date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 1.3629170
A1BG 0.2722541
A1BG-AS1 -0.1518099
A1CF -1.8974334
A2M 0.6716536
A2M-AS1 1.0774781

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21870
duplicated_genes_present 0
num_profile_genes_in_sets 8802
num_profile_genes_not_in_sets 13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1189
num_genesets_included 1536

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Biosynthesis of EPA-derived SPMs 6 2.57e-04 0.861 4.39e-03
Biosynthesis of Lipoxins (LX) 6 3.35e-04 0.845 5.25e-03
Biosynthesis of E-series 18(S)-resolvins 5 1.17e-03 0.838 1.35e-02
Protein repair 6 9.27e-04 0.781 1.15e-02
Cross-presentation of particulate exogenous antigens (phagosomes) 8 2.06e-04 0.758 3.64e-03
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.71e-03 0.707 2.41e-02
MECP2 regulates transcription of neuronal ligands 5 7.06e-03 -0.696 5.25e-02
Synthesis of 5-eicosatetraenoic acids 7 1.55e-03 0.691 1.65e-02
Fructose catabolism 5 1.04e-02 0.661 6.67e-02
Synthesis of 12-eicosatetraenoic acid derivatives 6 5.06e-03 0.661 4.00e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.27e-03 -0.658 1.43e-02
Signal attenuation 9 6.86e-04 0.653 9.06e-03
Interleukin-21 signaling 9 1.18e-03 -0.624 1.36e-02
OAS antiviral response 8 2.58e-03 -0.615 2.32e-02
Acetylcholine binding and downstream events 5 1.87e-02 -0.607 1.02e-01
Postsynaptic nicotinic acetylcholine receptors 5 1.87e-02 -0.607 1.02e-01
Defective LFNG causes SCDO3 5 2.68e-02 -0.572 1.30e-01
Histidine catabolism 7 8.90e-03 0.571 6.10e-02
NFE2L2 regulating inflammation associated genes 5 2.72e-02 -0.570 1.31e-01
Keratan sulfate degradation 9 3.19e-03 0.568 2.75e-02
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.02e-02 0.561 6.58e-02
Antimicrobial peptides 34 1.86e-08 0.557 1.43e-06
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.07e-02 -0.557 6.78e-02
Replacement of protamines by nucleosomes in the male pronucleus 13 5.31e-04 0.555 7.47e-03
Diseases of Mismatch Repair (MMR) 5 3.23e-02 -0.553 1.49e-01
Sulfide oxidation to sulfate 5 3.35e-02 0.549 1.52e-01
Cohesin Loading onto Chromatin 10 2.67e-03 -0.548 2.39e-02
RNA Polymerase I Promoter Opening 17 9.26e-05 0.548 2.30e-03
Metabolism of Angiotensinogen to Angiotensins 12 1.07e-03 0.545 1.27e-02
Mitotic Telophase/Cytokinesis 13 9.23e-04 -0.531 1.15e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.50e-02 0.528 1.24e-01
Fibronectin matrix formation 6 2.66e-02 0.523 1.29e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.11e-04 0.523 9.31e-03
Axonal growth inhibition (RHOA activation) 7 1.77e-02 0.518 9.80e-02
p75NTR regulates axonogenesis 7 1.77e-02 0.518 9.80e-02
Prostanoid ligand receptors 8 1.15e-02 0.516 7.04e-02
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.82e-02 -0.516 1.00e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 5.27e-07 -0.512 2.99e-05
HDL remodeling 6 3.01e-02 -0.511 1.41e-01
HDR through MMEJ (alt-NHEJ) 12 2.47e-03 -0.505 2.24e-02
Induction of Cell-Cell Fusion 8 1.37e-02 0.503 8.12e-02
TGFBR3 expression 20 1.04e-04 -0.501 2.50e-03
Common Pathway of Fibrin Clot Formation 13 1.77e-03 0.501 1.81e-02
Linoleic acid (LA) metabolism 7 2.23e-02 0.499 1.15e-01
Modulation by Mtb of host immune system 7 2.26e-02 0.498 1.15e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.50e-02 -0.497 8.76e-02
Regulation of NPAS4 mRNA translation 8 1.50e-02 -0.497 8.76e-02
Relaxin receptors 5 5.47e-02 0.496 2.11e-01
Phosphate bond hydrolysis by NTPDase proteins 5 5.74e-02 -0.491 2.19e-01
Regulation of NPAS4 gene expression 11 5.15e-03 -0.487 4.03e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Biosynthesis of EPA-derived SPMs 6 2.57e-04 8.61e-01 4.39e-03
Biosynthesis of Lipoxins (LX) 6 3.35e-04 8.45e-01 5.25e-03
Biosynthesis of E-series 18(S)-resolvins 5 1.17e-03 8.38e-01 1.35e-02
Protein repair 6 9.27e-04 7.81e-01 1.15e-02
Cross-presentation of particulate exogenous antigens (phagosomes) 8 2.06e-04 7.58e-01 3.64e-03
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.71e-03 7.07e-01 2.41e-02
MECP2 regulates transcription of neuronal ligands 5 7.06e-03 -6.96e-01 5.25e-02
Synthesis of 5-eicosatetraenoic acids 7 1.55e-03 6.91e-01 1.65e-02
Fructose catabolism 5 1.04e-02 6.61e-01 6.67e-02
Synthesis of 12-eicosatetraenoic acid derivatives 6 5.06e-03 6.61e-01 4.00e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.27e-03 -6.58e-01 1.43e-02
Signal attenuation 9 6.86e-04 6.53e-01 9.06e-03
Interleukin-21 signaling 9 1.18e-03 -6.24e-01 1.36e-02
OAS antiviral response 8 2.58e-03 -6.15e-01 2.32e-02
Acetylcholine binding and downstream events 5 1.87e-02 -6.07e-01 1.02e-01
Postsynaptic nicotinic acetylcholine receptors 5 1.87e-02 -6.07e-01 1.02e-01
Defective LFNG causes SCDO3 5 2.68e-02 -5.72e-01 1.30e-01
Histidine catabolism 7 8.90e-03 5.71e-01 6.10e-02
NFE2L2 regulating inflammation associated genes 5 2.72e-02 -5.70e-01 1.31e-01
Keratan sulfate degradation 9 3.19e-03 5.68e-01 2.75e-02
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.02e-02 5.61e-01 6.58e-02
Antimicrobial peptides 34 1.86e-08 5.57e-01 1.43e-06
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.07e-02 -5.57e-01 6.78e-02
Replacement of protamines by nucleosomes in the male pronucleus 13 5.31e-04 5.55e-01 7.47e-03
Diseases of Mismatch Repair (MMR) 5 3.23e-02 -5.53e-01 1.49e-01
Sulfide oxidation to sulfate 5 3.35e-02 5.49e-01 1.52e-01
Cohesin Loading onto Chromatin 10 2.67e-03 -5.48e-01 2.39e-02
RNA Polymerase I Promoter Opening 17 9.26e-05 5.48e-01 2.30e-03
Metabolism of Angiotensinogen to Angiotensins 12 1.07e-03 5.45e-01 1.27e-02
Mitotic Telophase/Cytokinesis 13 9.23e-04 -5.31e-01 1.15e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.50e-02 5.28e-01 1.24e-01
Fibronectin matrix formation 6 2.66e-02 5.23e-01 1.29e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.11e-04 5.23e-01 9.31e-03
Axonal growth inhibition (RHOA activation) 7 1.77e-02 5.18e-01 9.80e-02
p75NTR regulates axonogenesis 7 1.77e-02 5.18e-01 9.80e-02
Prostanoid ligand receptors 8 1.15e-02 5.16e-01 7.04e-02
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.82e-02 -5.16e-01 1.00e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 5.27e-07 -5.12e-01 2.99e-05
HDL remodeling 6 3.01e-02 -5.11e-01 1.41e-01
HDR through MMEJ (alt-NHEJ) 12 2.47e-03 -5.05e-01 2.24e-02
Induction of Cell-Cell Fusion 8 1.37e-02 5.03e-01 8.12e-02
TGFBR3 expression 20 1.04e-04 -5.01e-01 2.50e-03
Common Pathway of Fibrin Clot Formation 13 1.77e-03 5.01e-01 1.81e-02
Linoleic acid (LA) metabolism 7 2.23e-02 4.99e-01 1.15e-01
Modulation by Mtb of host immune system 7 2.26e-02 4.98e-01 1.15e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.50e-02 -4.97e-01 8.76e-02
Regulation of NPAS4 mRNA translation 8 1.50e-02 -4.97e-01 8.76e-02
Relaxin receptors 5 5.47e-02 4.96e-01 2.11e-01
Phosphate bond hydrolysis by NTPDase proteins 5 5.74e-02 -4.91e-01 2.19e-01
Regulation of NPAS4 gene expression 11 5.15e-03 -4.87e-01 4.03e-02
Activation of RAS in B cells 5 6.32e-02 -4.80e-01 2.35e-01
RUNX3 Regulates Immune Response and Cell Migration 5 6.34e-02 4.79e-01 2.35e-01
Post-transcriptional silencing by small RNAs 7 3.13e-02 -4.70e-01 1.45e-01
Fructose metabolism 7 3.13e-02 4.70e-01 1.45e-01
Establishment of Sister Chromatid Cohesion 11 7.33e-03 -4.67e-01 5.37e-02
Assembly of active LPL and LIPC lipase complexes 10 1.11e-02 4.64e-01 6.93e-02
ALK mutants bind TKIs 11 7.92e-03 -4.62e-01 5.72e-02
Diseases associated with surfactant metabolism 5 8.14e-02 4.50e-01 2.79e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 7.08e-03 4.49e-01 5.25e-02
Transport of connexons to the plasma membrane 12 7.08e-03 4.49e-01 5.25e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 5.13e-04 4.49e-01 7.34e-03
CD163 mediating an anti-inflammatory response 9 2.00e-02 4.48e-01 1.07e-01
ROBO receptors bind AKAP5 7 4.05e-02 -4.47e-01 1.72e-01
Scavenging by Class F Receptors 5 8.36e-02 -4.47e-01 2.82e-01
LTC4-CYSLTR mediated IL4 production 5 8.45e-02 -4.46e-01 2.84e-01
Regulation of NFE2L2 gene expression 8 2.98e-02 -4.44e-01 1.40e-01
Synthesis of PIPs at the early endosome membrane 16 2.14e-03 -4.43e-01 2.05e-02
RORA activates gene expression 18 1.15e-03 -4.42e-01 1.34e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.49e-05 -4.42e-01 5.51e-04
FGFR3 ligand binding and activation 5 8.73e-02 -4.41e-01 2.89e-01
FGFR3c ligand binding and activation 5 8.73e-02 -4.41e-01 2.89e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 2.26e-03 4.41e-01 2.10e-02
p75NTR recruits signalling complexes 12 8.34e-03 4.40e-01 5.93e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.73e-05 -4.39e-01 5.86e-04
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.73e-05 -4.39e-01 5.86e-04
Interleukin-9 signaling 8 3.25e-02 -4.37e-01 1.49e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 4.63e-02 -4.35e-01 1.88e-01
Erythrocytes take up oxygen and release carbon dioxide 7 4.66e-02 4.34e-01 1.88e-01
Uptake of dietary cobalamins into enterocytes 6 6.59e-02 -4.34e-01 2.38e-01
Disorders of Developmental Biology 12 9.36e-03 -4.33e-01 6.28e-02
Disorders of Nervous System Development 12 9.36e-03 -4.33e-01 6.28e-02
Loss of function of MECP2 in Rett syndrome 12 9.36e-03 -4.33e-01 6.28e-02
Pervasive developmental disorders 12 9.36e-03 -4.33e-01 6.28e-02
Defective binding of VWF variant to GPIb:IX:V 6 6.67e-02 4.32e-01 2.40e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 6 6.67e-02 4.32e-01 2.40e-01
Defective factor IX causes hemophilia B 6 6.79e-02 4.30e-01 2.43e-01
NR1H2 and NR1H3-mediated signaling 38 5.22e-06 -4.27e-01 2.24e-04
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.06e-02 4.26e-01 6.73e-02
Vpr-mediated nuclear import of PICs 34 1.72e-05 -4.26e-01 5.86e-04
Formation of ATP by chemiosmotic coupling 20 1.12e-03 4.21e-01 1.30e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.00e-02 4.18e-01 1.41e-01
Diseases of hemostasis 14 7.19e-03 4.15e-01 5.29e-02
Activation of BAD and translocation to mitochondria 15 5.87e-03 4.11e-01 4.51e-02
CYP2E1 reactions 5 1.12e-01 -4.11e-01 3.35e-01
Activation of RAC1 downstream of NMDARs 7 6.04e-02 4.10e-01 2.29e-01
RHO GTPases Activate NADPH Oxidases 22 1.02e-03 4.04e-01 1.23e-02
Erythrocytes take up carbon dioxide and release oxygen 11 2.04e-02 4.04e-01 1.08e-01
O2/CO2 exchange in erythrocytes 11 2.04e-02 4.04e-01 1.08e-01
Post-chaperonin tubulin folding pathway 18 3.06e-03 4.03e-01 2.66e-02
Interferon alpha/beta signaling 64 2.99e-08 -4.00e-01 2.21e-06
Regulation of MECP2 expression and activity 29 1.92e-04 -4.00e-01 3.50e-03
Crosslinking of collagen fibrils 13 1.33e-02 3.97e-01 7.89e-02
Regulation of ornithine decarboxylase (ODC) 38 2.40e-05 3.96e-01 7.96e-04
Zygotic genome activation (ZGA) 5 1.26e-01 -3.95e-01 3.61e-01
DNA methylation 18 3.95e-03 3.92e-01 3.31e-02
The canonical retinoid cycle in rods (twilight vision) 9 4.23e-02 3.91e-01 1.76e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.07e-04 -3.90e-01 2.53e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.97e-02 3.89e-01 1.06e-01
alpha-linolenic acid (ALA) metabolism 12 1.97e-02 3.89e-01 1.06e-01
PI-3K cascade:FGFR4 11 2.59e-02 -3.88e-01 1.26e-01
SUMOylation of SUMOylation proteins 35 7.12e-05 -3.88e-01 2.02e-03
Response to metal ions 6 9.99e-02 3.88e-01 3.11e-01
Signaling by FLT3 fusion proteins 18 4.41e-03 -3.88e-01 3.59e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 2.62e-02 3.87e-01 1.28e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.81e-04 -3.82e-01 3.45e-03
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.97e-03 3.82e-01 3.31e-02
Synthesis of pyrophosphates in the cytosol 8 6.16e-02 -3.82e-01 2.30e-01
STAT3 nuclear events downstream of ALK signaling 11 2.87e-02 -3.81e-01 1.37e-01
NS1 Mediated Effects on Host Pathways 40 3.08e-05 -3.81e-01 1.01e-03
PDH complex synthesizes acetyl-CoA from PYR 5 1.42e-01 3.79e-01 3.85e-01
Formation of Fibrin Clot (Clotting Cascade) 26 8.20e-04 3.79e-01 1.07e-02
Postmitotic nuclear pore complex (NPC) reformation 27 6.66e-04 -3.78e-01 8.85e-03
Bicarbonate transporters 9 5.00e-02 -3.77e-01 1.98e-01
Defects of platelet adhesion to exposed collagen 7 8.40e-02 3.77e-01 2.83e-01
PI-3K cascade:FGFR3 10 3.90e-02 -3.77e-01 1.67e-01
Digestion 5 1.45e-01 3.77e-01 3.90e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 7.40e-05 3.76e-01 2.05e-03
Pyrimidine salvage 10 3.94e-02 3.76e-01 1.68e-01
Mucopolysaccharidoses 11 3.09e-02 3.76e-01 1.44e-01
Nuclear import of Rev protein 34 1.50e-04 -3.76e-01 3.11e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 3.21e-02 -3.73e-01 1.48e-01
Phosphorylation of Emi1 6 1.14e-01 -3.73e-01 3.39e-01
Defensins 8 6.92e-02 3.71e-01 2.47e-01
Amyloid fiber formation 51 4.61e-06 3.71e-01 2.02e-04
SUMO is proteolytically processed 6 1.16e-01 -3.71e-01 3.42e-01
Interleukin-18 signaling 6 1.17e-01 3.70e-01 3.43e-01
CS/DS degradation 9 5.52e-02 3.69e-01 2.12e-01
Hyaluronan uptake and degradation 12 2.71e-02 3.68e-01 1.31e-01
Recycling of eIF2:GDP 8 7.22e-02 3.67e-01 2.55e-01
HDMs demethylate histones 22 2.89e-03 -3.67e-01 2.55e-02
Transport of the SLBP independent Mature mRNA 35 1.84e-04 -3.65e-01 3.47e-03
Eicosanoids 8 7.41e-02 3.65e-01 2.60e-01
Degradation of DVL 43 3.65e-05 3.64e-01 1.17e-03
Hydrolysis of LPC 8 7.51e-02 3.63e-01 2.63e-01
Interactions of Rev with host cellular proteins 37 1.31e-04 -3.63e-01 2.81e-03
Nuclear Pore Complex (NPC) Disassembly 36 1.65e-04 -3.63e-01 3.32e-03
Peptide chain elongation 87 5.74e-09 3.61e-01 6.91e-07
Ubiquitin-dependent degradation of Cyclin D 39 1.05e-04 3.59e-01 2.50e-03
Signaling by cytosolic FGFR1 fusion mutants 18 8.45e-03 -3.59e-01 5.99e-02
Activation of the AP-1 family of transcription factors 10 5.00e-02 3.58e-01 1.98e-01
FGFR4 ligand binding and activation 5 1.66e-01 -3.58e-01 4.29e-01
Pentose phosphate pathway 13 2.56e-02 3.57e-01 1.26e-01
Rev-mediated nuclear export of HIV RNA 35 2.56e-04 -3.57e-01 4.39e-03
TRAF3-dependent IRF activation pathway 13 2.63e-02 -3.56e-01 1.28e-01
Anchoring fibril formation 8 8.18e-02 3.55e-01 2.79e-01
Synthesis of GDP-mannose 6 1.32e-01 3.55e-01 3.67e-01
Vif-mediated degradation of APOBEC3G 41 8.50e-05 3.55e-01 2.21e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 3.58e-07 3.54e-01 2.29e-05
Digestion and absorption 7 1.05e-01 3.54e-01 3.23e-01
RHO GTPases activate IQGAPs 25 2.20e-03 3.54e-01 2.08e-02
IFNG signaling activates MAPKs 8 8.34e-02 3.53e-01 2.82e-01
RUNX1 regulates expression of components of tight junctions 5 1.71e-01 3.53e-01 4.36e-01
Growth hormone receptor signaling 20 6.28e-03 3.53e-01 4.76e-02
Heme signaling 45 4.21e-05 -3.53e-01 1.31e-03
SARS-CoV-1 modulates host translation machinery 36 2.50e-04 3.53e-01 4.34e-03
Processive synthesis on the C-strand of the telomere 19 7.90e-03 -3.52e-01 5.72e-02
Advanced glycosylation endproduct receptor signaling 12 3.48e-02 3.52e-01 1.56e-01
Synthesis of PIPs at the late endosome membrane 11 4.35e-02 -3.51e-01 1.80e-01
Metabolism of polyamines 46 3.76e-05 3.51e-01 1.19e-03
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.26e-04 3.51e-01 5.19e-03
Germ layer formation at gastrulation 9 6.91e-02 -3.50e-01 2.47e-01
Viral mRNA Translation 87 1.83e-08 3.49e-01 1.43e-06
SUMOylation of ubiquitinylation proteins 39 1.64e-04 -3.49e-01 3.32e-03
Transport of the SLBP Dependant Mature mRNA 36 2.95e-04 -3.49e-01 4.95e-03
Biosynthesis of specialized proresolving mediators (SPMs) 16 1.58e-02 3.49e-01 9.09e-02
Regulation of Apoptosis 40 1.39e-04 3.48e-01 2.91e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.74e-04 3.47e-01 3.35e-03
p53-Independent DNA Damage Response 39 1.74e-04 3.47e-01 3.35e-03
p53-Independent G1/S DNA damage checkpoint 39 1.74e-04 3.47e-01 3.35e-03
Eukaryotic Translation Elongation 92 1.02e-08 3.45e-01 1.03e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 2.93e-09 3.45e-01 4.04e-07
Glutamate and glutamine metabolism 12 3.87e-02 3.45e-01 1.66e-01
Glutathione conjugation 27 2.10e-03 3.42e-01 2.03e-02
Interactions of Vpr with host cellular proteins 37 3.47e-04 -3.40e-01 5.31e-03
Signaling by PDGFR in disease 19 1.04e-02 -3.39e-01 6.67e-02
Detoxification of Reactive Oxygen Species 30 1.34e-03 3.38e-01 1.47e-02
Impaired BRCA2 binding to PALB2 24 4.18e-03 -3.38e-01 3.44e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.85e-04 3.37e-01 3.47e-03
Propionyl-CoA catabolism 5 1.92e-01 -3.37e-01 4.64e-01
mRNA Editing 8 9.89e-02 -3.37e-01 3.09e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 5.22e-03 3.36e-01 4.05e-02
Formation of a pool of free 40S subunits 99 7.50e-09 3.36e-01 8.03e-07
Signaling by FGFR4 in disease 11 5.37e-02 -3.36e-01 2.09e-01
Killing mechanisms 10 6.58e-02 3.36e-01 2.38e-01
WNT5:FZD7-mediated leishmania damping 10 6.58e-02 3.36e-01 2.38e-01
Hedgehog ligand biogenesis 47 6.88e-05 3.36e-01 1.98e-03
Vpu mediated degradation of CD4 39 3.13e-04 3.33e-01 5.03e-03
Arachidonate metabolism 47 7.65e-05 3.33e-01 2.08e-03
Regulation of RUNX3 expression and activity 45 1.10e-04 3.33e-01 2.55e-03
PI-3K cascade:FGFR2 13 3.76e-02 -3.33e-01 1.63e-01
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.08e-09 3.32e-01 3.09e-07
Complex I biogenesis 66 3.18e-06 3.32e-01 1.50e-04
Phenylalanine and tyrosine metabolism 9 8.55e-02 3.31e-01 2.85e-01
Maturation of protein 3a 9683673 9 8.56e-02 -3.31e-01 2.85e-01
Maturation of protein 3a 9694719 9 8.56e-02 -3.31e-01 2.85e-01
Biosynthesis of maresins 6 1.61e-01 -3.31e-01 4.20e-01
Degradation of cysteine and homocysteine 12 4.73e-02 3.31e-01 1.91e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 4.46e-04 3.29e-01 6.47e-03
Hyaluronan metabolism 15 2.79e-02 3.28e-01 1.34e-01
SUMOylation of DNA replication proteins 46 1.23e-04 -3.27e-01 2.75e-03
Glycosphingolipid catabolism 31 1.62e-03 3.27e-01 1.70e-02
RHO GTPases Activate Rhotekin and Rhophilins 8 1.10e-01 3.27e-01 3.31e-01
Cap-dependent Translation Initiation 117 1.08e-09 3.26e-01 1.73e-07
Eukaryotic Translation Initiation 117 1.08e-09 3.26e-01 1.73e-07
Sphingolipid catabolism 11 6.11e-02 3.26e-01 2.30e-01
Urea cycle 7 1.35e-01 3.26e-01 3.74e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 9.08e-02 3.25e-01 2.93e-01
Phospholipase C-mediated cascade; FGFR4 6 1.68e-01 -3.25e-01 4.33e-01
RHO GTPases activate PKNs 46 1.36e-04 3.25e-01 2.89e-03
Transport of nucleotide sugars 9 9.15e-02 3.25e-01 2.94e-01
Passive transport by Aquaporins 6 1.68e-01 3.25e-01 4.33e-01
Eicosanoid ligand-binding receptors 13 4.33e-02 3.24e-01 1.80e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 2.88e-04 3.23e-01 4.86e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 110 4.61e-09 3.23e-01 5.93e-07
Cardiogenesis 14 3.65e-02 -3.23e-01 1.60e-01
Sensing of DNA Double Strand Breaks 6 1.71e-01 -3.22e-01 4.36e-01
RUNX2 regulates osteoblast differentiation 19 1.50e-02 3.22e-01 8.76e-02
Hh mutants are degraded by ERAD 42 3.05e-04 3.22e-01 5.03e-03
Neutrophil degranulation 456 5.92e-32 3.21e-01 1.14e-28
Removal of the Flap Intermediate from the C-strand 17 2.20e-02 -3.21e-01 1.14e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 1.74e-01 -3.21e-01 4.40e-01
Signaling by FGFR3 in disease 14 3.78e-02 -3.21e-01 1.64e-01
E2F-enabled inhibition of pre-replication complex formation 9 9.64e-02 -3.20e-01 3.04e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 1.18e-01 3.19e-01 3.43e-01
Impaired BRCA2 binding to RAD51 35 1.10e-03 -3.19e-01 1.29e-02
The activation of arylsulfatases 10 8.13e-02 3.18e-01 2.79e-01
Telomere C-strand synthesis initiation 13 4.77e-02 -3.17e-01 1.92e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.20e-01 3.17e-01 4.98e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 1.22e-02 3.16e-01 7.37e-02
Neurodegenerative Diseases 21 1.22e-02 3.16e-01 7.37e-02
TRAF6 mediated IRF7 activation 15 3.42e-02 -3.16e-01 1.54e-01
Signalling to RAS 19 1.72e-02 3.16e-01 9.61e-02
Hh mutants abrogate ligand secretion 43 3.42e-04 3.16e-01 5.27e-03
Regulation of PTEN mRNA translation 13 4.92e-02 -3.15e-01 1.97e-01
RAS processing 23 9.15e-03 3.14e-01 6.23e-02
Defective CFTR causes cystic fibrosis 47 2.02e-04 3.13e-01 3.60e-03
p75NTR signals via NF-kB 15 3.61e-02 3.13e-01 1.59e-01
NF-kB is activated and signals survival 12 6.18e-02 3.11e-01 2.31e-01
Negative regulation of NOTCH4 signaling 44 3.52e-04 3.11e-01 5.34e-03
SRP-dependent cotranslational protein targeting to membrane 110 1.71e-08 3.11e-01 1.43e-06
Recycling of bile acids and salts 10 8.97e-02 -3.10e-01 2.92e-01
RHOT1 GTPase cycle 5 2.31e-01 3.09e-01 5.14e-01
Cristae formation 33 2.16e-03 3.09e-01 2.05e-02
Eukaryotic Translation Termination 91 3.69e-07 3.08e-01 2.29e-05
Acyl chain remodeling of CL 5 2.33e-01 3.08e-01 5.17e-01
Signaling by MAPK mutants 6 1.91e-01 3.08e-01 4.64e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.36e-05 3.08e-01 1.33e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.28e-04 3.07e-01 2.80e-03
Aggrephagy 34 1.95e-03 3.07e-01 1.92e-02
Heme degradation 10 9.30e-02 3.07e-01 2.96e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 1.54e-04 3.06e-01 3.16e-03
Selenocysteine synthesis 91 4.44e-07 3.06e-01 2.68e-05
Glycogen breakdown (glycogenolysis) 13 5.61e-02 3.06e-01 2.15e-01
Dermatan sulfate biosynthesis 6 1.95e-01 3.06e-01 4.68e-01
Cell-extracellular matrix interactions 15 4.07e-02 3.05e-01 1.73e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 1.97e-01 3.04e-01 4.71e-01
Formation of axial mesoderm 6 1.99e-01 -3.03e-01 4.73e-01
Platelet Aggregation (Plug Formation) 29 4.78e-03 3.03e-01 3.83e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 59 6.15e-05 3.02e-01 1.82e-03
Josephin domain DUBs 10 9.91e-02 3.01e-01 3.09e-01
Regulation of PTEN stability and activity 55 1.14e-04 3.01e-01 2.61e-03
Translation initiation complex formation 58 7.46e-05 3.01e-01 2.05e-03
Glyoxylate metabolism and glycine degradation 13 6.06e-02 3.01e-01 2.29e-01
Ca2+ activated K+ channels 6 2.03e-01 3.00e-01 4.79e-01
Signal transduction by L1 20 2.02e-02 3.00e-01 1.08e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 5.99e-07 2.99e-01 3.30e-05
rRNA processing in the mitochondrion 24 1.11e-02 2.99e-01 6.93e-02
SUMOylation of DNA damage response and repair proteins 77 5.61e-06 -2.99e-01 2.35e-04
MET receptor recycling 9 1.21e-01 2.99e-01 3.49e-01
Downstream signaling of activated FGFR4 18 2.88e-02 -2.98e-01 1.37e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 2.07e-01 2.97e-01 4.84e-01
Respiratory electron transport 149 3.85e-10 2.97e-01 8.25e-08
Ribosomal scanning and start codon recognition 58 9.28e-05 2.97e-01 2.30e-03
Neurotransmitter clearance 5 2.51e-01 2.96e-01 5.37e-01
Synthesis of UDP-N-acetyl-glucosamine 8 1.47e-01 -2.96e-01 3.94e-01
Defective Intrinsic Pathway for Apoptosis 24 1.20e-02 2.96e-01 7.30e-02
ISG15 antiviral mechanism 72 1.44e-05 -2.96e-01 5.44e-04
Nuclear Envelope Breakdown 53 1.98e-04 -2.95e-01 3.57e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 9.33e-04 2.95e-01 1.15e-02
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 2.53e-01 -2.95e-01 5.39e-01
Cellular response to starvation 147 7.02e-10 2.94e-01 1.35e-07
Signaling by FGFR1 in disease 32 4.11e-03 -2.93e-01 3.40e-02
Loss of Function of SMAD2/3 in Cancer 7 1.81e-01 -2.92e-01 4.51e-01
GABA synthesis, release, reuptake and degradation 11 9.35e-02 -2.92e-01 2.96e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.15e-02 -2.92e-01 7.04e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.15e-02 -2.92e-01 7.04e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.15e-02 -2.92e-01 7.04e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.15e-02 -2.92e-01 7.04e-02
Homologous DNA Pairing and Strand Exchange 43 9.26e-04 -2.92e-01 1.15e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 1.82e-01 2.91e-01 4.51e-01
Metabolic disorders of biological oxidation enzymes 23 1.57e-02 2.91e-01 9.08e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.29e-03 -2.90e-01 1.43e-02
Diseases of DNA Double-Strand Break Repair 41 1.29e-03 -2.90e-01 1.43e-02
Phospholipase C-mediated cascade; FGFR3 5 2.61e-01 -2.90e-01 5.46e-01
Proteasome assembly 51 3.41e-04 2.90e-01 5.27e-03
Platelet Adhesion to exposed collagen 15 5.22e-02 2.89e-01 2.05e-01
Spry regulation of FGF signaling 16 4.50e-02 2.89e-01 1.85e-01
Diseases of carbohydrate metabolism 29 6.99e-03 2.89e-01 5.24e-02
Acetylcholine Neurotransmitter Release Cycle 10 1.14e-01 -2.88e-01 3.40e-01
Phenylalanine metabolism 5 2.64e-01 2.88e-01 5.49e-01
Nuclear events mediated by NFE2L2 82 6.46e-06 2.88e-01 2.65e-04
Processive synthesis on the lagging strand 15 5.38e-02 -2.88e-01 2.09e-01
Diseases of DNA repair 51 3.94e-04 -2.87e-01 5.92e-03
Mitochondrial protein import 63 8.34e-05 2.87e-01 2.21e-03
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.37e-01 2.87e-01 3.77e-01
PINK1-PRKN Mediated Mitophagy 31 5.79e-03 2.86e-01 4.46e-02
Gain-of-function MRAS complexes activate RAF signaling 8 1.61e-01 -2.86e-01 4.20e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.61e-01 -2.86e-01 4.20e-01
Signaling by MRAS-complex mutants 8 1.61e-01 -2.86e-01 4.20e-01
Downstream signaling of activated FGFR3 17 4.13e-02 -2.86e-01 1.74e-01
Complex IV assembly 45 9.12e-04 2.86e-01 1.15e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.44e-02 -2.85e-01 2.37e-01
Prevention of phagosomal-lysosomal fusion 9 1.39e-01 2.85e-01 3.82e-01
Chondroitin sulfate biosynthesis 12 8.77e-02 2.85e-01 2.89e-01
Formation of tubulin folding intermediates by CCT/TriC 21 2.43e-02 2.84e-01 1.21e-01
SARS-CoV-2 modulates host translation machinery 49 5.98e-04 2.83e-01 8.24e-03
Platelet sensitization by LDL 16 5.01e-02 2.83e-01 1.98e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.99e-03 -2.83e-01 1.94e-02
FGFR1 mutant receptor activation 25 1.45e-02 -2.82e-01 8.55e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.78e-03 2.82e-01 6.43e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 9.16e-02 2.81e-01 2.94e-01
Activation of Ca-permeable Kainate Receptor 9 1.46e-01 2.80e-01 3.93e-01
Ionotropic activity of kainate receptors 9 1.46e-01 2.80e-01 3.93e-01
APC/C:Cdc20 mediated degradation of Securin 55 3.35e-04 2.80e-01 5.25e-03
Biosynthesis of DHA-derived SPMs 14 7.05e-02 2.79e-01 2.51e-01
RUNX2 regulates bone development 24 1.85e-02 2.78e-01 1.02e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.89e-03 2.77e-01 1.90e-02
ROS and RNS production in phagocytes 30 8.65e-03 2.77e-01 6.03e-02
N-glycan trimming and elongation in the cis-Golgi 5 2.84e-01 -2.77e-01 5.70e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 4.35e-04 2.77e-01 6.45e-03
Regulation of expression of SLITs and ROBOs 148 6.18e-09 2.77e-01 7.00e-07
RUNX1 regulates estrogen receptor mediated transcription 6 2.41e-01 -2.76e-01 5.26e-01
Interleukin-20 family signaling 17 4.87e-02 -2.76e-01 1.95e-01
Platelet degranulation 105 1.02e-06 2.76e-01 5.47e-05
Regulation of TP53 Activity through Acetylation 29 1.01e-02 -2.76e-01 6.57e-02
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 2.42e-01 2.76e-01 5.28e-01
Stabilization of p53 43 1.78e-03 2.75e-01 1.81e-02
Senescence-Associated Secretory Phenotype (SASP) 65 1.24e-04 2.75e-01 2.75e-03
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.45e-01 -2.74e-01 5.32e-01
HDR through Single Strand Annealing (SSA) 37 4.00e-03 -2.73e-01 3.32e-02
Transport of RCbl within the body 8 1.82e-01 2.73e-01 4.51e-01
FRS-mediated FGFR4 signaling 13 8.91e-02 -2.72e-01 2.92e-01
Fatty acids 8 1.82e-01 2.72e-01 4.51e-01
FGFR2c ligand binding and activation 5 2.93e-01 -2.72e-01 5.78e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.14e-02 2.71e-01 1.12e-01
Downstream signaling of activated FGFR2 20 3.58e-02 -2.71e-01 1.58e-01
PTK6 Regulates Cell Cycle 6 2.53e-01 -2.70e-01 5.39e-01
MECP2 regulates transcription factors 5 2.97e-01 -2.70e-01 5.81e-01
CD209 (DC-SIGN) signaling 20 3.70e-02 -2.69e-01 1.62e-01
Asymmetric localization of PCP proteins 49 1.11e-03 2.69e-01 1.30e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.54e-03 -2.69e-01 2.30e-02
Phosphate bond hydrolysis by NUDT proteins 7 2.18e-01 2.69e-01 4.97e-01
FLT3 signaling by CBL mutants 7 2.19e-01 2.68e-01 4.98e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.60e-02 -2.68e-01 9.17e-02
Degradation of AXIN 42 2.68e-03 2.68e-01 2.39e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 2.20e-01 -2.67e-01 4.98e-01
Degradation of GLI2 by the proteasome 45 1.91e-03 2.67e-01 1.90e-02
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.01e-01 -2.67e-01 5.86e-01
GLI3 is processed to GLI3R by the proteasome 46 1.77e-03 2.66e-01 1.81e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.11e-02 2.66e-01 1.11e-01
IRAK1 recruits IKK complex 14 8.52e-02 2.66e-01 2.85e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 8.52e-02 2.66e-01 2.85e-01
CDC6 association with the ORC:origin complex 8 1.94e-01 -2.65e-01 4.67e-01
Activated point mutants of FGFR2 7 2.26e-01 -2.64e-01 5.07e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 8.68e-02 2.64e-01 2.88e-01
Mitochondrial RNA degradation 25 2.23e-02 2.64e-01 1.15e-01
Mitophagy 38 4.87e-03 2.64e-01 3.88e-02
Antigen processing-Cross presentation 89 1.72e-05 2.64e-01 5.86e-04
SIRT1 negatively regulates rRNA expression 22 3.30e-02 2.63e-01 1.50e-01
ERKs are inactivated 13 1.01e-01 2.62e-01 3.15e-01
GP1b-IX-V activation signalling 11 1.32e-01 2.62e-01 3.67e-01
Removal of the Flap Intermediate 14 8.96e-02 -2.62e-01 2.92e-01
Response to elevated platelet cytosolic Ca2+ 109 2.29e-06 2.62e-01 1.13e-04
PKMTs methylate histone lysines 43 3.00e-03 -2.62e-01 2.63e-02
ERBB2 Activates PTK6 Signaling 8 2.00e-01 2.61e-01 4.76e-01
Glycerophospholipid catabolism 7 2.31e-01 2.61e-01 5.14e-01
Sulfur amino acid metabolism 22 3.38e-02 2.61e-01 1.53e-01
Molecules associated with elastic fibres 26 2.12e-02 2.61e-01 1.11e-01
Xenobiotics 12 1.18e-01 -2.61e-01 3.43e-01
Dectin-2 family 19 4.95e-02 2.60e-01 1.98e-01
Smooth Muscle Contraction 34 8.72e-03 2.60e-01 6.04e-02
NFE2L2 regulates pentose phosphate pathway genes 8 2.03e-01 2.60e-01 4.79e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 7.22e-02 -2.60e-01 2.55e-01
Mismatch Repair 15 8.21e-02 -2.59e-01 2.79e-01
Regulation of RUNX2 expression and activity 54 1.03e-03 2.58e-01 1.23e-02
Cobalamin (Cbl) metabolism 7 2.37e-01 -2.58e-01 5.23e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 3.49e-03 -2.57e-01 2.99e-02
Acyl chain remodelling of PI 10 1.59e-01 2.57e-01 4.19e-01
tRNA processing in the mitochondrion 24 2.94e-02 2.57e-01 1.39e-01
NOTCH2 intracellular domain regulates transcription 11 1.40e-01 -2.57e-01 3.84e-01
Glycogen metabolism 22 3.72e-02 2.57e-01 1.62e-01
VEGF binds to VEGFR leading to receptor dimerization 5 3.21e-01 2.57e-01 6.10e-01
VEGF ligand-receptor interactions 5 3.21e-01 2.57e-01 6.10e-01
Packaging Of Telomere Ends 18 5.97e-02 2.56e-01 2.26e-01
SUMOylation 167 1.21e-08 -2.56e-01 1.11e-06
Selenoamino acid metabolism 114 2.53e-06 2.55e-01 1.22e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.89e-04 -2.54e-01 3.50e-03
NFE2L2 regulating ER-stress associated genes 5 3.25e-01 -2.54e-01 6.15e-01
FRS-mediated FGFR3 signaling 12 1.28e-01 -2.53e-01 3.63e-01
Defective GALNT12 causes CRCS1 9 1.89e-01 2.53e-01 4.64e-01
RA biosynthesis pathway 13 1.15e-01 2.53e-01 3.41e-01
Transport of vitamins, nucleosides, and related molecules 31 1.50e-02 2.52e-01 8.76e-02
Aerobic respiration and respiratory electron transport 245 1.07e-11 2.52e-01 2.96e-09
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 1.91e-01 2.52e-01 4.64e-01
Negative feedback regulation of MAPK pathway 6 2.85e-01 2.52e-01 5.70e-01
Creatine metabolism 6 2.85e-01 -2.52e-01 5.70e-01
RSV-host interactions 78 1.21e-04 -2.52e-01 2.73e-03
Beta-oxidation of pristanoyl-CoA 9 1.91e-01 2.52e-01 4.64e-01
Phospholipase C-mediated cascade; FGFR2 8 2.18e-01 -2.52e-01 4.97e-01
Gluconeogenesis 19 5.77e-02 2.52e-01 2.20e-01
Sema4D in semaphorin signaling 22 4.21e-02 2.50e-01 1.76e-01
mTORC1-mediated signalling 24 3.38e-02 2.50e-01 1.53e-01
Frs2-mediated activation 11 1.51e-01 2.50e-01 4.03e-01
Arachidonate production from DAG 5 3.33e-01 2.50e-01 6.22e-01
SUMOylation of RNA binding proteins 47 3.05e-03 -2.50e-01 2.66e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.06e-01 2.50e-01 3.23e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.06e-01 2.50e-01 3.23e-01
Formation of WDR5-containing histone-modifying complexes 42 5.22e-03 -2.49e-01 4.05e-02
ER-Phagosome pathway 75 1.93e-04 2.49e-01 3.50e-03
Carnitine shuttle 12 1.37e-01 -2.48e-01 3.78e-01
Telomere C-strand (Lagging Strand) Synthesis 34 1.25e-02 -2.48e-01 7.48e-02
Cellular response to hypoxia 59 1.03e-03 2.47e-01 1.23e-02
Abacavir ADME 5 3.39e-01 -2.47e-01 6.28e-01
SUMO E3 ligases SUMOylate target proteins 161 6.94e-08 -2.46e-01 4.77e-06
SUMOylation of chromatin organization proteins 57 1.35e-03 -2.45e-01 1.48e-02
Carboxyterminal post-translational modifications of tubulin 34 1.33e-02 2.45e-01 7.89e-02
Intrinsic Pathway of Fibrin Clot Formation 15 1.01e-01 2.45e-01 3.13e-01
Downregulation of ERBB4 signaling 8 2.30e-01 2.45e-01 5.14e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 1.60e-01 2.45e-01 4.19e-01
Insulin receptor recycling 24 3.80e-02 2.45e-01 1.64e-01
Transcriptional regulation of granulopoiesis 44 5.01e-03 2.44e-01 3.98e-02
Cytosolic sulfonation of small molecules 18 7.32e-02 2.44e-01 2.58e-01
Keratinization 38 9.42e-03 2.43e-01 6.30e-02
Evasion by RSV of host interferon responses 20 6.10e-02 -2.42e-01 2.30e-01
Early Phase of HIV Life Cycle 14 1.18e-01 -2.41e-01 3.43e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 3.51e-01 -2.41e-01 6.40e-01
Regulation of RAS by GAPs 55 2.01e-03 2.41e-01 1.96e-02
Degradation of GLI1 by the proteasome 46 4.78e-03 2.40e-01 3.83e-02
p130Cas linkage to MAPK signaling for integrins 11 1.68e-01 2.40e-01 4.32e-01
FRS-mediated FGFR2 signaling 15 1.07e-01 -2.40e-01 3.26e-01
NRIF signals cell death from the nucleus 15 1.09e-01 2.39e-01 3.29e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 3.84e-02 -2.39e-01 1.65e-01
Signaling by TGFBR3 39 9.75e-03 -2.39e-01 6.43e-02
Formation of the ureteric bud 5 3.58e-01 2.38e-01 6.45e-01
Cleavage of the damaged purine 22 5.38e-02 2.37e-01 2.09e-01
Depurination 22 5.38e-02 2.37e-01 2.09e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 5.38e-02 2.37e-01 2.09e-01
Integrin signaling 22 5.43e-02 2.37e-01 2.10e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 3.17e-01 2.36e-01 6.06e-01
Regulation of localization of FOXO transcription factors 12 1.57e-01 2.36e-01 4.14e-01
RSK activation 7 2.80e-01 2.36e-01 5.68e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.76e-01 2.35e-01 4.42e-01
Circadian Clock 67 8.68e-04 -2.35e-01 1.11e-02
Constitutive Signaling by EGFRvIII 14 1.28e-01 -2.35e-01 3.62e-01
Signaling by EGFRvIII in Cancer 14 1.28e-01 -2.35e-01 3.62e-01
Complex III assembly 23 5.12e-02 2.35e-01 2.02e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 1.52e-03 2.35e-01 1.63e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 2.51e-01 -2.34e-01 5.37e-01
Signaling by PDGFRA extracellular domain mutants 12 1.60e-01 -2.34e-01 4.19e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.60e-01 -2.34e-01 4.19e-01
NIK–>noncanonical NF-kB signaling 46 6.05e-03 2.34e-01 4.60e-02
SCF(Skp2)-mediated degradation of p27/p21 50 4.24e-03 2.34e-01 3.46e-02
SHC-related events triggered by IGF1R 7 2.85e-01 -2.33e-01 5.70e-01
Inwardly rectifying K+ channels 23 5.32e-02 2.33e-01 2.08e-01
TGFBR3 regulates TGF-beta signaling 8 2.54e-01 -2.33e-01 5.41e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 1.82e-01 2.32e-01 4.51e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 2.04e-01 2.32e-01 4.79e-01
ABC-family proteins mediated transport 81 3.13e-04 2.32e-01 5.03e-03
TNFs bind their physiological receptors 25 4.54e-02 2.31e-01 1.86e-01
Signaling by ROBO receptors 188 4.61e-08 2.31e-01 3.29e-06
Branched-chain ketoacid dehydrogenase kinase deficiency 5 3.71e-01 2.31e-01 6.58e-01
Signalling to ERKs 32 2.40e-02 2.31e-01 1.21e-01
Elastic fibre formation 33 2.20e-02 2.30e-01 1.14e-01
Activation of the pre-replicative complex 32 2.44e-02 -2.30e-01 1.21e-01
Miro GTPase Cycle 8 2.60e-01 2.30e-01 5.46e-01
CREB phosphorylation 7 2.93e-01 -2.30e-01 5.78e-01
Formation of the cornified envelope 37 1.58e-02 2.29e-01 9.09e-02
Inactivation of CDC42 and RAC1 7 2.94e-01 2.29e-01 5.79e-01
Regulation of TP53 Activity through Association with Co-factors 13 1.53e-01 -2.29e-01 4.07e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.68e-03 2.29e-01 1.75e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 2.23e-03 2.28e-01 2.10e-02
Beta-oxidation of very long chain fatty acids 11 1.90e-01 2.28e-01 4.64e-01
PCP/CE pathway 75 6.57e-04 2.28e-01 8.79e-03
SHC-mediated cascade:FGFR4 11 1.92e-01 -2.27e-01 4.64e-01
Defective C1GALT1C1 causes TNPS 10 2.14e-01 2.27e-01 4.93e-01
Activation of ATR in response to replication stress 37 1.71e-02 -2.27e-01 9.61e-02
CDK-mediated phosphorylation and removal of Cdc6 60 2.41e-03 2.26e-01 2.20e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 2.26e-03 2.26e-01 2.10e-02
PI3K/AKT activation 8 2.69e-01 2.26e-01 5.54e-01
Thyroxine biosynthesis 5 3.83e-01 2.25e-01 6.66e-01
Regulation of signaling by NODAL 6 3.39e-01 2.25e-01 6.28e-01
Citric acid cycle (TCA cycle) 34 2.33e-02 2.25e-01 1.18e-01
Cell recruitment (pro-inflammatory response) 25 5.18e-02 2.25e-01 2.04e-01
Purinergic signaling in leishmaniasis infection 25 5.18e-02 2.25e-01 2.04e-01
Regulation of IFNA/IFNB signaling 12 1.81e-01 -2.23e-01 4.51e-01
Glycosphingolipid metabolism 46 9.02e-03 2.23e-01 6.16e-02
RHOBTB2 GTPase cycle 23 6.48e-02 -2.22e-01 2.37e-01
Glycogen synthesis 11 2.02e-01 2.22e-01 4.78e-01
Transcriptional regulation by RUNX2 89 3.05e-04 2.21e-01 5.03e-03
Signaling by Leptin 10 2.26e-01 2.21e-01 5.07e-01
Role of second messengers in netrin-1 signaling 6 3.48e-01 2.21e-01 6.36e-01
ABC transporter disorders 60 3.11e-03 2.21e-01 2.69e-02
Lagging Strand Synthesis 20 8.81e-02 -2.20e-01 2.90e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.54e-01 -2.20e-01 4.08e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 2.34e-03 2.20e-01 2.16e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 3.14e-01 -2.20e-01 6.04e-01
Activated NTRK2 signals through FRS2 and FRS3 8 2.84e-01 -2.19e-01 5.70e-01
Signaling by ALK 24 6.36e-02 -2.19e-01 2.35e-01
Processing and activation of SUMO 10 2.31e-01 -2.19e-01 5.14e-01
Respiratory Syncytial Virus Infection Pathway 99 1.70e-04 -2.19e-01 3.35e-03
Signaling by NODAL 15 1.44e-01 2.18e-01 3.89e-01
Inflammasomes 21 8.50e-02 2.17e-01 2.85e-01
Metabolism of amino acids and derivatives 305 7.80e-11 2.16e-01 1.88e-08
Somitogenesis 41 1.65e-02 2.16e-01 9.33e-02
Negative regulation of FGFR1 signaling 25 6.12e-02 2.16e-01 2.30e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 1.95e-02 2.16e-01 1.05e-01
Viral Messenger RNA Synthesis 44 1.31e-02 -2.16e-01 7.86e-02
ERBB2 Regulates Cell Motility 10 2.38e-01 2.16e-01 5.23e-01
TYSND1 cleaves peroxisomal proteins 7 3.23e-01 2.16e-01 6.14e-01
Regulation of PTEN localization 9 2.63e-01 2.15e-01 5.48e-01
MAP2K and MAPK activation 36 2.56e-02 2.15e-01 1.26e-01
Purine catabolism 16 1.37e-01 2.14e-01 3.79e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.64e-01 2.14e-01 6.49e-01
Ephrin signaling 18 1.16e-01 2.14e-01 3.42e-01
KEAP1-NFE2L2 pathway 107 1.30e-04 2.14e-01 2.81e-03
Signaling by NOTCH4 68 2.27e-03 2.14e-01 2.10e-02
p38MAPK events 13 1.82e-01 2.14e-01 4.51e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 4.08e-01 2.14e-01 6.78e-01
Activation of RAC1 11 2.20e-01 2.14e-01 4.98e-01
Cellular response to mitochondrial stress 9 2.67e-01 2.14e-01 5.51e-01
Pyrimidine catabolism 9 2.67e-01 2.14e-01 5.51e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 4.08e-01 -2.14e-01 6.78e-01
FLT3 signaling through SRC family kinases 6 3.65e-01 2.14e-01 6.51e-01
NPAS4 regulates expression of target genes 16 1.39e-01 2.13e-01 3.83e-01
G1/S DNA Damage Checkpoints 54 6.72e-03 2.13e-01 5.06e-02
Polo-like kinase mediated events 16 1.40e-01 -2.13e-01 3.84e-01
p53-Dependent G1 DNA Damage Response 52 8.10e-03 2.12e-01 5.81e-02
p53-Dependent G1/S DNA damage checkpoint 52 8.10e-03 2.12e-01 5.81e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 2.70e-01 2.12e-01 5.55e-01
Antiviral mechanism by IFN-stimulated genes 140 1.54e-05 -2.12e-01 5.58e-04
Diseases associated with N-glycosylation of proteins 20 1.03e-01 2.11e-01 3.18e-01
Interferon Signaling 240 1.85e-08 -2.11e-01 1.43e-06
Regulation of gene expression in beta cells 8 3.03e-01 -2.10e-01 5.87e-01
Regulation of HSF1-mediated heat shock response 79 1.24e-03 -2.10e-01 1.41e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 4.16e-01 -2.10e-01 6.85e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 4.16e-01 -2.10e-01 6.85e-01
Regulation of BACH1 activity 11 2.28e-01 2.10e-01 5.11e-01
Laminin interactions 26 6.40e-02 2.10e-01 2.36e-01
Prolonged ERK activation events 13 1.90e-01 2.10e-01 4.64e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 2.77e-01 2.09e-01 5.65e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.52e-01 2.09e-01 5.37e-01
BBSome-mediated cargo-targeting to cilium 23 8.26e-02 -2.09e-01 2.81e-01
TNFR1-mediated ceramide production 6 3.76e-01 -2.09e-01 6.61e-01
Inhibition of DNA recombination at telomere 33 3.82e-02 2.08e-01 1.65e-01
Metabolism of non-coding RNA 53 8.67e-03 -2.08e-01 6.03e-02
snRNP Assembly 53 8.67e-03 -2.08e-01 6.03e-02
Translocation of ZAP-70 to Immunological synapse 24 7.73e-02 -2.08e-01 2.68e-01
Selective autophagy 77 1.59e-03 2.08e-01 1.68e-02
Physiological factors 9 2.83e-01 2.07e-01 5.70e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.16e-01 -2.06e-01 4.95e-01
Interleukin-35 Signalling 12 2.16e-01 -2.06e-01 4.95e-01
Glycogen storage diseases 13 1.98e-01 2.06e-01 4.72e-01
FGFR2 alternative splicing 25 7.47e-02 2.06e-01 2.62e-01
Transport of Mature Transcript to Cytoplasm 81 1.40e-03 -2.05e-01 1.52e-02
Mitochondrial protein degradation 96 5.14e-04 2.05e-01 7.34e-03
Deadenylation of mRNA 22 9.63e-02 -2.05e-01 3.04e-01
Condensation of Prometaphase Chromosomes 11 2.40e-01 -2.05e-01 5.25e-01
Downregulation of ERBB2:ERBB3 signaling 12 2.20e-01 2.05e-01 4.98e-01
Transcriptional activation of mitochondrial biogenesis 52 1.09e-02 -2.04e-01 6.87e-02
Infection with Mycobacterium tuberculosis 26 7.20e-02 2.04e-01 2.55e-01
Molybdenum cofactor biosynthesis 6 3.88e-01 -2.03e-01 6.67e-01
RUNX2 regulates genes involved in cell migration 6 3.88e-01 2.03e-01 6.67e-01
Interconversion of nucleotide di- and triphosphates 27 6.78e-02 2.03e-01 2.43e-01
Interleukin-6 signaling 11 2.44e-01 -2.03e-01 5.31e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 7.93e-02 -2.03e-01 2.75e-01
Assembly of the ORC complex at the origin of replication 23 9.29e-02 2.02e-01 2.96e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 1.55e-02 2.02e-01 8.99e-02
Signaling by RNF43 mutants 7 3.56e-01 -2.02e-01 6.45e-01
GDP-fucose biosynthesis 6 3.94e-01 2.01e-01 6.69e-01
Gap junction assembly 17 1.52e-01 2.01e-01 4.05e-01
Acyl chain remodelling of PE 20 1.21e-01 2.01e-01 3.49e-01
Signaling by high-kinase activity BRAF mutants 33 4.65e-02 2.00e-01 1.88e-01
SHC-mediated cascade:FGFR3 10 2.73e-01 -2.00e-01 5.58e-01
Pre-NOTCH Processing in Golgi 18 1.41e-01 -2.00e-01 3.85e-01
Cellular response to chemical stress 179 3.83e-06 2.00e-01 1.76e-04
PD-1 signaling 28 6.72e-02 -2.00e-01 2.41e-01
RNA Polymerase I Promoter Escape 45 2.04e-02 2.00e-01 1.08e-01
Sphingolipid metabolism 92 9.36e-04 2.00e-01 1.15e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.23e-01 -1.99e-01 3.52e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.40e-01 -1.99e-01 7.05e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 3.87e-02 1.99e-01 1.66e-01
Cellular response to heat stress 94 8.53e-04 -1.99e-01 1.10e-02
Neurotoxicity of clostridium toxins 8 3.31e-01 -1.98e-01 6.20e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.72e-01 1.97e-01 4.36e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 5 4.45e-01 1.97e-01 7.07e-01
Methionine salvage pathway 6 4.03e-01 1.97e-01 6.74e-01
Defects in cobalamin (B12) metabolism 13 2.18e-01 -1.97e-01 4.97e-01
SHC-mediated cascade:FGFR2 13 2.18e-01 -1.97e-01 4.97e-01
TNFR2 non-canonical NF-kB pathway 84 1.83e-03 1.97e-01 1.86e-02
Metabolism of folate and pterines 16 1.73e-01 1.97e-01 4.39e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 2.39e-01 1.96e-01 5.24e-01
activated TAK1 mediates p38 MAPK activation 23 1.03e-01 1.96e-01 3.19e-01
APOBEC3G mediated resistance to HIV-1 infection 5 4.49e-01 -1.96e-01 7.13e-01
Sema4D mediated inhibition of cell attachment and migration 7 3.71e-01 1.95e-01 6.58e-01
Sema4D induced cell migration and growth-cone collapse 19 1.41e-01 1.95e-01 3.84e-01
Attenuation phase 23 1.06e-01 -1.95e-01 3.24e-01
HSF1-dependent transactivation 30 6.57e-02 -1.94e-01 2.38e-01
Coenzyme A biosynthesis 7 3.74e-01 -1.94e-01 6.60e-01
Activation of NF-kappaB in B cells 54 1.37e-02 1.94e-01 8.11e-02
Translation 292 1.17e-08 1.94e-01 1.11e-06
Mitochondrial translation elongation 90 1.49e-03 1.94e-01 1.61e-02
SARS-CoV-2 modulates autophagy 11 2.66e-01 -1.94e-01 5.51e-01
Metabolism of porphyrins 22 1.17e-01 1.93e-01 3.43e-01
PI5P Regulates TP53 Acetylation 8 3.45e-01 -1.93e-01 6.35e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 5.42e-04 -1.93e-01 7.57e-03
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 3.78e-01 1.93e-01 6.61e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.10e-01 1.92e-01 3.31e-01
Depolymerization of the Nuclear Lamina 15 1.97e-01 -1.92e-01 4.71e-01
Activation of C3 and C5 7 3.78e-01 1.92e-01 6.61e-01
tRNA processing in the nucleus 59 1.07e-02 -1.92e-01 6.77e-02
Small interfering RNA (siRNA) biogenesis 9 3.18e-01 -1.92e-01 6.08e-01
RHOT2 GTPase cycle 7 3.80e-01 1.92e-01 6.63e-01
CRMPs in Sema3A signaling 14 2.16e-01 1.91e-01 4.95e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 4.47e-04 1.91e-01 6.47e-03
Nonsense-Mediated Decay (NMD) 113 4.47e-04 1.91e-01 6.47e-03
Assembly of the pre-replicative complex 87 2.12e-03 1.91e-01 2.05e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 34 5.45e-02 -1.91e-01 2.11e-01
Formation of annular gap junctions 10 2.99e-01 1.90e-01 5.83e-01
Basigin interactions 21 1.32e-01 1.90e-01 3.67e-01
Phosphorylation of CD3 and TCR zeta chains 27 8.86e-02 -1.89e-01 2.91e-01
Regulation of RUNX1 Expression and Activity 18 1.64e-01 -1.89e-01 4.26e-01
Netrin mediated repulsion signals 5 4.67e-01 1.88e-01 7.20e-01
Amino acids regulate mTORC1 48 2.44e-02 1.88e-01 1.21e-01
Metabolism of cofactors 25 1.04e-01 1.88e-01 3.22e-01
Extension of Telomeres 51 2.06e-02 -1.87e-01 1.09e-01
Myoclonic epilepsy of Lafora 8 3.59e-01 1.87e-01 6.45e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.20e-01 1.87e-01 3.49e-01
IkBA variant leads to EDA-ID 7 3.92e-01 -1.87e-01 6.69e-01
SOS-mediated signalling 7 3.98e-01 1.84e-01 6.72e-01
Protein localization 157 6.81e-05 1.84e-01 1.98e-03
UCH proteinases 73 6.52e-03 1.84e-01 4.93e-02
Activation of BH3-only proteins 30 8.09e-02 1.84e-01 2.79e-01
Semaphorin interactions 57 1.64e-02 1.84e-01 9.28e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 3.14e-01 -1.84e-01 6.04e-01
Ubiquinol biosynthesis 13 2.51e-01 1.84e-01 5.37e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 3.68e-01 -1.84e-01 6.54e-01
Chaperone Mediated Autophagy 20 1.56e-01 1.83e-01 4.13e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.93e-01 1.83e-01 5.78e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 8.29e-02 -1.83e-01 2.81e-01
Nephron development 5 4.79e-01 -1.83e-01 7.29e-01
Gap junction trafficking and regulation 30 8.35e-02 1.83e-01 2.82e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 4.04e-01 1.82e-01 6.75e-01
Interleukin-1 signaling 99 1.74e-03 1.82e-01 1.80e-02
Incretin synthesis, secretion, and inactivation 14 2.39e-01 1.82e-01 5.24e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 2.39e-01 1.82e-01 5.24e-01
ECM proteoglycans 47 3.14e-02 1.81e-01 1.45e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 4.42e-01 -1.81e-01 7.06e-01
TGFBR1 KD Mutants in Cancer 6 4.42e-01 -1.81e-01 7.06e-01
Uptake and function of diphtheria toxin 6 4.43e-01 1.81e-01 7.06e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 2.41e-02 1.81e-01 1.21e-01
Recycling pathway of L1 40 4.79e-02 1.81e-01 1.93e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 1.18e-01 -1.81e-01 3.43e-01
Degradation of beta-catenin by the destruction complex 72 8.32e-03 1.80e-01 5.93e-02
Platelet activation, signaling and aggregation 221 4.31e-06 1.79e-01 1.93e-04
Surfactant metabolism 20 1.67e-01 1.79e-01 4.30e-01
Integration of provirus 9 3.54e-01 -1.79e-01 6.43e-01
Condensation of Prophase Chromosomes 27 1.08e-01 1.79e-01 3.28e-01
FLT3 signaling in disease 27 1.09e-01 -1.78e-01 3.29e-01
Activation of AMPK downstream of NMDARs 20 1.69e-01 1.78e-01 4.34e-01
Cyclin E associated events during G1/S transition 73 8.77e-03 1.77e-01 6.06e-02
Deactivation of the beta-catenin transactivating complex 36 6.56e-02 -1.77e-01 2.38e-01
Signaling by ERBB2 ECD mutants 15 2.35e-01 -1.77e-01 5.19e-01
G0 and Early G1 27 1.14e-01 -1.76e-01 3.39e-01
Organic cation transport 8 3.90e-01 1.75e-01 6.67e-01
Organic cation/anion/zwitterion transport 8 3.90e-01 1.75e-01 6.67e-01
Metabolism of steroid hormones 21 1.64e-01 1.75e-01 4.26e-01
TP53 Regulates Metabolic Genes 78 7.42e-03 1.75e-01 5.42e-02
Signaling by KIT in disease 20 1.75e-01 -1.75e-01 4.41e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 1.75e-01 -1.75e-01 4.41e-01
Interleukin-1 family signaling 127 6.57e-04 1.75e-01 8.79e-03
Sodium/Calcium exchangers 9 3.63e-01 1.75e-01 6.49e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 1.76e-01 1.75e-01 4.42e-01
Azathioprine ADME 20 1.76e-01 1.75e-01 4.42e-01
Cholesterol biosynthesis 26 1.24e-01 1.74e-01 3.54e-01
Norepinephrine Neurotransmitter Release Cycle 12 2.96e-01 -1.74e-01 5.81e-01
AURKA Activation by TPX2 72 1.05e-02 -1.74e-01 6.73e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 3.40e-01 1.74e-01 6.29e-01
MyD88 deficiency (TLR2/4) 14 2.59e-01 1.74e-01 5.45e-01
Maturation of nucleoprotein 9683610 11 3.17e-01 -1.74e-01 6.07e-01
Serotonin Neurotransmitter Release Cycle 13 2.78e-01 -1.74e-01 5.67e-01
Gap junction trafficking 28 1.12e-01 1.74e-01 3.35e-01
Regulation of lipid metabolism by PPARalpha 107 1.93e-03 -1.73e-01 1.91e-02
Signaling by Erythropoietin 24 1.42e-01 -1.73e-01 3.85e-01
Mitochondrial translation initiation 90 4.60e-03 1.73e-01 3.71e-02
Transcriptional regulation by RUNX3 80 7.55e-03 1.73e-01 5.49e-02
Resolution of D-Loop Structures 35 7.72e-02 -1.73e-01 2.68e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 3.99e-01 -1.72e-01 6.74e-01
Transferrin endocytosis and recycling 26 1.29e-01 1.72e-01 3.64e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 1.84e-01 -1.72e-01 4.53e-01
Trafficking of AMPA receptors 20 1.84e-01 -1.72e-01 4.53e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 9.64e-03 1.72e-01 6.43e-02
Transcriptional Regulation by MECP2 49 3.81e-02 -1.71e-01 1.65e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.25e-01 1.71e-01 6.15e-01
TRAIL signaling 8 4.03e-01 -1.71e-01 6.74e-01
Interferon gamma signaling 90 5.10e-03 -1.71e-01 4.01e-02
Interleukin-2 signaling 11 3.27e-01 -1.71e-01 6.16e-01
TRIF-mediated programmed cell death 9 3.77e-01 -1.70e-01 6.61e-01
Mitochondrial translation termination 90 5.29e-03 1.70e-01 4.10e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.15e-02 1.70e-01 1.74e-01
Oncogene Induced Senescence 33 9.11e-02 1.70e-01 2.94e-01
Cyclin A:Cdk2-associated events at S phase entry 75 1.11e-02 1.69e-01 6.93e-02
Interaction between L1 and Ankyrins 27 1.28e-01 -1.69e-01 3.63e-01
Mitochondrial translation 96 4.19e-03 1.69e-01 3.44e-02
PKA activation 15 2.58e-01 1.69e-01 5.44e-01
Iron uptake and transport 52 3.56e-02 1.68e-01 1.58e-01
CLEC7A (Dectin-1) induces NFAT activation 11 3.35e-01 -1.68e-01 6.24e-01
PPARA activates gene expression 105 2.99e-03 -1.68e-01 2.63e-02
Chemokine receptors bind chemokines 41 6.41e-02 1.67e-01 2.36e-01
Formation of apoptosome 11 3.37e-01 1.67e-01 6.26e-01
Regulation of the apoptosome activity 11 3.37e-01 1.67e-01 6.26e-01
SLC transporter disorders 76 1.18e-02 -1.67e-01 7.20e-02
FGFRL1 modulation of FGFR1 signaling 7 4.45e-01 1.67e-01 7.07e-01
Ca2+ pathway 58 2.85e-02 -1.66e-01 1.36e-01
RHOQ GTPase cycle 54 3.49e-02 1.66e-01 1.56e-01
DNA replication initiation 8 4.17e-01 -1.66e-01 6.85e-01
Lysosome Vesicle Biogenesis 32 1.06e-01 1.65e-01 3.23e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 3.67e-01 -1.65e-01 6.52e-01
2-LTR circle formation 7 4.51e-01 -1.65e-01 7.14e-01
MAPK6/MAPK4 signaling 69 1.86e-02 1.64e-01 1.02e-01
Interleukin-15 signaling 14 2.89e-01 -1.64e-01 5.73e-01
Fatty acid metabolism 157 4.01e-04 1.64e-01 6.00e-03
Orc1 removal from chromatin 58 3.12e-02 1.64e-01 1.45e-01
Ribavirin ADME 11 3.48e-01 1.63e-01 6.36e-01
Phase II - Conjugation of compounds 70 1.84e-02 1.63e-01 1.01e-01
Activation of G protein gated Potassium channels 19 2.21e-01 1.62e-01 4.98e-01
G protein gated Potassium channels 19 2.21e-01 1.62e-01 4.98e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 2.21e-01 1.62e-01 4.98e-01
Malate-aspartate shuttle 8 4.28e-01 1.62e-01 6.92e-01
PKA activation in glucagon signalling 14 2.96e-01 1.61e-01 5.81e-01
Netrin-1 signaling 35 9.87e-02 1.61e-01 3.09e-01
Attachment and Entry 9694614 15 2.80e-01 -1.61e-01 5.68e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.82e-01 1.61e-01 4.51e-01
Mitochondrial calcium ion transport 22 1.92e-01 1.61e-01 4.64e-01
Synthesis of Ketone Bodies 6 4.96e-01 1.61e-01 7.38e-01
Activation of SMO 14 2.99e-01 -1.60e-01 5.84e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 4.98e-01 1.60e-01 7.40e-01
Ethanol oxidation 7 4.65e-01 1.60e-01 7.19e-01
Peroxisomal protein import 58 3.59e-02 1.59e-01 1.58e-01
Repression of WNT target genes 14 3.02e-01 -1.59e-01 5.87e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 1.87e-01 1.59e-01 4.59e-01
Elevation of cytosolic Ca2+ levels 13 3.21e-01 1.59e-01 6.11e-01
Regulation of TP53 Activity through Phosphorylation 88 9.96e-03 -1.59e-01 6.52e-02
DNA Damage Reversal 8 4.37e-01 -1.59e-01 7.02e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 76 1.72e-02 1.58e-01 9.61e-02
Formation of paraxial mesoderm 52 4.97e-02 1.57e-01 1.98e-01
IL-6-type cytokine receptor ligand interactions 13 3.26e-01 1.57e-01 6.16e-01
Innate Immune System 970 1.14e-16 1.57e-01 7.33e-14
mRNA decay by 5’ to 3’ exoribonuclease 15 2.93e-01 -1.57e-01 5.78e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 9.71e-03 -1.57e-01 6.43e-02
Amplification of signal from the kinetochores 91 9.71e-03 -1.57e-01 6.43e-02
Loss of Nlp from mitotic centrosomes 69 2.44e-02 -1.57e-01 1.21e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 2.44e-02 -1.57e-01 1.21e-01
Signaling by RAF1 mutants 37 9.91e-02 1.57e-01 3.09e-01
Non-integrin membrane-ECM interactions 49 5.79e-02 1.57e-01 2.20e-01
Negative regulation of MET activity 18 2.50e-01 1.57e-01 5.37e-01
COPI-independent Golgi-to-ER retrograde traffic 45 6.93e-02 1.57e-01 2.47e-01
Resolution of Abasic Sites (AP sites) 38 9.54e-02 -1.56e-01 3.02e-01
Regulation of beta-cell development 22 2.04e-01 -1.56e-01 4.80e-01
DCC mediated attractive signaling 13 3.29e-01 1.56e-01 6.19e-01
Formation of the Early Elongation Complex 33 1.21e-01 1.56e-01 3.49e-01
Formation of the HIV-1 Early Elongation Complex 33 1.21e-01 1.56e-01 3.49e-01
Blood group systems biosynthesis 17 2.66e-01 1.56e-01 5.51e-01
Chromatin modifying enzymes 214 9.38e-05 -1.55e-01 2.30e-03
Chromatin organization 214 9.38e-05 -1.55e-01 2.30e-03
Cation-coupled Chloride cotransporters 6 5.11e-01 -1.55e-01 7.54e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 3.64e-02 -1.55e-01 1.60e-01
MET activates RAP1 and RAC1 10 3.97e-01 1.55e-01 6.72e-01
Glutathione synthesis and recycling 10 3.97e-01 1.55e-01 6.72e-01
Alpha-oxidation of phytanate 6 5.12e-01 1.54e-01 7.55e-01
Processing of Capped Intron-Containing Pre-mRNA 279 8.99e-06 -1.54e-01 3.61e-04
DAP12 signaling 28 1.57e-01 -1.54e-01 4.15e-01
NGF-stimulated transcription 32 1.32e-01 1.54e-01 3.67e-01
Noncanonical activation of NOTCH3 8 4.52e-01 1.54e-01 7.14e-01
SUMOylation of immune response proteins 12 3.57e-01 -1.53e-01 6.45e-01
Regulation of APC/C activators between G1/S and early anaphase 68 2.89e-02 1.53e-01 1.37e-01
LGI-ADAM interactions 9 4.26e-01 -1.53e-01 6.92e-01
Base-Excision Repair, AP Site Formation 29 1.54e-01 1.53e-01 4.08e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 9.01e-02 1.53e-01 2.92e-01
Signaling by RAS mutants 41 9.01e-02 1.53e-01 2.92e-01
Signaling by moderate kinase activity BRAF mutants 41 9.01e-02 1.53e-01 2.92e-01
Signaling downstream of RAS mutants 41 9.01e-02 1.53e-01 2.92e-01
STAT5 Activation 7 4.84e-01 -1.53e-01 7.33e-01
G alpha (z) signalling events 36 1.13e-01 1.53e-01 3.38e-01
Defective GALNT3 causes HFTC 9 4.28e-01 1.53e-01 6.92e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 1.70e-01 1.52e-01 4.35e-01
PCNA-Dependent Long Patch Base Excision Repair 21 2.29e-01 -1.52e-01 5.12e-01
Alpha-protein kinase 1 signaling pathway 11 3.84e-01 1.52e-01 6.66e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 3.64e-01 -1.51e-01 6.49e-01
Interleukin-23 signaling 7 4.88e-01 -1.51e-01 7.34e-01
RAF/MAP kinase cascade 225 9.41e-05 1.51e-01 2.30e-03
Negative regulation of MAPK pathway 42 9.03e-02 1.51e-01 2.92e-01
Anchoring of the basal body to the plasma membrane 97 1.01e-02 -1.51e-01 6.57e-02
Cytochrome c-mediated apoptotic response 13 3.47e-01 1.51e-01 6.36e-01
Regulated proteolysis of p75NTR 11 3.87e-01 1.51e-01 6.67e-01
Peptide ligand-binding receptors 102 8.66e-03 1.50e-01 6.03e-02
Signaling by FGFR in disease 52 6.06e-02 -1.50e-01 2.29e-01
Synthesis of PIPs at the ER membrane 5 5.61e-01 -1.50e-01 7.82e-01
Aryl hydrocarbon receptor signalling 6 5.24e-01 -1.50e-01 7.61e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 5.26e-01 -1.50e-01 7.61e-01
cGMP effects 12 3.75e-01 -1.48e-01 6.60e-01
Adenylate cyclase activating pathway 8 4.70e-01 1.48e-01 7.20e-01
Heme biosynthesis 13 3.57e-01 1.47e-01 6.45e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.11e-01 1.47e-01 4.90e-01
Polymerase switching on the C-strand of the telomere 26 1.95e-01 -1.47e-01 4.68e-01
IRAK2 mediated activation of TAK1 complex 10 4.21e-01 1.47e-01 6.86e-01
Synthesis, secretion, and deacylation of Ghrelin 11 4.00e-01 1.46e-01 6.74e-01
Reversal of alkylation damage by DNA dioxygenases 7 5.03e-01 -1.46e-01 7.45e-01
MET promotes cell motility 34 1.41e-01 1.46e-01 3.84e-01
Nicotinamide salvaging 16 3.12e-01 -1.46e-01 6.02e-01
Nuclear Events (kinase and transcription factor activation) 54 6.37e-02 1.46e-01 2.35e-01
CLEC7A (Dectin-1) signaling 86 1.95e-02 1.46e-01 1.05e-01
Regulation of TP53 Activity 153 1.88e-03 -1.46e-01 1.90e-02
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 5.38e-01 1.45e-01 7.70e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 5.38e-01 1.45e-01 7.70e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 1.22e-01 -1.45e-01 3.52e-01
Telomere Extension By Telomerase 23 2.29e-01 -1.45e-01 5.13e-01
Retrograde neurotrophin signalling 12 3.86e-01 1.45e-01 6.66e-01
Influenza Viral RNA Transcription and Replication 134 3.89e-03 1.44e-01 3.28e-02
Axon guidance 459 1.23e-07 1.44e-01 8.18e-06
Formation of the Editosome 6 5.42e-01 -1.44e-01 7.70e-01
mRNA Editing: C to U Conversion 6 5.42e-01 -1.44e-01 7.70e-01
Transcriptional regulation of white adipocyte differentiation 77 2.94e-02 -1.44e-01 1.39e-01
rRNA processing 213 3.09e-04 1.43e-01 5.03e-03
Regulation of MITF-M-dependent genes involved in pigmentation 38 1.27e-01 -1.43e-01 3.62e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 4.34e-01 -1.43e-01 6.98e-01
VEGFA-VEGFR2 Pathway 92 1.79e-02 1.43e-01 9.91e-02
Regulation of PLK1 Activity at G2/M Transition 87 2.14e-02 -1.43e-01 1.12e-01
Post-translational protein phosphorylation 67 4.35e-02 1.43e-01 1.80e-01
Insulin processing 19 2.83e-01 -1.42e-01 5.70e-01
APC/C-mediated degradation of cell cycle proteins 75 3.30e-02 1.42e-01 1.50e-01
Regulation of mitotic cell cycle 75 3.30e-02 1.42e-01 1.50e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 2.96e-01 -1.42e-01 5.81e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 4.55e-02 -1.42e-01 1.86e-01
Cargo recognition for clathrin-mediated endocytosis 87 2.18e-02 1.42e-01 1.14e-01
STAT5 activation downstream of FLT3 ITD mutants 9 4.60e-01 1.42e-01 7.17e-01
Adipogenesis 95 1.69e-02 -1.42e-01 9.53e-02
Collagen degradation 42 1.12e-01 1.42e-01 3.35e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 1.17e-01 1.41e-01 3.43e-01
MAPK1/MAPK3 signaling 231 2.27e-04 1.41e-01 3.98e-03
G2/M DNA replication checkpoint 5 5.86e-01 -1.41e-01 7.95e-01
Respiratory syncytial virus (RSV) attachment and entry 19 2.89e-01 -1.41e-01 5.73e-01
Miscellaneous substrates 8 4.92e-01 1.40e-01 7.34e-01
Diseases of programmed cell death 58 6.47e-02 1.40e-01 2.37e-01
Protein methylation 15 3.48e-01 1.40e-01 6.36e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 5.69e-02 1.40e-01 2.18e-01
IRS-related events triggered by IGF1R 36 1.50e-01 -1.39e-01 4.00e-01
CREB3 factors activate genes 6 5.56e-01 1.39e-01 7.79e-01
Negative regulation of FLT3 15 3.52e-01 1.39e-01 6.41e-01
Response of Mtb to phagocytosis 22 2.62e-01 1.38e-01 5.46e-01
RHO GTPases Activate ROCKs 18 3.10e-01 1.38e-01 6.00e-01
Regulation of CDH11 Expression and Function 22 2.62e-01 -1.38e-01 5.46e-01
HDR through Homologous Recombination (HRR) 68 4.95e-02 -1.38e-01 1.98e-01
Nuclear Receptor transcription pathway 38 1.42e-01 -1.38e-01 3.85e-01
Suppression of apoptosis 7 5.28e-01 1.38e-01 7.62e-01
GABA receptor activation 36 1.54e-01 1.37e-01 4.08e-01
Regulation of endogenous retroelements 93 2.22e-02 -1.37e-01 1.15e-01
SLC15A4:TASL-dependent IRF5 activation 6 5.61e-01 -1.37e-01 7.82e-01
Intrinsic Pathway for Apoptosis 54 8.17e-02 1.37e-01 2.79e-01
Beta-catenin phosphorylation cascade 17 3.29e-01 1.37e-01 6.18e-01
VLDLR internalisation and degradation 15 3.60e-01 1.37e-01 6.45e-01
IGF1R signaling cascade 37 1.51e-01 -1.36e-01 4.04e-01
SUMOylation of transcription cofactors 44 1.18e-01 -1.36e-01 3.43e-01
Signaling by VEGF 99 1.94e-02 1.36e-01 1.05e-01
Defective RIPK1-mediated regulated necrosis 7 5.33e-01 -1.36e-01 7.67e-01
Maturation of nucleoprotein 9694631 15 3.62e-01 -1.36e-01 6.48e-01
DNA Double-Strand Break Repair 137 6.02e-03 -1.36e-01 4.60e-02
Hedgehog ‘off’ state 92 2.44e-02 1.36e-01 1.21e-01
Centrosome maturation 81 3.54e-02 -1.35e-01 1.57e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.54e-02 -1.35e-01 1.57e-01
Nucleotide salvage 21 2.86e-01 1.34e-01 5.70e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.03e-01 -1.34e-01 4.79e-01
PKR-mediated signaling 67 5.75e-02 -1.34e-01 2.19e-01
Nervous system development 478 5.20e-07 1.34e-01 2.99e-05
Glycosaminoglycan metabolism 98 2.21e-02 1.34e-01 1.14e-01
Mitotic Prometaphase 193 1.41e-03 -1.33e-01 1.52e-02
Peptide hormone metabolism 53 9.34e-02 1.33e-01 2.96e-01
RHOBTB1 GTPase cycle 23 2.69e-01 -1.33e-01 5.54e-01
DNA strand elongation 32 1.93e-01 -1.33e-01 4.67e-01
Regulation of Expression and Function of Type II Classical Cadherins 24 2.61e-01 -1.33e-01 5.46e-01
Regulation of Homotypic Cell-Cell Adhesion 24 2.61e-01 -1.33e-01 5.46e-01
Caspase activation via Death Receptors in the presence of ligand 16 3.59e-01 -1.32e-01 6.45e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 5.45e-01 -1.32e-01 7.73e-01
Macroautophagy 128 1.02e-02 1.32e-01 6.57e-02
Gap junction degradation 11 4.50e-01 1.31e-01 7.14e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 4.52e-01 -1.31e-01 7.14e-01
Defective EXT2 causes exostoses 2 11 4.52e-01 -1.31e-01 7.14e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 1.18e-01 -1.31e-01 3.43e-01
B-WICH complex positively regulates rRNA expression 45 1.30e-01 1.30e-01 3.65e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 3.83e-01 1.30e-01 6.66e-01
DNA Replication Pre-Initiation 103 2.26e-02 1.30e-01 1.15e-01
Gene expression (Transcription) 1404 3.49e-16 -1.30e-01 1.68e-13
Deadenylation-dependent mRNA decay 50 1.12e-01 -1.30e-01 3.37e-01
Cleavage of the damaged pyrimidine 27 2.45e-01 1.29e-01 5.31e-01
Depyrimidination 27 2.45e-01 1.29e-01 5.31e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 2.45e-01 1.29e-01 5.31e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 4.38e-01 1.29e-01 7.03e-01
EGFR downregulation 26 2.54e-01 1.29e-01 5.41e-01
FCERI mediated NF-kB activation 130 1.11e-02 1.29e-01 6.93e-02
Activated NOTCH1 Transmits Signal to the Nucleus 27 2.47e-01 1.29e-01 5.33e-01
Extracellular matrix organization 219 1.02e-03 1.29e-01 1.23e-02
Apoptotic factor-mediated response 19 3.31e-01 1.29e-01 6.20e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 3.45e-01 -1.29e-01 6.35e-01
Sphingolipid de novo biosynthesis 35 1.89e-01 1.28e-01 4.63e-01
Assembly and cell surface presentation of NMDA receptors 34 1.96e-01 1.28e-01 4.69e-01
Trafficking and processing of endosomal TLR 13 4.24e-01 -1.28e-01 6.90e-01
ERK/MAPK targets 22 3.00e-01 1.28e-01 5.85e-01
MET activates PTK2 signaling 23 2.90e-01 1.28e-01 5.74e-01
Pexophagy 10 4.85e-01 1.27e-01 7.33e-01
G alpha (i) signalling events 196 2.16e-03 1.27e-01 2.05e-02
Aquaporin-mediated transport 38 1.76e-01 1.27e-01 4.42e-01
RHOBTB GTPase Cycle 35 1.96e-01 -1.26e-01 4.69e-01
Nuclear events stimulated by ALK signaling in cancer 33 2.10e-01 -1.26e-01 4.87e-01
Constitutive Signaling by Overexpressed ERBB2 11 4.69e-01 -1.26e-01 7.20e-01
Tryptophan catabolism 12 4.51e-01 -1.26e-01 7.14e-01
Signaling by NTRK1 (TRKA) 102 2.84e-02 1.26e-01 1.36e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.34e-01 -1.26e-01 5.19e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.93e-01 1.25e-01 4.66e-01
Plasma lipoprotein remodeling 18 3.57e-01 1.25e-01 6.45e-01
Nectin/Necl trans heterodimerization 5 6.27e-01 1.25e-01 8.18e-01
Other semaphorin interactions 16 3.85e-01 1.25e-01 6.66e-01
Synthesis of very long-chain fatty acyl-CoAs 22 3.09e-01 1.25e-01 5.97e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 3.82e-03 1.25e-01 3.24e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 4.17e-01 -1.25e-01 6.85e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 1.06e-01 1.25e-01 3.23e-01
RNA Polymerase II Transcription 1197 3.43e-13 -1.25e-01 1.32e-10
Metabolism of nitric oxide: NOS3 activation and regulation 14 4.19e-01 -1.25e-01 6.85e-01
Activation of GABAB receptors 30 2.38e-01 1.25e-01 5.23e-01
GABA B receptor activation 30 2.38e-01 1.25e-01 5.23e-01
Metabolism of carbohydrates 241 9.06e-04 1.24e-01 1.15e-02
Apoptosis 158 7.12e-03 1.24e-01 5.26e-02
Epigenetic regulation of gene expression 264 5.26e-04 -1.24e-01 7.45e-03
mRNA Splicing 211 1.92e-03 -1.24e-01 1.90e-02
Processing of SMDT1 15 4.06e-01 1.24e-01 6.78e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.78e-01 1.24e-01 6.61e-01
mRNA Splicing - Major Pathway 203 2.41e-03 -1.24e-01 2.20e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 5.72e-01 1.23e-01 7.88e-01
Generic Transcription Pathway 1079 7.49e-12 -1.23e-01 2.41e-09
Mitotic Spindle Checkpoint 108 2.70e-02 -1.23e-01 1.30e-01
rRNA processing in the nucleus and cytosol 189 3.51e-03 1.23e-01 2.99e-02
Dissolution of Fibrin Clot 12 4.60e-01 1.23e-01 7.17e-01
FGFR2 ligand binding and activation 9 5.23e-01 -1.23e-01 7.61e-01
Trafficking of GluR2-containing AMPA receptors 11 4.81e-01 -1.23e-01 7.31e-01
Negative regulation of FGFR3 signaling 21 3.30e-01 1.23e-01 6.19e-01
Cargo trafficking to the periciliary membrane 48 1.41e-01 -1.23e-01 3.85e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 1.03e-01 1.23e-01 3.19e-01
Signaling by ALK fusions and activated point mutants 89 4.56e-02 -1.23e-01 1.86e-01
Signaling by ALK in cancer 89 4.56e-02 -1.23e-01 1.86e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 4.27e-01 1.23e-01 6.92e-01
Cilium Assembly 187 3.88e-03 -1.22e-01 3.28e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.82e-01 1.22e-01 7.32e-01
Acyl chain remodelling of PS 14 4.29e-01 1.22e-01 6.92e-01
G-protein beta:gamma signalling 29 2.56e-01 1.22e-01 5.41e-01
Listeria monocytogenes entry into host cells 17 3.84e-01 1.22e-01 6.66e-01
Metabolism 1827 5.50e-18 1.22e-01 5.30e-15
AKT phosphorylates targets in the cytosol 14 4.31e-01 1.22e-01 6.94e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.86e-01 -1.21e-01 7.33e-01
Interleukin-27 signaling 11 4.86e-01 -1.21e-01 7.33e-01
Signaling by NTRKs 116 2.42e-02 1.21e-01 1.21e-01
TICAM1-dependent activation of IRF3/IRF7 13 4.50e-01 1.21e-01 7.14e-01
PI-3K cascade:FGFR1 13 4.51e-01 -1.21e-01 7.14e-01
Syndecan interactions 25 2.97e-01 1.21e-01 5.81e-01
Platelet calcium homeostasis 22 3.28e-01 1.21e-01 6.17e-01
Association of TriC/CCT with target proteins during biosynthesis 35 2.17e-01 -1.21e-01 4.97e-01
mRNA 3’-end processing 57 1.16e-01 -1.20e-01 3.42e-01
Programmed Cell Death 187 4.59e-03 1.20e-01 3.71e-02
Defects in vitamin and cofactor metabolism 21 3.41e-01 -1.20e-01 6.29e-01
Pausing and recovery of Tat-mediated HIV elongation 30 2.55e-01 1.20e-01 5.41e-01
Tat-mediated HIV elongation arrest and recovery 30 2.55e-01 1.20e-01 5.41e-01
ARMS-mediated activation 6 6.11e-01 1.20e-01 8.13e-01
CASP8 activity is inhibited 11 4.91e-01 -1.20e-01 7.34e-01
Dimerization of procaspase-8 11 4.91e-01 -1.20e-01 7.34e-01
Regulation by c-FLIP 11 4.91e-01 -1.20e-01 7.34e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.31e-01 1.20e-01 6.20e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 3.80e-01 -1.19e-01 6.64e-01
Myogenesis 20 3.55e-01 -1.19e-01 6.45e-01
RUNX3 regulates p14-ARF 10 5.14e-01 1.19e-01 7.55e-01
GPER1 signaling 38 2.04e-01 1.19e-01 4.79e-01
Stimuli-sensing channels 80 6.54e-02 1.19e-01 2.38e-01
Activated NTRK2 signals through RAS 6 6.15e-01 -1.19e-01 8.13e-01
Activated NTRK3 signals through RAS 6 6.15e-01 -1.19e-01 8.13e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 4.11e-01 -1.19e-01 6.83e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.05e-01 -1.19e-01 5.90e-01
Inositol phosphate metabolism 42 1.85e-01 -1.18e-01 4.56e-01
Displacement of DNA glycosylase by APEX1 9 5.40e-01 1.18e-01 7.70e-01
tRNA modification in the nucleus and cytosol 43 1.80e-01 -1.18e-01 4.51e-01
Hemostasis 558 1.85e-06 1.18e-01 9.37e-05
Interleukin-12 signaling 44 1.76e-01 1.18e-01 4.42e-01
DNA Repair 289 5.56e-04 -1.18e-01 7.71e-03
Oxidative Stress Induced Senescence 77 7.37e-02 1.18e-01 2.59e-01
NRAGE signals death through JNK 52 1.43e-01 -1.17e-01 3.88e-01
ChREBP activates metabolic gene expression 7 5.92e-01 1.17e-01 7.98e-01
Interleukin-1 processing 8 5.66e-01 1.17e-01 7.83e-01
Keratan sulfate/keratin metabolism 28 2.84e-01 1.17e-01 5.70e-01
RND2 GTPase cycle 36 2.24e-01 -1.17e-01 5.05e-01
Processing of DNA double-strand break ends 69 9.29e-02 -1.17e-01 2.96e-01
Transcriptional regulation by RUNX1 170 8.55e-03 1.17e-01 6.03e-02
Proton-coupled monocarboxylate transport 6 6.20e-01 1.17e-01 8.15e-01
Downstream signaling events of B Cell Receptor (BCR) 68 9.66e-02 1.17e-01 3.04e-01
IRS-mediated signalling 35 2.33e-01 -1.16e-01 5.18e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.62e-01 1.16e-01 5.46e-01
Potassium Channels 64 1.08e-01 1.16e-01 3.27e-01
Synthesis of PIPs at the Golgi membrane 16 4.21e-01 -1.16e-01 6.86e-01
L1CAM interactions 101 4.37e-02 1.16e-01 1.81e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.22e-01 1.16e-01 6.86e-01
MAPK family signaling cascades 263 1.26e-03 1.16e-01 1.42e-02
RAC3 GTPase cycle 87 6.27e-02 1.15e-01 2.34e-01
Cell surface interactions at the vascular wall 173 8.83e-03 1.15e-01 6.08e-02
Interleukin-2 family signaling 38 2.19e-01 -1.15e-01 4.97e-01
FasL/ CD95L signaling 5 6.55e-01 -1.15e-01 8.39e-01
Signaling by FGFR 73 8.86e-02 1.15e-01 2.91e-01
Signaling by FGFR1 42 1.97e-01 1.15e-01 4.71e-01
Sema3A PAK dependent Axon repulsion 16 4.26e-01 1.15e-01 6.92e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.52e-01 1.15e-01 6.41e-01
Activation of PUMA and translocation to mitochondria 9 5.53e-01 -1.14e-01 7.76e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 2.88e-01 1.14e-01 5.72e-01
PI3K events in ERBB4 signaling 6 6.29e-01 -1.14e-01 8.18e-01
Neurofascin interactions 5 6.59e-01 1.14e-01 8.43e-01
Signaling by NOTCH3 42 2.02e-01 1.14e-01 4.79e-01
Signaling by BMP 23 3.46e-01 -1.13e-01 6.36e-01
Switching of origins to a post-replicative state 79 8.15e-02 1.13e-01 2.79e-01
Other interleukin signaling 19 3.93e-01 -1.13e-01 6.69e-01
Androgen biosynthesis 5 6.61e-01 1.13e-01 8.43e-01
C-type lectin receptors (CLRs) 118 3.43e-02 1.13e-01 1.54e-01
Influenza Infection 153 1.61e-02 1.13e-01 9.17e-02
A tetrasaccharide linker sequence is required for GAG synthesis 18 4.08e-01 1.13e-01 6.78e-01
Amino acid transport across the plasma membrane 25 3.30e-01 -1.13e-01 6.19e-01
Formation of Incision Complex in GG-NER 43 2.02e-01 1.12e-01 4.79e-01
Class A/1 (Rhodopsin-like receptors) 177 9.98e-03 1.12e-01 6.52e-02
PRC2 methylates histones and DNA 27 3.13e-01 1.12e-01 6.03e-01
Glutamate Neurotransmitter Release Cycle 19 3.98e-01 -1.12e-01 6.72e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.09e-01 1.12e-01 4.87e-01
HIV Transcription Elongation 42 2.09e-01 1.12e-01 4.87e-01
Tat-mediated elongation of the HIV-1 transcript 42 2.09e-01 1.12e-01 4.87e-01
Acyl chain remodelling of PG 11 5.23e-01 1.11e-01 7.61e-01
SLBP independent Processing of Histone Pre-mRNAs 10 5.44e-01 1.11e-01 7.72e-01
AMPK inhibits chREBP transcriptional activation activity 6 6.39e-01 1.11e-01 8.27e-01
Butyrophilin (BTN) family interactions 10 5.45e-01 -1.10e-01 7.73e-01
Erythropoietin activates STAT5 6 6.40e-01 1.10e-01 8.28e-01
Biological oxidations 143 2.29e-02 1.10e-01 1.17e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 6.14e-01 1.10e-01 8.13e-01
Late endosomal microautophagy 30 2.98e-01 1.10e-01 5.82e-01
Resolution of Sister Chromatid Cohesion 116 4.14e-02 -1.10e-01 1.74e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 4.63e-01 1.09e-01 7.17e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 4.63e-01 1.09e-01 7.17e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 4.63e-01 1.09e-01 7.17e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 4.63e-01 1.09e-01 7.17e-01
Signaling by CTNNB1 phospho-site mutants 15 4.63e-01 1.09e-01 7.17e-01
Signaling by GSK3beta mutants 15 4.63e-01 1.09e-01 7.17e-01
RHOV GTPase cycle 36 2.57e-01 -1.09e-01 5.42e-01
Signaling by Receptor Tyrosine Kinases 443 8.46e-05 1.09e-01 2.21e-03
Integrin cell surface interactions 65 1.29e-01 1.09e-01 3.64e-01
Signaling by ERBB2 KD Mutants 20 4.00e-01 -1.09e-01 6.74e-01
PI Metabolism 79 9.64e-02 -1.08e-01 3.04e-01
Zinc transporters 12 5.17e-01 -1.08e-01 7.58e-01
Signaling by ERBB2 in Cancer 21 3.92e-01 -1.08e-01 6.69e-01
Synthesis of Dolichyl-phosphate 6 6.47e-01 1.08e-01 8.32e-01
HIV Life Cycle 144 2.56e-02 -1.08e-01 1.26e-01
STING mediated induction of host immune responses 15 4.70e-01 -1.08e-01 7.20e-01
Transcriptional Regulation by E2F6 34 2.77e-01 -1.08e-01 5.66e-01
Activation of kainate receptors upon glutamate binding 26 3.42e-01 1.08e-01 6.32e-01
G2/M DNA damage checkpoint 66 1.32e-01 -1.07e-01 3.67e-01
Transport and synthesis of PAPS 6 6.51e-01 1.07e-01 8.35e-01
Phase 0 - rapid depolarisation 24 3.66e-01 -1.07e-01 6.52e-01
Formation of TC-NER Pre-Incision Complex 51 1.90e-01 1.06e-01 4.64e-01
IRAK4 deficiency (TLR2/4) 15 4.78e-01 1.06e-01 7.29e-01
Reactions specific to the complex N-glycan synthesis pathway 7 6.29e-01 1.05e-01 8.18e-01
Reelin signalling pathway 5 6.84e-01 1.05e-01 8.59e-01
SARS-CoV-1 activates/modulates innate immune responses 40 2.50e-01 -1.05e-01 5.37e-01
Signaling by SCF-KIT 40 2.50e-01 -1.05e-01 5.37e-01
RNA Polymerase I Transcription Initiation 47 2.12e-01 -1.05e-01 4.92e-01
Keratan sulfate biosynthesis 20 4.17e-01 -1.05e-01 6.85e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.98e-01 1.05e-01 7.40e-01
Signaling by FGFR2 IIIa TM 18 4.43e-01 1.04e-01 7.06e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 6.33e-01 1.04e-01 8.22e-01
Striated Muscle Contraction 27 3.48e-01 1.04e-01 6.36e-01
E2F mediated regulation of DNA replication 22 3.97e-01 -1.04e-01 6.72e-01
NoRC negatively regulates rRNA expression 60 1.63e-01 1.04e-01 4.23e-01
PI3K Cascade 31 3.16e-01 -1.04e-01 6.06e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 3.90e-01 -1.04e-01 6.67e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 3.90e-01 -1.04e-01 6.67e-01
Interleukin-4 and Interleukin-13 signaling 92 8.76e-02 1.03e-01 2.89e-01
Synthesis of diphthamide-EEF2 8 6.14e-01 1.03e-01 8.13e-01
MET activates PI3K/AKT signaling 5 6.91e-01 -1.03e-01 8.65e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 5.06e-01 -1.03e-01 7.47e-01
Phase 3 - rapid repolarisation 6 6.63e-01 -1.03e-01 8.44e-01
tRNA modification in the mitochondrion 9 5.94e-01 1.03e-01 8.01e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 2.56e-01 -1.03e-01 5.41e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 3.66e-01 1.02e-01 6.52e-01
RHO GTPases Activate WASPs and WAVEs 35 2.96e-01 1.02e-01 5.81e-01
Glycerophospholipid biosynthesis 105 7.10e-02 1.02e-01 2.52e-01
Gastrulation 76 1.25e-01 1.02e-01 3.57e-01
mRNA Splicing - Minor Pathway 50 2.13e-01 1.02e-01 4.93e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 6.94e-01 -1.02e-01 8.66e-01
DNA Damage Recognition in GG-NER 38 2.79e-01 1.02e-01 5.68e-01
Cellular responses to stimuli 778 1.46e-06 1.01e-01 7.62e-05
EGFR Transactivation by Gastrin 7 6.42e-01 -1.01e-01 8.30e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 5.28e-01 1.01e-01 7.62e-01
Free fatty acids regulate insulin secretion 10 5.81e-01 1.01e-01 7.91e-01
Signaling by Interleukins 390 6.43e-04 1.01e-01 8.73e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 4.86e-01 1.01e-01 7.33e-01
Peroxisomal lipid metabolism 27 3.65e-01 1.01e-01 6.51e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 4.86e-01 1.01e-01 7.33e-01
RAF-independent MAPK1/3 activation 22 4.15e-01 1.00e-01 6.85e-01
NADE modulates death signalling 5 6.98e-01 1.00e-01 8.67e-01
Inhibition of Signaling by Overexpressed EGFR 5 6.99e-01 9.99e-02 8.67e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 6.99e-01 9.99e-02 8.67e-01
Autophagy 142 4.04e-02 9.96e-02 1.72e-01
Na+/Cl- dependent neurotransmitter transporters 8 6.27e-01 9.92e-02 8.18e-01
Nucleotide biosynthesis 12 5.53e-01 -9.90e-02 7.76e-01
Nef Mediated CD8 Down-regulation 7 6.51e-01 9.87e-02 8.35e-01
Metabolism of nucleotides 85 1.16e-01 9.86e-02 3.42e-01
Regulation of Complement cascade 97 9.35e-02 9.85e-02 2.96e-01
MECP2 regulates neuronal receptors and channels 14 5.23e-01 -9.85e-02 7.61e-01
Leading Strand Synthesis 14 5.23e-01 -9.85e-02 7.61e-01
Polymerase switching 14 5.23e-01 -9.85e-02 7.61e-01
Budding and maturation of HIV virion 26 3.85e-01 9.84e-02 6.66e-01
ADP signalling through P2Y purinoceptor 1 21 4.35e-01 9.84e-02 6.99e-01
Signaling by MET 68 1.61e-01 9.83e-02 4.20e-01
Signaling by CSF3 (G-CSF) 29 3.60e-01 9.82e-02 6.45e-01
Serine biosynthesis 8 6.32e-01 9.78e-02 8.22e-01
Homology Directed Repair 110 7.67e-02 -9.77e-02 2.67e-01
ATF6 (ATF6-alpha) activates chaperones 12 5.58e-01 -9.76e-02 7.81e-01
Diseases of metabolism 204 1.62e-02 9.76e-02 9.22e-02
HSF1 activation 26 3.91e-01 -9.72e-02 6.68e-01
RHOH GTPase cycle 33 3.34e-01 9.72e-02 6.23e-01
DAP12 interactions 39 2.94e-01 -9.72e-02 5.79e-01
Signal amplification 28 3.74e-01 9.71e-02 6.60e-01
Generation of second messenger molecules 38 3.02e-01 -9.68e-02 5.86e-01
Cellular responses to stress 697 1.32e-05 9.68e-02 5.09e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 3.75e-01 9.68e-02 6.60e-01
Cellular responses to mechanical stimuli 82 1.30e-01 9.67e-02 3.65e-01
Response of endothelial cells to shear stress 82 1.30e-01 9.67e-02 3.65e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 3.94e-01 9.66e-02 6.69e-01
RHOJ GTPase cycle 49 2.42e-01 9.66e-02 5.28e-01
Zinc influx into cells by the SLC39 gene family 9 6.17e-01 9.63e-02 8.13e-01
Hedgehog ‘on’ state 66 1.77e-01 9.61e-02 4.43e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.88e-01 9.60e-02 6.67e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.88e-01 9.60e-02 6.67e-01
Tandem pore domain potassium channels 5 7.10e-01 -9.59e-02 8.72e-01
Degradation of the extracellular matrix 96 1.05e-01 9.58e-02 3.23e-01
Scavenging of heme from plasma 71 1.63e-01 9.57e-02 4.24e-01
Notch-HLH transcription pathway 28 3.86e-01 -9.47e-02 6.66e-01
Biotin transport and metabolism 11 5.87e-01 9.47e-02 7.95e-01
Dopamine Neurotransmitter Release Cycle 18 4.87e-01 -9.46e-02 7.33e-01
PKA-mediated phosphorylation of CREB 17 4.99e-01 9.46e-02 7.40e-01
CaMK IV-mediated phosphorylation of CREB 9 6.23e-01 -9.45e-02 8.16e-01
Regulation of TLR by endogenous ligand 15 5.26e-01 9.45e-02 7.61e-01
Negative regulation of FGFR4 signaling 22 4.43e-01 9.45e-02 7.06e-01
DNA Replication 128 6.51e-02 9.44e-02 2.38e-01
Defective B4GALT7 causes EDS, progeroid type 12 5.71e-01 -9.44e-02 7.88e-01
Signaling by Activin 13 5.57e-01 9.42e-02 7.79e-01
RNA polymerase II transcribes snRNA genes 71 1.71e-01 -9.39e-02 4.36e-01
NCAM1 interactions 26 4.08e-01 -9.38e-02 6.78e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 6.26e-01 -9.38e-02 8.18e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 2.56e-01 -9.37e-02 5.41e-01
Phospholipase C-mediated cascade: FGFR1 8 6.47e-01 9.36e-02 8.32e-01
Cyclin D associated events in G1 47 2.70e-01 9.31e-02 5.54e-01
G1 Phase 47 2.70e-01 9.31e-02 5.54e-01
Synthesis of PIPs at the plasma membrane 52 2.46e-01 -9.30e-02 5.32e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 7.19e-01 9.29e-02 8.75e-01
WNT5A-dependent internalization of FZD4 13 5.63e-01 -9.27e-02 7.82e-01
Fanconi Anemia Pathway 36 3.36e-01 -9.27e-02 6.25e-01
RNA Polymerase III Transcription Termination 22 4.53e-01 9.25e-02 7.14e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 6.95e-01 -9.25e-02 8.66e-01
SARS-CoV-1-host interactions 94 1.21e-01 9.25e-02 3.49e-01
Signaling by NOTCH 173 3.59e-02 9.24e-02 1.58e-01
Pregnenolone biosynthesis 10 6.13e-01 9.24e-02 8.13e-01
RAB geranylgeranylation 63 2.05e-01 9.23e-02 4.81e-01
SUMOylation of DNA methylation proteins 16 5.24e-01 -9.20e-02 7.61e-01
Receptor-type tyrosine-protein phosphatases 11 5.98e-01 9.19e-02 8.04e-01
LDL clearance 17 5.13e-01 9.16e-02 7.55e-01
APC-Cdc20 mediated degradation of Nek2A 26 4.21e-01 9.12e-02 6.86e-01
CTLA4 inhibitory signaling 21 4.70e-01 9.11e-02 7.20e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 4.92e-01 9.11e-02 7.34e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 5.18e-01 -9.06e-02 7.59e-01
Synthesis of PI 5 7.26e-01 -9.04e-02 8.81e-01
MAP kinase activation 63 2.15e-01 9.03e-02 4.95e-01
HS-GAG degradation 20 4.86e-01 9.00e-02 7.33e-01
EML4 and NUDC in mitotic spindle formation 107 1.08e-01 -8.99e-02 3.28e-01
Regulation of signaling by CBL 22 4.66e-01 -8.98e-02 7.20e-01
Late Phase of HIV Life Cycle 131 7.63e-02 -8.97e-02 2.66e-01
RAS signaling downstream of NF1 loss-of-function variants 7 6.81e-01 -8.97e-02 8.58e-01
ABC transporters in lipid homeostasis 14 5.62e-01 -8.96e-02 7.82e-01
Late SARS-CoV-2 Infection Events 64 2.15e-01 8.96e-02 4.95e-01
PIWI-interacting RNA (piRNA) biogenesis 23 4.57e-01 8.95e-02 7.16e-01
Regulation of IFNG signaling 14 5.62e-01 8.95e-02 7.82e-01
Triglyceride catabolism 15 5.49e-01 8.95e-02 7.73e-01
Sensory processing of sound by inner hair cells of the cochlea 54 2.56e-01 -8.93e-02 5.41e-01
Metalloprotease DUBs 20 4.89e-01 8.93e-02 7.34e-01
CD28 dependent PI3K/Akt signaling 22 4.69e-01 -8.92e-02 7.20e-01
RHO GTPases activate PAKs 20 4.91e-01 8.91e-02 7.34e-01
Type I hemidesmosome assembly 8 6.63e-01 -8.90e-02 8.44e-01
MET activates RAS signaling 10 6.28e-01 8.86e-02 8.18e-01
Mitochondrial unfolded protein response (UPRmt) 17 5.28e-01 -8.84e-02 7.62e-01
Organelle biogenesis and maintenance 278 1.14e-02 -8.82e-02 7.04e-02
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.74e-01 8.81e-02 6.60e-01
rRNA modification in the nucleus and cytosol 60 2.39e-01 -8.79e-02 5.24e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 6.88e-01 8.78e-02 8.62e-01
Platelet homeostasis 69 2.08e-01 8.76e-02 4.86e-01
Signal regulatory protein family interactions 13 5.85e-01 8.74e-02 7.95e-01
Activation of HOX genes during differentiation 70 2.07e-01 8.72e-02 4.84e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 2.07e-01 8.72e-02 4.84e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 5.86e-01 8.72e-02 7.95e-01
Alternative complement activation 5 7.36e-01 8.71e-02 8.84e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 1.47e-01 8.70e-02 3.94e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 5.35e-01 -8.69e-02 7.68e-01
Metabolism of fat-soluble vitamins 28 4.28e-01 8.66e-02 6.92e-01
Complement cascade 101 1.33e-01 8.66e-02 3.68e-01
PTEN Regulation 127 9.33e-02 8.62e-02 2.96e-01
VEGFR2 mediated vascular permeability 25 4.56e-01 8.62e-02 7.16e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.69e-01 -8.61e-02 5.54e-01
APC truncation mutants have impaired AXIN binding 14 5.78e-01 8.59e-02 7.89e-01
AXIN missense mutants destabilize the destruction complex 14 5.78e-01 8.59e-02 7.89e-01
Signaling by AMER1 mutants 14 5.78e-01 8.59e-02 7.89e-01
Signaling by APC mutants 14 5.78e-01 8.59e-02 7.89e-01
Signaling by AXIN mutants 14 5.78e-01 8.59e-02 7.89e-01
Truncations of AMER1 destabilize the destruction complex 14 5.78e-01 8.59e-02 7.89e-01
Regulation of CDH11 gene transcription 5 7.40e-01 8.58e-02 8.85e-01
Maturation of spike protein 9683686 5 7.40e-01 8.57e-02 8.85e-01
Signaling by FGFR2 61 2.48e-01 8.56e-02 5.35e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.17e-01 8.56e-02 6.85e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.15e-01 -8.55e-02 6.05e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.27e-01 8.54e-02 6.16e-01
Nephrin family interactions 20 5.11e-01 -8.50e-02 7.54e-01
Downregulation of ERBB2 signaling 24 4.72e-01 8.49e-02 7.22e-01
Transport of small molecules 556 6.25e-04 8.48e-02 8.54e-03
EPH-Ephrin signaling 81 1.87e-01 8.48e-02 4.59e-01
Visual phototransduction 61 2.52e-01 8.48e-02 5.38e-01
Signaling by BRAF and RAF1 fusions 60 2.58e-01 8.45e-02 5.42e-01
Sialic acid metabolism 28 4.39e-01 -8.44e-02 7.04e-01
Defective HLCS causes multiple carboxylase deficiency 7 7.00e-01 -8.42e-02 8.67e-01
Negative regulation of FGFR2 signaling 24 4.76e-01 8.40e-02 7.28e-01
RHOBTB3 ATPase cycle 10 6.47e-01 8.35e-02 8.32e-01
Regulation of HMOX1 expression and activity 5 7.47e-01 -8.34e-02 8.90e-01
Nef and signal transduction 8 6.83e-01 -8.34e-02 8.58e-01
MITF-M-dependent gene expression 84 1.87e-01 -8.34e-02 4.59e-01
Activation of Matrix Metalloproteinases 22 4.99e-01 8.32e-02 7.40e-01
RNA Polymerase III Chain Elongation 18 5.41e-01 8.32e-02 7.70e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 7.48e-01 -8.31e-02 8.90e-01
HIV elongation arrest and recovery 32 4.16e-01 8.31e-02 6.85e-01
Pausing and recovery of HIV elongation 32 4.16e-01 8.31e-02 6.85e-01
Mitotic Prophase 96 1.60e-01 -8.30e-02 4.19e-01
Signaling by Hedgehog 121 1.15e-01 8.30e-02 3.41e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.04e-01 -8.27e-02 6.75e-01
RND1 GTPase cycle 36 3.93e-01 -8.22e-02 6.69e-01
FGFR2b ligand binding and activation 6 7.28e-01 -8.20e-02 8.81e-01
Cell-cell junction organization 57 2.86e-01 -8.17e-02 5.70e-01
Muscle contraction 145 8.97e-02 8.16e-02 2.92e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 5.18e-01 -8.15e-02 7.59e-01
Mitochondrial Uncoupling 6 7.30e-01 -8.14e-02 8.81e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 5.50e-01 -8.13e-02 7.75e-01
Leishmania infection 213 4.09e-02 8.13e-02 1.73e-01
Parasitic Infection Pathways 213 4.09e-02 8.13e-02 1.73e-01
Nitric oxide stimulates guanylate cyclase 15 5.86e-01 -8.12e-02 7.95e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 6.74e-01 -8.11e-02 8.54e-01
Transcriptional Regulation by VENTX 39 3.82e-01 -8.09e-02 6.66e-01
Post-translational modification: synthesis of GPI-anchored proteins 60 2.80e-01 8.07e-02 5.68e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 6.15e-01 -8.05e-02 8.13e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 6.16e-01 8.03e-02 8.13e-01
Regulation of innate immune responses to cytosolic DNA 14 6.03e-01 8.03e-02 8.08e-01
Lewis blood group biosynthesis 13 6.17e-01 8.02e-02 8.13e-01
RIP-mediated NFkB activation via ZBP1 17 5.69e-01 -7.99e-02 7.86e-01
Bacterial Infection Pathways 65 2.67e-01 7.97e-02 5.51e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 5.60e-01 7.93e-02 7.82e-01
Class I peroxisomal membrane protein import 20 5.39e-01 -7.93e-02 7.70e-01
Erythropoietin activates RAS 13 6.21e-01 7.93e-02 8.15e-01
Translation of Structural Proteins 9683701 29 4.60e-01 -7.92e-02 7.17e-01
Signaling by LTK in cancer 7 7.17e-01 -7.92e-02 8.73e-01
Tight junction interactions 17 5.74e-01 -7.87e-02 7.89e-01
Adherens junctions interactions 38 4.02e-01 -7.86e-02 6.74e-01
Interleukin-17 signaling 68 2.63e-01 7.85e-02 5.48e-01
GPCR ligand binding 245 3.45e-02 7.84e-02 1.55e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 5.34e-01 7.83e-02 7.68e-01
RNA Polymerase II Transcription Termination 66 2.71e-01 -7.83e-02 5.56e-01
Oncogenic MAPK signaling 76 2.39e-01 7.81e-02 5.24e-01
Beta-catenin independent WNT signaling 126 1.32e-01 7.78e-02 3.67e-01
mRNA Capping 29 4.71e-01 7.74e-02 7.21e-01
O-linked glycosylation of mucins 47 3.59e-01 7.74e-02 6.45e-01
RNA Polymerase I Promoter Clearance 64 2.85e-01 7.72e-02 5.70e-01
RNA Polymerase I Transcription 64 2.85e-01 7.72e-02 5.70e-01
The NLRP3 inflammasome 16 5.93e-01 7.72e-02 7.99e-01
Interleukin receptor SHC signaling 23 5.22e-01 -7.72e-02 7.61e-01
CDH11 homotypic and heterotypic interactions 5 7.66e-01 -7.70e-02 9.02e-01
Processing of Intronless Pre-mRNAs 20 5.52e-01 -7.69e-02 7.76e-01
Protein folding 83 2.26e-01 7.68e-02 5.07e-01
Signaling by TGFB family members 137 1.21e-01 -7.67e-02 3.49e-01
Cell Cycle 611 1.21e-03 -7.66e-02 1.38e-02
Gene Silencing by RNA 87 2.18e-01 -7.64e-02 4.97e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.70e-01 7.64e-02 4.35e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 1.70e-01 7.64e-02 4.35e-01
G1/S-Specific Transcription 29 4.78e-01 -7.61e-02 7.29e-01
Presynaptic depolarization and calcium channel opening 8 7.09e-01 -7.61e-02 8.72e-01
G beta:gamma signalling through PI3Kgamma 22 5.37e-01 7.60e-02 7.70e-01
Sensory processing of sound 58 3.18e-01 -7.59e-02 6.07e-01
ADORA2B mediated anti-inflammatory cytokines production 36 4.31e-01 7.58e-02 6.94e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 7.70e-01 7.55e-02 9.03e-01
Fc epsilon receptor (FCERI) signaling 180 8.11e-02 7.54e-02 2.79e-01
Vitamin C (ascorbate) metabolism 8 7.12e-01 -7.53e-02 8.72e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 7.13e-01 -7.51e-02 8.72e-01
MicroRNA (miRNA) biogenesis 24 5.24e-01 7.51e-02 7.61e-01
NCAM signaling for neurite out-growth 47 3.75e-01 -7.48e-02 6.60e-01
FGFR1c ligand binding and activation 8 7.14e-01 -7.48e-02 8.72e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 6.05e-01 -7.48e-02 8.09e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 3.57e-01 7.46e-02 6.45e-01
PERK regulates gene expression 31 4.74e-01 7.43e-02 7.25e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 4.29e-01 7.42e-02 6.92e-01
Nucleosome assembly 38 4.29e-01 7.42e-02 6.92e-01
Ion channel transport 141 1.28e-01 7.42e-02 3.63e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 51 3.60e-01 7.41e-02 6.45e-01
Protein hydroxylation 17 5.99e-01 7.37e-02 8.04e-01
Signaling by FGFR2 in disease 33 4.64e-01 -7.36e-02 7.19e-01
Recruitment of NuMA to mitotic centrosomes 88 2.34e-01 -7.34e-02 5.19e-01
Loss of Function of TGFBR1 in Cancer 7 7.38e-01 -7.31e-02 8.84e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 5.36e-01 7.30e-02 7.69e-01
Defective pyroptosis 27 5.12e-01 7.29e-02 7.55e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 4.97e-01 7.29e-02 7.40e-01
Transcriptional regulation of testis differentiation 5 7.78e-01 -7.28e-02 9.05e-01
Vitamin B5 (pantothenate) metabolism 20 5.73e-01 7.28e-02 7.89e-01
RHO GTPase Effectors 259 4.41e-02 7.27e-02 1.82e-01
Suppression of phagosomal maturation 12 6.64e-01 7.25e-02 8.44e-01
Early SARS-CoV-2 Infection Events 32 4.78e-01 -7.24e-02 7.29e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 3.77e-01 7.23e-02 6.61e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.79e-01 7.21e-02 8.58e-01
Transcriptional Regulation by NPAS4 27 5.17e-01 -7.21e-02 7.58e-01
Retrograde transport at the Trans-Golgi-Network 49 3.83e-01 -7.20e-02 6.66e-01
Signaling by WNT in cancer 30 4.95e-01 7.19e-02 7.38e-01
Toll Like Receptor 2 (TLR2) Cascade 109 1.95e-01 7.18e-02 4.68e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 1.95e-01 7.18e-02 4.68e-01
Signaling by the B Cell Receptor (BCR) 151 1.28e-01 7.18e-02 3.62e-01
Apoptosis induced DNA fragmentation 10 6.94e-01 7.18e-02 8.66e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 3.58e-01 7.17e-02 6.45e-01
DNA Double Strand Break Response 47 3.95e-01 -7.17e-02 6.70e-01
Aspartate and asparagine metabolism 9 7.10e-01 7.15e-02 8.72e-01
TRAF6 mediated NF-kB activation 23 5.54e-01 -7.12e-02 7.78e-01
Integration of energy metabolism 88 2.49e-01 7.12e-02 5.36e-01
TCF dependent signaling in response to WNT 152 1.30e-01 7.12e-02 3.65e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.10e-01 -7.11e-02 4.88e-01
Sensory perception of taste 22 5.65e-01 -7.09e-02 7.83e-01
Signaling by NTRK2 (TRKB) 20 5.84e-01 -7.08e-02 7.95e-01
Collagen chain trimerization 27 5.26e-01 -7.05e-02 7.61e-01
tRNA processing 128 1.69e-01 -7.05e-02 4.33e-01
Branched-chain amino acid catabolism 21 5.76e-01 7.04e-02 7.89e-01
Folding of actin by CCT/TriC 10 7.01e-01 7.01e-02 8.68e-01
Mitochondrial iron-sulfur cluster biogenesis 13 6.62e-01 7.00e-02 8.44e-01
Role of LAT2/NTAL/LAB on calcium mobilization 78 2.85e-01 7.00e-02 5.70e-01
G alpha (12/13) signalling events 68 3.20e-01 -6.97e-02 6.10e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.47e-01 -6.96e-02 7.73e-01
NOD1/2 Signaling Pathway 36 4.70e-01 6.96e-02 7.20e-01
Initiation of Nuclear Envelope (NE) Reformation 19 6.00e-01 -6.95e-02 8.05e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 5.25e-01 -6.94e-02 7.61e-01
Reversible hydration of carbon dioxide 8 7.35e-01 6.91e-02 8.84e-01
Signaling by Insulin receptor 63 3.44e-01 6.90e-02 6.34e-01
TRP channels 22 5.76e-01 6.89e-02 7.89e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 7.52e-01 6.89e-02 8.93e-01
Phase 4 - resting membrane potential 9 7.21e-01 6.88e-02 8.77e-01
Glucagon signaling in metabolic regulation 26 5.44e-01 6.88e-02 7.72e-01
Vitamin B2 (riboflavin) metabolism 6 7.70e-01 6.88e-02 9.03e-01
Regulation of TNFR1 signaling 47 4.16e-01 6.86e-02 6.85e-01
Paracetamol ADME 19 6.05e-01 6.86e-02 8.09e-01
Translesion Synthesis by POLH 18 6.18e-01 6.79e-02 8.13e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 4.69e-01 -6.79e-02 7.20e-01
Long-term potentiation 18 6.18e-01 6.79e-02 8.13e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 2.82e-01 6.75e-02 5.70e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 2.82e-01 6.75e-02 5.70e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 2.82e-01 6.75e-02 5.70e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 3.02e-01 -6.72e-02 5.86e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 4.42e-01 -6.69e-02 7.06e-01
trans-Golgi Network Vesicle Budding 69 3.37e-01 6.68e-02 6.26e-01
Cytoprotection by HMOX1 53 4.01e-01 6.67e-02 6.74e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 6.00e-01 6.62e-02 8.05e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 6.18e-01 -6.62e-02 8.13e-01
PIP3 activates AKT signaling 234 8.15e-02 6.61e-02 2.79e-01
Assembly of collagen fibrils and other multimeric structures 42 4.59e-01 6.61e-02 7.17e-01
Phase I - Functionalization of compounds 68 3.47e-01 6.60e-02 6.36e-01
Cytosolic iron-sulfur cluster assembly 13 6.82e-01 6.56e-02 8.58e-01
Downstream TCR signaling 89 2.85e-01 6.56e-02 5.70e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 7.82e-01 -6.53e-02 9.07e-01
Neurexins and neuroligins 38 4.87e-01 -6.51e-02 7.33e-01
Negative epigenetic regulation of rRNA expression 63 3.71e-01 6.51e-02 6.58e-01
Lipophagy 7 7.66e-01 -6.49e-02 9.02e-01
Reduction of cytosolic Ca++ levels 9 7.36e-01 6.49e-02 8.84e-01
DNA Damage Bypass 47 4.43e-01 -6.47e-02 7.06e-01
Wax and plasmalogen biosynthesis 5 8.03e-01 6.45e-02 9.16e-01
Defective B3GAT3 causes JDSSDHD 12 7.01e-01 -6.39e-02 8.68e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 6.58e-01 -6.39e-02 8.42e-01
Cell Cycle, Mitotic 488 1.61e-02 -6.36e-02 9.17e-02
PTK6 promotes HIF1A stabilization 6 7.87e-01 6.36e-02 9.10e-01
Negative regulation of the PI3K/AKT network 91 2.94e-01 6.36e-02 5.79e-01
Plasma lipoprotein assembly 10 7.29e-01 -6.34e-02 8.81e-01
CD28 dependent Vav1 pathway 12 7.04e-01 -6.33e-02 8.70e-01
Nucleotide catabolism 28 5.63e-01 6.32e-02 7.82e-01
Formation of definitive endoderm 9 7.43e-01 -6.31e-02 8.88e-01
G2 Phase 5 8.07e-01 6.29e-02 9.18e-01
Interleukin-37 signaling 19 6.37e-01 6.26e-02 8.25e-01
G beta:gamma signalling through CDC42 17 6.55e-01 6.26e-02 8.39e-01
Cellular hexose transport 15 6.75e-01 -6.25e-02 8.54e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 6.47e-01 -6.24e-02 8.32e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 6.47e-01 -6.24e-02 8.32e-01
Release of apoptotic factors from the mitochondria 6 7.91e-01 6.24e-02 9.13e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 6.86e-01 6.23e-02 8.61e-01
Downstream signal transduction 27 5.75e-01 -6.23e-02 7.89e-01
The phototransduction cascade 27 5.79e-01 6.18e-02 7.90e-01
Immune System 1841 1.15e-05 6.17e-02 4.51e-04
Diseases associated with glycosylation precursor biosynthesis 15 6.80e-01 6.14e-02 8.58e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 5.49e-01 6.13e-02 7.73e-01
Synthesis of PE 12 7.13e-01 6.13e-02 8.72e-01
Developmental Biology 924 1.67e-03 6.10e-02 1.75e-02
Formation of the beta-catenin:TCF transactivating complex 44 4.84e-01 -6.10e-02 7.33e-01
Retinoid metabolism and transport 25 5.98e-01 6.09e-02 8.04e-01
FGFR1 ligand binding and activation 10 7.39e-01 6.08e-02 8.85e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.06e-01 -6.04e-02 8.71e-01
Interleukin-10 signaling 39 5.14e-01 6.04e-02 7.55e-01
Downstream signaling of activated FGFR1 22 6.25e-01 -6.01e-02 8.17e-01
Vitamin D (calciferol) metabolism 11 7.31e-01 -5.99e-02 8.81e-01
Nuclear Envelope (NE) Reassembly 68 3.93e-01 -5.99e-02 6.69e-01
Miscellaneous transport and binding events 20 6.43e-01 5.99e-02 8.30e-01
Synthesis of DNA 108 2.84e-01 5.97e-02 5.70e-01
Intracellular signaling by second messengers 267 9.34e-02 5.96e-02 2.96e-01
Adenylate cyclase inhibitory pathway 11 7.32e-01 5.96e-02 8.82e-01
Clathrin-mediated endocytosis 126 2.49e-01 5.95e-02 5.36e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 6.00e-01 -5.94e-02 8.05e-01
Signaling by activated point mutants of FGFR1 5 8.19e-01 -5.92e-02 9.23e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 4.56e-01 5.91e-02 7.16e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 4.56e-01 5.91e-02 7.16e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 4.56e-01 5.91e-02 7.16e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 4.56e-01 5.91e-02 7.16e-01
Signaling by NOTCH1 in Cancer 53 4.56e-01 5.91e-02 7.16e-01
Meiosis 67 4.03e-01 -5.91e-02 6.74e-01
Collagen formation 64 4.15e-01 5.90e-02 6.85e-01
NrCAM interactions 6 8.03e-01 5.89e-02 9.16e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 7.13e-01 -5.88e-02 8.72e-01
Maternal to zygotic transition (MZT) 72 3.88e-01 5.88e-02 6.67e-01
Chaperonin-mediated protein folding 77 3.75e-01 5.85e-02 6.60e-01
Post NMDA receptor activation events 64 4.19e-01 5.84e-02 6.86e-01
Interleukin-12 family signaling 53 4.63e-01 5.83e-02 7.17e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 3.56e-01 5.82e-02 6.45e-01
Transcription of E2F targets under negative control by DREAM complex 19 6.61e-01 -5.82e-02 8.43e-01
Regulation of pyruvate metabolism 32 5.72e-01 5.78e-02 7.88e-01
Initial triggering of complement 80 3.72e-01 5.78e-02 6.58e-01
HS-GAG biosynthesis 21 6.47e-01 -5.78e-02 8.32e-01
Transport of bile salts and organic acids, metal ions and amine compounds 53 4.68e-01 5.77e-02 7.20e-01
Nicotinate metabolism 27 6.05e-01 -5.75e-02 8.09e-01
Interleukin-7 signaling 21 6.49e-01 5.74e-02 8.34e-01
Metabolism of proteins 1775 5.93e-05 5.74e-02 1.79e-03
Purine salvage 12 7.31e-01 -5.74e-02 8.81e-01
Formation of the active cofactor, UDP-glucuronate 5 8.24e-01 5.73e-02 9.27e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 5.59e-01 5.71e-02 7.81e-01
Toll Like Receptor 4 (TLR4) Cascade 138 2.48e-01 5.69e-02 5.36e-01
Ca-dependent events 30 5.91e-01 5.66e-02 7.98e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 7.69e-01 -5.65e-02 9.03e-01
Regulation of CDH11 function 9 7.69e-01 5.65e-02 9.03e-01
G1/S Transition 120 2.86e-01 5.64e-02 5.70e-01
Fatty acyl-CoA biosynthesis 35 5.64e-01 5.63e-02 7.83e-01
EGFR interacts with phospholipase C-gamma 6 8.11e-01 5.62e-02 9.19e-01
Activation of gene expression by SREBF (SREBP) 42 5.28e-01 -5.62e-02 7.62e-01
FRS-mediated FGFR1 signaling 15 7.07e-01 -5.61e-02 8.71e-01
Triglyceride metabolism 24 6.35e-01 5.60e-02 8.23e-01
TCR signaling 110 3.13e-01 5.57e-02 6.03e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 7.99e-01 5.57e-02 9.15e-01
Synaptic adhesion-like molecules 17 6.92e-01 -5.54e-02 8.66e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 5.25e-01 -5.53e-02 7.61e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 6.76e-01 -5.53e-02 8.55e-01
Mitotic G1 phase and G1/S transition 138 2.62e-01 5.53e-02 5.46e-01
Methylation 13 7.31e-01 -5.52e-02 8.81e-01
Classical antibody-mediated complement activation 70 4.26e-01 5.50e-02 6.92e-01
Creation of C4 and C2 activators 72 4.21e-01 5.49e-02 6.86e-01
Nef Mediated CD4 Down-regulation 9 7.76e-01 5.48e-02 9.04e-01
ER Quality Control Compartment (ERQC) 21 6.64e-01 5.48e-02 8.44e-01
Plasma lipoprotein clearance 32 5.92e-01 5.48e-02 7.98e-01
GAB1 signalosome 14 7.24e-01 -5.46e-02 8.79e-01
RAF activation 33 5.88e-01 5.45e-02 7.96e-01
Tie2 Signaling 16 7.07e-01 -5.42e-02 8.71e-01
TAK1-dependent IKK and NF-kappa-B activation 43 5.40e-01 5.39e-02 7.70e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.22e-01 -5.39e-02 8.16e-01
Maturation of spike protein 9694548 36 5.76e-01 5.38e-02 7.89e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 7.48e-01 -5.36e-02 8.90e-01
MITF-M-regulated melanocyte development 113 3.25e-01 -5.36e-02 6.15e-01
TP53 Regulates Transcription of Cell Death Genes 43 5.46e-01 5.33e-02 7.73e-01
Signaling by TGF-beta Receptor Complex 90 3.84e-01 -5.31e-02 6.66e-01
FGFR1b ligand binding and activation 5 8.37e-01 -5.30e-02 9.33e-01
Organic anion transporters 7 8.08e-01 -5.29e-02 9.18e-01
MTOR signalling 39 5.69e-01 5.27e-02 7.86e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 188 2.13e-01 5.27e-02 4.92e-01
Cell death signalling via NRAGE, NRIF and NADE 69 4.57e-01 -5.18e-02 7.16e-01
CD22 mediated BCR regulation 59 4.92e-01 5.18e-02 7.34e-01
Intraflagellar transport 47 5.40e-01 -5.16e-02 7.70e-01
RUNX3 regulates NOTCH signaling 14 7.39e-01 -5.14e-02 8.85e-01
NFE2L2 regulating tumorigenic genes 11 7.71e-01 -5.06e-02 9.03e-01
Pre-NOTCH Transcription and Translation 47 5.49e-01 5.06e-02 7.73e-01
Termination of translesion DNA synthesis 32 6.23e-01 -5.03e-02 8.16e-01
GRB2 events in ERBB2 signaling 11 7.74e-01 5.00e-02 9.04e-01
Dual Incision in GG-NER 41 5.81e-01 4.99e-02 7.91e-01
MyD88 cascade initiated on plasma membrane 95 4.02e-01 4.98e-02 6.74e-01
Toll Like Receptor 10 (TLR10) Cascade 95 4.02e-01 4.98e-02 6.74e-01
Toll Like Receptor 5 (TLR5) Cascade 95 4.02e-01 4.98e-02 6.74e-01
Lysine catabolism 11 7.76e-01 4.96e-02 9.04e-01
Anti-inflammatory response favouring Leishmania parasite infection 133 3.23e-01 4.96e-02 6.14e-01
Leishmania parasite growth and survival 133 3.23e-01 4.96e-02 6.14e-01
COPI-mediated anterograde transport 92 4.14e-01 4.93e-02 6.85e-01
Chromosome Maintenance 103 3.89e-01 -4.91e-02 6.67e-01
Collagen biosynthesis and modifying enzymes 46 5.65e-01 4.91e-02 7.83e-01
ZBP1(DAI) mediated induction of type I IFNs 20 7.04e-01 -4.91e-02 8.70e-01
VxPx cargo-targeting to cilium 19 7.12e-01 -4.89e-02 8.72e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 6.13e-01 -4.87e-02 8.13e-01
Formation of the nephric duct 8 8.13e-01 -4.82e-02 9.19e-01
Signaling by GPCR 446 8.15e-02 4.81e-02 2.79e-01
GPCR downstream signalling 399 9.90e-02 4.81e-02 3.09e-01
RHO GTPases Activate Formins 128 3.47e-01 -4.81e-02 6.36e-01
VEGFR2 mediated cell proliferation 18 7.24e-01 4.80e-02 8.79e-01
Signaling by Retinoic Acid 29 6.58e-01 4.74e-02 8.42e-01
Diseases of mitotic cell cycle 38 6.15e-01 -4.71e-02 8.13e-01
Signaling by EGFR in Cancer 22 7.04e-01 -4.67e-02 8.70e-01
Dual incision in TC-NER 63 5.21e-01 4.67e-02 7.61e-01
Glucagon-type ligand receptors 20 7.18e-01 -4.66e-02 8.75e-01
TGF-beta receptor signaling activates SMADs 45 5.89e-01 4.65e-02 7.98e-01
Metabolism of lipids 641 4.47e-02 4.65e-02 1.84e-01
Nonhomologous End-Joining (NHEJ) 40 6.15e-01 -4.60e-02 8.13e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 7.78e-01 4.52e-02 9.05e-01
HCMV Early Events 84 4.77e-01 -4.49e-02 7.29e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 7.65e-01 4.45e-02 9.02e-01
Intra-Golgi traffic 43 6.14e-01 -4.44e-02 8.13e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 7.74e-01 -4.42e-02 9.04e-01
RNA Polymerase II Pre-transcription Events 77 5.04e-01 -4.41e-02 7.45e-01
SHC1 events in ERBB2 signaling 17 7.53e-01 4.41e-02 8.93e-01
TP53 Regulates Transcription of DNA Repair Genes 61 5.52e-01 -4.40e-02 7.76e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 4.87e-01 4.39e-02 7.33e-01
Kinesins 51 5.90e-01 4.36e-02 7.98e-01
Diseases of branched-chain amino acid catabolism 13 7.86e-01 4.36e-02 9.09e-01
Scavenging by Class A Receptors 12 7.94e-01 4.35e-02 9.14e-01
FCERI mediated MAPK activation 94 4.67e-01 4.34e-02 7.20e-01
M Phase 346 1.70e-01 -4.30e-02 4.34e-01
Pyruvate metabolism 44 6.24e-01 4.28e-02 8.16e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.99e-01 4.27e-02 7.40e-01
Lysosphingolipid and LPA receptors 11 8.07e-01 4.25e-02 9.18e-01
Neurotransmitter receptors and postsynaptic signal transmission 139 3.87e-01 4.25e-02 6.67e-01
Ion homeostasis 42 6.34e-01 4.25e-02 8.23e-01
FCGR3A-mediated phagocytosis 122 4.18e-01 4.24e-02 6.85e-01
Leishmania phagocytosis 122 4.18e-01 4.24e-02 6.85e-01
Parasite infection 122 4.18e-01 4.24e-02 6.85e-01
Glycolysis 68 5.46e-01 -4.24e-02 7.73e-01
EPHB-mediated forward signaling 40 6.43e-01 4.23e-02 8.30e-01
Signaling by FLT3 ITD and TKD mutants 15 7.77e-01 -4.22e-02 9.05e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 8.00e-01 -4.22e-02 9.15e-01
Receptor Mediated Mitophagy 11 8.09e-01 4.21e-02 9.18e-01
IRF3-mediated induction of type I IFN 12 8.01e-01 -4.20e-02 9.16e-01
Reproduction 86 5.05e-01 -4.16e-02 7.46e-01
FCGR activation 77 5.32e-01 4.12e-02 7.65e-01
Formation of xylulose-5-phosphate 5 8.73e-01 -4.12e-02 9.50e-01
Cell Cycle Checkpoints 246 2.71e-01 -4.07e-02 5.56e-01
Synthesis of PG 8 8.42e-01 -4.06e-02 9.35e-01
Regulation of KIT signaling 15 7.86e-01 -4.05e-02 9.09e-01
Costimulation by the CD28 family 74 5.48e-01 -4.04e-02 7.73e-01
RAC2 GTPase cycle 85 5.20e-01 4.03e-02 7.61e-01
WNT ligand biogenesis and trafficking 20 7.56e-01 4.01e-02 8.94e-01
Meiotic recombination 37 6.74e-01 4.00e-02 8.54e-01
SMAC (DIABLO) binds to IAPs 7 8.55e-01 4.00e-02 9.39e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 8.55e-01 4.00e-02 9.39e-01
SMAC, XIAP-regulated apoptotic response 7 8.55e-01 4.00e-02 9.39e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 6.82e-01 4.00e-02 8.58e-01
Neddylation 216 3.12e-01 3.99e-02 6.02e-01
Signaling by NOTCH2 33 6.95e-01 3.94e-02 8.66e-01
PLC beta mediated events 40 6.67e-01 3.93e-02 8.47e-01
Cellular Senescence 143 4.18e-01 3.92e-02 6.85e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 7.29e-01 3.92e-02 8.81e-01
Protein-protein interactions at synapses 58 6.06e-01 -3.92e-02 8.10e-01
Membrane binding and targetting of GAG proteins 13 8.08e-01 -3.90e-02 9.18e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 8.08e-01 -3.90e-02 9.18e-01
Glycine degradation 7 8.61e-01 3.83e-02 9.42e-01
Glucose metabolism 76 5.65e-01 -3.82e-02 7.83e-01
Diseases of glycosylation 110 4.92e-01 3.79e-02 7.34e-01
Signaling by NTRK3 (TRKC) 15 7.99e-01 -3.79e-02 9.15e-01
Synthesis of PC 23 7.54e-01 3.77e-02 8.93e-01
TGFBR3 PTM regulation 10 8.37e-01 3.77e-02 9.33e-01
Synthesis of bile acids and bile salts 26 7.42e-01 3.73e-02 8.87e-01
CHL1 interactions 8 8.55e-01 -3.72e-02 9.39e-01
Base Excision Repair 57 6.28e-01 -3.71e-02 8.18e-01
Cardiac conduction 89 5.46e-01 3.70e-02 7.73e-01
Activation of NOXA and translocation to mitochondria 5 8.87e-01 -3.69e-02 9.55e-01
Signaling by WNT 240 3.26e-01 3.68e-02 6.16e-01
Activation of NMDA receptors and postsynaptic events 74 5.85e-01 3.67e-02 7.95e-01
Transcriptional regulation by small RNAs 61 6.24e-01 -3.63e-02 8.16e-01
Golgi-to-ER retrograde transport 123 4.87e-01 3.63e-02 7.33e-01
Bile acid and bile salt metabolism 30 7.32e-01 3.62e-02 8.82e-01
Regulation of NF-kappa B signaling 18 7.91e-01 3.61e-02 9.13e-01
Aspirin ADME 15 8.09e-01 -3.60e-02 9.18e-01
XBP1(S) activates chaperone genes 44 6.81e-01 -3.58e-02 8.58e-01
Death Receptor Signaling 145 4.58e-01 -3.57e-02 7.17e-01
TNFR1-induced NF-kappa-B signaling pathway 32 7.27e-01 3.56e-02 8.81e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 7.49e-01 3.56e-02 8.91e-01
Translesion synthesis by POLK 17 8.00e-01 -3.54e-02 9.15e-01
Phase 2 - plateau phase 11 8.39e-01 3.54e-02 9.34e-01
Protein lipoylation 10 8.47e-01 -3.52e-02 9.38e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 8.02e-01 -3.51e-02 9.16e-01
SARS-CoV-2-host interactions 182 4.17e-01 -3.49e-02 6.85e-01
Toll Like Receptor 3 (TLR3) Cascade 104 5.41e-01 3.47e-02 7.70e-01
SARS-CoV-1 Infection 137 4.94e-01 3.38e-02 7.37e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 8.27e-01 -3.38e-02 9.28e-01
FGFR2 mutant receptor activation 23 7.81e-01 3.35e-02 9.07e-01
Neuronal System 270 3.45e-01 3.34e-02 6.35e-01
Cargo concentration in the ER 31 7.48e-01 3.34e-02 8.90e-01
Signaling by ERBB2 TMD/JMD mutants 17 8.12e-01 -3.33e-02 9.19e-01
Recognition of DNA damage by PCNA-containing replication complex 30 7.52e-01 3.33e-02 8.93e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 6.16e-01 3.32e-02 8.13e-01
Asparagine N-linked glycosylation 286 3.34e-01 3.32e-02 6.23e-01
G beta:gamma signalling through BTK 15 8.24e-01 -3.31e-02 9.27e-01
SHC1 events in ERBB4 signaling 10 8.57e-01 -3.30e-02 9.39e-01
p75NTR negatively regulates cell cycle via SC1 5 8.99e-01 -3.29e-02 9.62e-01
Metabolism of RNA 717 1.35e-01 -3.27e-02 3.74e-01
Apoptotic cleavage of cell adhesion proteins 8 8.73e-01 3.26e-02 9.50e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 5.74e-01 3.25e-02 7.89e-01
RHOD GTPase cycle 49 6.94e-01 -3.25e-02 8.66e-01
Signaling by FGFR3 32 7.51e-01 -3.25e-02 8.92e-01
RNA Polymerase I Transcription Termination 30 7.60e-01 3.22e-02 8.97e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 6.75e-01 -3.21e-02 8.54e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 8.26e-01 3.17e-02 9.28e-01
Neurotransmitter release cycle 35 7.46e-01 -3.16e-02 8.90e-01
HIV Transcription Initiation 45 7.14e-01 3.16e-02 8.72e-01
RNA Polymerase II HIV Promoter Escape 45 7.14e-01 3.16e-02 8.72e-01
RNA Polymerase II Promoter Escape 45 7.14e-01 3.16e-02 8.72e-01
RNA Polymerase II Transcription Initiation 45 7.14e-01 3.16e-02 8.72e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 7.14e-01 3.16e-02 8.72e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 7.14e-01 3.16e-02 8.72e-01
Drug ADME 57 6.81e-01 3.15e-02 8.58e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.64e-01 3.13e-02 9.43e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 6.09e-01 3.12e-02 8.12e-01
Voltage gated Potassium channels 27 7.79e-01 3.12e-02 9.06e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 8.25e-01 -3.10e-02 9.27e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 8.25e-01 -3.10e-02 9.27e-01
G-protein activation 19 8.15e-01 -3.10e-02 9.21e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 7.84e-01 3.04e-02 9.09e-01
Translation of Structural Proteins 9694635 56 6.95e-01 3.03e-02 8.66e-01
Regulation of actin dynamics for phagocytic cup formation 124 5.61e-01 3.02e-02 7.82e-01
RNA Polymerase III Transcription Initiation 36 7.55e-01 -3.01e-02 8.93e-01
Translesion synthesis by POLI 17 8.30e-01 3.00e-02 9.30e-01
N-Glycan antennae elongation 13 8.52e-01 2.99e-02 9.39e-01
Transmission across Chemical Synapses 183 4.91e-01 2.95e-02 7.34e-01
Signaling by Nuclear Receptors 210 4.62e-01 -2.94e-02 7.17e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 8.54e-01 2.94e-02 9.39e-01
FCGR3A-mediated IL10 synthesis 100 6.12e-01 2.94e-02 8.13e-01
Signaling by ERBB2 44 7.36e-01 2.93e-02 8.84e-01
Metabolism of vitamins and cofactors 167 5.14e-01 2.93e-02 7.55e-01
RUNX3 regulates WNT signaling 8 8.87e-01 2.90e-02 9.55e-01
Regulation of TP53 Activity through Methylation 19 8.27e-01 -2.89e-02 9.28e-01
RHO GTPases activate KTN1 11 8.70e-01 -2.85e-02 9.48e-01
Amine ligand-binding receptors 10 8.76e-01 -2.85e-02 9.52e-01
Sensory processing of sound by outer hair cells of the cochlea 41 7.53e-01 2.84e-02 8.93e-01
FOXO-mediated transcription of cell cycle genes 14 8.54e-01 2.83e-02 9.39e-01
Synthesis of PA 31 7.86e-01 2.81e-02 9.09e-01
MHC class II antigen presentation 113 6.08e-01 2.80e-02 8.11e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 8.22e-01 -2.77e-02 9.26e-01
Ub-specific processing proteases 153 5.56e-01 2.76e-02 7.79e-01
SUMOylation of transcription factors 16 8.51e-01 -2.71e-02 9.39e-01
Activation of caspases through apoptosome-mediated cleavage 6 9.09e-01 -2.70e-02 9.64e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 8.47e-01 -2.70e-02 9.38e-01
RHOC GTPase cycle 71 6.94e-01 -2.70e-02 8.66e-01
Fertilization 13 8.66e-01 2.70e-02 9.45e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.02e-01 -2.68e-02 9.63e-01
IRE1alpha activates chaperones 46 7.54e-01 -2.67e-02 8.93e-01
O-linked glycosylation 85 6.72e-01 2.66e-02 8.53e-01
P2Y receptors 10 8.84e-01 -2.66e-02 9.54e-01
FOXO-mediated transcription 58 7.28e-01 2.64e-02 8.81e-01
Acetylcholine regulates insulin secretion 9 8.91e-01 -2.63e-02 9.58e-01
RHO GTPases activate CIT 18 8.47e-01 2.63e-02 9.38e-01
RHOA GTPase cycle 138 5.95e-01 -2.62e-02 8.01e-01
Metabolism of amine-derived hormones 10 8.87e-01 2.61e-02 9.55e-01
Diseases associated with O-glycosylation of proteins 50 7.50e-01 -2.61e-02 8.91e-01
Infectious disease 958 1.73e-01 2.60e-02 4.38e-01
IKK complex recruitment mediated by RIP1 23 8.31e-01 2.58e-02 9.30e-01
Apoptotic cleavage of cellular proteins 35 7.92e-01 -2.57e-02 9.13e-01
RHOU GTPase cycle 40 7.79e-01 2.56e-02 9.06e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 6.35e-01 -2.54e-02 8.23e-01
RUNX3 regulates CDKN1A transcription 7 9.08e-01 2.53e-02 9.64e-01
O-glycosylation of TSR domain-containing proteins 28 8.18e-01 2.51e-02 9.23e-01
G alpha (s) signalling events 96 6.73e-01 2.49e-02 8.54e-01
rRNA modification in the mitochondrion 8 9.04e-01 2.47e-02 9.63e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 8.57e-01 2.46e-02 9.39e-01
Activation of the phototransduction cascade 9 8.99e-01 -2.46e-02 9.62e-01
RIPK1-mediated regulated necrosis 31 8.13e-01 2.45e-02 9.19e-01
Regulation of necroptotic cell death 31 8.13e-01 2.45e-02 9.19e-01
Cytosolic tRNA aminoacylation 24 8.35e-01 2.45e-02 9.33e-01
Signaling by Non-Receptor Tyrosine Kinases 47 7.72e-01 -2.45e-02 9.03e-01
Signaling by PTK6 47 7.72e-01 -2.45e-02 9.03e-01
G2/M Checkpoints 126 6.37e-01 2.43e-02 8.25e-01
eNOS activation 11 8.91e-01 -2.40e-02 9.58e-01
SLC-mediated transmembrane transport 174 5.86e-01 2.40e-02 7.95e-01
COPII-mediated vesicle transport 67 7.37e-01 -2.37e-02 8.84e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 8.28e-01 2.37e-02 9.29e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 9.27e-01 2.36e-02 9.73e-01
Cytosolic sensors of pathogen-associated DNA 63 7.46e-01 -2.36e-02 8.90e-01
TNFR1-induced proapoptotic signaling 24 8.42e-01 -2.35e-02 9.35e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 8.80e-01 2.33e-02 9.52e-01
Interleukin-6 family signaling 20 8.57e-01 2.33e-02 9.39e-01
Regulated Necrosis 56 7.67e-01 2.29e-02 9.02e-01
HIV Infection 213 5.65e-01 -2.29e-02 7.83e-01
TNF signaling 56 7.70e-01 2.26e-02 9.03e-01
tRNA Aminoacylation 42 8.00e-01 -2.25e-02 9.15e-01
HDACs deacetylate histones 45 7.94e-01 -2.25e-02 9.14e-01
MyD88 dependent cascade initiated on endosome 101 6.96e-01 2.25e-02 8.66e-01
Signaling by EGFR 47 7.92e-01 2.22e-02 9.13e-01
CDC42 GTPase cycle 140 6.51e-01 -2.22e-02 8.35e-01
RAC1 GTPase cycle 172 6.18e-01 -2.20e-02 8.13e-01
Separation of Sister Chromatids 168 6.23e-01 2.20e-02 8.16e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 8.83e-01 -2.19e-02 9.54e-01
Glycosphingolipid transport 7 9.21e-01 2.16e-02 9.71e-01
HDL assembly 6 9.27e-01 2.16e-02 9.73e-01
MyD88-independent TLR4 cascade 108 6.98e-01 2.16e-02 8.67e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 6.98e-01 2.16e-02 8.67e-01
DNA Damage/Telomere Stress Induced Senescence 42 8.09e-01 -2.16e-02 9.18e-01
G alpha (q) signalling events 139 6.62e-01 2.15e-02 8.44e-01
Cell-Cell communication 110 6.99e-01 -2.13e-02 8.67e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 7.07e-01 2.13e-02 8.71e-01
Pre-NOTCH Expression and Processing 63 7.72e-01 2.11e-02 9.03e-01
Pyroptosis 25 8.57e-01 2.09e-02 9.39e-01
Defective B3GALTL causes PpS 27 8.52e-01 2.08e-02 9.39e-01
Sodium/Proton exchangers 7 9.24e-01 -2.08e-02 9.73e-01
RHOF GTPase cycle 38 8.25e-01 2.07e-02 9.27e-01
Signaling by PDGF 48 8.06e-01 -2.05e-02 9.18e-01
PECAM1 interactions 12 9.02e-01 -2.05e-02 9.63e-01
HATs acetylate histones 92 7.34e-01 -2.05e-02 8.84e-01
Nucleotide Excision Repair 108 7.16e-01 2.02e-02 8.73e-01
Termination of O-glycan biosynthesis 16 8.91e-01 -1.98e-02 9.58e-01
Acyl chain remodelling of PC 19 8.81e-01 1.98e-02 9.52e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 9.06e-01 -1.97e-02 9.64e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 8.80e-01 -1.96e-02 9.52e-01
Signal Transduction 2051 1.47e-01 1.94e-02 3.94e-01
RMTs methylate histone arginines 35 8.42e-01 -1.94e-02 9.35e-01
Role of ABL in ROBO-SLIT signaling 6 9.34e-01 -1.94e-02 9.74e-01
SHC1 events in EGFR signaling 11 9.12e-01 -1.94e-02 9.64e-01
Signaling by FGFR4 32 8.50e-01 -1.93e-02 9.39e-01
Endosomal/Vacuolar pathway 12 9.10e-01 -1.88e-02 9.64e-01
Extra-nuclear estrogen signaling 65 7.94e-01 1.87e-02 9.14e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 7.99e-01 1.87e-02 9.15e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 7.86e-01 1.82e-02 9.09e-01
Effects of PIP2 hydrolysis 24 8.79e-01 -1.80e-02 9.52e-01
Calcitonin-like ligand receptors 5 9.45e-01 1.78e-02 9.82e-01
Protein ubiquitination 71 7.96e-01 1.77e-02 9.14e-01
MAPK1 (ERK2) activation 9 9.27e-01 -1.76e-02 9.73e-01
Ion transport by P-type ATPases 44 8.40e-01 -1.76e-02 9.34e-01
Aflatoxin activation and detoxification 14 9.11e-01 1.73e-02 9.64e-01
FLT3 Signaling 38 8.54e-01 1.73e-02 9.39e-01
SARS-CoV Infections 434 5.39e-01 -1.72e-02 7.70e-01
Vitamin B1 (thiamin) metabolism 5 9.47e-01 1.70e-02 9.83e-01
Meiotic synapsis 43 8.48e-01 1.69e-02 9.38e-01
MASTL Facilitates Mitotic Progression 10 9.27e-01 1.68e-02 9.73e-01
Toll Like Receptor 9 (TLR9) Cascade 108 7.64e-01 -1.67e-02 9.01e-01
S Phase 150 7.24e-01 1.67e-02 8.79e-01
Uptake and actions of bacterial toxins 27 8.81e-01 1.67e-02 9.52e-01
Mitochondrial biogenesis 91 7.84e-01 -1.66e-02 9.09e-01
Calcineurin activates NFAT 9 9.32e-01 -1.65e-02 9.73e-01
GRB2 events in EGFR signaling 10 9.28e-01 -1.65e-02 9.73e-01
Nucleotide-like (purinergic) receptors 14 9.15e-01 1.64e-02 9.67e-01
G beta:gamma signalling through PLC beta 17 9.08e-01 1.63e-02 9.64e-01
Presynaptic function of Kainate receptors 17 9.08e-01 1.63e-02 9.64e-01
GPVI-mediated activation cascade 32 8.76e-01 1.59e-02 9.52e-01
Role of phospholipids in phagocytosis 89 7.95e-01 -1.59e-02 9.14e-01
Synthesis of substrates in N-glycan biosythesis 59 8.34e-01 1.57e-02 9.32e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 9.51e-01 -1.57e-02 9.83e-01
Maple Syrup Urine Disease 5 9.51e-01 -1.57e-02 9.83e-01
Class I MHC mediated antigen processing & presentation 345 6.17e-01 1.57e-02 8.13e-01
Adaptive Immune System 771 4.62e-01 1.56e-02 7.17e-01
Translesion synthesis by REV1 16 9.14e-01 -1.55e-02 9.66e-01
DARPP-32 events 22 9.00e-01 1.55e-02 9.62e-01
RHOB GTPase cycle 64 8.32e-01 -1.54e-02 9.30e-01
Estrogen-dependent gene expression 96 7.95e-01 1.53e-02 9.14e-01
Metabolism of steroids 123 7.70e-01 1.53e-02 9.03e-01
Synthesis of IP3 and IP4 in the cytosol 22 9.01e-01 -1.53e-02 9.63e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 8.85e-01 -1.53e-02 9.54e-01
SHC-mediated cascade:FGFR1 13 9.24e-01 1.52e-02 9.73e-01
Signaling by NOTCH1 66 8.31e-01 -1.52e-02 9.30e-01
Unfolded Protein Response (UPR) 85 8.09e-01 1.52e-02 9.18e-01
Cell junction organization 78 8.19e-01 -1.50e-02 9.23e-01
Estrogen-stimulated signaling through PRKCZ 6 9.49e-01 1.50e-02 9.83e-01
Sperm Motility And Taxes 6 9.50e-01 1.48e-02 9.83e-01
Regulation of TP53 Degradation 35 8.81e-01 -1.46e-02 9.52e-01
Transcription of the HIV genome 67 8.37e-01 -1.46e-02 9.33e-01
Potential therapeutics for SARS 150 7.59e-01 -1.45e-02 8.97e-01
CLEC7A/inflammasome pathway 6 9.51e-01 -1.45e-02 9.83e-01
Olfactory Signaling Pathway 57 8.50e-01 1.44e-02 9.39e-01
Purine ribonucleoside monophosphate biosynthesis 9 9.41e-01 1.43e-02 9.79e-01
Positive epigenetic regulation of rRNA expression 60 8.49e-01 1.43e-02 9.38e-01
Glucuronidation 8 9.45e-01 1.41e-02 9.82e-01
ER to Golgi Anterograde Transport 145 7.74e-01 1.38e-02 9.04e-01
Insulin receptor signalling cascade 40 8.81e-01 -1.36e-02 9.52e-01
RNA Polymerase III Abortive And Retractive Initiation 40 8.82e-01 -1.36e-02 9.52e-01
RNA Polymerase III Transcription 40 8.82e-01 -1.36e-02 9.52e-01
Viral Infection Pathways 775 5.21e-01 1.36e-02 7.61e-01
Golgi Associated Vesicle Biogenesis 55 8.63e-01 -1.35e-02 9.43e-01
DAG and IP3 signaling 34 8.92e-01 -1.34e-02 9.58e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 9.59e-01 -1.34e-02 9.85e-01
Phospholipid metabolism 183 7.57e-01 1.33e-02 8.94e-01
Unwinding of DNA 12 9.38e-01 1.31e-02 9.77e-01
Vesicle-mediated transport 665 5.66e-01 1.31e-02 7.83e-01
Regulation of PTEN gene transcription 59 8.64e-01 1.29e-02 9.43e-01
CaM pathway 28 9.06e-01 1.29e-02 9.64e-01
Calmodulin induced events 28 9.06e-01 1.29e-02 9.64e-01
Regulation of TP53 Expression and Degradation 36 8.94e-01 1.28e-02 9.59e-01
Transcriptional Regulation by TP53 346 6.84e-01 -1.27e-02 8.59e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.23e-01 1.25e-02 9.73e-01
AKT phosphorylates targets in the nucleus 10 9.46e-01 -1.24e-02 9.82e-01
Ketone body metabolism 8 9.52e-01 1.24e-02 9.83e-01
SARS-CoV-2 Infection 267 7.30e-01 -1.23e-02 8.81e-01
Class B/2 (Secretin family receptors) 57 8.75e-01 -1.21e-02 9.51e-01
ESR-mediated signaling 157 7.96e-01 1.20e-02 9.14e-01
ADP signalling through P2Y purinoceptor 12 18 9.30e-01 -1.19e-02 9.73e-01
RHO GTPase cycle 411 6.80e-01 -1.19e-02 8.58e-01
Transport to the Golgi and subsequent modification 171 7.91e-01 1.18e-02 9.13e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 9.05e-01 -1.15e-02 9.64e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.55e-01 1.15e-02 9.85e-01
Cytochrome P450 - arranged by substrate type 39 9.04e-01 1.12e-02 9.63e-01
CD28 co-stimulation 33 9.11e-01 -1.12e-02 9.64e-01
Diseases of Base Excision Repair 5 9.66e-01 1.12e-02 9.88e-01
Gamma-carboxylation of protein precursors 6 9.63e-01 -1.11e-02 9.87e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.32e-01 1.11e-02 9.73e-01
Phosphorylation of the APC/C 20 9.32e-01 -1.09e-02 9.73e-01
Mitochondrial tRNA aminoacylation 21 9.31e-01 -1.09e-02 9.73e-01
HCMV Late Events 67 8.79e-01 -1.08e-02 9.52e-01
Signaling by ERBB4 45 9.01e-01 1.07e-02 9.63e-01
HCMV Infection 106 8.49e-01 -1.07e-02 9.38e-01
Host Interactions of HIV factors 118 8.41e-01 -1.07e-02 9.35e-01
p75 NTR receptor-mediated signalling 89 8.64e-01 -1.05e-02 9.43e-01
Thromboxane signalling through TP receptor 20 9.38e-01 1.01e-02 9.77e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 9.66e-01 -1.00e-02 9.88e-01
FCERI mediated Ca+2 mobilization 93 8.70e-01 9.84e-03 9.48e-01
PI3K events in ERBB2 signaling 11 9.55e-01 -9.72e-03 9.85e-01
Apoptotic execution phase 46 9.10e-01 9.68e-03 9.64e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 623 6.86e-01 9.48e-03 8.61e-01
Metabolism of water-soluble vitamins and cofactors 116 8.60e-01 -9.45e-03 9.42e-01
Disease 1623 5.29e-01 9.37e-03 7.62e-01
Toll-like Receptor Cascades 162 8.44e-01 8.97e-03 9.36e-01
Signaling by Hippo 18 9.50e-01 8.48e-03 9.83e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 9.53e-01 8.11e-03 9.83e-01
Metal ion SLC transporters 19 9.52e-01 8.03e-03 9.83e-01
Prolactin receptor signaling 11 9.65e-01 -7.73e-03 9.88e-01
RHOG GTPase cycle 70 9.13e-01 -7.58e-03 9.65e-01
Kidney development 17 9.60e-01 7.07e-03 9.85e-01
Formation of RNA Pol II elongation complex 56 9.28e-01 -6.97e-03 9.73e-01
RNA Polymerase II Transcription Elongation 56 9.28e-01 -6.97e-03 9.73e-01
Regulation of CDH19 Expression and Function 6 9.76e-01 -6.95e-03 9.94e-01
Sensory Perception 194 8.70e-01 -6.79e-03 9.48e-01
Factors involved in megakaryocyte development and platelet production 129 8.99e-01 6.44e-03 9.62e-01
Fcgamma receptor (FCGR) dependent phagocytosis 148 8.93e-01 6.42e-03 9.58e-01
Transcriptional regulation of pluripotent stem cells 19 9.61e-01 -6.41e-03 9.86e-01
Regulation of insulin secretion 63 9.30e-01 6.37e-03 9.73e-01
RET signaling 32 9.51e-01 6.21e-03 9.83e-01
RAB GEFs exchange GTP for GDP on RABs 88 9.21e-01 6.15e-03 9.71e-01
Diseases of signal transduction by growth factor receptors and second messengers 401 8.34e-01 -6.09e-03 9.32e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 9.60e-01 -5.97e-03 9.85e-01
Telomere Maintenance 78 9.27e-01 -5.97e-03 9.73e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 9.60e-01 -5.86e-03 9.85e-01
Glycosphingolipid biosynthesis 15 9.69e-01 5.82e-03 9.90e-01
Mitotic G2-G2/M phases 179 8.97e-01 5.59e-03 9.62e-01
Processing of Capped Intronless Pre-mRNA 29 9.60e-01 5.43e-03 9.85e-01
Mitotic Metaphase and Anaphase 212 8.92e-01 -5.43e-03 9.58e-01
MAPK3 (ERK1) activation 10 9.76e-01 -5.43e-03 9.94e-01
Cytokine Signaling in Immune system 668 8.11e-01 -5.42e-03 9.19e-01
Defects in biotin (Btn) metabolism 8 9.79e-01 5.29e-03 9.94e-01
Specification of primordial germ cells 6 9.83e-01 5.06e-03 9.94e-01
Signaling by Rho GTPases 607 8.37e-01 4.88e-03 9.33e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.69e-01 4.84e-03 9.90e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.69e-01 4.84e-03 9.90e-01
Rap1 signalling 14 9.75e-01 4.78e-03 9.94e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 9.83e-01 4.59e-03 9.94e-01
G-protein mediated events 44 9.60e-01 4.40e-03 9.85e-01
Prostacyclin signalling through prostacyclin receptor 16 9.76e-01 4.36e-03 9.94e-01
Downregulation of TGF-beta receptor signaling 26 9.70e-01 4.29e-03 9.90e-01
Disorders of transmembrane transporters 136 9.34e-01 4.12e-03 9.74e-01
TBC/RABGAPs 45 9.63e-01 -3.99e-03 9.87e-01
Attachment of GPI anchor to uPAR 7 9.86e-01 3.97e-03 9.94e-01
NFE2L2 regulating MDR associated enzymes 8 9.85e-01 -3.96e-03 9.94e-01
Rab regulation of trafficking 121 9.41e-01 3.90e-03 9.79e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 9.73e-01 -3.83e-03 9.92e-01
Regulation of FZD by ubiquitination 16 9.80e-01 3.61e-03 9.94e-01
Opioid Signalling 75 9.58e-01 -3.48e-03 9.85e-01
Mitotic Anaphase 211 9.31e-01 -3.45e-03 9.73e-01
SUMOylation of intracellular receptors 26 9.77e-01 3.24e-03 9.94e-01
Diseases associated with glycosaminoglycan metabolism 26 9.77e-01 -3.20e-03 9.94e-01
Maturation of hRSV A proteins 13 9.85e-01 3.09e-03 9.94e-01
Assembly Of The HIV Virion 15 9.84e-01 -3.02e-03 9.94e-01
EPHA-mediated growth cone collapse 21 9.81e-01 -2.97e-03 9.94e-01
PI3K/AKT Signaling in Cancer 84 9.63e-01 -2.90e-03 9.87e-01
Calnexin/calreticulin cycle 26 9.80e-01 2.88e-03 9.94e-01
Uptake and function of anthrax toxins 11 9.87e-01 -2.82e-03 9.94e-01
Nuclear signaling by ERBB4 24 9.82e-01 2.63e-03 9.94e-01
RND3 GTPase cycle 35 9.80e-01 -2.50e-03 9.94e-01
WNT mediated activation of DVL 8 9.90e-01 2.44e-03 9.95e-01
Deubiquitination 225 9.52e-01 2.32e-03 9.83e-01
Endogenous sterols 17 9.87e-01 -2.32e-03 9.94e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 9.58e-01 -2.22e-03 9.85e-01
Membrane Trafficking 574 9.29e-01 2.17e-03 9.73e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 37 9.82e-01 -2.15e-03 9.94e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 9.91e-01 -2.03e-03 9.95e-01
Post-translational protein modification 1245 9.10e-01 -1.91e-03 9.64e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 9.94e-01 -1.89e-03 9.97e-01
FOXO-mediated transcription of cell death genes 16 9.90e-01 1.85e-03 9.95e-01
Diseases associated with the TLR signaling cascade 29 9.86e-01 -1.85e-03 9.94e-01
Diseases of Immune System 29 9.86e-01 -1.85e-03 9.94e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 9.87e-01 -1.65e-03 9.94e-01
Toxicity of botulinum toxin type D (botD) 5 9.96e-01 -1.36e-03 9.98e-01
Toxicity of botulinum toxin type F (botF) 5 9.96e-01 -1.36e-03 9.98e-01
Signaling by LTK 10 9.94e-01 -1.32e-03 9.97e-01
Ovarian tumor domain proteases 37 9.90e-01 -1.18e-03 9.95e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 9.82e-01 -8.10e-04 9.94e-01
Expression and translocation of olfactory receptors 52 9.92e-01 7.92e-04 9.96e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 9.99e-01 4.48e-04 1.00e+00
EPH-ephrin mediated repulsion of cells 43 9.98e-01 -2.57e-04 9.99e-01
Triglyceride biosynthesis 9 9.99e-01 2.29e-04 1.00e+00
G2/M Transition 177 1.00e+00 1.02e-05 1.00e+00


Detailed Gene set reports



Biosynthesis of EPA-derived SPMs
set Biosynthesis of EPA-derived SPMs
setSize 6
pANOVA 0.000257
s.dist 0.861
p.adjustANOVA 0.00439


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 10673
HPGD 10510
PTGS2 10481
ALOX15 9878
LTA4H 8078
GPX4 5551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 10673
HPGD 10510
PTGS2 10481
ALOX15 9878
LTA4H 8078
GPX4 5551


Biosynthesis of Lipoxins (LX)
set Biosynthesis of Lipoxins (LX)
setSize 6
pANOVA 0.000335
s.dist 0.845
p.adjustANOVA 0.00525


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 10673
HPGD 10510
ALOX5AP 9681
PTGR1 8101
ALOX12 8084
LTC4S 7069

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All member genes
GeneID Gene Rank
ALOX5 10673
HPGD 10510
ALOX5AP 9681
PTGR1 8101
ALOX12 8084
LTC4S 7069


Biosynthesis of E-series 18(S)-resolvins
set Biosynthesis of E-series 18(S)-resolvins
setSize 5
pANOVA 0.00117
s.dist 0.838
p.adjustANOVA 0.0135


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 10673
HPGD 10510
ALOX15 9878
LTA4H 8078
GPX4 5551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 10673
HPGD 10510
ALOX15 9878
LTA4H 8078
GPX4 5551


Protein repair
set Protein repair
setSize 6
pANOVA 0.000927
s.dist 0.781
p.adjustANOVA 0.0115


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSRB2 9933
MSRA 9083
PCMT1 8982
MSRB1 8273
TXN 7800
MSRB3 5799

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All member genes
GeneID Gene Rank
MSRB2 9933
MSRA 9083
PCMT1 8982
MSRB1 8273
TXN 7800
MSRB3 5799


Cross-presentation of particulate exogenous antigens (phagosomes)
set Cross-presentation of particulate exogenous antigens (phagosomes)
setSize 8
pANOVA 0.000206
s.dist 0.758
p.adjustANOVA 0.00364


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCF1 10361
NCF4 10214
CD36 9365
ITGB5 8398
ITGAV 7841
CYBB 7002
CYBA 5969
NCF2 5329

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCF1 10361
NCF4 10214
CD36 9365
ITGB5 8398
ITGAV 7841
CYBB 7002
CYBA 5969
NCF2 5329


Synthesis of 15-eicosatetraenoic acid derivatives
set Synthesis of 15-eicosatetraenoic acid derivatives
setSize 6
pANOVA 0.00271
s.dist 0.707
p.adjustANOVA 0.0241


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTGS2 10481
GPX1 10479
ALOX15B 10350
ALOX15 9878
GPX4 5551
GPX2 -1708

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGS2 10481
GPX1 10479
ALOX15B 10350
ALOX15 9878
GPX4 5551
GPX2 -1708


MECP2 regulates transcription of neuronal ligands
set MECP2 regulates transcription of neuronal ligands
setSize 5
pANOVA 0.00706
s.dist -0.696
p.adjustANOVA 0.0525


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10541
CREB1 -9848
MECP2 -9072
DLL1 -6635
HDAC1 -3045

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10541
CREB1 -9848
MECP2 -9072
DLL1 -6635
HDAC1 -3045


Synthesis of 5-eicosatetraenoic acids
set Synthesis of 5-eicosatetraenoic acids
setSize 7
pANOVA 0.00155
s.dist 0.691
p.adjustANOVA 0.0165


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 10673
GPX1 10479
ALOX5AP 9681
PON2 9564
LTC4S 7069
GPX4 5551
GPX2 -1708

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 10673
GPX1 10479
ALOX5AP 9681
PON2 9564
LTC4S 7069
GPX4 5551
GPX2 -1708


Fructose catabolism
set Fructose catabolism
setSize 5
pANOVA 0.0104
s.dist 0.661
p.adjustANOVA 0.0667


Top enriched genes
Top 20 genes
GeneID Gene Rank
GLYCTK 8818
TKFC 8786
ALDH1A1 8573
KHK 5880
ALDOB 2986

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GLYCTK 8818
TKFC 8786
ALDH1A1 8573
KHK 5880
ALDOB 2986


Synthesis of 12-eicosatetraenoic acid derivatives
set Synthesis of 12-eicosatetraenoic acid derivatives
setSize 6
pANOVA 0.00506
s.dist 0.661
p.adjustANOVA 0.04


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX1 10479
ALOX15 9878
ALOX12B 9722
ALOX12 8084
GPX4 5551
GPX2 -1708

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX1 10479
ALOX15 9878
ALOX12B 9722
ALOX12 8084
GPX4 5551
GPX2 -1708


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.00127
s.dist -0.658
p.adjustANOVA 0.0143


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLB -10304
ADPRS -9752
FEN1 -9569
PARP1 -8369
LIG1 -7282
PARP2 -7048
PARG -6241
APEX1 -732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLB -10304
ADPRS -9752
FEN1 -9569
PARP1 -8369
LIG1 -7282
PARP2 -7048
PARG -6241
APEX1 -732


Signal attenuation
set Signal attenuation
setSize 9
pANOVA 0.000686
s.dist 0.653
p.adjustANOVA 0.00906


Top enriched genes
Top 20 genes
GeneID Gene Rank
INSR 10599
IRS1 10590
GRB10 10508
IRS2 10342
MAPK1 8538
MAPK3 8522
SOS1 2160
GRB2 1766
SHC1 -745

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INSR 10599
IRS1 10590
GRB10 10508
IRS2 10342
MAPK1 8538
MAPK3 8522
SOS1 2160
GRB2 1766
SHC1 -745


Interleukin-21 signaling
set Interleukin-21 signaling
setSize 9
pANOVA 0.00118
s.dist -0.624
p.adjustANOVA 0.0136


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAT4 -9744
IL21R -9400
JAK1 -9052
STAT5A -8508
STAT1 -7763
STAT5B -6316
STAT3 -6066
IL2RG -4151
JAK3 -2410

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT4 -9744
IL21R -9400
JAK1 -9052
STAT5A -8508
STAT1 -7763
STAT5B -6316
STAT3 -6066
IL2RG -4151
JAK3 -2410


OAS antiviral response
set OAS antiviral response
setSize 8
pANOVA 0.00258
s.dist -0.615
p.adjustANOVA 0.0232


Top enriched genes
Top 20 genes
GeneID Gene Rank
OAS2 -10997
OAS3 -10941
OASL -10746
OAS1 -9575
PDE12 -6942
RNASEL -4090
ABCE1 -3594
FLNA 1302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OAS2 -10997
OAS3 -10941
OASL -10746
OAS1 -9575
PDE12 -6942
RNASEL -4090
ABCE1 -3594
FLNA 1302


Acetylcholine binding and downstream events
set Acetylcholine binding and downstream events
setSize 5
pANOVA 0.0187
s.dist -0.607
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHRNA2 -9827
CHRNB2 -9590
CHRNE -7894
CHRNA5 -6903
CHRNA7 -83

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHRNA2 -9827
CHRNB2 -9590
CHRNE -7894
CHRNA5 -6903
CHRNA7 -83


Postsynaptic nicotinic acetylcholine receptors
set Postsynaptic nicotinic acetylcholine receptors
setSize 5
pANOVA 0.0187
s.dist -0.607
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHRNA2 -9827
CHRNB2 -9590
CHRNE -7894
CHRNA5 -6903
CHRNA7 -83

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHRNA2 -9827
CHRNB2 -9590
CHRNE -7894
CHRNA5 -6903
CHRNA7 -83


Defective LFNG causes SCDO3
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0268
s.dist -0.572
p.adjustANOVA 0.13


Top enriched genes
Top 20 genes
GeneID Gene Rank
LFNG -8534
NOTCH3 -8266
NOTCH1 -7149
NOTCH2 -5311
NOTCH4 -3113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LFNG -8534
NOTCH3 -8266
NOTCH1 -7149
NOTCH2 -5311
NOTCH4 -3113


Histidine catabolism
set Histidine catabolism
setSize 7
pANOVA 0.0089
s.dist 0.571
p.adjustANOVA 0.061


Top enriched genes
Top 20 genes
GeneID Gene Rank
HDC 9826
HAL 8823
AMDHD1 8795
FTCD 6870
CARNS1 6398
HNMT 3243
CARNMT1 -1826

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HDC 9826
HAL 8823
AMDHD1 8795
FTCD 6870
CARNS1 6398
HNMT 3243
CARNMT1 -1826


NFE2L2 regulating inflammation associated genes
set NFE2L2 regulating inflammation associated genes
setSize 5
pANOVA 0.0272
s.dist -0.57
p.adjustANOVA 0.131


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCL2 -10469
NFE2L2 -10399
EP300 -9611
CREBBP -5188
MAFK 3377

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL2 -10469
NFE2L2 -10399
EP300 -9611
CREBBP -5188
MAFK 3377


Keratan sulfate degradation
set Keratan sulfate degradation
setSize 9
pANOVA 0.00319
s.dist 0.568
p.adjustANOVA 0.0275


Top enriched genes
Top 20 genes
GeneID Gene Rank
HEXA 10545
GALNS 9822
GLB1L 9782
GNS 9767
GLB1L2 8725
GLB1 7230
HEXB 5898
PRELP -3072
GLB1L3 -4865

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HEXA 10545
GALNS 9822
GLB1L 9782
GNS 9767
GLB1L2 8725
GLB1 7230
HEXB 5898
PRELP -3072
GLB1L3 -4865


Formyl peptide receptors bind formyl peptides and many other ligands
set Formyl peptide receptors bind formyl peptides and many other ligands
setSize 7
pANOVA 0.0102
s.dist 0.561
p.adjustANOVA 0.0658


Top enriched genes
Top 20 genes
GeneID Gene Rank
APP 9659
FPR1 9487
ANXA1 8782
FPR2 7029
HEBP1 6916
MT-RNR2 4179
FPR3 -4713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APP 9659
FPR1 9487
ANXA1 8782
FPR2 7029
HEBP1 6916
MT-RNR2 4179
FPR3 -4713


Antimicrobial peptides
set Antimicrobial peptides
setSize 34
pANOVA 1.86e-08
s.dist 0.557
p.adjustANOVA 1.43e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
S100A9 10671
S100A8 10617
TLR2 10546
PRTN3 10442
DEFA4 10436
PDZD11 10384
BPI 10328
LCN2 10319
DEFA1 10309
PGLYRP1 10287
ELANE 10155
DEFA3 10130
LTF 10051
CAMP 10047
CTSG 9989
RNASE3 9781
ATOX1 9629
CLU 9184
PGLYRP2 8901
PI3 8454

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 10671
S100A8 10617
TLR2 10546
PRTN3 10442
DEFA4 10436
PDZD11 10384
BPI 10328
LCN2 10319
DEFA1 10309
PGLYRP1 10287
ELANE 10155
DEFA3 10130
LTF 10051
CAMP 10047
CTSG 9989
RNASE3 9781
ATOX1 9629
CLU 9184
PGLYRP2 8901
PI3 8454
SLC11A1 7180
PGLYRP3 7009
RNASE6 5828
HTN1 4554
GNLY 3144
EPPIN 1389
LYZ 1376
CCR2 564
CCR6 -2194
TLR1 -3973
ITLN1 -4862
CD4 -5152
ATP7A -8015
LEAP2 -8236


Loss of MECP2 binding ability to the NCoR/SMRT complex
set Loss of MECP2 binding ability to the NCoR/SMRT complex
setSize 7
pANOVA 0.0107
s.dist -0.557
p.adjustANOVA 0.0678


Top enriched genes
Top 20 genes
GeneID Gene Rank
TBL1XR1 -9204
MECP2 -9072
NCOR1 -8299
GPS2 -5867
HDAC3 -5574
TBL1X -4524
NCOR2 -1626

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TBL1XR1 -9204
MECP2 -9072
NCOR1 -8299
GPS2 -5867
HDAC3 -5574
TBL1X -4524
NCOR2 -1626


Replacement of protamines by nucleosomes in the male pronucleus
set Replacement of protamines by nucleosomes in the male pronucleus
setSize 13
pANOVA 0.000531
s.dist 0.555
p.adjustANOVA 0.00747


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC12 10667
NPM2 10648
H2BC11 10012
H2BC9 9583
METTL23 9421
H2BC5 8893
H2BC21 8889
H2BC17 7380
H3-3A 5381
H2BC15 4623
SRPK1 -901
H2BC4 -1116
HIRA -7537

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC12 10667
NPM2 10648
H2BC11 10012
H2BC9 9583
METTL23 9421
H2BC5 8893
H2BC21 8889
H2BC17 7380
H3-3A 5381
H2BC15 4623
SRPK1 -901
H2BC4 -1116
HIRA -7537


Diseases of Mismatch Repair (MMR)
set Diseases of Mismatch Repair (MMR)
setSize 5
pANOVA 0.0323
s.dist -0.553
p.adjustANOVA 0.149


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH6 -9048
MLH1 -8366
PMS2 -7603
MSH2 -7264
MSH3 951

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH6 -9048
MLH1 -8366
PMS2 -7603
MSH2 -7264
MSH3 951


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0335
s.dist 0.549
p.adjustANOVA 0.152


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 9336
ETHE1 8853
TST 8547
SUOX 5599
TSTD1 -3438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 9336
ETHE1 8853
TST 8547
SUOX 5599
TSTD1 -3438


Cohesin Loading onto Chromatin
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 0.00267
s.dist -0.548
p.adjustANOVA 0.0239


Top enriched genes
Top 20 genes
GeneID Gene Rank
NIPBL -10706
STAG1 -9862
STAG2 -9389
SMC3 -9273
SMC1A -7182
RAD21 -5905
PDS5B -4562
WAPL -4275
MAU2 -2908
PDS5A 1898

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NIPBL -10706
STAG1 -9862
STAG2 -9389
SMC3 -9273
SMC1A -7182
RAD21 -5905
PDS5B -4562
WAPL -4275
MAU2 -2908
PDS5A 1898


RNA Polymerase I Promoter Opening
set RNA Polymerase I Promoter Opening
setSize 17
pANOVA 9.26e-05
s.dist 0.548
p.adjustANOVA 0.0023


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC12 10667.0
H3C15 10034.5
H2BC11 10012.0
H2BC9 9583.0
H2BC5 8893.0
H2BC21 8889.0
MBD2 8617.0
MAPK3 8522.0
H2AC6 7406.0
H2BC17 7380.0
H2AJ 6444.0
H3-3A 5381.0
H2BC15 4623.0
H2AC20 1385.0
H2BC4 -1116.0
H2AZ2 -2370.0
UBTF -6426.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC12 10667.0
H3C15 10034.5
H2BC11 10012.0
H2BC9 9583.0
H2BC5 8893.0
H2BC21 8889.0
MBD2 8617.0
MAPK3 8522.0
H2AC6 7406.0
H2BC17 7380.0
H2AJ 6444.0
H3-3A 5381.0
H2BC15 4623.0
H2AC20 1385.0
H2BC4 -1116.0
H2AZ2 -2370.0
UBTF -6426.0


Metabolism of Angiotensinogen to Angiotensins
set Metabolism of Angiotensinogen to Angiotensins
setSize 12
pANOVA 0.00107
s.dist 0.545
p.adjustANOVA 0.0127


Top enriched genes
Top 20 genes
GeneID Gene Rank
ANPEP 10277
CTSG 9989
MME 9110
CTSD 9002
ACE 7514
CPA3 7413
GZMH 7172
AGT 6149
CTSZ 4472
ACE2 3222
ATP6AP2 1241
CES1 -6714

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANPEP 10277
CTSG 9989
MME 9110
CTSD 9002
ACE 7514
CPA3 7413
GZMH 7172
AGT 6149
CTSZ 4472
ACE2 3222
ATP6AP2 1241
CES1 -6714


Mitotic Telophase/Cytokinesis
set Mitotic Telophase/Cytokinesis
setSize 13
pANOVA 0.000923
s.dist -0.531
p.adjustANOVA 0.0115


Top enriched genes
Top 20 genes
GeneID Gene Rank
NIPBL -10706
STAG1 -9862
STAG2 -9389
SMC3 -9273
KIF23 -8830
SMC1A -7182
RAD21 -5905
PDS5B -4562
WAPL -4275
PLK1 -3989
KIF20A -3297
MAU2 -2908
PDS5A 1898

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NIPBL -10706
STAG1 -9862
STAG2 -9389
SMC3 -9273
KIF23 -8830
SMC1A -7182
RAD21 -5905
PDS5B -4562
WAPL -4275
PLK1 -3989
KIF20A -3297
MAU2 -2908
PDS5A 1898


mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
set mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
setSize 6
pANOVA 0.025
s.dist 0.528
p.adjustANOVA 0.124


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACADL 9706
HADHB 7206
DECR1 7020
HADHA 5291
ECI1 4787
ACADM -691

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACADL 9706
HADHB 7206
DECR1 7020
HADHA 5291
ECI1 4787
ACADM -691


Fibronectin matrix formation
set Fibronectin matrix formation
setSize 6
pANOVA 0.0266
s.dist 0.523
p.adjustANOVA 0.129


Top enriched genes
Top 20 genes
GeneID Gene Rank
CEACAM6 10252
ITGB1 9923
CEACAM8 9885
CEACAM1 5410
FN1 4057
ITGA5 -6569

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CEACAM6 10252
ITGB1 9923
CEACAM8 9885
CEACAM1 5410
FN1 4057
ITGA5 -6569


Response of EIF2AK1 (HRI) to heme deficiency
set Response of EIF2AK1 (HRI) to heme deficiency
setSize 14
pANOVA 0.000711
s.dist 0.523
p.adjustANOVA 0.00931


Top enriched genes
Top 20 genes
GeneID Gene Rank
GRB10 10508
PPP1R15A 9942
ATF3 9604
EIF2AK1 9317
CEBPG 8773
CEBPB 6889
TRIB3 6838
ATF4 6825
EIF2S3 4940
DDIT3 4765
EIF2S1 3891
EIF2S2 2416
ASNS -1217
ATF5 -6665

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB10 10508
PPP1R15A 9942
ATF3 9604
EIF2AK1 9317
CEBPG 8773
CEBPB 6889
TRIB3 6838
ATF4 6825
EIF2S3 4940
DDIT3 4765
EIF2S1 3891
EIF2S2 2416
ASNS -1217
ATF5 -6665


Axonal growth inhibition (RHOA activation)
set Axonal growth inhibition (RHOA activation)
setSize 7
pANOVA 0.0177
s.dist 0.518
p.adjustANOVA 0.098


Top enriched genes
Top 20 genes
GeneID Gene Rank
NGFR 10611
OMG 10120
RHOA 7622
RTN4 4984
ARHGDIA 2640
MCF2 1731
RTN4R 362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NGFR 10611
OMG 10120
RHOA 7622
RTN4 4984
ARHGDIA 2640
MCF2 1731
RTN4R 362


p75NTR regulates axonogenesis
set p75NTR regulates axonogenesis
setSize 7
pANOVA 0.0177
s.dist 0.518
p.adjustANOVA 0.098


Top enriched genes
Top 20 genes
GeneID Gene Rank
NGFR 10611
OMG 10120
RHOA 7622
RTN4 4984
ARHGDIA 2640
MCF2 1731
RTN4R 362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NGFR 10611
OMG 10120
RHOA 7622
RTN4 4984
ARHGDIA 2640
MCF2 1731
RTN4R 362


Prostanoid ligand receptors
set Prostanoid ligand receptors
setSize 8
pANOVA 0.0115
s.dist 0.516
p.adjustANOVA 0.0704


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTGER2 10709
PTGFR 8507
PTGDR2 8300
PTGER4 6947
TBXA2R 6896
PTGER3 3616
PTGDR 3239
PTGIR -4897

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGER2 10709
PTGFR 8507
PTGDR2 8300
PTGER4 6947
TBXA2R 6896
PTGER3 3616
PTGDR 3239
PTGIR -4897


DEx/H-box helicases activate type I IFN and inflammatory cytokines production
set DEx/H-box helicases activate type I IFN and inflammatory cytokines production
setSize 7
pANOVA 0.0182
s.dist -0.516
p.adjustANOVA 0.1


Top enriched genes
Top 20 genes
GeneID Gene Rank
IRF7 -10869
NFKB1 -9432
RELA -8239
NFKB2 -7458
DHX36 -5064
DHX9 -4702
MYD88 4758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRF7 -10869
NFKB1 -9432
RELA -8239
NFKB2 -7458
DHX36 -5064
DHX9 -4702
MYD88 4758


NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
set NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
setSize 32
pANOVA 5.27e-07
s.dist -0.512
p.adjustANOVA 2.99e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABCA1 -11154
ABCG8 -11072
ABCG1 -10985
KDM3A -10939
TNRC6A -10537
APOE -10211
EP300 -9611
TNRC6B -9333
TBL1XR1 -9204
NR1H3 -9102
TNRC6C -8752
NCOR1 -8299
NCOA1 -8279
AGO3 -8108
MOV10 -7679
RXRA -7106
KDM4A -6939
EEPD1 -6899
GPS2 -5867
HDAC3 -5574

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCA1 -11154
ABCG8 -11072
ABCG1 -10985
KDM3A -10939
TNRC6A -10537
APOE -10211
EP300 -9611
TNRC6B -9333
TBL1XR1 -9204
NR1H3 -9102
TNRC6C -8752
NCOR1 -8299
NCOA1 -8279
AGO3 -8108
MOV10 -7679
RXRA -7106
KDM4A -6939
EEPD1 -6899
GPS2 -5867
HDAC3 -5574
TBL1X -4524
AGO2 -4342
RXRB -4272
AGO1 -3380
KDM1B -1894
NCOR2 -1626
PLTP -876
ARL4C -775
KDM1A -26
CETP 485
NR1H2 3852
AGO4 6930


HDL remodeling
set HDL remodeling
setSize 6
pANOVA 0.0301
s.dist -0.511
p.adjustANOVA 0.141


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABCG1 -10985
LIPG -10818
APOE -10211
LCAT -2463
PLTP -876
CETP 485

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCG1 -10985
LIPG -10818
APOE -10211
LCAT -2463
PLTP -876
CETP 485


HDR through MMEJ (alt-NHEJ)
set HDR through MMEJ (alt-NHEJ)
setSize 12
pANOVA 0.00247
s.dist -0.505
p.adjustANOVA 0.0224


Top enriched genes
Top 20 genes
GeneID Gene Rank
BRCA2 -10424
FEN1 -9569
MRE11 -8788
PARP1 -8369
LIG3 -7811
RAD50 -7466
PARP2 -7048
POLQ -5779
RBBP8 -2913
NBN -790
RAD52 -680
XRCC1 786

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA2 -10424
FEN1 -9569
MRE11 -8788
PARP1 -8369
LIG3 -7811
RAD50 -7466
PARP2 -7048
POLQ -5779
RBBP8 -2913
NBN -790
RAD52 -680
XRCC1 786


Induction of Cell-Cell Fusion
set Induction of Cell-Cell Fusion
setSize 8
pANOVA 0.0137
s.dist 0.503
p.adjustANOVA 0.0812


Top enriched genes
Top 20 genes
GeneID Gene Rank
ANO5 9935
ANO7 8830
ANO6 8708
ANO10 7489
ANO8 4729
ACE2 3222
FURIN 856
ANO9 -1555

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANO5 9935
ANO7 8830
ANO6 8708
ANO10 7489
ANO8 4729
ACE2 3222
FURIN 856
ANO9 -1555


TGFBR3 expression
set TGFBR3 expression
setSize 20
pANOVA 0.000104
s.dist -0.501
p.adjustANOVA 0.0025


Top enriched genes
Top 20 genes
GeneID Gene Rank
TCF4 -10830
SMAD4 -10686
TNRC6A -10537
EP300 -9611
TNRC6B -9333
TNRC6C -8752
TGFBR3 -8728
AGO3 -8108
RARA -8014
SP1 -7724
MOV10 -7679
RXRA -7106
TCF3 -5176
KLF16 -4426
AGO2 -4342
TCF12 -4000
AGO1 -3380
SMAD3 447
AGO4 6930
HELLS 7090

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCF4 -10830
SMAD4 -10686
TNRC6A -10537
EP300 -9611
TNRC6B -9333
TNRC6C -8752
TGFBR3 -8728
AGO3 -8108
RARA -8014
SP1 -7724
MOV10 -7679
RXRA -7106
TCF3 -5176
KLF16 -4426
AGO2 -4342
TCF12 -4000
AGO1 -3380
SMAD3 447
AGO4 6930
HELLS 7090


Common Pathway of Fibrin Clot Formation
set Common Pathway of Fibrin Clot Formation
setSize 13
pANOVA 0.00177
s.dist 0.501
p.adjustANOVA 0.0181


Top enriched genes
Top 20 genes
GeneID Gene Rank
PROCR 10629
PRTN3 10442
F13A1 10233
PF4 10045
CD177 8341
F2R 7491
SERPINE2 6977
F5 6275
PROS1 5784
THBD 2126
F8 759
PF4V1 -98
PROC -10766

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROCR 10629
PRTN3 10442
F13A1 10233
PF4 10045
CD177 8341
F2R 7491
SERPINE2 6977
F5 6275
PROS1 5784
THBD 2126
F8 759
PF4V1 -98
PROC -10766


Linoleic acid (LA) metabolism
set Linoleic acid (LA) metabolism
setSize 7
pANOVA 0.0223
s.dist 0.499
p.adjustANOVA 0.115


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACSL1 10550
FADS1 8452
FADS2 8304
ELOVL1 7337
ELOVL3 2885
ABCD1 879
ELOVL5 -1812

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSL1 10550
FADS1 8452
FADS2 8304
ELOVL1 7337
ELOVL3 2885
ABCD1 879
ELOVL5 -1812


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.0226
s.dist 0.498
p.adjustANOVA 0.115


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLR2 10546
UBA52 8144
UBB 6122
RPS27A 4975
UBC 3574
B2M 2786
MRC1 385

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 10546
UBA52 8144
UBB 6122
RPS27A 4975
UBC 3574
B2M 2786
MRC1 385


Regulation of CDH11 mRNA translation by microRNAs
set Regulation of CDH11 mRNA translation by microRNAs
setSize 8
pANOVA 0.015
s.dist -0.497
p.adjustANOVA 0.0876


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6A -10537
TNRC6B -9333
TNRC6C -8752
AGO3 -8108
MOV10 -7679
AGO2 -4342
AGO1 -3380
AGO4 6930

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6A -10537
TNRC6B -9333
TNRC6C -8752
AGO3 -8108
MOV10 -7679
AGO2 -4342
AGO1 -3380
AGO4 6930


Regulation of NPAS4 mRNA translation
set Regulation of NPAS4 mRNA translation
setSize 8
pANOVA 0.015
s.dist -0.497
p.adjustANOVA 0.0876


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6A -10537
TNRC6B -9333
TNRC6C -8752
AGO3 -8108
MOV10 -7679
AGO2 -4342
AGO1 -3380
AGO4 6930

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6A -10537
TNRC6B -9333
TNRC6C -8752
AGO3 -8108
MOV10 -7679
AGO2 -4342
AGO1 -3380
AGO4 6930


Relaxin receptors
set Relaxin receptors
setSize 5
pANOVA 0.0547
s.dist 0.496
p.adjustANOVA 0.211


Top enriched genes
Top 20 genes
GeneID Gene Rank
RLN3 10027
INSL3 9036
RXFP4 8765
RXFP2 1914
RLN2 -3735

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RLN3 10027
INSL3 9036
RXFP4 8765
RXFP2 1914
RLN2 -3735


Phosphate bond hydrolysis by NTPDase proteins
set Phosphate bond hydrolysis by NTPDase proteins
setSize 5
pANOVA 0.0574
s.dist -0.491
p.adjustANOVA 0.219


Top enriched genes
Top 20 genes
GeneID Gene Rank
ENTPD7 -9884
ENTPD5 -9185
ENTPD6 -5465
ENTPD4 -5298
ENTPD1 1897

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ENTPD7 -9884
ENTPD5 -9185
ENTPD6 -5465
ENTPD4 -5298
ENTPD1 1897


Regulation of NPAS4 gene expression
set Regulation of NPAS4 gene expression
setSize 11
pANOVA 0.00515
s.dist -0.487
p.adjustANOVA 0.0403


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6A -10537
NR3C1 -9393
TNRC6B -9333
TNRC6C -8752
AGO3 -8108
MOV10 -7679
SRF -6167
AGO2 -4342
AGO1 -3380
REST -248
AGO4 6930

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6A -10537
NR3C1 -9393
TNRC6B -9333
TNRC6C -8752
AGO3 -8108
MOV10 -7679
SRF -6167
AGO2 -4342
AGO1 -3380
REST -248
AGO4 6930


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3`
## [1] "H2BC12"
## 
## [[1]]$`UP genesets.Activation of BAD and translocation to mitochondria`
## [1] "YWHAQ"
## 
## [[1]]$`UP genesets.Antimicrobial peptides`
## [1] "BPI"    "DEFA4"  "LCN2"   "PDZD11" "PRTN3"  "S100A8" "S100A9" "TLR2"  
## 
## [[1]]$`UP genesets.Biosynthesis of E-series 18(S)-resolvins`
## [1] "ALOX5" "HPGD" 
## 
## [[1]]$`UP genesets.Biosynthesis of EPA-derived SPMs`
## [1] "ALOX5" "HPGD"  "PTGS2"
## 
## [[1]]$`UP genesets.Biosynthesis of Lipoxins (LX)`
## [1] "ALOX5" "HPGD" 
## 
## [[1]]$`UP genesets.Common Pathway of Fibrin Clot Formation`
## [1] "PROCR" "PRTN3"
## 
## [[1]]$`UP genesets.Cross-presentation of particulate exogenous antigens (phagosomes)`
## [1] "NCF1"
## 
## [[1]]$`UP genesets.Formation of ATP by chemiosmotic coupling`
## character(0)
## 
## [[1]]$`UP genesets.Keratan sulfate degradation`
## [1] "HEXA"
## 
## [[1]]$`UP genesets.Metabolism of Angiotensinogen to Angiotensins`
## character(0)
## 
## [[1]]$`UP genesets.Protein repair`
## character(0)
## 
## [[1]]$`UP genesets.RNA Polymerase I Promoter Opening`
## [1] "H2BC12"
## 
## [[1]]$`UP genesets.Replacement of protamines by nucleosomes in the male pronucleus`
## [1] "H2BC12" "NPM2"  
## 
## [[1]]$`UP genesets.Response of EIF2AK1 (HRI) to heme deficiency`
## [1] "GRB10"
## 
## [[1]]$`UP genesets.Signal attenuation`
## [1] "GRB10" "INSR"  "IRS1"  "IRS2" 
## 
## [[1]]$`UP genesets.Synthesis of 12-eicosatetraenoic acid derivatives`
## [1] "GPX1"
## 
## [[1]]$`UP genesets.Synthesis of 15-eicosatetraenoic acid derivatives`
## [1] "ALOX15B" "GPX1"    "PTGS2"  
## 
## [[1]]$`UP genesets.Synthesis of 5-eicosatetraenoic acids`
## [1] "ALOX5" "GPX1" 
## 
## [[1]]$`UP genesets.Synthesis of Leukotrienes (LT) and Eoxins (EX)`
## [1] "ALOX5"
## 
## [[1]]$`DOWN genesets.Cohesin Loading onto Chromatin`
##  [1] "MAU2"  "NIPBL" "PDS5A" "PDS5B" "RAD21" "SMC1A" "SMC3"  "STAG1" "STAG2"
## [10] "WAPL" 
## 
## [[1]]$`DOWN genesets.Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)`
##  [1] "AAAS"    "GCK"     "GCKR"    "NDC1"    "NUP107"  "NUP133"  "NUP153" 
##  [8] "NUP155"  "NUP160"  "NUP188"  "NUP205"  "NUP210"  "NUP214"  "NUP35"  
## [15] "NUP37"   "NUP42"   "NUP43"   "NUP50"   "NUP54"   "NUP58"   "NUP62"  
## [22] "NUP85"   "NUP88"   "NUP93"   "NUP98"   "POM121"  "POM121C" "RAE1"   
## [29] "RANBP2"  "SEC13"   "SEH1L"   "TPR"    
## 
## [[1]]$`DOWN genesets.Export of Viral Ribonucleoproteins from Nucleus`
##  [1] "AAAS"    "HSPA1A"  "NDC1"    "NUP107"  "NUP133"  "NUP153"  "NUP155" 
##  [8] "NUP160"  "NUP188"  "NUP205"  "NUP210"  "NUP214"  "NUP35"   "NUP37"  
## [15] "NUP42"   "NUP43"   "NUP50"   "NUP54"   "NUP58"   "NUP62"   "NUP85"  
## [22] "NUP88"   "NUP93"   "NUP98"   "POM121"  "POM121C" "RAE1"    "RAN"    
## [29] "RANBP2"  "SEC13"   "SEH1L"   "TPR"     "XPO1"   
## 
## [[1]]$`DOWN genesets.HDR through MMEJ (alt-NHEJ)`
##  [1] "BRCA2" "FEN1"  "LIG3"  "MRE11" "NBN"   "PARP1" "PARP2" "POLQ"  "RAD50"
## [10] "RAD52" "RBBP8" "XRCC1"
## 
## [[1]]$`DOWN genesets.Interferon alpha/beta signaling`
##  [1] "ABCE1"   "ADAR"    "BST2"    "EIF2AK2" "GBP2"    "HLA-A"   "HLA-B"  
##  [8] "HLA-C"   "HLA-E"   "HLA-F"   "HLA-G"   "HLA-H"   "IFI27"   "IFI35"  
## [15] "IFI6"    "IFIT1"   "IFIT2"   "IFIT3"   "IFIT5"   "IFITM1"  "IFITM2" 
## [22] "IFITM3"  "IFNAR1"  "IFNAR2"  "IP6K2"   "IRF1"    "IRF2"    "IRF3"   
## [29] "IRF4"    "IRF5"    "IRF6"    "IRF7"    "IRF8"    "IRF9"    "ISG15"  
## [36] "ISG20"   "JAK1"    "KPNA1"   "KPNB1"   "MX1"     "MX2"     "OAS1"   
## [43] "OAS2"    "OAS3"    "OASL"    "PSMB8"   "PTPN1"   "PTPN11"  "PTPN6"  
## [50] "RNASEL"  "RPS27A"  "RSAD2"   "SAMHD1"  "STAT1"   "STAT2"   "TYK2"   
## [57] "UBA52"   "UBB"     "UBC"     "USP18"   "XAF1"   
## 
## [[1]]$`DOWN genesets.Interleukin-21 signaling`
## [1] "IL21R"  "IL2RG"  "JAK1"   "JAK3"   "STAT1"  "STAT3"  "STAT4"  "STAT5A"
## [9] "STAT5B"
## 
## [[1]]$`DOWN genesets.Mitotic Telophase/Cytokinesis`
##  [1] "KIF20A" "KIF23"  "MAU2"   "NIPBL"  "PDS5A"  "PDS5B"  "PLK1"   "RAD21" 
##  [9] "SMC1A"  "SMC3"   "STAG1"  "STAG2"  "WAPL"  
## 
## [[1]]$`DOWN genesets.NR1H2 and NR1H3-mediated signaling`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "FASN"    "GPS2"   
## [15] "HDAC3"   "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"   "MYLIP"  
## [22] "NCOA1"   "NCOR1"   "NCOR2"   "NR1H2"   "NR1H3"   "NRIP1"   "PLIN1"  
## [29] "PLTP"    "RXRA"    "RXRB"    "SCD"     "SREBF1"  "TBL1X"   "TBL1XR1"
## [36] "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "GPS2"    "HDAC3"  
## [15] "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"   "NCOA1"   "NCOR1"  
## [22] "NCOR2"   "NR1H2"   "NR1H3"   "PLTP"    "RXRA"    "RXRB"    "TBL1X"  
## [29] "TBL1XR1" "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.OAS antiviral response`
## [1] "ABCE1"  "FLNA"   "OAS1"   "OAS2"   "OAS3"   "OASL"   "PDE12"  "RNASEL"
## 
## [[1]]$`DOWN genesets.POLB-Dependent Long Patch Base Excision Repair`
## [1] "ADPRS" "APEX1" "FEN1"  "LIG1"  "PARG"  "PARP1" "PARP2" "POLB" 
## 
## [[1]]$`DOWN genesets.RORA activates gene expression`
##  [1] "CARM1"   "CHD9"    "CPT1A"   "CREBBP"  "EP300"   "HELZ2"   "MED1"   
##  [8] "NCOA1"   "NCOA2"   "NCOA6"   "PPARA"   "RORA"    "RXRA"    "SREBF1" 
## [15] "TBL1X"   "TBL1XR1" "TGS1"   
## 
## [[1]]$`DOWN genesets.Regulation of Glucokinase by Glucokinase Regulatory Protein`
##  [1] "AAAS"    "GCK"     "GCKR"    "NDC1"    "NUP107"  "NUP133"  "NUP153" 
##  [8] "NUP155"  "NUP160"  "NUP188"  "NUP205"  "NUP210"  "NUP214"  "NUP35"  
## [15] "NUP37"   "NUP42"   "NUP43"   "NUP50"   "NUP54"   "NUP58"   "NUP62"  
## [22] "NUP85"   "NUP88"   "NUP93"   "NUP98"   "POM121"  "POM121C" "RAE1"   
## [29] "RANBP2"  "SEC13"   "SEH1L"   "TPR"    
## 
## [[1]]$`DOWN genesets.Regulation of MECP2 expression and activity`
##  [1] "AGO1"    "AGO2"    "AGO3"    "AGO4"    "AURKB"   "CALM1"   "CAMK2A" 
##  [8] "CAMK2D"  "CAMK2G"  "CAMK4"   "CREB1"   "GPS2"    "HDAC1"   "HDAC2"  
## [15] "HDAC3"   "HIPK2"   "HTT"     "LBR"     "MECP2"   "MOV10"   "NCOR1"  
## [22] "NCOR2"   "PRKACA"  "SIN3A"   "TBL1X"   "TBL1XR1" "TNRC6A"  "TNRC6B" 
## [29] "TNRC6C" 
## 
## [[1]]$`DOWN genesets.Regulation of NPAS4 gene expression`
##  [1] "AGO1"   "AGO2"   "AGO3"   "AGO4"   "MOV10"  "NR3C1"  "REST"   "SRF"   
##  [9] "TNRC6A" "TNRC6B" "TNRC6C"
## 
## [[1]]$`DOWN genesets.SUMOylation of SUMOylation proteins`
##  [1] "AAAS"    "NDC1"    "NUP107"  "NUP133"  "NUP153"  "NUP155"  "NUP160" 
##  [8] "NUP188"  "NUP205"  "NUP210"  "NUP214"  "NUP35"   "NUP37"   "NUP42"  
## [15] "NUP43"   "NUP50"   "NUP54"   "NUP58"   "NUP62"   "NUP85"   "NUP88"  
## [22] "NUP93"   "NUP98"   "PIAS4"   "POM121"  "POM121C" "RAE1"    "RANBP2" 
## [29] "SEC13"   "SEH1L"   "SUMO1"   "SUMO2"   "TOPORS"  "TPR"     "UBE2I"  
## 
## [[1]]$`DOWN genesets.Synthesis of PIPs at the early endosome membrane`
##  [1] "FIG4"    "INPP4A"  "INPP4B"  "INPP5F"  "MTM1"    "MTMR10"  "MTMR12" 
##  [8] "MTMR2"   "MTMR4"   "PI4K2A"  "PI4K2B"  "PIK3C2A" "PIK3C3"  "PIK3R4" 
## [15] "PIKFYVE" "VAC14"  
## 
## [[1]]$`DOWN genesets.TGFBR3 expression`
##  [1] "AGO1"   "AGO2"   "AGO3"   "AGO4"   "EP300"  "HELLS"  "KLF16"  "MOV10" 
##  [9] "RARA"   "RXRA"   "SMAD3"  "SMAD4"  "SP1"    "TCF12"  "TCF3"   "TCF4"  
## [17] "TGFBR3" "TNRC6A" "TNRC6B" "TNRC6C"
## 
## [[1]]$`DOWN genesets.Transport of Ribonucleoproteins into the Host Nucleus`
##  [1] "AAAS"    "KPNA1"   "KPNB1"   "NDC1"    "NUP107"  "NUP133"  "NUP153" 
##  [8] "NUP155"  "NUP160"  "NUP188"  "NUP205"  "NUP210"  "NUP214"  "NUP35"  
## [15] "NUP37"   "NUP42"   "NUP43"   "NUP50"   "NUP54"   "NUP58"   "NUP62"  
## [22] "NUP85"   "NUP88"   "NUP93"   "NUP98"   "POM121"  "POM121C" "RAE1"   
## [29] "RANBP2"  "SEC13"   "SEH1L"   "TPR"    
## 
## [[1]]$`DOWN genesets.Vpr-mediated nuclear import of PICs`
##  [1] "AAAS"    "BANF1"   "HMGA1"   "KPNA1"   "NDC1"    "NUP107"  "NUP133" 
##  [8] "NUP153"  "NUP155"  "NUP160"  "NUP188"  "NUP205"  "NUP210"  "NUP214" 
## [15] "NUP35"   "NUP37"   "NUP42"   "NUP43"   "NUP50"   "NUP54"   "NUP58"  
## [22] "NUP62"   "NUP85"   "NUP88"   "NUP93"   "NUP98"   "POM121"  "POM121C"
## [29] "PSIP1"   "RAE1"    "RANBP2"  "SEC13"   "SEH1L"   "TPR"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report