date generated: 2026-05-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 1.6447687
A1BG -0.7426575
A1BG-AS1 -0.1261055
A1CF 0.0456119
A2M 1.6576371
A2M-AS1 2.2028837

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21870
duplicated_genes_present 0
num_profile_genes_in_sets 8802
num_profile_genes_not_in_sets 13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1189
num_genesets_included 1536

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Regulation of NFE2L2 gene expression 8 2.87e-05 -0.854 7.56e-04
MECP2 regulates transcription of neuronal ligands 5 3.35e-03 -0.757 2.90e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 5.22e-04 -0.757 7.53e-03
Phosphorylation of Emi1 6 1.79e-03 -0.736 1.86e-02
NFE2L2 regulating inflammation associated genes 5 4.68e-03 -0.730 3.77e-02
Interleukin-21 signaling 9 2.26e-04 -0.710 4.21e-03
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.18e-03 -0.708 1.40e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 6.93e-03 -0.697 5.05e-02
CYP2E1 reactions 5 8.36e-03 -0.681 5.97e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.17e-03 -0.663 1.40e-02
Eicosanoids 8 1.86e-03 0.635 1.90e-02
Diseases of Base Excision Repair 5 1.58e-02 -0.623 1.00e-01
Disorders of Developmental Biology 12 2.04e-04 -0.619 3.92e-03
Disorders of Nervous System Development 12 2.04e-04 -0.619 3.92e-03
Loss of function of MECP2 in Rett syndrome 12 2.04e-04 -0.619 3.92e-03
Pervasive developmental disorders 12 2.04e-04 -0.619 3.92e-03
Defective LFNG causes SCDO3 5 1.91e-02 -0.605 1.14e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 3.41e-03 -0.598 2.93e-02
Type I hemidesmosome assembly 8 3.42e-03 -0.598 2.93e-02
Acetylcholine binding and downstream events 5 2.13e-02 -0.595 1.23e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.13e-02 -0.595 1.23e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 2.07e-08 -0.572 1.66e-06
Interleukin-9 signaling 8 6.08e-03 -0.560 4.56e-02
Biosynthesis of EPA-derived SPMs 6 1.84e-02 0.556 1.12e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.12e-02 -0.554 7.59e-02
Processive synthesis on the C-strand of the telomere 19 5.32e-05 -0.535 1.33e-03
Activation of PUMA and translocation to mitochondria 9 5.66e-03 -0.533 4.28e-02
Removal of the Flap Intermediate from the C-strand 17 1.49e-04 -0.531 3.14e-03
Cross-presentation of particulate exogenous antigens (phagosomes) 8 9.73e-03 0.528 6.67e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 1.57e-02 -0.527 9.94e-02
Interleukin-2 signaling 11 2.49e-03 -0.527 2.34e-02
Unwinding of DNA 12 1.74e-03 -0.522 1.84e-02
Scavenging by Class F Receptors 5 4.43e-02 -0.519 2.02e-01
NR1H2 and NR1H3-mediated signaling 38 3.36e-08 -0.517 2.40e-06
Formation of the ureteric bud 5 4.63e-02 0.515 2.08e-01
Passive transport by Aquaporins 6 3.21e-02 0.505 1.65e-01
NFE2L2 regulating MDR associated enzymes 8 1.54e-02 -0.495 9.93e-02
HDMs demethylate histones 22 6.30e-05 -0.493 1.50e-03
STAT3 nuclear events downstream of ALK signaling 11 4.74e-03 -0.492 3.77e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.07e-04 -0.491 5.31e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 2.58e-02 -0.487 1.41e-01
TGFBR3 regulates TGF-beta signaling 8 1.74e-02 -0.485 1.06e-01
NFE2L2 regulating ER-stress associated genes 5 6.01e-02 -0.485 2.49e-01
Repression of WNT target genes 14 2.30e-03 -0.471 2.21e-02
Interleukin-23 signaling 7 3.24e-02 -0.467 1.66e-01
Biosynthesis of E-series 18(S)-resolvins 5 7.06e-02 0.467 2.74e-01
HDR through MMEJ (alt-NHEJ) 12 5.18e-03 -0.466 4.01e-02
Regulation of TP53 Activity through Acetylation 29 1.54e-05 -0.464 4.88e-04
Nef and signal transduction 8 2.37e-02 -0.462 1.32e-01
HDL remodeling 6 5.11e-02 -0.460 2.26e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Regulation of NFE2L2 gene expression 8 2.87e-05 -0.854000 7.56e-04
MECP2 regulates transcription of neuronal ligands 5 3.35e-03 -0.757000 2.90e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 5.22e-04 -0.757000 7.53e-03
Phosphorylation of Emi1 6 1.79e-03 -0.736000 1.86e-02
NFE2L2 regulating inflammation associated genes 5 4.68e-03 -0.730000 3.77e-02
Interleukin-21 signaling 9 2.26e-04 -0.710000 4.21e-03
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.18e-03 -0.708000 1.40e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 6.93e-03 -0.697000 5.05e-02
CYP2E1 reactions 5 8.36e-03 -0.681000 5.97e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.17e-03 -0.663000 1.40e-02
Eicosanoids 8 1.86e-03 0.635000 1.90e-02
Diseases of Base Excision Repair 5 1.58e-02 -0.623000 1.00e-01
Disorders of Developmental Biology 12 2.04e-04 -0.619000 3.92e-03
Disorders of Nervous System Development 12 2.04e-04 -0.619000 3.92e-03
Loss of function of MECP2 in Rett syndrome 12 2.04e-04 -0.619000 3.92e-03
Pervasive developmental disorders 12 2.04e-04 -0.619000 3.92e-03
Defective LFNG causes SCDO3 5 1.91e-02 -0.605000 1.14e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 3.41e-03 -0.598000 2.93e-02
Type I hemidesmosome assembly 8 3.42e-03 -0.598000 2.93e-02
Acetylcholine binding and downstream events 5 2.13e-02 -0.595000 1.23e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.13e-02 -0.595000 1.23e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 2.07e-08 -0.572000 1.66e-06
Interleukin-9 signaling 8 6.08e-03 -0.560000 4.56e-02
Biosynthesis of EPA-derived SPMs 6 1.84e-02 0.556000 1.12e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.12e-02 -0.554000 7.59e-02
Processive synthesis on the C-strand of the telomere 19 5.32e-05 -0.535000 1.33e-03
Activation of PUMA and translocation to mitochondria 9 5.66e-03 -0.533000 4.28e-02
Removal of the Flap Intermediate from the C-strand 17 1.49e-04 -0.531000 3.14e-03
Cross-presentation of particulate exogenous antigens (phagosomes) 8 9.73e-03 0.528000 6.67e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 1.57e-02 -0.527000 9.94e-02
Interleukin-2 signaling 11 2.49e-03 -0.527000 2.34e-02
Unwinding of DNA 12 1.74e-03 -0.522000 1.84e-02
Scavenging by Class F Receptors 5 4.43e-02 -0.519000 2.02e-01
NR1H2 and NR1H3-mediated signaling 38 3.36e-08 -0.517000 2.40e-06
Formation of the ureteric bud 5 4.63e-02 0.515000 2.08e-01
Passive transport by Aquaporins 6 3.21e-02 0.505000 1.65e-01
NFE2L2 regulating MDR associated enzymes 8 1.54e-02 -0.495000 9.93e-02
HDMs demethylate histones 22 6.30e-05 -0.493000 1.50e-03
STAT3 nuclear events downstream of ALK signaling 11 4.74e-03 -0.492000 3.77e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.07e-04 -0.491000 5.31e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 2.58e-02 -0.487000 1.41e-01
TGFBR3 regulates TGF-beta signaling 8 1.74e-02 -0.485000 1.06e-01
NFE2L2 regulating ER-stress associated genes 5 6.01e-02 -0.485000 2.49e-01
Repression of WNT target genes 14 2.30e-03 -0.471000 2.21e-02
Interleukin-23 signaling 7 3.24e-02 -0.467000 1.66e-01
Biosynthesis of E-series 18(S)-resolvins 5 7.06e-02 0.467000 2.74e-01
HDR through MMEJ (alt-NHEJ) 12 5.18e-03 -0.466000 4.01e-02
Regulation of TP53 Activity through Acetylation 29 1.54e-05 -0.464000 4.88e-04
Nef and signal transduction 8 2.37e-02 -0.462000 1.32e-01
HDL remodeling 6 5.11e-02 -0.460000 2.26e-01
Zygotic genome activation (ZGA) 5 7.57e-02 -0.459000 2.86e-01
APOBEC3G mediated resistance to HIV-1 infection 5 7.58e-02 -0.459000 2.86e-01
RORA activates gene expression 18 7.84e-04 -0.457000 1.01e-02
Histidine catabolism 7 3.66e-02 0.456000 1.79e-01
Protein repair 6 5.70e-02 0.449000 2.40e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 5 8.47e-02 0.445000 3.07e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 4.14e-03 0.443000 3.42e-02
Acyl chain remodelling of PI 10 1.56e-02 0.442000 9.93e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 8.77e-02 -0.441000 3.17e-01
Processive synthesis on the lagging strand 15 3.13e-03 -0.441000 2.73e-02
TRAF3-dependent IRF activation pathway 13 6.20e-03 -0.438000 4.59e-02
Activation of NOXA and translocation to mitochondria 5 9.07e-02 -0.437000 3.22e-01
Cardiogenesis 14 4.78e-03 -0.435000 3.78e-02
Bicarbonate transporters 9 2.40e-02 -0.434000 1.34e-01
ChREBP activates metabolic gene expression 7 4.78e-02 -0.432000 2.13e-01
Removal of the Flap Intermediate 14 5.23e-03 -0.431000 4.01e-02
Tandem pore domain potassium channels 5 9.57e-02 -0.430000 3.32e-01
Signaling by ALK 24 2.71e-04 -0.429000 4.84e-03
PTK6 promotes HIF1A stabilization 6 6.86e-02 0.429000 2.71e-01
Acetylcholine Neurotransmitter Release Cycle 10 1.91e-02 -0.428000 1.14e-01
Polo-like kinase mediated events 16 3.06e-03 -0.428000 2.69e-02
Regulation of TP53 Activity through Association with Co-factors 13 7.83e-03 -0.426000 5.63e-02
Expression and translocation of olfactory receptors 52 1.21e-07 0.424000 6.13e-06
Keratan sulfate degradation 9 2.77e-02 0.424000 1.49e-01
Suppression of apoptosis 7 5.26e-02 -0.423000 2.29e-01
Synthesis of PG 8 3.83e-02 -0.423000 1.82e-01
Formation of annular gap junctions 10 2.12e-02 -0.421000 1.23e-01
Mitotic Telophase/Cytokinesis 13 8.68e-03 -0.420000 6.13e-02
G2/M DNA replication checkpoint 5 1.04e-01 -0.419000 3.51e-01
Biosynthesis of Lipoxins (LX) 6 7.66e-02 0.417000 2.87e-01
SUMOylation of DNA replication proteins 46 1.08e-06 -0.415000 4.75e-05
Pre-NOTCH Processing in Golgi 18 2.29e-03 -0.415000 2.21e-02
TGFBR3 expression 20 1.31e-03 -0.415000 1.51e-02
Maturation of protein 3a 9683673 9 3.19e-02 -0.413000 1.64e-01
Maturation of protein 3a 9694719 9 3.19e-02 -0.413000 1.64e-01
Serotonin Neurotransmitter Release Cycle 13 1.10e-02 -0.407000 7.50e-02
CD22 mediated BCR regulation 59 7.58e-08 -0.405000 4.57e-06
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 8.76e-03 -0.405000 6.16e-02
HSF1-dependent transactivation 30 1.31e-04 -0.403000 2.87e-03
Maturation of spike protein 9683686 5 1.19e-01 -0.402000 3.88e-01
Condensation of Prometaphase Chromosomes 11 2.20e-02 -0.399000 1.26e-01
Nef Mediated CD4 Down-regulation 9 3.82e-02 -0.399000 1.82e-01
WNT5A-dependent internalization of FZD4 13 1.28e-02 -0.399000 8.49e-02
Norepinephrine Neurotransmitter Release Cycle 12 1.69e-02 -0.398000 1.04e-01
G0 and Early G1 27 3.42e-04 -0.398000 5.54e-03
Signal attenuation 9 3.92e-02 0.397000 1.85e-01
PTK6 Regulates Cell Cycle 6 9.33e-02 -0.396000 3.28e-01
Other interleukin signaling 19 2.91e-03 -0.395000 2.58e-02
PD-1 signaling 28 3.34e-04 -0.392000 5.49e-03
Activation of the AP-1 family of transcription factors 10 3.27e-02 0.390000 1.66e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 9.86e-02 0.389000 3.36e-01
Regulation of MECP2 expression and activity 29 2.92e-04 -0.389000 5.16e-03
H139Hfs13* PPM1K causes a mild variant of MSUD 5 1.35e-01 0.386000 4.21e-01
Maple Syrup Urine Disease 5 1.35e-01 0.386000 4.21e-01
Interleukin-20 family signaling 17 6.32e-03 -0.383000 4.66e-02
Classical antibody-mediated complement activation 70 3.14e-08 -0.382000 2.32e-06
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 4.71e-02 0.382000 2.11e-01
Synthesis of GDP-mannose 6 1.06e-01 -0.381000 3.55e-01
Nef Mediated CD8 Down-regulation 7 8.09e-02 -0.381000 2.98e-01
Carnitine shuttle 12 2.24e-02 -0.381000 1.28e-01
Regulation of HMOX1 expression and activity 5 1.41e-01 -0.380000 4.33e-01
Olfactory Signaling Pathway 57 7.80e-07 0.378000 3.58e-05
Telomere C-strand synthesis initiation 13 1.87e-02 -0.376000 1.13e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.35e-03 -0.375000 6.46e-02
Abacavir ADME 5 1.48e-01 -0.374000 4.39e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 1.49e-01 -0.373000 4.39e-01
Activation of SMO 14 1.60e-02 -0.372000 1.01e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.13e-04 -0.372000 2.54e-03
Coenzyme A biosynthesis 7 8.91e-02 -0.371000 3.19e-01
Role of phospholipids in phagocytosis 89 1.44e-09 -0.371000 1.46e-07
Scavenging of heme from plasma 71 7.30e-08 -0.369000 4.54e-06
DNA strand elongation 32 3.23e-04 -0.367000 5.46e-03
FCGR activation 77 2.55e-08 -0.367000 1.97e-06
G1/S-Specific Transcription 29 6.80e-04 -0.364000 8.98e-03
Lysosphingolipid and LPA receptors 11 3.65e-02 -0.364000 1.79e-01
Telomere C-strand (Lagging Strand) Synthesis 34 2.49e-04 -0.363000 4.52e-03
Uptake of dietary cobalamins into enterocytes 6 1.24e-01 -0.363000 3.95e-01
Defective RIPK1-mediated regulated necrosis 7 9.71e-02 -0.362000 3.35e-01
SARS-CoV-2 modulates autophagy 11 3.82e-02 -0.361000 1.82e-01
Evasion by RSV of host interferon responses 20 5.22e-03 -0.361000 4.01e-02
Creation of C4 and C2 activators 72 1.20e-07 -0.361000 6.13e-06
Attenuation phase 23 2.76e-03 -0.360000 2.52e-02
Rev-mediated nuclear export of HIV RNA 35 2.26e-04 -0.360000 4.21e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.98e-02 -0.360000 1.17e-01
Pausing and recovery of Tat-mediated HIV elongation 30 6.62e-04 -0.359000 8.85e-03
Tat-mediated HIV elongation arrest and recovery 30 6.62e-04 -0.359000 8.85e-03
Nucleotide biosynthesis 12 3.16e-02 -0.358000 1.64e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 4.63e-04 -0.358000 6.80e-03
Gap junction degradation 11 4.11e-02 -0.356000 1.92e-01
RUNX1 regulates expression of components of tight junctions 5 1.69e-01 0.355000 4.76e-01
Nuclear import of Rev protein 34 3.41e-04 -0.355000 5.54e-03
Vpr-mediated nuclear import of PICs 34 3.59e-04 -0.354000 5.68e-03
Crosslinking of collagen fibrils 13 2.77e-02 0.353000 1.49e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 1.35e-01 -0.353000 4.21e-01
SUMOylation of SUMOylation proteins 35 3.06e-04 -0.353000 5.31e-03
Export of Viral Ribonucleoproteins from Nucleus 33 4.73e-04 -0.352000 6.90e-03
Viral Messenger RNA Synthesis 44 5.82e-05 -0.350000 1.42e-03
Interactions of Rev with host cellular proteins 37 2.31e-04 -0.350000 4.24e-03
HIV elongation arrest and recovery 32 6.31e-04 -0.349000 8.61e-03
Pausing and recovery of HIV elongation 32 6.31e-04 -0.349000 8.61e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 6.31e-04 -0.349000 8.61e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 6.31e-04 -0.349000 8.61e-03
IFNG signaling activates MAPKs 8 8.93e-02 0.347000 3.19e-01
Transcription of E2F targets under negative control by DREAM complex 19 8.89e-03 -0.347000 6.23e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 2.74e-03 -0.346000 2.52e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 1.81e-01 -0.346000 4.96e-01
SUMOylation of immune response proteins 12 3.84e-02 -0.345000 1.82e-01
Translocation of ZAP-70 to Immunological synapse 24 3.48e-03 -0.344000 2.96e-02
Glycosphingolipid transport 7 1.15e-01 -0.344000 3.81e-01
XBP1(S) activates chaperone genes 44 7.83e-05 -0.344000 1.84e-03
Initial triggering of complement 80 1.04e-07 -0.344000 5.89e-06
Assembly Of The HIV Virion 15 2.18e-02 -0.342000 1.26e-01
RHOBTB3 ATPase cycle 10 6.17e-02 -0.341000 2.53e-01
Extension of Telomeres 51 2.85e-05 -0.339000 7.56e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 2.82e-02 -0.339000 1.51e-01
Resolution of Abasic Sites (AP sites) 38 3.09e-04 -0.338000 5.31e-03
FCGR3A-mediated IL10 synthesis 100 5.26e-09 -0.338000 4.61e-07
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.03e-03 -0.335000 1.27e-02
Phosphorylation of CD3 and TCR zeta chains 27 2.73e-03 -0.333000 2.52e-02
Activation of the pre-replicative complex 32 1.18e-03 -0.331000 1.40e-02
Regulation of NPAS4 gene expression 11 5.72e-02 -0.331000 2.41e-01
Telomere Extension By Telomerase 23 6.13e-03 -0.330000 4.58e-02
Glycine degradation 7 1.31e-01 -0.330000 4.12e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 3.96e-02 0.330000 1.86e-01
Nuclear events stimulated by ALK signaling in cancer 33 1.16e-03 -0.327000 1.40e-02
SUMOylation of ubiquitinylation proteins 39 4.15e-04 -0.327000 6.20e-03
Fatty acids 8 1.10e-01 0.326000 3.66e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.10e-01 -0.326000 3.67e-01
Regulation of NPAS4 mRNA translation 8 1.10e-01 -0.326000 3.67e-01
Retrograde neurotrophin signalling 12 5.07e-02 -0.326000 2.25e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.96e-03 -0.325000 5.06e-02
IRE1alpha activates chaperones 46 1.38e-04 -0.325000 2.98e-03
TBC/RABGAPs 45 1.68e-04 -0.324000 3.38e-03
Membrane binding and targetting of GAG proteins 13 4.34e-02 -0.324000 1.99e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 4.34e-02 -0.324000 1.99e-01
HSF1 activation 26 4.47e-03 -0.322000 3.65e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 6.45e-02 -0.322000 2.60e-01
Recycling of bile acids and salts 10 7.80e-02 -0.322000 2.90e-01
N-Glycan antennae elongation 13 4.46e-02 -0.322000 2.03e-01
GABA synthesis, release, reuptake and degradation 11 6.53e-02 -0.321000 2.61e-01
Mismatch Repair 15 3.16e-02 -0.320000 1.64e-01
Androgen biosynthesis 5 2.15e-01 0.320000 5.48e-01
Deactivation of the beta-catenin transactivating complex 36 8.95e-04 -0.320000 1.14e-02
Role of LAT2/NTAL/LAB on calcium mobilization 78 1.09e-06 -0.319000 4.75e-05
ARMS-mediated activation 6 1.76e-01 0.319000 4.89e-01
FCERI mediated Ca+2 mobilization 93 1.08e-07 -0.319000 5.97e-06
Hydrolysis of LPC 8 1.19e-01 0.319000 3.88e-01
Interactions of Vpr with host cellular proteins 37 8.24e-04 -0.318000 1.05e-02
Synthesis of 5-eicosatetraenoic acids 7 1.48e-01 0.316000 4.39e-01
Transport of the SLBP Dependant Mature mRNA 36 1.06e-03 -0.315000 1.29e-02
SOS-mediated signalling 7 1.49e-01 0.315000 4.39e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 1.81e-01 -0.315000 4.97e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 4.04e-03 -0.314000 3.37e-02
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.94e-03 -0.314000 2.60e-02
N-glycan trimming and elongation in the cis-Golgi 5 2.25e-01 -0.313000 5.61e-01
Synthesis of PI 5 2.27e-01 -0.312000 5.64e-01
Postmitotic nuclear pore complex (NPC) reformation 27 5.38e-03 -0.309000 4.11e-02
Interleukin-15 signaling 14 4.56e-02 -0.309000 2.06e-01
ROBO receptors bind AKAP5 7 1.58e-01 -0.308000 4.55e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 1.13e-06 -0.307000 4.85e-05
RND2 GTPase cycle 36 1.44e-03 -0.307000 1.62e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 4.94e-02 0.303000 2.20e-01
Transport of the SLBP independent Mature mRNA 35 1.92e-03 -0.303000 1.94e-02
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.42e-01 -0.302000 5.86e-01
Regulation of IFNA/IFNB signaling 12 7.17e-02 -0.300000 2.75e-01
Cytosolic iron-sulfur cluster assembly 13 6.12e-02 -0.300000 2.52e-01
Metabolism of Angiotensinogen to Angiotensins 12 7.31e-02 0.299000 2.80e-01
Synthesis of pyrophosphates in the cytosol 8 1.44e-01 -0.298000 4.36e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 7.39e-02 -0.298000 2.81e-01
Cation-coupled Chloride cotransporters 6 2.07e-01 -0.297000 5.40e-01
Fructose catabolism 5 2.51e-01 0.297000 6.03e-01
Signaling by activated point mutants of FGFR1 5 2.52e-01 0.296000 6.03e-01
Attachment and Entry 9694614 15 4.78e-02 -0.295000 2.13e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.78e-01 0.294000 4.92e-01
Formation of the beta-catenin:TCF transactivating complex 44 7.57e-04 -0.293000 9.80e-03
Regulation of actin dynamics for phagocytic cup formation 124 2.02e-08 -0.292000 1.66e-06
RMTs methylate histone arginines 35 2.86e-03 -0.291000 2.57e-02
Fcgamma receptor (FCGR) dependent phagocytosis 148 1.04e-09 -0.291000 1.12e-07
Adenylate cyclase activating pathway 8 1.55e-01 -0.290000 4.52e-01
Potential therapeutics for SARS 150 8.41e-10 -0.290000 9.53e-08
NFE2L2 regulating tumorigenic genes 11 9.65e-02 -0.289000 3.34e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.85e-01 -0.289000 5.02e-01
Neurotoxicity of clostridium toxins 8 1.57e-01 -0.289000 4.54e-01
Acyl chain remodelling of PG 11 9.73e-02 0.289000 3.35e-01
TRAF6 mediated IRF7 activation 15 5.34e-02 -0.288000 2.31e-01
FCGR3A-mediated phagocytosis 122 4.09e-08 -0.288000 2.63e-06
Leishmania phagocytosis 122 4.09e-08 -0.288000 2.63e-06
Parasite infection 122 4.09e-08 -0.288000 2.63e-06
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.36e-01 -0.287000 4.23e-01
Interleukin receptor SHC signaling 23 1.76e-02 -0.286000 1.07e-01
SUMO E3 ligases SUMOylate target proteins 161 4.28e-10 -0.285000 5.16e-08
RIP-mediated NFkB activation via ZBP1 17 4.20e-02 -0.285000 1.94e-01
RSV-host interactions 78 1.39e-05 -0.285000 4.47e-04
Alternative complement activation 5 2.72e-01 -0.284000 6.26e-01
EPH-ephrin mediated repulsion of cells 43 1.30e-03 -0.283000 1.51e-02
Interleukin-2 family signaling 38 2.58e-03 -0.282000 2.40e-02
SUMOylation of chromatin organization proteins 57 2.27e-04 -0.282000 4.21e-03
Defective binding of VWF variant to GPIb:IX:V 6 2.31e-01 0.282000 5.68e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 6 2.31e-01 0.282000 5.68e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 2.56e-02 -0.281000 1.40e-01
Cohesin Loading onto Chromatin 10 1.24e-01 -0.281000 3.95e-01
Synthesis of Dolichyl-phosphate 6 2.34e-01 -0.281000 5.72e-01
SUMOylation 167 4.02e-10 -0.280000 5.16e-08
LTC4-CYSLTR mediated IL4 production 5 2.78e-01 -0.280000 6.33e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.02e-02 -0.280000 2.73e-01
Wax and plasmalogen biosynthesis 5 2.80e-01 0.279000 6.34e-01
IRAK1 recruits IKK complex 14 7.15e-02 0.278000 2.75e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 7.15e-02 0.278000 2.75e-01
Signaling by TGFBR3 39 2.69e-03 -0.278000 2.49e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.65e-03 -0.277000 1.80e-02
Heme biosynthesis 13 8.41e-02 -0.277000 3.07e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 2.83e-02 -0.276000 1.51e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 4.08e-06 -0.276000 1.54e-04
NS1 Mediated Effects on Host Pathways 40 2.55e-03 -0.276000 2.39e-02
Malate-aspartate shuttle 8 1.77e-01 -0.276000 4.92e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 1.58e-03 -0.275000 1.76e-02
Lagging Strand Synthesis 20 3.39e-02 -0.274000 1.71e-01
Interferon alpha/beta signaling 64 1.50e-04 -0.274000 3.14e-03
VLDLR internalisation and degradation 15 6.63e-02 -0.274000 2.64e-01
SUMOylation of DNA damage response and repair proteins 77 3.34e-05 -0.273000 8.69e-04
PCNA-Dependent Long Patch Base Excision Repair 21 3.03e-02 -0.273000 1.59e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 2.91e-01 0.273000 6.45e-01
IkBA variant leads to EDA-ID 7 2.13e-01 -0.272000 5.46e-01
Activation of gene expression by SREBF (SREBP) 42 2.33e-03 -0.271000 2.24e-02
Keratan sulfate biosynthesis 20 3.57e-02 -0.271000 1.77e-01
Plasma lipoprotein clearance 32 8.01e-03 -0.271000 5.74e-02
Biotin transport and metabolism 11 1.21e-01 -0.270000 3.91e-01
LGI-ADAM interactions 9 1.62e-01 -0.269000 4.65e-01
Surfactant metabolism 20 3.75e-02 0.269000 1.81e-01
Molybdenum cofactor biosynthesis 6 2.55e-01 -0.268000 6.06e-01
Chromatin modifying enzymes 214 1.33e-11 -0.268000 2.57e-09
Chromatin organization 214 1.33e-11 -0.268000 2.57e-09
Regulation of Complement cascade 97 4.99e-06 -0.268000 1.81e-04
Organic anion transporters 7 2.19e-01 -0.268000 5.54e-01
Regulation of signaling by CBL 22 2.98e-02 -0.268000 1.57e-01
Respiratory syncytial virus (RSV) attachment and entry 19 4.35e-02 -0.267000 1.99e-01
PKMTs methylate histone lysines 43 2.48e-03 -0.267000 2.34e-02
Heme signaling 45 1.99e-03 -0.266000 2.01e-02
Activation of ATR in response to replication stress 37 5.05e-03 -0.266000 3.94e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.84e-03 -0.266000 2.57e-02
OAS antiviral response 8 1.92e-01 -0.266000 5.16e-01
NRAGE signals death through JNK 52 9.07e-04 -0.266000 1.14e-02
FCERI mediated MAPK activation 94 8.84e-06 -0.265000 2.94e-04
Polymerase switching on the C-strand of the telomere 26 1.93e-02 -0.265000 1.14e-01
Trafficking of GluR2-containing AMPA receptors 11 1.29e-01 -0.265000 4.08e-01
Complement cascade 101 4.34e-06 -0.264000 1.61e-04
Apoptotic cleavage of cell adhesion proteins 8 1.97e-01 0.264000 5.24e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 8.81e-02 -0.263000 3.17e-01
Nephron development 5 3.09e-01 -0.263000 6.64e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 1.50e-01 -0.263000 4.42e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 1.65e-03 -0.262000 1.80e-02
Formation of WDR5-containing histone-modifying complexes 42 3.47e-03 -0.261000 2.96e-02
Regulation of signaling by NODAL 6 2.69e-01 0.261000 6.21e-01
Nuclear Envelope Breakdown 53 1.03e-03 -0.261000 1.27e-02
HDL assembly 6 2.70e-01 -0.260000 6.23e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.19e-01 -0.260000 3.88e-01
Thyroxine biosynthesis 5 3.17e-01 0.258000 6.71e-01
Defective factor IX causes hemophilia B 6 2.74e-01 0.258000 6.28e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.74e-01 -0.258000 6.28e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 2.07e-01 -0.258000 5.40e-01
Translation of Structural Proteins 9683701 29 1.64e-02 -0.257000 1.01e-01
Cytoprotection by HMOX1 53 1.21e-03 -0.257000 1.42e-02
Propionyl-CoA catabolism 5 3.22e-01 -0.256000 6.79e-01
DNA Damage Reversal 8 2.10e-01 -0.256000 5.45e-01
Adipogenesis 95 1.84e-05 -0.254000 5.39e-04
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 3.25e-01 -0.254000 6.83e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.14e-01 -0.254000 5.46e-01
Transport of nucleotide sugars 9 1.87e-01 0.254000 5.05e-01
Formation of Fibrin Clot (Clotting Cascade) 26 2.53e-02 0.253000 1.39e-01
RHOV GTPase cycle 36 8.56e-03 -0.253000 6.06e-02
MET activates PTK2 signaling 23 3.58e-02 0.253000 1.77e-01
Phosphate bond hydrolysis by NUDT proteins 7 2.47e-01 0.253000 5.95e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.84e-01 0.252000 6.37e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.21e-03 -0.252000 1.42e-02
WNT mediated activation of DVL 8 2.17e-01 -0.252000 5.50e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 3.67e-02 -0.252000 1.79e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 3.67e-02 -0.252000 1.79e-01
Generation of second messenger molecules 38 7.30e-03 -0.251000 5.29e-02
CD28 dependent PI3K/Akt signaling 22 4.12e-02 -0.251000 1.92e-01
Anti-inflammatory response favouring Leishmania parasite infection 133 5.69e-07 -0.251000 2.68e-05
Leishmania parasite growth and survival 133 5.69e-07 -0.251000 2.68e-05
Respiratory Syncytial Virus Infection Pathway 99 1.62e-05 -0.251000 5.02e-04
Cellular response to heat stress 94 2.71e-05 -0.250000 7.36e-04
Negative regulation of FLT3 15 9.32e-02 -0.250000 3.28e-01
Post-transcriptional silencing by small RNAs 7 2.53e-01 -0.250000 6.04e-01
Regulation of lipid metabolism by PPARalpha 107 8.58e-06 -0.249000 2.94e-04
STING mediated induction of host immune responses 15 9.51e-02 -0.249000 3.30e-01
IL-6-type cytokine receptor ligand interactions 13 1.22e-01 0.248000 3.93e-01
Neurofascin interactions 5 3.38e-01 0.247000 6.95e-01
Signaling by Erythropoietin 24 3.61e-02 -0.247000 1.78e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 7.79e-02 -0.247000 2.90e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 7.79e-02 -0.247000 2.90e-01
Release of apoptotic factors from the mitochondria 6 2.97e-01 -0.246000 6.53e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 3.12e-04 -0.246000 5.32e-03
Signaling by FLT3 fusion proteins 18 7.17e-02 -0.245000 2.75e-01
Dissolution of Fibrin Clot 12 1.45e-01 0.243000 4.36e-01
Metabolism of non-coding RNA 53 2.22e-03 -0.243000 2.19e-02
snRNP Assembly 53 2.22e-03 -0.243000 2.19e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 3.04e-01 -0.243000 6.60e-01
Glyoxylate metabolism and glycine degradation 13 1.31e-01 -0.242000 4.12e-01
AURKA Activation by TPX2 72 3.85e-04 -0.242000 5.91e-03
FOXO-mediated transcription of cell death genes 16 9.47e-02 -0.241000 3.30e-01
Calcitonin-like ligand receptors 5 3.50e-01 -0.241000 7.09e-01
PECAM1 interactions 12 1.48e-01 -0.241000 4.39e-01
Incretin synthesis, secretion, and inactivation 14 1.19e-01 0.241000 3.88e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.19e-01 0.241000 3.88e-01
Regulation of RUNX1 Expression and Activity 18 7.70e-02 -0.241000 2.88e-01
Transcriptional regulation of white adipocyte differentiation 77 2.60e-04 -0.241000 4.68e-03
Arachidonate metabolism 47 4.30e-03 0.241000 3.53e-02
PPARA activates gene expression 105 2.11e-05 -0.240000 5.89e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 2.84e-02 -0.239000 1.51e-01
SUMOylation of DNA methylation proteins 16 9.76e-02 -0.239000 3.35e-01
Base Excision Repair 57 1.81e-03 -0.239000 1.86e-02
Notch-HLH transcription pathway 28 2.88e-02 -0.239000 1.53e-01
Establishment of Sister Chromatid Cohesion 11 1.70e-01 -0.239000 4.77e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 3.56e-01 -0.238000 7.14e-01
Reversal of alkylation damage by DNA dioxygenases 7 2.75e-01 -0.238000 6.28e-01
Zinc influx into cells by the SLC39 gene family 9 2.16e-01 -0.238000 5.50e-01
PDH complex synthesizes acetyl-CoA from PYR 5 3.57e-01 0.238000 7.16e-01
Telomere Maintenance 78 3.29e-04 -0.235000 5.49e-03
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 5.79e-03 -0.235000 4.36e-02
Erythrocytes take up oxygen and release carbon dioxide 7 2.82e-01 -0.235000 6.35e-01
Basigin interactions 21 6.29e-02 -0.234000 2.56e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.61e-01 0.234000 4.63e-01
Diseases associated with glycosylation precursor biosynthesis 15 1.18e-01 -0.233000 3.88e-01
MET activates PI3K/AKT signaling 5 3.69e-01 0.232000 7.24e-01
SUMOylation of RNA binding proteins 47 6.43e-03 -0.230000 4.73e-02
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 1.88e-01 0.229000 5.05e-01
ZBP1(DAI) mediated induction of type I IFNs 20 7.57e-02 -0.229000 2.86e-01
STAT5 Activation 7 2.94e-01 -0.229000 6.50e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 4.34e-02 0.229000 1.99e-01
Metabolism of porphyrins 22 6.40e-02 -0.228000 2.59e-01
Transport of Mature Transcript to Cytoplasm 81 4.08e-04 -0.227000 6.14e-03
Regulation of CDH11 Expression and Function 22 6.52e-02 -0.227000 2.61e-01
Maturation of spike protein 9694548 36 1.87e-02 -0.226000 1.13e-01
RHOB GTPase cycle 64 1.80e-03 -0.226000 1.86e-02
CDH11 homotypic and heterotypic interactions 5 3.82e-01 -0.226000 7.37e-01
DNA Double Strand Break Response 47 7.75e-03 -0.224000 5.59e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 1.97e-01 -0.224000 5.24e-01
Defective EXT2 causes exostoses 2 11 1.97e-01 -0.224000 5.24e-01
HDACs deacetylate histones 45 9.33e-03 -0.224000 6.46e-02
Activation of the TFAP2 (AP-2) family of transcription factors 7 3.05e-01 -0.224000 6.60e-01
Mitochondrial tRNA aminoacylation 21 7.61e-02 -0.224000 2.87e-01
CRMPs in Sema3A signaling 14 1.48e-01 -0.224000 4.39e-01
Anchoring fibril formation 8 2.74e-01 0.223000 6.28e-01
Response of Mtb to phagocytosis 22 7.16e-02 -0.222000 2.75e-01
Transcriptional activation of mitochondrial biogenesis 52 5.66e-03 -0.222000 4.28e-02
Acyl chain remodelling of PS 14 1.52e-01 0.221000 4.47e-01
Regulation of HSF1-mediated heat shock response 79 6.92e-04 -0.221000 9.07e-03
Reduction of cytosolic Ca++ levels 9 2.51e-01 -0.221000 6.03e-01
Effects of PIP2 hydrolysis 24 6.13e-02 -0.221000 2.52e-01
Metabolic disorders of biological oxidation enzymes 23 6.83e-02 0.220000 2.70e-01
tRNA processing in the nucleus 59 3.68e-03 -0.219000 3.11e-02
Cell death signalling via NRAGE, NRIF and NADE 69 1.73e-03 -0.218000 1.84e-02
Loss of Nlp from mitotic centrosomes 69 1.74e-03 -0.218000 1.84e-02
Loss of proteins required for interphase microtubule organization from the centrosome 69 1.74e-03 -0.218000 1.84e-02
Phase 4 - resting membrane potential 9 2.58e-01 -0.218000 6.10e-01
RUNX3 regulates p14-ARF 10 2.33e-01 -0.218000 5.71e-01
MET promotes cell motility 34 2.83e-02 0.217000 1.51e-01
Sema3A PAK dependent Axon repulsion 16 1.34e-01 -0.216000 4.21e-01
Synthesis of PE 12 1.96e-01 0.216000 5.23e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.05e-01 -0.215000 7.62e-01
Dermatan sulfate biosynthesis 6 3.61e-01 0.215000 7.20e-01
RHOC GTPase cycle 71 1.73e-03 -0.215000 1.84e-02
ISG15 antiviral mechanism 72 1.63e-03 -0.215000 1.80e-02
Inositol phosphate metabolism 42 1.64e-02 -0.214000 1.01e-01
Zinc transporters 12 1.99e-01 -0.214000 5.27e-01
GDP-fucose biosynthesis 6 3.65e-01 -0.214000 7.23e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 3.28e-01 0.214000 6.86e-01
TNFR1-mediated ceramide production 6 3.65e-01 -0.213000 7.23e-01
Laminin interactions 26 6.01e-02 0.213000 2.49e-01
DNA Double-Strand Break Repair 137 1.72e-05 -0.213000 5.22e-04
Apoptosis induced DNA fragmentation 10 2.45e-01 0.212000 5.92e-01
Adenylate cyclase inhibitory pathway 11 2.24e-01 -0.212000 5.60e-01
Inactivation of CDC42 and RAC1 7 3.33e-01 0.211000 6.87e-01
p130Cas linkage to MAPK signaling for integrins 11 2.26e-01 0.211000 5.61e-01
Alpha-oxidation of phytanate 6 3.71e-01 0.211000 7.24e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 1.44e-01 0.211000 4.36e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.80e-02 -0.211000 2.42e-01
Glucagon-type ligand receptors 20 1.03e-01 -0.211000 3.48e-01
Xenobiotics 12 2.08e-01 -0.210000 5.40e-01
Signaling by ALK fusions and activated point mutants 89 6.35e-04 -0.209000 8.61e-03
Signaling by ALK in cancer 89 6.35e-04 -0.209000 8.61e-03
Regulation of Expression and Function of Type II Classical Cadherins 24 7.64e-02 -0.209000 2.87e-01
Regulation of Homotypic Cell-Cell Adhesion 24 7.64e-02 -0.209000 2.87e-01
Purine ribonucleoside monophosphate biosynthesis 9 2.79e-01 -0.209000 6.33e-01
Signaling by Retinoic Acid 29 5.19e-02 -0.209000 2.27e-01
DAP12 signaling 28 5.62e-02 -0.209000 2.38e-01
Triglyceride biosynthesis 9 2.79e-01 0.208000 6.33e-01
HS-GAG biosynthesis 21 9.88e-02 -0.208000 3.37e-01
SLC transporter disorders 76 1.74e-03 -0.208000 1.84e-02
Transcriptional regulation by small RNAs 61 5.05e-03 -0.208000 3.94e-02
Regulation of CDH11 function 9 2.83e-01 -0.207000 6.35e-01
Prostanoid ligand receptors 8 3.13e-01 0.206000 6.69e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 1.99e-01 -0.206000 5.27e-01
Toxicity of botulinum toxin type D (botD) 5 4.26e-01 -0.206000 7.77e-01
Toxicity of botulinum toxin type F (botF) 5 4.26e-01 -0.206000 7.77e-01
Centrosome maturation 81 1.38e-03 -0.206000 1.57e-02
Recruitment of mitotic centrosome proteins and complexes 81 1.38e-03 -0.206000 1.57e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 2.86e-01 -0.206000 6.39e-01
FLT3 signaling in disease 27 6.47e-02 -0.205000 2.60e-01
DNA Repair 289 1.99e-09 -0.205000 1.92e-07
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 5.30e-02 -0.204000 2.30e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 1.24e-01 -0.204000 3.95e-01
Chromosome Maintenance 103 3.49e-04 -0.204000 5.61e-03
Host Interactions of HIV factors 118 1.39e-04 -0.203000 2.98e-03
Intrinsic Pathway of Fibrin Clot Formation 15 1.74e-01 0.203000 4.85e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.00e-01 0.203000 3.40e-01
Acyl chain remodelling of PE 20 1.19e-01 0.201000 3.88e-01
Aspartate and asparagine metabolism 9 2.96e-01 0.201000 6.52e-01
Regulation of MITF-M-dependent genes involved in pigmentation 38 3.21e-02 -0.201000 1.65e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.49e-01 -0.201000 6.00e-01
CD209 (DC-SIGN) signaling 20 1.21e-01 -0.200000 3.91e-01
Cell surface interactions at the vascular wall 173 5.98e-06 -0.199000 2.13e-04
Early Phase of HIV Life Cycle 14 1.96e-01 -0.199000 5.23e-01
Circadian Clock 67 4.76e-03 -0.199000 3.77e-02
Displacement of DNA glycosylase by APEX1 9 3.00e-01 -0.199000 6.58e-01
RHOA GTPase cycle 138 5.48e-05 -0.199000 1.35e-03
Sphingolipid catabolism 11 2.54e-01 0.199000 6.05e-01
mRNA Splicing - Minor Pathway 50 1.51e-02 -0.199000 9.77e-02
Synaptic adhesion-like molecules 17 1.57e-01 -0.198000 4.54e-01
Maturation of nucleoprotein 9683610 11 2.55e-01 -0.198000 6.06e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 188 2.86e-06 -0.198000 1.10e-04
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 51 1.47e-02 -0.197000 9.60e-02
NGF-stimulated transcription 32 5.35e-02 0.197000 2.31e-01
Metabolism of amine-derived hormones 10 2.80e-01 0.197000 6.34e-01
Regulation of PTEN localization 9 3.06e-01 0.197000 6.60e-01
HIV Life Cycle 144 4.66e-05 -0.197000 1.18e-03
Phospholipase C-mediated cascade: FGFR1 8 3.37e-01 0.196000 6.93e-01
Gluconeogenesis 19 1.39e-01 -0.196000 4.30e-01
RUNX1 regulates estrogen receptor mediated transcription 6 4.06e-01 -0.196000 7.62e-01
Inwardly rectifying K+ channels 23 1.04e-01 0.196000 3.51e-01
p75 NTR receptor-mediated signalling 89 1.44e-03 -0.195000 1.62e-02
Late Phase of HIV Life Cycle 131 1.13e-04 -0.195000 2.54e-03
Common Pathway of Fibrin Clot Formation 13 2.23e-01 0.195000 5.59e-01
RHO GTPases activate CIT 18 1.53e-01 -0.194000 4.49e-01
LDL clearance 17 1.67e-01 -0.194000 4.73e-01
Signaling by Hippo 18 1.56e-01 0.193000 4.53e-01
SARS-CoV-1 activates/modulates innate immune responses 40 3.46e-02 -0.193000 1.73e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 1.35e-02 -0.193000 8.85e-02
Mitochondrial unfolded protein response (UPRmt) 17 1.70e-01 -0.192000 4.76e-01
SUMOylation of transcription cofactors 44 2.75e-02 -0.192000 1.49e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 9.66e-02 -0.192000 3.34e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 5.89e-04 -0.191000 8.35e-03
Homology Directed Repair 110 5.30e-04 -0.191000 7.56e-03
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 3.82e-01 -0.191000 7.37e-01
PI3K/AKT activation 8 3.50e-01 0.191000 7.09e-01
Regulation of innate immune responses to cytosolic DNA 14 2.17e-01 -0.191000 5.50e-01
Regulation of PTEN gene transcription 59 1.14e-02 -0.191000 7.65e-02
NPAS4 regulates expression of target genes 16 1.87e-01 0.190000 5.05e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.64e-01 -0.190000 4.68e-01
Regulation of PLK1 Activity at G2/M Transition 87 2.25e-03 -0.190000 2.20e-02
SARS-CoV Infections 434 1.33e-11 -0.189000 2.57e-09
SLC15A4:TASL-dependent IRF5 activation 6 4.24e-01 -0.189000 7.77e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 3.05e-02 -0.189000 1.59e-01
Non-integrin membrane-ECM interactions 49 2.27e-02 0.188000 1.28e-01
Glucose metabolism 76 4.63e-03 -0.188000 3.75e-02
RNA Polymerase I Promoter Opening 17 1.81e-01 0.188000 4.96e-01
Signaling by PDGFR in disease 19 1.57e-01 -0.187000 4.54e-01
Costimulation by the CD28 family 74 5.41e-03 -0.187000 4.12e-02
Organic cation transport 8 3.60e-01 0.187000 7.19e-01
Organic cation/anion/zwitterion transport 8 3.60e-01 0.187000 7.19e-01
Formation of RNA Pol II elongation complex 56 1.55e-02 -0.187000 9.93e-02
RNA Polymerase II Transcription Elongation 56 1.55e-02 -0.187000 9.93e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 2.63e-01 0.187000 6.16e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 2.84e-01 -0.187000 6.36e-01
The phototransduction cascade 27 9.40e-02 0.186000 3.29e-01
PKA activation in glucagon signalling 14 2.28e-01 -0.186000 5.65e-01
Translation of Structural Proteins 9694635 56 1.62e-02 -0.186000 1.01e-01
tRNA Aminoacylation 42 3.76e-02 -0.185000 1.81e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.33e-02 -0.185000 1.68e-01
Regulation of endogenous retroelements 93 2.01e-03 -0.185000 2.01e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.82e-02 -0.185000 1.82e-01
HIV Transcription Elongation 42 3.82e-02 -0.185000 1.82e-01
Tat-mediated elongation of the HIV-1 transcript 42 3.82e-02 -0.185000 1.82e-01
Neurotransmitter clearance 5 4.75e-01 0.185000 8.17e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.14e-07 -0.184000 6.09e-06
PINK1-PRKN Mediated Mitophagy 31 7.56e-02 0.184000 2.86e-01
Sensory processing of sound 58 1.56e-02 -0.184000 9.93e-02
DNA replication initiation 8 3.69e-01 -0.183000 7.24e-01
mRNA Editing 8 3.70e-01 -0.183000 7.24e-01
Receptor-type tyrosine-protein phosphatases 11 2.94e-01 0.183000 6.50e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.16e-02 -0.182000 2.27e-01
RHOU GTPase cycle 40 4.62e-02 -0.182000 2.08e-01
Axonal growth inhibition (RHOA activation) 7 4.05e-01 0.182000 7.62e-01
p75NTR regulates axonogenesis 7 4.05e-01 0.182000 7.62e-01
Ion transport by P-type ATPases 44 3.71e-02 -0.182000 1.80e-01
Platelet calcium homeostasis 22 1.40e-01 -0.182000 4.32e-01
RHOT1 GTPase cycle 5 4.82e-01 0.181000 8.24e-01
Synthesis of PIPs at the Golgi membrane 16 2.10e-01 -0.181000 5.45e-01
mRNA Splicing - Major Pathway 203 8.71e-06 -0.181000 2.94e-04
SIRT1 negatively regulates rRNA expression 22 1.42e-01 0.181000 4.34e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 2.87e-03 -0.181000 2.57e-02
Amplification of signal from the kinetochores 91 2.87e-03 -0.181000 2.57e-02
Vitamin B2 (riboflavin) metabolism 6 4.43e-01 -0.181000 7.94e-01
Glycosphingolipid catabolism 31 8.23e-02 0.180000 3.02e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.50e-02 -0.180000 9.71e-02
Sperm Motility And Taxes 6 4.45e-01 -0.180000 7.94e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 4.86e-01 -0.180000 8.29e-01
FLT3 Signaling 38 5.50e-02 -0.180000 2.35e-01
Sodium/Calcium exchangers 9 3.50e-01 0.180000 7.09e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 4.11e-01 0.179000 7.67e-01
Late endosomal microautophagy 30 8.98e-02 -0.179000 3.20e-01
Signaling by the B Cell Receptor (BCR) 151 1.52e-04 -0.179000 3.15e-03
Synthesis of IP3 and IP4 in the cytosol 22 1.47e-01 -0.178000 4.39e-01
Defects in biotin (Btn) metabolism 8 3.82e-01 -0.178000 7.37e-01
Alpha-protein kinase 1 signaling pathway 11 3.06e-01 0.178000 6.60e-01
Interferon Signaling 240 2.04e-06 -0.178000 8.19e-05
Signaling by NOTCH1 66 1.24e-02 -0.178000 8.30e-02
FGFR2b ligand binding and activation 6 4.51e-01 -0.178000 7.99e-01
Vitamin B5 (pantothenate) metabolism 20 1.70e-01 -0.177000 4.76e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 2.20e-01 0.177000 5.54e-01
Resolution of D-Loop Structures 35 6.99e-02 -0.177000 2.73e-01
Purine salvage 12 2.88e-01 -0.177000 6.43e-01
MET activates RAP1 and RAC1 10 3.33e-01 0.177000 6.87e-01
Glycolysis 68 1.17e-02 -0.177000 7.82e-02
Regulation of TP53 Activity 153 1.60e-04 -0.177000 3.24e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 1.52e-01 -0.177000 4.46e-01
Infection with Mycobacterium tuberculosis 26 1.19e-01 -0.176000 3.88e-01
HIV Infection 213 9.22e-06 -0.176000 3.01e-04
Role of second messengers in netrin-1 signaling 6 4.56e-01 -0.176000 8.06e-01
Termination of O-glycan biosynthesis 16 2.24e-01 -0.176000 5.60e-01
Activation of BAD and translocation to mitochondria 15 2.39e-01 0.175000 5.81e-01
Dopamine Neurotransmitter Release Cycle 18 1.98e-01 -0.175000 5.24e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 4.04e-03 -0.175000 3.37e-02
FGFR2c ligand binding and activation 5 4.98e-01 0.175000 8.35e-01
G alpha (12/13) signalling events 68 1.26e-02 -0.175000 8.39e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 4.25e-01 -0.174000 7.77e-01
HCMV Late Events 67 1.40e-02 -0.174000 9.12e-02
SHC-related events triggered by IGF1R 7 4.26e-01 -0.174000 7.77e-01
Signaling by FGFR2 IIIa TM 18 2.03e-01 -0.173000 5.33e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.19e-01 -0.173000 3.88e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.98e-01 -0.173000 6.55e-01
Antiviral mechanism by IFN-stimulated genes 140 4.28e-04 -0.172000 6.35e-03
Diseases associated with surfactant metabolism 5 5.05e-01 0.172000 8.35e-01
Biosynthesis of maresins 6 4.66e-01 -0.172000 8.13e-01
Mitotic Prometaphase 193 3.91e-05 -0.172000 1.00e-03
2-LTR circle formation 7 4.32e-01 -0.172000 7.83e-01
FCERI mediated NF-kB activation 130 7.27e-04 -0.172000 9.47e-03
mRNA Splicing 211 1.73e-05 -0.172000 5.22e-04
Ion homeostasis 42 5.45e-02 -0.171000 2.34e-01
Diseases of DNA repair 51 3.46e-02 -0.171000 1.73e-01
Transport to the Golgi and subsequent modification 171 1.15e-04 -0.171000 2.55e-03
Rab regulation of trafficking 121 1.17e-03 -0.171000 1.40e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 34 8.51e-02 -0.171000 3.08e-01
Leishmania infection 213 1.87e-05 -0.170000 5.39e-04
Parasitic Infection Pathways 213 1.87e-05 -0.170000 5.39e-04
ALK mutants bind TKIs 11 3.29e-01 -0.170000 6.86e-01
RHO GTPases activate KTN1 11 3.29e-01 -0.170000 6.86e-01
HDR through Single Strand Annealing (SSA) 37 7.38e-02 -0.170000 2.81e-01
Association of TriC/CCT with target proteins during biosynthesis 35 8.22e-02 -0.170000 3.02e-01
Sensory processing of sound by inner hair cells of the cochlea 54 3.11e-02 -0.170000 1.62e-01
Specification of primordial germ cells 6 4.73e-01 0.169000 8.15e-01
Plasma lipoprotein assembly 10 3.54e-01 -0.169000 7.13e-01
DNA Damage Recognition in GG-NER 38 7.14e-02 -0.169000 2.75e-01
Metabolism of steroid hormones 21 1.81e-01 0.169000 4.96e-01
Cell Cycle, Mitotic 488 1.70e-10 -0.169000 2.52e-08
Kinesins 51 3.76e-02 -0.168000 1.81e-01
Cell Cycle 611 1.33e-12 -0.168000 3.67e-10
Factors involved in megakaryocyte development and platelet production 129 1.04e-03 -0.167000 1.27e-02
Reactions specific to the complex N-glycan synthesis pathway 7 4.44e-01 -0.167000 7.94e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 1.06e-02 -0.166000 7.26e-02
Cytosolic sensors of pathogen-associated DNA 63 2.25e-02 -0.166000 1.28e-01
PI-3K cascade:FGFR1 13 3.00e-01 0.166000 6.57e-01
Formation of the Early Elongation Complex 33 9.86e-02 -0.166000 3.36e-01
Formation of the HIV-1 Early Elongation Complex 33 9.86e-02 -0.166000 3.36e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 1.35e-01 -0.166000 4.22e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.35e-01 -0.166000 4.22e-01
CS/DS degradation 9 3.89e-01 0.166000 7.46e-01
Interleukin-1 processing 8 4.17e-01 -0.166000 7.70e-01
Maturation of nucleoprotein 9694631 15 2.67e-01 -0.166000 6.19e-01
Signaling by NODAL 15 2.67e-01 0.165000 6.19e-01
Impaired BRCA2 binding to RAD51 35 9.02e-02 -0.165000 3.21e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 3.90e-01 -0.165000 7.46e-01
Regulation of TP53 Activity through Methylation 19 2.12e-01 -0.165000 5.46e-01
Cellular response to mitochondrial stress 9 3.90e-01 0.165000 7.46e-01
G alpha (s) signalling events 96 5.12e-03 -0.165000 3.98e-02
IRF3-mediated induction of type I IFN 12 3.23e-01 -0.165000 6.80e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 2.89e-01 -0.164000 6.43e-01
GPVI-mediated activation cascade 32 1.09e-01 -0.164000 3.65e-01
Assembly of the ORC complex at the origin of replication 23 1.75e-01 0.163000 4.88e-01
Synthesis of PIPs at the ER membrane 5 5.27e-01 -0.163000 8.36e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.02e-02 -0.163000 3.21e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 2.91e-01 -0.163000 6.45e-01
RUNX2 regulates genes involved in cell migration 6 4.91e-01 -0.163000 8.33e-01
ECM proteoglycans 47 5.42e-02 0.162000 2.33e-01
DAP12 interactions 39 7.98e-02 -0.162000 2.95e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.53e-01 -0.162000 4.49e-01
HCMV Infection 106 4.07e-03 -0.161000 3.38e-02
CDC42 GTPase cycle 140 9.99e-04 -0.161000 1.25e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 2.13e-01 -0.161000 5.46e-01
Trafficking of AMPA receptors 20 2.13e-01 -0.161000 5.46e-01
Activation of the phototransduction cascade 9 4.04e-01 0.161000 7.62e-01
DAG and IP3 signaling 34 1.05e-01 -0.161000 3.54e-01
Late SARS-CoV-2 Infection Events 64 2.67e-02 -0.160000 1.46e-01
Synthesis, secretion, and deacylation of Ghrelin 11 3.59e-01 0.160000 7.18e-01
Recruitment of NuMA to mitotic centrosomes 88 9.56e-03 -0.160000 6.58e-02
TCF dependent signaling in response to WNT 152 6.72e-04 -0.160000 8.93e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 4.88e-03 -0.160000 3.84e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.67e-01 -0.160000 4.73e-01
Fanconi Anemia Pathway 36 9.77e-02 -0.159000 3.35e-01
RHO GTPases Activate NADPH Oxidases 22 1.96e-01 0.159000 5.23e-01
MicroRNA (miRNA) biogenesis 24 1.77e-01 -0.159000 4.92e-01
COPI-mediated anterograde transport 92 8.45e-03 -0.159000 6.01e-02
PERK regulates gene expression 31 1.28e-01 0.158000 4.06e-01
STAT5 activation downstream of FLT3 ITD mutants 9 4.12e-01 -0.158000 7.67e-01
Transcriptional Regulation by MECP2 49 5.57e-02 -0.158000 2.38e-01
Negative feedback regulation of MAPK pathway 6 5.03e-01 0.158000 8.35e-01
PI5P Regulates TP53 Acetylation 8 4.42e-01 -0.157000 7.92e-01
RNA Polymerase I Transcription Initiation 47 6.29e-02 -0.157000 2.56e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 3.91e-01 -0.157000 7.46e-01
ERBB2 Regulates Cell Motility 10 3.91e-01 0.157000 7.46e-01
AKT phosphorylates targets in the cytosol 14 3.12e-01 -0.156000 6.67e-01
Dectin-2 family 19 2.39e-01 0.156000 5.81e-01
Nitric oxide stimulates guanylate cyclase 15 2.96e-01 -0.156000 6.52e-01
Viral Infection Pathways 775 1.52e-13 -0.156000 4.87e-11
Regulation of PTEN mRNA translation 13 3.31e-01 -0.156000 6.87e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.47e-01 -0.156000 4.39e-01
Role of ABL in ROBO-SLIT signaling 6 5.10e-01 -0.155000 8.35e-01
Interleukin-6 signaling 11 3.73e-01 -0.155000 7.24e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 5.13e-01 -0.154000 8.36e-01
Elevation of cytosolic Ca2+ levels 13 3.36e-01 -0.154000 6.92e-01
Downstream signal transduction 27 1.66e-01 -0.154000 4.71e-01
Pregnenolone biosynthesis 10 3.99e-01 -0.154000 7.57e-01
Constitutive Signaling by Overexpressed ERBB2 11 3.77e-01 -0.154000 7.31e-01
Glutathione conjugation 27 1.67e-01 0.154000 4.73e-01
PI3K events in ERBB4 signaling 6 5.15e-01 0.153000 8.36e-01
Resolution of Sister Chromatid Cohesion 116 4.30e-03 -0.153000 3.53e-02
RNA Polymerase II Transcription Termination 66 3.11e-02 -0.153000 1.62e-01
Serine biosynthesis 8 4.52e-01 0.153000 8.01e-01
Anchoring of the basal body to the plasma membrane 97 9.02e-03 -0.153000 6.29e-02
Vesicle-mediated transport 665 1.50e-11 -0.153000 2.64e-09
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 2.74e-01 -0.153000 6.28e-01
Epigenetic regulation of gene expression 264 1.92e-05 -0.153000 5.43e-04
Nuclear Receptor transcription pathway 38 1.04e-01 -0.153000 3.51e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 3.95e-02 -0.152000 1.86e-01
G1/S Transition 120 3.98e-03 -0.152000 3.35e-02
CD28 co-stimulation 33 1.30e-01 -0.152000 4.12e-01
Formation of axial mesoderm 6 5.19e-01 -0.152000 8.36e-01
Heme degradation 10 4.06e-01 -0.152000 7.62e-01
Death Receptor Signaling 145 1.62e-03 -0.152000 1.80e-02
RHO GTPases Activate Formins 128 3.08e-03 -0.151000 2.70e-02
FLT3 signaling through SRC family kinases 6 5.21e-01 -0.151000 8.36e-01
Processing of DNA double-strand break ends 69 2.97e-02 -0.151000 1.57e-01
Suppression of phagosomal maturation 12 3.64e-01 -0.151000 7.23e-01
Mitotic G1 phase and G1/S transition 138 2.17e-03 -0.151000 2.16e-02
TGFBR3 PTM regulation 10 4.08e-01 -0.151000 7.62e-01
Diseases associated with O-glycosylation of proteins 50 6.55e-02 -0.151000 2.61e-01
Activation of RAC1 11 3.87e-01 0.150000 7.44e-01
CaM pathway 28 1.70e-01 -0.150000 4.76e-01
Calmodulin induced events 28 1.70e-01 -0.150000 4.76e-01
Mitochondrial RNA degradation 25 1.95e-01 0.150000 5.21e-01
Fc epsilon receptor (FCERI) signaling 180 5.24e-04 -0.150000 7.53e-03
FGFR1 ligand binding and activation 10 4.12e-01 0.150000 7.67e-01
Constitutive Signaling by EGFRvIII 14 3.33e-01 -0.150000 6.87e-01
Signaling by EGFRvIII in Cancer 14 3.33e-01 -0.150000 6.87e-01
Cellular hexose transport 15 3.16e-01 -0.150000 6.71e-01
Regulation of KIT signaling 15 3.16e-01 -0.150000 6.71e-01
ER to Golgi Anterograde Transport 145 1.89e-03 -0.149000 1.93e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 191 3.69e-04 -0.149000 5.73e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.71e-02 0.149000 2.11e-01
mRNA 3’-end processing 57 5.14e-02 -0.149000 2.26e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 3.02e-01 0.149000 6.60e-01
Attachment of GPI anchor to uPAR 7 4.96e-01 -0.148000 8.35e-01
Ribosomal scanning and start codon recognition 58 5.13e-02 0.148000 2.26e-01
RUNX3 regulates WNT signaling 8 4.69e-01 -0.148000 8.13e-01
Paracetamol ADME 19 2.66e-01 -0.148000 6.18e-01
Golgi-to-ER retrograde transport 123 4.73e-03 -0.147000 3.77e-02
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.85e-01 -0.147000 5.02e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 4.51e-02 -0.147000 2.04e-01
Interferon gamma signaling 90 1.62e-02 -0.147000 1.01e-01
Signaling by KIT in disease 20 2.58e-01 -0.146000 6.10e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.58e-01 -0.146000 6.10e-01
Defects of platelet adhesion to exposed collagen 7 5.03e-01 0.146000 8.35e-01
EML4 and NUDC in mitotic spindle formation 107 9.06e-03 -0.146000 6.31e-02
RHOBTB2 GTPase cycle 23 2.26e-01 -0.146000 5.61e-01
G-protein mediated events 44 9.40e-02 -0.146000 3.29e-01
Downregulation of ERBB4 signaling 8 4.75e-01 0.146000 8.17e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.08e-01 -0.146000 5.40e-01
Gene Silencing by RNA 87 1.89e-02 -0.146000 1.14e-01
HATs acetylate histones 92 1.61e-02 -0.145000 1.01e-01
SHC-mediated cascade:FGFR1 13 3.66e-01 0.145000 7.23e-01
Hyaluronan metabolism 15 3.32e-01 -0.145000 6.87e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 2.62e-01 0.145000 6.16e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 5.40e-01 0.145000 8.38e-01
Signaling by ERBB2 ECD mutants 15 3.33e-01 -0.144000 6.87e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 5.09e-01 -0.144000 8.35e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.13e-01 -0.144000 5.46e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.13e-01 -0.144000 5.46e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 2.13e-01 -0.144000 5.46e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 2.13e-01 -0.144000 5.46e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 5.44e-01 -0.143000 8.40e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 5.44e-01 -0.143000 8.40e-01
HCMV Early Events 84 2.35e-02 -0.143000 1.31e-01
MyD88 deficiency (TLR2/4) 14 3.55e-01 0.143000 7.14e-01
Signaling by Nuclear Receptors 210 3.67e-04 -0.143000 5.73e-03
Signaling by NTRK3 (TRKC) 15 3.39e-01 -0.143000 6.96e-01
Mitotic Prophase 96 1.61e-02 -0.142000 1.01e-01
The activation of arylsulfatases 10 4.37e-01 0.142000 7.86e-01
DNA Damage Bypass 47 9.33e-02 -0.141000 3.28e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 1.80e-01 -0.141000 4.96e-01
RHOD GTPase cycle 49 8.69e-02 -0.141000 3.14e-01
Translation initiation complex formation 58 6.29e-02 0.141000 2.56e-01
Infectious disease 958 1.47e-13 -0.141000 4.87e-11
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 2.53e-01 0.141000 6.04e-01
TRAF6 mediated NF-kB activation 23 2.44e-01 -0.140000 5.92e-01
Interleukin-18 signaling 6 5.52e-01 0.140000 8.43e-01
Relaxin receptors 5 5.87e-01 0.140000 8.64e-01
Pyroptosis 25 2.26e-01 -0.140000 5.61e-01
Impaired BRCA2 binding to PALB2 24 2.35e-01 -0.140000 5.74e-01
PKA activation 15 3.48e-01 -0.140000 7.07e-01
DNA Damage/Telomere Stress Induced Senescence 42 1.17e-01 -0.140000 3.87e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 4.02e-01 0.140000 7.60e-01
Transport of connexons to the plasma membrane 12 4.02e-01 0.140000 7.60e-01
TRIF-mediated programmed cell death 9 4.68e-01 -0.140000 8.13e-01
Recycling of eIF2:GDP 8 4.94e-01 0.140000 8.33e-01
rRNA modification in the mitochondrion 8 4.94e-01 -0.140000 8.33e-01
Modulation by Mtb of host immune system 7 5.24e-01 0.139000 8.36e-01
Adherens junctions interactions 38 1.39e-01 -0.139000 4.30e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 3.38e-01 -0.138000 6.94e-01
PLC beta mediated events 40 1.30e-01 -0.138000 4.11e-01
Regulation of IFNG signaling 14 3.70e-01 0.138000 7.24e-01
Sodium/Proton exchangers 7 5.29e-01 -0.137000 8.36e-01
Drug ADME 57 7.27e-02 -0.137000 2.78e-01
Pre-NOTCH Expression and Processing 63 5.96e-02 -0.137000 2.48e-01
Glutamate Neurotransmitter Release Cycle 19 3.01e-01 -0.137000 6.59e-01
O-glycosylation of TSR domain-containing proteins 28 2.10e-01 -0.137000 5.45e-01
Gene expression (Transcription) 1404 8.68e-18 -0.137000 1.67e-14
cGMP effects 12 4.14e-01 -0.136000 7.70e-01
Nucleotide salvage 21 2.80e-01 -0.136000 6.34e-01
Platelet Aggregation (Plug Formation) 29 2.05e-01 0.136000 5.36e-01
Hedgehog ‘on’ state 66 5.60e-02 -0.136000 2.38e-01
Advanced glycosylation endproduct receptor signaling 12 4.16e-01 0.136000 7.70e-01
Signaling by SCF-KIT 40 1.38e-01 -0.136000 4.28e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 9.41e-02 0.136000 3.29e-01
GP1b-IX-V activation signalling 11 4.37e-01 0.135000 7.86e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 2.33e-01 0.135000 5.70e-01
MHC class II antigen presentation 113 1.32e-02 -0.135000 8.69e-02
CD163 mediating an anti-inflammatory response 9 4.84e-01 0.135000 8.28e-01
Diseases of hemostasis 14 3.83e-01 0.135000 7.38e-01
Termination of translesion DNA synthesis 32 1.88e-01 -0.134000 5.06e-01
SARS-CoV-2 Infection 267 1.57e-04 -0.134000 3.22e-03
Detoxification of Reactive Oxygen Species 30 2.03e-01 0.134000 5.33e-01
Defective C1GALT1C1 causes TNPS 10 4.62e-01 0.134000 8.13e-01
RNA Polymerase II Transcription 1197 5.02e-15 -0.134000 3.23e-12
Generic Transcription Pathway 1079 9.29e-14 -0.134000 4.47e-11
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.11e-01 0.134000 6.67e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.65e-01 -0.134000 6.18e-01
Fructose metabolism 7 5.40e-01 0.134000 8.38e-01
COPII-mediated vesicle transport 67 5.84e-02 -0.134000 2.44e-01
IRAK4 deficiency (TLR2/4) 15 3.72e-01 0.133000 7.24e-01
Initiation of Nuclear Envelope (NE) Reformation 19 3.15e-01 -0.133000 6.71e-01
HDR through Homologous Recombination (HRR) 68 5.78e-02 -0.133000 2.42e-01
G2/M Transition 177 2.27e-03 -0.133000 2.21e-02
Diseases of Mismatch Repair (MMR) 5 6.07e-01 -0.133000 8.76e-01
Defective GALNT12 causes CRCS1 9 4.91e-01 0.133000 8.33e-01
Signaling by WNT 240 3.98e-04 -0.133000 6.04e-03
Gain-of-function MRAS complexes activate RAF signaling 8 5.16e-01 0.133000 8.36e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 5.16e-01 0.133000 8.36e-01
Signaling by MRAS-complex mutants 8 5.16e-01 0.133000 8.36e-01
Unfolded Protein Response (UPR) 85 3.45e-02 -0.133000 1.73e-01
Transcriptional Regulation by TP53 346 2.22e-05 -0.133000 6.12e-04
Response to metal ions 6 5.74e-01 -0.133000 8.57e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 6.30e-02 -0.132000 2.56e-01
Nectin/Necl trans heterodimerization 5 6.09e-01 -0.132000 8.76e-01
MECP2 regulates transcription factors 5 6.09e-01 0.132000 8.76e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 1.10e-01 -0.132000 3.66e-01
Signaling by MAPK mutants 6 5.76e-01 0.132000 8.57e-01
PKA-mediated phosphorylation of CREB 17 3.46e-01 -0.132000 7.06e-01
Mitochondrial biogenesis 91 2.96e-02 -0.132000 1.57e-01
SUMOylation of transcription factors 16 3.61e-01 -0.132000 7.20e-01
Syndecan interactions 25 2.54e-01 0.132000 6.05e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 5.76e-01 -0.132000 8.57e-01
Glucagon signaling in metabolic regulation 26 2.45e-01 -0.132000 5.92e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.75e-01 -0.132000 6.28e-01
Mitotic G2-G2/M phases 179 2.41e-03 -0.131000 2.29e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 2.40e-02 0.131000 1.33e-01
RUNX3 Regulates Immune Response and Cell Migration 5 6.13e-01 0.131000 8.77e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 1.78e-02 0.131000 1.08e-01
Ca2+ activated K+ channels 6 5.79e-01 0.131000 8.61e-01
Beta-oxidation of pristanoyl-CoA 9 4.98e-01 0.130000 8.35e-01
Nucleotide Excision Repair 108 1.92e-02 -0.130000 1.14e-01
Class B/2 (Secretin family receptors) 57 8.92e-02 -0.130000 3.19e-01
Membrane Trafficking 574 9.83e-08 -0.130000 5.74e-06
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 5.51e-01 0.130000 8.42e-01
MTOR signalling 39 1.62e-01 -0.130000 4.63e-01
G2/M Checkpoints 126 1.24e-02 -0.129000 8.29e-02
Homologous DNA Pairing and Strand Exchange 43 1.44e-01 -0.129000 4.36e-01
Mitotic Spindle Checkpoint 108 2.07e-02 -0.129000 1.21e-01
Sensory processing of sound by outer hair cells of the cochlea 41 1.54e-01 -0.129000 4.49e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 5.05e-01 -0.128000 8.35e-01
Prevention of phagosomal-lysosomal fusion 9 5.05e-01 -0.128000 8.35e-01
S Phase 150 6.78e-03 -0.128000 4.97e-02
Transcription of the HIV genome 67 7.00e-02 -0.128000 2.73e-01
Cytochrome c-mediated apoptotic response 13 4.25e-01 0.128000 7.77e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 5.07e-01 0.128000 8.35e-01
Transcriptional regulation of granulopoiesis 44 1.42e-01 -0.128000 4.35e-01
Ovarian tumor domain proteases 37 1.79e-01 -0.128000 4.95e-01
Nuclear Envelope (NE) Reassembly 68 6.88e-02 -0.128000 2.71e-01
UCH proteinases 73 6.07e-02 -0.127000 2.50e-01
Physiological factors 9 5.10e-01 0.127000 8.35e-01
Synthesis of substrates in N-glycan biosythesis 59 9.19e-02 -0.127000 3.26e-01
Defects in vitamin and cofactor metabolism 21 3.16e-01 -0.126000 6.71e-01
Defective B4GALT7 causes EDS, progeroid type 12 4.49e-01 -0.126000 7.97e-01
RHOG GTPase cycle 70 6.80e-02 -0.126000 2.70e-01
Presynaptic depolarization and calcium channel opening 8 5.37e-01 0.126000 8.37e-01
Negative regulation of FGFR1 signaling 25 2.76e-01 0.126000 6.30e-01
Formation of apoptosome 11 4.70e-01 0.126000 8.14e-01
Regulation of the apoptosome activity 11 4.70e-01 0.126000 8.14e-01
Protein hydroxylation 17 3.69e-01 -0.126000 7.24e-01
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.34e-02 0.126000 1.31e-01
Early SARS-CoV-2 Infection Events 32 2.19e-01 -0.126000 5.54e-01
M Phase 346 6.15e-05 -0.125000 1.48e-03
RNA Polymerase II Pre-transcription Events 77 5.77e-02 -0.125000 2.42e-01
Glycosphingolipid biosynthesis 15 4.01e-01 -0.125000 7.60e-01
Cell junction organization 78 5.64e-02 -0.125000 2.38e-01
Signaling by NOTCH 173 4.70e-03 -0.125000 3.77e-02
EPHA-mediated growth cone collapse 21 3.24e-01 -0.124000 6.81e-01
PI Metabolism 79 5.61e-02 -0.124000 2.38e-01
Amino acid transport across the plasma membrane 25 2.82e-01 -0.124000 6.35e-01
PKR-mediated signaling 67 7.86e-02 -0.124000 2.91e-01
Peptide hormone metabolism 53 1.18e-01 0.124000 3.88e-01
p75NTR negatively regulates cell cycle via SC1 5 6.31e-01 -0.124000 8.93e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 2.65e-01 -0.124000 6.18e-01
Plasma lipoprotein remodeling 18 3.63e-01 -0.124000 7.23e-01
Cap-dependent Translation Initiation 117 2.07e-02 0.124000 1.21e-01
Eukaryotic Translation Initiation 117 2.07e-02 0.124000 1.21e-01
Signaling by Non-Receptor Tyrosine Kinases 47 1.43e-01 -0.124000 4.35e-01
Signaling by PTK6 47 1.43e-01 -0.124000 4.35e-01
EGFR Transactivation by Gastrin 7 5.72e-01 0.123000 8.54e-01
Small interfering RNA (siRNA) biogenesis 9 5.22e-01 0.123000 8.36e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 6.42e-02 -0.123000 2.60e-01
Asparagine N-linked glycosylation 286 3.58e-04 -0.123000 5.68e-03
Integration of provirus 9 5.24e-01 -0.123000 8.36e-01
AMPK inhibits chREBP transcriptional activation activity 6 6.03e-01 0.123000 8.75e-01
FGFR2 mutant receptor activation 23 3.09e-01 -0.123000 6.64e-01
Intra-Golgi traffic 43 1.64e-01 -0.123000 4.70e-01
Defective B3GALTL causes PpS 27 2.71e-01 -0.122000 6.24e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.47e-01 -0.122000 7.95e-01
SARS-CoV-2-host interactions 182 4.63e-03 -0.122000 3.75e-02
Cholesterol biosynthesis 26 2.83e-01 -0.122000 6.35e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 6.07e-01 0.121000 8.76e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 5.07e-01 -0.121000 8.35e-01
Growth hormone receptor signaling 20 3.48e-01 0.121000 7.07e-01
Processing and activation of SUMO 10 5.07e-01 -0.121000 8.35e-01
Gap junction trafficking 28 2.68e-01 -0.121000 6.20e-01
ERBB2 Activates PTK6 Signaling 8 5.54e-01 0.121000 8.45e-01
Platelet degranulation 105 3.25e-02 0.121000 1.66e-01
Phase 3 - rapid repolarisation 6 6.09e-01 0.120000 8.76e-01
Acetylcholine regulates insulin secretion 9 5.32e-01 -0.120000 8.36e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.82e-01 -0.120000 4.99e-01
Diseases of DNA Double-Strand Break Repair 41 1.82e-01 -0.120000 4.99e-01
Cell-extracellular matrix interactions 15 4.20e-01 -0.120000 7.74e-01
Disease 1623 8.22e-16 -0.120000 7.92e-13
mRNA Capping 29 2.65e-01 -0.120000 6.18e-01
PI3K events in ERBB2 signaling 11 4.93e-01 0.119000 8.33e-01
Transcriptional Regulation by E2F6 34 2.28e-01 -0.119000 5.65e-01
Class I peroxisomal membrane protein import 20 3.55e-01 -0.119000 7.14e-01
Estrogen-dependent gene expression 96 4.41e-02 -0.119000 2.01e-01
Metabolism of water-soluble vitamins and cofactors 116 2.74e-02 -0.119000 1.49e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 3.84e-01 -0.118000 7.39e-01
FGFRL1 modulation of FGFR1 signaling 7 5.88e-01 0.118000 8.64e-01
Synthesis of PA 31 2.55e-01 0.118000 6.06e-01
Retinoid metabolism and transport 25 3.07e-01 -0.118000 6.61e-01
Phase II - Conjugation of compounds 70 8.83e-02 0.118000 3.18e-01
Folding of actin by CCT/TriC 10 5.19e-01 -0.118000 8.36e-01
Cell Cycle Checkpoints 246 1.49e-03 -0.118000 1.66e-02
Response to elevated platelet cytosolic Ca2+ 109 3.39e-02 0.118000 1.71e-01
G2 Phase 5 6.49e-01 -0.117000 9.01e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.64e-01 0.117000 7.23e-01
Regulation of TLR by endogenous ligand 15 4.32e-01 0.117000 7.83e-01
RND3 GTPase cycle 35 2.31e-01 -0.117000 5.68e-01
Vitamin D (calciferol) metabolism 11 5.02e-01 -0.117000 8.35e-01
Calcineurin activates NFAT 9 5.44e-01 -0.117000 8.40e-01
PI-3K cascade:FGFR3 10 5.24e-01 0.116000 8.36e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 6.52e-01 -0.116000 9.01e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 6.52e-01 -0.116000 9.01e-01
VEGFR2 mediated vascular permeability 25 3.14e-01 -0.116000 6.70e-01
Diseases of branched-chain amino acid catabolism 13 4.68e-01 0.116000 8.13e-01
TICAM1-dependent activation of IRF3/IRF7 13 4.69e-01 -0.116000 8.13e-01
SARS-CoV-1 modulates host translation machinery 36 2.28e-01 0.116000 5.65e-01
Cell-Cell communication 110 3.55e-02 -0.116000 1.76e-01
Metabolism of fat-soluble vitamins 28 2.89e-01 -0.116000 6.43e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 1.45e-01 -0.116000 4.36e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 1.45e-01 -0.116000 4.36e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 1.45e-01 -0.116000 4.36e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 1.45e-01 -0.116000 4.36e-01
Signaling by NOTCH1 in Cancer 53 1.45e-01 -0.116000 4.36e-01
TNFR1-induced proapoptotic signaling 24 3.27e-01 -0.116000 6.86e-01
Other semaphorin interactions 16 4.24e-01 -0.115000 7.77e-01
Clathrin-mediated endocytosis 126 2.52e-02 -0.115000 1.39e-01
FRS-mediated FGFR1 signaling 15 4.41e-01 0.115000 7.92e-01
Phospholipase C-mediated cascade; FGFR3 5 6.57e-01 0.115000 9.01e-01
Pexophagy 10 5.29e-01 -0.115000 8.36e-01
Signaling by LTK 10 5.30e-01 -0.115000 8.36e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.75e-01 -0.115000 8.17e-01
Regulation of pyruvate metabolism 32 2.63e-01 -0.114000 6.16e-01
RAB GEFs exchange GTP for GDP on RABs 88 6.41e-02 -0.114000 2.59e-01
Cytochrome P450 - arranged by substrate type 39 2.20e-01 0.114000 5.54e-01
Signaling by WNT in cancer 30 2.82e-01 -0.114000 6.35e-01
Lysosome Vesicle Biogenesis 32 2.67e-01 -0.113000 6.19e-01
AKT phosphorylates targets in the nucleus 10 5.35e-01 -0.113000 8.37e-01
Signaling by TGFB family members 137 2.21e-02 -0.113000 1.26e-01
Disorders of transmembrane transporters 136 2.27e-02 -0.113000 1.28e-01
MECP2 regulates neuronal receptors and channels 14 4.64e-01 -0.113000 8.13e-01
Inhibition of DNA recombination at telomere 33 2.62e-01 -0.113000 6.16e-01
Glycosaminoglycan metabolism 98 5.38e-02 -0.113000 2.32e-01
Ketone body metabolism 8 5.81e-01 -0.113000 8.63e-01
RHO GTPase cycle 411 8.96e-05 -0.113000 2.08e-03
Diseases of glycosylation 110 4.15e-02 -0.113000 1.93e-01
Budding and maturation of HIV virion 26 3.22e-01 -0.112000 6.79e-01
Regulation of BACH1 activity 11 5.19e-01 0.112000 8.36e-01
Loss of Function of SMAD2/3 in Cancer 7 6.07e-01 -0.112000 8.76e-01
Signaling by Rho GTPases 607 2.61e-06 -0.112000 1.03e-04
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 623 2.02e-06 -0.111000 8.19e-05
Metabolism of carbohydrates 241 2.89e-03 -0.111000 2.58e-02
Metabolism of steroids 123 3.30e-02 -0.111000 1.68e-01
Mitochondrial calcium ion transport 22 3.67e-01 0.111000 7.24e-01
Sema4D mediated inhibition of cell attachment and migration 7 6.11e-01 -0.111000 8.76e-01
Synthesis of DNA 108 4.64e-02 -0.111000 2.08e-01
Cytosolic tRNA aminoacylation 24 3.48e-01 -0.111000 7.07e-01
Estrogen-stimulated signaling through PRKCZ 6 6.39e-01 0.111000 8.95e-01
Signaling by TGF-beta Receptor Complex 90 7.01e-02 -0.110000 2.73e-01
Adaptive Immune System 771 1.87e-07 -0.110000 9.23e-06
Base-Excision Repair, AP Site Formation 29 3.04e-01 -0.110000 6.60e-01
Vitamin C (ascorbate) metabolism 8 5.90e-01 -0.110000 8.66e-01
G2/M DNA damage checkpoint 66 1.23e-01 -0.110000 3.94e-01
p38MAPK events 13 4.96e-01 -0.109000 8.35e-01
MITF-M-dependent gene expression 84 8.47e-02 -0.109000 3.07e-01
RAC1 GTPase cycle 172 1.39e-02 -0.109000 9.09e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 5.15e-01 -0.108000 8.36e-01
NOTCH2 intracellular domain regulates transcription 11 5.34e-01 -0.108000 8.37e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 4.69e-01 -0.108000 8.13e-01
PTEN Regulation 127 3.55e-02 -0.108000 1.76e-01
Organelle biogenesis and maintenance 278 2.01e-03 -0.108000 2.01e-02
Diseases of signal transduction by growth factor receptors and second messengers 401 2.21e-04 -0.107000 4.21e-03
Activation of HOX genes during differentiation 70 1.20e-01 -0.107000 3.89e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 1.20e-01 -0.107000 3.89e-01
Viral mRNA Translation 87 8.38e-02 0.107000 3.06e-01
Formation of a pool of free 40S subunits 99 6.55e-02 0.107000 2.61e-01
Leading Strand Synthesis 14 4.88e-01 -0.107000 8.30e-01
Polymerase switching 14 4.88e-01 -0.107000 8.30e-01
Nephrin family interactions 20 4.07e-01 -0.107000 7.62e-01
Miro GTPase Cycle 8 6.02e-01 0.107000 8.73e-01
Interleukin-35 Signalling 12 5.22e-01 -0.107000 8.36e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 6.80e-01 0.107000 9.03e-01
Pyruvate metabolism 44 2.23e-01 -0.106000 5.59e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 5.42e-01 0.106000 8.39e-01
Tie2 Signaling 16 4.63e-01 -0.106000 8.13e-01
Uptake and function of diphtheria toxin 6 6.53e-01 0.106000 9.01e-01
p75NTR recruits signalling complexes 12 5.25e-01 0.106000 8.36e-01
EPH-Ephrin signaling 81 1.00e-01 -0.106000 3.40e-01
Platelet Adhesion to exposed collagen 15 4.79e-01 0.106000 8.21e-01
Mitophagy 38 2.60e-01 0.106000 6.14e-01
Glucuronidation 8 6.05e-01 0.106000 8.76e-01
Signaling by PDGFRA extracellular domain mutants 12 5.28e-01 -0.105000 8.36e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 5.28e-01 -0.105000 8.36e-01
Degradation of beta-catenin by the destruction complex 72 1.23e-01 -0.105000 3.94e-01
Retrograde transport at the Trans-Golgi-Network 49 2.03e-01 -0.105000 5.33e-01
Miscellaneous substrates 8 6.08e-01 0.105000 8.76e-01
Regulation of CDH11 gene transcription 5 6.85e-01 -0.105000 9.03e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 6.08e-01 0.105000 8.76e-01
Inhibition of Signaling by Overexpressed EGFR 5 6.86e-01 0.104000 9.03e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 6.86e-01 0.104000 9.03e-01
Nuclear Events (kinase and transcription factor activation) 54 1.85e-01 0.104000 5.02e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 4.31e-01 0.104000 7.83e-01
Ca-dependent events 30 3.23e-01 -0.104000 6.80e-01
FGFR1c ligand binding and activation 8 6.10e-01 0.104000 8.76e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.21e-02 -0.104000 2.28e-01
GRB2 events in EGFR signaling 10 5.70e-01 0.104000 8.53e-01
Peptide chain elongation 87 9.45e-02 0.104000 3.29e-01
Positive epigenetic regulation of rRNA expression 60 1.65e-01 -0.104000 4.71e-01
Dual incision in TC-NER 63 1.56e-01 -0.103000 4.53e-01
Signaling by FGFR in disease 52 2.00e-01 -0.103000 5.28e-01
CD28 dependent Vav1 pathway 12 5.38e-01 -0.103000 8.37e-01
Mitochondrial translation elongation 90 9.27e-02 -0.103000 3.28e-01
Metabolism of vitamins and cofactors 167 2.25e-02 -0.102000 1.28e-01
Arachidonate production from DAG 5 6.92e-01 -0.102000 9.03e-01
E2F mediated regulation of DNA replication 22 4.08e-01 -0.102000 7.62e-01
Cleavage of the damaged purine 22 4.08e-01 -0.102000 7.62e-01
Depurination 22 4.08e-01 -0.102000 7.62e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 4.08e-01 -0.102000 7.62e-01
Metabolism of folate and pterines 16 4.81e-01 -0.102000 8.24e-01
Semaphorin interactions 57 1.86e-01 -0.101000 5.03e-01
Transcriptional Regulation by VENTX 39 2.74e-01 -0.101000 6.28e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 2.17e-01 -0.101000 5.50e-01
RNA polymerase II transcribes snRNA genes 71 1.41e-01 -0.101000 4.34e-01
Biosynthesis of DHA-derived SPMs 14 5.14e-01 0.101000 8.36e-01
TP53 Regulates Transcription of Cell Death Genes 43 2.53e-01 -0.101000 6.04e-01
Platelet homeostasis 69 1.48e-01 -0.101000 4.39e-01
RNA Polymerase III Transcription Initiation 36 2.96e-01 -0.101000 6.52e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 3.04e-01 -0.100000 6.60e-01
Ca2+ pathway 58 1.86e-01 -0.100000 5.03e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 3.67e-01 -0.100000 7.23e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 5.65e-01 0.100000 8.48e-01
Beta-catenin independent WNT signaling 126 5.26e-02 -0.100000 2.29e-01
NFE2L2 regulates pentose phosphate pathway genes 8 6.24e-01 -0.100000 8.86e-01
Scavenging by Class A Receptors 12 5.49e-01 0.099900 8.42e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 6.72e-01 -0.099800 9.01e-01
MAPK3 (ERK1) activation 10 5.85e-01 -0.099800 8.63e-01
RND1 GTPase cycle 36 3.00e-01 -0.099700 6.58e-01
RUNX3 regulates CDKN1A transcription 7 6.48e-01 -0.099700 9.01e-01
Purine catabolism 16 4.91e-01 0.099400 8.33e-01
Phase 2 - plateau phase 11 5.69e-01 0.099200 8.52e-01
Assembly and cell surface presentation of NMDA receptors 34 3.17e-01 0.099200 6.71e-01
Metabolism of RNA 717 6.11e-06 -0.099100 2.14e-04
Presynaptic phase of homologous DNA pairing and strand exchange 40 2.79e-01 -0.099000 6.33e-01
Fertilization 13 5.37e-01 -0.099000 8.37e-01
Signaling by FGFR3 in disease 14 5.22e-01 0.098900 8.36e-01
Opioid Signalling 75 1.39e-01 -0.098700 4.30e-01
Signaling by NTRK2 (TRKB) 20 4.46e-01 -0.098500 7.94e-01
Post-translational protein modification 1245 5.14e-09 -0.098400 4.61e-07
Processing of Capped Intronless Pre-mRNA 29 3.64e-01 -0.097500 7.23e-01
Regulation of TP53 Degradation 35 3.20e-01 -0.097100 6.76e-01
Processing of SMDT1 15 5.15e-01 0.097100 8.36e-01
Eukaryotic Translation Elongation 92 1.08e-01 0.097000 3.62e-01
PCP/CE pathway 75 1.47e-01 -0.096900 4.39e-01
Defective B3GAT3 causes JDSSDHD 12 5.62e-01 -0.096700 8.47e-01
Reversible hydration of carbon dioxide 8 6.37e-01 -0.096300 8.95e-01
SHC1 events in ERBB4 signaling 10 5.98e-01 0.096300 8.72e-01
Negative regulators of DDX58/IFIH1 signaling 34 3.32e-01 -0.096200 6.87e-01
Germ layer formation at gastrulation 9 6.17e-01 -0.096200 8.80e-01
RNA Polymerase I Promoter Escape 45 2.64e-01 0.096200 6.18e-01
Noncanonical activation of NOTCH3 8 6.38e-01 -0.096200 8.95e-01
Interleukin-6 family signaling 20 4.57e-01 0.096000 8.07e-01
Activation of caspases through apoptosome-mediated cleavage 6 6.84e-01 0.095900 9.03e-01
Sensing of DNA Double Strand Breaks 6 6.84e-01 -0.095800 9.03e-01
Receptor Mediated Mitophagy 11 5.82e-01 -0.095800 8.63e-01
Hemostasis 558 1.11e-04 -0.095700 2.54e-03
Mitotic Metaphase and Anaphase 212 1.64e-02 -0.095700 1.01e-01
IRAK2 mediated activation of TAK1 complex 10 6.00e-01 0.095700 8.73e-01
Mitochondrial translation initiation 90 1.17e-01 -0.095500 3.88e-01
Gap junction trafficking and regulation 30 3.67e-01 -0.095200 7.23e-01
Fibronectin matrix formation 6 6.86e-01 -0.095200 9.03e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.98e-01 0.094900 8.35e-01
Cilium Assembly 187 2.53e-02 -0.094800 1.39e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 6.23e-01 -0.094700 8.86e-01
activated TAK1 mediates p38 MAPK activation 23 4.32e-01 0.094600 7.83e-01
Erythropoietin activates RAS 13 5.55e-01 -0.094600 8.45e-01
Defects in cobalamin (B12) metabolism 13 5.56e-01 -0.094200 8.46e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 6.90e-01 0.094100 9.03e-01
Meiosis 67 1.84e-01 -0.094000 5.00e-01
Recycling pathway of L1 40 3.04e-01 -0.093800 6.60e-01
Interleukin-7 signaling 21 4.57e-01 -0.093800 8.07e-01
rRNA modification in the nucleus and cytosol 60 2.11e-01 -0.093300 5.46e-01
Mitotic Anaphase 211 1.97e-02 -0.093100 1.16e-01
tRNA processing 128 6.93e-02 -0.093000 2.73e-01
tRNA modification in the mitochondrion 9 6.29e-01 0.093000 8.91e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.72e-01 0.092700 7.24e-01
Methionine salvage pathway 6 6.94e-01 0.092700 9.03e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 5.63e-01 -0.092500 8.48e-01
Smooth Muscle Contraction 34 3.51e-01 0.092500 7.09e-01
Antimicrobial peptides 34 3.51e-01 0.092400 7.09e-01
SRP-dependent cotranslational protein targeting to membrane 110 9.42e-02 0.092400 3.29e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 5.00e-01 0.091900 8.35e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 5.02e-01 -0.091400 8.35e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 5.02e-01 -0.091400 8.35e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 7.23e-01 -0.091400 9.11e-01
GRB2 events in ERBB2 signaling 11 6.00e-01 0.091300 8.73e-01
Metalloprotease DUBs 20 4.80e-01 0.091300 8.22e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 5.85e-01 -0.091000 8.63e-01
Translesion synthesis by REV1 16 5.30e-01 -0.090600 8.36e-01
Deubiquitination 225 1.92e-02 -0.090600 1.14e-01
Synthesis of PIPs at the early endosome membrane 16 5.30e-01 -0.090600 8.36e-01
Synthesis of UDP-N-acetyl-glucosamine 8 6.59e-01 -0.090100 9.01e-01
SLC-mediated transmembrane transport 174 4.03e-02 -0.090100 1.89e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 5.21e-01 -0.089900 8.36e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 6.60e-01 -0.089800 9.01e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.65e-01 -0.089800 7.23e-01
Cell recruitment (pro-inflammatory response) 25 4.37e-01 0.089800 7.86e-01
Purinergic signaling in leishmaniasis infection 25 4.37e-01 0.089800 7.86e-01
Synthesis of Ketone Bodies 6 7.04e-01 -0.089700 9.05e-01
Activated point mutants of FGFR2 7 6.81e-01 0.089700 9.03e-01
Regulation of TP53 Activity through Phosphorylation 88 1.46e-01 -0.089700 4.37e-01
Netrin mediated repulsion signals 5 7.28e-01 -0.089700 9.12e-01
Signaling by LTK in cancer 7 6.81e-01 -0.089600 9.03e-01
RHO GTPases activate PKNs 46 2.93e-01 0.089600 6.49e-01
O-linked glycosylation 85 1.54e-01 -0.089500 4.49e-01
Insulin receptor recycling 24 4.49e-01 0.089400 7.97e-01
Interleukin-27 signaling 11 6.08e-01 -0.089300 8.76e-01
SHC-mediated cascade:FGFR3 10 6.26e-01 0.088900 8.88e-01
Cobalamin (Cbl) metabolism 7 6.84e-01 -0.088800 9.03e-01
Intrinsic Pathway for Apoptosis 54 2.61e-01 -0.088400 6.16e-01
Metal ion SLC transporters 19 5.05e-01 -0.088400 8.35e-01
Signal Transduction 2051 4.48e-11 -0.088200 7.20e-09
Immune System 1841 4.14e-10 -0.087800 5.16e-08
Glycogen breakdown (glycogenolysis) 13 5.84e-01 -0.087700 8.63e-01
Signal regulatory protein family interactions 13 5.85e-01 -0.087400 8.63e-01
G beta:gamma signalling through PI3Kgamma 22 4.78e-01 -0.087400 8.21e-01
Keratinization 38 3.52e-01 0.087300 7.10e-01
FGFR4 ligand binding and activation 5 7.36e-01 0.087200 9.17e-01
Signaling by FLT3 ITD and TKD mutants 15 5.59e-01 -0.087100 8.46e-01
Recognition of DNA damage by PCNA-containing replication complex 30 4.09e-01 -0.087000 7.64e-01
RHO GTPases Activate WASPs and WAVEs 35 3.73e-01 -0.087000 7.24e-01
ATF6 (ATF6-alpha) activates chaperones 12 6.02e-01 -0.086900 8.74e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 6.71e-01 0.086700 9.01e-01
Formation of paraxial mesoderm 52 2.80e-01 -0.086500 6.34e-01
Signaling by NOTCH3 42 3.32e-01 -0.086500 6.87e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 6.04e-01 -0.086500 8.75e-01
Mitochondrial translation termination 90 1.57e-01 -0.086200 4.54e-01
Bile acid and bile salt metabolism 30 4.15e-01 -0.086000 7.70e-01
Translesion Synthesis by POLH 18 5.28e-01 -0.086000 8.36e-01
EPHB-mediated forward signaling 40 3.47e-01 -0.086000 7.06e-01
Digestion and absorption 7 6.94e-01 -0.085700 9.03e-01
SARS-CoV-1 Infection 137 8.38e-02 -0.085600 3.06e-01
Collagen biosynthesis and modifying enzymes 46 3.16e-01 -0.085400 6.71e-01
Protein folding 83 1.80e-01 -0.085200 4.96e-01
Trafficking and processing of endosomal TLR 13 5.96e-01 -0.085000 8.72e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 5.69e-01 -0.085000 8.52e-01
NADE modulates death signalling 5 7.43e-01 -0.084800 9.20e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 5.84e-01 -0.084600 8.63e-01
Neurexins and neuroligins 38 3.68e-01 -0.084400 7.24e-01
G beta:gamma signalling through PLC beta 17 5.51e-01 -0.083500 8.42e-01
Presynaptic function of Kainate receptors 17 5.51e-01 -0.083500 8.42e-01
Selenocysteine synthesis 91 1.69e-01 0.083400 4.76e-01
Bacterial Infection Pathways 65 2.45e-01 -0.083300 5.92e-01
Cellular response to chemical stress 179 5.50e-02 -0.083100 2.35e-01
Negative regulation of FGFR3 signaling 21 5.10e-01 0.083100 8.35e-01
Killing mechanisms 10 6.49e-01 0.083000 9.01e-01
WNT5:FZD7-mediated leishmania damping 10 6.49e-01 0.083000 9.01e-01
FGFR2 alternative splicing 25 4.72e-01 -0.083000 8.15e-01
MAPK1 (ERK2) activation 9 6.67e-01 -0.082800 9.01e-01
Pre-NOTCH Transcription and Translation 47 3.29e-01 -0.082300 6.86e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 5.25e-01 -0.082200 8.36e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 4.17e-01 -0.081600 7.70e-01
Orc1 removal from chromatin 58 2.83e-01 -0.081600 6.35e-01
Signaling by Hedgehog 121 1.21e-01 -0.081500 3.91e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 7.09e-01 0.081500 9.07e-01
RHO GTPase Effectors 259 2.45e-02 -0.081100 1.36e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 7.31e-01 0.081100 9.13e-01
Chaperonin-mediated protein folding 77 2.19e-01 -0.081100 5.54e-01
Cleavage of the damaged pyrimidine 27 4.67e-01 -0.080800 8.13e-01
Depyrimidination 27 4.67e-01 -0.080800 8.13e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 4.67e-01 -0.080800 8.13e-01
Regulation of gene expression in beta cells 8 6.92e-01 -0.080800 9.03e-01
Neddylation 216 4.08e-02 -0.080700 1.91e-01
Glycosphingolipid metabolism 46 3.43e-01 0.080700 7.02e-01
Striated Muscle Contraction 27 4.68e-01 0.080600 8.13e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 2.31e-01 -0.080600 5.68e-01
Cytokine Signaling in Immune system 668 3.86e-04 -0.080500 5.91e-03
Formation of the cornified envelope 37 3.97e-01 0.080500 7.54e-01
RNA Polymerase III Abortive And Retractive Initiation 40 3.79e-01 -0.080400 7.33e-01
RNA Polymerase III Transcription 40 3.79e-01 -0.080400 7.33e-01
Calnexin/calreticulin cycle 26 4.79e-01 -0.080200 8.21e-01
Thromboxane signalling through TP receptor 20 5.36e-01 -0.080000 8.37e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.83e-01 0.079900 4.99e-01
Sulfide oxidation to sulfate 5 7.58e-01 -0.079600 9.23e-01
Eukaryotic Translation Termination 91 1.91e-01 0.079300 5.13e-01
tRNA processing in the mitochondrion 24 5.02e-01 0.079100 8.35e-01
Cell-cell junction organization 57 3.02e-01 -0.079100 6.59e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 5.31e-01 0.079000 8.36e-01
Separation of Sister Chromatids 168 7.73e-02 -0.079000 2.89e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 5.97e-01 0.078900 8.72e-01
Uptake and function of anthrax toxins 11 6.51e-01 -0.078900 9.01e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 5.42e-01 0.078900 8.39e-01
Depolymerization of the Nuclear Lamina 15 5.98e-01 -0.078600 8.72e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 6.37e-01 0.078600 8.95e-01
alpha-linolenic acid (ALA) metabolism 12 6.37e-01 0.078600 8.95e-01
Signaling by FGFR2 in disease 33 4.36e-01 -0.078400 7.86e-01
Blood group systems biosynthesis 17 5.76e-01 0.078300 8.57e-01
Creatine metabolism 6 7.40e-01 -0.078100 9.19e-01
Regulation of CDH19 Expression and Function 6 7.41e-01 -0.077900 9.19e-01
Chemokine receptors bind chemokines 41 3.89e-01 0.077700 7.46e-01
TCR signaling 110 1.60e-01 -0.077600 4.59e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 5.69e-01 -0.077600 8.52e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 6.72e-01 0.077300 9.01e-01
Formation of definitive endoderm 9 6.88e-01 0.077300 9.03e-01
Aggrephagy 34 4.35e-01 0.077300 7.86e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.21e-01 -0.077300 5.55e-01
Activation of G protein gated Potassium channels 19 5.60e-01 0.077200 8.46e-01
G protein gated Potassium channels 19 5.60e-01 0.077200 8.46e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 5.60e-01 0.077200 8.46e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 7.24e-01 -0.077200 9.11e-01
Interleukin-37 signaling 19 5.60e-01 -0.077200 8.46e-01
Cytosolic sulfonation of small molecules 18 5.72e-01 0.077000 8.54e-01
Downstream signaling of activated FGFR1 22 5.32e-01 0.077000 8.36e-01
Formation of TC-NER Pre-Incision Complex 51 3.43e-01 -0.076800 7.01e-01
Signaling by BRAF and RAF1 fusions 60 3.05e-01 0.076600 6.60e-01
Reproduction 86 2.21e-01 -0.076400 5.55e-01
Diseases associated with glycosaminoglycan metabolism 26 5.00e-01 -0.076400 8.35e-01
Diseases of mitotic cell cycle 38 4.17e-01 -0.076100 7.70e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 3.12e-01 -0.076100 6.67e-01
G alpha (q) signalling events 139 1.22e-01 -0.075900 3.93e-01
Synthesis of PC 23 5.29e-01 0.075800 8.36e-01
Transport and synthesis of PAPS 6 7.48e-01 0.075700 9.20e-01
SUMOylation of intracellular receptors 26 5.05e-01 -0.075600 8.35e-01
Signaling by NOTCH2 33 4.53e-01 -0.075500 8.02e-01
Sialic acid metabolism 28 4.91e-01 -0.075200 8.33e-01
Methylation 13 6.39e-01 0.075100 8.95e-01
Selenoamino acid metabolism 114 1.67e-01 0.074900 4.73e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 4.93e-01 -0.074800 8.33e-01
A tetrasaccharide linker sequence is required for GAG synthesis 18 5.85e-01 -0.074400 8.63e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 4.22e-01 -0.074300 7.76e-01
NrCAM interactions 6 7.53e-01 -0.074300 9.22e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 4.47e-01 -0.074300 7.95e-01
Cyclin A:Cdk2-associated events at S phase entry 75 2.66e-01 -0.074300 6.19e-01
VEGF binds to VEGFR leading to receptor dimerization 5 7.74e-01 0.074100 9.30e-01
VEGF ligand-receptor interactions 5 7.74e-01 0.074100 9.30e-01
GABA receptor activation 36 4.42e-01 0.074100 7.92e-01
Metabolism of nucleotides 85 2.38e-01 -0.074100 5.79e-01
Phase I - Functionalization of compounds 68 2.91e-01 0.074100 6.45e-01
TGF-beta receptor signaling activates SMADs 45 3.93e-01 -0.073600 7.48e-01
Frs2-mediated activation 11 6.74e-01 0.073400 9.01e-01
E2F-enabled inhibition of pre-replication complex formation 9 7.03e-01 -0.073300 9.05e-01
RAS processing 23 5.44e-01 0.073100 8.40e-01
Biological oxidations 143 1.32e-01 0.073000 4.15e-01
Vitamin B1 (thiamin) metabolism 5 7.78e-01 0.072900 9.30e-01
Peptide ligand-binding receptors 102 2.04e-01 0.072800 5.35e-01
Somitogenesis 41 4.22e-01 -0.072500 7.76e-01
Post-translational modification: synthesis of GPI-anchored proteins 60 3.32e-01 0.072400 6.87e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 4.41e-01 -0.072200 7.92e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 4.25e-01 -0.072000 7.77e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 7.42e-01 -0.071800 9.20e-01
Cellular Senescence 143 1.38e-01 -0.071800 4.29e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 5.51e-01 0.071800 8.42e-01
Signaling by RNF43 mutants 7 7.43e-01 -0.071700 9.20e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 4.20e-02 -0.071100 1.94e-01
Regulated Necrosis 56 3.57e-01 -0.071100 7.16e-01
DNA Replication 128 1.65e-01 -0.071100 4.70e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 7.45e-01 -0.070900 9.20e-01
DARPP-32 events 22 5.65e-01 -0.070900 8.48e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 7.84e-01 -0.070800 9.30e-01
Mitochondrial translation 96 2.31e-01 -0.070700 5.68e-01
Na+/Cl- dependent neurotransmitter transporters 8 7.29e-01 0.070700 9.12e-01
FasL/ CD95L signaling 5 7.85e-01 -0.070500 9.30e-01
Keratan sulfate/keratin metabolism 28 5.19e-01 -0.070500 8.36e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 5.42e-01 -0.070400 8.39e-01
Protein methylation 15 6.37e-01 0.070300 8.95e-01
Beta-catenin phosphorylation cascade 17 6.16e-01 -0.070200 8.79e-01
RAC2 GTPase cycle 85 2.64e-01 -0.070200 6.17e-01
Prolonged ERK activation events 13 6.63e-01 0.069900 9.01e-01
RA biosynthesis pathway 13 6.64e-01 -0.069700 9.01e-01
Cellular responses to stress 697 1.76e-03 -0.069500 1.84e-02
Regulation of TP53 Expression and Degradation 36 4.70e-01 -0.069500 8.14e-01
Eicosanoid ligand-binding receptors 13 6.65e-01 0.069500 9.01e-01
ERKs are inactivated 13 6.65e-01 -0.069300 9.01e-01
Negative regulation of MET activity 18 6.11e-01 -0.069300 8.76e-01
SUMO is proteolytically processed 6 7.69e-01 -0.069200 9.30e-01
Meiotic synapsis 43 4.33e-01 -0.069100 7.83e-01
MAP kinase activation 63 3.46e-01 0.068700 7.05e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.93e-01 -0.068700 9.03e-01
Regulation of TNFR1 signaling 47 4.17e-01 -0.068500 7.70e-01
RUNX3 regulates NOTCH signaling 14 6.57e-01 -0.068500 9.01e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 5.17e-01 -0.068400 8.36e-01
Activation of BH3-only proteins 30 5.19e-01 -0.068100 8.36e-01
Innate Immune System 970 3.33e-04 -0.068000 5.49e-03
Interaction between L1 and Ankyrins 27 5.41e-01 -0.067900 8.39e-01
Metabolism of proteins 1775 2.04e-06 -0.067900 8.19e-05
Cellular response to starvation 147 1.56e-01 0.067800 4.53e-01
Azathioprine ADME 20 6.01e-01 -0.067600 8.73e-01
FGFR1b ligand binding and activation 5 7.94e-01 -0.067400 9.33e-01
ESR-mediated signaling 157 1.45e-01 -0.067400 4.36e-01
MITF-M-regulated melanocyte development 113 2.16e-01 -0.067400 5.50e-01
Gamma-carboxylation of protein precursors 6 7.75e-01 -0.067300 9.30e-01
Synthesis of diphthamide-EEF2 8 7.44e-01 0.066800 9.20e-01
MASTL Facilitates Mitotic Progression 10 7.15e-01 -0.066700 9.08e-01
KEAP1-NFE2L2 pathway 107 2.33e-01 -0.066700 5.71e-01
Aspirin ADME 15 6.55e-01 -0.066600 9.01e-01
CHL1 interactions 8 7.46e-01 0.066200 9.20e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 7.98e-01 -0.066100 9.33e-01
Nucleotide catabolism 28 5.46e-01 0.065900 8.41e-01
TYSND1 cleaves peroxisomal proteins 7 7.64e-01 0.065600 9.27e-01
Intracellular signaling by second messengers 267 6.57e-02 -0.065400 2.61e-01
Butyrophilin (BTN) family interactions 10 7.20e-01 -0.065400 9.10e-01
Aryl hydrocarbon receptor signalling 6 7.82e-01 -0.065300 9.30e-01
Synthesis of PIPs at the plasma membrane 52 4.16e-01 -0.065300 7.70e-01
Phenylalanine metabolism 5 8.01e-01 0.065200 9.34e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 6.53e-01 -0.064900 9.01e-01
Potassium Channels 64 3.72e-01 0.064600 7.24e-01
NOD1/2 Signaling Pathway 36 5.02e-01 0.064600 8.35e-01
Cellular responses to stimuli 778 2.34e-03 -0.064100 2.24e-02
Endosomal/Vacuolar pathway 12 7.03e-01 0.063600 9.05e-01
Amino acids regulate mTORC1 48 4.46e-01 -0.063500 7.95e-01
CREB phosphorylation 7 7.71e-01 -0.063500 9.30e-01
Activation of AMPK downstream of NMDARs 20 6.23e-01 0.063400 8.86e-01
Cardiac conduction 89 3.03e-01 -0.063200 6.60e-01
SHC1 events in ERBB2 signaling 17 6.52e-01 0.063100 9.01e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 5.12e-01 -0.063100 8.36e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.83e-01 -0.063100 9.03e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.83e-01 -0.063100 9.03e-01
Transport of small molecules 556 1.13e-02 -0.062800 7.64e-02
Neurotransmitter release cycle 35 5.20e-01 -0.062800 8.36e-01
Transcriptional regulation of pluripotent stem cells 19 6.36e-01 0.062700 8.95e-01
Deadenylation-dependent mRNA decay 50 4.44e-01 -0.062500 7.94e-01
Acyl chain remodelling of PC 19 6.37e-01 0.062500 8.95e-01
Ion channel transport 141 2.02e-01 -0.062300 5.31e-01
Downstream TCR signaling 89 3.10e-01 -0.062300 6.65e-01
Autophagy 142 2.01e-01 -0.062200 5.29e-01
Proton-coupled monocarboxylate transport 6 7.92e-01 -0.062200 9.33e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 6.98e-01 -0.062100 9.04e-01
Influenza Infection 153 1.85e-01 -0.062100 5.02e-01
Collagen formation 64 3.92e-01 -0.061900 7.46e-01
Cargo trafficking to the periciliary membrane 48 4.59e-01 -0.061700 8.10e-01
Glutamate and glutamine metabolism 12 7.11e-01 0.061700 9.07e-01
The NLRP3 inflammasome 16 6.70e-01 -0.061600 9.01e-01
RHOBTB GTPase Cycle 35 5.29e-01 -0.061600 8.36e-01
APC-Cdc20 mediated degradation of Nek2A 26 5.87e-01 0.061500 8.64e-01
Sensory Perception 194 1.40e-01 0.061500 4.30e-01
Prostacyclin signalling through prostacyclin receptor 16 6.71e-01 -0.061300 9.01e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 6.12e-01 -0.061100 8.77e-01
Downstream signaling of activated FGFR4 18 6.55e-01 -0.060900 9.01e-01
Nonhomologous End-Joining (NHEJ) 40 5.05e-01 -0.060900 8.35e-01
FRS-mediated FGFR3 signaling 12 7.16e-01 0.060700 9.08e-01
IKK complex recruitment mediated by RIP1 23 6.14e-01 0.060700 8.78e-01
G-protein activation 19 6.48e-01 -0.060600 9.01e-01
Cyclin E associated events during G1/S transition 73 3.73e-01 -0.060300 7.24e-01
Processing of Intronless Pre-mRNAs 20 6.41e-01 -0.060300 8.95e-01
Metabolism of amino acids and derivatives 305 7.02e-02 0.060300 2.73e-01
Diseases of programmed cell death 58 4.29e-01 -0.060000 7.82e-01
Regulation of localization of FOXO transcription factors 12 7.20e-01 0.059800 9.10e-01
NRIF signals cell death from the nucleus 15 6.89e-01 0.059700 9.03e-01
CTLA4 inhibitory signaling 21 6.36e-01 -0.059700 8.95e-01
Formation of tubulin folding intermediates by CCT/TriC 21 6.38e-01 0.059400 8.95e-01
Complex III assembly 23 6.23e-01 -0.059300 8.86e-01
Sphingolipid metabolism 92 3.27e-01 0.059100 6.86e-01
Glutathione synthesis and recycling 10 7.46e-01 -0.059100 9.20e-01
Pyrimidine catabolism 9 7.59e-01 0.059000 9.23e-01
CLEC7A/inflammasome pathway 6 8.03e-01 -0.058900 9.35e-01
Signaling by high-kinase activity BRAF mutants 33 5.59e-01 0.058800 8.46e-01
Protein lipoylation 10 7.47e-01 0.058800 9.20e-01
Regulation of NF-kappa B signaling 18 6.67e-01 -0.058500 9.01e-01
Long-term potentiation 18 6.68e-01 0.058400 9.01e-01
Signaling by EGFR in Cancer 22 6.38e-01 -0.058000 8.95e-01
Signaling by Leptin 10 7.52e-01 0.057800 9.22e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 6.32e-01 0.057800 8.93e-01
Formation of Incision Complex in GG-NER 43 5.12e-01 0.057700 8.36e-01
Deadenylation of mRNA 22 6.39e-01 -0.057700 8.95e-01
Signaling by GPCR 446 3.68e-02 -0.057700 1.79e-01
Myogenesis 20 6.56e-01 -0.057600 9.01e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 4.92e-01 -0.057300 8.33e-01
MET receptor recycling 9 7.66e-01 0.057200 9.29e-01
Cellular responses to mechanical stimuli 82 3.71e-01 -0.057100 7.24e-01
Response of endothelial cells to shear stress 82 3.71e-01 -0.057100 7.24e-01
FGFR2 ligand binding and activation 9 7.67e-01 -0.057100 9.29e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 3.05e-01 0.057100 6.60e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 3.05e-01 0.057100 6.60e-01
Switching of origins to a post-replicative state 79 3.81e-01 -0.057000 7.37e-01
APC truncation mutants have impaired AXIN binding 14 7.12e-01 -0.057000 9.07e-01
AXIN missense mutants destabilize the destruction complex 14 7.12e-01 -0.057000 9.07e-01
Signaling by AMER1 mutants 14 7.12e-01 -0.057000 9.07e-01
Signaling by APC mutants 14 7.12e-01 -0.057000 9.07e-01
Signaling by AXIN mutants 14 7.12e-01 -0.057000 9.07e-01
Truncations of AMER1 destabilize the destruction complex 14 7.12e-01 -0.057000 9.07e-01
Dual Incision in GG-NER 41 5.28e-01 -0.057000 8.36e-01
TNF signaling 56 4.61e-01 -0.056900 8.12e-01
Ethanol oxidation 7 7.94e-01 -0.056900 9.33e-01
Activation of RAC1 downstream of NMDARs 7 7.97e-01 -0.056300 9.33e-01
ROS and RNS production in phagocytes 30 5.96e-01 0.056000 8.72e-01
Fatty acid metabolism 157 2.31e-01 0.055400 5.68e-01
Oncogenic MAPK signaling 76 4.06e-01 0.055200 7.62e-01
GPCR downstream signalling 399 5.96e-02 -0.055000 2.48e-01
Class I MHC mediated antigen processing & presentation 345 7.99e-02 -0.054900 2.95e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 7.53e-01 -0.054700 9.22e-01
Chondroitin sulfate biosynthesis 12 7.43e-01 -0.054700 9.20e-01
WNT ligand biogenesis and trafficking 20 6.74e-01 0.054300 9.01e-01
Cargo concentration in the ER 31 6.01e-01 -0.054200 8.73e-01
Transport of RCbl within the body 8 7.91e-01 0.054200 9.33e-01
Signaling by FGFR2 61 4.64e-01 -0.054200 8.13e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 6.99e-01 -0.054200 9.04e-01
FOXO-mediated transcription of cell cycle genes 14 7.26e-01 0.054000 9.12e-01
Linoleic acid (LA) metabolism 7 8.05e-01 0.054000 9.35e-01
Signaling by ERBB4 45 5.35e-01 0.053500 8.37e-01
Activation of C3 and C5 7 8.07e-01 -0.053200 9.36e-01
Apoptotic execution phase 46 5.33e-01 0.053200 8.37e-01
Developmental Biology 924 6.19e-03 -0.053100 4.59e-02
RAF activation 33 5.98e-01 0.053000 8.72e-01
Influenza Viral RNA Transcription and Replication 134 2.90e-01 -0.053000 6.45e-01
DNA Replication Pre-Initiation 103 3.54e-01 -0.052800 7.13e-01
Activated NTRK2 signals through FRS2 and FRS3 8 7.96e-01 -0.052800 9.33e-01
Toll Like Receptor 2 (TLR2) Cascade 109 3.41e-01 0.052700 6.99e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 3.41e-01 0.052700 6.99e-01
RUNX2 regulates osteoblast differentiation 19 6.92e-01 0.052500 9.03e-01
VEGFR2 mediated cell proliferation 18 7.00e-01 -0.052400 9.04e-01
Senescence-Associated Secretory Phenotype (SASP) 65 4.66e-01 0.052300 8.13e-01
FGFR3 ligand binding and activation 5 8.40e-01 0.052100 9.49e-01
FGFR3c ligand binding and activation 5 8.40e-01 0.052100 9.49e-01
Integrin cell surface interactions 65 4.68e-01 0.052100 8.13e-01
Antigen processing-Cross presentation 89 3.96e-01 0.052100 7.53e-01
Triglyceride metabolism 24 6.59e-01 0.052000 9.01e-01
Transcriptional regulation by RUNX1 170 2.42e-01 -0.052000 5.87e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 8.26e-01 0.051700 9.45e-01
PIP3 activates AKT signaling 234 1.74e-01 -0.051600 4.85e-01
Amine ligand-binding receptors 10 7.78e-01 0.051500 9.30e-01
GPER1 signaling 38 5.84e-01 -0.051300 8.63e-01
APC/C:Cdc20 mediated degradation of Securin 55 5.10e-01 0.051300 8.35e-01
Sema4D in semaphorin signaling 22 6.77e-01 -0.051300 9.03e-01
Interleukin-12 family signaling 53 5.19e-01 -0.051200 8.36e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 6.85e-01 0.051200 9.03e-01
Neurodegenerative Diseases 21 6.85e-01 0.051200 9.03e-01
SCF-beta-TrCP mediated degradation of Emi1 42 5.67e-01 -0.051100 8.51e-01
Negative regulation of FGFR2 signaling 24 6.66e-01 0.050900 9.01e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 7.25e-01 0.050900 9.11e-01
RHO GTPases activate PAKs 20 6.94e-01 -0.050800 9.03e-01
Activation of RAS in B cells 5 8.45e-01 -0.050500 9.49e-01
Nuclear events mediated by NFE2L2 82 4.31e-01 -0.050300 7.83e-01
Kidney development 17 7.20e-01 0.050100 9.10e-01
Signaling by EGFR 47 5.53e-01 -0.050000 8.44e-01
RHOJ GTPase cycle 49 5.47e-01 -0.049700 8.42e-01
PI-3K cascade:FGFR2 13 7.58e-01 0.049400 9.23e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 7.97e-01 0.049400 9.33e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 8.49e-01 0.049100 9.50e-01
Regulation of beta-cell development 22 6.91e-01 -0.049000 9.03e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 5.87e-01 -0.049000 8.64e-01
DCC mediated attractive signaling 13 7.61e-01 -0.048700 9.24e-01
Signaling by CSF3 (G-CSF) 29 6.50e-01 -0.048700 9.01e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 6.99e-01 0.048700 9.04e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 6.99e-01 0.048700 9.04e-01
Translesion synthesis by POLK 17 7.28e-01 -0.048600 9.12e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 7.45e-01 0.048500 9.20e-01
Signal transduction by L1 20 7.10e-01 0.048000 9.07e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 7.24e-01 -0.048000 9.11e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 7.83e-01 0.048000 9.30e-01
IGF1R signaling cascade 37 6.13e-01 -0.048000 8.78e-01
rRNA processing in the mitochondrion 24 6.84e-01 0.048000 9.03e-01
RNA Polymerase I Transcription Termination 30 6.50e-01 0.047900 9.01e-01
SARS-CoV-1-host interactions 94 4.22e-01 -0.047900 7.76e-01
Regulation of ornithine decarboxylase (ODC) 38 6.11e-01 0.047700 8.76e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 7.19e-01 0.047700 9.10e-01
Post-chaperonin tubulin folding pathway 18 7.27e-01 0.047500 9.12e-01
Free fatty acids regulate insulin secretion 10 7.95e-01 0.047400 9.33e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 7.59e-01 0.047300 9.23e-01
Ub-specific processing proteases 153 3.14e-01 -0.047200 6.70e-01
Chaperone Mediated Autophagy 20 7.15e-01 0.047100 9.08e-01
Regulation of RAS by GAPs 55 5.46e-01 -0.047000 8.41e-01
Degradation of GLI1 by the proteasome 46 5.82e-01 -0.047000 8.63e-01
CREB3 factors activate genes 6 8.42e-01 0.046900 9.49e-01
Integrin signaling 22 7.03e-01 0.046900 9.05e-01
Negative regulation of FGFR4 signaling 22 7.04e-01 0.046800 9.05e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 7.98e-01 0.046700 9.33e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.69e-01 -0.046700 9.01e-01
G alpha (i) signalling events 196 2.62e-01 0.046500 6.16e-01
Protein ubiquitination 71 4.99e-01 -0.046300 8.35e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 7.20e-01 -0.046200 9.10e-01
RAS signaling downstream of NF1 loss-of-function variants 7 8.32e-01 -0.046200 9.48e-01
Hedgehog ‘off’ state 92 4.44e-01 -0.046200 7.94e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 76 4.87e-01 0.046100 8.30e-01
Synthesis of bile acids and bile salts 26 6.84e-01 -0.046100 9.03e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 6.53e-01 -0.046000 9.01e-01
Interleukin-1 signaling 99 4.31e-01 0.045800 7.83e-01
Nuclear signaling by ERBB4 24 6.98e-01 -0.045800 9.04e-01
Diseases associated with the TLR signaling cascade 29 6.70e-01 -0.045800 9.01e-01
Diseases of Immune System 29 6.70e-01 -0.045800 9.01e-01
RNA Polymerase III Chain Elongation 18 7.39e-01 -0.045400 9.18e-01
Signaling by RAF1 mutants 37 6.33e-01 0.045300 8.95e-01
Downstream signaling of activated FGFR2 20 7.26e-01 -0.045200 9.12e-01
RNA Polymerase I Promoter Clearance 64 5.32e-01 -0.045200 8.36e-01
RNA Polymerase I Transcription 64 5.32e-01 -0.045200 8.36e-01
Pyrimidine salvage 10 8.04e-01 -0.045200 9.35e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 6.84e-01 -0.045200 9.03e-01
CASP8 activity is inhibited 11 7.95e-01 -0.045200 9.33e-01
Dimerization of procaspase-8 11 7.95e-01 -0.045200 9.33e-01
Regulation by c-FLIP 11 7.95e-01 -0.045200 9.33e-01
PI3K/AKT Signaling in Cancer 84 4.77e-01 -0.044900 8.20e-01
Signaling by FGFR1 42 6.16e-01 0.044800 8.79e-01
Signaling by FGFR 73 5.09e-01 -0.044700 8.35e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 7.05e-01 0.044700 9.05e-01
ADORA2B mediated anti-inflammatory cytokines production 36 6.45e-01 -0.044400 8.98e-01
Regulation of APC/C activators between G1/S and early anaphase 68 5.27e-01 -0.044400 8.36e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 5.77e-01 0.043900 8.57e-01
Degradation of DVL 43 6.18e-01 -0.043900 8.81e-01
PRC2 methylates histones and DNA 27 6.94e-01 -0.043800 9.03e-01
Signaling by FGFR4 in disease 11 8.02e-01 -0.043700 9.34e-01
FGFR1 mutant receptor activation 25 7.05e-01 -0.043700 9.05e-01
Activated NTRK2 signals through RAS 6 8.53e-01 -0.043700 9.52e-01
Activated NTRK3 signals through RAS 6 8.53e-01 -0.043700 9.52e-01
RHOF GTPase cycle 38 6.42e-01 -0.043600 8.97e-01
G beta:gamma signalling through BTK 15 7.70e-01 -0.043600 9.30e-01
RET signaling 32 6.73e-01 -0.043100 9.01e-01
G beta:gamma signalling through CDC42 17 7.59e-01 0.042900 9.23e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 5.96e-01 -0.042600 8.72e-01
Regulation of Apoptosis 40 6.43e-01 0.042300 8.97e-01
RHO GTPases Activate ROCKs 18 7.58e-01 0.042000 9.23e-01
Triglyceride catabolism 15 7.79e-01 -0.041900 9.30e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 7.79e-01 -0.041800 9.30e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 7.79e-01 -0.041800 9.30e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 7.79e-01 -0.041800 9.30e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 7.79e-01 -0.041800 9.30e-01
Signaling by CTNNB1 phospho-site mutants 15 7.79e-01 -0.041800 9.30e-01
Signaling by GSK3beta mutants 15 7.79e-01 -0.041800 9.30e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 7.74e-01 0.041600 9.30e-01
Metabolism 1827 3.23e-03 -0.041600 2.80e-02
Activation of kainate receptors upon glutamate binding 26 7.15e-01 -0.041400 9.08e-01
Acyl chain remodeling of CL 5 8.73e-01 -0.041400 9.56e-01
Interleukin-1 family signaling 127 4.21e-01 0.041300 7.76e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 8.61e-01 0.041300 9.55e-01
Molecules associated with elastic fibres 26 7.15e-01 0.041300 9.08e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 7.76e-01 -0.041100 9.30e-01
Signaling by ERBB2 TMD/JMD mutants 17 7.70e-01 -0.041000 9.30e-01
PI-3K cascade:FGFR4 11 8.14e-01 0.040900 9.39e-01
Selective autophagy 77 5.35e-01 0.040900 8.37e-01
Interleukin-17 signaling 68 5.60e-01 0.040800 8.46e-01
Glycerophospholipid biosynthesis 105 4.71e-01 0.040700 8.14e-01
Josephin domain DUBs 10 8.24e-01 -0.040600 9.44e-01
TNFR1-induced NF-kappa-B signaling pathway 32 6.91e-01 -0.040600 9.03e-01
Branched-chain amino acid catabolism 21 7.48e-01 0.040500 9.20e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 7.79e-01 -0.040400 9.30e-01
Phenylalanine and tyrosine metabolism 9 8.35e-01 -0.040000 9.49e-01
Metabolism of lipids 641 8.44e-02 -0.039900 3.07e-01
Metabolism of polyamines 46 6.40e-01 0.039900 8.95e-01
tRNA modification in the nucleus and cytosol 43 6.52e-01 -0.039700 9.01e-01
Downregulation of ERBB2:ERBB3 signaling 12 8.12e-01 -0.039700 9.38e-01
Integration of energy metabolism 88 5.22e-01 -0.039500 8.36e-01
Platelet sensitization by LDL 16 7.85e-01 0.039400 9.30e-01
Signaling by Insulin receptor 63 5.91e-01 0.039100 8.67e-01
NF-kB is activated and signals survival 12 8.15e-01 -0.039100 9.39e-01
Signaling by VEGF 99 5.04e-01 -0.038900 8.35e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 6.16e-01 0.038800 8.79e-01
Glycerophospholipid catabolism 7 8.61e-01 0.038300 9.55e-01
RAC3 GTPase cycle 87 5.38e-01 0.038200 8.37e-01
Regulation of PTEN stability and activity 55 6.24e-01 0.038200 8.86e-01
Activation of Ca-permeable Kainate Receptor 9 8.43e-01 0.038100 9.49e-01
Ionotropic activity of kainate receptors 9 8.43e-01 0.038100 9.49e-01
MAP2K and MAPK activation 36 6.93e-01 0.038000 9.03e-01
Myoclonic epilepsy of Lafora 8 8.52e-01 -0.038000 9.52e-01
Apoptotic cleavage of cellular proteins 35 6.98e-01 -0.037900 9.04e-01
Mitochondrial Uncoupling 6 8.72e-01 -0.037800 9.56e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 7.60e-01 0.037600 9.24e-01
GLI3 is processed to GLI3R by the proteasome 46 6.60e-01 -0.037500 9.01e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 5.50e-01 -0.037500 8.42e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 5.50e-01 -0.037500 8.42e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 5.50e-01 -0.037500 8.42e-01
Macroautophagy 128 4.64e-01 -0.037400 8.13e-01
Interleukin-12 signaling 44 6.68e-01 -0.037300 9.01e-01
Formation of the Editosome 6 8.75e-01 0.037200 9.57e-01
mRNA Editing: C to U Conversion 6 8.75e-01 0.037200 9.57e-01
Voltage gated Potassium channels 27 7.38e-01 0.037200 9.18e-01
Degradation of GLI2 by the proteasome 45 6.68e-01 -0.037000 9.01e-01
Defective pyroptosis 27 7.40e-01 -0.036900 9.19e-01
Glycogen synthesis 11 8.33e-01 0.036800 9.48e-01
MyD88 cascade initiated on plasma membrane 95 5.37e-01 0.036600 8.37e-01
Toll Like Receptor 10 (TLR10) Cascade 95 5.37e-01 0.036600 8.37e-01
Toll Like Receptor 5 (TLR5) Cascade 95 5.37e-01 0.036600 8.37e-01
Urea cycle 7 8.67e-01 0.036400 9.55e-01
TRAIL signaling 8 8.59e-01 -0.036300 9.55e-01
Assembly of active LPL and LIPC lipase complexes 10 8.43e-01 0.036200 9.49e-01
HIV Transcription Initiation 45 6.74e-01 -0.036200 9.01e-01
RNA Polymerase II HIV Promoter Escape 45 6.74e-01 -0.036200 9.01e-01
RNA Polymerase II Promoter Escape 45 6.74e-01 -0.036200 9.01e-01
RNA Polymerase II Transcription Initiation 45 6.74e-01 -0.036200 9.01e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 6.74e-01 -0.036200 9.01e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 6.74e-01 -0.036200 9.01e-01
Downregulation of TGF-beta receptor signaling 26 7.50e-01 -0.036100 9.21e-01
VEGFA-VEGFR2 Pathway 92 5.50e-01 -0.036000 8.42e-01
Peroxisomal lipid metabolism 27 7.47e-01 0.035900 9.20e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 37 7.07e-01 0.035800 9.06e-01
Sema4D induced cell migration and growth-cone collapse 19 7.88e-01 -0.035600 9.31e-01
Formation of ATP by chemiosmotic coupling 20 7.84e-01 -0.035400 9.30e-01
Amyloid fiber formation 51 6.61e-01 0.035400 9.01e-01
TRP channels 22 7.74e-01 -0.035400 9.30e-01
Transcriptional regulation by RUNX2 89 5.64e-01 -0.035400 8.48e-01
Erythropoietin activates STAT5 6 8.81e-01 0.035400 9.58e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 5.76e-01 0.035300 8.57e-01
Diseases of metabolism 204 3.91e-01 -0.034900 7.46e-01
Hyaluronan uptake and degradation 12 8.35e-01 -0.034800 9.49e-01
Complex I biogenesis 66 6.25e-01 0.034800 8.86e-01
Ribavirin ADME 11 8.42e-01 0.034700 9.49e-01
Fatty acyl-CoA biosynthesis 35 7.23e-01 0.034600 9.11e-01
Sulfur amino acid metabolism 22 7.79e-01 0.034500 9.30e-01
Mitochondrial protein degradation 96 5.61e-01 -0.034400 8.46e-01
Rap1 signalling 14 8.24e-01 0.034300 9.44e-01
Cyclin D associated events in G1 47 6.84e-01 -0.034300 9.03e-01
G1 Phase 47 6.84e-01 -0.034300 9.03e-01
Prolactin receptor signaling 11 8.44e-01 -0.034200 9.49e-01
Spry regulation of FGF signaling 16 8.15e-01 0.033800 9.39e-01
GAB1 signalosome 14 8.27e-01 -0.033800 9.45e-01
Complex IV assembly 45 6.95e-01 0.033700 9.04e-01
Diseases of carbohydrate metabolism 29 7.54e-01 0.033600 9.23e-01
Nicotinamide salvaging 16 8.16e-01 0.033500 9.40e-01
Interleukin-10 signaling 39 7.18e-01 0.033500 9.09e-01
Protein-protein interactions at synapses 58 6.61e-01 -0.033300 9.01e-01
Transcriptional regulation of testis differentiation 5 8.98e-01 0.033200 9.59e-01
Lipophagy 7 8.79e-01 -0.033100 9.58e-01
NCAM signaling for neurite out-growth 47 6.96e-01 -0.032900 9.04e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 7.81e-01 0.032900 9.30e-01
ADP signalling through P2Y purinoceptor 12 18 8.10e-01 -0.032700 9.38e-01
Insulin receptor signalling cascade 40 7.22e-01 0.032500 9.11e-01
SMAC (DIABLO) binds to IAPs 7 8.82e-01 0.032400 9.58e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 8.82e-01 0.032400 9.58e-01
SMAC, XIAP-regulated apoptotic response 7 8.82e-01 0.032400 9.58e-01
Negative regulation of the PI3K/AKT network 91 5.94e-01 0.032300 8.71e-01
Signaling by ERBB2 44 7.12e-01 -0.032200 9.07e-01
Proteasome assembly 51 6.91e-01 -0.032100 9.03e-01
The canonical retinoid cycle in rods (twilight vision) 9 8.68e-01 0.032000 9.55e-01
SARS-CoV-2 modulates host translation machinery 49 6.98e-01 0.032000 9.04e-01
Tight junction interactions 17 8.20e-01 0.031800 9.43e-01
Formation of xylulose-5-phosphate 5 9.02e-01 -0.031700 9.62e-01
RHOQ GTPase cycle 54 6.88e-01 -0.031600 9.03e-01
Endogenous sterols 17 8.23e-01 0.031300 9.44e-01
Sensory perception of taste 22 8.00e-01 0.031300 9.33e-01
Gap junction assembly 17 8.25e-01 0.031000 9.44e-01
MAPK1/MAPK3 signaling 231 4.17e-01 -0.031000 7.70e-01
Regulation of expression of SLITs and ROBOs 148 5.16e-01 0.031000 8.36e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 8.42e-01 -0.030800 9.49e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 8.60e-01 -0.030800 9.55e-01
Translesion synthesis by POLI 17 8.27e-01 -0.030700 9.45e-01
VxPx cargo-targeting to cilium 19 8.17e-01 -0.030700 9.40e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 8.97e-01 -0.030600 9.58e-01
TGFBR1 KD Mutants in Cancer 6 8.97e-01 -0.030600 9.58e-01
Cellular response to hypoxia 59 6.86e-01 -0.030400 9.03e-01
Metabolism of cofactors 25 7.94e-01 0.030200 9.33e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 7.53e-01 0.030000 9.22e-01
Phospholipid metabolism 183 4.85e-01 -0.029900 8.28e-01
Signaling by Activin 13 8.53e-01 -0.029700 9.52e-01
ER Quality Control Compartment (ERQC) 21 8.14e-01 0.029700 9.39e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 8.65e-01 -0.029600 9.55e-01
eNOS activation 11 8.65e-01 -0.029600 9.55e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 6.57e-01 -0.029500 9.01e-01
BBSome-mediated cargo-targeting to cilium 23 8.07e-01 -0.029400 9.36e-01
Activation of NMDA receptors and postsynaptic events 74 6.62e-01 0.029400 9.01e-01
Phosphate bond hydrolysis by NTPDase proteins 5 9.10e-01 -0.029400 9.64e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 8.36e-01 0.029000 9.49e-01
Activation of GABAB receptors 30 7.85e-01 -0.028800 9.30e-01
GABA B receptor activation 30 7.85e-01 -0.028800 9.30e-01
Degradation of cysteine and homocysteine 12 8.63e-01 -0.028800 9.55e-01
Extra-nuclear estrogen signaling 65 6.89e-01 0.028700 9.03e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 7.05e-01 -0.028500 9.05e-01
SHC-mediated cascade:FGFR2 13 8.60e-01 0.028200 9.55e-01
Degradation of AXIN 42 7.53e-01 -0.028100 9.22e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 7.29e-01 -0.028100 9.12e-01
Iron uptake and transport 52 7.29e-01 0.027800 9.12e-01
Post-translational protein phosphorylation 67 6.95e-01 0.027700 9.03e-01
IRS-related events triggered by IGF1R 36 7.74e-01 -0.027700 9.30e-01
Mitochondrial protein import 63 7.04e-01 0.027700 9.05e-01
Negative regulation of MAPK pathway 42 7.58e-01 0.027500 9.23e-01
Cargo recognition for clathrin-mediated endocytosis 87 6.59e-01 -0.027300 9.01e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 8.88e-01 0.027100 9.58e-01
Interleukin-4 and Interleukin-13 signaling 92 6.56e-01 0.026900 9.01e-01
Uptake and actions of bacterial toxins 27 8.14e-01 -0.026200 9.39e-01
Signaling by PDGF 48 7.57e-01 -0.025900 9.23e-01
Signaling by MET 68 7.13e-01 0.025800 9.07e-01
Peroxisomal protein import 58 7.35e-01 0.025700 9.17e-01
Asymmetric localization of PCP proteins 49 7.56e-01 -0.025700 9.23e-01
Downregulation of ERBB2 signaling 24 8.28e-01 -0.025600 9.45e-01
RAF/MAP kinase cascade 225 5.08e-01 -0.025600 8.35e-01
Beta-oxidation of very long chain fatty acids 11 8.83e-01 0.025600 9.58e-01
Phase 0 - rapid depolarisation 24 8.29e-01 0.025500 9.45e-01
Class A/1 (Rhodopsin-like receptors) 177 5.58e-01 0.025500 8.46e-01
NCAM1 interactions 26 8.22e-01 0.025400 9.44e-01
Meiotic recombination 37 7.90e-01 -0.025300 9.33e-01
Collagen degradation 42 7.77e-01 0.025300 9.30e-01
Aerobic respiration and respiratory electron transport 245 4.97e-01 -0.025200 8.35e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 7.33e-01 0.025000 9.15e-01
Signalling to ERKs 32 8.07e-01 0.025000 9.36e-01
B-WICH complex positively regulates rRNA expression 45 7.72e-01 0.025000 9.30e-01
Programmed Cell Death 187 5.60e-01 -0.024700 8.46e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 7.87e-01 0.024300 9.31e-01
Signaling by RAS mutants 41 7.87e-01 0.024300 9.31e-01
Signaling by moderate kinase activity BRAF mutants 41 7.87e-01 0.024300 9.31e-01
Signaling downstream of RAS mutants 41 7.87e-01 0.024300 9.31e-01
ER-Phagosome pathway 75 7.16e-01 0.024300 9.08e-01
Synthesis of PIPs at the late endosome membrane 11 8.92e-01 0.023700 9.58e-01
SHC1 events in EGFR signaling 11 8.92e-01 0.023700 9.58e-01
Maternal to zygotic transition (MZT) 72 7.29e-01 -0.023600 9.12e-01
Glycogen metabolism 22 8.48e-01 -0.023600 9.50e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 6.85e-01 0.023500 9.03e-01
Phospholipase C-mediated cascade; FGFR4 6 9.21e-01 -0.023400 9.67e-01
Defensins 8 9.10e-01 -0.023100 9.64e-01
Assembly of collagen fibrils and other multimeric structures 42 7.96e-01 0.023100 9.33e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 8.86e-01 -0.023000 9.58e-01
Phosphorylation of the APC/C 20 8.60e-01 0.022700 9.55e-01
Signaling by ERBB2 KD Mutants 20 8.61e-01 -0.022700 9.55e-01
Platelet activation, signaling and aggregation 221 5.63e-01 0.022600 8.48e-01
Activation of Matrix Metalloproteinases 22 8.55e-01 -0.022500 9.54e-01
Downstream signaling of activated FGFR3 17 8.73e-01 -0.022500 9.56e-01
APC/C-mediated degradation of cell cycle proteins 75 7.37e-01 -0.022400 9.17e-01
Regulation of mitotic cell cycle 75 7.37e-01 -0.022400 9.17e-01
Signaling by ROBO receptors 188 5.98e-01 0.022300 8.72e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 8.63e-01 -0.022300 9.55e-01
Transcriptional regulation by RUNX3 80 7.33e-01 -0.022100 9.15e-01
Transcriptional Regulation by NPAS4 27 8.43e-01 -0.022000 9.49e-01
G1/S DNA Damage Checkpoints 54 7.81e-01 -0.021800 9.30e-01
Miscellaneous transport and binding events 20 8.66e-01 -0.021800 9.55e-01
p75NTR signals via NF-kB 15 8.84e-01 0.021700 9.58e-01
MAPK6/MAPK4 signaling 69 7.56e-01 0.021600 9.23e-01
ABC transporters in lipid homeostasis 14 8.90e-01 -0.021400 9.58e-01
CDC6 association with the ORC:origin complex 8 9.17e-01 0.021300 9.65e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 7.70e-01 0.021300 9.30e-01
RHOH GTPase cycle 33 8.35e-01 0.021000 9.49e-01
MAPK family signaling cascades 263 5.59e-01 -0.021000 8.46e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 8.46e-01 0.020900 9.50e-01
FLT3 signaling by CBL mutants 7 9.24e-01 -0.020800 9.67e-01
Defective GALNT3 causes HFTC 9 9.15e-01 -0.020700 9.65e-01
ABC-family proteins mediated transport 81 7.48e-01 0.020600 9.20e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 7.82e-01 0.020500 9.30e-01
Hedgehog ligand biogenesis 47 8.09e-01 0.020400 9.37e-01
Citric acid cycle (TCA cycle) 34 8.37e-01 -0.020400 9.49e-01
Apoptosis 158 6.59e-01 -0.020400 9.01e-01
Signaling by FGFR1 in disease 32 8.42e-01 -0.020300 9.49e-01
Signaling by Interleukins 390 4.94e-01 -0.020200 8.33e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 9.00e-01 -0.020200 9.61e-01
Induction of Cell-Cell Fusion 8 9.22e-01 0.020100 9.67e-01
HS-GAG degradation 20 8.79e-01 -0.019700 9.58e-01
Toll-like Receptor Cascades 162 6.67e-01 -0.019600 9.01e-01
Apoptotic factor-mediated response 19 8.84e-01 -0.019400 9.58e-01
Regulation of RUNX2 expression and activity 54 8.06e-01 0.019300 9.36e-01
NIK–>noncanonical NF-kB signaling 46 8.21e-01 -0.019300 9.44e-01
Negative epigenetic regulation of rRNA expression 63 7.92e-01 -0.019200 9.33e-01
Interconversion of nucleotide di- and triphosphates 27 8.63e-01 -0.019200 9.55e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 8.02e-01 0.018700 9.34e-01
Ubiquitin-dependent degradation of Cyclin D 39 8.40e-01 0.018700 9.49e-01
RNA Polymerase III Transcription Termination 22 8.80e-01 -0.018700 9.58e-01
RAF-independent MAPK1/3 activation 22 8.80e-01 -0.018500 9.58e-01
Ubiquinol biosynthesis 13 9.08e-01 -0.018500 9.64e-01
Glycogen storage diseases 13 9.08e-01 0.018500 9.64e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 8.19e-01 0.018300 9.42e-01
Ephrin signaling 18 8.93e-01 -0.018300 9.58e-01
Signaling by NTRK1 (TRKA) 102 7.49e-01 0.018300 9.21e-01
Axon guidance 459 5.05e-01 -0.018200 8.35e-01
Formation of the active cofactor, UDP-glucuronate 5 9.44e-01 0.018100 9.79e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 9.14e-01 -0.018000 9.65e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 9.18e-01 -0.017900 9.65e-01
Nicotinate metabolism 27 8.72e-01 0.017800 9.56e-01
Nucleotide-like (purinergic) receptors 14 9.08e-01 -0.017800 9.64e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 9.12e-01 -0.017700 9.64e-01
Nervous system development 478 5.09e-01 -0.017600 8.35e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 8.12e-01 0.017600 9.38e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 9.03e-01 0.017600 9.62e-01
Hh mutants are degraded by ERAD 42 8.44e-01 -0.017500 9.49e-01
Protein localization 157 7.07e-01 -0.017400 9.06e-01
Regulation of FOXO transcriptional activity by acetylation 10 9.24e-01 0.017400 9.67e-01
Condensation of Prophase Chromosomes 27 8.77e-01 -0.017300 9.58e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 8.58e-01 -0.017200 9.55e-01
Caspase activation via Death Receptors in the presence of ligand 16 9.07e-01 -0.016900 9.64e-01
Oxidative Stress Induced Senescence 77 7.99e-01 -0.016800 9.33e-01
Loss of Function of TGFBR1 in Cancer 7 9.39e-01 -0.016800 9.75e-01
Intraflagellar transport 47 8.43e-01 0.016800 9.49e-01
Mucopolysaccharidoses 11 9.24e-01 0.016600 9.67e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 9.15e-01 -0.016500 9.65e-01
ERK/MAPK targets 22 8.95e-01 -0.016300 9.58e-01
Aflatoxin activation and detoxification 14 9.17e-01 -0.016100 9.65e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 8.70e-01 -0.015900 9.56e-01
SHC-mediated cascade:FGFR4 11 9.28e-01 0.015800 9.68e-01
Transport of bile salts and organic acids, metal ions and amine compounds 53 8.42e-01 0.015800 9.49e-01
G-protein beta:gamma signalling 29 8.83e-01 -0.015800 9.58e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 8.22e-01 0.015700 9.44e-01
TP53 Regulates Metabolic Genes 78 8.11e-01 -0.015700 9.38e-01
RHO GTPases activate IQGAPs 25 8.93e-01 0.015500 9.58e-01
RIPK1-mediated regulated necrosis 31 8.82e-01 -0.015400 9.58e-01
Regulation of necroptotic cell death 31 8.82e-01 -0.015400 9.58e-01
p53-Dependent G1 DNA Damage Response 52 8.48e-01 -0.015400 9.50e-01
p53-Dependent G1/S DNA damage checkpoint 52 8.48e-01 -0.015400 9.50e-01
Inactivation of CSF3 (G-CSF) signaling 24 8.97e-01 -0.015300 9.58e-01
MyD88 dependent cascade initiated on endosome 101 7.92e-01 0.015200 9.33e-01
Regulation of insulin secretion 63 8.37e-01 -0.015000 9.49e-01
PI3K Cascade 31 8.86e-01 -0.014900 9.58e-01
EGFR downregulation 26 8.97e-01 0.014700 9.58e-01
Collagen chain trimerization 27 8.96e-01 -0.014600 9.58e-01
SLBP independent Processing of Histone Pre-mRNAs 10 9.37e-01 0.014500 9.73e-01
Elastic fibre formation 33 8.86e-01 0.014400 9.58e-01
RUNX2 regulates bone development 24 9.03e-01 -0.014300 9.62e-01
COPI-independent Golgi-to-ER retrograde traffic 45 8.68e-01 -0.014300 9.55e-01
Visual phototransduction 61 8.49e-01 0.014100 9.50e-01
Signaling by FGFR3 32 8.90e-01 -0.014100 9.58e-01
ADP signalling through P2Y purinoceptor 1 21 9.13e-01 -0.013800 9.65e-01
FRS-mediated FGFR2 signaling 15 9.27e-01 0.013700 9.67e-01
Sphingolipid de novo biosynthesis 35 8.89e-01 -0.013700 9.58e-01
SCF(Skp2)-mediated degradation of p27/p21 50 8.68e-01 -0.013600 9.55e-01
Signaling by NOTCH4 68 8.48e-01 -0.013400 9.50e-01
Netrin-1 signaling 35 8.92e-01 0.013200 9.58e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 8.87e-01 -0.013200 9.58e-01
p53-Independent DNA Damage Response 39 8.87e-01 -0.013200 9.58e-01
p53-Independent G1/S DNA damage checkpoint 39 8.87e-01 -0.013200 9.58e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 9.09e-01 -0.013200 9.64e-01
Listeria monocytogenes entry into host cells 17 9.26e-01 -0.013000 9.67e-01
Signaling by Receptor Tyrosine Kinases 443 6.43e-01 -0.012900 8.97e-01
CLEC7A (Dectin-1) signaling 86 8.37e-01 -0.012800 9.49e-01
TNFs bind their physiological receptors 25 9.12e-01 0.012800 9.64e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 8.92e-01 -0.012700 9.58e-01
Negative regulation of NOTCH4 signaling 44 8.85e-01 -0.012600 9.58e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 9.27e-01 -0.012600 9.67e-01
Downstream signaling events of B Cell Receptor (BCR) 68 8.61e-01 -0.012300 9.55e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 8.91e-01 -0.012300 9.58e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 8.30e-01 0.012100 9.47e-01
Post NMDA receptor activation events 64 8.67e-01 0.012100 9.55e-01
Hh mutants abrogate ligand secretion 43 8.91e-01 -0.012100 9.58e-01
RHOT2 GTPase cycle 7 9.56e-01 -0.012000 9.82e-01
Muscle contraction 145 8.03e-01 -0.012000 9.35e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.17e-01 0.011400 9.65e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 9.04e-01 -0.011300 9.62e-01
Nucleosome assembly 38 9.04e-01 -0.011300 9.62e-01
CDK-mediated phosphorylation and removal of Cdc6 60 8.83e-01 0.011000 9.58e-01
Oncogene Induced Senescence 33 9.15e-01 -0.010700 9.65e-01
P2Y receptors 10 9.56e-01 -0.010200 9.82e-01
Toll Like Receptor 3 (TLR3) Cascade 104 8.58e-01 -0.010100 9.55e-01
Assembly of the pre-replicative complex 87 8.71e-01 -0.010100 9.56e-01
Toll Like Receptor 9 (TLR9) Cascade 108 8.56e-01 -0.010100 9.55e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.61e-01 0.009930 9.85e-01
FOXO-mediated transcription 58 8.97e-01 -0.009870 9.58e-01
Vif-mediated degradation of APOBEC3G 41 9.13e-01 -0.009800 9.65e-01
Transferrin endocytosis and recycling 26 9.33e-01 0.009570 9.70e-01
Lysine catabolism 11 9.57e-01 0.009460 9.82e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 9.17e-01 -0.009290 9.65e-01
EGFR interacts with phospholipase C-gamma 6 9.70e-01 -0.009010 9.88e-01
Maturation of hRSV A proteins 13 9.56e-01 0.008850 9.82e-01
Activation of NF-kappaB in B cells 54 9.12e-01 0.008730 9.64e-01
Digestion 5 9.73e-01 0.008590 9.91e-01
Signaling by FGFR4 32 9.33e-01 -0.008580 9.70e-01
Extracellular matrix organization 219 8.28e-01 -0.008530 9.45e-01
Aquaporin-mediated transport 38 9.30e-01 -0.008220 9.69e-01
Diseases associated with N-glycosylation of proteins 20 9.51e-01 0.008010 9.82e-01
Toll Like Receptor 4 (TLR4) Cascade 138 8.71e-01 0.007990 9.56e-01
MET activates RAS signaling 10 9.65e-01 -0.007960 9.86e-01
Insulin processing 19 9.52e-01 0.007960 9.82e-01
Regulation of FZD by ubiquitination 16 9.56e-01 0.007900 9.82e-01
Inflammasomes 21 9.50e-01 -0.007900 9.82e-01
DNA methylation 18 9.54e-01 0.007850 9.82e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 9.31e-01 -0.007810 9.69e-01
Signaling by ERBB2 in Cancer 21 9.52e-01 -0.007670 9.82e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 9.67e-01 -0.007560 9.87e-01
Defective CFTR causes cystic fibrosis 47 9.29e-01 0.007460 9.69e-01
ABC transporter disorders 60 9.21e-01 0.007450 9.67e-01
Stimuli-sensing channels 80 9.09e-01 -0.007410 9.64e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 9.49e-01 0.007400 9.82e-01
Transmission across Chemical Synapses 183 8.64e-01 -0.007340 9.55e-01
Degradation of the extracellular matrix 96 9.02e-01 0.007310 9.62e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 9.24e-01 -0.007290 9.67e-01
rRNA processing in the nucleus and cytosol 189 8.63e-01 -0.007250 9.55e-01
RSK activation 7 9.74e-01 0.007080 9.91e-01
G alpha (z) signalling events 36 9.42e-01 0.006980 9.77e-01
Regulated proteolysis of p75NTR 11 9.69e-01 0.006770 9.88e-01
Phospholipase C-mediated cascade; FGFR2 8 9.75e-01 0.006450 9.91e-01
Stabilization of p53 43 9.46e-01 0.006010 9.80e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 9.36e-01 0.005840 9.72e-01
Cristae formation 33 9.56e-01 0.005610 9.82e-01
Signaling by BMP 23 9.63e-01 0.005540 9.86e-01
CaMK IV-mediated phosphorylation of CREB 9 9.77e-01 0.005430 9.91e-01
C-type lectin receptors (CLRs) 118 9.19e-01 0.005430 9.65e-01
Carboxyterminal post-translational modifications of tubulin 34 9.58e-01 0.005270 9.83e-01
MyD88-independent TLR4 cascade 108 9.25e-01 -0.005250 9.67e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 9.25e-01 -0.005250 9.67e-01
Mitochondrial iron-sulfur cluster biogenesis 13 9.75e-01 -0.005100 9.91e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 9.65e-01 -0.004980 9.86e-01
Reelin signalling pathway 5 9.85e-01 0.004970 9.92e-01
Erythrocytes take up carbon dioxide and release oxygen 11 9.77e-01 -0.004940 9.91e-01
O2/CO2 exchange in erythrocytes 11 9.77e-01 -0.004940 9.91e-01
Regulation of RUNX3 expression and activity 45 9.56e-01 -0.004770 9.82e-01
Neutrophil degranulation 456 8.64e-01 -0.004670 9.55e-01
O-linked glycosylation of mucins 47 9.56e-01 -0.004650 9.82e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 9.58e-01 -0.004360 9.83e-01
Lewis blood group biosynthesis 13 9.78e-01 0.004350 9.91e-01
Formation of the nephric duct 8 9.83e-01 -0.004350 9.92e-01
RHOBTB1 GTPase cycle 23 9.71e-01 0.004330 9.90e-01
trans-Golgi Network Vesicle Budding 69 9.51e-01 -0.004260 9.82e-01
Signal amplification 28 9.69e-01 0.004240 9.88e-01
Respiratory electron transport 149 9.31e-01 -0.004090 9.69e-01
Signalling to RAS 19 9.78e-01 0.003610 9.91e-01
NoRC negatively regulates rRNA expression 60 9.64e-01 0.003330 9.86e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 9.40e-01 -0.003270 9.75e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.76e-01 0.003210 9.91e-01
Gastrulation 76 9.62e-01 0.003160 9.86e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 9.54e-01 0.003150 9.82e-01
Nonsense-Mediated Decay (NMD) 113 9.54e-01 0.003150 9.82e-01
mTORC1-mediated signalling 24 9.79e-01 -0.003100 9.91e-01
Packaging Of Telomere Ends 18 9.84e-01 -0.002700 9.92e-01
Golgi Associated Vesicle Biogenesis 55 9.73e-01 -0.002620 9.91e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 9.83e-01 0.002540 9.92e-01
Defective Intrinsic Pathway for Apoptosis 24 9.83e-01 0.002510 9.92e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 9.81e-01 0.002320 9.92e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 9.88e-01 -0.002070 9.94e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 9.94e-01 -0.001970 9.95e-01
TAK1-dependent IKK and NF-kappa-B activation 43 9.83e-01 -0.001830 9.92e-01
Transport of vitamins, nucleosides, and related molecules 31 9.87e-01 0.001710 9.94e-01
Tryptophan catabolism 12 9.92e-01 0.001650 9.95e-01
GPCR ligand binding 245 9.65e-01 -0.001650 9.86e-01
Vpu mediated degradation of CD4 39 9.87e-01 0.001550 9.94e-01
Signaling by NTRKs 116 9.78e-01 -0.001460 9.91e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 9.95e-01 0.001310 9.95e-01
IRS-mediated signalling 35 9.90e-01 -0.001220 9.95e-01
Pentose phosphate pathway 13 9.94e-01 0.001210 9.95e-01
FRS-mediated FGFR4 signaling 13 9.95e-01 0.001090 9.95e-01
rRNA processing 213 9.80e-01 -0.000991 9.91e-01
L1CAM interactions 101 9.88e-01 -0.000859 9.94e-01
RAB geranylgeranylation 63 9.92e-01 0.000775 9.95e-01
TNFR2 non-canonical NF-kB pathway 84 9.92e-01 -0.000601 9.95e-01
Neurotransmitter receptors and postsynaptic signal transmission 139 9.93e-01 -0.000423 9.95e-01
Neuronal System 270 9.90e-01 -0.000421 9.95e-01
Translation 292 9.91e-01 -0.000378 9.95e-01


Detailed Gene set reports



Regulation of NFE2L2 gene expression
set Regulation of NFE2L2 gene expression
setSize 8
pANOVA 2.87e-05
s.dist -0.854
p.adjustANOVA 0.000756


Top enriched genes
Top 20 genes
GeneID Gene Rank
NOTCH1 -11070
RELA -10852
NFKB1 -10742
CREBBP -10119
EP300 -9816
MYC -8380
NFE2L2 -8115
MAFK -7045

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH1 -11070
RELA -10852
NFKB1 -10742
CREBBP -10119
EP300 -9816
MYC -8380
NFE2L2 -8115
MAFK -7045


MECP2 regulates transcription of neuronal ligands
set MECP2 regulates transcription of neuronal ligands
setSize 5
pANOVA 0.00335
s.dist -0.757
p.adjustANOVA 0.029


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
HDAC1 -9496
DLL1 -9453
CREB1 -1731

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
HDAC1 -9496
DLL1 -9453
CREB1 -1731


NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
set NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
setSize 7
pANOVA 0.000522
s.dist -0.757
p.adjustANOVA 0.00753


Top enriched genes
Top 20 genes
GeneID Gene Rank
NR1H3 -10509
RXRB -9975
RXRA -9602
NCOR2 -8881
NCOR1 -8487
NCOA1 -7825
NR1H2 -3925

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NR1H3 -10509
RXRB -9975
RXRA -9602
NCOR2 -8881
NCOR1 -8487
NCOA1 -7825
NR1H2 -3925


Phosphorylation of Emi1
set Phosphorylation of Emi1
setSize 6
pANOVA 0.00179
s.dist -0.736
p.adjustANOVA 0.0186


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLK1 -10735
FZR1 -10111
CDK1 -9764
CDC20 -8893
FBXO5 -6961
CCNB1 -2907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLK1 -10735
FZR1 -10111
CDK1 -9764
CDC20 -8893
FBXO5 -6961
CCNB1 -2907


NFE2L2 regulating inflammation associated genes
set NFE2L2 regulating inflammation associated genes
setSize 5
pANOVA 0.00468
s.dist -0.73
p.adjustANOVA 0.0377


Top enriched genes
Top 20 genes
GeneID Gene Rank
CREBBP -10119
EP300 -9816
NFE2L2 -8115
MAFK -7045
CCL2 -5732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CREBBP -10119
EP300 -9816
NFE2L2 -8115
MAFK -7045
CCL2 -5732


Interleukin-21 signaling
set Interleukin-21 signaling
setSize 9
pANOVA 0.000226
s.dist -0.71
p.adjustANOVA 0.00421


Top enriched genes
Top 20 genes
GeneID Gene Rank
IL21R -10698
JAK3 -10370
STAT3 -10341
STAT5A -9868
JAK1 -9480
IL2RG -7471
STAT4 -6110
STAT5B -5731
STAT1 -1405

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL21R -10698
JAK3 -10370
STAT3 -10341
STAT5A -9868
JAK1 -9480
IL2RG -7471
STAT4 -6110
STAT5B -5731
STAT1 -1405


Loss of MECP2 binding ability to the NCoR/SMRT complex
set Loss of MECP2 binding ability to the NCoR/SMRT complex
setSize 7
pANOVA 0.00118
s.dist -0.708
p.adjustANOVA 0.014


Top enriched genes
Top 20 genes
GeneID Gene Rank
MECP2 -10795
GPS2 -10591
NCOR2 -8881
NCOR1 -8487
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MECP2 -10795
GPS2 -10591
NCOR2 -8881
NCOR1 -8487
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189


NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
set NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
setSize 5
pANOVA 0.00693
s.dist -0.697
p.adjustANOVA 0.0505


Top enriched genes
Top 20 genes
GeneID Gene Rank
NR1H3 -10509
RXRB -9975
RXRA -9602
PLIN1 -5013
NR1H2 -3925

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NR1H3 -10509
RXRB -9975
RXRA -9602
PLIN1 -5013
NR1H2 -3925


CYP2E1 reactions
set CYP2E1 reactions
setSize 5
pANOVA 0.00836
s.dist -0.681
p.adjustANOVA 0.0597


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP2D6 -9675
CYP2A6 -9108
CYP2E1 -8930
CYP2S1 -8225
CYP2C8 -2191

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP2D6 -9675
CYP2A6 -9108
CYP2E1 -8930
CYP2S1 -8225
CYP2C8 -2191


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.00117
s.dist -0.663
p.adjustANOVA 0.014


Top enriched genes
Top 20 genes
GeneID Gene Rank
FEN1 -10995
ADPRS -10296
PARP1 -9895
LIG1 -6457
PARG -6383
PARP2 -6014
POLB -4708
APEX1 -4655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FEN1 -10995
ADPRS -10296
PARP1 -9895
LIG1 -6457
PARG -6383
PARP2 -6014
POLB -4708
APEX1 -4655


Eicosanoids
set Eicosanoids
setSize 8
pANOVA 0.00186
s.dist 0.635
p.adjustANOVA 0.019


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP4F8 9249
TBXAS1 8737
CYP4F3 8257
CYP4F11 7315
PTGIS 6918
CYP4F22 5786
CYP4F12 3998
CYP4F2 3847

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F8 9249
TBXAS1 8737
CYP4F3 8257
CYP4F11 7315
PTGIS 6918
CYP4F22 5786
CYP4F12 3998
CYP4F2 3847


Diseases of Base Excision Repair
set Diseases of Base Excision Repair
setSize 5
pANOVA 0.0158
s.dist -0.623
p.adjustANOVA 0.1


Top enriched genes
Top 20 genes
GeneID Gene Rank
NEIL1 -9112
NEIL3 -7898
NTHL1 -7024
MUTYH -5579
OGG1 -5354

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEIL1 -9112
NEIL3 -7898
NTHL1 -7024
MUTYH -5579
OGG1 -5354


Disorders of Developmental Biology
set Disorders of Developmental Biology
setSize 12
pANOVA 0.000204
s.dist -0.619
p.adjustANOVA 0.00392


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503


Disorders of Nervous System Development
set Disorders of Nervous System Development
setSize 12
pANOVA 0.000204
s.dist -0.619
p.adjustANOVA 0.00392


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503


Loss of function of MECP2 in Rett syndrome
set Loss of function of MECP2 in Rett syndrome
setSize 12
pANOVA 0.000204
s.dist -0.619
p.adjustANOVA 0.00392


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503


Pervasive developmental disorders
set Pervasive developmental disorders
setSize 12
pANOVA 0.000204
s.dist -0.619
p.adjustANOVA 0.00392


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10835
MECP2 -10795
GPS2 -10591
HDAC1 -9496
NCOR2 -8881
NCOR1 -8487
PRKACA -7561
TBL1X -7097
HDAC3 -6398
TBL1XR1 -3189
CAMK4 -2556
CALM1 2503


Defective LFNG causes SCDO3
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0191
s.dist -0.605
p.adjustANOVA 0.114


Top enriched genes
Top 20 genes
GeneID Gene Rank
NOTCH1 -11070
LFNG -10002
NOTCH4 -7230
NOTCH3 -4331
NOTCH2 -1354

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH1 -11070
LFNG -10002
NOTCH4 -7230
NOTCH3 -4331
NOTCH2 -1354


NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
set NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
setSize 8
pANOVA 0.00341
s.dist -0.598
p.adjustANOVA 0.0293


Top enriched genes
Top 20 genes
GeneID Gene Rank
NR1H3 -10509
SREBF1 -10459
FASN -10130
RXRB -9975
RXRA -9602
NR1H2 -3925
SCD 219
NRIP1 660

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NR1H3 -10509
SREBF1 -10459
FASN -10130
RXRB -9975
RXRA -9602
NR1H2 -3925
SCD 219
NRIP1 660


Type I hemidesmosome assembly
set Type I hemidesmosome assembly
setSize 8
pANOVA 0.00342
s.dist -0.598
p.adjustANOVA 0.0293


Top enriched genes
Top 20 genes
GeneID Gene Rank
KRT5 -10876
LAMB3 -9866
DST -9597
PLEC -8509
ITGB4 -7516
ITGA6 -5987
COL17A1 -5219
CD151 3855

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KRT5 -10876
LAMB3 -9866
DST -9597
PLEC -8509
ITGB4 -7516
ITGA6 -5987
COL17A1 -5219
CD151 3855


Acetylcholine binding and downstream events
set Acetylcholine binding and downstream events
setSize 5
pANOVA 0.0213
s.dist -0.595
p.adjustANOVA 0.123


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHRNB2 -11051
CHRNE -8942
CHRNA2 -8600
CHRNA5 -2904
CHRNA7 -1912

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHRNB2 -11051
CHRNE -8942
CHRNA2 -8600
CHRNA5 -2904
CHRNA7 -1912


Postsynaptic nicotinic acetylcholine receptors
set Postsynaptic nicotinic acetylcholine receptors
setSize 5
pANOVA 0.0213
s.dist -0.595
p.adjustANOVA 0.123


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHRNB2 -11051
CHRNE -8942
CHRNA2 -8600
CHRNA5 -2904
CHRNA7 -1912

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHRNB2 -11051
CHRNE -8942
CHRNA2 -8600
CHRNA5 -2904
CHRNA7 -1912


NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
set NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
setSize 32
pANOVA 2.07e-08
s.dist -0.572
p.adjustANOVA 1.66e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
KDM4A -10837
GPS2 -10591
ABCG8 -10569
NR1H3 -10509
RXRB -9975
EP300 -9816
ABCA1 -9715
RXRA -9602
MOV10 -9589
TNRC6A -9497
NCOR2 -8881
APOE -8774
KDM3A -8731
TNRC6C -8594
NCOR1 -8487
ABCG1 -7936
NCOA1 -7825
ARL4C -7288
KDM1A -7207
TBL1X -7097

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KDM4A -10837
GPS2 -10591
ABCG8 -10569
NR1H3 -10509
RXRB -9975
EP300 -9816
ABCA1 -9715
RXRA -9602
MOV10 -9589
TNRC6A -9497
NCOR2 -8881
APOE -8774
KDM3A -8731
TNRC6C -8594
NCOR1 -8487
ABCG1 -7936
NCOA1 -7825
ARL4C -7288
KDM1A -7207
TBL1X -7097
AGO2 -6988
HDAC3 -6398
EEPD1 -4903
PLTP -4588
NR1H2 -3925
AGO1 -3473
TBL1XR1 -3189
CETP -2915
TNRC6B -1208
AGO3 2137
KDM1B 3909
AGO4 7257


Interleukin-9 signaling
set Interleukin-9 signaling
setSize 8
pANOVA 0.00608
s.dist -0.56
p.adjustANOVA 0.0456


Top enriched genes
Top 20 genes
GeneID Gene Rank
JAK3 -10370
STAT3 -10341
STAT5A -9868
JAK1 -9480
IL2RG -7471
STAT5B -5731
STAT1 -1405
IL9R 4234

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JAK3 -10370
STAT3 -10341
STAT5A -9868
JAK1 -9480
IL2RG -7471
STAT5B -5731
STAT1 -1405
IL9R 4234


Biosynthesis of EPA-derived SPMs
set Biosynthesis of EPA-derived SPMs
setSize 6
pANOVA 0.0184
s.dist 0.556
p.adjustANOVA 0.112


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTGS2 10740
HPGD 8949
ALOX5 8673
LTA4H 8196
GPX4 763
ALOX15 -1969

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All member genes
GeneID Gene Rank
PTGS2 10740
HPGD 8949
ALOX5 8673
LTA4H 8196
GPX4 763
ALOX15 -1969


DEx/H-box helicases activate type I IFN and inflammatory cytokines production
set DEx/H-box helicases activate type I IFN and inflammatory cytokines production
setSize 7
pANOVA 0.0112
s.dist -0.554
p.adjustANOVA 0.0759


Top enriched genes
Top 20 genes
GeneID Gene Rank
RELA -10852
NFKB1 -10742
NFKB2 -9145
IRF7 -9036
MYD88 -7183
DHX9 -3926
DHX36 7248

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELA -10852
NFKB1 -10742
NFKB2 -9145
IRF7 -9036
MYD88 -7183
DHX9 -3926
DHX36 7248


Processive synthesis on the C-strand of the telomere
set Processive synthesis on the C-strand of the telomere
setSize 19
pANOVA 5.32e-05
s.dist -0.535
p.adjustANOVA 0.00133


Top enriched genes
Top 20 genes
GeneID Gene Rank
FEN1 -10995
TERF2 -10550
WRN -9964
DNA2 -9892
PCNA -7482
POLD1 -7272
TINF2 -7174
RPA3 -6996
RPA1 -6780
LIG1 -6457
BLM -6378
ACD -5783
POLD4 -4520
POT1 -4422
POLD2 -3757
RPA2 -3463
TERF2IP -1763
TERF1 -629
POLD3 -314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FEN1 -10995
TERF2 -10550
WRN -9964
DNA2 -9892
PCNA -7482
POLD1 -7272
TINF2 -7174
RPA3 -6996
RPA1 -6780
LIG1 -6457
BLM -6378
ACD -5783
POLD4 -4520
POT1 -4422
POLD2 -3757
RPA2 -3463
TERF2IP -1763
TERF1 -629
POLD3 -314


Activation of PUMA and translocation to mitochondria
set Activation of PUMA and translocation to mitochondria
setSize 9
pANOVA 0.00566
s.dist -0.533
p.adjustANOVA 0.0428


Top enriched genes
Top 20 genes
GeneID Gene Rank
TP53 -10450
TP73 -9904
TFDP1 -9447
TFDP2 -8821
PPP1R13B -7986
BBC3 -5953
E2F1 -5202
TP63 338
TP53BP2 3401

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TP53 -10450
TP73 -9904
TFDP1 -9447
TFDP2 -8821
PPP1R13B -7986
BBC3 -5953
E2F1 -5202
TP63 338
TP53BP2 3401


Removal of the Flap Intermediate from the C-strand
set Removal of the Flap Intermediate from the C-strand
setSize 17
pANOVA 0.000149
s.dist -0.531
p.adjustANOVA 0.00314


Top enriched genes
Top 20 genes
GeneID Gene Rank
FEN1 -10995
TERF2 -10550
WRN -9964
DNA2 -9892
PCNA -7482
POLD1 -7272
TINF2 -7174
RPA3 -6996
RPA1 -6780
ACD -5783
POLD4 -4520
POT1 -4422
POLD2 -3757
RPA2 -3463
TERF2IP -1763
TERF1 -629
POLD3 -314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FEN1 -10995
TERF2 -10550
WRN -9964
DNA2 -9892
PCNA -7482
POLD1 -7272
TINF2 -7174
RPA3 -6996
RPA1 -6780
ACD -5783
POLD4 -4520
POT1 -4422
POLD2 -3757
RPA2 -3463
TERF2IP -1763
TERF1 -629
POLD3 -314


Cross-presentation of particulate exogenous antigens (phagosomes)
set Cross-presentation of particulate exogenous antigens (phagosomes)
setSize 8
pANOVA 0.00973
s.dist 0.528
p.adjustANOVA 0.0667


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCF1 9575
CD36 9442
ITGAV 8361
CYBB 8033
NCF2 5344
NCF4 4797
ITGB5 4577
CYBA -5427

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCF1 9575
CD36 9442
ITGAV 8361
CYBB 8033
NCF2 5344
NCF4 4797
ITGB5 4577
CYBA -5427


APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
set APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
setSize 7
pANOVA 0.0157
s.dist -0.527
p.adjustANOVA 0.0994


Top enriched genes
Top 20 genes
GeneID Gene Rank
NEIL1 -9112
LIG3 -7315
PNKP -6790
XRCC1 -5562
OGG1 -5354
POLB -4708
NEIL2 -2784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEIL1 -9112
LIG3 -7315
PNKP -6790
XRCC1 -5562
OGG1 -5354
POLB -4708
NEIL2 -2784


Interleukin-2 signaling
set Interleukin-2 signaling
setSize 11
pANOVA 0.00249
s.dist -0.527
p.adjustANOVA 0.0234


Top enriched genes
Top 20 genes
GeneID Gene Rank
IL2RB -11059
JAK3 -10370
STAT5A -9868
JAK1 -9480
SHC1 -8675
LCK -7989
IL2RG -7471
PTK2B -6964
STAT5B -5731
SYK 3874
IL2RA 8430

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL2RB -11059
JAK3 -10370
STAT5A -9868
JAK1 -9480
SHC1 -8675
LCK -7989
IL2RG -7471
PTK2B -6964
STAT5B -5731
SYK 3874
IL2RA 8430


Unwinding of DNA
set Unwinding of DNA
setSize 12
pANOVA 0.00174
s.dist -0.522
p.adjustANOVA 0.0184


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCM3 -10931
MCM4 -10079
MCM2 -9382
MCM5 -9311
MCM7 -9117
CDC45 -8729
GINS4 -6434
MCM8 -5493
GINS2 -4178
MCM6 -3741
GINS1 -549
GINS3 7317

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -10931
MCM4 -10079
MCM2 -9382
MCM5 -9311
MCM7 -9117
CDC45 -8729
GINS4 -6434
MCM8 -5493
GINS2 -4178
MCM6 -3741
GINS1 -549
GINS3 7317


Scavenging by Class F Receptors
set Scavenging by Class F Receptors
setSize 5
pANOVA 0.0443
s.dist -0.519
p.adjustANOVA 0.202


Top enriched genes
Top 20 genes
GeneID Gene Rank
HYOU1 -10889
HSPH1 -9055
CALR -7655
HSP90AA1 -2295
SCARF1 592

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HYOU1 -10889
HSPH1 -9055
CALR -7655
HSP90AA1 -2295
SCARF1 592


NR1H2 and NR1H3-mediated signaling
set NR1H2 and NR1H3-mediated signaling
setSize 38
pANOVA 3.36e-08
s.dist -0.517
p.adjustANOVA 2.4e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
KDM4A -10837
GPS2 -10591
ABCG8 -10569
NR1H3 -10509
SREBF1 -10459
FASN -10130
RXRB -9975
EP300 -9816
ABCA1 -9715
RXRA -9602
MOV10 -9589
TNRC6A -9497
NCOR2 -8881
APOE -8774
KDM3A -8731
TNRC6C -8594
NCOR1 -8487
ABCG1 -7936
NCOA1 -7825
ARL4C -7288

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KDM4A -10837
GPS2 -10591
ABCG8 -10569
NR1H3 -10509
SREBF1 -10459
FASN -10130
RXRB -9975
EP300 -9816
ABCA1 -9715
RXRA -9602
MOV10 -9589
TNRC6A -9497
NCOR2 -8881
APOE -8774
KDM3A -8731
TNRC6C -8594
NCOR1 -8487
ABCG1 -7936
NCOA1 -7825
ARL4C -7288
KDM1A -7207
TBL1X -7097
AGO2 -6988
HDAC3 -6398
PLIN1 -5013
EEPD1 -4903
PLTP -4588
NR1H2 -3925
AGO1 -3473
TBL1XR1 -3189
CETP -2915
TNRC6B -1208
SCD 219
NRIP1 660
AGO3 2137
KDM1B 3909
AGO4 7257
MYLIP 9000


Formation of the ureteric bud
set Formation of the ureteric bud
setSize 5
pANOVA 0.0463
s.dist 0.515
p.adjustANOVA 0.208


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGB1 9804
GREM1 9361
FOXC1 7157
RET 3878
WNT11 -2979

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGB1 9804
GREM1 9361
FOXC1 7157
RET 3878
WNT11 -2979


Passive transport by Aquaporins
set Passive transport by Aquaporins
setSize 6
pANOVA 0.0321
s.dist 0.505
p.adjustANOVA 0.165


Top enriched genes
Top 20 genes
GeneID Gene Rank
AQP1 9931
AQP10 8326
AQP11 7665
AQP9 7377
AQP7 5831
AQP3 -7081

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AQP1 9931
AQP10 8326
AQP11 7665
AQP9 7377
AQP7 5831
AQP3 -7081


NFE2L2 regulating MDR associated enzymes
set NFE2L2 regulating MDR associated enzymes
setSize 8
pANOVA 0.0154
s.dist -0.495
p.adjustANOVA 0.0993


Top enriched genes
Top 20 genes
GeneID Gene Rank
CREBBP -10119
EP300 -9816
NFE2L2 -8115
ABCC1 -7577
MAFK -7045
ABCF2 -3419
ABCG2 -1258
ABCC3 2648

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CREBBP -10119
EP300 -9816
NFE2L2 -8115
ABCC1 -7577
MAFK -7045
ABCF2 -3419
ABCG2 -1258
ABCC3 2648


HDMs demethylate histones
set HDMs demethylate histones
setSize 22
pANOVA 6.3e-05
s.dist -0.493
p.adjustANOVA 0.0015


Top enriched genes
Top 20 genes
GeneID Gene Rank
KDM2A -11111.0
PHF2 -10940.0
KDM4A -10837.0
KDM6B -10772.0
PHF8 -10678.0
KDM2B -10542.0
KDM5B -10083.0
KDM5A -9085.0
KDM5C -8759.0
KDM3A -8731.0
JMJD6 -8566.0
KDM3B -8216.0
KDM4B -7789.0
KDM1A -7207.0
UTY -6304.0
KDM5D -2482.0
H3C15 392.5
KDM7A 2295.0
ARID5B 3456.0
KDM1B 3909.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KDM2A -11111.0
PHF2 -10940.0
KDM4A -10837.0
KDM6B -10772.0
PHF8 -10678.0
KDM2B -10542.0
KDM5B -10083.0
KDM5A -9085.0
KDM5C -8759.0
KDM3A -8731.0
JMJD6 -8566.0
KDM3B -8216.0
KDM4B -7789.0
KDM1A -7207.0
UTY -6304.0
KDM5D -2482.0
H3C15 392.5
KDM7A 2295.0
ARID5B 3456.0
KDM1B 3909.0
KDM4C 4800.0
KDM6A 4848.0


STAT3 nuclear events downstream of ALK signaling
set STAT3 nuclear events downstream of ALK signaling
setSize 11
pANOVA 0.00474
s.dist -0.492
p.adjustANOVA 0.0377


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A -10835
DNMT1 -10595
STAT3 -10341
EP300 -9816
HDAC1 -9496
IL2RG -7471
HIF1A -7063
HDAC3 -6398
CD274 -3219
HDAC2 4518
PRDM1 9602

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A -10835
DNMT1 -10595
STAT3 -10341
EP300 -9816
HDAC1 -9496
IL2RG -7471
HIF1A -7063
HDAC3 -6398
CD274 -3219
HDAC2 4518
PRDM1 9602


TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
set TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
setSize 18
pANOVA 0.000307
s.dist -0.491
p.adjustANOVA 0.00531


Top enriched genes
Top 20 genes
GeneID Gene Rank
TP53 -10450
CARM1 -10430
EP300 -9816
CDK1 -9764
TFDP1 -9447
CDC25C -9201
TFDP2 -8821
PCNA -7482
BAX -5471
AURKA -5384
RBL2 -5142
PRMT1 -5131
E2F4 -5047
CCNB1 -2907
SFN -1044
ZNF385A 455
GADD45A 568
RBL1 4623

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TP53 -10450
CARM1 -10430
EP300 -9816
CDK1 -9764
TFDP1 -9447
CDC25C -9201
TFDP2 -8821
PCNA -7482
BAX -5471
AURKA -5384
RBL2 -5142
PRMT1 -5131
E2F4 -5047
CCNB1 -2907
SFN -1044
ZNF385A 455
GADD45A 568
RBL1 4623


Activation of NIMA Kinases NEK9, NEK6, NEK7
set Activation of NIMA Kinases NEK9, NEK6, NEK7
setSize 7
pANOVA 0.0258
s.dist -0.487
p.adjustANOVA 0.141


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLK1 -10735
CDK1 -9764
CCNB2 -7797
NEK6 -6365
CCNB1 -2907
NEK7 -1193
NEK9 252

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLK1 -10735
CDK1 -9764
CCNB2 -7797
NEK6 -6365
CCNB1 -2907
NEK7 -1193
NEK9 252


TGFBR3 regulates TGF-beta signaling
set TGFBR3 regulates TGF-beta signaling
setSize 8
pANOVA 0.0174
s.dist -0.485
p.adjustANOVA 0.106


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARRB2 -9211
TGFBR3 -8551
TGFB2 -8056
TGFBR1 -7077
ARRB1 -4375
GIPC1 -3309
TGFB1 -1921
TGFBR2 -1408

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARRB2 -9211
TGFBR3 -8551
TGFB2 -8056
TGFBR1 -7077
ARRB1 -4375
GIPC1 -3309
TGFB1 -1921
TGFBR2 -1408


NFE2L2 regulating ER-stress associated genes
set NFE2L2 regulating ER-stress associated genes
setSize 5
pANOVA 0.0601
s.dist -0.485
p.adjustANOVA 0.249


Top enriched genes
Top 20 genes
GeneID Gene Rank
CREBBP -10119
EP300 -9816
NFE2L2 -8115
MAFK -7045
ATF4 7652

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CREBBP -10119
EP300 -9816
NFE2L2 -8115
MAFK -7045
ATF4 7652


Repression of WNT target genes
set Repression of WNT target genes
setSize 14
pANOVA 0.0023
s.dist -0.471
p.adjustANOVA 0.0221


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLE3 -10878
TCF7 -9933
HDAC1 -9496
MYC -8380
LEF1 -7764
CTBP1 -7531
TLE2 -7489
TLE4 -7076
TLE5 -5772
TLE1 -4195
AXIN2 -3075
CTBP2 -1911
TCF7L2 2871
TCF7L1 6089

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLE3 -10878
TCF7 -9933
HDAC1 -9496
MYC -8380
LEF1 -7764
CTBP1 -7531
TLE2 -7489
TLE4 -7076
TLE5 -5772
TLE1 -4195
AXIN2 -3075
CTBP2 -1911
TCF7L2 2871
TCF7L1 6089


Interleukin-23 signaling
set Interleukin-23 signaling
setSize 7
pANOVA 0.0324
s.dist -0.467
p.adjustANOVA 0.166


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAT3 -10341
IL23A -10272
TYK2 -7140
IL12RB1 -6939
STAT4 -6110
P4HB -3109
JAK2 6915

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT3 -10341
IL23A -10272
TYK2 -7140
IL12RB1 -6939
STAT4 -6110
P4HB -3109
JAK2 6915


Biosynthesis of E-series 18(S)-resolvins
set Biosynthesis of E-series 18(S)-resolvins
setSize 5
pANOVA 0.0706
s.dist 0.467
p.adjustANOVA 0.274


Top enriched genes
Top 20 genes
GeneID Gene Rank
HPGD 8949
ALOX5 8673
LTA4H 8196
GPX4 763
ALOX15 -1969

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HPGD 8949
ALOX5 8673
LTA4H 8196
GPX4 763
ALOX15 -1969


HDR through MMEJ (alt-NHEJ)
set HDR through MMEJ (alt-NHEJ)
setSize 12
pANOVA 0.00518
s.dist -0.466
p.adjustANOVA 0.0401


Top enriched genes
Top 20 genes
GeneID Gene Rank
FEN1 -10995
RAD52 -9995
PARP1 -9895
POLQ -9359
LIG3 -7315
PARP2 -6014
XRCC1 -5562
BRCA2 -4239
RAD50 -2871
RBBP8 280
NBN 1028
MRE11 1635

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FEN1 -10995
RAD52 -9995
PARP1 -9895
POLQ -9359
LIG3 -7315
PARP2 -6014
XRCC1 -5562
BRCA2 -4239
RAD50 -2871
RBBP8 280
NBN 1028
MRE11 1635


Regulation of TP53 Activity through Acetylation
set Regulation of TP53 Activity through Acetylation
setSize 29
pANOVA 1.54e-05
s.dist -0.464
p.adjustANOVA 0.000488


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHD4 -11100
GATAD2A -11026
CHD3 -10906
BRPF1 -10802
TP53 -10450
GATAD2B -10267
MTA2 -10147
BRPF3 -9955
EP300 -9816
BRD1 -9621
HDAC1 -9496
AKT2 -9420
AKT1 -8950
KAT6A -8866
PML -8516
PIP4K2B -7372
MBD3 -6595
RBBP7 -6333
ING5 -5774
BRD7 -5033

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHD4 -11100
GATAD2A -11026
CHD3 -10906
BRPF1 -10802
TP53 -10450
GATAD2B -10267
MTA2 -10147
BRPF3 -9955
EP300 -9816
BRD1 -9621
HDAC1 -9496
AKT2 -9420
AKT1 -8950
KAT6A -8866
PML -8516
PIP4K2B -7372
MBD3 -6595
RBBP7 -6333
ING5 -5774
BRD7 -5033
PIN1 -1957
PIP4K2C -1800
RBBP4 -1506
PIP4K2A 3609
MEAF6 4447
HDAC2 4518
MAP2K6 5791
ING2 6807
AKT3 8443


Nef and signal transduction
set Nef and signal transduction
setSize 8
pANOVA 0.0237
s.dist -0.462
p.adjustANOVA 0.132


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD247 -10443
ELMO1 -10235
LCK -7989
HCK -7176
DOCK2 -6204
RAC1 -2798
FYN -941
PAK2 3945

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD247 -10443
ELMO1 -10235
LCK -7989
HCK -7176
DOCK2 -6204
RAC1 -2798
FYN -941
PAK2 3945


HDL remodeling
set HDL remodeling
setSize 6
pANOVA 0.0511
s.dist -0.46
p.adjustANOVA 0.226


Top enriched genes
Top 20 genes
GeneID Gene Rank
APOE -8774
ABCG1 -7936
LCAT -6581
PLTP -4588
CETP -2915
LIPG -451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOE -8774
ABCG1 -7936
LCAT -6581
PLTP -4588
CETP -2915
LIPG -451


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## [[1]]
## [[1]]$`UP genesets.Arachidonate metabolism`
## [1] "ALOX15B" "PTGS2"  
## 
## [[1]]$`UP genesets.Eicosanoids`
## character(0)
## 
## [[1]]$`UP genesets.Expression and translocation of olfactory receptors`
## [1] "OR1D2"  "OR2AT4" "OR2C3"  "OR2M3" 
## 
## [[1]]$`UP genesets.Olfactory Signaling Pathway`
## [1] "OR1D2"  "OR2AT4" "OR2C3"  "OR2M3" 
## 
## [[1]]$`UP genesets.Response of EIF2AK1 (HRI) to heme deficiency`
## [1] "ATF3"     "PPP1R15A"
## 
## [[1]]$`DOWN genesets.Activation of PUMA and translocation to mitochondria`
## [1] "BBC3"     "E2F1"     "PPP1R13B" "TFDP1"    "TFDP2"    "TP53"     "TP53BP2" 
## [8] "TP63"     "TP73"    
## 
## [[1]]$`DOWN genesets.Disorders of Developmental Biology`
##  [1] "CALM1"   "CAMK4"   "GPS2"    "HDAC1"   "HDAC3"   "MECP2"   "NCOR1"  
##  [8] "NCOR2"   "PRKACA"  "SIN3A"   "TBL1X"   "TBL1XR1"
## 
## [[1]]$`DOWN genesets.Disorders of Nervous System Development`
##  [1] "CALM1"   "CAMK4"   "GPS2"    "HDAC1"   "HDAC3"   "MECP2"   "NCOR1"  
##  [8] "NCOR2"   "PRKACA"  "SIN3A"   "TBL1X"   "TBL1XR1"
## 
## [[1]]$`DOWN genesets.Interleukin-2 signaling`
##  [1] "IL2RA"  "IL2RB"  "IL2RG"  "JAK1"   "JAK3"   "LCK"    "PTK2B"  "SHC1"  
##  [9] "STAT5A" "STAT5B" "SYK"   
## 
## [[1]]$`DOWN genesets.Interleukin-21 signaling`
## [1] "IL21R"  "IL2RG"  "JAK1"   "JAK3"   "STAT1"  "STAT3"  "STAT4"  "STAT5A"
## [9] "STAT5B"
## 
## [[1]]$`DOWN genesets.Interleukin-9 signaling`
## [1] "IL2RG"  "IL9R"   "JAK1"   "JAK3"   "STAT1"  "STAT3"  "STAT5A" "STAT5B"
## 
## [[1]]$`DOWN genesets.Loss of MECP2 binding ability to the NCoR/SMRT complex`
## [1] "GPS2"    "HDAC3"   "MECP2"   "NCOR1"   "NCOR2"   "TBL1X"   "TBL1XR1"
## 
## [[1]]$`DOWN genesets.Loss of function of MECP2 in Rett syndrome`
##  [1] "CALM1"   "CAMK4"   "GPS2"    "HDAC1"   "HDAC3"   "MECP2"   "NCOR1"  
##  [8] "NCOR2"   "PRKACA"  "SIN3A"   "TBL1X"   "TBL1XR1"
## 
## [[1]]$`DOWN genesets.MECP2 regulates transcription of neuronal ligands`
## [1] "CREB1" "DLL1"  "HDAC1" "MECP2" "SIN3A"
## 
## [[1]]$`DOWN genesets.NFE2L2 regulating inflammation associated genes`
## [1] "CCL2"   "CREBBP" "EP300"  "MAFK"   "NFE2L2"
## 
## [[1]]$`DOWN genesets.NR1H2 & NR1H3 regulate gene expression linked to lipogenesis`
## [1] "FASN"   "NR1H2"  "NR1H3"  "NRIP1"  "RXRA"   "RXRB"   "SCD"    "SREBF1"
## 
## [[1]]$`DOWN genesets.NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis`
## [1] "NCOA1" "NCOR1" "NCOR2" "NR1H2" "NR1H3" "RXRA"  "RXRB" 
## 
## [[1]]$`DOWN genesets.NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux`
##  [1] "ABCA1"   "ABCG1"   "ABCG8"   "AGO1"    "AGO2"    "AGO3"    "AGO4"   
##  [8] "APOE"    "ARL4C"   "CETP"    "EEPD1"   "EP300"   "GPS2"    "HDAC3"  
## [15] "KDM1A"   "KDM1B"   "KDM3A"   "KDM4A"   "MOV10"   "NCOA1"   "NCOR1"  
## [22] "NCOR2"   "NR1H2"   "NR1H3"   "PLTP"    "RXRA"    "RXRB"    "TBL1X"  
## [29] "TBL1XR1" "TNRC6A"  "TNRC6B"  "TNRC6C" 
## 
## [[1]]$`DOWN genesets.POLB-Dependent Long Patch Base Excision Repair`
## [1] "ADPRS" "APEX1" "FEN1"  "LIG1"  "PARG"  "PARP1" "PARP2" "POLB" 
## 
## [[1]]$`DOWN genesets.Pervasive developmental disorders`
##  [1] "CALM1"   "CAMK4"   "GPS2"    "HDAC1"   "HDAC3"   "MECP2"   "NCOR1"  
##  [8] "NCOR2"   "PRKACA"  "SIN3A"   "TBL1X"   "TBL1XR1"
## 
## [[1]]$`DOWN genesets.Phosphorylation of Emi1`
## [1] "CCNB1" "CDC20" "CDK1"  "FBXO5" "FZR1"  "PLK1" 
## 
## [[1]]$`DOWN genesets.Processive synthesis on the C-strand of the telomere`
##  [1] "ACD"     "BLM"     "DNA2"    "FEN1"    "LIG1"    "PCNA"    "POLD1"  
##  [8] "POLD2"   "POLD3"   "POLD4"   "POT1"    "RPA1"    "RPA2"    "RPA3"   
## [15] "TERF1"   "TERF2"   "TERF2IP" "TINF2"   "WRN"    
## 
## [[1]]$`DOWN genesets.Regulation of NFE2L2 gene expression`
## [1] "CREBBP" "EP300"  "MAFK"   "MYC"    "NFE2L2" "NFKB1"  "NOTCH1" "RELA"  
## 
## [[1]]$`DOWN genesets.Removal of the Flap Intermediate from the C-strand`
##  [1] "ACD"     "DNA2"    "FEN1"    "PCNA"    "POLD1"   "POLD2"   "POLD3"  
##  [8] "POLD4"   "POT1"    "RPA1"    "RPA2"    "RPA3"    "TERF1"   "TERF2"  
## [15] "TERF2IP" "TINF2"   "WRN"    
## 
## [[1]]$`DOWN genesets.Type I hemidesmosome assembly`
## [1] "CD151"   "COL17A1" "DST"     "ITGA6"   "ITGB4"   "KRT5"    "LAMB3"  
## [8] "PLEC"

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] RhpcBLASctl_0.23-42         gtools_3.9.5               
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] ggplot2_4.0.3               kableExtra_1.4.0           
##  [7] beeswarm_0.4.0              eulerr_7.1.0               
##  [9] MASS_7.3-65                 mitch_1.22.1               
## [11] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [13] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [15] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [17] Seqinfo_1.0.0               IRanges_2.44.0             
## [19] S4Vectors_0.48.1            BiocGenerics_0.56.0        
## [21] generics_0.1.4              dplyr_1.2.1                
## [23] WGCNA_1.74                  fastcluster_1.3.0          
## [25] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [27] gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] crosstalk_1.2.2       Hmisc_5.2-5           labeling_0.4.3       
##  [37] polyclip_1.10-7       abind_1.4-8           compiler_4.5.2       
##  [40] withr_3.0.2           doParallel_1.0.17     htmlTable_2.5.0      
##  [43] S7_0.2.2              backports_1.5.1       BiocParallel_1.44.0  
##  [46] ggstats_0.13.0        DelayedArray_0.36.1   caTools_1.18.3       
##  [49] tools_4.5.2           foreign_0.8-90        otel_0.2.0           
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.2.1   xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report