date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 1.4505646
A1BG -1.1728726
A1BG-AS1 -0.6702606
A1CF 0.8579257
A2M 1.0361725
A2M-AS1 1.0211960

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
RUNX1 regulates expression of components of tight junctions 5 1.24e-03 0.834 1.12e-02
APOBEC3G mediated resistance to HIV-1 infection 5 2.84e-03 -0.771 2.24e-02
CD163 mediating an anti-inflammatory response 9 7.64e-05 0.761 1.03e-03
Formation of the ureteric bud 5 3.30e-03 0.759 2.53e-02
RUNX1 regulates transcription of genes involved in BCR signaling 6 1.47e-03 0.750 1.28e-02
Phenylalanine metabolism 5 4.32e-03 -0.737 3.01e-02
Biosynthesis of Lipoxins (LX) 6 2.53e-03 0.712 2.02e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 7.97e-03 0.685 4.86e-02
POLB-Dependent Long Patch Base Excision Repair 8 9.28e-04 -0.676 8.64e-03
Peptide chain elongation 88 8.35e-27 -0.660 2.30e-24
Eukaryotic Translation Elongation 93 1.20e-27 -0.653 3.88e-25
Formation of a pool of free 40S subunits 100 7.61e-29 -0.644 4.90e-26
SARS-CoV-1 modulates host translation machinery 36 2.66e-11 -0.642 9.18e-10
Eukaryotic Translation Termination 92 1.99e-26 -0.641 4.27e-24
Viral mRNA Translation 88 2.42e-25 -0.641 3.59e-23
Selenocysteine synthesis 92 7.03e-26 -0.634 1.13e-23
RHOT1 GTPase cycle 5 1.48e-02 0.630 8.15e-02
TNFR1-mediated ceramide production 6 9.13e-03 -0.615 5.48e-02
G2 Phase 5 2.05e-02 0.598 1.00e-01
Propionyl-CoA catabolism 5 2.15e-02 -0.594 1.04e-01
Formation of xylulose-5-phosphate 5 2.15e-02 -0.594 1.04e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 4.55e-23 -0.590 5.17e-21
NFE2L2 regulates pentose phosphate pathway genes 8 4.06e-03 0.587 2.88e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.39e-26 -0.586 3.37e-24
Translocation of ZAP-70 to Immunological synapse 24 6.92e-07 -0.585 1.63e-05
G2/M DNA replication checkpoint 5 2.35e-02 0.585 1.10e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 2.96e-26 -0.584 5.72e-24
Cap-dependent Translation Initiation 118 5.86e-28 -0.583 2.26e-25
Eukaryotic Translation Initiation 118 5.86e-28 -0.583 2.26e-25
CD22 mediated BCR regulation 58 2.30e-14 0.579 1.14e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 3.78e-23 -0.573 4.57e-21
Formation of the ternary complex, and subsequently, the 43S complex 51 1.47e-12 -0.573 6.18e-11
Scavenging of heme from plasma 70 1.36e-16 0.571 9.38e-15
Mitochondrial Uncoupling 6 1.62e-02 -0.567 8.55e-02
MET activates PI3K/AKT signaling 5 2.82e-02 0.567 1.26e-01
SARS-CoV-2 modulates host translation machinery 49 7.32e-12 -0.565 2.72e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 9.92e-03 0.563 5.90e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.47e-03 0.563 2.61e-02
Folding of actin by CCT/TriC 10 2.15e-03 -0.560 1.75e-02
Defective binding of VWF variant to GPIb:IX:V 7 1.22e-02 0.547 7.01e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.22e-02 0.547 7.01e-02
SRP-dependent cotranslational protein targeting to membrane 111 3.33e-23 -0.545 4.29e-21
Tandem pore domain potassium channels 5 3.55e-02 -0.543 1.48e-01
Sperm Motility And Taxes 6 2.21e-02 -0.540 1.06e-01
Classical antibody-mediated complement activation 69 1.05e-14 0.538 5.79e-13
Proton-coupled monocarboxylate transport 6 2.26e-02 0.537 1.08e-01
Aryl hydrocarbon receptor signalling 6 2.32e-02 -0.535 1.10e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 5.47e-05 0.535 7.71e-04
Inactivation of CDC42 and RAC1 7 1.43e-02 0.535 7.97e-02
Protein repair 6 2.38e-02 0.533 1.12e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
RUNX1 regulates expression of components of tight junctions 5 1.24e-03 0.834000 1.12e-02
APOBEC3G mediated resistance to HIV-1 infection 5 2.84e-03 -0.771000 2.24e-02
CD163 mediating an anti-inflammatory response 9 7.64e-05 0.761000 1.03e-03
Formation of the ureteric bud 5 3.30e-03 0.759000 2.53e-02
RUNX1 regulates transcription of genes involved in BCR signaling 6 1.47e-03 0.750000 1.28e-02
Phenylalanine metabolism 5 4.32e-03 -0.737000 3.01e-02
Biosynthesis of Lipoxins (LX) 6 2.53e-03 0.712000 2.02e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 7.97e-03 0.685000 4.86e-02
POLB-Dependent Long Patch Base Excision Repair 8 9.28e-04 -0.676000 8.64e-03
Peptide chain elongation 88 8.35e-27 -0.660000 2.30e-24
Eukaryotic Translation Elongation 93 1.20e-27 -0.653000 3.88e-25
Formation of a pool of free 40S subunits 100 7.61e-29 -0.644000 4.90e-26
SARS-CoV-1 modulates host translation machinery 36 2.66e-11 -0.642000 9.18e-10
Eukaryotic Translation Termination 92 1.99e-26 -0.641000 4.27e-24
Viral mRNA Translation 88 2.42e-25 -0.641000 3.59e-23
Selenocysteine synthesis 92 7.03e-26 -0.634000 1.13e-23
RHOT1 GTPase cycle 5 1.48e-02 0.630000 8.15e-02
TNFR1-mediated ceramide production 6 9.13e-03 -0.615000 5.48e-02
G2 Phase 5 2.05e-02 0.598000 1.00e-01
Propionyl-CoA catabolism 5 2.15e-02 -0.594000 1.04e-01
Formation of xylulose-5-phosphate 5 2.15e-02 -0.594000 1.04e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 4.55e-23 -0.590000 5.17e-21
NFE2L2 regulates pentose phosphate pathway genes 8 4.06e-03 0.587000 2.88e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.39e-26 -0.586000 3.37e-24
Translocation of ZAP-70 to Immunological synapse 24 6.92e-07 -0.585000 1.63e-05
G2/M DNA replication checkpoint 5 2.35e-02 0.585000 1.10e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 2.96e-26 -0.584000 5.72e-24
Cap-dependent Translation Initiation 118 5.86e-28 -0.583000 2.26e-25
Eukaryotic Translation Initiation 118 5.86e-28 -0.583000 2.26e-25
CD22 mediated BCR regulation 58 2.30e-14 0.579000 1.14e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 3.78e-23 -0.573000 4.57e-21
Formation of the ternary complex, and subsequently, the 43S complex 51 1.47e-12 -0.573000 6.18e-11
Scavenging of heme from plasma 70 1.36e-16 0.571000 9.38e-15
Mitochondrial Uncoupling 6 1.62e-02 -0.567000 8.55e-02
MET activates PI3K/AKT signaling 5 2.82e-02 0.567000 1.26e-01
SARS-CoV-2 modulates host translation machinery 49 7.32e-12 -0.565000 2.72e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 9.92e-03 0.563000 5.90e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.47e-03 0.563000 2.61e-02
Folding of actin by CCT/TriC 10 2.15e-03 -0.560000 1.75e-02
Defective binding of VWF variant to GPIb:IX:V 7 1.22e-02 0.547000 7.01e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.22e-02 0.547000 7.01e-02
SRP-dependent cotranslational protein targeting to membrane 111 3.33e-23 -0.545000 4.29e-21
Tandem pore domain potassium channels 5 3.55e-02 -0.543000 1.48e-01
Sperm Motility And Taxes 6 2.21e-02 -0.540000 1.06e-01
Classical antibody-mediated complement activation 69 1.05e-14 0.538000 5.79e-13
Proton-coupled monocarboxylate transport 6 2.26e-02 0.537000 1.08e-01
Aryl hydrocarbon receptor signalling 6 2.32e-02 -0.535000 1.10e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 5.47e-05 0.535000 7.71e-04
Inactivation of CDC42 and RAC1 7 1.43e-02 0.535000 7.97e-02
Protein repair 6 2.38e-02 0.533000 1.12e-01
Selenoamino acid metabolism 115 1.01e-22 -0.529000 1.08e-20
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.79e-22 -0.528000 1.73e-20
Nonsense-Mediated Decay (NMD) 114 1.79e-22 -0.528000 1.73e-20
FBXW7 Mutants and NOTCH1 in Cancer 5 4.45e-02 -0.519000 1.73e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 4.45e-02 -0.519000 1.73e-01
Regulation of FOXO transcriptional activity by acetylation 10 4.58e-03 0.518000 3.17e-02
Replacement of protamines by nucleosomes in the male pronucleus 13 1.26e-03 0.517000 1.12e-02
Signal attenuation 9 7.54e-03 0.514000 4.67e-02
Creation of C4 and C2 activators 71 1.02e-13 0.510000 4.48e-12
MET activates RAP1 and RAC1 10 5.31e-03 0.509000 3.60e-02
Role of LAT2/NTAL/LAB on calcium mobilization 77 1.65e-14 0.506000 8.61e-13
PD-1 signaling 28 3.83e-06 -0.504000 7.41e-05
ARMS-mediated activation 6 3.27e-02 0.504000 1.39e-01
PI3K/AKT activation 8 1.37e-02 0.503000 7.70e-02
Miro GTPase Cycle 8 1.38e-02 0.503000 7.75e-02
Prostanoid ligand receptors 8 1.39e-02 0.502000 7.81e-02
Regulation of expression of SLITs and ROBOs 149 4.27e-26 -0.501000 7.51e-24
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 3.37e-02 0.501000 1.42e-01
Common Pathway of Fibrin Clot Formation 13 1.81e-03 0.500000 1.53e-02
Translation initiation complex formation 58 5.79e-11 -0.497000 1.90e-09
Influenza Viral RNA Transcription and Replication 135 2.01e-23 -0.497000 2.78e-21
Ribosomal scanning and start codon recognition 58 6.03e-11 -0.496000 1.94e-09
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.60e-11 -0.495000 1.53e-09
Prolonged ERK activation events 13 1.99e-03 0.495000 1.64e-02
FCGR activation 76 8.85e-14 0.494000 4.17e-12
Anchoring fibril formation 10 7.13e-03 0.491000 4.48e-02
Estrogen biosynthesis 5 5.84e-02 0.489000 2.04e-01
Vpu mediated degradation of CD4 39 1.82e-07 -0.483000 4.45e-06
Acetylcholine Neurotransmitter Release Cycle 11 5.72e-03 -0.481000 3.82e-02
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 2.84e-02 -0.478000 1.26e-01
Phosphorylation of CD3 and TCR zeta chains 27 1.81e-05 -0.477000 2.90e-04
Coenzyme A biosynthesis 7 2.93e-02 -0.476000 1.28e-01
Mitochondrial translation initiation 90 6.07e-15 -0.476000 3.45e-13
Chromatin modifications during the maternal to zygotic transition (MZT) 23 8.50e-05 0.473000 1.11e-03
Frs2-mediated activation 11 6.66e-03 0.472000 4.23e-02
Regulation of Complement cascade 96 1.28e-15 0.472000 7.95e-14
Translation 293 1.09e-43 -0.470000 2.10e-40
Mitochondrial translation elongation 90 1.37e-14 -0.469000 7.35e-13
Mitochondrial translation 96 2.72e-15 -0.466000 1.59e-13
Mitochondrial translation termination 90 2.30e-14 -0.465000 1.14e-12
CYP2E1 reactions 6 4.87e-02 -0.465000 1.81e-01
TICAM1-dependent activation of IRF3/IRF7 13 3.87e-03 -0.463000 2.78e-02
Autodegradation of the E3 ubiquitin ligase COP1 38 8.21e-07 -0.462000 1.87e-05
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 7.04e-05 -0.459000 9.64e-04
NFE2L2 regulating tumorigenic genes 11 8.42e-03 0.459000 5.08e-02
2-LTR circle formation 7 3.58e-02 -0.458000 1.48e-01
Proteasome assembly 50 2.33e-08 -0.456000 6.18e-07
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.25e-02 0.456000 7.10e-02
Recycling of eIF2:GDP 8 2.56e-02 -0.456000 1.17e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 3.78e-02 -0.453000 1.56e-01
Cytosolic tRNA aminoacylation 24 1.28e-04 -0.452000 1.58e-03
NIK–>noncanonical NF-kB signaling 46 1.18e-07 -0.451000 2.99e-06
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.94e-06 -0.451000 7.46e-05
BBSome-mediated cargo-targeting to cilium 22 2.55e-04 -0.450000 2.86e-03
Influenza Infection 154 5.73e-22 -0.449000 5.27e-20
MET receptor recycling 9 2.00e-02 0.448000 9.88e-02
HSF1 activation 26 8.04e-05 -0.447000 1.06e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 5.49e-04 0.446000 5.47e-03
RHOT2 GTPase cycle 7 4.10e-02 0.446000 1.64e-01
OAS antiviral response 8 2.91e-02 -0.446000 1.27e-01
PCNA-Dependent Long Patch Base Excision Repair 21 4.21e-04 -0.444000 4.42e-03
Initial triggering of complement 79 9.01e-12 0.444000 3.28e-10
Inhibition of Signaling by Overexpressed EGFR 6 6.00e-02 0.443000 2.06e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 6.00e-02 0.443000 2.06e-01
Butyrophilin (BTN) family interactions 9 2.13e-02 -0.443000 1.04e-01
Defective factor IX causes hemophilia B 6 6.02e-02 0.443000 2.06e-01
Ubiquitin-dependent degradation of Cyclin D 39 1.73e-06 -0.443000 3.66e-05
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 8.07e-03 0.442000 4.90e-02
Dermatan sulfate biosynthesis 6 6.17e-02 0.440000 2.08e-01
Defects of platelet adhesion to exposed collagen 8 3.12e-02 0.440000 1.35e-01
Interleukin-21 signaling 9 2.24e-02 -0.440000 1.07e-01
Regulation of CDH19 Expression and Function 6 6.24e-02 -0.439000 2.09e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 1.40e-07 -0.439000 3.47e-06
Digestion and absorption 7 4.49e-02 0.438000 1.73e-01
MECP2 regulates transcription of neuronal ligands 5 9.03e-02 -0.437000 2.69e-01
Scavenging by Class F Receptors 5 9.19e-02 -0.435000 2.72e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 1.22e-06 -0.433000 2.67e-05
tRNA processing in the mitochondrion 24 2.59e-04 0.431000 2.89e-03
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.57e-02 -0.430000 2.79e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.51e-06 -0.429000 3.24e-05
Digestion 5 9.70e-02 0.429000 2.81e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 2.13e-06 -0.428000 4.32e-05
Complement cascade 100 1.46e-13 0.427000 6.25e-12
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 6.88e-06 -0.427000 1.21e-04
Purine salvage 12 1.07e-02 -0.426000 6.30e-02
Keratan sulfate degradation 9 2.72e-02 0.425000 1.22e-01
Generation of second messenger molecules 38 6.34e-06 -0.423000 1.13e-04
Vif-mediated degradation of APOBEC3G 41 2.76e-06 -0.423000 5.49e-05
Erythrocytes take up carbon dioxide and release oxygen 11 1.54e-02 0.422000 8.27e-02
O2/CO2 exchange in erythrocytes 11 1.54e-02 0.422000 8.27e-02
Integration of provirus 9 2.90e-02 -0.420000 1.27e-01
Interferon alpha/beta signaling 64 6.52e-09 -0.419000 1.77e-07
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 2.72e-06 -0.418000 5.48e-05
Chondroitin sulfate biosynthesis 12 1.25e-02 0.417000 7.10e-02
ChREBP activates metabolic gene expression 7 5.68e-02 0.416000 2.00e-01
Role of phospholipids in phagocytosis 88 1.67e-11 0.415000 5.98e-10
Negative regulation of NOTCH4 signaling 44 2.03e-06 -0.414000 4.17e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 7.92e-06 -0.413000 1.35e-04
p53-Independent DNA Damage Response 39 7.92e-06 -0.413000 1.35e-04
p53-Independent G1/S DNA damage checkpoint 39 7.92e-06 -0.413000 1.35e-04
Leading Strand Synthesis 14 7.48e-03 -0.413000 4.65e-02
Polymerase switching 14 7.48e-03 -0.413000 4.65e-02
PTK6 Regulates Cell Cycle 6 7.99e-02 -0.413000 2.51e-01
Early Phase of HIV Life Cycle 14 7.68e-03 -0.411000 4.72e-02
Glucuronidation 9 3.30e-02 0.410000 1.40e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 1.18e-10 0.409000 3.69e-09
RNA Polymerase I Promoter Opening 17 3.54e-03 0.409000 2.62e-02
Neurotransmitter clearance 6 8.32e-02 0.408000 2.57e-01
Diseases of hemostasis 15 6.26e-03 0.408000 4.05e-02
Physiological factors 9 3.42e-02 0.408000 1.44e-01
Nucleotide biosynthesis 12 1.49e-02 -0.406000 8.16e-02
Formation of the active cofactor, UDP-glucuronate 5 1.16e-01 0.406000 3.18e-01
FCGR3A-mediated IL10 synthesis 99 3.45e-12 0.404000 1.31e-10
Synthesis of PIPs at the late endosome membrane 11 2.05e-02 0.404000 1.00e-01
Organic cation transport 8 4.91e-02 0.402000 1.81e-01
Organic cation/anion/zwitterion transport 8 4.91e-02 0.402000 1.81e-01
Creatine metabolism 6 8.88e-02 -0.401000 2.66e-01
Methionine salvage pathway 6 8.88e-02 -0.401000 2.66e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.17e-20 -0.401000 1.67e-18
Stabilization of p53 43 5.48e-06 -0.401000 9.98e-05
Binding and Uptake of Ligands by Scavenger Receptors 94 1.97e-11 0.400000 6.94e-10
Mitochondrial RNA degradation 25 5.57e-04 0.399000 5.52e-03
Erythrocytes take up oxygen and release carbon dioxide 7 6.82e-02 0.398000 2.25e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.24e-01 -0.398000 3.32e-01
Neurofascin interactions 5 1.24e-01 0.397000 3.32e-01
Vitamin B2 (riboflavin) metabolism 6 9.29e-02 -0.396000 2.73e-01
rRNA processing in the nucleus and cytosol 189 8.04e-21 -0.394000 7.06e-19
FCERI mediated Ca+2 mobilization 92 6.44e-11 0.394000 2.04e-09
Processing of SMDT1 15 8.57e-03 -0.392000 5.16e-02
Antimicrobial peptides 34 7.69e-05 0.392000 1.03e-03
Degradation of AXIN 42 1.12e-05 -0.392000 1.88e-04
Regulation of Apoptosis 40 1.82e-05 -0.392000 2.90e-04
Release of apoptotic factors from the mitochondria 6 9.68e-02 -0.391000 2.80e-01
Attenuation phase 23 1.16e-03 -0.391000 1.06e-02
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 4.09e-03 -0.391000 2.89e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.48e-02 0.391000 8.15e-02
GABA synthesis, release, reuptake and degradation 12 1.93e-02 -0.390000 9.66e-02
Resolution of Abasic Sites (AP sites) 38 3.37e-05 -0.389000 5.08e-04
LTC4-CYSLTR mediated IL4 production 5 1.32e-01 -0.389000 3.42e-01
Degradation of DVL 43 1.08e-05 -0.388000 1.83e-04
CDH11 homotypic and heterotypic interactions 6 1.01e-01 -0.387000 2.89e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 8.61e-04 -0.385000 8.15e-03
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 2.74e-02 -0.384000 1.23e-01
Assembly of active LPL and LIPC lipase complexes 10 3.60e-02 0.383000 1.49e-01
RSK activation 7 7.98e-02 0.382000 2.51e-01
Cellular response to starvation 148 2.21e-15 -0.377000 1.33e-13
DNA methylation 18 5.68e-03 0.377000 3.81e-02
Uptake of dietary cobalamins into enterocytes 6 1.10e-01 -0.376000 3.09e-01
FCERI mediated MAPK activation 93 3.49e-10 0.376000 1.04e-08
Estrogen-stimulated signaling through PRKCZ 6 1.11e-01 0.376000 3.09e-01
Synthesis of 5-eicosatetraenoic acids 7 8.51e-02 0.376000 2.61e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 1.77e-06 -0.376000 3.73e-05
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 1.50e-02 -0.375000 8.21e-02
mRNA Splicing - Major Pathway 203 2.88e-20 -0.375000 2.14e-18
Trafficking and processing of endosomal TLR 13 1.92e-02 -0.375000 9.65e-02
Anti-inflammatory response favouring Leishmania parasite infection 132 9.86e-14 0.375000 4.43e-12
Leishmania parasite growth and survival 132 9.86e-14 0.375000 4.43e-12
tRNA Aminoacylation 42 2.66e-05 -0.375000 4.11e-04
Reelin signalling pathway 5 1.47e-01 0.374000 3.64e-01
Degradation of GLI2 by the proteasome 45 1.44e-05 -0.374000 2.38e-04
NFE2L2 regulating MDR associated enzymes 8 6.73e-02 0.373000 2.23e-01
mRNA Splicing 211 8.92e-21 -0.373000 7.49e-19
Signaling by ROBO receptors 189 9.82e-19 -0.372000 7.03e-17
FCGR3A-mediated phagocytosis 121 1.64e-12 0.372000 6.45e-11
Leishmania phagocytosis 121 1.64e-12 0.372000 6.45e-11
Parasite infection 121 1.64e-12 0.372000 6.45e-11
PI-3K cascade:FGFR1 13 2.04e-02 0.371000 1.00e-01
Malate-aspartate shuttle 8 7.05e-02 -0.369000 2.30e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 1.53e-01 -0.369000 3.74e-01
mRNA Splicing - Minor Pathway 50 6.41e-06 -0.369000 1.14e-04
Hh mutants are degraded by ERAD 42 3.54e-05 -0.369000 5.30e-04
Formation of Fibrin Clot (Clotting Cascade) 26 1.17e-03 0.368000 1.07e-02
SLBP independent Processing of Histone Pre-mRNAs 10 4.43e-02 -0.367000 1.73e-01
GLI3 is processed to GLI3R by the proteasome 46 1.64e-05 -0.367000 2.68e-04
Carnitine shuttle 12 2.84e-02 -0.365000 1.26e-01
Somitogenesis 41 5.42e-05 -0.364000 7.70e-04
Signaling by NODAL 15 1.48e-02 0.363000 8.16e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 3.72e-02 -0.363000 1.53e-01
Protein lipoylation 10 4.70e-02 -0.363000 1.78e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 1.60e-01 -0.363000 3.82e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 1.61e-01 -0.362000 3.82e-01
Translesion synthesis by REV1 16 1.24e-02 -0.361000 7.06e-02
Interleukin-18 signaling 6 1.26e-01 0.360000 3.36e-01
Suppression of apoptosis 7 9.92e-02 0.360000 2.86e-01
APC/C:Cdc20 mediated degradation of Securin 55 3.91e-06 -0.360000 7.46e-05
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 2.00e-02 -0.359000 9.87e-02
Regulation of ornithine decarboxylase (ODC) 38 1.37e-04 -0.357000 1.68e-03
Platelet Adhesion to exposed collagen 16 1.35e-02 0.357000 7.61e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 1.30e-01 -0.357000 3.42e-01
Uptake and function of diphtheria toxin 6 1.30e-01 -0.356000 3.42e-01
Lagging Strand Synthesis 20 5.84e-03 -0.356000 3.89e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.11e-02 -0.356000 1.64e-01
Polymerase switching on the C-strand of the telomere 26 1.73e-03 -0.355000 1.47e-02
Cytosolic iron-sulfur cluster assembly 13 2.71e-02 -0.354000 1.22e-01
Apoptotic cleavage of cell adhesion proteins 8 8.30e-02 0.354000 2.57e-01
Synthesis of diphthamide-EEF2 8 8.35e-02 -0.353000 2.58e-01
Hh mutants abrogate ligand secretion 43 6.37e-05 -0.352000 8.85e-04
RUNX3 regulates p14-ARF 10 5.38e-02 0.352000 1.92e-01
Response to metal ions 6 1.35e-01 0.352000 3.47e-01
AMPK inhibits chREBP transcriptional activation activity 6 1.36e-01 0.352000 3.48e-01
SCF(Skp2)-mediated degradation of p27/p21 50 1.72e-05 -0.351000 2.80e-04
GAB1 signalosome 15 1.87e-02 0.351000 9.45e-02
Processive synthesis on the lagging strand 15 1.94e-02 -0.349000 9.66e-02
Degradation of GLI1 by the proteasome 46 4.33e-05 -0.348000 6.38e-04
Glycerophospholipid catabolism 6 1.40e-01 -0.348000 3.54e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 1.41e-01 0.347000 3.56e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 1.14e-01 0.345000 3.16e-01
Other semaphorin interactions 16 1.69e-02 0.345000 8.81e-02
Complex I biogenesis 66 1.30e-06 -0.344000 2.82e-05
Crosslinking of collagen fibrils 15 2.17e-02 0.342000 1.04e-01
Amyloid fiber formation 52 1.94e-05 0.342000 3.04e-04
Role of ABL in ROBO-SLIT signaling 6 1.47e-01 0.342000 3.64e-01
Transcriptional regulation of granulopoiesis 44 8.90e-05 0.341000 1.15e-03
Mitochondrial unfolded protein response (UPRmt) 17 1.49e-02 -0.341000 8.16e-02
PI-3K cascade:FGFR3 10 6.19e-02 0.341000 2.08e-01
Transport of RCbl within the body 8 9.52e-02 0.341000 2.78e-01
HSF1-dependent transactivation 30 1.26e-03 -0.340000 1.12e-02
Purine ribonucleoside monophosphate biosynthesis 9 7.79e-02 -0.339000 2.46e-01
RHO GTPases activate PKNs 46 7.31e-05 0.338000 9.94e-04
RHOJ GTPase cycle 50 3.67e-05 0.337000 5.45e-04
Phenylalanine and tyrosine metabolism 9 8.07e-02 -0.336000 2.53e-01
Synthesis, secretion, and deacylation of Ghrelin 11 5.39e-02 -0.336000 1.92e-01
Regulation of actin dynamics for phagocytic cup formation 123 1.37e-10 0.335000 4.21e-09
N-glycan antennae elongation in the medial/trans-Golgi 21 7.93e-03 0.335000 4.86e-02
STAT3 nuclear events downstream of ALK signaling 11 5.51e-02 -0.334000 1.95e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.26e-01 0.334000 3.35e-01
Mitochondrial protein import 63 4.56e-06 -0.334000 8.47e-05
Fibronectin matrix formation 6 1.57e-01 0.333000 3.79e-01
N-Glycan antennae elongation 13 3.81e-02 0.332000 1.56e-01
Acetylcholine binding and downstream events 5 1.99e-01 0.332000 4.28e-01
Postsynaptic nicotinic acetylcholine receptors 5 1.99e-01 0.332000 4.28e-01
SARS-CoV-1-host interactions 95 2.41e-08 -0.331000 6.29e-07
Assembly of the ORC complex at the origin of replication 23 6.09e-03 0.330000 3.97e-02
GP1b-IX-V activation signalling 12 4.76e-02 0.330000 1.79e-01
Cristae formation 33 1.04e-03 -0.330000 9.60e-03
Regulated proteolysis of p75NTR 11 5.98e-02 0.328000 2.06e-01
Caspase activation via Death Receptors in the presence of ligand 16 2.34e-02 -0.327000 1.10e-01
Specification of primordial germ cells 6 1.65e-01 0.327000 3.89e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 4.52e-05 -0.327000 6.61e-04
Mitochondrial iron-sulfur cluster biogenesis 13 4.14e-02 -0.327000 1.65e-01
p53-Dependent G1 DNA Damage Response 52 4.61e-05 -0.327000 6.64e-04
p53-Dependent G1/S DNA damage checkpoint 52 4.61e-05 -0.327000 6.64e-04
Regulation of RUNX3 expression and activity 45 1.56e-04 -0.326000 1.87e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 3.49e-02 -0.326000 1.46e-01
MAPK3 (ERK1) activation 10 7.51e-02 0.325000 2.41e-01
Na+/Cl- dependent neurotransmitter transporters 8 1.12e-01 0.324000 3.13e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.40e-20 -0.323000 1.13e-18
rRNA processing 213 4.30e-16 -0.323000 2.77e-14
Complex III assembly 23 7.57e-03 -0.322000 4.67e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 2.14e-01 -0.321000 4.43e-01
Mitochondrial tRNA aminoacylation 21 1.09e-02 -0.321000 6.41e-02
Translesion synthesis by POLK 17 2.26e-02 -0.320000 1.08e-01
Defective CFTR causes cystic fibrosis 47 1.53e-04 -0.319000 1.86e-03
Regulation of innate immune responses to cytosolic DNA 14 3.88e-02 -0.319000 1.59e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 2.18e-01 0.318000 4.49e-01
Non-integrin membrane-ECM interactions 51 8.57e-05 0.318000 1.11e-03
Packaging Of Telomere Ends 18 1.97e-02 0.318000 9.74e-02
p130Cas linkage to MAPK signaling for integrins 11 6.86e-02 0.317000 2.26e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.22e-01 -0.316000 3.29e-01
EGFR downregulation 27 4.74e-03 0.314000 3.27e-02
Activation of Ca-permeable Kainate Receptor 9 1.03e-01 0.314000 2.93e-01
Ionotropic activity of kainate receptors 9 1.03e-01 0.314000 2.93e-01
CASP8 activity is inhibited 11 7.15e-02 -0.314000 2.32e-01
Dimerization of procaspase-8 11 7.15e-02 -0.314000 2.32e-01
Regulation by c-FLIP 11 7.15e-02 -0.314000 2.32e-01
Abacavir ADME 5 2.25e-01 0.313000 4.59e-01
CD28 dependent Vav1 pathway 12 6.02e-02 -0.313000 2.06e-01
CDK-mediated phosphorylation and removal of Cdc6 60 2.74e-05 -0.313000 4.20e-04
Dual Incision in GG-NER 41 5.49e-04 -0.312000 5.47e-03
Translesion synthesis by POLI 17 2.60e-02 -0.312000 1.19e-01
SIRT1 negatively regulates rRNA expression 22 1.20e-02 0.310000 6.92e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.83e-02 0.309000 1.57e-01
Organic anion transporters 7 1.58e-01 -0.308000 3.79e-01
SARS-CoV-1 activates/modulates innate immune responses 40 7.41e-04 -0.308000 7.09e-03
Mitochondrial Fatty Acid Beta-Oxidation 36 1.39e-03 -0.308000 1.22e-02
Metabolism of polyamines 46 3.10e-04 -0.307000 3.43e-03
Regulation of RUNX2 expression and activity 54 9.79e-05 -0.306000 1.25e-03
Citric acid cycle (TCA cycle) 34 2.02e-03 -0.306000 1.65e-02
Activation of NF-kappaB in B cells 54 1.06e-04 -0.305000 1.34e-03
RIP-mediated NFkB activation via ZBP1 17 2.97e-02 -0.305000 1.28e-01
Passive transport by Aquaporins 6 1.98e-01 0.304000 4.27e-01
Mucopolysaccharidoses 11 8.13e-02 0.303000 2.54e-01
Regulation of CDH11 gene transcription 5 2.40e-01 -0.303000 4.82e-01
Asymmetric localization of PCP proteins 49 2.38e-04 -0.303000 2.71e-03
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 1.65e-01 0.303000 3.87e-01
Removal of the Flap Intermediate 14 4.94e-02 -0.303000 1.82e-01
Respiratory electron transport 149 1.62e-10 -0.303000 4.89e-09
RHOQ GTPase cycle 55 1.08e-04 0.302000 1.36e-03
Defensins 8 1.40e-01 0.301000 3.55e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 2.03e-01 0.300000 4.34e-01
Telomere C-strand synthesis initiation 13 6.11e-02 -0.300000 2.07e-01
tRNA modification in the mitochondrion 9 1.20e-01 -0.299000 3.24e-01
Interleukin-27 signaling 11 8.59e-02 0.299000 2.61e-01
G alpha (z) signalling events 36 1.94e-03 0.298000 1.61e-02
Ribavirin ADME 11 8.76e-02 -0.297000 2.63e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 1.04e-02 -0.296000 6.17e-02
SOS-mediated signalling 7 1.76e-01 0.295000 4.00e-01
Mismatch Repair 15 4.76e-02 -0.295000 1.79e-01
Telomere C-strand (Lagging Strand) Synthesis 34 2.89e-03 -0.295000 2.26e-02
Sphingolipid de novo biosynthesis 34 2.92e-03 0.295000 2.28e-02
Condensation of Prophase Chromosomes 27 8.09e-03 0.294000 4.90e-02
Formation of ATP by chemiosmotic coupling 20 2.28e-02 -0.294000 1.08e-01
Activation of the AP-1 family of transcription factors 10 1.08e-01 0.294000 3.04e-01
Interleukin-1 processing 8 1.51e-01 -0.293000 3.69e-01
Hedgehog ligand biogenesis 47 5.03e-04 -0.293000 5.17e-03
G1/S DNA Damage Checkpoints 54 2.11e-04 -0.291000 2.46e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 6.89e-02 0.291000 2.27e-01
GDP-fucose biosynthesis 6 2.17e-01 -0.291000 4.47e-01
Platelet Aggregation (Plug Formation) 30 5.88e-03 0.291000 3.90e-02
Serine biosynthesis 8 1.55e-01 0.290000 3.76e-01
Cell surface interactions at the vascular wall 176 3.60e-11 0.289000 1.22e-09
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 4.11e-04 0.289000 4.34e-03
Pregnenolone biosynthesis 10 1.14e-01 -0.288000 3.16e-01
NADE modulates death signalling 5 2.65e-01 0.288000 5.11e-01
Removal of the Flap Intermediate from the C-strand 17 4.06e-02 -0.287000 1.63e-01
Cobalamin (Cbl) metabolism 7 1.89e-01 -0.286000 4.13e-01
Hyaluronan uptake and degradation 12 8.62e-02 0.286000 2.61e-01
RHOBTB2 GTPase cycle 23 1.81e-02 -0.285000 9.27e-02
mRNA decay by 3’ to 5’ exoribonuclease 13 7.56e-02 -0.285000 2.42e-01
TRIF-mediated programmed cell death 9 1.40e-01 -0.284000 3.55e-01
Regulation of APC/C activators between G1/S and early anaphase 68 5.15e-05 -0.284000 7.37e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 1.94e-01 0.284000 4.21e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 3.09e-09 0.283000 8.53e-08
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 1.38e-04 -0.282000 1.68e-03
Downstream TCR signaling 89 4.53e-06 -0.281000 8.47e-05
Xenobiotics 12 9.22e-02 -0.281000 2.72e-01
Metabolism of non-coding RNA 53 4.07e-04 -0.281000 4.34e-03
snRNP Assembly 53 4.07e-04 -0.281000 4.34e-03
Phosphorylation of Emi1 6 2.34e-01 0.281000 4.72e-01
Metabolism of RNA 718 3.10e-37 -0.279000 2.99e-34
Termination of translesion DNA synthesis 32 6.37e-03 -0.279000 4.09e-02
Sema4D induced cell migration and growth-cone collapse 19 3.57e-02 0.278000 1.48e-01
Aflatoxin activation and detoxification 14 7.23e-02 -0.277000 2.34e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 3.18e-02 -0.277000 1.37e-01
Signaling by LTK in cancer 7 2.04e-01 0.277000 4.36e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 2.07e-04 -0.277000 2.42e-03
TNFR2 non-canonical NF-kB pathway 84 1.14e-05 -0.277000 1.90e-04
Fructose metabolism 7 2.06e-01 -0.276000 4.37e-01
Heme biosynthesis 13 8.57e-02 -0.275000 2.61e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 2.09e-01 -0.274000 4.38e-01
PTK6 promotes HIF1A stabilization 6 2.47e-01 0.273000 4.89e-01
Signaling by Activin 14 7.71e-02 0.273000 2.46e-01
Noncanonical activation of NOTCH3 8 1.82e-01 0.273000 4.07e-01
Syndecan interactions 26 1.65e-02 0.272000 8.63e-02
RHOF GTPase cycle 39 3.55e-03 0.270000 2.62e-02
Metabolism of amino acids and derivatives 308 3.68e-16 -0.270000 2.45e-14
RHO GTPases activate IQGAPs 25 1.96e-02 0.270000 9.72e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 2.86e-02 0.270000 1.27e-01
Reactions specific to the complex N-glycan synthesis pathway 7 2.21e-01 0.267000 4.54e-01
RHOB GTPase cycle 65 1.98e-04 0.267000 2.33e-03
Signaling by Leptin 10 1.46e-01 0.265000 3.63e-01
Displacement of DNA glycosylase by APEX1 9 1.68e-01 -0.265000 3.91e-01
Signaling by EGFR 48 1.49e-03 0.265000 1.29e-02
Processive synthesis on the C-strand of the telomere 19 4.63e-02 -0.264000 1.76e-01
Alternative complement activation 5 3.09e-01 -0.263000 5.60e-01
Host Interactions of HIV factors 118 8.31e-07 -0.263000 1.87e-05
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 1.16e-01 0.262000 3.17e-01
Amino acid transport across the plasma membrane 26 2.07e-02 0.262000 1.01e-01
Germ layer formation at gastrulation 9 1.74e-01 0.261000 3.98e-01
RNA Polymerase II Transcription Termination 66 2.47e-04 -0.261000 2.79e-03
Cellular response to hypoxia 59 5.39e-04 -0.260000 5.45e-03
NFE2L2 regulating ER-stress associated genes 5 3.13e-01 0.260000 5.62e-01
Aerobic respiration and respiratory electron transport 245 2.21e-12 -0.260000 8.55e-11
Gluconeogenesis 19 4.98e-02 -0.260000 1.82e-01
RUNX3 regulates NOTCH signaling 14 9.47e-02 0.258000 2.77e-01
ECM proteoglycans 48 2.00e-03 0.258000 1.64e-02
Formation of paraxial mesoderm 52 1.33e-03 -0.257000 1.17e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 1.23e-01 0.257000 3.30e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 5.11e-04 -0.257000 5.22e-03
PKA activation 15 8.52e-02 0.257000 2.61e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 4.31e-04 -0.256000 4.48e-03
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 3.21e-01 -0.256000 5.70e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 1.16e-04 -0.256000 1.44e-03
TLR3-mediated TICAM1-dependent programmed cell death 6 2.80e-01 -0.255000 5.28e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 7.79e-02 0.255000 2.46e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 6.66e-03 -0.254000 4.23e-02
Class I peroxisomal membrane protein import 20 4.91e-02 -0.254000 1.81e-01
GRB2 events in EGFR signaling 11 1.45e-01 0.254000 3.62e-01
tRNA modification in the nucleus and cytosol 43 4.03e-03 -0.253000 2.87e-02
MET activates RAS signaling 10 1.66e-01 0.253000 3.89e-01
TCR signaling 110 4.69e-06 -0.253000 8.63e-05
Pyroptosis 25 2.89e-02 -0.252000 1.27e-01
SHC1 events in EGFR signaling 12 1.31e-01 0.252000 3.42e-01
Glycogen breakdown (glycogenolysis) 12 1.31e-01 0.252000 3.42e-01
Pyrimidine salvage 10 1.68e-01 0.252000 3.91e-01
EGFR interacts with phospholipase C-gamma 7 2.49e-01 0.251000 4.92e-01
Orc1 removal from chromatin 58 9.30e-04 -0.251000 8.64e-03
Acetylcholine regulates insulin secretion 9 1.92e-01 -0.251000 4.17e-01
Interconversion of nucleotide di- and triphosphates 27 2.39e-02 -0.251000 1.12e-01
Alpha-oxidation of phytanate 6 2.87e-01 -0.251000 5.37e-01
Insulin receptor signalling cascade 40 6.06e-03 0.251000 3.97e-02
Protein localization 157 6.73e-08 -0.250000 1.73e-06
Pexophagy 10 1.72e-01 -0.249000 3.96e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.35e-01 0.249000 3.47e-01
Transport of connexons to the plasma membrane 12 1.35e-01 0.249000 3.47e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 4.30e-02 -0.249000 1.69e-01
Mitochondrial protein degradation 96 2.46e-05 -0.249000 3.84e-04
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 6.01e-04 -0.248000 5.92e-03
Defective HLCS causes multiple carboxylase deficiency 7 2.57e-01 -0.248000 4.99e-01
RNA Polymerase I Transcription Initiation 47 3.32e-03 -0.248000 2.53e-02
Activation of PUMA and translocation to mitochondria 9 1.99e-01 0.247000 4.28e-01
RUNX2 regulates bone development 26 2.92e-02 0.247000 1.28e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.94e-04 -0.247000 3.26e-03
Leishmania infection 211 7.26e-10 0.246000 2.06e-08
Parasitic Infection Pathways 211 7.26e-10 0.246000 2.06e-08
Hedgehog ‘on’ state 65 6.09e-04 -0.246000 5.98e-03
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 4.15e-02 0.246000 1.65e-01
Cleavage of the damaged purine 22 4.62e-02 0.246000 1.76e-01
Depurination 22 4.62e-02 0.246000 1.76e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 4.62e-02 0.246000 1.76e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 2.18e-04 -0.245000 2.49e-03
Activation of AMPK downstream of NMDARs 20 5.76e-02 0.245000 2.02e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.05e-04 -0.245000 1.33e-03
SARS-CoV-1 Infection 138 7.16e-07 -0.244000 1.67e-05
PKA activation in glucagon signalling 14 1.14e-01 0.244000 3.16e-01
Phospholipase C-mediated cascade; FGFR4 6 3.01e-01 -0.244000 5.50e-01
RHOC GTPase cycle 72 3.54e-04 0.243000 3.85e-03
The activation of arylsulfatases 10 1.84e-01 0.243000 4.08e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 7.59e-02 -0.242000 2.43e-01
Complex IV assembly 45 5.17e-03 -0.241000 3.51e-02
rRNA processing in the mitochondrion 24 4.11e-02 0.241000 1.64e-01
Regulation of signaling by NODAL 6 3.08e-01 0.240000 5.59e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 1.88e-01 -0.240000 4.13e-01
Interleukin-35 Signalling 12 1.50e-01 0.240000 3.68e-01
Recognition of DNA damage by PCNA-containing replication complex 30 2.31e-02 -0.240000 1.09e-01
MET promotes cell motility 33 1.72e-02 0.240000 8.90e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 1.69e-01 -0.240000 3.92e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.69e-01 0.239000 3.93e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 2.41e-01 0.239000 4.83e-01
Olfactory Signaling Pathway 61 1.25e-03 0.239000 1.12e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 1.36e-01 -0.239000 3.48e-01
ER-Phagosome pathway 75 3.60e-04 -0.238000 3.88e-03
RHOD GTPase cycle 50 3.57e-03 0.238000 2.62e-02
Signaling by Hippo 18 8.18e-02 0.237000 2.54e-01
PI-3K cascade:FGFR4 11 1.74e-01 0.237000 3.98e-01
NOTCH2 intracellular domain regulates transcription 11 1.74e-01 0.237000 3.98e-01
Transcriptional regulation of pluripotent stem cells 21 6.04e-02 0.237000 2.06e-01
Advanced glycosylation endproduct receptor signaling 12 1.56e-01 0.237000 3.77e-01
Protein hydroxylation 17 9.13e-02 -0.237000 2.71e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 2.79e-01 0.236000 5.28e-01
TGFBR3 PTM regulation 10 1.96e-01 0.236000 4.26e-01
MAPK1 (ERK2) activation 9 2.21e-01 0.235000 4.55e-01
FRS-mediated FGFR1 signaling 15 1.15e-01 0.235000 3.16e-01
SLC15A4:TASL-dependent IRF5 activation 6 3.19e-01 0.235000 5.67e-01
Apoptotic cleavage of cellular proteins 35 1.62e-02 0.235000 8.55e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 2.50e-01 0.235000 4.93e-01
ZBP1(DAI) mediated induction of type I IFNs 20 6.91e-02 -0.235000 2.27e-01
Signaling by activated point mutants of FGFR1 5 3.64e-01 0.235000 6.04e-01
Condensation of Prometaphase Chromosomes 11 1.79e-01 0.234000 4.02e-01
mRNA 3’-end processing 57 2.24e-03 -0.234000 1.81e-02
Activated NTRK2 signals through FRS2 and FRS3 8 2.52e-01 0.234000 4.95e-01
Switching of origins to a post-replicative state 79 3.31e-04 -0.234000 3.64e-03
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.48e-03 -0.233000 1.29e-02
Uptake and function of anthrax toxins 11 1.81e-01 0.233000 4.06e-01
Membrane binding and targetting of GAG proteins 13 1.46e-01 -0.233000 3.62e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 1.46e-01 -0.233000 3.62e-01
Laminin interactions 26 4.01e-02 0.233000 1.62e-01
VEGF binds to VEGFR leading to receptor dimerization 5 3.68e-01 0.233000 6.06e-01
VEGF ligand-receptor interactions 5 3.68e-01 0.233000 6.06e-01
Triglyceride biosynthesis 10 2.03e-01 0.232000 4.34e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.08e-01 -0.232000 3.04e-01
Establishment of Sister Chromatid Cohesion 11 1.83e-01 0.232000 4.07e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 6.07e-02 0.231000 2.06e-01
Downstream signaling events of B Cell Receptor (BCR) 68 9.92e-04 -0.231000 9.17e-03
Regulation of TP53 Activity through Methylation 19 8.17e-02 -0.231000 2.54e-01
Degradation of beta-catenin by the destruction complex 72 7.18e-04 -0.231000 6.90e-03
Interactions of Vpr with host cellular proteins 37 1.53e-02 -0.230000 8.26e-02
The NLRP3 inflammasome 16 1.11e-01 -0.230000 3.11e-01
Calcitonin-like ligand receptors 5 3.73e-01 0.230000 6.11e-01
Pre-NOTCH Transcription and Translation 47 6.46e-03 0.230000 4.13e-02
CLEC7A/inflammasome pathway 6 3.31e-01 -0.229000 5.81e-01
Regulation of PTEN stability and activity 55 3.28e-03 -0.229000 2.53e-02
Cleavage of the damaged pyrimidine 27 3.94e-02 0.229000 1.60e-01
Depyrimidination 27 3.94e-02 0.229000 1.60e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 3.94e-02 0.229000 1.60e-01
Small interfering RNA (siRNA) biogenesis 9 2.35e-01 0.229000 4.73e-01
PI3K events in ERBB2 signaling 11 1.89e-01 0.229000 4.13e-01
Downregulation of ERBB2:ERBB3 signaling 12 1.72e-01 -0.228000 3.96e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 1.55e-02 0.227000 8.27e-02
Nucleosome assembly 38 1.55e-02 0.227000 8.27e-02
Regulation of RAS by GAPs 55 3.62e-03 -0.227000 2.63e-02
Defects in cobalamin (B12) metabolism 13 1.58e-01 -0.226000 3.79e-01
Sema4D in semaphorin signaling 22 6.64e-02 0.226000 2.21e-01
Glycosphingolipid transport 7 3.01e-01 -0.226000 5.50e-01
ADORA2B mediated anti-inflammatory cytokines production 36 1.94e-02 0.225000 9.66e-02
Activated NTRK3 signals through PI3K 5 3.84e-01 0.225000 6.20e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.26e-02 -0.224000 2.09e-01
SARS-CoV-2 modulates autophagy 11 1.99e-01 -0.224000 4.28e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 2.45e-01 -0.224000 4.87e-01
Presynaptic depolarization and calcium channel opening 8 2.74e-01 -0.223000 5.20e-01
CLEC7A (Dectin-1) signaling 86 3.48e-04 -0.223000 3.80e-03
Polo-like kinase mediated events 16 1.23e-01 0.222000 3.32e-01
Evasion by RSV of host interferon responses 20 8.51e-02 -0.222000 2.61e-01
Regulation of localization of FOXO transcription factors 11 2.02e-01 0.222000 4.32e-01
APC/C-mediated degradation of cell cycle proteins 75 8.85e-04 -0.222000 8.30e-03
Regulation of mitotic cell cycle 75 8.85e-04 -0.222000 8.30e-03
Defective RIPK1-mediated regulated necrosis 7 3.10e-01 -0.222000 5.60e-01
Activation of G protein gated Potassium channels 20 8.61e-02 0.222000 2.61e-01
G protein gated Potassium channels 20 8.61e-02 0.222000 2.61e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 8.61e-02 0.222000 2.61e-01
Beta-catenin phosphorylation cascade 17 1.15e-01 0.221000 3.16e-01
Synthesis of DNA 108 7.81e-05 -0.220000 1.04e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 59 3.53e-03 -0.220000 2.62e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 4.46e-02 -0.219000 1.73e-01
PI3K Cascade 31 3.47e-02 0.219000 1.46e-01
Signaling by Retinoic Acid 29 4.11e-02 -0.219000 1.64e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 2.96e-02 0.219000 1.28e-01
Nucleotide Excision Repair 108 8.49e-05 -0.219000 1.11e-03
Defects in vitamin and cofactor metabolism 21 8.29e-02 -0.219000 2.57e-01
Negative feedback regulation of MAPK pathway 6 3.54e-01 0.219000 5.98e-01
Glucagon signaling in metabolic regulation 26 5.39e-02 0.218000 1.92e-01
Transport of Mature Transcript to Cytoplasm 81 6.83e-04 -0.218000 6.63e-03
Expression and translocation of olfactory receptors 56 4.76e-03 0.218000 3.27e-02
FOXO-mediated transcription of cell cycle genes 15 1.44e-01 0.218000 3.61e-01
ADP signalling through P2Y purinoceptor 12 18 1.09e-01 0.218000 3.07e-01
Translesion Synthesis by POLH 18 1.09e-01 -0.218000 3.07e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 1.44e-01 -0.218000 3.62e-01
Dual incision in TC-NER 63 2.80e-03 -0.218000 2.22e-02
ABC transporter disorders 60 3.55e-03 -0.218000 2.62e-02
Vpr-mediated nuclear import of PICs 34 2.89e-02 -0.217000 1.27e-01
rRNA modification in the mitochondrion 8 2.90e-01 -0.216000 5.39e-01
CREB3 factors activate genes 6 3.60e-01 0.216000 6.01e-01
RHOG GTPase cycle 71 1.73e-03 0.215000 1.47e-02
Synthesis of PIPs at the plasma membrane 52 7.30e-03 0.215000 4.56e-02
DNA Damage Recognition in GG-NER 38 2.19e-02 -0.215000 1.05e-01
Interactions of Rev with host cellular proteins 37 2.40e-02 -0.214000 1.12e-01
NPAS4 regulates expression of target genes 16 1.38e-01 0.214000 3.51e-01
Apoptotic execution phase 46 1.21e-02 0.214000 6.95e-02
Myoclonic epilepsy of Lafora 8 2.96e-01 -0.213000 5.46e-01
Cellular response to mitochondrial stress 9 2.68e-01 -0.213000 5.16e-01
Meiotic recombination 37 2.51e-02 0.213000 1.15e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 2.44e-01 0.213000 4.86e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 2.02e-01 0.213000 4.33e-01
Phospholipase C-mediated cascade; FGFR2 8 2.99e-01 -0.212000 5.49e-01
Bicarbonate transporters 9 2.71e-01 -0.212000 5.19e-01
Nuclear import of Rev protein 34 3.27e-02 -0.212000 1.39e-01
Formation of definitive endoderm 9 2.72e-01 0.212000 5.19e-01
RAB geranylgeranylation 61 4.29e-03 0.211000 3.01e-02
Interferon gamma signaling 90 5.27e-04 -0.211000 5.36e-03
Defective GALNT3 causes HFTC 9 2.72e-01 0.211000 5.19e-01
Platelet degranulation 106 1.81e-04 0.210000 2.14e-03
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 3.35e-01 -0.210000 5.83e-01
Urea cycle 7 3.35e-01 0.210000 5.83e-01
Sphingolipid metabolism 91 5.42e-04 0.210000 5.45e-03
Serotonin Neurotransmitter Release Cycle 15 1.60e-01 -0.209000 3.82e-01
SUMOylation of immune response proteins 12 2.09e-01 -0.209000 4.38e-01
Downregulation of ERBB4 signaling 8 3.06e-01 -0.209000 5.58e-01
Formation of Incision Complex in GG-NER 43 1.77e-02 -0.209000 9.15e-02
Signaling by MET 68 3.01e-03 0.208000 2.33e-02
Signalling to ERKs 32 4.19e-02 0.208000 1.65e-01
Antigen processing-Cross presentation 89 7.08e-04 -0.208000 6.84e-03
Activation of C3 and C5 7 3.42e-01 0.208000 5.91e-01
Miscellaneous transport and binding events 20 1.09e-01 0.207000 3.06e-01
RNA Polymerase I Transcription Termination 30 4.97e-02 -0.207000 1.82e-01
Cargo trafficking to the periciliary membrane 47 1.43e-02 -0.207000 7.96e-02
Dectin-2 family 19 1.20e-01 0.206000 3.24e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 2.79e-02 0.206000 1.25e-01
Defects in biotin (Btn) metabolism 8 3.13e-01 -0.206000 5.62e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 1.84e-01 0.205000 4.09e-01
Synthesis of PI 5 4.28e-01 -0.205000 6.55e-01
FGFR2 mutant receptor activation 23 8.94e-02 -0.205000 2.66e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 1.45e-01 -0.204000 3.62e-01
Response to elevated platelet cytosolic Ca2+ 110 2.13e-04 0.204000 2.46e-03
IGF1R signaling cascade 38 2.94e-02 0.204000 1.28e-01
HDL assembly 6 3.87e-01 0.204000 6.20e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 3.87e-01 -0.204000 6.20e-01
rRNA modification in the nucleus and cytosol 59 6.81e-03 -0.204000 4.31e-02
IRS-related events triggered by IGF1R 37 3.22e-02 0.203000 1.38e-01
Biotin transport and metabolism 11 2.43e-01 -0.203000 4.84e-01
Nephrin family interactions 20 1.16e-01 0.203000 3.17e-01
Signaling by FGFR2 IIIa TM 18 1.36e-01 -0.203000 3.48e-01
Phase 3 - rapid repolarisation 6 3.90e-01 -0.203000 6.23e-01
Gamma-carboxylation of protein precursors 6 3.90e-01 -0.203000 6.23e-01
HIV Infection 213 3.52e-07 -0.202000 8.39e-06
Intraflagellar transport 47 1.64e-02 -0.202000 8.61e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 4.42e-02 -0.202000 1.73e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 3.58e-02 -0.202000 1.48e-01
Impaired BRCA2 binding to PALB2 24 8.66e-02 0.202000 2.61e-01
Activation of the phototransduction cascade 8 3.22e-01 0.202000 5.71e-01
Signaling by PDGF 50 1.35e-02 0.202000 7.61e-02
Cyclin A:Cdk2-associated events at S phase entry 75 2.49e-03 -0.202000 2.00e-02
SHC1 events in ERBB2 signaling 17 1.51e-01 0.201000 3.69e-01
Long-term potentiation 18 1.39e-01 -0.201000 3.53e-01
Activation of GABAB receptors 31 5.31e-02 0.201000 1.91e-01
GABA B receptor activation 31 5.31e-02 0.201000 1.91e-01
Netrin-1 signaling 35 4.00e-02 0.201000 1.62e-01
Attachment of GPI anchor to uPAR 7 3.58e-01 -0.201000 6.00e-01
Viral Messenger RNA Synthesis 44 2.16e-02 -0.200000 1.04e-01
Pre-NOTCH Expression and Processing 63 6.03e-03 0.200000 3.97e-02
Signaling by Insulin receptor 63 6.07e-03 0.200000 3.97e-02
Eicosanoid ligand-binding receptors 13 2.13e-01 0.200000 4.41e-01
DNA Damage Bypass 47 1.80e-02 -0.199000 9.26e-02
Cellular response to heat stress 94 8.34e-04 -0.199000 7.94e-03
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 1.55e-01 0.199000 3.75e-01
GABA receptor activation 38 3.36e-02 0.199000 1.42e-01
STAT5 activation downstream of FLT3 ITD mutants 9 3.01e-01 0.199000 5.50e-01
Formation of the Early Elongation Complex 33 4.81e-02 -0.199000 1.80e-01
Formation of the HIV-1 Early Elongation Complex 33 4.81e-02 -0.199000 1.80e-01
Fertilization 12 2.33e-01 -0.199000 4.72e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 3.99e-01 -0.199000 6.29e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 4.51e-02 0.199000 1.73e-01
Regulation of IFNA/IFNB signaling 12 2.34e-01 -0.198000 4.72e-01
SARS-CoV-2-host interactions 183 3.75e-06 -0.198000 7.33e-05
Regulation of Expression and Function of Type II Classical Cadherins 25 8.65e-02 -0.198000 2.61e-01
Regulation of Homotypic Cell-Cell Adhesion 25 8.65e-02 -0.198000 2.61e-01
Maternal to zygotic transition (MZT) 72 3.68e-03 0.198000 2.66e-02
IRS-mediated signalling 35 4.27e-02 0.198000 1.68e-01
Androgen biosynthesis 5 4.44e-01 -0.198000 6.67e-01
Aquaporin-mediated transport 38 3.49e-02 0.198000 1.46e-01
Resolution of D-Loop Structures 35 4.31e-02 0.198000 1.69e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.86e-01 0.197000 4.09e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 1.86e-01 0.197000 4.09e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 1.86e-01 0.197000 4.09e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 1.86e-01 0.197000 4.09e-01
Signaling by CTNNB1 phospho-site mutants 15 1.86e-01 0.197000 4.09e-01
Signaling by GSK3beta mutants 15 1.86e-01 0.197000 4.09e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 2.01e-01 0.197000 4.32e-01
ISG15 antiviral mechanism 72 3.81e-03 -0.197000 2.74e-02
Arachidonate production from DAG 5 4.46e-01 0.197000 6.70e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 1.87e-01 -0.197000 4.12e-01
RHO GTPases Activate ROCKs 18 1.49e-01 0.196000 3.67e-01
Transcriptional Regulation by VENTX 39 3.39e-02 -0.196000 1.43e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 1.45e-02 0.196000 8.04e-02
Extension of Telomeres 51 1.55e-02 -0.196000 8.27e-02
Inwardly rectifying K+ channels 24 9.67e-02 0.196000 2.80e-01
Nuclear events stimulated by ALK signaling in cancer 33 5.18e-02 -0.196000 1.88e-01
TNFR1-induced NF-kappa-B signaling pathway 32 5.59e-02 -0.195000 1.97e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 9.11e-02 -0.195000 2.71e-01
Norepinephrine Neurotransmitter Release Cycle 14 2.06e-01 -0.195000 4.37e-01
Synthesis of PE 12 2.42e-01 0.195000 4.83e-01
Cyclin E associated events during G1/S transition 73 3.99e-03 -0.195000 2.86e-02
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 1.94e-03 0.194000 1.61e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 1.94e-03 0.194000 1.61e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 1.94e-03 0.194000 1.61e-02
Downstream signaling of activated FGFR3 17 1.66e-01 0.194000 3.89e-01
Hyaluronan metabolism 16 1.80e-01 0.193000 4.06e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 4.46e-02 0.193000 1.73e-01
Chaperone Mediated Autophagy 20 1.34e-01 -0.193000 3.46e-01
APC truncation mutants have impaired AXIN binding 14 2.11e-01 0.193000 4.38e-01
AXIN missense mutants destabilize the destruction complex 14 2.11e-01 0.193000 4.38e-01
Signaling by AMER1 mutants 14 2.11e-01 0.193000 4.38e-01
Signaling by APC mutants 14 2.11e-01 0.193000 4.38e-01
Signaling by AXIN mutants 14 2.11e-01 0.193000 4.38e-01
Truncations of AMER1 destabilize the destruction complex 14 2.11e-01 0.193000 4.38e-01
HIV Transcription Initiation 45 2.51e-02 -0.193000 1.15e-01
RNA Polymerase II HIV Promoter Escape 45 2.51e-02 -0.193000 1.15e-01
RNA Polymerase II Promoter Escape 45 2.51e-02 -0.193000 1.15e-01
RNA Polymerase II Transcription Initiation 45 2.51e-02 -0.193000 1.15e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 2.51e-02 -0.193000 1.15e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 2.51e-02 -0.193000 1.15e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 4.14e-01 -0.193000 6.42e-01
Cytosolic sulfonation of small molecules 18 1.57e-01 0.192000 3.79e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 3.78e-01 -0.192000 6.16e-01
Platelet activation, signaling and aggregation 223 7.45e-07 0.192000 1.71e-05
Loss of Function of SMAD2/3 in Cancer 7 3.79e-01 0.192000 6.17e-01
Hedgehog ‘off’ state 91 1.57e-03 -0.192000 1.34e-02
PKA-mediated phosphorylation of CREB 17 1.71e-01 0.192000 3.96e-01
Synthesis of pyrophosphates in the cytosol 8 3.49e-01 0.191000 5.98e-01
Formation of TC-NER Pre-Incision Complex 51 1.85e-02 -0.191000 9.39e-02
tRNA processing in the nucleus 59 1.14e-02 -0.190000 6.65e-02
MAPK6/MAPK4 signaling 69 6.26e-03 -0.190000 4.05e-02
Glutathione synthesis and recycling 10 3.00e-01 -0.189000 5.49e-01
Interleukin-9 signaling 8 3.54e-01 -0.189000 5.98e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 4.63e-01 0.189000 6.84e-01
Synthesis of Dolichyl-phosphate 6 4.23e-01 -0.189000 6.48e-01
Postmitotic nuclear pore complex (NPC) reformation 27 8.91e-02 -0.189000 2.66e-01
Signaling by FLT3 ITD and TKD mutants 15 2.05e-01 0.189000 4.37e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 2.79e-01 0.188000 5.28e-01
Sulfide oxidation to sulfate 5 4.67e-01 -0.188000 6.86e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.81e-01 0.188000 5.30e-01
Budding and maturation of HIV virion 26 9.89e-02 -0.187000 2.85e-01
Rev-mediated nuclear export of HIV RNA 35 5.56e-02 -0.187000 1.97e-01
Alpha-protein kinase 1 signaling pathway 11 2.83e-01 -0.187000 5.32e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 8.16e-02 -0.187000 2.54e-01
Hemostasis 562 3.63e-14 0.187000 1.75e-12
Signaling by NOTCH4 70 6.90e-03 -0.187000 4.35e-02
Pausing and recovery of Tat-mediated HIV elongation 30 7.73e-02 -0.186000 2.46e-01
Tat-mediated HIV elongation arrest and recovery 30 7.73e-02 -0.186000 2.46e-01
PRC2 methylates histones and DNA 27 9.41e-02 0.186000 2.76e-01
Regulation of HSF1-mediated heat shock response 79 4.30e-03 -0.186000 3.01e-02
Loss of Function of TGFBR1 in Cancer 7 3.95e-01 0.185000 6.26e-01
Maturation of spike protein 9683686 5 4.73e-01 0.185000 6.90e-01
Interleukin-37 signaling 19 1.62e-01 0.185000 3.83e-01
Glycosaminoglycan metabolism 98 1.52e-03 0.185000 1.31e-02
Regulated Necrosis 56 1.65e-02 -0.185000 8.63e-02
Synthesis of PC 23 1.25e-01 0.185000 3.33e-01
Aspartate and asparagine metabolism 9 3.39e-01 -0.184000 5.88e-01
Plasma lipoprotein remodeling 18 1.77e-01 0.184000 4.00e-01
Base-Excision Repair, AP Site Formation 29 8.66e-02 0.184000 2.61e-01
Interferon Signaling 240 9.51e-07 -0.184000 2.11e-05
Interleukin-10 signaling 38 5.04e-02 -0.183000 1.83e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 2.52e-01 -0.183000 4.95e-01
Disorders of Developmental Biology 12 2.72e-01 -0.183000 5.19e-01
Disorders of Nervous System Development 12 2.72e-01 -0.183000 5.19e-01
Loss of function of MECP2 in Rett syndrome 12 2.72e-01 -0.183000 5.19e-01
Pervasive developmental disorders 12 2.72e-01 -0.183000 5.19e-01
PI-3K cascade:FGFR2 13 2.54e-01 0.183000 4.97e-01
Metabolism of nucleotides 85 3.61e-03 -0.183000 2.63e-02
GPER1 signaling 38 5.23e-02 0.182000 1.88e-01
Maturation of spike protein 9694548 36 5.89e-02 0.182000 2.05e-01
Sphingolipid catabolism 11 2.97e-01 0.182000 5.48e-01
Metabolism of porphyrins 23 1.32e-01 -0.182000 3.42e-01
Integrin signaling 22 1.41e-01 0.181000 3.56e-01
RUNX3 regulates CDKN1A transcription 7 4.07e-01 0.181000 6.37e-01
RUNX2 regulates osteoblast differentiation 21 1.51e-01 0.181000 3.71e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 3.76e-01 0.181000 6.14e-01
RHO GTPases activate PAKs 20 1.63e-01 0.180000 3.84e-01
Netrin mediated repulsion signals 5 4.86e-01 -0.180000 6.99e-01
PCP/CE pathway 75 7.10e-03 -0.180000 4.47e-02
Negative regulators of DDX58/IFIH1 signaling 34 7.02e-02 -0.179000 2.29e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 4.47e-01 0.179000 6.70e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 4.47e-01 0.179000 6.70e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 7.99e-02 -0.179000 2.51e-01
DCC mediated attractive signaling 13 2.65e-01 0.179000 5.11e-01
Cell-extracellular matrix interactions 16 2.17e-01 0.178000 4.47e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 5.43e-02 0.178000 1.93e-01
Sodium/Calcium exchangers 9 3.55e-01 0.178000 5.98e-01
ABC-family proteins mediated transport 81 5.65e-03 -0.178000 3.81e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 2.78e-05 0.178000 4.23e-04
Depolymerization of the Nuclear Lamina 15 2.34e-01 0.178000 4.72e-01
Assembly Of The HIV Virion 15 2.34e-01 -0.177000 4.72e-01
Downstream signaling of activated FGFR1 22 1.50e-01 0.177000 3.69e-01
Interleukin-20 family signaling 17 2.07e-01 -0.177000 4.37e-01
RAS signaling downstream of NF1 loss-of-function variants 7 4.18e-01 0.177000 6.45e-01
Cytosolic sensors of pathogen-associated DNA 63 1.52e-02 -0.177000 8.24e-02
FRS-mediated FGFR3 signaling 12 2.91e-01 0.176000 5.41e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 3.17e-02 0.176000 1.36e-01
PTEN Regulation 127 6.33e-04 -0.176000 6.17e-03
Collagen degradation 44 4.51e-02 0.175000 1.73e-01
HS-GAG biosynthesis 20 1.78e-01 0.174000 4.01e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.32e-01 0.174000 3.42e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.32e-01 0.174000 3.42e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.32e-01 0.174000 3.42e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.32e-01 0.174000 3.42e-01
Costimulation by the CD28 family 74 9.67e-03 -0.174000 5.77e-02
Biosynthesis of E-series 18(S)-resolvins 5 5.01e-01 0.174000 7.13e-01
Late endosomal microautophagy 30 9.99e-02 -0.174000 2.87e-01
SUMOylation of SUMOylation proteins 35 7.75e-02 -0.172000 2.46e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 7.37e-02 0.172000 2.37e-01
Amine ligand-binding receptors 10 3.48e-01 -0.171000 5.97e-01
Diseases of Base Excision Repair 5 5.07e-01 -0.171000 7.17e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 1.24e-01 0.171000 3.32e-01
Processing of Capped Intronless Pre-mRNA 29 1.11e-01 -0.171000 3.11e-01
HIV Life Cycle 144 4.09e-04 -0.171000 4.34e-03
Activation of Matrix Metalloproteinases 22 1.67e-01 0.170000 3.90e-01
Signaling by WNT in cancer 30 1.07e-01 0.170000 3.04e-01
Sensing of DNA Double Strand Breaks 6 4.72e-01 -0.170000 6.90e-01
Semaphorin interactions 56 2.87e-02 0.169000 1.27e-01
Suppression of phagosomal maturation 12 3.13e-01 -0.168000 5.62e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.34e-01 -0.168000 5.83e-01
Kidney development 17 2.30e-01 0.168000 4.68e-01
Histidine catabolism 7 4.42e-01 0.168000 6.66e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 6.00e-02 -0.168000 2.06e-01
HIV Transcription Elongation 42 6.00e-02 -0.168000 2.06e-01
Tat-mediated elongation of the HIV-1 transcript 42 6.00e-02 -0.168000 2.06e-01
Regulation of CDH11 function 10 3.59e-01 -0.167000 6.00e-01
Gain-of-function MRAS complexes activate RAF signaling 8 4.12e-01 -0.167000 6.41e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 4.12e-01 -0.167000 6.41e-01
Signaling by MRAS-complex mutants 8 4.12e-01 -0.167000 6.41e-01
NS1 Mediated Effects on Host Pathways 40 6.71e-02 -0.167000 2.22e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 1.32e-01 -0.167000 3.42e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.32e-01 -0.167000 3.42e-01
Regulation of TP53 Activity through Acetylation 29 1.19e-01 -0.167000 3.24e-01
Neurotoxicity of clostridium toxins 9 3.86e-01 -0.167000 6.20e-01
G1/S-Specific Transcription 29 1.20e-01 0.167000 3.24e-01
HDR through MMEJ (alt-NHEJ) 12 3.17e-01 -0.167000 5.66e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 4.46e-01 0.166000 6.70e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 2.23e-01 -0.166000 4.56e-01
Effects of PIP2 hydrolysis 24 1.60e-01 0.166000 3.82e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 4.48e-01 -0.166000 6.70e-01
FLT3 signaling by CBL mutants 7 4.48e-01 -0.166000 6.70e-01
Glycosphingolipid catabolism 31 1.12e-01 0.165000 3.12e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 9.68e-02 0.165000 2.80e-01
UCH proteinases 73 1.52e-02 -0.164000 8.24e-02
Unwinding of DNA 12 3.25e-01 0.164000 5.74e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 3.94e-01 -0.164000 6.26e-01
Negative regulation of the PI3K/AKT network 93 6.32e-03 0.164000 4.07e-02
Negative regulation of FGFR1 signaling 25 1.57e-01 0.164000 3.79e-01
E2F-enabled inhibition of pre-replication complex formation 9 3.96e-01 0.163000 6.26e-01
Degradation of the extracellular matrix 99 5.02e-03 0.163000 3.43e-02
Activation of BAD and translocation to mitochondria 15 2.74e-01 0.163000 5.20e-01
COPI-independent Golgi-to-ER retrograde traffic 45 5.89e-02 0.163000 2.05e-01
Mitochondrial calcium ion transport 22 1.87e-01 -0.162000 4.12e-01
p75NTR negatively regulates cell cycle via SC1 5 5.29e-01 -0.162000 7.38e-01
Adenylate cyclase inhibitory pathway 11 3.51e-01 0.162000 5.98e-01
Regulation of CDH11 Expression and Function 23 1.79e-01 -0.162000 4.02e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 4.29e-01 0.162000 6.55e-01
DNA strand elongation 32 1.15e-01 -0.161000 3.16e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 3.15e-01 0.161000 5.64e-01
TNFR1-induced proapoptotic signaling 24 1.73e-01 -0.161000 3.98e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.74e-01 -0.160000 3.98e-01
CS/DS degradation 9 4.06e-01 0.160000 6.36e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 2.83e-01 -0.160000 5.32e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 1.31e-01 0.159000 3.42e-01
Erythropoietin activates RAS 13 3.20e-01 0.159000 5.69e-01
Nucleotide salvage 21 2.08e-01 -0.159000 4.38e-01
DARPP-32 events 22 1.98e-01 0.159000 4.27e-01
Defective C1GALT1C1 causes TNPS 10 3.85e-01 0.159000 6.20e-01
Basigin interactions 23 1.88e-01 0.158000 4.13e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.54e-01 0.158000 3.75e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.16e-01 -0.158000 3.17e-01
Cohesin Loading onto Chromatin 10 3.87e-01 0.158000 6.20e-01
Calcineurin activates NFAT 9 4.12e-01 0.158000 6.41e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 1.23e-03 0.158000 1.11e-02
Formation of the cornified envelope 36 1.02e-01 0.158000 2.91e-01
mRNA Capping 29 1.42e-01 -0.158000 3.57e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.23e-01 -0.157000 4.56e-01
Tie2 Signaling 16 2.77e-01 0.157000 5.23e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.64e-01 -0.156000 5.11e-01
IFNG signaling activates MAPKs 8 4.44e-01 0.156000 6.67e-01
Neutrophil degranulation 458 9.82e-09 0.156000 2.63e-07
Vitamin D (calciferol) metabolism 11 3.70e-01 -0.156000 6.07e-01
FGFR1 mutant receptor activation 25 1.77e-01 0.156000 4.01e-01
Defective pyroptosis 27 1.61e-01 0.156000 3.82e-01
SHC-mediated cascade:FGFR1 13 3.32e-01 0.156000 5.81e-01
Signal amplification 28 1.55e-01 0.155000 3.75e-01
RNA Polymerase II Pre-transcription Events 77 1.84e-02 -0.155000 9.39e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 3.96e-01 0.155000 6.26e-01
Triglyceride metabolism 26 1.71e-01 0.155000 3.96e-01
Extracellular matrix organization 222 7.01e-05 0.155000 9.64e-04
Regulation of IFNG signaling 14 3.16e-01 0.155000 5.65e-01
Transport of the SLBP Dependant Mature mRNA 36 1.08e-01 -0.155000 3.05e-01
Regulation of beta-cell development 22 2.09e-01 0.155000 4.38e-01
Vitamin B5 (pantothenate) metabolism 20 2.31e-01 -0.155000 4.69e-01
RHO GTPase Effectors 258 1.88e-05 0.155000 2.98e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 3.54e-01 0.155000 5.98e-01
Golgi Associated Vesicle Biogenesis 55 4.74e-02 0.155000 1.79e-01
Regulation of PTEN gene transcription 59 4.06e-02 -0.154000 1.63e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.32e-01 -0.154000 3.42e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.32e-01 -0.154000 3.42e-01
DNA Damage/Telomere Stress Induced Senescence 42 8.45e-02 0.154000 2.60e-01
ERBB2 Activates PTK6 Signaling 8 4.51e-01 0.154000 6.74e-01
FCERI mediated NF-kB activation 129 2.56e-03 0.154000 2.04e-02
Heparan sulfate/heparin (HS-GAG) metabolism 40 9.25e-02 0.154000 2.73e-01
VxPx cargo-targeting to cilium 19 2.47e-01 0.154000 4.89e-01
Other interleukin signaling 19 2.47e-01 -0.153000 4.89e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 4.18e-02 0.153000 1.65e-01
Retrograde neurotrophin signalling 12 3.60e-01 0.153000 6.00e-01
Fc epsilon receptor (FCERI) signaling 179 4.23e-04 0.153000 4.42e-03
Glycosphingolipid metabolism 46 7.33e-02 0.153000 2.37e-01
Signaling by NOTCH3 44 8.03e-02 0.152000 2.52e-01
Axonal growth inhibition (RHOA activation) 7 4.85e-01 0.152000 6.99e-01
p75NTR regulates axonogenesis 7 4.85e-01 0.152000 6.99e-01
Transport of the SLBP independent Mature mRNA 35 1.19e-01 -0.152000 3.23e-01
Formation of RNA Pol II elongation complex 56 4.86e-02 -0.152000 1.81e-01
RNA Polymerase II Transcription Elongation 56 4.86e-02 -0.152000 1.81e-01
Biosynthesis of maresin-like SPMs 5 5.55e-01 -0.152000 7.57e-01
Protein methylation 15 3.07e-01 -0.152000 5.59e-01
C-type lectin receptors (CLRs) 118 4.27e-03 -0.152000 3.01e-02
IRAK1 recruits IKK complex 14 3.26e-01 0.152000 5.74e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 3.26e-01 0.152000 5.74e-01
Activation of kainate receptors upon glutamate binding 26 1.82e-01 0.151000 4.07e-01
Phosphorylation of the APC/C 20 2.42e-01 -0.151000 4.83e-01
CRMPs in Sema3A signaling 13 3.46e-01 0.151000 5.95e-01
Smooth Muscle Contraction 34 1.29e-01 0.150000 3.42e-01
Endosomal/Vacuolar pathway 12 3.69e-01 -0.150000 6.06e-01
Signaling by PDGFRA extracellular domain mutants 12 3.69e-01 0.150000 6.06e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.69e-01 0.150000 6.06e-01
Diseases associated with glycosaminoglycan metabolism 25 1.95e-01 0.150000 4.23e-01
STING mediated induction of host immune responses 15 3.16e-01 -0.150000 5.65e-01
Intrinsic Pathway of Fibrin Clot Formation 15 3.16e-01 0.150000 5.65e-01
Azathioprine ADME 21 2.36e-01 -0.149000 4.75e-01
CDC6 association with the ORC:origin complex 8 4.65e-01 0.149000 6.85e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.71e-01 -0.149000 6.08e-01
Attachment and Entry 9694614 14 3.35e-01 -0.149000 5.83e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 1.71e-02 0.149000 8.86e-02
Keratan sulfate/keratin metabolism 28 1.73e-01 0.149000 3.98e-01
SUMOylation of RNA binding proteins 47 7.79e-02 -0.149000 2.46e-01
CD209 (DC-SIGN) signaling 20 2.51e-01 -0.148000 4.94e-01
Recycling pathway of L1 40 1.05e-01 0.148000 3.00e-01
Insulin receptor recycling 24 2.10e-01 0.148000 4.38e-01
MASTL Facilitates Mitotic Progression 10 4.19e-01 0.148000 6.45e-01
Late Phase of HIV Life Cycle 131 3.55e-03 -0.147000 2.62e-02
Adrenaline,noradrenaline inhibits insulin secretion 24 2.11e-01 0.147000 4.38e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 5.33e-01 0.147000 7.41e-01
Prolactin receptor signaling 12 3.78e-01 -0.147000 6.16e-01
GRB2 events in ERBB2 signaling 11 4.00e-01 0.147000 6.29e-01
FOXO-mediated transcription of cell death genes 16 3.11e-01 0.146000 5.60e-01
G0 and Early G1 27 1.89e-01 0.146000 4.13e-01
RSV-host interactions 78 2.62e-02 -0.146000 1.19e-01
Ethanol oxidation 8 4.78e-01 -0.145000 6.94e-01
Signaling by FGFR1 in disease 32 1.58e-01 0.144000 3.79e-01
G beta:gamma signalling through PI3Kgamma 22 2.42e-01 0.144000 4.83e-01
Negative regulation of MET activity 18 2.91e-01 0.144000 5.41e-01
Base Excision Repair 57 6.12e-02 -0.143000 2.07e-01
SUMOylation of DNA methylation proteins 16 3.22e-01 -0.143000 5.71e-01
Signaling by TGF-beta Receptor Complex 91 1.84e-02 0.143000 9.39e-02
Peroxisomal protein import 58 5.98e-02 -0.143000 2.06e-01
Repression of WNT target genes 14 3.55e-01 -0.143000 5.98e-01
Detoxification of Reactive Oxygen Species 30 1.76e-01 -0.143000 4.00e-01
Trafficking of GluR2-containing AMPA receptors 11 4.13e-01 0.142000 6.41e-01
Ephrin signaling 18 2.96e-01 -0.142000 5.47e-01
Lysosphingolipid and LPA receptors 11 4.15e-01 -0.142000 6.42e-01
FOXO-mediated transcription 58 6.14e-02 0.142000 2.07e-01
CDC42 GTPase cycle 141 3.62e-03 0.142000 2.63e-02
HIV elongation arrest and recovery 32 1.66e-01 -0.142000 3.89e-01
Pausing and recovery of HIV elongation 32 1.66e-01 -0.142000 3.89e-01
Transport of fatty acids 5 5.84e-01 0.141000 7.76e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 3.59e-01 0.141000 6.00e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.22e-01 0.141000 4.55e-01
Association of TriC/CCT with target proteins during biosynthesis 35 1.49e-01 -0.141000 3.67e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 4.89e-02 -0.140000 1.81e-01
Regulation of TLR by endogenous ligand 15 3.48e-01 -0.140000 5.97e-01
Reversible hydration of carbon dioxide 8 4.94e-01 0.140000 7.09e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.72e-01 -0.139000 3.96e-01
Signaling by MAPK mutants 6 5.55e-01 -0.139000 7.57e-01
FGFR2 alternative splicing 25 2.29e-01 -0.139000 4.65e-01
Downstream signaling of activated FGFR4 18 3.08e-01 0.139000 5.59e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 3.37e-01 -0.139000 5.86e-01
Assembly of the pre-replicative complex 87 2.55e-02 -0.139000 1.17e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 5.92e-01 -0.139000 7.81e-01
Interleukin-7 signaling 21 2.73e-01 0.138000 5.20e-01
Lewis blood group biosynthesis 14 3.73e-01 -0.138000 6.11e-01
Signal transduction by L1 20 2.87e-01 0.138000 5.37e-01
Apoptotic factor-mediated response 19 3.00e-01 -0.137000 5.49e-01
Biosynthesis of EPA-derived SPMs 6 5.62e-01 0.137000 7.61e-01
Integration of energy metabolism 88 2.70e-02 0.136000 1.22e-01
Interleukin-1 signaling 99 1.90e-02 -0.136000 9.58e-02
Peptide ligand-binding receptors 101 1.80e-02 0.136000 9.26e-02
Formation of HIV elongation complex in the absence of HIV Tat 44 1.19e-01 -0.136000 3.23e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 2.39e-01 -0.136000 4.81e-01
Defective GALNT12 causes CRCS1 9 4.81e-01 0.136000 6.97e-01
Interleukin-12 signaling 44 1.20e-01 -0.135000 3.24e-01
Resolution of Sister Chromatid Cohesion 116 1.17e-02 0.135000 6.81e-02
Tryptophan catabolism 12 4.18e-01 -0.135000 6.45e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 2.96e-01 0.135000 5.46e-01
Trafficking of AMPA receptors 20 2.96e-01 0.135000 5.46e-01
Fanconi Anemia Pathway 36 1.62e-01 -0.135000 3.82e-01
Metabolism of folate and pterines 16 3.51e-01 -0.135000 5.98e-01
Deadenylation-dependent mRNA decay 50 9.93e-02 -0.135000 2.86e-01
Cilium Assembly 186 1.53e-03 -0.135000 1.32e-02
G beta:gamma signalling through BTK 15 3.67e-01 0.135000 6.05e-01
Sema4D mediated inhibition of cell attachment and migration 7 5.38e-01 0.135000 7.45e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.64e-01 -0.134000 5.11e-01
Glycine degradation 7 5.38e-01 -0.134000 7.45e-01
Antiviral mechanism by IFN-stimulated genes 140 6.11e-03 -0.134000 3.97e-02
Synthesis of PIPs at the early endosome membrane 16 3.53e-01 0.134000 5.98e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 4.22e-01 -0.134000 6.48e-01
Signaling by Hedgehog 120 1.13e-02 -0.134000 6.62e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 5.40e-01 -0.134000 7.46e-01
Acyl chain remodelling of PS 14 3.86e-01 -0.134000 6.20e-01
Signaling by FGFR3 in disease 14 3.87e-01 0.133000 6.20e-01
MECP2 regulates neuronal receptors and channels 14 3.90e-01 0.133000 6.23e-01
Phospholipase C-mediated cascade; FGFR3 5 6.10e-01 -0.132000 7.94e-01
G2/M Transition 177 2.49e-03 -0.132000 2.00e-02
Organelle biogenesis and maintenance 277 1.61e-04 -0.132000 1.92e-03
Signaling by BMP 23 2.75e-01 0.132000 5.21e-01
Thromboxane signalling through TP receptor 20 3.10e-01 0.131000 5.60e-01
TGF-beta receptor signaling activates SMADs 45 1.28e-01 0.131000 3.41e-01
RIPK1-mediated regulated necrosis 31 2.08e-01 -0.131000 4.38e-01
Regulation of necroptotic cell death 31 2.08e-01 -0.131000 4.38e-01
Interleukin-6 signaling 11 4.55e-01 0.130000 6.77e-01
RND3 GTPase cycle 36 1.76e-01 0.130000 4.00e-01
Formation of the Editosome 6 5.81e-01 0.130000 7.75e-01
mRNA Editing: C to U Conversion 6 5.81e-01 0.130000 7.75e-01
PI3K events in ERBB4 signaling 6 5.81e-01 0.130000 7.75e-01
S Phase 150 5.97e-03 -0.130000 3.95e-02
Activation of RAS in B cells 5 6.15e-01 -0.130000 7.96e-01
Post-chaperonin tubulin folding pathway 18 3.43e-01 0.129000 5.92e-01
RNA Polymerase III Chain Elongation 18 3.44e-01 -0.129000 5.93e-01
Meiotic synapsis 43 1.45e-01 0.128000 3.62e-01
Peroxisomal lipid metabolism 27 2.48e-01 -0.128000 4.91e-01
Keratinization 37 1.77e-01 0.128000 4.00e-01
Early SARS-CoV-2 Infection Events 31 2.16e-01 -0.128000 4.47e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 2.67e-01 0.128000 5.15e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.41e-01 -0.128000 4.83e-01
FGFR1b ligand binding and activation 5 6.21e-01 0.128000 7.98e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.47e-01 -0.128000 3.64e-01
Cellular hexose transport 14 4.10e-01 -0.127000 6.40e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 5.08e-01 0.127000 7.18e-01
AKT phosphorylates targets in the cytosol 14 4.10e-01 0.127000 6.40e-01
RND2 GTPase cycle 37 1.82e-01 0.127000 4.07e-01
Glycosphingolipid biosynthesis 15 3.95e-01 0.127000 6.26e-01
PI Metabolism 79 5.21e-02 0.126000 1.88e-01
MET activates PTK2 signaling 23 2.94e-01 0.126000 5.45e-01
Centrosome maturation 81 4.98e-02 -0.126000 1.82e-01
Recruitment of mitotic centrosome proteins and complexes 81 4.98e-02 -0.126000 1.82e-01
Incretin synthesis, secretion, and inactivation 14 4.15e-01 -0.126000 6.42e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 4.15e-01 -0.126000 6.42e-01
Downstream signal transduction 27 2.58e-01 0.126000 5.00e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 5.34e-02 0.126000 1.91e-01
O-linked glycosylation of mucins 47 1.36e-01 0.126000 3.48e-01
Signaling by ALK 24 2.87e-01 -0.126000 5.37e-01
Pre-NOTCH Processing in Golgi 18 3.57e-01 0.126000 5.99e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.61e-01 -0.125000 3.82e-01
MicroRNA (miRNA) biogenesis 24 2.89e-01 -0.125000 5.39e-01
Molecules associated with elastic fibres 26 2.71e-01 0.125000 5.19e-01
Extra-nuclear estrogen signaling 67 7.82e-02 0.124000 2.47e-01
SARS-CoV-2 Infection 267 4.65e-04 -0.124000 4.80e-03
Gastrin-CREB signalling pathway via PKC and MAPK 14 4.21e-01 0.124000 6.47e-01
SUMOylation of DNA damage response and repair proteins 77 5.97e-02 -0.124000 2.06e-01
Maturation of hRSV A proteins 13 4.39e-01 0.124000 6.64e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.56e-02 -0.124000 1.75e-01
Transmission across Chemical Synapses 188 3.44e-03 0.124000 2.61e-02
Potential therapeutics for SARS 149 9.19e-03 0.124000 5.50e-02
Signaling by FGFR3 32 2.27e-01 0.123000 4.62e-01
RHO GTPases Activate WASPs and WAVEs 35 2.06e-01 0.123000 4.37e-01
Mitochondrial biogenesis 91 4.17e-02 -0.123000 1.65e-01
Myogenesis 21 3.27e-01 0.123000 5.76e-01
DNA Replication 128 1.59e-02 -0.123000 8.46e-02
Nef mediated downregulation of MHC class I complex cell surface expression 10 4.99e-01 0.123000 7.13e-01
TP53 Regulates Transcription of DNA Repair Genes 61 9.63e-02 -0.123000 2.80e-01
NR1H2 and NR1H3-mediated signaling 39 1.84e-01 -0.123000 4.09e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 9.45e-02 0.123000 2.77e-01
EML4 and NUDC in mitotic spindle formation 107 2.84e-02 0.123000 1.26e-01
Eicosanoids 6 6.03e-01 0.122000 7.90e-01
Hydrolysis of LPC 8 5.49e-01 0.122000 7.54e-01
Activation of BH3-only proteins 30 2.46e-01 0.122000 4.89e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 6.05e-01 0.122000 7.90e-01
Sulfur amino acid metabolism 23 3.12e-01 -0.122000 5.62e-01
Type I hemidesmosome assembly 8 5.52e-01 -0.122000 7.54e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 6.07e-01 0.121000 7.92e-01
TGFBR1 KD Mutants in Cancer 6 6.07e-01 0.121000 7.92e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.25e-01 0.121000 5.74e-01
Signaling by the B Cell Receptor (BCR) 150 1.05e-02 0.121000 6.18e-02
Phase 4 - resting membrane potential 9 5.30e-01 -0.121000 7.38e-01
SUMOylation of chromatin organization proteins 57 1.14e-01 -0.121000 3.16e-01
Transcription of the HIV genome 67 8.71e-02 -0.121000 2.62e-01
Mitotic G2-G2/M phases 179 5.39e-03 -0.121000 3.64e-02
SHC-related events triggered by IGF1R 8 5.56e-01 0.120000 7.57e-01
Toxicity of botulinum toxin type D (botD) 5 6.41e-01 -0.120000 8.09e-01
Toxicity of botulinum toxin type F (botF) 5 6.41e-01 -0.120000 8.09e-01
Recycling of bile acids and salts 10 5.10e-01 -0.120000 7.20e-01
Signaling by NTRK2 (TRKB) 20 3.53e-01 0.120000 5.98e-01
ABC transporters in lipid homeostasis 14 4.37e-01 -0.120000 6.62e-01
Transcriptional regulation by RUNX3 81 6.19e-02 -0.120000 2.08e-01
Cell recruitment (pro-inflammatory response) 25 3.00e-01 -0.120000 5.49e-01
Purinergic signaling in leishmaniasis infection 25 3.00e-01 -0.120000 5.49e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.42e-01 -0.120000 5.91e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.42e-01 -0.120000 5.91e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.54e-01 -0.120000 5.98e-01
Biosynthesis of maresins 7 5.84e-01 -0.119000 7.76e-01
RAB GEFs exchange GTP for GDP on RABs 89 5.21e-02 0.119000 1.88e-01
NrCAM interactions 6 6.14e-01 -0.119000 7.96e-01
Nuclear Receptor transcription pathway 40 1.93e-01 -0.119000 4.20e-01
Transcriptional regulation by RUNX2 92 4.90e-02 -0.119000 1.81e-01
FGFR2b ligand binding and activation 6 6.15e-01 0.119000 7.96e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 5.38e-01 0.119000 7.45e-01
Interleukin-23 signaling 7 5.89e-01 -0.118000 7.79e-01
Fatty acyl-CoA biosynthesis 35 2.27e-01 0.118000 4.62e-01
FGFR1 ligand binding and activation 10 5.18e-01 0.118000 7.28e-01
RHOA GTPase cycle 139 1.65e-02 0.118000 8.63e-02
Activation of NOXA and translocation to mitochondria 5 6.48e-01 -0.118000 8.11e-01
Mitotic Telophase/Cytokinesis 13 4.63e-01 0.118000 6.84e-01
Ca2+ pathway 58 1.21e-01 0.118000 3.28e-01
Vesicle-mediated transport 669 2.19e-07 0.117000 5.28e-06
Paracetamol ADME 19 3.77e-01 -0.117000 6.15e-01
DNA Replication Pre-Initiation 103 4.04e-02 -0.117000 1.63e-01
RET signaling 32 2.53e-01 0.117000 4.95e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.55e-01 -0.117000 5.98e-01
IRAK2 mediated activation of TAK1 complex 10 5.23e-01 -0.117000 7.31e-01
RHOBTB1 GTPase cycle 23 3.34e-01 -0.116000 5.83e-01
Transport and synthesis of PAPS 6 6.23e-01 0.116000 8.00e-01
Regulation of PTEN mRNA translation 13 4.69e-01 0.116000 6.89e-01
DNA replication initiation 8 5.71e-01 -0.116000 7.69e-01
Cellular responses to mechanical stimuli 82 7.00e-02 0.116000 2.29e-01
Response of endothelial cells to shear stress 82 7.00e-02 0.116000 2.29e-01
APC-Cdc20 mediated degradation of Nek2A 26 3.07e-01 -0.116000 5.59e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 3.85e-01 0.115000 6.20e-01
Platelet sensitization by LDL 16 4.26e-01 0.115000 6.52e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 6.26e-01 0.115000 8.03e-01
Apoptosis induced DNA fragmentation 10 5.30e-01 0.115000 7.38e-01
Signaling by BRAF and RAF1 fusions 60 1.25e-01 0.114000 3.34e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 3.33e-02 0.114000 1.41e-01
Gastrulation 76 8.60e-02 -0.114000 2.61e-01
Negative regulation of FGFR3 signaling 21 3.66e-01 0.114000 6.05e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 6.05e-02 0.114000 2.06e-01
Amplification of signal from the kinetochores 91 6.05e-02 0.114000 2.06e-01
Respiratory Syncytial Virus Infection Pathway 99 5.05e-02 -0.114000 1.83e-01
Nectin/Necl trans heterodimerization 5 6.60e-01 0.114000 8.20e-01
Activated point mutants of FGFR2 7 6.03e-01 -0.114000 7.90e-01
Regulation of NFE2L2 gene expression 8 5.78e-01 0.113000 7.74e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 4.18e-01 -0.113000 6.45e-01
Downstream signaling of activated FGFR2 20 3.81e-01 0.113000 6.18e-01
Senescence-Associated Secretory Phenotype (SASP) 65 1.15e-01 0.113000 3.16e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 2.11e-01 0.113000 4.38e-01
RHOBTB GTPase Cycle 35 2.49e-01 -0.113000 4.92e-01
FGFR4 ligand binding and activation 5 6.63e-01 -0.113000 8.22e-01
Acyl chain remodelling of PI 10 5.38e-01 0.112000 7.45e-01
Signaling by ERBB2 ECD mutants 15 4.54e-01 0.112000 6.77e-01
Drug ADME 59 1.38e-01 -0.112000 3.51e-01
O-glycosylation of TSR domain-containing proteins 28 3.07e-01 0.111000 5.59e-01
IKK complex recruitment mediated by RIP1 23 3.56e-01 -0.111000 5.99e-01
Viral Infection Pathways 776 1.36e-07 -0.111000 3.42e-06
Signaling by SCF-KIT 40 2.24e-01 0.111000 4.57e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 1.00e-01 -0.111000 2.87e-01
Chemokine receptors bind chemokines 39 2.32e-01 0.111000 4.71e-01
L1CAM interactions 100 5.63e-02 0.110000 1.98e-01
Signaling by high-kinase activity BRAF mutants 33 2.72e-01 0.110000 5.19e-01
RUNX2 regulates genes involved in cell migration 6 6.40e-01 0.110000 8.09e-01
RAC3 GTPase cycle 88 7.43e-02 0.110000 2.39e-01
Signaling by FLT3 fusion proteins 18 4.19e-01 -0.110000 6.45e-01
VEGFR2 mediated vascular permeability 26 3.32e-01 -0.110000 5.82e-01
Synthesis of bile acids and bile salts 27 3.24e-01 0.110000 5.73e-01
Metabolic disorders of biological oxidation enzymes 26 3.33e-01 0.110000 5.83e-01
Rap1 signalling 14 4.78e-01 0.110000 6.94e-01
Fatty acids 6 6.42e-01 -0.109000 8.09e-01
Kinesins 51 1.77e-01 0.109000 4.00e-01
Signaling by TGFB family members 139 2.62e-02 0.109000 1.19e-01
NRIF signals cell death from the nucleus 15 4.65e-01 0.109000 6.85e-01
SUMOylation of DNA replication proteins 46 2.01e-01 -0.109000 4.32e-01
Arachidonate metabolism 45 2.07e-01 0.109000 4.38e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.99e-01 0.108000 7.13e-01
Retinoid metabolism and transport 25 3.48e-01 0.108000 5.97e-01
Neurexins and neuroligins 40 2.36e-01 -0.108000 4.75e-01
AKT phosphorylates targets in the nucleus 9 5.75e-01 -0.108000 7.71e-01
Signaling by RAF1 mutants 37 2.55e-01 0.108000 4.97e-01
Diseases of branched-chain amino acid catabolism 13 5.00e-01 -0.108000 7.13e-01
Gap junction assembly 17 4.43e-01 0.107000 6.67e-01
Collagen chain trimerization 29 3.18e-01 0.107000 5.67e-01
Prevention of phagosomal-lysosomal fusion 9 5.80e-01 -0.107000 7.75e-01
Triglyceride catabolism 16 4.60e-01 0.107000 6.83e-01
Pyrimidine catabolism 9 5.80e-01 0.107000 7.75e-01
Purine catabolism 16 4.61e-01 -0.106000 6.83e-01
Synthesis of PIPs at the ER membrane 5 6.81e-01 0.106000 8.31e-01
Transcriptional Regulation by NPAS4 27 3.40e-01 0.106000 5.89e-01
SMAC (DIABLO) binds to IAPs 7 6.27e-01 -0.106000 8.03e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 6.27e-01 -0.106000 8.03e-01
SMAC, XIAP-regulated apoptotic response 7 6.27e-01 -0.106000 8.03e-01
Integrin cell surface interactions 68 1.31e-01 0.106000 3.42e-01
Cellular responses to stress 698 1.94e-06 -0.106000 4.02e-05
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 3.83e-01 0.105000 6.20e-01
Translation of Structural Proteins 9694635 56 1.74e-01 0.105000 3.98e-01
Interleukin-2 signaling 11 5.47e-01 -0.105000 7.53e-01
RHO GTPases activate CIT 18 4.42e-01 0.105000 6.66e-01
Signaling by FGFR4 32 3.07e-01 0.104000 5.59e-01
Inactivation of CSF3 (G-CSF) signaling 24 3.77e-01 -0.104000 6.15e-01
Gap junction trafficking 28 3.41e-01 0.104000 5.91e-01
Adenylate cyclase activating pathway 8 6.11e-01 0.104000 7.95e-01
Cation-coupled Chloride cotransporters 6 6.60e-01 -0.104000 8.20e-01
EPH-Ephrin signaling 81 1.06e-01 0.104000 3.02e-01
Defective B3GALTL causes PpS 27 3.53e-01 0.103000 5.98e-01
Killing mechanisms 9 5.92e-01 -0.103000 7.81e-01
WNT5:FZD7-mediated leishmania damping 9 5.92e-01 -0.103000 7.81e-01
Phospholipid metabolism 183 1.62e-02 0.103000 8.55e-02
Regulation of pyruvate dehydrogenase (PDH) complex 14 5.05e-01 -0.103000 7.15e-01
Late SARS-CoV-2 Infection Events 64 1.56e-01 0.103000 3.77e-01
RNA Polymerase III Transcription Initiation 36 2.90e-01 -0.102000 5.39e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 4.70e-01 0.101000 6.90e-01
NGF-stimulated transcription 32 3.22e-01 -0.101000 5.71e-01
Signaling by RNF43 mutants 7 6.43e-01 0.101000 8.09e-01
Lipophagy 7 6.44e-01 0.101000 8.09e-01
Spry regulation of FGF signaling 16 4.84e-01 0.101000 6.99e-01
Factors involved in megakaryocyte development and platelet production 129 4.84e-02 0.101000 1.81e-01
RNA polymerase II transcribes snRNA genes 71 1.43e-01 -0.101000 3.58e-01
FRS-mediated FGFR4 signaling 13 5.30e-01 0.101000 7.38e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 6.71e-01 0.100000 8.27e-01
Glycogen metabolism 21 4.29e-01 0.099800 6.55e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 4.40e-01 -0.099700 6.65e-01
Oxidative Stress Induced Senescence 77 1.31e-01 0.099600 3.42e-01
P2Y receptors 10 5.86e-01 -0.099600 7.77e-01
Dissolution of Fibrin Clot 12 5.51e-01 -0.099400 7.54e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 2.15e-01 -0.099300 4.45e-01
G2/M DNA damage checkpoint 66 1.63e-01 0.099300 3.84e-01
Loss of Nlp from mitotic centrosomes 69 1.54e-01 -0.099200 3.75e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 1.54e-01 -0.099200 3.75e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 5.88e-01 -0.099000 7.79e-01
Synthesis of substrates in N-glycan biosythesis 59 1.88e-01 -0.099000 4.13e-01
Negative regulation of FLT3 15 5.08e-01 -0.098800 7.17e-01
IRF3-mediated induction of type I IFN 12 5.55e-01 -0.098500 7.57e-01
Linoleic acid (LA) metabolism 7 6.52e-01 -0.098500 8.14e-01
N-glycan trimming and elongation in the cis-Golgi 5 7.03e-01 0.098300 8.43e-01
tRNA processing 128 5.48e-02 -0.098300 1.95e-01
Gap junction degradation 11 5.73e-01 0.098200 7.71e-01
Erythropoietin activates STAT5 6 6.77e-01 -0.098200 8.30e-01
B-WICH complex positively regulates rRNA expression 45 2.55e-01 0.098000 4.97e-01
Transport to the Golgi and subsequent modification 171 2.71e-02 0.098000 1.22e-01
Metabolism of cofactors 25 3.97e-01 -0.097800 6.27e-01
Fructose catabolism 5 7.05e-01 -0.097800 8.44e-01
G alpha (q) signalling events 139 4.68e-02 0.097700 1.78e-01
G alpha (i) signalling events 194 1.90e-02 0.097600 9.58e-02
DNA Repair 289 4.38e-03 -0.097400 3.04e-02
TNF signaling 56 2.09e-01 -0.097100 4.38e-01
Regulation of insulin secretion 63 1.83e-01 0.097100 4.07e-01
Initiation of Nuclear Envelope (NE) Reformation 19 4.64e-01 0.097100 6.84e-01
G1/S Transition 120 6.65e-02 -0.097000 2.21e-01
PERK regulates gene expression 30 3.58e-01 -0.096900 6.00e-01
ERBB2 Regulates Cell Motility 10 5.98e-01 0.096400 7.85e-01
Infection with Mycobacterium tuberculosis 26 3.95e-01 0.096300 6.26e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 1.67e-01 -0.096300 3.89e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 6.60e-01 -0.096100 8.20e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 4.81e-01 -0.096000 6.97e-01
Pentose phosphate pathway 13 5.50e-01 0.095800 7.54e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 4.71e-01 0.095600 6.90e-01
Degradation of cysteine and homocysteine 13 5.51e-01 -0.095400 7.54e-01
Clathrin-mediated endocytosis 128 6.26e-02 0.095300 2.09e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 4.10e-01 0.095300 6.40e-01
Phospholipase C-mediated cascade: FGFR1 8 6.42e-01 0.094800 8.09e-01
Disorders of transmembrane transporters 137 5.60e-02 -0.094500 1.98e-01
Intra-Golgi traffic 43 2.83e-01 0.094500 5.32e-01
Activation of HOX genes during differentiation 70 1.72e-01 0.094400 3.96e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 1.72e-01 0.094400 3.96e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 5.64e-05 0.094400 7.90e-04
Blood group systems biosynthesis 18 4.88e-01 -0.094300 7.02e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 5.16e-01 0.093800 7.26e-01
Glutathione conjugation 28 3.91e-01 -0.093600 6.24e-01
Regulation of NF-kappa B signaling 18 4.92e-01 -0.093600 7.07e-01
RMTs methylate histone arginines 35 3.38e-01 -0.093500 5.87e-01
Processing and activation of SUMO 10 6.09e-01 -0.093400 7.93e-01
Meiosis 67 1.86e-01 0.093400 4.10e-01
Signaling by FGFR2 in disease 33 3.53e-01 -0.093300 5.98e-01
Elastic fibre formation 33 3.54e-01 0.093200 5.98e-01
Gap junction trafficking and regulation 30 3.78e-01 0.093100 6.16e-01
Glutamate and glutamine metabolism 12 5.77e-01 0.092900 7.73e-01
Termination of O-glycan biosynthesis 16 5.20e-01 0.092900 7.29e-01
Growth hormone receptor signaling 21 4.61e-01 0.092900 6.83e-01
Diseases associated with N-glycosylation of proteins 20 4.72e-01 -0.092800 6.90e-01
Signaling by cytosolic FGFR1 fusion mutants 18 4.96e-01 0.092700 7.10e-01
trans-Golgi Network Vesicle Budding 69 1.84e-01 0.092600 4.08e-01
Metabolism of fat-soluble vitamins 28 3.97e-01 0.092400 6.27e-01
Dopamine Neurotransmitter Release Cycle 20 4.77e-01 -0.091800 6.94e-01
Sodium-coupled phosphate cotransporters 5 7.22e-01 0.091700 8.52e-01
Prostacyclin signalling through prostacyclin receptor 16 5.25e-01 0.091700 7.33e-01
O-linked glycosylation 85 1.47e-01 0.091000 3.64e-01
VEGFA-VEGFR2 Pathway 93 1.29e-01 0.091000 3.42e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 7.25e-01 0.091000 8.53e-01
Josephin domain DUBs 10 6.19e-01 -0.090900 7.98e-01
PI3K/AKT Signaling in Cancer 85 1.48e-01 0.090800 3.65e-01
Ca2+ activated K+ channels 6 7.01e-01 0.090400 8.43e-01
LGI-ADAM interactions 9 6.39e-01 -0.090300 8.09e-01
WNT ligand biogenesis and trafficking 19 4.96e-01 -0.090200 7.10e-01
Nuclear Pore Complex (NPC) Disassembly 36 3.51e-01 -0.089900 5.98e-01
Signaling by Rho GTPases 608 1.55e-04 0.089800 1.87e-03
RUNX3 Regulates Immune Response and Cell Migration 6 7.04e-01 0.089600 8.43e-01
TGFBR3 regulates TGF-beta signaling 8 6.61e-01 -0.089600 8.21e-01
SUMO E3 ligases SUMOylate target proteins 161 5.00e-02 -0.089500 1.82e-01
Glyoxylate metabolism and glycine degradation 13 5.77e-01 -0.089300 7.73e-01
Metal ion SLC transporters 19 5.01e-01 0.089200 7.13e-01
Glutamate Neurotransmitter Release Cycle 20 4.91e-01 -0.089000 7.06e-01
IRAK4 deficiency (TLR2/4) 15 5.51e-01 0.088900 7.54e-01
The phototransduction cascade 26 4.34e-01 0.088600 6.58e-01
Zygotic genome activation (ZGA) 5 7.32e-01 0.088500 8.60e-01
RAF-independent MAPK1/3 activation 22 4.73e-01 0.088300 6.91e-01
Innate Immune System 971 3.16e-06 0.088300 6.23e-05
Rab regulation of trafficking 122 9.22e-02 0.088300 2.72e-01
Regulation of TNFR1 signaling 47 2.95e-01 -0.088200 5.46e-01
PDH complex synthesizes acetyl-CoA from PYR 5 7.34e-01 -0.087900 8.62e-01
Plasma lipoprotein clearance 33 3.84e-01 -0.087600 6.20e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 4.31e-01 0.087600 6.57e-01
Metabolism 1835 5.16e-10 -0.087400 1.51e-08
FGFR1c ligand binding and activation 8 6.70e-01 0.086900 8.27e-01
Glycerophospholipid biosynthesis 105 1.25e-01 0.086700 3.33e-01
Defective LFNG causes SCDO3 5 7.37e-01 -0.086600 8.64e-01
E2F mediated regulation of DNA replication 22 4.83e-01 0.086400 6.98e-01
G-protein activation 19 5.14e-01 0.086400 7.25e-01
Vitamin B1 (thiamin) metabolism 5 7.38e-01 0.086200 8.64e-01
HDMs demethylate histones 22 4.84e-01 0.086100 6.99e-01
Activated NTRK3 signals through RAS 7 6.95e-01 0.085600 8.40e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.10e-01 0.085500 6.40e-01
Nonhomologous End-Joining (NHEJ) 40 3.49e-01 0.085500 5.98e-01
Metabolism of proteins 1777 2.14e-09 -0.085500 5.99e-08
GPVI-mediated activation cascade 33 3.97e-01 0.085200 6.27e-01
Post-translational modification: synthesis of GPI-anchored proteins 59 2.58e-01 -0.085100 5.00e-01
SUMOylation 167 5.82e-02 -0.085000 2.04e-01
Induction of Cell-Cell Fusion 8 6.78e-01 0.084700 8.30e-01
RAC2 GTPase cycle 86 1.75e-01 0.084600 3.99e-01
Telomere Maintenance 78 1.97e-01 -0.084400 4.27e-01
RHO GTPases Activate Formins 128 9.97e-02 0.084300 2.87e-01
RORA activates gene expression 18 5.38e-01 0.083900 7.45e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 1.32e-01 -0.083800 3.42e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 5.39e-01 -0.083700 7.45e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 5.90e-01 -0.083300 7.80e-01
Activation of RAC1 downstream of NMDARs 7 7.03e-01 0.083100 8.43e-01
Iron uptake and transport 52 3.00e-01 -0.083100 5.49e-01
Anchoring of the basal body to the plasma membrane 97 1.60e-01 -0.082500 3.82e-01
cGMP effects 12 6.21e-01 0.082500 7.98e-01
ESR-mediated signaling 160 7.20e-02 0.082400 2.33e-01
Neuronal System 276 1.86e-02 0.082300 9.41e-02
Transcriptional Regulation by E2F6 34 4.06e-01 0.082300 6.36e-01
Cargo concentration in the ER 31 4.28e-01 0.082200 6.55e-01
Signaling by FGFR1 42 3.57e-01 0.082200 5.99e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 4.78e-01 0.082000 6.94e-01
Diseases associated with glycosylation precursor biosynthesis 15 5.84e-01 -0.081600 7.76e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 3.66e-01 0.081600 6.05e-01
Signaling by RAS mutants 41 3.66e-01 0.081600 6.05e-01
Signaling by moderate kinase activity BRAF mutants 41 3.66e-01 0.081600 6.05e-01
Signaling downstream of RAS mutants 41 3.66e-01 0.081600 6.05e-01
Endogenous sterols 18 5.50e-01 -0.081400 7.54e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 2.06e-01 0.081300 4.37e-01
Bile acid and bile salt metabolism 31 4.34e-01 0.081200 6.58e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 5.40e-01 -0.081200 7.46e-01
RHO GTPases Activate NADPH Oxidases 21 5.21e-01 0.081000 7.29e-01
Signaling by Receptor Tyrosine Kinases 449 3.28e-03 0.080900 2.53e-02
RAC1 GTPase cycle 173 6.64e-02 0.080900 2.21e-01
Metabolism of water-soluble vitamins and cofactors 115 1.34e-01 -0.080800 3.46e-01
activated TAK1 mediates p38 MAPK activation 23 5.03e-01 0.080800 7.13e-01
Signaling by ERBB2 in Cancer 21 5.22e-01 0.080700 7.29e-01
TAK1-dependent IKK and NF-kappa-B activation 43 3.61e-01 -0.080600 6.01e-01
Regulation of gene expression in beta cells 8 6.95e-01 0.080100 8.40e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 6.95e-01 0.080100 8.40e-01
Synthesis of very long-chain fatty acyl-CoAs 22 5.16e-01 0.080000 7.26e-01
Constitutive Signaling by Overexpressed ERBB2 11 6.46e-01 0.080000 8.10e-01
CLEC7A (Dectin-1) induces NFAT activation 11 6.47e-01 0.079800 8.10e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 5.00e-01 0.079500 7.13e-01
Signaling by NTRK3 (TRKC) 16 5.82e-01 -0.079400 7.76e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 3.09e-01 0.079400 5.59e-01
Aspirin ADME 16 5.83e-01 0.079300 7.76e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.50e-01 0.079200 7.54e-01
Reversal of alkylation damage by DNA dioxygenases 7 7.17e-01 0.079100 8.48e-01
Cholesterol biosynthesis 26 4.85e-01 -0.079100 6.99e-01
Constitutive Signaling by Aberrant PI3K in Cancer 59 2.94e-01 0.079000 5.45e-01
Diseases of mitotic cell cycle 38 4.00e-01 -0.078800 6.30e-01
Interleukin-4 and Interleukin-13 signaling 93 1.89e-01 0.078800 4.13e-01
Synthesis of PG 8 7.00e-01 -0.078800 8.43e-01
G beta:gamma signalling through CDC42 17 5.74e-01 0.078800 7.71e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 5.05e-01 -0.078700 7.15e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 5.05e-01 -0.078700 7.15e-01
Metabolism of Angiotensinogen to Angiotensins 12 6.38e-01 0.078500 8.09e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 3.57e-01 -0.078500 6.00e-01
TBC/RABGAPs 45 3.64e-01 0.078100 6.04e-01
FGFR2c ligand binding and activation 5 7.62e-01 -0.078100 8.77e-01
Carboxyterminal post-translational modifications of tubulin 34 4.32e-01 0.077900 6.57e-01
Cellular responses to stimuli 779 2.17e-04 -0.077900 2.49e-03
Interleukin-12 family signaling 53 3.29e-01 -0.077500 5.78e-01
Fatty acid metabolism 155 9.64e-02 -0.077400 2.80e-01
Activation of NMDA receptors and postsynaptic events 74 2.51e-01 0.077200 4.94e-01
PI5P Regulates TP53 Acetylation 8 7.06e-01 -0.076900 8.44e-01
Branched-chain amino acid catabolism 21 5.42e-01 -0.076900 7.47e-01
ER Quality Control Compartment (ERQC) 21 5.42e-01 0.076900 7.47e-01
Synthesis of Ketone Bodies 6 7.44e-01 -0.076900 8.66e-01
Regulation of FZD by ubiquitination 16 5.97e-01 -0.076400 7.85e-01
Formation of annular gap junctions 10 6.76e-01 0.076300 8.30e-01
Intrinsic Pathway for Apoptosis 54 3.34e-01 0.076100 5.83e-01
TRAF3-dependent IRF activation pathway 13 6.35e-01 -0.076000 8.08e-01
Synthesis of PIPs at the Golgi membrane 16 6.00e-01 0.075800 7.87e-01
Transcriptional Regulation by MECP2 49 3.59e-01 0.075700 6.00e-01
Cardiogenesis 16 6.00e-01 -0.075700 7.87e-01
Visual phototransduction 60 3.11e-01 0.075600 5.60e-01
Insulin processing 19 5.69e-01 0.075500 7.67e-01
Oncogene Induced Senescence 33 4.54e-01 0.075300 6.77e-01
SLC-mediated transmembrane transport 175 8.67e-02 0.075100 2.61e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.00e-01 0.074900 7.13e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 6.82e-01 -0.074900 8.31e-01
Signaling by FGFR4 in disease 11 6.67e-01 0.074800 8.25e-01
Sensory Perception 197 7.02e-02 0.074800 2.29e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 3.61e-01 0.074600 6.01e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.95e-01 0.074500 7.84e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.95e-01 0.074500 7.84e-01
Inhibition of DNA recombination at telomere 33 4.61e-01 0.074100 6.83e-01
Sialic acid metabolism 28 4.99e-01 -0.073900 7.13e-01
Post-translational protein phosphorylation 70 2.86e-01 0.073800 5.35e-01
MAP kinase activation 63 3.11e-01 0.073800 5.60e-01
LDL clearance 18 5.88e-01 0.073700 7.79e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 5.01e-01 -0.073500 7.13e-01
Golgi-to-ER retrograde transport 123 1.60e-01 0.073400 3.82e-01
Heme signaling 45 3.95e-01 0.073400 6.26e-01
Constitutive Signaling by EGFRvIII 14 6.36e-01 0.073100 8.08e-01
Signaling by EGFRvIII in Cancer 14 6.36e-01 0.073100 8.08e-01
Signaling by Non-Receptor Tyrosine Kinases 47 3.86e-01 0.073100 6.20e-01
Signaling by PTK6 47 3.86e-01 0.073100 6.20e-01
ADP signalling through P2Y purinoceptor 1 21 5.63e-01 0.072900 7.62e-01
Oncogenic MAPK signaling 76 2.72e-01 0.072900 5.19e-01
EPHA-mediated growth cone collapse 21 5.64e-01 0.072800 7.62e-01
mRNA Editing 8 7.23e-01 -0.072400 8.52e-01
Negative regulation of FGFR4 signaling 22 5.58e-01 0.072200 7.57e-01
Signaling by LTK 10 6.93e-01 0.072000 8.40e-01
SUMOylation of ubiquitinylation proteins 39 4.37e-01 -0.071900 6.62e-01
Signaling by ERBB2 44 4.11e-01 0.071600 6.41e-01
FRS-mediated FGFR2 signaling 15 6.31e-01 0.071600 8.06e-01
NCAM1 interactions 27 5.20e-01 -0.071500 7.29e-01
Collagen biosynthesis and modifying enzymes 48 3.91e-01 0.071500 6.24e-01
Programmed Cell Death 187 9.23e-02 -0.071400 2.72e-01
Diseases of carbohydrate metabolism 29 5.06e-01 0.071400 7.16e-01
RHO GTPases activate KTN1 11 6.83e-01 -0.071200 8.31e-01
RHOH GTPase cycle 34 4.73e-01 0.071200 6.90e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.32e-01 -0.070900 6.57e-01
RNA Polymerase III Transcription 41 4.32e-01 -0.070900 6.57e-01
Signaling by TGFBR3 39 4.44e-01 0.070900 6.67e-01
AURKA Activation by TPX2 72 2.99e-01 -0.070900 5.49e-01
Nervous system development 478 7.98e-03 -0.070800 4.86e-02
Scavenging by Class A Receptors 14 6.47e-01 -0.070800 8.10e-01
MyD88 deficiency (TLR2/4) 14 6.49e-01 0.070300 8.11e-01
Nuclear events mediated by NFE2L2 82 2.74e-01 -0.069900 5.20e-01
ROBO receptors bind AKAP5 7 7.49e-01 -0.069900 8.69e-01
Transcriptional regulation by RUNX1 170 1.17e-01 0.069600 3.21e-01
Nef Mediated CD4 Down-regulation 9 7.19e-01 -0.069300 8.49e-01
Recruitment of NuMA to mitotic centrosomes 88 2.62e-01 -0.069100 5.08e-01
Axon guidance 459 1.13e-02 -0.069000 6.60e-02
COPI-mediated anterograde transport 92 2.55e-01 0.068700 4.97e-01
Mitotic G1 phase and G1/S transition 138 1.64e-01 -0.068700 3.86e-01
Reproduction 85 2.74e-01 0.068700 5.20e-01
Membrane Trafficking 577 4.93e-03 0.068500 3.38e-02
Deactivation of the beta-catenin transactivating complex 36 4.77e-01 -0.068400 6.94e-01
Plasma lipoprotein assembly 10 7.08e-01 0.068400 8.44e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 6.70e-01 0.068300 8.26e-01
MAP2K and MAPK activation 36 4.78e-01 0.068300 6.94e-01
Potassium Channels 64 3.45e-01 0.068300 5.94e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 4.33e-01 0.068200 6.58e-01
Synthesis of GDP-mannose 6 7.73e-01 -0.068100 8.83e-01
Nuclear Events (kinase and transcription factor activation) 54 3.87e-01 -0.068100 6.20e-01
RNA Polymerase I Promoter Escape 45 4.31e-01 0.067900 6.57e-01
RNA Polymerase III Transcription Termination 23 5.74e-01 -0.067700 7.71e-01
Cytokine Signaling in Immune system 670 2.88e-03 -0.067500 2.26e-02
Phase I - Functionalization of compounds 70 3.29e-01 -0.067400 5.78e-01
Cargo recognition for clathrin-mediated endocytosis 89 2.74e-01 0.067100 5.20e-01
IRE1alpha activates chaperones 46 4.32e-01 0.067000 6.57e-01
Signaling by ERBB2 TMD/JMD mutants 17 6.32e-01 -0.067000 8.07e-01
Methylation 13 6.78e-01 -0.066500 8.30e-01
Regulation of CDH11 mRNA translation by microRNAs 8 7.45e-01 -0.066500 8.66e-01
Regulation of NPAS4 mRNA translation 8 7.45e-01 -0.066500 8.66e-01
Receptor Mediated Mitophagy 11 7.03e-01 0.066400 8.43e-01
HS-GAG degradation 19 6.16e-01 0.066400 7.97e-01
Interleukin-17 signaling 68 3.45e-01 0.066200 5.94e-01
Nef and signal transduction 8 7.47e-01 -0.065900 8.67e-01
Signaling by VEGF 100 2.57e-01 0.065700 4.99e-01
Beta-oxidation of very long chain fatty acids 11 7.08e-01 0.065200 8.44e-01
G beta:gamma signalling through PLC beta 17 6.42e-01 0.065200 8.09e-01
Presynaptic function of Kainate receptors 17 6.42e-01 0.065200 8.09e-01
Regulation of BACH1 activity 11 7.08e-01 -0.065200 8.44e-01
Post-transcriptional silencing by small RNAs 7 7.66e-01 0.064900 8.78e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 7.11e-01 0.064600 8.45e-01
PKR-mediated signaling 67 3.61e-01 -0.064500 6.01e-01
Regulation of RUNX1 Expression and Activity 18 6.37e-01 0.064300 8.08e-01
CaM pathway 28 5.57e-01 0.064100 7.57e-01
Calmodulin induced events 28 5.57e-01 0.064100 7.57e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 5.65e-01 -0.064000 7.63e-01
Synaptic adhesion-like molecules 17 6.48e-01 -0.063900 8.11e-01
Neddylation 215 1.08e-01 -0.063600 3.04e-01
Signaling by EGFR in Cancer 23 5.99e-01 0.063400 7.87e-01
ER to Golgi Anterograde Transport 145 1.89e-01 0.063200 4.13e-01
Beta-catenin independent WNT signaling 126 2.22e-01 -0.063000 4.55e-01
FLT3 signaling in disease 27 5.72e-01 -0.062900 7.70e-01
Cyclin D associated events in G1 47 4.56e-01 -0.062900 6.78e-01
G1 Phase 47 4.56e-01 -0.062900 6.78e-01
Signaling by MST1 5 8.08e-01 -0.062900 9.08e-01
Protein-protein interactions at synapses 61 3.96e-01 -0.062800 6.27e-01
Post NMDA receptor activation events 64 3.85e-01 0.062800 6.20e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 7.74e-01 -0.062800 8.83e-01
Ca-dependent events 30 5.57e-01 0.062000 7.57e-01
Infectious disease 959 1.25e-03 -0.061500 1.12e-02
Class A/1 (Rhodopsin-like receptors) 175 1.61e-01 0.061400 3.82e-01
HATs acetylate histones 92 3.10e-01 0.061200 5.60e-01
Diseases of Mismatch Repair (MMR) 5 8.13e-01 0.061000 9.13e-01
GPCR downstream signalling 398 3.69e-02 0.060900 1.53e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 7.66e-01 -0.060700 8.78e-01
Activated NTRK2 signals through RAS 6 7.97e-01 0.060500 9.01e-01
Signal Transduction 2058 5.96e-06 0.060500 1.08e-04
Death Receptor Signaling 145 2.09e-01 -0.060400 4.38e-01
RAS processing 23 6.16e-01 0.060400 7.96e-01
SHC-mediated cascade:FGFR3 10 7.41e-01 0.060400 8.65e-01
Nicotinamide salvaging 15 6.86e-01 0.060200 8.33e-01
Vitamin C (ascorbate) metabolism 8 7.68e-01 0.060200 8.79e-01
Thyroxine biosynthesis 5 8.16e-01 -0.060200 9.15e-01
Maturation of protein 3a 9683673 9 7.55e-01 -0.060100 8.72e-01
Maturation of protein 3a 9694719 9 7.55e-01 -0.060100 8.72e-01
FLT3 Signaling 38 5.22e-01 0.060100 7.29e-01
Mitotic Spindle Checkpoint 108 2.82e-01 0.059900 5.31e-01
Signaling by Erythropoietin 24 6.13e-01 0.059700 7.96e-01
Glucose metabolism 76 3.70e-01 -0.059500 6.07e-01
Wax and plasmalogen biosynthesis 5 8.19e-01 0.059200 9.15e-01
Autophagy 142 2.23e-01 -0.059200 4.56e-01
CD28 co-stimulation 33 5.58e-01 -0.059000 7.57e-01
Elevation of cytosolic Ca2+ levels 13 7.13e-01 0.058800 8.47e-01
Activation of RAC1 11 7.36e-01 0.058700 8.64e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 5.85e-01 0.058600 7.77e-01
Transcriptional regulation of testis differentiation 5 8.21e-01 0.058300 9.17e-01
ERKs are inactivated 13 7.17e-01 -0.058200 8.48e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 1.68e-01 0.057900 3.91e-01
CREB phosphorylation 7 7.92e-01 0.057400 8.97e-01
Phosphate bond hydrolysis by NTPDase proteins 5 8.24e-01 0.057300 9.19e-01
Ovarian tumor domain proteases 37 5.47e-01 0.057200 7.53e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 6.93e-01 -0.057000 8.40e-01
Metabolism of vitamins and cofactors 166 2.05e-01 -0.057000 4.37e-01
Mitotic Prophase 96 3.35e-01 0.057000 5.83e-01
Defective B3GAT3 causes JDSSDHD 11 7.44e-01 -0.056900 8.66e-01
Beta-oxidation of pristanoyl-CoA 9 7.68e-01 -0.056900 8.79e-01
Signaling by NTRKs 117 2.89e-01 0.056800 5.39e-01
Cellular Senescence 143 2.42e-01 0.056700 4.83e-01
Negative regulation of FGFR2 signaling 24 6.32e-01 0.056500 8.07e-01
TGFBR3 expression 20 6.63e-01 -0.056300 8.22e-01
Opioid Signalling 75 4.02e-01 0.055900 6.32e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 5.96e-01 0.055900 7.85e-01
Downregulation of ERBB2 signaling 24 6.38e-01 -0.055400 8.09e-01
Nephron development 5 8.30e-01 -0.055400 9.22e-01
Macroautophagy 128 2.83e-01 -0.054900 5.32e-01
EPH-ephrin mediated repulsion of cells 43 5.35e-01 -0.054700 7.43e-01
Signaling by PDGFR in disease 19 6.80e-01 0.054700 8.31e-01
Regulation of KIT signaling 15 7.15e-01 0.054500 8.48e-01
Processing of Intronless Pre-mRNAs 20 6.73e-01 -0.054500 8.28e-01
Regulation of pyruvate metabolism 32 5.95e-01 0.054200 7.84e-01
Cytochrome P450 - arranged by substrate type 38 5.63e-01 -0.054200 7.62e-01
Platelet calcium homeostasis 22 6.61e-01 0.054000 8.21e-01
Sema3A PAK dependent Axon repulsion 15 7.19e-01 -0.053600 8.49e-01
SUMOylation of transcription factors 16 7.11e-01 -0.053500 8.45e-01
Stimuli-sensing channels 81 4.06e-01 0.053400 6.36e-01
RHO GTPase cycle 412 6.31e-02 0.053400 2.10e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 8.37e-01 -0.053200 9.23e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 7.94e-01 0.053200 8.99e-01
RA biosynthesis pathway 13 7.40e-01 -0.053100 8.65e-01
Voltage gated Potassium channels 26 6.40e-01 0.053100 8.09e-01
Platelet homeostasis 69 4.49e-01 0.052700 6.71e-01
Apoptosis 158 2.55e-01 -0.052500 4.97e-01
Regulation of TP53 Activity through Association with Co-factors 13 7.44e-01 0.052300 8.66e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 5.89e-01 -0.052000 7.80e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.94e-01 0.052000 6.26e-01
MyD88-independent TLR4 cascade 108 3.51e-01 -0.052000 5.98e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 3.51e-01 -0.052000 5.98e-01
COPII-mediated vesicle transport 67 4.62e-01 0.051900 6.84e-01
Diseases associated with the TLR signaling cascade 29 6.28e-01 -0.051900 8.03e-01
Diseases of Immune System 29 6.28e-01 -0.051900 8.03e-01
Toll-like Receptor Cascades 162 2.54e-01 -0.051900 4.97e-01
Phosphate bond hydrolysis by NUDT proteins 7 8.12e-01 -0.051900 9.13e-01
Bacterial Infection Pathways 66 4.66e-01 0.051800 6.86e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 7.57e-01 -0.051700 8.73e-01
alpha-linolenic acid (ALA) metabolism 12 7.57e-01 -0.051700 8.73e-01
Inflammasomes 21 6.82e-01 -0.051600 8.31e-01
Toll Like Receptor 3 (TLR3) Cascade 104 3.64e-01 -0.051500 6.04e-01
Activation of SMO 13 7.48e-01 -0.051500 8.68e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 6.84e-01 0.051300 8.31e-01
Neurodegenerative Diseases 21 6.84e-01 0.051300 8.31e-01
CTLA4 inhibitory signaling 21 6.85e-01 0.051200 8.32e-01
G-protein beta:gamma signalling 29 6.34e-01 0.051100 8.08e-01
Regulation of NPAS4 gene expression 11 7.70e-01 -0.050900 8.80e-01
Formation of the beta-catenin:TCF transactivating complex 44 5.59e-01 0.050900 7.58e-01
Calnexin/calreticulin cycle 26 6.54e-01 0.050800 8.15e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 6.75e-01 -0.050500 8.30e-01
RNA Polymerase II Transcription 1206 3.46e-03 -0.050000 2.61e-02
GPCR ligand binding 241 1.82e-01 0.049900 4.07e-01
SUMO is proteolytically processed 6 8.33e-01 -0.049800 9.22e-01
Keratan sulfate biosynthesis 20 7.00e-01 0.049700 8.43e-01
Synthesis of IP3 and IP4 in the cytosol 22 6.88e-01 0.049500 8.35e-01
Regulation of MECP2 expression and activity 29 6.47e-01 -0.049200 8.10e-01
Gene expression (Transcription) 1413 1.96e-03 -0.049200 1.62e-02
Phase II - Conjugation of compounds 71 4.74e-01 0.049100 6.92e-01
Assembly of collagen fibrils and other multimeric structures 44 5.75e-01 0.048900 7.71e-01
TP53 Regulates Transcription of Cell Death Genes 43 5.79e-01 -0.048900 7.75e-01
Listeria monocytogenes entry into host cells 17 7.28e-01 -0.048800 8.56e-01
Diseases associated with O-glycosylation of proteins 50 5.52e-01 0.048600 7.54e-01
Transport of nucleotide sugars 9 8.03e-01 0.048100 9.05e-01
Signaling by GPCR 442 8.29e-02 0.048100 2.57e-01
Sensory processing of sound by inner hair cells of the cochlea 54 5.43e-01 -0.047900 7.48e-01
Regulation of lipid metabolism by PPARalpha 107 3.94e-01 -0.047700 6.26e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 8.05e-01 -0.047600 9.07e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 5.21e-01 -0.047500 7.29e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 8.28e-01 -0.047400 9.22e-01
RND1 GTPase cycle 37 6.19e-01 0.047300 7.98e-01
Muscle contraction 145 3.27e-01 0.047100 5.76e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 6.45e-01 -0.047000 8.10e-01
Reduction of cytosolic Ca++ levels 9 8.08e-01 0.046900 9.08e-01
RNA Polymerase I Promoter Clearance 64 5.17e-01 -0.046900 7.26e-01
RNA Polymerase I Transcription 64 5.17e-01 -0.046900 7.26e-01
Inositol phosphate metabolism 42 6.02e-01 0.046500 7.89e-01
Sodium/Proton exchangers 7 8.33e-01 -0.046100 9.22e-01
HDL remodeling 6 8.46e-01 -0.045800 9.27e-01
Ion transport by P-type ATPases 43 6.04e-01 -0.045700 7.90e-01
Formation of WDR5-containing histone-modifying complexes 42 6.09e-01 -0.045700 7.93e-01
IL-6-type cytokine receptor ligand interactions 13 7.76e-01 -0.045600 8.85e-01
Maturation of nucleoprotein 9694631 15 7.61e-01 0.045400 8.76e-01
Notch-HLH transcription pathway 28 6.78e-01 -0.045400 8.30e-01
Downregulation of TGF-beta receptor signaling 26 6.90e-01 0.045200 8.36e-01
mTORC1-mediated signalling 24 7.01e-01 -0.045200 8.43e-01
G alpha (s) signalling events 97 4.42e-01 0.045200 6.66e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 7.55e-01 0.045100 8.72e-01
Assembly and cell surface presentation of NMDA receptors 34 6.51e-01 0.044800 8.13e-01
Molybdenum cofactor biosynthesis 6 8.50e-01 -0.044700 9.30e-01
p38MAPK events 13 7.83e-01 0.044000 8.91e-01
Tight junction interactions 17 7.54e-01 -0.044000 8.72e-01
TCF dependent signaling in response to WNT 153 3.50e-01 -0.043800 5.98e-01
Synthesis of UDP-N-acetyl-glucosamine 8 8.31e-01 0.043500 9.22e-01
XBP1(S) activates chaperone genes 44 6.18e-01 0.043400 7.98e-01
Activation of the pre-replicative complex 32 6.72e-01 0.043300 8.27e-01
Signaling by NOTCH2 33 6.68e-01 0.043100 8.25e-01
Regulation of HMOX1 expression and activity 5 8.68e-01 0.043100 9.40e-01
Interleukin-15 signaling 14 7.82e-01 -0.042700 8.90e-01
RHOV GTPase cycle 36 6.58e-01 0.042700 8.19e-01
Metabolism of carbohydrates 241 2.54e-01 0.042700 4.97e-01
Receptor-type tyrosine-protein phosphatases 12 7.98e-01 0.042600 9.02e-01
Lysosome Vesicle Biogenesis 32 6.78e-01 -0.042500 8.30e-01
HCMV Early Events 84 5.02e-01 0.042400 7.13e-01
Regulation of PTEN localization 9 8.26e-01 0.042400 9.20e-01
MyD88 dependent cascade initiated on endosome 101 4.62e-01 -0.042300 6.84e-01
CaMK IV-mediated phosphorylation of CREB 9 8.27e-01 -0.042000 9.21e-01
Nucleotide catabolism 28 7.01e-01 -0.042000 8.43e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 6.16e-01 0.041900 7.96e-01
SARS-CoV Infections 433 1.37e-01 -0.041700 3.49e-01
Interleukin-1 family signaling 127 4.18e-01 -0.041600 6.45e-01
Immune System 1841 3.37e-03 0.041200 2.56e-02
PKMTs methylate histone lysines 44 6.37e-01 0.041200 8.08e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 8.51e-01 -0.041100 9.31e-01
Collagen formation 66 5.65e-01 0.040900 7.63e-01
Metabolism of steroids 125 4.33e-01 0.040600 6.58e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 8.75e-01 0.040500 9.43e-01
Neurotransmitter release cycle 38 6.66e-01 0.040500 8.25e-01
Phase 2 - plateau phase 11 8.17e-01 -0.040300 9.15e-01
Miscellaneous substrates 7 8.54e-01 -0.040300 9.33e-01
Cell-Cell communication 114 4.58e-01 0.040200 6.80e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 7.62e-01 -0.040200 8.77e-01
RUNX1 regulates estrogen receptor mediated transcription 6 8.65e-01 0.040100 9.40e-01
DNA Double-Strand Break Repair 137 4.19e-01 -0.040000 6.45e-01
Chromosome Maintenance 103 4.83e-01 -0.040000 6.98e-01
Telomere Extension By Telomerase 23 7.40e-01 -0.040000 8.65e-01
PPARA activates gene expression 105 4.80e-01 -0.039900 6.96e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 8.36e-01 0.039900 9.23e-01
TRAF6 mediated NF-kB activation 23 7.42e-01 -0.039600 8.66e-01
Metalloprotease DUBs 20 7.60e-01 -0.039400 8.76e-01
Lysine catabolism 11 8.22e-01 -0.039100 9.17e-01
DAG and IP3 signaling 34 6.96e-01 0.038700 8.41e-01
Activation of gene expression by SREBF (SREBP) 42 6.65e-01 0.038600 8.24e-01
NRAGE signals death through JNK 52 6.32e-01 -0.038400 8.07e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 8.61e-01 -0.038200 9.38e-01
Role of second messengers in netrin-1 signaling 6 8.72e-01 0.037900 9.41e-01
Toll Like Receptor 9 (TLR9) Cascade 108 4.97e-01 -0.037800 7.11e-01
CD28 dependent PI3K/Akt signaling 22 7.60e-01 -0.037600 8.76e-01
EPHB-mediated forward signaling 40 6.81e-01 0.037500 8.31e-01
Transport of vitamins, nucleosides, and related molecules 32 7.14e-01 -0.037500 8.47e-01
Adherens junctions interactions 41 6.80e-01 -0.037200 8.31e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 8.17e-01 0.037100 9.15e-01
Surfactant metabolism 21 7.69e-01 0.037000 8.80e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 7.40e-01 0.037000 8.65e-01
Signaling by NTRK1 (TRKA) 102 5.22e-01 0.036700 7.29e-01
Peptide hormone metabolism 54 6.44e-01 -0.036300 8.10e-01
Signaling by ERBB2 KD Mutants 20 7.80e-01 0.036000 8.89e-01
Nuclear Envelope (NE) Reassembly 68 6.08e-01 -0.036000 7.93e-01
Generic Transcription Pathway 1088 4.50e-02 -0.036000 1.73e-01
Interleukin receptor SHC signaling 23 7.65e-01 0.036000 8.78e-01
Mitophagy 38 7.02e-01 -0.035900 8.43e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 7.76e-01 -0.035800 8.86e-01
Biological oxidations 146 4.57e-01 -0.035600 6.80e-01
Cellular response to chemical stress 179 4.13e-01 -0.035500 6.41e-01
Formation of apoptosome 11 8.40e-01 -0.035100 9.24e-01
Regulation of the apoptosome activity 11 8.40e-01 -0.035100 9.24e-01
Mitotic Metaphase and Anaphase 212 3.79e-01 -0.035000 6.17e-01
Mitotic Anaphase 211 3.84e-01 -0.034700 6.20e-01
Regulation of endogenous retroelements 92 5.65e-01 -0.034700 7.63e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 7.16e-01 0.034600 8.48e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 5.53e-01 -0.034300 7.55e-01
G alpha (12/13) signalling events 68 6.27e-01 0.034100 8.03e-01
PINK1-PRKN Mediated Mitophagy 31 7.44e-01 -0.033900 8.66e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 8.15e-01 -0.033900 9.14e-01
Cell Cycle 611 1.53e-01 -0.033800 3.75e-01
Asparagine N-linked glycosylation 286 3.26e-01 0.033800 5.74e-01
DAP12 interactions 39 7.18e-01 0.033400 8.49e-01
Regulation of signaling by CBL 22 7.87e-01 0.033300 8.93e-01
SHC-mediated cascade:FGFR2 13 8.36e-01 -0.033200 9.23e-01
Adaptive Immune System 768 1.19e-01 0.033100 3.23e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 8.37e-01 0.033100 9.23e-01
Metabolism of lipids 642 1.54e-01 0.032900 3.75e-01
Diseases of programmed cell death 58 6.68e-01 0.032600 8.25e-01
Amino acids regulate mTORC1 48 6.97e-01 0.032500 8.41e-01
TYSND1 cleaves peroxisomal proteins 7 8.82e-01 -0.032400 9.47e-01
Separation of Sister Chromatids 168 4.71e-01 -0.032200 6.90e-01
Defective Intrinsic Pathway for Apoptosis 24 7.86e-01 -0.032000 8.93e-01
IkBA variant leads to EDA-ID 7 8.85e-01 -0.031600 9.49e-01
Mitotic Prometaphase 193 4.52e-01 0.031400 6.75e-01
M Phase 346 3.19e-01 -0.031200 5.67e-01
G2/M Checkpoints 126 5.49e-01 -0.030900 7.54e-01
WNT5A-dependent internalization of FZD4 13 8.47e-01 0.030800 9.28e-01
RHOU GTPase cycle 40 7.37e-01 0.030700 8.64e-01
Formation of axial mesoderm 6 8.97e-01 -0.030500 9.58e-01
p75NTR recruits signalling complexes 12 8.55e-01 0.030400 9.33e-01
Signaling by ALK fusions and activated point mutants 89 6.21e-01 -0.030400 7.98e-01
Signaling by ALK in cancer 89 6.21e-01 -0.030400 7.98e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 8.68e-01 -0.030300 9.40e-01
Defective B4GALT7 causes EDS, progeroid type 11 8.63e-01 -0.030000 9.39e-01
Adipogenesis 96 6.16e-01 -0.029700 7.96e-01
Sensory processing of sound 58 6.97e-01 -0.029600 8.41e-01
VEGFR2 mediated cell proliferation 18 8.29e-01 0.029400 9.22e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 8.60e-01 -0.029300 9.38e-01
Translation of Structural Proteins 9683701 29 7.86e-01 -0.029200 8.92e-01
Processing of DNA double-strand break ends 69 6.80e-01 0.028800 8.31e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 6.11e-01 -0.028700 7.95e-01
Protein folding 83 6.53e-01 -0.028500 8.15e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 7.13e-01 0.028400 8.47e-01
Deadenylation of mRNA 22 8.17e-01 -0.028400 9.15e-01
Deubiquitination 225 4.69e-01 0.028000 6.89e-01
Interleukin-6 family signaling 20 8.29e-01 -0.027900 9.22e-01
Pyruvate metabolism 44 7.49e-01 -0.027900 8.69e-01
Positive epigenetic regulation of rRNA expression 60 7.09e-01 -0.027900 8.45e-01
Estrogen-dependent gene expression 97 6.36e-01 0.027800 8.08e-01
Metabolism of steroid hormones 22 8.22e-01 -0.027800 9.17e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 8.59e-01 0.027300 9.37e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 7.38e-01 -0.027100 8.64e-01
Transcriptional Regulation by TP53 346 3.99e-01 -0.026400 6.29e-01
NOD1/2 Signaling Pathway 36 7.86e-01 -0.026200 8.92e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 9.20e-01 0.025900 9.65e-01
MECP2 regulates transcription factors 5 9.20e-01 0.025900 9.65e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 9.13e-01 0.025800 9.63e-01
RUNX3 regulates WNT signaling 8 8.99e-01 -0.025800 9.59e-01
Signal regulatory protein family interactions 13 8.72e-01 0.025800 9.41e-01
Signaling by KIT in disease 20 8.44e-01 -0.025500 9.26e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 8.44e-01 -0.025500 9.26e-01
Cardiac conduction 89 6.82e-01 0.025100 8.31e-01
PIP3 activates AKT signaling 235 5.08e-01 -0.025100 7.18e-01
FLT3 signaling through SRC family kinases 6 9.16e-01 -0.024900 9.64e-01
Regulation of TP53 Expression and Degradation 36 7.96e-01 0.024900 9.00e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 6.70e-01 0.024200 8.26e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 4.93e-01 -0.024000 7.08e-01
Zinc transporters 12 8.86e-01 0.023900 9.49e-01
Activation of caspases through apoptosome-mediated cleavage 6 9.19e-01 -0.023800 9.65e-01
Synthesis of PA 31 8.20e-01 -0.023600 9.16e-01
MITF-M-regulated melanocyte development 113 6.67e-01 0.023400 8.25e-01
SHC1 events in ERBB4 signaling 10 8.98e-01 0.023400 9.59e-01
DNA Damage Reversal 8 9.09e-01 -0.023300 9.62e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 9.00e-01 0.023000 9.59e-01
Defective EXT2 causes exostoses 2 10 9.00e-01 0.023000 9.59e-01
Cell Cycle, Mitotic 488 3.84e-01 -0.023000 6.20e-01
p75 NTR receptor-mediated signalling 89 7.08e-01 -0.023000 8.44e-01
TRP channels 22 8.53e-01 0.022900 9.32e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 9.30e-01 0.022800 9.69e-01
Maple Syrup Urine Disease 5 9.30e-01 0.022800 9.69e-01
Transport of small molecules 558 3.64e-01 0.022500 6.04e-01
MITF-M-dependent gene expression 83 7.25e-01 0.022400 8.53e-01
HDR through Homologous Recombination (HRR) 68 7.53e-01 -0.022000 8.72e-01
Chaperonin-mediated protein folding 77 7.38e-01 -0.022000 8.64e-01
Nef Mediated CD8 Down-regulation 7 9.20e-01 0.022000 9.65e-01
Signaling by FGFR in disease 52 7.84e-01 -0.021900 8.92e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 8.72e-01 -0.021900 9.41e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 8.72e-01 -0.021900 9.41e-01
Disease 1633 1.41e-01 -0.021800 3.56e-01
WNT mediated activation of DVL 8 9.15e-01 -0.021800 9.63e-01
ALK mutants bind TKIs 11 9.01e-01 -0.021800 9.60e-01
HCMV Late Events 67 7.60e-01 0.021600 8.76e-01
Acyl chain remodelling of PE 20 8.68e-01 -0.021500 9.40e-01
Cytoprotection by HMOX1 53 7.87e-01 0.021400 8.93e-01
Glucagon-type ligand receptors 20 8.70e-01 0.021100 9.41e-01
Glycolysis 68 7.65e-01 -0.021000 8.78e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 7.08e-01 0.020800 8.44e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 7.08e-01 0.020800 8.44e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 8.67e-01 0.020600 9.40e-01
Toll Like Receptor 4 (TLR4) Cascade 138 6.77e-01 -0.020500 8.30e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 8.46e-01 0.020500 9.27e-01
RHOBTB3 ATPase cycle 10 9.13e-01 -0.019900 9.63e-01
Diseases of glycosylation 109 7.23e-01 0.019700 8.52e-01
Cell death signalling via NRAGE, NRIF and NADE 69 7.79e-01 -0.019500 8.88e-01
Retrograde transport at the Trans-Golgi-Network 49 8.13e-01 -0.019500 9.13e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 9.07e-01 -0.019400 9.62e-01
VLDLR internalisation and degradation 16 8.93e-01 0.019400 9.55e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 8.05e-01 -0.019000 9.07e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 8.68e-01 -0.018900 9.40e-01
ERK/MAPK targets 22 8.79e-01 -0.018800 9.46e-01
Cell-cell junction organization 60 8.01e-01 -0.018800 9.04e-01
Signaling by Nuclear Receptors 214 6.38e-01 0.018700 8.09e-01
Ubiquinol biosynthesis 13 9.08e-01 -0.018600 9.62e-01
Cell Cycle Checkpoints 246 6.21e-01 0.018300 7.98e-01
SHC-mediated cascade:FGFR4 11 9.17e-01 -0.018100 9.64e-01
Acyl chain remodelling of PC 19 8.92e-01 0.017900 9.55e-01
Uptake and actions of bacterial toxins 28 8.71e-01 0.017700 9.41e-01
Phase 0 - rapid depolarisation 24 8.81e-01 -0.017700 9.47e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 9.02e-01 -0.017700 9.61e-01
Negative regulation of MAPK pathway 42 8.43e-01 -0.017600 9.26e-01
Ub-specific processing proteases 153 7.10e-01 -0.017400 8.45e-01
Circadian Clock 67 8.06e-01 -0.017400 9.07e-01
MHC class II antigen presentation 113 7.53e-01 -0.017100 8.72e-01
Ketone body metabolism 8 9.33e-01 0.017100 9.69e-01
Maturation of nucleoprotein 9683610 11 9.23e-01 0.016900 9.67e-01
Ion channel transport 141 7.31e-01 0.016800 8.60e-01
TRAF6 mediated IRF7 activation 15 9.12e-01 -0.016500 9.63e-01
Intracellular signaling by second messengers 268 6.45e-01 -0.016400 8.10e-01
Nuclear Envelope Breakdown 53 8.37e-01 -0.016300 9.23e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 8.80e-01 0.016100 9.47e-01
PECAM1 interactions 12 9.23e-01 -0.016100 9.67e-01
Signaling by NOTCH 175 7.16e-01 -0.015900 8.48e-01
RAF activation 33 8.74e-01 0.015900 9.43e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 9.10e-01 -0.015900 9.62e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 8.39e-01 -0.015800 9.23e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 8.39e-01 -0.015800 9.23e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 8.39e-01 -0.015800 9.23e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 8.39e-01 -0.015800 9.23e-01
Signaling by NOTCH1 in Cancer 55 8.39e-01 -0.015800 9.23e-01
HDR through Single Strand Annealing (SSA) 37 8.68e-01 -0.015800 9.40e-01
Class I MHC mediated antigen processing & presentation 344 6.14e-01 -0.015800 7.96e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 9.29e-01 -0.015500 9.69e-01
Negative epigenetic regulation of rRNA expression 63 8.35e-01 -0.015200 9.23e-01
FasL/ CD95L signaling 5 9.53e-01 0.015100 9.79e-01
Class B/2 (Secretin family receptors) 55 8.46e-01 -0.015100 9.27e-01
Transcriptional activation of mitochondrial biogenesis 52 8.56e-01 -0.014600 9.33e-01
Impaired BRCA2 binding to RAD51 35 8.82e-01 -0.014600 9.47e-01
TNFs bind their physiological receptors 25 9.01e-01 -0.014300 9.60e-01
Diseases of DNA repair 51 8.63e-01 -0.014000 9.39e-01
Formation of the nephric duct 8 9.45e-01 -0.014000 9.76e-01
MAPK family signaling cascades 264 6.97e-01 0.013900 8.41e-01
NoRC negatively regulates rRNA expression 60 8.55e-01 -0.013700 9.33e-01
Transferrin endocytosis and recycling 26 9.08e-01 -0.013100 9.62e-01
KEAP1-NFE2L2 pathway 107 8.18e-01 -0.012900 9.15e-01
ROS and RNS production in phagocytes 30 9.04e-01 0.012700 9.61e-01
Biosynthesis of DHA-derived SPMs 15 9.33e-01 0.012600 9.69e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 9.28e-01 0.012600 9.69e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 9.62e-01 -0.012400 9.86e-01
eNOS activation 12 9.42e-01 0.012100 9.74e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 8.85e-01 -0.012100 9.49e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 9.09e-01 -0.012000 9.62e-01
Chromatin modifying enzymes 215 7.64e-01 -0.011900 8.78e-01
Chromatin organization 215 7.64e-01 -0.011900 8.78e-01
Nitric oxide stimulates guanylate cyclase 15 9.37e-01 -0.011900 9.70e-01
Toll Like Receptor 2 (TLR2) Cascade 109 8.31e-01 0.011800 9.22e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 8.31e-01 0.011800 9.22e-01
Sensory perception of taste 22 9.26e-01 -0.011400 9.68e-01
Metabolism of amine-derived hormones 10 9.50e-01 -0.011400 9.78e-01
Signaling by Interleukins 391 6.99e-01 -0.011400 8.43e-01
Activation of ATR in response to replication stress 37 9.08e-01 0.011000 9.62e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 9.05e-01 -0.010900 9.62e-01
Signaling by FGFR 73 8.75e-01 -0.010600 9.43e-01
Response of Mtb to phagocytosis 22 9.32e-01 0.010600 9.69e-01
Cell junction organization 82 8.70e-01 0.010400 9.41e-01
Acyl chain remodelling of PG 11 9.53e-01 0.010200 9.79e-01
Nuclear signaling by ERBB4 24 9.31e-01 -0.010200 9.69e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 9.26e-01 -0.010100 9.68e-01
Diseases associated with surfactant metabolism 6 9.66e-01 -0.010000 9.87e-01
Free fatty acids regulate insulin secretion 10 9.57e-01 0.009930 9.81e-01
Signaling by NOTCH1 68 8.88e-01 0.009920 9.51e-01
FGFR3 ligand binding and activation 5 9.69e-01 0.009910 9.87e-01
FGFR3c ligand binding and activation 5 9.69e-01 0.009910 9.87e-01
Signaling by CSF3 (G-CSF) 29 9.28e-01 -0.009750 9.69e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 9.51e-01 -0.009470 9.78e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 9.51e-01 -0.009470 9.78e-01
G-protein mediated events 44 9.14e-01 0.009410 9.63e-01
CHL1 interactions 8 9.63e-01 0.009370 9.87e-01
NCAM signaling for neurite out-growth 48 9.15e-01 -0.008900 9.63e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 9.71e-01 0.008640 9.88e-01
Acyl chain remodeling of CL 5 9.73e-01 -0.008600 9.89e-01
Signalling to RAS 19 9.48e-01 0.008590 9.78e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 9.42e-01 -0.008520 9.74e-01
EGFR Transactivation by Gastrin 7 9.69e-01 -0.008370 9.87e-01
Modulation by Mtb of host immune system 7 9.69e-01 -0.008370 9.87e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.54e-01 -0.008330 9.79e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 9.33e-01 -0.008270 9.69e-01
DNA Double Strand Break Response 47 9.23e-01 -0.008100 9.67e-01
Signaling by FGFR2 61 9.13e-01 0.008060 9.63e-01
Protein ubiquitination 71 9.07e-01 0.007990 9.62e-01
Selective autophagy 77 9.04e-01 -0.007980 9.61e-01
HCMV Infection 106 8.91e-01 0.007680 9.54e-01
FGFRL1 modulation of FGFR1 signaling 7 9.72e-01 -0.007570 9.89e-01
Relaxin receptors 5 9.77e-01 -0.007530 9.91e-01
FGFR2 ligand binding and activation 9 9.69e-01 0.007420 9.87e-01
MTOR signalling 39 9.37e-01 -0.007340 9.70e-01
Interaction between L1 and Ankyrins 26 9.50e-01 -0.007150 9.78e-01
SUMOylation of transcription cofactors 44 9.35e-01 0.007100 9.70e-01
Regulation of TP53 Activity 153 8.82e-01 -0.006980 9.47e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.48e-01 0.006920 9.78e-01
The canonical retinoid cycle in rods (twilight vision) 9 9.72e-01 -0.006780 9.89e-01
Regulation of TP53 Activity through Phosphorylation 88 9.14e-01 0.006690 9.63e-01
TP53 Regulates Metabolic Genes 78 9.20e-01 0.006550 9.65e-01
Glycogen storage diseases 13 9.68e-01 -0.006460 9.87e-01
Epigenetic regulation of gene expression 263 8.64e-01 -0.006120 9.40e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 9.53e-01 -0.005500 9.79e-01
Aggrephagy 34 9.56e-01 -0.005440 9.81e-01
Developmental Biology 929 7.89e-01 -0.005170 8.95e-01
MyD88 cascade initiated on plasma membrane 95 9.34e-01 0.004910 9.69e-01
Toll Like Receptor 10 (TLR10) Cascade 95 9.34e-01 0.004910 9.69e-01
Toll Like Receptor 5 (TLR5) Cascade 95 9.34e-01 0.004910 9.69e-01
Transcriptional regulation of white adipocyte differentiation 77 9.42e-01 0.004780 9.74e-01
Zinc influx into cells by the SLC39 gene family 9 9.81e-01 -0.004690 9.93e-01
Unfolded Protein Response (UPR) 84 9.43e-01 0.004480 9.75e-01
TRAIL signaling 8 9.83e-01 0.004470 9.94e-01
MAPK1/MAPK3 signaling 232 9.07e-01 0.004450 9.62e-01
Post-translational protein modification 1243 7.92e-01 0.004450 8.97e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 9.65e-01 -0.003910 9.87e-01
Diseases of DNA Double-Strand Break Repair 41 9.65e-01 -0.003910 9.87e-01
Glycogen synthesis 11 9.83e-01 0.003640 9.94e-01
RAF/MAP kinase cascade 226 9.26e-01 -0.003580 9.68e-01
STAT5 Activation 7 9.87e-01 0.003480 9.94e-01
Heme degradation 11 9.84e-01 0.003390 9.94e-01
SUMOylation of intracellular receptors 26 9.77e-01 0.003300 9.91e-01
Transcriptional regulation by small RNAs 61 9.65e-01 0.003250 9.87e-01
Signaling by WNT 241 9.32e-01 0.003200 9.69e-01
Diseases of metabolism 208 9.40e-01 -0.003030 9.73e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 9.84e-01 0.003030 9.94e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 9.86e-01 0.002990 9.94e-01
ATF6 (ATF6-alpha) activates chaperones 12 9.86e-01 -0.002910 9.94e-01
Gene Silencing by RNA 87 9.64e-01 -0.002810 9.87e-01
p75NTR signals via NF-kB 15 9.85e-01 0.002750 9.94e-01
Regulation of TP53 Degradation 35 9.79e-01 -0.002600 9.92e-01
Striated Muscle Contraction 27 9.82e-01 -0.002510 9.94e-01
HDACs deacetylate histones 45 9.77e-01 -0.002460 9.91e-01
DAP12 signaling 28 9.84e-01 -0.002200 9.94e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 9.46e-01 -0.001960 9.77e-01
SLC transporter disorders 77 9.77e-01 0.001930 9.91e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 9.90e-01 0.001770 9.96e-01
Sensory processing of sound by outer hair cells of the cochlea 41 9.84e-01 0.001760 9.94e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 9.90e-01 0.001670 9.96e-01
NF-kB is activated and signals survival 12 9.94e-01 -0.001310 9.97e-01
Nucleotide-like (purinergic) receptors 13 9.94e-01 0.001220 9.97e-01
Interleukin-2 family signaling 38 9.91e-01 -0.001080 9.96e-01
Nicotinate metabolism 26 9.93e-01 -0.000945 9.97e-01
Respiratory syncytial virus (RSV) attachment and entry 18 9.95e-01 -0.000789 9.97e-01
Ion homeostasis 42 9.93e-01 0.000735 9.97e-01
Homologous DNA Pairing and Strand Exchange 43 9.94e-01 -0.000657 9.97e-01
Homology Directed Repair 110 9.93e-01 0.000490 9.97e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 9.95e-01 0.000483 9.97e-01
Cytochrome c-mediated apoptotic response 13 9.99e-01 0.000238 9.99e-01
Signaling by ERBB4 45 9.98e-01 -0.000217 9.99e-01
PLC beta mediated events 40 9.98e-01 0.000182 9.99e-01


Detailed Gene set reports



RUNX1 regulates expression of components of tight junctions
set RUNX1 regulates expression of components of tight junctions
setSize 5
pANOVA 0.00124
s.dist 0.834
p.adjustANOVA 0.0112


Top enriched genes
Top 20 genes
GeneID Gene Rank
CLDN5 10233
OCLN 8947
TJP1 8927
RUNX1 8626
CBFB 7092

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All member genes
GeneID Gene Rank
CLDN5 10233
OCLN 8947
TJP1 8927
RUNX1 8626
CBFB 7092


APOBEC3G mediated resistance to HIV-1 infection
set APOBEC3G mediated resistance to HIV-1 infection
setSize 5
pANOVA 0.00284
s.dist -0.771
p.adjustANOVA 0.0224


Top enriched genes
Top 20 genes
GeneID Gene Rank
APOBEC3G -10200
HMGA1 -9651
PSIP1 -9556
BANF1 -8457
PPIA -6549

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All member genes
GeneID Gene Rank
APOBEC3G -10200
HMGA1 -9651
PSIP1 -9556
BANF1 -8457
PPIA -6549


CD163 mediating an anti-inflammatory response
set CD163 mediating an anti-inflammatory response
setSize 9
pANOVA 7.64e-05
s.dist 0.761
p.adjustANOVA 0.00103


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD163 10588
ADAM17 10006
FURIN 9801
RHBDF2 9691
IL10 9023
MYH9 8774
MAPK14 7790
IL6 3956
PLK2 2034

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All member genes
GeneID Gene Rank
CD163 10588
ADAM17 10006
FURIN 9801
RHBDF2 9691
IL10 9023
MYH9 8774
MAPK14 7790
IL6 3956
PLK2 2034


Formation of the ureteric bud
set Formation of the ureteric bud
setSize 5
pANOVA 0.0033
s.dist 0.759
p.adjustANOVA 0.0253


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXC1 10557
GREM1 8831
WNT11 7475
ITGB1 7173
RET 5644

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All member genes
GeneID Gene Rank
FOXC1 10557
GREM1 8831
WNT11 7475
ITGB1 7173
RET 5644


RUNX1 regulates transcription of genes involved in BCR signaling
set RUNX1 regulates transcription of genes involved in BCR signaling
setSize 6
pANOVA 0.00147
s.dist 0.75
p.adjustANOVA 0.0128


Top enriched genes
Top 20 genes
GeneID Gene Rank
ELF1 9061
RUNX1 8626
BLK 8250
ELF2 7562
CBFB 7092
PAX5 6437

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All member genes
GeneID Gene Rank
ELF1 9061
RUNX1 8626
BLK 8250
ELF2 7562
CBFB 7092
PAX5 6437


Phenylalanine metabolism
set Phenylalanine metabolism
setSize 5
pANOVA 0.00432
s.dist -0.737
p.adjustANOVA 0.0301


Top enriched genes
Top 20 genes
GeneID Gene Rank
ASRGL1 -11388
IL4I1 -11321
KYAT1 -10192
QDPR -7662
PCBD1 -1994

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All member genes
GeneID Gene Rank
ASRGL1 -11388
IL4I1 -11321
KYAT1 -10192
QDPR -7662
PCBD1 -1994


Biosynthesis of Lipoxins (LX)
set Biosynthesis of Lipoxins (LX)
setSize 6
pANOVA 0.00253
s.dist 0.712
p.adjustANOVA 0.0202


Top enriched genes
Top 20 genes
GeneID Gene Rank
HPGD 10282
ALOX5AP 9685
ALOX5 9225
ALOX12 6561
PTGR1 6326
LTC4S 2429

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All member genes
GeneID Gene Rank
HPGD 10282
ALOX5AP 9685
ALOX5 9225
ALOX12 6561
PTGR1 6326
LTC4S 2429


RUNX3 regulates BCL2L11 (BIM) transcription
set RUNX3 regulates BCL2L11 (BIM) transcription
setSize 5
pANOVA 0.00797
s.dist 0.685
p.adjustANOVA 0.0486


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXO3 10556
BCL2L11 10265
RUNX3 8773
SMAD4 6355
SMAD3 -316

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All member genes
GeneID Gene Rank
FOXO3 10556
BCL2L11 10265
RUNX3 8773
SMAD4 6355
SMAD3 -316


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.000928
s.dist -0.676
p.adjustANOVA 0.00864


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLB -11252
LIG1 -11199
PARP2 -11126
APEX1 -10848
PARG -6049
PARP1 -4569
FEN1 -4242
ADPRS -3444

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLB -11252
LIG1 -11199
PARP2 -11126
APEX1 -10848
PARG -6049
PARP1 -4569
FEN1 -4242
ADPRS -3444


Peptide chain elongation
set Peptide chain elongation
setSize 88
pANOVA 8.35e-27
s.dist -0.66
p.adjustANOVA 2.3e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
RPS15 -6965
RPS3 -6941
EEF1A1 -6914
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
RPL28 -4606
RPS4X -4501
UBA52 -3283
RPL22L1 -2000
EEF2 -1954
RPS4Y1 -1386
RPS27L -782
RPL36AL 1886


Eukaryotic Translation Elongation
set Eukaryotic Translation Elongation
setSize 93
pANOVA 1.2e-27
s.dist -0.653
p.adjustANOVA 3.88e-25


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
EEF1B2 -10111
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
EEF1B2 -10111
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
EEF1G -7569
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
EEF1D -7031
RPS15 -6965
RPS3 -6941
EEF1A1 -6914
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
EEF1A2 -5609
RPL8 -5359
RPL15 -5298
RPS28 -5149
RPL28 -4606
RPS4X -4501
UBA52 -3283
RPL22L1 -2000
EEF2 -1954
RPS4Y1 -1386
RPS27L -782
EEF1A1P5 -295
RPL36AL 1886


Formation of a pool of free 40S subunits
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 7.61e-29
s.dist -0.644
p.adjustANOVA 4.9e-26


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3C -10844
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3C -10844
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
EIF3K -7973
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
EIF3G -7714
EIF3F -7661
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
RPS15 -6965
RPS3 -6941
RPL32 -6852
RPS23 -6839
RPLP0 -6800
EIF3D -6798
RPS29 -6553
RPL41 -6415
RPL3L -6199
EIF3I -6058
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
EIF3A -5501
EIF3H -5408
RPL8 -5359
RPL15 -5298
RPS28 -5149
EIF3L -5134
EIF3M -5066
EIF3J -4651
RPL28 -4606
EIF3E -4544
RPS4X -4501
EIF3B -3596
UBA52 -3283
RPL22L1 -2000
EIF1AX -1536
RPS4Y1 -1386
RPS27L -782
RPL36AL 1886


SARS-CoV-1 modulates host translation machinery
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 2.66e-11
s.dist -0.642
p.adjustANOVA 9.18e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS12 -10225
RPS18 -9927
RPS17 -9880
RPS27A -9819
RPS3A -9705
RPS8 -9133
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPS10 -8884
RPS25 -8690
RPS6 -8549
RPS21 -8500
RPS13 -8218
RPS2 -8082
RPS9 -7835
RPSA -7812
RPS5 -7775
RPS19 -7741
RPS26 -7627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS12 -10225
RPS18 -9927
RPS17 -9880
RPS27A -9819
RPS3A -9705
RPS8 -9133
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPS10 -8884
RPS25 -8690
RPS6 -8549
RPS21 -8500
RPS13 -8218
RPS2 -8082
RPS9 -7835
RPSA -7812
RPS5 -7775
RPS19 -7741
RPS26 -7627
RPS27 -7596
RPS7 -7532
FAU -7366
RPS15 -6965
RPS3 -6941
EEF1A1 -6914
RPS23 -6839
RPS29 -6553
HNRNPA1 -6347
RPS16 -6008
RPS11 -5913
RPS14 -5819
RPS28 -5149
RPS4X -4501
RPS4Y1 -1386
RPS27L -782


Eukaryotic Translation Termination
set Eukaryotic Translation Termination
setSize 92
pANOVA 1.99e-26
s.dist -0.641
p.adjustANOVA 4.27e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
TRMT112 -9250
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
TRMT112 -9250
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
N6AMT1 -8986
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
GSPT2 -7289
RPS15 -6965
RPS3 -6941
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
APEH -6252
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
RPL28 -4606
RPS4X -4501
UBA52 -3283
RPL22L1 -2000
RPS4Y1 -1386
RPS27L -782
RPL36AL 1886
ETF1 3469
GSPT1 8449


Viral mRNA Translation
set Viral mRNA Translation
setSize 88
pANOVA 2.42e-25
s.dist -0.641
p.adjustANOVA 3.59e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
RPS15 -6965
RPS3 -6941
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
RPL28 -4606
RPS4X -4501
UBA52 -3283
RPL22L1 -2000
RPS4Y1 -1386
RPS27L -782
GRSF1 1506
RPL36AL 1886
DNAJC3 8340


Selenocysteine synthesis
set Selenocysteine synthesis
setSize 92
pANOVA 7.03e-26
s.dist -0.634
p.adjustANOVA 1.13e-23


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
SARS1 -9886
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
SARS1 -9886
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
RPS15 -6965
RPS3 -6941
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
EEFSEC -6544
RPL41 -6415
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
RPL28 -4606
RPS4X -4501
UBA52 -3283
SEPHS2 -2775
RPL22L1 -2000
SECISBP2 -1493
RPS4Y1 -1386
RPS27L -782
RPL36AL 1886
PSTK 3872
SEPSECS 4131


RHOT1 GTPase cycle
set RHOT1 GTPase cycle
setSize 5
pANOVA 0.0148
s.dist 0.63
p.adjustANOVA 0.0815


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAP1GDS1 9553
TRAK2 9500
RHOT1 9487
TRAK1 3093
MYO19 946

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All member genes
GeneID Gene Rank
RAP1GDS1 9553
TRAK2 9500
RHOT1 9487
TRAK1 3093
MYO19 946


TNFR1-mediated ceramide production
set TNFR1-mediated ceramide production
setSize 6
pANOVA 0.00913
s.dist -0.615
p.adjustANOVA 0.0548


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNF -10876
SMPD2 -9882
NSMAF -8249
SMPD3 -6683
RACK1 -4846
TNFRSF1A -2463

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNF -10876
SMPD2 -9882
NSMAF -8249
SMPD3 -6683
RACK1 -4846
TNFRSF1A -2463


G2 Phase
set G2 Phase
setSize 5
pANOVA 0.0205
s.dist 0.598
p.adjustANOVA 0.1


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCNA1 10337
E2F3 10278
E2F1 7900
CCNA2 6923
CDK2 -4573

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNA1 10337
E2F3 10278
E2F1 7900
CCNA2 6923
CDK2 -4573


Propionyl-CoA catabolism
set Propionyl-CoA catabolism
setSize 5
pANOVA 0.0215
s.dist -0.594
p.adjustANOVA 0.104


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCEE -10669
MMAA -9867
PCCA -7352
PCCB -6908
MMUT 108

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCEE -10669
MMAA -9867
PCCA -7352
PCCB -6908
MMUT 108


Formation of xylulose-5-phosphate
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.0215
s.dist -0.594
p.adjustANOVA 0.104


Top enriched genes
Top 20 genes
GeneID Gene Rank
AKR1A1 -9620
DCXR -9393
SORD -8820
CRYL1 -5857
XYLB -995

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKR1A1 -9620
DCXR -9393
SORD -8820
CRYL1 -5857
XYLB -995


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 4.55e-23
s.dist -0.59
p.adjustANOVA 5.17e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
GSPT2 -7289
RPS15 -6965
RPS3 -6941
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
RPL28 -4606
RPS4X -4501
UBA52 -3283
NCBP2 -2615
RPL22L1 -2000
RPS4Y1 -1386
RPS27L -782
PABPC1 -326
NCBP1 1242
RPL36AL 1886
ETF1 3469
UPF1 6771
EIF4G1 8380
GSPT1 8449


NFE2L2 regulates pentose phosphate pathway genes
set NFE2L2 regulates pentose phosphate pathway genes
setSize 8
pANOVA 0.00406
s.dist 0.587
p.adjustANOVA 0.0288


Top enriched genes
Top 20 genes
GeneID Gene Rank
PGD 9775
G6PD 9096
CREBBP 7705
MAFG 6835
TKT 6172
NFE2L2 3243
TALDO1 3222
EP300 2293

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PGD 9775
G6PD 9096
CREBBP 7705
MAFG 6835
TKT 6172
NFE2L2 3243
TALDO1 3222
EP300 2293


GTP hydrolysis and joining of the 60S ribosomal subunit
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 1.39e-26
s.dist -0.586
p.adjustANOVA 3.37e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3C -10844
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3C -10844
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
EIF5B -8538
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
EIF3K -7973
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
EIF3G -7714
EIF3F -7661
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
EIF4A1 -7215
RPS15 -6965
RPS3 -6941
RPL32 -6852
EIF2S2 -6842
RPS23 -6839
RPLP0 -6800
EIF3D -6798
RPS29 -6553
RPL41 -6415
RPL3L -6199
EIF3I -6058
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
EIF3A -5501
EIF3H -5408
RPL8 -5359
RPL15 -5298
RPS28 -5149
EIF3L -5134
EIF3M -5066
EIF4A2 -4801
EIF3J -4651
RPL28 -4606
EIF3E -4544
RPS4X -4501
EIF3B -3596
UBA52 -3283
RPL22L1 -2000
EIF2S1 -1572
EIF1AX -1536
RPS4Y1 -1386
RPS27L -782
EIF4H -97
EIF5 -41
RPL36AL 1886
EIF4E 2374
EIF4B 3073
EIF2S3 4696
EIF4G1 8380


Translocation of ZAP-70 to Immunological synapse
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 6.92e-07
s.dist -0.585
p.adjustANOVA 1.63e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
LCK -11347
TRAC -11346
TRBC1 -11118
TRAV8-4 -10987
CD4 -10683
HLA-DPA1 -10630
HLA-DQA1 -10576
HLA-DRA -10563
ZAP70 -10115
TRBV12-3 -9904
CD3E -9121
HLA-DRB1 -8694
HLA-DPB1 -8580
CD247 -8100
HLA-DQB2 -7179
TRAV19 -7092
CD3D -5151
HLA-DQB1 -4575
HLA-DRB5 -4152
TRBV7-9 -2286

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LCK -11347
TRAC -11346
TRBC1 -11118
TRAV8-4 -10987
CD4 -10683
HLA-DPA1 -10630
HLA-DQA1 -10576
HLA-DRA -10563
ZAP70 -10115
TRBV12-3 -9904
CD3E -9121
HLA-DRB1 -8694
HLA-DPB1 -8580
CD247 -8100
HLA-DQB2 -7179
TRAV19 -7092
CD3D -5151
HLA-DQB1 -4575
HLA-DRB5 -4152
TRBV7-9 -2286
PTPN22 -1057
HLA-DQA2 -178
TRAV29DV5 2907
CD3G 6432


G2/M DNA replication checkpoint
set G2/M DNA replication checkpoint
setSize 5
pANOVA 0.0235
s.dist 0.585
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
WEE1 10352
PKMYT1 8160
CDK1 7316
CCNB2 6116
CCNB1 -1812

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WEE1 10352
PKMYT1 8160
CDK1 7316
CCNB2 6116
CCNB1 -1812


L13a-mediated translational silencing of Ceruloplasmin expression
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 2.96e-26
s.dist -0.584
p.adjustANOVA 5.72e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3C -10844
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3C -10844
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
EIF3K -7973
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
EIF3G -7714
EIF3F -7661
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
EIF4A1 -7215
RPS15 -6965
RPS3 -6941
RPL32 -6852
EIF2S2 -6842
RPS23 -6839
RPLP0 -6800
EIF3D -6798
RPS29 -6553
RPL41 -6415
RPL3L -6199
EIF3I -6058
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
EIF3A -5501
EIF3H -5408
RPL8 -5359
RPL15 -5298
RPS28 -5149
EIF3L -5134
EIF3M -5066
EIF4A2 -4801
EIF3J -4651
RPL28 -4606
EIF3E -4544
RPS4X -4501
EIF3B -3596
UBA52 -3283
RPL22L1 -2000
EIF2S1 -1572
EIF1AX -1536
RPS4Y1 -1386
RPS27L -782
PABPC1 -326
EIF4H -97
RPL36AL 1886
EIF4E 2374
EIF4B 3073
EIF2S3 4696
EIF4G1 8380


Cap-dependent Translation Initiation
set Cap-dependent Translation Initiation
setSize 118
pANOVA 5.86e-28
s.dist -0.583
p.adjustANOVA 2.26e-25


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3C -10844
EIF2B1 -10831
EIF2B3 -10717
RPL27A -10608
RPL13 -10378
EIF2B5 -10229
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3C -10844
EIF2B1 -10831
EIF2B3 -10717
RPL27A -10608
RPL13 -10378
EIF2B5 -10229
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
EIF5B -8538
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
EIF3K -7973
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
EIF3G -7714
EIF3F -7661
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
EIF4A1 -7215
RPS15 -6965
RPS3 -6941
RPL32 -6852
EIF2S2 -6842
RPS23 -6839
RPLP0 -6800
EIF3D -6798
RPS29 -6553
RPL41 -6415
RPL3L -6199
EIF3I -6058
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
EIF3A -5501
EIF3H -5408
RPL8 -5359
RPL15 -5298
RPS28 -5149
EIF3L -5134
EIF3M -5066
EIF4A2 -4801
EIF4EBP1 -4792
EIF3J -4651
RPL28 -4606
EIF2B2 -4584
EIF3E -4544
RPS4X -4501
EIF3B -3596
UBA52 -3283
EIF2B4 -3261
RPL22L1 -2000
EIF2S1 -1572
EIF1AX -1536
RPS4Y1 -1386
RPS27L -782
PABPC1 -326
EIF4H -97
EIF5 -41
RPL36AL 1886
EIF4E 2374
EIF4B 3073
EIF2S3 4696
EIF4G1 8380


Eukaryotic Translation Initiation
set Eukaryotic Translation Initiation
setSize 118
pANOVA 5.86e-28
s.dist -0.583
p.adjustANOVA 2.26e-25


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3C -10844
EIF2B1 -10831
EIF2B3 -10717
RPL27A -10608
RPL13 -10378
EIF2B5 -10229
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3C -10844
EIF2B1 -10831
EIF2B3 -10717
RPL27A -10608
RPL13 -10378
EIF2B5 -10229
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
EIF5B -8538
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
EIF3K -7973
RPL13A -7949
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
EIF3G -7714
EIF3F -7661
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
EIF4A1 -7215
RPS15 -6965
RPS3 -6941
RPL32 -6852
EIF2S2 -6842
RPS23 -6839
RPLP0 -6800
EIF3D -6798
RPS29 -6553
RPL41 -6415
RPL3L -6199
EIF3I -6058
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
EIF3A -5501
EIF3H -5408
RPL8 -5359
RPL15 -5298
RPS28 -5149
EIF3L -5134
EIF3M -5066
EIF4A2 -4801
EIF4EBP1 -4792
EIF3J -4651
RPL28 -4606
EIF2B2 -4584
EIF3E -4544
RPS4X -4501
EIF3B -3596
UBA52 -3283
EIF2B4 -3261
RPL22L1 -2000
EIF2S1 -1572
EIF1AX -1536
RPS4Y1 -1386
RPS27L -782
PABPC1 -326
EIF4H -97
EIF5 -41
RPL36AL 1886
EIF4E 2374
EIF4B 3073
EIF2S3 4696
EIF4G1 8380


CD22 mediated BCR regulation
set CD22 mediated BCR regulation
setSize 58
pANOVA 2.3e-14
s.dist 0.579
p.adjustANOVA 1.14e-12


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-29 10270
IGLV1-44 10151
IGHV4-34 9845
IGHV3-13 9490
IGKV2-30 9450
IGLC3 9400
IGHV2-5 9378
IGLV1-51 9137
IGHV2-70 8944
IGHV3-33 8906
IGLC7 8899
IGHV3-23 8864
IGLV7-43 8855
IGLV2-23 8809
IGKV3-15 8769
IGLC1 8744
IGKV1-33 8713
IGHV3-7 8651
IGKC 8512
IGLC2 8391

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-29 10270
IGLV1-44 10151
IGHV4-34 9845
IGHV3-13 9490
IGKV2-30 9450
IGLC3 9400
IGHV2-5 9378
IGLV1-51 9137
IGHV2-70 8944
IGHV3-33 8906
IGLC7 8899
IGHV3-23 8864
IGLV7-43 8855
IGLV2-23 8809
IGKV3-15 8769
IGLC1 8744
IGKV1-33 8713
IGHV3-7 8651
IGKC 8512
IGLC2 8391
IGHM 8322
IGHV4-59 8272
IGHV1-2 7938
IGLV2-8 7930
IGHV1-69 7879
IGKV2-28 7697
IGKV1D-39 7514
IGLV3-19 7507
IGHV1-46 7445
CD79A 7374
IGKV1-5 7305
IGLV1-40 6610
IGLV1-47 6103
IGKV2D-28 5950
IGHV3-30 5939
IGKV1-16 5506
IGKV4-1 5333
IGKV3-11 5175
IGLV2-11 5101
IGHV3-11 5051
IGLV6-57 4874
IGKV3-20 4795
IGLV3-25 4773
IGKV1-17 4625
IGHV3-53 4525
IGLV3-27 3961
IGLV3-1 3881
IGHV4-39 3479
IGHD 2851
CD22 2623
IGLV3-21 2422
IGLV2-14 1744
IGKV3D-20 151
IGKV1-12 96
IGHV3-48 -719
LYN -5495
CD79B -5597
PTPN6 -6349


Response of EIF2AK4 (GCN2) to amino acid deficiency
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 3.78e-23
s.dist -0.573
p.adjustANOVA 4.57e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATF3 -10789
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF3 -10789
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
ASNS -7943
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
RPS15 -6965
RPS3 -6941
RPL32 -6852
EIF2S2 -6842
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
RPL3L -6199
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
CEBPG -4780
RPL28 -4606
RPS4X -4501
DDIT3 -4467
UBA52 -3283
RPL22L1 -2000
ATF4 -1634
EIF2S1 -1572
RPS4Y1 -1386
RPS27L -782
RPL36AL 1886
TRIB3 3293
EIF2AK4 4300
ATF2 4485
EIF2S3 4696
IMPACT 5247
GCN1 5505
CEBPB 5977


Formation of the ternary complex, and subsequently, the 43S complex
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 1.47e-12
s.dist -0.573
p.adjustANOVA 6.18e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3C -10844
RPS12 -10225
RPS18 -9927
RPS17 -9880
RPS27A -9819
RPS3A -9705
RPS8 -9133
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPS10 -8884
RPS25 -8690
RPS6 -8549
RPS21 -8500
RPS13 -8218
RPS2 -8082
EIF3K -7973
RPS9 -7835
RPSA -7812
RPS5 -7775

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3C -10844
RPS12 -10225
RPS18 -9927
RPS17 -9880
RPS27A -9819
RPS3A -9705
RPS8 -9133
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPS10 -8884
RPS25 -8690
RPS6 -8549
RPS21 -8500
RPS13 -8218
RPS2 -8082
EIF3K -7973
RPS9 -7835
RPSA -7812
RPS5 -7775
RPS19 -7741
EIF3G -7714
EIF3F -7661
RPS26 -7627
RPS27 -7596
RPS7 -7532
FAU -7366
RPS15 -6965
RPS3 -6941
EIF2S2 -6842
RPS23 -6839
EIF3D -6798
RPS29 -6553
EIF3I -6058
RPS16 -6008
RPS11 -5913
RPS14 -5819
EIF3A -5501
EIF3H -5408
RPS28 -5149
EIF3L -5134
EIF3M -5066
EIF3J -4651
EIF3E -4544
RPS4X -4501
EIF3B -3596
EIF2S1 -1572
EIF1AX -1536
RPS4Y1 -1386
RPS27L -782
EIF2S3 4696


Scavenging of heme from plasma
set Scavenging of heme from plasma
setSize 70
pANOVA 1.36e-16
s.dist 0.571
p.adjustANOVA 9.38e-15


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD163 10588
IGKV2-29 10270
IGLV1-44 10151
IGHV4-34 9845
IGHA1 9567
IGHV3-13 9490
IGKV2-30 9450
IGLC3 9400
IGHV2-5 9378
IGLV7-46 9364
JCHAIN 9195
IGLV1-51 9137
IGLV4-69 8987
IGHV2-70 8944
IGHV3-33 8906
IGLC7 8899
IGHV3-23 8864
IGLV7-43 8855
IGLV2-23 8809
IGKV3-15 8769

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD163 10588
IGKV2-29 10270
IGLV1-44 10151
IGHV4-34 9845
IGHA1 9567
IGHV3-13 9490
IGKV2-30 9450
IGLC3 9400
IGHV2-5 9378
IGLV7-46 9364
JCHAIN 9195
IGLV1-51 9137
IGLV4-69 8987
IGHV2-70 8944
IGHV3-33 8906
IGLC7 8899
IGHV3-23 8864
IGLV7-43 8855
IGLV2-23 8809
IGKV3-15 8769
IGLC1 8744
IGKV1-33 8713
IGHV3-7 8651
IGKC 8512
IGLC2 8391
IGHV4-59 8272
HP 8170
IGHA2 7969
IGHV1-2 7938
IGLV2-8 7930
IGHV1-69 7879
IGLV10-54 7752
IGKV2-28 7697
IGKV1D-39 7514
IGLV3-19 7507
IGHV1-46 7445
IGKV1-5 7305
IGLV8-61 6698
IGLV1-40 6610
IGLV1-47 6103
IGKV2D-28 5950
IGHV3-30 5939
IGLV2-18 5571
IGKV1-16 5506
IGKV4-1 5333
IGKV3-11 5175
IGLV2-11 5101
IGHV3-11 5051
IGLV6-57 4874
IGKV3-20 4795
IGLV3-25 4773
IGKV1-17 4625
IGHV3-53 4525
LRP1 4232
IGLV3-27 3961
IGLV3-1 3881
IGHV4-39 3479
HBA1 3463
HBB 2944
IGLV5-45 2748
IGLV3-21 2422
IGLV2-14 1744
IGLV4-60 627
IGKV3D-20 151
IGKV1-12 96
IGLV1-36 -556
IGHV3-48 -719
HPX -6849
IGLV3-12 -10521
APOL1 -11249


Mitochondrial Uncoupling
set Mitochondrial Uncoupling
setSize 6
pANOVA 0.0162
s.dist -0.567
p.adjustANOVA 0.0855


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A14 -10977
UCP3 -9559
PM20D1 -9273
SLC25A27 -6052
UCP2 -2835
SLC25A4 -1164

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A14 -10977
UCP3 -9559
PM20D1 -9273
SLC25A27 -6052
UCP2 -2835
SLC25A4 -1164


MET activates PI3K/AKT signaling
set MET activates PI3K/AKT signaling
setSize 5
pANOVA 0.0282
s.dist 0.567
p.adjustANOVA 0.126


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF 10296
GAB1 10022
PIK3R1 8397
PIK3CA 794
GRB2 -392

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All member genes
GeneID Gene Rank
HGF 10296
GAB1 10022
PIK3R1 8397
PIK3CA 794
GRB2 -392


SARS-CoV-2 modulates host translation machinery
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 7.32e-12
s.dist -0.565
p.adjustANOVA 2.72e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS12 -10225
RPS18 -9927
RPS17 -9880
RPS27A -9819
RPS3A -9705
GEMIN6 -9255
SNRPD1 -9162
RPS8 -9133
RPS24 -9098
RPS15A -9094
RPS20 -9090
GEMIN8 -9006
RPS10 -8884
RPS25 -8690
SNRPE -8629
RPS6 -8549
RPS21 -8500
RPS13 -8218
RPS2 -8082
GEMIN7 -7913

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS12 -10225
RPS18 -9927
RPS17 -9880
RPS27A -9819
RPS3A -9705
GEMIN6 -9255
SNRPD1 -9162
RPS8 -9133
RPS24 -9098
RPS15A -9094
RPS20 -9090
GEMIN8 -9006
RPS10 -8884
RPS25 -8690
SNRPE -8629
RPS6 -8549
RPS21 -8500
RPS13 -8218
RPS2 -8082
GEMIN7 -7913
RPS9 -7835
RPSA -7812
SNRPD2 -7808
RPS5 -7775
RPS19 -7741
RPS26 -7627
RPS27 -7596
RPS7 -7532
FAU -7366
SNRPG -7106
RPS15 -6965
RPS3 -6941
RPS23 -6839
RPS29 -6553
SNRPD3 -6164
RPS16 -6008
RPS11 -5913
RPS14 -5819
SNRPB -5677
RPS28 -5149
SNRPF -5130
RPS4X -4501
GEMIN2 -2442
GEMIN4 -1680
RPS4Y1 -1386
GEMIN5 -991
RPS27L -782
SMN1 4747
DDX20 7179


YAP1- and WWTR1 (TAZ)-stimulated gene expression
set YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize 7
pANOVA 0.00992
s.dist 0.563
p.adjustANOVA 0.059


Top enriched genes
Top 20 genes
GeneID Gene Rank
HIPK2 10494
RUNX2 9855
HIPK1 9260
KAT2B 7639
NPPA 7466
WWTR1 5459
TEAD2 -9709

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIPK2 10494
RUNX2 9855
HIPK1 9260
KAT2B 7639
NPPA 7466
WWTR1 5459
TEAD2 -9709


RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
set RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
setSize 9
pANOVA 0.00347
s.dist 0.563
p.adjustANOVA 0.0261


Top enriched genes
Top 20 genes
GeneID Gene Rank
CR1 9869
CTLA4 9825
IL2RA 9714
RUNX1 8626
FOXP3 7285
CBFB 7092
TNFRSF18 6935
NFATC2 2567
IFNG -9909

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CR1 9869
CTLA4 9825
IL2RA 9714
RUNX1 8626
FOXP3 7285
CBFB 7092
TNFRSF18 6935
NFATC2 2567
IFNG -9909


Folding of actin by CCT/TriC
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.00215
s.dist -0.56
p.adjustANOVA 0.0175


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCT8 -9665
CCT4 -9126
CCT2 -8227
CCT7 -8091
CCT6A -7583
TCP1 -7392
CCT3 -5674
CCT5 -3955
CCT6B -3743
ACTB -2224

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -9665
CCT4 -9126
CCT2 -8227
CCT7 -8091
CCT6A -7583
TCP1 -7392
CCT3 -5674
CCT5 -3955
CCT6B -3743
ACTB -2224


Defective binding of VWF variant to GPIb:IX:V
set Defective binding of VWF variant to GPIb:IX:V
setSize 7
pANOVA 0.0122
s.dist 0.547
p.adjustANOVA 0.0701


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP9 8956
GP1BB 8228
VWF 7561
COL1A2 6110
COL1A1 5429
GP1BA 4441
GP5 -1490

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP9 8956
GP1BB 8228
VWF 7561
COL1A2 6110
COL1A1 5429
GP1BA 4441
GP5 -1490


Enhanced binding of GP1BA variant to VWF multimer:collagen
set Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize 7
pANOVA 0.0122
s.dist 0.547
p.adjustANOVA 0.0701


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP9 8956
GP1BB 8228
VWF 7561
COL1A2 6110
COL1A1 5429
GP1BA 4441
GP5 -1490

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP9 8956
GP1BB 8228
VWF 7561
COL1A2 6110
COL1A1 5429
GP1BA 4441
GP5 -1490


SRP-dependent cotranslational protein targeting to membrane
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 3.33e-23
s.dist -0.545
p.adjustANOVA 4.29e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL27A -10608
RPL13 -10378
RPS12 -10225
RPL9 -10053
RPL12 -10020
RPLP1 -9935
RPS18 -9927
RPS17 -9880
RPL34 -9850
RPS27A -9819
RPL39L -9776
RPS3A -9705
RPLP2 -9679
RPL21 -9598
RPL17 -9582
RPL23 -9562
RPL26 -9322
RPL31 -9293
RPL36A -9230
RPL35 -9137
RPL22 -9135
RPS8 -9133
RPL7 -9110
RPS24 -9098
RPS15A -9094
RPS20 -9090
RPL5 -9011
RPL14 -8932
RPS10 -8884
RPL19 -8784
RPL23A -8716
RPS25 -8690
SRP68 -8652
RPL10 -8600
RPS6 -8549
RPS21 -8500
RPL36 -8421
RPL3 -8388
RPL6 -8365
RPL11 -8332
RPL27 -8255
RPS13 -8218
RPL24 -8201
SEC11A -8185
RPL18 -8160
RPS2 -8082
RPL10A -8079
RPL29 -8058
RPL4 -8000
RPL13A -7949
SRP19 -7935
RPS9 -7835
RPSA -7812
RPL38 -7786
RPS5 -7775
RPL30 -7760
RPS19 -7741
RPL35A -7637
RPS26 -7627
RPL7A -7610
RPS27 -7596
RPL39 -7595
RPS7 -7532
FAU -7366
RPL18A -7344
RPL37A -7328
RPS15 -6965
RPS3 -6941
SSR2 -6927
RPL32 -6852
RPS23 -6839
RPLP0 -6800
RPS29 -6553
RPL41 -6415
RPL3L -6199
SRP14 -6121
RPL26L1 -6046
RPS16 -6008
RPS11 -5913
RPL37 -5908
RPS14 -5819
RPL8 -5359
RPL15 -5298
RPS28 -5149
SEC61G -4889
RPL28 -4606
RPS4X -4501
RPN2 -3915
SRP9 -3670
UBA52 -3283
SSR4 -3186
SSR1 -3174
SRPRB -3051
SEC61B -2981
SEC11C -2840
SRPRA -2021
RPL22L1 -2000
RPS4Y1 -1386
SPCS1 -1132
DDOST -1038
RPS27L -782
RPN1 -632
SEC61A2 -288
SRP54 1346
RPL36AL 1886
SPCS2 1893
SRP72 2984
SSR3 4006
SEC61A1 4488
TRAM1 6308
SPCS3 6331


Tandem pore domain potassium channels
set Tandem pore domain potassium channels
setSize 5
pANOVA 0.0355
s.dist -0.543
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
KCNK10 -11102
KCNK6 -10442
KCNK17 -5226
KCNK7 -2944
KCNK13 -2175

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All member genes
GeneID Gene Rank
KCNK10 -11102
KCNK6 -10442
KCNK17 -5226
KCNK7 -2944
KCNK13 -2175


Sperm Motility And Taxes
set Sperm Motility And Taxes
setSize 6
pANOVA 0.0221
s.dist -0.54
p.adjustANOVA 0.106


Top enriched genes
Top 20 genes
GeneID Gene Rank
HVCN1 -10087
CATSPER2 -9363
CATSPERG -8326
CATSPERB -6406
CATSPER1 -5502
CATSPER3 1632

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HVCN1 -10087
CATSPER2 -9363
CATSPERG -8326
CATSPERB -6406
CATSPER1 -5502
CATSPER3 1632


Classical antibody-mediated complement activation
set Classical antibody-mediated complement activation
setSize 69
pANOVA 1.05e-14
s.dist 0.538
p.adjustANOVA 5.79e-13


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-29 10270
IGLV1-44 10151
IGHV4-34 9845
IGHV3-13 9490
IGKV2-30 9450
IGLC3 9400
IGHV2-5 9378
IGLV7-46 9364
IGLV1-51 9137
IGLV4-69 8987
IGHV2-70 8944
IGHV3-33 8906
IGLC7 8899
IGHV3-23 8864
IGLV7-43 8855
IGLV2-23 8809
IGKV3-15 8769
IGLC1 8744
IGKV1-33 8713
IGHV3-7 8651

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-29 10270
IGLV1-44 10151
IGHV4-34 9845
IGHV3-13 9490
IGKV2-30 9450
IGLC3 9400
IGHV2-5 9378
IGLV7-46 9364
IGLV1-51 9137
IGLV4-69 8987
IGHV2-70 8944
IGHV3-33 8906
IGLC7 8899
IGHV3-23 8864
IGLV7-43 8855
IGLV2-23 8809
IGKV3-15 8769
IGLC1 8744
IGKV1-33 8713
IGHV3-7 8651
IGKC 8512
IGLC2 8391
IGHV4-59 8272
IGHV1-2 7938
IGLV2-8 7930
IGHV1-69 7879
IGLV10-54 7752
IGKV2-28 7697
IGKV1D-39 7514
IGLV3-19 7507
IGHV1-46 7445
IGKV1-5 7305
IGLV8-61 6698
IGLV1-40 6610
IGLV1-47 6103
IGKV2D-28 5950
IGHV3-30 5939
IGLV2-18 5571
IGKV1-16 5506
IGKV4-1 5333
IGKV3-11 5175
IGLV2-11 5101
IGHV3-11 5051
C1QB 5043
IGHG2 4916
IGLV6-57 4874
IGKV3-20 4795
IGLV3-25 4773
IGKV1-17 4625
IGHV3-53 4525
IGLV3-27 3961
IGLV3-1 3881
C1QC 3600
IGHV4-39 3479
IGHG3 3394
IGHG1 2873
IGLV5-45 2748
IGLV3-21 2422
IGLV2-14 1744
IGLV4-60 627
IGKV3D-20 151
IGKV1-12 96
C1QA -102
IGLV1-36 -556
IGHV3-48 -719
C1S -804
IGHG4 -1839
C1R -9900
IGLV3-12 -10521


Proton-coupled monocarboxylate transport
set Proton-coupled monocarboxylate transport
setSize 6
pANOVA 0.0226
s.dist 0.537
p.adjustANOVA 0.108


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC16A8 10076
SLC16A1 7706
EMB 6691
SLC16A3 4849
SLC16A7 4756
BSG -1065

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All member genes
GeneID Gene Rank
SLC16A8 10076
SLC16A1 7706
EMB 6691
SLC16A3 4849
SLC16A7 4756
BSG -1065


Aryl hydrocarbon receptor signalling
set Aryl hydrocarbon receptor signalling
setSize 6
pANOVA 0.0232
s.dist -0.535
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
AIP -10074
AHRR -9996
HSP90AB1 -8674
PTGES3 -8298
ARNT -7667
AHR 6964

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AIP -10074
AHRR -9996
HSP90AB1 -8674
PTGES3 -8298
ARNT -7667
AHR 6964


FASTK family proteins regulate processing and stability of mitochondrial RNAs
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 19
pANOVA 5.47e-05
s.dist 0.535
p.adjustANOVA 0.000771


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-ND1 9785
MT-ND4 9173
MT-ND2 9085
MT-RNR1 8727
MT-ND5 8671
MT-CYB 8458
MT-ATP6 8328
MT-RNR2 8108
MT-ND3 7830
MT-ND4L 7728
TBRG4 6653
MT-CO3 5576
MT-ND6 4972
MT-CO2 4838
MT-CO1 3757
FASTKD5 3240
MT-ATP8 1808
FASTK -5965
FASTKD2 -6903

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ND1 9785
MT-ND4 9173
MT-ND2 9085
MT-RNR1 8727
MT-ND5 8671
MT-CYB 8458
MT-ATP6 8328
MT-RNR2 8108
MT-ND3 7830
MT-ND4L 7728
TBRG4 6653
MT-CO3 5576
MT-ND6 4972
MT-CO2 4838
MT-CO1 3757
FASTKD5 3240
MT-ATP8 1808
FASTK -5965
FASTKD2 -6903


Inactivation of CDC42 and RAC1
set Inactivation of CDC42 and RAC1
setSize 7
pANOVA 0.0143
s.dist 0.535
p.adjustANOVA 0.0797


Top enriched genes
Top 20 genes
GeneID Gene Rank
SRGAP2 10565
SRGAP1 10549
CDC42 6906
SRGAP3 6868
ARHGAP39 4448
ROBO1 4093
RAC1 -5142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRGAP2 10565
SRGAP1 10549
CDC42 6906
SRGAP3 6868
ARHGAP39 4448
ROBO1 4093
RAC1 -5142


Protein repair
set Protein repair
setSize 6
pANOVA 0.0238
s.dist 0.533
p.adjustANOVA 0.112


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSRB3 9962
MSRB2 8529
MSRB1 6907
TXN 3679
MSRA 3429
PCMT1 197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSRB3 9962
MSRB2 8529
MSRB1 6907
TXN 3679
MSRA 3429
PCMT1 197


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Biosynthesis of Lipoxins (LX)`
## [1] "ALOX5"   "ALOX5AP" "HPGD"   
## 
## [[1]]$`UP genesets.CD163 mediating an anti-inflammatory response`
## [1] "ADAM17" "CD163"  "FURIN"  "IL10"   "RHBDF2"
## 
## [[1]]$`UP genesets.CD22 mediated BCR regulation`
## [1] "IGHV2-5"  "IGHV2-70" "IGHV3-13" "IGHV4-34" "IGKV2-29" "IGKV2-30" "IGLC3"   
## [8] "IGLV1-44" "IGLV1-51"
## 
## [[1]]$`UP genesets.Classical antibody-mediated complement activation`
##  [1] "IGHV2-5"  "IGHV2-70" "IGHV3-13" "IGHV4-34" "IGKV2-29" "IGKV2-30"
##  [7] "IGLC3"    "IGLV1-44" "IGLV1-51" "IGLV4-69" "IGLV7-46"
## 
## [[1]]$`UP genesets.Common Pathway of Fibrin Clot Formation`
## [1] "CD177" "F13A1" "F2R"   "F5"    "PF4"   "PRTN3"
## 
## [[1]]$`UP genesets.Creation of C4 and C2 activators`
##  [1] "IGHV2-5"  "IGHV2-70" "IGHV3-13" "IGHV4-34" "IGKV2-29" "IGKV2-30"
##  [7] "IGLC3"    "IGLV1-44" "IGLV1-51" "IGLV4-69" "IGLV7-46"
## 
## [[1]]$`UP genesets.FASTK family proteins regulate processing and stability of mitochondrial RNAs`
## [1] "MT-ND1" "MT-ND2" "MT-ND4"
## 
## [[1]]$`UP genesets.Formation of the ureteric bud`
## [1] "FOXC1"
## 
## [[1]]$`UP genesets.MET activates RAP1 and RAC1`
## [1] "GAB1" "HGF" 
## 
## [[1]]$`UP genesets.NFE2L2 regulates pentose phosphate pathway genes`
## [1] "G6PD" "PGD" 
## 
## [[1]]$`UP genesets.Prolonged ERK activation events`
## [1] "MAP2K1" "MAPK1"  "NTRK1" 
## 
## [[1]]$`UP genesets.RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)`
## [1] "CR1"   "CTLA4" "IL2RA"
## 
## [[1]]$`UP genesets.RUNX1 regulates expression of components of tight junctions`
## [1] "CLDN5" "OCLN" 
## 
## [[1]]$`UP genesets.RUNX1 regulates transcription of genes involved in BCR signaling`
## [1] "ELF1"
## 
## [[1]]$`UP genesets.RUNX3 regulates BCL2L11 (BIM) transcription`
## [1] "BCL2L11" "FOXO3"  
## 
## [[1]]$`UP genesets.Regulation of FOXO transcriptional activity by acetylation`
## [1] "FOXO3" "TXNIP"
## 
## [[1]]$`UP genesets.Replacement of protamines by nucleosomes in the male pronucleus`
## [1] "H2BC11" "H2BC12" "H2BC15" "H2BC17" "H2BC21" "H2BC4"  "H2BC5"  "H2BC9" 
## 
## [[1]]$`UP genesets.Role of LAT2/NTAL/LAB on calcium mobilization`
##  [1] "FYN"      "GAB2"     "IGHV2-5"  "IGHV2-70" "IGHV3-13" "IGHV4-34"
##  [7] "IGKV2-29" "IGKV2-30" "IGLC3"    "IGLV1-44" "IGLV1-51" "IGLV4-69"
## [13] "IGLV7-46" "PDPK1"   
## 
## [[1]]$`UP genesets.Scavenging of heme from plasma`
##  [1] "CD163"    "IGHA1"    "IGHV2-5"  "IGHV2-70" "IGHV3-13" "IGHV4-34"
##  [7] "IGKV2-29" "IGKV2-30" "IGLC3"    "IGLV1-44" "IGLV1-51" "IGLV4-69"
## [13] "IGLV7-46" "JCHAIN"  
## 
## [[1]]$`UP genesets.Signal attenuation`
## [1] "GRB10" "INSR"  "IRS1"  "IRS2"  "MAPK1"
## 
## [[1]]$`DOWN genesets.APOBEC3G mediated resistance to HIV-1 infection`
## [1] "APOBEC3G" "BANF1"    "HMGA1"    "PPIA"     "PSIP1"   
## 
## [[1]]$`DOWN genesets.Cap-dependent Translation Initiation`
##   [1] "EIF1AX"   "EIF2B1"   "EIF2B2"   "EIF2B3"   "EIF2B4"   "EIF2B5"  
##   [7] "EIF2S1"   "EIF2S2"   "EIF2S3"   "EIF3A"    "EIF3B"    "EIF3C"   
##  [13] "EIF3D"    "EIF3E"    "EIF3F"    "EIF3G"    "EIF3H"    "EIF3I"   
##  [19] "EIF3J"    "EIF3K"    "EIF3L"    "EIF3M"    "EIF4A1"   "EIF4A2"  
##  [25] "EIF4B"    "EIF4E"    "EIF4EBP1" "EIF4G1"   "EIF4H"    "EIF5"    
##  [31] "EIF5B"    "FAU"      "PABPC1"   "RPL10"    "RPL10A"   "RPL11"   
##  [37] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
##  [43] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
##  [49] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
##  [55] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
##  [61] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
##  [67] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
##  [73] "RPL3L"    "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"    
##  [79] "RPL7A"    "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"   
##  [85] "RPS10"    "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"   
##  [91] "RPS15A"   "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"    
##  [97] "RPS20"    "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"   
## [103] "RPS27"    "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"    
## [109] "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"    
## [115] "RPS8"     "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Elongation`
##  [1] "EEF1A1"   "EEF1A1P5" "EEF1A2"   "EEF1B2"   "EEF1D"    "EEF1G"   
##  [7] "EEF2"     "FAU"      "RPL10"    "RPL10A"   "RPL11"    "RPL12"   
## [13] "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"    "RPL18"   
## [19] "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1"  "RPL23"   
## [25] "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"    "RPL27A"  
## [31] "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"    "RPL32"   
## [37] "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"   "RPL36AL" 
## [43] "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"   "RPL3L"   
## [49] "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"     "RPL7A"   
## [55] "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"    "RPS10"   
## [61] "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"    "RPS15A"  
## [67] "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"     "RPS20"   
## [73] "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"    "RPS27"   
## [79] "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"     "RPS3A"   
## [85] "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"     "RPS8"    
## [91] "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Initiation`
##   [1] "EIF1AX"   "EIF2B1"   "EIF2B2"   "EIF2B3"   "EIF2B4"   "EIF2B5"  
##   [7] "EIF2S1"   "EIF2S2"   "EIF2S3"   "EIF3A"    "EIF3B"    "EIF3C"   
##  [13] "EIF3D"    "EIF3E"    "EIF3F"    "EIF3G"    "EIF3H"    "EIF3I"   
##  [19] "EIF3J"    "EIF3K"    "EIF3L"    "EIF3M"    "EIF4A1"   "EIF4A2"  
##  [25] "EIF4B"    "EIF4E"    "EIF4EBP1" "EIF4G1"   "EIF4H"    "EIF5"    
##  [31] "EIF5B"    "FAU"      "PABPC1"   "RPL10"    "RPL10A"   "RPL11"   
##  [37] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
##  [43] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
##  [49] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
##  [55] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
##  [61] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
##  [67] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
##  [73] "RPL3L"    "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"    
##  [79] "RPL7A"    "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"   
##  [85] "RPS10"    "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"   
##  [91] "RPS15A"   "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"    
##  [97] "RPS20"    "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"   
## [103] "RPS27"    "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"    
## [109] "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"    
## [115] "RPS8"     "RPS9"     "RPSA"     "UBA52"   
## 
## [[1]]$`DOWN genesets.Eukaryotic Translation Termination`
##  [1] "APEH"    "ETF1"    "FAU"     "GSPT1"   "GSPT2"   "N6AMT1"  "RPL10"  
##  [8] "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"  
## [15] "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1"
## [22] "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A" 
## [29] "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"  
## [36] "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A" 
## [43] "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"    "RPL41"   "RPL5"   
## [50] "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"  
## [57] "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"  
## [64] "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"  
## [71] "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A" 
## [78] "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1" 
## [85] "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"    "TRMT112"
## [92] "UBA52"  
## 
## [[1]]$`DOWN genesets.Folding of actin by CCT/TriC`
##  [1] "ACTB"  "CCT2"  "CCT3"  "CCT4"  "CCT5"  "CCT6A" "CCT6B" "CCT7"  "CCT8" 
## [10] "TCP1" 
## 
## [[1]]$`DOWN genesets.Formation of a pool of free 40S subunits`
##   [1] "EIF1AX"  "EIF3A"   "EIF3B"   "EIF3C"   "EIF3D"   "EIF3E"   "EIF3F"  
##   [8] "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"   "EIF3K"   "EIF3L"   "EIF3M"  
##  [15] "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A" 
##  [22] "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"  
##  [29] "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1"
##  [36] "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"  
##  [43] "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL"
##  [50] "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"   
##  [57] "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"   
##  [64] "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"  
##  [71] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
##  [78] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
##  [85] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
##  [92] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
##  [99] "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Formation of the ternary complex, and subsequently, the 43S complex`
##  [1] "EIF1AX" "EIF2S1" "EIF2S2" "EIF2S3" "EIF3A"  "EIF3B"  "EIF3C"  "EIF3D" 
##  [9] "EIF3E"  "EIF3F"  "EIF3G"  "EIF3H"  "EIF3I"  "EIF3J"  "EIF3K"  "EIF3L" 
## [17] "EIF3M"  "FAU"    "RPS10"  "RPS11"  "RPS12"  "RPS13"  "RPS14"  "RPS15" 
## [25] "RPS15A" "RPS16"  "RPS17"  "RPS18"  "RPS19"  "RPS2"   "RPS20"  "RPS21" 
## [33] "RPS23"  "RPS24"  "RPS25"  "RPS26"  "RPS27"  "RPS27A" "RPS27L" "RPS28" 
## [41] "RPS29"  "RPS3"   "RPS3A"  "RPS4X"  "RPS4Y1" "RPS5"   "RPS6"   "RPS7"  
## [49] "RPS8"   "RPS9"   "RPSA"  
## 
## [[1]]$`DOWN genesets.GTP hydrolysis and joining of the 60S ribosomal subunit`
##   [1] "EIF1AX"  "EIF2S1"  "EIF2S2"  "EIF2S3"  "EIF3A"   "EIF3B"   "EIF3C"  
##   [8] "EIF3D"   "EIF3E"   "EIF3F"   "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"  
##  [15] "EIF3K"   "EIF3L"   "EIF3M"   "EIF4A1"  "EIF4A2"  "EIF4B"   "EIF4E"  
##  [22] "EIF4G1"  "EIF4H"   "EIF5"    "EIF5B"   "FAU"     "RPL10"   "RPL10A" 
##  [29] "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"  
##  [36] "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"  
##  [43] "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"  
##  [50] "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"  
##  [57] "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"  
##  [64] "RPL39"   "RPL39L"  "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"   
##  [71] "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"  
##  [78] "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A" 
##  [85] "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"  
##  [92] "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L" 
##  [99] "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"   
## [106] "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.L13a-mediated translational silencing of Ceruloplasmin expression`
##   [1] "EIF1AX"  "EIF2S1"  "EIF2S2"  "EIF2S3"  "EIF3A"   "EIF3B"   "EIF3C"  
##   [8] "EIF3D"   "EIF3E"   "EIF3F"   "EIF3G"   "EIF3H"   "EIF3I"   "EIF3J"  
##  [15] "EIF3K"   "EIF3L"   "EIF3M"   "EIF4A1"  "EIF4A2"  "EIF4B"   "EIF4E"  
##  [22] "EIF4G1"  "EIF4H"   "FAU"     "PABPC1"  "RPL10"   "RPL10A"  "RPL11"  
##  [29] "RPL12"   "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"  
##  [36] "RPL18A"  "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A" 
##  [43] "RPL24"   "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"  
##  [50] "RPL3"    "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A" 
##  [57] "RPL36"   "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"  
##  [64] "RPL39L"  "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"   
##  [71] "RPL7A"   "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"  
##  [78] "RPS11"   "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"  
##  [85] "RPS17"   "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"  
##  [92] "RPS24"   "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"  
##  [99] "RPS29"   "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"   
## [106] "RPS7"    "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)`
##  [1] "EIF4G1"  "ETF1"    "FAU"     "GSPT1"   "GSPT2"   "NCBP1"   "NCBP2"  
##  [8] "PABPC1"  "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A" 
## [15] "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"  
## [22] "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1"
## [29] "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"  
## [36] "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL"
## [43] "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"   
## [50] "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"   
## [57] "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"  
## [64] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
## [71] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
## [78] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
## [85] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
## [92] "RPSA"    "UBA52"   "UPF1"   
## 
## [[1]]$`DOWN genesets.POLB-Dependent Long Patch Base Excision Repair`
## [1] "ADPRS" "APEX1" "FEN1"  "LIG1"  "PARG"  "PARP1" "PARP2" "POLB" 
## 
## [[1]]$`DOWN genesets.Peptide chain elongation`
##  [1] "EEF1A1"  "EEF2"    "FAU"     "RPL10"   "RPL10A"  "RPL11"   "RPL12"  
##  [8] "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A" 
## [15] "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"  
## [22] "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"   
## [29] "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"  
## [36] "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L" 
## [43] "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"  
## [50] "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"  
## [57] "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"  
## [64] "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"  
## [71] "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"  
## [78] "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"   
## [85] "RPS8"    "RPS9"    "RPSA"    "UBA52"  
## 
## [[1]]$`DOWN genesets.Phenylalanine metabolism`
## [1] "ASRGL1" "IL4I1"  "KYAT1"  "PCBD1"  "QDPR"  
## 
## [[1]]$`DOWN genesets.Response of EIF2AK4 (GCN2) to amino acid deficiency`
##   [1] "ASNS"    "ATF2"    "ATF3"    "ATF4"    "CEBPB"   "CEBPG"   "DDIT3"  
##   [8] "EIF2AK4" "EIF2S1"  "EIF2S2"  "EIF2S3"  "FAU"     "GCN1"    "IMPACT" 
##  [15] "RPL10"   "RPL10A"  "RPL11"   "RPL12"   "RPL13"   "RPL13A"  "RPL14"  
##  [22] "RPL15"   "RPL17"   "RPL18"   "RPL18A"  "RPL19"   "RPL21"   "RPL22"  
##  [29] "RPL22L1" "RPL23"   "RPL23A"  "RPL24"   "RPL26"   "RPL26L1" "RPL27"  
##  [36] "RPL27A"  "RPL28"   "RPL29"   "RPL3"    "RPL30"   "RPL31"   "RPL32"  
##  [43] "RPL34"   "RPL35"   "RPL35A"  "RPL36"   "RPL36A"  "RPL36AL" "RPL37"  
##  [50] "RPL37A"  "RPL38"   "RPL39"   "RPL39L"  "RPL3L"   "RPL4"    "RPL41"  
##  [57] "RPL5"    "RPL6"    "RPL7"    "RPL7A"   "RPL8"    "RPL9"    "RPLP0"  
##  [64] "RPLP1"   "RPLP2"   "RPS10"   "RPS11"   "RPS12"   "RPS13"   "RPS14"  
##  [71] "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"   "RPS2"   
##  [78] "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"   "RPS27"  
##  [85] "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"   "RPS4X"  
##  [92] "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"    "RPSA"   
##  [99] "TRIB3"   "UBA52"  
## 
## [[1]]$`DOWN genesets.SARS-CoV-1 modulates host translation machinery`
##  [1] "EEF1A1"  "FAU"     "HNRNPA1" "RPS10"   "RPS11"   "RPS12"   "RPS13"  
##  [8] "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"   "RPS18"   "RPS19"  
## [15] "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"   "RPS25"   "RPS26"  
## [22] "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"   "RPS3"    "RPS3A"  
## [29] "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"    "RPS8"    "RPS9"   
## [36] "RPSA"   
## 
## [[1]]$`DOWN genesets.SARS-CoV-2 modulates host translation machinery`
##  [1] "DDX20"  "FAU"    "GEMIN2" "GEMIN4" "GEMIN5" "GEMIN6" "GEMIN7" "GEMIN8"
##  [9] "RPS10"  "RPS11"  "RPS12"  "RPS13"  "RPS14"  "RPS15"  "RPS15A" "RPS16" 
## [17] "RPS17"  "RPS18"  "RPS19"  "RPS2"   "RPS20"  "RPS21"  "RPS23"  "RPS24" 
## [25] "RPS25"  "RPS26"  "RPS27"  "RPS27A" "RPS27L" "RPS28"  "RPS29"  "RPS3"  
## [33] "RPS3A"  "RPS4X"  "RPS4Y1" "RPS5"   "RPS6"   "RPS7"   "RPS8"   "RPS9"  
## [41] "RPSA"   "SMN1"   "SNRPB"  "SNRPD1" "SNRPD2" "SNRPD3" "SNRPE"  "SNRPF" 
## [49] "SNRPG" 
## 
## [[1]]$`DOWN genesets.Selenocysteine synthesis`
##  [1] "EEFSEC"   "FAU"      "PSTK"     "RPL10"    "RPL10A"   "RPL11"   
##  [7] "RPL12"    "RPL13"    "RPL13A"   "RPL14"    "RPL15"    "RPL17"   
## [13] "RPL18"    "RPL18A"   "RPL19"    "RPL21"    "RPL22"    "RPL22L1" 
## [19] "RPL23"    "RPL23A"   "RPL24"    "RPL26"    "RPL26L1"  "RPL27"   
## [25] "RPL27A"   "RPL28"    "RPL29"    "RPL3"     "RPL30"    "RPL31"   
## [31] "RPL32"    "RPL34"    "RPL35"    "RPL35A"   "RPL36"    "RPL36A"  
## [37] "RPL36AL"  "RPL37"    "RPL37A"   "RPL38"    "RPL39"    "RPL39L"  
## [43] "RPL3L"    "RPL4"     "RPL41"    "RPL5"     "RPL6"     "RPL7"    
## [49] "RPL7A"    "RPL8"     "RPL9"     "RPLP0"    "RPLP1"    "RPLP2"   
## [55] "RPS10"    "RPS11"    "RPS12"    "RPS13"    "RPS14"    "RPS15"   
## [61] "RPS15A"   "RPS16"    "RPS17"    "RPS18"    "RPS19"    "RPS2"    
## [67] "RPS20"    "RPS21"    "RPS23"    "RPS24"    "RPS25"    "RPS26"   
## [73] "RPS27"    "RPS27A"   "RPS27L"   "RPS28"    "RPS29"    "RPS3"    
## [79] "RPS3A"    "RPS4X"    "RPS4Y1"   "RPS5"     "RPS6"     "RPS7"    
## [85] "RPS8"     "RPS9"     "RPSA"     "SARS1"    "SECISBP2" "SEPHS2"  
## [91] "SEPSECS"  "UBA52"   
## 
## [[1]]$`DOWN genesets.Translocation of ZAP-70 to Immunological synapse`
##  [1] "CD247"     "CD3D"      "CD3E"      "CD3G"      "CD4"       "HLA-DPA1" 
##  [7] "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1"  "HLA-DQB2"  "HLA-DRA"  
## [13] "HLA-DRB1"  "HLA-DRB5"  "LCK"       "PTPN22"    "TRAC"      "TRAV19"   
## [19] "TRAV29DV5" "TRAV8-4"   "TRBC1"     "TRBV12-3"  "TRBV7-9"   "ZAP70"    
## 
## [[1]]$`DOWN genesets.Viral mRNA Translation`
##  [1] "DNAJC3"  "FAU"     "GRSF1"   "RPL10"   "RPL10A"  "RPL11"   "RPL12"  
##  [8] "RPL13"   "RPL13A"  "RPL14"   "RPL15"   "RPL17"   "RPL18"   "RPL18A" 
## [15] "RPL19"   "RPL21"   "RPL22"   "RPL22L1" "RPL23"   "RPL23A"  "RPL24"  
## [22] "RPL26"   "RPL26L1" "RPL27"   "RPL27A"  "RPL28"   "RPL29"   "RPL3"   
## [29] "RPL30"   "RPL31"   "RPL32"   "RPL34"   "RPL35"   "RPL35A"  "RPL36"  
## [36] "RPL36A"  "RPL36AL" "RPL37"   "RPL37A"  "RPL38"   "RPL39"   "RPL39L" 
## [43] "RPL3L"   "RPL4"    "RPL41"   "RPL5"    "RPL6"    "RPL7"    "RPL7A"  
## [50] "RPL8"    "RPL9"    "RPLP0"   "RPLP1"   "RPLP2"   "RPS10"   "RPS11"  
## [57] "RPS12"   "RPS13"   "RPS14"   "RPS15"   "RPS15A"  "RPS16"   "RPS17"  
## [64] "RPS18"   "RPS19"   "RPS2"    "RPS20"   "RPS21"   "RPS23"   "RPS24"  
## [71] "RPS25"   "RPS26"   "RPS27"   "RPS27A"  "RPS27L"  "RPS28"   "RPS29"  
## [78] "RPS3"    "RPS3A"   "RPS4X"   "RPS4Y1"  "RPS5"    "RPS6"    "RPS7"   
## [85] "RPS8"    "RPS9"    "RPSA"    "UBA52"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report