date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.6736967
A1BG -0.0624195
A1BG-AS1 -0.8820418
A1CF 1.0363139
A2M 1.4968030
A2M-AS1 2.1809387

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21253
duplicated_genes_present 0
num_profile_genes_in_sets 8700
num_profile_genes_not_in_sets 12553

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1198
num_genesets_included 1527

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
CD22 mediated BCR regulation 58 1.07e-26 -0.811 4.12e-24
Phosphorylation of Emi1 6 9.14e-04 -0.782 1.49e-02
Scavenging of heme from plasma 70 2.38e-29 -0.776 2.29e-26
FCGR activation 76 2.90e-31 -0.770 5.56e-28
Classical antibody-mediated complement activation 69 2.86e-27 -0.752 1.83e-24
G2/M DNA replication checkpoint 5 3.64e-03 -0.751 4.27e-02
Type I hemidesmosome assembly 8 3.99e-04 -0.723 7.59e-03
Creation of C4 and C2 activators 71 1.08e-25 -0.718 2.31e-23
Role of LAT2/NTAL/LAB on calcium mobilization 77 2.71e-25 -0.684 5.21e-23
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.49e-03 -0.670 8.35e-02
Unwinding of DNA 12 6.07e-05 -0.668 1.53e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 2.31e-03 -0.665 3.02e-02
Initial triggering of complement 79 7.12e-23 -0.640 7.60e-21
FCERI mediated Ca+2 mobilization 92 3.01e-25 -0.625 5.26e-23
FCGR3A-mediated IL10 synthesis 99 7.03e-27 -0.624 3.38e-24
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 9.00e-23 -0.623 9.10e-21
Role of phospholipids in phagocytosis 88 5.73e-24 -0.622 6.88e-22
Maturation of protein 3a 9683673 9 2.06e-03 -0.593 2.80e-02
Maturation of protein 3a 9694719 9 2.06e-03 -0.593 2.80e-02
Interleukin-21 signaling 9 2.08e-03 -0.593 2.81e-02
Binding and Uptake of Ligands by Scavenger Receptors 90 3.80e-22 -0.590 3.65e-20
PI3K events in ERBB4 signaling 6 1.45e-02 0.576 1.17e-01
Common Pathway of Fibrin Clot Formation 13 3.27e-04 -0.575 6.76e-03
Neurotransmitter clearance 6 1.65e-02 0.565 1.27e-01
Activation of NOXA and translocation to mitochondria 5 2.93e-02 -0.563 1.79e-01
Protein repair 6 1.71e-02 -0.562 1.29e-01
FCERI mediated MAPK activation 93 1.47e-20 -0.557 1.28e-18
Synthesis of Ketone Bodies 6 1.82e-02 -0.557 1.34e-01
Regulation of CDH19 Expression and Function 5 3.20e-02 0.554 1.86e-01
FCGR3A-mediated phagocytosis 121 6.19e-26 -0.554 1.49e-23
Leishmania phagocytosis 121 6.19e-26 -0.554 1.49e-23
Parasite infection 121 6.19e-26 -0.554 1.49e-23
Gamma-carboxylation of protein precursors 6 1.98e-02 -0.549 1.39e-01
Sulfide oxidation to sulfate 5 3.42e-02 -0.547 1.95e-01
Regulation of actin dynamics for phagocytic cup formation 123 5.10e-25 -0.539 8.16e-23
G1/S-Specific Transcription 29 9.87e-07 -0.525 3.72e-05
FGFR1b ligand binding and activation 5 4.23e-02 -0.524 2.22e-01
Condensation of Prometaphase Chromosomes 11 2.65e-03 -0.523 3.30e-02
Regulation of Complement cascade 96 3.48e-18 -0.513 2.48e-16
Anti-inflammatory response favouring Leishmania parasite infection 131 3.30e-24 -0.513 4.53e-22
Leishmania parasite growth and survival 131 3.30e-24 -0.513 4.53e-22
ROBO receptors bind AKAP5 7 1.92e-02 -0.511 1.37e-01
FGFR2b ligand binding and activation 6 3.14e-02 -0.507 1.85e-01
Hydrolysis of LPC 8 1.35e-02 0.504 1.10e-01
Regulation of IFNA/IFNB signaling 12 2.58e-03 -0.502 3.28e-02
Drug-mediated inhibition of CDK4/CDK6 activity 5 5.33e-02 -0.499 2.49e-01
Uptake of dietary cobalamins into enterocytes 5 5.36e-02 -0.498 2.49e-01
Ketone body metabolism 8 1.48e-02 -0.498 1.18e-01
Transcription of E2F targets under negative control by DREAM complex 19 1.97e-04 -0.493 4.30e-03
Complement cascade 100 1.68e-17 -0.492 1.15e-15


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
CD22 mediated BCR regulation 58 1.07e-26 -8.11e-01 4.12e-24
Phosphorylation of Emi1 6 9.14e-04 -7.82e-01 1.49e-02
Scavenging of heme from plasma 70 2.38e-29 -7.76e-01 2.29e-26
FCGR activation 76 2.90e-31 -7.70e-01 5.56e-28
Classical antibody-mediated complement activation 69 2.86e-27 -7.52e-01 1.83e-24
G2/M DNA replication checkpoint 5 3.64e-03 -7.51e-01 4.27e-02
Type I hemidesmosome assembly 8 3.99e-04 -7.23e-01 7.59e-03
Creation of C4 and C2 activators 71 1.08e-25 -7.18e-01 2.31e-23
Role of LAT2/NTAL/LAB on calcium mobilization 77 2.71e-25 -6.84e-01 5.21e-23
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.49e-03 -6.70e-01 8.35e-02
Unwinding of DNA 12 6.07e-05 -6.68e-01 1.53e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 2.31e-03 -6.65e-01 3.02e-02
Initial triggering of complement 79 7.12e-23 -6.40e-01 7.60e-21
FCERI mediated Ca+2 mobilization 92 3.01e-25 -6.25e-01 5.26e-23
FCGR3A-mediated IL10 synthesis 99 7.03e-27 -6.24e-01 3.38e-24
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 9.00e-23 -6.23e-01 9.10e-21
Role of phospholipids in phagocytosis 88 5.73e-24 -6.22e-01 6.88e-22
Maturation of protein 3a 9683673 9 2.06e-03 -5.93e-01 2.80e-02
Maturation of protein 3a 9694719 9 2.06e-03 -5.93e-01 2.80e-02
Interleukin-21 signaling 9 2.08e-03 -5.93e-01 2.81e-02
Binding and Uptake of Ligands by Scavenger Receptors 90 3.80e-22 -5.90e-01 3.65e-20
PI3K events in ERBB4 signaling 6 1.45e-02 5.76e-01 1.17e-01
Common Pathway of Fibrin Clot Formation 13 3.27e-04 -5.75e-01 6.76e-03
Neurotransmitter clearance 6 1.65e-02 5.65e-01 1.27e-01
Activation of NOXA and translocation to mitochondria 5 2.93e-02 -5.63e-01 1.79e-01
Protein repair 6 1.71e-02 -5.62e-01 1.29e-01
FCERI mediated MAPK activation 93 1.47e-20 -5.57e-01 1.28e-18
Synthesis of Ketone Bodies 6 1.82e-02 -5.57e-01 1.34e-01
Regulation of CDH19 Expression and Function 5 3.20e-02 5.54e-01 1.86e-01
FCGR3A-mediated phagocytosis 121 6.19e-26 -5.54e-01 1.49e-23
Leishmania phagocytosis 121 6.19e-26 -5.54e-01 1.49e-23
Parasite infection 121 6.19e-26 -5.54e-01 1.49e-23
Gamma-carboxylation of protein precursors 6 1.98e-02 -5.49e-01 1.39e-01
Sulfide oxidation to sulfate 5 3.42e-02 -5.47e-01 1.95e-01
Regulation of actin dynamics for phagocytic cup formation 123 5.10e-25 -5.39e-01 8.16e-23
G1/S-Specific Transcription 29 9.87e-07 -5.25e-01 3.72e-05
FGFR1b ligand binding and activation 5 4.23e-02 -5.24e-01 2.22e-01
Condensation of Prometaphase Chromosomes 11 2.65e-03 -5.23e-01 3.30e-02
Regulation of Complement cascade 96 3.48e-18 -5.13e-01 2.48e-16
Anti-inflammatory response favouring Leishmania parasite infection 131 3.30e-24 -5.13e-01 4.53e-22
Leishmania parasite growth and survival 131 3.30e-24 -5.13e-01 4.53e-22
ROBO receptors bind AKAP5 7 1.92e-02 -5.11e-01 1.37e-01
FGFR2b ligand binding and activation 6 3.14e-02 -5.07e-01 1.85e-01
Hydrolysis of LPC 8 1.35e-02 5.04e-01 1.10e-01
Regulation of IFNA/IFNB signaling 12 2.58e-03 -5.02e-01 3.28e-02
Drug-mediated inhibition of CDK4/CDK6 activity 5 5.33e-02 -4.99e-01 2.49e-01
Uptake of dietary cobalamins into enterocytes 5 5.36e-02 -4.98e-01 2.49e-01
Ketone body metabolism 8 1.48e-02 -4.98e-01 1.18e-01
Transcription of E2F targets under negative control by DREAM complex 19 1.97e-04 -4.93e-01 4.30e-03
Complement cascade 100 1.68e-17 -4.92e-01 1.15e-15
Regulation of HMOX1 expression and activity 5 5.85e-02 4.89e-01 2.59e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.53e-04 -4.81e-01 1.41e-02
Organic anion transporters 7 2.86e-02 -4.78e-01 1.78e-01
Interleukin-9 signaling 8 1.95e-02 -4.77e-01 1.38e-01
N-Glycan antennae elongation 12 4.26e-03 -4.76e-01 4.60e-02
Tandem pore domain potassium channels 5 6.55e-02 -4.76e-01 2.75e-01
G0 and Early G1 27 2.21e-05 -4.72e-01 6.84e-04
ChREBP activates metabolic gene expression 7 3.13e-02 -4.70e-01 1.85e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 7.01e-23 -4.70e-01 7.60e-21
PTK6 promotes HIF1A stabilization 6 4.63e-02 4.70e-01 2.34e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 4.72e-02 -4.68e-01 2.36e-01
TNFs bind their physiological receptors 25 5.84e-05 -4.64e-01 1.50e-03
Vitamin B1 (thiamin) metabolism 5 7.24e-02 4.64e-01 2.86e-01
DNA methylation 18 6.65e-04 -4.63e-01 1.15e-02
Polo-like kinase mediated events 16 1.48e-03 -4.59e-01 2.21e-02
FCERI mediated NF-kB activation 129 2.19e-19 -4.59e-01 1.68e-17
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 1.72e-02 -4.59e-01 1.29e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 5.19e-02 -4.58e-01 2.45e-01
Eicosanoids 6 5.22e-02 4.58e-01 2.46e-01
Organic cation transport 8 2.60e-02 4.55e-01 1.67e-01
Organic cation/anion/zwitterion transport 8 2.60e-02 4.55e-01 1.67e-01
Antimicrobial peptides 33 6.22e-06 -4.54e-01 2.06e-04
Diseases associated with surfactant metabolism 5 8.35e-02 -4.47e-01 3.07e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 8.14e-04 4.44e-01 1.36e-02
Interleukin-2 signaling 11 1.13e-02 -4.41e-01 9.67e-02
NADE modulates death signalling 5 9.02e-02 -4.38e-01 3.20e-01
Defects of platelet adhesion to exposed collagen 6 6.35e-02 -4.38e-01 2.69e-01
MECP2 regulates transcription of neuronal ligands 5 9.19e-02 -4.35e-01 3.23e-01
cGMP effects 12 9.10e-03 4.35e-01 8.13e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 183 3.99e-24 -4.34e-01 5.11e-22
Lysosphingolipid and LPA receptors 11 1.31e-02 -4.32e-01 1.08e-01
Cleavage of the damaged pyrimidine 26 1.38e-04 -4.32e-01 3.15e-03
Depyrimidination 26 1.38e-04 -4.32e-01 3.15e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 1.38e-04 -4.32e-01 3.15e-03
Transcriptional regulation of testis differentiation 5 9.47e-02 4.31e-01 3.30e-01
Base-Excision Repair, AP Site Formation 28 1.01e-04 -4.24e-01 2.49e-03
Cell surface interactions at the vascular wall 170 1.82e-21 -4.23e-01 1.66e-19
OAS antiviral response 8 3.89e-02 -4.22e-01 2.14e-01
Cell-extracellular matrix interactions 15 4.75e-03 -4.21e-01 4.99e-02
Transport of nucleotide sugars 9 2.90e-02 4.20e-01 1.79e-01
Scavenging by Class A Receptors 10 2.32e-02 4.14e-01 1.53e-01
Specification of primordial germ cells 6 8.28e-02 4.09e-01 3.07e-01
Transport and synthesis of PAPS 6 8.29e-02 4.09e-01 3.07e-01
Interferon alpha/beta signaling 63 2.13e-08 -4.08e-01 9.97e-07
Creatine metabolism 7 6.26e-02 -4.06e-01 2.67e-01
p75NTR negatively regulates cell cycle via SC1 5 1.16e-01 -4.05e-01 3.76e-01
Termination of O-glycan biosynthesis 15 7.22e-03 -4.01e-01 7.09e-02
Signaling by MAPK mutants 6 9.19e-02 3.97e-01 3.23e-01
PTK6 Regulates Cell Cycle 6 9.24e-02 -3.97e-01 3.23e-01
Defective LFNG causes SCDO3 5 1.25e-01 -3.96e-01 3.89e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 7.00e-02 3.96e-01 2.81e-01
Dissolution of Fibrin Clot 12 1.78e-02 3.95e-01 1.32e-01
TGFBR3 regulates TGF-beta signaling 8 5.33e-02 -3.94e-01 2.49e-01
Potential therapeutics for SARS 148 1.17e-16 -3.94e-01 7.10e-15
N-glycan antennae elongation in the medial/trans-Golgi 20 2.30e-03 -3.94e-01 3.02e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 7.14e-02 -3.94e-01 2.83e-01
Defective binding of VWF variant to GPIb:IX:V 5 1.30e-01 -3.91e-01 3.96e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 1.30e-01 -3.91e-01 3.96e-01
Packaging Of Telomere Ends 18 4.07e-03 -3.91e-01 4.60e-02
Synthesis of GDP-mannose 6 9.78e-02 -3.90e-01 3.37e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 7.43e-02 3.90e-01 2.89e-01
Nucleotide biosynthesis 12 1.98e-02 -3.88e-01 1.39e-01
CLEC7A/inflammasome pathway 6 9.97e-02 3.88e-01 3.41e-01
Signaling by the B Cell Receptor (BCR) 150 2.57e-16 -3.87e-01 1.50e-14
Glycosphingolipid biosynthesis 16 7.84e-03 -3.84e-01 7.53e-02
Displacement of DNA glycosylase by APEX1 9 4.64e-02 -3.83e-01 2.34e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 2.79e-02 -3.83e-01 1.76e-01
AMPK inhibits chREBP transcriptional activation activity 6 1.05e-01 3.83e-01 3.52e-01
Activation of Ca-permeable Kainate Receptor 8 6.14e-02 -3.82e-01 2.65e-01
Ionotropic activity of kainate receptors 8 6.14e-02 -3.82e-01 2.65e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 4.81e-02 -3.81e-01 2.37e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 8.13e-02 -3.80e-01 3.06e-01
CD163 mediating an anti-inflammatory response 8 6.25e-02 3.80e-01 2.67e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.07e-01 -3.80e-01 3.56e-01
CS/DS degradation 9 4.99e-02 3.77e-01 2.41e-01
PECAM1 interactions 12 2.39e-02 -3.77e-01 1.56e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.45e-01 -3.76e-01 4.23e-01
Formation of Fibrin Clot (Clotting Cascade) 26 9.39e-04 -3.75e-01 1.51e-02
Telomere Extension By Telomerase 23 2.00e-03 -3.72e-01 2.77e-02
Translocation of ZAP-70 to Immunological synapse 24 1.62e-03 -3.72e-01 2.33e-02
MASTL Facilitates Mitotic Progression 10 4.27e-02 -3.70e-01 2.23e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 2.15e-02 -3.68e-01 1.46e-01
Glycosphingolipid transport 7 9.19e-02 -3.68e-01 3.23e-01
Synthesis of PIPs at the Golgi membrane 16 1.09e-02 3.67e-01 9.42e-02
Purine ribonucleoside monophosphate biosynthesis 9 5.66e-02 -3.67e-01 2.54e-01
Mitochondrial RNA degradation 25 1.55e-03 3.66e-01 2.27e-02
Glycogen synthesis 11 3.62e-02 -3.65e-01 2.03e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 1.58e-01 3.64e-01 4.46e-01
Removal of the Flap Intermediate from the C-strand 17 9.41e-03 -3.64e-01 8.33e-02
DNA strand elongation 32 3.74e-04 -3.63e-01 7.33e-03
RUNX3 regulates BCL2L11 (BIM) transcription 5 1.61e-01 3.62e-01 4.50e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.91e-02 -3.62e-01 1.37e-01
Malate-aspartate shuttle 8 7.64e-02 -3.62e-01 2.96e-01
Disorders of Developmental Biology 12 3.03e-02 -3.61e-01 1.81e-01
Disorders of Nervous System Development 12 3.03e-02 -3.61e-01 1.81e-01
Loss of function of MECP2 in Rett syndrome 12 3.03e-02 -3.61e-01 1.81e-01
Pervasive developmental disorders 12 3.03e-02 -3.61e-01 1.81e-01
Cleavage of the damaged purine 21 4.19e-03 -3.61e-01 4.60e-02
Depurination 21 4.19e-03 -3.61e-01 4.60e-02
Recognition and association of DNA glycosylase with site containing an affected purine 21 4.19e-03 -3.61e-01 4.60e-02
Formation of the nephric duct 8 7.72e-02 -3.61e-01 2.98e-01
PD-1 signaling 28 9.66e-04 -3.60e-01 1.53e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 1.63e-01 -3.60e-01 4.52e-01
Diseases of hemostasis 13 2.66e-02 -3.55e-01 1.69e-01
Nuclear events stimulated by ALK signaling in cancer 33 4.15e-04 -3.55e-01 7.81e-03
Diseases of Mismatch Repair (MMR) 5 1.69e-01 -3.55e-01 4.62e-01
SMAC (DIABLO) binds to IAPs 7 1.04e-01 -3.55e-01 3.51e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.04e-01 -3.55e-01 3.51e-01
SMAC, XIAP-regulated apoptotic response 7 1.04e-01 -3.55e-01 3.51e-01
Regulation of RUNX1 Expression and Activity 18 9.16e-03 -3.55e-01 8.15e-02
Sema4D mediated inhibition of cell attachment and migration 7 1.08e-01 3.51e-01 3.57e-01
p38MAPK events 13 2.91e-02 -3.49e-01 1.79e-01
IkBA variant leads to EDA-ID 7 1.09e-01 3.49e-01 3.61e-01
LTC4-CYSLTR mediated IL4 production 5 1.77e-01 -3.49e-01 4.75e-01
Fc epsilon receptor (FCERI) signaling 179 8.03e-16 -3.49e-01 4.54e-14
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 1.10e-01 -3.49e-01 3.62e-01
tRNA processing in the mitochondrion 24 3.20e-03 3.48e-01 3.79e-02
NFE2L2 regulating ER-stress associated genes 5 1.80e-01 3.46e-01 4.83e-01
APOBEC3G mediated resistance to HIV-1 infection 5 1.84e-01 -3.43e-01 4.88e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 1.85e-01 3.42e-01 4.90e-01
Acyl chain remodeling of CL 5 1.86e-01 -3.42e-01 4.90e-01
ERBB2 Regulates Cell Motility 10 6.12e-02 3.42e-01 2.65e-01
Replacement of protamines by nucleosomes in the male pronucleus 12 4.18e-02 -3.39e-01 2.21e-01
Kinesins 51 2.95e-05 -3.38e-01 8.59e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.59e-02 -3.38e-01 1.24e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.59e-02 -3.38e-01 1.24e-01
Phase 4 - resting membrane potential 9 7.95e-02 -3.38e-01 3.02e-01
Inhibition of Signaling by Overexpressed EGFR 5 1.92e-01 3.37e-01 5.00e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 1.92e-01 3.37e-01 5.00e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 9.93e-02 3.36e-01 3.41e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 4.43e-02 -3.35e-01 2.28e-01
Leishmania infection 210 5.75e-17 -3.35e-01 3.68e-15
Parasitic Infection Pathways 210 5.75e-17 -3.35e-01 3.68e-15
RNA Polymerase I Promoter Opening 17 1.69e-02 -3.35e-01 1.29e-01
Phosphorylation of CD3 and TCR zeta chains 27 2.75e-03 -3.33e-01 3.37e-02
Glutathione synthesis and recycling 10 6.84e-02 -3.33e-01 2.79e-01
rRNA modification in the mitochondrion 8 1.04e-01 -3.32e-01 3.51e-01
Membrane binding and targetting of GAG proteins 13 3.85e-02 -3.31e-01 2.13e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 3.85e-02 -3.31e-01 2.13e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 2.01e-01 -3.31e-01 5.10e-01
PI3K events in ERBB2 signaling 11 5.87e-02 3.29e-01 2.59e-01
Transcriptional regulation of granulopoiesis 44 1.58e-04 -3.29e-01 3.50e-03
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.85e-02 -3.29e-01 2.38e-01
Synthesis of PI 5 2.03e-01 -3.28e-01 5.16e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 4.48e-03 -3.28e-01 4.80e-02
Molybdenum cofactor biosynthesis 6 1.64e-01 -3.28e-01 4.52e-01
Inhibition of DNA recombination at telomere 33 1.12e-03 -3.28e-01 1.71e-02
Ca2+ activated K+ channels 6 1.71e-01 3.23e-01 4.63e-01
Generation of second messenger molecules 38 6.15e-04 -3.21e-01 1.08e-02
Toxicity of botulinum toxin type D (botD) 5 2.18e-01 3.18e-01 5.36e-01
Toxicity of botulinum toxin type F (botF) 5 2.18e-01 3.18e-01 5.36e-01
Prostanoid ligand receptors 8 1.20e-01 -3.18e-01 3.80e-01
Base Excision Repair 56 4.00e-05 -3.17e-01 1.11e-03
RUNX3 regulates WNT signaling 8 1.21e-01 -3.17e-01 3.83e-01
Fructose catabolism 5 2.20e-01 3.17e-01 5.37e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 6.93e-02 3.16e-01 2.81e-01
Post-chaperonin tubulin folding pathway 18 2.09e-02 -3.14e-01 1.44e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.16e-02 -3.14e-01 2.20e-01
Intrinsic Pathway of Fibrin Clot Formation 15 3.51e-02 -3.14e-01 2.00e-01
Mucopolysaccharidoses 11 7.13e-02 3.14e-01 2.83e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 5.03e-02 -3.14e-01 2.42e-01
Formation of the beta-catenin:TCF transactivating complex 44 3.49e-04 -3.12e-01 7.05e-03
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 6.17e-02 -3.12e-01 2.65e-01
Transport of connexons to the plasma membrane 12 6.17e-02 -3.12e-01 2.65e-01
G2 Phase 5 2.30e-01 -3.10e-01 5.47e-01
Interleukin-10 signaling 36 1.30e-03 3.10e-01 1.95e-02
AKT phosphorylates targets in the nucleus 9 1.08e-01 3.10e-01 3.57e-01
Scavenging by Class F Receptors 5 2.31e-01 -3.09e-01 5.47e-01
Reelin signalling pathway 5 2.34e-01 -3.07e-01 5.51e-01
Mismatch Repair 15 4.01e-02 -3.06e-01 2.15e-01
Regulation of CDH11 gene transcription 5 2.37e-01 3.05e-01 5.53e-01
Degradation of cysteine and homocysteine 12 6.76e-02 -3.05e-01 2.77e-01
Eicosanoid ligand-binding receptors 13 5.95e-02 -3.02e-01 2.61e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 7.44e-07 -3.02e-01 2.92e-05
SHC1 events in ERBB4 signaling 10 1.00e-01 3.00e-01 3.42e-01
MET activates PI3K/AKT signaling 5 2.46e-01 3.00e-01 5.59e-01
Activation of caspases through apoptosome-mediated cleavage 6 2.05e-01 -2.99e-01 5.16e-01
Condensation of Prophase Chromosomes 27 7.39e-03 -2.98e-01 7.21e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 1.06e-01 2.95e-01 3.54e-01
RHO GTPases Activate NADPH Oxidases 21 1.93e-02 -2.95e-01 1.38e-01
IFNG signaling activates MAPKs 8 1.51e-01 2.93e-01 4.32e-01
NOTCH2 intracellular domain regulates transcription 11 9.21e-02 2.93e-01 3.23e-01
Serine biosynthesis 8 1.53e-01 -2.92e-01 4.36e-01
Formation of definitive endoderm 8 1.57e-01 2.89e-01 4.44e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 7.10e-02 -2.89e-01 2.83e-01
Telomere C-strand synthesis initiation 13 7.18e-02 -2.88e-01 2.84e-01
Nephron development 5 2.64e-01 -2.88e-01 5.74e-01
Regulation of MECP2 expression and activity 28 8.31e-03 -2.88e-01 7.75e-02
Keratan sulfate biosynthesis 19 2.98e-02 -2.88e-01 1.81e-01
Interleukin receptor SHC signaling 23 1.70e-02 -2.88e-01 1.29e-01
Signalling to RAS 19 3.07e-02 -2.86e-01 1.83e-01
Golgi-to-ER retrograde transport 123 4.37e-08 -2.86e-01 1.95e-06
Glutamate and glutamine metabolism 12 8.77e-02 -2.85e-01 3.15e-01
SOS-mediated signalling 7 1.93e-01 2.84e-01 5.00e-01
Activation of C3 and C5 7 1.93e-01 2.84e-01 5.00e-01
Defective factor IX causes hemophilia B 6 2.29e-01 -2.84e-01 5.44e-01
Fructose metabolism 7 1.95e-01 2.83e-01 5.02e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 1.43e-01 -2.82e-01 4.21e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.96e-01 -2.82e-01 5.05e-01
Resolution of Abasic Sites (AP sites) 38 2.65e-03 -2.82e-01 3.30e-02
Response to metal ions 6 2.33e-01 -2.81e-01 5.50e-01
Erythrocytes take up oxygen and release carbon dioxide 7 1.98e-01 -2.81e-01 5.08e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 1.69e-01 -2.81e-01 4.62e-01
Pyrimidine salvage 10 1.24e-01 -2.81e-01 3.87e-01
Activation of PUMA and translocation to mitochondria 8 1.69e-01 -2.81e-01 4.62e-01
Defective GALNT3 causes HFTC 8 1.71e-01 -2.80e-01 4.63e-01
Removal of the Flap Intermediate 14 7.05e-02 -2.79e-01 2.82e-01
Maturation of spike protein 9694548 35 4.27e-03 -2.79e-01 4.60e-02
Calcineurin activates NFAT 9 1.47e-01 -2.79e-01 4.27e-01
Endogenous sterols 17 4.69e-02 2.78e-01 2.36e-01
Processing and activation of SUMO 10 1.28e-01 -2.78e-01 3.94e-01
Ribavirin ADME 11 1.11e-01 -2.78e-01 3.63e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 8.56e-03 -2.77e-01 7.87e-02
Telomere Maintenance 78 2.30e-05 -2.77e-01 6.97e-04
Formyl peptide receptors bind formyl peptides and many other ligands 7 2.05e-01 -2.77e-01 5.16e-01
Regulation of NPAS4 gene expression 11 1.12e-01 -2.77e-01 3.66e-01
SUMO is proteolytically processed 6 2.42e-01 -2.76e-01 5.57e-01
FOXO-mediated transcription of cell death genes 16 5.65e-02 2.75e-01 2.54e-01
Processive synthesis on the C-strand of the telomere 19 3.78e-02 -2.75e-01 2.11e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.58e-02 -2.74e-01 2.94e-01
Negative regulation of FLT3 15 6.62e-02 -2.74e-01 2.75e-01
Prostacyclin signalling through prostacyclin receptor 16 5.80e-02 -2.74e-01 2.58e-01
Sema3A PAK dependent Axon repulsion 15 6.64e-02 -2.74e-01 2.75e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 1.22e-02 -2.74e-01 1.04e-01
Interaction between L1 and Ankyrins 26 1.57e-02 -2.74e-01 1.23e-01
Other interleukin signaling 18 4.48e-02 -2.73e-01 2.29e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 2.47e-01 -2.73e-01 5.59e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 2.85e-04 -2.73e-01 5.96e-03
Receptor-type tyrosine-protein phosphatases 11 1.17e-01 2.73e-01 3.76e-01
Initiation of Nuclear Envelope (NE) Reformation 19 3.94e-02 -2.73e-01 2.14e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 5.20e-02 -2.72e-01 2.46e-01
Fatty acids 6 2.50e-01 2.71e-01 5.63e-01
G1/S Transition 120 2.93e-07 -2.71e-01 1.20e-05
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 2.95e-01 -2.71e-01 5.95e-01
Transport of the SLBP independent Mature mRNA 35 5.64e-03 2.70e-01 5.86e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 2.15e-03 -2.67e-01 2.87e-02
Evasion by RSV of host interferon responses 20 3.92e-02 -2.66e-01 2.14e-01
Acetylcholine binding and downstream events 5 3.03e-01 -2.66e-01 5.99e-01
Postsynaptic nicotinic acetylcholine receptors 5 3.03e-01 -2.66e-01 5.99e-01
Biosynthesis of Lipoxins (LX) 6 2.60e-01 -2.65e-01 5.72e-01
Defective RIPK1-mediated regulated necrosis 7 2.24e-01 -2.65e-01 5.40e-01
DNA Damage/Telomere Stress Induced Senescence 42 2.97e-03 -2.65e-01 3.57e-02
Transport of the SLBP Dependant Mature mRNA 36 5.96e-03 2.65e-01 6.16e-02
Cobalamin (Cbl) metabolism 7 2.25e-01 -2.65e-01 5.42e-01
Extension of Telomeres 51 1.08e-03 -2.65e-01 1.67e-02
Endosomal/Vacuolar pathway 11 1.30e-01 2.64e-01 3.96e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 2.92e-02 -2.63e-01 1.79e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.32e-02 -2.62e-01 1.53e-01
Butyrophilin (BTN) family interactions 10 1.51e-01 2.62e-01 4.32e-01
Gap junction assembly 16 6.98e-02 -2.62e-01 2.81e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 4.77e-03 -2.61e-01 4.99e-02
p53-Independent DNA Damage Response 39 4.77e-03 -2.61e-01 4.99e-02
p53-Independent G1/S DNA damage checkpoint 39 4.77e-03 -2.61e-01 4.99e-02
Interleukin-20 family signaling 17 6.27e-02 -2.61e-01 2.67e-01
G beta:gamma signalling through BTK 15 8.11e-02 -2.60e-01 3.06e-01
Activation of AMPK downstream of NMDARs 20 4.47e-02 -2.59e-01 2.29e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 2.35e-01 -2.59e-01 5.52e-01
COPI-independent Golgi-to-ER retrograde traffic 45 2.63e-03 -2.59e-01 3.30e-02
Signal attenuation 9 1.79e-01 2.58e-01 4.82e-01
Glucagon signaling in metabolic regulation 26 2.26e-02 -2.58e-01 1.52e-01
E2F mediated regulation of DNA replication 22 3.60e-02 -2.58e-01 2.03e-01
Myoclonic epilepsy of Lafora 8 2.06e-01 -2.58e-01 5.17e-01
Glyoxylate metabolism and glycine degradation 13 1.07e-01 -2.58e-01 3.56e-01
MECP2 regulates transcription factors 5 3.19e-01 2.57e-01 6.16e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 1.65e-03 -2.57e-01 2.35e-02
POLB-Dependent Long Patch Base Excision Repair 8 2.08e-01 -2.57e-01 5.21e-01
Heme signaling 45 2.92e-03 2.56e-01 3.53e-02
PI-3K cascade:FGFR3 10 1.62e-01 2.56e-01 4.50e-01
Glucagon-type ligand receptors 19 5.39e-02 -2.55e-01 2.50e-01
Downregulation of ERBB4 signaling 8 2.12e-01 -2.55e-01 5.27e-01
Cellular response to mitochondrial stress 9 1.86e-01 -2.54e-01 4.90e-01
Platelet sensitization by LDL 16 7.84e-02 -2.54e-01 2.99e-01
Phase 3 - rapid repolarisation 7 2.45e-01 -2.54e-01 5.59e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 2.71e-04 -2.54e-01 5.77e-03
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.83e-01 -2.53e-01 5.85e-01
Regulation of KIT signaling 15 9.01e-02 -2.53e-01 3.20e-01
Chromosome Maintenance 102 1.05e-05 -2.53e-01 3.41e-04
Deposition of new CENPA-containing nucleosomes at the centromere 37 7.98e-03 -2.52e-01 7.57e-02
Nucleosome assembly 37 7.98e-03 -2.52e-01 7.57e-02
Mitotic G1 phase and G1/S transition 138 3.28e-07 -2.52e-01 1.31e-05
Polymerase switching on the C-strand of the telomere 26 2.65e-02 -2.51e-01 1.69e-01
Activation of the pre-replicative complex 32 1.39e-02 -2.51e-01 1.12e-01
Relaxin receptors 5 3.31e-01 2.51e-01 6.27e-01
Regulation of signaling by CBL 22 4.16e-02 -2.51e-01 2.20e-01
Vitamin B5 (pantothenate) metabolism 20 5.33e-02 -2.50e-01 2.49e-01
Interleukin-2 family signaling 38 7.76e-03 -2.50e-01 7.53e-02
Signaling by CSF1 (M-CSF) in myeloid cells 30 1.81e-02 -2.49e-01 1.34e-01
Translesion Synthesis by POLH 18 6.75e-02 -2.49e-01 2.77e-01
IL-6-type cytokine receptor ligand interactions 12 1.36e-01 2.49e-01 4.05e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.97e-01 -2.48e-01 5.07e-01
Propionyl-CoA catabolism 5 3.37e-01 2.48e-01 6.31e-01
Expression and translocation of olfactory receptors 49 2.67e-03 2.48e-01 3.31e-02
Translation of Structural Proteins 9694635 55 1.58e-03 -2.46e-01 2.28e-02
Orc1 removal from chromatin 58 1.19e-03 -2.46e-01 1.79e-02
Signaling by ALK 24 3.70e-02 -2.46e-01 2.07e-01
Regulated proteolysis of p75NTR 11 1.58e-01 2.46e-01 4.46e-01
COPI-mediated anterograde transport 92 4.71e-05 -2.45e-01 1.26e-03
Synthesis of PE 12 1.41e-01 2.45e-01 4.17e-01
RUNX3 regulates NOTCH signaling 14 1.14e-01 2.44e-01 3.69e-01
Transport of RCbl within the body 8 2.33e-01 -2.43e-01 5.50e-01
GP1b-IX-V activation signalling 10 1.83e-01 -2.43e-01 4.87e-01
Transport to the Golgi and subsequent modification 170 4.84e-08 -2.43e-01 2.11e-06
ADORA2B mediated anti-inflammatory cytokines production 35 1.30e-02 -2.43e-01 1.08e-01
Activation of RAS in B cells 5 3.48e-01 -2.42e-01 6.46e-01
Repression of WNT target genes 14 1.17e-01 -2.42e-01 3.76e-01
Assembly Of The HIV Virion 15 1.06e-01 -2.41e-01 3.54e-01
The NLRP3 inflammasome 16 9.59e-02 2.40e-01 3.31e-01
HS-GAG degradation 18 7.76e-02 2.40e-01 2.98e-01
Meiotic recombination 36 1.28e-02 -2.40e-01 1.07e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.72e-02 2.40e-01 1.29e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 4.23e-02 -2.39e-01 2.22e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 2.73e-01 2.39e-01 5.78e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 9.46e-04 -2.39e-01 1.51e-02
p75NTR signals via NF-kB 15 1.09e-01 2.39e-01 3.61e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.42e-01 -2.39e-01 5.57e-01
Nucleotide salvage 21 5.89e-02 -2.38e-01 2.60e-01
ER to Golgi Anterograde Transport 145 8.22e-07 -2.37e-01 3.16e-05
STAT3 nuclear events downstream of ALK signaling 11 1.73e-01 -2.37e-01 4.68e-01
Metabolic disorders of biological oxidation enzymes 23 4.92e-02 2.37e-01 2.39e-01
Coenzyme A biosynthesis 7 2.78e-01 -2.37e-01 5.83e-01
Androgen biosynthesis 5 3.60e-01 2.36e-01 6.58e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 9.04e-03 -2.36e-01 8.12e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 8.36e-02 -2.36e-01 3.07e-01
Cargo concentration in the ER 31 2.36e-02 -2.35e-01 1.55e-01
Na+/Cl- dependent neurotransmitter transporters 7 2.82e-01 2.35e-01 5.85e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 2.15e-02 2.35e-01 1.46e-01
Surfactant metabolism 20 6.95e-02 -2.34e-01 2.81e-01
Lysine catabolism 10 1.99e-01 -2.34e-01 5.10e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 1.05e-01 -2.34e-01 3.53e-01
Formation of tubulin folding intermediates by CCT/TriC 21 6.37e-02 -2.34e-01 2.69e-01
SUMOylation of intracellular receptors 26 3.92e-02 2.34e-01 2.14e-01
Apoptotic cleavage of cellular proteins 35 1.71e-02 -2.33e-01 1.29e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 4.40e-02 -2.33e-01 2.27e-01
RHO GTPases activate CIT 18 8.77e-02 -2.33e-01 3.15e-01
ADP signalling through P2Y purinoceptor 12 18 8.78e-02 -2.32e-01 3.15e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 2.03e-01 -2.32e-01 5.16e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 1.33e-02 -2.32e-01 1.09e-01
Processive synthesis on the lagging strand 15 1.20e-01 -2.32e-01 3.80e-01
Cytochrome P450 - arranged by substrate type 33 2.17e-02 2.31e-01 1.47e-01
Hemostasis 553 1.54e-20 -2.31e-01 1.29e-18
Nitric oxide stimulates guanylate cyclase 15 1.22e-01 2.30e-01 3.85e-01
Defects in cobalamin (B12) metabolism 13 1.50e-01 -2.30e-01 4.32e-01
Urea cycle 6 3.30e-01 -2.30e-01 6.25e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 3.74e-01 2.30e-01 6.66e-01
SUMOylation of ubiquitinylation proteins 39 1.33e-02 2.29e-01 1.09e-01
Reduction of cytosolic Ca++ levels 9 2.36e-01 -2.28e-01 5.53e-01
RUNX1 regulates estrogen receptor mediated transcription 6 3.35e-01 -2.27e-01 6.30e-01
Regulation of ornithine decarboxylase (ODC) 38 1.53e-02 -2.27e-01 1.22e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.81e-03 -2.27e-01 2.54e-02
Phase 2 - plateau phase 12 1.73e-01 -2.27e-01 4.68e-01
p130Cas linkage to MAPK signaling for integrins 11 1.93e-01 -2.27e-01 5.00e-01
Cyclin E associated events during G1/S transition 73 8.15e-04 -2.27e-01 1.36e-02
Nucleotide-like (purinergic) receptors 14 1.44e-01 -2.26e-01 4.21e-01
FGFR2 ligand binding and activation 9 2.41e-01 -2.26e-01 5.57e-01
Defective C1GALT1C1 causes TNPS 9 2.41e-01 -2.26e-01 5.57e-01
Cyclin A:Cdk2-associated events at S phase entry 75 7.32e-04 -2.26e-01 1.25e-02
PKA activation in glucagon signalling 14 1.45e-01 -2.25e-01 4.23e-01
Telomere C-strand (Lagging Strand) Synthesis 34 2.33e-02 -2.25e-01 1.53e-01
TNFR2 non-canonical NF-kB pathway 84 3.80e-04 -2.24e-01 7.36e-03
Synthesis of 5-eicosatetraenoic acids 7 3.04e-01 2.24e-01 5.99e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 7.23e-03 -2.24e-01 7.09e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 2.84e-02 2.24e-01 1.78e-01
FLT3 signaling through SRC family kinases 6 3.43e-01 -2.24e-01 6.39e-01
Regulation of PTEN localization 9 2.46e-01 -2.23e-01 5.59e-01
Keratan sulfate degradation 9 2.47e-01 2.23e-01 5.59e-01
SUMOylation of transcription factors 16 1.22e-01 2.23e-01 3.85e-01
Methionine salvage pathway 6 3.44e-01 -2.23e-01 6.41e-01
eNOS activation 10 2.22e-01 -2.23e-01 5.39e-01
Formation of xylulose-5-phosphate 5 3.88e-01 -2.23e-01 6.66e-01
GABA synthesis, release, reuptake and degradation 12 1.81e-01 -2.23e-01 4.84e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.88e-01 2.23e-01 6.66e-01
GRB2 events in ERBB2 signaling 11 2.01e-01 2.23e-01 5.10e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 6.45e-03 -2.23e-01 6.56e-02
N-glycan trimming and elongation in the cis-Golgi 5 3.89e-01 2.23e-01 6.66e-01
Vif-mediated degradation of APOBEC3G 41 1.39e-02 -2.22e-01 1.12e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 5.48e-02 2.22e-01 2.52e-01
Defective GALNT12 causes CRCS1 8 2.77e-01 -2.22e-01 5.83e-01
Purine salvage 12 1.84e-01 -2.22e-01 4.88e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 6.65e-02 -2.21e-01 2.75e-01
Azathioprine ADME 20 8.71e-02 -2.21e-01 3.14e-01
Downstream signal transduction 27 4.71e-02 -2.21e-01 2.36e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 3.09e-02 -2.20e-01 1.84e-01
Cellular hexose transport 14 1.54e-01 -2.20e-01 4.36e-01
Interleukin-6 signaling 10 2.28e-01 -2.20e-01 5.44e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 1.17e-01 2.20e-01 3.76e-01
Glycogen metabolism 21 8.16e-02 -2.19e-01 3.06e-01
HDR through MMEJ (alt-NHEJ) 12 1.90e-01 -2.19e-01 4.97e-01
Ubiquitin-dependent degradation of Cyclin D 39 1.82e-02 -2.19e-01 1.34e-01
Budding and maturation of HIV virion 26 5.43e-02 -2.18e-01 2.51e-01
Assembly of the ORC complex at the origin of replication 23 7.03e-02 -2.18e-01 2.82e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.56e-02 -2.16e-01 1.23e-01
Proteasome assembly 50 8.51e-03 -2.15e-01 7.86e-02
CD28 dependent Vav1 pathway 12 1.98e-01 -2.14e-01 5.09e-01
Activation of kainate receptors upon glutamate binding 25 6.38e-02 -2.14e-01 2.69e-01
SCF(Skp2)-mediated degradation of p27/p21 50 8.94e-03 -2.14e-01 8.06e-02
Hh mutants are degraded by ERAD 42 1.67e-02 -2.13e-01 1.28e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 3.66e-01 2.13e-01 6.61e-01
Regulation of FOXO transcriptional activity by acetylation 10 2.44e-01 2.13e-01 5.58e-01
PIWI-interacting RNA (piRNA) biogenesis 23 7.74e-02 -2.13e-01 2.98e-01
Gap junction trafficking 27 5.59e-02 -2.13e-01 2.53e-01
COPII-mediated vesicle transport 67 2.70e-03 -2.12e-01 3.33e-02
Olfactory Signaling Pathway 54 7.12e-03 2.12e-01 7.09e-02
Translation of Structural Proteins 9683701 29 4.86e-02 -2.12e-01 2.38e-01
Somitogenesis 41 1.91e-02 -2.12e-01 1.37e-01
Postmitotic nuclear pore complex (NPC) reformation 27 5.73e-02 2.11e-01 2.56e-01
GDP-fucose biosynthesis 6 3.70e-01 2.11e-01 6.65e-01
Advanced glycosylation endproduct receptor signaling 12 2.05e-01 -2.11e-01 5.16e-01
Vpr-mediated nuclear import of PICs 34 3.31e-02 2.11e-01 1.91e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.45e-02 -2.11e-01 1.60e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.82e-02 2.11e-01 1.34e-01
HSF1 activation 25 6.88e-02 -2.10e-01 2.80e-01
SLBP independent Processing of Histone Pre-mRNAs 10 2.50e-01 2.10e-01 5.63e-01
RHOV GTPase cycle 36 2.91e-02 -2.10e-01 1.79e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 4.54e-03 -2.10e-01 4.85e-02
Intraflagellar transport 47 1.28e-02 -2.10e-01 1.07e-01
P2Y receptors 10 2.51e-01 -2.10e-01 5.63e-01
DNA Replication 128 4.19e-05 -2.10e-01 1.15e-03
Gap junction trafficking and regulation 29 5.07e-02 -2.10e-01 2.43e-01
Assembly of the pre-replicative complex 87 7.35e-04 -2.09e-01 1.25e-02
AURKA Activation by TPX2 72 2.12e-03 -2.09e-01 2.85e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 5.10e-02 -2.09e-01 2.43e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.27e-02 -2.09e-01 1.89e-01
Hedgehog ligand biogenesis 47 1.34e-02 -2.08e-01 1.10e-01
Late SARS-CoV-2 Infection Events 63 4.22e-03 -2.08e-01 4.60e-02
Kidney development 16 1.49e-01 -2.08e-01 4.31e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 3.08e-01 -2.08e-01 6.04e-01
HDL assembly 6 3.78e-01 2.08e-01 6.66e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.87e-02 2.07e-01 1.36e-01
Metabolism of polyamines 46 1.51e-02 -2.07e-01 1.21e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 7.34e-02 -2.07e-01 2.87e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 1.55e-02 -2.06e-01 1.23e-01
Defective pyroptosis 27 6.41e-02 -2.06e-01 2.70e-01
ERBB2 Activates PTK6 Signaling 8 3.14e-01 2.06e-01 6.07e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 2.39e-01 -2.05e-01 5.57e-01
Dermatan sulfate biosynthesis 6 3.86e-01 2.05e-01 6.66e-01
G2/M Transition 177 2.71e-06 -2.04e-01 9.65e-05
CASP8 activity is inhibited 11 2.41e-01 -2.04e-01 5.57e-01
Dimerization of procaspase-8 11 2.41e-01 -2.04e-01 5.57e-01
Regulation by c-FLIP 11 2.41e-01 -2.04e-01 5.57e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 3.19e-02 -2.04e-01 1.86e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 5.77e-02 2.04e-01 2.57e-01
Mitotic G2-G2/M phases 179 2.65e-06 -2.03e-01 9.60e-05
Termination of translesion DNA synthesis 32 4.64e-02 -2.03e-01 2.34e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 6.07e-03 -2.03e-01 6.24e-02
APC/C-mediated degradation of cell cycle proteins 75 2.38e-03 -2.03e-01 3.05e-02
Regulation of mitotic cell cycle 75 2.38e-03 -2.03e-01 3.05e-02
Deactivation of the beta-catenin transactivating complex 36 3.52e-02 -2.03e-01 2.00e-01
G2/M Checkpoints 126 8.49e-05 -2.03e-01 2.12e-03
Free fatty acids regulate insulin secretion 10 2.67e-01 2.03e-01 5.77e-01
PKR-mediated signaling 67 4.12e-03 -2.03e-01 4.60e-02
PCNA-Dependent Long Patch Base Excision Repair 21 1.08e-01 -2.03e-01 3.57e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.90e-01 2.03e-01 6.66e-01
Meiotic synapsis 43 2.15e-02 -2.03e-01 1.46e-01
GRB2 events in EGFR signaling 10 2.69e-01 2.02e-01 5.78e-01
Vesicle-mediated transport 663 8.00e-19 -2.02e-01 5.91e-17
Interactions of Vpr with host cellular proteins 37 3.38e-02 2.02e-01 1.94e-01
Platelet Adhesion to exposed collagen 14 1.92e-01 -2.01e-01 5.00e-01
Regulation of APC/C activators between G1/S and early anaphase 68 4.08e-03 -2.01e-01 4.60e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 1.19e-01 -2.01e-01 3.80e-01
DNA Replication Pre-Initiation 103 4.31e-04 -2.01e-01 7.89e-03
Hh mutants abrogate ligand secretion 43 2.29e-02 -2.00e-01 1.53e-01
S Phase 150 2.32e-05 -2.00e-01 6.97e-04
NS1 Mediated Effects on Host Pathways 40 2.85e-02 2.00e-01 1.78e-01
Nef and signal transduction 8 3.28e-01 -2.00e-01 6.23e-01
The canonical retinoid cycle in rods (twilight vision) 9 3.00e-01 -2.00e-01 5.97e-01
O-linked glycosylation of mucins 46 1.95e-02 -1.99e-01 1.38e-01
Effects of PIP2 hydrolysis 24 9.15e-02 -1.99e-01 3.23e-01
Sodium/Proton exchangers 7 3.63e-01 -1.99e-01 6.58e-01
Presynaptic depolarization and calcium channel opening 8 3.31e-01 1.98e-01 6.27e-01
EGFR interacts with phospholipase C-gamma 6 4.00e-01 1.98e-01 6.70e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 2.57e-01 1.97e-01 5.68e-01
Cytosolic sulfonation of small molecules 18 1.48e-01 1.97e-01 4.28e-01
Interleukin-1 processing 8 3.35e-01 1.97e-01 6.30e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 8.42e-03 -1.97e-01 7.82e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 4.04e-01 -1.97e-01 6.74e-01
Platelet calcium homeostasis 22 1.11e-01 -1.96e-01 3.63e-01
Factors involved in megakaryocyte development and platelet production 128 1.26e-04 -1.96e-01 2.99e-03
Metabolism of nitric oxide: NOS3 activation and regulation 13 2.21e-01 -1.96e-01 5.37e-01
Methylation 13 2.21e-01 1.96e-01 5.37e-01
Synthesis of DNA 108 4.36e-04 -1.96e-01 7.89e-03
Caspase activation via Dependence Receptors in the absence of ligand 9 3.09e-01 -1.96e-01 6.05e-01
Heme biosynthesis 13 2.23e-01 -1.95e-01 5.39e-01
Degradation of beta-catenin by the destruction complex 72 4.18e-03 -1.95e-01 4.60e-02
Activation of ATR in response to replication stress 37 4.01e-02 -1.95e-01 2.15e-01
Signaling by Hippo 18 1.52e-01 1.95e-01 4.35e-01
Phosphate bond hydrolysis by NTPDase proteins 6 4.10e-01 1.94e-01 6.77e-01
Negative regulation of NOTCH4 signaling 44 2.61e-02 -1.94e-01 1.67e-01
Erythrocytes take up carbon dioxide and release oxygen 11 2.67e-01 -1.93e-01 5.77e-01
O2/CO2 exchange in erythrocytes 11 2.67e-01 -1.93e-01 5.77e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 4.08e-06 -1.93e-01 1.43e-04
TICAM1-dependent activation of IRF3/IRF7 13 2.28e-01 -1.93e-01 5.44e-01
Cell recruitment (pro-inflammatory response) 25 9.55e-02 1.93e-01 3.31e-01
Purinergic signaling in leishmaniasis infection 25 9.55e-02 1.93e-01 3.31e-01
RHO GTPases Activate WASPs and WAVEs 35 4.90e-02 -1.92e-01 2.39e-01
TCF dependent signaling in response to WNT 151 4.62e-05 -1.92e-01 1.25e-03
Regulation of innate immune responses to cytosolic DNA 14 2.14e-01 -1.92e-01 5.30e-01
CTLA4 inhibitory signaling 21 1.28e-01 -1.92e-01 3.94e-01
RHO GTPases activate PAKs 20 1.38e-01 -1.92e-01 4.10e-01
PRC2 methylates histones and DNA 27 8.52e-02 -1.91e-01 3.11e-01
G beta:gamma signalling through CDC42 17 1.72e-01 -1.91e-01 4.66e-01
Activation of G protein gated Potassium channels 18 1.62e-01 -1.91e-01 4.50e-01
G protein gated Potassium channels 18 1.62e-01 -1.91e-01 4.50e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 1.62e-01 -1.91e-01 4.50e-01
Fertilization 12 2.54e-01 1.90e-01 5.64e-01
Attenuation phase 22 1.23e-01 -1.90e-01 3.85e-01
Degradation of DVL 43 3.11e-02 -1.90e-01 1.85e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 4.22e-01 -1.89e-01 6.84e-01
Protein folding 83 2.85e-03 -1.89e-01 3.46e-02
The phototransduction cascade 26 9.51e-02 -1.89e-01 3.31e-01
EPHA-mediated growth cone collapse 21 1.34e-01 -1.89e-01 4.02e-01
FLT3 signaling by CBL mutants 7 3.87e-01 -1.89e-01 6.66e-01
DNA Double Strand Break Response 47 2.53e-02 -1.89e-01 1.64e-01
Vpu mediated degradation of CD4 39 4.15e-02 -1.89e-01 2.20e-01
Rev-mediated nuclear export of HIV RNA 35 5.36e-02 1.89e-01 2.49e-01
Platelet degranulation 104 9.06e-04 -1.88e-01 1.49e-02
Synthesis of PIPs at the late endosome membrane 11 2.80e-01 1.88e-01 5.83e-01
Meiosis 66 8.18e-03 -1.88e-01 7.66e-02
Histidine catabolism 7 3.89e-01 -1.88e-01 6.66e-01
G1/S DNA Damage Checkpoints 54 1.71e-02 -1.88e-01 1.29e-01
DARPP-32 events 22 1.28e-01 -1.87e-01 3.94e-01
Miscellaneous substrates 7 3.91e-01 1.87e-01 6.66e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.98e-02 -1.87e-01 1.39e-01
SUMOylation of SUMOylation proteins 35 5.58e-02 1.87e-01 2.53e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 6.77e-02 1.87e-01 2.77e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 6.77e-02 1.87e-01 2.77e-01
Gain-of-function MRAS complexes activate RAF signaling 8 3.62e-01 1.86e-01 6.58e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 3.62e-01 1.86e-01 6.58e-01
Signaling by MRAS-complex mutants 8 3.62e-01 1.86e-01 6.58e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 3.95e-01 1.86e-01 6.67e-01
Pausing and recovery of Tat-mediated HIV elongation 30 7.84e-02 -1.86e-01 2.99e-01
Tat-mediated HIV elongation arrest and recovery 30 7.84e-02 -1.86e-01 2.99e-01
SLC15A4:TASL-dependent IRF5 activation 6 4.32e-01 1.85e-01 6.94e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 6.53e-03 1.85e-01 6.60e-02
CLEC7A (Dectin-1) induces NFAT activation 11 2.87e-01 -1.85e-01 5.91e-01
Folding of actin by CCT/TriC 10 3.11e-01 -1.85e-01 6.06e-01
NPAS4 regulates expression of target genes 16 2.00e-01 1.85e-01 5.10e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 4.34e-01 1.84e-01 6.96e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 2.69e-01 -1.84e-01 5.78e-01
Activation of RAC1 11 2.90e-01 -1.84e-01 5.92e-01
Respiratory syncytial virus (RSV) attachment and entry 17 1.88e-01 1.84e-01 4.95e-01
Formation of apoptosome 11 2.91e-01 -1.84e-01 5.92e-01
Regulation of the apoptosome activity 11 2.91e-01 -1.84e-01 5.92e-01
Regulation of endogenous retroelements 92 2.34e-03 -1.84e-01 3.04e-02
Response to elevated platelet cytosolic Ca2+ 108 1.02e-03 -1.83e-01 1.59e-02
Abacavir ADME 5 4.79e-01 -1.83e-01 7.28e-01
Arachidonate production from DAG 5 4.80e-01 -1.82e-01 7.28e-01
Stabilization of p53 43 3.92e-02 -1.82e-01 2.14e-01
Regulation of PLK1 Activity at G2/M Transition 87 3.44e-03 -1.81e-01 4.05e-02
Apoptotic cleavage of cell adhesion proteins 8 3.75e-01 1.81e-01 6.66e-01
RHO GTPases Activate Formins 127 4.21e-04 -1.81e-01 7.85e-03
Activation of SMO 14 2.41e-01 -1.81e-01 5.57e-01
Defective CFTR causes cystic fibrosis 47 3.19e-02 -1.81e-01 1.86e-01
p75NTR recruits signalling complexes 12 2.78e-01 1.81e-01 5.83e-01
ARMS-mediated activation 6 4.44e-01 -1.80e-01 7.03e-01
Regulation of RAS by GAPs 55 2.08e-02 -1.80e-01 1.43e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.43e-01 1.80e-01 4.21e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 4.10e-01 1.80e-01 6.77e-01
Lagging Strand Synthesis 20 1.64e-01 -1.80e-01 4.52e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 2.63e-02 1.80e-01 1.68e-01
GPER1 signaling 38 5.55e-02 -1.80e-01 2.53e-01
SARS-CoV-2 modulates autophagy 11 3.03e-01 1.79e-01 5.99e-01
Chaperonin-mediated protein folding 77 6.57e-03 -1.79e-01 6.61e-02
Regulation of CDH11 mRNA translation by microRNAs 8 3.81e-01 -1.79e-01 6.66e-01
Regulation of NPAS4 mRNA translation 8 3.81e-01 -1.79e-01 6.66e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 4.49e-01 -1.79e-01 7.03e-01
Loss of Nlp from mitotic centrosomes 69 1.05e-02 -1.78e-01 9.04e-02
Loss of proteins required for interphase microtubule organization from the centrosome 69 1.05e-02 -1.78e-01 9.04e-02
E2F-enabled inhibition of pre-replication complex formation 9 3.55e-01 -1.78e-01 6.52e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 4.50e-01 1.78e-01 7.03e-01
EML4 and NUDC in mitotic spindle formation 106 1.56e-03 -1.78e-01 2.27e-02
Resolution of Sister Chromatid Cohesion 115 1.02e-03 -1.77e-01 1.59e-02
RHO GTPase Effectors 257 1.04e-06 -1.77e-01 3.82e-05
TBC/RABGAPs 45 4.04e-02 -1.77e-01 2.16e-01
Assembly of active LPL and LIPC lipase complexes 10 3.34e-01 -1.77e-01 6.30e-01
Recruitment of NuMA to mitotic centrosomes 88 4.22e-03 -1.76e-01 4.60e-02
Cell Cycle 609 1.03e-13 -1.76e-01 5.48e-12
Nuclear Receptor transcription pathway 38 6.00e-02 1.76e-01 2.63e-01
Signaling by FGFR3 in disease 14 2.54e-01 1.76e-01 5.64e-01
Carnitine shuttle 12 2.91e-01 -1.76e-01 5.92e-01
Adaptive Immune System 765 1.18e-16 -1.76e-01 7.10e-15
TRAIL signaling 8 3.90e-01 -1.76e-01 6.66e-01
Signal regulatory protein family interactions 13 2.73e-01 -1.76e-01 5.78e-01
Cell Cycle, Mitotic 487 3.40e-11 -1.75e-01 1.77e-09
Beta-catenin phosphorylation cascade 17 2.11e-01 -1.75e-01 5.27e-01
Regulation of Apoptosis 40 5.59e-02 -1.75e-01 2.53e-01
Elevation of cytosolic Ca2+ levels 13 2.77e-01 -1.74e-01 5.83e-01
CDH11 homotypic and heterotypic interactions 5 5.01e-01 1.74e-01 7.45e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.33e-01 -1.74e-01 4.00e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.33e-01 -1.74e-01 4.00e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.33e-01 -1.74e-01 4.00e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.33e-01 -1.74e-01 4.00e-01
TNFR1-mediated ceramide production 6 4.62e-01 -1.74e-01 7.13e-01
Switching of origins to a post-replicative state 79 7.84e-03 -1.73e-01 7.53e-02
Apoptotic execution phase 46 4.25e-02 -1.73e-01 2.22e-01
TCR signaling 110 1.74e-03 -1.73e-01 2.46e-02
Beta-oxidation of very long chain fatty acids 11 3.23e-01 -1.72e-01 6.19e-01
TRAF3-dependent IRF activation pathway 13 2.83e-01 -1.72e-01 5.85e-01
RHO GTPases activate IQGAPs 25 1.37e-01 -1.72e-01 4.07e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 2.66e-01 1.72e-01 5.76e-01
PI-3K cascade:FGFR1 13 2.83e-01 1.72e-01 5.85e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 2.05e-02 -1.72e-01 1.43e-01
Pyruvate metabolism 44 4.97e-02 -1.71e-01 2.41e-01
Biotin transport and metabolism 11 3.27e-01 -1.71e-01 6.23e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.57e-01 -1.70e-01 4.45e-01
mRNA Editing 8 4.05e-01 -1.70e-01 6.74e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 5.67e-02 -1.70e-01 2.54e-01
RAB geranylgeranylation 62 2.07e-02 -1.70e-01 1.43e-01
Degradation of GLI2 by the proteasome 45 4.87e-02 -1.70e-01 2.38e-01
GLI3 is processed to GLI3R by the proteasome 45 4.87e-02 -1.70e-01 2.38e-01
FOXO-mediated transcription of cell cycle genes 14 2.71e-01 1.70e-01 5.78e-01
Mitotic Prometaphase 192 5.04e-05 -1.70e-01 1.31e-03
APC truncation mutants have impaired AXIN binding 14 2.72e-01 -1.69e-01 5.78e-01
AXIN missense mutants destabilize the destruction complex 14 2.72e-01 -1.69e-01 5.78e-01
Signaling by AMER1 mutants 14 2.72e-01 -1.69e-01 5.78e-01
Signaling by APC mutants 14 2.72e-01 -1.69e-01 5.78e-01
Signaling by AXIN mutants 14 2.72e-01 -1.69e-01 5.78e-01
Truncations of AMER1 destabilize the destruction complex 14 2.72e-01 -1.69e-01 5.78e-01
Acetylcholine regulates insulin secretion 9 3.79e-01 1.69e-01 6.66e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 2.91e-01 -1.69e-01 5.92e-01
Molecules associated with elastic fibres 26 1.38e-01 -1.68e-01 4.10e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 9.03e-02 -1.68e-01 3.20e-01
Defects in vitamin and cofactor metabolism 21 1.83e-01 -1.68e-01 4.87e-01
Costimulation by the CD28 family 74 1.26e-02 -1.68e-01 1.07e-01
Reversible hydration of carbon dioxide 8 4.12e-01 1.68e-01 6.79e-01
NrCAM interactions 6 4.78e-01 -1.67e-01 7.28e-01
Retrograde neurotrophin signalling 12 3.16e-01 -1.67e-01 6.10e-01
Class I peroxisomal membrane protein import 20 1.95e-01 -1.67e-01 5.04e-01
Reactions specific to the complex N-glycan synthesis pathway 7 4.44e-01 -1.67e-01 7.03e-01
BBSome-mediated cargo-targeting to cilium 23 1.66e-01 -1.67e-01 4.58e-01
Centrosome maturation 81 9.56e-03 -1.67e-01 8.35e-02
Recruitment of mitotic centrosome proteins and complexes 81 9.56e-03 -1.67e-01 8.35e-02
Impaired BRCA2 binding to PALB2 24 1.59e-01 -1.66e-01 4.47e-01
Interleukin-23 signaling 7 4.47e-01 -1.66e-01 7.03e-01
Glycogen breakdown (glycogenolysis) 12 3.20e-01 -1.66e-01 6.16e-01
SUMOylation of DNA methylation proteins 16 2.53e-01 -1.65e-01 5.64e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 36 8.71e-02 1.65e-01 3.14e-01
p53-Dependent G1 DNA Damage Response 52 4.02e-02 -1.65e-01 2.15e-01
p53-Dependent G1/S DNA damage checkpoint 52 4.02e-02 -1.65e-01 2.15e-01
Synthesis of pyrophosphates in the cytosol 8 4.21e-01 -1.64e-01 6.84e-01
HDACs deacetylate histones 45 5.65e-02 -1.64e-01 2.54e-01
PKA activation 15 2.71e-01 -1.64e-01 5.78e-01
tRNA Aminoacylation 42 6.58e-02 -1.64e-01 2.75e-01
Signaling by KIT in disease 20 2.05e-01 -1.64e-01 5.16e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.05e-01 -1.64e-01 5.16e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 4.38e-02 -1.63e-01 2.27e-01
Signaling by ALK fusions and activated point mutants 89 8.04e-03 -1.63e-01 7.57e-02
Signaling by ALK in cancer 89 8.04e-03 -1.63e-01 7.57e-02
Nef Mediated CD8 Down-regulation 7 4.58e-01 -1.62e-01 7.12e-01
Constitutive Signaling by Overexpressed ERBB2 11 3.52e-01 -1.62e-01 6.50e-01
Aryl hydrocarbon receptor signalling 6 4.92e-01 -1.62e-01 7.38e-01
DNA Double-Strand Break Repair 137 1.09e-03 -1.62e-01 1.67e-02
AKT phosphorylates targets in the cytosol 14 2.95e-01 1.62e-01 5.95e-01
Translesion synthesis by REV1 16 2.63e-01 -1.62e-01 5.73e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.79e-01 1.61e-01 5.83e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 1.40e-01 -1.61e-01 4.14e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 4.61e-01 -1.61e-01 7.13e-01
VEGF binds to VEGFR leading to receptor dimerization 5 5.34e-01 1.60e-01 7.74e-01
VEGF ligand-receptor interactions 5 5.34e-01 1.60e-01 7.74e-01
PKA-mediated phosphorylation of CREB 17 2.53e-01 -1.60e-01 5.64e-01
Signalling to ERKs 32 1.17e-01 -1.60e-01 3.76e-01
Homology Directed Repair 110 3.71e-03 -1.60e-01 4.32e-02
Transport of Mature Transcript to Cytoplasm 81 1.28e-02 1.60e-01 1.07e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 1.61e-02 -1.60e-01 1.25e-01
RAF-independent MAPK1/3 activation 21 2.05e-01 1.60e-01 5.16e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 90 8.89e-03 -1.60e-01 8.06e-02
Amplification of signal from the kinetochores 90 8.89e-03 -1.60e-01 8.06e-02
Glycine degradation 7 4.65e-01 -1.60e-01 7.16e-01
PI-3K cascade:FGFR4 11 3.60e-01 1.59e-01 6.58e-01
Hedgehog ‘off’ state 91 8.70e-03 -1.59e-01 7.96e-02
Heme degradation 10 3.84e-01 1.59e-01 6.66e-01
CDK-mediated phosphorylation and removal of Cdc6 60 3.32e-02 -1.59e-01 1.91e-01
Zinc influx into cells by the SLC39 gene family 9 4.09e-01 -1.59e-01 6.77e-01
RHOBTB3 ATPase cycle 10 3.85e-01 -1.59e-01 6.66e-01
GAB1 signalosome 14 3.06e-01 1.58e-01 6.02e-01
Cytochrome c-mediated apoptotic response 13 3.24e-01 -1.58e-01 6.20e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 3.87e-01 -1.58e-01 6.66e-01
Transcriptional regulation by RUNX1 170 3.98e-04 -1.57e-01 7.59e-03
Growth hormone receptor signaling 20 2.23e-01 -1.57e-01 5.39e-01
ADP signalling through P2Y purinoceptor 1 21 2.12e-01 -1.57e-01 5.27e-01
Mitochondrial tRNA aminoacylation 21 2.12e-01 -1.57e-01 5.27e-01
Nuclear import of Rev protein 34 1.13e-01 1.57e-01 3.66e-01
Gluconeogenesis 19 2.36e-01 -1.57e-01 5.53e-01
HIV elongation arrest and recovery 32 1.26e-01 -1.56e-01 3.91e-01
Pausing and recovery of HIV elongation 32 1.26e-01 -1.56e-01 3.91e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.15e-01 -1.56e-01 3.71e-01
Degradation of AXIN 42 8.02e-02 -1.56e-01 3.03e-01
Circadian Clock 67 2.73e-02 1.56e-01 1.72e-01
IRAK1 recruits IKK complex 14 3.13e-01 1.56e-01 6.07e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 3.13e-01 1.56e-01 6.07e-01
Signaling by FGFR2 IIIa TM 18 2.53e-01 -1.56e-01 5.64e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 3.51e-01 -1.56e-01 6.50e-01
Release of apoptotic factors from the mitochondria 6 5.10e-01 -1.55e-01 7.54e-01
Separation of Sister Chromatids 167 5.32e-04 -1.55e-01 9.46e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.63e-01 -1.55e-01 4.50e-01
Platelet homeostasis 69 2.58e-02 -1.55e-01 1.67e-01
Cyclin D associated events in G1 47 6.61e-02 -1.55e-01 2.75e-01
G1 Phase 47 6.61e-02 -1.55e-01 2.75e-01
SUMOylation of RNA binding proteins 47 6.62e-02 1.55e-01 2.75e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 8.28e-02 -1.55e-01 3.07e-01
Metabolism of non-coding RNA 53 5.14e-02 1.55e-01 2.44e-01
snRNP Assembly 53 5.14e-02 1.55e-01 2.44e-01
tRNA modification in the mitochondrion 9 4.22e-01 1.55e-01 6.84e-01
Cell Cycle Checkpoints 245 3.08e-05 -1.55e-01 8.84e-04
Formation of annular gap junctions 10 3.98e-01 -1.54e-01 6.68e-01
Cargo trafficking to the periciliary membrane 48 6.48e-02 -1.54e-01 2.72e-01
Downstream TCR signaling 89 1.20e-02 -1.54e-01 1.02e-01
Alternative complement activation 5 5.52e-01 -1.54e-01 7.87e-01
Defective B4GALT7 causes EDS, progeroid type 10 4.02e-01 1.53e-01 6.71e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 3.39e-01 1.53e-01 6.34e-01
Dectin-2 family 18 2.61e-01 -1.53e-01 5.72e-01
Smooth Muscle Contraction 34 1.23e-01 -1.53e-01 3.85e-01
Degradation of GLI1 by the proteasome 46 7.29e-02 -1.53e-01 2.86e-01
NF-kB is activated and signals survival 12 3.60e-01 1.52e-01 6.58e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 7.22e-03 -1.52e-01 7.09e-02
APC/C:Cdc20 mediated degradation of Securin 55 5.08e-02 -1.52e-01 2.43e-01
MAPK6/MAPK4 signaling 69 2.90e-02 -1.52e-01 1.79e-01
DNA Damage Bypass 47 7.14e-02 -1.52e-01 2.83e-01
Metabolism of Angiotensinogen to Angiotensins 12 3.62e-01 -1.52e-01 6.58e-01
Asparagine N-linked glycosylation 284 1.11e-05 -1.52e-01 3.54e-04
VxPx cargo-targeting to cilium 19 2.53e-01 -1.51e-01 5.64e-01
SHC1 events in EGFR signaling 11 3.85e-01 1.51e-01 6.66e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.10e-01 -1.51e-01 5.24e-01
Formation of axial mesoderm 6 5.22e-01 1.51e-01 7.67e-01
Platelet Aggregation (Plug Formation) 28 1.69e-01 -1.50e-01 4.62e-01
rRNA processing in the mitochondrion 24 2.05e-01 1.50e-01 5.16e-01
RIPK1-mediated regulated necrosis 31 1.50e-01 -1.49e-01 4.32e-01
Regulation of necroptotic cell death 31 1.50e-01 -1.49e-01 4.32e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 3.93e-01 1.49e-01 6.67e-01
RUNX3 Regulates Immune Response and Cell Migration 5 5.65e-01 -1.49e-01 7.97e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.35e-01 -1.48e-01 4.03e-01
RHO GTPases activate PKNs 46 8.23e-02 -1.48e-01 3.07e-01
Interactions of Rev with host cellular proteins 37 1.21e-01 1.47e-01 3.83e-01
Basigin interactions 21 2.43e-01 -1.47e-01 5.57e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 10 4.20e-01 1.47e-01 6.84e-01
Cilium Assembly 187 5.30e-04 -1.47e-01 9.46e-03
Glycerophospholipid catabolism 6 5.34e-01 -1.47e-01 7.74e-01
MHC class II antigen presentation 113 7.16e-03 -1.46e-01 7.09e-02
SLC transporter disorders 75 2.83e-02 1.46e-01 1.78e-01
TYSND1 cleaves peroxisomal proteins 7 5.03e-01 1.46e-01 7.46e-01
Fatty acyl-CoA biosynthesis 35 1.34e-01 -1.46e-01 4.03e-01
Ephrin signaling 17 2.97e-01 -1.46e-01 5.95e-01
Metabolism of nucleotides 86 1.91e-02 -1.46e-01 1.37e-01
RSK activation 7 5.03e-01 -1.46e-01 7.46e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 8.33e-02 -1.46e-01 3.07e-01
Signaling by WNT 237 1.09e-04 -1.46e-01 2.61e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 1.53e-01 -1.46e-01 4.36e-01
Resolution of D-Loop Structures 35 1.35e-01 -1.46e-01 4.05e-01
STAT5 activation downstream of FLT3 ITD mutants 9 4.49e-01 1.46e-01 7.03e-01
Synthesis of PIPs at the ER membrane 5 5.73e-01 -1.45e-01 8.00e-01
RUNX2 regulates genes involved in cell migration 6 5.37e-01 1.45e-01 7.77e-01
Transcriptional Regulation by MECP2 47 8.49e-02 -1.45e-01 3.10e-01
Regulation of RUNX3 expression and activity 45 9.27e-02 -1.45e-01 3.24e-01
Defective B3GAT3 causes JDSSDHD 10 4.28e-01 1.45e-01 6.91e-01
SARS-CoV Infections 428 2.84e-07 -1.45e-01 1.19e-05
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.11e-01 -1.44e-01 5.27e-01
CHL1 interactions 8 4.80e-01 -1.44e-01 7.28e-01
Apoptosis 157 1.87e-03 -1.44e-01 2.60e-02
RAS processing 23 2.32e-01 -1.44e-01 5.50e-01
Platelet activation, signaling and aggregation 219 2.51e-04 -1.44e-01 5.43e-03
Innate Immune System 966 4.36e-14 -1.43e-01 2.40e-12
TRIF-mediated programmed cell death 9 4.57e-01 1.43e-01 7.11e-01
Mitotic Metaphase and Anaphase 211 3.44e-04 -1.43e-01 7.03e-03
Diseases of mitotic cell cycle 38 1.28e-01 -1.43e-01 3.94e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.12e-01 1.43e-01 6.79e-01
Small interfering RNA (siRNA) biogenesis 9 4.59e-01 1.43e-01 7.13e-01
M Phase 345 5.40e-06 -1.43e-01 1.85e-04
Phase I - Functionalization of compounds 62 5.26e-02 1.42e-01 2.47e-01
Ion homeostasis 40 1.19e-01 -1.42e-01 3.80e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 2.96e-01 1.42e-01 5.95e-01
Synthesis of PG 8 4.86e-01 1.42e-01 7.33e-01
Signaling by high-kinase activity BRAF mutants 33 1.58e-01 -1.42e-01 4.46e-01
Phase 0 - rapid depolarisation 23 2.38e-01 -1.42e-01 5.56e-01
IRE1alpha activates chaperones 46 9.59e-02 -1.42e-01 3.31e-01
Cytosolic iron-sulfur cluster assembly 13 3.76e-01 1.42e-01 6.66e-01
Diseases of DNA repair 50 8.28e-02 -1.42e-01 3.07e-01
Plasma lipoprotein remodeling 18 2.99e-01 -1.41e-01 5.97e-01
Netrin mediated repulsion signals 5 5.85e-01 -1.41e-01 8.06e-01
Mitotic Anaphase 210 4.35e-04 -1.41e-01 7.89e-03
Gap junction degradation 11 4.19e-01 -1.41e-01 6.84e-01
Regulation of PTEN stability and activity 55 7.10e-02 -1.41e-01 2.83e-01
Interleukin-15 signaling 14 3.63e-01 -1.41e-01 6.58e-01
Plasma lipoprotein assembly 10 4.43e-01 1.40e-01 7.03e-01
Regulated Necrosis 55 7.27e-02 -1.40e-01 2.86e-01
CRMPs in Sema3A signaling 13 3.84e-01 -1.39e-01 6.66e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 3.35e-01 -1.39e-01 6.30e-01
XBP1(S) activates chaperone genes 44 1.10e-01 -1.39e-01 3.62e-01
Amine ligand-binding receptors 10 4.46e-01 1.39e-01 7.03e-01
Tight junction interactions 17 3.22e-01 1.39e-01 6.19e-01
Serotonin Neurotransmitter Release Cycle 15 3.52e-01 -1.39e-01 6.50e-01
G alpha (s) signalling events 93 2.09e-02 -1.39e-01 1.44e-01
Processing of DNA double-strand break ends 69 4.73e-02 -1.38e-01 2.36e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 6.03e-02 -1.38e-01 2.63e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.73e-01 -1.37e-01 6.66e-01
Aquaporin-mediated transport 38 1.43e-01 -1.37e-01 4.21e-01
Regulation of NF-kappa B signaling 18 3.14e-01 -1.37e-01 6.07e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.28e-01 -1.37e-01 6.24e-01
TNFR1-induced proapoptotic signaling 24 2.47e-01 -1.37e-01 5.59e-01
Protein ubiquitination 71 4.76e-02 -1.36e-01 2.36e-01
Chondroitin sulfate biosynthesis 12 4.15e-01 1.36e-01 6.81e-01
Post NMDA receptor activation events 60 6.93e-02 -1.36e-01 2.81e-01
Pre-NOTCH Transcription and Translation 47 1.08e-01 -1.36e-01 3.57e-01
Hedgehog ‘on’ state 65 5.91e-02 -1.35e-01 2.60e-01
G beta:gamma signalling through PLC beta 17 3.35e-01 -1.35e-01 6.30e-01
Presynaptic function of Kainate receptors 17 3.35e-01 -1.35e-01 6.30e-01
Membrane Trafficking 575 3.31e-08 -1.35e-01 1.51e-06
CaM pathway 27 2.26e-01 -1.34e-01 5.42e-01
Calmodulin induced events 27 2.26e-01 -1.34e-01 5.42e-01
Leading Strand Synthesis 14 3.84e-01 -1.34e-01 6.66e-01
Polymerase switching 14 3.84e-01 -1.34e-01 6.66e-01
Transferrin endocytosis and recycling 26 2.36e-01 1.34e-01 5.53e-01
MET activates RAP1 and RAC1 10 4.63e-01 1.34e-01 7.14e-01
Cholesterol biosynthesis 26 2.37e-01 -1.34e-01 5.53e-01
Glucuronidation 8 5.12e-01 -1.34e-01 7.55e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 4.42e-01 -1.34e-01 7.02e-01
Interconversion of nucleotide di- and triphosphates 27 2.29e-01 -1.34e-01 5.44e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 1.25e-01 1.34e-01 3.90e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 4.24e-01 1.33e-01 6.86e-01
Ca-dependent events 29 2.15e-01 -1.33e-01 5.31e-01
Rap1 signalling 14 3.90e-01 -1.33e-01 6.66e-01
NRIF signals cell death from the nucleus 15 3.74e-01 1.33e-01 6.66e-01
Diseases of programmed cell death 58 8.18e-02 -1.32e-01 3.06e-01
Maturation of nucleoprotein 9694631 15 3.76e-01 -1.32e-01 6.66e-01
Signaling by NODAL 15 3.76e-01 1.32e-01 6.66e-01
Branched-chain amino acid catabolism 21 2.96e-01 -1.32e-01 5.95e-01
Cardiac conduction 88 3.27e-02 -1.32e-01 1.89e-01
Formation of the active cofactor, UDP-glucuronate 5 6.11e-01 -1.31e-01 8.25e-01
Formation of RNA Pol II elongation complex 56 8.96e-02 -1.31e-01 3.19e-01
RNA Polymerase II Transcription Elongation 56 8.96e-02 -1.31e-01 3.19e-01
Interleukin-7 signaling 21 2.98e-01 -1.31e-01 5.96e-01
Collagen biosynthesis and modifying enzymes 45 1.30e-01 -1.31e-01 3.96e-01
G2/M DNA damage checkpoint 66 6.66e-02 -1.31e-01 2.75e-01
MECP2 regulates neuronal receptors and channels 13 4.16e-01 -1.30e-01 6.82e-01
Cellular response to hypoxia 59 8.37e-02 -1.30e-01 3.07e-01
TGFBR3 expression 20 3.14e-01 -1.30e-01 6.07e-01
Immune System 1828 3.02e-20 -1.30e-01 2.41e-18
HDL remodeling 6 5.82e-01 -1.30e-01 8.04e-01
Programmed Cell Death 186 2.27e-03 -1.30e-01 3.00e-02
DNA Repair 288 1.52e-04 -1.30e-01 3.40e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.62e-01 1.30e-01 5.72e-01
Signaling by PDGFRA extracellular domain mutants 12 4.37e-01 -1.29e-01 7.00e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 4.37e-01 -1.29e-01 7.00e-01
Synthesis of PIPs at the early endosome membrane 16 3.70e-01 1.29e-01 6.65e-01
Regulation of RUNX2 expression and activity 54 1.00e-01 -1.29e-01 3.41e-01
ER-Phagosome pathway 74 5.50e-02 -1.29e-01 2.52e-01
Establishment of Sister Chromatid Cohesion 11 4.59e-01 -1.29e-01 7.13e-01
Interferon Signaling 237 6.32e-04 -1.29e-01 1.10e-02
EPHB-mediated forward signaling 38 1.70e-01 -1.29e-01 4.63e-01
Synthesis, secretion, and deacylation of Ghrelin 11 4.61e-01 -1.28e-01 7.13e-01
Triglyceride catabolism 15 3.91e-01 -1.28e-01 6.66e-01
RHOU GTPase cycle 40 1.61e-01 -1.28e-01 4.50e-01
Sulfur amino acid metabolism 22 2.99e-01 -1.28e-01 5.97e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 2.33e-01 -1.28e-01 5.50e-01
Synthesis of diphthamide-EEF2 8 5.32e-01 1.28e-01 7.73e-01
Formation of paraxial mesoderm 52 1.12e-01 -1.27e-01 3.65e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 4.09e-01 -1.27e-01 6.77e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 4.09e-01 -1.27e-01 6.77e-01
Signaling by FLT3 ITD and TKD mutants 15 3.93e-01 1.27e-01 6.67e-01
Pyroptosis 24 2.80e-01 -1.27e-01 5.84e-01
Pre-NOTCH Processing in Golgi 18 3.51e-01 -1.27e-01 6.50e-01
HSF1-dependent transactivation 28 2.45e-01 -1.27e-01 5.59e-01
Cytosolic tRNA aminoacylation 24 2.82e-01 -1.27e-01 5.85e-01
G alpha (z) signalling events 36 1.88e-01 -1.27e-01 4.94e-01
Cell-Cell communication 108 2.30e-02 -1.27e-01 1.53e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 3.16e-01 -1.26e-01 6.10e-01
MAP2K and MAPK activation 36 1.90e-01 -1.26e-01 4.97e-01
Response of Mtb to phagocytosis 22 3.07e-01 -1.26e-01 6.03e-01
RUNX3 regulates CDKN1A transcription 7 5.65e-01 1.26e-01 7.97e-01
RMTs methylate histone arginines 35 1.99e-01 -1.25e-01 5.10e-01
Integrin signaling 22 3.08e-01 -1.25e-01 6.04e-01
Amyloid fiber formation 51 1.21e-01 -1.25e-01 3.83e-01
Regulation of FZD by ubiquitination 15 4.02e-01 -1.25e-01 6.71e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.72e-01 -1.25e-01 6.65e-01
MAP kinase activation 63 8.66e-02 1.25e-01 3.14e-01
Phospholipase C-mediated cascade; FGFR2 8 5.43e-01 -1.24e-01 7.79e-01
Metabolism of water-soluble vitamins and cofactors 114 2.19e-02 -1.24e-01 1.48e-01
HDR through Homologous Recombination (HRR) 68 7.69e-02 -1.24e-01 2.97e-01
Neutrophil degranulation 456 5.89e-06 -1.24e-01 1.98e-04
Infectious disease 951 1.17e-10 -1.23e-01 5.93e-09
Translesion synthesis by POLK 17 3.79e-01 -1.23e-01 6.66e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 1.19e-01 -1.23e-01 3.80e-01
SHC1 events in ERBB2 signaling 17 3.81e-01 1.23e-01 6.66e-01
PI3K/AKT activation 8 5.49e-01 1.22e-01 7.84e-01
Notch-HLH transcription pathway 28 2.62e-01 1.22e-01 5.72e-01
Depolymerization of the Nuclear Lamina 15 4.13e-01 -1.22e-01 6.79e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 2.63e-01 -1.22e-01 5.73e-01
Viral Infection Pathways 770 8.13e-09 -1.22e-01 3.91e-07
Sialic acid metabolism 27 2.72e-01 -1.22e-01 5.78e-01
Glycosphingolipid catabolism 31 2.40e-01 1.22e-01 5.57e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 6.05e-01 -1.22e-01 8.23e-01
Inactivation of CSF3 (G-CSF) signaling 24 3.02e-01 -1.22e-01 5.98e-01
Inactivation of CDC42 and RAC1 7 5.78e-01 1.22e-01 8.03e-01
Anchoring of the basal body to the plasma membrane 97 3.86e-02 -1.22e-01 2.13e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 4.00e-01 1.21e-01 6.70e-01
Regulation of TP53 Activity through Acetylation 29 2.58e-01 -1.21e-01 5.70e-01
Interleukin-17 signaling 68 8.44e-02 1.21e-01 3.09e-01
CREB3 factors activate genes 6 6.08e-01 -1.21e-01 8.25e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 3.90e-01 -1.20e-01 6.66e-01
Inositol phosphate metabolism 42 1.77e-01 -1.20e-01 4.76e-01
VEGFA-VEGFR2 Pathway 93 4.49e-02 -1.20e-01 2.29e-01
Mitotic Spindle Checkpoint 107 3.15e-02 -1.20e-01 1.85e-01
Signaling by Hedgehog 120 2.31e-02 -1.20e-01 1.53e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 3.80e-02 1.20e-01 2.12e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 3.09e-01 -1.20e-01 6.04e-01
MET activates RAS signaling 10 5.12e-01 -1.20e-01 7.55e-01
Class B/2 (Secretin family receptors) 54 1.28e-01 -1.20e-01 3.94e-01
UCH proteinases 73 7.79e-02 -1.19e-01 2.99e-01
Nephrin family interactions 19 3.68e-01 -1.19e-01 6.62e-01
FGFR2 mutant receptor activation 23 3.23e-01 -1.19e-01 6.19e-01
Regulation of gene expression in beta cells 7 5.85e-01 -1.19e-01 8.06e-01
tRNA processing 128 2.01e-02 1.19e-01 1.40e-01
Asymmetric localization of PCP proteins 49 1.51e-01 -1.19e-01 4.32e-01
APC-Cdc20 mediated degradation of Nek2A 26 2.96e-01 -1.18e-01 5.95e-01
Lewis blood group biosynthesis 13 4.61e-01 -1.18e-01 7.13e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 4.45e-01 1.18e-01 7.03e-01
Cell junction organization 77 7.41e-02 -1.18e-01 2.89e-01
Estrogen biosynthesis 5 6.49e-01 1.17e-01 8.47e-01
ABC transporter disorders 59 1.20e-01 -1.17e-01 3.81e-01
Negative feedback regulation of MAPK pathway 6 6.20e-01 1.17e-01 8.32e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 2.95e-01 -1.16e-01 5.95e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 2.95e-01 -1.16e-01 5.95e-01
Iron uptake and transport 52 1.46e-01 1.16e-01 4.25e-01
Diseases associated with O-glycosylation of proteins 46 1.73e-01 -1.16e-01 4.68e-01
Phospholipase C-mediated cascade; FGFR4 6 6.23e-01 -1.16e-01 8.32e-01
Estrogen-dependent gene expression 96 4.96e-02 -1.16e-01 2.40e-01
Deadenylation of mRNA 22 3.47e-01 1.16e-01 6.45e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 4.69e-01 1.16e-01 7.20e-01
MAPK1 (ERK2) activation 8 5.71e-01 -1.16e-01 7.99e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 4.88e-01 -1.16e-01 7.34e-01
Signaling by RNF43 mutants 7 5.96e-01 -1.16e-01 8.18e-01
Defensins 8 5.71e-01 -1.16e-01 7.99e-01
RHOBTB2 GTPase cycle 23 3.37e-01 -1.16e-01 6.32e-01
RIP-mediated NFkB activation via ZBP1 17 4.09e-01 1.16e-01 6.77e-01
Zygotic genome activation (ZGA) 5 6.55e-01 1.16e-01 8.51e-01
Apoptosis induced DNA fragmentation 10 5.28e-01 -1.15e-01 7.70e-01
Wax and plasmalogen biosynthesis 5 6.55e-01 1.15e-01 8.51e-01
RSV-host interactions 76 8.28e-02 -1.15e-01 3.07e-01
Late endosomal microautophagy 30 2.77e-01 -1.15e-01 5.83e-01
LDL clearance 18 4.00e-01 1.15e-01 6.70e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 6.57e-01 1.15e-01 8.52e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 6.57e-01 1.15e-01 8.52e-01
Muscle contraction 142 1.90e-02 -1.14e-01 1.37e-01
Mitotic Telophase/Cytokinesis 13 4.77e-01 -1.14e-01 7.28e-01
Toll Like Receptor 9 (TLR9) Cascade 108 4.09e-02 1.14e-01 2.18e-01
LGI-ADAM interactions 9 5.55e-01 -1.14e-01 7.89e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 3.80e-01 -1.13e-01 6.66e-01
SIRT1 negatively regulates rRNA expression 22 3.57e-01 -1.13e-01 6.56e-01
Insulin receptor recycling 24 3.37e-01 1.13e-01 6.32e-01
Acyl chain remodelling of PE 19 3.93e-01 1.13e-01 6.67e-01
Uptake and function of anthrax toxins 10 5.37e-01 -1.13e-01 7.76e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 6.62e-01 -1.13e-01 8.54e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 2.19e-01 -1.12e-01 5.36e-01
Signaling by RAS mutants 40 2.19e-01 -1.12e-01 5.36e-01
Signaling by moderate kinase activity BRAF mutants 40 2.19e-01 -1.12e-01 5.36e-01
Signaling downstream of RAS mutants 40 2.19e-01 -1.12e-01 5.36e-01
Signaling by SCF-KIT 40 2.20e-01 -1.12e-01 5.37e-01
Estrogen-stimulated signaling through PRKCZ 6 6.35e-01 -1.12e-01 8.40e-01
Activation of GABAB receptors 29 2.97e-01 -1.12e-01 5.96e-01
GABA B receptor activation 29 2.97e-01 -1.12e-01 5.96e-01
PI-3K cascade:FGFR2 13 4.85e-01 1.12e-01 7.32e-01
Recognition of DNA damage by PCNA-containing replication complex 30 2.89e-01 -1.12e-01 5.92e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 4.39e-01 1.12e-01 7.00e-01
NIK–>noncanonical NF-kB signaling 46 1.90e-01 -1.12e-01 4.97e-01
Suppression of apoptosis 7 6.09e-01 -1.12e-01 8.25e-01
G beta:gamma signalling through PI3Kgamma 22 3.66e-01 -1.11e-01 6.61e-01
Miscellaneous transport and binding events 20 3.89e-01 -1.11e-01 6.66e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.30e-01 -1.11e-01 3.96e-01
Signaling by VEGF 100 5.48e-02 -1.11e-01 2.52e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.93e-01 1.11e-01 5.93e-01
Maturation of hRSV A proteins 13 4.89e-01 1.11e-01 7.34e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 2.50e-01 -1.11e-01 5.63e-01
Mitochondrial translation initiation 90 6.94e-02 -1.11e-01 2.81e-01
Downregulation of ERBB2:ERBB3 signaling 12 5.07e-01 -1.11e-01 7.50e-01
MAPK1/MAPK3 signaling 227 4.06e-03 -1.11e-01 4.60e-02
Signaling by RAF1 mutants 36 2.52e-01 -1.10e-01 5.64e-01
Oxidative Stress Induced Senescence 77 9.54e-02 -1.10e-01 3.31e-01
MyD88 dependent cascade initiated on endosome 101 5.64e-02 1.10e-01 2.54e-01
Keratan sulfate/keratin metabolism 27 3.24e-01 -1.10e-01 6.20e-01
Regulation of localization of FOXO transcription factors 11 5.29e-01 1.10e-01 7.71e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 4.21e-01 1.10e-01 6.84e-01
Nonhomologous End-Joining (NHEJ) 40 2.31e-01 -1.09e-01 5.47e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.95e-01 -1.09e-01 7.41e-01
Infection with Mycobacterium tuberculosis 26 3.34e-01 -1.09e-01 6.30e-01
Chondroitin sulfate/dermatan sulfate metabolism 37 2.50e-01 1.09e-01 5.63e-01
Pentose phosphate pathway 13 4.96e-01 -1.09e-01 7.41e-01
Aggrephagy 34 2.71e-01 -1.09e-01 5.78e-01
Carboxyterminal post-translational modifications of tubulin 33 2.78e-01 -1.09e-01 5.83e-01
Beta-oxidation of pristanoyl-CoA 9 5.71e-01 -1.09e-01 7.99e-01
Digestion 5 6.74e-01 1.09e-01 8.59e-01
Biosynthesis of EPA-derived SPMs 6 6.45e-01 1.09e-01 8.47e-01
Ethanol oxidation 6 6.45e-01 1.09e-01 8.47e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 2.61e-01 -1.08e-01 5.72e-01
Regulation of pyruvate metabolism 32 2.90e-01 -1.08e-01 5.92e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 5.59e-02 1.08e-01 2.53e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 6.76e-01 -1.08e-01 8.61e-01
Association of TriC/CCT with target proteins during biosynthesis 35 2.70e-01 -1.08e-01 5.78e-01
Drug ADME 55 1.68e-01 -1.08e-01 4.61e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 3.53e-01 1.07e-01 6.51e-01
Suppression of phagosomal maturation 12 5.20e-01 -1.07e-01 7.65e-01
RND2 GTPase cycle 36 2.67e-01 -1.07e-01 5.77e-01
RNA Polymerase II Pre-transcription Events 77 1.05e-01 -1.07e-01 3.52e-01
Signaling by PDGF 48 2.01e-01 -1.07e-01 5.10e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.66e-01 -1.06e-01 6.61e-01
Sodium/Calcium exchangers 9 5.80e-01 -1.06e-01 8.04e-01
Interferon gamma signaling 87 8.63e-02 -1.06e-01 3.13e-01
Neurotoxicity of clostridium toxins 9 5.81e-01 1.06e-01 8.04e-01
RAF/MAP kinase cascade 222 6.34e-03 -1.06e-01 6.48e-02
Visual phototransduction 58 1.62e-01 -1.06e-01 4.50e-01
Activation of HOX genes during differentiation 68 1.31e-01 -1.06e-01 3.96e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 1.31e-01 -1.06e-01 3.96e-01
Recycling of bile acids and salts 8 6.04e-01 1.06e-01 8.23e-01
Adenylate cyclase activating pathway 8 6.04e-01 1.06e-01 8.23e-01
ABC-family proteins mediated transport 81 9.95e-02 -1.06e-01 3.41e-01
Metabolism of amino acids and derivatives 304 1.51e-03 -1.06e-01 2.23e-02
Intrinsic Pathway for Apoptosis 53 1.83e-01 -1.06e-01 4.87e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 4.38e-01 -1.06e-01 7.00e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 4.38e-01 -1.06e-01 7.00e-01
Senescence-Associated Secretory Phenotype (SASP) 64 1.44e-01 -1.05e-01 4.23e-01
Integrin cell surface interactions 64 1.45e-01 -1.05e-01 4.23e-01
Antigen processing-Cross presentation 88 8.82e-02 -1.05e-01 3.16e-01
Signaling by MST1 5 6.84e-01 -1.05e-01 8.65e-01
RORA activates gene expression 18 4.40e-01 1.05e-01 7.01e-01
Downstream signaling events of B Cell Receptor (BCR) 68 1.34e-01 -1.05e-01 4.02e-01
Signaling by ERBB2 KD Mutants 20 4.17e-01 1.05e-01 6.83e-01
Regulation of TP53 Degradation 35 2.83e-01 -1.05e-01 5.85e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 4.82e-01 -1.05e-01 7.28e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 4.82e-01 -1.05e-01 7.28e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 4.82e-01 -1.05e-01 7.28e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 4.82e-01 -1.05e-01 7.28e-01
Signaling by CTNNB1 phospho-site mutants 15 4.82e-01 -1.05e-01 7.28e-01
Signaling by GSK3beta mutants 15 4.82e-01 -1.05e-01 7.28e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 6.32e-01 -1.04e-01 8.39e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.78e-01 1.04e-01 5.83e-01
Beta-catenin independent WNT signaling 124 4.50e-02 -1.04e-01 2.29e-01
NFE2L2 regulates pentose phosphate pathway genes 8 6.10e-01 1.04e-01 8.25e-01
RHOC GTPase cycle 71 1.30e-01 -1.04e-01 3.96e-01
MyD88 cascade initiated on plasma membrane 95 8.03e-02 1.04e-01 3.03e-01
Toll Like Receptor 10 (TLR10) Cascade 95 8.03e-02 1.04e-01 3.03e-01
Toll Like Receptor 5 (TLR5) Cascade 95 8.03e-02 1.04e-01 3.03e-01
MAPK family signaling cascades 259 4.18e-03 -1.03e-01 4.60e-02
Regulation of TNFR1 signaling 47 2.22e-01 -1.03e-01 5.39e-01
Organelle biogenesis and maintenance 278 3.16e-03 -1.03e-01 3.77e-02
Pre-NOTCH Expression and Processing 63 1.58e-01 -1.03e-01 4.46e-01
Triglyceride metabolism 24 3.84e-01 -1.03e-01 6.66e-01
Prolactin receptor signaling 11 5.57e-01 -1.02e-01 7.90e-01
FOXO-mediated transcription 57 1.82e-01 1.02e-01 4.87e-01
PCP/CE pathway 74 1.29e-01 -1.02e-01 3.96e-01
EGFR downregulation 26 3.68e-01 1.02e-01 6.62e-01
Dectin-1 mediated noncanonical NF-kB signaling 47 2.27e-01 -1.02e-01 5.42e-01
2-LTR circle formation 7 6.41e-01 -1.02e-01 8.45e-01
Synthesis of PC 23 4.00e-01 1.01e-01 6.70e-01
RUNX2 regulates bone development 21 4.22e-01 -1.01e-01 6.84e-01
Nuclear signaling by ERBB4 24 3.90e-01 1.01e-01 6.66e-01
Erythropoietin activates STAT5 6 6.68e-01 1.01e-01 8.56e-01
Metabolism of steroid hormones 21 4.22e-01 1.01e-01 6.84e-01
Homologous DNA Pairing and Strand Exchange 43 2.51e-01 -1.01e-01 5.63e-01
Glutathione conjugation 26 3.74e-01 -1.01e-01 6.66e-01
Signaling by ERBB2 in Cancer 21 4.26e-01 1.00e-01 6.88e-01
Activation of the phototransduction cascade 8 6.23e-01 1.00e-01 8.32e-01
Collagen chain trimerization 26 3.77e-01 -1.00e-01 6.66e-01
Diseases associated with glycosaminoglycan metabolism 24 3.96e-01 1.00e-01 6.67e-01
Apoptotic factor-mediated response 19 4.51e-01 -9.99e-02 7.04e-01
Signaling by Leptin 10 5.84e-01 9.99e-02 8.06e-01
Lysosome Vesicle Biogenesis 32 3.29e-01 -9.98e-02 6.24e-01
Ion transport by P-type ATPases 41 2.69e-01 -9.97e-02 5.78e-01
Alpha-protein kinase 1 signaling pathway 11 5.67e-01 9.97e-02 7.97e-01
Signaling by WNT in cancer 30 3.46e-01 -9.95e-02 6.44e-01
Frs2-mediated activation 11 5.69e-01 -9.93e-02 7.98e-01
Antiviral mechanism by IFN-stimulated genes 140 4.28e-02 -9.92e-02 2.23e-01
Signaling by CSF3 (G-CSF) 29 3.56e-01 -9.91e-02 6.53e-01
Regulation of TP53 Activity through Methylation 19 4.55e-01 -9.90e-02 7.09e-01
Formation of the Early Elongation Complex 33 3.27e-01 -9.85e-02 6.23e-01
Formation of the HIV-1 Early Elongation Complex 33 3.27e-01 -9.85e-02 6.23e-01
Glycogen storage diseases 13 5.39e-01 -9.85e-02 7.77e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 6.52e-01 -9.83e-02 8.49e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 6.30e-01 9.83e-02 8.37e-01
Translesion synthesis by POLI 17 4.83e-01 -9.82e-02 7.29e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 4.49e-01 9.78e-02 7.03e-01
Regulation of signaling by NODAL 6 6.79e-01 9.76e-02 8.63e-01
Cytoprotection by HMOX1 53 2.21e-01 9.72e-02 5.37e-01
CD28 co-stimulation 33 3.35e-01 -9.69e-02 6.30e-01
Signaling by FLT3 fusion proteins 18 4.77e-01 9.69e-02 7.28e-01
Detoxification of Reactive Oxygen Species 30 3.60e-01 -9.65e-02 6.58e-01
Metabolism of amine-derived hormones 10 5.97e-01 -9.65e-02 8.19e-01
Signal amplification 28 3.77e-01 -9.64e-02 6.66e-01
Cellular Senescence 142 4.76e-02 -9.63e-02 2.36e-01
Signaling by FGFR4 in disease 11 5.80e-01 9.63e-02 8.04e-01
Signal transduction by L1 20 4.57e-01 -9.62e-02 7.11e-01
TNFR1-induced NF-kappa-B signaling pathway 32 3.47e-01 -9.61e-02 6.45e-01
TGF-beta receptor signaling activates SMADs 45 2.65e-01 -9.60e-02 5.75e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 6.62e-01 9.55e-02 8.54e-01
TGFBR3 PTM regulation 10 6.02e-01 9.52e-02 8.21e-01
Signaling by FGFR1 in disease 32 3.51e-01 9.52e-02 6.50e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.00e-01 -9.49e-02 5.10e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 6.23e-01 9.48e-02 8.32e-01
O-linked glycosylation 81 1.41e-01 -9.46e-02 4.17e-01
EPH-ephrin mediated repulsion of cells 42 2.89e-01 -9.45e-02 5.92e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 5.27e-01 -9.42e-02 7.70e-01
Peroxisomal protein import 58 2.15e-01 -9.42e-02 5.31e-01
TRAF6 mediated IRF7 activation 15 5.29e-01 -9.39e-02 7.71e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 3.04e-01 -9.39e-02 5.99e-01
Amino acids regulate mTORC1 48 2.62e-01 9.37e-02 5.72e-01
mRNA Splicing - Minor Pathway 50 2.52e-01 -9.36e-02 5.64e-01
ZBP1(DAI) mediated induction of type I IFNs 20 4.70e-01 9.33e-02 7.20e-01
Signaling by activated point mutants of FGFR1 5 7.18e-01 9.32e-02 8.84e-01
Retrograde transport at the Trans-Golgi-Network 49 2.60e-01 -9.30e-02 5.72e-01
Biological oxidations 135 6.22e-02 9.30e-02 2.66e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 9 6.30e-01 9.28e-02 8.37e-01
Defective EXT2 causes exostoses 2 9 6.30e-01 9.28e-02 8.37e-01
Maturation of spike protein 9683686 5 7.21e-01 9.24e-02 8.84e-01
Inflammasomes 21 4.64e-01 9.22e-02 7.16e-01
Transcriptional regulation of pluripotent stem cells 18 5.00e-01 -9.19e-02 7.45e-01
Physiological factors 9 6.34e-01 9.17e-02 8.39e-01
Disease 1606 1.00e-09 -9.15e-02 4.95e-08
Reproduction 84 1.47e-01 -9.14e-02 4.27e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 7.23e-01 9.14e-02 8.84e-01
Maple Syrup Urine Disease 5 7.23e-01 9.14e-02 8.84e-01
Cohesin Loading onto Chromatin 10 6.17e-01 9.13e-02 8.29e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 5.41e-01 -9.11e-02 7.79e-01
Striated Muscle Contraction 25 4.32e-01 -9.08e-02 6.94e-01
Recycling pathway of L1 40 3.21e-01 -9.07e-02 6.17e-01
FasL/ CD95L signaling 5 7.26e-01 -9.06e-02 8.86e-01
Synthesis of Dolichyl-phosphate 6 7.02e-01 -9.03e-02 8.77e-01
FGFR2c ligand binding and activation 5 7.27e-01 9.01e-02 8.86e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 78 1.69e-01 -9.01e-02 4.62e-01
SUMOylation of chromatin organization proteins 57 2.41e-01 8.99e-02 5.57e-01
Prolonged ERK activation events 13 5.77e-01 -8.95e-02 8.03e-01
DNA replication initiation 8 6.61e-01 -8.94e-02 8.54e-01
Mitochondrial unfolded protein response (UPRmt) 17 5.23e-01 8.94e-02 7.68e-01
HIV Transcription Initiation 45 3.01e-01 -8.91e-02 5.97e-01
RNA Polymerase II HIV Promoter Escape 45 3.01e-01 -8.91e-02 5.97e-01
RNA Polymerase II Promoter Escape 45 3.01e-01 -8.91e-02 5.97e-01
RNA Polymerase II Transcription Initiation 45 3.01e-01 -8.91e-02 5.97e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 3.01e-01 -8.91e-02 5.97e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 3.01e-01 -8.91e-02 5.97e-01
Formation of Incision Complex in GG-NER 43 3.13e-01 8.90e-02 6.07e-01
Synthesis of substrates in N-glycan biosythesis 58 2.42e-01 -8.89e-02 5.57e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 5.39e-01 -8.86e-02 7.78e-01
Mitochondrial translation elongation 90 1.46e-01 -8.86e-02 4.25e-01
Transcriptional Regulation by E2F6 34 3.71e-01 -8.86e-02 6.65e-01
Recycling of eIF2:GDP 8 6.65e-01 -8.85e-02 8.56e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 5.67e-01 -8.84e-02 7.97e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.57e-01 -8.84e-02 5.68e-01
Rab regulation of trafficking 122 9.19e-02 -8.83e-02 3.23e-01
RHOT1 GTPase cycle 5 7.32e-01 8.83e-02 8.89e-01
Dual incision in TC-NER 63 2.26e-01 -8.83e-02 5.42e-01
Fatty acid metabolism 152 6.05e-02 -8.82e-02 2.64e-01
mRNA 3’-end processing 57 2.50e-01 8.82e-02 5.63e-01
GPVI-mediated activation cascade 31 3.97e-01 -8.79e-02 6.67e-01
Blood group systems biosynthesis 16 5.45e-01 -8.74e-02 7.81e-01
IRF3-mediated induction of type I IFN 12 6.00e-01 8.74e-02 8.21e-01
HDMs demethylate histones 22 4.78e-01 8.74e-02 7.28e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 5.46e-01 8.72e-02 7.81e-01
Mitochondrial translation termination 90 1.53e-01 -8.71e-02 4.36e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 4.34e-01 -8.70e-02 6.96e-01
RNA Polymerase I Transcription Termination 30 4.10e-01 8.69e-02 6.77e-01
Alpha-oxidation of phytanate 6 7.12e-01 8.69e-02 8.84e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 5.60e-01 -8.68e-02 7.95e-01
Transcriptional regulation by RUNX2 87 1.62e-01 -8.67e-02 4.50e-01
RUNX1 regulates expression of components of tight junctions 5 7.37e-01 8.66e-02 8.92e-01
CD209 (DC-SIGN) signaling 20 5.05e-01 8.61e-02 7.48e-01
Nuclear events mediated by NFE2L2 81 1.80e-01 -8.61e-02 4.83e-01
DAP12 signaling 28 4.31e-01 -8.60e-02 6.94e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 2.80e-01 8.59e-02 5.83e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 2.80e-01 8.59e-02 5.83e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 2.80e-01 8.59e-02 5.83e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 2.80e-01 8.59e-02 5.83e-01
Signaling by NOTCH1 in Cancer 53 2.80e-01 8.59e-02 5.83e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 2.73e-04 -8.57e-02 5.77e-03
RNA Polymerase II Transcription Termination 66 2.29e-01 8.56e-02 5.44e-01
DAG and IP3 signaling 33 3.96e-01 -8.53e-02 6.67e-01
Signaling by Rho GTPases 603 3.54e-04 -8.52e-02 7.09e-03
Collagen formation 63 2.42e-01 -8.52e-02 5.57e-01
Insulin processing 19 5.22e-01 -8.48e-02 7.67e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 107 1.32e-01 8.44e-02 3.99e-01
PTEN Regulation 126 1.02e-01 -8.43e-02 3.47e-01
Transport of vitamins, nucleosides, and related molecules 31 4.18e-01 8.41e-02 6.83e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 4.50e-01 -8.40e-02 7.03e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 60 2.61e-01 -8.38e-02 5.72e-01
VEGFR2 mediated cell proliferation 18 5.38e-01 -8.38e-02 7.77e-01
Semaphorin interactions 56 2.81e-01 -8.33e-02 5.84e-01
Crosslinking of collagen fibrils 12 6.18e-01 8.32e-02 8.29e-01
Viral Messenger RNA Synthesis 44 3.40e-01 8.32e-02 6.34e-01
SARS-CoV-1 activates/modulates innate immune responses 40 3.63e-01 -8.32e-02 6.58e-01
Neddylation 215 3.56e-02 -8.31e-02 2.02e-01
Spry regulation of FGF signaling 16 5.66e-01 -8.29e-02 7.97e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 2.45e-01 -8.28e-02 5.59e-01
Regulation of insulin secretion 62 2.60e-01 -8.27e-02 5.72e-01
Mitochondrial Uncoupling 6 7.26e-01 8.25e-02 8.86e-01
Metabolism of folate and pterines 16 5.68e-01 -8.24e-02 7.98e-01
Signaling by NOTCH 173 6.22e-02 -8.22e-02 2.66e-01
Passive transport by Aquaporins 6 7.28e-01 8.19e-02 8.87e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 3.65e-01 -8.18e-02 6.60e-01
Diseases of DNA Double-Strand Break Repair 41 3.65e-01 -8.18e-02 6.60e-01
Regulation of TP53 Activity through Association with Co-factors 11 6.39e-01 8.17e-02 8.43e-01
Prevention of phagosomal-lysosomal fusion 9 6.71e-01 -8.16e-02 8.59e-01
FGFRL1 modulation of FGFR1 signaling 7 7.09e-01 -8.14e-02 8.82e-01
Metabolism of vitamins and cofactors 163 7.30e-02 -8.14e-02 2.86e-01
Peroxisomal lipid metabolism 27 4.64e-01 -8.14e-02 7.16e-01
Cytokine Signaling in Immune system 662 3.59e-04 -8.14e-02 7.10e-03
SUMOylation of immune response proteins 12 6.26e-01 8.13e-02 8.35e-01
Interleukin-35 Signalling 12 6.26e-01 -8.12e-02 8.35e-01
G alpha (i) signalling events 196 5.05e-02 -8.10e-02 2.42e-01
Respiratory Syncytial Virus Infection Pathway 97 1.69e-01 -8.08e-02 4.62e-01
Signaling by EGFR 47 3.39e-01 8.06e-02 6.34e-01
ESR-mediated signaling 157 8.40e-02 -7.99e-02 3.08e-01
Extracellular matrix organization 213 4.45e-02 -7.99e-02 2.29e-01
Downregulation of TGF-beta receptor signaling 26 4.81e-01 7.99e-02 7.28e-01
Signaling by ERBB4 45 3.54e-01 7.99e-02 6.51e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.71e-01 -7.98e-02 6.65e-01
HIV Transcription Elongation 42 3.71e-01 -7.98e-02 6.65e-01
Tat-mediated elongation of the HIV-1 transcript 42 3.71e-01 -7.98e-02 6.65e-01
CDC6 association with the ORC:origin complex 8 6.96e-01 -7.97e-02 8.73e-01
NoRC negatively regulates rRNA expression 60 2.86e-01 -7.96e-02 5.90e-01
Amino acid transport across the plasma membrane 24 5.00e-01 -7.96e-02 7.45e-01
Signaling by NOTCH2 33 4.30e-01 7.94e-02 6.93e-01
PINK1-PRKN Mediated Mitophagy 31 4.44e-01 -7.94e-02 7.03e-01
Signaling by TGFBR3 39 3.92e-01 -7.93e-02 6.66e-01
Attachment of GPI anchor to uPAR 7 7.17e-01 -7.91e-02 8.84e-01
EPH-Ephrin signaling 79 2.25e-01 -7.89e-02 5.42e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 5.13e-01 -7.89e-02 7.56e-01
Metabolism of steroids 120 1.36e-01 -7.88e-02 4.05e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 3.82e-01 7.88e-02 6.66e-01
Fanconi Anemia Pathway 36 4.13e-01 -7.88e-02 6.79e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.50e-01 7.85e-02 7.03e-01
Peptide hormone metabolism 53 3.25e-01 -7.81e-02 6.22e-01
Acyl chain remodelling of PC 19 5.56e-01 -7.81e-02 7.90e-01
Mitophagy 38 4.06e-01 -7.79e-02 6.75e-01
Post-transcriptional silencing by small RNAs 7 7.21e-01 -7.79e-02 8.84e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 5.49e-01 7.74e-02 7.84e-01
Downstream signaling of activated FGFR3 17 5.81e-01 7.72e-02 8.04e-01
Regulation of TP53 Expression and Degradation 36 4.24e-01 -7.70e-02 6.86e-01
Negative epigenetic regulation of rRNA expression 63 2.92e-01 -7.68e-02 5.92e-01
Listeria monocytogenes entry into host cells 17 5.85e-01 7.66e-02 8.06e-01
Protein localization 157 9.87e-02 -7.64e-02 3.39e-01
NCAM1 interactions 26 5.01e-01 7.62e-02 7.45e-01
Generic Transcription Pathway 1067 2.73e-05 -7.61e-02 8.08e-04
PDH complex synthesizes acetyl-CoA from PYR 5 7.68e-01 -7.60e-02 9.11e-01
Miro GTPase Cycle 8 7.10e-01 7.60e-02 8.82e-01
Voltage gated Potassium channels 26 5.03e-01 7.59e-02 7.46e-01
FLT3 Signaling 38 4.19e-01 -7.58e-02 6.84e-01
Neurofascin interactions 5 7.69e-01 -7.58e-02 9.12e-01
Regulation of TP53 Activity through Phosphorylation 88 2.20e-01 -7.57e-02 5.37e-01
Signaling by NOTCH1 66 2.88e-01 7.57e-02 5.92e-01
Synthesis of PA 31 4.66e-01 -7.56e-02 7.17e-01
HIV Infection 213 5.82e-02 -7.53e-02 2.58e-01
Selective autophagy 77 2.54e-01 -7.52e-02 5.64e-01
Peptide ligand-binding receptors 100 1.94e-01 7.52e-02 5.02e-01
MITF-M-dependent gene expression 81 2.43e-01 -7.51e-02 5.57e-01
Regulation of beta-cell development 21 5.53e-01 7.49e-02 7.87e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 5.45e-01 -7.46e-02 7.81e-01
PERK regulates gene expression 30 4.80e-01 7.45e-02 7.28e-01
Metabolism of proteins 1761 2.22e-07 -7.44e-02 9.48e-06
Complex IV assembly 45 3.89e-01 7.42e-02 6.66e-01
RUNX3 regulates p14-ARF 10 6.85e-01 -7.40e-02 8.65e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 6.86e-01 -7.38e-02 8.65e-01
FRS-mediated FGFR3 signaling 12 6.58e-01 7.38e-02 8.53e-01
WNT5A-dependent internalization of FZD4 13 6.47e-01 -7.33e-02 8.47e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 5.10e-01 -7.33e-02 7.54e-01
Syndecan interactions 23 5.43e-01 7.32e-02 7.80e-01
CaMK IV-mediated phosphorylation of CREB 8 7.20e-01 -7.32e-02 8.84e-01
Erythropoietin activates RAS 13 6.48e-01 -7.31e-02 8.47e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 5.27e-01 -7.30e-02 7.70e-01
Cardiogenesis 13 6.49e-01 -7.30e-02 8.47e-01
Protein methylation 15 6.25e-01 -7.29e-02 8.34e-01
Mitochondrial translation 96 2.18e-01 -7.28e-02 5.36e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 3.78e-01 7.28e-02 6.66e-01
Ub-specific processing proteases 153 1.22e-01 -7.25e-02 3.83e-01
TNF signaling 56 3.51e-01 -7.20e-02 6.50e-01
Nectin/Necl trans heterodimerization 5 7.81e-01 7.19e-02 9.18e-01
FGFR1 mutant receptor activation 25 5.35e-01 7.17e-02 7.75e-01
Metal ion SLC transporters 19 5.89e-01 7.17e-02 8.10e-01
Activated point mutants of FGFR2 7 7.43e-01 -7.16e-02 8.97e-01
Phosphorylation of the APC/C 20 5.81e-01 -7.13e-02 8.04e-01
Diseases associated with N-glycosylation of proteins 20 5.82e-01 7.11e-02 8.04e-01
G alpha (12/13) signalling events 68 3.12e-01 -7.09e-02 6.07e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 7.64e-01 7.09e-02 9.07e-01
Collagen degradation 41 4.33e-01 7.07e-02 6.96e-01
MET promotes cell motility 32 4.90e-01 7.05e-02 7.36e-01
Stimuli-sensing channels 78 2.84e-01 7.02e-02 5.86e-01
RNA Polymerase II Transcription 1185 5.02e-05 -7.00e-02 1.31e-03
MyD88 deficiency (TLR2/4) 14 6.51e-01 -6.99e-02 8.48e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 6.40e-01 6.98e-02 8.43e-01
Post-translational protein modification 1232 3.86e-05 -6.97e-02 1.09e-03
Antigen processing: Ubiquitination & Proteasome degradation 275 4.74e-02 -6.95e-02 2.36e-01
Josephin domain DUBs 10 7.05e-01 -6.90e-02 8.79e-01
Phenylalanine and tyrosine metabolism 9 7.21e-01 -6.87e-02 8.84e-01
Ribosomal scanning and start codon recognition 58 3.66e-01 6.86e-02 6.61e-01
Norepinephrine Neurotransmitter Release Cycle 14 6.58e-01 6.84e-02 8.52e-01
Signaling by NOTCH3 42 4.44e-01 -6.82e-02 7.03e-01
Heparan sulfate/heparin (HS-GAG) metabolism 39 4.61e-01 6.82e-02 7.13e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 6.59e-01 6.82e-02 8.53e-01
Class I MHC mediated antigen processing & presentation 343 3.02e-02 -6.81e-02 1.81e-01
Intra-Golgi traffic 43 4.40e-01 6.81e-02 7.01e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 5.66e-01 6.77e-02 7.97e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.74e-01 -6.75e-02 8.59e-01
Formation of TC-NER Pre-Incision Complex 51 4.06e-01 -6.73e-02 6.75e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.72e-01 6.72e-02 6.65e-01
Sema4D induced cell migration and growth-cone collapse 19 6.12e-01 -6.71e-02 8.25e-01
A tetrasaccharide linker sequence is required for GAG synthesis 16 6.42e-01 6.71e-02 8.45e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 3.86e-01 6.70e-02 6.66e-01
Interleukin-12 signaling 44 4.42e-01 -6.70e-02 7.02e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 10 7.14e-01 6.69e-02 8.84e-01
Nicotinamide salvaging 15 6.54e-01 6.69e-02 8.51e-01
ROS and RNS production in phagocytes 30 5.26e-01 -6.68e-02 7.70e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 2.90e-01 -6.65e-02 5.92e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 2.90e-01 -6.65e-02 5.92e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 2.90e-01 -6.65e-02 5.92e-01
Regulation of NFE2L2 gene expression 8 7.46e-01 6.61e-02 9.00e-01
Ca2+ pathway 57 3.89e-01 -6.60e-02 6.66e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 6.01e-01 -6.58e-02 8.21e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 6.01e-01 -6.58e-02 8.21e-01
Defects in biotin (Btn) metabolism 8 7.47e-01 -6.58e-02 9.00e-01
SARS-CoV-1 Infection 137 1.86e-01 -6.54e-02 4.90e-01
Neurotransmitter receptors and postsynaptic signal transmission 132 1.94e-01 -6.54e-02 5.02e-01
G-protein beta:gamma signalling 29 5.42e-01 -6.54e-02 7.79e-01
Signaling by ERBB2 ECD mutants 15 6.62e-01 -6.52e-02 8.54e-01
Integration of energy metabolism 87 2.94e-01 -6.51e-02 5.95e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 2.46e-01 6.47e-02 5.59e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 2.46e-01 6.47e-02 5.59e-01
Aspartate and asparagine metabolism 8 7.52e-01 6.47e-02 9.02e-01
Activation of BAD and translocation to mitochondria 15 6.66e-01 -6.43e-02 8.56e-01
Regulation of TP53 Activity 151 1.74e-01 -6.41e-02 4.69e-01
tRNA processing in the nucleus 59 3.95e-01 6.40e-02 6.67e-01
Positive epigenetic regulation of rRNA expression 60 3.92e-01 -6.40e-02 6.66e-01
RNA Polymerase I Promoter Clearance 64 3.80e-01 -6.34e-02 6.66e-01
RNA Polymerase I Transcription 64 3.80e-01 -6.34e-02 6.66e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 4.68e-01 -6.33e-02 7.19e-01
ERKs are inactivated 13 6.93e-01 6.32e-02 8.70e-01
TP53 Regulates Transcription of Cell Death Genes 42 4.78e-01 6.32e-02 7.28e-01
RUNX2 regulates osteoblast differentiation 16 6.62e-01 -6.32e-02 8.54e-01
Activation of NF-kappaB in B cells 54 4.22e-01 -6.32e-02 6.84e-01
The activation of arylsulfatases 10 7.31e-01 6.27e-02 8.89e-01
RHO GTPases Activate ROCKs 18 6.45e-01 -6.26e-02 8.47e-01
L1CAM interactions 100 2.80e-01 -6.25e-02 5.84e-01
Signaling by Nuclear Receptors 210 1.19e-01 -6.25e-02 3.80e-01
Synaptic adhesion-like molecules 14 6.86e-01 -6.23e-02 8.65e-01
Hyaluronan metabolism 15 6.76e-01 6.23e-02 8.61e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 6.30e-01 6.22e-02 8.37e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 7.61e-01 -6.20e-02 9.07e-01
STAT5 Activation 7 7.76e-01 6.20e-02 9.15e-01
Processing of Capped Intronless Pre-mRNA 29 5.63e-01 6.20e-02 7.97e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 7.22e-01 6.19e-02 8.84e-01
Unfolded Protein Response (UPR) 84 3.27e-01 -6.19e-02 6.23e-01
NOD1/2 Signaling Pathway 36 5.21e-01 6.18e-02 7.66e-01
Activation of Matrix Metalloproteinases 20 6.33e-01 6.17e-02 8.39e-01
Pregnenolone biosynthesis 10 7.37e-01 -6.13e-02 8.92e-01
Protein lipoylation 10 7.37e-01 6.13e-02 8.92e-01
Diseases of signal transduction by growth factor receptors and second messengers 399 3.61e-02 -6.12e-02 2.03e-01
Gene expression (Transcription) 1391 1.40e-04 -6.10e-02 3.16e-03
Translation 293 7.43e-02 -6.06e-02 2.89e-01
Triglyceride biosynthesis 9 7.53e-01 -6.06e-02 9.03e-01
GPCR downstream signalling 396 3.98e-02 -6.02e-02 2.15e-01
SARS-CoV-2-host interactions 181 1.63e-01 6.01e-02 4.51e-01
Interleukin-12 family signaling 53 4.49e-01 -6.01e-02 7.03e-01
G alpha (q) signalling events 139 2.22e-01 -6.00e-02 5.39e-01
CREB phosphorylation 7 7.85e-01 -5.96e-02 9.20e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 7.71e-01 -5.95e-02 9.13e-01
TRP channels 21 6.37e-01 5.95e-02 8.42e-01
Netrin-1 signaling 34 5.51e-01 -5.92e-02 7.85e-01
Signal Transduction 2034 1.15e-05 -5.90e-02 3.62e-04
MAPK3 (ERK1) activation 9 7.59e-01 -5.90e-02 9.07e-01
Sensory processing of sound 57 4.41e-01 -5.90e-02 7.01e-01
Activation of NMDA receptors and postsynaptic events 70 3.94e-01 -5.89e-02 6.67e-01
ATF6 (ATF6-alpha) activates chaperones 12 7.24e-01 -5.89e-02 8.84e-01
FGFR3 ligand binding and activation 5 8.20e-01 -5.89e-02 9.33e-01
FGFR3c ligand binding and activation 5 8.20e-01 -5.89e-02 9.33e-01
RHOQ GTPase cycle 54 4.54e-01 5.88e-02 7.09e-01
Processing of Intronless Pre-mRNAs 20 6.49e-01 5.88e-02 8.47e-01
Signaling by cytosolic FGFR1 fusion mutants 18 6.69e-01 5.82e-02 8.57e-01
SHC-mediated cascade:FGFR3 10 7.50e-01 5.82e-02 9.01e-01
Transcription of the HIV genome 67 4.14e-01 -5.78e-02 6.79e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 7.19e-01 -5.77e-02 8.84e-01
DAP12 interactions 39 5.34e-01 5.76e-02 7.74e-01
Translation initiation complex formation 58 4.48e-01 5.76e-02 7.03e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 6.49e-01 5.74e-02 8.47e-01
Opioid Signalling 74 3.95e-01 -5.72e-02 6.67e-01
SRP-dependent cotranslational protein targeting to membrane 111 2.98e-01 -5.72e-02 5.96e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 5.88e-01 -5.72e-02 8.10e-01
Pyrimidine catabolism 9 7.67e-01 -5.69e-02 9.11e-01
Citric acid cycle (TCA cycle) 34 5.68e-01 -5.66e-02 7.98e-01
Constitutive Signaling by EGFRvIII 14 7.14e-01 -5.65e-02 8.84e-01
Signaling by EGFRvIII in Cancer 14 7.14e-01 -5.65e-02 8.84e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 3.95e-01 -5.64e-02 6.67e-01
Lipophagy 7 7.96e-01 -5.64e-02 9.24e-01
Oncogene Induced Senescence 33 5.75e-01 -5.63e-02 8.02e-01
Nuclear Envelope (NE) Reassembly 68 4.22e-01 -5.63e-02 6.84e-01
CDC42 GTPase cycle 139 2.52e-01 5.63e-02 5.64e-01
Signaling by GPCR 441 4.32e-02 -5.62e-02 2.24e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 5.66e-01 5.60e-02 7.97e-01
SUMOylation of DNA damage response and repair proteins 77 3.96e-01 5.60e-02 6.67e-01
Bile acid and bile salt metabolism 28 6.08e-01 -5.59e-02 8.25e-01
Toll Like Receptor 2 (TLR2) Cascade 109 3.13e-01 5.59e-02 6.07e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 3.13e-01 5.59e-02 6.07e-01
RND3 GTPase cycle 35 5.67e-01 -5.59e-02 7.97e-01
Signaling by ROBO receptors 189 1.85e-01 -5.59e-02 4.90e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.16e-01 5.58e-02 8.28e-01
G-protein activation 19 6.74e-01 -5.57e-02 8.59e-01
Host Interactions of HIV factors 118 2.97e-01 -5.56e-02 5.95e-01
Sphingolipid de novo biosynthesis 34 5.75e-01 -5.56e-02 8.02e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 6.93e-01 -5.52e-02 8.70e-01
Intracellular signaling by second messengers 264 1.23e-01 -5.52e-02 3.85e-01
Nuclear Envelope Breakdown 53 4.88e-01 5.50e-02 7.34e-01
Metabolism 1808 1.06e-04 -5.50e-02 2.57e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 74 4.14e-01 -5.50e-02 6.79e-01
mRNA Capping 29 6.08e-01 -5.50e-02 8.25e-01
Diseases associated with the TLR signaling cascade 29 6.10e-01 5.48e-02 8.25e-01
Diseases of Immune System 29 6.10e-01 5.48e-02 8.25e-01
Regulation of HSF1-mediated heat shock response 78 4.03e-01 5.47e-02 6.73e-01
Signaling by BMP 23 6.50e-01 5.47e-02 8.48e-01
Nef Mediated CD4 Down-regulation 9 7.77e-01 -5.46e-02 9.15e-01
Acyl chain remodelling of PS 14 7.23e-01 5.46e-02 8.84e-01
Sperm Motility And Taxes 6 8.17e-01 5.46e-02 9.33e-01
Role of ABL in ROBO-SLIT signaling 6 8.18e-01 -5.42e-02 9.33e-01
ALK mutants bind TKIs 11 7.56e-01 5.42e-02 9.05e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 5.03e-01 -5.38e-02 7.46e-01
RAB GEFs exchange GTP for GDP on RABs 89 3.82e-01 -5.37e-02 6.66e-01
Ovarian tumor domain proteases 37 5.73e-01 -5.36e-02 7.99e-01
Elastic fibre formation 33 5.94e-01 -5.36e-02 8.17e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 6.95e-01 -5.34e-02 8.72e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 7.95e-01 -5.32e-02 9.24e-01
Extra-nuclear estrogen signaling 65 4.59e-01 -5.31e-02 7.13e-01
Induction of Cell-Cell Fusion 8 7.95e-01 5.29e-02 9.24e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 7.73e-01 5.28e-02 9.14e-01
Regulation of CDH11 function 9 7.85e-01 -5.26e-02 9.20e-01
DCC mediated attractive signaling 13 7.43e-01 5.25e-02 8.97e-01
Synthesis of bile acids and bile salts 25 6.52e-01 -5.21e-02 8.49e-01
Regulation of expression of SLITs and ROBOs 149 2.72e-01 -5.21e-02 5.78e-01
Thyroxine biosynthesis 5 8.41e-01 5.18e-02 9.45e-01
Signaling by FGFR 73 4.46e-01 -5.16e-02 7.03e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 7.78e-01 -5.15e-02 9.15e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 7.30e-01 -5.15e-02 8.88e-01
Adipogenesis 95 3.87e-01 -5.14e-02 6.66e-01
Ubiquinol biosynthesis 13 7.50e-01 5.11e-02 9.01e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 6.72e-01 -5.10e-02 8.59e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 6.72e-01 -5.10e-02 8.59e-01
Phase II - Conjugation of compounds 68 4.69e-01 5.07e-02 7.20e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 7.92e-01 5.07e-02 9.24e-01
Activation of gene expression by SREBF (SREBP) 42 5.70e-01 -5.07e-02 7.98e-01
Phosphate bond hydrolysis by NUDT proteins 7 8.17e-01 5.06e-02 9.33e-01
Mitochondrial calcium ion transport 22 6.82e-01 5.05e-02 8.64e-01
Glycosphingolipid metabolism 47 5.50e-01 -5.04e-02 7.85e-01
Biosynthesis of E-series 18(S)-resolvins 5 8.46e-01 5.03e-02 9.46e-01
Signaling by PDGFR in disease 19 7.05e-01 -5.02e-02 8.79e-01
Mitotic Prophase 96 3.97e-01 -5.01e-02 6.67e-01
Transcriptional Regulation by TP53 343 1.13e-01 -4.99e-02 3.66e-01
Cellular response to heat stress 92 4.09e-01 4.98e-02 6.77e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 7.75e-01 -4.98e-02 9.15e-01
Cargo recognition for clathrin-mediated endocytosis 88 4.21e-01 4.97e-02 6.84e-01
IKK complex recruitment mediated by RIP1 23 6.81e-01 4.95e-02 8.64e-01
VEGFR2 mediated vascular permeability 26 6.63e-01 -4.94e-02 8.54e-01
MET receptor recycling 9 8.00e-01 4.89e-02 9.25e-01
MyD88-independent TLR4 cascade 108 3.80e-01 4.89e-02 6.66e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 3.80e-01 4.89e-02 6.66e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 5.25e-01 4.87e-02 7.68e-01
Tie2 Signaling 16 7.36e-01 -4.87e-02 8.92e-01
KEAP1-NFE2L2 pathway 106 3.89e-01 -4.84e-02 6.66e-01
Signaling by ERBB2 TMD/JMD mutants 17 7.30e-01 4.84e-02 8.88e-01
Autophagy 142 3.20e-01 -4.83e-02 6.16e-01
HS-GAG biosynthesis 19 7.16e-01 -4.83e-02 8.84e-01
PIP3 activates AKT signaling 232 2.08e-01 -4.80e-02 5.21e-01
Early Phase of HIV Life Cycle 14 7.60e-01 4.72e-02 9.07e-01
Protein-protein interactions at synapses 54 5.54e-01 4.66e-02 7.88e-01
HATs acetylate histones 92 4.40e-01 4.66e-02 7.01e-01
Thromboxane signalling through TP receptor 20 7.19e-01 -4.64e-02 8.84e-01
Nervous system development 473 8.57e-02 -4.61e-02 3.12e-01
Negative regulation of the PI3K/AKT network 91 4.49e-01 -4.60e-02 7.03e-01
Downstream signaling of activated FGFR1 22 7.10e-01 4.59e-02 8.82e-01
Myogenesis 20 7.24e-01 4.56e-02 8.84e-01
Trafficking of GluR2-containing AMPA receptors 11 7.94e-01 4.56e-02 9.24e-01
TAK1-dependent IKK and NF-kappa-B activation 43 6.05e-01 4.55e-02 8.23e-01
G-protein mediated events 43 6.05e-01 -4.55e-02 8.23e-01
Signaling by TGFB family members 137 3.61e-01 -4.52e-02 6.58e-01
Negative regulation of FGFR2 signaling 24 7.03e-01 -4.49e-02 8.78e-01
Axon guidance 455 1.02e-01 -4.48e-02 3.45e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 5.62e-01 -4.45e-02 7.95e-01
Biosynthesis of maresins 5 8.63e-01 -4.44e-02 9.52e-01
Selenoamino acid metabolism 115 4.11e-01 4.43e-02 6.79e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 5.13e-01 -4.42e-02 7.56e-01
Cation-coupled Chloride cotransporters 6 8.52e-01 4.40e-02 9.49e-01
Interleukin-1 signaling 99 4.50e-01 4.39e-02 7.03e-01
Trafficking and processing of endosomal TLR 13 7.84e-01 -4.38e-02 9.20e-01
Activation of BH3-only proteins 29 6.84e-01 -4.37e-02 8.65e-01
RNA Polymerase III Chain Elongation 18 7.49e-01 -4.36e-02 9.00e-01
ECM proteoglycans 45 6.14e-01 -4.35e-02 8.26e-01
Paracetamol ADME 19 7.43e-01 4.35e-02 8.97e-01
SUMOylation of DNA replication proteins 46 6.12e-01 4.32e-02 8.25e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 8.04e-01 -4.32e-02 9.27e-01
Sphingolipid metabolism 92 4.76e-01 -4.30e-02 7.27e-01
SUMOylation of transcription cofactors 44 6.21e-01 4.30e-02 8.32e-01
Formation of WDR5-containing histone-modifying complexes 42 6.30e-01 4.29e-02 8.37e-01
Mitochondrial iron-sulfur cluster biogenesis 13 7.89e-01 -4.28e-02 9.23e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.99e-01 4.22e-02 8.75e-01
RET signaling 32 6.84e-01 -4.16e-02 8.65e-01
RHO GTPases activate KTN1 11 8.14e-01 -4.11e-02 9.33e-01
Other semaphorin interactions 16 7.77e-01 -4.10e-02 9.15e-01
Diseases associated with glycosylation precursor biosynthesis 15 7.84e-01 -4.09e-02 9.20e-01
Epigenetic regulation of gene expression 263 2.57e-01 -4.06e-02 5.68e-01
FGFR4 ligand binding and activation 5 8.75e-01 -4.05e-02 9.57e-01
Acyl chain remodelling of PG 11 8.16e-01 -4.05e-02 9.33e-01
Biosynthesis of DHA-derived SPMs 13 8.00e-01 4.05e-02 9.25e-01
Transmission across Chemical Synapses 179 3.53e-01 -4.03e-02 6.50e-01
SHC-mediated cascade:FGFR2 13 8.02e-01 -4.01e-02 9.26e-01
Regulation of BACH1 activity 11 8.19e-01 -3.99e-02 9.33e-01
Germ layer formation at gastrulation 9 8.36e-01 3.99e-02 9.43e-01
PI3K/AKT Signaling in Cancer 83 5.31e-01 3.98e-02 7.73e-01
Metabolism of lipids 632 8.82e-02 -3.98e-02 3.16e-01
Activation of RAC1 downstream of NMDARs 7 8.57e-01 3.94e-02 9.50e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 6.74e-01 -3.94e-02 8.59e-01
Deubiquitination 225 3.08e-01 -3.94e-02 6.04e-01
Inwardly rectifying K+ channels 22 7.51e-01 -3.91e-02 9.01e-01
RHOBTB GTPase Cycle 35 6.90e-01 -3.90e-02 8.68e-01
Post-translational protein phosphorylation 67 5.81e-01 -3.90e-02 8.04e-01
Defective HLCS causes multiple carboxylase deficiency 7 8.58e-01 -3.89e-02 9.51e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 7.58e-01 3.89e-02 9.06e-01
C-type lectin receptors (CLRs) 116 4.72e-01 -3.87e-02 7.22e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 7.90e-01 3.85e-02 9.23e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 8.61e-01 3.81e-02 9.52e-01
PLC beta mediated events 39 6.81e-01 -3.81e-02 8.64e-01
HCMV Infection 106 4.99e-01 -3.80e-02 7.44e-01
mTORC1-mediated signalling 24 7.48e-01 -3.78e-02 9.00e-01
Complex I biogenesis 66 5.95e-01 3.78e-02 8.18e-01
Regulation of MITF-M-dependent genes involved in pigmentation 35 6.99e-01 -3.77e-02 8.75e-01
RNA Polymerase III Abortive And Retractive Initiation 40 6.80e-01 3.77e-02 8.63e-01
RNA Polymerase III Transcription 40 6.80e-01 3.77e-02 8.63e-01
FRS-mediated FGFR1 signaling 15 8.01e-01 3.76e-02 9.25e-01
Death Receptor Signaling 145 4.35e-01 -3.75e-02 6.97e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 8.85e-01 3.74e-02 9.63e-01
SARS-CoV-1-host interactions 94 5.32e-01 -3.73e-02 7.73e-01
Signaling by FGFR2 61 6.17e-01 -3.70e-02 8.29e-01
Golgi Associated Vesicle Biogenesis 55 6.36e-01 -3.69e-02 8.41e-01
Cap-dependent Translation Initiation 118 4.91e-01 3.67e-02 7.36e-01
Eukaryotic Translation Initiation 118 4.91e-01 3.67e-02 7.36e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 5.04e-01 3.67e-02 7.47e-01
Developmental Biology 906 6.15e-02 -3.67e-02 2.65e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 4.95e-01 -3.65e-02 7.41e-01
Defective B3GALTL causes PpS 24 7.57e-01 -3.64e-02 9.06e-01
NGF-stimulated transcription 32 7.22e-01 3.64e-02 8.84e-01
RHOA GTPase cycle 138 4.65e-01 -3.60e-02 7.16e-01
Zinc transporters 12 8.29e-01 -3.59e-02 9.41e-01
MicroRNA (miRNA) biogenesis 24 7.62e-01 -3.58e-02 9.07e-01
RHOJ GTPase cycle 49 6.67e-01 3.55e-02 8.56e-01
Activated NTRK2 signals through FRS2 and FRS3 8 8.62e-01 3.55e-02 9.52e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 6.46e-01 -3.54e-02 8.47e-01
Negative regulation of FGFR4 signaling 22 7.74e-01 -3.54e-02 9.14e-01
Signaling by Insulin receptor 63 6.27e-01 3.54e-02 8.35e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 6.62e-01 3.54e-02 8.54e-01
Role of second messengers in netrin-1 signaling 6 8.81e-01 -3.53e-02 9.61e-01
Metabolism of cofactors 25 7.61e-01 3.52e-02 9.07e-01
Glutamate Neurotransmitter Release Cycle 20 7.85e-01 -3.52e-02 9.20e-01
Nicotinate metabolism 26 7.56e-01 -3.52e-02 9.05e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 5.25e-01 3.51e-02 7.68e-01
Signaling by TGF-beta Receptor Complex 90 5.66e-01 -3.51e-02 7.97e-01
rRNA modification in the nucleus and cytosol 59 6.42e-01 3.50e-02 8.45e-01
RNA Polymerase III Transcription Initiation 36 7.17e-01 3.49e-02 8.84e-01
Impaired BRCA2 binding to RAD51 35 7.21e-01 -3.49e-02 8.84e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 7.17e-01 -3.49e-02 8.84e-01
Negative regulation of MET activity 18 7.98e-01 -3.49e-02 9.25e-01
Regulation of PTEN gene transcription 59 6.43e-01 -3.49e-02 8.46e-01
Pexophagy 10 8.50e-01 3.46e-02 9.47e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 7.94e-01 -3.45e-02 9.24e-01
Signaling by NTRK3 (TRKC) 15 8.17e-01 -3.45e-02 9.33e-01
Reversal of alkylation damage by DNA dioxygenases 7 8.75e-01 -3.42e-02 9.57e-01
Signaling by Non-Receptor Tyrosine Kinases 47 6.85e-01 3.42e-02 8.65e-01
Signaling by PTK6 47 6.85e-01 3.42e-02 8.65e-01
Uptake and actions of bacterial toxins 27 7.60e-01 3.40e-02 9.07e-01
Sensory processing of sound by inner hair cells of the cochlea 54 6.66e-01 -3.40e-02 8.56e-01
Signaling by Erythropoietin 24 7.74e-01 -3.39e-02 9.14e-01
Signaling by Receptor Tyrosine Kinases 443 2.24e-01 -3.37e-02 5.39e-01
Non-integrin membrane-ECM interactions 46 6.92e-01 3.37e-02 8.70e-01
Signaling by Retinoic Acid 29 7.55e-01 -3.35e-02 9.04e-01
Transcriptional regulation of white adipocyte differentiation 77 6.12e-01 -3.34e-02 8.25e-01
Noncanonical activation of NOTCH3 8 8.71e-01 -3.32e-02 9.55e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 8.42e-01 -3.32e-02 9.45e-01
O-glycosylation of TSR domain-containing proteins 25 7.75e-01 -3.30e-02 9.15e-01
Macroautophagy 128 5.20e-01 -3.29e-02 7.65e-01
Regulation of PTEN mRNA translation 12 8.43e-01 -3.29e-02 9.45e-01
Chaperone Mediated Autophagy 20 7.99e-01 -3.28e-02 9.25e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 20 8.00e-01 3.28e-02 9.25e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 8.34e-01 -3.24e-02 9.43e-01
RHO GTPase cycle 408 2.62e-01 -3.24e-02 5.72e-01
Cellular response to starvation 148 4.98e-01 3.23e-02 7.43e-01
trans-Golgi Network Vesicle Budding 69 6.46e-01 -3.20e-02 8.47e-01
Synthesis of UDP-N-acetyl-glucosamine 8 8.76e-01 -3.18e-02 9.57e-01
NR1H2 and NR1H3-mediated signaling 38 7.36e-01 3.15e-02 8.92e-01
Aerobic respiration and respiratory electron transport 245 3.96e-01 -3.15e-02 6.67e-01
Cellular response to chemical stress 178 4.69e-01 -3.14e-02 7.20e-01
Vitamin D (calciferol) metabolism 10 8.63e-01 -3.14e-02 9.52e-01
IRAK4 deficiency (TLR2/4) 15 8.34e-01 -3.13e-02 9.43e-01
Ion channel transport 136 5.28e-01 3.13e-02 7.71e-01
NRAGE signals death through JNK 52 6.99e-01 -3.11e-02 8.75e-01
CLEC7A (Dectin-1) signaling 85 6.22e-01 -3.10e-02 8.32e-01
ER Quality Control Compartment (ERQC) 21 8.06e-01 3.09e-02 9.28e-01
Late Phase of HIV Life Cycle 131 5.45e-01 -3.06e-02 7.81e-01
Metabolism of porphyrins 22 8.04e-01 -3.05e-02 9.27e-01
Disorders of transmembrane transporters 134 5.42e-01 3.05e-02 7.79e-01
Signaling by NTRKs 116 5.72e-01 -3.04e-02 7.99e-01
Aspirin ADME 13 8.50e-01 -3.04e-02 9.47e-01
RHOB GTPase cycle 64 6.74e-01 -3.04e-02 8.59e-01
Plasma lipoprotein clearance 33 7.63e-01 -3.03e-02 9.07e-01
Formation of a pool of free 40S subunits 100 6.01e-01 3.02e-02 8.21e-01
Cellular responses to stimuli 776 1.55e-01 -3.00e-02 4.39e-01
Toll Like Receptor 3 (TLR3) Cascade 104 6.02e-01 2.96e-02 8.21e-01
GPCR ligand binding 241 4.30e-01 -2.95e-02 6.93e-01
RA biosynthesis pathway 13 8.54e-01 2.95e-02 9.49e-01
Bicarbonate transporters 9 8.78e-01 2.95e-02 9.58e-01
RAC2 GTPase cycle 85 6.39e-01 2.94e-02 8.43e-01
Signaling by NTRK1 (TRKA) 102 6.09e-01 -2.93e-02 8.25e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 8.66e-01 -2.93e-02 9.54e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 8.94e-01 -2.91e-02 9.65e-01
MET activates PTK2 signaling 21 8.18e-01 2.90e-02 9.33e-01
Diseases of glycosylation 104 6.12e-01 -2.88e-02 8.25e-01
Sema4D in semaphorin signaling 22 8.16e-01 -2.87e-02 9.33e-01
Formation of ATP by chemiosmotic coupling 20 8.25e-01 2.86e-02 9.38e-01
Receptor Mediated Mitophagy 11 8.70e-01 -2.86e-02 9.55e-01
Attachment and Entry 9694614 13 8.59e-01 -2.84e-02 9.51e-01
Signaling by BRAF and RAF1 fusions 59 7.06e-01 -2.84e-02 8.79e-01
TRAF6 mediated NF-kB activation 23 8.14e-01 2.84e-02 9.33e-01
Influenza Viral RNA Transcription and Replication 135 5.69e-01 2.84e-02 7.98e-01
Downstream signaling of activated FGFR4 18 8.35e-01 2.83e-02 9.43e-01
Modulation by Mtb of host immune system 7 8.98e-01 -2.81e-02 9.66e-01
RHOT2 GTPase cycle 7 8.99e-01 2.78e-02 9.66e-01
Sphingolipid catabolism 11 8.73e-01 2.78e-02 9.57e-01
Killing mechanisms 9 8.86e-01 2.75e-02 9.63e-01
WNT5:FZD7-mediated leishmania damping 9 8.86e-01 2.75e-02 9.63e-01
Formation of the cornified envelope 33 7.86e-01 2.73e-02 9.20e-01
Interleukin-37 signaling 19 8.37e-01 -2.73e-02 9.44e-01
Regulation of TLR by endogenous ligand 15 8.56e-01 -2.71e-02 9.49e-01
Signaling by NTRK2 (TRKB) 20 8.35e-01 -2.69e-02 9.43e-01
Loss of Function of SMAD2/3 in Cancer 7 9.02e-01 -2.68e-02 9.66e-01
Phospholipase C-mediated cascade: FGFR1 8 8.96e-01 -2.68e-02 9.65e-01
Gene Silencing by RNA 87 6.66e-01 -2.68e-02 8.56e-01
Retinoid metabolism and transport 23 8.24e-01 2.67e-02 9.38e-01
Negative regulation of FGFR1 signaling 25 8.17e-01 2.67e-02 9.33e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 8.90e-01 -2.67e-02 9.63e-01
Formation of the Editosome 6 9.10e-01 -2.67e-02 9.69e-01
mRNA Editing: C to U Conversion 6 9.10e-01 -2.67e-02 9.69e-01
Signaling by LTK 10 8.84e-01 2.66e-02 9.63e-01
Signaling by FGFR2 in disease 33 7.92e-01 -2.66e-02 9.24e-01
Signaling by NOTCH4 68 7.05e-01 -2.66e-02 8.79e-01
FLT3 signaling in disease 27 8.13e-01 -2.63e-02 9.33e-01
Signaling by FGFR3 32 7.97e-01 -2.63e-02 9.25e-01
RNA Polymerase I Promoter Escape 45 7.63e-01 -2.59e-02 9.07e-01
Influenza Infection 154 5.82e-01 2.57e-02 8.04e-01
Cell-cell junction organization 56 7.40e-01 2.57e-02 8.94e-01
Signaling by Interleukins 387 3.86e-01 -2.57e-02 6.66e-01
GABA receptor activation 35 7.94e-01 -2.55e-02 9.24e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 6.87e-01 -2.54e-02 8.65e-01
Cellular responses to stress 694 2.57e-01 -2.52e-02 5.68e-01
Signaling by Activin 13 8.75e-01 -2.51e-02 9.57e-01
RAC3 GTPase cycle 86 6.87e-01 2.51e-02 8.65e-01
SHC-related events triggered by IGF1R 7 9.09e-01 2.51e-02 9.69e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 8.42e-01 -2.50e-02 9.45e-01
Neurodegenerative Diseases 21 8.42e-01 -2.50e-02 9.45e-01
Loss of Function of TGFBR1 in Cancer 7 9.09e-01 -2.50e-02 9.69e-01
Gastrulation 73 7.12e-01 -2.50e-02 8.84e-01
Cell death signalling via NRAGE, NRIF and NADE 69 7.21e-01 -2.49e-02 8.84e-01
Aflatoxin activation and detoxification 14 8.72e-01 2.48e-02 9.56e-01
Linoleic acid (LA) metabolism 7 9.10e-01 -2.46e-02 9.69e-01
Oncogenic MAPK signaling 75 7.14e-01 2.45e-02 8.84e-01
Regulation of Expression and Function of Type II Classical Cadherins 23 8.39e-01 2.44e-02 9.45e-01
Regulation of Homotypic Cell-Cell Adhesion 23 8.39e-01 2.44e-02 9.45e-01
RNA Polymerase III Transcription Termination 22 8.43e-01 -2.44e-02 9.45e-01
HIV Life Cycle 144 6.14e-01 -2.43e-02 8.26e-01
IRAK2 mediated activation of TAK1 complex 10 8.96e-01 2.39e-02 9.65e-01
Degradation of the extracellular matrix 92 6.92e-01 2.39e-02 8.70e-01
Glucose metabolism 76 7.24e-01 2.34e-02 8.84e-01
Signaling by FGFR4 32 8.19e-01 -2.34e-02 9.33e-01
Diseases of carbohydrate metabolism 29 8.28e-01 2.33e-02 9.40e-01
Class A/1 (Rhodopsin-like receptors) 176 5.95e-01 -2.32e-02 8.17e-01
RHOBTB1 GTPase cycle 23 8.48e-01 2.32e-02 9.46e-01
rRNA processing 213 5.60e-01 2.31e-02 7.95e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.23e-01 -2.28e-02 9.72e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.23e-01 -2.28e-02 9.72e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 8.38e-01 2.28e-02 9.44e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 9.01e-01 2.26e-02 9.66e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 8.88e-01 -2.25e-02 9.63e-01
Interleukin-27 signaling 11 8.99e-01 -2.20e-02 9.66e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 8.95e-01 -2.19e-02 9.65e-01
Phospholipase C-mediated cascade; FGFR3 5 9.34e-01 2.15e-02 9.75e-01
Deadenylation-dependent mRNA decay 50 7.94e-01 -2.14e-02 9.24e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 9.12e-01 -2.13e-02 9.69e-01
Assembly and cell surface presentation of NMDA receptors 30 8.41e-01 2.12e-02 9.45e-01
Signaling by FGFR in disease 52 7.91e-01 -2.12e-02 9.24e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 7.37e-01 2.12e-02 8.92e-01
Synthesis of very long-chain fatty acyl-CoAs 22 8.64e-01 -2.11e-02 9.52e-01
Processing of Capped Intron-Containing Pre-mRNA 279 5.49e-01 2.09e-02 7.84e-01
SHC-mediated cascade:FGFR4 11 9.08e-01 -2.02e-02 9.69e-01
Xenobiotics 9 9.17e-01 2.01e-02 9.72e-01
Fibronectin matrix formation 6 9.32e-01 -2.01e-02 9.75e-01
SHC-mediated cascade:FGFR1 13 9.01e-01 2.00e-02 9.66e-01
Metabolism of carbohydrates 236 6.00e-01 -1.98e-02 8.21e-01
Diseases of metabolism 198 6.33e-01 -1.97e-02 8.39e-01
Synthesis of IP3 and IP4 in the cytosol 22 8.75e-01 -1.94e-02 9.57e-01
Maternal to zygotic transition (MZT) 71 7.79e-01 -1.93e-02 9.16e-01
PI5P Regulates TP53 Acetylation 8 9.25e-01 1.91e-02 9.73e-01
Purine catabolism 16 8.95e-01 -1.91e-02 9.65e-01
EGFR Transactivation by Gastrin 7 9.30e-01 1.91e-02 9.75e-01
Mitochondrial protein degradation 96 7.47e-01 -1.90e-02 9.00e-01
PI3K Cascade 31 8.55e-01 -1.90e-02 9.49e-01
Processing of SMDT1 15 9.00e-01 1.87e-02 9.66e-01
Transcriptional Regulation by VENTX 38 8.44e-01 -1.84e-02 9.45e-01
Cytosolic sensors of pathogen-associated DNA 63 8.01e-01 -1.84e-02 9.25e-01
WNT ligand biogenesis and trafficking 20 8.87e-01 -1.83e-02 9.63e-01
Vitamin C (ascorbate) metabolism 8 9.30e-01 -1.78e-02 9.75e-01
FGFR1 ligand binding and activation 10 9.22e-01 -1.78e-02 9.72e-01
Dopamine Neurotransmitter Release Cycle 20 8.92e-01 1.75e-02 9.65e-01
mRNA Splicing 211 6.67e-01 -1.72e-02 8.56e-01
Signaling by LTK in cancer 7 9.37e-01 -1.71e-02 9.77e-01
Adenylate cyclase inhibitory pathway 11 9.22e-01 1.71e-02 9.72e-01
Regulation of CDH11 Expression and Function 22 8.90e-01 -1.71e-02 9.63e-01
p75 NTR receptor-mediated signalling 89 7.84e-01 -1.68e-02 9.20e-01
RHOH GTPase cycle 33 8.68e-01 -1.67e-02 9.54e-01
Glycolysis 68 8.12e-01 1.66e-02 9.33e-01
CD28 dependent PI3K/Akt signaling 22 8.93e-01 -1.65e-02 9.65e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 8.64e-01 -1.65e-02 9.52e-01
Digestion and absorption 7 9.40e-01 1.64e-02 9.77e-01
RHOF GTPase cycle 38 8.61e-01 -1.64e-02 9.52e-01
PKMTs methylate histone lysines 42 8.55e-01 -1.63e-02 9.49e-01
ERK/MAPK targets 22 8.95e-01 1.62e-02 9.65e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 9.11e-01 1.61e-02 9.69e-01
RNA polymerase II transcribes snRNA genes 71 8.17e-01 1.59e-02 9.33e-01
IGF1R signaling cascade 37 8.68e-01 -1.58e-02 9.54e-01
RAC1 GTPase cycle 170 7.23e-01 1.58e-02 8.84e-01
Adherens junctions interactions 37 8.70e-01 -1.56e-02 9.55e-01
Toll-like Receptor Cascades 162 7.32e-01 1.56e-02 8.89e-01
Vitamin B2 (riboflavin) metabolism 6 9.48e-01 1.55e-02 9.82e-01
Keratinization 34 8.76e-01 1.55e-02 9.57e-01
WNT mediated activation of DVL 8 9.40e-01 1.55e-02 9.77e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 7.97e-01 1.54e-02 9.25e-01
Neuronal System 262 6.69e-01 -1.53e-02 8.57e-01
Transport of small molecules 548 5.42e-01 -1.52e-02 7.79e-01
Activation of the AP-1 family of transcription factors 10 9.34e-01 -1.52e-02 9.75e-01
Incretin synthesis, secretion, and inactivation 14 9.22e-01 1.51e-02 9.72e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 9.22e-01 1.51e-02 9.72e-01
Eukaryotic Translation Elongation 93 8.02e-01 -1.50e-02 9.26e-01
Toll Like Receptor 4 (TLR4) Cascade 138 7.62e-01 1.49e-02 9.07e-01
RAS signaling downstream of NF1 loss-of-function variants 7 9.46e-01 1.47e-02 9.82e-01
Mitochondrial protein import 63 8.41e-01 -1.46e-02 9.45e-01
FRS-mediated FGFR2 signaling 15 9.23e-01 -1.45e-02 9.72e-01
DNA Damage Recognition in GG-NER 38 8.78e-01 -1.44e-02 9.58e-01
RAF activation 32 8.90e-01 -1.42e-02 9.63e-01
MITF-M-regulated melanocyte development 110 8.07e-01 -1.35e-02 9.29e-01
Maturation of nucleoprotein 9683610 11 9.39e-01 -1.33e-02 9.77e-01
TP53 Regulates Metabolic Genes 77 8.40e-01 1.33e-02 9.45e-01
MTOR signalling 39 8.86e-01 1.32e-02 9.63e-01
Selenocysteine synthesis 92 8.29e-01 1.30e-02 9.41e-01
FGFR2 alternative splicing 25 9.11e-01 1.29e-02 9.69e-01
Neurotransmitter release cycle 38 8.91e-01 1.28e-02 9.64e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 7.68e-01 1.28e-02 9.11e-01
Axonal growth inhibition (RHOA activation) 7 9.53e-01 -1.27e-02 9.87e-01
p75NTR regulates axonogenesis 7 9.53e-01 -1.27e-02 9.87e-01
Sensory perception of taste 23 9.16e-01 1.27e-02 9.72e-01
NFE2L2 regulating tumorigenic genes 11 9.43e-01 -1.25e-02 9.80e-01
ISG15 antiviral mechanism 72 8.55e-01 -1.24e-02 9.49e-01
SUMO E3 ligases SUMOylate target proteins 161 7.88e-01 1.23e-02 9.21e-01
Cellular responses to mechanical stimuli 83 8.47e-01 -1.23e-02 9.46e-01
Response of endothelial cells to shear stress 83 8.47e-01 -1.23e-02 9.46e-01
IRS-mediated signalling 35 9.01e-01 -1.22e-02 9.66e-01
Phenylalanine metabolism 5 9.63e-01 -1.21e-02 9.90e-01
Nucleotide Excision Repair 108 8.29e-01 -1.20e-02 9.41e-01
HCMV Early Events 84 8.54e-01 1.16e-02 9.49e-01
Assembly of collagen fibrils and other multimeric structures 41 8.98e-01 -1.16e-02 9.66e-01
RND1 GTPase cycle 36 9.05e-01 1.15e-02 9.67e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.16e-01 1.15e-02 9.72e-01
Acyl chain remodelling of PI 10 9.50e-01 1.15e-02 9.84e-01
Interleukin-4 and Interleukin-13 signaling 89 8.52e-01 -1.15e-02 9.49e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 8.34e-01 -1.14e-02 9.43e-01
Nonsense-Mediated Decay (NMD) 114 8.34e-01 -1.14e-02 9.43e-01
PI Metabolism 79 8.62e-01 1.13e-02 9.52e-01
Signaling by EGFR in Cancer 22 9.27e-01 -1.13e-02 9.74e-01
STING mediated induction of host immune responses 15 9.40e-01 1.12e-02 9.77e-01
Mitochondrial biogenesis 91 8.57e-01 -1.09e-02 9.50e-01
Viral mRNA Translation 88 8.60e-01 1.09e-02 9.51e-01
Interleukin-1 family signaling 127 8.35e-01 1.07e-02 9.43e-01
Respiratory electron transport 149 8.22e-01 1.07e-02 9.36e-01
Complex III assembly 23 9.30e-01 1.05e-02 9.75e-01
Downstream signaling of activated FGFR2 20 9.35e-01 1.05e-02 9.76e-01
Metabolism of fat-soluble vitamins 26 9.26e-01 -1.05e-02 9.73e-01
Sensory Perception 188 8.05e-01 1.04e-02 9.27e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 9.65e-01 1.04e-02 9.90e-01
TGFBR1 KD Mutants in Cancer 6 9.65e-01 1.04e-02 9.90e-01
Nucleotide catabolism 29 9.23e-01 1.03e-02 9.72e-01
SARS-CoV-2 Infection 263 7.73e-01 -1.03e-02 9.14e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 9.45e-01 1.03e-02 9.81e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 9.37e-01 -1.02e-02 9.77e-01
Potassium Channels 62 8.90e-01 1.02e-02 9.63e-01
Defective Intrinsic Pathway for Apoptosis 24 9.33e-01 -9.84e-03 9.75e-01
Transcriptional activation of mitochondrial biogenesis 52 9.03e-01 9.74e-03 9.67e-01
RHOG GTPase cycle 70 8.89e-01 -9.61e-03 9.63e-01
Signaling by FGFR1 42 9.15e-01 -9.47e-03 9.72e-01
Transcriptional regulation by small RNAs 61 9.04e-01 8.90e-03 9.67e-01
Nuclear Events (kinase and transcription factor activation) 54 9.10e-01 8.87e-03 9.69e-01
Hyaluronan uptake and degradation 12 9.58e-01 -8.77e-03 9.89e-01
Transcriptional regulation by RUNX3 80 8.95e-01 8.50e-03 9.65e-01
Neurexins and neuroligins 35 9.32e-01 -8.32e-03 9.75e-01
Anchoring fibril formation 7 9.70e-01 -8.30e-03 9.92e-01
RNA Polymerase I Transcription Initiation 47 9.23e-01 8.10e-03 9.72e-01
Tryptophan catabolism 12 9.64e-01 7.51e-03 9.90e-01
Uptake and function of diphtheria toxin 6 9.75e-01 -7.44e-03 9.93e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 9.57e-01 7.19e-03 9.89e-01
Trafficking of AMPA receptors 19 9.57e-01 7.19e-03 9.89e-01
Signaling by MET 67 9.21e-01 -7.04e-03 9.72e-01
Signaling by ERBB2 44 9.36e-01 -7.02e-03 9.76e-01
rRNA processing in the nucleus and cytosol 189 8.70e-01 6.91e-03 9.55e-01
IRS-related events triggered by IGF1R 36 9.47e-01 -6.43e-03 9.82e-01
Sensing of DNA Double Strand Breaks 6 9.79e-01 6.26e-03 9.95e-01
Glycosaminoglycan metabolism 95 9.16e-01 6.25e-03 9.72e-01
FRS-mediated FGFR4 signaling 13 9.69e-01 6.24e-03 9.92e-01
Synthesis of PIPs at the plasma membrane 52 9.39e-01 6.12e-03 9.77e-01
Peptide chain elongation 88 9.22e-01 6.04e-03 9.72e-01
Proton-coupled monocarboxylate transport 6 9.80e-01 -5.96e-03 9.95e-01
Acetylcholine Neurotransmitter Release Cycle 11 9.73e-01 -5.82e-03 9.93e-01
SARS-CoV-1 modulates host translation machinery 36 9.55e-01 -5.49e-03 9.87e-01
Interleukin-6 family signaling 18 9.69e-01 5.21e-03 9.92e-01
Integration of provirus 9 9.79e-01 5.06e-03 9.95e-01
Clathrin-mediated endocytosis 127 9.22e-01 -5.05e-03 9.72e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 9.83e-01 -5.00e-03 9.96e-01
mRNA Splicing - Major Pathway 203 9.03e-01 -4.98e-03 9.66e-01
HDR through Single Strand Annealing (SSA) 37 9.59e-01 4.84e-03 9.90e-01
Metalloprotease DUBs 20 9.71e-01 -4.77e-03 9.92e-01
VLDLR internalisation and degradation 16 9.74e-01 4.75e-03 9.93e-01
Downregulation of ERBB2 signaling 24 9.69e-01 4.52e-03 9.92e-01
Interleukin-18 signaling 6 9.85e-01 -4.50e-03 9.97e-01
SLC-mediated transmembrane transport 171 9.19e-01 4.50e-03 9.72e-01
Phospholipid metabolism 182 9.18e-01 4.45e-03 9.72e-01
Chemokine receptors bind chemokines 39 9.63e-01 4.24e-03 9.90e-01
Metabolism of RNA 717 8.48e-01 -4.22e-03 9.46e-01
SARS-CoV-2 modulates host translation machinery 49 9.61e-01 4.08e-03 9.90e-01
Caspase activation via Death Receptors in the presence of ligand 16 9.78e-01 -3.98e-03 9.95e-01
NCAM signaling for neurite out-growth 47 9.63e-01 -3.96e-03 9.90e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 9.81e-01 3.80e-03 9.96e-01
Early SARS-CoV-2 Infection Events 30 9.72e-01 -3.72e-03 9.93e-01
Laminin interactions 25 9.75e-01 3.67e-03 9.93e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 9.77e-01 3.51e-03 9.94e-01
Arachidonate metabolism 42 9.69e-01 3.48e-03 9.92e-01
Chromatin modifying enzymes 213 9.31e-01 3.45e-03 9.75e-01
Chromatin organization 213 9.31e-01 3.45e-03 9.75e-01
RHOD GTPase cycle 49 9.68e-01 -3.33e-03 9.92e-01
Cristae formation 33 9.74e-01 3.27e-03 9.93e-01
Activated NTRK2 signals through RAS 6 9.89e-01 -3.26e-03 9.98e-01
Activated NTRK3 signals through RAS 6 9.89e-01 -3.26e-03 9.98e-01
Transcriptional Regulation by NPAS4 27 9.78e-01 -3.09e-03 9.95e-01
Eukaryotic Translation Termination 92 9.60e-01 3.02e-03 9.90e-01
tRNA modification in the nucleus and cytosol 43 9.74e-01 2.84e-03 9.93e-01
DNA Damage Reversal 8 9.89e-01 -2.71e-03 9.98e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 9.64e-01 2.62e-03 9.90e-01
PPARA activates gene expression 105 9.65e-01 -2.45e-03 9.91e-01
SUMOylation 167 9.60e-01 2.23e-03 9.90e-01
Negative regulation of MAPK pathway 42 9.83e-01 -1.95e-03 9.96e-01
activated TAK1 mediates p38 MAPK activation 23 9.87e-01 -1.90e-03 9.98e-01
Dual Incision in GG-NER 41 9.85e-01 1.74e-03 9.97e-01
Diseases of branched-chain amino acid catabolism 13 9.91e-01 -1.74e-03 9.99e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 9.87e-01 1.70e-03 9.98e-01
Regulation of IFNG signaling 14 9.93e-01 1.37e-03 9.99e-01
B-WICH complex positively regulates rRNA expression 45 9.88e-01 1.28e-03 9.98e-01
NFE2L2 regulating MDR associated enzymes 8 9.95e-01 -1.21e-03 9.99e-01
Regulation of lipid metabolism by PPARalpha 107 9.83e-01 -1.19e-03 9.96e-01
Negative regulation of FGFR3 signaling 21 9.93e-01 1.18e-03 9.99e-01
FGFR1c ligand binding and activation 8 9.95e-01 1.15e-03 9.99e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 9.91e-01 -1.13e-03 9.99e-01
Long-term potentiation 14 9.95e-01 1.04e-03 9.99e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 9.95e-01 -1.03e-03 9.99e-01
alpha-linolenic acid (ALA) metabolism 12 9.95e-01 -1.03e-03 9.99e-01
Calnexin/calreticulin cycle 26 9.94e-01 8.73e-04 9.99e-01
Insulin receptor signalling cascade 40 9.95e-01 5.56e-04 9.99e-01
HCMV Late Events 67 9.97e-01 3.06e-04 9.99e-01
Glycerophospholipid biosynthesis 104 9.96e-01 -2.49e-04 9.99e-01
ABC transporters in lipid homeostasis 14 9.99e-01 -1.55e-04 1.00e+00
Bacterial Infection Pathways 65 9.98e-01 1.38e-04 1.00e+00
Sensory processing of sound by outer hair cells of the cochlea 40 9.99e-01 -1.20e-04 1.00e+00
Protein hydroxylation 17 1.00e+00 -2.22e-05 1.00e+00


Detailed Gene set reports



CD22 mediated BCR regulation
set CD22 mediated BCR regulation
setSize 58
pANOVA 1.07e-26
s.dist -0.811
p.adjustANOVA 4.12e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGHV3-7 -10642
IGKV3D-20 -10230
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGHV3-11 -9041
CD79B -8653
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
PTPN6 -7124
IGHM -7076
IGKV2-30 -6949
CD79A -3749
LYN -2495
CD22 -2198
IGKV2D-28 -2089
IGHV3-53 1694
IGHD 3268


Phosphorylation of Emi1
set Phosphorylation of Emi1
setSize 6
pANOVA 0.000914
s.dist -0.782
p.adjustANOVA 0.0149


Top enriched genes
Top 20 genes
GeneID Gene Rank
CDC20 -11528
CCNB1 -11322
PLK1 -11300
CDK1 -11296
FBXO5 -7220
FZR1 -3076

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC20 -11528
CCNB1 -11322
PLK1 -11300
CDK1 -11296
FBXO5 -7220
FZR1 -3076


Scavenging of heme from plasma
set Scavenging of heme from plasma
setSize 70
pANOVA 2.38e-29
s.dist -0.776
p.adjustANOVA 2.29e-26


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
JCHAIN -11608
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGHA1 -11558
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
JCHAIN -11608
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGHA1 -11558
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
HP -11308
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
APOL1 -11166
IGHV1-2 -11148
IGKV1-12 -11116
IGHA2 -11088
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
HBB -6735
HBA1 -6604
IGLV4-60 -5437
IGLV2-18 -3740
IGKV2D-28 -2089
LRP1 1591
IGHV3-53 1694
HPX 4253
IGLV10-54 9280
CD163 9558


FCGR activation
set FCGR activation
setSize 76
pANOVA 2.9e-31
s.dist -0.77
p.adjustANOVA 5.56e-28


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
FCGR1A -10433
IGKV3D-20 -10230
IGHG3 -10103
IGLV3-27 -9891
IGHV2-70 -9828
CD3G -9755
IGHV1-69 -9498
IGLV8-61 -9329
HCK -9153
IGLV3-12 -9137
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
YES1 -8282
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
FGR -6997
IGKV2-30 -6949
IGLV4-60 -5437
FYN -4892
IGLV2-18 -3740
LYN -2495
IGKV2D-28 -2089
FCGR3A 1378
IGHV3-53 1694
SYK 3657
FCGR2A 6461
IGLV10-54 9280


Classical antibody-mediated complement activation
set Classical antibody-mediated complement activation
setSize 69
pANOVA 2.86e-27
s.dist -0.752
p.adjustANOVA 1.83e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
IGLV4-60 -5437
IGLV2-18 -3740
IGKV2D-28 -2089
C1QB -1974
C1QA 1074
IGHV3-53 1694
C1S 4431
C1QC 6396
C1R 6798
IGLV10-54 9280


G2/M DNA replication checkpoint
set G2/M DNA replication checkpoint
setSize 5
pANOVA 0.00364
s.dist -0.751
p.adjustANOVA 0.0427


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCNB1 -11322
CDK1 -11296
CCNB2 -10941
WEE1 -6116
PKMYT1 -5141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNB1 -11322
CDK1 -11296
CCNB2 -10941
WEE1 -6116
PKMYT1 -5141


Type I hemidesmosome assembly
set Type I hemidesmosome assembly
setSize 8
pANOVA 0.000399
s.dist -0.723
p.adjustANOVA 0.00759


Top enriched genes
Top 20 genes
GeneID Gene Rank
KRT5 -11613
LAMB3 -11335
CD151 -11325
COL17A1 -11298
ITGB4 -10956
ITGA6 -9002
DST -7445
PLEC 3654

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KRT5 -11613
LAMB3 -11335
CD151 -11325
COL17A1 -11298
ITGB4 -10956
ITGA6 -9002
DST -7445
PLEC 3654


Creation of C4 and C2 activators
set Creation of C4 and C2 activators
setSize 71
pANOVA 1.08e-25
s.dist -0.718
p.adjustANOVA 2.31e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
IGLV4-60 -5437
IGLV2-18 -3740
IGKV2D-28 -2089
C1QB -1974
FCN1 -834
C1QA 1074
IGHV3-53 1694
C1S 4431
C1QC 6396
C1R 6798
MASP2 8365
IGLV10-54 9280


Role of LAT2/NTAL/LAB on calcium mobilization
set Role of LAT2/NTAL/LAB on calcium mobilization
setSize 77
pANOVA 2.71e-25
s.dist -0.684
p.adjustANOVA 5.21e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
MS4A2 -11568
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
MS4A2 -11568
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
IGLV7-43 -11283
FCER1A -11252
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
PIK3R2 -8876
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
LAT2 -5501
IGLV4-60 -5437
FYN -4892
SHC1 -4736
IGLV2-18 -3740
LYN -2495
FCER1G -2397
IGKV2D-28 -2089
IGHE -2053
PIK3CA -1370
PDPK1 -496
SOS1 -481
PIK3CB 829
GRB2 843
IGHV3-53 1694
GAB2 2986
SYK 3657
PIK3R1 4048
IGLV10-54 9280


Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
set Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
setSize 5
pANOVA 0.00949
s.dist -0.67
p.adjustANOVA 0.0835


Top enriched genes
Top 20 genes
GeneID Gene Rank
PROC -11246
GAS6 -9840
PROS1 -9358
BGLAP -8127
PROZ -1943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROC -11246
GAS6 -9840
PROS1 -9358
BGLAP -8127
PROZ -1943


Unwinding of DNA
set Unwinding of DNA
setSize 12
pANOVA 6.07e-05
s.dist -0.668
p.adjustANOVA 0.00153


Top enriched genes
Top 20 genes
GeneID Gene Rank
CDC45 -11537
MCM2 -11238
MCM4 -11128
GINS2 -11117
MCM6 -11110
MCM3 -10497
GINS4 -9642
MCM8 -7299
GINS3 -5252
GINS1 -4465
MCM5 -3361
MCM7 -390

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC45 -11537
MCM2 -11238
MCM4 -11128
GINS2 -11117
MCM6 -11110
MCM3 -10497
GINS4 -9642
MCM8 -7299
GINS3 -5252
GINS1 -4465
MCM5 -3361
MCM7 -390


Activation of NIMA Kinases NEK9, NEK6, NEK7
set Activation of NIMA Kinases NEK9, NEK6, NEK7
setSize 7
pANOVA 0.00231
s.dist -0.665
p.adjustANOVA 0.0302


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCNB1 -11322
PLK1 -11300
CDK1 -11296
CCNB2 -10941
NEK9 -7395
NEK6 -3137
NEK7 -967

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNB1 -11322
PLK1 -11300
CDK1 -11296
CCNB2 -10941
NEK9 -7395
NEK6 -3137
NEK7 -967


Initial triggering of complement
set Initial triggering of complement
setSize 79
pANOVA 7.12e-23
s.dist -0.64
p.adjustANOVA 7.6e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
C3 -11175
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
GZMM -8454
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
IGLV4-60 -5437
IGLV2-18 -3740
CFD -2714
IGKV2D-28 -2089
C1QB -1974
FCN1 -834
C4A 260
C1QA 1074
IGHV3-53 1694
CFB 2443
C2 2653
C1S 4431
C1QC 6396
C1R 6798
CFP 6809
C4B 7083
MASP2 8365
IGLV10-54 9280


FCERI mediated Ca+2 mobilization
set FCERI mediated Ca+2 mobilization
setSize 92
pANOVA 3.01e-25
s.dist -0.625
p.adjustANOVA 5.26e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
MS4A2 -11568
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
MS4A2 -11568
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
IGLV7-43 -11283
FCER1A -11252
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
CALM1 -11118
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
TXK -10768
IGLV1-36 -10669
IGHV3-7 -10642
LAT -10308
IGKV3D-20 -10230
GRAP2 -10014
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
VAV1 -9251
IGLV3-12 -9137
IGHV3-11 -9041
NFATC2 -8980
NFATC3 -8625
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
ITK -7405
IGLV6-57 -7222
BTK -7019
IGKV2-30 -6949
PLCG1 -6230
ITPR3 -5954
VAV2 -5917
PPP3CB -5649
IGLV4-60 -5437
SHC1 -4736
IGLV2-18 -3740
NFATC1 -3360
PLCG2 -3182
LYN -2495
FCER1G -2397
IGKV2D-28 -2089
IGHE -2053
SOS1 -481
ITPR2 -74
PPP3R1 380
GRB2 843
IGHV3-53 1694
AHCYL1 2735
ITPR1 3431
SYK 3657
PPP3CA 4706
LCP2 6834
VAV3 8119
TEC 8467
IGLV10-54 9280


FCGR3A-mediated IL10 synthesis
set FCGR3A-mediated IL10 synthesis
setSize 99
pANOVA 7.03e-27
s.dist -0.624
p.adjustANOVA 3.38e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
CALM1 -11118
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
PRKAR1B -10511
FCGR1A -10433
IGKV3D-20 -10230
IGHG3 -10103
IGLV3-27 -9891
PRKX -9884
IGHV2-70 -9828
CD3G -9755
IGHV1-69 -9498
IGLV8-61 -9329
ADCY3 -9201
HCK -9153
IGLV3-12 -9137
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
YES1 -8282
IGHV3-30 -8180
PRKACB -7974
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
FGR -6997
IGKV2-30 -6949
PRKAR2A -6869
PLCG1 -6230
ITPR3 -5954
PRKAR1A -5769
IGLV4-60 -5437
FYN -4892
PRKAR2B -4664
ADCY5 -3839
IGLV2-18 -3740
PLCG2 -3182
LYN -2495
ADCY7 -2201
IGKV2D-28 -2089
PRKACA -1063
ITPR2 -74
ADCY6 1113
FCGR3A 1378
IGHV3-53 1694
ADCY9 2723
AHCYL1 2735
ADCY2 3216
ITPR1 3431
SYK 3657
CREB1 5137
IL10 6281
FCGR2A 6461
ADCY4 8287
IGLV10-54 9280


Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
set Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
setSize 83
pANOVA 9e-23
s.dist -0.623
p.adjustANOVA 9.1e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGHV1-2 -11148
CALM1 -11118
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
ORAI2 -10749
IGHV3-7 -10642
IGKV3D-20 -10230
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
VAV1 -9251
IGHV3-11 -9041
CD79B -8653
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
PTPN6 -7124
IGHM -7076
BTK -7019
PIK3CD -6951
IGKV2-30 -6949
STIM1 -6512
BLNK -6422
ITPR3 -5954
FYN -4892
SH3KBP1 -4617
PIK3AP1 -4569
ORAI1 -4383
CD79A -3749
PLCG2 -3182
LYN -2495
DAPP1 -2224
BLK -2217
CD22 -2198
IGKV2D-28 -2089
SOS1 -481
ITPR2 -74
CD19 -7
GRB2 843
NCK1 1009
TRPC1 1256
IGHV3-53 1694
AHCYL1 2735
IGHD 3268
ITPR1 3431
SYK 3657
PIK3R1 4048


Role of phospholipids in phagocytosis
set Role of phospholipids in phagocytosis
setSize 88
pANOVA 5.73e-24
s.dist -0.622
p.adjustANOVA 6.88e-22


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
PLD4 -11531
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
PLD4 -11531
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
FCGR1A -10433
IGKV3D-20 -10230
PLA2G6 -10202
IGHG3 -10103
IGLV3-27 -9891
IGHV2-70 -9828
CD3G -9755
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
PIK3R2 -8876
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
PLCG1 -6230
PLD1 -6022
ITPR3 -5954
IGLV4-60 -5437
IGLV2-18 -3740
PLCG2 -3182
IGKV2D-28 -2089
PRKCD -1828
PIK3CA -1370
ITPR2 -74
PIK3CB 829
FCGR3A 1378
IGHV3-53 1694
AHCYL1 2735
ITPR1 3431
SYK 3657
PIK3R1 4048
PLPP5 5813
FCGR2A 6461
PLD2 8375
PRKCE 8837
PLD3 9260
IGLV10-54 9280


Maturation of protein 3a_9683673
set Maturation of protein 3a_9683673
setSize 9
pANOVA 0.00206
s.dist -0.593
p.adjustANOVA 0.028


Top enriched genes
Top 20 genes
GeneID Gene Rank
ST3GAL4 -11365
ST6GALNAC4 -10141
ST3GAL2 -9552
GALNT1 -8150
ST6GAL1 -8102
ST6GALNAC2 -4977
ST3GAL1 -4946
ST6GALNAC3 -4607
ST3GAL3 -3753

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ST3GAL4 -11365
ST6GALNAC4 -10141
ST3GAL2 -9552
GALNT1 -8150
ST6GAL1 -8102
ST6GALNAC2 -4977
ST3GAL1 -4946
ST6GALNAC3 -4607
ST3GAL3 -3753


Maturation of protein 3a_9694719
set Maturation of protein 3a_9694719
setSize 9
pANOVA 0.00206
s.dist -0.593
p.adjustANOVA 0.028


Top enriched genes
Top 20 genes
GeneID Gene Rank
ST3GAL4 -11365
ST6GALNAC4 -10141
ST3GAL2 -9552
GALNT1 -8150
ST6GAL1 -8102
ST6GALNAC2 -4977
ST3GAL1 -4946
ST6GALNAC3 -4607
ST3GAL3 -3753

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ST3GAL4 -11365
ST6GALNAC4 -10141
ST3GAL2 -9552
GALNT1 -8150
ST6GAL1 -8102
ST6GALNAC2 -4977
ST3GAL1 -4946
ST6GALNAC3 -4607
ST3GAL3 -3753


Interleukin-21 signaling
set Interleukin-21 signaling
setSize 9
pANOVA 0.00208
s.dist -0.593
p.adjustANOVA 0.0281


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAT1 -11304
IL2RG -11159
JAK3 -11139
IL21R -10976
STAT4 -8660
JAK1 -4992
STAT3 -4665
STAT5A -1985
STAT5B -653

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT1 -11304
IL2RG -11159
JAK3 -11139
IL21R -10976
STAT4 -8660
JAK1 -4992
STAT3 -4665
STAT5A -1985
STAT5B -653


Binding and Uptake of Ligands by Scavenger Receptors
set Binding and Uptake of Ligands by Scavenger Receptors
setSize 90
pANOVA 3.8e-22
s.dist -0.59
p.adjustANOVA 3.65e-20


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
JCHAIN -11608
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGHA1 -11558
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
JCHAIN -11608
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGHA1 -11558
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
HP -11308
IGLV7-43 -11283
CD36 -11281
IGHV3-13 -11199
IGLV4-69 -11194
APOL1 -11166
IGHV1-2 -11148
IGKV1-12 -11116
IGHA2 -11088
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
HYOU1 -10189
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
SCARB1 -7790
IGHV3-48 -7667
SPARC -7312
IGLV6-57 -7222
IGKV2-30 -6949
HBB -6735
STAB2 -6685
HBA1 -6604
HSP90B1 -6236
IGLV4-60 -5437
CALR -4984
HSP90AA1 -4903
HSPH1 -4104
IGLV2-18 -3740
IGKV2D-28 -2089
SCGB3A2 -106
LRP1 1591
IGHV3-53 1694
SSC5D 2534
SCARF1 2805
APOE 3114
HPX 4253
COLEC12 4539
FTH1 5225
FTL 6449
STAB1 7187
MARCO 7363
IGLV10-54 9280
MSR1 9311
COL4A2 9474
CD163 9558


PI3K events in ERBB4 signaling
set PI3K events in ERBB4 signaling
setSize 6
pANOVA 0.0145
s.dist 0.576
p.adjustANOVA 0.117


Top enriched genes
Top 20 genes
GeneID Gene Rank
EREG 9382
NRG4 7668
HBEGF 6723
NRG1 4348
PIK3R1 4048
PIK3CA -1370

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EREG 9382
NRG4 7668
HBEGF 6723
NRG1 4348
PIK3R1 4048
PIK3CA -1370


Common Pathway of Fibrin Clot Formation
set Common Pathway of Fibrin Clot Formation
setSize 13
pANOVA 0.000327
s.dist -0.575
p.adjustANOVA 0.00676


Top enriched genes
Top 20 genes
GeneID Gene Rank
PROC -11246
PF4V1 -11142
PRTN3 -11094
PROCR -11038
F2R -10001
F13A1 -9422
PROS1 -9358
SERPINE2 -7881
PF4 -6233
F5 -6168
F8 -3317
THBD -2988
CD177 7617

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROC -11246
PF4V1 -11142
PRTN3 -11094
PROCR -11038
F2R -10001
F13A1 -9422
PROS1 -9358
SERPINE2 -7881
PF4 -6233
F5 -6168
F8 -3317
THBD -2988
CD177 7617


Neurotransmitter clearance
set Neurotransmitter clearance
setSize 6
pANOVA 0.0165
s.dist 0.565
p.adjustANOVA 0.127


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAOA 9627
ALDH2 9326
SLC22A1 8996
LRTOMT 6111
COMT -796
SLC6A4 -3162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAOA 9627
ALDH2 9326
SLC22A1 8996
LRTOMT 6111
COMT -796
SLC6A4 -3162


Activation of NOXA and translocation to mitochondria
set Activation of NOXA and translocation to mitochondria
setSize 5
pANOVA 0.0293
s.dist -0.563
p.adjustANOVA 0.179


Top enriched genes
Top 20 genes
GeneID Gene Rank
TFDP2 -11541
TFDP1 -11356
E2F1 -9350
TP53 -5090
PMAIP1 2510

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFDP2 -11541
TFDP1 -11356
E2F1 -9350
TP53 -5090
PMAIP1 2510


Protein repair
set Protein repair
setSize 6
pANOVA 0.0171
s.dist -0.562
p.adjustANOVA 0.129


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSRA -11070
MSRB3 -9199
MSRB1 -8506
PCMT1 -6495
TXN -4117
MSRB2 -2356

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSRA -11070
MSRB3 -9199
MSRB1 -8506
PCMT1 -6495
TXN -4117
MSRB2 -2356


FCERI mediated MAPK activation
set FCERI mediated MAPK activation
setSize 93
pANOVA 1.47e-20
s.dist -0.557
p.adjustANOVA 1.28e-18


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
MS4A2 -11568
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
MS4A2 -11568
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGLV2-23 -11321
IGLV7-43 -11283
FCER1A -11252
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
LAT -10308
IGKV3D-20 -10230
GRAP2 -10014
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
IGLV8-61 -9329
VAV1 -9251
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
PLCG1 -6230
VAV2 -5917
IGLV4-60 -5437
FOS -5177
SHC1 -4736
IGLV2-18 -3740
PLCG2 -3182
HRAS -2925
MAPK3 -2796
LYN -2495
MAPK9 -2429
FCER1G -2397
MAPK1 -2156
IGKV2D-28 -2089
IGHE -2053
MAP2K4 -1004
RAC1 -538
SOS1 -481
KRAS 14
MAP2K7 151
GRB2 843
PAK1 988
NRAS 1155
IGHV3-53 1694
JUN 2555
PAK2 2970
SYK 3657
MAPK10 6166
MAPK8 6676
MAP3K1 6766
LCP2 6834
VAV3 8119
IGLV10-54 9280


Synthesis of Ketone Bodies
set Synthesis of Ketone Bodies
setSize 6
pANOVA 0.0182
s.dist -0.557
p.adjustANOVA 0.134


Top enriched genes
Top 20 genes
GeneID Gene Rank
BDH1 -11237
AACS -9735
HMGCL -8222
ACAT1 -6193
BDH2 -3225
ACSS3 -2809

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BDH1 -11237
AACS -9735
HMGCL -8222
ACAT1 -6193
BDH2 -3225
ACSS3 -2809


Regulation of CDH19 Expression and Function
set Regulation of CDH19 Expression and Function
setSize 5
pANOVA 0.032
s.dist 0.554
p.adjustANOVA 0.186


Top enriched genes
Top 20 genes
GeneID Gene Rank
ZC3H12A 8967
CTNND1 7999
CTNNB1 7518
CTNNA1 1889
JUP -1894

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZC3H12A 8967
CTNND1 7999
CTNNB1 7518
CTNNA1 1889
JUP -1894


FCGR3A-mediated phagocytosis
set FCGR3A-mediated phagocytosis
setSize 121
pANOVA 6.19e-26
s.dist -0.554
p.adjustANOVA 1.49e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
CYFIP2 -11306
IGLV7-43 -11283
MYO10 -11227
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
ACTG1 -11001
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
WASF1 -9997
IGLV3-27 -9891
IGHV2-70 -9828
CD3G -9755
WASF3 -9680
IGHV1-69 -9498
IGLV8-61 -9329
VAV1 -9251
HCK -9153
IGLV3-12 -9137
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
YES1 -8282
ABI2 -8264
ACTB -8257
IGHV3-30 -8180
MYO1C -8174
IGKV3-11 -7831
IGHV3-48 -7667
WAS -7501
MYH9 -7351
IGLV6-57 -7222
BTK -7019
FGR -6997
ARPC4 -6982
IGKV2-30 -6949
ARPC1B -6410
PTK2 -6164
ARPC2 -6015
WIPF2 -5996
VAV2 -5917
ARPC1A -5907
IGLV4-60 -5437
ACTR3 -5259
WASF2 -5154
FYN -4892
NCKAP1 -4613
ELMO2 -4300
IGLV2-18 -3740
NCKAP1L -3283
MAPK3 -2796
LYN -2495
ARPC5 -2476
MAPK1 -2156
IGKV2D-28 -2089
ABI1 -2001
ACTR2 -1733
CRK -1654
MYO5A -630
ARPC3 -625
RAC1 -538
BRK1 131
NCKIPSD 628
GRB2 843
NCK1 1009
FCGR3A 1378
IGHV3-53 1694
MYO9B 1708
CDC42 1967
DOCK1 2471
WIPF1 2478
SYK 3657
WASL 5862
ELMO1 5919
ABL1 6528
CYFIP1 7168
VAV3 8119
BAIAP2 8569
IGLV10-54 9280


Leishmania phagocytosis
set Leishmania phagocytosis
setSize 121
pANOVA 6.19e-26
s.dist -0.554
p.adjustANOVA 1.49e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
CYFIP2 -11306
IGLV7-43 -11283
MYO10 -11227
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
ACTG1 -11001
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
WASF1 -9997
IGLV3-27 -9891
IGHV2-70 -9828
CD3G -9755
WASF3 -9680
IGHV1-69 -9498
IGLV8-61 -9329
VAV1 -9251
HCK -9153
IGLV3-12 -9137
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
YES1 -8282
ABI2 -8264
ACTB -8257
IGHV3-30 -8180
MYO1C -8174
IGKV3-11 -7831
IGHV3-48 -7667
WAS -7501
MYH9 -7351
IGLV6-57 -7222
BTK -7019
FGR -6997
ARPC4 -6982
IGKV2-30 -6949
ARPC1B -6410
PTK2 -6164
ARPC2 -6015
WIPF2 -5996
VAV2 -5917
ARPC1A -5907
IGLV4-60 -5437
ACTR3 -5259
WASF2 -5154
FYN -4892
NCKAP1 -4613
ELMO2 -4300
IGLV2-18 -3740
NCKAP1L -3283
MAPK3 -2796
LYN -2495
ARPC5 -2476
MAPK1 -2156
IGKV2D-28 -2089
ABI1 -2001
ACTR2 -1733
CRK -1654
MYO5A -630
ARPC3 -625
RAC1 -538
BRK1 131
NCKIPSD 628
GRB2 843
NCK1 1009
FCGR3A 1378
IGHV3-53 1694
MYO9B 1708
CDC42 1967
DOCK1 2471
WIPF1 2478
SYK 3657
WASL 5862
ELMO1 5919
ABL1 6528
CYFIP1 7168
VAV3 8119
BAIAP2 8569
IGLV10-54 9280


Parasite infection
set Parasite infection
setSize 121
pANOVA 6.19e-26
s.dist -0.554
p.adjustANOVA 1.49e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
CYFIP2 -11306
IGLV7-43 -11283
MYO10 -11227
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
ACTG1 -11001
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
WASF1 -9997
IGLV3-27 -9891
IGHV2-70 -9828
CD3G -9755
WASF3 -9680
IGHV1-69 -9498
IGLV8-61 -9329
VAV1 -9251
HCK -9153
IGLV3-12 -9137
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
YES1 -8282
ABI2 -8264
ACTB -8257
IGHV3-30 -8180
MYO1C -8174
IGKV3-11 -7831
IGHV3-48 -7667
WAS -7501
MYH9 -7351
IGLV6-57 -7222
BTK -7019
FGR -6997
ARPC4 -6982
IGKV2-30 -6949
ARPC1B -6410
PTK2 -6164
ARPC2 -6015
WIPF2 -5996
VAV2 -5917
ARPC1A -5907
IGLV4-60 -5437
ACTR3 -5259
WASF2 -5154
FYN -4892
NCKAP1 -4613
ELMO2 -4300
IGLV2-18 -3740
NCKAP1L -3283
MAPK3 -2796
LYN -2495
ARPC5 -2476
MAPK1 -2156
IGKV2D-28 -2089
ABI1 -2001
ACTR2 -1733
CRK -1654
MYO5A -630
ARPC3 -625
RAC1 -538
BRK1 131
NCKIPSD 628
GRB2 843
NCK1 1009
FCGR3A 1378
IGHV3-53 1694
MYO9B 1708
CDC42 1967
DOCK1 2471
WIPF1 2478
SYK 3657
WASL 5862
ELMO1 5919
ABL1 6528
CYFIP1 7168
VAV3 8119
BAIAP2 8569
IGLV10-54 9280


Gamma-carboxylation of protein precursors
set Gamma-carboxylation of protein precursors
setSize 6
pANOVA 0.0198
s.dist -0.549
p.adjustANOVA 0.139


Top enriched genes
Top 20 genes
GeneID Gene Rank
PROC -11246
GAS6 -9840
PROS1 -9358
BGLAP -8127
PROZ -1943
GGCX -427

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROC -11246
GAS6 -9840
PROS1 -9358
BGLAP -8127
PROZ -1943
GGCX -427


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0342
s.dist -0.547
p.adjustANOVA 0.195


Top enriched genes
Top 20 genes
GeneID Gene Rank
TST -9434
TSTD1 -9348
SLC25A10 -8831
SUOX -8598
ETHE1 2226

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TST -9434
TSTD1 -9348
SLC25A10 -8831
SUOX -8598
ETHE1 2226


Regulation of actin dynamics for phagocytic cup formation
set Regulation of actin dynamics for phagocytic cup formation
setSize 123
pANOVA 5.1e-25
s.dist -0.539
p.adjustANOVA 8.16e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
CYFIP2 -11306
IGLV7-43 -11283
MYO10 -11227
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
IGKV1-12 -11116
IGKV1-17 -11068
ACTG1 -11001
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
FCGR1A -10433
IGKV3D-20 -10230
IGHG3 -10103
WASF1 -9997
IGLV3-27 -9891
IGHV2-70 -9828
CD3G -9755
WASF3 -9680
IGHV1-69 -9498
IGLV8-61 -9329
VAV1 -9251
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
ABI2 -8264
ACTB -8257
IGHV3-30 -8180
MYO1C -8174
LIMK1 -7863
IGKV3-11 -7831
IGHV3-48 -7667
NF2 -7660
WAS -7501
MYH9 -7351
CFL1 -7346
IGLV6-57 -7222
BTK -7019
ARPC4 -6982
IGKV2-30 -6949
ARPC1B -6410
PTK2 -6164
ARPC2 -6015
WIPF2 -5996
VAV2 -5917
ARPC1A -5907
IGLV4-60 -5437
ACTR3 -5259
WASF2 -5154
HSP90AA1 -4903
NCKAP1 -4613
HSP90AB1 -4331
ELMO2 -4300
IGLV2-18 -3740
NCKAP1L -3283
MAPK3 -2796
ARPC5 -2476
MAPK1 -2156
IGKV2D-28 -2089
ABI1 -2001
ACTR2 -1733
CRK -1654
MYO5A -630
ARPC3 -625
RAC1 -538
BRK1 131
NCKIPSD 628
GRB2 843
PAK1 988
NCK1 1009
FCGR3A 1378
IGHV3-53 1694
MYO9B 1708
CDC42 1967
DOCK1 2471
WIPF1 2478
SYK 3657
WASL 5862
ELMO1 5919
FCGR2A 6461
ABL1 6528
CYFIP1 7168
VAV3 8119
BAIAP2 8569
IGLV10-54 9280


G1/S-Specific Transcription
set G1/S-Specific Transcription
setSize 29
pANOVA 9.87e-07
s.dist -0.525
p.adjustANOVA 3.72e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
TFDP2 -11541
CDC45 -11537
TYMS -11462
CDC6 -11370
TFDP1 -11356
RRM2 -11344
CDK1 -11296
CDT1 -11247
LIN52 -10690
HDAC1 -10564
TK1 -9757
E2F1 -9350
CCNA1 -9306
CCNE1 -9131
CDC25A -7719
DHFR -7382
RBL2 -7340
FBXO5 -7220
ORC1 -6704
PCNA -6561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFDP2 -11541
CDC45 -11537
TYMS -11462
CDC6 -11370
TFDP1 -11356
RRM2 -11344
CDK1 -11296
CDT1 -11247
LIN52 -10690
HDAC1 -10564
TK1 -9757
E2F1 -9350
CCNA1 -9306
CCNE1 -9131
CDC25A -7719
DHFR -7382
RBL2 -7340
FBXO5 -7220
ORC1 -6704
PCNA -6561
LIN37 -4696
E2F5 -4487
RBL1 -697
POLA1 -290
E2F4 455
RBBP4 723
LIN9 1209
LIN54 2406
E2F6 8074


FGFR1b ligand binding and activation
set FGFR1b ligand binding and activation
setSize 5
pANOVA 0.0423
s.dist -0.524
p.adjustANOVA 0.222


Top enriched genes
Top 20 genes
GeneID Gene Rank
TGFBR3 -9528
FGF22 -7941
GIPC1 -7547
FGF2 -5351
FGFR1 -2419

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGFBR3 -9528
FGF22 -7941
GIPC1 -7547
FGF2 -5351
FGFR1 -2419


Condensation of Prometaphase Chromosomes
set Condensation of Prometaphase Chromosomes
setSize 11
pANOVA 0.00265
s.dist -0.523
p.adjustANOVA 0.033


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCAPG -11427
CCNB1 -11322
CDK1 -11296
NCAPH -11024
CCNB2 -10941
NCAPD2 -9538
SMC2 -7313
SMC4 -2110
CSNK2A1 488
CSNK2B 1237
CSNK2A2 1245

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCAPG -11427
CCNB1 -11322
CDK1 -11296
NCAPH -11024
CCNB2 -10941
NCAPD2 -9538
SMC2 -7313
SMC4 -2110
CSNK2A1 488
CSNK2B 1237
CSNK2A2 1245


Regulation of Complement cascade
set Regulation of Complement cascade
setSize 96
pANOVA 3.48e-18
s.dist -0.513
p.adjustANOVA 2.48e-16


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
CLU -11233
IGHV3-13 -11199
IGLV4-69 -11194
C3 -11175
IGHV1-2 -11148
CD59 -11131
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CR1 -10953
IGHV1-46 -10951
CD55 -10940
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
ELANE -10069
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
PROS1 -9358
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
SERPING1 -8361
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
CD81 -6504
IGLV4-60 -5437
IGLV2-18 -3740
CR2 -2204
IGKV2D-28 -2089
C1QB -1974
C4BPB -537
CD19 -7
C4A 260
C1QA 1074
C8G 1413
IGHV3-53 1694
CFB 2443
C2 2653
C1S 4431
C5 6148
C1QC 6396
C4BPA 6762
C1R 6798
CFP 6809
C4B 7083
CD46 7572
C5AR2 8167
VTN 8693
CFH 8890
C5AR1 9064
CPN2 9104
IGLV10-54 9280
C3AR1 9373


Anti-inflammatory response favouring Leishmania parasite infection
set Anti-inflammatory response favouring Leishmania parasite infection
setSize 131
pANOVA 3.3e-24
s.dist -0.513
p.adjustANOVA 4.53e-22


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
CALM1 -11118
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
GNAS -10547
PRKAR1B -10511
FCGR1A -10433
ADORA2B -10354
IGKV3D-20 -10230
GGT1 -10159
GNG8 -10116
IGHG3 -10103
GNG7 -10038
IGLV3-27 -9891
PRKX -9884
IGHV2-70 -9828
CD3G -9755
IGHV1-69 -9498
IGLV8-61 -9329
GNAI1 -9287
GNB3 -9279
ADCY3 -9201
HCK -9153
IGLV3-12 -9137
GNG2 -9130
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
GNG11 -8423
CYSLTR1 -8306
YES1 -8282
IGHV3-30 -8180
MAPK14 -8001
PRKACB -7974
IGKV3-11 -7831
IGHV3-48 -7667
MYH9 -7351
IGLV6-57 -7222
FGR -6997
IGKV2-30 -6949
PRKAR2A -6869
GGT5 -6454
PLCG1 -6230
ITPR3 -5954
PRKAR1A -5769
IGLV4-60 -5437
GNB2 -5142
FYN -4892
PRKAR2B -4664
ADCY5 -3839
IGLV2-18 -3740
PLCG2 -3182
CYSLTR2 -3043
GNAZ -3021
LYN -2495
GNG10 -2265
ADCY7 -2201
GNB1 -2167
IGKV2D-28 -2089
GNAI2 -1714
GNB4 -1325
GNG4 -1130
PRKACA -1063
GNB5 -387
ITPR2 -74
GNGT2 833
GNAI3 1040
ADCY6 1113
FCGR3A 1378
RHBDF2 1576
IGHV3-53 1694
GNG5 2274
ADCY9 2723
AHCYL1 2735
ADCY2 3216
ITPR1 3431
SYK 3657
DPEP2 4493
FURIN 4766
CREB1 5137
IL10 6281
FCGR2A 6461
GNG3 7076
ADAM17 8047
ADCY4 8287
IGLV10-54 9280
PLK2 9543
CD163 9558


Leishmania parasite growth and survival
set Leishmania parasite growth and survival
setSize 131
pANOVA 3.3e-24
s.dist -0.513
p.adjustANOVA 4.53e-22


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
IGHV3-13 -11199
IGLV4-69 -11194
IGHV1-2 -11148
CALM1 -11118
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CD247 -10966
IGHV1-46 -10951
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
GNAS -10547
PRKAR1B -10511
FCGR1A -10433
ADORA2B -10354
IGKV3D-20 -10230
GGT1 -10159
GNG8 -10116
IGHG3 -10103
GNG7 -10038
IGLV3-27 -9891
PRKX -9884
IGHV2-70 -9828
CD3G -9755
IGHV1-69 -9498
IGLV8-61 -9329
GNAI1 -9287
GNB3 -9279
ADCY3 -9201
HCK -9153
IGLV3-12 -9137
GNG2 -9130
SRC -9043
IGHV3-11 -9041
IGKV2-29 -8556
GNG11 -8423
CYSLTR1 -8306
YES1 -8282
IGHV3-30 -8180
MAPK14 -8001
PRKACB -7974
IGKV3-11 -7831
IGHV3-48 -7667
MYH9 -7351
IGLV6-57 -7222
FGR -6997
IGKV2-30 -6949
PRKAR2A -6869
GGT5 -6454
PLCG1 -6230
ITPR3 -5954
PRKAR1A -5769
IGLV4-60 -5437
GNB2 -5142
FYN -4892
PRKAR2B -4664
ADCY5 -3839
IGLV2-18 -3740
PLCG2 -3182
CYSLTR2 -3043
GNAZ -3021
LYN -2495
GNG10 -2265
ADCY7 -2201
GNB1 -2167
IGKV2D-28 -2089
GNAI2 -1714
GNB4 -1325
GNG4 -1130
PRKACA -1063
GNB5 -387
ITPR2 -74
GNGT2 833
GNAI3 1040
ADCY6 1113
FCGR3A 1378
RHBDF2 1576
IGHV3-53 1694
GNG5 2274
ADCY9 2723
AHCYL1 2735
ADCY2 3216
ITPR1 3431
SYK 3657
DPEP2 4493
FURIN 4766
CREB1 5137
IL10 6281
FCGR2A 6461
GNG3 7076
ADAM17 8047
ADCY4 8287
IGLV10-54 9280
PLK2 9543
CD163 9558


ROBO receptors bind AKAP5
set ROBO receptors bind AKAP5
setSize 7
pANOVA 0.0192
s.dist -0.511
p.adjustANOVA 0.137


Top enriched genes
Top 20 genes
GeneID Gene Rank
AKAP5 -10912
PRKCA -10820
PRKACB -7974
PRKAR2A -6869
PPP3CB -5649
ROBO3 -1633
PRKACA -1063

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKAP5 -10912
PRKCA -10820
PRKACB -7974
PRKAR2A -6869
PPP3CB -5649
ROBO3 -1633
PRKACA -1063


FGFR2b ligand binding and activation
set FGFR2b ligand binding and activation
setSize 6
pANOVA 0.0314
s.dist -0.507
p.adjustANOVA 0.185


Top enriched genes
Top 20 genes
GeneID Gene Rank
FGFBP2 -11249
FGF22 -7941
FGFBP3 -6986
FGF2 -5351
FGF7 -4145
FGFR2 -2584

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGFBP2 -11249
FGF22 -7941
FGFBP3 -6986
FGF2 -5351
FGF7 -4145
FGFR2 -2584


Hydrolysis of LPC
set Hydrolysis of LPC
setSize 8
pANOVA 0.0135
s.dist 0.504
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPCPD1 8616
PLA2G4D 7530
PLA2G4B 7116
PLA2G15 5694
PLA2G4F 5514
PLBD1 4420
PLA2G4C -1668
PLA2G4A -2261

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPCPD1 8616
PLA2G4D 7530
PLA2G4B 7116
PLA2G15 5694
PLA2G4F 5514
PLBD1 4420
PLA2G4C -1668
PLA2G4A -2261


Regulation of IFNA/IFNB signaling
set Regulation of IFNA/IFNB signaling
setSize 12
pANOVA 0.00258
s.dist -0.502
p.adjustANOVA 0.0328


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAT1 -11304
USP18 -11250
SOCS1 -9871
IFNAR2 -8582
STAT2 -7370
PTPN6 -7124
IFNAR1 -6085
JAK1 -4992
PTPN1 -4820
PTPN11 -3549
SOCS3 -3514
TYK2 2585

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT1 -11304
USP18 -11250
SOCS1 -9871
IFNAR2 -8582
STAT2 -7370
PTPN6 -7124
IFNAR1 -6085
JAK1 -4992
PTPN1 -4820
PTPN11 -3549
SOCS3 -3514
TYK2 2585


Drug-mediated inhibition of CDK4/CDK6 activity
set Drug-mediated inhibition of CDK4/CDK6 activity
setSize 5
pANOVA 0.0533
s.dist -0.499
p.adjustANOVA 0.249


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCND2 -10836
CCND3 -9606
CDK4 -8500
CCND1 -5709
CDK6 3209

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCND2 -10836
CCND3 -9606
CDK4 -8500
CCND1 -5709
CDK6 3209


Uptake of dietary cobalamins into enterocytes
set Uptake of dietary cobalamins into enterocytes
setSize 5
pANOVA 0.0536
s.dist -0.498
p.adjustANOVA 0.249


Top enriched genes
Top 20 genes
GeneID Gene Rank
TCN1 -11469
CUBN -9946
ABCD4 -9679
AMN -788
LMBRD1 470

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCN1 -11469
CUBN -9946
ABCD4 -9679
AMN -788
LMBRD1 470


Ketone body metabolism
set Ketone body metabolism
setSize 8
pANOVA 0.0148
s.dist -0.498
p.adjustANOVA 0.118


Top enriched genes
Top 20 genes
GeneID Gene Rank
BDH1 -11237
OXCT1 -10470
AACS -9735
HMGCL -8222
ACAT1 -6193
BDH2 -3225
ACSS3 -2809
OXCT2 1692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BDH1 -11237
OXCT1 -10470
AACS -9735
HMGCL -8222
ACAT1 -6193
BDH2 -3225
ACSS3 -2809
OXCT2 1692


Transcription of E2F targets under negative control by DREAM complex
set Transcription of E2F targets under negative control by DREAM complex
setSize 19
pANOVA 0.000197
s.dist -0.493
p.adjustANOVA 0.0043


Top enriched genes
Top 20 genes
GeneID Gene Rank
TOP2A -11567
TFDP2 -11541
CDC6 -11370
TFDP1 -11356
LIN52 -10690
HDAC1 -10564
E2F1 -9350
MAX -8321
CDC25A -7719
RBL2 -7340
MYC -6796
PCNA -6561
LIN37 -4696
E2F5 -4487
RBL1 -697
E2F4 455
RBBP4 723
LIN9 1209
LIN54 2406

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TOP2A -11567
TFDP2 -11541
CDC6 -11370
TFDP1 -11356
LIN52 -10690
HDAC1 -10564
E2F1 -9350
MAX -8321
CDC25A -7719
RBL2 -7340
MYC -6796
PCNA -6561
LIN37 -4696
E2F5 -4487
RBL1 -697
E2F4 455
RBBP4 723
LIN9 1209
LIN54 2406


Complement cascade
set Complement cascade
setSize 100
pANOVA 1.68e-17
s.dist -0.492
p.adjustANOVA 1.15e-15


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-28 -11612
IGLV1-51 -11607
IGLV1-47 -11606
IGLC2 -11602
IGLV3-25 -11598
IGKV4-1 -11588
IGKV3-20 -11586
IGKV3-15 -11574
IGLC1 -11563
IGLV1-40 -11561
IGHV4-59 -11559
IGLV2-8 -11543
IGHG1 -11542
IGLV3-1 -11534
IGKC -11532
IGLV3-21 -11522
IGLV3-19 -11509
IGHV4-39 -11507
IGHG4 -11500
IGKV1D-39 -11499
IGKV1-5 -11494
IGHV3-23 -11454
IGLV1-44 -11452
IGLV2-14 -11446
IGHV2-5 -11394
IGKV1-16 -11384
IGHV4-34 -11382
IGLV5-45 -11373
IGKV5-2 -11355
IGLC3 -11349
IGHG2 -11334
IGLV2-23 -11321
IGLV7-43 -11283
CLU -11233
IGHV3-13 -11199
IGLV4-69 -11194
C3 -11175
IGHV1-2 -11148
CD59 -11131
IGKV1-12 -11116
IGKV1-17 -11068
IGHV3-33 -10995
CR1 -10953
IGHV1-46 -10951
CD55 -10940
IGLV2-11 -10902
IGKV1-33 -10894
IGLV7-46 -10777
IGLV1-36 -10669
IGHV3-7 -10642
IGKV3D-20 -10230
IGHG3 -10103
ELANE -10069
IGLV3-27 -9891
IGHV2-70 -9828
IGHV1-69 -9498
PROS1 -9358
IGLV8-61 -9329
IGLV3-12 -9137
IGHV3-11 -9041
IGKV2-29 -8556
GZMM -8454
SERPING1 -8361
IGHV3-30 -8180
IGKV3-11 -7831
IGHV3-48 -7667
IGLV6-57 -7222
IGKV2-30 -6949
CD81 -6504
IGLV4-60 -5437
IGLV2-18 -3740
CFD -2714
CR2 -2204
IGKV2D-28 -2089
C1QB -1974
FCN1 -834
C4BPB -537
CD19 -7
C4A 260
C1QA 1074
C8G 1413
IGHV3-53 1694
CFB 2443
C2 2653
C1S 4431
C5 6148
C1QC 6396
C4BPA 6762
C1R 6798
CFP 6809
C4B 7083
CD46 7572
C5AR2 8167
MASP2 8365
VTN 8693
CFH 8890
C5AR1 9064
CPN2 9104
IGLV10-54 9280
C3AR1 9373


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Expression and translocation of olfactory receptors`
## [1] "OR2B11" "OR2M4" 
## 
## [[1]]$`UP genesets.FASTK family proteins regulate processing and stability of mitochondrial RNAs`
## [1] "MT-CO1"
## 
## [[1]]$`UP genesets.Heme signaling`
## character(0)
## 
## [[1]]$`UP genesets.Interleukin-10 signaling`
## [1] "CCL20"  "CCL3"   "CCL3L1" "CXCL2"  "CXCL8"  "IL1B"   "IL1R2" 
## 
## [[1]]$`UP genesets.Mitochondrial RNA degradation`
## [1] "MT-CO1"
## 
## [[1]]$`UP genesets.tRNA processing in the mitochondrion`
## [1] "MT-CO1" "MT-TP" 
## 
## [[1]]$`DOWN genesets.Activation of NIMA Kinases NEK9, NEK6, NEK7`
## [1] "CCNB1" "CCNB2" "CDK1"  "NEK6"  "NEK7"  "NEK9"  "PLK1" 
## 
## [[1]]$`DOWN genesets.Antigen activates B Cell Receptor (BCR) leading to generation of second messengers`
##  [1] "AHCYL1"    "BLK"       "BLNK"      "BTK"       "CALM1"     "CD19"     
##  [7] "CD22"      "CD79A"     "CD79B"     "DAPP1"     "FYN"       "GRB2"     
## [13] "IGHD"      "IGHM"      "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"  
## [19] "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33" 
## [25] "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59" 
## [31] "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"  
## [37] "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11" 
## [43] "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGKV5-2"   "IGLC1"    
## [49] "IGLC2"     "IGLC3"     "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51" 
## [55] "IGLV2-11"  "IGLV2-14"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-19" 
## [61] "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV6-57"  "IGLV7-43"  "ITPR1"    
## [67] "ITPR2"     "ITPR3"     "LYN"       "NCK1"      "ORAI1"     "ORAI2"    
## [73] "PIK3AP1"   "PIK3CD"    "PIK3R1"    "PLCG2"     "PTPN6"     "SH3KBP1"  
## [79] "SOS1"      "STIM1"     "SYK"       "TRPC1"     "VAV1"     
## 
## [[1]]$`DOWN genesets.Binding and Uptake of Ligands by Scavenger Receptors`
##  [1] "APOE"      "APOL1"     "CALR"      "CD36"      "COLEC12"   "FTH1"     
##  [7] "FTL"       "HBA1"      "HBB"       "HP"        "HPX"       "HSP90AA1" 
## [13] "HSP90B1"   "HSPH1"     "HYOU1"     "IGHA1"     "IGHA2"     "IGHV1-2"  
## [19] "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13" 
## [25] "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"  
## [31] "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16" 
## [37] "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29" 
## [43] "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20"
## [49] "IGKV4-1"   "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLV1-36" 
## [55] "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14" 
## [61] "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19" 
## [67] "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45" 
## [73] "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "JCHAIN"    "LRP1"     
## [79] "MARCO"     "SCARB1"    "SCARF1"    "SCGB3A2"   "SPARC"     "SSC5D"    
## [85] "STAB1"     "STAB2"    
## 
## [[1]]$`DOWN genesets.CD22 mediated BCR regulation`
##  [1] "CD22"      "CD79A"     "CD79B"     "IGHD"      "IGHM"      "IGHV1-2"  
##  [7] "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13" 
## [13] "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"  
## [19] "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16" 
## [25] "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29" 
## [31] "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20"
## [37] "IGKV4-1"   "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLV1-40" 
## [43] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-23" 
## [49] "IGLV2-8"   "IGLV3-1"   "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27" 
## [55] "IGLV6-57"  "IGLV7-43"  "LYN"       "PTPN6"    
## 
## [[1]]$`DOWN genesets.Classical antibody-mediated complement activation`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "IGHG1"    
##  [7] "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46"  "IGHV1-69" 
## [13] "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30" 
## [19] "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39" 
## [25] "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33" 
## [31] "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28"
## [37] "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGKV5-2"  
## [43] "IGLC1"     "IGLC2"     "IGLC3"     "IGLV1-36"  "IGLV1-40"  "IGLV1-44" 
## [49] "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-18"  "IGLV2-23" 
## [55] "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21"  "IGLV3-25" 
## [61] "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57"  "IGLV7-43" 
## [67] "IGLV7-46"  "IGLV8-61" 
## 
## [[1]]$`DOWN genesets.Creation of C4 and C2 activators`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "FCN1"     
##  [7] "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46" 
## [13] "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23" 
## [19] "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34" 
## [25] "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17" 
## [31] "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30" 
## [37] "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"  
## [43] "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLV1-36"  "IGLV1-40" 
## [49] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-18" 
## [55] "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21" 
## [61] "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57" 
## [67] "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "MASP2"    
## 
## [[1]]$`DOWN genesets.FCERI mediated Ca+2 mobilization`
##  [1] "AHCYL1"    "BTK"       "CALM1"     "FCER1A"    "FCER1G"    "GRAP2"    
##  [7] "GRB2"      "IGHE"      "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"  
## [13] "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33" 
## [19] "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59" 
## [25] "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"  
## [31] "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11" 
## [37] "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGKV5-2"   "IGLC1"    
## [43] "IGLC2"     "IGLC3"     "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47" 
## [49] "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"  
## [55] "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27" 
## [61] "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46" 
## [67] "IGLV8-61"  "ITK"       "ITPR1"     "ITPR2"     "ITPR3"     "LAT"      
## [73] "LCP2"      "LYN"       "MS4A2"     "NFATC1"    "NFATC2"    "NFATC3"   
## [79] "PLCG1"     "PLCG2"     "PPP3CA"    "PPP3CB"    "PPP3R1"    "SHC1"     
## [85] "SOS1"      "SYK"       "TEC"       "TXK"       "VAV1"      "VAV2"     
## [91] "VAV3"     
## 
## [[1]]$`DOWN genesets.FCGR activation`
##  [1] "CD247"     "CD3G"      "FCGR1A"    "FCGR2A"    "FCGR3A"    "FGR"      
##  [7] "FYN"       "HCK"       "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"    
## [13] "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11" 
## [19] "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53" 
## [25] "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12" 
## [31] "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28" 
## [37] "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20" 
## [43] "IGKV3D-20" "IGKV4-1"   "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"    
## [49] "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11" 
## [55] "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12" 
## [61] "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69" 
## [67] "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "LYN"      
## [73] "SRC"       "SYK"       "YES1"     
## 
## [[1]]$`DOWN genesets.FCGR3A-mediated IL10 synthesis`
##  [1] "ADCY2"     "ADCY3"     "ADCY4"     "ADCY5"     "ADCY6"     "ADCY7"    
##  [7] "ADCY9"     "AHCYL1"    "CALM1"     "CD247"     "CD3G"      "CREB1"    
## [13] "FCGR1A"    "FCGR2A"    "FCGR3A"    "FGR"       "FYN"       "HCK"      
## [19] "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46" 
## [25] "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23" 
## [31] "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34" 
## [37] "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17" 
## [43] "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30" 
## [49] "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"  
## [55] "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLV1-36"  "IGLV1-40" 
## [61] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-18" 
## [67] "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21" 
## [73] "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57" 
## [79] "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "IL10"      "ITPR1"     "ITPR2"    
## [85] "ITPR3"     "LYN"       "PLCG1"     "PLCG2"     "PRKACA"    "PRKACB"   
## [91] "PRKAR1A"   "PRKAR1B"   "PRKAR2A"   "PRKAR2B"   "PRKX"      "SRC"      
## [97] "SYK"       "YES1"     
## 
## [[1]]$`DOWN genesets.G2/M DNA replication checkpoint`
## [1] "CCNB1"  "CCNB2"  "CDK1"   "PKMYT1" "WEE1"  
## 
## [[1]]$`DOWN genesets.Initial triggering of complement`
##  [1] "C1QA"      "C1QB"      "C1QC"      "C1R"       "C1S"       "C2"       
##  [7] "C3"        "C4A"       "C4B"       "CFB"       "CFD"       "CFP"      
## [13] "FCN1"      "GZMM"      "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"    
## [19] "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11" 
## [25] "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53" 
## [31] "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12" 
## [37] "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28" 
## [43] "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20" 
## [49] "IGKV3D-20" "IGKV4-1"   "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"    
## [55] "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11" 
## [61] "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12" 
## [67] "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69" 
## [73] "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "MASP2"    
## 
## [[1]]$`DOWN genesets.Interleukin-21 signaling`
## [1] "IL21R"  "IL2RG"  "JAK1"   "JAK3"   "STAT1"  "STAT3"  "STAT4"  "STAT5A"
## [9] "STAT5B"
## 
## [[1]]$`DOWN genesets.Maturation of protein 3a_9683673`
## [1] "GALNT1"     "ST3GAL1"    "ST3GAL2"    "ST3GAL3"    "ST3GAL4"   
## [6] "ST6GAL1"    "ST6GALNAC2" "ST6GALNAC3" "ST6GALNAC4"
## 
## [[1]]$`DOWN genesets.Maturation of protein 3a_9694719`
## [1] "GALNT1"     "ST3GAL1"    "ST3GAL2"    "ST3GAL3"    "ST3GAL4"   
## [6] "ST6GAL1"    "ST6GALNAC2" "ST6GALNAC3" "ST6GALNAC4"
## 
## [[1]]$`DOWN genesets.Phosphorylation of Emi1`
## [1] "CCNB1" "CDC20" "CDK1"  "FBXO5" "FZR1"  "PLK1" 
## 
## [[1]]$`DOWN genesets.Role of LAT2/NTAL/LAB on calcium mobilization`
##  [1] "FCER1A"    "FCER1G"    "FYN"       "GAB2"      "GRB2"      "IGHE"     
##  [7] "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11" 
## [13] "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53" 
## [19] "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12" 
## [25] "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28" 
## [31] "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20" 
## [37] "IGKV3D-20" "IGKV4-1"   "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"    
## [43] "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11" 
## [49] "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12" 
## [55] "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69" 
## [61] "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "LAT2"     
## [67] "LYN"       "MS4A2"     "PDPK1"     "PIK3CA"    "PIK3CB"    "PIK3R1"   
## [73] "PIK3R2"    "SHC1"      "SOS1"      "SYK"      
## 
## [[1]]$`DOWN genesets.Role of phospholipids in phagocytosis`
##  [1] "AHCYL1"    "CD247"     "CD3G"      "FCGR1A"    "FCGR2A"    "FCGR3A"   
##  [7] "IGHG1"     "IGHG2"     "IGHG3"     "IGHG4"     "IGHV1-2"   "IGHV1-46" 
## [13] "IGHV1-69"  "IGHV2-5"   "IGHV2-70"  "IGHV3-11"  "IGHV3-13"  "IGHV3-23" 
## [19] "IGHV3-30"  "IGHV3-33"  "IGHV3-48"  "IGHV3-53"  "IGHV3-7"   "IGHV4-34" 
## [25] "IGHV4-39"  "IGHV4-59"  "IGKC"      "IGKV1-12"  "IGKV1-16"  "IGKV1-17" 
## [31] "IGKV1-33"  "IGKV1-5"   "IGKV1D-39" "IGKV2-28"  "IGKV2-29"  "IGKV2-30" 
## [37] "IGKV2D-28" "IGKV3-11"  "IGKV3-15"  "IGKV3-20"  "IGKV3D-20" "IGKV4-1"  
## [43] "IGKV5-2"   "IGLC1"     "IGLC2"     "IGLC3"     "IGLV1-36"  "IGLV1-40" 
## [49] "IGLV1-44"  "IGLV1-47"  "IGLV1-51"  "IGLV2-11"  "IGLV2-14"  "IGLV2-18" 
## [55] "IGLV2-23"  "IGLV2-8"   "IGLV3-1"   "IGLV3-12"  "IGLV3-19"  "IGLV3-21" 
## [61] "IGLV3-25"  "IGLV3-27"  "IGLV4-60"  "IGLV4-69"  "IGLV5-45"  "IGLV6-57" 
## [67] "IGLV7-43"  "IGLV7-46"  "IGLV8-61"  "ITPR1"     "ITPR2"     "ITPR3"    
## [73] "PIK3CA"    "PIK3CB"    "PIK3R1"    "PIK3R2"    "PLA2G6"    "PLCG1"    
## [79] "PLCG2"     "PLD1"      "PLD2"      "PLD4"      "PLPP5"     "PRKCD"    
## [85] "PRKCE"     "SYK"      
## 
## [[1]]$`DOWN genesets.Scavenging of heme from plasma`
##  [1] "APOL1"     "HBA1"      "HBB"       "HP"        "HPX"       "IGHA1"    
##  [7] "IGHA2"     "IGHV1-2"   "IGHV1-46"  "IGHV1-69"  "IGHV2-5"   "IGHV2-70" 
## [13] "IGHV3-11"  "IGHV3-13"  "IGHV3-23"  "IGHV3-30"  "IGHV3-33"  "IGHV3-48" 
## [19] "IGHV3-53"  "IGHV3-7"   "IGHV4-34"  "IGHV4-39"  "IGHV4-59"  "IGKC"     
## [25] "IGKV1-12"  "IGKV1-16"  "IGKV1-17"  "IGKV1-33"  "IGKV1-5"   "IGKV1D-39"
## [31] "IGKV2-28"  "IGKV2-29"  "IGKV2-30"  "IGKV2D-28" "IGKV3-11"  "IGKV3-15" 
## [37] "IGKV3-20"  "IGKV3D-20" "IGKV4-1"   "IGKV5-2"   "IGLC1"     "IGLC2"    
## [43] "IGLC3"     "IGLV1-36"  "IGLV1-40"  "IGLV1-44"  "IGLV1-47"  "IGLV1-51" 
## [49] "IGLV2-11"  "IGLV2-14"  "IGLV2-18"  "IGLV2-23"  "IGLV2-8"   "IGLV3-1"  
## [55] "IGLV3-12"  "IGLV3-19"  "IGLV3-21"  "IGLV3-25"  "IGLV3-27"  "IGLV4-60" 
## [61] "IGLV4-69"  "IGLV5-45"  "IGLV6-57"  "IGLV7-43"  "IGLV7-46"  "IGLV8-61" 
## [67] "JCHAIN"    "LRP1"     
## 
## [[1]]$`DOWN genesets.Type I hemidesmosome assembly`
## [1] "CD151"   "COL17A1" "DST"     "ITGA6"   "ITGB4"   "KRT5"    "LAMB3"  
## [8] "PLEC"   
## 
## [[1]]$`DOWN genesets.Unwinding of DNA`
##  [1] "CDC45" "GINS1" "GINS2" "GINS3" "GINS4" "MCM2"  "MCM3"  "MCM4"  "MCM5" 
## [10] "MCM6"  "MCM7"  "MCM8"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report