date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 2.3372330
A1BG -0.1044447
A1BG-AS1 0.3112347
A1CF 0.9717804
A2M 2.6139639
A2M-AS1 2.4240591

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Formation of the ureteric bud 5 1.42e-03 0.824 3.39e-02
CD163 mediating an anti-inflammatory response 9 9.37e-05 0.752 3.55e-03
Protein repair 6 1.70e-03 0.740 3.80e-02
MECP2 regulates transcription of neuronal ligands 5 4.53e-03 -0.733 7.08e-02
Defective binding of VWF variant to GPIb:IX:V 7 9.04e-04 0.724 2.39e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 9.04e-04 0.724 2.39e-02
Tandem pore domain potassium channels 5 7.50e-03 -0.690 9.34e-02
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 2.15e-07 0.687 1.39e-05
RUNX1 regulates transcription of genes involved in BCR signaling 6 3.68e-03 0.685 6.51e-02
G2 Phase 5 1.82e-02 0.610 1.64e-01
Propionyl-CoA catabolism 5 1.83e-02 -0.609 1.64e-01
Mitochondrial RNA degradation 25 1.91e-07 0.602 1.37e-05
G2/M DNA replication checkpoint 5 2.10e-02 0.596 1.77e-01
Translocation of ZAP-70 to Immunological synapse 24 4.60e-07 -0.594 2.54e-05
Biosynthesis of Lipoxins (LX) 6 1.19e-02 0.593 1.25e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 2.91e-04 0.580 9.54e-03
LTC4-CYSLTR mediated IL4 production 5 2.49e-02 -0.579 1.90e-01
tRNA processing in the mitochondrion 24 1.57e-06 0.566 7.41e-05
Defects of platelet adhesion to exposed collagen 8 5.78e-03 0.563 8.05e-02
Formation of xylulose-5-phosphate 5 3.00e-02 -0.560 2.07e-01
POLB-Dependent Long Patch Base Excision Repair 8 6.08e-03 -0.560 8.27e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 1.04e-02 -0.559 1.16e-01
Defective LFNG causes SCDO3 5 3.34e-02 -0.549 2.20e-01
RHOT1 GTPase cycle 5 3.51e-02 0.544 2.27e-01
Synthesis of PI 5 4.01e-02 -0.530 2.48e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.00e-02 -0.526 1.13e-01
Interleukin-21 signaling 9 7.18e-03 -0.517 9.06e-02
Phenylalanine metabolism 5 4.54e-02 -0.517 2.68e-01
CD22 mediated BCR regulation 58 1.38e-11 0.513 1.33e-08
Estrogen-stimulated signaling through PRKCZ 6 3.02e-02 0.511 2.08e-01
RNA Polymerase I Promoter Opening 17 3.01e-04 0.506 9.68e-03
PD-1 signaling 28 3.73e-06 -0.505 1.71e-04
Coenzyme A biosynthesis 7 2.12e-02 -0.503 1.78e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 2.18e-02 0.501 1.79e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 3.24e-05 0.501 1.39e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 6.21e-03 0.500 8.27e-02
Phosphorylation of CD3 and TCR zeta chains 27 7.01e-06 -0.499 3.15e-04
Response to metal ions 6 3.54e-02 0.496 2.27e-01
Acetylcholine Neurotransmitter Release Cycle 11 4.49e-03 -0.495 7.08e-02
Signal attenuation 9 1.10e-02 0.490 1.18e-01
Estrogen biosynthesis 5 5.90e-02 0.488 3.06e-01
MET activates RAP1 and RAC1 10 7.91e-03 0.485 9.61e-02
Carnitine shuttle 12 3.82e-03 -0.482 6.59e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 3.89e-03 0.481 6.59e-02
ATF6 (ATF6-alpha) activates chaperones 12 4.09e-03 0.479 6.80e-02
Modulation by Mtb of host immune system 7 2.84e-02 0.478 2.01e-01
RUNX1 regulates expression of components of tight junctions 5 6.40e-02 0.478 3.21e-01
Formation of the active cofactor, UDP-glucuronate 5 6.68e-02 0.473 3.25e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 2.64e-04 0.471 8.79e-03
RUNX3 regulates BCL2L11 (BIM) transcription 5 7.12e-02 0.466 3.34e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Formation of the ureteric bud 5 1.42e-03 8.24e-01 3.39e-02
CD163 mediating an anti-inflammatory response 9 9.37e-05 7.52e-01 3.55e-03
Protein repair 6 1.70e-03 7.40e-01 3.80e-02
MECP2 regulates transcription of neuronal ligands 5 4.53e-03 -7.33e-01 7.08e-02
Defective binding of VWF variant to GPIb:IX:V 7 9.04e-04 7.24e-01 2.39e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 9.04e-04 7.24e-01 2.39e-02
Tandem pore domain potassium channels 5 7.50e-03 -6.90e-01 9.34e-02
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 2.15e-07 6.87e-01 1.39e-05
RUNX1 regulates transcription of genes involved in BCR signaling 6 3.68e-03 6.85e-01 6.51e-02
G2 Phase 5 1.82e-02 6.10e-01 1.64e-01
Propionyl-CoA catabolism 5 1.83e-02 -6.09e-01 1.64e-01
Mitochondrial RNA degradation 25 1.91e-07 6.02e-01 1.37e-05
G2/M DNA replication checkpoint 5 2.10e-02 5.96e-01 1.77e-01
Translocation of ZAP-70 to Immunological synapse 24 4.60e-07 -5.94e-01 2.54e-05
Biosynthesis of Lipoxins (LX) 6 1.19e-02 5.93e-01 1.25e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 2.91e-04 5.80e-01 9.54e-03
LTC4-CYSLTR mediated IL4 production 5 2.49e-02 -5.79e-01 1.90e-01
tRNA processing in the mitochondrion 24 1.57e-06 5.66e-01 7.41e-05
Defects of platelet adhesion to exposed collagen 8 5.78e-03 5.63e-01 8.05e-02
Formation of xylulose-5-phosphate 5 3.00e-02 -5.60e-01 2.07e-01
POLB-Dependent Long Patch Base Excision Repair 8 6.08e-03 -5.60e-01 8.27e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 1.04e-02 -5.59e-01 1.16e-01
Defective LFNG causes SCDO3 5 3.34e-02 -5.49e-01 2.20e-01
RHOT1 GTPase cycle 5 3.51e-02 5.44e-01 2.27e-01
Synthesis of PI 5 4.01e-02 -5.30e-01 2.48e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.00e-02 -5.26e-01 1.13e-01
Interleukin-21 signaling 9 7.18e-03 -5.17e-01 9.06e-02
Phenylalanine metabolism 5 4.54e-02 -5.17e-01 2.68e-01
CD22 mediated BCR regulation 58 1.38e-11 5.13e-01 1.33e-08
Estrogen-stimulated signaling through PRKCZ 6 3.02e-02 5.11e-01 2.08e-01
RNA Polymerase I Promoter Opening 17 3.01e-04 5.06e-01 9.68e-03
PD-1 signaling 28 3.73e-06 -5.05e-01 1.71e-04
Coenzyme A biosynthesis 7 2.12e-02 -5.03e-01 1.78e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 2.18e-02 5.01e-01 1.79e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 3.24e-05 5.01e-01 1.39e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 6.21e-03 5.00e-01 8.27e-02
Phosphorylation of CD3 and TCR zeta chains 27 7.01e-06 -4.99e-01 3.15e-04
Response to metal ions 6 3.54e-02 4.96e-01 2.27e-01
Acetylcholine Neurotransmitter Release Cycle 11 4.49e-03 -4.95e-01 7.08e-02
Signal attenuation 9 1.10e-02 4.90e-01 1.18e-01
Estrogen biosynthesis 5 5.90e-02 4.88e-01 3.06e-01
MET activates RAP1 and RAC1 10 7.91e-03 4.85e-01 9.61e-02
Carnitine shuttle 12 3.82e-03 -4.82e-01 6.59e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 3.89e-03 4.81e-01 6.59e-02
ATF6 (ATF6-alpha) activates chaperones 12 4.09e-03 4.79e-01 6.80e-02
Modulation by Mtb of host immune system 7 2.84e-02 4.78e-01 2.01e-01
RUNX1 regulates expression of components of tight junctions 5 6.40e-02 4.78e-01 3.21e-01
Formation of the active cofactor, UDP-glucuronate 5 6.68e-02 4.73e-01 3.25e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 2.64e-04 4.71e-01 8.79e-03
RUNX3 regulates BCL2L11 (BIM) transcription 5 7.12e-02 4.66e-01 3.34e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 3.65e-03 4.66e-01 6.51e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 7.21e-02 -4.64e-01 3.36e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 4.95e-02 4.63e-01 2.84e-01
Regulation of CDH11 gene transcription 5 7.38e-02 -4.62e-01 3.37e-01
Digestion 5 7.41e-02 4.61e-01 3.37e-01
Glucuronidation 9 1.66e-02 4.61e-01 1.53e-01
Neurotransmitter clearance 6 5.15e-02 4.59e-01 2.89e-01
Sperm Motility And Taxes 6 5.16e-02 -4.59e-01 2.89e-01
Defective factor IX causes hemophilia B 6 5.19e-02 4.58e-01 2.89e-01
Regulation of CDH11 mRNA translation by microRNAs 8 2.49e-02 -4.58e-01 1.90e-01
Regulation of NPAS4 mRNA translation 8 2.49e-02 -4.58e-01 1.90e-01
Classical antibody-mediated complement activation 69 4.83e-11 4.58e-01 2.19e-08
Scavenging of heme from plasma 70 5.67e-11 4.53e-01 2.19e-08
Miro GTPase Cycle 8 2.70e-02 4.52e-01 1.99e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.39e-02 4.49e-01 1.39e-01
Diseases of hemostasis 15 2.83e-03 4.45e-01 5.31e-02
Platelet Adhesion to exposed collagen 16 2.08e-03 4.45e-01 4.37e-02
rRNA processing in the mitochondrion 24 1.80e-04 4.42e-01 6.31e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.83e-03 4.42e-01 8.05e-02
Creatine metabolism 6 6.13e-02 -4.41e-01 3.14e-01
Glycerophospholipid catabolism 6 6.40e-02 -4.37e-01 3.21e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 6.79e-02 4.30e-01 3.30e-01
MET activates PI3K/AKT signaling 5 9.65e-02 4.29e-01 3.86e-01
Creation of C4 and C2 activators 71 7.28e-10 4.23e-01 1.41e-07
STAT3 nuclear events downstream of ALK signaling 11 1.55e-02 -4.21e-01 1.49e-01
CYP2E1 reactions 6 7.51e-02 -4.20e-01 3.41e-01
Digestion and absorption 7 5.51e-02 4.19e-01 2.97e-01
Regulation of NPAS4 gene expression 11 1.65e-02 -4.18e-01 1.52e-01
Proton-coupled monocarboxylate transport 6 7.65e-02 4.18e-01 3.45e-01
ROBO receptors bind AKAP5 7 5.65e-02 -4.16e-01 2.98e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.08e-02 4.16e-01 2.09e-01
TNFR1-mediated ceramide production 6 7.80e-02 -4.15e-01 3.49e-01
TGFBR3 expression 20 1.30e-03 -4.15e-01 3.19e-02
RHO GTPases activate PKNs 46 1.12e-06 4.15e-01 5.53e-05
MET receptor recycling 9 3.17e-02 4.13e-01 2.12e-01
Role of LAT2/NTAL/LAB on calcium mobilization 77 3.96e-10 4.12e-01 8.51e-08
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 5.92e-02 -4.12e-01 3.06e-01
Passive transport by Aquaporins 6 8.18e-02 4.10e-01 3.56e-01
Packaging Of Telomere Ends 18 2.61e-03 4.10e-01 5.12e-02
Molybdenum cofactor biosynthesis 6 8.45e-02 -4.07e-01 3.60e-01
Amyloid fiber formation 52 3.94e-07 4.06e-01 2.24e-05
APOBEC3G mediated resistance to HIV-1 infection 5 1.17e-01 -4.05e-01 4.12e-01
FCGR activation 76 1.06e-09 4.05e-01 1.70e-07
SIRT1 negatively regulates rRNA expression 22 1.07e-03 4.03e-01 2.76e-02
NFE2L2 regulates pentose phosphate pathway genes 8 4.90e-02 4.02e-01 2.84e-01
Neurotoxicity of clostridium toxins 9 3.71e-02 -4.01e-01 2.36e-01
Inactivation of CDC42 and RAC1 7 6.61e-02 4.01e-01 3.23e-01
CDH11 homotypic and heterotypic interactions 6 9.06e-02 -3.99e-01 3.75e-01
Uptake of dietary cobalamins into enterocytes 6 9.21e-02 -3.97e-01 3.77e-01
Fructose metabolism 7 6.92e-02 -3.97e-01 3.30e-01
RHOT2 GTPase cycle 7 6.98e-02 3.96e-01 3.31e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 3.73e-03 -3.95e-01 6.51e-02
Leading Strand Synthesis 14 1.09e-02 -3.93e-01 1.18e-01
Polymerase switching 14 1.09e-02 -3.93e-01 1.18e-01
Anchoring fibril formation 10 3.17e-02 3.92e-01 2.12e-01
Alternative complement activation 5 1.30e-01 -3.91e-01 4.29e-01
Regulation of Complement cascade 96 4.42e-11 3.89e-01 2.19e-08
Noncanonical activation of NOTCH3 8 5.75e-02 3.88e-01 3.01e-01
Mitochondrial Uncoupling 6 1.01e-01 -3.86e-01 3.94e-01
Post-transcriptional silencing by small RNAs 7 7.72e-02 -3.86e-01 3.48e-01
Acetylcholine regulates insulin secretion 9 4.59e-02 -3.84e-01 2.70e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 1.39e-01 -3.82e-01 4.43e-01
p130Cas linkage to MAPK signaling for integrins 11 2.83e-02 3.82e-01 2.01e-01
RSK activation 7 8.09e-02 3.81e-01 3.56e-01
Generation of second messenger molecules 38 4.91e-05 -3.81e-01 1.98e-03
GABA synthesis, release, reuptake and degradation 12 2.26e-02 -3.80e-01 1.82e-01
DNA methylation 18 5.29e-03 3.80e-01 7.74e-02
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 2.29e-02 3.79e-01 1.83e-01
Transport of connexons to the plasma membrane 12 2.29e-02 3.79e-01 1.83e-01
Lipophagy 7 8.23e-02 3.79e-01 3.56e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 8.23e-02 -3.79e-01 3.56e-01
LGI-ADAM interactions 9 4.96e-02 -3.78e-01 2.84e-01
Defects in biotin (Btn) metabolism 8 6.47e-02 -3.77e-01 3.21e-01
PTK6 Regulates Cell Cycle 6 1.11e-01 -3.76e-01 4.04e-01
RHO GTPases activate IQGAPs 25 1.22e-03 3.74e-01 3.05e-02
GP1b-IX-V activation signalling 12 2.52e-02 3.73e-01 1.91e-01
Activation of NOXA and translocation to mitochondria 5 1.50e-01 -3.72e-01 4.61e-01
Keratan sulfate degradation 9 5.40e-02 3.71e-01 2.97e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 9.08e-02 -3.69e-01 3.75e-01
Toxicity of botulinum toxin type D (botD) 5 1.54e-01 -3.69e-01 4.64e-01
Toxicity of botulinum toxin type F (botF) 5 1.54e-01 -3.69e-01 4.64e-01
Synthesis of 5-eicosatetraenoic acids 7 9.29e-02 3.67e-01 3.77e-01
Binding and Uptake of Ligands by Scavenger Receptors 94 8.28e-10 3.66e-01 1.45e-07
Disorders of Developmental Biology 12 2.81e-02 -3.66e-01 2.00e-01
Disorders of Nervous System Development 12 2.81e-02 -3.66e-01 2.00e-01
Loss of function of MECP2 in Rett syndrome 12 2.81e-02 -3.66e-01 2.00e-01
Pervasive developmental disorders 12 2.81e-02 -3.66e-01 2.00e-01
Platelet Aggregation (Plug Formation) 30 5.39e-04 3.65e-01 1.56e-02
Regulation of Expression and Function of Type II Classical Cadherins 25 1.63e-03 -3.64e-01 3.71e-02
Regulation of Homotypic Cell-Cell Adhesion 25 1.63e-03 -3.64e-01 3.71e-02
Maturation of hRSV A proteins 13 2.39e-02 3.62e-01 1.87e-01
Assembly of active LPL and LIPC lipase complexes 10 4.92e-02 3.59e-01 2.84e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 3.82e-04 -3.57e-01 1.19e-02
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.68e-01 3.56e-01 4.90e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 2.06e-08 3.56e-01 1.89e-06
Cellular hexose transport 14 2.13e-02 -3.56e-01 1.78e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 2.09e-03 -3.55e-01 4.37e-02
Initial triggering of complement 79 5.01e-08 3.55e-01 4.40e-06
Regulated proteolysis of p75NTR 11 4.38e-02 3.51e-01 2.60e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.10e-01 3.49e-01 4.04e-01
PINK1-PRKN Mediated Mitophagy 31 8.00e-04 3.48e-01 2.21e-02
Regulation of CDH11 Expression and Function 23 4.00e-03 -3.47e-01 6.72e-02
Frs2-mediated activation 11 4.66e-02 3.46e-01 2.74e-01
Prolonged ERK activation events 13 3.08e-02 3.46e-01 2.09e-01
Complement cascade 100 2.34e-09 3.45e-01 3.23e-07
Branched-chain ketoacid dehydrogenase kinase deficiency 5 1.83e-01 3.44e-01 5.12e-01
Suppression of apoptosis 7 1.15e-01 3.44e-01 4.09e-01
Organic anion transporters 7 1.16e-01 -3.43e-01 4.09e-01
Formation of Fibrin Clot (Clotting Cascade) 26 2.52e-03 3.42e-01 5.02e-02
Insulin receptor recycling 24 3.74e-03 3.42e-01 6.51e-02
HDR through MMEJ (alt-NHEJ) 12 4.06e-02 -3.41e-01 2.49e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 4.12e-02 3.40e-01 2.50e-01
PCNA-Dependent Long Patch Base Excision Repair 21 7.15e-03 -3.39e-01 9.06e-02
Negative feedback regulation of MAPK pathway 6 1.52e-01 3.38e-01 4.61e-01
OAS antiviral response 8 9.86e-02 -3.37e-01 3.90e-01
Post-chaperonin tubulin folding pathway 18 1.33e-02 3.37e-01 1.36e-01
Activation of the phototransduction cascade 8 1.01e-01 3.34e-01 3.94e-01
Cation-coupled Chloride cotransporters 6 1.58e-01 -3.33e-01 4.71e-01
Regulation of PTEN localization 9 8.59e-02 3.31e-01 3.65e-01
Assembly of the ORC complex at the origin of replication 23 6.07e-03 3.30e-01 8.27e-02
Crosslinking of collagen fibrils 15 2.69e-02 3.30e-01 1.99e-01
FCGR3A-mediated phagocytosis 121 3.74e-10 3.30e-01 8.51e-08
Leishmania phagocytosis 121 3.74e-10 3.30e-01 8.51e-08
Parasite infection 121 3.74e-10 3.30e-01 8.51e-08
Glycosphingolipid transport 7 1.32e-01 -3.28e-01 4.31e-01
NrCAM interactions 6 1.65e-01 -3.27e-01 4.87e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.34e-01 -3.27e-01 4.34e-01
Physiological factors 9 9.08e-02 3.26e-01 3.75e-01
Presynaptic depolarization and calcium channel opening 8 1.13e-01 -3.24e-01 4.06e-01
NADE modulates death signalling 5 2.12e-01 3.23e-01 5.44e-01
BBSome-mediated cargo-targeting to cilium 22 8.85e-03 -3.22e-01 1.05e-01
Glycogen synthesis 11 6.49e-02 3.21e-01 3.21e-01
Cleavage of the damaged purine 22 9.09e-03 3.21e-01 1.06e-01
Depurination 22 9.09e-03 3.21e-01 1.06e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 9.09e-03 3.21e-01 1.06e-01
Regulation of CDH19 Expression and Function 6 1.74e-01 -3.21e-01 5.00e-01
Apoptosis induced DNA fragmentation 10 7.97e-02 3.20e-01 3.55e-01
Attachment of GPI anchor to uPAR 7 1.43e-01 -3.20e-01 4.50e-01
AKT phosphorylates targets in the nucleus 9 9.68e-02 -3.20e-01 3.86e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 8.05e-02 3.19e-01 3.56e-01
Synthesis of PIPs at the Golgi membrane 16 2.73e-02 -3.19e-01 2.00e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 5.60e-02 3.19e-01 2.98e-01
Sema4D induced cell migration and growth-cone collapse 19 1.62e-02 3.19e-01 1.51e-01
Signaling by activated point mutants of FGFR1 5 2.18e-01 3.18e-01 5.51e-01
Organic cation transport 8 1.19e-01 3.18e-01 4.13e-01
Organic cation/anion/zwitterion transport 8 1.19e-01 3.18e-01 4.13e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 1.49e-01 -3.15e-01 4.61e-01
Role of phospholipids in phagocytosis 88 3.44e-07 3.14e-01 2.01e-05
Netrin mediated repulsion signals 5 2.24e-01 -3.14e-01 5.56e-01
Processive synthesis on the lagging strand 15 3.52e-02 -3.14e-01 2.27e-01
FCERI mediated Ca+2 mobilization 92 2.00e-07 3.14e-01 1.38e-05
NRIF signals cell death from the nucleus 15 3.57e-02 3.13e-01 2.28e-01
Syndecan interactions 26 5.70e-03 3.13e-01 8.05e-02
Polymerase switching on the C-strand of the telomere 26 5.83e-03 -3.12e-01 8.05e-02
Long-term potentiation 18 2.18e-02 -3.12e-01 1.79e-01
Lagging Strand Synthesis 20 1.57e-02 -3.12e-01 1.50e-01
Resolution of Abasic Sites (AP sites) 38 8.93e-04 -3.11e-01 2.39e-02
TGFBR3 regulates TGF-beta signaling 8 1.28e-01 -3.11e-01 4.25e-01
FCERI mediated MAPK activation 93 2.73e-07 3.08e-01 1.70e-05
Prostanoid ligand receptors 8 1.31e-01 3.08e-01 4.30e-01
Spry regulation of FGF signaling 16 3.35e-02 3.07e-01 2.20e-01
Nectin/Necl trans heterodimerization 5 2.37e-01 -3.05e-01 5.73e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 1.14e-01 3.04e-01 4.08e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 2.00e-01 -3.02e-01 5.31e-01
Olfactory Signaling Pathway 61 4.51e-05 3.02e-01 1.85e-03
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 3.81e-02 2.99e-01 2.38e-01
PI-3K cascade:FGFR1 13 6.24e-02 2.99e-01 3.18e-01
Glycogen breakdown (glycogenolysis) 12 7.34e-02 2.98e-01 3.37e-01
Synthesis of PE 12 7.35e-02 2.98e-01 3.37e-01
NR1H2 and NR1H3-mediated signaling 39 1.30e-03 -2.98e-01 3.19e-02
Regulation of MITF-M-dependent genes involved in apoptosis 16 3.93e-02 -2.98e-01 2.43e-01
Platelet degranulation 106 1.19e-07 2.98e-01 9.36e-06
Transport of RCbl within the body 8 1.47e-01 2.96e-01 4.57e-01
FCERI mediated NF-kB activation 129 7.41e-09 2.95e-01 8.42e-07
Regulation of actin dynamics for phagocytic cup formation 123 1.77e-08 2.94e-01 1.71e-06
IRAK1 recruits IKK complex 14 5.70e-02 2.94e-01 2.99e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 5.70e-02 2.94e-01 2.99e-01
Heme biosynthesis 13 6.69e-02 -2.94e-01 3.25e-01
Interleukin-1 processing 8 1.52e-01 -2.93e-01 4.61e-01
Interleukin-9 signaling 8 1.54e-01 -2.91e-01 4.64e-01
Fibronectin matrix formation 6 2.17e-01 2.91e-01 5.51e-01
Common Pathway of Fibrin Clot Formation 13 6.94e-02 2.91e-01 3.30e-01
TGFBR3 PTM regulation 10 1.12e-01 2.90e-01 4.06e-01
Sema4D in semaphorin signaling 22 1.84e-02 2.90e-01 1.64e-01
Intrinsic Pathway of Fibrin Clot Formation 15 5.17e-02 2.90e-01 2.89e-01
Activation of AMPK downstream of NMDARs 20 2.48e-02 2.90e-01 1.90e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.64e-02 2.89e-01 1.52e-01
2-LTR circle formation 7 1.85e-01 -2.89e-01 5.17e-01
Activation of BAD and translocation to mitochondria 15 5.29e-02 2.89e-01 2.92e-01
FCGR3A-mediated IL10 synthesis 99 6.93e-07 2.89e-01 3.72e-05
ARMS-mediated activation 6 2.21e-01 2.88e-01 5.55e-01
Mitophagy 38 2.10e-03 2.88e-01 4.37e-02
Anti-inflammatory response favouring Leishmania parasite infection 132 1.14e-08 2.88e-01 1.16e-06
Leishmania parasite growth and survival 132 1.14e-08 2.88e-01 1.16e-06
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.23e-01 -2.87e-01 5.56e-01
Cleavage of the damaged pyrimidine 27 9.95e-03 2.87e-01 1.13e-01
Depyrimidination 27 9.95e-03 2.87e-01 1.13e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 9.95e-03 2.87e-01 1.13e-01
Glycogen metabolism 21 2.33e-02 2.86e-01 1.85e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.41e-02 -2.86e-01 3.21e-01
MASTL Facilitates Mitotic Progression 10 1.18e-01 2.85e-01 4.13e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 4.81e-02 2.85e-01 2.81e-01
Negative regulation of FGFR1 signaling 25 1.36e-02 2.85e-01 1.37e-01
Advanced glycosylation endproduct receptor signaling 12 8.76e-02 2.85e-01 3.68e-01
Expression and translocation of olfactory receptors 56 2.28e-04 2.85e-01 7.73e-03
Aflatoxin activation and detoxification 14 6.54e-02 -2.84e-01 3.22e-01
Formation of tubulin folding intermediates by CCT/TriC 21 2.44e-02 2.84e-01 1.89e-01
Condensation of Prophase Chromosomes 27 1.09e-02 2.83e-01 1.18e-01
Sphingolipid de novo biosynthesis 34 4.29e-03 2.83e-01 7.08e-02
Reactions specific to the complex N-glycan synthesis pathway 7 1.96e-01 2.82e-01 5.25e-01
Formation of ATP by chemiosmotic coupling 20 2.90e-02 2.82e-01 2.03e-01
Response to elevated platelet cytosolic Ca2+ 110 3.22e-07 2.82e-01 1.95e-05
Condensation of Prometaphase Chromosomes 11 1.06e-01 2.82e-01 3.98e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 1.48e-02 2.82e-01 1.44e-01
IFNG signaling activates MAPKs 8 1.68e-01 2.82e-01 4.90e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 2.68e-03 2.81e-01 5.12e-02
Nucleosome assembly 38 2.68e-03 2.81e-01 5.12e-02
Antimicrobial peptides 34 4.56e-03 2.81e-01 7.08e-02
Type I hemidesmosome assembly 8 1.69e-01 -2.81e-01 4.92e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 9.27e-02 2.80e-01 3.77e-01
Biotin transport and metabolism 11 1.08e-01 -2.80e-01 4.01e-01
COPI-independent Golgi-to-ER retrograde traffic 45 1.20e-03 2.79e-01 3.05e-02
Methionine salvage pathway 6 2.38e-01 -2.78e-01 5.73e-01
Josephin domain DUBs 10 1.28e-01 2.78e-01 4.25e-01
Removal of the Flap Intermediate 14 7.27e-02 -2.77e-01 3.37e-01
Infection with Mycobacterium tuberculosis 26 1.45e-02 2.77e-01 1.43e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 5.57e-02 -2.76e-01 2.98e-01
Negative regulation of FGFR3 signaling 21 2.85e-02 2.76e-01 2.01e-01
Fructose catabolism 5 2.85e-01 -2.76e-01 6.19e-01
CREB3 factors activate genes 6 2.42e-01 2.76e-01 5.78e-01
Non-integrin membrane-ECM interactions 51 6.65e-04 2.75e-01 1.88e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 5.65e-02 2.75e-01 2.98e-01
Synthesis of PIPs at the ER membrane 5 2.87e-01 -2.75e-01 6.21e-01
G alpha (z) signalling events 36 4.32e-03 2.75e-01 7.08e-02
Na+/Cl- dependent neurotransmitter transporters 8 1.79e-01 2.74e-01 5.05e-01
SARS-CoV-2 modulates autophagy 11 1.17e-01 -2.73e-01 4.12e-01
Regulation of FOXO transcriptional activity by acetylation 10 1.37e-01 2.72e-01 4.39e-01
Erythrocytes take up carbon dioxide and release oxygen 11 1.19e-01 2.71e-01 4.13e-01
O2/CO2 exchange in erythrocytes 11 1.19e-01 2.71e-01 4.13e-01
Cobalamin (Cbl) metabolism 7 2.14e-01 -2.71e-01 5.49e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.06e-01 -2.70e-01 3.98e-01
Regulation of MECP2 expression and activity 29 1.20e-02 -2.70e-01 1.25e-01
Serotonin Neurotransmitter Release Cycle 15 7.20e-02 -2.68e-01 3.36e-01
ADP signalling through P2Y purinoceptor 12 18 4.89e-02 2.68e-01 2.84e-01
Scavenging by Class A Receptors 14 8.25e-02 2.68e-01 3.56e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 1.90e-01 2.67e-01 5.19e-01
Butyrophilin (BTN) family interactions 9 1.67e-01 -2.66e-01 4.90e-01
B-WICH complex positively regulates rRNA expression 45 2.05e-03 2.66e-01 4.37e-02
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 3.07e-01 -2.64e-01 6.33e-01
Interleukin-18 signaling 6 2.63e-01 2.64e-01 5.96e-01
Signaling by ALK 24 2.53e-02 -2.64e-01 1.91e-01
Maturation of spike protein 9683686 5 3.09e-01 2.63e-01 6.35e-01
Smooth Muscle Contraction 34 7.98e-03 2.63e-01 9.63e-02
Amine ligand-binding receptors 10 1.51e-01 -2.63e-01 4.61e-01
RHO GTPases Activate ROCKs 18 5.42e-02 2.62e-01 2.97e-01
Reelin signalling pathway 5 3.12e-01 2.61e-01 6.38e-01
Xenobiotics 12 1.21e-01 -2.58e-01 4.15e-01
Defects in vitamin and cofactor metabolism 21 4.13e-02 -2.57e-01 2.50e-01
Inhibition of DNA recombination at telomere 33 1.06e-02 2.57e-01 1.17e-01
Synthesis of PG 8 2.09e-01 -2.57e-01 5.42e-01
Dermatan sulfate biosynthesis 6 2.76e-01 2.57e-01 6.07e-01
Phase 3 - rapid repolarisation 6 2.77e-01 -2.56e-01 6.09e-01
PI-3K cascade:FGFR3 10 1.61e-01 2.56e-01 4.79e-01
SOS-mediated signalling 7 2.41e-01 2.56e-01 5.78e-01
Base-Excision Repair, AP Site Formation 29 1.71e-02 2.56e-01 1.56e-01
RNA Polymerase I Promoter Escape 45 2.99e-03 2.56e-01 5.51e-02
Removal of the Flap Intermediate from the C-strand 17 6.81e-02 -2.56e-01 3.30e-01
EGFR downregulation 27 2.20e-02 2.55e-01 1.80e-01
Cell surface interactions at the vascular wall 176 5.71e-09 2.54e-01 6.90e-07
TRAF3-dependent IRF activation pathway 13 1.12e-01 -2.54e-01 4.06e-01
Vitamin B2 (riboflavin) metabolism 6 2.83e-01 -2.53e-01 6.18e-01
RUNX3 regulates p14-ARF 10 1.67e-01 2.52e-01 4.89e-01
RHOJ GTPase cycle 50 2.08e-03 2.52e-01 4.37e-02
Hedgehog ligand biogenesis 47 2.86e-03 2.51e-01 5.31e-02
Telomere C-strand (Lagging Strand) Synthesis 34 1.16e-02 -2.50e-01 1.23e-01
Signaling by the B Cell Receptor (BCR) 150 1.21e-07 2.50e-01 9.36e-06
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 3.34e-01 -2.50e-01 6.50e-01
Urea cycle 7 2.53e-01 2.50e-01 5.87e-01
Synthesis of PC 23 3.86e-02 2.49e-01 2.40e-01
Bicarbonate transporters 9 1.98e-01 -2.48e-01 5.27e-01
MET promotes cell motility 33 1.39e-02 2.47e-01 1.39e-01
Activation of SMO 13 1.22e-01 -2.47e-01 4.18e-01
Adherens junctions interactions 41 6.17e-03 -2.47e-01 8.27e-02
CHL1 interactions 8 2.27e-01 2.47e-01 5.59e-01
Aggrephagy 34 1.32e-02 2.46e-01 1.35e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 3.42e-01 -2.45e-01 6.60e-01
PI3K events in ERBB4 signaling 6 2.99e-01 -2.45e-01 6.31e-01
Vpr-mediated nuclear import of PICs 34 1.35e-02 -2.45e-01 1.37e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 7.38e-02 -2.43e-01 3.37e-01
Maturation of spike protein 9694548 36 1.21e-02 2.42e-01 1.26e-01
Signaling by NODAL 15 1.06e-01 2.41e-01 3.98e-01
Nucleotide biosynthesis 12 1.48e-01 -2.41e-01 4.60e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 1.88e-01 2.40e-01 5.18e-01
Pentose phosphate pathway 13 1.33e-01 2.40e-01 4.33e-01
IRE1alpha activates chaperones 46 4.88e-03 2.40e-01 7.42e-02
Telomere C-strand synthesis initiation 13 1.35e-01 -2.40e-01 4.35e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 9.91e-02 2.38e-01 3.91e-01
Maternal to zygotic transition (MZT) 72 4.93e-04 2.37e-01 1.44e-02
Cell-extracellular matrix interactions 16 1.01e-01 2.36e-01 3.94e-01
Sodium/Proton exchangers 7 2.79e-01 -2.36e-01 6.13e-01
Interleukin-20 family signaling 17 9.20e-02 -2.36e-01 3.77e-01
The phototransduction cascade 26 3.77e-02 2.35e-01 2.37e-01
Signal transduction by L1 20 6.89e-02 2.35e-01 3.30e-01
Neurexins and neuroligins 40 1.03e-02 -2.34e-01 1.15e-01
NPAS4 regulates expression of target genes 16 1.05e-01 2.34e-01 3.98e-01
Fc epsilon receptor (FCERI) signaling 179 6.95e-08 2.34e-01 5.84e-06
Other interleukin signaling 19 7.81e-02 -2.33e-01 3.49e-01
Chemokine receptors bind chemokines 39 1.16e-02 2.33e-01 1.23e-01
Integrin signaling 22 6.04e-02 2.31e-01 3.10e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 1.34e-06 2.31e-01 6.47e-05
Regulation of TLR by endogenous ligand 15 1.22e-01 -2.31e-01 4.16e-01
Trafficking and processing of endosomal TLR 13 1.51e-01 -2.30e-01 4.61e-01
Platelet activation, signaling and aggregation 223 3.39e-09 2.30e-01 4.37e-07
NFE2L2 regulating tumorigenic genes 11 1.90e-01 2.28e-01 5.18e-01
Senescence-Associated Secretory Phenotype (SASP) 65 1.49e-03 2.28e-01 3.47e-02
Sodium/Calcium exchangers 9 2.37e-01 2.28e-01 5.73e-01
HDMs demethylate histones 22 6.49e-02 -2.27e-01 3.21e-01
DNA strand elongation 32 2.61e-02 -2.27e-01 1.96e-01
Acyl chain remodelling of PI 10 2.14e-01 2.27e-01 5.49e-01
Pyrimidine salvage 10 2.14e-01 2.27e-01 5.49e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.99e-02 -2.27e-01 2.84e-01
Nuclear events stimulated by ALK signaling in cancer 33 2.43e-02 -2.27e-01 1.89e-01
Early Phase of HIV Life Cycle 14 1.42e-01 -2.26e-01 4.49e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 5.50e-02 2.26e-01 2.97e-01
Axonal growth inhibition (RHOA activation) 7 3.01e-01 2.26e-01 6.33e-01
p75NTR regulates axonogenesis 7 3.01e-01 2.26e-01 6.33e-01
Glutathione synthesis and recycling 10 2.17e-01 -2.25e-01 5.51e-01
ChREBP activates metabolic gene expression 7 3.03e-01 2.25e-01 6.33e-01
The activation of arylsulfatases 10 2.19e-01 2.25e-01 5.51e-01
Norepinephrine Neurotransmitter Release Cycle 14 1.46e-01 -2.24e-01 4.57e-01
Processive synthesis on the C-strand of the telomere 19 9.08e-02 -2.24e-01 3.75e-01
Selective autophagy 77 6.73e-04 2.24e-01 1.88e-02
Transcriptional regulation of granulopoiesis 44 1.02e-02 2.24e-01 1.14e-01
Phosphate bond hydrolysis by NUDT proteins 7 3.06e-01 2.23e-01 6.33e-01
Neurofascin interactions 5 3.87e-01 2.23e-01 7.08e-01
Recycling pathway of L1 40 1.46e-02 2.23e-01 1.43e-01
RAS processing 23 6.59e-02 2.21e-01 3.23e-01
Negative regulation of FGFR4 signaling 22 7.28e-02 2.21e-01 3.37e-01
Receptor Mediated Mitophagy 11 2.05e-01 2.21e-01 5.39e-01
Interactions of Vpr with host cellular proteins 37 2.02e-02 -2.21e-01 1.74e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 3.94e-01 -2.20e-01 7.13e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 3.94e-01 -2.20e-01 7.13e-01
RIP-mediated NFkB activation via ZBP1 17 1.18e-01 -2.19e-01 4.12e-01
Translation of Structural Proteins 9694635 56 4.62e-03 2.19e-01 7.09e-02
Golgi Associated Vesicle Biogenesis 55 5.12e-03 2.18e-01 7.61e-02
Recycling of bile acids and salts 10 2.33e-01 -2.18e-01 5.65e-01
Cardiogenesis 16 1.31e-01 -2.18e-01 4.30e-01
VEGF binds to VEGFR leading to receptor dimerization 5 4.01e-01 2.17e-01 7.14e-01
VEGF ligand-receptor interactions 5 4.01e-01 2.17e-01 7.14e-01
Amino acid transport across the plasma membrane 26 5.60e-02 2.17e-01 2.98e-01
Mismatch Repair 15 1.48e-01 -2.16e-01 4.60e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 3.52e-02 2.15e-01 2.27e-01
Sensing of DNA Double Strand Breaks 6 3.62e-01 -2.15e-01 6.81e-01
Meiotic recombination 37 2.38e-02 2.15e-01 1.87e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 4.06e-01 -2.15e-01 7.14e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 4.07e-01 2.14e-01 7.14e-01
Maple Syrup Urine Disease 5 4.07e-01 2.14e-01 7.14e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 5.42e-02 2.14e-01 2.97e-01
G beta:gamma signalling through BTK 15 1.51e-01 2.14e-01 4.61e-01
Sema4D mediated inhibition of cell attachment and migration 7 3.27e-01 2.14e-01 6.48e-01
RHO GTPases activate PAKs 20 9.96e-02 2.13e-01 3.91e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 4.12e-01 2.12e-01 7.15e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 3.80e-02 -2.12e-01 2.38e-01
Phase 2 - plateau phase 11 2.24e-01 -2.12e-01 5.56e-01
Nef Mediated CD8 Down-regulation 7 3.33e-01 2.11e-01 6.50e-01
Initiation of Nuclear Envelope (NE) Reformation 19 1.11e-01 2.11e-01 4.04e-01
Hh mutants abrogate ligand secretion 43 1.67e-02 2.11e-01 1.53e-01
Interleukin-6 family signaling 20 1.03e-01 -2.11e-01 3.94e-01
Cytosolic sulfonation of small molecules 18 1.22e-01 2.11e-01 4.16e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 3.34e-01 2.11e-01 6.51e-01
Signaling by Retinoic Acid 29 4.96e-02 -2.11e-01 2.84e-01
Fertilization 12 2.07e-01 -2.11e-01 5.42e-01
XBP1(S) activates chaperone genes 44 1.59e-02 2.10e-01 1.51e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 3.37e-01 2.10e-01 6.52e-01
Apoptotic cleavage of cell adhesion proteins 8 3.05e-01 2.10e-01 6.33e-01
Negative regulation of MET activity 18 1.24e-01 2.10e-01 4.19e-01
Regulation of IFNA/IFNB signaling 12 2.09e-01 -2.09e-01 5.42e-01
Reversible hydration of carbon dioxide 8 3.06e-01 2.09e-01 6.33e-01
Synthesis of GDP-mannose 6 3.78e-01 2.08e-01 6.99e-01
Amino acids regulate mTORC1 48 1.26e-02 2.08e-01 1.30e-01
Activation of the AP-1 family of transcription factors 10 2.55e-01 2.08e-01 5.90e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 1.64e-01 -2.08e-01 4.85e-01
RHOQ GTPase cycle 55 7.73e-03 2.08e-01 9.57e-02
Regulation of RUNX1 Expression and Activity 18 1.28e-01 -2.07e-01 4.25e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 1.02e-01 2.06e-01 3.94e-01
Interleukin-27 signaling 11 2.38e-01 2.05e-01 5.73e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 6.40e-03 2.05e-01 8.36e-02
TICAM1-dependent activation of IRF3/IRF7 13 2.01e-01 -2.05e-01 5.31e-01
Hh mutants are degraded by ERAD 42 2.18e-02 2.05e-01 1.79e-01
FRS-mediated FGFR1 signaling 15 1.70e-01 2.04e-01 4.92e-01
Gap junction assembly 17 1.45e-01 2.04e-01 4.55e-01
Signaling by Insulin receptor 63 5.14e-03 2.04e-01 7.61e-02
Interleukin-15 signaling 14 1.87e-01 -2.04e-01 5.18e-01
Miscellaneous transport and binding events 20 1.15e-01 2.04e-01 4.09e-01
CD209 (DC-SIGN) signaling 20 1.15e-01 -2.03e-01 4.09e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 1.36e-01 -2.03e-01 4.38e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 3.63e-03 2.02e-01 6.51e-02
PI3K/AKT activation 8 3.22e-01 2.02e-01 6.46e-01
MAPK3 (ERK1) activation 10 2.70e-01 2.01e-01 6.04e-01
Unfolded Protein Response (UPR) 84 1.44e-03 2.01e-01 3.39e-02
Transcriptional Regulation by VENTX 39 2.99e-02 -2.01e-01 2.07e-01
Plasma lipoprotein remodeling 18 1.40e-01 2.01e-01 4.46e-01
CLEC7A/inflammasome pathway 6 3.94e-01 -2.01e-01 7.13e-01
Integration of provirus 9 2.97e-01 -2.01e-01 6.30e-01
NFE2L2 regulating MDR associated enzymes 8 3.26e-01 2.01e-01 6.48e-01
Uptake and function of anthrax toxins 11 2.50e-01 2.00e-01 5.86e-01
Signaling by FLT3 fusion proteins 18 1.42e-01 -2.00e-01 4.49e-01
Regulation of CDH11 function 10 2.75e-01 -2.00e-01 6.07e-01
Apoptotic execution phase 46 1.95e-02 1.99e-01 1.70e-01
Regulation of IFNG signaling 14 1.98e-01 1.99e-01 5.27e-01
Killing mechanisms 9 3.04e-01 -1.98e-01 6.33e-01
WNT5:FZD7-mediated leishmania damping 9 3.04e-01 -1.98e-01 6.33e-01
Activation of RAC1 downstream of NMDARs 7 3.64e-01 1.98e-01 6.84e-01
Signaling by MST1 5 4.44e-01 -1.98e-01 7.36e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 2.59e-01 -1.97e-01 5.92e-01
Netrin-1 signaling 35 4.40e-02 1.97e-01 2.61e-01
Prevention of phagosomal-lysosomal fusion 9 3.07e-01 1.97e-01 6.34e-01
Telomere Extension By Telomerase 23 1.03e-01 1.97e-01 3.94e-01
Metabolic disorders of biological oxidation enzymes 26 8.29e-02 1.96e-01 3.56e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 6.37e-02 1.96e-01 3.21e-01
VLDLR internalisation and degradation 16 1.76e-01 1.95e-01 5.05e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 1.93e-02 1.95e-01 1.69e-01
Leishmania infection 211 1.04e-06 1.95e-01 5.28e-05
Parasitic Infection Pathways 211 1.04e-06 1.95e-01 5.28e-05
Formation of the Editosome 6 4.08e-01 1.95e-01 7.14e-01
mRNA Editing: C to U Conversion 6 4.08e-01 1.95e-01 7.14e-01
RNA Polymerase III Chain Elongation 18 1.52e-01 1.95e-01 4.61e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 3.11e-02 1.95e-01 2.10e-01
ABC transporter disorders 60 9.13e-03 1.95e-01 1.06e-01
Defective CFTR causes cystic fibrosis 47 2.10e-02 1.95e-01 1.77e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 4.09e-01 1.95e-01 7.14e-01
Caspase activation via Death Receptors in the presence of ligand 16 1.78e-01 -1.94e-01 5.05e-01
Nuclear Receptor transcription pathway 40 3.35e-02 -1.94e-01 2.20e-01
Interleukin-35 Signalling 12 2.45e-01 1.94e-01 5.81e-01
CD28 dependent Vav1 pathway 12 2.45e-01 -1.94e-01 5.81e-01
Depolymerization of the Nuclear Lamina 15 1.96e-01 1.93e-01 5.25e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.36e-01 -1.93e-01 4.37e-01
Glutamate Neurotransmitter Release Cycle 20 1.36e-01 -1.93e-01 4.37e-01
Sulfide oxidation to sulfate 5 4.57e-01 -1.92e-01 7.49e-01
Late SARS-CoV-2 Infection Events 64 8.11e-03 1.91e-01 9.73e-02
Response of Mtb to phagocytosis 22 1.21e-01 1.91e-01 4.15e-01
Transport of fatty acids 5 4.60e-01 1.91e-01 7.52e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 2.17e-01 1.91e-01 5.51e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 2.75e-01 -1.90e-01 6.07e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.89e-01 1.90e-01 5.18e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 6.43e-02 -1.89e-01 3.21e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 6.43e-02 -1.89e-01 3.21e-01
Glycogen storage diseases 13 2.38e-01 1.89e-01 5.73e-01
IL-6-type cytokine receptor ligand interactions 13 2.40e-01 -1.88e-01 5.76e-01
Beta-catenin phosphorylation cascade 17 1.79e-01 1.88e-01 5.05e-01
RHO GTPases Activate WASPs and WAVEs 35 5.50e-02 1.87e-01 2.97e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 4.68e-01 1.87e-01 7.59e-01
Defensins 8 3.59e-01 1.87e-01 6.79e-01
Phase 4 - resting membrane potential 9 3.31e-01 -1.87e-01 6.50e-01
ECM proteoglycans 48 2.53e-02 1.87e-01 1.91e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 2.28e-01 -1.86e-01 5.59e-01
STAT5 activation downstream of FLT3 ITD mutants 9 3.33e-01 1.86e-01 6.50e-01
Purine salvage 12 2.65e-01 -1.86e-01 5.98e-01
PDH complex synthesizes acetyl-CoA from PYR 5 4.72e-01 1.86e-01 7.62e-01
Mitochondrial unfolded protein response (UPRmt) 17 1.86e-01 -1.85e-01 5.17e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 4.32e-01 1.85e-01 7.31e-01
TRIF-mediated programmed cell death 9 3.36e-01 -1.85e-01 6.51e-01
Class I peroxisomal membrane protein import 20 1.52e-01 -1.85e-01 4.61e-01
Signaling by MET 68 8.37e-03 1.85e-01 9.98e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 1.88e-01 -1.84e-01 5.18e-01
Signaling by LTK 10 3.13e-01 -1.84e-01 6.38e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.15e-02 1.84e-01 1.23e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 4.35e-01 -1.84e-01 7.34e-01
Interleukin-23 signaling 7 3.99e-01 -1.84e-01 7.14e-01
Regulation of TP53 Activity through Methylation 19 1.65e-01 -1.84e-01 4.87e-01
SUMOylation of SUMOylation proteins 35 6.03e-02 -1.83e-01 3.10e-01
HSF1 activation 26 1.06e-01 -1.83e-01 3.98e-01
Defects in cobalamin (B12) metabolism 13 2.53e-01 -1.83e-01 5.87e-01
EPHA-mediated growth cone collapse 21 1.47e-01 1.83e-01 4.57e-01
Calnexin/calreticulin cycle 26 1.06e-01 1.83e-01 3.98e-01
EPH-Ephrin signaling 81 4.47e-03 1.83e-01 7.08e-02
Polo-like kinase mediated events 16 2.08e-01 1.82e-01 5.42e-01
TNFR1-induced proapoptotic signaling 24 1.24e-01 -1.81e-01 4.19e-01
PRC2 methylates histones and DNA 27 1.03e-01 1.81e-01 3.94e-01
Basigin interactions 23 1.32e-01 1.81e-01 4.31e-01
Signaling by EGFR 48 3.00e-02 1.81e-01 2.07e-01
Kidney development 17 1.96e-01 1.81e-01 5.25e-01
Sphingolipid catabolism 11 2.99e-01 1.81e-01 6.31e-01
Intraflagellar transport 47 3.23e-02 -1.81e-01 2.14e-01
Maturation of nucleoprotein 9694631 15 2.26e-01 1.80e-01 5.59e-01
Attenuation phase 23 1.34e-01 -1.80e-01 4.34e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 1.49e-02 1.80e-01 1.44e-01
Negative regulation of FGFR2 signaling 24 1.27e-01 1.80e-01 4.25e-01
Nuclear import of Rev protein 34 6.93e-02 -1.80e-01 3.30e-01
Linoleic acid (LA) metabolism 7 4.10e-01 -1.80e-01 7.15e-01
Aryl hydrocarbon receptor signalling 6 4.46e-01 -1.80e-01 7.37e-01
The NLRP3 inflammasome 16 2.15e-01 -1.79e-01 5.49e-01
Hemostasis 562 3.71e-13 1.79e-01 7.18e-10
Heme degradation 11 3.04e-01 1.79e-01 6.33e-01
Phospholipase C-mediated cascade; FGFR2 8 3.81e-01 -1.79e-01 7.02e-01
Cargo trafficking to the periciliary membrane 47 3.37e-02 -1.79e-01 2.20e-01
Laminin interactions 26 1.16e-01 1.78e-01 4.09e-01
Export of Viral Ribonucleoproteins from Nucleus 33 7.65e-02 -1.78e-01 3.45e-01
Formation of the cornified envelope 36 6.43e-02 1.78e-01 3.21e-01
Cell-cell junction organization 60 1.72e-02 -1.78e-01 1.56e-01
Malate-aspartate shuttle 8 3.85e-01 -1.77e-01 7.06e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 4.73e-02 1.77e-01 2.77e-01
Pregnenolone biosynthesis 10 3.33e-01 -1.77e-01 6.50e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 2.77e-02 1.76e-01 2.00e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 6.33e-02 1.76e-01 3.21e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.47e-02 1.76e-01 1.44e-01
RHOBTB1 GTPase cycle 23 1.43e-01 1.76e-01 4.51e-01
DCC mediated attractive signaling 13 2.73e-01 1.75e-01 6.07e-01
HSF1-dependent transactivation 30 9.66e-02 -1.75e-01 3.86e-01
Sphingolipid metabolism 91 3.86e-03 1.75e-01 6.59e-02
DARPP-32 events 22 1.55e-01 1.75e-01 4.65e-01
Repression of WNT target genes 14 2.57e-01 -1.75e-01 5.91e-01
Gluconeogenesis 19 1.87e-01 -1.75e-01 5.18e-01
SHC-mediated cascade:FGFR1 13 2.76e-01 1.75e-01 6.07e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.80e-02 1.75e-01 3.89e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.99e-01 -1.74e-01 7.84e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 1.11e-01 1.74e-01 4.04e-01
Transferrin endocytosis and recycling 26 1.25e-01 1.74e-01 4.21e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 7.09e-02 1.74e-01 3.33e-01
Thromboxane signalling through TP receptor 20 1.78e-01 1.74e-01 5.05e-01
Vif-mediated degradation of APOBEC3G 41 5.49e-02 1.73e-01 2.97e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 4.27e-01 -1.73e-01 7.30e-01
Regulation of Apoptosis 40 5.82e-02 1.73e-01 3.04e-01
Prostacyclin signalling through prostacyclin receptor 16 2.32e-01 1.73e-01 5.64e-01
Signaling by FGFR3 32 9.16e-02 1.72e-01 3.77e-01
Regulation of RAS by GAPs 55 2.71e-02 1.72e-01 1.99e-01
Erythrocytes take up oxygen and release carbon dioxide 7 4.30e-01 1.72e-01 7.31e-01
Regulation of NFE2L2 gene expression 8 3.99e-01 -1.72e-01 7.14e-01
Nuclear events mediated by NFE2L2 82 7.10e-03 1.72e-01 9.06e-02
SUMOylation of DNA methylation proteins 16 2.34e-01 -1.72e-01 5.67e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 1.92e-02 1.72e-01 1.69e-01
Signaling by FGFR4 32 9.28e-02 1.72e-01 3.77e-01
Diseases of Base Excision Repair 5 5.07e-01 -1.72e-01 7.90e-01
Interleukin-2 signaling 11 3.26e-01 -1.71e-01 6.48e-01
Pyrimidine catabolism 9 3.75e-01 1.71e-01 6.96e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 2.22e-02 1.71e-01 1.80e-01
trans-Golgi Network Vesicle Budding 69 1.43e-02 1.71e-01 1.41e-01
Costimulation by the CD28 family 74 1.12e-02 -1.70e-01 1.20e-01
Aspartate and asparagine metabolism 9 3.76e-01 -1.70e-01 6.98e-01
Phospholipase C-mediated cascade: FGFR1 8 4.04e-01 1.70e-01 7.14e-01
Vitamin C (ascorbate) metabolism 8 4.06e-01 -1.70e-01 7.14e-01
P2Y receptors 10 3.53e-01 -1.70e-01 6.73e-01
Cytosolic iron-sulfur cluster assembly 13 2.90e-01 -1.69e-01 6.26e-01
Maturation of nucleoprotein 9683610 11 3.33e-01 1.69e-01 6.50e-01
Signalling to ERKs 32 9.96e-02 1.68e-01 3.91e-01
SARS-CoV-1 activates/modulates innate immune responses 40 6.60e-02 -1.68e-01 3.23e-01
Phosphate bond hydrolysis by NTPDase proteins 5 5.16e-01 -1.68e-01 8.01e-01
Cristae formation 33 9.62e-02 1.67e-01 3.86e-01
Regulation of ornithine decarboxylase (ODC) 38 7.45e-02 1.67e-01 3.39e-01
Gap junction trafficking 28 1.26e-01 1.67e-01 4.23e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 8.73e-02 1.67e-01 3.68e-01
Interferon gamma signaling 90 6.26e-03 -1.67e-01 8.27e-02
Golgi-to-ER retrograde transport 123 1.42e-03 1.67e-01 3.39e-02
Regulation of TP53 Activity through Association with Co-factors 13 2.99e-01 -1.67e-01 6.31e-01
Signal amplification 28 1.29e-01 1.66e-01 4.25e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 1.90e-01 1.65e-01 5.18e-01
Neurodegenerative Diseases 21 1.90e-01 1.65e-01 5.18e-01
Ca2+ activated K+ channels 6 4.83e-01 1.65e-01 7.71e-01
Defective RIPK1-mediated regulated necrosis 7 4.51e-01 -1.64e-01 7.43e-01
Rap1 signalling 14 2.87e-01 1.64e-01 6.21e-01
Regulation of PTEN stability and activity 55 3.53e-02 1.64e-01 2.27e-01
Regulation of PTEN gene transcription 59 2.94e-02 -1.64e-01 2.05e-01
Peptide ligand-binding receptors 101 4.43e-03 1.64e-01 7.08e-02
Metabolism of polyamines 46 5.50e-02 1.63e-01 2.97e-01
NGF-stimulated transcription 32 1.10e-01 -1.63e-01 4.04e-01
COPI-mediated anterograde transport 92 6.90e-03 1.63e-01 8.89e-02
Regulation of localization of FOXO transcription factors 11 3.50e-01 1.63e-01 6.69e-01
Signaling by high-kinase activity BRAF mutants 33 1.06e-01 1.63e-01 3.98e-01
Erythropoietin activates STAT5 6 4.91e-01 -1.63e-01 7.76e-01
Role of second messengers in netrin-1 signaling 6 4.91e-01 -1.62e-01 7.76e-01
RNA Polymerase III Transcription Termination 23 1.78e-01 1.62e-01 5.05e-01
G-protein activation 19 2.22e-01 1.62e-01 5.55e-01
Zinc influx into cells by the SLC39 gene family 9 4.01e-01 1.62e-01 7.14e-01
NS1 Mediated Effects on Host Pathways 40 7.79e-02 -1.61e-01 3.49e-01
NFE2L2 regulating ER-stress associated genes 5 5.33e-01 1.61e-01 8.10e-01
Degradation of GLI1 by the proteasome 46 5.89e-02 1.61e-01 3.06e-01
Synaptic adhesion-like molecules 17 2.51e-01 -1.61e-01 5.87e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.15e-01 -1.61e-01 4.09e-01
Inwardly rectifying K+ channels 24 1.73e-01 1.61e-01 4.98e-01
Apoptotic cleavage of cellular proteins 35 9.96e-02 1.61e-01 3.91e-01
Deactivation of the beta-catenin transactivating complex 36 9.52e-02 -1.61e-01 3.85e-01
CASP8 activity is inhibited 11 3.57e-01 -1.60e-01 6.76e-01
Dimerization of procaspase-8 11 3.57e-01 -1.60e-01 6.76e-01
Regulation by c-FLIP 11 3.57e-01 -1.60e-01 6.76e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 8.34e-02 1.60e-01 3.56e-01
p53-Independent DNA Damage Response 39 8.34e-02 1.60e-01 3.56e-01
p53-Independent G1/S DNA damage checkpoint 39 8.34e-02 1.60e-01 3.56e-01
Mitochondrial calcium ion transport 22 1.93e-01 1.60e-01 5.22e-01
TRAF6 mediated IRF7 activation 15 2.83e-01 -1.60e-01 6.18e-01
Uptake and function of diphtheria toxin 6 4.98e-01 -1.60e-01 7.83e-01
KEAP1-NFE2L2 pathway 107 4.45e-03 1.59e-01 7.08e-02
Pexophagy 10 3.84e-01 -1.59e-01 7.05e-01
Miscellaneous substrates 7 4.67e-01 -1.59e-01 7.59e-01
PLC beta mediated events 40 8.24e-02 -1.59e-01 3.56e-01
Adenylate cyclase activating pathway 8 4.38e-01 -1.58e-01 7.36e-01
MAPK1 (ERK2) activation 9 4.11e-01 1.58e-01 7.15e-01
Synthesis of very long-chain fatty acyl-CoAs 22 2.01e-01 1.58e-01 5.31e-01
Other semaphorin interactions 16 2.76e-01 1.57e-01 6.07e-01
Myoclonic epilepsy of Lafora 8 4.41e-01 1.57e-01 7.36e-01
NF-kB is activated and signals survival 12 3.46e-01 1.57e-01 6.65e-01
APC-Cdc20 mediated degradation of Nek2A 26 1.66e-01 1.57e-01 4.87e-01
RHOG GTPase cycle 71 2.22e-02 1.57e-01 1.80e-01
Signaling by MAPK mutants 6 5.07e-01 -1.57e-01 7.90e-01
Eicosanoids 6 5.07e-01 1.56e-01 7.90e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 5.57e-02 1.56e-01 2.98e-01
SUMOylation of chromatin organization proteins 57 4.11e-02 -1.56e-01 2.50e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 3.92e-01 -1.56e-01 7.13e-01
Interferon alpha/beta signaling 64 3.11e-02 -1.56e-01 2.10e-01
Zygotic genome activation (ZGA) 5 5.50e-01 -1.55e-01 8.22e-01
Interleukin-2 family signaling 38 1.00e-01 -1.54e-01 3.93e-01
L1CAM interactions 100 7.78e-03 1.54e-01 9.57e-02
Degradation of DVL 43 8.15e-02 1.54e-01 3.56e-01
Vitamin D (calciferol) metabolism 11 3.78e-01 -1.53e-01 6.99e-01
Vitamin B5 (pantothenate) metabolism 20 2.35e-01 -1.53e-01 5.68e-01
RHO GTPase Effectors 258 2.20e-05 1.53e-01 9.68e-04
Keratinization 37 1.07e-01 1.53e-01 3.98e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 4.83e-01 -1.53e-01 7.71e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 5.55e-01 -1.53e-01 8.25e-01
Notch-HLH transcription pathway 28 1.62e-01 -1.53e-01 4.82e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 3.06e-01 1.53e-01 6.33e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 3.06e-01 1.53e-01 6.33e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 3.06e-01 1.53e-01 6.33e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 3.06e-01 1.53e-01 6.33e-01
Signaling by CTNNB1 phospho-site mutants 15 3.06e-01 1.53e-01 6.33e-01
Signaling by GSK3beta mutants 15 3.06e-01 1.53e-01 6.33e-01
RHOBTB GTPase Cycle 35 1.19e-01 1.52e-01 4.13e-01
Regulation of gene expression in beta cells 8 4.58e-01 -1.51e-01 7.49e-01
Tryptophan catabolism 12 3.66e-01 -1.51e-01 6.85e-01
MAP2K and MAPK activation 36 1.19e-01 1.50e-01 4.13e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.12e-01 -1.50e-01 7.15e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.70e-01 -1.49e-01 6.89e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 2.26e-01 1.49e-01 5.59e-01
Phospholipase C-mediated cascade; FGFR4 6 5.27e-01 -1.49e-01 8.06e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 4.51e-04 1.49e-01 1.36e-02
DNA Damage/Telomere Stress Induced Senescence 42 9.59e-02 1.48e-01 3.86e-01
Viral Messenger RNA Synthesis 44 8.87e-02 -1.48e-01 3.72e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 1.40e-01 1.48e-01 4.46e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.18e-01 1.48e-01 5.51e-01
Mucopolysaccharidoses 11 3.95e-01 1.48e-01 7.13e-01
MET activates RAS signaling 10 4.18e-01 1.48e-01 7.22e-01
Signaling by RAF1 mutants 37 1.20e-01 1.48e-01 4.13e-01
Interleukin-10 signaling 38 1.15e-01 -1.48e-01 4.09e-01
Vitamin B1 (thiamin) metabolism 5 5.68e-01 1.48e-01 8.30e-01
rRNA modification in the nucleus and cytosol 59 5.00e-02 1.48e-01 2.84e-01
PI-3K cascade:FGFR4 11 3.97e-01 1.48e-01 7.13e-01
Degradation of GLI2 by the proteasome 45 8.69e-02 1.47e-01 3.67e-01
GAB1 signalosome 15 3.23e-01 1.47e-01 6.46e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 2.02e-01 1.47e-01 5.33e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 6.92e-02 1.47e-01 3.30e-01
Maturation of protein 3a 9683673 9 4.45e-01 -1.47e-01 7.36e-01
Maturation of protein 3a 9694719 9 4.45e-01 -1.47e-01 7.36e-01
Aquaporin-mediated transport 38 1.17e-01 1.47e-01 4.12e-01
ADORA2B mediated anti-inflammatory cytokines production 36 1.28e-01 1.47e-01 4.25e-01
SUMOylation of DNA damage response and repair proteins 77 2.63e-02 -1.46e-01 1.96e-01
MET activates PTK2 signaling 23 2.27e-01 1.46e-01 5.59e-01
FRS-mediated FGFR3 signaling 12 3.83e-01 1.45e-01 7.04e-01
Activation of G protein gated Potassium channels 20 2.60e-01 1.45e-01 5.92e-01
G protein gated Potassium channels 20 2.60e-01 1.45e-01 5.92e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 2.60e-01 1.45e-01 5.92e-01
Clathrin-mediated endocytosis 128 4.58e-03 1.45e-01 7.08e-02
Protein-protein interactions at synapses 61 5.02e-02 -1.45e-01 2.85e-01
Regulation of RUNX3 expression and activity 45 9.26e-02 1.45e-01 3.77e-01
G-protein mediated events 44 9.68e-02 -1.45e-01 3.86e-01
Metabolism of non-coding RNA 53 6.85e-02 -1.45e-01 3.30e-01
snRNP Assembly 53 6.85e-02 -1.45e-01 3.30e-01
AMPK inhibits chREBP transcriptional activation activity 6 5.40e-01 1.45e-01 8.16e-01
Defective pyroptosis 27 1.94e-01 1.44e-01 5.22e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 2.66e-01 -1.44e-01 5.99e-01
ER-Phagosome pathway 75 3.19e-02 1.43e-01 2.12e-01
Interactions of Rev with host cellular proteins 37 1.32e-01 -1.43e-01 4.31e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 1.13e-01 1.43e-01 4.06e-01
Signaling by RAS mutants 41 1.13e-01 1.43e-01 4.06e-01
Signaling by moderate kinase activity BRAF mutants 41 1.13e-01 1.43e-01 4.06e-01
Signaling downstream of RAS mutants 41 1.13e-01 1.43e-01 4.06e-01
Protein ubiquitination 71 3.75e-02 1.43e-01 2.37e-01
Rev-mediated nuclear export of HIV RNA 35 1.44e-01 -1.43e-01 4.53e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 1.10e-01 1.42e-01 4.04e-01
Synthesis of PIPs at the late endosome membrane 11 4.14e-01 1.42e-01 7.16e-01
Protein folding 83 2.54e-02 1.42e-01 1.91e-01
Diseases associated with surfactant metabolism 6 5.49e-01 1.41e-01 8.22e-01
Neutrophil degranulation 458 2.14e-07 1.41e-01 1.39e-05
ABC-family proteins mediated transport 81 2.80e-02 1.41e-01 2.00e-01
Activation of NF-kappaB in B cells 54 7.28e-02 1.41e-01 3.37e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 4.90e-01 1.41e-01 7.76e-01
Gap junction trafficking and regulation 30 1.82e-01 1.41e-01 5.09e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 5.50e-01 -1.41e-01 8.22e-01
Arachidonate production from DAG 5 5.86e-01 1.41e-01 8.46e-01
Signaling by ERBB2 TMD/JMD mutants 17 3.15e-01 -1.41e-01 6.39e-01
Signaling by BMP 23 2.43e-01 -1.41e-01 5.79e-01
PKMTs methylate histone lysines 44 1.07e-01 -1.41e-01 3.98e-01
Insulin receptor signalling cascade 40 1.24e-01 1.40e-01 4.19e-01
Assembly of the pre-replicative complex 87 2.38e-02 1.40e-01 1.87e-01
SUMOylation of DNA replication proteins 46 1.00e-01 -1.40e-01 3.93e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 8.12e-02 1.40e-01 3.56e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 3.66e-01 -1.40e-01 6.85e-01
EGFR Transactivation by Gastrin 7 5.23e-01 -1.40e-01 8.06e-01
Synthesis of pyrophosphates in the cytosol 8 4.95e-01 -1.39e-01 7.78e-01
ALK mutants bind TKIs 11 4.25e-01 -1.39e-01 7.30e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 1.49e-01 -1.39e-01 4.61e-01
TNFs bind their physiological receptors 25 2.30e-01 -1.39e-01 5.63e-01
Synthesis, secretion, and deacylation of Ghrelin 11 4.26e-01 -1.39e-01 7.30e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 2.33e-02 1.38e-01 1.85e-01
SUMO E3 ligases SUMOylate target proteins 161 2.46e-03 -1.38e-01 4.99e-02
Interleukin receptor SHC signaling 23 2.51e-01 -1.38e-01 5.87e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 2.62e-01 -1.38e-01 5.96e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.52e-01 -1.38e-01 4.61e-01
Lysosphingolipid and LPA receptors 11 4.29e-01 -1.38e-01 7.31e-01
Asymmetric localization of PCP proteins 49 9.55e-02 1.38e-01 3.85e-01
Macroautophagy 128 7.22e-03 1.37e-01 9.06e-02
RHO GTPases activate CIT 18 3.14e-01 1.37e-01 6.38e-01
PCP/CE pathway 75 4.04e-02 1.37e-01 2.48e-01
Mitotic Telophase/Cytokinesis 13 3.93e-01 -1.37e-01 7.13e-01
TP53 Regulates Metabolic Genes 78 3.68e-02 1.37e-01 2.35e-01
Signaling by FGFR2 61 6.49e-02 1.37e-01 3.21e-01
APC/C:Cdc20 mediated degradation of Securin 55 8.03e-02 1.36e-01 3.56e-01
GLI3 is processed to GLI3R by the proteasome 46 1.10e-01 1.36e-01 4.04e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 2.49e-01 1.36e-01 5.84e-01
Vesicle-mediated transport 669 1.96e-09 1.36e-01 2.92e-07
SHC1 events in ERBB4 signaling 10 4.57e-01 -1.36e-01 7.49e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 5.64e-01 1.36e-01 8.30e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.15e-01 1.35e-01 5.49e-01
SLC15A4:TASL-dependent IRF5 activation 6 5.67e-01 1.35e-01 8.30e-01
Chondroitin sulfate biosynthesis 12 4.19e-01 1.35e-01 7.23e-01
SUMOylation 167 2.66e-03 -1.35e-01 5.12e-02
ER Quality Control Compartment (ERQC) 21 2.86e-01 1.35e-01 6.19e-01
Displacement of DNA glycosylase by APEX1 9 4.85e-01 -1.35e-01 7.72e-01
RUNX1 regulates estrogen receptor mediated transcription 6 5.69e-01 -1.34e-01 8.30e-01
Semaphorin interactions 56 8.21e-02 1.34e-01 3.56e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 3.11e-01 -1.34e-01 6.37e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 1.70e-01 1.34e-01 4.92e-01
Transport of the SLBP independent Mature mRNA 35 1.70e-01 -1.34e-01 4.92e-01
HATs acetylate histones 92 2.68e-02 1.34e-01 1.99e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 1.54e-01 -1.34e-01 4.64e-01
GPER1 signaling 38 1.54e-01 1.33e-01 4.64e-01
Incretin synthesis, secretion, and inactivation 14 3.88e-01 1.33e-01 7.08e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 3.88e-01 1.33e-01 7.08e-01
Chaperonin-mediated protein folding 77 4.32e-02 1.33e-01 2.58e-01
ROS and RNS production in phagocytes 30 2.07e-01 1.33e-01 5.42e-01
Signaling by Hippo 18 3.29e-01 1.33e-01 6.50e-01
Alpha-oxidation of phytanate 6 5.73e-01 -1.33e-01 8.35e-01
Surfactant metabolism 21 2.93e-01 1.33e-01 6.28e-01
Ubiquitin-dependent degradation of Cyclin D 39 1.52e-01 1.33e-01 4.61e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.43e-01 1.32e-01 4.51e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 2.20e-01 1.32e-01 5.53e-01
DNA Replication Pre-Initiation 103 2.09e-02 1.32e-01 1.77e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 3.62e-01 -1.32e-01 6.81e-01
Phenylalanine and tyrosine metabolism 9 4.94e-01 -1.32e-01 7.78e-01
HS-GAG biosynthesis 20 3.09e-01 1.31e-01 6.35e-01
Folding of actin by CCT/TriC 10 4.72e-01 1.31e-01 7.62e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 2.57e-01 -1.31e-01 5.91e-01
Fatty acids 6 5.79e-01 -1.31e-01 8.40e-01
Heme signaling 45 1.29e-01 -1.31e-01 4.25e-01
Signaling by NOTCH4 70 5.85e-02 1.31e-01 3.05e-01
PERK regulates gene expression 30 2.16e-01 1.30e-01 5.51e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.98e-01 1.30e-01 7.14e-01
Activated NTRK2 signals through FRS2 and FRS3 8 5.23e-01 1.30e-01 8.06e-01
eNOS activation 12 4.36e-01 1.30e-01 7.34e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 3.03e-01 1.30e-01 6.33e-01
APC/C-mediated degradation of cell cycle proteins 75 5.25e-02 1.29e-01 2.91e-01
Regulation of mitotic cell cycle 75 5.25e-02 1.29e-01 2.91e-01
Resolution of Sister Chromatid Cohesion 116 1.61e-02 1.29e-01 1.51e-01
Autophagy 142 7.88e-03 1.29e-01 9.61e-02
activated TAK1 mediates p38 MAPK activation 23 2.84e-01 1.29e-01 6.18e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 8.67e-02 1.29e-01 3.67e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 5.55e-01 1.29e-01 8.25e-01
Cilium Assembly 186 2.44e-03 -1.29e-01 4.99e-02
APC/C:Cdc20 mediated degradation of Cyclin B 24 2.76e-01 1.28e-01 6.07e-01
Downstream signaling of activated FGFR3 17 3.59e-01 1.28e-01 6.79e-01
RUNX3 regulates NOTCH signaling 14 4.06e-01 1.28e-01 7.14e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 4.16e-02 1.28e-01 2.50e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 4.16e-02 1.28e-01 2.50e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 4.16e-02 1.28e-01 2.50e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 4.26e-01 -1.28e-01 7.30e-01
APC truncation mutants have impaired AXIN binding 14 4.09e-01 1.27e-01 7.14e-01
AXIN missense mutants destabilize the destruction complex 14 4.09e-01 1.27e-01 7.14e-01
Signaling by AMER1 mutants 14 4.09e-01 1.27e-01 7.14e-01
Signaling by APC mutants 14 4.09e-01 1.27e-01 7.14e-01
Signaling by AXIN mutants 14 4.09e-01 1.27e-01 7.14e-01
Truncations of AMER1 destabilize the destruction complex 14 4.09e-01 1.27e-01 7.14e-01
p75NTR recruits signalling complexes 12 4.45e-01 1.27e-01 7.36e-01
Glucagon signaling in metabolic regulation 26 2.63e-01 1.27e-01 5.96e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 5.61e-01 -1.27e-01 8.30e-01
Nuclear Envelope (NE) Reassembly 68 7.08e-02 1.27e-01 3.33e-01
Chaperone Mediated Autophagy 20 3.27e-01 1.27e-01 6.48e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 4.68e-01 -1.26e-01 7.59e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 4.68e-01 1.26e-01 7.59e-01
DAG and IP3 signaling 34 2.02e-01 -1.26e-01 5.33e-01
Prolactin receptor signaling 12 4.49e-01 -1.26e-01 7.40e-01
Meiotic synapsis 43 1.52e-01 1.26e-01 4.61e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.97e-01 1.26e-01 7.13e-01
Dopamine Neurotransmitter Release Cycle 20 3.31e-01 -1.26e-01 6.50e-01
SUMO is proteolytically processed 6 5.94e-01 -1.26e-01 8.49e-01
Regulation of APC/C activators between G1/S and early anaphase 68 7.38e-02 1.25e-01 3.37e-01
Transport of the SLBP Dependant Mature mRNA 36 1.93e-01 -1.25e-01 5.22e-01
Cargo recognition for clathrin-mediated endocytosis 89 4.24e-02 1.24e-01 2.54e-01
RHOH GTPase cycle 34 2.10e-01 1.24e-01 5.43e-01
Trafficking of GluR2-containing AMPA receptors 11 4.77e-01 1.24e-01 7.67e-01
Negative regulation of NOTCH4 signaling 44 1.56e-01 1.24e-01 4.67e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 2.95e-01 -1.23e-01 6.29e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 2.95e-01 -1.23e-01 6.29e-01
Separation of Sister Chromatids 168 5.77e-03 1.23e-01 8.05e-02
Budding and maturation of HIV virion 26 2.76e-01 1.23e-01 6.07e-01
EML4 and NUDC in mitotic spindle formation 107 2.74e-02 1.23e-01 2.00e-01
Metabolism of water-soluble vitamins and cofactors 115 2.23e-02 -1.23e-01 1.80e-01
Mitochondrial tRNA aminoacylation 21 3.30e-01 -1.23e-01 6.50e-01
Signaling by TGFBR3 39 1.85e-01 -1.23e-01 5.17e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 4.81e-01 1.23e-01 7.71e-01
Ribosomal scanning and start codon recognition 58 1.06e-01 1.23e-01 3.98e-01
GPVI-mediated activation cascade 33 2.24e-01 1.22e-01 5.56e-01
CDK-mediated phosphorylation and removal of Cdc6 60 1.01e-01 1.22e-01 3.94e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 1.04e-01 1.22e-01 3.98e-01
Cellular response to hypoxia 59 1.05e-01 1.22e-01 3.98e-01
G beta:gamma signalling through PI3Kgamma 22 3.23e-01 1.22e-01 6.46e-01
Downstream signaling events of B Cell Receptor (BCR) 68 8.31e-02 1.22e-01 3.56e-01
Asparagine N-linked glycosylation 286 4.06e-04 1.22e-01 1.24e-02
Transport to the Golgi and subsequent modification 171 6.18e-03 1.21e-01 8.27e-02
Translation initiation complex formation 58 1.10e-01 1.21e-01 4.04e-01
G2/M Checkpoints 126 1.87e-02 1.21e-01 1.65e-01
Diseases associated with the TLR signaling cascade 29 2.59e-01 -1.21e-01 5.92e-01
Diseases of Immune System 29 2.59e-01 -1.21e-01 5.92e-01
Transcriptional regulation by RUNX1 170 6.45e-03 1.21e-01 8.37e-02
RAB geranylgeranylation 61 1.02e-01 1.21e-01 3.94e-01
Regulation of lipid metabolism by PPARalpha 107 3.07e-02 -1.21e-01 2.09e-01
Mitotic Anaphase 211 2.48e-03 1.21e-01 4.99e-02
Cytoprotection by HMOX1 53 1.28e-01 1.21e-01 4.25e-01
Dual Incision in GG-NER 41 1.81e-01 -1.21e-01 5.09e-01
Protein lipoylation 10 5.10e-01 -1.20e-01 7.93e-01
Cellular response to chemical stress 179 5.53e-03 1.20e-01 7.99e-02
Downstream signaling of activated FGFR1 22 3.31e-01 1.20e-01 6.50e-01
N-Glycan antennae elongation 13 4.55e-01 1.20e-01 7.49e-01
Termination of translesion DNA synthesis 32 2.42e-01 -1.20e-01 5.78e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 3.67e-01 1.20e-01 6.86e-01
Regulation of TP53 Activity through Acetylation 29 2.66e-01 -1.19e-01 5.99e-01
Triglyceride catabolism 16 4.09e-01 1.19e-01 7.14e-01
Mitotic Metaphase and Anaphase 212 2.76e-03 1.19e-01 5.23e-02
TRAF6 mediated NF-kB activation 23 3.23e-01 -1.19e-01 6.46e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 1.31e-01 1.19e-01 4.30e-01
Diseases of carbohydrate metabolism 29 2.69e-01 1.19e-01 6.04e-01
Synthesis of PIPs at the early endosome membrane 16 4.12e-01 -1.18e-01 7.15e-01
Nicotinamide salvaging 15 4.27e-01 1.18e-01 7.30e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 4.13e-01 -1.18e-01 7.15e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 2.09e-01 1.18e-01 5.42e-01
GABA receptor activation 38 2.11e-01 1.17e-01 5.43e-01
NOTCH2 intracellular domain regulates transcription 11 5.01e-01 -1.17e-01 7.85e-01
Regulation of pyruvate metabolism 32 2.51e-01 1.17e-01 5.87e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 2.84e-01 1.17e-01 6.18e-01
Activation of Ca-permeable Kainate Receptor 9 5.44e-01 1.17e-01 8.19e-01
Ionotropic activity of kainate receptors 9 5.44e-01 1.17e-01 8.19e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.91e-01 1.17e-01 5.19e-01
Kinesins 51 1.50e-01 1.17e-01 4.61e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 5.54e-03 1.16e-01 7.99e-02
RHOBTB3 ATPase cycle 10 5.24e-01 1.16e-01 8.06e-01
Ketone body metabolism 8 5.69e-01 1.16e-01 8.30e-01
TNFR1-induced NF-kappa-B signaling pathway 32 2.56e-01 -1.16e-01 5.90e-01
Glycosphingolipid catabolism 31 2.63e-01 1.16e-01 5.96e-01
Cellular responses to mechanical stimuli 82 7.05e-02 1.16e-01 3.33e-01
Response of endothelial cells to shear stress 82 7.05e-02 1.16e-01 3.33e-01
Activated NTRK3 signals through RAS 7 5.97e-01 1.15e-01 8.51e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 2.32e-01 1.15e-01 5.64e-01
EPHB-mediated forward signaling 40 2.08e-01 1.15e-01 5.42e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 1.60e-01 1.15e-01 4.77e-01
Degradation of AXIN 42 1.98e-01 1.15e-01 5.27e-01
Adipogenesis 96 5.20e-02 -1.15e-01 2.89e-01
Negative regulation of FLT3 15 4.42e-01 -1.15e-01 7.36e-01
Signaling by FLT3 ITD and TKD mutants 15 4.43e-01 1.14e-01 7.36e-01
Potential therapeutics for SARS 149 1.61e-02 1.14e-01 1.51e-01
Vpu mediated degradation of CD4 39 2.17e-01 1.14e-01 5.51e-01
Purine catabolism 16 4.29e-01 1.14e-01 7.31e-01
MAP kinase activation 63 1.18e-01 1.14e-01 4.12e-01
CaM pathway 28 2.97e-01 -1.14e-01 6.30e-01
Calmodulin induced events 28 2.97e-01 -1.14e-01 6.30e-01
Platelet sensitization by LDL 16 4.32e-01 1.13e-01 7.31e-01
Diseases associated with glycosaminoglycan metabolism 25 3.27e-01 1.13e-01 6.48e-01
Evasion by RSV of host interferon responses 20 3.82e-01 -1.13e-01 7.03e-01
SUMOylation of RNA binding proteins 47 1.81e-01 -1.13e-01 5.08e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 1.28e-01 1.13e-01 4.25e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 4.09e-01 -1.13e-01 7.14e-01
Cell junction organization 82 7.85e-02 -1.12e-01 3.50e-01
Axon guidance 459 3.94e-05 1.12e-01 1.65e-03
Translesion synthesis by REV1 16 4.40e-01 -1.12e-01 7.36e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 5.85e-01 1.11e-01 8.46e-01
rRNA processing 213 5.12e-03 1.11e-01 7.61e-02
Interleukin-37 signaling 19 4.01e-01 1.11e-01 7.14e-01
Sodium-coupled phosphate cotransporters 5 6.67e-01 -1.11e-01 8.82e-01
Hyaluronan uptake and degradation 12 5.06e-01 1.11e-01 7.90e-01
Nephron development 5 6.68e-01 -1.11e-01 8.82e-01
Retrograde neurotrophin signalling 12 5.06e-01 1.11e-01 7.90e-01
MECP2 regulates transcription factors 5 6.68e-01 -1.11e-01 8.82e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 5.45e-01 -1.11e-01 8.20e-01
Fanconi Anemia Pathway 36 2.52e-01 -1.10e-01 5.87e-01
ER to Golgi Anterograde Transport 145 2.18e-02 1.10e-01 1.79e-01
Activated point mutants of FGFR2 7 6.13e-01 -1.10e-01 8.56e-01
Gap junction degradation 11 5.28e-01 1.10e-01 8.06e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 3.23e-01 1.10e-01 6.46e-01
Defective GALNT3 causes HFTC 9 5.68e-01 -1.10e-01 8.30e-01
Regulation of TP53 Expression and Degradation 36 2.55e-01 1.10e-01 5.90e-01
Positive epigenetic regulation of rRNA expression 60 1.42e-01 1.10e-01 4.49e-01
Interleukin-1 family signaling 127 3.30e-02 1.10e-01 2.18e-01
Stabilization of p53 43 2.15e-01 1.09e-01 5.49e-01
Diseases associated with glycosylation precursor biosynthesis 15 4.64e-01 1.09e-01 7.57e-01
G beta:gamma signalling through CDC42 17 4.36e-01 1.09e-01 7.35e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.87e-01 1.09e-01 7.08e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.87e-01 1.09e-01 7.08e-01
RHOB GTPase cycle 65 1.29e-01 1.09e-01 4.25e-01
Cell Cycle Checkpoints 246 3.24e-03 1.09e-01 5.91e-02
Downregulation of TGF-beta receptor signaling 26 3.36e-01 1.09e-01 6.52e-01
Metalloprotease DUBs 20 3.99e-01 1.09e-01 7.14e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 3.48e-01 1.09e-01 6.66e-01
PPARA activates gene expression 105 5.57e-02 -1.08e-01 2.98e-01
RNA Polymerase I Transcription Initiation 47 2.01e-01 -1.08e-01 5.31e-01
Signaling by FGFR1 42 2.27e-01 1.08e-01 5.59e-01
Fatty acyl-CoA biosynthesis 35 2.70e-01 1.08e-01 6.04e-01
G2/M DNA damage checkpoint 66 1.31e-01 1.07e-01 4.30e-01
DAP12 interactions 39 2.46e-01 1.07e-01 5.82e-01
Triglyceride metabolism 26 3.44e-01 1.07e-01 6.63e-01
Interleukin-6 signaling 11 5.38e-01 -1.07e-01 8.14e-01
Apoptosis 158 2.03e-02 1.07e-01 1.75e-01
Activation of kainate receptors upon glutamate binding 26 3.45e-01 1.07e-01 6.65e-01
CLEC7A (Dectin-1) induces NFAT activation 11 5.40e-01 -1.07e-01 8.16e-01
FGFR2 alternative splicing 25 3.57e-01 1.06e-01 6.76e-01
Calcineurin activates NFAT 9 5.81e-01 1.06e-01 8.43e-01
Signaling by KIT in disease 20 4.11e-01 -1.06e-01 7.15e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 4.11e-01 -1.06e-01 7.15e-01
ABC transporters in lipid homeostasis 14 4.92e-01 -1.06e-01 7.76e-01
Antigen processing-Cross presentation 89 8.36e-02 1.06e-01 3.56e-01
G1/S DNA Damage Checkpoints 54 1.78e-01 1.06e-01 5.05e-01
Signaling by NOTCH3 44 2.26e-01 1.05e-01 5.59e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 8.26e-02 1.05e-01 3.56e-01
Amplification of signal from the kinetochores 91 8.26e-02 1.05e-01 3.56e-01
Activation of BH3-only proteins 30 3.19e-01 1.05e-01 6.45e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.90e-01 1.05e-01 5.19e-01
tRNA modification in the nucleus and cytosol 43 2.34e-01 -1.05e-01 5.67e-01
RORA activates gene expression 18 4.41e-01 -1.05e-01 7.36e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.13e-01 1.05e-01 6.38e-01
Collagen degradation 44 2.31e-01 1.04e-01 5.64e-01
Activation of Matrix Metalloproteinases 22 3.96e-01 1.04e-01 7.13e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 4.43e-01 -1.04e-01 7.36e-01
Protein hydroxylation 17 4.57e-01 1.04e-01 7.49e-01
Suppression of phagosomal maturation 12 5.32e-01 1.04e-01 8.10e-01
Formation of WDR5-containing histone-modifying complexes 42 2.43e-01 -1.04e-01 5.80e-01
HDR through Single Strand Annealing (SSA) 37 2.74e-01 -1.04e-01 6.07e-01
Glutamate and glutamine metabolism 12 5.33e-01 1.04e-01 8.10e-01
Ca-dependent events 30 3.25e-01 -1.04e-01 6.47e-01
Intrinsic Pathway for Apoptosis 54 1.88e-01 1.03e-01 5.18e-01
Mitochondrial iron-sulfur cluster biogenesis 13 5.21e-01 -1.03e-01 8.04e-01
Somitogenesis 41 2.56e-01 1.03e-01 5.90e-01
Signaling by PDGF 50 2.10e-01 1.02e-01 5.43e-01
NoRC negatively regulates rRNA expression 60 1.70e-01 1.02e-01 4.92e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 3.32e-01 1.02e-01 6.50e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 4.65e-01 -1.02e-01 7.57e-01
Inositol phosphate metabolism 42 2.53e-01 -1.02e-01 5.87e-01
MECP2 regulates neuronal receptors and channels 14 5.10e-01 -1.02e-01 7.93e-01
G beta:gamma signalling through PLC beta 17 4.69e-01 1.02e-01 7.59e-01
Presynaptic function of Kainate receptors 17 4.69e-01 1.02e-01 7.59e-01
Post-translational modification: synthesis of GPI-anchored proteins 59 1.77e-01 -1.02e-01 5.05e-01
Degradation of cysteine and homocysteine 13 5.27e-01 -1.01e-01 8.06e-01
Glycine degradation 7 6.43e-01 1.01e-01 8.75e-01
Mitochondrial protein degradation 96 8.65e-02 1.01e-01 3.67e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.69e-01 -1.01e-01 4.91e-01
SCF(Skp2)-mediated degradation of p27/p21 50 2.17e-01 1.01e-01 5.51e-01
Transcriptional regulation of pluripotent stem cells 21 4.24e-01 1.01e-01 7.30e-01
Aspirin ADME 16 4.86e-01 1.01e-01 7.73e-01
TGF-beta receptor signaling activates SMADs 45 2.44e-01 1.00e-01 5.80e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 1.24e-01 1.00e-01 4.19e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 5.17e-01 1.00e-01 8.01e-01
Orc1 removal from chromatin 58 1.88e-01 1.00e-01 5.18e-01
Diseases associated with O-glycosylation of proteins 50 2.22e-01 -9.99e-02 5.55e-01
Defective Intrinsic Pathway for Apoptosis 24 3.97e-01 9.98e-02 7.13e-01
Transcriptional regulation by RUNX3 81 1.20e-01 9.98e-02 4.15e-01
SUMOylation of transcription factors 16 4.90e-01 -9.98e-02 7.76e-01
Translation of Structural Proteins 9683701 29 3.53e-01 9.96e-02 6.73e-01
Signaling by FGFR3 in disease 14 5.19e-01 9.96e-02 8.03e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 5.68e-01 -9.95e-02 8.30e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 5.21e-01 -9.91e-02 8.04e-01
Translesion synthesis by POLK 17 4.79e-01 -9.91e-02 7.71e-01
Regulation of HMOX1 expression and activity 5 7.02e-01 -9.89e-02 8.95e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 5.38e-01 9.87e-02 8.14e-01
Innate Immune System 971 1.90e-07 9.87e-02 1.37e-05
Role of ABL in ROBO-SLIT signaling 6 6.76e-01 9.84e-02 8.88e-01
Translesion synthesis by POLI 17 4.83e-01 -9.83e-02 7.71e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 2.95e-01 9.82e-02 6.29e-01
Synthesis of diphthamide-EEF2 8 6.31e-01 9.80e-02 8.69e-01
Degradation of beta-catenin by the destruction complex 72 1.51e-01 9.78e-02 4.61e-01
Formation of paraxial mesoderm 52 2.23e-01 9.77e-02 5.56e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 5.29e-01 9.72e-02 8.06e-01
FGFR1b ligand binding and activation 5 7.07e-01 9.72e-02 8.98e-01
Lysosome Vesicle Biogenesis 32 3.41e-01 9.72e-02 6.60e-01
Interleukin-17 signaling 68 1.66e-01 9.71e-02 4.88e-01
DNA Damage Bypass 47 2.50e-01 -9.71e-02 5.86e-01
Gain-of-function MRAS complexes activate RAF signaling 8 6.35e-01 -9.70e-02 8.71e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 6.35e-01 -9.70e-02 8.71e-01
Signaling by MRAS-complex mutants 8 6.35e-01 -9.70e-02 8.71e-01
FGFR1 ligand binding and activation 10 5.95e-01 9.70e-02 8.49e-01
Signaling by BRAF and RAF1 fusions 60 1.94e-01 9.70e-02 5.22e-01
Synthesis of Dolichyl-phosphate 6 6.82e-01 9.67e-02 8.89e-01
Membrane Trafficking 577 7.34e-05 9.66e-02 2.89e-03
Sensory Perception 197 1.98e-02 9.63e-02 1.72e-01
Nervous system development 478 3.17e-04 9.61e-02 1.01e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 4.94e-01 -9.59e-02 7.77e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 4.94e-01 -9.59e-02 7.77e-01
HCMV Late Events 67 1.75e-01 9.57e-02 5.04e-01
Complex IV assembly 45 2.67e-01 9.57e-02 6.00e-01
Extra-nuclear estrogen signaling 67 1.78e-01 9.52e-02 5.05e-01
Recognition of DNA damage by PCNA-containing replication complex 30 3.68e-01 -9.50e-02 6.87e-01
SHC-mediated cascade:FGFR3 10 6.03e-01 9.49e-02 8.51e-01
Regulation of RUNX2 expression and activity 54 2.28e-01 9.49e-02 5.59e-01
mTORC1-mediated signalling 24 4.22e-01 9.47e-02 7.27e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 5.87e-01 9.46e-02 8.47e-01
Negative epigenetic regulation of rRNA expression 63 1.95e-01 9.43e-02 5.25e-01
ERKs are inactivated 13 5.56e-01 9.43e-02 8.26e-01
Mitotic Spindle Checkpoint 108 9.07e-02 9.42e-02 3.75e-01
Blood group systems biosynthesis 18 4.89e-01 9.42e-02 7.76e-01
Ion transport by P-type ATPases 43 2.85e-01 -9.42e-02 6.19e-01
p75NTR signals via NF-kB 15 5.28e-01 9.40e-02 8.06e-01
UCH proteinases 73 1.65e-01 9.40e-02 4.87e-01
Signaling by TGF-beta Receptor Complex 91 1.23e-01 9.35e-02 4.19e-01
cGMP effects 12 5.75e-01 9.35e-02 8.35e-01
GDP-fucose biosynthesis 6 6.92e-01 -9.34e-02 8.91e-01
Glycosphingolipid metabolism 46 2.73e-01 9.34e-02 6.07e-01
Pre-NOTCH Expression and Processing 63 2.00e-01 9.33e-02 5.31e-01
TP53 Regulates Transcription of Cell Death Genes 43 2.91e-01 -9.30e-02 6.26e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 2.11e-01 -9.27e-02 5.43e-01
Hydrolysis of LPC 8 6.50e-01 9.25e-02 8.79e-01
Phase II - Conjugation of compounds 71 1.79e-01 9.23e-02 5.05e-01
Assembly Of The HIV Virion 15 5.36e-01 9.23e-02 8.12e-01
Impaired BRCA2 binding to RAD51 35 3.47e-01 -9.19e-02 6.66e-01
TRP channels 22 4.58e-01 -9.15e-02 7.49e-01
Methylation 13 5.68e-01 9.14e-02 8.30e-01
Mitochondrial translation initiation 90 1.36e-01 9.09e-02 4.38e-01
Purine ribonucleoside monophosphate biosynthesis 9 6.37e-01 -9.08e-02 8.72e-01
Interleukin-1 signaling 99 1.19e-01 9.07e-02 4.13e-01
p53-Dependent G1 DNA Damage Response 52 2.59e-01 9.06e-02 5.92e-01
p53-Dependent G1/S DNA damage checkpoint 52 2.59e-01 9.06e-02 5.92e-01
SUMOylation of ubiquitinylation proteins 39 3.29e-01 -9.04e-02 6.49e-01
Heparan sulfate/heparin (HS-GAG) metabolism 40 3.23e-01 9.04e-02 6.46e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.64e-01 9.00e-02 6.83e-01
Beta-oxidation of very long chain fatty acids 11 6.05e-01 9.00e-02 8.52e-01
Activation of HOX genes during differentiation 70 1.93e-01 9.00e-02 5.22e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 1.93e-01 9.00e-02 5.22e-01
Mitochondrial translation termination 90 1.40e-01 9.00e-02 4.46e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 6.22e-01 -9.00e-02 8.62e-01
Protein methylation 15 5.46e-01 9.00e-02 8.21e-01
Mitochondrial translation elongation 90 1.40e-01 8.99e-02 4.46e-01
Thyroxine biosynthesis 5 7.28e-01 -8.98e-02 9.15e-01
NRAGE signals death through JNK 52 2.63e-01 -8.98e-02 5.96e-01
Ub-specific processing proteases 153 5.63e-02 8.94e-02 2.98e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 6.42e-01 -8.94e-02 8.75e-01
Inhibition of Signaling by Overexpressed EGFR 6 7.05e-01 8.93e-02 8.97e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 7.05e-01 8.93e-02 8.97e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 1.09e-01 -8.92e-02 4.04e-01
Attachment and Entry 9694614 14 5.63e-01 -8.92e-02 8.30e-01
Signaling by WNT in cancer 30 3.98e-01 8.92e-02 7.14e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 6.63e-01 -8.91e-02 8.82e-01
Pyroptosis 25 4.41e-01 -8.90e-02 7.36e-01
Diseases of programmed cell death 58 2.42e-01 8.88e-02 5.78e-01
Transcriptional regulation of white adipocyte differentiation 77 1.79e-01 -8.85e-02 5.05e-01
tRNA processing in the nucleus 59 2.40e-01 -8.85e-02 5.76e-01
Phosphorylation of Emi1 6 7.08e-01 8.83e-02 8.99e-01
Programmed Cell Death 187 3.75e-02 8.82e-02 2.37e-01
Activation of gene expression by SREBF (SREBP) 42 3.23e-01 -8.81e-02 6.46e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.09e-01 8.81e-02 4.04e-01
Class B/2 (Secretin family receptors) 55 2.60e-01 -8.79e-02 5.92e-01
Pre-NOTCH Transcription and Translation 47 2.97e-01 8.79e-02 6.30e-01
PI Metabolism 79 1.77e-01 -8.78e-02 5.05e-01
Signaling by RNF43 mutants 7 6.88e-01 8.77e-02 8.90e-01
Triglyceride biosynthesis 10 6.31e-01 8.77e-02 8.69e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.88e-01 -8.73e-02 5.18e-01
Cyclin E associated events during G1/S transition 73 1.98e-01 8.71e-02 5.27e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 7.36e-01 8.70e-02 9.17e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 4.43e-01 -8.69e-02 7.36e-01
SMAC (DIABLO) binds to IAPs 7 6.91e-01 -8.69e-02 8.90e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 6.91e-01 -8.69e-02 8.90e-01
SMAC, XIAP-regulated apoptotic response 7 6.91e-01 -8.69e-02 8.90e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 5.36e-01 8.68e-02 8.12e-01
Meiosis 67 2.20e-01 8.66e-02 5.54e-01
RHO GTPases Activate Formins 128 9.08e-02 8.66e-02 3.75e-01
SUMOylation of immune response proteins 12 6.04e-01 -8.64e-02 8.52e-01
Transcriptional Regulation by MECP2 49 2.96e-01 -8.62e-02 6.30e-01
DAP12 signaling 28 4.30e-01 8.61e-02 7.31e-01
Iron uptake and transport 52 2.84e-01 8.58e-02 6.18e-01
Unwinding of DNA 12 6.08e-01 -8.55e-02 8.52e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 5.69e-01 -8.50e-02 8.30e-01
Regulation of TP53 Degradation 35 3.86e-01 8.47e-02 7.07e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 3.43e-01 -8.46e-02 6.60e-01
Visual phototransduction 60 2.57e-01 8.46e-02 5.91e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 6.13e-01 8.44e-02 8.56e-01
Gamma-carboxylation of protein precursors 6 7.21e-01 -8.43e-02 9.11e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 4.32e-01 8.43e-02 7.31e-01
ADP signalling through P2Y purinoceptor 1 21 5.05e-01 8.40e-02 7.90e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 4.50e-01 8.40e-02 7.42e-01
Mitochondrial translation 96 1.56e-01 8.38e-02 4.66e-01
PIWI-interacting RNA (piRNA) biogenesis 23 4.86e-01 -8.38e-02 7.74e-01
Late endosomal microautophagy 30 4.27e-01 8.38e-02 7.30e-01
RNA Polymerase I Promoter Clearance 64 2.47e-01 8.37e-02 5.82e-01
RNA Polymerase I Transcription 64 2.47e-01 8.37e-02 5.82e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.28e-01 8.37e-02 7.30e-01
Regulation of KIT signaling 15 5.75e-01 -8.37e-02 8.35e-01
Beta-catenin independent WNT signaling 126 1.05e-01 8.36e-02 3.98e-01
PI-3K cascade:FGFR2 13 6.02e-01 8.35e-02 8.51e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 6.17e-01 8.34e-02 8.59e-01
Transcriptional regulation of testis differentiation 5 7.48e-01 -8.30e-02 9.20e-01
RSV-host interactions 78 2.07e-01 -8.26e-02 5.42e-01
Signaling by NTRK3 (TRKC) 16 5.69e-01 -8.23e-02 8.30e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 4.38e-01 -8.18e-02 7.36e-01
Respiratory syncytial virus (RSV) attachment and entry 18 5.48e-01 8.18e-02 8.22e-01
Nephrin family interactions 20 5.27e-01 8.18e-02 8.06e-01
Activation of GABAB receptors 31 4.31e-01 8.17e-02 7.31e-01
GABA B receptor activation 31 4.31e-01 8.17e-02 7.31e-01
HCMV Infection 106 1.46e-01 8.17e-02 4.56e-01
RHOC GTPase cycle 72 2.32e-01 8.15e-02 5.64e-01
Cytochrome c-mediated apoptotic response 13 6.13e-01 8.11e-02 8.56e-01
Metabolism of vitamins and cofactors 166 7.18e-02 -8.10e-02 3.36e-01
Dual incision in TC-NER 63 2.67e-01 -8.09e-02 6.00e-01
Organelle biogenesis and maintenance 277 2.06e-02 -8.09e-02 1.76e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 3.23e-01 8.08e-02 6.46e-01
MyD88 deficiency (TLR2/4) 14 6.01e-01 -8.07e-02 8.51e-01
Cellular responses to stimuli 779 1.32e-04 8.05e-02 4.76e-03
PI3K Cascade 31 4.40e-01 8.01e-02 7.36e-01
Peroxisomal lipid metabolism 27 4.72e-01 -8.01e-02 7.62e-01
VxPx cargo-targeting to cilium 19 5.46e-01 8.00e-02 8.21e-01
Arachidonate metabolism 45 3.53e-01 7.99e-02 6.73e-01
Regulation of innate immune responses to cytosolic DNA 14 6.05e-01 -7.98e-02 8.52e-01
Nef Mediated CD4 Down-regulation 9 6.79e-01 7.98e-02 8.88e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 5.18e-01 7.96e-02 8.03e-01
Signaling by Activin 14 6.06e-01 7.96e-02 8.52e-01
Mitochondrial protein import 63 2.75e-01 7.95e-02 6.07e-01
Bacterial Infection Pathways 66 2.66e-01 7.92e-02 5.99e-01
Cellular response to starvation 148 9.74e-02 7.89e-02 3.87e-01
Beta-oxidation of pristanoyl-CoA 9 6.82e-01 -7.88e-02 8.89e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 3.73e-01 -7.85e-02 6.93e-01
Metabolism of porphyrins 23 5.15e-01 -7.84e-02 8.00e-01
Voltage gated Potassium channels 26 4.89e-01 -7.83e-02 7.76e-01
FLT3 signaling in disease 27 4.81e-01 -7.83e-02 7.71e-01
Anchoring of the basal body to the plasma membrane 97 1.84e-01 -7.80e-02 5.15e-01
Regulation of PTEN mRNA translation 13 6.26e-01 -7.80e-02 8.63e-01
Scavenging by Class F Receptors 5 7.64e-01 -7.74e-02 9.20e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 1.13e-01 7.73e-02 4.06e-01
Metal ion SLC transporters 19 5.61e-01 7.70e-02 8.30e-01
Chromosome Maintenance 103 1.77e-01 7.70e-02 5.05e-01
Tight junction interactions 17 5.83e-01 -7.70e-02 8.44e-01
Reduction of cytosolic Ca++ levels 9 6.89e-01 7.69e-02 8.90e-01
RHOF GTPase cycle 39 4.07e-01 7.68e-02 7.14e-01
Signaling by LTK in cancer 7 7.26e-01 7.64e-02 9.14e-01
Nuclear Events (kinase and transcription factor activation) 54 3.32e-01 -7.63e-02 6.50e-01
Activated NTRK3 signals through PI3K 5 7.68e-01 7.62e-02 9.20e-01
MAPK6/MAPK4 signaling 69 2.74e-01 7.61e-02 6.07e-01
Interferon Signaling 240 4.23e-02 -7.61e-02 2.54e-01
Formation of annular gap junctions 10 6.77e-01 7.60e-02 8.88e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 6.78e-01 7.57e-02 8.88e-01
Defective EXT2 causes exostoses 2 10 6.78e-01 7.57e-02 8.88e-01
VEGFA-VEGFR2 Pathway 93 2.07e-01 7.57e-02 5.42e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 2.25e-01 7.56e-02 5.59e-01
Downregulation of ERBB2:ERBB3 signaling 12 6.50e-01 -7.56e-02 8.79e-01
Platelet homeostasis 69 2.80e-01 7.52e-02 6.13e-01
Cellular response to heat stress 94 2.08e-01 -7.52e-02 5.42e-01
N-glycan trimming and elongation in the cis-Golgi 5 7.71e-01 7.51e-02 9.20e-01
Transport of nucleotide sugars 9 6.98e-01 7.48e-02 8.92e-01
RHO GTPases activate KTN1 11 6.68e-01 7.47e-02 8.82e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 3.81e-01 -7.46e-02 7.03e-01
Glyoxylate metabolism and glycine degradation 13 6.42e-01 7.45e-02 8.75e-01
RA biosynthesis pathway 13 6.42e-01 -7.45e-02 8.75e-01
Translation 293 2.86e-02 7.43e-02 2.01e-01
Deadenylation of mRNA 22 5.47e-01 7.42e-02 8.21e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 7.53e-01 -7.42e-02 9.20e-01
Termination of O-glycan biosynthesis 16 6.08e-01 -7.41e-02 8.52e-01
RAF activation 33 4.63e-01 7.39e-02 7.55e-01
Proteasome assembly 50 3.67e-01 7.37e-02 6.86e-01
Degradation of the extracellular matrix 99 2.05e-01 7.37e-02 5.39e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 5.00e-01 7.36e-02 7.84e-01
M Phase 346 1.86e-02 7.36e-02 1.65e-01
RHOD GTPase cycle 50 3.68e-01 7.36e-02 6.87e-01
Release of apoptotic factors from the mitochondria 6 7.55e-01 -7.35e-02 9.20e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 6.22e-01 7.35e-02 8.62e-01
RAB GEFs exchange GTP for GDP on RABs 89 2.31e-01 7.34e-02 5.64e-01
Post-translational protein phosphorylation 70 2.91e-01 7.29e-02 6.26e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.48e-01 -7.29e-02 5.83e-01
Ephrin signaling 18 5.92e-01 -7.29e-02 8.49e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 7.38e-01 -7.29e-02 9.18e-01
Signaling by WNT 241 5.15e-02 7.28e-02 2.89e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.69e-01 7.27e-02 6.87e-01
Negative regulation of the PI3K/AKT network 93 2.28e-01 7.24e-02 5.59e-01
DNA replication initiation 8 7.24e-01 -7.22e-02 9.13e-01
Telomere Maintenance 78 2.71e-01 7.21e-02 6.04e-01
Nonhomologous End-Joining (NHEJ) 40 4.30e-01 7.21e-02 7.31e-01
Interleukin-12 family signaling 53 3.64e-01 7.20e-02 6.84e-01
Insulin processing 19 5.87e-01 -7.19e-02 8.47e-01
RUNX3 regulates CDKN1A transcription 7 7.42e-01 -7.18e-02 9.18e-01
Cohesin Loading onto Chromatin 10 6.95e-01 -7.16e-02 8.92e-01
Cell-Cell communication 114 1.87e-01 -7.15e-02 5.18e-01
Formation of the beta-catenin:TCF transactivating complex 44 4.14e-01 7.12e-02 7.16e-01
Signaling by Leptin 10 6.97e-01 7.10e-02 8.92e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 5.64e-01 7.10e-02 8.30e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 4.37e-01 -7.10e-02 7.36e-01
Diseases associated with N-glycosylation of proteins 20 5.83e-01 7.10e-02 8.44e-01
TNF signaling 56 3.58e-01 -7.09e-02 6.78e-01
Generic Transcription Pathway 1088 8.38e-05 -7.06e-02 3.24e-03
WNT ligand biogenesis and trafficking 19 5.95e-01 -7.05e-02 8.49e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.28e-01 7.02e-02 8.06e-01
Gastrulation 76 2.91e-01 7.01e-02 6.26e-01
Switching of origins to a post-replicative state 79 2.82e-01 7.01e-02 6.16e-01
Circadian Clock 67 3.22e-01 -7.00e-02 6.46e-01
Diseases of Mismatch Repair (MMR) 5 7.87e-01 6.96e-02 9.24e-01
Adaptive Immune System 768 1.06e-03 6.94e-02 2.76e-02
Cellular responses to stress 698 1.81e-03 6.93e-02 3.98e-02
Signaling by NTRK2 (TRKB) 20 5.92e-01 6.92e-02 8.49e-01
Signaling by ERBB2 KD Mutants 20 5.92e-01 -6.92e-02 8.49e-01
Downstream signaling of activated FGFR4 18 6.12e-01 6.91e-02 8.56e-01
Nucleotide catabolism 28 5.27e-01 6.91e-02 8.06e-01
Keratan sulfate biosynthesis 20 5.94e-01 -6.89e-02 8.49e-01
rRNA processing in the nucleus and cytosol 189 1.03e-01 6.88e-02 3.94e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 3.13e-01 -6.87e-02 6.38e-01
Small interfering RNA (siRNA) biogenesis 9 7.21e-01 6.87e-02 9.11e-01
Regulation of HSF1-mediated heat shock response 79 2.93e-01 -6.84e-02 6.28e-01
NIK–>noncanonical NF-kB signaling 46 4.22e-01 6.84e-02 7.27e-01
HDR through Homologous Recombination (HRR) 68 3.30e-01 -6.83e-02 6.50e-01
IRS-mediated signalling 35 4.85e-01 6.83e-02 7.72e-01
PTK6 promotes HIF1A stabilization 6 7.73e-01 6.81e-02 9.21e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 6.08e-01 6.80e-02 8.52e-01
Sialic acid metabolism 28 5.35e-01 -6.78e-02 8.12e-01
Mitotic Prophase 96 2.51e-01 6.78e-02 5.87e-01
Negative regulation of MAPK pathway 42 4.47e-01 6.77e-02 7.39e-01
DNA Replication 128 1.87e-01 6.76e-02 5.18e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.98e-01 6.75e-02 8.92e-01
Cyclin A:Cdk2-associated events at S phase entry 75 3.12e-01 6.75e-02 6.38e-01
E2F-enabled inhibition of pre-replication complex formation 9 7.26e-01 6.74e-02 9.14e-01
Nucleotide-like (purinergic) receptors 13 6.74e-01 -6.74e-02 8.87e-01
Base Excision Repair 57 3.79e-01 -6.73e-02 7.01e-01
FGFR1c ligand binding and activation 8 7.42e-01 6.73e-02 9.18e-01
Sensory processing of sound by inner hair cells of the cochlea 54 3.92e-01 -6.73e-02 7.13e-01
Acetylcholine binding and downstream events 5 7.95e-01 6.72e-02 9.25e-01
Postsynaptic nicotinic acetylcholine receptors 5 7.95e-01 6.72e-02 9.25e-01
Extension of Telomeres 51 4.06e-01 -6.72e-02 7.14e-01
Biosynthesis of DHA-derived SPMs 15 6.53e-01 -6.71e-02 8.80e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 6.89e-01 -6.68e-02 8.90e-01
alpha-linolenic acid (ALA) metabolism 12 6.89e-01 -6.68e-02 8.90e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 3.14e-01 6.68e-02 6.39e-01
Signaling by FGFR 73 3.24e-01 6.67e-02 6.47e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 1.24e-01 6.66e-02 4.19e-01
tRNA Aminoacylation 42 4.58e-01 -6.61e-02 7.49e-01
RUNX3 regulates WNT signaling 8 7.47e-01 -6.60e-02 9.19e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 6.19e-01 -6.59e-02 8.61e-01
Sulfur amino acid metabolism 23 5.84e-01 -6.59e-02 8.45e-01
tRNA modification in the mitochondrion 9 7.32e-01 6.58e-02 9.17e-01
Glucose metabolism 76 3.23e-01 -6.56e-02 6.46e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 5.16e-03 6.56e-02 7.61e-02
Zinc transporters 12 6.94e-01 6.55e-02 8.92e-01
Oxidative Stress Induced Senescence 77 3.21e-01 6.55e-02 6.46e-01
HCMV Early Events 84 3.00e-01 6.54e-02 6.33e-01
FasL/ CD95L signaling 5 8.00e-01 6.54e-02 9.27e-01
Paracetamol ADME 19 6.22e-01 -6.54e-02 8.62e-01
RNA Polymerase II Transcription 1206 1.33e-04 -6.53e-02 4.76e-03
Endogenous sterols 18 6.32e-01 -6.52e-02 8.69e-01
Deubiquitination 225 9.21e-02 6.52e-02 3.77e-01
SHC1 events in EGFR signaling 12 6.96e-01 6.52e-02 8.92e-01
Signaling by Non-Receptor Tyrosine Kinases 47 4.40e-01 6.51e-02 7.36e-01
Signaling by PTK6 47 4.40e-01 6.51e-02 7.36e-01
Centrosome maturation 81 3.11e-01 -6.51e-02 6.37e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.11e-01 -6.51e-02 6.37e-01
Extracellular matrix organization 222 9.46e-02 6.51e-02 3.83e-01
Class I MHC mediated antigen processing & presentation 344 3.83e-02 6.50e-02 2.39e-01
FOXO-mediated transcription 58 3.92e-01 6.50e-02 7.13e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.85e-01 -6.49e-02 8.90e-01
Signaling by Receptor Tyrosine Kinases 449 1.85e-02 6.49e-02 1.64e-01
IRAK4 deficiency (TLR2/4) 15 6.64e-01 -6.48e-02 8.82e-01
Processing of Intronless Pre-mRNAs 20 6.17e-01 6.46e-02 8.59e-01
LDL clearance 18 6.35e-01 6.46e-02 8.71e-01
TCF dependent signaling in response to WNT 153 1.68e-01 6.45e-02 4.91e-01
CDC6 association with the ORC:origin complex 8 7.52e-01 -6.44e-02 9.20e-01
Nucleotide Excision Repair 108 2.47e-01 -6.44e-02 5.82e-01
RHOBTB2 GTPase cycle 23 5.93e-01 6.44e-02 8.49e-01
Activation of RAS in B cells 5 8.03e-01 -6.44e-02 9.29e-01
FLT3 signaling by CBL mutants 7 7.69e-01 6.42e-02 9.20e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 6.68e-01 -6.41e-02 8.82e-01
DNA Repair 289 6.17e-02 -6.39e-02 3.16e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 7.41e-01 6.37e-02 9.18e-01
PKA activation 15 6.69e-01 6.37e-02 8.82e-01
SLC transporter disorders 77 3.36e-01 -6.35e-02 6.51e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 4.83e-01 -6.34e-02 7.71e-01
Diseases of DNA Double-Strand Break Repair 41 4.83e-01 -6.34e-02 7.71e-01
Complex III assembly 23 6.00e-01 6.32e-02 8.51e-01
Peroxisomal protein import 58 4.05e-01 -6.32e-02 7.14e-01
GRB2 events in EGFR signaling 11 7.17e-01 6.31e-02 9.08e-01
Postmitotic nuclear pore complex (NPC) reformation 27 5.72e-01 -6.28e-02 8.34e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 6.45e-01 6.28e-02 8.75e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 6.45e-01 6.28e-02 8.75e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 5.59e-01 -6.28e-02 8.28e-01
SLBP independent Processing of Histone Pre-mRNAs 10 7.32e-01 -6.27e-02 9.17e-01
Processing of DNA double-strand break ends 69 3.69e-01 6.25e-02 6.87e-01
CD28 dependent PI3K/Akt signaling 22 6.12e-01 -6.25e-02 8.56e-01
Transcriptional activation of mitochondrial biogenesis 52 4.36e-01 -6.24e-02 7.35e-01
MAPK1/MAPK3 signaling 232 1.02e-01 6.24e-02 3.94e-01
Glutathione conjugation 28 5.68e-01 -6.23e-02 8.30e-01
Signaling by Erythropoietin 24 5.98e-01 -6.22e-02 8.51e-01
FRS-mediated FGFR4 signaling 13 6.98e-01 6.21e-02 8.92e-01
Homologous DNA Pairing and Strand Exchange 43 4.81e-01 -6.21e-02 7.71e-01
Carboxyterminal post-translational modifications of tubulin 34 5.33e-01 6.18e-02 8.10e-01
RAF/MAP kinase cascade 226 1.11e-01 6.16e-02 4.04e-01
Gene expression (Transcription) 1413 1.06e-04 -6.15e-02 3.93e-03
Serine biosynthesis 8 7.65e-01 6.11e-02 9.20e-01
Signaling by ERBB2 ECD mutants 15 6.82e-01 6.10e-02 8.89e-01
CaMK IV-mediated phosphorylation of CREB 9 7.51e-01 -6.10e-02 9.20e-01
Diseases of DNA repair 51 4.51e-01 -6.10e-02 7.43e-01
Cell recruitment (pro-inflammatory response) 25 5.99e-01 -6.08e-02 8.51e-01
Purinergic signaling in leishmaniasis infection 25 5.99e-01 -6.08e-02 8.51e-01
Biosynthesis of maresins 7 7.81e-01 -6.08e-02 9.24e-01
Metabolism of steroid hormones 22 6.25e-01 6.03e-02 8.63e-01
PKR-mediated signaling 67 3.96e-01 6.00e-02 7.13e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 4.00e-01 -5.99e-02 7.14e-01
Glycosaminoglycan metabolism 98 3.06e-01 5.99e-02 6.33e-01
Infectious disease 959 1.71e-03 5.98e-02 3.80e-02
STING mediated induction of host immune responses 15 6.89e-01 -5.98e-02 8.90e-01
Biosynthesis of maresin-like SPMs 5 8.17e-01 -5.97e-02 9.40e-01
SARS-CoV-2-host interactions 183 1.64e-01 -5.96e-02 4.86e-01
Signaling by Rho GTPases 608 1.22e-02 5.95e-02 1.26e-01
Respiratory electron transport 149 2.10e-01 5.95e-02 5.43e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 5.94e-01 5.93e-02 8.49e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 6.17e-01 -5.91e-02 8.59e-01
Nuclear signaling by ERBB4 24 6.17e-01 -5.89e-02 8.59e-01
Death Receptor Signaling 145 2.22e-01 -5.88e-02 5.55e-01
RNA Polymerase III Transcription Initiation 36 5.43e-01 5.86e-02 8.19e-01
Lysine catabolism 11 7.37e-01 -5.85e-02 9.17e-01
Dectin-2 family 19 6.59e-01 5.85e-02 8.82e-01
FOXO-mediated transcription of cell cycle genes 15 6.97e-01 5.81e-02 8.92e-01
Diseases of mitotic cell cycle 38 5.36e-01 -5.81e-02 8.12e-01
Regulation of FZD by ubiquitination 16 6.89e-01 5.78e-02 8.90e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 6.80e-01 -5.78e-02 8.89e-01
NCAM1 interactions 27 6.05e-01 -5.75e-02 8.52e-01
DNA Damage Reversal 8 7.78e-01 -5.75e-02 9.23e-01
RNA Polymerase III Abortive And Retractive Initiation 41 5.29e-01 5.69e-02 8.06e-01
RNA Polymerase III Transcription 41 5.29e-01 5.69e-02 8.06e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 6.45e-01 5.68e-02 8.75e-01
FGFR1 mutant receptor activation 25 6.25e-01 5.65e-02 8.63e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 2.91e-01 5.65e-02 6.26e-01
RAF-independent MAPK1/3 activation 22 6.49e-01 5.61e-02 8.78e-01
G alpha (i) signalling events 194 1.78e-01 5.60e-02 5.05e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 7.27e-01 5.60e-02 9.14e-01
Transcriptional regulation by RUNX2 92 3.54e-01 5.59e-02 6.73e-01
Complex I biogenesis 66 4.34e-01 5.56e-02 7.34e-01
Phosphorylation of the APC/C 20 6.68e-01 5.53e-02 8.82e-01
RNA Polymerase I Transcription Termination 30 6.00e-01 5.53e-02 8.51e-01
Aerobic respiration and respiratory electron transport 245 1.37e-01 5.51e-02 4.39e-01
RHOV GTPase cycle 36 5.68e-01 -5.50e-02 8.30e-01
Signaling by VEGF 100 3.42e-01 5.49e-02 6.60e-01
G1/S Transition 120 3.02e-01 5.46e-02 6.33e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 8.03e-01 5.43e-02 9.29e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 6.75e-01 5.41e-02 8.87e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 3.28e-01 5.40e-02 6.49e-01
Mitotic G1 phase and G1/S transition 138 2.74e-01 5.39e-02 6.07e-01
Platelet calcium homeostasis 22 6.62e-01 5.39e-02 8.82e-01
FOXO-mediated transcription of cell death genes 16 7.09e-01 5.38e-02 9.00e-01
G alpha (q) signalling events 139 2.74e-01 5.38e-02 6.07e-01
Signaling by NOTCH 175 2.21e-01 5.36e-02 5.55e-01
Myogenesis 21 6.71e-01 -5.36e-02 8.84e-01
Signaling by FGFR1 in disease 32 6.00e-01 5.36e-02 8.51e-01
Metabolism of amine-derived hormones 10 7.70e-01 -5.34e-02 9.20e-01
MicroRNA (miRNA) biogenesis 24 6.51e-01 5.34e-02 8.79e-01
ESR-mediated signaling 160 2.44e-01 5.33e-02 5.80e-01
Defective B3GAT3 causes JDSSDHD 11 7.60e-01 -5.32e-02 9.20e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 3.33e-01 5.32e-02 6.50e-01
Pyruvate metabolism 44 5.42e-01 5.32e-02 8.17e-01
Metabolism of proteins 1777 1.97e-04 5.32e-02 6.79e-03
Developmental Biology 929 6.29e-03 5.29e-02 8.27e-02
Dectin-1 mediated noncanonical NF-kB signaling 48 5.27e-01 5.28e-02 8.06e-01
Formation of definitive endoderm 9 7.84e-01 5.27e-02 9.24e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 1.33e-01 5.27e-02 4.32e-01
Regulation of endogenous retroelements 92 3.83e-01 -5.26e-02 7.04e-01
RUNX2 regulates genes involved in cell migration 6 8.24e-01 -5.24e-02 9.43e-01
Interaction between L1 and Ankyrins 26 6.45e-01 -5.23e-02 8.75e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 7.45e-01 5.22e-02 9.19e-01
Transcriptional Regulation by E2F6 34 5.98e-01 -5.22e-02 8.51e-01
RND3 GTPase cycle 36 5.88e-01 5.21e-02 8.47e-01
Constitutive Signaling by Overexpressed ERBB2 11 7.65e-01 5.21e-02 9.20e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 6.52e-01 5.21e-02 8.80e-01
Influenza Viral RNA Transcription and Replication 135 2.96e-01 -5.21e-02 6.30e-01
SHC1 events in ERBB2 signaling 17 7.11e-01 5.19e-02 9.01e-01
Oncogenic MAPK signaling 76 4.34e-01 5.19e-02 7.34e-01
Chromatin modifying enzymes 215 1.91e-01 -5.17e-02 5.19e-01
Chromatin organization 215 1.91e-01 -5.17e-02 5.19e-01
SHC-related events triggered by IGF1R 8 8.00e-01 -5.17e-02 9.27e-01
Intra-Golgi traffic 43 5.58e-01 5.16e-02 8.27e-01
Ion homeostasis 42 5.64e-01 -5.15e-02 8.30e-01
Fatty acid metabolism 155 2.70e-01 -5.14e-02 6.04e-01
SUMOylation of intracellular receptors 26 6.52e-01 -5.11e-02 8.80e-01
Viral Infection Pathways 776 1.56e-02 5.10e-02 1.49e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 8.29e-01 -5.08e-02 9.46e-01
MTOR signalling 39 5.84e-01 5.06e-02 8.45e-01
Defective GALNT12 causes CRCS1 9 7.93e-01 -5.06e-02 9.25e-01
Keratan sulfate/keratin metabolism 28 6.45e-01 5.04e-02 8.75e-01
ERK/MAPK targets 22 6.83e-01 5.02e-02 8.89e-01
G alpha (s) signalling events 97 3.95e-01 -5.00e-02 7.13e-01
MAPK family signaling cascades 264 1.62e-01 5.00e-02 4.82e-01
RUNX2 regulates bone development 26 6.60e-01 4.99e-02 8.82e-01
CDC42 GTPase cycle 141 3.08e-01 4.98e-02 6.34e-01
Integrin cell surface interactions 68 4.78e-01 4.98e-02 7.69e-01
Disorders of transmembrane transporters 137 3.15e-01 4.98e-02 6.39e-01
Interleukin-12 signaling 44 5.69e-01 4.96e-02 8.30e-01
Downregulation of ERBB2 signaling 24 6.74e-01 -4.96e-02 8.87e-01
Molecules associated with elastic fibres 26 6.62e-01 -4.96e-02 8.82e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 6.07e-01 -4.96e-02 8.52e-01
Hedgehog ‘on’ state 65 4.92e-01 4.93e-02 7.76e-01
FGFR2c ligand binding and activation 5 8.49e-01 -4.93e-02 9.58e-01
Rab regulation of trafficking 122 3.47e-01 4.93e-02 6.66e-01
Immune System 1841 4.63e-04 4.92e-02 1.38e-02
Sema3A PAK dependent Axon repulsion 15 7.43e-01 4.90e-02 9.18e-01
Synthesis of Ketone Bodies 6 8.36e-01 4.89e-02 9.49e-01
RAS signaling downstream of NF1 loss-of-function variants 7 8.24e-01 4.86e-02 9.43e-01
Lewis blood group biosynthesis 14 7.53e-01 4.85e-02 9.20e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 7.54e-01 4.84e-02 9.20e-01
Regulation of TNFR1 signaling 47 5.67e-01 -4.83e-02 8.30e-01
Defective B4GALT7 causes EDS, progeroid type 11 7.82e-01 -4.82e-02 9.24e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 7.56e-01 4.79e-02 9.20e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 7.18e-01 -4.78e-02 9.09e-01
Formation of apoptosome 11 7.84e-01 4.78e-02 9.24e-01
Regulation of the apoptosome activity 11 7.84e-01 4.78e-02 9.24e-01
IGF1R signaling cascade 38 6.10e-01 4.78e-02 8.55e-01
PI3K events in ERBB2 signaling 11 7.84e-01 4.77e-02 9.24e-01
Germ layer formation at gastrulation 9 8.05e-01 4.76e-02 9.30e-01
Signaling by NOTCH2 33 6.36e-01 -4.76e-02 8.71e-01
Processing of SMDT1 15 7.50e-01 -4.76e-02 9.20e-01
Regulation of expression of SLITs and ROBOs 149 3.18e-01 4.74e-02 6.44e-01
RHOA GTPase cycle 139 3.35e-01 4.74e-02 6.51e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 8.55e-01 -4.73e-02 9.60e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 6.95e-01 -4.72e-02 8.92e-01
Nuclear Envelope Breakdown 53 5.52e-01 -4.72e-02 8.23e-01
FGFR4 ligand binding and activation 5 8.56e-01 -4.69e-02 9.61e-01
Signaling by ALK fusions and activated point mutants 89 4.44e-01 -4.69e-02 7.36e-01
Signaling by ALK in cancer 89 4.44e-01 -4.69e-02 7.36e-01
COPII-mediated vesicle transport 67 5.08e-01 4.68e-02 7.91e-01
IRS-related events triggered by IGF1R 37 6.23e-01 4.67e-02 8.62e-01
Nef and signal transduction 8 8.20e-01 -4.66e-02 9.40e-01
Activation of RAC1 11 7.91e-01 -4.63e-02 9.24e-01
Glycosphingolipid biosynthesis 15 7.56e-01 4.62e-02 9.20e-01
RND1 GTPase cycle 37 6.27e-01 4.62e-02 8.63e-01
DNA Double-Strand Break Repair 137 3.51e-01 -4.61e-02 6.72e-01
Neddylation 215 2.44e-01 4.61e-02 5.80e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 5.51e-01 4.61e-02 8.22e-01
Loss of Function of TGFBR1 in Cancer 7 8.33e-01 4.60e-02 9.48e-01
Uptake and actions of bacterial toxins 28 6.75e-01 -4.58e-02 8.87e-01
HIV elongation arrest and recovery 32 6.57e-01 4.54e-02 8.82e-01
Pausing and recovery of HIV elongation 32 6.57e-01 4.54e-02 8.82e-01
Cap-dependent Translation Initiation 118 3.95e-01 4.53e-02 7.13e-01
Eukaryotic Translation Initiation 118 3.95e-01 4.53e-02 7.13e-01
Transmission across Chemical Synapses 188 2.84e-01 4.53e-02 6.18e-01
Cellular Senescence 143 3.53e-01 4.50e-02 6.73e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.68e-01 -4.50e-02 7.59e-01
TBC/RABGAPs 45 6.02e-01 4.49e-02 8.51e-01
Glycerophospholipid biosynthesis 105 4.27e-01 4.49e-02 7.30e-01
Synthesis of PA 31 6.66e-01 -4.48e-02 8.82e-01
IRF3-mediated induction of type I IFN 12 7.88e-01 4.48e-02 9.24e-01
Toll-like Receptor Cascades 162 3.26e-01 -4.47e-02 6.48e-01
Signaling by ROBO receptors 189 2.89e-01 4.47e-02 6.24e-01
Drug ADME 59 5.56e-01 -4.44e-02 8.26e-01
Mitotic Prometaphase 193 2.94e-01 4.38e-02 6.29e-01
Acyl chain remodeling of CL 5 8.66e-01 -4.37e-02 9.63e-01
Transcriptional regulation by small RNAs 61 5.58e-01 4.34e-02 8.27e-01
ISG15 antiviral mechanism 72 5.25e-01 -4.33e-02 8.06e-01
Glucagon-type ligand receptors 20 7.39e-01 4.30e-02 9.18e-01
Dissolution of Fibrin Clot 12 7.97e-01 -4.30e-02 9.25e-01
SARS-CoV Infections 433 1.26e-01 4.29e-02 4.23e-01
FGFR3 ligand binding and activation 5 8.68e-01 -4.28e-02 9.63e-01
FGFR3c ligand binding and activation 5 8.68e-01 -4.28e-02 9.63e-01
Negative regulators of DDX58/IFIH1 signaling 34 6.67e-01 -4.27e-02 8.82e-01
Muscle contraction 145 3.78e-01 4.24e-02 6.99e-01
RAC3 GTPase cycle 88 4.92e-01 4.24e-02 7.76e-01
Metabolism of folate and pterines 16 7.70e-01 4.23e-02 9.20e-01
Nicotinate metabolism 26 7.10e-01 -4.22e-02 9.00e-01
Elastic fibre formation 33 6.75e-01 -4.22e-02 8.87e-01
Transport of small molecules 558 8.98e-02 4.20e-02 3.75e-01
PKA activation in glucagon signalling 14 7.86e-01 4.19e-02 9.24e-01
Transport of vitamins, nucleosides, and related molecules 32 6.82e-01 4.19e-02 8.89e-01
Androgen biosynthesis 5 8.71e-01 -4.18e-02 9.63e-01
TP53 Regulates Transcription of DNA Repair Genes 61 5.74e-01 -4.16e-02 8.35e-01
Erythropoietin activates RAS 13 7.96e-01 4.14e-02 9.25e-01
Synthesis of UDP-N-acetyl-glucosamine 8 8.39e-01 4.14e-02 9.51e-01
Reproduction 85 5.10e-01 4.14e-02 7.93e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 6.60e-01 4.13e-02 8.82e-01
Sensory processing of sound by outer hair cells of the cochlea 41 6.49e-01 4.11e-02 8.78e-01
Activated NTRK2 signals through RAS 6 8.62e-01 4.10e-02 9.63e-01
Disease 1633 5.79e-03 4.10e-02 8.05e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 8.15e-01 -4.08e-02 9.39e-01
NCAM signaling for neurite out-growth 48 6.26e-01 -4.07e-02 8.63e-01
Specification of primordial germ cells 6 8.63e-01 4.06e-02 9.63e-01
Factors involved in megakaryocyte development and platelet production 129 4.27e-01 4.05e-02 7.30e-01
SHC-mediated cascade:FGFR2 13 8.01e-01 -4.05e-02 9.27e-01
Mitotic G2-G2/M phases 179 3.51e-01 4.04e-02 6.72e-01
Formation of Incision Complex in GG-NER 43 6.48e-01 4.03e-02 8.78e-01
WNT5A-dependent internalization of FZD4 13 8.02e-01 4.01e-02 9.29e-01
Class A/1 (Rhodopsin-like receptors) 175 3.60e-01 4.01e-02 6.79e-01
mRNA Splicing - Major Pathway 203 3.26e-01 -4.00e-02 6.48e-01
Integration of energy metabolism 88 5.20e-01 3.97e-02 8.04e-01
Processing of Capped Intron-Containing Pre-mRNA 279 2.55e-01 -3.96e-02 5.90e-01
mRNA Splicing 211 3.22e-01 -3.96e-02 6.46e-01
Hyaluronan metabolism 16 7.85e-01 3.94e-02 9.24e-01
Signaling by Hedgehog 120 4.57e-01 3.93e-02 7.49e-01
CS/DS degradation 9 8.39e-01 -3.90e-02 9.51e-01
MHC class II antigen presentation 113 4.76e-01 3.88e-02 7.67e-01
RND2 GTPase cycle 37 6.83e-01 -3.88e-02 8.89e-01
Signaling by ERBB2 44 6.57e-01 3.87e-02 8.82e-01
Signaling by NTRKs 117 4.71e-01 3.86e-02 7.62e-01
IKK complex recruitment mediated by RIP1 23 7.51e-01 3.82e-02 9.20e-01
Elevation of cytosolic Ca2+ levels 13 8.13e-01 3.79e-02 9.38e-01
RHO GTPases Activate NADPH Oxidases 21 7.65e-01 3.77e-02 9.20e-01
HIV Transcription Initiation 45 6.61e-01 -3.77e-02 8.82e-01
RNA Polymerase II HIV Promoter Escape 45 6.61e-01 -3.77e-02 8.82e-01
RNA Polymerase II Promoter Escape 45 6.61e-01 -3.77e-02 8.82e-01
RNA Polymerase II Transcription Initiation 45 6.61e-01 -3.77e-02 8.82e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 6.61e-01 -3.77e-02 8.82e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 6.61e-01 -3.77e-02 8.82e-01
Synthesis of IP3 and IP4 in the cytosol 22 7.59e-01 -3.77e-02 9.20e-01
Influenza Infection 154 4.22e-01 -3.75e-02 7.27e-01
Formation of the nephric duct 8 8.55e-01 3.74e-02 9.60e-01
RHOU GTPase cycle 40 6.83e-01 -3.74e-02 8.89e-01
Biosynthesis of E-series 18(S)-resolvins 5 8.85e-01 3.72e-02 9.67e-01
RUNX3 Regulates Immune Response and Cell Migration 6 8.75e-01 3.72e-02 9.63e-01
Association of TriC/CCT with target proteins during biosynthesis 35 7.05e-01 3.70e-02 8.97e-01
Transport of Mature Transcript to Cytoplasm 81 5.66e-01 -3.69e-02 8.30e-01
DNA Double Strand Break Response 47 6.62e-01 3.69e-02 8.82e-01
E2F mediated regulation of DNA replication 22 7.65e-01 3.69e-02 9.20e-01
Activation of caspases through apoptosome-mediated cleavage 6 8.76e-01 -3.69e-02 9.63e-01
Cytochrome P450 - arranged by substrate type 38 6.96e-01 -3.66e-02 8.92e-01
Formation of axial mesoderm 6 8.80e-01 3.56e-02 9.64e-01
Cholesterol biosynthesis 26 7.54e-01 3.55e-02 9.20e-01
Azathioprine ADME 21 7.79e-01 -3.54e-02 9.23e-01
Downstream signaling of activated FGFR2 20 7.84e-01 3.53e-02 9.24e-01
tRNA processing 128 4.91e-01 3.53e-02 7.76e-01
G0 and Early G1 27 7.52e-01 3.51e-02 9.20e-01
Interconversion of nucleotide di- and triphosphates 27 7.54e-01 3.48e-02 9.20e-01
Peptide hormone metabolism 54 6.60e-01 -3.46e-02 8.82e-01
Loss of Nlp from mitotic centrosomes 69 6.20e-01 -3.45e-02 8.61e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 6.20e-01 -3.45e-02 8.61e-01
CD28 co-stimulation 33 7.32e-01 -3.44e-02 9.17e-01
Downregulation of ERBB4 signaling 8 8.66e-01 3.44e-02 9.63e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 8.75e-01 3.43e-02 9.63e-01
Adenylate cyclase inhibitory pathway 11 8.44e-01 -3.43e-02 9.55e-01
p75NTR negatively regulates cell cycle via SC1 5 8.95e-01 -3.41e-02 9.70e-01
Growth hormone receptor signaling 21 7.87e-01 3.41e-02 9.24e-01
Sensory processing of sound 58 6.55e-01 -3.39e-02 8.82e-01
RET signaling 32 7.41e-01 3.38e-02 9.18e-01
Post NMDA receptor activation events 64 6.40e-01 3.38e-02 8.75e-01
Acyl chain remodelling of PE 20 7.94e-01 3.37e-02 9.25e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 6.99e-01 3.36e-02 8.93e-01
Inflammasomes 21 7.90e-01 -3.36e-02 9.24e-01
Signaling by CSF3 (G-CSF) 29 7.55e-01 3.35e-02 9.20e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.28e-01 -3.35e-02 9.45e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.28e-01 -3.35e-02 9.45e-01
Interleukin-7 signaling 21 7.91e-01 -3.34e-02 9.24e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 7.82e-01 3.33e-02 9.24e-01
Translesion Synthesis by POLH 18 8.07e-01 -3.33e-02 9.32e-01
Post-translational protein modification 1243 4.94e-02 3.31e-02 2.84e-01
Ribavirin ADME 11 8.50e-01 -3.30e-02 9.58e-01
TCR signaling 110 5.52e-01 -3.28e-02 8.23e-01
G1/S-Specific Transcription 29 7.61e-01 3.26e-02 9.20e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 7.03e-01 3.25e-02 8.96e-01
Interleukin-4 and Interleukin-13 signaling 93 5.90e-01 3.24e-02 8.47e-01
Listeria monocytogenes entry into host cells 17 8.18e-01 3.22e-02 9.40e-01
Ubiquinol biosynthesis 13 8.41e-01 3.22e-02 9.52e-01
Pausing and recovery of Tat-mediated HIV elongation 30 7.61e-01 3.21e-02 9.20e-01
Tat-mediated HIV elongation arrest and recovery 30 7.61e-01 3.21e-02 9.20e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.13e-01 -3.21e-02 9.38e-01
Signaling by EGFR in Cancer 23 7.90e-01 3.21e-02 9.24e-01
Neurotransmitter release cycle 38 7.34e-01 -3.18e-02 9.17e-01
FGFR2b ligand binding and activation 6 8.93e-01 3.18e-02 9.70e-01
Activation of NMDA receptors and postsynaptic events 74 6.38e-01 3.17e-02 8.72e-01
Hedgehog ‘off’ state 91 6.02e-01 3.17e-02 8.51e-01
Transcriptional Regulation by NPAS4 27 7.76e-01 -3.16e-02 9.22e-01
Stimuli-sensing channels 81 6.23e-01 -3.16e-02 8.63e-01
G2/M Transition 177 4.69e-01 3.16e-02 7.59e-01
Processing and activation of SUMO 10 8.63e-01 3.16e-02 9.63e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 7.44e-01 3.14e-02 9.19e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 9.03e-01 -3.14e-02 9.73e-01
Sensory perception of taste 22 8.00e-01 3.13e-02 9.27e-01
TAK1-dependent IKK and NF-kappa-B activation 43 7.25e-01 -3.10e-02 9.14e-01
Activation of ATR in response to replication stress 37 7.44e-01 -3.10e-02 9.19e-01
Signaling by SCF-KIT 40 7.35e-01 3.09e-02 9.17e-01
Regulation of BACH1 activity 11 8.60e-01 3.08e-02 9.62e-01
RIPK1-mediated regulated necrosis 31 7.67e-01 3.08e-02 9.20e-01
Regulation of necroptotic cell death 31 7.67e-01 3.08e-02 9.20e-01
ERBB2 Activates PTK6 Signaling 8 8.81e-01 -3.06e-02 9.64e-01
CLEC7A (Dectin-1) signaling 86 6.26e-01 3.04e-02 8.63e-01
Transcription of E2F targets under negative control by DREAM complex 19 8.19e-01 -3.03e-02 9.40e-01
Signaling by NOTCH1 68 6.67e-01 -3.02e-02 8.82e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 8.76e-01 -3.01e-02 9.63e-01
Signaling by Interleukins 391 3.10e-01 2.99e-02 6.37e-01
Endosomal/Vacuolar pathway 12 8.60e-01 2.95e-02 9.62e-01
Cargo concentration in the ER 31 7.77e-01 2.93e-02 9.23e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 8.79e-01 2.93e-02 9.64e-01
Activation of PUMA and translocation to mitochondria 9 8.80e-01 -2.90e-02 9.64e-01
Signal Transduction 2058 3.05e-02 2.89e-02 2.09e-01
O-linked glycosylation of mucins 47 7.32e-01 2.88e-02 9.17e-01
PI3K/AKT Signaling in Cancer 85 6.47e-01 2.87e-02 8.78e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 9.04e-01 2.83e-02 9.73e-01
Biosynthesis of EPA-derived SPMs 6 9.05e-01 -2.82e-02 9.73e-01
RNA polymerase II transcribes snRNA genes 71 6.83e-01 -2.80e-02 8.89e-01
p38MAPK events 13 8.61e-01 2.80e-02 9.63e-01
Synthesis of PIPs at the plasma membrane 52 7.29e-01 -2.78e-02 9.15e-01
Defective C1GALT1C1 causes TNPS 10 8.80e-01 -2.76e-02 9.64e-01
Nucleotide salvage 21 8.28e-01 -2.74e-02 9.45e-01
AURKA Activation by TPX2 72 6.89e-01 -2.73e-02 8.90e-01
CRMPs in Sema3A signaling 13 8.65e-01 2.73e-02 9.63e-01
Oncogene Induced Senescence 33 7.88e-01 2.71e-02 9.24e-01
DNA Damage Recognition in GG-NER 38 7.73e-01 2.70e-02 9.21e-01
Plasma lipoprotein clearance 33 7.89e-01 -2.70e-02 9.24e-01
Wax and plasmalogen biosynthesis 5 9.17e-01 2.69e-02 9.76e-01
Activation of C3 and C5 7 9.02e-01 2.68e-02 9.73e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 8.96e-01 2.67e-02 9.70e-01
Cell Cycle, Mitotic 488 3.19e-01 2.63e-02 6.46e-01
Ca2+ pathway 58 7.29e-01 2.63e-02 9.15e-01
Tie2 Signaling 16 8.56e-01 2.61e-02 9.61e-01
EPH-ephrin mediated repulsion of cells 43 7.68e-01 -2.60e-02 9.20e-01
HIV Life Cycle 144 5.90e-01 -2.60e-02 8.47e-01
Ovarian tumor domain proteases 37 7.85e-01 2.59e-02 9.24e-01
Biological oxidations 146 5.89e-01 2.59e-02 8.47e-01
PKA-mediated phosphorylation of CREB 17 8.54e-01 -2.58e-02 9.60e-01
SARS-CoV-1-host interactions 95 6.65e-01 -2.57e-02 8.82e-01
Signaling by TGFB family members 139 6.03e-01 2.56e-02 8.51e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 8.78e-01 -2.55e-02 9.64e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 9.01e-01 -2.55e-02 9.73e-01
mRNA 3’-end processing 57 7.41e-01 2.53e-02 9.18e-01
Acyl chain remodelling of PG 11 8.85e-01 2.53e-02 9.67e-01
Epigenetic regulation of gene expression 263 4.81e-01 -2.52e-02 7.71e-01
Inactivation of CSF3 (G-CSF) signaling 24 8.31e-01 -2.51e-02 9.47e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 7.74e-01 -2.50e-02 9.22e-01
HDACs deacetylate histones 45 7.74e-01 -2.47e-02 9.22e-01
Cyclin D associated events in G1 47 7.70e-01 -2.46e-02 9.20e-01
G1 Phase 47 7.70e-01 -2.46e-02 9.20e-01
PTEN Regulation 127 6.36e-01 -2.44e-02 8.71e-01
SARS-CoV-2 modulates host translation machinery 49 7.68e-01 -2.43e-02 9.20e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 8.60e-01 -2.41e-02 9.62e-01
Metabolism of cofactors 25 8.36e-01 -2.40e-02 9.49e-01
Striated Muscle Contraction 27 8.30e-01 2.39e-02 9.46e-01
MyD88 cascade initiated on plasma membrane 95 6.88e-01 2.39e-02 8.90e-01
Toll Like Receptor 10 (TLR10) Cascade 95 6.88e-01 2.39e-02 8.90e-01
Toll Like Receptor 5 (TLR5) Cascade 95 6.88e-01 2.39e-02 8.90e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 8.65e-01 2.38e-02 9.63e-01
RAC1 GTPase cycle 173 5.89e-01 -2.38e-02 8.47e-01
HIV Infection 213 5.50e-01 2.37e-02 8.22e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 7.98e-01 2.36e-02 9.27e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 7.91e-01 2.36e-02 9.24e-01
HIV Transcription Elongation 42 7.91e-01 2.36e-02 9.24e-01
Tat-mediated elongation of the HIV-1 transcript 42 7.91e-01 2.36e-02 9.24e-01
Glycolysis 68 7.36e-01 -2.36e-02 9.17e-01
MITF-M-regulated melanocyte development 113 6.65e-01 2.36e-02 8.82e-01
Activation of the pre-replicative complex 32 8.19e-01 -2.33e-02 9.40e-01
Diseases of metabolism 208 5.63e-01 2.33e-02 8.30e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 7.67e-01 -2.31e-02 9.20e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 7.67e-01 -2.31e-02 9.20e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 7.67e-01 -2.31e-02 9.20e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 7.67e-01 -2.31e-02 9.20e-01
Signaling by NOTCH1 in Cancer 55 7.67e-01 -2.31e-02 9.20e-01
Collagen formation 66 7.45e-01 -2.31e-02 9.19e-01
IkBA variant leads to EDA-ID 7 9.16e-01 -2.31e-02 9.76e-01
SLC-mediated transmembrane transport 175 6.01e-01 2.29e-02 8.51e-01
Regulated Necrosis 56 7.69e-01 -2.27e-02 9.20e-01
Retrograde transport at the Trans-Golgi-Network 49 7.83e-01 -2.27e-02 9.24e-01
Bile acid and bile salt metabolism 31 8.27e-01 -2.27e-02 9.45e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.18e-01 2.25e-02 9.76e-01
Citric acid cycle (TCA cycle) 34 8.20e-01 2.25e-02 9.40e-01
Signaling by FGFR4 in disease 11 8.97e-01 -2.25e-02 9.71e-01
Loss of Function of SMAD2/3 in Cancer 7 9.18e-01 -2.24e-02 9.76e-01
Metabolism of carbohydrates 241 5.49e-01 2.24e-02 8.22e-01
Constitutive Signaling by Aberrant PI3K in Cancer 59 7.66e-01 2.24e-02 9.20e-01
FGFR2 mutant receptor activation 23 8.53e-01 -2.23e-02 9.60e-01
Effects of PIP2 hydrolysis 24 8.51e-01 2.22e-02 9.58e-01
PECAM1 interactions 12 8.94e-01 -2.22e-02 9.70e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 8.74e-01 2.21e-02 9.63e-01
VEGFR2 mediated cell proliferation 18 8.72e-01 -2.19e-02 9.63e-01
Cellular response to mitochondrial stress 9 9.11e-01 2.16e-02 9.76e-01
Cell Cycle 611 3.62e-01 2.16e-02 6.81e-01
Early SARS-CoV-2 Infection Events 31 8.35e-01 2.16e-02 9.49e-01
CREB phosphorylation 7 9.22e-01 2.14e-02 9.77e-01
Signaling by ERBB2 in Cancer 21 8.66e-01 -2.13e-02 9.63e-01
Toll Like Receptor 4 (TLR4) Cascade 138 6.66e-01 -2.13e-02 8.82e-01
Toll Like Receptor 9 (TLR9) Cascade 108 7.03e-01 -2.12e-02 8.96e-01
Abacavir ADME 5 9.35e-01 2.11e-02 9.81e-01
Host Interactions of HIV factors 118 6.93e-01 2.11e-02 8.91e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 8.72e-01 2.09e-02 9.63e-01
Trafficking of AMPA receptors 20 8.72e-01 2.09e-02 9.63e-01
Phase 0 - rapid depolarisation 24 8.60e-01 -2.08e-02 9.62e-01
Selenocysteine synthesis 92 7.34e-01 -2.05e-02 9.17e-01
TNFR2 non-canonical NF-kB pathway 84 7.46e-01 -2.04e-02 9.19e-01
Metabolism of Angiotensinogen to Angiotensins 12 9.03e-01 -2.03e-02 9.73e-01
Nitric oxide stimulates guanylate cyclase 15 8.92e-01 -2.03e-02 9.70e-01
RNA Polymerase II Pre-transcription Events 77 7.58e-01 -2.03e-02 9.20e-01
Cardiac conduction 89 7.41e-01 -2.03e-02 9.18e-01
Eicosanoid ligand-binding receptors 13 9.00e-01 2.02e-02 9.72e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 7.35e-01 2.02e-02 9.17e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 9.26e-01 2.02e-02 9.79e-01
Transcriptional Regulation by TP53 346 5.23e-01 2.00e-02 8.06e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 7.68e-01 1.99e-02 9.20e-01
Assembly of collagen fibrils and other multimeric structures 44 8.20e-01 1.98e-02 9.40e-01
Deadenylation-dependent mRNA decay 50 8.09e-01 -1.98e-02 9.33e-01
Phase I - Functionalization of compounds 70 7.76e-01 1.97e-02 9.22e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 9.29e-01 -1.93e-02 9.80e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.35e-01 1.92e-02 9.81e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.35e-01 1.92e-02 9.81e-01
WNT mediated activation of DVL 8 9.25e-01 1.92e-02 9.78e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 7.34e-01 1.90e-02 9.17e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 7.34e-01 1.90e-02 9.17e-01
Cytokine Signaling in Immune system 670 4.09e-01 -1.87e-02 7.14e-01
Regulation of TP53 Activity through Phosphorylation 88 7.62e-01 1.87e-02 9.20e-01
Metabolism of RNA 718 3.96e-01 1.86e-02 7.13e-01
Transcription of the HIV genome 67 7.93e-01 1.85e-02 9.25e-01
Mitochondrial biogenesis 91 7.65e-01 1.82e-02 9.20e-01
FRS-mediated FGFR2 signaling 15 9.04e-01 1.80e-02 9.73e-01
EGFR interacts with phospholipase C-gamma 7 9.35e-01 -1.78e-02 9.81e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 9.26e-01 -1.78e-02 9.79e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.73e-01 -1.78e-02 9.63e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.73e-01 -1.78e-02 9.63e-01
Signaling by PDGFR in disease 19 8.93e-01 -1.77e-02 9.70e-01
Ethanol oxidation 8 9.31e-01 -1.77e-02 9.80e-01
G-protein beta:gamma signalling 29 8.69e-01 1.77e-02 9.63e-01
Eukaryotic Translation Elongation 93 7.69e-01 -1.76e-02 9.20e-01
Metabolism of steroids 125 7.36e-01 1.75e-02 9.17e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.93e-01 1.74e-02 9.70e-01
O-glycosylation of TSR domain-containing proteins 28 8.74e-01 -1.73e-02 9.63e-01
Signal regulatory protein family interactions 13 9.14e-01 1.73e-02 9.76e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 5.51e-01 1.73e-02 8.22e-01
Relaxin receptors 5 9.48e-01 1.68e-02 9.87e-01
Homology Directed Repair 110 7.61e-01 -1.68e-02 9.20e-01
Signaling by PDGFRA extracellular domain mutants 12 9.20e-01 1.68e-02 9.76e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 9.20e-01 1.68e-02 9.76e-01
Formation of TC-NER Pre-Incision Complex 51 8.36e-01 1.67e-02 9.49e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 9.24e-01 -1.66e-02 9.78e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 7.76e-01 1.65e-02 9.22e-01
Ion channel transport 141 7.39e-01 -1.62e-02 9.18e-01
Formation of a pool of free 40S subunits 100 7.83e-01 1.59e-02 9.24e-01
Downstream TCR signaling 89 7.95e-01 -1.59e-02 9.25e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 9.22e-01 1.57e-02 9.77e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 8.77e-01 -1.53e-02 9.63e-01
Free fatty acids regulate insulin secretion 10 9.34e-01 -1.52e-02 9.81e-01
MyD88 dependent cascade initiated on endosome 101 7.93e-01 -1.51e-02 9.25e-01
Signaling by FGFR2 IIIa TM 18 9.13e-01 1.50e-02 9.76e-01
Metabolism of fat-soluble vitamins 28 8.95e-01 1.44e-02 9.70e-01
Collagen chain trimerization 29 8.94e-01 1.43e-02 9.70e-01
Synthesis of substrates in N-glycan biosythesis 59 8.49e-01 1.43e-02 9.58e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 9.29e-01 1.43e-02 9.80e-01
Regulation of NF-kappa B signaling 18 9.17e-01 1.42e-02 9.76e-01
Signaling by Nuclear Receptors 214 7.21e-01 -1.42e-02 9.11e-01
Signaling by ERBB4 45 8.70e-01 1.41e-02 9.63e-01
Retinoid metabolism and transport 25 9.03e-01 -1.41e-02 9.73e-01
Peptide chain elongation 88 8.20e-01 -1.40e-02 9.40e-01
Formation of RNA Pol II elongation complex 56 8.58e-01 -1.39e-02 9.61e-01
RNA Polymerase II Transcription Elongation 56 8.58e-01 -1.39e-02 9.61e-01
Eukaryotic Translation Termination 92 8.19e-01 -1.38e-02 9.40e-01
Phospholipid metabolism 183 7.49e-01 -1.37e-02 9.20e-01
GPCR ligand binding 241 7.21e-01 1.34e-02 9.11e-01
p75 NTR receptor-mediated signalling 89 8.28e-01 -1.33e-02 9.45e-01
PIP3 activates AKT signaling 235 7.27e-01 1.32e-02 9.14e-01
TYSND1 cleaves peroxisomal proteins 7 9.52e-01 -1.31e-02 9.90e-01
Receptor-type tyrosine-protein phosphatases 12 9.38e-01 1.30e-02 9.83e-01
O-linked glycosylation 85 8.41e-01 -1.26e-02 9.52e-01
Downstream signal transduction 27 9.11e-01 -1.25e-02 9.76e-01
STAT5 Activation 7 9.55e-01 -1.24e-02 9.90e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 9.16e-01 1.22e-02 9.76e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 9.16e-01 1.22e-02 9.76e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 9.16e-01 1.22e-02 9.76e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 9.16e-01 1.22e-02 9.76e-01
Signaling by NTRK1 (TRKA) 102 8.32e-01 1.22e-02 9.47e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 9.53e-01 1.21e-02 9.90e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 9.45e-01 -1.20e-02 9.86e-01
Cytosolic sensors of pathogen-associated DNA 63 8.69e-01 1.20e-02 9.63e-01
The canonical retinoid cycle in rods (twilight vision) 9 9.53e-01 -1.14e-02 9.90e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 9.62e-01 1.14e-02 9.90e-01
TGFBR1 KD Mutants in Cancer 6 9.62e-01 1.14e-02 9.90e-01
Branched-chain amino acid catabolism 21 9.28e-01 -1.13e-02 9.80e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 9.06e-01 -1.13e-02 9.73e-01
Signaling by GPCR 442 6.92e-01 -1.10e-02 8.91e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 8.51e-01 -1.09e-02 9.58e-01
mRNA Splicing - Minor Pathway 50 8.95e-01 -1.08e-02 9.70e-01
TRAIL signaling 8 9.58e-01 -1.07e-02 9.90e-01
VEGFR2 mediated vascular permeability 26 9.25e-01 -1.07e-02 9.78e-01
Toll Like Receptor 2 (TLR2) Cascade 109 8.49e-01 1.05e-02 9.58e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 8.49e-01 1.05e-02 9.58e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 9.65e-01 1.05e-02 9.90e-01
G alpha (12/13) signalling events 68 8.82e-01 -1.04e-02 9.64e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 8.72e-01 -1.04e-02 9.63e-01
Reversal of alkylation damage by DNA dioxygenases 7 9.62e-01 1.03e-02 9.90e-01
Resolution of D-Loop Structures 35 9.16e-01 -1.03e-02 9.76e-01
MITF-M-dependent gene expression 83 8.71e-01 -1.03e-02 9.63e-01
GRB2 events in ERBB2 signaling 11 9.53e-01 1.03e-02 9.90e-01
Calcitonin-like ligand receptors 5 9.69e-01 -1.01e-02 9.90e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 8.99e-01 -9.94e-03 9.72e-01
Collagen biosynthesis and modifying enzymes 48 9.05e-01 -9.94e-03 9.73e-01
Histidine catabolism 7 9.64e-01 -9.72e-03 9.90e-01
ERBB2 Regulates Cell Motility 10 9.58e-01 -9.70e-03 9.90e-01
FGFRL1 modulation of FGFR1 signaling 7 9.65e-01 9.69e-03 9.90e-01
Gene Silencing by RNA 87 8.76e-01 9.66e-03 9.63e-01
Acyl chain remodelling of PC 19 9.42e-01 9.65e-03 9.86e-01
Synthesis of bile acids and bile salts 27 9.31e-01 -9.64e-03 9.80e-01
Recycling of eIF2:GDP 8 9.63e-01 9.54e-03 9.90e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 9.14e-01 -9.05e-03 9.76e-01
FLT3 signaling through SRC family kinases 6 9.70e-01 -9.00e-03 9.90e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 8.74e-01 -8.95e-03 9.63e-01
AKT phosphorylates targets in the cytosol 14 9.54e-01 8.90e-03 9.90e-01
CTLA4 inhibitory signaling 21 9.46e-01 -8.60e-03 9.86e-01
Phospholipase C-mediated cascade; FGFR3 5 9.74e-01 8.53e-03 9.92e-01
Signaling by FGFR in disease 52 9.15e-01 -8.52e-03 9.76e-01
Processing of Capped Intronless Pre-mRNA 29 9.37e-01 8.43e-03 9.83e-01
SUMOylation of transcription cofactors 44 9.24e-01 8.27e-03 9.78e-01
Regulation of signaling by CBL 22 9.47e-01 -8.25e-03 9.87e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 8.85e-01 8.23e-03 9.67e-01
Recruitment of NuMA to mitotic centrosomes 88 8.95e-01 -8.15e-03 9.70e-01
Impaired BRCA2 binding to PALB2 24 9.46e-01 8.05e-03 9.86e-01
RAC2 GTPase cycle 86 8.99e-01 -7.92e-03 9.72e-01
MyD88-independent TLR4 cascade 108 8.91e-01 -7.65e-03 9.70e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 8.91e-01 -7.65e-03 9.70e-01
FGFR2 ligand binding and activation 9 9.69e-01 -7.37e-03 9.90e-01
Apoptotic factor-mediated response 19 9.56e-01 7.31e-03 9.90e-01
Metabolism of nucleotides 85 9.09e-01 -7.18e-03 9.76e-01
IRAK2 mediated activation of TAK1 complex 10 9.69e-01 7.07e-03 9.90e-01
Opioid Signalling 75 9.17e-01 6.99e-03 9.76e-01
Regulation of signaling by NODAL 6 9.77e-01 6.87e-03 9.92e-01
Metabolism of amino acids and derivatives 308 8.36e-01 6.84e-03 9.49e-01
Regulation of beta-cell development 22 9.56e-01 6.81e-03 9.90e-01
Neuronal System 276 8.48e-01 6.71e-03 9.58e-01
Signalling to RAS 19 9.60e-01 -6.66e-03 9.90e-01
Establishment of Sister Chromatid Cohesion 11 9.70e-01 6.55e-03 9.90e-01
Toll Like Receptor 3 (TLR3) Cascade 104 9.09e-01 -6.47e-03 9.76e-01
Constitutive Signaling by EGFRvIII 14 9.67e-01 6.43e-03 9.90e-01
Signaling by EGFRvIII in Cancer 14 9.67e-01 6.43e-03 9.90e-01
S Phase 150 8.93e-01 -6.35e-03 9.70e-01
Plasma lipoprotein assembly 10 9.73e-01 6.21e-03 9.92e-01
Regulation of insulin secretion 63 9.33e-01 6.13e-03 9.81e-01
RNA Polymerase II Transcription Termination 66 9.33e-01 5.94e-03 9.81e-01
Formation of the Early Elongation Complex 33 9.53e-01 5.89e-03 9.90e-01
Formation of the HIV-1 Early Elongation Complex 33 9.53e-01 5.89e-03 9.90e-01
Signaling by FGFR2 in disease 33 9.57e-01 5.38e-03 9.90e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 9.63e-01 5.30e-03 9.90e-01
Diseases of branched-chain amino acid catabolism 13 9.74e-01 5.26e-03 9.92e-01
SARS-CoV-1 modulates host translation machinery 36 9.57e-01 5.16e-03 9.90e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 9.65e-01 -5.12e-03 9.90e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 9.75e-01 -4.97e-03 9.92e-01
PI5P Regulates TP53 Acetylation 8 9.81e-01 4.85e-03 9.94e-01
Antiviral mechanism by IFN-stimulated genes 140 9.21e-01 -4.83e-03 9.77e-01
Acyl chain remodelling of PS 14 9.76e-01 4.74e-03 9.92e-01
SARS-CoV-1 Infection 138 9.29e-01 4.39e-03 9.80e-01
GPCR downstream signalling 398 8.88e-01 -4.11e-03 9.69e-01
Respiratory Syncytial Virus Infection Pathway 99 9.44e-01 4.09e-03 9.86e-01
mRNA Capping 29 9.70e-01 4.08e-03 9.90e-01
C-type lectin receptors (CLRs) 118 9.40e-01 3.98e-03 9.85e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.77e-01 -3.80e-03 9.92e-01
Pre-NOTCH Processing in Golgi 18 9.78e-01 -3.75e-03 9.93e-01
Membrane binding and targetting of GAG proteins 13 9.83e-01 3.46e-03 9.95e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 9.83e-01 3.46e-03 9.95e-01
Potassium Channels 64 9.63e-01 -3.39e-03 9.90e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 9.81e-01 3.38e-03 9.94e-01
Detoxification of Reactive Oxygen Species 30 9.75e-01 3.31e-03 9.92e-01
Cell death signalling via NRAGE, NRIF and NADE 69 9.62e-01 -3.30e-03 9.90e-01
Assembly and cell surface presentation of NMDA receptors 34 9.74e-01 -3.18e-03 9.92e-01
Regulation of TP53 Activity 153 9.48e-01 3.06e-03 9.87e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 9.69e-01 3.02e-03 9.90e-01
Estrogen-dependent gene expression 97 9.60e-01 2.94e-03 9.90e-01
Cytosolic tRNA aminoacylation 24 9.81e-01 -2.87e-03 9.94e-01
NOD1/2 Signaling Pathway 36 9.78e-01 -2.64e-03 9.93e-01
Metabolism of lipids 642 9.10e-01 -2.62e-03 9.76e-01
rRNA modification in the mitochondrion 8 9.90e-01 2.61e-03 9.97e-01
Intracellular signaling by second messengers 268 9.44e-01 -2.51e-03 9.86e-01
mRNA Editing 8 9.90e-01 2.49e-03 9.97e-01
HS-GAG degradation 19 9.85e-01 2.45e-03 9.96e-01
Protein localization 157 9.60e-01 -2.33e-03 9.90e-01
Alpha-protein kinase 1 signaling pathway 11 9.89e-01 -2.31e-03 9.97e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 9.92e-01 2.30e-03 9.97e-01
Selenoamino acid metabolism 115 9.66e-01 2.29e-03 9.90e-01
RHO GTPase cycle 412 9.43e-01 2.04e-03 9.86e-01
RUNX2 regulates osteoblast differentiation 21 9.87e-01 1.99e-03 9.96e-01
Defective B3GALTL causes PpS 27 9.86e-01 -1.91e-03 9.96e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 9.89e-01 1.58e-03 9.97e-01
Transport and synthesis of PAPS 6 9.95e-01 1.46e-03 9.97e-01
Induction of Cell-Cell Fusion 8 9.95e-01 -1.32e-03 9.97e-01
Synthesis of DNA 108 9.83e-01 -1.17e-03 9.95e-01
SHC-mediated cascade:FGFR4 11 9.95e-01 1.03e-03 9.97e-01
FLT3 Signaling 38 9.91e-01 -1.02e-03 9.97e-01
RMTs methylate histone arginines 35 9.92e-01 9.98e-04 9.97e-01
Late Phase of HIV Life Cycle 131 9.87e-01 -7.94e-04 9.96e-01
HDL remodeling 6 9.98e-01 -6.21e-04 9.99e-01
Viral mRNA Translation 88 9.94e-01 4.98e-04 9.97e-01
HDL assembly 6 9.99e-01 4.24e-04 9.99e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 9.96e-01 2.95e-04 9.97e-01
Nonsense-Mediated Decay (NMD) 114 9.96e-01 2.95e-04 9.97e-01
SARS-CoV-2 Infection 267 9.94e-01 2.74e-04 9.97e-01
Metabolism 1835 9.84e-01 2.74e-04 9.95e-01
Diseases of glycosylation 109 9.99e-01 -4.53e-05 9.99e-01


Detailed Gene set reports



Formation of the ureteric bud
set Formation of the ureteric bud
setSize 5
pANOVA 0.00142
s.dist 0.824
p.adjustANOVA 0.0339


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXC1 10223
WNT11 9487
RET 7926
GREM1 7769
ITGB1 6173

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All member genes
GeneID Gene Rank
FOXC1 10223
WNT11 9487
RET 7926
GREM1 7769
ITGB1 6173


CD163 mediating an anti-inflammatory response
set CD163 mediating an anti-inflammatory response
setSize 9
pANOVA 9.37e-05
s.dist 0.752
p.adjustANOVA 0.00355


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD163 10250
ADAM17 9713
RHBDF2 9629
FURIN 9002
IL10 8866
MYH9 8162
PLK2 5596
IL6 4947
MAPK14 1556

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All member genes
GeneID Gene Rank
CD163 10250
ADAM17 9713
RHBDF2 9629
FURIN 9002
IL10 8866
MYH9 8162
PLK2 5596
IL6 4947
MAPK14 1556


Protein repair
set Protein repair
setSize 6
pANOVA 0.0017
s.dist 0.74
p.adjustANOVA 0.038


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSRB3 8941
TXN 8504
MSRB2 8276
PCMT1 7077
MSRB1 6253
MSRA 5315

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All member genes
GeneID Gene Rank
MSRB3 8941
TXN 8504
MSRB2 8276
PCMT1 7077
MSRB1 6253
MSRA 5315


MECP2 regulates transcription of neuronal ligands
set MECP2 regulates transcription of neuronal ligands
setSize 5
pANOVA 0.00453
s.dist -0.733
p.adjustANOVA 0.0708


Top enriched genes
Top 20 genes
GeneID Gene Rank
HDAC1 -11446
MECP2 -9602
SIN3A -8347
DLL1 -7885
CREB1 -6732

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All member genes
GeneID Gene Rank
HDAC1 -11446
MECP2 -9602
SIN3A -8347
DLL1 -7885
CREB1 -6732


Defective binding of VWF variant to GPIb:IX:V
set Defective binding of VWF variant to GPIb:IX:V
setSize 7
pANOVA 0.000904
s.dist 0.724
p.adjustANOVA 0.0239


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP9 9506
COL1A1 8986
GP1BB 8844
VWF 8432
GP1BA 7170
COL1A2 5629
GP5 1988

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All member genes
GeneID Gene Rank
GP9 9506
COL1A1 8986
GP1BB 8844
VWF 8432
GP1BA 7170
COL1A2 5629
GP5 1988


Enhanced binding of GP1BA variant to VWF multimer:collagen
set Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize 7
pANOVA 0.000904
s.dist 0.724
p.adjustANOVA 0.0239


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP9 9506
COL1A1 8986
GP1BB 8844
VWF 8432
GP1BA 7170
COL1A2 5629
GP5 1988

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All member genes
GeneID Gene Rank
GP9 9506
COL1A1 8986
GP1BB 8844
VWF 8432
GP1BA 7170
COL1A2 5629
GP5 1988


Tandem pore domain potassium channels
set Tandem pore domain potassium channels
setSize 5
pANOVA 0.0075
s.dist -0.69
p.adjustANOVA 0.0934


Top enriched genes
Top 20 genes
GeneID Gene Rank
KCNK6 -11332
KCNK10 -11174
KCNK17 -8317
KCNK13 -6621
KCNK7 -4232

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All member genes
GeneID Gene Rank
KCNK6 -11332
KCNK10 -11174
KCNK17 -8317
KCNK13 -6621
KCNK7 -4232


FASTK family proteins regulate processing and stability of mitochondrial RNAs
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 19
pANOVA 2.15e-07
s.dist 0.687
p.adjustANOVA 1.39e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR2 9583
MT-ND1 9474
MT-ND2 9404
MT-RNR1 9249
MT-ND5 9069
MT-CYB 9007
MT-ND4 8813
MT-ATP6 8600
TBRG4 8462
MT-CO2 8379
FASTKD5 8254
MT-ND3 8131
MT-ND4L 7596
MT-CO3 7529
MT-ND6 7486
MT-CO1 7481
MT-ATP8 2308
FASTK -1948
FASTKD2 -7524

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All member genes
GeneID Gene Rank
MT-RNR2 9583
MT-ND1 9474
MT-ND2 9404
MT-RNR1 9249
MT-ND5 9069
MT-CYB 9007
MT-ND4 8813
MT-ATP6 8600
TBRG4 8462
MT-CO2 8379
FASTKD5 8254
MT-ND3 8131
MT-ND4L 7596
MT-CO3 7529
MT-ND6 7486
MT-CO1 7481
MT-ATP8 2308
FASTK -1948
FASTKD2 -7524


RUNX1 regulates transcription of genes involved in BCR signaling
set RUNX1 regulates transcription of genes involved in BCR signaling
setSize 6
pANOVA 0.00368
s.dist 0.685
p.adjustANOVA 0.0651


Top enriched genes
Top 20 genes
GeneID Gene Rank
ELF1 9009
BLK 8508
ELF2 6435
PAX5 5756
RUNX1 5720
CBFB 5290

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All member genes
GeneID Gene Rank
ELF1 9009
BLK 8508
ELF2 6435
PAX5 5756
RUNX1 5720
CBFB 5290


G2 Phase
set G2 Phase
setSize 5
pANOVA 0.0182
s.dist 0.61
p.adjustANOVA 0.164


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCNA1 10050
E2F3 9952
E2F1 6459
CCNA2 3991
CDK2 -645

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All member genes
GeneID Gene Rank
CCNA1 10050
E2F3 9952
E2F1 6459
CCNA2 3991
CDK2 -645


Propionyl-CoA catabolism
set Propionyl-CoA catabolism
setSize 5
pANOVA 0.0183
s.dist -0.609
p.adjustANOVA 0.164


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCEE -10315
PCCA -9841
MMAA -9214
MMUT -4836
PCCB -2997

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All member genes
GeneID Gene Rank
MCEE -10315
PCCA -9841
MMAA -9214
MMUT -4836
PCCB -2997


Mitochondrial RNA degradation
set Mitochondrial RNA degradation
setSize 25
pANOVA 1.91e-07
s.dist 0.602
p.adjustANOVA 1.37e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
SUPV3L1 9775
MT-RNR2 9583
MT-ND1 9474
MT-ND2 9404
MT-RNR1 9249
MT-ND5 9069
MT-CYB 9007
MT-ND4 8813
MT-ATP6 8600
TBRG4 8462
MT-CO2 8379
FASTKD5 8254
MT-ND3 8131
MT-ND4L 7596
MT-CO3 7529
MT-ND6 7486
MT-CO1 7481
GRSF1 5527
SLIRP 5292
PNPT1 5002

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUPV3L1 9775
MT-RNR2 9583
MT-ND1 9474
MT-ND2 9404
MT-RNR1 9249
MT-ND5 9069
MT-CYB 9007
MT-ND4 8813
MT-ATP6 8600
TBRG4 8462
MT-CO2 8379
FASTKD5 8254
MT-ND3 8131
MT-ND4L 7596
MT-CO3 7529
MT-ND6 7486
MT-CO1 7481
GRSF1 5527
SLIRP 5292
PNPT1 5002
MT-ATP8 2308
LRPPRC 1009
FASTK -1948
FASTKD2 -7524
REXO2 -9271


G2/M DNA replication checkpoint
set G2/M DNA replication checkpoint
setSize 5
pANOVA 0.021
s.dist 0.596
p.adjustANOVA 0.177


Top enriched genes
Top 20 genes
GeneID Gene Rank
WEE1 9887
PKMYT1 5895
CCNB2 5562
CCNB1 4998
CDK1 2712

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WEE1 9887
PKMYT1 5895
CCNB2 5562
CCNB1 4998
CDK1 2712


Translocation of ZAP-70 to Immunological synapse
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 4.6e-07
s.dist -0.594
p.adjustANOVA 2.54e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
TRAC -11472
CD4 -11454
HLA-DPA1 -11289
HLA-DRA -11061
HLA-DQA1 -10882
LCK -10848
HLA-DPB1 -10580
TRAV8-4 -10222
TRBV7-9 -10211
TRBC1 -10019
HLA-DRB1 -9924
ZAP70 -9540
TRAV19 -9145
TRAV29DV5 -9053
HLA-DQB2 -8944
HLA-DRB5 -8498
CD247 -8429
PTPN22 -7211
TRBV12-3 -6591
HLA-DQB1 -3835

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRAC -11472
CD4 -11454
HLA-DPA1 -11289
HLA-DRA -11061
HLA-DQA1 -10882
LCK -10848
HLA-DPB1 -10580
TRAV8-4 -10222
TRBV7-9 -10211
TRBC1 -10019
HLA-DRB1 -9924
ZAP70 -9540
TRAV19 -9145
TRAV29DV5 -9053
HLA-DQB2 -8944
HLA-DRB5 -8498
CD247 -8429
PTPN22 -7211
TRBV12-3 -6591
HLA-DQB1 -3835
CD3E -355
HLA-DQA2 -278
CD3D 6489
CD3G 8789


Biosynthesis of Lipoxins (LX)
set Biosynthesis of Lipoxins (LX)
setSize 6
pANOVA 0.0119
s.dist 0.593
p.adjustANOVA 0.125


Top enriched genes
Top 20 genes
GeneID Gene Rank
HPGD 10037
ALOX5AP 9843
ALOX12 8705
ALOX5 7810
PTGR1 3872
LTC4S -5600

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All member genes
GeneID Gene Rank
HPGD 10037
ALOX5AP 9843
ALOX12 8705
ALOX5 7810
PTGR1 3872
LTC4S -5600


Replacement of protamines by nucleosomes in the male pronucleus
set Replacement of protamines by nucleosomes in the male pronucleus
setSize 13
pANOVA 0.000291
s.dist 0.58
p.adjustANOVA 0.00954


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC9 9901
H2BC4 9809
H2BC21 9790
H2BC11 9781
H2BC12 9601
H2BC5 9491
H2BC17 9385
H2BC15 9295
H3-3A 7362
METTL23 325
NPM2 -272
SRPK1 -2771
HIRA -8418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC9 9901
H2BC4 9809
H2BC21 9790
H2BC11 9781
H2BC12 9601
H2BC5 9491
H2BC17 9385
H2BC15 9295
H3-3A 7362
METTL23 325
NPM2 -272
SRPK1 -2771
HIRA -8418


LTC4-CYSLTR mediated IL4 production
set LTC4-CYSLTR mediated IL4 production
setSize 5
pANOVA 0.0249
s.dist -0.579
p.adjustANOVA 0.19


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYSLTR2 -11633
CYSLTR1 -10976
GGT5 -8784
DPEP2 -3185
GGT1 -969

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All member genes
GeneID Gene Rank
CYSLTR2 -11633
CYSLTR1 -10976
GGT5 -8784
DPEP2 -3185
GGT1 -969


tRNA processing in the mitochondrion
set tRNA processing in the mitochondrion
setSize 24
pANOVA 1.57e-06
s.dist 0.566
p.adjustANOVA 7.41e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR2 9583
MT-ND1 9474
MT-ND2 9404
MT-RNR1 9249
MT-ND5 9069
MT-CYB 9007
MT-ND4 8813
MT-ATP6 8600
MT-CO2 8379
MT-ND3 8131
PRORP 8022
MT-ND4L 7596
MT-CO3 7529
MT-ND6 7486
MT-CO1 7481
MT-TA 5636
MT-TC 4735
ELAC2 2659
MT-ATP8 2308
MT-TP 1787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR2 9583
MT-ND1 9474
MT-ND2 9404
MT-RNR1 9249
MT-ND5 9069
MT-CYB 9007
MT-ND4 8813
MT-ATP6 8600
MT-CO2 8379
MT-ND3 8131
PRORP 8022
MT-ND4L 7596
MT-CO3 7529
MT-ND6 7486
MT-CO1 7481
MT-TA 5636
MT-TC 4735
ELAC2 2659
MT-ATP8 2308
MT-TP 1787
TRMT10C 565
HSD17B10 -2666
MT-TN -2871
TRNT1 -8504


Defects of platelet adhesion to exposed collagen
set Defects of platelet adhesion to exposed collagen
setSize 8
pANOVA 0.00578
s.dist 0.563
p.adjustANOVA 0.0805


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP9 9506
COL1A1 8986
GP1BB 8844
VWF 8432
GP1BA 7170
COL1A2 5629
GP5 1988
ADAMTS13 -6927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP9 9506
COL1A1 8986
GP1BB 8844
VWF 8432
GP1BA 7170
COL1A2 5629
GP5 1988
ADAMTS13 -6927


Formation of xylulose-5-phosphate
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.03
s.dist -0.56
p.adjustANOVA 0.207


Top enriched genes
Top 20 genes
GeneID Gene Rank
SORD -11425
XYLB -7021
CRYL1 -6765
AKR1A1 -6168
DCXR -3144

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SORD -11425
XYLB -7021
CRYL1 -6765
AKR1A1 -6168
DCXR -3144


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.00608
s.dist -0.56
p.adjustANOVA 0.0827


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLB -11224
PARP2 -10426
PARG -10264
LIG1 -9884
APEX1 -7617
FEN1 -4116
ADPRS -2712
PARP1 1037

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLB -11224
PARP2 -10426
PARG -10264
LIG1 -9884
APEX1 -7617
FEN1 -4116
ADPRS -2712
PARP1 1037


APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
set APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
setSize 7
pANOVA 0.0104
s.dist -0.559
p.adjustANOVA 0.116


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLB -11224
XRCC1 -9771
PNKP -9454
LIG3 -8971
OGG1 -7432
NEIL1 -1595
NEIL2 219

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLB -11224
XRCC1 -9771
PNKP -9454
LIG3 -8971
OGG1 -7432
NEIL1 -1595
NEIL2 219


Defective LFNG causes SCDO3
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0334
s.dist -0.549
p.adjustANOVA 0.22


Top enriched genes
Top 20 genes
GeneID Gene Rank
LFNG -11532
NOTCH1 -9709
NOTCH2 -9618
NOTCH4 -6000
NOTCH3 2950

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LFNG -11532
NOTCH1 -9709
NOTCH2 -9618
NOTCH4 -6000
NOTCH3 2950


RHOT1 GTPase cycle
set RHOT1 GTPase cycle
setSize 5
pANOVA 0.0351
s.dist 0.544
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAP1GDS1 9920
TRAK2 9839
RHOT1 8521
MYO19 3801
TRAK1 -5874

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAP1GDS1 9920
TRAK2 9839
RHOT1 8521
MYO19 3801
TRAK1 -5874


Synthesis of PI
set Synthesis of PI
setSize 5
pANOVA 0.0401
s.dist -0.53
p.adjustANOVA 0.248


Top enriched genes
Top 20 genes
GeneID Gene Rank
PITPNM1 -10090
PITPNM3 -9803
CDS1 -9726
CDIPT -6974
PITPNM2 3744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PITPNM1 -10090
PITPNM3 -9803
CDS1 -9726
CDIPT -6974
PITPNM2 3744


NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
set NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
setSize 8
pANOVA 0.01
s.dist -0.526
p.adjustANOVA 0.113


Top enriched genes
Top 20 genes
GeneID Gene Rank
NR1H3 -11214
RXRA -11159
SREBF1 -10748
RXRB -9490
FASN -5309
NR1H2 -2714
NRIP1 -2255
SCD 719

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NR1H3 -11214
RXRA -11159
SREBF1 -10748
RXRB -9490
FASN -5309
NR1H2 -2714
NRIP1 -2255
SCD 719


Interleukin-21 signaling
set Interleukin-21 signaling
setSize 9
pANOVA 0.00718
s.dist -0.517
p.adjustANOVA 0.0906


Top enriched genes
Top 20 genes
GeneID Gene Rank
IL21R -11518
IL2RG -10511
STAT5B -10176
STAT1 -9595
STAT5A -9235
STAT4 -8530
JAK3 -5125
JAK1 982
STAT3 5827

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL21R -11518
IL2RG -10511
STAT5B -10176
STAT1 -9595
STAT5A -9235
STAT4 -8530
JAK3 -5125
JAK1 982
STAT3 5827


Phenylalanine metabolism
set Phenylalanine metabolism
setSize 5
pANOVA 0.0454
s.dist -0.517
p.adjustANOVA 0.268


Top enriched genes
Top 20 genes
GeneID Gene Rank
ASRGL1 -11730
IL4I1 -11301
KYAT1 -9449
QDPR -4707
PCBD1 5067

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ASRGL1 -11730
IL4I1 -11301
KYAT1 -9449
QDPR -4707
PCBD1 5067


CD22 mediated BCR regulation
set CD22 mediated BCR regulation
setSize 58
pANOVA 1.38e-11
s.dist 0.513
p.adjustANOVA 1.33e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGHV2-5 9496
IGLV1-44 9274
IGHV3-13 8920
IGKV2-30 8855
IGKV1-33 8632
IGLV2-23 8572
IGLV1-51 8040
IGLC1 8028
IGHV3-7 7999
IGKC 7992
IGHM 7963
IGKV1-16 7834
IGHV3-23 7825
IGKV3-11 7777
CD79A 7656
IGHV3-48 7436
IGHV4-34 7264
IGHV3-53 7239
IGKV4-1 7198
IGHV3-33 7062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHV2-5 9496
IGLV1-44 9274
IGHV3-13 8920
IGKV2-30 8855
IGKV1-33 8632
IGLV2-23 8572
IGLV1-51 8040
IGLC1 8028
IGHV3-7 7999
IGKC 7992
IGHM 7963
IGKV1-16 7834
IGHV3-23 7825
IGKV3-11 7777
CD79A 7656
IGHV3-48 7436
IGHV4-34 7264
IGHV3-53 7239
IGKV4-1 7198
IGHV3-33 7062
IGHD 6938
IGLC3 6463
IGKV3-15 6448
IGHV1-2 6404
IGLV3-19 6395
IGKV1-5 6277
IGHV1-69 6195
IGKV1-12 6190
IGHV4-59 6149
IGLV2-11 5949
IGKV1D-39 5687
IGKV1-17 5671
IGLC2 5627
IGLV1-40 5424
IGHV3-11 5410
IGLV7-43 5302
CD22 5017
IGHV1-46 4928
IGLV3-27 4893
IGKV2-28 4813
IGKV3-20 4802
IGLC7 4719
IGKV2-29 4496
IGLV2-8 4281
IGHV2-70 4047
IGKV2D-28 3127
IGLV6-57 1732
IGHV3-30 1440
IGLV3-25 1261
IGKV3D-20 870
IGHV4-39 104
IGLV2-14 -1537
IGLV1-47 -2102
PTPN6 -2252
IGLV3-21 -2657
CD79B -4023
IGLV3-1 -5593
LYN -6611


Estrogen-stimulated signaling through PRKCZ
set Estrogen-stimulated signaling through PRKCZ
setSize 6
pANOVA 0.0302
s.dist 0.511
p.adjustANOVA 0.208


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 9974
PDPK1 9315
NRAS 7606
PRKCZ 5489
KRAS -1426
HRAS -1703

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 9974
PDPK1 9315
NRAS 7606
PRKCZ 5489
KRAS -1426
HRAS -1703


RNA Polymerase I Promoter Opening
set RNA Polymerase I Promoter Opening
setSize 17
pANOVA 0.000301
s.dist 0.506
p.adjustANOVA 0.00968


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC9 9901.0
H2AC6 9891.0
H2BC4 9809.0
H2BC21 9790.0
H2BC11 9781.0
H2BC12 9601.0
H2BC5 9491.0
H2BC17 9385.0
H2BC15 9295.0
MBD2 8407.0
H3-3A 7362.0
H2AJ 3819.0
MAPK3 1078.0
H3C15 -2477.5
H2AC20 -2501.0
H2AZ2 -9940.0
UBTF -10702.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC9 9901.0
H2AC6 9891.0
H2BC4 9809.0
H2BC21 9790.0
H2BC11 9781.0
H2BC12 9601.0
H2BC5 9491.0
H2BC17 9385.0
H2BC15 9295.0
MBD2 8407.0
H3-3A 7362.0
H2AJ 3819.0
MAPK3 1078.0
H3C15 -2477.5
H2AC20 -2501.0
H2AZ2 -9940.0
UBTF -10702.0


PD-1 signaling
set PD-1 signaling
setSize 28
pANOVA 3.73e-06
s.dist -0.505
p.adjustANOVA 0.000171


Top enriched genes
Top 20 genes
GeneID Gene Rank
TRAC -11472
CD274 -11469
CD4 -11454
HLA-DPA1 -11289
HLA-DRA -11061
HLA-DQA1 -10882
LCK -10848
HLA-DPB1 -10580
TRAV8-4 -10222
TRBV7-9 -10211
TRBC1 -10019
HLA-DRB1 -9924
CSK -9198
TRAV19 -9145
TRAV29DV5 -9053
HLA-DQB2 -8944
PDCD1LG2 -8566
HLA-DRB5 -8498
CD247 -8429
TRBV12-3 -6591

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRAC -11472
CD274 -11469
CD4 -11454
HLA-DPA1 -11289
HLA-DRA -11061
HLA-DQA1 -10882
LCK -10848
HLA-DPB1 -10580
TRAV8-4 -10222
TRBV7-9 -10211
TRBC1 -10019
HLA-DRB1 -9924
CSK -9198
TRAV19 -9145
TRAV29DV5 -9053
HLA-DQB2 -8944
PDCD1LG2 -8566
HLA-DRB5 -8498
CD247 -8429
TRBV12-3 -6591
HLA-DQB1 -3835
PTPN6 -2252
CD3E -355
HLA-DQA2 -278
PTPN11 3774
CD3D 6489
CD3G 8789
PDCD1 9420


Coenzyme A biosynthesis
set Coenzyme A biosynthesis
setSize 7
pANOVA 0.0212
s.dist -0.503
p.adjustANOVA 0.178


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPCDC -11413
PPCS -9429
DCAKD -8956
PANK2 -8889
PANK1 -4888
COASY -3560
PANK3 3225

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPCDC -11413
PPCS -9429
DCAKD -8956
PANK2 -8889
PANK1 -4888
COASY -3560
PANK3 3225


YAP1- and WWTR1 (TAZ)-stimulated gene expression
set YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize 7
pANOVA 0.0218
s.dist 0.501
p.adjustANOVA 0.179


Top enriched genes
Top 20 genes
GeneID Gene Rank
HIPK2 9989
RUNX2 9113
WWTR1 7200
HIPK1 5503
NPPA 5335
KAT2B 3563
TEAD2 -7359

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIPK2 9989
RUNX2 9113
WWTR1 7200
HIPK1 5503
NPPA 5335
KAT2B 3563
TEAD2 -7359


Chromatin modifications during the maternal to zygotic transition (MZT)
set Chromatin modifications during the maternal to zygotic transition (MZT)
setSize 23
pANOVA 3.24e-05
s.dist 0.501
p.adjustANOVA 0.00139


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC9 9901.0
H2AC6 9891.0
H2BC4 9809.0
H2BC21 9790.0
H2BC11 9781.0
H2BC12 9601.0
H2BC5 9491.0
H2BC17 9385.0
H2BC15 9295.0
AICDA 9106.0
UNG 8956.0
TET3 8724.0
H3-3A 7362.0
KDM6A 6697.0
KDM5B 6490.0
UHRF1 4591.0
H2AJ 3819.0
METTL23 325.0
H3C15 -2477.5
H2AC20 -2501.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC9 9901.0
H2AC6 9891.0
H2BC4 9809.0
H2BC21 9790.0
H2BC11 9781.0
H2BC12 9601.0
H2BC5 9491.0
H2BC17 9385.0
H2BC15 9295.0
AICDA 9106.0
UNG 8956.0
TET3 8724.0
H3-3A 7362.0
KDM6A 6697.0
KDM5B 6490.0
UHRF1 4591.0
H2AJ 3819.0
METTL23 325.0
H3C15 -2477.5
H2AC20 -2501.0
KDM5A -9022.0
KDM6B -9649.0
H2AZ2 -9940.0


ATF6 (ATF6-alpha) activates chaperone genes
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.00621
s.dist 0.5
p.adjustANOVA 0.0827


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 9387
ATF6 8441
NFYC 8420
CALR 8046
ATF4 8024
HSP90B1 6348
XBP1 6331
DDIT3 5505
NFYA -2921
NFYB -10059

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 9387
ATF6 8441
NFYC 8420
CALR 8046
ATF4 8024
HSP90B1 6348
XBP1 6331
DDIT3 5505
NFYA -2921
NFYB -10059


Phosphorylation of CD3 and TCR zeta chains
set Phosphorylation of CD3 and TCR zeta chains
setSize 27
pANOVA 7.01e-06
s.dist -0.499
p.adjustANOVA 0.000315


Top enriched genes
Top 20 genes
GeneID Gene Rank
TRAC -11472
CD4 -11454
HLA-DPA1 -11289
HLA-DRA -11061
HLA-DQA1 -10882
LCK -10848
HLA-DPB1 -10580
TRAV8-4 -10222
TRBV7-9 -10211
PTPRC -10106
TRBC1 -10019
HLA-DRB1 -9924
CSK -9198
TRAV19 -9145
TRAV29DV5 -9053
HLA-DQB2 -8944
HLA-DRB5 -8498
CD247 -8429
PTPN22 -7211
TRBV12-3 -6591

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRAC -11472
CD4 -11454
HLA-DPA1 -11289
HLA-DRA -11061
HLA-DQA1 -10882
LCK -10848
HLA-DPB1 -10580
TRAV8-4 -10222
TRBV7-9 -10211
PTPRC -10106
TRBC1 -10019
HLA-DRB1 -9924
CSK -9198
TRAV19 -9145
TRAV29DV5 -9053
HLA-DQB2 -8944
HLA-DRB5 -8498
CD247 -8429
PTPN22 -7211
TRBV12-3 -6591
HLA-DQB1 -3835
CD3E -355
HLA-DQA2 -278
PTPRJ 6280
CD3D 6489
CD3G 8789
PAG1 9859


Response to metal ions
set Response to metal ions
setSize 6
pANOVA 0.0354
s.dist 0.496
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT2A 10010
MT1E 9407
MT1X 8218
MT1F 5471
CSRP1 4720
MTF1 -9553

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT2A 10010
MT1E 9407
MT1X 8218
MT1F 5471
CSRP1 4720
MTF1 -9553


Acetylcholine Neurotransmitter Release Cycle
set Acetylcholine Neurotransmitter Release Cycle
setSize 11
pANOVA 0.00449
s.dist -0.495
p.adjustANOVA 0.0708


Top enriched genes
Top 20 genes
GeneID Gene Rank
STXBP1 -11029
PPFIA4 -10847
TSPOAP1 -9401
VAMP2 -8968
RAB3A -8451
STX1A -7261
UNC13B -6452
CPLX1 -5911
PPFIA3 -3176
PPFIA1 -175
SYT1 3675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STXBP1 -11029
PPFIA4 -10847
TSPOAP1 -9401
VAMP2 -8968
RAB3A -8451
STX1A -7261
UNC13B -6452
CPLX1 -5911
PPFIA3 -3176
PPFIA1 -175
SYT1 3675


Signal attenuation
set Signal attenuation
setSize 9
pANOVA 0.011
s.dist 0.49
p.adjustANOVA 0.118


Top enriched genes
Top 20 genes
GeneID Gene Rank
INSR 10249
GRB10 10232
IRS2 9983
MAPK1 9974
IRS1 6488
GRB2 2051
MAPK3 1078
SHC1 218
SOS1 -8493

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INSR 10249
GRB10 10232
IRS2 9983
MAPK1 9974
IRS1 6488
GRB2 2051
MAPK3 1078
SHC1 218
SOS1 -8493


Estrogen biosynthesis
set Estrogen biosynthesis
setSize 5
pANOVA 0.059
s.dist 0.488
p.adjustANOVA 0.306


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSD17B2 9886
CYP19A1 7900
HSD17B11 5881
AKR1B15 5188
HSD17B1 -5754

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSD17B2 9886
CYP19A1 7900
HSD17B11 5881
AKR1B15 5188
HSD17B1 -5754


MET activates RAP1 and RAC1
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.00791
s.dist 0.485
p.adjustANOVA 0.0961


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAP1A 9535
HGF 8972
GAB1 8860
RAP1B 8490
CRKL 4497
CRK 3517
RAC1 3237
GRB2 2051
RAPGEF1 -22
DOCK7 -3232

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAP1A 9535
HGF 8972
GAB1 8860
RAP1B 8490
CRKL 4497
CRK 3517
RAC1 3237
GRB2 2051
RAPGEF1 -22
DOCK7 -3232


Carnitine shuttle
set Carnitine shuttle
setSize 12
pANOVA 0.00382
s.dist -0.482
p.adjustANOVA 0.0659


Top enriched genes
Top 20 genes
GeneID Gene Rank
RXRA -11159
SLC22A5 -11051
SLC25A20 -10349
PPARD -10150
MID1IP1 -7974
CPT2 -7752
CPT1A -7181
CPT1B -5570
ACACA -2984
PRKAB2 -1257
ACACB -424
PRKAG2 3336

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RXRA -11159
SLC22A5 -11051
SLC25A20 -10349
PPARD -10150
MID1IP1 -7974
CPT2 -7752
CPT1A -7181
CPT1B -5570
ACACA -2984
PRKAB2 -1257
ACACB -424
PRKAG2 3336


Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
set Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
setSize 12
pANOVA 0.00389
s.dist 0.481
p.adjustANOVA 0.0659


Top enriched genes
Top 20 genes
GeneID Gene Rank
TPST1 10175
GP9 9506
GP1BB 8844
VWF 8432
GP1BA 7170
F12 7033
TPST2 4924
KLKB1 4318
GGCX 3287
GP5 1988
F8 -5010
SERPING1 -6081

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPST1 10175
GP9 9506
GP1BB 8844
VWF 8432
GP1BA 7170
F12 7033
TPST2 4924
KLKB1 4318
GGCX 3287
GP5 1988
F8 -5010
SERPING1 -6081


ATF6 (ATF6-alpha) activates chaperones
set ATF6 (ATF6-alpha) activates chaperones
setSize 12
pANOVA 0.00409
s.dist 0.479
p.adjustANOVA 0.068


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 9387
ATF6 8441
NFYC 8420
CALR 8046
ATF4 8024
MBTPS2 7826
HSP90B1 6348
XBP1 6331
DDIT3 5505
MBTPS1 -1102
NFYA -2921
NFYB -10059

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 9387
ATF6 8441
NFYC 8420
CALR 8046
ATF4 8024
MBTPS2 7826
HSP90B1 6348
XBP1 6331
DDIT3 5505
MBTPS1 -1102
NFYA -2921
NFYB -10059


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.0284
s.dist 0.478
p.adjustANOVA 0.201


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLR2 10167
UBC 8371
MRC1 7355
B2M 5647
UBA52 3637
UBB 147
RPS27A -3694

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 10167
UBC 8371
MRC1 7355
B2M 5647
UBA52 3637
UBB 147
RPS27A -3694


RUNX1 regulates expression of components of tight junctions
set RUNX1 regulates expression of components of tight junctions
setSize 5
pANOVA 0.064
s.dist 0.478
p.adjustANOVA 0.321


Top enriched genes
Top 20 genes
GeneID Gene Rank
CLDN5 9964
RUNX1 5720
CBFB 5290
TJP1 4993
OCLN -3379

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLDN5 9964
RUNX1 5720
CBFB 5290
TJP1 4993
OCLN -3379


Formation of the active cofactor, UDP-glucuronate
set Formation of the active cofactor, UDP-glucuronate
setSize 5
pANOVA 0.0668
s.dist 0.473
p.adjustANOVA 0.325


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC35D2 9574
UGDH 8650
UGP2 8611
SLC35D1 5485
UXS1 -10002

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC35D2 9574
UGDH 8650
UGP2 8611
SLC35D1 5485
UXS1 -10002


Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
set Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
setSize 20
pANOVA 0.000264
s.dist 0.471
p.adjustANOVA 0.00879


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC9 9901.0
H2AC6 9891.0
H2BC4 9809.0
H2BC21 9790.0
H2BC11 9781.0
H2BC12 9601.0
H2BC5 9491.0
H2BC17 9385.0
H2BC15 9295.0
KLK2 8190.0
H3-3A 7362.0
AR 5543.0
H2AJ 3819.0
PKN1 2693.0
KDM4C -1609.0
H3C15 -2477.5
H2AC20 -2501.0
NCOA2 -4536.0
KDM1A -4770.0
H2AZ2 -9940.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC9 9901.0
H2AC6 9891.0
H2BC4 9809.0
H2BC21 9790.0
H2BC11 9781.0
H2BC12 9601.0
H2BC5 9491.0
H2BC17 9385.0
H2BC15 9295.0
KLK2 8190.0
H3-3A 7362.0
AR 5543.0
H2AJ 3819.0
PKN1 2693.0
KDM4C -1609.0
H3C15 -2477.5
H2AC20 -2501.0
NCOA2 -4536.0
KDM1A -4770.0
H2AZ2 -9940.0


RUNX3 regulates BCL2L11 (BIM) transcription
set RUNX3 regulates BCL2L11 (BIM) transcription
setSize 5
pANOVA 0.0712
s.dist 0.466
p.adjustANOVA 0.334


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXO3 10225
BCL2L11 8726
RUNX3 7442
SMAD3 -1267
SMAD4 -3216

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXO3 10225
BCL2L11 8726
RUNX3 7442
SMAD3 -1267
SMAD4 -3216


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3`
## [1] "H2AC6"  "H2BC11" "H2BC12" "H2BC15" "H2BC17" "H2BC21" "H2BC4"  "H2BC5" 
## [9] "H2BC9" 
## 
## [[1]]$`UP genesets.CD163 mediating an anti-inflammatory response`
## [1] "ADAM17" "CD163"  "FURIN"  "IL10"   "RHBDF2"
## 
## [[1]]$`UP genesets.CD22 mediated BCR regulation`
## [1] "IGHV2-5"  "IGHV3-13" "IGKV1-33" "IGKV2-30" "IGLV1-44" "IGLV2-23"
## 
## [[1]]$`UP genesets.Chromatin modifications during the maternal to zygotic transition (MZT)`
##  [1] "AICDA"  "H2AC6"  "H2BC11" "H2BC12" "H2BC15" "H2BC17" "H2BC21" "H2BC4" 
##  [9] "H2BC5"  "H2BC9"  "TET3"   "UNG"   
## 
## [[1]]$`UP genesets.Classical antibody-mediated complement activation`
##  [1] "C1QB"      "IGHV2-5"   "IGHV3-13"  "IGKV1-33"  "IGKV2-30"  "IGLV1-44" 
##  [7] "IGLV10-54" "IGLV2-18"  "IGLV2-23"  "IGLV4-69" 
## 
## [[1]]$`UP genesets.Creation of C4 and C2 activators`
##  [1] "C1QB"      "IGHV2-5"   "IGHV3-13"  "IGKV1-33"  "IGKV2-30"  "IGLV1-44" 
##  [7] "IGLV10-54" "IGLV2-18"  "IGLV2-23"  "IGLV4-69" 
## 
## [[1]]$`UP genesets.Defective binding of VWF variant to GPIb:IX:V`
## [1] "COL1A1" "GP1BB"  "GP9"    "VWF"   
## 
## [[1]]$`UP genesets.Enhanced binding of GP1BA variant to VWF multimer:collagen`
## [1] "COL1A1" "GP1BB"  "GP9"    "VWF"   
## 
## [[1]]$`UP genesets.FASTK family proteins regulate processing and stability of mitochondrial RNAs`
##  [1] "FASTKD5" "MT-ATP6" "MT-CO2"  "MT-CYB"  "MT-ND1"  "MT-ND2"  "MT-ND4" 
##  [8] "MT-ND5"  "MT-RNR1" "MT-RNR2" "TBRG4"  
## 
## [[1]]$`UP genesets.Formation of the ureteric bud`
## [1] "FOXC1" "WNT11"
## 
## [[1]]$`UP genesets.Mitochondrial RNA degradation`
##  [1] "FASTKD5" "MT-ATP6" "MT-CO2"  "MT-CYB"  "MT-ND1"  "MT-ND2"  "MT-ND4" 
##  [8] "MT-ND5"  "MT-RNR1" "MT-RNR2" "SUPV3L1" "TBRG4"  
## 
## [[1]]$`UP genesets.Platelet Adhesion to exposed collagen`
## [1] "COL1A1" "FYN"    "GP1BB"  "GP6"    "GP9"    "ITGA2"  "VWF"   
## 
## [[1]]$`UP genesets.Protein repair`
## [1] "MSRB2" "MSRB3" "TXN"  
## 
## [[1]]$`UP genesets.RHO GTPases activate PKNs`
##  [1] "H2AC6"    "H2BC11"   "H2BC12"   "H2BC15"   "H2BC17"   "H2BC21"  
##  [7] "H2BC4"    "H2BC5"    "H2BC9"    "PDPK1"    "PPP1R14A" "YWHAG"   
## [13] "YWHAQ"    "YWHAZ"   
## 
## [[1]]$`UP genesets.RNA Polymerase I Promoter Opening`
##  [1] "H2AC6"  "H2BC11" "H2BC12" "H2BC15" "H2BC17" "H2BC21" "H2BC4"  "H2BC5" 
##  [9] "H2BC9"  "MBD2"  
## 
## [[1]]$`UP genesets.Replacement of protamines by nucleosomes in the male pronucleus`
## [1] "H2BC11" "H2BC12" "H2BC15" "H2BC17" "H2BC21" "H2BC4"  "H2BC5"  "H2BC9" 
## 
## [[1]]$`UP genesets.Role of LAT2/NTAL/LAB on calcium mobilization`
##  [1] "FYN"       "GAB2"      "IGHV2-5"   "IGHV3-13"  "IGKV1-33"  "IGKV2-30" 
##  [7] "IGLV1-44"  "IGLV10-54" "IGLV2-18"  "IGLV2-23"  "IGLV4-69"  "PDPK1"    
## 
## [[1]]$`UP genesets.Scavenging of heme from plasma`
##  [1] "CD163"     "IGHA1"     "IGHV2-5"   "IGHV3-13"  "IGKV1-33"  "IGKV2-30" 
##  [7] "IGLV1-44"  "IGLV10-54" "IGLV2-18"  "IGLV2-23"  "IGLV4-69" 
## 
## [[1]]$`UP genesets.rRNA processing in the mitochondrion`
## [1] "MT-ATP6" "MT-CO2"  "MT-CYB"  "MT-ND1"  "MT-ND2"  "MT-ND4"  "MT-ND5" 
## [8] "MT-RNR1" "MT-RNR2"
## 
## [[1]]$`UP genesets.tRNA processing in the mitochondrion`
## [1] "MT-ATP6" "MT-CO2"  "MT-CYB"  "MT-ND1"  "MT-ND2"  "MT-ND4"  "MT-ND5" 
## [8] "MT-RNR1" "MT-RNR2"
## 
## [[1]]$`DOWN genesets.Cilium Assembly`
##   [1] "ACTR1A"    "AHI1"      "AKAP9"     "ALMS1"     "ARF4"      "ARL13B"   
##   [7] "ARL3"      "ARL6"      "ASAP1"     "ATAT1"     "B9D1"      "B9D2"     
##  [13] "BBIP1"     "BBS1"      "BBS10"     "BBS12"     "BBS2"      "BBS4"     
##  [19] "BBS5"      "BBS7"      "BBS9"      "C2CD3"     "CC2D2A"    "CCP110"   
##  [25] "CCT2"      "CCT3"      "CCT4"      "CCT5"      "CCT8"      "CDK1"     
##  [31] "CDK5RAP2"  "CENPJ"     "CEP131"    "CEP135"    "CEP152"    "CEP162"   
##  [37] "CEP164"    "CEP192"    "CEP250"    "CEP290"    "CEP41"     "CEP43"    
##  [43] "CEP57"     "CEP63"     "CEP70"     "CEP72"     "CEP76"     "CEP78"    
##  [49] "CEP83"     "CEP89"     "CEP97"     "CETN2"     "CKAP5"     "CLUAP1"   
##  [55] "CNGB1"     "CSNK1D"    "CSNK1E"    "DCTN1"     "DCTN2"     "DCTN3"    
##  [61] "DYNC1H1"   "DYNC1I2"   "DYNC2H1"   "DYNC2I1"   "DYNC2I2"   "DYNC2LI1" 
##  [67] "DYNLL1"    "DYNLL2"    "DYNLT2"    "DYNLT2B"   "DYNLT5"    "EXOC1"    
##  [73] "EXOC2"     "EXOC3"     "EXOC4"     "EXOC5"     "EXOC6"     "EXOC7"    
##  [79] "EXOC8"     "FBF1"      "GBF1"      "HAUS1"     "HAUS2"     "HAUS3"    
##  [85] "HAUS4"     "HAUS5"     "HAUS6"     "HAUS7"     "HAUS8"     "HDAC6"    
##  [91] "HSP90AA1"  "HSPB11"    "IFT122"    "IFT140"    "IFT172"    "IFT20"    
##  [97] "IFT22"     "IFT27"     "IFT43"     "IFT46"     "IFT52"     "IFT74"    
## [103] "IFT80"     "IFT81"     "IFT88"     "INPP5E"    "IQCB1"     "KIF24"    
## [109] "KIF3A"     "KIF3B"     "KIF3C"     "KIFAP3"    "LZTFL1"    "MARK4"    
## [115] "MCHR1"     "MKKS"      "MKS1"      "NDE1"      "NEDD1"     "NEK2"     
## [121] "NPHP3"     "NPHP4"     "ODF2"      "OFD1"      "PAFAH1B1"  "PCM1"     
## [127] "PCNT"      "PDE6D"     "PKD1"      "PKD2"      "PLK1"      "PLK4"     
## [133] "PPP2R1A"   "PRKACA"    "RAB11FIP3" "RAB3IP"    "RAB8A"     "RP2"      
## [139] "RPGRIP1L"  "SCLT1"     "SDCCAG8"   "SEPTIN2"   "SFI1"      "SSNA1"    
## [145] "SSTR3"     "TCP1"      "TCTN1"     "TCTN2"     "TCTN3"     "TMEM216"  
## [151] "TMEM67"    "TNPO1"     "TRAF3IP1"  "TRIP11"    "TTBK2"     "TTC21B"   
## [157] "TTC26"     "TTC8"      "TUBA1A"    "TUBA1B"    "TUBB"      "TUBB2A"   
## [163] "TUBB3"     "TUBB4A"    "TUBB4B"    "TUBB6"     "TUBG1"     "UNC119B"  
## [169] "WDR19"     "WDR35"     "YWHAE"    
## 
## [[1]]$`DOWN genesets.Gene expression (Transcription)`
##    [1] "AAAS"      "ABCA6"     "ABL1"      "ACTB"      "ACTL6A"    "ADRM1"    
##    [7] "AEBP2"     "AFF4"      "AGO1"      "AGO2"      "AGO3"      "AGO4"     
##   [13] "AGPAT2"    "AGRP"      "AIFM2"     "AJUBA"     "AKAP8L"    "AKT1"     
##   [19] "AKT2"      "AKT3"      "ALYREF"    "ANAPC1"    "ANAPC10"   "ANAPC11"  
##   [25] "ANAPC15"   "ANAPC2"    "ANAPC4"    "ANAPC5"    "ANAPC7"    "ANG"      
##   [31] "ANGPTL4"   "APAF1"     "APOE"      "AR"        "ARID1A"    "ARID1B"   
##   [37] "ARID2"     "ARID3A"    "ARID4B"    "ARNT"      "ARNTL"     "ASH2L"    
##   [43] "ATAD2"     "ATF2"      "ATF7IP"    "ATM"       "ATR"       "ATRIP"    
##   [49] "ATXN3"     "AURKA"     "AURKB"     "AUTS2"     "AXIN1"     "BANP"     
##   [55] "BARD1"     "BAX"       "BAZ1B"     "BAZ2A"     "BBC3"      "BCDIN3D"  
##   [61] "BCL2L14"   "BCL6"      "BCL7A"     "BCL7B"     "BCL7C"     "BDP1"     
##   [67] "BGLAP"     "BID"       "BIRC5"     "BMI1"      "BNIP3L"    "BOD1"     
##   [73] "BOD1L1"    "BRCA1"     "BRD1"      "BRD2"      "BRD7"      "BRF1"     
##   [79] "BRF2"      "BRIP1"     "BRPF1"     "BRPF3"     "BTG2"      "C19orf84" 
##   [85] "CALM1"     "CAMK2A"    "CAMK2D"    "CAMK2G"    "CAMK4"     "CARM1"    
##   [91] "CASC3"     "CASP1"     "CASP10"    "CASP2"     "CAT"       "CAV1"     
##   [97] "CBFB"      "CBX2"      "CBX4"      "CBX5"      "CBX6"      "CBX8"     
##  [103] "CCNA2"     "CCNB1"     "CCNC"      "CCND1"     "CCND2"     "CCNE1"    
##  [109] "CCNE2"     "CCNG1"     "CCNG2"     "CCNK"      "CCNT1"     "CCNT2"    
##  [115] "CD36"      "CDC16"     "CDC23"     "CDC25C"    "CDC26"     "CDC27"    
##  [121] "CDC40"     "CDC7"      "CDC73"     "CDK1"      "CDK12"     "CDK13"    
##  [127] "CDK2"      "CDK4"      "CDK5"      "CDK6"      "CDK7"      "CDK8"     
##  [133] "CDK9"      "CDKN1B"    "CDKN2A"    "CEBPA"     "CEBPB"     "CENPJ"    
##  [139] "CHD3"      "CHD4"      "CHEK1"     "CHEK2"     "CHM"       "CHTOP"    
##  [145] "CITED2"    "CITED4"    "CLP1"      "CNOT1"     "CNOT10"    "CNOT11"   
##  [151] "CNOT2"     "CNOT3"     "CNOT4"     "CNOT6"     "CNOT6L"    "CNOT7"    
##  [157] "CNOT8"     "COL1A2"    "COX4I1"    "COX5A"     "COX5B"     "COX6A1"   
##  [163] "COX6B1"    "COX6B2"    "COX6C"     "COX7A1"    "COX7A2"    "COX7A2L"  
##  [169] "COX7B"     "COX7C"     "COX8A"     "CPSF1"     "CPSF2"     "CPSF3"    
##  [175] "CPSF4"     "CPSF6"     "CPSF7"     "CR1"       "CRADD"     "CREB1"    
##  [181] "CREBBP"    "CSF1R"     "CSNK2A1"   "CSNK2A2"   "CSNK2B"    "CSTF1"    
##  [187] "CSTF2"     "CSTF2T"    "CSTF3"     "CTDP1"     "CTNNB1"    "CTR9"     
##  [193] "CTSK"      "CTSL"      "CTSV"      "CUL1"      "CXXC1"     "CYCS"     
##  [199] "DAXX"      "DDB2"      "DDIT3"     "DDX39A"    "DDX39B"    "DEK"      
##  [205] "DGAT2"     "DGCR8"     "DHX38"     "DLL1"      "DLX6"      "DNA2"     
##  [211] "DNMT1"     "DNMT3A"    "DNMT3B"    "DPF2"      "DPF3"      "DPY30"    
##  [217] "DR1"       "DROSHA"    "DYRK2"     "E2F1"      "E2F4"      "E2F5"     
##  [223] "E2F6"      "E2F7"      "E2F8"      "EAF1"      "EAF2"      "EED"      
##  [229] "EHMT1"     "EHMT2"     "EIF4A3"    "ELAC2"     "ELF2"      "ELL"      
##  [235] "ELL3"      "ELOB"      "ELOC"      "ELOVL5"    "EP300"     "EPC1"     
##  [241] "ERBB2"     "ERCC2"     "ERCC3"     "ERCC6"     "ESR1"      "ESR2"     
##  [247] "ESRRA"     "EXO1"      "EZH2"      "FANCC"     "FANCD2"    "FANCI"    
##  [253] "FAS"       "FASLG"     "FIP1L1"    "FKBP6"     "FOS"       "FOXO1"    
##  [259] "FOXO4"     "FYTTD1"    "FZR1"      "G6PC1"     "GAMT"      "GATA2"    
##  [265] "GATA3"     "GATAD2A"   "GATAD2B"   "GCK"       "GLI3"      "GLS"      
##  [271] "GLS2"      "GP1BA"     "GPAM"      "GPI"       "GPRIN1"    "GPS2"     
##  [277] "GPX2"      "GRIN2A"    "GSK3B"     "GTF2A1"    "GTF2A2"    "GTF2B"    
##  [283] "GTF2E1"    "GTF2E2"    "GTF2F1"    "GTF2F2"    "GTF2H1"    "GTF2H2"   
##  [289] "GTF2H3"    "GTF2H4"    "GTF2H5"    "GTF3C1"    "GTF3C2"    "GTF3C3"   
##  [295] "GTF3C4"    "GTF3C5"    "GTF3C6"    "H19"       "H2AC20"    "H2AJ"     
##  [301] "H2AZ2"     "H3-3A"     "H3C15"     "HCFC1"     "HCFC2"     "HDAC1"    
##  [307] "HDAC10"    "HDAC11"    "HDAC2"     "HDAC3"     "HDAC5"     "HDAC6"    
##  [313] "HDAC7"     "HDAC8"     "HDAC9"     "HENMT1"    "HES1"      "HEY1"     
##  [319] "HEY2"      "HIPK1"     "HIVEP3"    "HNF4A"     "HSP90AA1"  "HSPD1"    
##  [325] "HTT"       "HUS1"      "ICE1"      "ICE2"      "IFNG"      "IGFBP3"   
##  [331] "IL6"       "ING2"      "ING5"      "INTS1"     "INTS12"    "INTS2"    
##  [337] "INTS3"     "INTS4"     "INTS5"     "INTS6"     "INTS7"     "INTS8"    
##  [343] "INTS9"     "IPO8"      "IQSEC3"    "IRAK1"     "ITCH"      "ITGA4"    
##  [349] "ITGA5"     "ITGAL"     "IWS1"      "JARID2"    "JMY"       "JUN"      
##  [355] "JUNB"      "KANSL1"    "KANSL2"    "KANSL3"    "KAT14"     "KAT2A"    
##  [361] "KAT2B"     "KAT5"      "KAT6A"     "KAT8"      "KCTD1"     "KCTD15"   
##  [367] "KCTD6"     "KDM5B"     "KDM6A"     "KLF4"      "KMT2A"     "KMT2B"    
##  [373] "KMT2C"     "KMT2D"     "KMT5A"     "KRAS"      "KRBA1"     "KRBOX4"   
##  [379] "L3MBTL1"   "L3MBTL2"   "LAMTOR1"   "LAMTOR2"   "LAMTOR3"   "LAMTOR4"  
##  [385] "LAMTOR5"   "LBR"       "LDB1"      "LEF1"      "LEO1"      "LGALS3"   
##  [391] "LIPE"      "LMO2"      "LPIN1"     "LSM10"     "LSM11"     "MAF"      
##  [397] "MAGED1"    "MAGOH"     "MAGOHB"    "MAML1"     "MAML2"     "MAMLD1"   
##  [403] "MAP2K6"    "MAPK11"    "MAPK14"    "MAPK3"     "MAPKAP1"   "MAPKAPK5" 
##  [409] "MBD3"      "MBIP"      "MCRS1"     "MDC1"      "MDM4"      "MEAF6"    
##  [415] "MECP2"     "MED1"      "MED10"     "MED12"     "MED13"     "MED14"    
##  [421] "MED15"     "MED16"     "MED17"     "MED20"     "MED23"     "MED24"    
##  [427] "MED25"     "MED27"     "MED30"     "MED31"     "MED4"      "MED6"     
##  [433] "MED7"      "MED8"      "MEF2C"     "MEN1"      "MGA"       "MLH1"     
##  [439] "MLLT1"     "MLLT3"     "MLST8"     "MNAT1"     "MOBP"      "MORC2"    
##  [445] "MOV10"     "MPHOSPH8"  "MRE11"     "MSH2"      "MT-CO1"    "MT-CO3"   
##  [451] "MTA1"      "MTA2"      "MTA3"      "MTERF1"    "MTF2"      "MTOR"     
##  [457] "MYB"       "MYBBP1A"   "MYBL1"     "MYBL2"     "MYC"       "MYL9"     
##  [463] "MYO1C"     "NABP1"     "NABP2"     "NAMPT"     "NBN"       "NCBP1"    
##  [469] "NCBP2"     "NCOA1"     "NCOA2"     "NCOA3"     "NCOA4"     "NCOA6"    
##  [475] "NCOR1"     "NCOR2"     "NDC1"      "NDRG1"     "NDUFA4"    "NELFA"    
##  [481] "NELFB"     "NELFCD"    "NELFE"     "NFATC2"    "NFE2"      "NFIB"     
##  [487] "NFIC"      "NFIX"      "NFKB1"     "NFYA"      "NFYB"      "NLRC4"    
##  [493] "NOC2L"     "NOP2"      "NOTCH1"    "NOTCH2"    "NOTCH3"    "NOTCH4"   
##  [499] "NPM1"      "NPPA"      "NR1D1"     "NR1D2"     "NR1H2"     "NR1H3"    
##  [505] "NR1I2"     "NR1I3"     "NR2C1"     "NR2C2"     "NR2C2AP"   "NR2F6"    
##  [511] "NR3C1"     "NR3C2"     "NR4A1"     "NR4A2"     "NR4A3"     "NR6A1"    
##  [517] "NRBF2"     "NRBP1"     "NUAK1"     "NUDT21"    "NUP107"    "NUP133"   
##  [523] "NUP153"    "NUP155"    "NUP160"    "NUP188"    "NUP205"    "NUP210"   
##  [529] "NUP214"    "NUP35"     "NUP37"     "NUP42"     "NUP43"     "NUP50"    
##  [535] "NUP54"     "NUP62"     "NUP85"     "NUP88"     "NUP93"     "NUP98"    
##  [541] "OCLN"      "OGT"       "PABPN1"    "PAF1"      "PAGR1"     "PAPOLA"   
##  [547] "PARP1"     "PAX5"      "PAXIP1"    "PBRM1"     "PCBP4"     "PCF11"    
##  [553] "PCGF2"     "PCGF5"     "PCGF6"     "PCNA"      "PERP"      "PEX11A"   
##  [559] "PHAX"      "PHC1"      "PHC3"      "PHF1"      "PHF19"     "PHF20"    
##  [565] "PHF20L1"   "PHLDA1"    "PIDD1"     "PIN1"      "PINK1"     "PIP4K2B"  
##  [571] "PIP4K2C"   "PIWIL2"    "PIWIL4"    "PLAGL1"    "PLD6"      "PLIN1"    
##  [577] "PLIN4"     "PLK2"      "PLXNA4"    "PMAIP1"    "PML"       "PMS2"     
##  [583] "PNPLA2"    "POLDIP3"   "POLR1A"    "POLR1B"    "POLR1C"    "POLR1D"   
##  [589] "POLR1E"    "POLR1F"    "POLR1H"    "POLR2A"    "POLR2B"    "POLR2C"   
##  [595] "POLR2D"    "POLR2E"    "POLR2F"    "POLR2G"    "POLR2H"    "POLR2I"   
##  [601] "POLR2J"    "POLR2K"    "POLR2L"    "POLR3A"    "POLR3B"    "POLR3C"   
##  [607] "POLR3D"    "POLR3E"    "POLR3F"    "POLR3G"    "POLR3H"    "POLR3K"   
##  [613] "POLRMT"    "POM121"    "POM121C"   "POMC"      "POU2F1"    "POU2F2"   
##  [619] "POU4F1"    "PPARA"     "PPARD"     "PPARGC1B"  "PPHLN1"    "PPM1A"    
##  [625] "PPM1D"     "PPP1R13B"  "PPP1R13L"  "PPP2CA"    "PPP2R1A"   "PPP2R1B"  
##  [631] "PPP2R5C"   "PRDM7"     "PRDX1"     "PRDX2"     "PRELID1"   "PRELID3A" 
##  [637] "PRKAA1"    "PRKAB1"    "PRKAB2"    "PRKACA"    "PRKAG1"    "PRKAG2"   
##  [643] "PRKCB"     "PRKCQ"     "PRKRA"     "PRMT1"     "PRMT5"     "PRMT6"    
##  [649] "PRR5"      "PSIP1"     "PSMA1"     "PSMA2"     "PSMA3"     "PSMA4"    
##  [655] "PSMA5"     "PSMA7"     "PSMB1"     "PSMB2"     "PSMB3"     "PSMB4"    
##  [661] "PSMB5"     "PSMB6"     "PSMB7"     "PSMC1"     "PSMC2"     "PSMC3"    
##  [667] "PSMC4"     "PSMC5"     "PSMC6"     "PSMD1"     "PSMD11"    "PSMD12"   
##  [673] "PSMD13"    "PSMD14"    "PSMD2"     "PSMD3"     "PSMD6"     "PSMD7"    
##  [679] "PSMD8"     "PTPN11"    "PTPN4"     "RABGGTA"   "RABGGTB"   "RAD1"     
##  [685] "RAD17"     "RAD50"     "RAD51"     "RAD51D"    "RAD9A"     "RAD9B"    
##  [691] "RAE1"      "RANBP2"    "RARA"      "RARG"      "RB1"       "RBBP4"    
##  [697] "RBBP5"     "RBBP7"     "RBBP8"     "RBFOX1"    "RBFOX3"    "RBL1"     
##  [703] "RBL2"      "RBM14"     "RBM7"      "RBM8A"     "RELA"      "REST"     
##  [709] "RET"       "RETN"      "RFC2"      "RFC3"      "RFC4"      "RFC5"     
##  [715] "RFFL"      "RGCC"      "RHEB"      "RHNO1"     "RICTOR"    "RING1"    
##  [721] "RMI1"      "RNF111"    "RNF2"      "RNF34"     "RNGTT"     "RNMT"     
##  [727] "RORA"      "RORB"      "RORC"      "RPA1"      "RPA2"      "RPA3"     
##  [733] "RPAP2"     "RPRD1A"    "RPRD1B"    "RPRD2"     "RPS27A"    "RPTOR"    
##  [739] "RRAGA"     "RRAGB"     "RRAGC"     "RRAGD"     "RRM2"      "RRM2B"    
##  [745] "RRN3"      "RRP8"      "RTF1"      "RUNX1"     "RUNX3"     "RXRA"     
##  [751] "RXRB"      "SAP130"    "SAP18"     "SAP30BP"   "SAP30L"    "SARNP"    
##  [757] "SATB2"     "SCD"       "SCD5"      "SCMH1"     "SCO2"      "SEC13"    
##  [763] "SEH1L"     "SEM1"      "SESN2"     "SESN3"     "SETD1A"    "SETD1B"   
##  [769] "SETD9"     "SETDB1"    "SF3B1"     "SFN"       "SGF29"     "SGK1"     
##  [775] "SIN3A"     "SIN3B"     "SIRT1"     "SIRT3"     "SKI"       "SKIL"     
##  [781] "SKP1"      "SKP2"      "SLBP"      "SLC2A3"    "SLC38A9"   "SLU7"     
##  [787] "SMAD2"     "SMAD3"     "SMAD4"     "SMAD6"     "SMAD7"     "SMARCA2"  
##  [793] "SMARCA4"   "SMARCA5"   "SMARCB1"   "SMARCC1"   "SMARCC2"   "SMARCD1"  
##  [799] "SMARCD2"   "SMARCD3"   "SMARCE1"   "SMURF1"    "SMURF2"    "SMYD2"    
##  [805] "SNAPC1"    "SNAPC2"    "SNAPC3"    "SNAPC4"    "SNAPC5"    "SNRPB"    
##  [811] "SNRPD3"    "SNRPE"     "SNRPF"     "SNRPG"     "SNW1"      "SOCS3"    
##  [817] "SOCS4"     "SOD2"      "SP1"       "SPI1"      "SPP1"      "SRC"      
##  [823] "SREBF1"    "SRF"       "SRRM1"     "SRRT"      "SRSF1"     "SRSF11"   
##  [829] "SRSF2"     "SRSF3"     "SRSF4"     "SRSF5"     "SRSF6"     "SRSF7"    
##  [835] "SRSF9"     "SS18"      "SS18L1"    "SSB"       "SSRP1"     "SSU72"    
##  [841] "STAT1"     "STK11"     "STUB1"     "SUDS3"     "SUMO1"     "SUMO2"    
##  [847] "SUPT16H"   "SUPT4H1"   "SUPT5H"    "SUPT6H"    "SUV39H1"   "SUZ12"    
##  [853] "SYMPK"     "TADA2A"    "TADA3"     "TAF1"      "TAF10"     "TAF11"    
##  [859] "TAF12"     "TAF13"     "TAF15"     "TAF1A"     "TAF1B"     "TAF1C"    
##  [865] "TAF1D"     "TAF2"      "TAF3"      "TAF4"      "TAF4B"     "TAF5"     
##  [871] "TAF6"      "TAF7"      "TAF9"      "TAF9B"     "TARBP2"    "TASP1"    
##  [877] "TBL1X"     "TBL1XR1"   "TBP"       "TCEA1"     "TCF12"     "TCF3"     
##  [883] "TCF7"      "TCF7L1"    "TCF7L2"    "TDG"       "TDRD12"    "TDRD6"    
##  [889] "TDRD9"     "TDRKH"     "TEAD2"     "TET1"      "TET2"      "TFAM"     
##  [895] "TFAP2E"    "TFB2M"     "TFDP1"     "TFDP2"     "TGFA"      "TGFB1"    
##  [901] "TGIF1"     "TGIF2"     "THOC1"     "THOC2"     "THOC3"     "THOC5"    
##  [907] "THOC6"     "THOC7"     "THRA"      "TIGAR"     "TJP1"      "TMEM219"  
##  [913] "TNFRSF10A" "TNFRSF10B" "TNFRSF10C" "TNFRSF10D" "TNFRSF18"  "TNKS1BP1" 
##  [919] "TNRC6A"    "TNRC6B"    "TNRC6C"    "TOP3A"     "TOPBP1"    "TP53"     
##  [925] "TP53I3"    "TP53RK"    "TP63"      "TP73"      "TPR"       "TPX2"     
##  [931] "TRIAP1"    "TRIM28"    "TRIM33"    "TRPC3"     "TSC1"      "TSC2"     
##  [937] "TSN"       "TSNAX"     "TTC5"      "TTF1"      "TXNRD1"    "U2AF1"    
##  [943] "U2AF1L4"   "U2AF2"     "UBA52"     "UBB"       "UBE2D1"    "UBE2D3"   
##  [949] "UBE2E1"    "UBE2I"     "UBE2S"     "UBTF"      "UHRF1"     "UPF3B"    
##  [955] "USP7"      "USP9X"     "UXT"       "VDR"       "VEGFA"     "VENTX"    
##  [961] "WDR33"     "WDR82"     "WRN"       "WWOX"      "WWP1"      "WWTR1"    
##  [967] "XPO1"      "XPO5"      "YAF2"      "YBX1"      "YEATS2"    "YEATS4"   
##  [973] "YES1"      "YWHAB"     "YWHAE"     "YWHAH"     "YY1"       "ZC3H11A"  
##  [979] "ZC3H8"     "ZCCHC8"    "ZFHX3"     "ZFP1"      "ZFP14"     "ZFP2"     
##  [985] "ZFP28"     "ZFP30"     "ZFP37"     "ZFP69"     "ZFP69B"    "ZFP90"    
##  [991] "ZIK1"      "ZKSCAN1"   "ZKSCAN3"   "ZKSCAN4"   "ZKSCAN5"   "ZKSCAN7"  
##  [997] "ZKSCAN8"   "ZNF10"     "ZNF100"    "ZNF101"    "ZNF112"    "ZNF12"    
## [1003] "ZNF124"    "ZNF133"    "ZNF135"    "ZNF136"    "ZNF138"    "ZNF14"    
## [1009] "ZNF140"    "ZNF141"    "ZNF143"    "ZNF154"    "ZNF155"    "ZNF157"   
## [1015] "ZNF160"    "ZNF169"    "ZNF17"     "ZNF175"    "ZNF18"     "ZNF180"   
## [1021] "ZNF184"    "ZNF189"    "ZNF19"     "ZNF195"    "ZNF197"    "ZNF2"     
## [1027] "ZNF20"     "ZNF200"    "ZNF202"    "ZNF205"    "ZNF208"    "ZNF211"   
## [1033] "ZNF212"    "ZNF213"    "ZNF221"    "ZNF222"    "ZNF223"    "ZNF224"   
## [1039] "ZNF225"    "ZNF226"    "ZNF227"    "ZNF23"     "ZNF230"    "ZNF233"   
## [1045] "ZNF234"    "ZNF235"    "ZNF248"    "ZNF25"     "ZNF250"    "ZNF253"   
## [1051] "ZNF254"    "ZNF256"    "ZNF257"    "ZNF26"     "ZNF263"    "ZNF264"   
## [1057] "ZNF266"    "ZNF267"    "ZNF268"    "ZNF273"    "ZNF274"    "ZNF28"    
## [1063] "ZNF282"    "ZNF285"    "ZNF286A"   "ZNF287"    "ZNF3"      "ZNF30"    
## [1069] "ZNF300"    "ZNF302"    "ZNF304"    "ZNF311"    "ZNF317"    "ZNF320"   
## [1075] "ZNF324"    "ZNF324B"   "ZNF331"    "ZNF333"    "ZNF334"    "ZNF337"   
## [1081] "ZNF33A"    "ZNF33B"    "ZNF34"     "ZNF347"    "ZNF350"    "ZNF354A"  
## [1087] "ZNF354B"   "ZNF354C"   "ZNF37A"    "ZNF382"    "ZNF383"    "ZNF385A"  
## [1093] "ZNF394"    "ZNF398"    "ZNF41"     "ZNF415"    "ZNF416"    "ZNF417"   
## [1099] "ZNF418"    "ZNF419"    "ZNF420"    "ZNF425"    "ZNF426"    "ZNF429"   
## [1105] "ZNF43"     "ZNF430"    "ZNF431"    "ZNF432"    "ZNF433"    "ZNF436"   
## [1111] "ZNF439"    "ZNF440"    "ZNF441"    "ZNF442"    "ZNF443"    "ZNF445"   
## [1117] "ZNF446"    "ZNF45"     "ZNF460"    "ZNF461"    "ZNF468"    "ZNF470"   
## [1123] "ZNF473"    "ZNF479"    "ZNF480"    "ZNF483"    "ZNF484"    "ZNF485"   
## [1129] "ZNF486"    "ZNF490"    "ZNF492"    "ZNF493"    "ZNF496"    "ZNF500"   
## [1135] "ZNF506"    "ZNF510"    "ZNF514"    "ZNF517"    "ZNF519"    "ZNF521"   
## [1141] "ZNF528"    "ZNF529"    "ZNF530"    "ZNF534"    "ZNF540"    "ZNF543"   
## [1147] "ZNF544"    "ZNF546"    "ZNF547"    "ZNF548"    "ZNF549"    "ZNF550"   
## [1153] "ZNF551"    "ZNF552"    "ZNF554"    "ZNF555"    "ZNF556"    "ZNF557"   
## [1159] "ZNF558"    "ZNF559"    "ZNF561"    "ZNF563"    "ZNF564"    "ZNF565"   
## [1165] "ZNF566"    "ZNF567"    "ZNF568"    "ZNF569"    "ZNF570"    "ZNF571"   
## [1171] "ZNF573"    "ZNF577"    "ZNF582"    "ZNF583"    "ZNF584"    "ZNF585A"  
## [1177] "ZNF585B"   "ZNF586"    "ZNF587"    "ZNF589"    "ZNF595"    "ZNF596"   
## [1183] "ZNF597"    "ZNF599"    "ZNF600"    "ZNF605"    "ZNF606"    "ZNF607"   
## [1189] "ZNF610"    "ZNF611"    "ZNF613"    "ZNF614"    "ZNF615"    "ZNF616"   
## [1195] "ZNF619"    "ZNF620"    "ZNF621"    "ZNF624"    "ZNF625"    "ZNF626"   
## [1201] "ZNF627"    "ZNF641"    "ZNF649"    "ZNF655"    "ZNF658"    "ZNF658B"  
## [1207] "ZNF660"    "ZNF662"    "ZNF664"    "ZNF665"    "ZNF667"    "ZNF668"   
## [1213] "ZNF669"    "ZNF670"    "ZNF671"    "ZNF675"    "ZNF676"    "ZNF677"   
## [1219] "ZNF678"    "ZNF680"    "ZNF681"    "ZNF682"    "ZNF684"    "ZNF688"   
## [1225] "ZNF689"    "ZNF691"    "ZNF692"    "ZNF696"    "ZNF697"    "ZNF699"   
## [1231] "ZNF70"     "ZNF700"    "ZNF701"    "ZNF702P"   "ZNF703"    "ZNF704"   
## [1237] "ZNF707"    "ZNF708"    "ZNF709"    "ZNF71"     "ZNF710"    "ZNF711"   
## [1243] "ZNF713"    "ZNF714"    "ZNF716"    "ZNF717"    "ZNF718"    "ZNF721"   
## [1249] "ZNF724"    "ZNF726"    "ZNF726P1"  "ZNF727"    "ZNF736"    "ZNF737"   
## [1255] "ZNF738"    "ZNF74"     "ZNF740"    "ZNF746"    "ZNF747"    "ZNF749"   
## [1261] "ZNF75A"    "ZNF75D"    "ZNF761"    "ZNF764"    "ZNF765"    "ZNF767P"  
## [1267] "ZNF77"     "ZNF770"    "ZNF771"    "ZNF772"    "ZNF773"    "ZNF774"   
## [1273] "ZNF775"    "ZNF776"    "ZNF777"    "ZNF778"    "ZNF782"    "ZNF785"   
## [1279] "ZNF786"    "ZNF79"     "ZNF790"    "ZNF791"    "ZNF792"    "ZNF793"   
## [1285] "ZNF799"    "ZNF816"    "ZNF839"    "ZNF860"    "ZNF92"     "ZNF93"    
## [1291] "ZNF99"     "ZSCAN25"   "ZSCAN32"   "ZZZ3"     
## 
## [[1]]$`DOWN genesets.Generation of second messenger molecules`
##  [1] "CD101"     "CD247"     "CD3D"      "CD3E"      "CD4"       "EVL"      
##  [7] "GRAP2"     "HLA-DPA1"  "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1" 
## [13] "HLA-DQB2"  "HLA-DRA"   "HLA-DRB1"  "HLA-DRB5"  "LAT"       "LCK"      
## [19] "LCP2"      "NCK1"      "PAK1"      "PAK2"      "PAK3"      "PLCG1"    
## [25] "PLCG2"     "TRAC"      "TRAV19"    "TRAV29DV5" "TRAV8-4"   "TRBC1"    
## [31] "TRBV12-3"  "TRBV7-9"   "VASP"      "WAS"       "ZAP70"    
## 
## [[1]]$`DOWN genesets.Generic Transcription Pathway`
##   [1] "ABCA6"     "ABL1"      "ACTL6A"    "ADRM1"     "AGO1"      "AGO2"     
##   [7] "AGO3"      "AGO4"      "AGRP"      "AIFM2"     "AKT1"      "AKT2"     
##  [13] "AKT3"      "ANAPC1"    "ANAPC10"   "ANAPC11"   "ANAPC15"   "ANAPC2"   
##  [19] "ANAPC4"    "ANAPC5"    "ANAPC7"    "APAF1"     "APOE"      "AR"       
##  [25] "ARID1A"    "ARID1B"    "ARID2"     "ARID3A"    "ARNT"      "ARNTL"    
##  [31] "ASH2L"     "ATAD2"     "ATF2"      "ATM"       "ATR"       "ATRIP"    
##  [37] "ATXN3"     "AURKA"     "AURKB"     "AUTS2"     "AXIN1"     "BANP"     
##  [43] "BARD1"     "BAX"       "BBC3"      "BCL2L14"   "BCL6"      "BGLAP"    
##  [49] "BID"       "BIRC5"     "BMI1"      "BNIP3L"    "BRCA1"     "BRD1"     
##  [55] "BRD2"      "BRD7"      "BRIP1"     "BRPF1"     "BRPF3"     "BTG2"     
##  [61] "CALM1"     "CAMK2A"    "CAMK2D"    "CAMK2G"    "CAMK4"     "CARM1"    
##  [67] "CASP1"     "CASP10"    "CASP2"     "CAT"       "CAV1"      "CBFB"     
##  [73] "CBX2"      "CBX4"      "CBX5"      "CBX6"      "CBX8"      "CCNA2"    
##  [79] "CCNB1"     "CCNC"      "CCND1"     "CCND2"     "CCNE1"     "CCNE2"    
##  [85] "CCNG1"     "CCNG2"     "CCNK"      "CCNT1"     "CCNT2"     "CDC16"    
##  [91] "CDC23"     "CDC25C"    "CDC26"     "CDC27"     "CDC7"      "CDK1"     
##  [97] "CDK12"     "CDK13"     "CDK2"      "CDK4"      "CDK5"      "CDK6"     
## [103] "CDK7"      "CDK8"      "CDK9"      "CDKN1B"    "CDKN2A"    "CEBPB"    
## [109] "CENPJ"     "CHD3"      "CHD4"      "CHEK1"     "CHEK2"     "CHM"      
## [115] "CITED2"    "CITED4"    "CNOT1"     "CNOT10"    "CNOT11"    "CNOT2"    
## [121] "CNOT3"     "CNOT4"     "CNOT6"     "CNOT6L"    "CNOT7"     "CNOT8"    
## [127] "COL1A2"    "COX4I1"    "COX5A"     "COX5B"     "COX6A1"    "COX6B1"   
## [133] "COX6B2"    "COX6C"     "COX7A1"    "COX7A2"    "COX7A2L"   "COX7B"    
## [139] "COX7C"     "COX8A"     "CR1"       "CRADD"     "CREB1"     "CREBBP"   
## [145] "CSF1R"     "CSNK2A1"   "CSNK2A2"   "CSNK2B"    "CTDP1"     "CTNNB1"   
## [151] "CTSK"      "CTSL"      "CTSV"      "CUL1"      "CYCS"      "DAXX"     
## [157] "DDB2"      "DDIT3"     "DEK"       "DGCR8"     "DLL1"      "DLX6"     
## [163] "DNA2"      "DPY30"     "DYRK2"     "E2F1"      "E2F4"      "E2F5"     
## [169] "E2F6"      "E2F7"      "E2F8"      "EED"       "EHMT1"     "EHMT2"    
## [175] "ELF2"      "ELL"       "ELOB"      "ELOC"      "EP300"     "EPC1"     
## [181] "ERBB2"     "ERCC2"     "ERCC3"     "ESR1"      "ESR2"      "ESRRA"    
## [187] "EXO1"      "EZH2"      "FANCC"     "FANCD2"    "FANCI"     "FAS"      
## [193] "FASLG"     "FOS"       "FOXO1"     "FOXO4"     "FZR1"      "G6PC1"    
## [199] "GAMT"      "GATA2"     "GATA3"     "GATAD2A"   "GATAD2B"   "GCK"      
## [205] "GLI3"      "GLS"       "GLS2"      "GP1BA"     "GPAM"      "GPI"      
## [211] "GPRIN1"    "GPS2"      "GPX2"      "GRIN2A"    "GSK3B"     "GTF2F1"   
## [217] "GTF2F2"    "GTF2H1"    "GTF2H2"    "GTF2H3"    "GTF2H4"    "GTF2H5"   
## [223] "H19"       "H2AC20"    "H2AJ"      "H2AZ2"     "H3-3A"     "H3C15"    
## [229] "HDAC1"     "HDAC10"    "HDAC11"    "HDAC2"     "HDAC3"     "HDAC5"    
## [235] "HDAC6"     "HDAC7"     "HDAC8"     "HDAC9"     "HES1"      "HEY1"     
## [241] "HEY2"      "HIPK1"     "HIVEP3"    "HNF4A"     "HSPD1"     "HTT"      
## [247] "HUS1"      "IFNG"      "IGFBP3"    "IL6"       "ING2"      "ING5"     
## [253] "IQSEC3"    "IRAK1"     "ITCH"      "ITGA4"     "ITGA5"     "ITGAL"    
## [259] "JMY"       "JUN"       "JUNB"      "KAT2A"     "KAT2B"     "KAT5"     
## [265] "KAT6A"     "KCTD1"     "KCTD15"    "KCTD6"     "KDM5B"     "KLF4"     
## [271] "KMT2A"     "KMT2B"     "KMT2C"     "KMT2D"     "KMT5A"     "KRAS"     
## [277] "KRBA1"     "KRBOX4"    "L3MBTL1"   "L3MBTL2"   "LAMTOR1"   "LAMTOR2"  
## [283] "LAMTOR3"   "LAMTOR4"   "LAMTOR5"   "LBR"       "LDB1"      "LEF1"     
## [289] "LGALS3"    "LMO2"      "MAF"       "MAGED1"    "MAML1"     "MAML2"    
## [295] "MAMLD1"    "MAP2K6"    "MAPK11"    "MAPK14"    "MAPK3"     "MAPKAP1"  
## [301] "MAPKAPK5"  "MBD3"      "MDC1"      "MDM4"      "MEAF6"     "MECP2"    
## [307] "MED1"      "MED10"     "MED12"     "MED13"     "MED14"     "MED15"    
## [313] "MED16"     "MED17"     "MED20"     "MED23"     "MED24"     "MED25"    
## [319] "MED27"     "MED30"     "MED31"     "MED4"      "MED6"      "MED7"     
## [325] "MED8"      "MEF2C"     "MEN1"      "MGA"       "MLH1"      "MLST8"    
## [331] "MNAT1"     "MOBP"      "MOV10"     "MRE11"     "MSH2"      "MT-CO1"   
## [337] "MT-CO3"    "MTA2"      "MTOR"      "MYB"       "MYBL2"     "MYC"      
## [343] "MYL9"      "NAMPT"     "NBN"       "NCOR1"     "NCOR2"     "NDRG1"    
## [349] "NDUFA4"    "NELFA"     "NELFB"     "NELFCD"    "NELFE"     "NFATC2"   
## [355] "NFE2"      "NFKB1"     "NFYA"      "NFYB"      "NLRC4"     "NOC2L"    
## [361] "NOP2"      "NOTCH1"    "NOTCH2"    "NOTCH3"    "NOTCH4"    "NPM1"     
## [367] "NPPA"      "NR1D1"     "NR1D2"     "NR1H2"     "NR1H3"     "NR1I2"    
## [373] "NR1I3"     "NR2C1"     "NR2C2"     "NR2C2AP"   "NR2F6"     "NR3C1"    
## [379] "NR3C2"     "NR4A1"     "NR4A2"     "NR4A3"     "NR6A1"     "NRBF2"    
## [385] "NRBP1"     "NUAK1"     "OCLN"      "PARP1"     "PAX5"      "PBRM1"    
## [391] "PCBP4"     "PCGF2"     "PCGF5"     "PCGF6"     "PCNA"      "PERP"     
## [397] "PHC1"      "PHC3"      "PHF20"     "PIDD1"     "PIN1"      "PINK1"    
## [403] "PIP4K2B"   "PIP4K2C"   "PLAGL1"    "PLK2"      "PLXNA4"    "PMAIP1"   
## [409] "PML"       "PMS2"      "POLR2A"    "POLR2B"    "POLR2C"    "POLR2D"   
## [415] "POLR2E"    "POLR2F"    "POLR2G"    "POLR2H"    "POLR2I"    "POLR2J"   
## [421] "POLR2K"    "POLR2L"    "POMC"      "POU4F1"    "PPARA"     "PPARD"    
## [427] "PPARGC1B"  "PPM1A"     "PPM1D"     "PPP1R13B"  "PPP1R13L"  "PPP2CA"   
## [433] "PPP2R1A"   "PPP2R1B"   "PPP2R5C"   "PRDM7"     "PRDX1"     "PRDX2"    
## [439] "PRELID1"   "PRELID3A"  "PRKAA1"    "PRKAB1"    "PRKAB2"    "PRKACA"   
## [445] "PRKAG1"    "PRKAG2"    "PRKCB"     "PRKCQ"     "PRMT1"     "PRMT5"    
## [451] "PRMT6"     "PRR5"      "PSMA1"     "PSMA2"     "PSMA3"     "PSMA4"    
## [457] "PSMA5"     "PSMA7"     "PSMB1"     "PSMB2"     "PSMB3"     "PSMB4"    
## [463] "PSMB5"     "PSMB6"     "PSMB7"     "PSMC1"     "PSMC2"     "PSMC3"    
## [469] "PSMC4"     "PSMC5"     "PSMC6"     "PSMD1"     "PSMD11"    "PSMD12"   
## [475] "PSMD13"    "PSMD14"    "PSMD2"     "PSMD3"     "PSMD6"     "PSMD7"    
## [481] "PSMD8"     "PTPN11"    "PTPN4"     "RABGGTA"   "RABGGTB"   "RAD1"     
## [487] "RAD17"     "RAD50"     "RAD51"     "RAD51D"    "RAD9A"     "RAD9B"    
## [493] "RARA"      "RARG"      "RB1"       "RBBP4"     "RBBP5"     "RBBP7"    
## [499] "RBBP8"     "RBFOX1"    "RBFOX3"    "RBL1"      "RBL2"      "RBM14"    
## [505] "RELA"      "REST"      "RET"       "RETN"      "RFC2"      "RFC3"     
## [511] "RFC4"      "RFC5"      "RFFL"      "RGCC"      "RHEB"      "RHNO1"    
## [517] "RICTOR"    "RING1"     "RMI1"      "RNF111"    "RNF2"      "RNF34"    
## [523] "RORA"      "RORB"      "RORC"      "RPA1"      "RPA2"      "RPA3"     
## [529] "RPS27A"    "RPTOR"     "RRAGA"     "RRAGB"     "RRAGC"     "RRAGD"    
## [535] "RRM2"      "RRM2B"     "RUNX1"     "RUNX3"     "RXRA"      "RXRB"     
## [541] "SATB2"     "SCMH1"     "SCO2"      "SEM1"      "SESN2"     "SESN3"    
## [547] "SETD1A"    "SETD1B"    "SETD9"     "SFN"       "SGK1"      "SIN3A"    
## [553] "SIN3B"     "SIRT1"     "SIRT3"     "SKI"       "SKIL"      "SKP1"     
## [559] "SKP2"      "SLC2A3"    "SLC38A9"   "SMAD2"     "SMAD3"     "SMAD4"    
## [565] "SMAD6"     "SMAD7"     "SMARCA2"   "SMARCA4"   "SMARCB1"   "SMARCC1"  
## [571] "SMARCC2"   "SMARCD1"   "SMARCD2"   "SMARCD3"   "SMARCE1"   "SMURF1"   
## [577] "SMURF2"    "SMYD2"     "SNW1"      "SOCS3"     "SOCS4"     "SOD2"     
## [583] "SP1"       "SPI1"      "SPP1"      "SRC"       "SREBF1"    "SRF"      
## [589] "SSRP1"     "STAT1"     "STK11"     "STUB1"     "SUMO1"     "SUPT16H"  
## [595] "SUPT4H1"   "SUPT5H"    "SUZ12"     "TAF1"      "TAF10"     "TAF11"    
## [601] "TAF12"     "TAF13"     "TAF15"     "TAF2"      "TAF3"      "TAF4"     
## [607] "TAF4B"     "TAF5"      "TAF6"      "TAF7"      "TAF9"      "TAF9B"    
## [613] "TBL1X"     "TBL1XR1"   "TBP"       "TCEA1"     "TCF12"     "TCF3"     
## [619] "TCF7"      "TCF7L1"    "TCF7L2"    "TEAD2"     "TFAP2E"    "TFDP1"    
## [625] "TFDP2"     "TGFA"      "TGFB1"     "TGIF1"     "TGIF2"     "THRA"     
## [631] "TIGAR"     "TJP1"      "TMEM219"   "TNFRSF10A" "TNFRSF10B" "TNFRSF10C"
## [637] "TNFRSF10D" "TNFRSF18"  "TNKS1BP1"  "TNRC6A"    "TNRC6B"    "TNRC6C"   
## [643] "TOP3A"     "TOPBP1"    "TP53"      "TP53I3"    "TP53RK"    "TP63"     
## [649] "TP73"      "TPX2"      "TRIAP1"    "TRIM28"    "TRIM33"    "TRPC3"    
## [655] "TSC1"      "TSC2"      "TTC5"      "TXNRD1"    "UBA52"     "UBB"      
## [661] "UBE2D1"    "UBE2D3"    "UBE2E1"    "UBE2I"     "UBE2S"     "USP7"     
## [667] "USP9X"     "UXT"       "VDR"       "VEGFA"     "VENTX"     "WRN"      
## [673] "WWOX"      "WWP1"      "WWTR1"     "XPO1"      "YAF2"      "YBX1"     
## [679] "YEATS4"    "YES1"      "YWHAB"     "YWHAE"     "YWHAH"     "YY1"      
## [685] "ZFHX3"     "ZFP1"      "ZFP14"     "ZFP2"      "ZFP28"     "ZFP30"    
## [691] "ZFP37"     "ZFP69"     "ZFP69B"    "ZFP90"     "ZIK1"      "ZKSCAN1"  
## [697] "ZKSCAN3"   "ZKSCAN4"   "ZKSCAN5"   "ZKSCAN7"   "ZKSCAN8"   "ZNF10"    
## [703] "ZNF100"    "ZNF101"    "ZNF112"    "ZNF12"     "ZNF124"    "ZNF133"   
## [709] "ZNF135"    "ZNF136"    "ZNF138"    "ZNF14"     "ZNF140"    "ZNF141"   
## [715] "ZNF154"    "ZNF155"    "ZNF157"    "ZNF160"    "ZNF169"    "ZNF17"    
## [721] "ZNF175"    "ZNF18"     "ZNF180"    "ZNF184"    "ZNF189"    "ZNF19"    
## [727] "ZNF195"    "ZNF197"    "ZNF2"      "ZNF20"     "ZNF200"    "ZNF202"   
## [733] "ZNF205"    "ZNF208"    "ZNF211"    "ZNF212"    "ZNF213"    "ZNF221"   
## [739] "ZNF222"    "ZNF223"    "ZNF224"    "ZNF225"    "ZNF226"    "ZNF227"   
## [745] "ZNF23"     "ZNF230"    "ZNF233"    "ZNF234"    "ZNF235"    "ZNF248"   
## [751] "ZNF25"     "ZNF250"    "ZNF253"    "ZNF254"    "ZNF256"    "ZNF257"   
## [757] "ZNF26"     "ZNF263"    "ZNF264"    "ZNF266"    "ZNF267"    "ZNF268"   
## [763] "ZNF273"    "ZNF274"    "ZNF28"     "ZNF282"    "ZNF285"    "ZNF286A"  
## [769] "ZNF287"    "ZNF3"      "ZNF30"     "ZNF300"    "ZNF302"    "ZNF304"   
## [775] "ZNF311"    "ZNF317"    "ZNF320"    "ZNF324"    "ZNF324B"   "ZNF331"   
## [781] "ZNF333"    "ZNF334"    "ZNF337"    "ZNF33A"    "ZNF33B"    "ZNF34"    
## [787] "ZNF347"    "ZNF350"    "ZNF354A"   "ZNF354B"   "ZNF354C"   "ZNF37A"   
## [793] "ZNF382"    "ZNF383"    "ZNF385A"   "ZNF394"    "ZNF398"    "ZNF41"    
## [799] "ZNF415"    "ZNF416"    "ZNF417"    "ZNF418"    "ZNF419"    "ZNF420"   
## [805] "ZNF425"    "ZNF426"    "ZNF429"    "ZNF43"     "ZNF430"    "ZNF431"   
## [811] "ZNF432"    "ZNF433"    "ZNF436"    "ZNF439"    "ZNF440"    "ZNF441"   
## [817] "ZNF442"    "ZNF443"    "ZNF445"    "ZNF446"    "ZNF45"     "ZNF460"   
## [823] "ZNF461"    "ZNF468"    "ZNF470"    "ZNF473"    "ZNF479"    "ZNF480"   
## [829] "ZNF483"    "ZNF484"    "ZNF485"    "ZNF486"    "ZNF490"    "ZNF492"   
## [835] "ZNF493"    "ZNF496"    "ZNF500"    "ZNF506"    "ZNF510"    "ZNF514"   
## [841] "ZNF517"    "ZNF519"    "ZNF521"    "ZNF528"    "ZNF529"    "ZNF530"   
## [847] "ZNF540"    "ZNF543"    "ZNF544"    "ZNF546"    "ZNF547"    "ZNF548"   
## [853] "ZNF549"    "ZNF550"    "ZNF551"    "ZNF552"    "ZNF554"    "ZNF555"   
## [859] "ZNF556"    "ZNF557"    "ZNF558"    "ZNF559"    "ZNF561"    "ZNF563"   
## [865] "ZNF564"    "ZNF565"    "ZNF566"    "ZNF567"    "ZNF568"    "ZNF569"   
## [871] "ZNF570"    "ZNF571"    "ZNF573"    "ZNF577"    "ZNF582"    "ZNF583"   
## [877] "ZNF584"    "ZNF585A"   "ZNF585B"   "ZNF586"    "ZNF587"    "ZNF589"   
## [883] "ZNF595"    "ZNF596"    "ZNF597"    "ZNF599"    "ZNF600"    "ZNF605"   
## [889] "ZNF606"    "ZNF607"    "ZNF610"    "ZNF611"    "ZNF613"    "ZNF614"   
## [895] "ZNF615"    "ZNF616"    "ZNF619"    "ZNF620"    "ZNF621"    "ZNF624"   
## [901] "ZNF625"    "ZNF626"    "ZNF627"    "ZNF641"    "ZNF649"    "ZNF655"   
## [907] "ZNF658"    "ZNF658B"   "ZNF660"    "ZNF662"    "ZNF664"    "ZNF665"   
## [913] "ZNF667"    "ZNF668"    "ZNF669"    "ZNF670"    "ZNF671"    "ZNF675"   
## [919] "ZNF676"    "ZNF677"    "ZNF678"    "ZNF680"    "ZNF681"    "ZNF682"   
## [925] "ZNF684"    "ZNF688"    "ZNF689"    "ZNF691"    "ZNF692"    "ZNF696"   
## [931] "ZNF697"    "ZNF699"    "ZNF70"     "ZNF700"    "ZNF701"    "ZNF702P"  
## [937] "ZNF703"    "ZNF704"    "ZNF707"    "ZNF708"    "ZNF709"    "ZNF71"    
## [943] "ZNF710"    "ZNF711"    "ZNF713"    "ZNF714"    "ZNF716"    "ZNF717"   
## [949] "ZNF718"    "ZNF721"    "ZNF724"    "ZNF726"    "ZNF726P1"  "ZNF727"   
## [955] "ZNF736"    "ZNF737"    "ZNF738"    "ZNF74"     "ZNF740"    "ZNF746"   
## [961] "ZNF747"    "ZNF749"    "ZNF75A"    "ZNF75D"    "ZNF761"    "ZNF764"   
## [967] "ZNF767P"   "ZNF77"     "ZNF770"    "ZNF771"    "ZNF772"    "ZNF773"   
## [973] "ZNF774"    "ZNF775"    "ZNF776"    "ZNF777"    "ZNF778"    "ZNF782"   
## [979] "ZNF785"    "ZNF786"    "ZNF79"     "ZNF790"    "ZNF791"    "ZNF792"   
## [985] "ZNF793"    "ZNF799"    "ZNF839"    "ZNF860"    "ZNF92"     "ZNF99"    
## [991] "ZSCAN25"   "ZSCAN32"  
## 
## [[1]]$`DOWN genesets.NR1H2 and NR1H3-mediated signaling`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOD"    "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "FASN"   
## [15] "GPS2"    "HDAC3"   "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"  
## [22] "NCOA1"   "NCOR1"   "NCOR2"   "NR1H2"   "NR1H3"   "NRIP1"   "PLIN1"  
## [29] "PLTP"    "RXRA"    "RXRB"    "SCD"     "SREBF1"  "TBL1X"   "TBL1XR1"
## [36] "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOD"    "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "GPS2"   
## [15] "HDAC3"   "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"   "NCOA1"  
## [22] "NCOR1"   "NCOR2"   "NR1H2"   "NR1H3"   "PLTP"    "RXRA"    "RXRB"   
## [29] "TBL1X"   "TBL1XR1" "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.PD-1 signaling`
##  [1] "CD247"     "CD274"     "CD3D"      "CD3E"      "CD4"       "CSK"      
##  [7] "HLA-DPA1"  "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1"  "HLA-DQB2" 
## [13] "HLA-DRA"   "HLA-DRB1"  "HLA-DRB5"  "LCK"       "PDCD1LG2"  "PTPN11"   
## [19] "PTPN6"     "TRAC"      "TRAV19"    "TRAV29DV5" "TRAV8-4"   "TRBC1"    
## [25] "TRBV12-3"  "TRBV7-9"  
## 
## [[1]]$`DOWN genesets.Phosphorylation of CD3 and TCR zeta chains`
##  [1] "CD247"     "CD3D"      "CD3E"      "CD4"       "CSK"       "HLA-DPA1" 
##  [7] "HLA-DPB1"  "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1"  "HLA-DQB2"  "HLA-DRA"  
## [13] "HLA-DRB1"  "HLA-DRB5"  "LCK"       "PTPN22"    "PTPRC"     "PTPRJ"    
## [19] "TRAC"      "TRAV19"    "TRAV29DV5" "TRAV8-4"   "TRBC1"     "TRBV12-3" 
## [25] "TRBV7-9"  
## 
## [[1]]$`DOWN genesets.RNA Polymerase II Transcription`
##    [1] "ABCA6"     "ABL1"      "ACTL6A"    "ADRM1"     "AFF4"      "AGO1"     
##    [7] "AGO2"      "AGO3"      "AGO4"      "AGRP"      "AIFM2"     "AKT1"     
##   [13] "AKT2"      "AKT3"      "ALYREF"    "ANAPC1"    "ANAPC10"   "ANAPC11"  
##   [19] "ANAPC15"   "ANAPC2"    "ANAPC4"    "ANAPC5"    "ANAPC7"    "APAF1"    
##   [25] "APOE"      "AR"        "ARID1A"    "ARID1B"    "ARID2"     "ARID3A"   
##   [31] "ARNT"      "ARNTL"     "ASH2L"     "ATAD2"     "ATF2"      "ATM"      
##   [37] "ATR"       "ATRIP"     "ATXN3"     "AURKA"     "AURKB"     "AUTS2"    
##   [43] "AXIN1"     "BANP"      "BARD1"     "BAX"       "BBC3"      "BCL2L14"  
##   [49] "BCL6"      "BGLAP"     "BID"       "BIRC5"     "BMI1"      "BNIP3L"   
##   [55] "BRCA1"     "BRD1"      "BRD2"      "BRD7"      "BRIP1"     "BRPF1"    
##   [61] "BRPF3"     "BTG2"      "CALM1"     "CAMK2A"    "CAMK2D"    "CAMK2G"   
##   [67] "CAMK4"     "CARM1"     "CASC3"     "CASP1"     "CASP10"    "CASP2"    
##   [73] "CAT"       "CAV1"      "CBFB"      "CBX2"      "CBX4"      "CBX5"     
##   [79] "CBX6"      "CBX8"      "CCNA2"     "CCNB1"     "CCNC"      "CCND1"    
##   [85] "CCND2"     "CCNE1"     "CCNE2"     "CCNG1"     "CCNG2"     "CCNK"     
##   [91] "CCNT1"     "CCNT2"     "CDC16"     "CDC23"     "CDC25C"    "CDC26"    
##   [97] "CDC27"     "CDC40"     "CDC7"      "CDC73"     "CDK1"      "CDK12"    
##  [103] "CDK13"     "CDK2"      "CDK4"      "CDK5"      "CDK6"      "CDK7"     
##  [109] "CDK8"      "CDK9"      "CDKN1B"    "CDKN2A"    "CEBPB"     "CENPJ"    
##  [115] "CHD3"      "CHD4"      "CHEK1"     "CHEK2"     "CHM"       "CHTOP"    
##  [121] "CITED2"    "CITED4"    "CLP1"      "CNOT1"     "CNOT10"    "CNOT11"   
##  [127] "CNOT2"     "CNOT3"     "CNOT4"     "CNOT6"     "CNOT6L"    "CNOT7"    
##  [133] "CNOT8"     "COL1A2"    "COX4I1"    "COX5A"     "COX5B"     "COX6A1"   
##  [139] "COX6B1"    "COX6B2"    "COX6C"     "COX7A1"    "COX7A2"    "COX7A2L"  
##  [145] "COX7B"     "COX7C"     "COX8A"     "CPSF1"     "CPSF2"     "CPSF3"    
##  [151] "CPSF4"     "CPSF6"     "CPSF7"     "CR1"       "CRADD"     "CREB1"    
##  [157] "CREBBP"    "CSF1R"     "CSNK2A1"   "CSNK2A2"   "CSNK2B"    "CSTF1"    
##  [163] "CSTF2"     "CSTF2T"    "CSTF3"     "CTDP1"     "CTNNB1"    "CTR9"     
##  [169] "CTSK"      "CTSL"      "CTSV"      "CUL1"      "CYCS"      "DAXX"     
##  [175] "DDB2"      "DDIT3"     "DDX39A"    "DDX39B"    "DEK"       "DGCR8"    
##  [181] "DHX38"     "DLL1"      "DLX6"      "DNA2"      "DPY30"     "DYRK2"    
##  [187] "E2F1"      "E2F4"      "E2F5"      "E2F6"      "E2F7"      "E2F8"     
##  [193] "EAF1"      "EAF2"      "EED"       "EHMT1"     "EHMT2"     "EIF4A3"   
##  [199] "ELF2"      "ELL"       "ELL3"      "ELOB"      "ELOC"      "EP300"    
##  [205] "EPC1"      "ERBB2"     "ERCC2"     "ERCC3"     "ESR1"      "ESR2"     
##  [211] "ESRRA"     "EXO1"      "EZH2"      "FANCC"     "FANCD2"    "FANCI"    
##  [217] "FAS"       "FASLG"     "FIP1L1"    "FOS"       "FOXO1"     "FOXO4"    
##  [223] "FYTTD1"    "FZR1"      "G6PC1"     "GAMT"      "GATA2"     "GATA3"    
##  [229] "GATAD2A"   "GATAD2B"   "GCK"       "GLI3"      "GLS"       "GLS2"     
##  [235] "GP1BA"     "GPAM"      "GPI"       "GPRIN1"    "GPS2"      "GPX2"     
##  [241] "GRIN2A"    "GSK3B"     "GTF2A1"    "GTF2A2"    "GTF2B"     "GTF2E1"   
##  [247] "GTF2E2"    "GTF2F1"    "GTF2F2"    "GTF2H1"    "GTF2H2"    "GTF2H3"   
##  [253] "GTF2H4"    "GTF2H5"    "H19"       "H2AC20"    "H2AJ"      "H2AZ2"    
##  [259] "H3-3A"     "H3C15"     "HDAC1"     "HDAC10"    "HDAC11"    "HDAC2"    
##  [265] "HDAC3"     "HDAC5"     "HDAC6"     "HDAC7"     "HDAC8"     "HDAC9"    
##  [271] "HES1"      "HEY1"      "HEY2"      "HIPK1"     "HIVEP3"    "HNF4A"    
##  [277] "HSPD1"     "HTT"       "HUS1"      "ICE1"      "ICE2"      "IFNG"     
##  [283] "IGFBP3"    "IL6"       "ING2"      "ING5"      "INTS1"     "INTS12"   
##  [289] "INTS2"     "INTS3"     "INTS4"     "INTS5"     "INTS6"     "INTS7"    
##  [295] "INTS8"     "INTS9"     "IQSEC3"    "IRAK1"     "ITCH"      "ITGA4"    
##  [301] "ITGA5"     "ITGAL"     "IWS1"      "JMY"       "JUN"       "JUNB"     
##  [307] "KAT2A"     "KAT2B"     "KAT5"      "KAT6A"     "KCTD1"     "KCTD15"   
##  [313] "KCTD6"     "KDM5B"     "KLF4"      "KMT2A"     "KMT2B"     "KMT2C"    
##  [319] "KMT2D"     "KMT5A"     "KRAS"      "KRBA1"     "KRBOX4"    "L3MBTL1"  
##  [325] "L3MBTL2"   "LAMTOR1"   "LAMTOR2"   "LAMTOR3"   "LAMTOR4"   "LAMTOR5"  
##  [331] "LBR"       "LDB1"      "LEF1"      "LEO1"      "LGALS3"    "LMO2"     
##  [337] "LSM10"     "LSM11"     "MAF"       "MAGED1"    "MAGOH"     "MAGOHB"   
##  [343] "MAML1"     "MAML2"     "MAMLD1"    "MAP2K6"    "MAPK11"    "MAPK14"   
##  [349] "MAPK3"     "MAPKAP1"   "MAPKAPK5"  "MBD3"      "MDC1"      "MDM4"     
##  [355] "MEAF6"     "MECP2"     "MED1"      "MED10"     "MED12"     "MED13"    
##  [361] "MED14"     "MED15"     "MED16"     "MED17"     "MED20"     "MED23"    
##  [367] "MED24"     "MED25"     "MED27"     "MED30"     "MED31"     "MED4"     
##  [373] "MED6"      "MED7"      "MED8"      "MEF2C"     "MEN1"      "MGA"      
##  [379] "MLH1"      "MLLT1"     "MLLT3"     "MLST8"     "MNAT1"     "MOBP"     
##  [385] "MOV10"     "MRE11"     "MSH2"      "MT-CO1"    "MT-CO3"    "MTA2"     
##  [391] "MTOR"      "MYB"       "MYBL2"     "MYC"       "MYL9"      "NABP1"    
##  [397] "NABP2"     "NAMPT"     "NBN"       "NCBP1"     "NCBP2"     "NCOR1"    
##  [403] "NCOR2"     "NDRG1"     "NDUFA4"    "NELFA"     "NELFB"     "NELFCD"   
##  [409] "NELFE"     "NFATC2"    "NFE2"      "NFKB1"     "NFYA"      "NFYB"     
##  [415] "NLRC4"     "NOC2L"     "NOP2"      "NOTCH1"    "NOTCH2"    "NOTCH3"   
##  [421] "NOTCH4"    "NPM1"      "NPPA"      "NR1D1"     "NR1D2"     "NR1H2"    
##  [427] "NR1H3"     "NR1I2"     "NR1I3"     "NR2C1"     "NR2C2"     "NR2C2AP"  
##  [433] "NR2F6"     "NR3C1"     "NR3C2"     "NR4A1"     "NR4A2"     "NR4A3"    
##  [439] "NR6A1"     "NRBF2"     "NRBP1"     "NUAK1"     "NUDT21"    "OCLN"     
##  [445] "PABPN1"    "PAF1"      "PAPOLA"    "PARP1"     "PAX5"      "PBRM1"    
##  [451] "PCBP4"     "PCF11"     "PCGF2"     "PCGF5"     "PCGF6"     "PCNA"     
##  [457] "PERP"      "PHAX"      "PHC1"      "PHC3"      "PHF20"     "PIDD1"    
##  [463] "PIN1"      "PINK1"     "PIP4K2B"   "PIP4K2C"   "PLAGL1"    "PLK2"     
##  [469] "PLXNA4"    "PMAIP1"    "PML"       "PMS2"      "POLDIP3"   "POLR2A"   
##  [475] "POLR2B"    "POLR2C"    "POLR2D"    "POLR2E"    "POLR2F"    "POLR2G"   
##  [481] "POLR2H"    "POLR2I"    "POLR2J"    "POLR2K"    "POLR2L"    "POMC"     
##  [487] "POU2F1"    "POU2F2"    "POU4F1"    "PPARA"     "PPARD"     "PPARGC1B" 
##  [493] "PPM1A"     "PPM1D"     "PPP1R13B"  "PPP1R13L"  "PPP2CA"    "PPP2R1A"  
##  [499] "PPP2R1B"   "PPP2R5C"   "PRDM7"     "PRDX1"     "PRDX2"     "PRELID1"  
##  [505] "PRELID3A"  "PRKAA1"    "PRKAB1"    "PRKAB2"    "PRKACA"    "PRKAG1"   
##  [511] "PRKAG2"    "PRKCB"     "PRKCQ"     "PRMT1"     "PRMT5"     "PRMT6"    
##  [517] "PRR5"      "PSMA1"     "PSMA2"     "PSMA3"     "PSMA4"     "PSMA5"    
##  [523] "PSMA7"     "PSMB1"     "PSMB2"     "PSMB3"     "PSMB4"     "PSMB5"    
##  [529] "PSMB6"     "PSMB7"     "PSMC1"     "PSMC2"     "PSMC3"     "PSMC4"    
##  [535] "PSMC5"     "PSMC6"     "PSMD1"     "PSMD11"    "PSMD12"    "PSMD13"   
##  [541] "PSMD14"    "PSMD2"     "PSMD3"     "PSMD6"     "PSMD7"     "PSMD8"    
##  [547] "PTPN11"    "PTPN4"     "RABGGTA"   "RABGGTB"   "RAD1"      "RAD17"    
##  [553] "RAD50"     "RAD51"     "RAD51D"    "RAD9A"     "RAD9B"     "RARA"     
##  [559] "RARG"      "RB1"       "RBBP4"     "RBBP5"     "RBBP7"     "RBBP8"    
##  [565] "RBFOX1"    "RBFOX3"    "RBL1"      "RBL2"      "RBM14"     "RBM8A"    
##  [571] "RELA"      "REST"      "RET"       "RETN"      "RFC2"      "RFC3"     
##  [577] "RFC4"      "RFC5"      "RFFL"      "RGCC"      "RHEB"      "RHNO1"    
##  [583] "RICTOR"    "RING1"     "RMI1"      "RNF111"    "RNF2"      "RNF34"    
##  [589] "RNGTT"     "RNMT"      "RORA"      "RORB"      "RORC"      "RPA1"     
##  [595] "RPA2"      "RPA3"      "RPAP2"     "RPRD1A"    "RPRD1B"    "RPRD2"    
##  [601] "RPS27A"    "RPTOR"     "RRAGA"     "RRAGB"     "RRAGC"     "RRAGD"    
##  [607] "RRM2"      "RRM2B"     "RTF1"      "RUNX1"     "RUNX3"     "RXRA"     
##  [613] "RXRB"      "SARNP"     "SATB2"     "SCMH1"     "SCO2"      "SEM1"     
##  [619] "SESN2"     "SESN3"     "SETD1A"    "SETD1B"    "SETD9"     "SFN"      
##  [625] "SGK1"      "SIN3A"     "SIN3B"     "SIRT1"     "SIRT3"     "SKI"      
##  [631] "SKIL"      "SKP1"      "SKP2"      "SLBP"      "SLC2A3"    "SLC38A9"  
##  [637] "SLU7"      "SMAD2"     "SMAD3"     "SMAD4"     "SMAD6"     "SMAD7"    
##  [643] "SMARCA2"   "SMARCA4"   "SMARCB1"   "SMARCC1"   "SMARCC2"   "SMARCD1"  
##  [649] "SMARCD2"   "SMARCD3"   "SMARCE1"   "SMURF1"    "SMURF2"    "SMYD2"    
##  [655] "SNAPC1"    "SNAPC2"    "SNAPC3"    "SNAPC4"    "SNAPC5"    "SNRPB"    
##  [661] "SNRPD3"    "SNRPE"     "SNRPF"     "SNRPG"     "SNW1"      "SOCS3"    
##  [667] "SOCS4"     "SOD2"      "SP1"       "SPI1"      "SPP1"      "SRC"      
##  [673] "SREBF1"    "SRF"       "SRRM1"     "SRRT"      "SRSF1"     "SRSF11"   
##  [679] "SRSF2"     "SRSF3"     "SRSF4"     "SRSF5"     "SRSF6"     "SRSF7"    
##  [685] "SRSF9"     "SSRP1"     "SSU72"     "STAT1"     "STK11"     "STUB1"    
##  [691] "SUMO1"     "SUPT16H"   "SUPT4H1"   "SUPT5H"    "SUPT6H"    "SUZ12"    
##  [697] "SYMPK"     "TAF1"      "TAF10"     "TAF11"     "TAF12"     "TAF13"    
##  [703] "TAF15"     "TAF2"      "TAF3"      "TAF4"      "TAF4B"     "TAF5"     
##  [709] "TAF6"      "TAF7"      "TAF9"      "TAF9B"     "TBL1X"     "TBL1XR1"  
##  [715] "TBP"       "TCEA1"     "TCF12"     "TCF3"      "TCF7"      "TCF7L1"   
##  [721] "TCF7L2"    "TEAD2"     "TFAP2E"    "TFDP1"     "TFDP2"     "TGFA"     
##  [727] "TGFB1"     "TGIF1"     "TGIF2"     "THOC1"     "THOC2"     "THOC3"    
##  [733] "THOC5"     "THOC6"     "THOC7"     "THRA"      "TIGAR"     "TJP1"     
##  [739] "TMEM219"   "TNFRSF10A" "TNFRSF10B" "TNFRSF10C" "TNFRSF10D" "TNFRSF18" 
##  [745] "TNKS1BP1"  "TNRC6A"    "TNRC6B"    "TNRC6C"    "TOP3A"     "TOPBP1"   
##  [751] "TP53"      "TP53I3"    "TP53RK"    "TP63"      "TP73"      "TPX2"     
##  [757] "TRIAP1"    "TRIM28"    "TRIM33"    "TRPC3"     "TSC1"      "TSC2"     
##  [763] "TTC5"      "TXNRD1"    "U2AF1"     "U2AF1L4"   "U2AF2"     "UBA52"    
##  [769] "UBB"       "UBE2D1"    "UBE2D3"    "UBE2E1"    "UBE2I"     "UBE2S"    
##  [775] "UPF3B"     "USP7"      "USP9X"     "UXT"       "VDR"       "VEGFA"    
##  [781] "VENTX"     "WDR33"     "WRN"       "WWOX"      "WWP1"      "WWTR1"    
##  [787] "XPO1"      "YAF2"      "YBX1"      "YEATS4"    "YES1"      "YWHAB"    
##  [793] "YWHAE"     "YWHAH"     "YY1"       "ZC3H11A"   "ZC3H8"     "ZFHX3"    
##  [799] "ZFP1"      "ZFP14"     "ZFP2"      "ZFP28"     "ZFP30"     "ZFP37"    
##  [805] "ZFP69"     "ZFP69B"    "ZFP90"     "ZIK1"      "ZKSCAN1"   "ZKSCAN3"  
##  [811] "ZKSCAN4"   "ZKSCAN5"   "ZKSCAN7"   "ZKSCAN8"   "ZNF10"     "ZNF100"   
##  [817] "ZNF101"    "ZNF112"    "ZNF12"     "ZNF124"    "ZNF133"    "ZNF135"   
##  [823] "ZNF136"    "ZNF138"    "ZNF14"     "ZNF140"    "ZNF141"    "ZNF143"   
##  [829] "ZNF154"    "ZNF155"    "ZNF157"    "ZNF160"    "ZNF169"    "ZNF17"    
##  [835] "ZNF175"    "ZNF18"     "ZNF180"    "ZNF184"    "ZNF189"    "ZNF19"    
##  [841] "ZNF195"    "ZNF197"    "ZNF2"      "ZNF20"     "ZNF200"    "ZNF202"   
##  [847] "ZNF205"    "ZNF208"    "ZNF211"    "ZNF212"    "ZNF213"    "ZNF221"   
##  [853] "ZNF222"    "ZNF223"    "ZNF224"    "ZNF225"    "ZNF226"    "ZNF227"   
##  [859] "ZNF23"     "ZNF230"    "ZNF233"    "ZNF234"    "ZNF235"    "ZNF248"   
##  [865] "ZNF25"     "ZNF250"    "ZNF253"    "ZNF254"    "ZNF256"    "ZNF257"   
##  [871] "ZNF26"     "ZNF263"    "ZNF264"    "ZNF266"    "ZNF267"    "ZNF268"   
##  [877] "ZNF273"    "ZNF274"    "ZNF28"     "ZNF282"    "ZNF285"    "ZNF286A"  
##  [883] "ZNF287"    "ZNF3"      "ZNF30"     "ZNF300"    "ZNF302"    "ZNF304"   
##  [889] "ZNF311"    "ZNF317"    "ZNF320"    "ZNF324"    "ZNF324B"   "ZNF331"   
##  [895] "ZNF333"    "ZNF334"    "ZNF337"    "ZNF33A"    "ZNF33B"    "ZNF34"    
##  [901] "ZNF347"    "ZNF350"    "ZNF354A"   "ZNF354B"   "ZNF354C"   "ZNF37A"   
##  [907] "ZNF382"    "ZNF383"    "ZNF385A"   "ZNF394"    "ZNF398"    "ZNF41"    
##  [913] "ZNF415"    "ZNF416"    "ZNF417"    "ZNF418"    "ZNF419"    "ZNF420"   
##  [919] "ZNF425"    "ZNF426"    "ZNF429"    "ZNF43"     "ZNF430"    "ZNF431"   
##  [925] "ZNF432"    "ZNF433"    "ZNF436"    "ZNF439"    "ZNF440"    "ZNF441"   
##  [931] "ZNF442"    "ZNF443"    "ZNF445"    "ZNF446"    "ZNF45"     "ZNF460"   
##  [937] "ZNF461"    "ZNF468"    "ZNF470"    "ZNF473"    "ZNF479"    "ZNF480"   
##  [943] "ZNF483"    "ZNF484"    "ZNF485"    "ZNF486"    "ZNF490"    "ZNF492"   
##  [949] "ZNF493"    "ZNF496"    "ZNF500"    "ZNF506"    "ZNF510"    "ZNF514"   
##  [955] "ZNF517"    "ZNF519"    "ZNF521"    "ZNF528"    "ZNF529"    "ZNF530"   
##  [961] "ZNF540"    "ZNF543"    "ZNF544"    "ZNF546"    "ZNF547"    "ZNF548"   
##  [967] "ZNF549"    "ZNF550"    "ZNF551"    "ZNF552"    "ZNF554"    "ZNF555"   
##  [973] "ZNF556"    "ZNF557"    "ZNF558"    "ZNF559"    "ZNF561"    "ZNF563"   
##  [979] "ZNF564"    "ZNF565"    "ZNF566"    "ZNF567"    "ZNF568"    "ZNF569"   
##  [985] "ZNF570"    "ZNF571"    "ZNF573"    "ZNF577"    "ZNF582"    "ZNF583"   
##  [991] "ZNF584"    "ZNF585A"   "ZNF585B"   "ZNF586"    "ZNF587"    "ZNF589"   
##  [997] "ZNF595"    "ZNF596"    "ZNF597"    "ZNF599"    "ZNF600"    "ZNF605"   
## [1003] "ZNF606"    "ZNF607"    "ZNF610"    "ZNF611"    "ZNF613"    "ZNF614"   
## [1009] "ZNF615"    "ZNF616"    "ZNF619"    "ZNF620"    "ZNF621"    "ZNF624"   
## [1015] "ZNF625"    "ZNF626"    "ZNF627"    "ZNF641"    "ZNF649"    "ZNF655"   
## [1021] "ZNF658"    "ZNF658B"   "ZNF660"    "ZNF662"    "ZNF664"    "ZNF665"   
## [1027] "ZNF667"    "ZNF668"    "ZNF669"    "ZNF670"    "ZNF671"    "ZNF675"   
## [1033] "ZNF676"    "ZNF677"    "ZNF678"    "ZNF680"    "ZNF681"    "ZNF682"   
## [1039] "ZNF684"    "ZNF688"    "ZNF689"    "ZNF691"    "ZNF692"    "ZNF696"   
## [1045] "ZNF697"    "ZNF699"    "ZNF70"     "ZNF700"    "ZNF701"    "ZNF702P"  
## [1051] "ZNF703"    "ZNF704"    "ZNF707"    "ZNF708"    "ZNF709"    "ZNF71"    
## [1057] "ZNF710"    "ZNF711"    "ZNF713"    "ZNF714"    "ZNF716"    "ZNF717"   
## [1063] "ZNF718"    "ZNF721"    "ZNF724"    "ZNF726"    "ZNF726P1"  "ZNF727"   
## [1069] "ZNF736"    "ZNF737"    "ZNF738"    "ZNF74"     "ZNF740"    "ZNF746"   
## [1075] "ZNF747"    "ZNF749"    "ZNF75A"    "ZNF75D"    "ZNF761"    "ZNF764"   
## [1081] "ZNF767P"   "ZNF77"     "ZNF770"    "ZNF771"    "ZNF772"    "ZNF773"   
## [1087] "ZNF774"    "ZNF775"    "ZNF776"    "ZNF777"    "ZNF778"    "ZNF782"   
## [1093] "ZNF785"    "ZNF786"    "ZNF79"     "ZNF790"    "ZNF791"    "ZNF792"   
## [1099] "ZNF793"    "ZNF799"    "ZNF839"    "ZNF860"    "ZNF92"     "ZNF99"    
## [1105] "ZSCAN25"   "ZSCAN32"  
## 
## [[1]]$`DOWN genesets.Regulation of Expression and Function of Type II Classical Cadherins`
##  [1] "ADAM19"  "ADAM33"  "AGO1"    "AGO2"    "AGO3"    "AGO4"    "AMOT"   
##  [8] "ANGPTL4" "CDH24"   "CDH8"    "CTNNA1"  "CTNNB1"  "CTNND1"  "ILF3"   
## [15] "JUP"     "MOV10"   "PRDM8"   "SNAI1"   "SOX10"   "SP1"     "TNRC6A" 
## [22] "TNRC6B"  "TNRC6C"  "ZC3H12A" "ZEB2"   
## 
## [[1]]$`DOWN genesets.Regulation of Homotypic Cell-Cell Adhesion`
##  [1] "ADAM19"  "ADAM33"  "AGO1"    "AGO2"    "AGO3"    "AGO4"    "AMOT"   
##  [8] "ANGPTL4" "CDH24"   "CDH8"    "CTNNA1"  "CTNNB1"  "CTNND1"  "ILF3"   
## [15] "JUP"     "MOV10"   "PRDM8"   "SNAI1"   "SOX10"   "SP1"     "TNRC6A" 
## [22] "TNRC6B"  "TNRC6C"  "ZC3H12A" "ZEB2"   
## 
## [[1]]$`DOWN genesets.Resolution of AP sites via the multiple-nucleotide patch replacement pathway`
##  [1] "ADPRS" "APEX1" "FEN1"  "LIG1"  "PARG"  "PARP1" "PARP2" "PCNA"  "POLB" 
## [10] "POLD1" "POLD2" "POLD3" "POLD4" "POLE"  "POLE2" "POLE3" "POLE4" "RFC1" 
## [19] "RFC2"  "RFC3"  "RFC4"  "RFC5"  "RPA1"  "RPA2"  "RPA3" 
## 
## [[1]]$`DOWN genesets.Resolution of Abasic Sites (AP sites)`
##  [1] "ADPRS" "APEX1" "FEN1"  "LIG1"  "LIG3"  "MBD4"  "MPG"   "MUTYH" "NEIL1"
## [10] "NEIL2" "NTHL1" "OGG1"  "PARG"  "PARP1" "PARP2" "PCNA"  "PNKP"  "POLB" 
## [19] "POLD1" "POLD2" "POLD3" "POLD4" "POLE"  "POLE2" "POLE3" "POLE4" "RFC1" 
## [28] "RFC2"  "RFC3"  "RFC4"  "RFC5"  "RPA1"  "RPA2"  "RPA3"  "SMUG1" "TDG"  
## [37] "XRCC1"
## 
## [[1]]$`DOWN genesets.SUMO E3 ligases SUMOylate target proteins`
##   [1] "AAAS"     "AR"       "AURKA"    "AURKB"    "BIRC5"    "BMI1"    
##   [7] "BRCA1"    "CASP8AP2" "CBX2"     "CBX4"     "CBX5"     "CBX8"    
##  [13] "CDCA8"    "CDKN2A"   "CETN2"    "CHD3"     "CREBBP"   "CTBP1"   
##  [19] "DAXX"     "DDX17"    "DDX5"     "DNMT1"    "DNMT3A"   "DNMT3B"  
##  [25] "EID3"     "EIF2AK2"  "EP300"    "ESR1"     "HDAC1"    "HDAC2"   
##  [31] "HDAC7"    "HERC2"    "HIC1"     "HNRNPC"   "IKBKE"    "IKBKG"   
##  [37] "INCENP"   "ING2"     "L3MBTL2"  "MBD1"     "MDC1"     "MITF"    
##  [43] "MRTFA"    "MTA1"     "NCOA1"    "NCOA2"    "NCOR2"    "NDC1"    
##  [49] "NFKB2"    "NOP58"    "NPM1"     "NR1H2"    "NR1H3"    "NR1I2"   
##  [55] "NR2C1"    "NR3C1"    "NR3C2"    "NR4A2"    "NRIP1"    "NSMCE1"  
##  [61] "NSMCE2"   "NSMCE3"   "NSMCE4A"  "NUP107"   "NUP133"   "NUP153"  
##  [67] "NUP155"   "NUP160"   "NUP188"   "NUP205"   "NUP210"   "NUP214"  
##  [73] "NUP35"    "NUP37"    "NUP42"    "NUP43"    "NUP50"    "NUP54"   
##  [79] "NUP62"    "NUP85"    "NUP88"    "NUP93"    "NUP98"    "PARK7"   
##  [85] "PARP1"    "PCGF2"    "PCNA"     "PHC1"     "PHC3"     "PIAS1"   
##  [91] "PIAS3"    "PIAS4"    "PML"      "POM121"   "POM121C"  "PPARA"   
##  [97] "RAD21"    "RAD52"    "RAE1"     "RANBP2"   "RANGAP1"  "RARA"    
## [103] "RELA"     "RING1"    "RNF168"   "RNF2"     "RORA"     "RPA1"    
## [109] "RXRA"     "SAFB"     "SATB1"    "SATB2"    "SCMH1"    "SEC13"   
## [115] "SEH1L"    "SIN3A"    "SMC1A"    "SMC3"     "SMC5"     "SMC6"    
## [121] "SP3"      "STAG1"    "STAG2"    "SUMO1"    "SUMO2"    "SUMO3"   
## [127] "SUZ12"    "TDG"      "THRA"     "TOP1"     "TOP2A"    "TOP2B"   
## [133] "TOPORS"   "TP53"     "TP53BP1"  "TPR"      "TRIM27"   "TRIM28"  
## [139] "UBE2I"    "UHRF2"    "VDR"      "VHL"      "WRN"      "XPC"     
## [145] "XRCC4"    "ZBED1"    "ZNF131"   "ZNF350"  
## 
## [[1]]$`DOWN genesets.TGFBR3 expression`
##  [1] "AGO1"   "AGO2"   "AGO3"   "AGO4"   "EP300"  "HELLS"  "KLF16"  "MOV10" 
##  [9] "RARA"   "RXRA"   "SMAD3"  "SMAD4"  "SP1"    "TCF12"  "TCF3"   "TCF4"  
## [17] "TGFBR3" "TNRC6A" "TNRC6B" "TNRC6C"
## 
## [[1]]$`DOWN genesets.Translocation of ZAP-70 to Immunological synapse`
##  [1] "CD247"     "CD3D"      "CD3E"      "CD4"       "HLA-DPA1"  "HLA-DPB1" 
##  [7] "HLA-DQA1"  "HLA-DQA2"  "HLA-DQB1"  "HLA-DQB2"  "HLA-DRA"   "HLA-DRB1" 
## [13] "HLA-DRB5"  "LCK"       "PTPN22"    "TRAC"      "TRAV19"    "TRAV29DV5"
## [19] "TRAV8-4"   "TRBC1"     "TRBV12-3"  "TRBV7-9"   "ZAP70"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report