059000 6.56e-01
Biosynthesis of DHA-derived SPMs 15 6.93e-01 -0.059000 8.68e-01
TYSND1 cleaves peroxisomal proteins 7 7.87e-01 -0.058900 9.18e-01
Basigin interactions 23 6.25e-01 0.058900 8.40e-01
Reproduction 85 3.48e-01 -0.058800 6.48e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 4.51e-01 -0.058800 7.36e-01
Platelet homeostasis 69 3.99e-01 0.058800 6.85e-01
G alpha (s) signalling events 97 3.18e-01 -0.058700 6.34e-01
Caspase activation via Death Receptors in the presence of ligand 16 6.84e-01 -0.058700 8.65e-01
Mitochondrial translation elongation 90 3.37e-01 0.058500 6.42e-01
ZBP1(DAI) mediated induction of type I IFNs 20 6.51e-01 0.058500 8.48e-01
WNT mediated activation of DVL 8 7.75e-01 -0.058500 9.11e-01
Signaling by NTRK1 (TRKA) 102 3.08e-01 0.058400 6.25e-01
Metabolism of Angiotensinogen to Angiotensins 12 7.28e-01 -0.058100 8.88e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 4.96e-01 0.058000 7.71e-01
Assembly and cell surface presentation of NMDA receptors 34 5.59e-01 0.057900 8.12e-01
Nucleotide-like (purinergic) receptors 13 7.18e-01 -0.057900 8.82e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 6.46e-01 -0.057800 8.48e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.44e-01 0.057700 6.46e-01
RUNX3 Regulates Immune Response and Cell Migration 6 8.07e-01 0.057700 9.30e-01
Cellular responses to stimuli 779 6.23e-03 0.057600 7.87e-02
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 8.24e-01 -0.057600 9.36e-01
CTLA4 inhibitory signaling 21 6.48e-01 0.057500 8.48e-01
Free fatty acids regulate insulin secretion 10 7.53e-01 -0.057500 8.96e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 7.79e-01 -0.057400 9.13e-01
APC-Cdc20 mediated degradation of Nek2A 26 6.13e-01 0.057300 8.36e-01
RUNX3 regulates WNT signaling 8 7.80e-01 -0.057100 9.14e-01
SMAC (DIABLO) binds to IAPs 7 7.94e-01 -0.057000 9.21e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 7.94e-01 -0.057000 9.21e-01
SMAC, XIAP-regulated apoptotic response 7 7.94e-01 -0.057000 9.21e-01
PI3K events in ERBB4 signaling 6 8.09e-01 -0.057000 9.31e-01
Translesion synthesis by REV1 16 6.94e-01 -0.056800 8.69e-01
Defensins 8 7.81e-01 0.056800 9.14e-01
Toll Like Receptor 4 (TLR4) Cascade 138 2.51e-01 0.056600 5.67e-01
Muscle contraction 145 2.40e-01 0.056600 5.55e-01
Stimuli-sensing channels 81 3.79e-01 -0.056500 6.73e-01
Plasma lipoprotein assembly 10 7.58e-01 -0.056300 8.99e-01
Synthesis, secretion, and deacylation of Ghrelin 11 7.47e-01 0.056200 8.95e-01
Erythropoietin activates STAT5 6 8.12e-01 0.056200 9.32e-01
HSF1 activation 26 6.21e-01 0.056100 8.39e-01
Ion transport by P-type ATPases 43 5.26e-01 -0.055800 7.92e-01
Sensory processing of sound by inner hair cells of the cochlea 54 4.78e-01 -0.055800 7.60e-01
G2/M DNA damage checkpoint 66 4.33e-01 -0.055800 7.17e-01
Signal regulatory protein family interactions 13 7.28e-01 0.055700 8.88e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 8.13e-01 -0.055700 9.32e-01
Tie2 Signaling 16 7.00e-01 0.055600 8.73e-01
Uptake and function of diphtheria toxin 6 8.14e-01 0.055600 9.32e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 5.34e-01 -0.055500 7.95e-01
HIV Transcription Elongation 42 5.34e-01 -0.055500 7.95e-01
Tat-mediated elongation of the HIV-1 transcript 42 5.34e-01 -0.055500 7.95e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.12e-01 0.055400 8.36e-01
Mitochondrial protein degradation 96 3.50e-01 0.055200 6.49e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 5.61e-01 -0.055200 8.12e-01
WNT5A-dependent internalization of FZD4 13 7.31e-01 -0.055100 8.89e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 2.59e-01 0.055100 5.78e-01
Phase II - Conjugation of compounds 71 4.23e-01 0.055000 7.08e-01
S Phase 150 2.46e-01 -0.054900 5.61e-01
Signaling by FGFR2 IIIa TM 18 6.88e-01 -0.054700 8.67e-01
RNA Polymerase I Promoter Clearance 64 4.52e-01 -0.054300 7.37e-01
RNA Polymerase I Transcription 64 4.52e-01 -0.054300 7.37e-01
Reduction of cytosolic Ca++ levels 9 7.78e-01 0.054200 9.13e-01
Toll Like Receptor 9 (TLR9) Cascade 108 3.31e-01 0.054100 6.42e-01
Mitochondrial iron-sulfur cluster biogenesis 13 7.37e-01 -0.053900 8.89e-01
NRAGE signals death through JNK 52 5.02e-01 -0.053900 7.74e-01
Negative regulators of DDX58/IFIH1 signaling 34 5.87e-01 0.053800 8.25e-01
Cell-Cell communication 114 3.21e-01 -0.053800 6.36e-01
Influenza Viral RNA Transcription and Replication 135 2.84e-01 -0.053500 6.05e-01
Dissolution of Fibrin Clot 12 7.49e-01 -0.053400 8.96e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 7.94e-01 0.053300 9.21e-01
Signaling by VEGF 100 3.59e-01 0.053100 6.56e-01
Signaling by NOTCH2 33 5.98e-01 -0.053100 8.33e-01
Xenobiotics 12 7.51e-01 -0.053000 8.96e-01
Cellular response to starvation 148 2.67e-01 0.052800 5.86e-01
Intra-Golgi traffic 43 5.50e-01 0.052700 8.07e-01
GPCR ligand binding 241 1.59e-01 0.052700 4.61e-01
PI3K/AKT Signaling in Cancer 85 4.04e-01 0.052300 6.88e-01
EPH-ephrin mediated repulsion of cells 43 5.53e-01 -0.052300 8.09e-01
Regulation of TNFR1 signaling 47 5.35e-01 0.052300 7.95e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 3.49e-01 -0.052200 6.48e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 8.40e-01 -0.052000 9.44e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 8.12e-01 -0.051900 9.32e-01
Translesion synthesis by POLK 17 7.11e-01 -0.051900 8.80e-01
TAK1-dependent IKK and NF-kappa-B activation 43 5.56e-01 0.051800 8.10e-01
SUMOylation of intracellular receptors 26 6.48e-01 0.051700 8.48e-01
Meiosis 67 4.64e-01 -0.051700 7.49e-01
Interleukin-20 family signaling 17 7.14e-01 0.051300 8.80e-01
mRNA Capping 29 6.33e-01 -0.051300 8.40e-01
RUNX1 regulates estrogen receptor mediated transcription 6 8.28e-01 0.051100 9.38e-01
Synthesis of GDP-mannose 6 8.28e-01 -0.051100 9.38e-01
Listeria monocytogenes entry into host cells 17 7.15e-01 0.051100 8.81e-01
Prolactin receptor signaling 12 7.60e-01 0.050900 9.00e-01
FOXO-mediated transcription of cell cycle genes 15 7.33e-01 0.050900 8.89e-01
Activated NTRK3 signals through PI3K 5 8.44e-01 0.050800 9.44e-01
Formation of the beta-catenin:TCF transactivating complex 44 5.60e-01 -0.050800 8.12e-01
Tryptophan catabolism 12 7.61e-01 -0.050700 9.01e-01
Epigenetic regulation of gene expression 263 1.57e-01 -0.050700 4.59e-01
MECP2 regulates neuronal receptors and channels 14 7.43e-01 -0.050600 8.93e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 4.52e-01 -0.050500 7.37e-01
tRNA Aminoacylation 42 5.72e-01 -0.050400 8.16e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 3.60e-01 0.050300 6.56e-01
Cellular responses to stress 698 2.40e-02 0.050100 1.72e-01
Serine biosynthesis 8 8.06e-01 0.050100 9.30e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 4.36e-01 -0.050000 7.22e-01
Intrinsic Pathway for Apoptosis 54 5.25e-01 0.050000 7.92e-01
O-linked glycosylation of mucins 47 5.56e-01 0.049700 8.10e-01
Transport of vitamins, nucleosides, and related molecules 32 6.27e-01 -0.049600 8.40e-01
PI5P Regulates TP53 Acetylation 8 8.08e-01 0.049500 9.31e-01
rRNA processing in the nucleus and cytosol 189 2.41e-01 0.049500 5.55e-01
Regulation of gene expression in beta cells 8 8.09e-01 0.049400 9.31e-01
FasL/ CD95L signaling 5 8.49e-01 -0.049300 9.47e-01
Diseases associated with the TLR signaling cascade 29 6.46e-01 -0.049300 8.48e-01
Diseases of Immune System 29 6.46e-01 -0.049300 8.48e-01
Processing of Capped Intronless Pre-mRNA 29 6.47e-01 0.049200 8.48e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 8.00e-01 0.048900 9.24e-01
PPARA activates gene expression 105 3.87e-01 -0.048900 6.78e-01
Biosynthesis of E-series 18(S)-resolvins 5 8.50e-01 -0.048800 9.47e-01
Cell Cycle, Mitotic 488 6.63e-02 -0.048500 3.04e-01
Diseases of carbohydrate metabolism 29 6.52e-01 -0.048400 8.48e-01
RNA Polymerase II Transcription 1206 4.96e-03 -0.048000 6.80e-02
Glycosphingolipid biosynthesis 15 7.49e-01 0.047700 8.96e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 8.27e-01 -0.047600 9.38e-01
Downregulation of ERBB2:ERBB3 signaling 12 7.76e-01 0.047400 9.13e-01
SARS-CoV-1 activates/modulates innate immune responses 40 6.04e-01 -0.047400 8.33e-01
Activation of kainate receptors upon glutamate binding 26 6.76e-01 0.047300 8.61e-01
ECM proteoglycans 48 5.71e-01 0.047300 8.16e-01
SARS-CoV Infections 433 9.18e-02 -0.047300 3.54e-01
VEGFR2 mediated cell proliferation 18 7.29e-01 -0.047200 8.88e-01
HSF1-dependent transactivation 30 6.57e-01 0.046800 8.52e-01
Nephron development 5 8.57e-01 -0.046600 9.49e-01
Small interfering RNA (siRNA) biogenesis 9 8.10e-01 0.046400 9.31e-01
EGFR interacts with phospholipase C-gamma 7 8.32e-01 0.046300 9.40e-01
RORA activates gene expression 18 7.34e-01 -0.046200 8.89e-01
Activation of HOX genes during differentiation 70 5.04e-01 -0.046200 7.77e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 5.04e-01 -0.046200 7.77e-01
Deubiquitination 225 2.36e-01 0.045900 5.48e-01
ERBB2 Regulates Cell Motility 10 8.02e-01 0.045800 9.26e-01
Assembly of the pre-replicative complex 87 4.61e-01 0.045800 7.45e-01
Cellular Senescence 143 3.45e-01 -0.045700 6.46e-01
Gene expression (Transcription) 1413 4.09e-03 -0.045600 6.32e-02
SARS-CoV-2-host interactions 183 2.90e-01 -0.045400 6.14e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 3.02e-01 0.044700 6.19e-01
Metabolism of nucleotides 85 4.76e-01 -0.044700 7.60e-01
Activation of NMDA receptors and postsynaptic events 74 5.07e-01 0.044600 7.78e-01
Vitamin B1 (thiamin) metabolism 5 8.64e-01 0.044400 9.51e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.24e-01 0.044100 7.09e-01
Defective Intrinsic Pathway for Apoptosis 24 7.08e-01 -0.044100 8.78e-01
Defective B3GALTL causes PpS 27 6.94e-01 -0.043700 8.69e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 7.12e-01 0.043500 8.80e-01
Collagen chain trimerization 29 6.87e-01 -0.043300 8.66e-01
Complex IV assembly 45 6.16e-01 0.043200 8.38e-01
Synthesis of DNA 108 4.38e-01 -0.043200 7.24e-01
Pyruvate metabolism 44 6.20e-01 0.043100 8.39e-01
TNFR2 non-canonical NF-kB pathway 84 4.96e-01 0.043000 7.71e-01
Mitotic G2-G2/M phases 179 3.23e-01 0.042800 6.37e-01
Cell Cycle 611 7.10e-02 -0.042800 3.15e-01
Postmitotic nuclear pore complex (NPC) reformation 27 7.02e-01 -0.042500 8.73e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 6.26e-01 -0.042500 8.40e-01
G2/M Transition 177 3.33e-01 0.042200 6.42e-01
FGFR1 mutant receptor activation 25 7.16e-01 0.042100 8.81e-01
P2Y receptors 10 8.18e-01 -0.042000 9.34e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 4.89e-01 -0.042000 7.68e-01
Amplification of signal from the kinetochores 91 4.89e-01 -0.042000 7.68e-01
Cap-dependent Translation Initiation 118 4.32e-01 0.041900 7.17e-01
Eukaryotic Translation Initiation 118 4.32e-01 0.041900 7.17e-01
PIP3 activates AKT signaling 235 2.70e-01 0.041700 5.91e-01
SIRT1 negatively regulates rRNA expression 22 7.35e-01 -0.041700 8.89e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 8.29e-01 -0.041500 9.39e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 4.45e-01 0.041400 7.29e-01
Nonsense-Mediated Decay (NMD) 114 4.45e-01 0.041400 7.29e-01
Synthesis of diphthamide-EEF2 8 8.39e-01 0.041400 9.44e-01
Processing of SMDT1 15 7.82e-01 -0.041200 9.15e-01
DNA Replication 128 4.22e-01 -0.041100 7.08e-01
SUMOylation of transcription cofactors 44 6.39e-01 0.040800 8.43e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 7.84e-01 0.040800 9.17e-01
TGF-beta receptor signaling activates SMADs 45 6.37e-01 0.040700 8.43e-01
Androgen biosynthesis 5 8.75e-01 -0.040600 9.57e-01
Neddylation 215 3.05e-01 0.040600 6.22e-01
STAT5 Activation 7 8.53e-01 0.040600 9.47e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 5.35e-01 0.040400 7.95e-01
Heparan sulfate/heparin (HS-GAG) metabolism 40 6.60e-01 -0.040300 8.52e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 7.28e-01 0.040200 8.88e-01
Anchoring of the basal body to the plasma membrane 97 4.96e-01 -0.040000 7.71e-01
NCAM1 interactions 27 7.20e-01 -0.039900 8.84e-01
Interleukin-2 family signaling 38 6.72e-01 -0.039600 8.60e-01
ChREBP activates metabolic gene expression 7 8.57e-01 0.039400 9.49e-01
Rab regulation of trafficking 122 4.54e-01 0.039300 7.38e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 8.24e-01 -0.038700 9.36e-01
Synthesis of UDP-N-acetyl-glucosamine 8 8.51e-01 -0.038500 9.47e-01
Ephrin signaling 18 7.79e-01 -0.038300 9.13e-01
Phospholipid metabolism 183 3.77e-01 -0.037900 6.73e-01
Signaling by Nuclear Receptors 214 3.50e-01 -0.037000 6.49e-01
Transcriptional Regulation by NPAS4 27 7.39e-01 0.037000 8.91e-01
RAC3 GTPase cycle 88 5.49e-01 0.037000 8.06e-01
SARS-CoV-1 modulates host translation machinery 36 7.02e-01 0.036800 8.73e-01
Mitotic Prometaphase 193 3.79e-01 -0.036800 6.73e-01
Lewis blood group biosynthesis 14 8.12e-01 0.036600 9.32e-01
Protein localization 157 4.31e-01 -0.036400 7.17e-01
NOTCH2 intracellular domain regulates transcription 11 8.35e-01 -0.036400 9.42e-01
TNFR1-induced NF-kappa-B signaling pathway 32 7.22e-01 0.036400 8.86e-01
Degradation of the extracellular matrix 99 5.32e-01 -0.036300 7.95e-01
Signaling by NOTCH 175 4.08e-01 0.036300 6.92e-01
IRS-related events triggered by IGF1R 37 7.03e-01 0.036300 8.73e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 8.68e-01 0.036200 9.53e-01
Voltage gated Potassium channels 26 7.49e-01 -0.036200 8.96e-01
FGFR2c ligand binding and activation 5 8.89e-01 0.036000 9.63e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 7.33e-01 0.035900 8.89e-01
Elevation of cytosolic Ca2+ levels 13 8.23e-01 -0.035900 9.36e-01
Collagen degradation 44 6.81e-01 0.035900 8.65e-01
Butyrophilin (BTN) family interactions 9 8.52e-01 0.035800 9.47e-01
SUMOylation of immune response proteins 12 8.31e-01 -0.035600 9.40e-01
Visual phototransduction 60 6.33e-01 0.035600 8.40e-01
SHC-mediated cascade:FGFR2 13 8.24e-01 0.035600 9.36e-01
MTOR signalling 39 7.03e-01 -0.035300 8.73e-01
AURKA Activation by TPX2 72 6.05e-01 -0.035300 8.33e-01
Transport of Mature Transcript to Cytoplasm 81 5.86e-01 0.035100 8.24e-01
TNF signaling 56 6.51e-01 0.034900 8.48e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 8.17e-01 0.034600 9.33e-01
RHO GTPase Effectors 258 3.40e-01 0.034500 6.43e-01
Transcriptional regulation of white adipocyte differentiation 77 6.04e-01 -0.034100 8.33e-01
G alpha (12/13) signalling events 68 6.27e-01 0.034100 8.40e-01
Mitochondrial biogenesis 91 5.74e-01 -0.034100 8.18e-01
Integrin cell surface interactions 68 6.27e-01 -0.034100 8.40e-01
RNA polymerase II transcribes snRNA genes 71 6.19e-01 0.034100 8.39e-01
Chondroitin sulfate biosynthesis 12 8.38e-01 0.034000 9.44e-01
Diseases of metabolism 208 4.09e-01 -0.033200 6.93e-01
Synthesis of PA 31 7.52e-01 -0.032800 8.96e-01
Uptake and actions of bacterial toxins 28 7.64e-01 -0.032800 9.04e-01
Cardiac conduction 89 5.93e-01 0.032800 8.29e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 7.78e-01 -0.032600 9.13e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 1.67e-01 0.032400 4.69e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 6.75e-01 -0.032400 8.60e-01
Signal Transduction 2058 1.65e-02 0.032000 1.43e-01
IGF1R signaling cascade 38 7.33e-01 0.032000 8.89e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 8.76e-01 -0.031800 9.58e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 6.41e-01 0.031700 8.44e-01
Metabolism of proteins 1777 2.63e-02 0.031700 1.82e-01
Beta-oxidation of very long chain fatty acids 11 8.56e-01 -0.031600 9.49e-01
Regulation of TP53 Activity through Phosphorylation 88 6.09e-01 -0.031600 8.35e-01
RNA Polymerase II Pre-transcription Events 77 6.32e-01 0.031500 8.40e-01
ESR-mediated signaling 160 4.92e-01 0.031500 7.69e-01
CLEC7A/inflammasome pathway 6 8.94e-01 -0.031500 9.64e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 7.86e-01 -0.031300 9.18e-01
Signaling by Rho GTPases 608 1.90e-01 0.031100 5.03e-01
tRNA processing 128 5.46e-01 -0.030900 8.04e-01
G1/S Transition 120 5.60e-01 -0.030800 8.12e-01
Interleukin-9 signaling 8 8.80e-01 -0.030800 9.59e-01
Miscellaneous substrates 7 8.88e-01 0.030700 9.62e-01
Sensory processing of sound by outer hair cells of the cochlea 41 7.35e-01 0.030500 8.89e-01
Intracellular signaling by second messengers 268 3.91e-01 0.030500 6.79e-01
Mitochondrial unfolded protein response (UPRmt) 17 8.28e-01 0.030400 9.38e-01
Post-translational protein phosphorylation 70 6.60e-01 0.030400 8.52e-01
ALK mutants bind TKIs 11 8.62e-01 0.030300 9.51e-01
Glycolysis 68 6.67e-01 -0.030200 8.56e-01
Vesicle-mediated transport 669 1.83e-01 0.030200 4.91e-01
Transport of nucleotide sugars 9 8.76e-01 0.029900 9.58e-01
Signaling by MAPK mutants 6 8.99e-01 0.029800 9.64e-01
Phosphorylation of the APC/C 20 8.18e-01 -0.029700 9.34e-01
RNA Polymerase III Abortive And Retractive Initiation 41 7.45e-01 0.029300 8.95e-01
RNA Polymerase III Transcription 41 7.45e-01 0.029300 8.95e-01
Inhibition of DNA recombination at telomere 33 7.72e-01 -0.029100 9.10e-01
Glucagon-type ligand receptors 20 8.22e-01 -0.029000 9.36e-01
Protein methylation 15 8.47e-01 -0.028800 9.46e-01
Negative epigenetic regulation of rRNA expression 63 6.92e-01 -0.028800 8.68e-01
Metabolism of porphyrins 23 8.13e-01 -0.028500 9.32e-01
SARS-CoV-1-host interactions 95 6.32e-01 0.028500 8.40e-01
Toll-like Receptor Cascades 162 5.32e-01 0.028400 7.95e-01
Detoxification of Reactive Oxygen Species 30 7.88e-01 -0.028400 9.18e-01
Mitotic Spindle Checkpoint 108 6.12e-01 -0.028300 8.36e-01
Estrogen-dependent gene expression 97 6.32e-01 -0.028100 8.40e-01
Biosynthesis of maresins 7 8.99e-01 0.027800 9.64e-01
Keratan sulfate degradation 9 8.87e-01 -0.027500 9.62e-01
Biosynthesis of EPA-derived SPMs 6 9.07e-01 0.027400 9.68e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 8.41e-01 0.027400 9.44e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 9.01e-01 -0.027200 9.65e-01
MicroRNA (miRNA) biogenesis 24 8.18e-01 0.027200 9.34e-01
CD28 co-stimulation 33 7.88e-01 -0.027100 9.18e-01
RHOC GTPase cycle 72 6.91e-01 -0.027100 8.67e-01
Ca-dependent events 30 7.99e-01 -0.026900 9.24e-01
RHO GTPase cycle 412 3.50e-01 0.026800 6.49e-01
Signaling by FGFR in disease 52 7.39e-01 -0.026700 8.91e-01
Synthesis of PIPs at the late endosome membrane 11 8.79e-01 0.026600 9.59e-01
NoRC negatively regulates rRNA expression 60 7.23e-01 -0.026400 8.87e-01
Hydrolysis of LPC 8 8.97e-01 -0.026400 9.64e-01
Respiratory electron transport 149 5.79e-01 0.026300 8.21e-01
Diseases associated with glycosaminoglycan metabolism 25 8.20e-01 -0.026300 9.35e-01
IRS-mediated signalling 35 7.91e-01 0.025900 9.19e-01
Meiotic synapsis 43 7.71e-01 -0.025700 9.09e-01
PTEN Regulation 127 6.18e-01 0.025700 8.39e-01
Transmission across Chemical Synapses 188 5.54e-01 0.025000 8.09e-01
SLC-mediated transmembrane transport 175 5.70e-01 -0.024900 8.16e-01
Potassium Channels 64 7.31e-01 0.024800 8.89e-01
Translesion Synthesis by POLH 18 8.55e-01 -0.024800 9.49e-01
RAS signaling downstream of NF1 loss-of-function variants 7 9.09e-01 0.024800 9.69e-01
TBC/RABGAPs 45 7.75e-01 0.024700 9.11e-01
Interleukin receptor SHC signaling 23 8.38e-01 -0.024600 9.44e-01
Recruitment of NuMA to mitotic centrosomes 88 6.90e-01 -0.024600 8.67e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 6.81e-01 0.024500 8.65e-01
SHC1 events in ERBB4 signaling 10 8.93e-01 0.024500 9.64e-01
Synthesis of IP3 and IP4 in the cytosol 22 8.43e-01 -0.024400 9.44e-01
Class B/2 (Secretin family receptors) 55 7.55e-01 -0.024300 8.97e-01
cGMP effects 12 8.84e-01 0.024300 9.62e-01
Repression of WNT target genes 14 8.75e-01 -0.024300 9.57e-01
Regulation of TP53 Activity 153 6.05e-01 -0.024200 8.33e-01
Diseases associated with glycosylation precursor biosynthesis 15 8.71e-01 0.024200 9.55e-01
Circadian Clock 67 7.33e-01 0.024100 8.89e-01
Signaling by NOTCH1 68 7.32e-01 0.024000 8.89e-01
Signaling by TGFB family members 139 6.27e-01 0.023900 8.40e-01
Transport of small molecules 558 3.37e-01 0.023800 6.42e-01
FRS-mediated FGFR2 signaling 15 8.74e-01 0.023700 9.57e-01
Glycine degradation 7 9.14e-01 0.023700 9.70e-01
RHO GTPases Activate Formins 128 6.45e-01 -0.023600 8.48e-01
Selenoamino acid metabolism 115 6.65e-01 0.023400 8.55e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 7.71e-01 0.023300 9.09e-01
Ca2+ pathway 58 7.59e-01 0.023300 9.00e-01
O-linked glycosylation 85 7.11e-01 -0.023200 8.80e-01
Metabolism of lipids 642 3.16e-01 -0.023200 6.33e-01
RNA Polymerase I Promoter Escape 45 7.88e-01 0.023200 9.18e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 8.62e-01 0.023000 9.51e-01
Immune System 1841 1.03e-01 0.023000 3.78e-01
Innate Immune System 971 2.27e-01 0.022900 5.38e-01
Metabolism 1835 1.04e-01 -0.022900 3.82e-01
Complex III assembly 23 8.50e-01 -0.022700 9.47e-01
MITF-M-regulated melanocyte development 113 6.79e-01 0.022500 8.64e-01
Acyl chain remodelling of PE 20 8.62e-01 0.022500 9.51e-01
Trafficking of GluR2-containing AMPA receptors 11 8.98e-01 0.022400 9.64e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 8.41e-01 0.022300 9.44e-01
mTORC1-mediated signalling 24 8.50e-01 -0.022300 9.47e-01
Plasma lipoprotein remodeling 18 8.71e-01 -0.022100 9.55e-01
Mitotic G1 phase and G1/S transition 138 6.56e-01 -0.021900 8.52e-01
Regulation of innate immune responses to cytosolic DNA 14 8.88e-01 -0.021800 9.62e-01
Formation of a pool of free 40S subunits 100 7.12e-01 0.021300 8.80e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 6.90e-01 -0.021300 8.67e-01
RND1 GTPase cycle 37 8.23e-01 -0.021200 9.36e-01
Influenza Infection 154 6.50e-01 -0.021200 8.48e-01
VEGFR2 mediated vascular permeability 26 8.52e-01 -0.021200 9.47e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 8.58e-01 -0.021100 9.50e-01
Aerobic respiration and respiratory electron transport 245 5.70e-01 0.021100 8.16e-01
Regulation of PTEN mRNA translation 13 8.97e-01 -0.020600 9.64e-01
Reactions specific to the complex N-glycan synthesis pathway 7 9.25e-01 0.020500 9.77e-01
Cellular response to heat stress 94 7.32e-01 0.020500 8.89e-01
The canonical retinoid cycle in rods (twilight vision) 9 9.15e-01 -0.020500 9.71e-01
Regulation of HSF1-mediated heat shock response 79 7.55e-01 0.020300 8.97e-01
G-protein beta:gamma signalling 29 8.50e-01 0.020300 9.47e-01
MITF-M-dependent gene expression 83 7.51e-01 -0.020200 8.96e-01
Attachment and Entry 9694614 14 8.97e-01 -0.019900 9.64e-01
Citric acid cycle (TCA cycle) 34 8.41e-01 0.019800 9.44e-01
Pyroptosis 25 8.64e-01 -0.019800 9.51e-01
RNA Polymerase III Transcription Initiation 36 8.38e-01 0.019600 9.44e-01
RHO GTPases Activate NADPH Oxidases 21 8.78e-01 0.019400 9.59e-01
Nuclear Receptor transcription pathway 40 8.32e-01 -0.019400 9.40e-01
RA biosynthesis pathway 13 9.05e-01 -0.019100 9.66e-01
Establishment of Sister Chromatid Cohesion 11 9.13e-01 0.019100 9.70e-01
Regulation of NFE2L2 gene expression 8 9.26e-01 0.019000 9.77e-01
HCMV Infection 106 7.36e-01 -0.019000 8.89e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 7.91e-01 0.018900 9.19e-01
Mitochondrial protein import 63 7.97e-01 0.018800 9.23e-01
Metabolism of steroids 125 7.17e-01 -0.018800 8.82e-01
Hemostasis 562 4.49e-01 0.018700 7.35e-01
Activation of caspases through apoptosome-mediated cleavage 6 9.37e-01 0.018600 9.83e-01
Signaling by GPCR 442 5.06e-01 0.018400 7.78e-01
MECP2 regulates transcription factors 5 9.44e-01 -0.018200 9.84e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 9.39e-01 0.018200 9.83e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 8.44e-01 0.018200 9.44e-01
Formation of the Editosome 6 9.39e-01 -0.018000 9.83e-01
mRNA Editing: C to U Conversion 6 9.39e-01 -0.018000 9.83e-01
M Phase 346 5.65e-01 0.018000 8.13e-01
Cellular response to mitochondrial stress 9 9.26e-01 0.018000 9.77e-01
DNA Replication Pre-Initiation 103 7.53e-01 0.017900 8.96e-01
The activation of arylsulfatases 10 9.22e-01 -0.017800 9.75e-01
Ion homeostasis 42 8.44e-01 -0.017500 9.44e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.98e-01 0.017500 9.64e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 9.12e-01 -0.017000 9.70e-01
Sensory processing of sound 58 8.23e-01 -0.017000 9.36e-01
Downregulation of ERBB2 signaling 24 8.86e-01 0.016900 9.62e-01
SLBP independent Processing of Histone Pre-mRNAs 10 9.27e-01 -0.016600 9.78e-01
CD209 (DC-SIGN) signaling 20 8.98e-01 -0.016500 9.64e-01
Association of TriC/CCT with target proteins during biosynthesis 35 8.66e-01 -0.016500 9.52e-01
Transcriptional Regulation by TP53 346 6.03e-01 -0.016300 8.33e-01
Ion channel transport 141 7.39e-01 -0.016200 8.91e-01
Antimicrobial peptides 34 8.70e-01 0.016200 9.55e-01
Nicotinate metabolism 26 8.87e-01 0.016100 9.62e-01
Synthesis of bile acids and bile salts 27 8.86e-01 0.016000 9.62e-01
Eukaryotic Translation Elongation 93 7.90e-01 -0.016000 9.19e-01
Metabolism of steroid hormones 22 8.97e-01 0.015900 9.64e-01
Formation of TC-NER Pre-Incision Complex 51 8.44e-01 0.015900 9.44e-01
Diseases associated with N-glycosylation of proteins 20 9.04e-01 -0.015600 9.66e-01
COPII-mediated vesicle transport 67 8.27e-01 0.015500 9.38e-01
mRNA Editing 8 9.40e-01 -0.015300 9.83e-01
Signaling by the B Cell Receptor (BCR) 150 7.47e-01 0.015300 8.95e-01
Cell Cycle Checkpoints 246 6.84e-01 -0.015100 8.65e-01
GPCR downstream signalling 398 6.07e-01 0.015000 8.35e-01
NCAM signaling for neurite out-growth 48 8.58e-01 0.014900 9.50e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 8.97e-01 0.014700 9.64e-01
Transcriptional regulation of testis differentiation 5 9.55e-01 0.014600 9.90e-01
Integration of energy metabolism 88 8.16e-01 0.014400 9.33e-01
Adaptive Immune System 768 4.99e-01 0.014300 7.73e-01
MHC class II antigen presentation 113 7.96e-01 -0.014100 9.23e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 8.96e-01 -0.014000 9.64e-01
Gap junction degradation 11 9.37e-01 0.013800 9.83e-01
Signaling by FGFR2 in disease 33 8.91e-01 0.013800 9.64e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 9.10e-01 0.013700 9.69e-01
Surfactant metabolism 21 9.14e-01 0.013700 9.70e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 8.14e-01 0.013600 9.32e-01
Infectious disease 959 4.85e-01 0.013300 7.66e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 8.65e-01 0.013300 9.51e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 8.65e-01 0.013300 9.51e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 8.65e-01 0.013300 9.51e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 8.65e-01 0.013300 9.51e-01
Signaling by NOTCH1 in Cancer 55 8.65e-01 0.013300 9.51e-01
Thyroxine biosynthesis 5 9.59e-01 -0.013200 9.92e-01
Fc epsilon receptor (FCERI) signaling 179 7.65e-01 -0.012900 9.05e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 9.21e-01 -0.012700 9.75e-01
Trafficking of AMPA receptors 20 9.21e-01 -0.012700 9.75e-01
Lysosome Vesicle Biogenesis 32 9.03e-01 0.012500 9.65e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 8.45e-01 0.012300 9.44e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 8.45e-01 0.012300 9.44e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 8.45e-01 0.012300 9.44e-01
Death Receptor Signaling 145 8.00e-01 -0.012200 9.24e-01
tRNA modification in the mitochondrion 9 9.50e-01 -0.012200 9.88e-01
Adenylate cyclase inhibitory pathway 11 9.44e-01 0.012100 9.84e-01
Regulation of KIT signaling 15 9.35e-01 -0.012100 9.82e-01
Carboxyterminal post-translational modifications of tubulin 34 9.04e-01 -0.011900 9.66e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 9.16e-01 -0.011700 9.71e-01
Loss of Function of SMAD2/3 in Cancer 7 9.58e-01 -0.011500 9.92e-01
ABC transporters in lipid homeostasis 14 9.42e-01 -0.011200 9.84e-01
Post-translational protein modification 1243 5.21e-01 0.010800 7.90e-01
Activation of BH3-only proteins 30 9.20e-01 0.010600 9.75e-01
Cell death signalling via NRAGE, NRIF and NADE 69 8.79e-01 -0.010600 9.59e-01
Inflammasomes 21 9.34e-01 0.010400 9.82e-01
Glycerophospholipid biosynthesis 105 8.56e-01 0.010200 9.49e-01
RHOU GTPase cycle 40 9.11e-01 -0.010200 9.70e-01
Nuclear Events (kinase and transcription factor activation) 54 8.98e-01 0.010100 9.64e-01
2-LTR circle formation 7 9.63e-01 -0.010100 9.92e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 9.63e-01 0.010000 9.92e-01
RSV-host interactions 78 8.82e-01 0.009760 9.60e-01
Early Phase of HIV Life Cycle 14 9.50e-01 -0.009750 9.88e-01
Bile acid and bile salt metabolism 31 9.28e-01 0.009340 9.78e-01
RAC1 GTPase cycle 173 8.35e-01 -0.009180 9.42e-01
DNA Damage Recognition in GG-NER 38 9.24e-01 -0.009000 9.76e-01
Loss of Nlp from mitotic centrosomes 69 8.99e-01 -0.008840 9.64e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 8.99e-01 -0.008840 9.64e-01
Peptide chain elongation 88 8.86e-01 -0.008820 9.62e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 9.71e-01 0.008700 9.92e-01
LDL clearance 18 9.49e-01 0.008660 9.88e-01
Viral mRNA Translation 88 8.89e-01 0.008620 9.63e-01
EML4 and NUDC in mitotic spindle formation 107 8.80e-01 0.008470 9.59e-01
CDC42 GTPase cycle 141 8.63e-01 0.008390 9.51e-01
Interconversion of nucleotide di- and triphosphates 27 9.41e-01 0.008240 9.83e-01
Ovarian tumor domain proteases 37 9.31e-01 0.008170 9.80e-01
Factors involved in megakaryocyte development and platelet production 129 8.73e-01 -0.008150 9.57e-01
RHOD GTPase cycle 50 9.21e-01 -0.008070 9.75e-01
FOXO-mediated transcription of cell death genes 16 9.56e-01 -0.008010 9.90e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 9.55e-01 0.007940 9.90e-01
RHOB GTPase cycle 65 9.14e-01 -0.007770 9.70e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.52e-01 -0.007570 9.89e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.52e-01 -0.007570 9.89e-01
Signaling by ALK fusions and activated point mutants 89 9.02e-01 0.007550 9.65e-01
Signaling by ALK in cancer 89 9.02e-01 0.007550 9.65e-01
Selenocysteine synthesis 92 9.01e-01 -0.007530 9.65e-01
Neuronal System 276 8.40e-01 0.007080 9.44e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 9.69e-01 0.007020 9.92e-01
Defective EXT2 causes exostoses 2 10 9.69e-01 0.007020 9.92e-01
Regulation of CDH11 function 10 9.69e-01 0.007000 9.92e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 9.62e-01 -0.006900 9.92e-01
CRMPs in Sema3A signaling 13 9.66e-01 0.006760 9.92e-01
Eukaryotic Translation Termination 92 9.12e-01 0.006680 9.70e-01
Tight junction interactions 17 9.63e-01 -0.006580 9.92e-01
Protein lipoylation 10 9.71e-01 0.006550 9.92e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 9.76e-01 0.006520 9.92e-01
Viral Infection Pathways 776 7.58e-01 0.006490 8.99e-01
Regulation of insulin secretion 63 9.30e-01 0.006410 9.79e-01
SARS-CoV-2 modulates host translation machinery 49 9.39e-01 0.006300 9.83e-01
PKA activation in glucagon signalling 14 9.68e-01 -0.006240 9.92e-01
Assembly of collagen fibrils and other multimeric structures 44 9.44e-01 0.006070 9.84e-01
Regulation of PLK1 Activity at G2/M Transition 87 9.24e-01 0.005900 9.76e-01
Formation of RNA Pol II elongation complex 56 9.40e-01 0.005830 9.83e-01
RNA Polymerase II Transcription Elongation 56 9.40e-01 0.005830 9.83e-01
Oncogene Induced Senescence 33 9.55e-01 0.005700 9.90e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 9.59e-01 0.005670 9.92e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.69e-01 0.005030 9.92e-01
PI3K Cascade 31 9.62e-01 0.004980 9.92e-01
Metabolism of amino acids and derivatives 308 8.82e-01 0.004910 9.60e-01
Deadenylation-dependent mRNA decay 50 9.53e-01 -0.004860 9.89e-01
Cholesterol biosynthesis 26 9.66e-01 -0.004790 9.92e-01
PKA-mediated phosphorylation of CREB 17 9.73e-01 -0.004730 9.92e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 9.68e-01 0.004640 9.92e-01
Positive epigenetic regulation of rRNA expression 60 9.51e-01 -0.004610 9.89e-01
Activation of RAC1 11 9.79e-01 0.004570 9.93e-01
RND3 GTPase cycle 36 9.63e-01 -0.004500 9.92e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.77e-01 0.003800 9.92e-01
Retrograde transport at the Trans-Golgi-Network 49 9.65e-01 0.003660 9.92e-01
Signaling by FLT3 fusion proteins 18 9.79e-01 -0.003630 9.93e-01
Late Phase of HIV Life Cycle 131 9.43e-01 0.003630 9.84e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 9.85e-01 0.003290 9.96e-01
Transcription of the HIV genome 67 9.65e-01 0.003130 9.92e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.81e-01 0.003070 9.94e-01
p75 NTR receptor-mediated signalling 89 9.60e-01 -0.003050 9.92e-01
HIV Transcription Initiation 45 9.73e-01 0.002880 9.92e-01
RNA Polymerase II HIV Promoter Escape 45 9.73e-01 0.002880 9.92e-01
RNA Polymerase II Promoter Escape 45 9.73e-01 0.002880 9.92e-01
RNA Polymerase II Transcription Initiation 45 9.73e-01 0.002880 9.92e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 9.73e-01 0.002880 9.92e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 9.73e-01 0.002880 9.92e-01
SLC15A4:TASL-dependent IRF5 activation 6 9.90e-01 -0.002850 9.98e-01
Interleukin-15 signaling 14 9.86e-01 -0.002800 9.96e-01
RHOF GTPase cycle 39 9.77e-01 -0.002720 9.92e-01
Acyl chain remodeling of CL 5 9.92e-01 -0.002620 9.99e-01
Resolution of Sister Chromatid Cohesion 116 9.62e-01 0.002570 9.92e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 9.85e-01 0.002410 9.96e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 9.86e-01 -0.002240 9.96e-01
Neurodegenerative Diseases 21 9.86e-01 -0.002240 9.96e-01
HIV Life Cycle 144 9.67e-01 -0.002020 9.92e-01
Kinesins 51 9.80e-01 -0.002010 9.94e-01
RAC2 GTPase cycle 86 9.76e-01 0.001880 9.92e-01
Interferon gamma signaling 90 9.76e-01 -0.001850 9.92e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 9.91e-01 0.001700 9.98e-01
Fatty acyl-CoA biosynthesis 35 9.87e-01 0.001640 9.96e-01
G2/M Checkpoints 126 9.76e-01 -0.001570 9.92e-01
Cyclin D associated events in G1 47 9.85e-01 0.001570 9.96e-01
G1 Phase 47 9.85e-01 0.001570 9.96e-01
AKT phosphorylates targets in the cytosol 14 9.93e-01 0.001400 9.99e-01
Disease 1633 9.30e-01 0.001300 9.79e-01
Phospholipase C-mediated cascade; FGFR4 6 9.96e-01 0.001260 9.99e-01
TRIF-mediated programmed cell death 9 9.95e-01 0.001240 9.99e-01
Interleukin-6 signaling 11 9.95e-01 0.001030 9.99e-01
Platelet calcium homeostasis 22 9.94e-01 0.000976 9.99e-01
Signaling by ERBB2 TMD/JMD mutants 17 9.95e-01 0.000958 9.99e-01
Activation of Ca-permeable Kainate Receptor 9 9.97e-01 -0.000808 9.99e-01
Ionotropic activity of kainate receptors 9 9.97e-01 -0.000808 9.99e-01
RHOBTB3 ATPase cycle 10 9.97e-01 -0.000618 9.99e-01
RHOA GTPase cycle 139 9.90e-01 0.000603 9.98e-01
CLEC7A (Dectin-1) induces NFAT activation 11 9.97e-01 0.000546 9.99e-01
Metabolism of folate and pterines 16 9.97e-01 -0.000529 9.99e-01
SARS-CoV-2 Infection 267 9.91e-01 0.000402 9.98e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.99e-01 -0.000284 9.99e-01
Pyrimidine salvage 10 9.99e-01 0.000236 9.99e-01


Detailed Gene set reports



RUNX1 regulates transcription of genes involved in BCR signaling
set RUNX1 regulates transcription of genes involved in BCR signaling
setSize 6
pANOVA 0.001
s.dist 0.776
p.adjustANOVA 0.0258


Top enriched genes
Top 20 genes
GeneID Gene Rank
BLK 10173
ELF1 10056
ELF2 8659
PAX5 8525
RUNX1 8246
CBFB 4791

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All member genes
GeneID Gene Rank
BLK 10173
ELF1 10056
ELF2 8659
PAX5 8525
RUNX1 8246
CBFB 4791


CD163 mediating an anti-inflammatory response
set CD163 mediating an anti-inflammatory response
setSize 9
pANOVA 7.14e-05
s.dist 0.764
p.adjustANOVA 0.00518


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD163 10870
IL10 10463
ADAM17 10104
RHBDF2 9795
FURIN 8552
PLK2 7073
IL6 6500
MYH9 5965
MAPK14 5231

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All member genes
GeneID Gene Rank
CD163 10870
IL10 10463
ADAM17 10104
RHBDF2 9795
FURIN 8552
PLK2 7073
IL6 6500
MYH9 5965
MAPK14 5231


Formation of xylulose-5-phosphate
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.00686
s.dist -0.698
p.adjustANOVA 0.0833


Top enriched genes
Top 20 genes
GeneID Gene Rank
SORD -10694
XYLB -10640
CRYL1 -8975
AKR1A1 -6268
DCXR -2415

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All member genes
GeneID Gene Rank
SORD -10694
XYLB -10640
CRYL1 -8975
AKR1A1 -6268
DCXR -2415


Defective LFNG causes SCDO3
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0083
s.dist -0.682
p.adjustANOVA 0.0911


Top enriched genes
Top 20 genes
GeneID Gene Rank
LFNG -10840
NOTCH4 -9612
NOTCH2 -8816
NOTCH1 -8029
NOTCH3 -786

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All member genes
GeneID Gene Rank
LFNG -10840
NOTCH4 -9612
NOTCH2 -8816
NOTCH1 -8029
NOTCH3 -786


Fructose metabolism
set Fructose metabolism
setSize 7
pANOVA 0.00181
s.dist -0.681
p.adjustANOVA 0.0372


Top enriched genes
Top 20 genes
GeneID Gene Rank
SORD -10694
ALDH1A1 -10204
TKFC -8839
KHK -8768
AKR1B1 -8218
GLYCTK -5711
ALDOB -826

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All member genes
GeneID Gene Rank
SORD -10694
ALDH1A1 -10204
TKFC -8839
KHK -8768
AKR1B1 -8218
GLYCTK -5711
ALDOB -826


Formation of the ureteric bud
set Formation of the ureteric bud
setSize 5
pANOVA 0.0109
s.dist 0.658
p.adjustANOVA 0.107


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXC1 10828
WNT11 9845
GREM1 8772
RET 8717
ITGB1 -2613

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All member genes
GeneID Gene Rank
FOXC1 10828
WNT11 9845
GREM1 8772
RET 8717
ITGB1 -2613


NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
set NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
setSize 8
pANOVA 0.00131
s.dist -0.656
p.adjustANOVA 0.0294


Top enriched genes
Top 20 genes
GeneID Gene Rank
NR1H3 -10211
SREBF1 -10116
SCD -10023
RXRA -8822
FASN -6407
RXRB -6059
NRIP1 -5367
NR1H2 -1689

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All member genes
GeneID Gene Rank
NR1H3 -10211
SREBF1 -10116
SCD -10023
RXRA -8822
FASN -6407
RXRB -6059
NRIP1 -5367
NR1H2 -1689


LTC4-CYSLTR mediated IL4 production
set LTC4-CYSLTR mediated IL4 production
setSize 5
pANOVA 0.0123
s.dist -0.647
p.adjustANOVA 0.116


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYSLTR2 -11081
GGT5 -10416
CYSLTR1 -7246
DPEP2 -4289
GGT1 -3125

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All member genes
GeneID Gene Rank
CYSLTR2 -11081
GGT5 -10416
CYSLTR1 -7246
DPEP2 -4289
GGT1 -3125


Fructose catabolism
set Fructose catabolism
setSize 5
pANOVA 0.0175
s.dist -0.614
p.adjustANOVA 0.147


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALDH1A1 -10204
TKFC -8839
KHK -8768
GLYCTK -5711
ALDOB -826

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All member genes
GeneID Gene Rank
ALDH1A1 -10204
TKFC -8839
KHK -8768
GLYCTK -5711
ALDOB -826


Erythrocytes take up oxygen and release carbon dioxide
set Erythrocytes take up oxygen and release carbon dioxide
setSize 7
pANOVA 0.00585
s.dist 0.602
p.adjustANOVA 0.0763


Top enriched genes
Top 20 genes
GeneID Gene Rank
AQP1 8587
CA4 8075
SLC4A1 7566
CA1 6897
CA2 5818
HBB 4948
HBA1 3565

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All member genes
GeneID Gene Rank
AQP1 8587
CA4 8075
SLC4A1 7566
CA1 6897
CA2 5818
HBB 4948
HBA1 3565


MECP2 regulates transcription of neuronal ligands
set MECP2 regulates transcription of neuronal ligands
setSize 5
pANOVA 0.02
s.dist -0.601
p.adjustANOVA 0.156


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLL1 -8938
HDAC1 -7595
MECP2 -6982
SIN3A -5120
CREB1 -5008

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All member genes
GeneID Gene Rank
DLL1 -8938
HDAC1 -7595
MECP2 -6982
SIN3A -5120
CREB1 -5008


Defects in biotin (Btn) metabolism
set Defects in biotin (Btn) metabolism
setSize 8
pANOVA 0.00416
s.dist -0.585
p.adjustANOVA 0.0637


Top enriched genes
Top 20 genes
GeneID Gene Rank
BTD -10009
ACACA -9982
MCCC1 -9884
PC -9315
PCCA -8791
MCCC2 -7444
PCCB -2669
HLCS 5656

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All member genes
GeneID Gene Rank
BTD -10009
ACACA -9982
MCCC1 -9884
PC -9315
PCCA -8791
MCCC2 -7444
PCCB -2669
HLCS 5656


Alternative complement activation
set Alternative complement activation
setSize 5
pANOVA 0.0239
s.dist -0.583
p.adjustANOVA 0.172


Top enriched genes
Top 20 genes
GeneID Gene Rank
C3 -9745
GZMM -7312
CFB -6719
CFD -4668
CFP -4243

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All member genes
GeneID Gene Rank
C3 -9745
GZMM -7312
CFB -6719
CFD -4668
CFP -4243


APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
set APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
setSize 7
pANOVA 0.00976
s.dist -0.564
p.adjustANOVA 0.0998


Top enriched genes
Top 20 genes
GeneID Gene Rank
LIG3 -10358
OGG1 -9135
PNKP -9098
XRCC1 -7147
POLB -6080
NEIL2 -4951
NEIL1 2509

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All member genes
GeneID Gene Rank
LIG3 -10358
OGG1 -9135
PNKP -9098
XRCC1 -7147
POLB -6080
NEIL2 -4951
NEIL1 2509


Phenylalanine metabolism
set Phenylalanine metabolism
setSize 5
pANOVA 0.0307
s.dist -0.558
p.adjustANOVA 0.198


Top enriched genes
Top 20 genes
GeneID Gene Rank
ASRGL1 -11085
KYAT1 -9956
QDPR -8671
IL4I1 -6468
PCBD1 4891

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All member genes
GeneID Gene Rank
ASRGL1 -11085
KYAT1 -9956
QDPR -8671
IL4I1 -6468
PCBD1 4891


MET activates RAP1 and RAC1
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.0025
s.dist 0.552
p.adjustANOVA 0.0461


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF 10352
RAP1A 10000
GAB1 9180
RAP1B 7726
RAC1 7397
CRK 6129
GRB2 4635
DOCK7 3436
CRKL 1548
RAPGEF1 -923

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All member genes
GeneID Gene Rank
HGF 10352
RAP1A 10000
GAB1 9180
RAP1B 7726
RAC1 7397
CRK 6129
GRB2 4635
DOCK7 3436
CRKL 1548
RAPGEF1 -923


ATF6 (ATF6-alpha) activates chaperone genes
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.00266
s.dist 0.549
p.adjustANOVA 0.0479


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 10605
ATF4 9534
CALR 9525
HSP90B1 8843
XBP1 7887
NFYC 7669
ATF6 7373
NFYA 3512
DDIT3 3411
NFYB -9237

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All member genes
GeneID Gene Rank
HSPA5 10605
ATF4 9534
CALR 9525
HSP90B1 8843
XBP1 7887
NFYC 7669
ATF6 7373
NFYA 3512
DDIT3 3411
NFYB -9237


MET activates PI3K/AKT signaling
set MET activates PI3K/AKT signaling
setSize 5
pANOVA 0.0362
s.dist 0.541
p.adjustANOVA 0.217


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF 10352
GAB1 9180
PIK3R1 5492
GRB2 4635
PIK3CA -522

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All member genes
GeneID Gene Rank
HGF 10352
GAB1 9180
PIK3R1 5492
GRB2 4635
PIK3CA -522


Defective HLCS causes multiple carboxylase deficiency
set Defective HLCS causes multiple carboxylase deficiency
setSize 7
pANOVA 0.0133
s.dist -0.54
p.adjustANOVA 0.121


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACACA -9982
MCCC1 -9884
PC -9315
PCCA -8791
MCCC2 -7444
PCCB -2669
HLCS 5656

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All member genes
GeneID Gene Rank
ACACA -9982
MCCC1 -9884
PC -9315
PCCA -8791
MCCC2 -7444
PCCB -2669
HLCS 5656


Reversible hydration of carbon dioxide
set Reversible hydration of carbon dioxide
setSize 8
pANOVA 0.01
s.dist 0.526
p.adjustANOVA 0.101


Top enriched genes
Top 20 genes
GeneID Gene Rank
CA5B 9387
CA4 8075
CA14 7278
CA13 7233
CA1 6897
CA2 5818
CA6 2236
CA3 -1645

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All member genes
GeneID Gene Rank
CA5B 9387
CA4 8075
CA14 7278
CA13 7233
CA1 6897
CA2 5818
CA6 2236
CA3 -1645


Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
set Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
setSize 6
pANOVA 0.0257
s.dist 0.526
p.adjustANOVA 0.18


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP1B1 9685
CYP2C8 7573
CYP1A2 5549
CYP2U1 4672
CYP4F2 3570
CYP2C9 2909

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All member genes
GeneID Gene Rank
CYP1B1 9685
CYP2C8 7573
CYP1A2 5549
CYP2U1 4672
CYP4F2 3570
CYP2C9 2909


Propionyl-CoA catabolism
set Propionyl-CoA catabolism
setSize 5
pANOVA 0.0444
s.dist -0.519
p.adjustANOVA 0.243


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCEE -10641
PCCA -8791
MMAA -3968
MMUT -3076
PCCB -2669

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All member genes
GeneID Gene Rank
MCEE -10641
PCCA -8791
MMAA -3968
MMUT -3076
PCCB -2669


Synthesis of PG
set Synthesis of PG
setSize 8
pANOVA 0.0116
s.dist -0.515
p.adjustANOVA 0.111


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLD4 -11117
PLD3 -10178
PLD2 -8288
PLD6 -7282
DUSP23 -6549
PLD1 -2857
CDS2 -1769
PGS1 1763

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All member genes
GeneID Gene Rank
PLD4 -11117
PLD3 -10178
PLD2 -8288
PLD6 -7282
DUSP23 -6549
PLD1 -2857
CDS2 -1769
PGS1 1763


Negative regulation of TCF-dependent signaling by DVL-interacting proteins
set Negative regulation of TCF-dependent signaling by DVL-interacting proteins
setSize 5
pANOVA 0.0466
s.dist -0.514
p.adjustANOVA 0.25


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL2 -10519
DVL3 -5756
CCDC88C -5645
DVL1 -4410
CXXC4 -2533

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All member genes
GeneID Gene Rank
DVL2 -10519
DVL3 -5756
CCDC88C -5645
DVL1 -4410
CXXC4 -2533


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0466
s.dist -0.514
p.adjustANOVA 0.25


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 -9440
SUOX -9408
ETHE1 -8034
TST -3519
TSTD1 1543

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All member genes
GeneID Gene Rank
SLC25A10 -9440
SUOX -9408
ETHE1 -8034
TST -3519
TSTD1 1543


Defective binding of VWF variant to GPIb:IX:V
set Defective binding of VWF variant to GPIb:IX:V
setSize 7
pANOVA 0.019
s.dist 0.512
p.adjustANOVA 0.154


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL1A1 9601
GP9 7555
GP5 6423
COL1A2 5787
GP1BA 5145
VWF 3582
GP1BB 452

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All member genes
GeneID Gene Rank
COL1A1 9601
GP9 7555
GP5 6423
COL1A2 5787
GP1BA 5145
VWF 3582
GP1BB 452


Enhanced binding of GP1BA variant to VWF multimer:collagen
set Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize 7
pANOVA 0.019
s.dist 0.512
p.adjustANOVA 0.154


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL1A1 9601
GP9 7555
GP5 6423
COL1A2 5787
GP1BA 5145
VWF 3582
GP1BB 452

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All member genes
GeneID Gene Rank
COL1A1 9601
GP9 7555
GP5 6423
COL1A2 5787
GP1BA 5145
VWF 3582
GP1BB 452


PTK6 Regulates Cell Cycle
set PTK6 Regulates Cell Cycle
setSize 6
pANOVA 0.0344
s.dist -0.499
p.adjustANOVA 0.21


Top enriched genes
Top 20 genes
GeneID Gene Rank
CDK4 -10112
CCNE1 -9611
CDKN1B -8155
CCND1 -4767
PTK6 -2253
CDK2 1276

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All member genes
GeneID Gene Rank
CDK4 -10112
CCNE1 -9611
CDKN1B -8155
CCND1 -4767
PTK6 -2253
CDK2 1276


Activation of NOXA and translocation to mitochondria
set Activation of NOXA and translocation to mitochondria
setSize 5
pANOVA 0.0567
s.dist -0.492
p.adjustANOVA 0.275


Top enriched genes
Top 20 genes
GeneID Gene Rank
TP53 -10786
TFDP2 -9168
E2F1 -8526
PMAIP1 -6116
TFDP1 6932

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All member genes
GeneID Gene Rank
TP53 -10786
TFDP2 -9168
E2F1 -8526
PMAIP1 -6116
TFDP1 6932


Molybdenum cofactor biosynthesis
set Molybdenum cofactor biosynthesis
setSize 6
pANOVA 0.0385
s.dist -0.488
p.adjustANOVA 0.226


Top enriched genes
Top 20 genes
GeneID Gene Rank
MOCS3 -9488
NFS1 -8414
GPHN -6754
MOCS1 -4518
MOCOS -2449
MOCS2 -1290

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All member genes
GeneID Gene Rank
MOCS3 -9488
NFS1 -8414
GPHN -6754
MOCS1 -4518
MOCOS -2449
MOCS2 -1290


IFNG signaling activates MAPKs
set IFNG signaling activates MAPKs
setSize 8
pANOVA 0.0174
s.dist 0.486
p.adjustANOVA 0.147


Top enriched genes
Top 20 genes
GeneID Gene Rank
IFNGR1 10727
MAPK1 10285
IFNGR2 9878
JAK1 5391
IFNG 4513
JAK2 3619
MAPK3 643
RAF1 -3314

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All member genes
GeneID Gene Rank
IFNGR1 10727
MAPK1 10285
IFNGR2 9878
JAK1 5391
IFNG 4513
JAK2 3619
MAPK3 643
RAF1 -3314


Carnitine shuttle
set Carnitine shuttle
setSize 12
pANOVA 0.00365
s.dist -0.485
p.adjustANOVA 0.06


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACACA -9982
SLC22A5 -9084
RXRA -8822
SLC25A20 -8808
CPT2 -7959
MID1IP1 -7656
PPARD -6926
ACACB -4554
PRKAG2 -1931
CPT1A -1912
PRKAB2 771
CPT1B 1485

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All member genes
GeneID Gene Rank
ACACA -9982
SLC22A5 -9084
RXRA -8822
SLC25A20 -8808
CPT2 -7959
MID1IP1 -7656
PPARD -6926
ACACB -4554
PRKAG2 -1931
CPT1A -1912
PRKAB2 771
CPT1B 1485


Unwinding of DNA
set Unwinding of DNA
setSize 12
pANOVA 0.00373
s.dist -0.483
p.adjustANOVA 0.0601


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCM4 -10332
GINS3 -9856
GINS2 -9432
CDC45 -8580
MCM7 -8377
MCM3 -7885
MCM5 -7234
MCM6 -4380
MCM2 -2974
GINS4 -882
GINS1 -542
MCM8 5245

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All member genes
GeneID Gene Rank
MCM4 -10332
GINS3 -9856
GINS2 -9432
CDC45 -8580
MCM7 -8377
MCM3 -7885
MCM5 -7234
MCM6 -4380
MCM2 -2974
GINS4 -882
GINS1 -542
MCM8 5245


Type I hemidesmosome assembly
set Type I hemidesmosome assembly
setSize 8
pANOVA 0.0185
s.dist -0.481
p.adjustANOVA 0.153


Top enriched genes
Top 20 genes
GeneID Gene Rank
DST -11084
KRT5 -10887
ITGB4 -9660
CD151 -9486
LAMB3 -8106
COL17A1 -5295
PLEC 5467
ITGA6 5785

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All member genes
GeneID Gene Rank
DST -11084
KRT5 -10887
ITGB4 -9660
CD151 -9486
LAMB3 -8106
COL17A1 -5295
PLEC 5467
ITGA6 5785


Signal attenuation
set Signal attenuation
setSize 9
pANOVA 0.0125
s.dist 0.481
p.adjustANOVA 0.117


Top enriched genes
Top 20 genes
GeneID Gene Rank
GRB10 10864
INSR 10835
MAPK1 10285
IRS2 10087
GRB2 4635
MAPK3 643
IRS1 555
SOS1 53
SHC1 -1485

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All member genes
GeneID Gene Rank
GRB10 10864
INSR 10835
MAPK1 10285
IRS2 10087
GRB2 4635
MAPK3 643
IRS1 555
SOS1 53
SHC1 -1485


Creation of C4 and C2 activators
set Creation of C4 and C2 activators
setSize 71
pANOVA 3.38e-12
s.dist -0.477
p.adjustANOVA 3.26e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV3D-20 -10770
IGLV1-36 -10752
FCN1 -10713
IGLV3-21 -10673
IGLV3-25 -10568
IGHG1 -10556
IGLV5-45 -10530
IGLV6-57 -10522
IGLC2 -10312
IGLV1-47 -10218
IGLV1-51 -10180
IGLC1 -10146
IGLV3-1 -10097
IGKV2-28 -10092
IGLV2-8 -9976
IGLV2-14 -9970
IGKV1D-39 -9905
IGLV7-46 -9813
IGHG4 -9508
IGHV4-39 -9355

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All member genes
GeneID Gene Rank
IGKV3D-20 -10770
IGLV1-36 -10752
FCN1 -10713
IGLV3-21 -10673
IGLV3-25 -10568
IGHG1 -10556
IGLV5-45 -10530
IGLV6-57 -10522
IGLC2 -10312
IGLV1-47 -10218
IGLV1-51 -10180
IGLC1 -10146
IGLV3-1 -10097
IGKV2-28 -10092
IGLV2-8 -9976
IGLV2-14 -9970
IGKV1D-39 -9905
IGLV7-46 -9813
IGHG4 -9508
IGHV4-39 -9355
IGKV3-20 -8990
IGLV2-11 -8958
IGLV1-40 -8872
IGKV3-15 -8761
IGHV1-2 -8749
IGHV2-70 -8679
IGLV7-43 -8665
IGHV4-34 -8650
IGLV3-27 -8499
C1QC -8335
IGLC3 -7934
IGLV8-61 -7916
IGHV4-59 -7534
MASP2 -7400
IGLV2-23 -7331
IGHV3-33 -7205
IGKC -6950
IGHV3-30 -6897
C1S -6299
IGKV4-1 -6109
IGKV1-5 -6083
C1QA -5807
IGKV1-33 -5586
IGLV3-12 -5384
IGHV1-46 -5328
IGHG3 -5227
IGHV3-7 -5041
IGKV1-12 -4886
IGLV3-19 -4647
IGHV3-11 -4375
IGHG2 -3704
IGLC7 -3483
IGHV3-13 -3312
IGLV1-44 -3133
IGHV1-69 -2333
IGHV2-5 -1006
IGKV2-29 -637
IGKV1-17 -405
IGHV3-23 100
IGKV2-30 211
IGKV2D-28 1647
C1R 1856
IGLV4-60 2003
IGKV1-16 2267
IGHV3-53 4425
C1QB 4711
IGHV3-48 5006
IGLV10-54 6921
IGKV3-11 7201
IGLV4-69 7562
IGLV2-18 9560


Initial triggering of complement
set Initial triggering of complement
setSize 79
pANOVA 3.69e-13
s.dist -0.473
p.adjustANOVA 7.13e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV3D-20 -10770
IGLV1-36 -10752
FCN1 -10713
IGLV3-21 -10673
IGLV3-25 -10568
IGHG1 -10556
IGLV5-45 -10530
IGLV6-57 -10522
IGLC2 -10312
IGLV1-47 -10218
IGLV1-51 -10180
IGLC1 -10146
IGLV3-1 -10097
IGKV2-28 -10092
IGLV2-8 -9976
IGLV2-14 -9970
IGKV1D-39 -9905
IGLV7-46 -9813
C3 -9745
IGHG4 -9508

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All member genes
GeneID Gene Rank
IGKV3D-20 -10770
IGLV1-36 -10752
FCN1 -10713
IGLV3-21 -10673
IGLV3-25 -10568
IGHG1 -10556
IGLV5-45 -10530
IGLV6-57 -10522
IGLC2 -10312
IGLV1-47 -10218
IGLV1-51 -10180
IGLC1 -10146
IGLV3-1 -10097
IGKV2-28 -10092
IGLV2-8 -9976
IGLV2-14 -9970
IGKV1D-39 -9905
IGLV7-46 -9813
C3 -9745
IGHG4 -9508
IGHV4-39 -9355
IGKV3-20 -8990
IGLV2-11 -8958
IGLV1-40 -8872
IGKV3-15 -8761
IGHV1-2 -8749
IGHV2-70 -8679
IGLV7-43 -8665
IGHV4-34 -8650
IGLV3-27 -8499
C1QC -8335
IGLC3 -7934
IGLV8-61 -7916
IGHV4-59 -7534
MASP2 -7400
IGLV2-23 -7331
GZMM -7312
IGHV3-33 -7205
IGKC -6950
IGHV3-30 -6897
CFB -6719
C4A -6387
C1S -6299
IGKV4-1 -6109
IGKV1-5 -6083
C1QA -5807
IGKV1-33 -5586
IGLV3-12 -5384
IGHV1-46 -5328
IGHG3 -5227
IGHV3-7 -5041
IGKV1-12 -4886
CFD -4668
IGLV3-19 -4647
IGHV3-11 -4375
CFP -4243
IGHG2 -3704
IGLC7 -3483
C2 -3379
IGHV3-13 -3312
IGLV1-44 -3133
IGHV1-69 -2333
IGHV2-5 -1006
IGKV2-29 -637
IGKV1-17 -405
IGHV3-23 100
IGKV2-30 211
IGKV2D-28 1647
C1R 1856
IGLV4-60 2003
IGKV1-16 2267
C4B 3997
IGHV3-53 4425
C1QB 4711
IGHV3-48 5006
IGLV10-54 6921
IGKV3-11 7201
IGLV4-69 7562
IGLV2-18 9560


Translocation of ZAP-70 to Immunological synapse
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 6.15e-05
s.dist -0.472
p.adjustANOVA 0.00475


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD4 -11039
HLA-DPA1 -10946
TRAV29DV5 -10861
HLA-DRA -10847
TRAV19 -10510
TRBV7-9 -10330
HLA-DPB1 -10224
TRAC -10059
HLA-DRB1 -9414
HLA-DQA2 -9024
HLA-DQB2 -7619
TRAV8-4 -7341
HLA-DQA1 -6245
LCK -6178
HLA-DRB5 -6099
ZAP70 -5905
TRBC1 -3349
TRBV12-3 -2794
CD247 -2547
PTPN22 1116

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD4 -11039
HLA-DPA1 -10946
TRAV29DV5 -10861
HLA-DRA -10847
TRAV19 -10510
TRBV7-9 -10330
HLA-DPB1 -10224
TRAC -10059
HLA-DRB1 -9414
HLA-DQA2 -9024
HLA-DQB2 -7619
TRAV8-4 -7341
HLA-DQA1 -6245
LCK -6178
HLA-DRB5 -6099
ZAP70 -5905
TRBC1 -3349
TRBV12-3 -2794
CD247 -2547
PTPN22 1116
HLA-DQB1 3452
CD3E 4238
CD3D 5605
CD3G 9435


Estrogen-stimulated signaling through PRKCZ
set Estrogen-stimulated signaling through PRKCZ
setSize 6
pANOVA 0.0468
s.dist 0.469
p.adjustANOVA 0.25


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 10285
PDPK1 8969
NRAS 6803
KRAS 4472
PRKCZ 3211
HRAS -3537

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 10285
PDPK1 8969
NRAS 6803
KRAS 4472
PRKCZ 3211
HRAS -3537


Classical antibody-mediated complement activation
set Classical antibody-mediated complement activation
setSize 69
pANOVA 1.8e-11
s.dist -0.468
p.adjustANOVA 1.16e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV3D-20 -10770
IGLV1-36 -10752
IGLV3-21 -10673
IGLV3-25 -10568
IGHG1 -10556
IGLV5-45 -10530
IGLV6-57 -10522
IGLC2 -10312
IGLV1-47 -10218
IGLV1-51 -10180
IGLC1 -10146
IGLV3-1 -10097
IGKV2-28 -10092
IGLV2-8 -9976
IGLV2-14 -9970
IGKV1D-39 -9905
IGLV7-46 -9813
IGHG4 -9508
IGHV4-39 -9355
IGKV3-20 -8990

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3D-20 -10770
IGLV1-36 -10752
IGLV3-21 -10673
IGLV3-25 -10568
IGHG1 -10556
IGLV5-45 -10530
IGLV6-57 -10522
IGLC2 -10312
IGLV1-47 -10218
IGLV1-51 -10180
IGLC1 -10146
IGLV3-1 -10097
IGKV2-28 -10092
IGLV2-8 -9976
IGLV2-14 -9970
IGKV1D-39 -9905
IGLV7-46 -9813
IGHG4 -9508
IGHV4-39 -9355
IGKV3-20 -8990
IGLV2-11 -8958
IGLV1-40 -8872
IGKV3-15 -8761
IGHV1-2 -8749
IGHV2-70 -8679
IGLV7-43 -8665
IGHV4-34 -8650
IGLV3-27 -8499
C1QC -8335
IGLC3 -7934
IGLV8-61 -7916
IGHV4-59 -7534
IGLV2-23 -7331
IGHV3-33 -7205
IGKC -6950
IGHV3-30 -6897
C1S -6299
IGKV4-1 -6109
IGKV1-5 -6083
C1QA -5807
IGKV1-33 -5586
IGLV3-12 -5384
IGHV1-46 -5328
IGHG3 -5227
IGHV3-7 -5041
IGKV1-12 -4886
IGLV3-19 -4647
IGHV3-11 -4375
IGHG2 -3704
IGLC7 -3483
IGHV3-13 -3312
IGLV1-44 -3133
IGHV1-69 -2333
IGHV2-5 -1006
IGKV2-29 -637
IGKV1-17 -405
IGHV3-23 100
IGKV2-30 211
IGKV2D-28 1647
C1R 1856
IGLV4-60 2003
IGKV1-16 2267
IGHV3-53 4425
C1QB 4711
IGHV3-48 5006
IGLV10-54 6921
IGKV3-11 7201
IGLV4-69 7562
IGLV2-18 9560


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.0237
s.dist -0.462
p.adjustANOVA 0.172


Top enriched genes
Top 20 genes
GeneID Gene Rank
PARG -9767
FEN1 -8026
PARP2 -7553
POLB -6080
LIG1 -4935
APEX1 -4025
ADPRS -2757
PARP1 1551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARG -9767
FEN1 -8026
PARP2 -7553
POLB -6080
LIG1 -4935
APEX1 -4025
ADPRS -2757
PARP1 1551


Diseases of Base Excision Repair
set Diseases of Base Excision Repair
setSize 5
pANOVA 0.0749
s.dist -0.46
p.adjustANOVA 0.321


Top enriched genes
Top 20 genes
GeneID Gene Rank
OGG1 -9135
MUTYH -8662
NTHL1 -5827
NEIL3 -4777
NEIL1 2509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OGG1 -9135
MUTYH -8662
NTHL1 -5827
NEIL3 -4777
NEIL1 2509


YAP1- and WWTR1 (TAZ)-stimulated gene expression
set YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize 7
pANOVA 0.0352
s.dist 0.46
p.adjustANOVA 0.213


Top enriched genes
Top 20 genes
GeneID Gene Rank
HIPK2 9894
WWTR1 9360
TEAD2 7617
KAT2B 5328
HIPK1 2246
RUNX2 1906
NPPA -1823

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIPK2 9894
WWTR1 9360
TEAD2 7617
KAT2B 5328
HIPK1 2246
RUNX2 1906
NPPA -1823


Biotin transport and metabolism
set Biotin transport and metabolism
setSize 11
pANOVA 0.00843
s.dist -0.459
p.adjustANOVA 0.092


Top enriched genes
Top 20 genes
GeneID Gene Rank
BTD -10009
ACACA -9982
MCCC1 -9884
PC -9315
PCCA -8791
MCCC2 -7444
ACACB -4554
PCCB -2669
PDZD11 -2015
SLC5A6 2202
HLCS 5656

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BTD -10009
ACACA -9982
MCCC1 -9884
PC -9315
PCCA -8791
MCCC2 -7444
ACACB -4554
PCCB -2669
PDZD11 -2015
SLC5A6 2202
HLCS 5656


Formation of the active cofactor, UDP-glucuronate
set Formation of the active cofactor, UDP-glucuronate
setSize 5
pANOVA 0.0778
s.dist 0.455
p.adjustANOVA 0.327


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC35D2 9916
UGP2 9578
UGDH 8692
SLC35D1 1652
UXS1 -5402

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC35D2 9916
UGP2 9578
UGDH 8692
SLC35D1 1652
UXS1 -5402


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.0375
s.dist 0.454
p.adjustANOVA 0.222


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLR2 10702
UBC 9892
B2M 5297
UBB 3507
MRC1 2766
RPS27A 2576
UBA52 -642

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 10702
UBC 9892
B2M 5297
UBB 3507
MRC1 2766
RPS27A 2576
UBA52 -642


Phosphorylation of Emi1
set Phosphorylation of Emi1
setSize 6
pANOVA 0.0547
s.dist -0.453
p.adjustANOVA 0.267


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLK1 -10105
CDC20 -7925
CDK1 -7504
FZR1 -6253
FBXO5 -1100
CCNB1 2284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLK1 -10105
CDC20 -7925
CDK1 -7504
FZR1 -6253
FBXO5 -1100
CCNB1 2284


Erythrocytes take up carbon dioxide and release oxygen
set Erythrocytes take up carbon dioxide and release oxygen
setSize 11
pANOVA 0.00931
s.dist 0.453
p.adjustANOVA 0.0972


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYB5R2 10638
AQP1 8587
CYB5R4 8095
CA4 8075
SLC4A1 7566
CA1 6897
CA2 5818
HBB 4948
HBA1 3565
CYB5R1 -768
CYB5RL -9992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYB5R2 10638
AQP1 8587
CYB5R4 8095
CA4 8075
SLC4A1 7566
CA1 6897
CA2 5818
HBB 4948
HBA1 3565
CYB5R1 -768
CYB5RL -9992


O2/CO2 exchange in erythrocytes
set O2/CO2 exchange in erythrocytes
setSize 11
pANOVA 0.00931
s.dist 0.453
p.adjustANOVA 0.0972


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYB5R2 10638
AQP1 8587
CYB5R4 8095
CA4 8075
SLC4A1 7566
CA1 6897
CA2 5818
HBB 4948
HBA1 3565
CYB5R1 -768
CYB5RL -9992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYB5R2 10638
AQP1 8587
CYB5R4 8095
CA4 8075
SLC4A1 7566
CA1 6897
CA2 5818
HBB 4948
HBA1 3565
CYB5R1 -768
CYB5RL -9992


Organic anion transporters
set Organic anion transporters
setSize 7
pANOVA 0.0388
s.dist -0.451
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 -9440
SLC25A11 -8642
SLC5A5 -7657
SLC25A22 -7187
SLC25A1 -6614
SLC17A5 -3015
SLC17A7 6998

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 -9440
SLC25A11 -8642
SLC5A5 -7657
SLC25A22 -7187
SLC25A1 -6614
SLC17A5 -3015
SLC17A7 6998


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.ATF6 (ATF6-alpha) activates chaperone genes`
## [1] "HSPA5"
## 
## [[1]]$`UP genesets.AUF1 (hnRNP D0) binds and destabilizes mRNA`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Activation of NF-kappaB in B cells`
## [1] "NFKBIA" "PSMA6"  "UBC"   
## 
## [[1]]$`UP genesets.CD163 mediating an anti-inflammatory response`
## [1] "ADAM17" "CD163"  "IL10"   "RHBDF2"
## 
## [[1]]$`UP genesets.Degradation of GLI1 by the proteasome`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Degradation of GLI2 by the proteasome`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Expression and translocation of olfactory receptors`
## [1] "OR10A6" "OR10G3" "OR14J1" "OR2H2"  "OR2M3"  "OR4D9" 
## 
## [[1]]$`UP genesets.GLI3 is processed to GLI3R by the proteasome`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Hedgehog ligand biogenesis`
## [1] "ADAM17" "PSMA6"  "UBC"   
## 
## [[1]]$`UP genesets.Hh mutants abrogate ligand secretion`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Hh mutants are degraded by ERAD`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.MET activates RAP1 and RAC1`
## [1] "HGF"   "RAP1A"
## 
## [[1]]$`UP genesets.Mitochondrial RNA degradation`
## [1] "SUPV3L1"
## 
## [[1]]$`UP genesets.Olfactory Signaling Pathway`
## [1] "CNGB1"  "OR10A6" "OR10G3" "OR14J1" "OR2H2"  "OR2M3"  "OR4D9" 
## 
## [[1]]$`UP genesets.PINK1-PRKN Mediated Mitophagy`
## [1] "MAP1LC3B" "UBC"     
## 
## [[1]]$`UP genesets.RUNX1 regulates transcription of genes involved in BCR signaling`
## [1] "BLK"  "ELF1"
## 
## [[1]]$`UP genesets.Regulation of Apoptosis`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Regulation of activated PAK-2p34 by proteasome mediated degradation`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`UP genesets.Vif-mediated degradation of APOBEC3G`
## [1] "PSMA6" "UBC"  
## 
## [[1]]$`DOWN genesets.CD22 mediated BCR regulation`
##  [1] "CD22"      "CD79A"     "CD79B"     "IGHD"      "IGHM"      "IGHV1-2"  
##  [7] "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13" 
## [13] "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"  
## [19] "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16" 
## [25] "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29" 
## [31] "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20"
## [37] "IGKV4-1"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-40" 
## [43] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-23" 
## [49] "IGLV2-8"   "IGLV3-1"   "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27" 
## [55] "IGLV6-57"  "IGLV7-43"  "LYN"       "PTPN6"    
## 
## [[1]]$`DOWN genesets.Classical antibody-mediated complement activation`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "IGHG1"    
##  [7] "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46"  "IGHV1-69" 
## [13] "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30" 
## [19] "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39" 
## [25] "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33" 
## [31] "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28"
## [37] "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGLC1"    
## [43] "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-36"  "IGLV1-40"  "IGLV1-44" 
## [49] "IGLV1-47"  "IGLV1-51"  "IGLV10-54" "IGLV2-11"  "IGLV2-14"  "IGLV2-18" 
## [55] "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21" 
## [61] "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57" 
## [67] "IGLV7-43"  "IGLV7-46"  "IGLV8-61" 
## 
## [[1]]$`DOWN genesets.Complement cascade`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "C2"       
##  [7] "C3"        "C4A"       "C4B"       "C4BPA"     "C4BPB"     "C5"       
## [13] "C5AR1"     "C5AR2"     "CD19"      "CD46"      "CD55"      "CD59"     
## [19] "CD81"      "CFB"       "CFD"       "CFP"       "CLU"       "CPN2"     
## [25] "CR1"       "CR2"       "ELANE"     "FCN1"      "GZMM"      "IGHG1"    
## [31] "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46"  "IGHV1-69" 
## [37] "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30" 
## [43] "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39" 
## [49] "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33" 
## [55] "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28"
## [61] "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGLC1"    
## [67] "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-36"  "IGLV1-40"  "IGLV1-44" 
## [73] "IGLV1-47"  "IGLV1-51"  "IGLV10-54" "IGLV2-11"  "IGLV2-14"  "IGLV2-18" 
## [79] "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21" 
## [85] "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57" 
## [91] "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "MASP2"     "PROS1"     "SERPING1" 
## [97] "VTN"      
## 
## [[1]]$`DOWN genesets.Creation of C4 and C2 activators`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "FCN1"     
##  [7] "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46" 
## [13] "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23" 
## [19] "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34" 
## [25] "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17" 
## [31] "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30" 
## [37] "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"  
## [43] "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-36"  "IGLV1-40" 
## [49] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV10-54" "IGLV2-11"  "IGLV2-14" 
## [55] "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19" 
## [61] "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45" 
## [67] "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "MASP2"    
## 
## [[1]]$`DOWN genesets.DNA strand elongation`
##  [1] "CDC45" "DNA2"  "FEN1"  "GINS1" "GINS2" "GINS3" "GINS4" "LIG1"  "MCM2" 
## [10] "MCM3"  "MCM4"  "MCM5"  "MCM6"  "MCM7"  "MCM8"  "PCNA"  "POLA1" "POLA2"
## [19] "POLD1" "POLD2" "POLD3" "POLD4" "PRIM1" "PRIM2" "RFC1"  "RFC2"  "RFC3" 
## [28] "RFC4"  "RFC5"  "RPA1"  "RPA2"  "RPA3" 
## 
## [[1]]$`DOWN genesets.FCGR activation`
##  [1] "CD247"     "CD3G"      "FCGR1A"    "FCGR2A"    "FCGR3A"    "FGR"      
##  [7] "HCK"       "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"  
## [13] "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13" 
## [19] "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"  
## [25] "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16" 
## [31] "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29" 
## [37] "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20"
## [43] "IGKV4-1"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-36" 
## [49] "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV10-54" "IGLV2-11" 
## [55] "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12" 
## [61] "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69" 
## [67] "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "LYN"      
## [73] "SRC"       "SYK"       "YES1"     
## 
## [[1]]$`DOWN genesets.Fructose metabolism`
## [1] "AKR1B1"  "ALDH1A1" "ALDOB"   "GLYCTK"  "KHK"     "SORD"    "TKFC"   
## 
## [[1]]$`DOWN genesets.G1/S-Specific Transcription`
##  [1] "CCNE1"  "CDC25A" "CDC45"  "CDC6"   "CDK1"   "CDT1"   "DHFR"   "E2F1"  
##  [9] "E2F4"   "E2F5"   "E2F6"   "FBXO5"  "HDAC1"  "LIN37"  "LIN52"  "LIN54" 
## [17] "LIN9"   "ORC1"   "PCNA"   "POLA1"  "RBBP4"  "RBL1"   "RBL2"   "RRM2"  
## [25] "TFDP1"  "TFDP2"  "TK1"    "TYMS"  
## 
## [[1]]$`DOWN genesets.Initial triggering of complement`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "C2"       
##  [7] "C3"        "C4A"       "C4B"       "CFB"       "CFD"       "CFP"      
## [13] "FCN1"      "GZMM"      "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"    
## [19] "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11" 
## [25] "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53" 
## [31] "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12" 
## [37] "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28" 
## [43] "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20" 
## [49] "IGKV3D-20" "IGKV4-1"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"    
## [55] "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV10-54"
## [61] "IGLV2-11"  "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"  
## [67] "IGLV3-12"  "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60" 
## [73] "IGLV4-69"  "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61" 
## [79] "MASP2"    
## 
## [[1]]$`DOWN genesets.NR1H2 & NR1H3 regulate gene expression linked to lipogenesis`
## [1] "FASN"   "NR1H2"  "NR1H3"  "NRIP1"  "RXRA"   "RXRB"   "SCD"    "SREBF1"
## 
## [[1]]$`DOWN genesets.NR1H2 and NR1H3-mediated signaling`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOD"    "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "FASN"   
## [15] "GPS2"    "HDAC3"   "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"  
## [22] "MYLIP"   "NCOA1"   "NCOR1"   "NCOR2"   "NR1H2"   "NR1H3"   "NRIP1"  
## [29] "PLIN1"   "PLTP"    "RXRA"    "RXRB"    "SCD"     "SREBF1"  "TBL1X"  
## [36] "TBL1XR1" "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOD"    "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "GPS2"   
## [15] "HDAC3"   "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"   "NCOA1"  
## [22] "NCOR1"   "NCOR2"   "NR1H2"   "NR1H3"   "PLTP"    "RXRA"    "RXRB"   
## [29] "TBL1X"   "TBL1XR1" "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.PD-1 signaling`
##  [1] "CD247"     "CD274"     "CD3D"      "CD3E"      "CD3G"      "CD4"      
##  [7] "CSK"       "HLA-DPA1"  "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1" 
## [13] "HLA-DQB2"  "HLA-DRA"   "HLA-DRB1"  "HLA-DRB5"  "LCK"       "PDCD1"    
## [19] "PDCD1LG2"  "PTPN11"    "PTPN6"     "TRAC"      "TRAV19"    "TRAV29DV5"
## [25] "TRAV8-4"   "TRBC1"     "TRBV12-3"  "TRBV7-9"  
## 
## [[1]]$`DOWN genesets.Phosphorylation of CD3 and TCR zeta chains`
##  [1] "CD247"     "CD3D"      "CD3E"      "CD3G"      "CD4"       "CSK"      
##  [7] "HLA-DPA1"  "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1"  "HLA-DQB2" 
## [13] "HLA-DRA"   "HLA-DRB1"  "HLA-DRB5"  "LCK"       "PTPN22"    "PTPRC"    
## [19] "PTPRJ"     "TRAC"      "TRAV19"    "TRAV29DV5" "TRAV8-4"   "TRBC1"    
## [25] "TRBV12-3"  "TRBV7-9"  
## 
## [[1]]$`DOWN genesets.Regulation of Complement cascade`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "C2"       
##  [7] "C3"        "C4A"       "C4B"       "C4BPA"     "C4BPB"     "C5"       
## [13] "C5AR1"     "C5AR2"     "CD19"      "CD46"      "CD55"      "CD59"     
## [19] "CD81"      "CFB"       "CFP"       "CLU"       "CPN2"      "CR1"      
## [25] "CR2"       "ELANE"     "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"    
## [31] "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11" 
## [37] "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53" 
## [43] "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12" 
## [49] "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28" 
## [55] "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20" 
## [61] "IGKV3D-20" "IGKV4-1"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"    
## [67] "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV10-54"
## [73] "IGLV2-11"  "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"  
## [79] "IGLV3-12"  "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60" 
## [85] "IGLV4-69"  "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61" 
## [91] "PROS1"     "SERPING1"  "VTN"      
## 
## [[1]]$`DOWN genesets.Resolution of Abasic Sites (AP sites)`
##  [1] "ADPRS" "APEX1" "FEN1"  "LIG1"  "LIG3"  "MBD4"  "MPG"   "MUTYH" "NEIL1"
## [10] "NEIL2" "NTHL1" "OGG1"  "PARG"  "PARP1" "PARP2" "PCNA"  "PNKP"  "POLB" 
## [19] "POLD1" "POLD2" "POLD3" "POLD4" "POLE"  "POLE2" "POLE3" "POLE4" "RFC1" 
## [28] "RFC2"  "RFC3"  "RFC4"  "RFC5"  "RPA1"  "RPA2"  "RPA3"  "SMUG1" "TDG"  
## [37] "UNG"   "XRCC1"
## 
## [[1]]$`DOWN genesets.Role of LAT2/NTAL/LAB on calcium mobilization`
##  [1] "FCER1A"    "FCER1G"    "GAB2"      "GRB2"      "IGHE"      "IGHV1-2"  
##  [7] "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13" 
## [13] "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"  
## [19] "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16" 
## [25] "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29" 
## [31] "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20"
## [37] "IGKV4-1"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-36" 
## [43] "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV10-54" "IGLV2-11" 
## [49] "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12" 
## [55] "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69" 
## [61] "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "LAT2"     
## [67] "LYN"       "MS4A2"     "PDPK1"     "PIK3CA"    "PIK3CB"    "PIK3R1"   
## [73] "PIK3R2"    "SHC1"      "SOS1"      "SYK"      
## 
## [[1]]$`DOWN genesets.Role of phospholipids in phagocytosis`
##  [1] "AHCYL1"    "CD247"     "CD3G"      "FCGR1A"    "FCGR2A"    "FCGR3A"   
##  [7] "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46" 
## [13] "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23" 
## [19] "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34" 
## [25] "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17" 
## [31] "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30" 
## [37] "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"  
## [43] "IGLC1"     "IGLC2"     "IGLC3"     "IGLC7"     "IGLV1-36"  "IGLV1-40" 
## [49] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV10-54" "IGLV2-11"  "IGLV2-14" 
## [55] "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19" 
## [61] "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45" 
## [67] "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "ITPR1"     "ITPR2"    
## [73] "ITPR3"     "PIK3CA"    "PIK3CB"    "PIK3R1"    "PIK3R2"    "PLA2G6"   
## [79] "PLCG1"     "PLCG2"     "PLD1"      "PLD2"      "PLD3"      "PLD4"     
## [85] "PLPP5"     "PRKCD"     "SYK"      
## 
## [[1]]$`DOWN genesets.Scavenging of heme from plasma`
##  [1] "APOL1"     "HBA1"      "HBB"       "HP"        "HPX"       "IGHA1"    
##  [7] "IGHA2"     "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70" 
## [13] "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48" 
## [19] "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"     
## [25] "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39"
## [31] "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15" 
## [37] "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGLC1"     "IGLC2"     "IGLC3"    
## [43] "IGLC7"     "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51" 
## [49] "IGLV10-54" "IGLV2-11"  "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"  
## [55] "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27" 
## [61] "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46" 
## [67] "IGLV8-61"  "JCHAIN"    "LRP1"     
## 
## [[1]]$`DOWN genesets.Translocation of ZAP-70 to Immunological synapse`
##  [1] "CD247"     "CD3D"      "CD3E"      "CD3G"      "CD4"       "HLA-DPA1" 
##  [7] "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1"  "HLA-DQB2"  "HLA-DRA"  
## [13] "HLA-DRB1"  "HLA-DRB5"  "LCK"       "PTPN22"    "TRAC"      "TRAV19"   
## [19] "TRAV29DV5" "TRAV8-4"   "TRBC1"     "TRBV12-3"  "TRBV7-9"   "ZAP70"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report