date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.8883309
A1BG 1.0619003
A1BG-AS1 -0.0763145
A1CF 0.2105206
A2M -1.3534756
A2M-AS1 -0.0585167

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21253
duplicated_genes_present 0
num_profile_genes_in_sets 8700
num_profile_genes_not_in_sets 12553

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1198
num_genesets_included 1527

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Establishment of Sister Chromatid Cohesion 11 8.95e-06 -0.773 0.00123
Defective binding of VWF variant to GPIb:IX:V 5 3.76e-03 0.748 0.09900
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 3.76e-03 0.748 0.09900
Defects of platelet adhesion to exposed collagen 6 1.54e-03 0.747 0.05330
Sulfide oxidation to sulfate 5 4.44e-03 0.735 0.11200
MET activates PI3K/AKT signaling 5 6.08e-03 -0.708 0.14200
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 8.06e-03 0.684 0.16300
Activation of caspases through apoptosome-mediated cleavage 6 4.32e-03 -0.673 0.11200
Cohesin Loading onto Chromatin 10 2.33e-04 -0.672 0.01460
ARMS-mediated activation 6 5.25e-03 -0.658 0.12800
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 1.09e-02 0.657 0.18300
Synthesis of PI 5 1.26e-02 0.644 0.18600
Neurotransmitter clearance 6 8.72e-03 0.618 0.17200
Fructose metabolism 7 5.12e-03 0.611 0.12800
Fructose catabolism 5 1.94e-02 0.604 0.23200
ALK mutants bind TKIs 11 8.32e-04 -0.582 0.03550
Wax and plasmalogen biosynthesis 5 2.65e-02 -0.573 0.27100
Synthesis of PIPs at the late endosome membrane 11 1.27e-03 -0.561 0.04710
Regulation of IFNG signaling 14 3.42e-04 -0.553 0.01990
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 3.27e-02 0.551 0.29900
Regulation of TP53 Activity through Association with Co-factors 11 1.73e-03 0.546 0.05630
SMAC (DIABLO) binds to IAPs 7 1.29e-02 -0.543 0.18600
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.29e-02 -0.543 0.18600
SMAC, XIAP-regulated apoptotic response 7 1.29e-02 -0.543 0.18600
Toxicity of botulinum toxin type D (botD) 5 3.65e-02 0.540 0.30100
Toxicity of botulinum toxin type F (botF) 5 3.65e-02 0.540 0.30100
CDC6 association with the ORC:origin complex 8 9.07e-03 -0.533 0.17400
Defective factor IX causes hemophilia B 6 2.49e-02 0.529 0.26300
Mitotic Telophase/Cytokinesis 13 1.07e-03 -0.524 0.04370
Synthesis of 12-eicosatetraenoic acid derivatives 6 2.63e-02 0.524 0.27000
Adenylate cyclase activating pathway 8 1.07e-02 0.521 0.18200
Diseases of Mismatch Repair (MMR) 5 4.44e-02 -0.519 0.32600
OAS antiviral response 8 1.11e-02 -0.518 0.18300
SUMO is proteolytically processed 6 2.79e-02 -0.518 0.27600
Cobalamin (Cbl) metabolism 7 1.77e-02 -0.518 0.22000
Transcriptional regulation of testis differentiation 5 4.56e-02 0.516 0.32800
Synthesis of GDP-mannose 6 3.00e-02 0.512 0.28900
Formation of the active cofactor, UDP-glucuronate 5 4.79e-02 -0.511 0.33700
Degradation of cysteine and homocysteine 12 2.51e-03 0.504 0.07140
E2F-enabled inhibition of pre-replication complex formation 9 8.89e-03 -0.504 0.17200
RUNX1 regulates transcription of genes involved in BCR signaling 6 3.28e-02 -0.503 0.29900
Small interfering RNA (siRNA) biogenesis 9 1.06e-02 -0.492 0.18200
Activation of the TFAP2 (AP-2) family of transcription factors 7 2.45e-02 0.491 0.26200
Synthesis of PIPs at the early endosome membrane 16 7.13e-04 -0.489 0.03340
HDL remodeling 6 3.91e-02 0.486 0.31200
Gain-of-function MRAS complexes activate RAF signaling 8 1.89e-02 -0.479 0.22700
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.89e-02 -0.479 0.22700
Signaling by MRAS-complex mutants 8 1.89e-02 -0.479 0.22700
RUNX3 regulates CDKN1A transcription 7 3.23e-02 0.467 0.29700
Regulation of PTEN mRNA translation 12 5.23e-03 -0.466 0.12800


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Establishment of Sister Chromatid Cohesion 11 8.95e-06 -7.73e-01 1.23e-03
Defective binding of VWF variant to GPIb:IX:V 5 3.76e-03 7.48e-01 9.90e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 3.76e-03 7.48e-01 9.90e-02
Defects of platelet adhesion to exposed collagen 6 1.54e-03 7.47e-01 5.33e-02
Sulfide oxidation to sulfate 5 4.44e-03 7.35e-01 1.12e-01
MET activates PI3K/AKT signaling 5 6.08e-03 -7.08e-01 1.42e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 8.06e-03 6.84e-01 1.63e-01
Activation of caspases through apoptosome-mediated cleavage 6 4.32e-03 -6.73e-01 1.12e-01
Cohesin Loading onto Chromatin 10 2.33e-04 -6.72e-01 1.46e-02
ARMS-mediated activation 6 5.25e-03 -6.58e-01 1.28e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 1.09e-02 6.57e-01 1.83e-01
Synthesis of PI 5 1.26e-02 6.44e-01 1.86e-01
Neurotransmitter clearance 6 8.72e-03 6.18e-01 1.72e-01
Fructose metabolism 7 5.12e-03 6.11e-01 1.28e-01
Fructose catabolism 5 1.94e-02 6.04e-01 2.32e-01
ALK mutants bind TKIs 11 8.32e-04 -5.82e-01 3.55e-02
Wax and plasmalogen biosynthesis 5 2.65e-02 -5.73e-01 2.71e-01
Synthesis of PIPs at the late endosome membrane 11 1.27e-03 -5.61e-01 4.71e-02
Regulation of IFNG signaling 14 3.42e-04 -5.53e-01 1.99e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 3.27e-02 5.51e-01 2.99e-01
Regulation of TP53 Activity through Association with Co-factors 11 1.73e-03 5.46e-01 5.63e-02
SMAC (DIABLO) binds to IAPs 7 1.29e-02 -5.43e-01 1.86e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.29e-02 -5.43e-01 1.86e-01
SMAC, XIAP-regulated apoptotic response 7 1.29e-02 -5.43e-01 1.86e-01
Toxicity of botulinum toxin type D (botD) 5 3.65e-02 5.40e-01 3.01e-01
Toxicity of botulinum toxin type F (botF) 5 3.65e-02 5.40e-01 3.01e-01
CDC6 association with the ORC:origin complex 8 9.07e-03 -5.33e-01 1.74e-01
Defective factor IX causes hemophilia B 6 2.49e-02 5.29e-01 2.63e-01
Mitotic Telophase/Cytokinesis 13 1.07e-03 -5.24e-01 4.37e-02
Synthesis of 12-eicosatetraenoic acid derivatives 6 2.63e-02 5.24e-01 2.70e-01
Adenylate cyclase activating pathway 8 1.07e-02 5.21e-01 1.82e-01
Diseases of Mismatch Repair (MMR) 5 4.44e-02 -5.19e-01 3.26e-01
OAS antiviral response 8 1.11e-02 -5.18e-01 1.83e-01
SUMO is proteolytically processed 6 2.79e-02 -5.18e-01 2.76e-01
Cobalamin (Cbl) metabolism 7 1.77e-02 -5.18e-01 2.20e-01
Transcriptional regulation of testis differentiation 5 4.56e-02 5.16e-01 3.28e-01
Synthesis of GDP-mannose 6 3.00e-02 5.12e-01 2.89e-01
Formation of the active cofactor, UDP-glucuronate 5 4.79e-02 -5.11e-01 3.37e-01
Degradation of cysteine and homocysteine 12 2.51e-03 5.04e-01 7.14e-02
E2F-enabled inhibition of pre-replication complex formation 9 8.89e-03 -5.04e-01 1.72e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 3.28e-02 -5.03e-01 2.99e-01
Small interfering RNA (siRNA) biogenesis 9 1.06e-02 -4.92e-01 1.82e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 2.45e-02 4.91e-01 2.62e-01
Synthesis of PIPs at the early endosome membrane 16 7.13e-04 -4.89e-01 3.34e-02
HDL remodeling 6 3.91e-02 4.86e-01 3.12e-01
Gain-of-function MRAS complexes activate RAF signaling 8 1.89e-02 -4.79e-01 2.27e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.89e-02 -4.79e-01 2.27e-01
Signaling by MRAS-complex mutants 8 1.89e-02 -4.79e-01 2.27e-01
RUNX3 regulates CDKN1A transcription 7 3.23e-02 4.67e-01 2.97e-01
Regulation of PTEN mRNA translation 12 5.23e-03 -4.66e-01 1.28e-01
Killing mechanisms 9 1.66e-02 4.61e-01 2.11e-01
WNT5:FZD7-mediated leishmania damping 9 1.66e-02 4.61e-01 2.11e-01
Interleukin-6 signaling 10 1.18e-02 -4.60e-01 1.86e-01
Thyroxine biosynthesis 5 7.89e-02 4.54e-01 4.11e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.41e-02 -4.48e-01 1.96e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 5.85e-02 4.46e-01 3.55e-01
N-glycan trimming and elongation in the cis-Golgi 5 8.51e-02 -4.45e-01 4.18e-01
Phenylalanine metabolism 5 8.91e-02 4.39e-01 4.28e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 4.60e-02 4.36e-01 3.28e-01
Crosslinking of collagen fibrils 12 9.14e-03 4.35e-01 1.74e-01
Regulation of IFNA/IFNB signaling 12 9.33e-03 -4.33e-01 1.76e-01
Cytosolic iron-sulfur cluster assembly 13 7.02e-03 4.32e-01 1.53e-01
Fibronectin matrix formation 6 6.72e-02 4.31e-01 3.80e-01
Diseases of hemostasis 13 7.15e-03 4.31e-01 1.53e-01
Post-transcriptional silencing by small RNAs 7 4.85e-02 -4.31e-01 3.39e-01
Acetylcholine Neurotransmitter Release Cycle 11 1.48e-02 4.24e-01 2.01e-01
Synthesis of 5-eicosatetraenoic acids 7 5.20e-02 4.24e-01 3.45e-01
ROBO receptors bind AKAP5 7 5.29e-02 -4.23e-01 3.48e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 5.56e-02 4.18e-01 3.55e-01
Interferon alpha/beta signaling 63 1.10e-08 -4.16e-01 7.02e-06
CREB phosphorylation 7 5.67e-02 -4.16e-01 3.55e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 1.08e-01 -4.15e-01 4.48e-01
Maple Syrup Urine Disease 5 1.08e-01 -4.15e-01 4.48e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 5.79e-02 -4.14e-01 3.55e-01
Signaling by PDGFR in disease 19 1.92e-03 -4.11e-01 5.96e-02
Butyrophilin (BTN) family interactions 10 2.50e-02 4.09e-01 2.63e-01
PDH complex synthesizes acetyl-CoA from PYR 5 1.14e-01 -4.08e-01 4.51e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.51e-02 4.05e-01 2.01e-01
Norepinephrine Neurotransmitter Release Cycle 14 8.70e-03 4.05e-01 1.72e-01
Neurotoxicity of clostridium toxins 9 3.61e-02 4.03e-01 3.01e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 8.73e-02 4.03e-01 4.25e-01
Cytochrome c-mediated apoptotic response 13 1.23e-02 -4.01e-01 1.86e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 8.96e-02 -4.00e-01 4.29e-01
Maturation of hRSV A proteins 13 1.33e-02 -3.97e-01 1.91e-01
Propionyl-CoA catabolism 5 1.29e-01 -3.92e-01 4.76e-01
Zygotic genome activation (ZGA) 5 1.29e-01 3.92e-01 4.76e-01
Protein lipoylation 10 3.19e-02 -3.92e-01 2.96e-01
Activation of PUMA and translocation to mitochondria 8 5.51e-02 3.92e-01 3.55e-01
Phospholipase C-mediated cascade: FGFR1 8 5.52e-02 3.91e-01 3.55e-01
Sensing of DNA Double Strand Breaks 6 9.90e-02 -3.89e-01 4.39e-01
ATF6 (ATF6-alpha) activates chaperones 12 2.01e-02 -3.88e-01 2.37e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 5.77e-02 3.88e-01 3.55e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 7.66e-03 -3.85e-01 1.56e-01
Impaired BRCA2 binding to RAD51 35 8.66e-05 -3.83e-01 6.40e-03
GP1b-IX-V activation signalling 10 3.59e-02 3.83e-01 3.01e-01
Ca2+ activated K+ channels 6 1.04e-01 3.83e-01 4.42e-01
GDP-fucose biosynthesis 6 1.06e-01 3.81e-01 4.44e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.86e-02 -3.81e-01 2.79e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.11e-01 -3.76e-01 4.49e-01
The canonical retinoid cycle in rods (twilight vision) 9 5.17e-02 3.74e-01 3.45e-01
Deadenylation of mRNA 22 2.40e-03 -3.74e-01 7.14e-02
Signaling by cytosolic FGFR1 fusion mutants 18 6.07e-03 -3.74e-01 1.42e-01
Processing and activation of SUMO 10 4.20e-02 -3.71e-01 3.22e-01
Regulation of CDH19 Expression and Function 5 1.50e-01 3.71e-01 5.00e-01
Signaling by LTK in cancer 7 9.02e-02 -3.70e-01 4.30e-01
Anchoring fibril formation 7 9.07e-02 3.69e-01 4.30e-01
G2/M DNA replication checkpoint 5 1.61e-01 -3.62e-01 5.11e-01
Interleukin-20 family signaling 17 9.84e-03 -3.62e-01 1.79e-01
Condensation of Prometaphase Chromosomes 11 3.84e-02 -3.61e-01 3.10e-01
Signaling by PDGFRA extracellular domain mutants 12 3.07e-02 -3.60e-01 2.90e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.07e-02 -3.60e-01 2.90e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 1.01e-01 3.58e-01 4.39e-01
Glucuronidation 8 7.98e-02 -3.58e-01 4.11e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 1.30e-01 3.56e-01 4.77e-01
Platelet Aggregation (Plug Formation) 28 1.12e-03 3.56e-01 4.45e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 6.47e-02 -3.56e-01 3.73e-01
Impaired BRCA2 binding to PALB2 24 2.57e-03 -3.55e-01 7.14e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 1.75e-01 -3.50e-01 5.35e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 1.75e-01 -3.50e-01 5.35e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 5.53e-02 -3.50e-01 3.55e-01
PI-3K cascade:FGFR2 13 3.01e-02 -3.47e-01 2.89e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.64e-03 -3.47e-01 7.14e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.64e-03 -3.47e-01 7.14e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 2.64e-03 -3.47e-01 7.14e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 2.64e-03 -3.47e-01 7.14e-02
Organic anion transporters 7 1.14e-01 3.45e-01 4.51e-01
NF-kB is activated and signals survival 12 3.92e-02 3.44e-01 3.12e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.84e-01 -3.43e-01 5.46e-01
Phenylalanine and tyrosine metabolism 9 7.50e-02 3.43e-01 3.98e-01
Lysosphingolipid and LPA receptors 11 4.97e-02 3.42e-01 3.42e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 10 6.22e-02 3.41e-01 3.66e-01
IkBA variant leads to EDA-ID 7 1.19e-01 3.40e-01 4.59e-01
Phospholipase C-mediated cascade; FGFR4 6 1.49e-01 3.40e-01 5.00e-01
Defective GALNT12 causes CRCS1 8 9.64e-02 3.39e-01 4.37e-01
Apoptotic cleavage of cell adhesion proteins 8 9.69e-02 -3.39e-01 4.37e-01
MET activates RAP1 and RAC1 10 6.36e-02 -3.39e-01 3.71e-01
Regulation of CDH11 mRNA translation by microRNAs 8 9.74e-02 -3.38e-01 4.37e-01
Regulation of NPAS4 mRNA translation 8 9.74e-02 -3.38e-01 4.37e-01
Signaling by activated point mutants of FGFR1 5 1.91e-01 3.37e-01 5.53e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 1.67e-03 -3.37e-01 5.63e-02
LTC4-CYSLTR mediated IL4 production 5 1.92e-01 -3.37e-01 5.53e-01
RAS signaling downstream of NF1 loss-of-function variants 7 1.23e-01 -3.37e-01 4.62e-01
Regulation of NPAS4 gene expression 11 5.45e-02 -3.35e-01 3.55e-01
Maturation of spike protein 9683686 5 1.97e-01 3.33e-01 5.58e-01
Ethanol oxidation 6 1.59e-01 3.32e-01 5.10e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 4.69e-02 -3.31e-01 3.33e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 1.60e-01 -3.31e-01 5.10e-01
Scavenging by Class F Receptors 5 2.00e-01 -3.31e-01 5.58e-01
Plasma lipoprotein remodeling 18 1.53e-02 3.30e-01 2.01e-01
Regulation of NFE2L2 gene expression 8 1.06e-01 3.30e-01 4.44e-01
CLEC7A (Dectin-1) induces NFAT activation 11 6.10e-02 -3.26e-01 3.62e-01
PI-3K cascade:FGFR3 10 7.49e-02 -3.25e-01 3.98e-01
IRAK4 deficiency (TLR2/4) 15 2.93e-02 -3.25e-01 2.84e-01
Maturation of nucleoprotein 9694631 15 3.03e-02 -3.23e-01 2.89e-01
Reversible hydration of carbon dioxide 8 1.14e-01 3.23e-01 4.51e-01
Physiological factors 9 9.41e-02 -3.22e-01 4.37e-01
Activated NTRK2 signals through FRS2 and FRS3 8 1.14e-01 -3.22e-01 4.51e-01
IFNG signaling activates MAPKs 8 1.15e-01 -3.22e-01 4.51e-01
Transport of RCbl within the body 8 1.16e-01 3.21e-01 4.52e-01
Interleukin-21 signaling 9 9.57e-02 -3.21e-01 4.37e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 3.85e-04 -3.20e-01 2.11e-02
Diseases of DNA Double-Strand Break Repair 41 3.85e-04 -3.20e-01 2.11e-02
Signaling by FGFR4 in disease 11 6.73e-02 -3.19e-01 3.80e-01
HDR through Single Strand Annealing (SSA) 37 8.11e-04 -3.18e-01 3.54e-02
Presynaptic phase of homologous DNA pairing and strand exchange 40 5.04e-04 -3.18e-01 2.55e-02
Sulfur amino acid metabolism 22 9.87e-03 3.18e-01 1.79e-01
Formation of apoptosome 11 6.91e-02 -3.17e-01 3.84e-01
Regulation of the apoptosome activity 11 6.91e-02 -3.17e-01 3.84e-01
CHL1 interactions 8 1.24e-01 -3.14e-01 4.66e-01
MAPK1 (ERK2) activation 8 1.25e-01 -3.13e-01 4.67e-01
Regulation of TLR by endogenous ligand 15 3.61e-02 -3.13e-01 3.01e-01
WNT mediated activation of DVL 8 1.26e-01 3.12e-01 4.67e-01
Lipophagy 7 1.52e-01 -3.12e-01 5.02e-01
RHOBTB1 GTPase cycle 23 9.55e-03 -3.12e-01 1.76e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 7.36e-02 3.12e-01 3.94e-01
NFE2L2 regulating ER-stress associated genes 5 2.29e-01 3.11e-01 5.97e-01
Phospholipase C-mediated cascade; FGFR3 5 2.31e-01 3.09e-01 5.99e-01
Regulation of RUNX1 Expression and Activity 18 2.36e-02 -3.08e-01 2.59e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 3.56e-02 -3.03e-01 3.01e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 5.93e-02 -3.02e-01 3.55e-01
Bicarbonate transporters 9 1.18e-01 -3.01e-01 4.59e-01
Signaling by FLT3 fusion proteins 18 2.74e-02 -3.00e-01 2.76e-01
MAPK3 (ERK1) activation 9 1.19e-01 -3.00e-01 4.59e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 1.72e-01 2.98e-01 5.31e-01
Eicosanoids 6 2.07e-01 -2.97e-01 5.63e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.75e-01 -2.96e-01 5.35e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 4.03e-02 -2.96e-01 3.18e-01
Arachidonate production from DAG 5 2.54e-01 2.95e-01 6.27e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 1.17e-03 -2.93e-01 4.45e-02
Digestion 5 2.57e-01 2.93e-01 6.30e-01
HDR through MMEJ (alt-NHEJ) 12 8.02e-02 -2.92e-01 4.11e-01
CS/DS degradation 9 1.31e-01 2.91e-01 4.77e-01
Negative regulation of MET activity 18 3.41e-02 -2.88e-01 2.99e-01
2-LTR circle formation 7 1.87e-01 -2.88e-01 5.48e-01
Homologous DNA Pairing and Strand Exchange 43 1.15e-03 -2.87e-01 4.45e-02
Heme degradation 10 1.19e-01 2.85e-01 4.59e-01
Displacement of DNA glycosylase by APEX1 9 1.40e-01 2.84e-01 4.89e-01
MyD88 deficiency (TLR2/4) 14 6.62e-02 -2.84e-01 3.76e-01
Regulation of PTEN localization 9 1.41e-01 -2.83e-01 4.90e-01
A tetrasaccharide linker sequence is required for GAG synthesis 16 4.97e-02 2.83e-01 3.42e-01
RHOT1 GTPase cycle 5 2.73e-01 -2.83e-01 6.42e-01
Alpha-protein kinase 1 signaling pathway 11 1.04e-01 -2.83e-01 4.42e-01
SUMOylation of immune response proteins 12 9.22e-02 2.81e-01 4.33e-01
Serotonin Neurotransmitter Release Cycle 15 6.07e-02 2.80e-01 3.61e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.26e-01 -2.80e-01 4.67e-01
CDH11 homotypic and heterotypic interactions 5 2.80e-01 2.79e-01 6.51e-01
Prolactin receptor signaling 11 1.10e-01 -2.78e-01 4.49e-01
Metabolism of amine-derived hormones 10 1.31e-01 2.76e-01 4.77e-01
RHOBTB2 GTPase cycle 23 2.20e-02 -2.76e-01 2.49e-01
G1/S-Specific Transcription 29 1.02e-02 -2.76e-01 1.79e-01
Signaling by FGFR1 in disease 32 7.01e-03 -2.75e-01 1.53e-01
RHOBTB3 ATPase cycle 10 1.33e-01 2.74e-01 4.81e-01
Acetylcholine regulates insulin secretion 9 1.56e-01 2.73e-01 5.07e-01
ISG15 antiviral mechanism 72 6.49e-05 -2.72e-01 4.98e-03
EGFR Transactivation by Gastrin 7 2.13e-01 -2.72e-01 5.72e-01
Androgen biosynthesis 5 2.98e-01 -2.69e-01 6.68e-01
VLDLR internalisation and degradation 16 6.31e-02 2.68e-01 3.71e-01
FGFR4 ligand binding and activation 5 2.99e-01 2.68e-01 6.68e-01
Regulation of TP53 Activity through Acetylation 29 1.25e-02 2.68e-01 1.86e-01
mRNA Editing 8 1.90e-01 -2.68e-01 5.52e-01
RUNX3 regulates NOTCH signaling 14 8.42e-02 2.67e-01 4.18e-01
Translesion synthesis by POLK 17 5.74e-02 -2.66e-01 3.55e-01
O-glycosylation of TSR domain-containing proteins 25 2.14e-02 2.66e-01 2.46e-01
Diseases of branched-chain amino acid catabolism 13 9.69e-02 -2.66e-01 4.37e-01
Integrin signaling 22 3.09e-02 2.66e-01 2.90e-01
Synaptic adhesion-like molecules 14 8.53e-02 2.66e-01 4.18e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.11e-01 2.65e-01 4.50e-01
Transport of connexons to the plasma membrane 12 1.11e-01 2.65e-01 4.50e-01
FGFR1 mutant receptor activation 25 2.24e-02 -2.64e-01 2.50e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 9.96e-02 -2.64e-01 4.39e-01
Elastic fibre formation 33 8.78e-03 2.64e-01 1.72e-01
PKA activation in glucagon signalling 14 8.80e-02 2.63e-01 4.26e-01
FGFR1 ligand binding and activation 10 1.50e-01 2.63e-01 5.00e-01
Platelet sensitization by LDL 16 6.85e-02 -2.63e-01 3.84e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.80e-02 -2.63e-01 2.22e-01
Nef Mediated CD4 Down-regulation 9 1.72e-01 2.63e-01 5.31e-01
Integration of provirus 9 1.74e-01 -2.61e-01 5.35e-01
Beta-oxidation of pristanoyl-CoA 9 1.75e-01 -2.61e-01 5.35e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 2.69e-01 -2.61e-01 6.36e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 1.04e-01 2.61e-01 4.42e-01
Interleukin-1 processing 8 2.02e-01 2.61e-01 5.58e-01
Maturation of nucleoprotein 9683610 11 1.35e-01 -2.60e-01 4.81e-01
Cargo concentration in the ER 31 1.21e-02 -2.60e-01 1.86e-01
Adenylate cyclase inhibitory pathway 11 1.35e-01 2.60e-01 4.81e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.79e-01 2.59e-01 5.39e-01
Signaling by MAPK mutants 6 2.72e-01 2.59e-01 6.42e-01
Regulation of BACH1 activity 11 1.38e-01 -2.58e-01 4.87e-01
Metalloprotease DUBs 20 4.57e-02 -2.58e-01 3.28e-01
Cleavage of the damaged purine 21 4.07e-02 2.58e-01 3.18e-01
Depurination 21 4.07e-02 2.58e-01 3.18e-01
Recognition and association of DNA glycosylase with site containing an affected purine 21 4.07e-02 2.58e-01 3.18e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 1.81e-01 2.57e-01 5.43e-01
Maturation of protein 3a 9683673 9 1.84e-01 -2.56e-01 5.46e-01
Maturation of protein 3a 9694719 9 1.84e-01 -2.56e-01 5.46e-01
Formation of definitive endoderm 8 2.11e-01 -2.56e-01 5.70e-01
Interleukin-27 signaling 11 1.42e-01 -2.55e-01 4.92e-01
Nef Mediated CD8 Down-regulation 7 2.42e-01 2.55e-01 6.16e-01
Apoptosis induced DNA fragmentation 10 1.63e-01 -2.55e-01 5.11e-01
EPHB-mediated forward signaling 38 6.67e-03 -2.54e-01 1.49e-01
Translesion synthesis by POLI 17 6.99e-02 -2.54e-01 3.84e-01
Cellular response to mitochondrial stress 9 1.90e-01 -2.52e-01 5.52e-01
Signaling by KIT in disease 20 5.08e-02 -2.52e-01 3.42e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 5.08e-02 -2.52e-01 3.42e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 8.19e-02 -2.51e-01 4.15e-01
PI-3K cascade:FGFR4 11 1.50e-01 -2.51e-01 5.00e-01
Reelin signalling pathway 5 3.33e-01 -2.50e-01 6.92e-01
PI3K events in ERBB4 signaling 6 2.90e-01 -2.50e-01 6.61e-01
Tryptophan catabolism 12 1.34e-01 -2.50e-01 4.81e-01
Nicotinamide salvaging 15 9.51e-02 -2.49e-01 4.37e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.92e-01 -2.49e-01 6.63e-01
Diseases of DNA repair 50 2.37e-03 -2.48e-01 7.14e-02
Biosynthesis of E-series 18(S)-resolvins 5 3.36e-01 2.48e-01 6.95e-01
RUNX1 regulates estrogen receptor mediated transcription 6 2.93e-01 -2.48e-01 6.64e-01
Transport and synthesis of PAPS 6 2.95e-01 -2.47e-01 6.66e-01
RHOBTB GTPase Cycle 35 1.17e-02 -2.46e-01 1.86e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 90 5.38e-05 -2.46e-01 4.70e-03
Amplification of signal from the kinetochores 90 5.38e-05 -2.46e-01 4.70e-03
FGFR1b ligand binding and activation 5 3.41e-01 2.46e-01 7.00e-01
MECP2 regulates neuronal receptors and channels 13 1.25e-01 -2.46e-01 4.66e-01
Nitric oxide stimulates guanylate cyclase 15 9.92e-02 2.46e-01 4.39e-01
Glycosphingolipid transport 7 2.60e-01 2.46e-01 6.32e-01
Signaling by NTRK2 (TRKB) 20 5.72e-02 -2.46e-01 3.55e-01
Mucopolysaccharidoses 11 1.60e-01 2.45e-01 5.10e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 2.06e-01 -2.43e-01 5.63e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 3.47e-01 -2.43e-01 7.00e-01
Pyrimidine salvage 10 1.85e-01 2.42e-01 5.47e-01
Glycerophospholipid catabolism 6 3.06e-01 2.41e-01 6.76e-01
Presynaptic depolarization and calcium channel opening 8 2.37e-01 2.41e-01 6.10e-01
Chondroitin sulfate/dermatan sulfate metabolism 37 1.12e-02 2.41e-01 1.83e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 2.70e-01 -2.41e-01 6.39e-01
Voltage gated Potassium channels 26 3.38e-02 2.40e-01 2.99e-01
DNA methylation 18 7.76e-02 2.40e-01 4.05e-01
AKT phosphorylates targets in the nucleus 9 2.13e-01 2.40e-01 5.72e-01
N-Glycan antennae elongation 12 1.51e-01 -2.40e-01 5.00e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.29e-02 -2.40e-01 1.86e-01
Germ layer formation at gastrulation 9 2.14e-01 -2.39e-01 5.73e-01
Incretin synthesis, secretion, and inactivation 14 1.22e-01 -2.39e-01 4.62e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.22e-01 -2.39e-01 4.62e-01
HS-GAG degradation 18 7.96e-02 2.39e-01 4.11e-01
Digestion and absorption 7 2.75e-01 2.38e-01 6.44e-01
eNOS activation 10 1.92e-01 -2.38e-01 5.53e-01
Defective B3GALTL causes PpS 24 4.39e-02 2.38e-01 3.24e-01
Resolution of Sister Chromatid Cohesion 115 1.16e-05 -2.37e-01 1.48e-03
Regulation of innate immune responses to cytosolic DNA 14 1.25e-01 2.37e-01 4.67e-01
Blood group systems biosynthesis 16 1.02e-01 2.36e-01 4.39e-01
MASTL Facilitates Mitotic Progression 10 1.96e-01 -2.36e-01 5.58e-01
Biosynthesis of DHA-derived SPMs 13 1.41e-01 2.36e-01 4.90e-01
Formation of annular gap junctions 10 1.96e-01 2.36e-01 5.58e-01
FGFR1c ligand binding and activation 8 2.48e-01 2.36e-01 6.25e-01
G0 and Early G1 27 3.40e-02 -2.36e-01 2.99e-01
NFE2L2 regulating tumorigenic genes 11 1.78e-01 2.34e-01 5.39e-01
Activation of Matrix Metalloproteinases 20 6.95e-02 2.34e-01 3.84e-01
NFE2L2 regulates pentose phosphate pathway genes 8 2.51e-01 2.34e-01 6.27e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 8.54e-02 2.34e-01 4.18e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 2.01e-01 -2.34e-01 5.58e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.69e-02 -2.33e-01 2.73e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 2.86e-01 2.33e-01 6.57e-01
Activation of ATR in response to replication stress 37 1.43e-02 -2.33e-01 1.98e-01
Base-Excision Repair, AP Site Formation 28 3.31e-02 2.33e-01 2.99e-01
E2F mediated regulation of DNA replication 22 5.92e-02 -2.32e-01 3.55e-01
Calcineurin activates NFAT 9 2.28e-01 -2.32e-01 5.97e-01
Urea cycle 6 3.26e-01 2.32e-01 6.86e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 2.82e-02 -2.32e-01 2.77e-01
Mitotic Spindle Checkpoint 107 3.92e-05 -2.30e-01 4.43e-03
Translesion synthesis by REV1 16 1.12e-01 -2.29e-01 4.50e-01
Initiation of Nuclear Envelope (NE) Reformation 19 8.44e-02 -2.29e-01 4.18e-01
Nicotinate metabolism 26 4.39e-02 -2.28e-01 3.24e-01
Assembly of active LPL and LIPC lipase complexes 10 2.12e-01 2.28e-01 5.72e-01
Nef and signal transduction 8 2.64e-01 -2.28e-01 6.34e-01
Plasma lipoprotein clearance 33 2.40e-02 2.27e-01 2.61e-01
Nephrin family interactions 19 8.81e-02 -2.26e-01 4.26e-01
Retrograde neurotrophin signalling 12 1.76e-01 2.26e-01 5.37e-01
cGMP effects 12 1.77e-01 2.25e-01 5.37e-01
Signaling by FGFR3 in disease 14 1.45e-01 -2.25e-01 4.96e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 3.03e-01 -2.25e-01 6.74e-01
Gap junction degradation 11 1.97e-01 2.24e-01 5.58e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.86e-01 2.24e-01 7.36e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 1.47e-01 -2.24e-01 5.00e-01
Role of ABL in ROBO-SLIT signaling 6 3.43e-01 -2.24e-01 7.00e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 7.00e-02 2.23e-01 3.84e-01
Downregulation of ERBB4 signaling 8 2.80e-01 -2.21e-01 6.51e-01
P2Y receptors 10 2.27e-01 -2.21e-01 5.97e-01
Endosomal/Vacuolar pathway 11 2.06e-01 -2.20e-01 5.63e-01
Interleukin-12 family signaling 53 5.59e-03 -2.20e-01 1.34e-01
Interleukin-9 signaling 8 2.82e-01 -2.20e-01 6.54e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 4.44e-03 2.20e-01 1.12e-01
Scavenging by Class A Receptors 10 2.29e-01 -2.20e-01 5.97e-01
Formation of the nephric duct 8 2.83e-01 -2.19e-01 6.54e-01
Axonal growth inhibition (RHOA activation) 7 3.15e-01 2.19e-01 6.76e-01
p75NTR regulates axonogenesis 7 3.15e-01 2.19e-01 6.76e-01
Mitochondrial unfolded protein response (UPRmt) 17 1.18e-01 2.19e-01 4.59e-01
MAPK6/MAPK4 signaling 69 1.70e-03 -2.18e-01 5.63e-02
Loss of Function of SMAD2/3 in Cancer 7 3.17e-01 -2.18e-01 6.76e-01
Transcription of E2F targets under negative control by DREAM complex 19 1.00e-01 -2.18e-01 4.39e-01
Downstream signaling of activated FGFR2 20 9.24e-02 -2.17e-01 4.33e-01
CD163 mediating an anti-inflammatory response 8 2.88e-01 2.17e-01 6.59e-01
Glutathione synthesis and recycling 10 2.37e-01 -2.16e-01 6.10e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 1.04e-01 -2.16e-01 4.42e-01
CD28 dependent Vav1 pathway 12 1.96e-01 -2.16e-01 5.58e-01
SUMOylation of DNA methylation proteins 16 1.35e-01 2.16e-01 4.81e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.62e-01 -2.16e-01 5.11e-01
Hyaluronan metabolism 15 1.49e-01 2.15e-01 5.00e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 2.18e-01 2.15e-01 5.83e-01
Nephron development 5 4.06e-01 2.14e-01 7.45e-01
Synthesis, secretion, and deacylation of Ghrelin 11 2.19e-01 -2.14e-01 5.84e-01
Interleukin-12 signaling 44 1.40e-02 -2.14e-01 1.96e-01
Signaling by FLT3 ITD and TKD mutants 15 1.52e-01 -2.14e-01 5.02e-01
Defective CFTR causes cystic fibrosis 47 1.14e-02 -2.13e-01 1.85e-01
Carboxyterminal post-translational modifications of tubulin 33 3.41e-02 2.13e-01 2.99e-01
Interleukin-35 Signalling 12 2.01e-01 -2.13e-01 5.58e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 1.84e-01 2.13e-01 5.46e-01
APOBEC3G mediated resistance to HIV-1 infection 5 4.11e-01 2.12e-01 7.46e-01
TYSND1 cleaves peroxisomal proteins 7 3.32e-01 -2.12e-01 6.92e-01
RND1 GTPase cycle 36 2.83e-02 -2.11e-01 2.78e-01
Post-chaperonin tubulin folding pathway 18 1.22e-01 2.10e-01 4.62e-01
Ribavirin ADME 11 2.30e-01 -2.09e-01 5.97e-01
Defective B4GALT7 causes EDS, progeroid type 10 2.54e-01 2.09e-01 6.27e-01
Signaling by CSF3 (G-CSF) 29 5.22e-02 -2.08e-01 3.45e-01
NFE2L2 regulating MDR associated enzymes 8 3.08e-01 2.08e-01 6.76e-01
CD28 dependent PI3K/Akt signaling 22 9.22e-02 2.07e-01 4.33e-01
Expression and translocation of olfactory receptors 49 1.20e-02 -2.07e-01 1.86e-01
tRNA modification in the mitochondrion 9 2.82e-01 2.07e-01 6.54e-01
NrCAM interactions 6 3.81e-01 2.07e-01 7.33e-01
Serine biosynthesis 8 3.15e-01 -2.05e-01 6.76e-01
p75NTR signals via NF-kB 15 1.70e-01 2.05e-01 5.28e-01
Defective B3GAT3 causes JDSSDHD 10 2.62e-01 2.05e-01 6.33e-01
PI3K/AKT activation 8 3.17e-01 -2.04e-01 6.76e-01
Diseases associated with O-glycosylation of proteins 46 1.65e-02 2.04e-01 2.11e-01
IKK complex recruitment mediated by RIP1 23 9.03e-02 -2.04e-01 4.30e-01
Calnexin/calreticulin cycle 26 7.20e-02 -2.04e-01 3.92e-01
Molecules associated with elastic fibres 26 7.24e-02 2.04e-01 3.92e-01
RIP-mediated NFkB activation via ZBP1 17 1.48e-01 2.03e-01 5.00e-01
Nucleotide-like (purinergic) receptors 14 1.89e-01 -2.03e-01 5.52e-01
DNA Damage Bypass 47 1.63e-02 -2.02e-01 2.11e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 5.57e-02 -2.02e-01 3.55e-01
FOXO-mediated transcription of cell death genes 16 1.63e-01 2.01e-01 5.13e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.11e-01 -2.01e-01 4.49e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.11e-01 -2.01e-01 4.49e-01
Signaling by MST1 5 4.37e-01 2.01e-01 7.52e-01
PINK1-PRKN Mediated Mitophagy 31 5.32e-02 -2.01e-01 3.48e-01
Biosynthesis of EPA-derived SPMs 6 3.96e-01 2.00e-01 7.43e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 2.49e-02 -2.00e-01 2.63e-01
FRS-mediated FGFR2 signaling 15 1.80e-01 -2.00e-01 5.42e-01
Separation of Sister Chromatids 167 8.53e-06 -2.00e-01 1.23e-03
Phosphate bond hydrolysis by NUDT proteins 7 3.61e-01 -2.00e-01 7.18e-01
TNFs bind their physiological receptors 25 8.43e-02 1.99e-01 4.18e-01
Cell Cycle Checkpoints 245 7.65e-08 -1.99e-01 3.59e-05
Antiviral mechanism by IFN-stimulated genes 140 4.67e-05 -1.99e-01 4.67e-03
Golgi Associated Vesicle Biogenesis 55 1.07e-02 -1.99e-01 1.82e-01
Tight junction interactions 17 1.56e-01 1.99e-01 5.07e-01
Cleavage of the damaged pyrimidine 26 8.01e-02 1.98e-01 4.11e-01
Depyrimidination 26 8.01e-02 1.98e-01 4.11e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 8.01e-02 1.98e-01 4.11e-01
Biosynthesis of Lipoxins (LX) 6 4.02e-01 1.98e-01 7.45e-01
Neurexins and neuroligins 35 4.30e-02 1.98e-01 3.24e-01
RAF activation 32 5.31e-02 -1.98e-01 3.48e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 3.65e-01 1.98e-01 7.24e-01
NCAM1 interactions 26 8.14e-02 1.97e-01 4.14e-01
Transcriptional Regulation by NPAS4 27 7.60e-02 -1.97e-01 4.01e-01
Prolonged ERK activation events 13 2.19e-01 -1.97e-01 5.85e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 3.68e-01 -1.97e-01 7.26e-01
Negative regulation of NOTCH4 signaling 44 2.44e-02 -1.96e-01 2.61e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.04e-01 1.96e-01 4.42e-01
Insulin processing 19 1.40e-01 -1.96e-01 4.89e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 4.06e-01 1.96e-01 7.45e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 4.06e-01 1.96e-01 7.45e-01
p130Cas linkage to MAPK signaling for integrins 11 2.62e-01 1.95e-01 6.32e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 2.06e-01 1.95e-01 5.63e-01
Mismatch Repair 15 1.91e-01 -1.95e-01 5.53e-01
EML4 and NUDC in mitotic spindle formation 106 5.36e-04 -1.95e-01 2.64e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 63 7.56e-03 -1.95e-01 1.56e-01
Respiratory Syncytial Virus Infection Pathway 97 9.26e-04 -1.95e-01 3.87e-02
Deadenylation-dependent mRNA decay 50 1.74e-02 -1.94e-01 2.18e-01
ERKs are inactivated 13 2.25e-01 1.94e-01 5.93e-01
Interleukin-2 signaling 11 2.66e-01 1.94e-01 6.34e-01
Synthesis of IP3 and IP4 in the cytosol 22 1.16e-01 1.93e-01 4.54e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 1.80e-02 1.93e-01 2.22e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 9.48e-02 1.93e-01 4.37e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.35e-01 1.93e-01 4.81e-01
PKA activation 15 1.97e-01 1.93e-01 5.58e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 3.46e-01 -1.92e-01 7.00e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 1.00e-02 -1.92e-01 1.79e-01
Signal attenuation 9 3.18e-01 1.92e-01 6.76e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 9.54e-03 -1.92e-01 1.76e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 6.89e-02 1.92e-01 3.84e-01
FLT3 signaling in disease 27 8.46e-02 -1.92e-01 4.18e-01
Relaxin receptors 5 4.59e-01 1.91e-01 7.70e-01
Fatty acids 6 4.18e-01 -1.91e-01 7.46e-01
G2/M DNA damage checkpoint 66 7.35e-03 -1.91e-01 1.55e-01
Estrogen-stimulated signaling through PRKCZ 6 4.20e-01 -1.90e-01 7.46e-01
Mitotic G1 phase and G1/S transition 138 1.32e-04 -1.89e-01 9.36e-03
Inactivation of CSF3 (G-CSF) signaling 24 1.11e-01 -1.88e-01 4.49e-01
Regulation of Apoptosis 40 4.04e-02 -1.87e-01 3.18e-01
Glyoxylate metabolism and glycine degradation 13 2.43e-01 1.87e-01 6.17e-01
G2/M Checkpoints 126 2.88e-04 -1.87e-01 1.73e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 10 3.06e-01 1.87e-01 6.76e-01
Mitotic Metaphase and Anaphase 211 2.87e-06 -1.87e-01 6.13e-04
Regulation of TP53 Activity through Phosphorylation 88 2.45e-03 -1.87e-01 7.14e-02
Orc1 removal from chromatin 58 1.41e-02 -1.86e-01 1.96e-01
Mitotic Anaphase 210 3.29e-06 -1.86e-01 6.32e-04
FOXO-mediated transcription of cell cycle genes 14 2.28e-01 -1.86e-01 5.97e-01
Metabolism of fat-soluble vitamins 26 1.00e-01 1.86e-01 4.39e-01
RNA Polymerase I Promoter Opening 17 1.84e-01 1.86e-01 5.46e-01
Gluconeogenesis 19 1.61e-01 1.86e-01 5.10e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 2.29e-01 -1.86e-01 5.97e-01
Cyclin D associated events in G1 47 2.78e-02 -1.85e-01 2.76e-01
G1 Phase 47 2.78e-02 -1.85e-01 2.76e-01
Lewis blood group biosynthesis 13 2.48e-01 1.85e-01 6.24e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 1.09e-01 -1.85e-01 4.49e-01
XBP1(S) activates chaperone genes 44 3.43e-02 1.84e-01 2.99e-01
RUNX2 regulates genes involved in cell migration 6 4.34e-01 1.84e-01 7.51e-01
ERBB2 Activates PTK6 Signaling 8 3.69e-01 1.84e-01 7.26e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 3.41e-01 -1.83e-01 7.00e-01
Common Pathway of Fibrin Clot Formation 13 2.52e-01 1.83e-01 6.27e-01
Noncanonical activation of NOTCH3 8 3.70e-01 -1.83e-01 7.26e-01
Non-integrin membrane-ECM interactions 46 3.17e-02 1.83e-01 2.96e-01
Dectin-2 family 18 1.79e-01 -1.83e-01 5.39e-01
Pausing and recovery of Tat-mediated HIV elongation 30 8.34e-02 1.83e-01 4.18e-01
Tat-mediated HIV elongation arrest and recovery 30 8.34e-02 1.83e-01 4.18e-01
Degradation of GLI2 by the proteasome 45 3.44e-02 -1.82e-01 2.99e-01
GLI3 is processed to GLI3R by the proteasome 45 3.44e-02 -1.82e-01 2.99e-01
Cytosolic tRNA aminoacylation 24 1.23e-01 -1.82e-01 4.62e-01
Gap junction trafficking 27 1.02e-01 1.82e-01 4.39e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 4.82e-01 -1.82e-01 7.84e-01
Activation of RAC1 downstream of NMDARs 7 4.05e-01 1.82e-01 7.45e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 2.39e-01 -1.82e-01 6.13e-01
Apoptotic factor-mediated response 19 1.71e-01 -1.81e-01 5.31e-01
Downstream signaling of activated FGFR3 17 1.96e-01 -1.81e-01 5.58e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.10e-01 1.81e-01 4.49e-01
Signaling by Hippo 18 1.85e-01 -1.81e-01 5.47e-01
Recognition of DNA damage by PCNA-containing replication complex 30 8.73e-02 -1.80e-01 4.25e-01
BBSome-mediated cargo-targeting to cilium 23 1.35e-01 -1.80e-01 4.81e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.28e-02 -1.80e-01 1.86e-01
Retinoid metabolism and transport 23 1.38e-01 1.79e-01 4.87e-01
Metabolism of porphyrins 22 1.47e-01 1.79e-01 5.00e-01
Regulation of KIT signaling 15 2.31e-01 -1.79e-01 5.99e-01
Trafficking and processing of endosomal TLR 13 2.65e-01 -1.78e-01 6.34e-01
Depolymerization of the Nuclear Lamina 15 2.32e-01 -1.78e-01 6.00e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 3.29e-01 -1.78e-01 6.92e-01
Triglyceride catabolism 15 2.33e-01 -1.78e-01 6.01e-01
Pregnenolone biosynthesis 10 3.31e-01 1.77e-01 6.92e-01
Histidine catabolism 7 4.17e-01 -1.77e-01 7.46e-01
Cardiogenesis 13 2.69e-01 1.77e-01 6.36e-01
Interferon Signaling 237 2.75e-06 -1.77e-01 6.13e-04
AKT phosphorylates targets in the cytosol 14 2.52e-01 1.77e-01 6.27e-01
S Phase 150 1.87e-04 -1.77e-01 1.29e-02
Phase 2 - plateau phase 12 2.90e-01 -1.76e-01 6.62e-01
Degradation of GLI1 by the proteasome 46 3.85e-02 -1.76e-01 3.10e-01
Early SARS-CoV-2 Infection Events 30 9.51e-02 -1.76e-01 4.37e-01
Regulation of RAS by GAPs 55 2.39e-02 -1.76e-01 2.61e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.02e-01 -1.75e-01 4.39e-01
Estrogen biosynthesis 5 4.97e-01 -1.75e-01 7.93e-01
Constitutive Signaling by EGFRvIII 14 2.56e-01 -1.75e-01 6.29e-01
Signaling by EGFRvIII in Cancer 14 2.56e-01 -1.75e-01 6.29e-01
Pyroptosis 24 1.38e-01 -1.75e-01 4.87e-01
Effects of PIP2 hydrolysis 24 1.38e-01 1.75e-01 4.87e-01
Packaging Of Telomere Ends 18 1.99e-01 1.75e-01 5.58e-01
ER Quality Control Compartment (ERQC) 21 1.68e-01 -1.74e-01 5.23e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 6.77e-02 -1.74e-01 3.81e-01
Aryl hydrocarbon receptor signalling 6 4.62e-01 -1.73e-01 7.71e-01
p75NTR recruits signalling complexes 12 2.99e-01 1.73e-01 6.68e-01
Apoptotic execution phase 46 4.25e-02 -1.73e-01 3.24e-01
ABC transporter disorders 59 2.18e-02 -1.73e-01 2.49e-01
Protein ubiquitination 71 1.21e-02 -1.72e-01 1.86e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 2.65e-01 -1.72e-01 6.34e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.44e-01 -1.72e-01 4.96e-01
Collagen biosynthesis and modifying enzymes 45 4.57e-02 1.72e-01 3.28e-01
Stabilization of p53 43 5.16e-02 -1.72e-01 3.45e-01
Long-term potentiation 14 2.66e-01 1.72e-01 6.34e-01
G1/S Transition 120 1.18e-03 -1.71e-01 4.45e-02
DARPP-32 events 22 1.64e-01 -1.71e-01 5.14e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 6.49e-02 -1.71e-01 3.73e-01
p53-Independent DNA Damage Response 39 6.49e-02 -1.71e-01 3.73e-01
p53-Independent G1/S DNA damage checkpoint 39 6.49e-02 -1.71e-01 3.73e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 2.87e-01 1.71e-01 6.57e-01
Processing of Intronless Pre-mRNAs 20 1.87e-01 -1.71e-01 5.48e-01
LGI-ADAM interactions 9 3.76e-01 1.71e-01 7.30e-01
Cargo trafficking to the periciliary membrane 48 4.11e-02 -1.70e-01 3.18e-01
Nucleotide biosynthesis 12 3.07e-01 1.70e-01 6.76e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.54e-01 -1.70e-01 6.27e-01
Downregulation of ERBB2:ERBB3 signaling 12 3.08e-01 1.70e-01 6.76e-01
ECM proteoglycans 45 4.86e-02 1.70e-01 3.39e-01
Proteasome assembly 50 3.79e-02 -1.70e-01 3.08e-01
Hh mutants are degraded by ERAD 42 5.74e-02 -1.69e-01 3.55e-01
SCF-beta-TrCP mediated degradation of Emi1 42 5.76e-02 -1.69e-01 3.55e-01
Regulation of ornithine decarboxylase (ODC) 38 7.13e-02 -1.69e-01 3.90e-01
Erythropoietin activates STAT5 6 4.74e-01 -1.69e-01 7.79e-01
Early Phase of HIV Life Cycle 14 2.75e-01 -1.69e-01 6.44e-01
Activation of the pre-replicative complex 32 9.95e-02 -1.68e-01 4.39e-01
Cell-extracellular matrix interactions 15 2.60e-01 1.68e-01 6.32e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 1.54e-01 -1.68e-01 5.04e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 2.60e-01 -1.68e-01 6.32e-01
Downstream signaling events of B Cell Receptor (BCR) 68 1.67e-02 -1.68e-01 2.11e-01
Mitotic Prometaphase 192 6.07e-05 -1.68e-01 4.86e-03
GABA synthesis, release, reuptake and degradation 12 3.14e-01 1.68e-01 6.76e-01
Vpu mediated degradation of CD4 39 7.01e-02 -1.68e-01 3.84e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 4.13e-01 1.67e-01 7.46e-01
Chondroitin sulfate biosynthesis 12 3.17e-01 1.67e-01 6.76e-01
Detoxification of Reactive Oxygen Species 30 1.14e-01 -1.67e-01 4.51e-01
APC-Cdc20 mediated degradation of Nek2A 26 1.43e-01 -1.66e-01 4.93e-01
CaMK IV-mediated phosphorylation of CREB 8 4.17e-01 -1.66e-01 7.46e-01
APC/C:Cdc20 mediated degradation of Securin 55 3.35e-02 -1.66e-01 2.99e-01
GAB1 signalosome 14 2.84e-01 -1.65e-01 6.55e-01
Ub-specific processing proteases 153 4.26e-04 -1.65e-01 2.21e-02
E3 ubiquitin ligases ubiquitinate target proteins 51 4.17e-02 -1.65e-01 3.22e-01
Suppression of apoptosis 7 4.50e-01 1.65e-01 7.64e-01
Degradation of AXIN 42 6.55e-02 -1.64e-01 3.76e-01
RHO GTPases Activate WASPs and WAVEs 35 9.31e-02 -1.64e-01 4.35e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 2.05e-01 -1.64e-01 5.63e-01
Regulation of APC/C activators between G1/S and early anaphase 68 1.98e-02 -1.63e-01 2.35e-01
Regulation of beta-cell development 21 1.95e-01 1.63e-01 5.58e-01
Frs2-mediated activation 11 3.48e-01 -1.63e-01 7.01e-01
Switching of origins to a post-replicative state 79 1.21e-02 -1.63e-01 1.86e-01
Tie2 Signaling 16 2.59e-01 -1.63e-01 6.31e-01
Activation of BH3-only proteins 29 1.29e-01 1.63e-01 4.76e-01
FGFR2 ligand binding and activation 9 3.98e-01 1.63e-01 7.45e-01
APC/C-mediated degradation of cell cycle proteins 75 1.50e-02 -1.62e-01 2.01e-01
Regulation of mitotic cell cycle 75 1.50e-02 -1.62e-01 2.01e-01
Uptake of dietary cobalamins into enterocytes 5 5.30e-01 1.62e-01 8.12e-01
Polo-like kinase mediated events 16 2.61e-01 -1.62e-01 6.32e-01
Extracellular matrix organization 213 4.57e-05 1.62e-01 4.67e-03
Collagen formation 63 2.63e-02 1.62e-01 2.70e-01
Assembly of collagen fibrils and other multimeric structures 41 7.33e-02 1.62e-01 3.94e-01
Response to metal ions 6 4.93e-01 -1.62e-01 7.90e-01
VxPx cargo-targeting to cilium 19 2.23e-01 -1.61e-01 5.89e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.47e-01 -1.61e-01 5.00e-01
Dopamine Neurotransmitter Release Cycle 20 2.12e-01 1.61e-01 5.72e-01
ABC transporters in lipid homeostasis 14 2.98e-01 1.61e-01 6.68e-01
PI5P Regulates TP53 Acetylation 8 4.31e-01 1.61e-01 7.50e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 1.01e-01 -1.60e-01 4.39e-01
Cellular hexose transport 14 2.99e-01 1.60e-01 6.68e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 4.58e-02 -1.60e-01 3.28e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.54e-01 -1.60e-01 6.27e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.54e-01 -1.60e-01 6.27e-01
Defective GALNT3 causes HFTC 8 4.35e-01 1.59e-01 7.51e-01
RHO GTPases Activate ROCKs 18 2.42e-01 -1.59e-01 6.16e-01
EGFR interacts with phospholipase C-gamma 6 4.99e-01 1.59e-01 7.93e-01
Activation of NF-kappaB in B cells 54 4.31e-02 -1.59e-01 3.24e-01
Synthesis of PIPs at the ER membrane 5 5.39e-01 -1.59e-01 8.19e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 4.79e-02 1.59e-01 3.37e-01
HIV elongation arrest and recovery 32 1.21e-01 1.59e-01 4.61e-01
Pausing and recovery of HIV elongation 32 1.21e-01 1.59e-01 4.61e-01
Gap junction trafficking and regulation 29 1.40e-01 1.58e-01 4.90e-01
Termination of translesion DNA synthesis 32 1.22e-01 -1.58e-01 4.62e-01
Ubiquinol biosynthesis 13 3.25e-01 1.58e-01 6.86e-01
Hedgehog ligand biogenesis 47 6.15e-02 -1.58e-01 3.63e-01
Sphingolipid de novo biosynthesis 34 1.12e-01 -1.57e-01 4.50e-01
Translation of Structural Proteins 9694635 55 4.39e-02 -1.57e-01 3.24e-01
RUNX1 regulates expression of components of tight junctions 5 5.44e-01 -1.57e-01 8.23e-01
IRE1alpha activates chaperones 46 6.57e-02 1.57e-01 3.76e-01
Protein-protein interactions at synapses 54 4.63e-02 1.57e-01 3.29e-01
SCF(Skp2)-mediated degradation of p27/p21 50 5.58e-02 -1.56e-01 3.55e-01
Replacement of protamines by nucleosomes in the male pronucleus 12 3.49e-01 1.56e-01 7.01e-01
RSV-host interactions 76 1.88e-02 -1.56e-01 2.27e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 8.43e-02 -1.56e-01 4.18e-01
Assembly and cell surface presentation of NMDA receptors 30 1.40e-01 1.56e-01 4.89e-01
Nuclear Receptor transcription pathway 38 9.78e-02 1.55e-01 4.38e-01
Transcriptional Regulation by E2F6 34 1.18e-01 -1.55e-01 4.59e-01
Metabolism of nitric oxide: NOS3 activation and regulation 13 3.35e-01 -1.54e-01 6.95e-01
Sialic acid metabolism 27 1.65e-01 -1.54e-01 5.16e-01
Antigen processing-Cross presentation 88 1.24e-02 -1.54e-01 1.86e-01
Sperm Motility And Taxes 6 5.14e-01 1.54e-01 8.02e-01
Keratan sulfate biosynthesis 19 2.46e-01 -1.54e-01 6.21e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 3.61e-02 -1.54e-01 3.01e-01
Ubiquitin-dependent degradation of Cyclin D 39 9.65e-02 -1.54e-01 4.37e-01
Olfactory Signaling Pathway 54 5.06e-02 -1.54e-01 3.42e-01
ER-Phagosome pathway 74 2.27e-02 -1.53e-01 2.52e-01
FLT3 signaling through SRC family kinases 6 5.16e-01 1.53e-01 8.03e-01
NS1 Mediated Effects on Host Pathways 40 9.44e-02 -1.53e-01 4.37e-01
Phase 3 - rapid repolarisation 7 4.84e-01 -1.53e-01 7.86e-01
Gap junction assembly 16 2.91e-01 1.52e-01 6.63e-01
Antimicrobial peptides 33 1.30e-01 1.52e-01 4.77e-01
Folding of actin by CCT/TriC 10 4.05e-01 -1.52e-01 7.45e-01
Complex III assembly 23 2.07e-01 1.52e-01 5.63e-01
Nonhomologous End-Joining (NHEJ) 40 9.66e-02 -1.52e-01 4.37e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 107 6.69e-03 -1.52e-01 1.49e-01
AMPK inhibits chREBP transcriptional activation activity 6 5.20e-01 -1.52e-01 8.05e-01
Synthesis of PIPs at the plasma membrane 52 5.85e-02 -1.52e-01 3.55e-01
Role of second messengers in netrin-1 signaling 6 5.20e-01 1.52e-01 8.05e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 1.99e-01 1.51e-01 5.58e-01
Signaling by FGFR3 32 1.38e-01 -1.51e-01 4.87e-01
WNT5A-dependent internalization of FZD4 13 3.47e-01 1.51e-01 7.00e-01
RA biosynthesis pathway 13 3.47e-01 1.51e-01 7.00e-01
PERK regulates gene expression 30 1.54e-01 -1.51e-01 5.03e-01
Abacavir ADME 5 5.60e-01 -1.51e-01 8.35e-01
Regulation of RUNX2 expression and activity 54 5.61e-02 -1.50e-01 3.55e-01
IRAK2 mediated activation of TAK1 complex 10 4.11e-01 -1.50e-01 7.46e-01
Glycogen synthesis 11 3.89e-01 -1.50e-01 7.36e-01
Defective Intrinsic Pathway for Apoptosis 24 2.04e-01 1.50e-01 5.61e-01
PECAM1 interactions 12 3.69e-01 -1.50e-01 7.26e-01
Paracetamol ADME 19 2.58e-01 1.50e-01 6.31e-01
Hh mutants abrogate ligand secretion 43 9.05e-02 -1.49e-01 4.30e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.34e-01 -1.49e-01 4.81e-01
Malate-aspartate shuttle 8 4.67e-01 1.48e-01 7.74e-01
Regulation of PTEN stability and activity 55 5.71e-02 -1.48e-01 3.55e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 2.51e-01 -1.48e-01 6.27e-01
Signaling by FGFR in disease 52 6.46e-02 -1.48e-01 3.73e-01
Synthesis of PE 12 3.75e-01 1.48e-01 7.30e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 3.75e-01 -1.48e-01 7.30e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.75e-01 1.48e-01 7.30e-01
DAP12 signaling 28 1.76e-01 -1.48e-01 5.37e-01
PKR-mediated signaling 67 3.65e-02 -1.48e-01 3.01e-01
Gamma-carboxylation of protein precursors 6 5.32e-01 1.47e-01 8.13e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 9.87e-02 -1.47e-01 4.39e-01
DAP12 interactions 39 1.12e-01 -1.47e-01 4.50e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 3.11e-01 -1.46e-01 6.76e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 1.19e-01 -1.46e-01 4.59e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 1.20e-01 -1.46e-01 4.60e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 5.36e-01 -1.46e-01 8.17e-01
Modulation by Mtb of host immune system 7 5.04e-01 -1.46e-01 7.97e-01
Processing of DNA double-strand break ends 69 3.66e-02 -1.46e-01 3.01e-01
Signaling by ERBB2 ECD mutants 15 3.30e-01 -1.45e-01 6.92e-01
Activation of RAS in B cells 5 5.74e-01 -1.45e-01 8.41e-01
Heme signaling 45 9.23e-02 -1.45e-01 4.33e-01
Cyclin E associated events during G1/S transition 73 3.22e-02 -1.45e-01 2.97e-01
FLT3 signaling by CBL mutants 7 5.07e-01 1.45e-01 7.99e-01
Regulated Necrosis 55 6.34e-02 -1.45e-01 3.71e-01
Downregulation of TGF-beta receptor signaling 26 2.02e-01 -1.45e-01 5.58e-01
FRS-mediated FGFR3 signaling 12 3.87e-01 -1.44e-01 7.36e-01
Vif-mediated degradation of APOBEC3G 41 1.10e-01 -1.44e-01 4.49e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 3.51e-01 1.44e-01 7.03e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 3.51e-01 1.44e-01 7.03e-01
Regulation of CDH11 function 9 4.55e-01 1.44e-01 7.69e-01
TRP channels 21 2.53e-01 1.44e-01 6.27e-01
Class I MHC mediated antigen processing & presentation 343 4.70e-06 -1.44e-01 8.21e-04
Downstream signaling of activated FGFR4 18 2.91e-01 -1.44e-01 6.63e-01
Potassium Channels 62 5.09e-02 1.43e-01 3.42e-01
TRIF-mediated programmed cell death 9 4.58e-01 -1.43e-01 7.70e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 7.75e-02 -1.43e-01 4.05e-01
Regulation of PTEN gene transcription 59 5.83e-02 1.43e-01 3.55e-01
Synthesis of DNA 108 1.06e-02 -1.42e-01 1.82e-01
Notch-HLH transcription pathway 28 1.92e-01 1.42e-01 5.53e-01
Collagen degradation 41 1.15e-01 1.42e-01 4.51e-01
CaM pathway 27 2.01e-01 1.42e-01 5.58e-01
Calmodulin induced events 27 2.01e-01 1.42e-01 5.58e-01
HS-GAG biosynthesis 19 2.84e-01 -1.42e-01 6.55e-01
Biosynthesis of maresins 5 5.83e-01 1.42e-01 8.44e-01
Diseases of carbohydrate metabolism 29 1.87e-01 1.42e-01 5.48e-01
Alpha-oxidation of phytanate 6 5.48e-01 -1.42e-01 8.27e-01
Apoptotic cleavage of cellular proteins 35 1.48e-01 -1.41e-01 5.00e-01
HDACs deacetylate histones 45 1.02e-01 1.41e-01 4.39e-01
Late SARS-CoV-2 Infection Events 63 5.32e-02 -1.41e-01 3.48e-01
Vitamin B2 (riboflavin) metabolism 6 5.51e-01 1.41e-01 8.27e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.50e-01 -1.41e-01 5.00e-01
RHO GTPases Activate Formins 127 6.35e-03 -1.40e-01 1.45e-01
Inactivation of CDC42 and RAC1 7 5.21e-01 -1.40e-01 8.05e-01
Defective C1GALT1C1 causes TNPS 9 4.67e-01 1.40e-01 7.74e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 2.68e-01 -1.40e-01 6.36e-01
PI3K events in ERBB2 signaling 11 4.23e-01 -1.40e-01 7.46e-01
Hyaluronan uptake and degradation 12 4.03e-01 1.39e-01 7.45e-01
Phosphorylation of the APC/C 20 2.81e-01 -1.39e-01 6.54e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 36 1.50e-01 -1.39e-01 5.00e-01
LDL clearance 18 3.10e-01 1.38e-01 6.76e-01
G alpha (z) signalling events 36 1.51e-01 1.38e-01 5.01e-01
Tandem pore domain potassium channels 5 5.93e-01 -1.38e-01 8.44e-01
Defective HLCS causes multiple carboxylase deficiency 7 5.27e-01 -1.38e-01 8.10e-01
Dissolution of Fibrin Clot 12 4.08e-01 1.38e-01 7.46e-01
APC truncation mutants have impaired AXIN binding 14 3.72e-01 -1.38e-01 7.26e-01
AXIN missense mutants destabilize the destruction complex 14 3.72e-01 -1.38e-01 7.26e-01
Signaling by AMER1 mutants 14 3.72e-01 -1.38e-01 7.26e-01
Signaling by APC mutants 14 3.72e-01 -1.38e-01 7.26e-01
Signaling by AXIN mutants 14 3.72e-01 -1.38e-01 7.26e-01
Truncations of AMER1 destabilize the destruction complex 14 3.72e-01 -1.38e-01 7.26e-01
Activation of the phototransduction cascade 8 5.00e-01 -1.38e-01 7.93e-01
Regulation of HSF1-mediated heat shock response 78 3.60e-02 -1.37e-01 3.01e-01
Defects in biotin (Btn) metabolism 8 5.02e-01 -1.37e-01 7.94e-01
Base Excision Repair 56 7.65e-02 1.37e-01 4.03e-01
Cell Cycle, Mitotic 487 2.55e-07 -1.36e-01 7.00e-05
NIK–>noncanonical NF-kB signaling 46 1.10e-01 -1.36e-01 4.49e-01
Initial triggering of complement 79 3.65e-02 1.36e-01 3.01e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 3.46e-01 -1.36e-01 7.00e-01
Formation of Incision Complex in GG-NER 43 1.23e-01 -1.36e-01 4.62e-01
VEGFR2 mediated cell proliferation 18 3.18e-01 -1.36e-01 6.76e-01
Diseases of mitotic cell cycle 38 1.47e-01 -1.36e-01 5.00e-01
Miro GTPase Cycle 8 5.07e-01 -1.36e-01 7.99e-01
PTK6 Regulates Cell Cycle 6 5.66e-01 1.35e-01 8.40e-01
RHOV GTPase cycle 36 1.61e-01 -1.35e-01 5.10e-01
Peptide hormone metabolism 53 8.90e-02 -1.35e-01 4.28e-01
Arachidonate metabolism 42 1.32e-01 1.34e-01 4.81e-01
Ketone body metabolism 8 5.11e-01 1.34e-01 8.01e-01
Mitophagy 38 1.52e-01 -1.34e-01 5.02e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.55e-01 1.34e-01 6.29e-01
Synthesis of Dolichyl-phosphate 6 5.70e-01 -1.34e-01 8.40e-01
PKA-mediated phosphorylation of CREB 17 3.39e-01 1.34e-01 7.00e-01
CDK-mediated phosphorylation and removal of Cdc6 60 7.31e-02 -1.34e-01 3.94e-01
Triglyceride metabolism 24 2.59e-01 -1.33e-01 6.32e-01
Downregulation of ERBB2 signaling 24 2.60e-01 1.33e-01 6.32e-01
Synthesis of Ketone Bodies 6 5.74e-01 1.33e-01 8.41e-01
HDR through Homologous Recombination (HRR) 68 5.86e-02 -1.33e-01 3.55e-01
M Phase 345 2.31e-05 -1.33e-01 2.77e-03
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 4.48e-01 1.32e-01 7.62e-01
Inhibition of DNA recombination at telomere 33 1.89e-01 1.32e-01 5.52e-01
Defective LFNG causes SCDO3 5 6.09e-01 -1.32e-01 8.53e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 3.33e-01 -1.32e-01 6.92e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 3.33e-01 -1.32e-01 6.92e-01
trans-Golgi Network Vesicle Budding 69 5.85e-02 -1.32e-01 3.55e-01
Azathioprine ADME 20 3.09e-01 -1.32e-01 6.76e-01
Mitochondrial RNA degradation 25 2.56e-01 -1.31e-01 6.29e-01
RND3 GTPase cycle 35 1.79e-01 -1.31e-01 5.39e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 9.54e-02 -1.31e-01 4.37e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 3.79e-01 1.31e-01 7.33e-01
Pyruvate metabolism 44 1.33e-01 -1.31e-01 4.81e-01
RMTs methylate histone arginines 35 1.80e-01 1.31e-01 5.42e-01
Creation of C4 and C2 activators 71 5.83e-02 1.30e-01 3.55e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 5.04e-02 -1.30e-01 3.42e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.79e-01 -1.30e-01 5.39e-01
COPI-independent Golgi-to-ER retrograde traffic 45 1.33e-01 -1.29e-01 4.81e-01
Activated NTRK2 signals through RAS 6 5.83e-01 -1.29e-01 8.44e-01
Activated NTRK3 signals through RAS 6 5.83e-01 -1.29e-01 8.44e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 5.02e-01 1.29e-01 7.94e-01
Transcriptional regulation of pluripotent stem cells 18 3.46e-01 -1.28e-01 7.00e-01
PI-3K cascade:FGFR1 13 4.24e-01 -1.28e-01 7.46e-01
PPARA activates gene expression 105 2.33e-02 -1.28e-01 2.58e-01
Signaling by ERBB2 in Cancer 21 3.10e-01 -1.28e-01 6.76e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.84e-01 -1.28e-01 5.46e-01
RUNX3 regulates p14-ARF 10 4.84e-01 1.28e-01 7.86e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.49e-01 1.28e-01 7.01e-01
Downstream TCR signaling 89 3.76e-02 -1.27e-01 3.08e-01
SHC-mediated cascade:FGFR1 13 4.26e-01 1.27e-01 7.46e-01
Activation of RAC1 11 4.65e-01 -1.27e-01 7.73e-01
Signaling by high-kinase activity BRAF mutants 33 2.07e-01 1.27e-01 5.63e-01
Ca2+ pathway 57 9.74e-02 -1.27e-01 4.37e-01
Activation of the AP-1 family of transcription factors 10 4.88e-01 -1.27e-01 7.88e-01
Cell Cycle 609 9.33e-08 -1.27e-01 3.59e-05
Glucagon signaling in metabolic regulation 26 2.65e-01 1.26e-01 6.34e-01
GPER1 signaling 38 1.78e-01 1.26e-01 5.39e-01
Classical antibody-mediated complement activation 69 6.99e-02 1.26e-01 3.84e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.29e-01 -1.26e-01 6.92e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 4.70e-01 -1.26e-01 7.76e-01
TRAF6 mediated NF-kB activation 23 2.99e-01 1.25e-01 6.68e-01
DNA Replication 128 1.46e-02 -1.25e-01 2.00e-01
Coenzyme A biosynthesis 7 5.67e-01 1.25e-01 8.40e-01
SUMOylation of DNA damage response and repair proteins 77 5.81e-02 -1.25e-01 3.55e-01
Sensory processing of sound by outer hair cells of the cochlea 40 1.72e-01 1.25e-01 5.31e-01
Interferon gamma signaling 87 4.42e-02 -1.25e-01 3.25e-01
Zinc transporters 12 4.55e-01 -1.25e-01 7.69e-01
Repression of WNT target genes 14 4.20e-01 1.25e-01 7.46e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.10e-01 -1.25e-01 4.49e-01
Intrinsic Pathway of Fibrin Clot Formation 15 4.04e-01 1.24e-01 7.45e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.36e-01 -1.24e-01 6.95e-01
TGFBR3 regulates TGF-beta signaling 8 5.43e-01 1.24e-01 8.23e-01
Fertilization 12 4.57e-01 1.24e-01 7.70e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 4.57e-01 1.24e-01 7.70e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 9.43e-02 -1.24e-01 4.37e-01
RNA Polymerase III Transcription Termination 22 3.16e-01 1.23e-01 6.76e-01
CD22 mediated BCR regulation 58 1.04e-01 1.23e-01 4.42e-01
Nuclear Envelope Breakdown 53 1.21e-01 -1.23e-01 4.62e-01
Resolution of D-Loop Structures 35 2.08e-01 -1.23e-01 5.63e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 4.45e-01 1.22e-01 7.61e-01
Kidney development 16 3.99e-01 -1.22e-01 7.45e-01
Degradation of the extracellular matrix 92 4.34e-02 1.22e-01 3.24e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 4.31e-01 1.22e-01 7.50e-01
Budding and maturation of HIV virion 26 2.83e-01 -1.22e-01 6.55e-01
HIV Transcription Initiation 45 1.59e-01 -1.21e-01 5.10e-01
RNA Polymerase II HIV Promoter Escape 45 1.59e-01 -1.21e-01 5.10e-01
RNA Polymerase II Promoter Escape 45 1.59e-01 -1.21e-01 5.10e-01
RNA Polymerase II Transcription Initiation 45 1.59e-01 -1.21e-01 5.10e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.59e-01 -1.21e-01 5.10e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.59e-01 -1.21e-01 5.10e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.50e-01 -1.21e-01 7.64e-01
Signaling by MET 67 8.67e-02 -1.21e-01 4.24e-01
RIPK1-mediated regulated necrosis 31 2.44e-01 -1.21e-01 6.19e-01
Regulation of necroptotic cell death 31 2.44e-01 -1.21e-01 6.19e-01
Synthesis of PG 8 5.54e-01 1.21e-01 8.30e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 5.77e-04 -1.21e-01 2.77e-02
Peroxisomal protein import 58 1.12e-01 -1.21e-01 4.50e-01
Suppression of phagosomal maturation 12 4.70e-01 -1.21e-01 7.76e-01
Deubiquitination 225 1.85e-03 -1.20e-01 5.81e-02
Syndecan interactions 23 3.17e-01 1.20e-01 6.76e-01
Acetylcholine binding and downstream events 5 6.42e-01 -1.20e-01 8.68e-01
Postsynaptic nicotinic acetylcholine receptors 5 6.42e-01 -1.20e-01 8.68e-01
Nuclear import of Rev protein 34 2.26e-01 -1.20e-01 5.96e-01
Uptake and function of anthrax toxins 10 5.13e-01 -1.20e-01 8.02e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 2.42e-01 -1.19e-01 6.16e-01
Signaling by EGFR 47 1.57e-01 -1.19e-01 5.08e-01
Nucleotide catabolism 29 2.66e-01 -1.19e-01 6.34e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 6.13e-01 -1.19e-01 8.54e-01
TGFBR1 KD Mutants in Cancer 6 6.13e-01 -1.19e-01 8.54e-01
HSF1-dependent transactivation 28 2.75e-01 1.19e-01 6.44e-01
RHOF GTPase cycle 38 2.04e-01 -1.19e-01 5.61e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 6.14e-01 1.19e-01 8.54e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 4.25e-01 -1.19e-01 7.46e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 4.25e-01 -1.19e-01 7.46e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 4.25e-01 -1.19e-01 7.46e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 4.25e-01 -1.19e-01 7.46e-01
Signaling by CTNNB1 phospho-site mutants 15 4.25e-01 -1.19e-01 7.46e-01
Signaling by GSK3beta mutants 15 4.25e-01 -1.19e-01 7.46e-01
Interleukin-6 family signaling 18 3.82e-01 -1.19e-01 7.34e-01
Signaling by BMP 23 3.24e-01 -1.19e-01 6.86e-01
Resolution of Abasic Sites (AP sites) 38 2.06e-01 1.19e-01 5.63e-01
Cellular response to hypoxia 59 1.15e-01 -1.19e-01 4.52e-01
ChREBP activates metabolic gene expression 7 5.87e-01 1.18e-01 8.44e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 6.15e-01 -1.18e-01 8.54e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 4.79e-01 1.18e-01 7.82e-01
Translation of Structural Proteins 9683701 29 2.71e-01 -1.18e-01 6.40e-01
Diseases of glycosylation 104 3.77e-02 1.18e-01 3.08e-01
TNFR1-mediated ceramide production 6 6.18e-01 1.18e-01 8.54e-01
Interleukin-18 signaling 6 6.18e-01 -1.18e-01 8.54e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 2.35e-01 1.18e-01 6.07e-01
Golgi-to-ER retrograde transport 123 2.43e-02 -1.18e-01 2.61e-01
Hedgehog ‘on’ state 65 1.01e-01 -1.18e-01 4.39e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 4.64e-01 -1.17e-01 7.71e-01
Other interleukin signaling 18 3.89e-01 1.17e-01 7.36e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 4.04e-01 1.17e-01 7.45e-01
Signaling by SCF-KIT 40 2.01e-01 -1.17e-01 5.58e-01
Assembly of the pre-replicative complex 87 5.98e-02 -1.17e-01 3.57e-01
G1/S DNA Damage Checkpoints 54 1.38e-01 -1.17e-01 4.87e-01
RAB geranylgeranylation 62 1.13e-01 -1.16e-01 4.50e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 1.54e-01 1.16e-01 5.04e-01
Cyclin A:Cdk2-associated events at S phase entry 75 8.14e-02 -1.16e-01 4.14e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 4.20e-01 1.16e-01 7.46e-01
PI Metabolism 79 7.39e-02 -1.16e-01 3.94e-01
Somitogenesis 41 1.98e-01 -1.16e-01 5.58e-01
Synthesis of very long-chain fatty acyl-CoAs 22 3.46e-01 -1.16e-01 7.00e-01
p53-Dependent G1 DNA Damage Response 52 1.48e-01 -1.16e-01 5.00e-01
p53-Dependent G1/S DNA damage checkpoint 52 1.48e-01 -1.16e-01 5.00e-01
MAP2K and MAPK activation 36 2.29e-01 1.16e-01 5.97e-01
Signaling by ALK fusions and activated point mutants 89 5.89e-02 -1.16e-01 3.55e-01
Signaling by ALK in cancer 89 5.89e-02 -1.16e-01 3.55e-01
Retrograde transport at the Trans-Golgi-Network 49 1.61e-01 -1.16e-01 5.10e-01
Dectin-1 mediated noncanonical NF-kB signaling 47 1.70e-01 -1.16e-01 5.28e-01
Regulation of lipid metabolism by PPARalpha 107 3.90e-02 -1.16e-01 3.12e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 5.97e-01 -1.15e-01 8.45e-01
MECP2 regulates transcription of neuronal ligands 5 6.55e-01 1.15e-01 8.77e-01
Evasion by RSV of host interferon responses 20 3.72e-01 -1.15e-01 7.26e-01
DNA Replication Pre-Initiation 103 4.32e-02 -1.15e-01 3.24e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 1.68e-01 -1.15e-01 5.23e-01
Diseases associated with surfactant metabolism 5 6.56e-01 1.15e-01 8.77e-01
Visual phototransduction 58 1.30e-01 1.15e-01 4.77e-01
Keratan sulfate degradation 9 5.52e-01 1.15e-01 8.27e-01
RHO GTPases activate CIT 18 4.01e-01 -1.14e-01 7.45e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 5.76e-01 -1.14e-01 8.42e-01
ADP signalling through P2Y purinoceptor 12 18 4.02e-01 -1.14e-01 7.45e-01
Activation of NOXA and translocation to mitochondria 5 6.58e-01 1.14e-01 8.79e-01
Interconversion of nucleotide di- and triphosphates 27 3.05e-01 -1.14e-01 6.75e-01
Scavenging of heme from plasma 70 9.90e-02 1.14e-01 4.39e-01
Signaling by ERBB2 KD Mutants 20 3.78e-01 -1.14e-01 7.33e-01
Cell junction organization 77 8.53e-02 1.13e-01 4.18e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 4.79e-01 -1.13e-01 7.82e-01
PLC beta mediated events 39 2.21e-01 1.13e-01 5.87e-01
TCR signaling 110 4.08e-02 -1.13e-01 3.18e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 4.34e-01 -1.13e-01 7.51e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 3.11e-01 1.13e-01 6.76e-01
Negative regulation of FGFR2 signaling 24 3.40e-01 -1.13e-01 7.00e-01
RHOG GTPase cycle 70 1.04e-01 -1.12e-01 4.42e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.38e-01 1.12e-01 7.53e-01
Processing of Capped Intronless Pre-mRNA 29 2.97e-01 -1.12e-01 6.68e-01
TBC/RABGAPs 45 1.94e-01 1.12e-01 5.57e-01
G beta:gamma signalling through CDC42 17 4.25e-01 -1.12e-01 7.46e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 2.00e-01 -1.12e-01 5.58e-01
TNFR1-induced proapoptotic signaling 24 3.44e-01 1.12e-01 7.00e-01
Cytosolic sulfonation of small molecules 18 4.14e-01 1.11e-01 7.46e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.28e-01 -1.11e-01 7.46e-01
Assembly of the ORC complex at the origin of replication 23 3.57e-01 -1.11e-01 7.12e-01
Degradation of beta-catenin by the destruction complex 72 1.05e-01 -1.10e-01 4.43e-01
Defects in vitamin and cofactor metabolism 21 3.81e-01 -1.10e-01 7.33e-01
Pyrimidine catabolism 9 5.66e-01 -1.10e-01 8.40e-01
Positive epigenetic regulation of rRNA expression 60 1.41e-01 1.10e-01 4.90e-01
Aspirin ADME 13 4.93e-01 1.10e-01 7.90e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.44e-01 -1.09e-01 7.00e-01
SARS-CoV-1 Infection 137 2.73e-02 -1.09e-01 2.76e-01
GRB2 events in EGFR signaling 10 5.50e-01 -1.09e-01 8.27e-01
Membrane Trafficking 575 8.00e-06 -1.09e-01 1.23e-03
Receptor Mediated Mitophagy 11 5.32e-01 -1.09e-01 8.13e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.76e-03 -1.09e-01 5.65e-02
Passive transport by Aquaporins 6 6.46e-01 1.08e-01 8.72e-01
Programmed Cell Death 186 1.09e-02 -1.08e-01 1.83e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 1.00e-02 -1.08e-01 1.79e-01
Translesion Synthesis by POLH 18 4.28e-01 -1.08e-01 7.46e-01
Sema4D in semaphorin signaling 22 3.82e-01 1.08e-01 7.33e-01
C-type lectin receptors (CLRs) 116 4.51e-02 -1.08e-01 3.28e-01
Regulation of TP53 Activity through Methylation 19 4.17e-01 1.08e-01 7.46e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 4.71e-01 1.08e-01 7.76e-01
Ca-dependent events 29 3.16e-01 1.08e-01 6.76e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 1.96e-01 -1.07e-01 5.58e-01
Negative feedback regulation of MAPK pathway 6 6.51e-01 1.07e-01 8.75e-01
Na+/Cl- dependent neurotransmitter transporters 7 6.26e-01 -1.06e-01 8.59e-01
Regulation of pyruvate metabolism 32 2.98e-01 -1.06e-01 6.68e-01
Heparan sulfate/heparin (HS-GAG) metabolism 39 2.51e-01 1.06e-01 6.27e-01
Signaling by FGFR4 32 2.99e-01 -1.06e-01 6.68e-01
Interleukin-15 signaling 14 4.93e-01 -1.06e-01 7.90e-01
Regulation of PLK1 Activity at G2/M Transition 87 8.83e-02 -1.06e-01 4.26e-01
Signaling by EGFR in Cancer 22 3.91e-01 -1.06e-01 7.36e-01
Removal of the Flap Intermediate from the C-strand 17 4.51e-01 -1.05e-01 7.65e-01
ABC-family proteins mediated transport 81 1.01e-01 -1.05e-01 4.39e-01
Toll-like Receptor Cascades 162 2.07e-02 -1.05e-01 2.42e-01
Metal ion SLC transporters 19 4.28e-01 -1.05e-01 7.46e-01
Listeria monocytogenes entry into host cells 17 4.55e-01 -1.05e-01 7.69e-01
Metabolism of polyamines 46 2.20e-01 -1.05e-01 5.85e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 6.09e-01 1.04e-01 8.53e-01
DNA replication initiation 8 6.10e-01 1.04e-01 8.53e-01
RNA Polymerase II Transcription 1185 1.67e-09 -1.04e-01 1.60e-06
COPII-mediated vesicle transport 67 1.42e-01 -1.04e-01 4.92e-01
Loss of Function of TGFBR1 in Cancer 7 6.35e-01 -1.04e-01 8.64e-01
DAG and IP3 signaling 33 3.04e-01 1.03e-01 6.75e-01
RNA Polymerase I Promoter Clearance 64 1.53e-01 1.03e-01 5.02e-01
RNA Polymerase I Transcription 64 1.53e-01 1.03e-01 5.02e-01
RAB GEFs exchange GTP for GDP on RABs 89 9.20e-02 -1.03e-01 4.33e-01
tRNA processing in the mitochondrion 24 3.81e-01 -1.03e-01 7.33e-01
Glycosphingolipid catabolism 31 3.20e-01 1.03e-01 6.78e-01
Class I peroxisomal membrane protein import 20 4.26e-01 -1.03e-01 7.46e-01
RNA polymerase II transcribes snRNA genes 71 1.34e-01 -1.03e-01 4.81e-01
Complement cascade 100 7.55e-02 1.03e-01 3.99e-01
Cell-cell junction organization 56 1.83e-01 1.03e-01 5.46e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 3.47e-01 1.03e-01 7.00e-01
NPAS4 regulates expression of target genes 16 4.78e-01 -1.03e-01 7.82e-01
Peroxisomal lipid metabolism 27 3.57e-01 -1.02e-01 7.12e-01
Formation of xylulose-5-phosphate 5 6.92e-01 1.02e-01 8.99e-01
Branched-chain amino acid catabolism 21 4.18e-01 -1.02e-01 7.46e-01
RNA Polymerase I Transcription Initiation 47 2.27e-01 1.02e-01 5.96e-01
Regulation of MECP2 expression and activity 28 3.51e-01 -1.02e-01 7.03e-01
Transport to the Golgi and subsequent modification 170 2.23e-02 -1.02e-01 2.50e-01
SARS-CoV-1 activates/modulates innate immune responses 40 2.67e-01 -1.02e-01 6.34e-01
CLEC7A (Dectin-1) signaling 85 1.06e-01 -1.01e-01 4.44e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 6.19e-01 1.01e-01 8.55e-01
Acyl chain remodelling of PE 19 4.44e-01 1.01e-01 7.61e-01
Meiotic recombination 36 2.92e-01 -1.01e-01 6.64e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.81e-01 -1.01e-01 7.33e-01
Chaperone Mediated Autophagy 20 4.33e-01 -1.01e-01 7.51e-01
Acyl chain remodeling of CL 5 6.96e-01 -1.01e-01 8.99e-01
FGFR2 alternative splicing 25 3.83e-01 1.01e-01 7.35e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 60 1.79e-01 1.00e-01 5.39e-01
mRNA 3’-end processing 57 1.90e-01 -1.00e-01 5.52e-01
Defective RIPK1-mediated regulated necrosis 7 6.47e-01 1.00e-01 8.72e-01
Signaling by Erythropoietin 24 3.96e-01 -1.00e-01 7.43e-01
Interactions of Rev with host cellular proteins 37 2.93e-01 -1.00e-01 6.64e-01
Netrin mediated repulsion signals 5 6.99e-01 9.99e-02 9.01e-01
Signal regulatory protein family interactions 13 5.33e-01 -9.99e-02 8.14e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 3.29e-01 -9.96e-02 6.92e-01
Gene expression (Transcription) 1391 4.97e-10 -9.96e-02 9.55e-07
Regulation of gene expression in beta cells 7 6.49e-01 9.94e-02 8.73e-01
O-linked glycosylation 81 1.23e-01 9.92e-02 4.62e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.69e-01 -9.91e-02 8.40e-01
Nectin/Necl trans heterodimerization 5 7.01e-01 9.91e-02 9.01e-01
Diseases of programmed cell death 58 1.92e-01 9.91e-02 5.53e-01
Proton-coupled monocarboxylate transport 6 6.74e-01 -9.90e-02 8.91e-01
The activation of arylsulfatases 10 5.88e-01 9.90e-02 8.44e-01
Beta-catenin phosphorylation cascade 17 4.80e-01 -9.89e-02 7.84e-01
Fatty acyl-CoA biosynthesis 35 3.12e-01 -9.88e-02 6.76e-01
Regulation of Complement cascade 96 9.48e-02 9.87e-02 4.37e-01
mRNA Splicing 211 1.38e-02 -9.84e-02 1.96e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 4.14e-01 9.84e-02 7.46e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 4.14e-01 9.84e-02 7.46e-01
Neuronal System 262 6.24e-03 9.81e-02 1.45e-01
Signaling by NOTCH4 68 1.62e-01 -9.80e-02 5.11e-01
NOD1/2 Signaling Pathway 36 3.12e-01 -9.73e-02 6.76e-01
Phase 0 - rapid depolarisation 23 4.20e-01 -9.71e-02 7.46e-01
Spry regulation of FGF signaling 16 5.02e-01 -9.71e-02 7.94e-01
RHO GTPase Effectors 257 7.41e-03 -9.70e-02 1.55e-01
Generation of second messenger molecules 38 3.01e-01 9.70e-02 6.70e-01
Nucleotide salvage 21 4.42e-01 9.69e-02 7.58e-01
G2/M Transition 177 2.62e-02 -9.69e-02 2.70e-01
Mitotic G2-G2/M phases 179 2.54e-02 -9.69e-02 2.65e-01
Vitamin C (ascorbate) metabolism 8 6.36e-01 9.68e-02 8.64e-01
TP53 Regulates Metabolic Genes 77 1.42e-01 -9.67e-02 4.92e-01
Sensory processing of sound 57 2.07e-01 9.66e-02 5.63e-01
SARS-CoV-2 Infection 263 7.14e-03 -9.64e-02 1.53e-01
POLB-Dependent Long Patch Base Excision Repair 8 6.37e-01 9.63e-02 8.65e-01
PD-1 signaling 28 3.78e-01 9.63e-02 7.33e-01
Degradation of DVL 43 2.75e-01 -9.62e-02 6.44e-01
RHOH GTPase cycle 33 3.40e-01 -9.59e-02 7.00e-01
Generic Transcription Pathway 1067 1.23e-07 -9.59e-02 3.93e-05
Sensory perception of sweet, bitter, and umami (glutamate) taste 20 4.59e-01 9.56e-02 7.70e-01
HIV Infection 213 1.64e-02 -9.54e-02 2.11e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 5.84e-01 9.54e-02 8.44e-01
Cytochrome P450 - arranged by substrate type 33 3.43e-01 -9.54e-02 7.00e-01
FRS-mediated FGFR4 signaling 13 5.52e-01 -9.52e-02 8.28e-01
Glutamate and glutamine metabolism 12 5.68e-01 9.51e-02 8.40e-01
Regulation of MITF-M-dependent genes involved in pigmentation 35 3.31e-01 9.50e-02 6.92e-01
Interleukin-1 signaling 99 1.03e-01 -9.49e-02 4.42e-01
Transcriptional Regulation by MECP2 47 2.62e-01 -9.47e-02 6.32e-01
G beta:gamma signalling through PLC beta 17 5.00e-01 9.45e-02 7.93e-01
Presynaptic function of Kainate receptors 17 5.00e-01 9.45e-02 7.93e-01
mRNA Splicing - Major Pathway 203 2.03e-02 -9.45e-02 2.38e-01
Interleukin-1 family signaling 127 6.61e-02 -9.45e-02 3.76e-01
Defects in cobalamin (B12) metabolism 13 5.57e-01 -9.41e-02 8.33e-01
Regulation of CDH11 gene transcription 5 7.16e-01 9.38e-02 9.11e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 6.68e-01 -9.37e-02 8.86e-01
Apoptosis 157 4.38e-02 -9.32e-02 3.24e-01
Senescence-Associated Secretory Phenotype (SASP) 64 1.97e-01 9.32e-02 5.58e-01
Phosphate bond hydrolysis by NTPDase proteins 6 6.94e-01 -9.29e-02 8.99e-01
Purine salvage 12 5.79e-01 -9.24e-02 8.44e-01
Regulation of localization of FOXO transcription factors 11 5.96e-01 9.24e-02 8.45e-01
NRAGE signals death through JNK 52 2.49e-01 9.24e-02 6.27e-01
Signaling by Retinoic Acid 29 3.90e-01 9.22e-02 7.36e-01
Aquaporin-mediated transport 38 3.26e-01 9.22e-02 6.86e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 3.99e-01 9.21e-02 7.45e-01
SHC-mediated cascade:FGFR2 13 5.66e-01 -9.18e-02 8.40e-01
Heme biosynthesis 13 5.66e-01 9.18e-02 8.40e-01
Sema4D induced cell migration and growth-cone collapse 19 4.90e-01 9.15e-02 7.89e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 4.11e-01 9.14e-02 7.46e-01
Sensory processing of sound by inner hair cells of the cochlea 54 2.46e-01 9.14e-02 6.21e-01
Regulation of signaling by CBL 22 4.59e-01 -9.13e-02 7.70e-01
TGFBR3 expression 20 4.81e-01 -9.09e-02 7.84e-01
Oncogene Induced Senescence 33 3.69e-01 -9.04e-02 7.26e-01
Disorders of transmembrane transporters 134 7.35e-02 -8.96e-02 3.94e-01
MET promotes cell motility 32 3.81e-01 -8.95e-02 7.33e-01
Sensory perception of taste 23 4.59e-01 8.92e-02 7.70e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 4.82e-01 8.86e-02 7.84e-01
Toll Like Receptor 2 (TLR2) Cascade 109 1.10e-01 -8.86e-02 4.49e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 1.10e-01 -8.86e-02 4.49e-01
activated TAK1 mediates p38 MAPK activation 23 4.64e-01 -8.83e-02 7.71e-01
EPHA-mediated growth cone collapse 21 4.86e-01 -8.79e-02 7.86e-01
G alpha (s) signalling events 93 1.43e-01 8.78e-02 4.93e-01
Plasma lipoprotein assembly 10 6.31e-01 8.77e-02 8.62e-01
Mitochondrial protein import 63 2.29e-01 8.76e-02 5.97e-01
VEGFR2 mediated vascular permeability 26 4.40e-01 8.75e-02 7.55e-01
RNA Polymerase III Chain Elongation 18 5.20e-01 8.75e-02 8.05e-01
Metabolism of folate and pterines 16 5.45e-01 8.73e-02 8.24e-01
Basigin interactions 21 4.89e-01 8.72e-02 7.89e-01
Translocation of ZAP-70 to Immunological synapse 24 4.60e-01 8.71e-02 7.71e-01
HIV Life Cycle 144 7.14e-02 -8.70e-02 3.90e-01
Telomere C-strand synthesis initiation 13 5.87e-01 8.70e-02 8.44e-01
Metabolism of steroids 120 1.00e-01 -8.69e-02 4.39e-01
RHOD GTPase cycle 49 2.94e-01 -8.66e-02 6.65e-01
SUMOylation of SUMOylation proteins 35 3.77e-01 -8.64e-02 7.31e-01
Mitochondrial iron-sulfur cluster biogenesis 13 5.90e-01 -8.62e-02 8.44e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 4.38e-01 8.62e-02 7.54e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 6.73e-01 -8.61e-02 8.90e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 3.47e-01 8.59e-02 7.00e-01
Signaling by RAS mutants 40 3.47e-01 8.59e-02 7.00e-01
Signaling by moderate kinase activity BRAF mutants 40 3.47e-01 8.59e-02 7.00e-01
Signaling downstream of RAS mutants 40 3.47e-01 8.59e-02 7.00e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 6.96e-01 8.54e-02 8.99e-01
G beta:gamma signalling through PI3Kgamma 22 4.88e-01 8.54e-02 7.88e-01
Integrin cell surface interactions 64 2.38e-01 8.52e-02 6.11e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 6.97e-01 -8.50e-02 9.00e-01
Fc epsilon receptor (FCERI) signaling 179 5.01e-02 -8.49e-02 3.42e-01
Formation of the beta-catenin:TCF transactivating complex 44 3.31e-01 8.47e-02 6.92e-01
Type I hemidesmosome assembly 8 6.79e-01 8.46e-02 8.92e-01
Synthesis of diphthamide-EEF2 8 6.79e-01 8.45e-02 8.92e-01
RNA Polymerase II Transcription Termination 66 2.37e-01 -8.42e-02 6.10e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 5.27e-01 -8.39e-02 8.10e-01
Trafficking of AMPA receptors 19 5.27e-01 -8.39e-02 8.10e-01
Formation of the Early Elongation Complex 33 4.05e-01 8.38e-02 7.45e-01
Formation of the HIV-1 Early Elongation Complex 33 4.05e-01 8.38e-02 7.45e-01
Vesicle-mediated transport 663 2.36e-04 -8.38e-02 1.46e-02
Signaling by ERBB4 45 3.32e-01 -8.36e-02 6.92e-01
MECP2 regulates transcription factors 5 7.46e-01 -8.35e-02 9.24e-01
Binding and Uptake of Ligands by Scavenger Receptors 90 1.72e-01 8.33e-02 5.31e-01
Cilium Assembly 187 4.95e-02 -8.33e-02 3.42e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 6.83e-01 -8.33e-02 8.93e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.01e-01 -8.33e-02 7.45e-01
MAP kinase activation 63 2.53e-01 -8.32e-02 6.27e-01
Maturation of spike protein 9694548 35 3.95e-01 -8.31e-02 7.42e-01
ER to Golgi Anterograde Transport 145 8.45e-02 -8.30e-02 4.18e-01
Prostanoid ligand receptors 8 6.84e-01 -8.30e-02 8.94e-01
Miscellaneous substrates 7 7.04e-01 8.29e-02 9.03e-01
IRAK1 recruits IKK complex 14 5.91e-01 -8.28e-02 8.44e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 5.91e-01 -8.28e-02 8.44e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 5.11e-01 8.28e-02 8.01e-01
Neurodegenerative Diseases 21 5.11e-01 8.28e-02 8.01e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 1.87e-01 -8.28e-02 5.48e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 1.87e-01 -8.28e-02 5.48e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 1.87e-01 -8.28e-02 5.48e-01
Anchoring of the basal body to the plasma membrane 97 1.60e-01 -8.25e-02 5.10e-01
Striated Muscle Contraction 25 4.76e-01 8.23e-02 7.81e-01
Regulation of TP53 Degradation 35 4.00e-01 -8.23e-02 7.45e-01
Activation of C3 and C5 7 7.06e-01 8.22e-02 9.04e-01
Negative regulation of FLT3 15 5.82e-01 8.21e-02 8.44e-01
Methylation 13 6.09e-01 -8.19e-02 8.53e-01
Recycling of bile acids and salts 8 6.88e-01 -8.19e-02 8.97e-01
Vitamin B1 (thiamin) metabolism 5 7.51e-01 -8.19e-02 9.24e-01
Metabolism of RNA 717 1.94e-04 -8.17e-02 1.29e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 6.25e-01 -8.15e-02 8.58e-01
alpha-linolenic acid (ALA) metabolism 12 6.25e-01 -8.15e-02 8.58e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 4.25e-01 -8.14e-02 7.46e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 4.25e-01 -8.14e-02 7.46e-01
Signaling by LTK 10 6.56e-01 8.14e-02 8.77e-01
Signaling by RAF1 mutants 36 4.00e-01 8.11e-02 7.45e-01
Formation of the Editosome 6 7.31e-01 -8.11e-02 9.17e-01
mRNA Editing: C to U Conversion 6 7.31e-01 -8.11e-02 9.17e-01
Toll Like Receptor 9 (TLR9) Cascade 108 1.46e-01 -8.10e-02 5.00e-01
Reversal of alkylation damage by DNA dioxygenases 7 7.11e-01 -8.09e-02 9.07e-01
Meiosis 66 2.56e-01 -8.08e-02 6.29e-01
RNA Polymerase II Pre-transcription Events 77 2.21e-01 -8.07e-02 5.87e-01
Cytokine Signaling in Immune system 662 4.06e-04 -8.06e-02 2.17e-02
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 5.43e-01 -8.05e-02 8.23e-01
Amino acids regulate mTORC1 48 3.35e-01 8.04e-02 6.95e-01
Pentose phosphate pathway 13 6.16e-01 -8.03e-02 8.54e-01
Acyl chain remodelling of PS 14 6.03e-01 8.03e-02 8.50e-01
Glutamate Neurotransmitter Release Cycle 20 5.35e-01 8.01e-02 8.16e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.51e-01 -8.01e-02 5.00e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 1.51e-01 -8.01e-02 5.00e-01
Constitutive Signaling by Overexpressed ERBB2 11 6.47e-01 -7.97e-02 8.72e-01
Asparagine N-linked glycosylation 284 2.09e-02 -7.97e-02 2.42e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 6.19e-01 7.96e-02 8.55e-01
DNA Double-Strand Break Repair 137 1.08e-01 -7.96e-02 4.48e-01
Growth hormone receptor signaling 20 5.38e-01 -7.95e-02 8.19e-01
Neddylation 215 4.50e-02 -7.93e-02 3.28e-01
Metabolism of non-coding RNA 53 3.18e-01 -7.93e-02 6.76e-01
snRNP Assembly 53 3.18e-01 -7.93e-02 6.76e-01
Regulation of RUNX3 expression and activity 45 3.58e-01 -7.92e-02 7.13e-01
Erythrocytes take up carbon dioxide and release oxygen 11 6.52e-01 -7.86e-02 8.75e-01
O2/CO2 exchange in erythrocytes 11 6.52e-01 -7.86e-02 8.75e-01
SIRT1 negatively regulates rRNA expression 22 5.24e-01 7.84e-02 8.09e-01
FOXO-mediated transcription 57 3.07e-01 -7.83e-02 6.76e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 5.16e-01 7.83e-02 8.03e-01
RUNX3 Regulates Immune Response and Cell Migration 5 7.62e-01 -7.81e-02 9.29e-01
Toll Like Receptor 4 (TLR4) Cascade 138 1.13e-01 -7.81e-02 4.51e-01
Signaling by TGF-beta Receptor Complex 90 2.01e-01 -7.80e-02 5.58e-01
Downstream signaling of activated FGFR1 22 5.28e-01 -7.76e-02 8.11e-01
Gastrulation 73 2.52e-01 -7.75e-02 6.27e-01
Activation of BAD and translocation to mitochondria 15 6.03e-01 7.75e-02 8.50e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 5.70e-01 7.74e-02 8.40e-01
AURKA Activation by TPX2 72 2.57e-01 -7.73e-02 6.29e-01
Metabolism of Angiotensinogen to Angiotensins 12 6.43e-01 -7.72e-02 8.69e-01
Collagen chain trimerization 26 4.96e-01 7.71e-02 7.93e-01
Transcription of the HIV genome 67 2.76e-01 -7.70e-02 6.44e-01
Cellular response to heat stress 92 2.02e-01 -7.70e-02 5.58e-01
Nuclear Envelope (NE) Reassembly 68 2.74e-01 -7.68e-02 6.43e-01
Signaling by FGFR2 in disease 33 4.45e-01 -7.68e-02 7.61e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.90e-01 7.67e-02 7.36e-01
HIV Transcription Elongation 42 3.90e-01 7.67e-02 7.36e-01
Tat-mediated elongation of the HIV-1 transcript 42 3.90e-01 7.67e-02 7.36e-01
Maternal to zygotic transition (MZT) 71 2.66e-01 -7.64e-02 6.34e-01
Signalling to ERKs 32 4.55e-01 -7.63e-02 7.69e-01
Late Phase of HIV Life Cycle 131 1.32e-01 -7.62e-02 4.81e-01
Signaling by PDGF 48 3.64e-01 7.58e-02 7.21e-01
G-protein mediated events 43 3.91e-01 7.56e-02 7.36e-01
RNA Polymerase III Abortive And Retractive Initiation 40 4.09e-01 7.54e-02 7.46e-01
RNA Polymerase III Transcription 40 4.09e-01 7.54e-02 7.46e-01
SARS-CoV-2-host interactions 181 8.05e-02 -7.53e-02 4.11e-01
Amyloid fiber formation 51 3.52e-01 7.53e-02 7.05e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 5.00e-01 7.50e-02 7.93e-01
Activation of kainate receptors upon glutamate binding 25 5.16e-01 7.50e-02 8.03e-01
Neurofascin interactions 5 7.71e-01 7.50e-02 9.30e-01
Export of Viral Ribonucleoproteins from Nucleus 33 4.56e-01 -7.50e-02 7.70e-01
tRNA Aminoacylation 42 4.01e-01 -7.50e-02 7.45e-01
TICAM1-dependent activation of IRF3/IRF7 13 6.40e-01 7.48e-02 8.68e-01
SUMOylation of intracellular receptors 26 5.09e-01 7.48e-02 8.00e-01
GPVI-mediated activation cascade 31 4.71e-01 -7.48e-02 7.76e-01
Host Interactions of HIV factors 118 1.62e-01 -7.45e-02 5.11e-01
Assembly Of The HIV Virion 15 6.18e-01 7.44e-02 8.54e-01
Transport of vitamins, nucleosides, and related molecules 31 4.75e-01 7.42e-02 7.80e-01
PRC2 methylates histones and DNA 27 5.08e-01 7.35e-02 8.00e-01
RHO GTPases Activate NADPH Oxidases 21 5.60e-01 -7.35e-02 8.35e-01
Lagging Strand Synthesis 20 5.70e-01 -7.35e-02 8.40e-01
Cholesterol biosynthesis 26 5.17e-01 -7.34e-02 8.03e-01
Dual Incision in GG-NER 41 4.16e-01 -7.34e-02 7.46e-01
EGFR downregulation 26 5.18e-01 -7.32e-02 8.04e-01
Intra-Golgi traffic 43 4.06e-01 -7.32e-02 7.45e-01
Regulation of TP53 Expression and Degradation 36 4.48e-01 -7.30e-02 7.62e-01
Citric acid cycle (TCA cycle) 34 4.62e-01 -7.29e-02 7.71e-01
NCAM signaling for neurite out-growth 47 3.88e-01 7.27e-02 7.36e-01
Chemokine receptors bind chemokines 39 4.32e-01 -7.27e-02 7.50e-01
Activation of G protein gated Potassium channels 18 5.93e-01 -7.27e-02 8.44e-01
G protein gated Potassium channels 18 5.93e-01 -7.27e-02 8.44e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 5.93e-01 -7.27e-02 8.44e-01
EPH-Ephrin signaling 79 2.64e-01 -7.27e-02 6.34e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 5.47e-01 -7.25e-02 8.27e-01
Mitotic Prophase 96 2.21e-01 -7.22e-02 5.87e-01
G beta:gamma signalling through BTK 15 6.29e-01 -7.21e-02 8.61e-01
Receptor-type tyrosine-protein phosphatases 11 6.80e-01 7.19e-02 8.92e-01
Interleukin-37 signaling 19 5.89e-01 -7.16e-02 8.44e-01
Viral Infection Pathways 770 7.62e-04 -7.13e-02 3.49e-02
Smooth Muscle Contraction 34 4.72e-01 7.13e-02 7.77e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 5.55e-01 7.11e-02 8.30e-01
TP53 Regulates Transcription of Cell Death Genes 42 4.25e-01 7.11e-02 7.46e-01
Signaling by Activin 13 6.57e-01 -7.10e-02 8.78e-01
Transport of the SLBP Dependant Mature mRNA 36 4.61e-01 -7.10e-02 7.71e-01
Activation of HOX genes during differentiation 68 3.13e-01 7.07e-02 6.76e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 3.13e-01 7.07e-02 6.76e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 2.11e-01 -7.07e-02 5.70e-01
FasL/ CD95L signaling 5 7.84e-01 -7.06e-02 9.34e-01
CTLA4 inhibitory signaling 21 5.77e-01 -7.03e-02 8.43e-01
Transport of the SLBP independent Mature mRNA 35 4.72e-01 -7.02e-02 7.77e-01
Uptake and actions of bacterial toxins 27 5.29e-01 7.00e-02 8.11e-01
Condensation of Prophase Chromosomes 27 5.30e-01 6.99e-02 8.12e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 7.49e-01 -6.97e-02 9.24e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 5.90e-01 6.97e-02 8.44e-01
Recycling pathway of L1 40 4.46e-01 6.96e-02 7.62e-01
Phase I - Functionalization of compounds 62 3.44e-01 6.95e-02 7.00e-01
Synthesis of PIPs at the Golgi membrane 16 6.31e-01 6.93e-02 8.62e-01
IL-6-type cytokine receptor ligand interactions 12 6.78e-01 6.93e-02 8.92e-01
DNA Damage Reversal 8 7.35e-01 -6.92e-02 9.17e-01
Uptake and function of diphtheria toxin 6 7.70e-01 -6.89e-02 9.30e-01
Formation of tubulin folding intermediates by CCT/TriC 21 5.86e-01 6.87e-02 8.44e-01
Negative regulation of FGFR3 signaling 21 5.88e-01 -6.84e-02 8.44e-01
Interleukin receptor SHC signaling 23 5.71e-01 -6.83e-02 8.40e-01
Regulation of TNFR1 signaling 47 4.18e-01 6.82e-02 7.46e-01
SRP-dependent cotranslational protein targeting to membrane 111 2.18e-01 -6.77e-02 5.83e-01
Caspase activation via Death Receptors in the presence of ligand 16 6.39e-01 -6.77e-02 8.68e-01
Synthesis of pyrophosphates in the cytosol 8 7.40e-01 -6.77e-02 9.21e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 5.44e-01 -6.75e-02 8.23e-01
Phosphorylation of Emi1 6 7.75e-01 -6.75e-02 9.31e-01
Adaptive Immune System 765 1.54e-03 -6.73e-02 5.33e-02
Aggrephagy 34 5.00e-01 6.68e-02 7.93e-01
Signaling by NOTCH2 33 5.07e-01 6.68e-02 7.99e-01
Thromboxane signalling through TP receptor 20 6.05e-01 6.68e-02 8.51e-01
Myoclonic epilepsy of Lafora 8 7.44e-01 6.67e-02 9.23e-01
Metabolism of carbohydrates 236 7.77e-02 6.67e-02 4.05e-01
SUMOylation of DNA replication proteins 46 4.35e-01 -6.66e-02 7.51e-01
Platelet Adhesion to exposed collagen 14 6.67e-01 6.65e-02 8.86e-01
Translation 293 5.07e-02 -6.64e-02 3.42e-01
Dual incision in TC-NER 63 3.64e-01 -6.61e-02 7.22e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 5.69e-01 -6.58e-02 8.40e-01
NR1H2 and NR1H3-mediated signaling 38 4.85e-01 6.55e-02 7.86e-01
DNA Damage Recognition in GG-NER 38 4.85e-01 6.54e-02 7.86e-01
Processive synthesis on the C-strand of the telomere 19 6.22e-01 -6.54e-02 8.57e-01
Clathrin-mediated endocytosis 127 2.04e-01 -6.53e-02 5.61e-01
Glycogen storage diseases 13 6.84e-01 6.53e-02 8.93e-01
Prevention of phagosomal-lysosomal fusion 9 7.35e-01 6.52e-02 9.17e-01
The phototransduction cascade 26 5.65e-01 -6.52e-02 8.40e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 7.35e-01 -6.52e-02 9.17e-01
Formation of TC-NER Pre-Incision Complex 51 4.23e-01 -6.48e-02 7.46e-01
Class B/2 (Secretin family receptors) 54 4.11e-01 6.47e-02 7.46e-01
Signaling by NOTCH3 42 4.68e-01 6.47e-02 7.75e-01
Rev-mediated nuclear export of HIV RNA 35 5.08e-01 -6.46e-02 8.00e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 7.23e-01 -6.46e-02 9.13e-01
NOTCH2 intracellular domain regulates transcription 11 7.11e-01 6.46e-02 9.07e-01
Vpr-mediated nuclear import of PICs 34 5.15e-01 -6.45e-02 8.03e-01
Other semaphorin interactions 16 6.55e-01 -6.45e-02 8.77e-01
PI3K/AKT Signaling in Cancer 83 3.12e-01 6.41e-02 6.76e-01
p75NTR negatively regulates cell cycle via SC1 5 8.04e-01 6.41e-02 9.41e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 4.62e-01 6.40e-02 7.71e-01
Cytosolic sensors of pathogen-associated DNA 63 3.80e-01 6.40e-02 7.33e-01
FGFR2 mutant receptor activation 23 5.96e-01 6.39e-02 8.45e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 8.05e-01 -6.38e-02 9.41e-01
Signaling by TGFB family members 137 1.98e-01 -6.37e-02 5.58e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 7.71e-01 -6.35e-02 9.30e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 4.24e-01 6.35e-02 7.46e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 4.24e-01 6.35e-02 7.46e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 4.24e-01 6.35e-02 7.46e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 4.24e-01 6.35e-02 7.46e-01
Signaling by NOTCH1 in Cancer 53 4.24e-01 6.35e-02 7.46e-01
Estrogen-dependent gene expression 96 2.83e-01 -6.35e-02 6.54e-01
Transcriptional regulation by RUNX2 87 3.07e-01 -6.33e-02 6.76e-01
Autophagy 142 1.93e-01 -6.33e-02 5.54e-01
COPI-mediated anterograde transport 92 2.94e-01 -6.32e-02 6.65e-01
B-WICH complex positively regulates rRNA expression 45 4.63e-01 6.32e-02 7.71e-01
Organelle biogenesis and maintenance 278 7.25e-02 -6.26e-02 3.92e-01
Synthesis of bile acids and bile salts 25 5.88e-01 -6.26e-02 8.44e-01
FGFR2b ligand binding and activation 6 7.91e-01 6.24e-02 9.34e-01
Acyl chain remodelling of PI 10 7.33e-01 -6.24e-02 9.17e-01
Signaling by the B Cell Receptor (BCR) 150 1.88e-01 -6.23e-02 5.49e-01
Signaling by Leptin 10 7.33e-01 -6.23e-02 9.17e-01
Removal of the Flap Intermediate 14 6.88e-01 -6.20e-02 8.97e-01
Bile acid and bile salt metabolism 28 5.71e-01 -6.19e-02 8.40e-01
CREB3 factors activate genes 6 7.93e-01 -6.17e-02 9.35e-01
p75 NTR receptor-mediated signalling 89 3.15e-01 6.16e-02 6.76e-01
MicroRNA (miRNA) biogenesis 24 6.02e-01 6.15e-02 8.50e-01
DNA Damage/Telomere Stress Induced Senescence 42 4.92e-01 6.12e-02 7.90e-01
Translation initiation complex formation 58 4.21e-01 -6.11e-02 7.46e-01
Keratinization 34 5.37e-01 6.11e-02 8.18e-01
Purine ribonucleoside monophosphate biosynthesis 9 7.52e-01 6.09e-02 9.24e-01
Cytoprotection by HMOX1 53 4.44e-01 -6.07e-02 7.61e-01
Infectious disease 951 1.55e-03 -6.06e-02 5.33e-02
MyD88 dependent cascade initiated on endosome 101 2.93e-01 -6.05e-02 6.64e-01
TRAF6 mediated IRF7 activation 15 6.85e-01 -6.04e-02 8.94e-01
Linoleic acid (LA) metabolism 7 7.82e-01 6.04e-02 9.34e-01
TRAIL signaling 8 7.68e-01 -6.02e-02 9.29e-01
Ribosomal scanning and start codon recognition 58 4.28e-01 -6.02e-02 7.46e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.25e-01 -6.01e-02 6.86e-01
TGF-beta receptor signaling activates SMADs 45 4.86e-01 -6.01e-02 7.86e-01
Loss of Nlp from mitotic centrosomes 69 3.89e-01 -6.00e-02 7.36e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 3.89e-01 -6.00e-02 7.36e-01
Glycosphingolipid biosynthesis 16 6.78e-01 -5.99e-02 8.92e-01
MyD88 cascade initiated on plasma membrane 95 3.13e-01 -5.99e-02 6.76e-01
Toll Like Receptor 10 (TLR10) Cascade 95 3.13e-01 -5.99e-02 6.76e-01
Toll Like Receptor 5 (TLR5) Cascade 95 3.13e-01 -5.99e-02 6.76e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 7.44e-01 -5.97e-02 9.23e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 6.70e-01 -5.97e-02 8.88e-01
Activated point mutants of FGFR2 7 7.85e-01 -5.96e-02 9.34e-01
DNA Repair 288 8.23e-02 -5.95e-02 4.16e-01
MyD88-independent TLR4 cascade 108 2.86e-01 -5.94e-02 6.57e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 2.86e-01 -5.94e-02 6.57e-01
Diseases of signal transduction by growth factor receptors and second messengers 399 4.22e-02 -5.93e-02 3.23e-01
SARS-CoV Infections 428 3.56e-02 -5.92e-02 3.01e-01
tRNA processing in the nucleus 59 4.32e-01 -5.92e-02 7.50e-01
O-linked glycosylation of mucins 46 4.88e-01 -5.91e-02 7.88e-01
Termination of O-glycan biosynthesis 15 6.93e-01 5.89e-02 8.99e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 4.36e-01 -5.87e-02 7.51e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 6.34e-01 -5.86e-02 8.63e-01
Metabolism of proteins 1761 4.86e-05 -5.84e-02 4.67e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 3.04e-01 -5.83e-02 6.75e-01
RHOT2 GTPase cycle 7 7.89e-01 -5.83e-02 9.34e-01
Aspartate and asparagine metabolism 8 7.75e-01 -5.83e-02 9.31e-01
Signaling by FGFR1 42 5.14e-01 -5.82e-02 8.02e-01
RAS processing 23 6.30e-01 -5.81e-02 8.61e-01
Signaling by Interleukins 387 4.98e-02 -5.81e-02 3.42e-01
Triglyceride biosynthesis 9 7.63e-01 -5.80e-02 9.29e-01
mRNA Splicing - Minor Pathway 50 4.78e-01 5.80e-02 7.82e-01
Signaling by Rho GTPases 603 1.52e-02 -5.79e-02 2.01e-01
Protein hydroxylation 17 6.80e-01 5.79e-02 8.92e-01
HDL assembly 6 8.07e-01 5.76e-02 9.42e-01
VEGFA-VEGFR2 Pathway 93 3.39e-01 -5.73e-02 7.00e-01
MITF-M-regulated melanocyte development 110 3.01e-01 -5.71e-02 6.70e-01
Post-translational protein modification 1232 7.89e-04 -5.69e-02 3.52e-02
Reduction of cytosolic Ca++ levels 9 7.68e-01 -5.68e-02 9.29e-01
SHC-related events triggered by IGF1R 7 7.95e-01 -5.67e-02 9.36e-01
Immune System 1828 6.00e-05 -5.67e-02 4.86e-03
Integration of energy metabolism 87 3.61e-01 5.66e-02 7.18e-01
NoRC negatively regulates rRNA expression 60 4.48e-01 5.66e-02 7.62e-01
Stimuli-sensing channels 78 3.88e-01 5.65e-02 7.36e-01
Beta-catenin independent WNT signaling 124 2.78e-01 -5.64e-02 6.49e-01
Selective autophagy 77 3.92e-01 -5.64e-02 7.38e-01
Macroautophagy 128 2.71e-01 -5.63e-02 6.40e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 4.66e-01 -5.63e-02 7.74e-01
G alpha (12/13) signalling events 68 4.22e-01 5.63e-02 7.46e-01
Negative epigenetic regulation of rRNA expression 63 4.40e-01 5.62e-02 7.55e-01
DNA strand elongation 32 5.83e-01 -5.61e-02 8.44e-01
Interleukin-2 family signaling 38 5.51e-01 -5.58e-02 8.27e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.18e-01 5.58e-02 9.11e-01
G2 Phase 5 8.29e-01 -5.56e-02 9.54e-01
Phase II - Conjugation of compounds 68 4.28e-01 -5.56e-02 7.46e-01
Transport of Mature Transcript to Cytoplasm 81 3.89e-01 -5.54e-02 7.36e-01
Signaling by VEGF 100 3.40e-01 -5.52e-02 7.00e-01
Recycling of eIF2:GDP 8 7.87e-01 -5.51e-02 9.34e-01
Signaling by ALK 24 6.42e-01 5.49e-02 8.68e-01
Signaling by NODAL 15 7.13e-01 5.48e-02 9.08e-01
tRNA modification in the nucleus and cytosol 43 5.35e-01 -5.47e-02 8.16e-01
Reactions specific to the complex N-glycan synthesis pathway 7 8.02e-01 5.47e-02 9.41e-01
Cellular responses to mechanical stimuli 83 3.90e-01 5.46e-02 7.36e-01
Response of endothelial cells to shear stress 83 3.90e-01 5.46e-02 7.36e-01
SUMOylation of RNA binding proteins 47 5.17e-01 -5.46e-02 8.03e-01
ADORA2B mediated anti-inflammatory cytokines production 35 5.79e-01 5.43e-02 8.44e-01
CLEC7A/inflammasome pathway 6 8.18e-01 5.42e-02 9.46e-01
Josephin domain DUBs 10 7.67e-01 5.42e-02 9.29e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 2.19e-02 -5.40e-02 2.49e-01
SUMOylation 167 2.30e-01 -5.38e-02 5.98e-01
RHO GTPases activate PAKs 20 6.78e-01 -5.37e-02 8.92e-01
Activation of GABAB receptors 29 6.17e-01 5.36e-02 8.54e-01
GABA B receptor activation 29 6.17e-01 5.36e-02 8.54e-01
Defective pyroptosis 27 6.32e-01 5.33e-02 8.62e-01
RUNX2 regulates osteoblast differentiation 16 7.13e-01 5.31e-02 9.08e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 4.47e-01 -5.30e-02 7.62e-01
Transmission across Chemical Synapses 179 2.22e-01 5.29e-02 5.88e-01
VEGF binds to VEGFR leading to receptor dimerization 5 8.38e-01 -5.29e-02 9.54e-01
VEGF ligand-receptor interactions 5 8.38e-01 -5.29e-02 9.54e-01
Kinesins 51 5.14e-01 5.28e-02 8.02e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 3.62e-01 -5.28e-02 7.19e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 5.51e-01 -5.26e-02 8.27e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 8.39e-01 -5.25e-02 9.54e-01
Diseases associated with the TLR signaling cascade 29 6.25e-01 -5.25e-02 8.58e-01
Diseases of Immune System 29 6.25e-01 -5.25e-02 8.58e-01
Hydrolysis of LPC 8 7.97e-01 5.24e-02 9.37e-01
Diseases of metabolism 198 2.06e-01 5.21e-02 5.63e-01
NGF-stimulated transcription 32 6.10e-01 5.21e-02 8.53e-01
RNA Polymerase III Transcription Initiation 36 5.89e-01 5.21e-02 8.44e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 4.47e-01 -5.18e-02 7.62e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 7.56e-01 -5.18e-02 9.26e-01
ESR-mediated signaling 157 2.64e-01 -5.17e-02 6.34e-01
Cardiac conduction 88 4.03e-01 -5.16e-02 7.45e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 5.64e-01 -5.15e-02 8.40e-01
Interleukin-17 signaling 68 4.63e-01 -5.14e-02 7.71e-01
Ovarian tumor domain proteases 37 5.89e-01 -5.14e-02 8.44e-01
Post NMDA receptor activation events 60 4.91e-01 5.14e-02 7.89e-01
SHC-mediated cascade:FGFR4 11 7.68e-01 5.13e-02 9.29e-01
Inhibition of Signaling by Overexpressed EGFR 5 8.43e-01 5.12e-02 9.57e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 8.43e-01 5.12e-02 9.57e-01
SHC1 events in ERBB4 signaling 10 7.79e-01 -5.11e-02 9.34e-01
Telomere Maintenance 78 4.35e-01 5.11e-02 7.51e-01
Transport of nucleotide sugars 9 7.91e-01 -5.10e-02 9.34e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 6.72e-01 5.09e-02 8.90e-01
Erythrocytes take up oxygen and release carbon dioxide 7 8.16e-01 -5.08e-02 9.45e-01
Glucagon-type ligand receptors 19 7.04e-01 5.04e-02 9.03e-01
Cellular response to chemical stress 178 2.46e-01 -5.04e-02 6.21e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 6.06e-01 5.03e-02 8.52e-01
Cargo recognition for clathrin-mediated endocytosis 88 4.15e-01 -5.03e-02 7.46e-01
Release of apoptotic factors from the mitochondria 6 8.32e-01 5.00e-02 9.54e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 6.03e-01 -5.00e-02 8.50e-01
Mitochondrial protein degradation 96 3.99e-01 -4.99e-02 7.45e-01
CDC42 GTPase cycle 139 3.11e-01 4.98e-02 6.76e-01
tRNA processing 128 3.30e-01 -4.98e-02 6.92e-01
HSF1 activation 25 6.67e-01 -4.97e-02 8.86e-01
CD28 co-stimulation 33 6.22e-01 4.95e-02 8.57e-01
DCC mediated attractive signaling 13 7.58e-01 -4.94e-02 9.26e-01
Metabolism of lipids 632 3.41e-02 -4.94e-02 2.99e-01
Platelet calcium homeostasis 22 6.89e-01 -4.93e-02 8.98e-01
RAC2 GTPase cycle 85 4.33e-01 -4.92e-02 7.51e-01
Inwardly rectifying K+ channels 22 6.91e-01 -4.90e-02 8.98e-01
Regulation of signaling by NODAL 6 8.38e-01 -4.81e-02 9.54e-01
Cell death signalling via NRAGE, NRIF and NADE 69 4.91e-01 4.79e-02 7.89e-01
Signaling by NOTCH1 66 5.01e-01 4.79e-02 7.94e-01
Sema4D mediated inhibition of cell attachment and migration 7 8.26e-01 4.79e-02 9.54e-01
Glycosphingolipid metabolism 47 5.72e-01 4.77e-02 8.40e-01
Disease 1606 1.46e-03 -4.77e-02 5.29e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 5.26e-01 -4.77e-02 8.10e-01
FCERI mediated NF-kB activation 129 3.53e-01 -4.74e-02 7.05e-01
RORA activates gene expression 18 7.28e-01 -4.73e-02 9.16e-01
SHC1 events in EGFR signaling 11 7.86e-01 -4.73e-02 9.34e-01
Alternative complement activation 5 8.55e-01 -4.72e-02 9.57e-01
G-protein beta:gamma signalling 29 6.60e-01 4.71e-02 8.80e-01
RNA Polymerase I Promoter Escape 45 5.85e-01 4.71e-02 8.44e-01
Activation of NMDA receptors and postsynaptic events 70 4.97e-01 4.70e-02 7.93e-01
Regulation of NF-kappa B signaling 18 7.31e-01 4.68e-02 9.17e-01
SUMOylation of transcription factors 16 7.46e-01 4.67e-02 9.24e-01
RHOB GTPase cycle 64 5.18e-01 4.67e-02 8.04e-01
PCNA-Dependent Long Patch Base Excision Repair 21 7.12e-01 -4.66e-02 9.08e-01
RHO GTPase cycle 408 1.07e-01 -4.66e-02 4.47e-01
Interleukin-23 signaling 7 8.31e-01 -4.65e-02 9.54e-01
Interaction between L1 and Ankyrins 26 6.83e-01 -4.63e-02 8.93e-01
Processing of SMDT1 15 7.56e-01 -4.63e-02 9.26e-01
Signaling by WNT in cancer 30 6.64e-01 -4.59e-02 8.83e-01
Sodium/Calcium exchangers 9 8.12e-01 -4.58e-02 9.44e-01
Molybdenum cofactor biosynthesis 6 8.46e-01 4.57e-02 9.57e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 4.91e-01 -4.57e-02 7.89e-01
PIWI-interacting RNA (piRNA) biogenesis 23 7.05e-01 4.55e-02 9.03e-01
Asymmetric localization of PCP proteins 49 5.82e-01 -4.55e-02 8.44e-01
Formation of WDR5-containing histone-modifying complexes 42 6.11e-01 4.54e-02 8.53e-01
Intraflagellar transport 47 5.91e-01 -4.53e-02 8.44e-01
Cell surface interactions at the vascular wall 170 3.10e-01 4.52e-02 6.76e-01
Homology Directed Repair 110 4.15e-01 -4.50e-02 7.46e-01
Defensins 8 8.26e-01 4.48e-02 9.54e-01
Transcriptional Regulation by TP53 343 1.54e-01 -4.48e-02 5.03e-01
Reproduction 84 4.78e-01 -4.48e-02 7.82e-01
Glycogen metabolism 21 7.23e-01 -4.47e-02 9.13e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 7.66e-01 -4.44e-02 9.29e-01
Mitochondrial Uncoupling 6 8.51e-01 -4.44e-02 9.57e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 7.99e-01 -4.44e-02 9.38e-01
Transcriptional regulation of granulopoiesis 44 6.11e-01 4.44e-02 8.53e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 7.82e-01 -4.43e-02 9.34e-01
MHC class II antigen presentation 113 4.19e-01 -4.40e-02 7.46e-01
Elevation of cytosolic Ca2+ levels 13 7.84e-01 -4.40e-02 9.34e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 6.16e-01 4.37e-02 8.54e-01
Glycogen breakdown (glycogenolysis) 12 7.94e-01 -4.36e-02 9.35e-01
Adherens junctions interactions 37 6.46e-01 4.36e-02 8.72e-01
Diseases associated with N-glycosylation of proteins 20 7.38e-01 4.33e-02 9.19e-01
SUMOylation of ubiquitinylation proteins 39 6.41e-01 -4.31e-02 8.68e-01
SARS-CoV-1-host interactions 94 4.70e-01 -4.31e-02 7.76e-01
rRNA processing in the nucleus and cytosol 189 3.08e-01 4.30e-02 6.76e-01
Regulation of CDH11 Expression and Function 22 7.28e-01 -4.29e-02 9.16e-01
Signaling by GPCR 441 1.23e-01 4.28e-02 4.62e-01
Regulation of insulin secretion 62 5.60e-01 4.28e-02 8.35e-01
Fanconi Anemia Pathway 36 6.57e-01 -4.28e-02 8.78e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 6.80e-01 -4.28e-02 8.92e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 5.97e-01 -4.28e-02 8.45e-01
Negative regulation of FGFR4 signaling 22 7.29e-01 -4.28e-02 9.16e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.99e-01 -4.26e-02 7.93e-01
Signaling by WNT 237 2.61e-01 -4.24e-02 6.32e-01
Chromatin modifying enzymes 213 2.87e-01 4.24e-02 6.57e-01
Chromatin organization 213 2.87e-01 4.24e-02 6.57e-01
RUNX2 regulates bone development 21 7.37e-01 -4.23e-02 9.19e-01
MAPK family signaling cascades 259 2.41e-01 -4.23e-02 6.16e-01
Formation of paraxial mesoderm 52 6.00e-01 -4.21e-02 8.47e-01
Signaling by ROBO receptors 189 3.19e-01 -4.20e-02 6.77e-01
SARS-CoV-2 modulates host translation machinery 49 6.13e-01 4.18e-02 8.54e-01
RET signaling 32 6.83e-01 4.17e-02 8.93e-01
The NLRP3 inflammasome 16 7.73e-01 4.17e-02 9.30e-01
Toll Like Receptor 3 (TLR3) Cascade 104 4.62e-01 -4.17e-02 7.71e-01
Nuclear signaling by ERBB4 24 7.24e-01 4.16e-02 9.13e-01
Activation of AMPK downstream of NMDARs 20 7.48e-01 4.16e-02 9.24e-01
Dermatan sulfate biosynthesis 6 8.61e-01 4.13e-02 9.57e-01
Innate Immune System 966 3.08e-02 -4.11e-02 2.90e-01
RAC3 GTPase cycle 86 5.11e-01 -4.10e-02 8.01e-01
Late endosomal microautophagy 30 6.99e-01 -4.07e-02 9.01e-01
Advanced glycosylation endproduct receptor signaling 12 8.07e-01 -4.07e-02 9.42e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 8.63e-01 -4.06e-02 9.57e-01
Regulation of TP53 Activity 151 3.91e-01 -4.05e-02 7.36e-01
RSK activation 7 8.54e-01 -4.03e-02 9.57e-01
Regulation of FZD by ubiquitination 15 7.87e-01 4.02e-02 9.34e-01
Mitochondrial tRNA aminoacylation 21 7.50e-01 4.02e-02 9.24e-01
SARS-CoV-1 modulates host translation machinery 36 6.78e-01 4.00e-02 8.92e-01
NRIF signals cell death from the nucleus 15 7.89e-01 -3.99e-02 9.34e-01
G-protein activation 19 7.63e-01 -3.99e-02 9.29e-01
Keratan sulfate/keratin metabolism 27 7.20e-01 -3.99e-02 9.12e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 4.06e-01 -3.97e-02 7.45e-01
Regulation of HMOX1 expression and activity 5 8.78e-01 -3.96e-02 9.66e-01
Creatine metabolism 7 8.58e-01 -3.91e-02 9.57e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 7.02e-01 -3.91e-02 9.02e-01
MITF-M-dependent gene expression 81 5.44e-01 -3.90e-02 8.23e-01
Cristae formation 33 6.99e-01 3.88e-02 9.01e-01
Glycosaminoglycan metabolism 95 5.13e-01 3.88e-02 8.02e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 3.71e-01 3.88e-02 7.26e-01
Neutrophil degranulation 456 1.58e-01 -3.86e-02 5.10e-01
Neurotransmitter release cycle 38 6.83e-01 3.83e-02 8.93e-01
Circadian Clock 67 5.89e-01 -3.81e-02 8.44e-01
Signaling by NTRK3 (TRKC) 15 8.00e-01 -3.77e-02 9.39e-01
TAK1-dependent IKK and NF-kappa-B activation 43 6.69e-01 3.77e-02 8.87e-01
Insulin receptor recycling 24 7.49e-01 -3.77e-02 9.24e-01
Transcriptional activation of mitochondrial biogenesis 52 6.40e-01 -3.75e-02 8.68e-01
Hemostasis 553 1.34e-01 3.73e-02 4.81e-01
Gene Silencing by RNA 87 5.48e-01 -3.72e-02 8.27e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 7.48e-01 -3.71e-02 9.24e-01
Formation of ATP by chemiosmotic coupling 20 7.75e-01 3.70e-02 9.31e-01
Signaling by FGFR2 IIIa TM 18 7.86e-01 3.69e-02 9.34e-01
MET receptor recycling 9 8.49e-01 -3.67e-02 9.57e-01
Xenobiotics 9 8.49e-01 -3.67e-02 9.57e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 8.07e-01 3.64e-02 9.42e-01
PTK6 promotes HIF1A stabilization 6 8.78e-01 -3.61e-02 9.66e-01
TNFR1-induced NF-kappa-B signaling pathway 32 7.24e-01 3.60e-02 9.13e-01
Phase 4 - resting membrane potential 9 8.52e-01 -3.58e-02 9.57e-01
rRNA processing 213 3.70e-01 3.57e-02 7.26e-01
Disorders of Developmental Biology 12 8.31e-01 3.55e-02 9.54e-01
Disorders of Nervous System Development 12 8.31e-01 3.55e-02 9.54e-01
Loss of function of MECP2 in Rett syndrome 12 8.31e-01 3.55e-02 9.54e-01
Pervasive developmental disorders 12 8.31e-01 3.55e-02 9.54e-01
FLT3 Signaling 38 7.05e-01 -3.55e-02 9.03e-01
HCMV Early Events 84 5.74e-01 3.55e-02 8.41e-01
Pexophagy 10 8.46e-01 -3.54e-02 9.57e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 8.91e-01 -3.54e-02 9.68e-01
Phospholipase C-mediated cascade; FGFR2 8 8.63e-01 3.53e-02 9.57e-01
Signal transduction by L1 20 7.86e-01 -3.51e-02 9.34e-01
Acyl chain remodelling of PC 19 7.91e-01 -3.51e-02 9.34e-01
Sphingolipid metabolism 92 5.62e-01 -3.50e-02 8.38e-01
Nuclear events mediated by NFE2L2 81 5.90e-01 -3.47e-02 8.44e-01
Platelet activation, signaling and aggregation 219 3.77e-01 3.47e-02 7.31e-01
RAF-independent MAPK1/3 activation 21 7.83e-01 3.46e-02 9.34e-01
Peptide ligand-binding receptors 100 5.50e-01 -3.46e-02 8.27e-01
Peptide chain elongation 88 5.75e-01 3.46e-02 8.42e-01
IRS-mediated signalling 35 7.24e-01 -3.45e-02 9.13e-01
GPCR downstream signalling 396 2.40e-01 3.44e-02 6.13e-01
Phospholipid metabolism 182 4.23e-01 -3.44e-02 7.46e-01
Telomere C-strand (Lagging Strand) Synthesis 34 7.29e-01 -3.43e-02 9.16e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 8.44e-01 3.43e-02 9.57e-01
Formation of the cornified envelope 33 7.35e-01 3.40e-02 9.17e-01
Cation-coupled Chloride cotransporters 6 8.85e-01 3.40e-02 9.68e-01
Costimulation by the CD28 family 74 6.15e-01 3.38e-02 8.54e-01
Synthesis of PA 31 7.45e-01 -3.37e-02 9.23e-01
Role of phospholipids in phagocytosis 88 5.85e-01 3.37e-02 8.44e-01
SUMO E3 ligases SUMOylate target proteins 161 4.62e-01 -3.36e-02 7.71e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.31e-01 -3.35e-02 8.13e-01
Oxidative Stress Induced Senescence 77 6.11e-01 -3.35e-02 8.53e-01
WNT ligand biogenesis and trafficking 20 7.95e-01 -3.35e-02 9.36e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 7.72e-01 -3.35e-02 9.30e-01
Activation of Ca-permeable Kainate Receptor 8 8.70e-01 3.35e-02 9.61e-01
Ionotropic activity of kainate receptors 8 8.70e-01 3.35e-02 9.61e-01
G alpha (q) signalling events 139 5.00e-01 3.31e-02 7.93e-01
Signaling by ERBB2 44 7.05e-01 -3.30e-02 9.03e-01
Protein repair 6 8.89e-01 3.29e-02 9.68e-01
Influenza Infection 154 4.81e-01 -3.29e-02 7.84e-01
Signaling by TGFBR3 39 7.27e-01 -3.23e-02 9.16e-01
RHOU GTPase cycle 40 7.24e-01 -3.23e-02 9.13e-01
Glutathione conjugation 26 7.77e-01 -3.21e-02 9.32e-01
rRNA modification in the nucleus and cytosol 59 6.71e-01 3.19e-02 8.89e-01
KEAP1-NFE2L2 pathway 106 5.71e-01 -3.18e-02 8.40e-01
Vitamin B5 (pantothenate) metabolism 20 8.05e-01 -3.18e-02 9.42e-01
Metabolism of nucleotides 86 6.11e-01 -3.18e-02 8.53e-01
FCGR3A-mediated IL10 synthesis 99 5.85e-01 3.17e-02 8.44e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 8.56e-01 -3.16e-02 9.57e-01
SARS-CoV-2 modulates autophagy 11 8.57e-01 -3.15e-02 9.57e-01
Protein folding 83 6.23e-01 3.13e-02 8.57e-01
STING mediated induction of host immune responses 15 8.34e-01 3.12e-02 9.54e-01
Mitochondrial translation 96 5.98e-01 -3.11e-02 8.46e-01
Diseases associated with glycosaminoglycan metabolism 24 7.92e-01 3.11e-02 9.35e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 5.73e-01 -3.09e-02 8.41e-01
Death Receptor Signaling 145 5.21e-01 3.08e-02 8.05e-01
Nuclear Events (kinase and transcription factor activation) 54 6.95e-01 3.08e-02 8.99e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 7.90e-01 -3.08e-02 9.34e-01
Prostacyclin signalling through prostacyclin receptor 16 8.33e-01 3.05e-02 9.54e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 8.14e-01 3.04e-02 9.45e-01
TRAF3-dependent IRF activation pathway 13 8.50e-01 3.04e-02 9.57e-01
Sodium/Proton exchangers 7 8.89e-01 -3.04e-02 9.68e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 8.29e-01 -3.03e-02 9.54e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 7.67e-01 3.02e-02 9.29e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 6.94e-01 3.02e-02 8.99e-01
Cellular response to starvation 148 5.28e-01 3.00e-02 8.11e-01
Purine catabolism 16 8.37e-01 -2.98e-02 9.54e-01
Ion channel transport 136 5.49e-01 2.98e-02 8.27e-01
Glucose metabolism 76 6.55e-01 2.96e-02 8.77e-01
Signaling by Hedgehog 120 5.79e-01 -2.93e-02 8.44e-01
Trafficking of GluR2-containing AMPA receptors 11 8.66e-01 2.93e-02 9.59e-01
IRF3-mediated induction of type I IFN 12 8.61e-01 2.93e-02 9.57e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 6.93e-01 -2.92e-02 8.99e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 8.79e-01 2.92e-02 9.66e-01
Acyl chain remodelling of PG 11 8.67e-01 -2.92e-02 9.59e-01
Formation of axial mesoderm 6 9.02e-01 2.91e-02 9.74e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 6.93e-01 -2.90e-02 8.99e-01
Epigenetic regulation of gene expression 263 4.19e-01 -2.89e-02 7.46e-01
HATs acetylate histones 92 6.32e-01 2.89e-02 8.62e-01
Metabolism of water-soluble vitamins and cofactors 114 5.96e-01 -2.87e-02 8.45e-01
Induction of Cell-Cell Fusion 8 8.89e-01 -2.86e-02 9.68e-01
Eukaryotic Translation Elongation 93 6.34e-01 2.86e-02 8.63e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.76e-01 -2.85e-02 9.65e-01
Activation of SMO 14 8.54e-01 2.85e-02 9.57e-01
ERK/MAPK targets 22 8.18e-01 2.83e-02 9.46e-01
PTEN Regulation 126 5.85e-01 -2.82e-02 8.44e-01
Signaling by RNF43 mutants 7 8.97e-01 2.82e-02 9.71e-01
Beta-oxidation of very long chain fatty acids 11 8.72e-01 2.80e-02 9.62e-01
EPH-ephrin mediated repulsion of cells 42 7.56e-01 2.78e-02 9.26e-01
mRNA Capping 29 7.96e-01 -2.77e-02 9.37e-01
Cellular responses to stress 694 2.20e-01 -2.74e-02 5.85e-01
Ion transport by P-type ATPases 41 7.62e-01 -2.73e-02 9.29e-01
Leading Strand Synthesis 14 8.60e-01 -2.73e-02 9.57e-01
Polymerase switching 14 8.60e-01 -2.73e-02 9.57e-01
Unwinding of DNA 12 8.71e-01 -2.72e-02 9.61e-01
Diseases associated with glycosylation precursor biosynthesis 15 8.57e-01 2.70e-02 9.57e-01
GABA receptor activation 35 7.84e-01 2.68e-02 9.34e-01
SUMOylation of transcription cofactors 44 7.58e-01 2.68e-02 9.26e-01
Respiratory electron transport 149 5.73e-01 2.67e-02 8.41e-01
Biological oxidations 135 5.92e-01 2.67e-02 8.44e-01
FGFR2c ligand binding and activation 5 9.18e-01 -2.65e-02 9.83e-01
Signaling by Non-Receptor Tyrosine Kinases 47 7.54e-01 -2.64e-02 9.25e-01
Signaling by PTK6 47 7.54e-01 -2.64e-02 9.25e-01
Lysosome Vesicle Biogenesis 32 7.97e-01 2.62e-02 9.37e-01
SUMOylation of chromatin organization proteins 57 7.32e-01 -2.62e-02 9.17e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 7.13e-01 -2.61e-02 9.08e-01
Neurotransmitter receptors and postsynaptic signal transmission 132 6.05e-01 2.61e-02 8.51e-01
Chaperonin-mediated protein folding 77 6.95e-01 2.58e-02 8.99e-01
Unfolded Protein Response (UPR) 84 6.83e-01 2.57e-02 8.93e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 7.38e-01 2.56e-02 9.19e-01
Regulation of expression of SLITs and ROBOs 149 5.91e-01 -2.55e-02 8.44e-01
HCMV Late Events 67 7.18e-01 2.55e-02 9.11e-01
FCGR3A-mediated phagocytosis 121 6.29e-01 -2.54e-02 8.61e-01
Leishmania phagocytosis 121 6.29e-01 -2.54e-02 8.61e-01
Parasite infection 121 6.29e-01 -2.54e-02 8.61e-01
TCF dependent signaling in response to WNT 151 5.96e-01 -2.50e-02 8.45e-01
SLBP independent Processing of Histone Pre-mRNAs 10 8.91e-01 -2.49e-02 9.68e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 6.51e-01 -2.49e-02 8.75e-01
HCMV Infection 106 6.59e-01 2.48e-02 8.79e-01
Metabolic disorders of biological oxidation enzymes 23 8.38e-01 -2.46e-02 9.54e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 8.83e-01 2.44e-02 9.68e-01
Sensory Perception 188 5.66e-01 2.43e-02 8.40e-01
Mitochondrial translation initiation 90 6.91e-01 -2.43e-02 8.98e-01
Cellular responses to stimuli 776 2.52e-01 -2.42e-02 6.27e-01
Cell-Cell communication 108 6.64e-01 2.42e-02 8.84e-01
Oncogenic MAPK signaling 75 7.19e-01 -2.40e-02 9.12e-01
MET activates RAS signaling 10 8.96e-01 2.38e-02 9.70e-01
SLC transporter disorders 75 7.24e-01 -2.36e-02 9.13e-01
Endogenous sterols 17 8.66e-01 -2.36e-02 9.59e-01
Meiotic synapsis 43 7.90e-01 2.34e-02 9.34e-01
SOS-mediated signalling 7 9.15e-01 2.34e-02 9.83e-01
Hedgehog ‘off’ state 91 7.00e-01 -2.34e-02 9.01e-01
NADE modulates death signalling 5 9.28e-01 -2.33e-02 9.84e-01
Lysine catabolism 10 8.99e-01 2.31e-02 9.72e-01
Polymerase switching on the C-strand of the telomere 26 8.39e-01 2.30e-02 9.54e-01
IRS-related events triggered by IGF1R 36 8.12e-01 -2.30e-02 9.44e-01
Inflammasomes 21 8.56e-01 -2.29e-02 9.57e-01
Interleukin-4 and Interleukin-13 signaling 89 7.10e-01 -2.28e-02 9.07e-01
RHO GTPases activate PKNs 46 7.89e-01 -2.28e-02 9.34e-01
Carnitine shuttle 12 8.92e-01 2.26e-02 9.68e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 8.46e-01 -2.25e-02 9.57e-01
Signaling by NOTCH 173 6.10e-01 -2.25e-02 8.53e-01
rRNA processing in the mitochondrion 24 8.50e-01 -2.23e-02 9.57e-01
FGFR3 ligand binding and activation 5 9.32e-01 -2.22e-02 9.85e-01
FGFR3c ligand binding and activation 5 9.32e-01 -2.22e-02 9.85e-01
Inositol phosphate metabolism 42 8.04e-01 2.21e-02 9.41e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 8.56e-01 2.19e-02 9.57e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 9.33e-01 2.18e-02 9.85e-01
Glycerophospholipid biosynthesis 104 7.01e-01 2.18e-02 9.01e-01
RNA Polymerase I Transcription Termination 30 8.36e-01 2.18e-02 9.54e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 74 7.50e-01 2.14e-02 9.24e-01
Telomere Extension By Telomerase 23 8.59e-01 2.13e-02 9.57e-01
Extra-nuclear estrogen signaling 65 7.69e-01 -2.10e-02 9.30e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 8.38e-01 -2.09e-02 9.54e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 8.93e-01 -2.08e-02 9.68e-01
Phosphorylation of CD3 and TCR zeta chains 27 8.51e-01 -2.08e-02 9.57e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 7.42e-01 -2.08e-02 9.22e-01
Downstream signal transduction 27 8.54e-01 -2.05e-02 9.57e-01
Activation of gene expression by SREBF (SREBP) 42 8.18e-01 -2.05e-02 9.46e-01
Signaling by ERBB2 TMD/JMD mutants 17 8.84e-01 2.04e-02 9.68e-01
Transferrin endocytosis and recycling 26 8.58e-01 2.03e-02 9.57e-01
Miscellaneous transport and binding events 20 8.76e-01 2.01e-02 9.65e-01
RHO GTPases activate KTN1 11 9.08e-01 -2.00e-02 9.79e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 8.15e-01 -2.00e-02 9.45e-01
Respiratory syncytial virus (RSV) attachment and entry 17 8.87e-01 -1.99e-02 9.68e-01
FCGR activation 76 7.65e-01 1.98e-02 9.29e-01
UCH proteinases 73 7.70e-01 -1.98e-02 9.30e-01
Potential therapeutics for SARS 148 6.79e-01 1.97e-02 8.92e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 8.89e-01 1.96e-02 9.68e-01
Adipogenesis 95 7.42e-01 1.96e-02 9.22e-01
Surfactant metabolism 20 8.80e-01 -1.95e-02 9.66e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 8.87e-01 -1.93e-02 9.68e-01
Centrosome maturation 81 7.66e-01 -1.92e-02 9.29e-01
Recruitment of mitotic centrosome proteins and complexes 81 7.66e-01 -1.92e-02 9.29e-01
Mitochondrial biogenesis 91 7.53e-01 -1.91e-02 9.24e-01
Mitochondrial calcium ion transport 22 8.78e-01 1.89e-02 9.66e-01
Rab regulation of trafficking 122 7.18e-01 -1.89e-02 9.11e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 8.63e-01 -1.89e-02 9.57e-01
Mitochondrial translation termination 90 7.58e-01 -1.88e-02 9.26e-01
Signal amplification 28 8.65e-01 -1.86e-02 9.59e-01
Metabolism of steroid hormones 21 8.83e-01 1.85e-02 9.68e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 9.44e-01 1.83e-02 9.87e-01
TGFBR3 PTM regulation 10 9.21e-01 -1.81e-02 9.83e-01
Platelet degranulation 104 7.52e-01 1.79e-02 9.24e-01
G alpha (i) signalling events 196 6.67e-01 1.78e-02 8.86e-01
Interactions of Vpr with host cellular proteins 37 8.51e-01 -1.78e-02 9.57e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 9.45e-01 1.78e-02 9.88e-01
Zinc influx into cells by the SLC39 gene family 9 9.27e-01 1.77e-02 9.84e-01
Attachment and Entry 9694614 13 9.12e-01 1.77e-02 9.82e-01
Synthesis of UDP-N-acetyl-glucosamine 8 9.31e-01 1.76e-02 9.85e-01
PKMTs methylate histone lysines 42 8.46e-01 1.73e-02 9.57e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 8.72e-01 1.73e-02 9.62e-01
ADP signalling through P2Y purinoceptor 1 21 8.91e-01 1.73e-02 9.68e-01
Transport of small molecules 548 4.90e-01 1.72e-02 7.89e-01
Iron uptake and transport 52 8.30e-01 1.72e-02 9.54e-01
FCERI mediated Ca+2 mobilization 92 7.78e-01 -1.70e-02 9.33e-01
Signaling by Receptor Tyrosine Kinases 443 5.40e-01 1.70e-02 8.20e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 9.23e-01 -1.69e-02 9.83e-01
PIP3 activates AKT signaling 232 6.60e-01 -1.68e-02 8.80e-01
Bacterial Infection Pathways 65 8.16e-01 -1.67e-02 9.45e-01
Synthesis of substrates in N-glycan biosythesis 58 8.28e-01 1.65e-02 9.54e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 183 7.00e-01 1.65e-02 9.01e-01
FGFRL1 modulation of FGFR1 signaling 7 9.40e-01 -1.64e-02 9.87e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 7.64e-01 -1.63e-02 9.29e-01
Nonsense-Mediated Decay (NMD) 114 7.64e-01 -1.63e-02 9.29e-01
Anti-inflammatory response favouring Leishmania parasite infection 131 7.48e-01 1.63e-02 9.24e-01
Leishmania parasite growth and survival 131 7.48e-01 1.63e-02 9.24e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 8.84e-01 -1.59e-02 9.68e-01
Regulated proteolysis of p75NTR 11 9.28e-01 -1.58e-02 9.84e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 8.04e-01 1.58e-02 9.41e-01
Selenoamino acid metabolism 115 7.72e-01 -1.57e-02 9.30e-01
Transcriptional regulation by RUNX3 80 8.10e-01 -1.55e-02 9.44e-01
Attachment of GPI anchor to uPAR 7 9.44e-01 -1.55e-02 9.87e-01
Membrane binding and targetting of GAG proteins 13 9.24e-01 1.54e-02 9.83e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 9.24e-01 1.54e-02 9.83e-01
Transcriptional regulation by small RNAs 61 8.36e-01 1.54e-02 9.54e-01
Nucleotide Excision Repair 108 7.86e-01 -1.51e-02 9.34e-01
Nuclear events stimulated by ALK signaling in cancer 33 8.81e-01 -1.51e-02 9.67e-01
RUNX3 regulates WNT signaling 8 9.41e-01 1.50e-02 9.87e-01
Class A/1 (Rhodopsin-like receptors) 176 7.34e-01 -1.49e-02 9.17e-01
Signaling by Insulin receptor 63 8.38e-01 -1.48e-02 9.54e-01
DNA Double Strand Break Response 47 8.63e-01 -1.46e-02 9.57e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 9.23e-01 -1.45e-02 9.83e-01
RHOJ GTPase cycle 49 8.61e-01 -1.45e-02 9.57e-01
CD209 (DC-SIGN) signaling 20 9.11e-01 -1.45e-02 9.81e-01
RHOC GTPase cycle 71 8.33e-01 -1.44e-02 9.54e-01
Protein localization 157 7.56e-01 1.44e-02 9.26e-01
SHC1 events in ERBB2 signaling 17 9.22e-01 -1.38e-02 9.83e-01
GPCR ligand binding 241 7.15e-01 1.37e-02 9.10e-01
Organic cation transport 8 9.47e-01 1.35e-02 9.88e-01
Organic cation/anion/zwitterion transport 8 9.47e-01 1.35e-02 9.88e-01
Specification of primordial germ cells 6 9.55e-01 1.33e-02 9.92e-01
Deactivation of the beta-catenin transactivating complex 36 8.91e-01 -1.32e-02 9.68e-01
STAT3 nuclear events downstream of ALK signaling 11 9.40e-01 -1.31e-02 9.87e-01
Role of LAT2/NTAL/LAB on calcium mobilization 77 8.46e-01 1.28e-02 9.57e-01
Platelet homeostasis 69 8.54e-01 -1.28e-02 9.57e-01
Deposition of new CENPA-containing nucleosomes at the centromere 37 8.93e-01 -1.28e-02 9.68e-01
Nucleosome assembly 37 8.93e-01 -1.28e-02 9.68e-01
Cap-dependent Translation Initiation 118 8.11e-01 -1.28e-02 9.44e-01
Eukaryotic Translation Initiation 118 8.11e-01 -1.28e-02 9.44e-01
FCERI mediated MAPK activation 93 8.32e-01 1.27e-02 9.54e-01
STAT5 Activation 7 9.54e-01 -1.26e-02 9.91e-01
STAT5 activation downstream of FLT3 ITD mutants 9 9.49e-01 -1.24e-02 9.88e-01
Signaling by FGFR2 61 8.68e-01 -1.23e-02 9.60e-01
Glycolysis 68 8.61e-01 1.23e-02 9.57e-01
Vitamin D (calciferol) metabolism 10 9.47e-01 1.22e-02 9.88e-01
Attenuation phase 22 9.21e-01 1.22e-02 9.83e-01
Negative regulation of FGFR1 signaling 25 9.17e-01 -1.20e-02 9.83e-01
SLC-mediated transmembrane transport 171 7.90e-01 -1.18e-02 9.34e-01
Insulin receptor signalling cascade 40 8.99e-01 -1.16e-02 9.71e-01
Interleukin-7 signaling 21 9.27e-01 1.16e-02 9.84e-01
Cellular Senescence 142 8.13e-01 -1.15e-02 9.45e-01
Cell recruitment (pro-inflammatory response) 25 9.23e-01 1.12e-02 9.83e-01
Purinergic signaling in leishmaniasis infection 25 9.23e-01 1.12e-02 9.83e-01
Association of TriC/CCT with target proteins during biosynthesis 35 9.09e-01 -1.12e-02 9.79e-01
mTORC1-mediated signalling 24 9.25e-01 -1.11e-02 9.84e-01
GRB2 events in ERBB2 signaling 11 9.50e-01 1.10e-02 9.88e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.33e-01 1.08e-02 9.85e-01
Regulation of actin dynamics for phagocytic cup formation 123 8.37e-01 -1.07e-02 9.54e-01
Metabolism of vitamins and cofactors 163 8.14e-01 1.07e-02 9.45e-01
RAC1 GTPase cycle 170 8.11e-01 -1.06e-02 9.44e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 9.24e-01 -1.06e-02 9.83e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 9.24e-01 -1.06e-02 9.83e-01
RHOQ GTPase cycle 54 8.95e-01 1.04e-02 9.70e-01
MAPK1/MAPK3 signaling 227 7.88e-01 -1.04e-02 9.34e-01
Signaling by NTRK1 (TRKA) 102 8.56e-01 1.04e-02 9.57e-01
Extension of Telomeres 51 8.99e-01 -1.03e-02 9.71e-01
RHO GTPases activate IQGAPs 25 9.30e-01 1.01e-02 9.85e-01
Amino acid transport across the plasma membrane 24 9.32e-01 -1.00e-02 9.85e-01
Aerobic respiration and respiratory electron transport 245 7.90e-01 -9.88e-03 9.34e-01
FRS-mediated FGFR1 signaling 15 9.48e-01 -9.73e-03 9.88e-01
MET activates PTK2 signaling 21 9.39e-01 -9.59e-03 9.87e-01
Methionine salvage pathway 6 9.68e-01 9.48e-03 9.93e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 78 8.86e-01 9.38e-03 9.68e-01
RHOA GTPase cycle 138 8.53e-01 9.14e-03 9.57e-01
Ion homeostasis 40 9.20e-01 -9.14e-03 9.83e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 9.69e-01 9.04e-03 9.93e-01
Sphingolipid catabolism 11 9.59e-01 -9.00e-03 9.92e-01
Biotin transport and metabolism 11 9.59e-01 -8.98e-03 9.92e-01
Amine ligand-binding receptors 10 9.61e-01 8.86e-03 9.92e-01
CRMPs in Sema3A signaling 13 9.56e-01 8.82e-03 9.92e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 9.64e-01 8.79e-03 9.92e-01
L1CAM interactions 100 8.82e-01 8.56e-03 9.68e-01
Infection with Mycobacterium tuberculosis 26 9.41e-01 -8.35e-03 9.87e-01
Erythropoietin activates RAS 13 9.59e-01 -8.22e-03 9.92e-01
Viral mRNA Translation 88 8.95e-01 8.12e-03 9.70e-01
Signaling by BRAF and RAF1 fusions 59 9.16e-01 7.96e-03 9.83e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.35e-01 7.86e-03 9.86e-01
Metabolism of amino acids and derivatives 304 8.16e-01 -7.75e-03 9.45e-01
Netrin-1 signaling 34 9.38e-01 -7.73e-03 9.87e-01
Nervous system development 473 7.74e-01 -7.71e-03 9.31e-01
Signaling by Nuclear Receptors 210 8.53e-01 -7.44e-03 9.57e-01
Ephrin signaling 17 9.58e-01 7.32e-03 9.92e-01
Mitochondrial translation elongation 90 9.06e-01 -7.19e-03 9.78e-01
Pre-NOTCH Expression and Processing 63 9.22e-01 7.17e-03 9.83e-01
Signal Transduction 2034 6.01e-01 -7.04e-03 8.49e-01
SHC-mediated cascade:FGFR3 10 9.70e-01 6.98e-03 9.93e-01
IGF1R signaling cascade 37 9.42e-01 -6.86e-03 9.87e-01
Processive synthesis on the lagging strand 15 9.64e-01 -6.67e-03 9.92e-01
Formation of a pool of free 40S subunits 100 9.09e-01 6.64e-03 9.79e-01
Complex IV assembly 45 9.39e-01 6.63e-03 9.87e-01
ERBB2 Regulates Cell Motility 10 9.71e-01 6.61e-03 9.93e-01
Aflatoxin activation and detoxification 14 9.66e-01 6.58e-03 9.93e-01
Developmental Biology 906 7.40e-01 -6.52e-03 9.20e-01
PCP/CE pathway 74 9.23e-01 -6.52e-03 9.83e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.81e-01 -6.25e-03 9.93e-01
TNF signaling 56 9.38e-01 5.97e-03 9.87e-01
Opioid Signalling 74 9.30e-01 -5.93e-03 9.85e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 9.22e-01 5.83e-03 9.83e-01
Glycine degradation 7 9.79e-01 -5.81e-03 9.93e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 9.22e-01 5.68e-03 9.83e-01
Selenocysteine synthesis 92 9.26e-01 5.61e-03 9.84e-01
Eicosanoid ligand-binding receptors 13 9.73e-01 -5.48e-03 9.93e-01
TP53 Regulates Transcription of DNA Repair Genes 61 9.41e-01 5.48e-03 9.87e-01
MTOR signalling 39 9.53e-01 -5.48e-03 9.91e-01
Transcriptional Regulation by VENTX 38 9.53e-01 5.48e-03 9.91e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 9.48e-01 -5.47e-03 9.88e-01
Free fatty acids regulate insulin secretion 10 9.76e-01 -5.39e-03 9.93e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.61e-01 5.36e-03 9.92e-01
Laminin interactions 25 9.64e-01 5.14e-03 9.92e-01
Drug ADME 55 9.47e-01 -5.14e-03 9.88e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 9.71e-01 -5.05e-03 9.93e-01
Protein methylation 15 9.73e-01 -5.04e-03 9.93e-01
Metabolism 1808 7.24e-01 5.01e-03 9.13e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 9 9.79e-01 4.96e-03 9.93e-01
Defective EXT2 causes exostoses 2 9 9.79e-01 4.96e-03 9.93e-01
Eukaryotic Translation Termination 92 9.35e-01 4.91e-03 9.86e-01
Fatty acid metabolism 152 9.22e-01 -4.63e-03 9.83e-01
Rap1 signalling 14 9.77e-01 4.54e-03 9.93e-01
Signalling to RAS 19 9.74e-01 4.38e-03 9.93e-01
Transcriptional regulation of white adipocyte differentiation 77 9.50e-01 -4.14e-03 9.88e-01
Metabolism of cofactors 25 9.73e-01 -3.96e-03 9.93e-01
PI3K Cascade 31 9.70e-01 3.94e-03 9.93e-01
Post-translational protein phosphorylation 67 9.56e-01 3.91e-03 9.92e-01
Negative regulation of MAPK pathway 42 9.65e-01 -3.86e-03 9.93e-01
Pre-NOTCH Processing in Golgi 18 9.78e-01 3.82e-03 9.93e-01
Factors involved in megakaryocyte development and platelet production 128 9.42e-01 3.75e-03 9.87e-01
Influenza Viral RNA Transcription and Replication 135 9.40e-01 -3.75e-03 9.87e-01
Signaling by FGFR 73 9.59e-01 3.46e-03 9.92e-01
Pre-NOTCH Transcription and Translation 47 9.70e-01 -3.21e-03 9.93e-01
Myogenesis 20 9.80e-01 3.20e-03 9.93e-01
rRNA modification in the mitochondrion 8 9.87e-01 3.20e-03 9.94e-01
Response of Mtb to phagocytosis 22 9.80e-01 -3.06e-03 9.93e-01
Interleukin-10 signaling 36 9.76e-01 2.94e-03 9.93e-01
Synthesis of PC 23 9.81e-01 2.86e-03 9.93e-01
CASP8 activity is inhibited 11 9.87e-01 -2.77e-03 9.94e-01
Dimerization of procaspase-8 11 9.87e-01 -2.77e-03 9.94e-01
Regulation by c-FLIP 11 9.87e-01 -2.77e-03 9.94e-01
Chromosome Maintenance 102 9.64e-01 -2.56e-03 9.92e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 9.79e-01 -2.46e-03 9.93e-01
Recruitment of NuMA to mitotic centrosomes 88 9.70e-01 2.34e-03 9.93e-01
p38MAPK events 13 9.89e-01 2.19e-03 9.94e-01
Transcriptional regulation by RUNX1 170 9.62e-01 -2.13e-03 9.92e-01
RAF/MAP kinase cascade 222 9.57e-01 -2.10e-03 9.92e-01
Leishmania infection 210 9.61e-01 1.98e-03 9.92e-01
Parasitic Infection Pathways 210 9.61e-01 1.98e-03 9.92e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 9.88e-01 1.92e-03 9.94e-01
Response to elevated platelet cytosolic Ca2+ 108 9.74e-01 1.85e-03 9.93e-01
Regulation of endogenous retroelements 92 9.77e-01 1.76e-03 9.93e-01
Signaling by NTRKs 116 9.75e-01 1.67e-03 9.93e-01
Complex I biogenesis 66 9.83e-01 1.56e-03 9.93e-01
Formation of RNA Pol II elongation complex 56 9.84e-01 -1.54e-03 9.94e-01
RNA Polymerase II Transcription Elongation 56 9.84e-01 -1.54e-03 9.94e-01
ROS and RNS production in phagocytes 30 9.89e-01 -1.51e-03 9.94e-01
Negative regulation of the PI3K/AKT network 91 9.82e-01 -1.36e-03 9.93e-01
Viral Messenger RNA Synthesis 44 9.88e-01 1.33e-03 9.94e-01
Sema3A PAK dependent Axon repulsion 15 9.93e-01 -1.29e-03 9.97e-01
Intrinsic Pathway for Apoptosis 53 9.88e-01 1.24e-03 9.94e-01
Muscle contraction 142 9.82e-01 1.10e-03 9.93e-01
HDMs demethylate histones 22 9.93e-01 -1.08e-03 9.97e-01
Intracellular signaling by second messengers 264 9.76e-01 1.06e-03 9.93e-01
TNFR2 non-canonical NF-kB pathway 84 9.89e-01 9.02e-04 9.94e-01
RND2 GTPase cycle 36 9.94e-01 -7.75e-04 9.97e-01
SLC15A4:TASL-dependent IRF5 activation 6 9.98e-01 -6.90e-04 9.98e-01
Regulation of Expression and Function of Type II Classical Cadherins 23 9.97e-01 4.55e-04 9.98e-01
Regulation of Homotypic Cell-Cell Adhesion 23 9.97e-01 4.55e-04 9.98e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 9.96e-01 -3.20e-04 9.98e-01
Axon guidance 455 9.96e-01 -1.31e-04 9.98e-01
Semaphorin interactions 56 1.00e+00 -2.36e-05 1.00e+00


Detailed Gene set reports



Establishment of Sister Chromatid Cohesion
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 8.95e-06
s.dist -0.773
p.adjustANOVA 0.00123


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAG1 -10330
ESCO1 -10281
STAG2 -9820
SMC3 -9545
ESCO2 -9528
RAD21 -9515
PDS5A -9054
PDS5B -8844
WAPL -8421
SMC1A -3908
CDCA5 -1589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 -10330
ESCO1 -10281
STAG2 -9820
SMC3 -9545
ESCO2 -9528
RAD21 -9515
PDS5A -9054
PDS5B -8844
WAPL -8421
SMC1A -3908
CDCA5 -1589


Defective binding of VWF variant to GPIb:IX:V
set Defective binding of VWF variant to GPIb:IX:V
setSize 5
pANOVA 0.00376
s.dist 0.748
p.adjustANOVA 0.099


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA 9975
GP1BB 8936
GP9 8888
GP5 6427
VWF 5289

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All member genes
GeneID Gene Rank
GP1BA 9975
GP1BB 8936
GP9 8888
GP5 6427
VWF 5289


Enhanced binding of GP1BA variant to VWF multimer:collagen
set Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize 5
pANOVA 0.00376
s.dist 0.748
p.adjustANOVA 0.099


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA 9975
GP1BB 8936
GP9 8888
GP5 6427
VWF 5289

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All member genes
GeneID Gene Rank
GP1BA 9975
GP1BB 8936
GP9 8888
GP5 6427
VWF 5289


Defects of platelet adhesion to exposed collagen
set Defects of platelet adhesion to exposed collagen
setSize 6
pANOVA 0.00154
s.dist 0.747
p.adjustANOVA 0.0533


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA 9975
GP1BB 8936
GP9 8888
ADAMTS13 7798
GP5 6427
VWF 5289

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All member genes
GeneID Gene Rank
GP1BA 9975
GP1BB 8936
GP9 8888
ADAMTS13 7798
GP5 6427
VWF 5289


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.00444
s.dist 0.735
p.adjustANOVA 0.112


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 10156
ETHE1 9232
TST 8162
SUOX 7778
TSTD1 3470

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All member genes
GeneID Gene Rank
SLC25A10 10156
ETHE1 9232
TST 8162
SUOX 7778
TSTD1 3470


MET activates PI3K/AKT signaling
set MET activates PI3K/AKT signaling
setSize 5
pANOVA 0.00608
s.dist -0.708
p.adjustANOVA 0.142


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIK3CA -9858
HGF -9600
GAB1 -9160
PIK3R1 -8964
GRB2 -279

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All member genes
GeneID Gene Rank
PIK3CA -9858
HGF -9600
GAB1 -9160
PIK3R1 -8964
GRB2 -279


NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
set NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
setSize 5
pANOVA 0.00806
s.dist 0.684
p.adjustANOVA 0.163


Top enriched genes
Top 20 genes
GeneID Gene Rank
RXRB 8830
MYLIP 8815
RXRA 7574
NR1H2 5481
NR1H3 5413

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All member genes
GeneID Gene Rank
RXRB 8830
MYLIP 8815
RXRA 7574
NR1H2 5481
NR1H3 5413


Activation of caspases through apoptosome-mediated cleavage
set Activation of caspases through apoptosome-mediated cleavage
setSize 6
pANOVA 0.00432
s.dist -0.673
p.adjustANOVA 0.112


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460


Cohesin Loading onto Chromatin
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 0.000233
s.dist -0.672
p.adjustANOVA 0.0146


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAG1 -10330
NIPBL -9913
STAG2 -9820
SMC3 -9545
RAD21 -9515
PDS5A -9054
PDS5B -8844
WAPL -8421
SMC1A -3908
MAU2 7518

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 -10330
NIPBL -9913
STAG2 -9820
SMC3 -9545
RAD21 -9515
PDS5A -9054
PDS5B -8844
WAPL -8421
SMC1A -3908
MAU2 7518


ARMS-mediated activation
set ARMS-mediated activation
setSize 6
pANOVA 0.00525
s.dist -0.658
p.adjustANOVA 0.128


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAP1A -9800
NTRK1 -9342
YWHAB -7815
BRAF -7070
KIDINS220 -6559
CRK -1632

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAP1A -9800
NTRK1 -9342
YWHAB -7815
BRAF -7070
KIDINS220 -6559
CRK -1632


Negative regulation of TCF-dependent signaling by DVL-interacting proteins
set Negative regulation of TCF-dependent signaling by DVL-interacting proteins
setSize 5
pANOVA 0.0109
s.dist 0.657
p.adjustANOVA 0.183


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL3 10328
DVL1 9486
CCDC88C 8621
DVL2 8531
CXXC4 -2287

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DVL3 10328
DVL1 9486
CCDC88C 8621
DVL2 8531
CXXC4 -2287


Synthesis of PI
set Synthesis of PI
setSize 5
pANOVA 0.0126
s.dist 0.644
p.adjustANOVA 0.186


Top enriched genes
Top 20 genes
GeneID Gene Rank
PITPNM2 10443
PITPNM3 10155
PITPNM1 7857
CDIPT 7394
CDS1 -1876

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All member genes
GeneID Gene Rank
PITPNM2 10443
PITPNM3 10155
PITPNM1 7857
CDIPT 7394
CDS1 -1876


Neurotransmitter clearance
set Neurotransmitter clearance
setSize 6
pANOVA 0.00872
s.dist 0.618
p.adjustANOVA 0.172


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC22A1 9664
ALDH2 8384
COMT 7007
MAOA 5037
SLC6A4 4996
LRTOMT 4048

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC22A1 9664
ALDH2 8384
COMT 7007
MAOA 5037
SLC6A4 4996
LRTOMT 4048


Fructose metabolism
set Fructose metabolism
setSize 7
pANOVA 0.00512
s.dist 0.611
p.adjustANOVA 0.128


Top enriched genes
Top 20 genes
GeneID Gene Rank
TKFC 9783
GLYCTK 9606
ALDH1A1 8954
AKR1B1 7201
KHK 6912
SORD 6072
ALDOB -3421

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TKFC 9783
GLYCTK 9606
ALDH1A1 8954
AKR1B1 7201
KHK 6912
SORD 6072
ALDOB -3421


Fructose catabolism
set Fructose catabolism
setSize 5
pANOVA 0.0194
s.dist 0.604
p.adjustANOVA 0.232


Top enriched genes
Top 20 genes
GeneID Gene Rank
TKFC 9783
GLYCTK 9606
ALDH1A1 8954
KHK 6912
ALDOB -3421

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TKFC 9783
GLYCTK 9606
ALDH1A1 8954
KHK 6912
ALDOB -3421


ALK mutants bind TKIs
set ALK mutants bind TKIs
setSize 11
pANOVA 0.000832
s.dist -0.582
p.adjustANOVA 0.0355


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPM1B -10322
HIP1 -9803
EML4 -9434
PRKAR1A -9107
CLTC -8632
STRN -7458
BIRC6 -7200
EIF2AK3 -7180
NPM1 -4995
BCL11A -4928
FN1 10573

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPM1B -10322
HIP1 -9803
EML4 -9434
PRKAR1A -9107
CLTC -8632
STRN -7458
BIRC6 -7200
EIF2AK3 -7180
NPM1 -4995
BCL11A -4928
FN1 10573


Wax and plasmalogen biosynthesis
set Wax and plasmalogen biosynthesis
setSize 5
pANOVA 0.0265
s.dist -0.573
p.adjustANOVA 0.271


Top enriched genes
Top 20 genes
GeneID Gene Rank
FAR1 -9979
GNPAT -9969
AGPS -8424
DHRS7B -1191
FAR2 -1107

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FAR1 -9979
GNPAT -9969
AGPS -8424
DHRS7B -1191
FAR2 -1107


Synthesis of PIPs at the late endosome membrane
set Synthesis of PIPs at the late endosome membrane
setSize 11
pANOVA 0.00127
s.dist -0.561
p.adjustANOVA 0.0471


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTM1 -9796
MTMR4 -9613
PIK3C3 -9356
MTMR2 -8225
PIK3C2A -7677
FIG4 -7621
MTMR9 -7102
PIKFYVE -6981
MTMR7 -5446
PIK3R4 -3463
VAC14 9240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTM1 -9796
MTMR4 -9613
PIK3C3 -9356
MTMR2 -8225
PIK3C2A -7677
FIG4 -7621
MTMR9 -7102
PIKFYVE -6981
MTMR7 -5446
PIK3R4 -3463
VAC14 9240


Regulation of IFNG signaling
set Regulation of IFNG signaling
setSize 14
pANOVA 0.000342
s.dist -0.553
p.adjustANOVA 0.0199


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAT1 -10588
SUMO1 -9355
JAK1 -8947
PTPN2 -8906
JAK2 -8416
PTPN11 -7765
PTPN1 -7133
IFNG -6815
SOCS3 -5235
IFNGR1 -4379
IFNGR2 -4019
SOCS1 -2855
PIAS1 -1929
PTPN6 3528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT1 -10588
SUMO1 -9355
JAK1 -8947
PTPN2 -8906
JAK2 -8416
PTPN11 -7765
PTPN1 -7133
IFNG -6815
SOCS3 -5235
IFNGR1 -4379
IFNGR2 -4019
SOCS1 -2855
PIAS1 -1929
PTPN6 3528


NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
set NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
setSize 5
pANOVA 0.0327
s.dist 0.551
p.adjustANOVA 0.299


Top enriched genes
Top 20 genes
GeneID Gene Rank
RXRB 8830
RXRA 7574
NR1H2 5481
NR1H3 5413
PLIN1 1766

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RXRB 8830
RXRA 7574
NR1H2 5481
NR1H3 5413
PLIN1 1766


Regulation of TP53 Activity through Association with Co-factors
set Regulation of TP53 Activity through Association with Co-factors
setSize 11
pANOVA 0.00173
s.dist 0.546
p.adjustANOVA 0.0563


Top enriched genes
Top 20 genes
GeneID Gene Rank
TP73 10519
AKT2 10312
AKT1 10277
PPP1R13L 9716
PPP1R13B 9108
TP53 8551
ZNF385A 8473
BANP 5954
AKT3 1491
TP53BP2 -3441
PHF20 -7730

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TP73 10519
AKT2 10312
AKT1 10277
PPP1R13L 9716
PPP1R13B 9108
TP53 8551
ZNF385A 8473
BANP 5954
AKT3 1491
TP53BP2 -3441
PHF20 -7730


SMAC (DIABLO) binds to IAPs
set SMAC (DIABLO) binds to IAPs
setSize 7
pANOVA 0.0129
s.dist -0.543
p.adjustANOVA 0.186


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460
DIABLO 2463

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460
DIABLO 2463


SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
set SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
setSize 7
pANOVA 0.0129
s.dist -0.543
p.adjustANOVA 0.186


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460
DIABLO 2463

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460
DIABLO 2463


SMAC, XIAP-regulated apoptotic response
set SMAC, XIAP-regulated apoptotic response
setSize 7
pANOVA 0.0129
s.dist -0.543
p.adjustANOVA 0.186


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460
DIABLO 2463

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -10585
APAF1 -8054
CASP7 -7890
XIAP -7151
CYCS -7020
CASP9 -2460
DIABLO 2463


Toxicity of botulinum toxin type D (botD)
set Toxicity of botulinum toxin type D (botD)
setSize 5
pANOVA 0.0365
s.dist 0.54
p.adjustANOVA 0.301


Top enriched genes
Top 20 genes
GeneID Gene Rank
VAMP1 10294
SV2A 7696
VAMP2 7647
SV2B 4320
SV2C -1499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VAMP1 10294
SV2A 7696
VAMP2 7647
SV2B 4320
SV2C -1499


Toxicity of botulinum toxin type F (botF)
set Toxicity of botulinum toxin type F (botF)
setSize 5
pANOVA 0.0365
s.dist 0.54
p.adjustANOVA 0.301


Top enriched genes
Top 20 genes
GeneID Gene Rank
VAMP1 10294
SV2A 7696
VAMP2 7647
SV2B 4320
SV2C -1499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VAMP1 10294
SV2A 7696
VAMP2 7647
SV2B 4320
SV2C -1499


CDC6 association with the ORC:origin complex
set CDC6 association with the ORC:origin complex
setSize 8
pANOVA 0.00907
s.dist -0.533
p.adjustANOVA 0.174


Top enriched genes
Top 20 genes
GeneID Gene Rank
ORC5 -10209
ORC4 -9487
CDC6 -8839
ORC3 -6028
ORC2 -5295
ORC1 -4533
MCM8 -2808
ORC6 1561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC5 -10209
ORC4 -9487
CDC6 -8839
ORC3 -6028
ORC2 -5295
ORC1 -4533
MCM8 -2808
ORC6 1561


Defective factor IX causes hemophilia B
set Defective factor IX causes hemophilia B
setSize 6
pANOVA 0.0249
s.dist 0.529
p.adjustANOVA 0.263


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA 9975
GGCX 9687
GP1BB 8936
GP9 8888
GP5 6427
F8 -10497

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA 9975
GGCX 9687
GP1BB 8936
GP9 8888
GP5 6427
F8 -10497


Mitotic Telophase/Cytokinesis
set Mitotic Telophase/Cytokinesis
setSize 13
pANOVA 0.00107
s.dist -0.524
p.adjustANOVA 0.0437


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAG1 -10330
NIPBL -9913
STAG2 -9820
SMC3 -9545
RAD21 -9515
PDS5A -9054
PDS5B -8844
WAPL -8421
KIF23 -7009
SMC1A -3908
KIF20A -1924
MAU2 7518
PLK1 7827

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 -10330
NIPBL -9913
STAG2 -9820
SMC3 -9545
RAD21 -9515
PDS5A -9054
PDS5B -8844
WAPL -8421
KIF23 -7009
SMC1A -3908
KIF20A -1924
MAU2 7518
PLK1 7827


Synthesis of 12-eicosatetraenoic acid derivatives
set Synthesis of 12-eicosatetraenoic acid derivatives
setSize 6
pANOVA 0.0263
s.dist 0.524
p.adjustANOVA 0.27


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX12 10329
GPX1 8602
ALOX12B 7375
GPX4 6228
ALOX15 4264
GPX2 -3690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX12 10329
GPX1 8602
ALOX12B 7375
GPX4 6228
ALOX15 4264
GPX2 -3690


Adenylate cyclase activating pathway
set Adenylate cyclase activating pathway
setSize 8
pANOVA 0.0107
s.dist 0.521
p.adjustANOVA 0.182


Top enriched genes
Top 20 genes
GeneID Gene Rank
ADCY5 9754
ADCY9 9152
ADCY6 8525
ADCY3 7397
ADCY7 6974
ADCY4 4222
GNAL 1536
ADCY2 -3637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADCY5 9754
ADCY9 9152
ADCY6 8525
ADCY3 7397
ADCY7 6974
ADCY4 4222
GNAL 1536
ADCY2 -3637


Diseases of Mismatch Repair (MMR)
set Diseases of Mismatch Repair (MMR)
setSize 5
pANOVA 0.0444
s.dist -0.519
p.adjustANOVA 0.326


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH2 -8510
MSH6 -5515
PMS2 -5210
MLH1 -5044
MSH3 -3527

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH2 -8510
MSH6 -5515
PMS2 -5210
MLH1 -5044
MSH3 -3527


OAS antiviral response
set OAS antiviral response
setSize 8
pANOVA 0.0111
s.dist -0.518
p.adjustANOVA 0.183


Top enriched genes
Top 20 genes
GeneID Gene Rank
OAS2 -10626
OAS1 -10486
OAS3 -10436
RNASEL -10158
OASL -8310
ABCE1 -5817
PDE12 1687
FLNA 9720

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OAS2 -10626
OAS1 -10486
OAS3 -10436
RNASEL -10158
OASL -8310
ABCE1 -5817
PDE12 1687
FLNA 9720


SUMO is proteolytically processed
set SUMO is proteolytically processed
setSize 6
pANOVA 0.0279
s.dist -0.518
p.adjustANOVA 0.276


Top enriched genes
Top 20 genes
GeneID Gene Rank
SUMO1 -9355
SENP2 -9201
SUMO2 -7983
SENP1 -6385
SENP5 -6101
SUMO3 5714

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUMO1 -9355
SENP2 -9201
SUMO2 -7983
SENP1 -6385
SENP5 -6101
SUMO3 5714


Cobalamin (Cbl) metabolism
set Cobalamin (Cbl) metabolism
setSize 7
pANOVA 0.0177
s.dist -0.518
p.adjustANOVA 0.22


Top enriched genes
Top 20 genes
GeneID Gene Rank
MMUT -10178
MMAA -9370
MMADHC -9324
MMACHC -4576
MTRR -4561
MTR -4174
MMAB 3359

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMUT -10178
MMAA -9370
MMADHC -9324
MMACHC -4576
MTRR -4561
MTR -4174
MMAB 3359


Transcriptional regulation of testis differentiation
set Transcriptional regulation of testis differentiation
setSize 5
pANOVA 0.0456
s.dist 0.516
p.adjustANOVA 0.328


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTGDS 9245
FGF9 8603
ZFPM2 6606
AMH 5437
WNT4 -2698

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGDS 9245
FGF9 8603
ZFPM2 6606
AMH 5437
WNT4 -2698


Synthesis of GDP-mannose
set Synthesis of GDP-mannose
setSize 6
pANOVA 0.03
s.dist 0.512
p.adjustANOVA 0.289


Top enriched genes
Top 20 genes
GeneID Gene Rank
PMM2 9296
GMPPA 6749
GMPPB 6655
PMM1 6066
MPI 4476
HK1 -912

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PMM2 9296
GMPPA 6749
GMPPB 6655
PMM1 6066
MPI 4476
HK1 -912


Formation of the active cofactor, UDP-glucuronate
set Formation of the active cofactor, UDP-glucuronate
setSize 5
pANOVA 0.0479
s.dist -0.511
p.adjustANOVA 0.337


Top enriched genes
Top 20 genes
GeneID Gene Rank
UGP2 -10373
UGDH -6961
UXS1 -6422
SLC35D1 -3796
SLC35D2 182

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UGP2 -10373
UGDH -6961
UXS1 -6422
SLC35D1 -3796
SLC35D2 182


Degradation of cysteine and homocysteine
set Degradation of cysteine and homocysteine
setSize 12
pANOVA 0.00251
s.dist 0.504
p.adjustANOVA 0.0714


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 10156
ETHE1 9232
MPST 8399
CSAD 8187
TST 8162
SUOX 7778
ADO 3860
GOT2 3740
TSTD1 3470
GADL1 1514
TXN2 791
CTH -1626

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 10156
ETHE1 9232
MPST 8399
CSAD 8187
TST 8162
SUOX 7778
ADO 3860
GOT2 3740
TSTD1 3470
GADL1 1514
TXN2 791
CTH -1626


E2F-enabled inhibition of pre-replication complex formation
set E2F-enabled inhibition of pre-replication complex formation
setSize 9
pANOVA 0.00889
s.dist -0.504
p.adjustANOVA 0.172


Top enriched genes
Top 20 genes
GeneID Gene Rank
ORC5 -10209
CDK1 -9871
ORC4 -9487
ORC3 -6028
ORC2 -5295
ORC1 -4533
MCM8 -2808
CCNB1 -1887
ORC6 1561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC5 -10209
CDK1 -9871
ORC4 -9487
ORC3 -6028
ORC2 -5295
ORC1 -4533
MCM8 -2808
CCNB1 -1887
ORC6 1561


RUNX1 regulates transcription of genes involved in BCR signaling
set RUNX1 regulates transcription of genes involved in BCR signaling
setSize 6
pANOVA 0.0328
s.dist -0.503
p.adjustANOVA 0.299


Top enriched genes
Top 20 genes
GeneID Gene Rank
ELF1 -10231
ELF2 -9744
CBFB -8903
RUNX1 -7086
PAX5 -2227
BLK 5844

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELF1 -10231
ELF2 -9744
CBFB -8903
RUNX1 -7086
PAX5 -2227
BLK 5844


Small interfering RNA (siRNA) biogenesis
set Small interfering RNA (siRNA) biogenesis
setSize 9
pANOVA 0.0106
s.dist -0.492
p.adjustANOVA 0.182


Top enriched genes
Top 20 genes
GeneID Gene Rank
TSNAX -9494
DICER1 -9063
TSN -8773
AGO4 -8661
PRKRA -8284
AGO3 -7782
AGO2 -4691
AGO1 710
TARBP2 8596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TSNAX -9494
DICER1 -9063
TSN -8773
AGO4 -8661
PRKRA -8284
AGO3 -7782
AGO2 -4691
AGO1 710
TARBP2 8596


Activation of the TFAP2 (AP-2) family of transcription factors
set Activation of the TFAP2 (AP-2) family of transcription factors
setSize 7
pANOVA 0.0245
s.dist 0.491
p.adjustANOVA 0.262


Top enriched genes
Top 20 genes
GeneID Gene Rank
TFAP2E 8812
CITED4 8643
WWOX 7952
CREBBP 6741
EP300 4820
CITED2 2515
YEATS4 -3310

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFAP2E 8812
CITED4 8643
WWOX 7952
CREBBP 6741
EP300 4820
CITED2 2515
YEATS4 -3310


Synthesis of PIPs at the early endosome membrane
set Synthesis of PIPs at the early endosome membrane
setSize 16
pANOVA 0.000713
s.dist -0.489
p.adjustANOVA 0.0334


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTMR10 -10337
MTM1 -9796
PI4K2B -9715
MTMR4 -9613
PIK3C3 -9356
MTMR2 -8225
PIK3C2A -7677
FIG4 -7621
PIKFYVE -6981
MTMR12 -6870
INPP4B -5277
INPP5F -4588
PIK3R4 -3463
INPP4A -1141
PI4K2A 7659
VAC14 9240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTMR10 -10337
MTM1 -9796
PI4K2B -9715
MTMR4 -9613
PIK3C3 -9356
MTMR2 -8225
PIK3C2A -7677
FIG4 -7621
PIKFYVE -6981
MTMR12 -6870
INPP4B -5277
INPP5F -4588
PIK3R4 -3463
INPP4A -1141
PI4K2A 7659
VAC14 9240


HDL remodeling
set HDL remodeling
setSize 6
pANOVA 0.0391
s.dist 0.486
p.adjustANOVA 0.312


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLTP 8479
LCAT 7981
APOE 7060
CETP 7001
ABCG1 407
LIPG -210

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLTP 8479
LCAT 7981
APOE 7060
CETP 7001
ABCG1 407
LIPG -210


Gain-of-function MRAS complexes activate RAF signaling
set Gain-of-function MRAS complexes activate RAF signaling
setSize 8
pANOVA 0.0189
s.dist -0.479
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB -10430
SHOC2 -10026
MRAS -9790
PPP1CC -8037
YWHAB -7815
BRAF -7070
RAF1 4570
ARAF 7509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB -10430
SHOC2 -10026
MRAS -9790
PPP1CC -8037
YWHAB -7815
BRAF -7070
RAF1 4570
ARAF 7509


SHOC2 M1731 mutant abolishes MRAS complex function
set SHOC2 M1731 mutant abolishes MRAS complex function
setSize 8
pANOVA 0.0189
s.dist -0.479
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB -10430
SHOC2 -10026
MRAS -9790
PPP1CC -8037
YWHAB -7815
BRAF -7070
RAF1 4570
ARAF 7509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB -10430
SHOC2 -10026
MRAS -9790
PPP1CC -8037
YWHAB -7815
BRAF -7070
RAF1 4570
ARAF 7509


Signaling by MRAS-complex mutants
set Signaling by MRAS-complex mutants
setSize 8
pANOVA 0.0189
s.dist -0.479
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB -10430
SHOC2 -10026
MRAS -9790
PPP1CC -8037
YWHAB -7815
BRAF -7070
RAF1 4570
ARAF 7509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB -10430
SHOC2 -10026
MRAS -9790
PPP1CC -8037
YWHAB -7815
BRAF -7070
RAF1 4570
ARAF 7509


RUNX3 regulates CDKN1A transcription
set RUNX3 regulates CDKN1A transcription
setSize 7
pANOVA 0.0323
s.dist 0.467
p.adjustANOVA 0.297


Top enriched genes
Top 20 genes
GeneID Gene Rank
TGFB1 10091
TP53 8551
RUNX3 8023
ZFHX3 5995
CDKN1A 5506
SMAD3 4940
SMAD4 -8688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGFB1 10091
TP53 8551
RUNX3 8023
ZFHX3 5995
CDKN1A 5506
SMAD3 4940
SMAD4 -8688


Regulation of PTEN mRNA translation
set Regulation of PTEN mRNA translation
setSize 12
pANOVA 0.00523
s.dist -0.466
p.adjustANOVA 0.128


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTEN -10357
CNOT6L -9679
VAPA -9270
AGO4 -8661
AGO3 -7782
TNRC6A -5204
TNRC6B -4986
AGO2 -4691
TNRC6C -1730
MIR25 -1445
AGO1 710
MOV10 3216

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTEN -10357
CNOT6L -9679
VAPA -9270
AGO4 -8661
AGO3 -7782
TNRC6A -5204
TNRC6B -4986
AGO2 -4691
TNRC6C -1730
MIR25 -1445
AGO1 710
MOV10 3216


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}
## Can't plot upregulated sets. Fewer than 5 found.

## [[1]]
## [[1]]$`UP genesets.Extracellular matrix organization`
##  [1] "ADAM15"  "ADAMTS2" "BMP1"    "CAPN10"  "CAPN15"  "COL11A2" "COL9A2" 
##  [8] "FN1"     "HTRA1"   "LAMB2"   "LAMC3"   "LTBP4"   "MMP8"    "MMP9"   
## [15] "NID2"    "PDGFB"   "TGFB1"   "TNXB"    "VTN"    
## 
## [[1]]$`UP genesets.Platelet Aggregation (Plug Formation)`
## [1] "AKT1"    "FN1"     "GP1BA"   "RAPGEF3" "RASGRP2"
## 
## [[1]]$`DOWN genesets.ALK mutants bind TKIs`
##  [1] "BCL11A"  "BIRC6"   "CLTC"    "EIF2AK3" "EML4"    "HIP1"    "NPM1"   
##  [8] "PPM1B"   "PRKAR1A" "STRN"   
## 
## [[1]]$`DOWN genesets.Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal`
##  [1] "AHCTF1"   "AURKB"    "B9D2"     "BIRC5"    "BUB1"     "BUB1B"   
##  [7] "BUB3"     "CDC20"    "CDCA8"    "CENPC"    "CENPE"    "CENPF"   
## [13] "CENPH"    "CENPI"    "CENPK"    "CENPL"    "CENPM"    "CENPN"   
## [19] "CENPO"    "CENPP"    "CENPQ"    "CENPU"    "CKAP5"    "CLASP1"  
## [25] "CLASP2"   "CLIP1"    "DSN1"     "DYNC1H1"  "DYNC1I1"  "DYNC1I2" 
## [31] "DYNC1LI1" "DYNC1LI2" "DYNLL1"   "DYNLL2"   "ERCC6L"   "INCENP"  
## [37] "ITGB3BP"  "KIF18A"   "KIF2A"    "KIF2C"    "KNL1"     "KNTC1"   
## [43] "MAD1L1"   "MAD2L1"   "MAPRE1"   "MIS12"    "NDC80"    "NDE1"    
## [49] "NDEL1"    "NSL1"     "NUDC"     "NUF2"     "NUP107"   "NUP133"  
## [55] "NUP160"   "NUP37"    "NUP43"    "NUP98"    "PAFAH1B1" "PLK1"    
## [61] "PMF1"     "PPP1CC"   "PPP2CA"   "PPP2CB"   "PPP2R1A"  "PPP2R1B" 
## [67] "PPP2R5A"  "PPP2R5B"  "PPP2R5C"  "PPP2R5D"  "PPP2R5E"  "RANBP2"  
## [73] "RANGAP1"  "RPS27"    "SEC13"    "SEH1L"    "SGO1"     "SGO2"    
## [79] "SKA1"     "SKA2"     "SPC24"    "SPDL1"    "TAOK1"    "XPO1"    
## [85] "ZW10"     "ZWILCH"   "ZWINT"   
## 
## [[1]]$`DOWN genesets.Amplification of signal from the kinetochores`
##  [1] "AHCTF1"   "AURKB"    "B9D2"     "BIRC5"    "BUB1"     "BUB1B"   
##  [7] "BUB3"     "CDC20"    "CDCA8"    "CENPC"    "CENPE"    "CENPF"   
## [13] "CENPH"    "CENPI"    "CENPK"    "CENPL"    "CENPM"    "CENPN"   
## [19] "CENPO"    "CENPP"    "CENPQ"    "CENPU"    "CKAP5"    "CLASP1"  
## [25] "CLASP2"   "CLIP1"    "DSN1"     "DYNC1H1"  "DYNC1I1"  "DYNC1I2" 
## [31] "DYNC1LI1" "DYNC1LI2" "DYNLL1"   "DYNLL2"   "ERCC6L"   "INCENP"  
## [37] "ITGB3BP"  "KIF18A"   "KIF2A"    "KIF2C"    "KNL1"     "KNTC1"   
## [43] "MAD1L1"   "MAD2L1"   "MAPRE1"   "MIS12"    "NDC80"    "NDE1"    
## [49] "NDEL1"    "NSL1"     "NUDC"     "NUF2"     "NUP107"   "NUP133"  
## [55] "NUP160"   "NUP37"    "NUP43"    "NUP98"    "PAFAH1B1" "PLK1"    
## [61] "PMF1"     "PPP1CC"   "PPP2CA"   "PPP2CB"   "PPP2R1A"  "PPP2R1B" 
## [67] "PPP2R5A"  "PPP2R5B"  "PPP2R5C"  "PPP2R5D"  "PPP2R5E"  "RANBP2"  
## [73] "RANGAP1"  "RPS27"    "SEC13"    "SEH1L"    "SGO1"     "SGO2"    
## [79] "SKA1"     "SKA2"     "SPC24"    "SPDL1"    "TAOK1"    "XPO1"    
## [85] "ZW10"     "ZWILCH"   "ZWINT"   
## 
## [[1]]$`DOWN genesets.Cohesin Loading onto Chromatin`
##  [1] "MAU2"  "NIPBL" "PDS5A" "PDS5B" "RAD21" "SMC1A" "SMC3"  "STAG1" "STAG2"
## [10] "WAPL" 
## 
## [[1]]$`DOWN genesets.Defective homologous recombination repair (HRR) due to BRCA2 loss of function`
##  [1] "ATM"      "ATR"      "ATRIP"    "BARD1"    "BLM"      "BRCA1"   
##  [7] "BRCA2"    "BRIP1"    "DNA2"     "EXO1"     "HUS1"     "KAT5"    
## [13] "MRE11"    "NBN"      "PALB2"    "RAD1"     "RAD17"    "RAD50"   
## [19] "RAD51"    "RAD51AP1" "RAD51B"   "RAD51C"   "RAD51D"   "RAD9B"   
## [25] "RBBP8"    "RFC2"     "RFC3"     "RFC4"     "RFC5"     "RHNO1"   
## [31] "RMI1"     "RMI2"     "RPA1"     "RPA2"     "RPA3"     "SEM1"    
## [37] "TOP3A"    "TOPBP1"   "WRN"      "XRCC2"   
## 
## [[1]]$`DOWN genesets.Diseases of DNA Double-Strand Break Repair`
##  [1] "ATM"      "ATR"      "ATRIP"    "BARD1"    "BLM"      "BRCA1"   
##  [7] "BRCA2"    "BRIP1"    "DNA2"     "EXO1"     "HUS1"     "KAT5"    
## [13] "MRE11"    "NBN"      "PALB2"    "RAD1"     "RAD17"    "RAD50"   
## [19] "RAD51"    "RAD51AP1" "RAD51B"   "RAD51C"   "RAD51D"   "RAD9B"   
## [25] "RBBP8"    "RFC2"     "RFC3"     "RFC4"     "RFC5"     "RHNO1"   
## [31] "RMI1"     "RMI2"     "RPA1"     "RPA2"     "RPA3"     "SEM1"    
## [37] "TOP3A"    "TOPBP1"   "WRN"      "XRCC2"   
## 
## [[1]]$`DOWN genesets.Establishment of Sister Chromatid Cohesion`
##  [1] "CDCA5" "ESCO1" "ESCO2" "PDS5A" "PDS5B" "RAD21" "SMC1A" "SMC3"  "STAG1"
## [10] "STAG2" "WAPL" 
## 
## [[1]]$`DOWN genesets.HDR through Single Strand Annealing (SSA)`
##  [1] "ABL1"   "ATM"    "ATR"    "ATRIP"  "BARD1"  "BLM"    "BRCA1"  "BRIP1" 
##  [9] "DNA2"   "ERCC4"  "EXO1"   "HUS1"   "KAT5"   "MRE11"  "NBN"    "RAD1"  
## [17] "RAD17"  "RAD50"  "RAD51"  "RAD52"  "RAD9B"  "RBBP8"  "RFC2"   "RFC3"  
## [25] "RFC4"   "RFC5"   "RHNO1"  "RMI1"   "RMI2"   "RPA1"   "RPA2"   "RPA3"  
## [33] "TOP3A"  "TOPBP1" "WRN"   
## 
## [[1]]$`DOWN genesets.Homologous DNA Pairing and Strand Exchange`
##  [1] "ATM"      "ATR"      "ATRIP"    "BARD1"    "BLM"      "BRCA1"   
##  [7] "BRCA2"    "BRIP1"    "CHEK1"    "DNA2"     "EXO1"     "HUS1"    
## [13] "KAT5"     "MRE11"    "NBN"      "PALB2"    "RAD1"     "RAD17"   
## [19] "RAD50"    "RAD51"    "RAD51AP1" "RAD51B"   "RAD51C"   "RAD51D"  
## [25] "RAD9B"    "RBBP8"    "RFC2"     "RFC3"     "RFC4"     "RFC5"    
## [31] "RHNO1"    "RMI1"     "RMI2"     "RPA1"     "RPA2"     "RPA3"    
## [37] "SEM1"     "TOP3A"    "TOPBP1"   "WRN"      "XRCC2"    "XRCC3"   
## 
## [[1]]$`DOWN genesets.ISG15 antiviral mechanism`
##  [1] "ARIH1"   "BECN1"   "EIF2AK2" "EIF4A1"  "EIF4A2"  "EIF4A3"  "EIF4E"  
##  [8] "EIF4E2"  "EIF4E3"  "EIF4G1"  "EIF4G2"  "EIF4G3"  "FLNB"    "HERC5"  
## [15] "IFIT1"   "IRF3"    "ISG15"   "JAK1"    "KPNA1"   "KPNA2"   "KPNA3"  
## [22] "KPNA4"   "KPNA5"   "KPNB1"   "MAPK3"   "MX1"     "MX2"     "NDC1"   
## [29] "NEDD4"   "NUP107"  "NUP133"  "NUP153"  "NUP155"  "NUP160"  "NUP205" 
## [36] "NUP210"  "NUP214"  "NUP35"   "NUP37"   "NUP42"   "NUP43"   "NUP50"  
## [43] "NUP54"   "NUP58"   "NUP88"   "NUP93"   "NUP98"   "PIN1"    "PLCG1"  
## [50] "POM121"  "POM121C" "PPM1B"   "RAE1"    "RANBP2"  "RPS27A"  "SEC13"  
## [57] "SEH1L"   "STAT1"   "TPR"     "TRIM25"  "UBA52"   "UBA7"    "UBB"    
## [64] "UBC"     "UBE2E1"  "UBE2L6"  "UBE2N"   "USP18"  
## 
## [[1]]$`DOWN genesets.Impaired BRCA2 binding to RAD51`
##  [1] "ATM"    "ATR"    "ATRIP"  "BARD1"  "BLM"    "BRCA1"  "BRCA2"  "BRIP1" 
##  [9] "DNA2"   "EXO1"   "HUS1"   "KAT5"   "MRE11"  "NBN"    "RAD1"   "RAD17" 
## [17] "RAD50"  "RAD51"  "RAD9B"  "RBBP8"  "RFC2"   "RFC3"   "RFC4"   "RFC5"  
## [25] "RHNO1"  "RMI1"   "RMI2"   "RPA1"   "RPA2"   "RPA3"   "SEM1"   "TOP3A" 
## [33] "TOPBP1" "WRN"   
## 
## [[1]]$`DOWN genesets.Interferon alpha/beta signaling`
##  [1] "ABCE1"   "ADAR"    "BST2"    "EGR1"    "EIF2AK2" "GBP2"    "HLA-A"  
##  [8] "HLA-B"   "HLA-C"   "HLA-E"   "HLA-F"   "HLA-H"   "IFI27"   "IFI35"  
## [15] "IFI6"    "IFIT1"   "IFIT2"   "IFIT3"   "IFIT5"   "IFITM1"  "IFITM2" 
## [22] "IFITM3"  "IFNAR1"  "IFNAR2"  "IP6K2"   "IRF1"    "IRF2"    "IRF3"   
## [29] "IRF4"    "IRF6"    "IRF7"    "IRF8"    "IRF9"    "ISG15"   "ISG20"  
## [36] "JAK1"    "KPNA1"   "KPNB1"   "MX1"     "MX2"     "OAS1"    "OAS2"   
## [43] "OAS3"    "OASL"    "PSMB8"   "PTPN1"   "PTPN11"  "PTPN6"   "RNASEL" 
## [50] "RPS27A"  "RSAD2"   "SAMHD1"  "SOCS1"   "SOCS3"   "STAT1"   "STAT2"  
## [57] "UBA52"   "UBB"     "UBC"     "USP18"   "XAF1"   
## 
## [[1]]$`DOWN genesets.M-decay: degradation of maternal mRNAs by maternally stored factors`
##  [1] "AGO2"     "BIRC5"    "CNOT1"    "CNOT10"   "CNOT11"   "CNOT2"   
##  [7] "CNOT3"    "CNOT4"    "CNOT6"    "CNOT6L"   "CNOT7"    "CNOT8"   
## [13] "CPEB1"    "DICER1"   "EIF4A1"   "EIF4A2"   "EIF4A3"   "EIF4B"   
## [19] "EIF4E"    "EIF4G1"   "ELL2"     "ELOC"     "KDM1B"    "KDM4B"   
## [25] "KDM4C"    "KDM5A"    "KDM5B"    "KPNA2"    "MED12L"   "MED13"   
## [31] "PABPC1"   "PABPN1L"  "PADI6"    "PAIP1"    "PAIP2"    "POLR2D"  
## [37] "RPS2"     "TET2"     "TNKS1BP1" "TUBB4B"   "ZFP36L2" 
## 
## [[1]]$`DOWN genesets.Mitotic Spindle Checkpoint`
##   [1] "AHCTF1"   "ANAPC1"   "ANAPC10"  "ANAPC11"  "ANAPC15"  "ANAPC16" 
##   [7] "ANAPC4"   "ANAPC5"   "ANAPC7"   "AURKB"    "B9D2"     "BIRC5"   
##  [13] "BUB1"     "BUB1B"    "BUB3"     "CDC16"    "CDC20"    "CDC23"   
##  [19] "CDC26"    "CDC27"    "CDCA8"    "CENPC"    "CENPE"    "CENPF"   
##  [25] "CENPH"    "CENPI"    "CENPK"    "CENPL"    "CENPM"    "CENPN"   
##  [31] "CENPO"    "CENPP"    "CENPQ"    "CENPU"    "CKAP5"    "CLASP1"  
##  [37] "CLASP2"   "CLIP1"    "DSN1"     "DYNC1H1"  "DYNC1I1"  "DYNC1I2" 
##  [43] "DYNC1LI1" "DYNC1LI2" "DYNLL1"   "DYNLL2"   "ERCC6L"   "INCENP"  
##  [49] "ITGB3BP"  "KIF18A"   "KIF2A"    "KIF2C"    "KNL1"     "KNTC1"   
##  [55] "MAD1L1"   "MAD2L1"   "MAPRE1"   "MIS12"    "NDC80"    "NDE1"    
##  [61] "NDEL1"    "NSL1"     "NUDC"     "NUF2"     "NUP107"   "NUP133"  
##  [67] "NUP160"   "NUP37"    "NUP43"    "NUP98"    "PAFAH1B1" "PLK1"    
##  [73] "PMF1"     "PPP1CC"   "PPP2CA"   "PPP2CB"   "PPP2R1A"  "PPP2R1B" 
##  [79] "PPP2R5A"  "PPP2R5B"  "PPP2R5C"  "PPP2R5D"  "PPP2R5E"  "RANBP2"  
##  [85] "RANGAP1"  "RPS27"    "SEC13"    "SEH1L"    "SGO1"     "SGO2"    
##  [91] "SKA1"     "SKA2"     "SPC24"    "SPDL1"    "TAOK1"    "UBE2C"   
##  [97] "UBE2D1"   "UBE2E1"   "UBE2S"    "XPO1"     "ZW10"     "ZWILCH"  
## [103] "ZWINT"   
## 
## [[1]]$`DOWN genesets.Mitotic Telophase/Cytokinesis`
##  [1] "KIF20A" "KIF23"  "MAU2"   "NIPBL"  "PDS5A"  "PDS5B"  "PLK1"   "RAD21" 
##  [9] "SMC1A"  "SMC3"   "STAG1"  "STAG2"  "WAPL"  
## 
## [[1]]$`DOWN genesets.Presynaptic phase of homologous DNA pairing and strand exchange`
##  [1] "ATM"    "ATR"    "ATRIP"  "BARD1"  "BLM"    "BRCA1"  "BRCA2"  "BRIP1" 
##  [9] "CHEK1"  "DNA2"   "EXO1"   "HUS1"   "KAT5"   "MRE11"  "NBN"    "RAD1"  
## [17] "RAD17"  "RAD50"  "RAD51"  "RAD51B" "RAD51C" "RAD51D" "RAD9B"  "RBBP8" 
## [25] "RFC2"   "RFC3"   "RFC4"   "RFC5"   "RHNO1"  "RMI1"   "RMI2"   "RPA1"  
## [33] "RPA2"   "RPA3"   "SEM1"   "TOP3A"  "TOPBP1" "WRN"    "XRCC2" 
## 
## [[1]]$`DOWN genesets.Regulation of IFNG signaling`
##  [1] "IFNG"   "IFNGR1" "IFNGR2" "JAK1"   "JAK2"   "PIAS1"  "PTPN1"  "PTPN11"
##  [9] "PTPN2"  "PTPN6"  "SOCS1"  "SOCS3"  "STAT1"  "SUMO1" 
## 
## [[1]]$`DOWN genesets.Resolution of Sister Chromatid Cohesion`
##   [1] "AHCTF1"   "AURKB"    "B9D2"     "BIRC5"    "BUB1"     "BUB1B"   
##   [7] "BUB3"     "CCNB1"    "CCNB2"    "CDC20"    "CDCA5"    "CDCA8"   
##  [13] "CDK1"     "CENPC"    "CENPE"    "CENPF"    "CENPH"    "CENPI"   
##  [19] "CENPK"    "CENPL"    "CENPM"    "CENPN"    "CENPO"    "CENPP"   
##  [25] "CENPQ"    "CENPU"    "CKAP5"    "CLASP1"   "CLASP2"   "CLIP1"   
##  [31] "DSN1"     "DYNC1H1"  "DYNC1I1"  "DYNC1I2"  "DYNC1LI1" "DYNC1LI2"
##  [37] "DYNLL1"   "DYNLL2"   "ERCC6L"   "HDAC8"    "INCENP"   "ITGB3BP" 
##  [43] "KIF18A"   "KIF2A"    "KIF2C"    "KNL1"     "KNTC1"    "MAD1L1"  
##  [49] "MAD2L1"   "MAPRE1"   "MIS12"    "NDC80"    "NDE1"     "NDEL1"   
##  [55] "NSL1"     "NUDC"     "NUF2"     "NUP107"   "NUP133"   "NUP160"  
##  [61] "NUP37"    "NUP43"    "NUP98"    "PAFAH1B1" "PDS5A"    "PDS5B"   
##  [67] "PLK1"     "PMF1"     "PPP1CC"   "PPP2CA"   "PPP2CB"   "PPP2R1A" 
##  [73] "PPP2R1B"  "PPP2R5A"  "PPP2R5B"  "PPP2R5C"  "PPP2R5D"  "PPP2R5E" 
##  [79] "RAD21"    "RANBP2"   "RANGAP1"  "RPS27"    "SEC13"    "SEH1L"   
##  [85] "SGO1"     "SGO2"     "SKA1"     "SKA2"     "SMC1A"    "SMC3"    
##  [91] "SPC24"    "SPDL1"    "STAG1"    "STAG2"    "TAOK1"    "TUBA1A"  
##  [97] "TUBA1B"   "TUBA1C"   "TUBA4A"   "TUBA4B"   "TUBA8"    "TUBB1"   
## [103] "TUBB2A"   "TUBB3"    "TUBB4A"   "TUBB4B"   "TUBB6"    "WAPL"    
## [109] "XPO1"     "ZW10"     "ZWILCH"   "ZWINT"   
## 
## [[1]]$`DOWN genesets.Synthesis of PIPs at the early endosome membrane`
##  [1] "FIG4"    "INPP4A"  "INPP4B"  "INPP5F"  "MTM1"    "MTMR10"  "MTMR12" 
##  [8] "MTMR2"   "MTMR4"   "PI4K2A"  "PI4K2B"  "PIK3C2A" "PIK3C3"  "PIK3R4" 
## [15] "PIKFYVE" "VAC14"  
## 
## [[1]]$`DOWN genesets.Synthesis of PIPs at the late endosome membrane`
##  [1] "FIG4"    "MTM1"    "MTMR2"   "MTMR4"   "MTMR7"   "MTMR9"   "PIK3C2A"
##  [8] "PIK3C3"  "PIK3R4"  "PIKFYVE" "VAC14"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report