date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 0.1120347
A1BG 0.0355416
A1BG-AS1 -0.2045265
A1CF -0.4927781
A2M -3.2175052
A2M-AS1 -2.8044510

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
RUNX1 regulates transcription of genes involved in BCR signaling 6 9.98e-04 -0.776 2.57e-02
CD163 mediating an anti-inflammatory response 9 7.12e-05 -0.764 5.14e-03
Formation of xylulose-5-phosphate 5 6.85e-03 0.698 8.31e-02
Defective LFNG causes SCDO3 5 8.30e-03 0.682 9.11e-02
Fructose metabolism 7 1.81e-03 0.681 3.71e-02
Formation of the ureteric bud 5 1.09e-02 -0.658 1.07e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.30e-03 0.656 2.93e-02
LTC4-CYSLTR mediated IL4 production 5 1.23e-02 0.647 1.16e-01
Fructose catabolism 5 1.75e-02 0.614 1.46e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.83e-03 -0.602 7.62e-02
MECP2 regulates transcription of neuronal ligands 5 2.00e-02 0.601 1.56e-01
Defects in biotin (Btn) metabolism 8 4.16e-03 0.585 6.31e-02
Alternative complement activation 5 2.38e-02 0.584 1.71e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 9.75e-03 0.564 9.97e-02
Phenylalanine metabolism 5 3.07e-02 0.558 1.98e-01
MET activates RAP1 and RAC1 10 2.50e-03 -0.552 4.59e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 2.65e-03 -0.549 4.78e-02
MET activates PI3K/AKT signaling 5 3.62e-02 -0.541 2.16e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.33e-02 0.540 1.21e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.57e-02 -0.526 1.79e-01
Reversible hydration of carbon dioxide 8 1.00e-02 -0.526 1.01e-01
Propionyl-CoA catabolism 5 4.44e-02 0.519 2.42e-01
Synthesis of PG 8 1.16e-02 0.515 1.11e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 4.65e-02 0.514 2.50e-01
Sulfide oxidation to sulfate 5 4.66e-02 0.514 2.50e-01
Defective binding of VWF variant to GPIb:IX:V 7 1.90e-02 -0.512 1.54e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.90e-02 -0.512 1.54e-01
PTK6 Regulates Cell Cycle 6 3.44e-02 0.499 2.10e-01
Activation of NOXA and translocation to mitochondria 5 5.67e-02 0.492 2.74e-01
Molybdenum cofactor biosynthesis 6 3.85e-02 0.488 2.25e-01
IFNG signaling activates MAPKs 8 1.74e-02 -0.486 1.46e-01
Carnitine shuttle 12 3.65e-03 0.485 5.98e-02
Unwinding of DNA 12 3.73e-03 0.483 6.00e-02
Type I hemidesmosome assembly 8 1.85e-02 0.481 1.52e-01
Signal attenuation 9 1.25e-02 -0.481 1.17e-01
Creation of C4 and C2 activators 71 2.71e-12 0.480 2.62e-09
Initial triggering of complement 79 2.97e-13 0.475 5.73e-10
Translocation of ZAP-70 to Immunological synapse 24 6.15e-05 0.472 4.75e-03
Classical antibody-mediated complement activation 69 1.45e-11 0.470 9.36e-09
Estrogen-stimulated signaling through PRKCZ 6 4.67e-02 -0.469 2.50e-01
POLB-Dependent Long Patch Base Excision Repair 8 2.37e-02 0.462 1.71e-01
Diseases of Base Excision Repair 5 7.49e-02 0.460 3.21e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 3.52e-02 -0.460 2.13e-01
Biotin transport and metabolism 11 8.42e-03 0.459 9.20e-02
Formation of the active cofactor, UDP-glucuronate 5 7.78e-02 -0.455 3.27e-01
Modulation by Mtb of host immune system 7 3.75e-02 -0.454 2.21e-01
Erythrocytes take up carbon dioxide and release oxygen 11 9.29e-03 -0.453 9.71e-02
O2/CO2 exchange in erythrocytes 11 9.29e-03 -0.453 9.71e-02
Phosphorylation of Emi1 6 5.47e-02 0.453 2.67e-01
Organic anion transporters 7 3.88e-02 0.451 2.25e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
RUNX1 regulates transcription of genes involved in BCR signaling 6 9.98e-04 -0.776000 2.57e-02
CD163 mediating an anti-inflammatory response 9 7.12e-05 -0.764000 5.14e-03
Formation of xylulose-5-phosphate 5 6.85e-03 0.698000 8.31e-02
Defective LFNG causes SCDO3 5 8.30e-03 0.682000 9.11e-02
Fructose metabolism 7 1.81e-03 0.681000 3.71e-02
Formation of the ureteric bud 5 1.09e-02 -0.658000 1.07e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.30e-03 0.656000 2.93e-02
LTC4-CYSLTR mediated IL4 production 5 1.23e-02 0.647000 1.16e-01
Fructose catabolism 5 1.75e-02 0.614000 1.46e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.83e-03 -0.602000 7.62e-02
MECP2 regulates transcription of neuronal ligands 5 2.00e-02 0.601000 1.56e-01
Defects in biotin (Btn) metabolism 8 4.16e-03 0.585000 6.31e-02
Alternative complement activation 5 2.38e-02 0.584000 1.71e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 9.75e-03 0.564000 9.97e-02
Phenylalanine metabolism 5 3.07e-02 0.558000 1.98e-01
MET activates RAP1 and RAC1 10 2.50e-03 -0.552000 4.59e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 2.65e-03 -0.549000 4.78e-02
MET activates PI3K/AKT signaling 5 3.62e-02 -0.541000 2.16e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.33e-02 0.540000 1.21e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.57e-02 -0.526000 1.79e-01
Reversible hydration of carbon dioxide 8 1.00e-02 -0.526000 1.01e-01
Propionyl-CoA catabolism 5 4.44e-02 0.519000 2.42e-01
Synthesis of PG 8 1.16e-02 0.515000 1.11e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 4.65e-02 0.514000 2.50e-01
Sulfide oxidation to sulfate 5 4.66e-02 0.514000 2.50e-01
Defective binding of VWF variant to GPIb:IX:V 7 1.90e-02 -0.512000 1.54e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.90e-02 -0.512000 1.54e-01
PTK6 Regulates Cell Cycle 6 3.44e-02 0.499000 2.10e-01
Activation of NOXA and translocation to mitochondria 5 5.67e-02 0.492000 2.74e-01
Molybdenum cofactor biosynthesis 6 3.85e-02 0.488000 2.25e-01
IFNG signaling activates MAPKs 8 1.74e-02 -0.486000 1.46e-01
Carnitine shuttle 12 3.65e-03 0.485000 5.98e-02
Unwinding of DNA 12 3.73e-03 0.483000 6.00e-02
Type I hemidesmosome assembly 8 1.85e-02 0.481000 1.52e-01
Signal attenuation 9 1.25e-02 -0.481000 1.17e-01
Creation of C4 and C2 activators 71 2.71e-12 0.480000 2.62e-09
Initial triggering of complement 79 2.97e-13 0.475000 5.73e-10
Translocation of ZAP-70 to Immunological synapse 24 6.15e-05 0.472000 4.75e-03
Classical antibody-mediated complement activation 69 1.45e-11 0.470000 9.36e-09
Estrogen-stimulated signaling through PRKCZ 6 4.67e-02 -0.469000 2.50e-01
POLB-Dependent Long Patch Base Excision Repair 8 2.37e-02 0.462000 1.71e-01
Diseases of Base Excision Repair 5 7.49e-02 0.460000 3.21e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 3.52e-02 -0.460000 2.13e-01
Biotin transport and metabolism 11 8.42e-03 0.459000 9.20e-02
Formation of the active cofactor, UDP-glucuronate 5 7.78e-02 -0.455000 3.27e-01
Modulation by Mtb of host immune system 7 3.75e-02 -0.454000 2.21e-01
Erythrocytes take up carbon dioxide and release oxygen 11 9.29e-03 -0.453000 9.71e-02
O2/CO2 exchange in erythrocytes 11 9.29e-03 -0.453000 9.71e-02
Phosphorylation of Emi1 6 5.47e-02 0.453000 2.67e-01
Organic anion transporters 7 3.88e-02 0.451000 2.25e-01
Scavenging of heme from plasma 70 9.70e-11 0.447000 4.68e-08
Synthesis of PI 5 8.65e-02 0.443000 3.41e-01
ATF6 (ATF6-alpha) activates chaperones 12 8.07e-03 -0.442000 8.96e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 8.75e-02 0.441000 3.44e-01
Aflatoxin activation and detoxification 14 4.26e-03 0.441000 6.33e-02
Cellular hexose transport 14 4.42e-03 0.439000 6.49e-02
Eicosanoids 6 6.34e-02 -0.438000 2.96e-01
Regulation of IFNG signaling 14 4.72e-03 -0.436000 6.71e-02
Acetylcholine regulates insulin secretion 9 2.38e-02 0.435000 1.71e-01
HDR through MMEJ (alt-NHEJ) 12 9.18e-03 0.434000 9.70e-02
Glycogen synthesis 11 1.28e-02 -0.433000 1.19e-01
Neurotoxicity of clostridium toxins 9 2.50e-02 0.431000 1.78e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 6.88e-02 0.429000 3.09e-01
Digestion 5 9.69e-02 -0.429000 3.67e-01
Signaling by MST1 5 9.75e-02 0.428000 3.69e-01
Platelet Adhesion to exposed collagen 16 3.08e-03 -0.427000 5.35e-02
Protein repair 6 7.06e-02 -0.426000 3.15e-01
Phenylalanine and tyrosine metabolism 9 2.78e-02 0.423000 1.86e-01
Biosynthesis of Lipoxins (LX) 6 7.62e-02 -0.418000 3.23e-01
Glucuronidation 9 3.23e-02 -0.412000 2.02e-01
Regulation of CDH11 mRNA translation by microRNAs 8 4.42e-02 0.411000 2.42e-01
Regulation of NPAS4 mRNA translation 8 4.42e-02 0.411000 2.42e-01
RHOT1 GTPase cycle 5 1.13e-01 -0.409000 3.91e-01
Regulation of PTEN localization 9 3.35e-02 -0.409000 2.07e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 4.86e-03 -0.407000 6.71e-02
Leading Strand Synthesis 14 8.80e-03 0.404000 9.44e-02
Polymerase switching 14 8.80e-03 0.404000 9.44e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.18e-02 -0.403000 1.12e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 8.85e-02 0.402000 3.45e-01
Processive synthesis on the lagging strand 15 7.22e-03 0.401000 8.44e-02
DNA strand elongation 32 9.48e-05 0.399000 5.74e-03
Coenzyme A biosynthesis 7 6.78e-02 0.399000 3.08e-01
Removal of the Flap Intermediate 14 9.94e-03 0.398000 1.01e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.97e-02 -0.396000 2.28e-01
CD22 mediated BCR regulation 58 2.00e-07 0.395000 4.43e-05
Attachment of GPI anchor to uPAR 7 7.30e-02 0.391000 3.18e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.91e-02 0.391000 1.54e-01
Negative feedback regulation of MAPK pathway 6 9.82e-02 -0.390000 3.70e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.95e-02 -0.390000 1.54e-01
Transport of connexons to the plasma membrane 12 1.95e-02 -0.390000 1.54e-01
Activation of the phototransduction cascade 8 5.65e-02 -0.389000 2.74e-01
SARS-CoV-2 modulates autophagy 11 2.55e-02 0.389000 1.79e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 7.48e-02 0.389000 3.21e-01
LGI-ADAM interactions 9 4.45e-02 0.387000 2.42e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.86e-03 -0.383000 6.16e-02
Sperm Motility And Taxes 6 1.05e-01 0.382000 3.81e-01
Phosphorylation of CD3 and TCR zeta chains 27 6.38e-04 0.380000 1.99e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 1.43e-01 -0.378000 4.34e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 1.09e-01 -0.378000 3.83e-01
Glycosphingolipid transport 7 8.43e-02 0.377000 3.38e-01
PD-1 signaling 28 6.02e-04 0.375000 1.97e-02
Mitochondrial RNA degradation 25 1.22e-03 -0.374000 2.87e-02
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 1.02e-02 -0.371000 1.02e-01
FCGR activation 76 2.27e-08 0.371000 7.30e-06
Hedgehog ligand biogenesis 47 1.11e-05 -0.370000 1.13e-03
Olfactory Signaling Pathway 61 5.73e-07 -0.370000 9.23e-05
Expression and translocation of olfactory receptors 56 1.81e-06 -0.369000 2.20e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 2.67e-04 0.367000 1.17e-02
Regulation of NPAS4 gene expression 11 3.54e-02 0.366000 2.13e-01
NFE2L2 regulates pentose phosphate pathway genes 8 7.44e-02 -0.364000 3.21e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.89e-03 -0.364000 6.16e-02
Synthesis of PIPs at the Golgi membrane 16 1.26e-02 0.360000 1.18e-01
Synthesis of PC 23 2.88e-03 -0.359000 5.15e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 6.30e-02 -0.358000 2.95e-01
GABA synthesis, release, reuptake and degradation 12 3.19e-02 0.358000 2.01e-01
Defects of platelet adhesion to exposed collagen 8 8.00e-02 -0.357000 3.30e-01
NR1H2 and NR1H3-mediated signaling 39 1.18e-04 0.356000 6.32e-03
Estrogen biosynthesis 5 1.68e-01 -0.356000 4.71e-01
Role of phospholipids in phagocytosis 88 8.09e-09 0.356000 3.13e-06
ROBO receptors bind AKAP5 7 1.03e-01 0.355000 3.79e-01
Spry regulation of FGF signaling 16 1.38e-02 -0.355000 1.25e-01
Uptake of dietary cobalamins into enterocytes 6 1.32e-01 0.355000 4.24e-01
CHL1 interactions 8 8.23e-02 -0.355000 3.33e-01
Lipophagy 7 1.04e-01 -0.355000 3.80e-01
Nucleotide biosynthesis 12 3.40e-02 0.353000 2.09e-01
Hh mutants are degraded by ERAD 42 8.17e-05 -0.351000 5.64e-03
Hh mutants abrogate ligand secretion 43 7.18e-05 -0.350000 5.14e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 9.04e-05 -0.349000 5.74e-03
Lagging Strand Synthesis 20 7.17e-03 0.347000 8.44e-02
Phosphate bond hydrolysis by NTPDase proteins 5 1.79e-01 0.347000 4.82e-01
PINK1-PRKN Mediated Mitophagy 31 8.81e-04 -0.345000 2.39e-02
Acetylcholine Neurotransmitter Release Cycle 11 4.82e-02 0.344000 2.54e-01
Post-transcriptional silencing by small RNAs 7 1.18e-01 0.341000 3.98e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 1.20e-01 0.339000 4.04e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 5.19e-02 0.338000 2.58e-01
Nectin/Necl trans heterodimerization 5 1.91e-01 0.338000 5.03e-01
RHOBTB1 GTPase cycle 23 5.07e-03 -0.338000 6.85e-02
Tandem pore domain potassium channels 5 1.91e-01 0.337000 5.03e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 4.09e-04 -0.336000 1.53e-02
Role of LAT2/NTAL/LAB on calcium mobilization 77 3.51e-07 0.336000 6.17e-05
Myoclonic epilepsy of Lafora 8 1.01e-01 -0.335000 3.73e-01
Degradation of GLI1 by the proteasome 46 9.51e-05 -0.333000 5.74e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 2.00e-04 -0.332000 9.89e-03
Scavenging by Class A Receptors 14 3.19e-02 -0.331000 2.01e-01
Synthesis of PIPs at the ER membrane 5 2.02e-01 0.329000 5.13e-01
G1/S-Specific Transcription 29 2.17e-03 0.329000 4.15e-02
Sodium/Proton exchangers 7 1.32e-01 0.329000 4.24e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.05e-02 0.328000 2.30e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 4.58e-03 0.328000 6.55e-02
MET receptor recycling 9 8.90e-02 -0.327000 3.45e-01
Toxicity of botulinum toxin type D (botD) 5 2.07e-01 0.326000 5.19e-01
Toxicity of botulinum toxin type F (botF) 5 2.07e-01 0.326000 5.19e-01
Acyl chain remodelling of PI 10 7.51e-02 -0.325000 3.21e-01
Maturation of hRSV A proteins 13 4.31e-02 -0.324000 2.39e-01
Disorders of Developmental Biology 12 5.21e-02 0.324000 2.58e-01
Disorders of Nervous System Development 12 5.21e-02 0.324000 2.58e-01
Loss of function of MECP2 in Rett syndrome 12 5.21e-02 0.324000 2.58e-01
Pervasive developmental disorders 12 5.21e-02 0.324000 2.58e-01
Activation of NF-kappaB in B cells 54 4.03e-05 -0.323000 3.54e-03
Resolution of Abasic Sites (AP sites) 38 5.95e-04 0.322000 1.97e-02
Complement cascade 100 2.74e-08 0.321000 7.58e-06
Insulin receptor recycling 24 6.44e-03 -0.321000 7.87e-02
Vif-mediated degradation of APOBEC3G 41 4.03e-04 -0.319000 1.53e-02
Axonal growth inhibition (RHOA activation) 7 1.44e-01 -0.319000 4.34e-01
p75NTR regulates axonogenesis 7 1.44e-01 -0.319000 4.34e-01
Degradation of GLI2 by the proteasome 45 2.22e-04 -0.318000 1.04e-02
Negative regulation of FGFR3 signaling 21 1.16e-02 -0.318000 1.11e-01
Regulation of Apoptosis 40 5.00e-04 -0.318000 1.74e-02
NFE2L2 regulating ER-stress associated genes 5 2.21e-01 -0.316000 5.36e-01
Interleukin-18 signaling 6 1.81e-01 -0.316000 4.85e-01
Eicosanoid ligand-binding receptors 13 4.92e-02 0.315000 2.55e-01
NPAS4 regulates expression of target genes 16 2.95e-02 -0.314000 1.93e-01
Defective pyroptosis 27 4.78e-03 0.314000 6.71e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.23e-02 0.313000 2.38e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.28e-02 0.313000 2.39e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 2.26e-01 -0.312000 5.38e-01
Josephin domain DUBs 10 8.74e-02 -0.312000 3.44e-01
PCNA-Dependent Long Patch Base Excision Repair 21 1.34e-02 0.312000 1.21e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 2.27e-01 -0.312000 5.38e-01
GLI3 is processed to GLI3R by the proteasome 46 2.55e-04 -0.312000 1.15e-02
Infection with Mycobacterium tuberculosis 26 5.97e-03 -0.312000 7.68e-02
SOS-mediated signalling 7 1.54e-01 -0.311000 4.53e-01
RHO GTPases activate IQGAPs 25 7.14e-03 -0.311000 8.44e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 1.88e-01 0.310000 5.02e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 3.19e-02 0.310000 2.01e-01
Glycerophospholipid catabolism 6 1.90e-01 0.309000 5.03e-01
Aggrephagy 34 1.84e-03 -0.309000 3.73e-02
Gluconeogenesis 19 1.99e-02 0.309000 1.56e-01
Crosslinking of collagen fibrils 15 3.85e-02 -0.309000 2.25e-01
Chemokine receptors bind chemokines 39 9.02e-04 -0.307000 2.39e-02
Regulation of Complement cascade 96 2.06e-07 0.307000 4.43e-05
Folding of actin by CCT/TriC 10 9.32e-02 -0.307000 3.58e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 2.37e-01 -0.305000 5.49e-01
RHO GTPases Activate ROCKs 18 2.51e-02 -0.305000 1.78e-01
Suppression of phagosomal maturation 12 6.75e-02 -0.305000 3.08e-01
Binding and Uptake of Ligands by Scavenger Receptors 94 3.48e-07 0.304000 6.17e-05
ARMS-mediated activation 6 1.97e-01 -0.304000 5.13e-01
Defective CFTR causes cystic fibrosis 47 3.12e-04 -0.304000 1.30e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 1.65e-01 0.303000 4.67e-01
Post-chaperonin tubulin folding pathway 18 2.62e-02 -0.303000 1.81e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 2.42e-01 0.302000 5.57e-01
DNA replication initiation 8 1.40e-01 0.301000 4.32e-01
Passive transport by Aquaporins 6 2.02e-01 -0.301000 5.13e-01
STAT5 activation downstream of FLT3 ITD mutants 9 1.18e-01 -0.301000 3.98e-01
CS/DS degradation 9 1.18e-01 0.301000 3.98e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.33e-02 -0.301000 1.71e-01
Sema4D induced cell migration and growth-cone collapse 19 2.33e-02 -0.301000 1.71e-01
Relaxin receptors 5 2.46e-01 -0.299000 5.61e-01
Regulated proteolysis of p75NTR 11 8.63e-02 -0.299000 3.41e-01
RHOBTB GTPase Cycle 35 2.28e-03 -0.298000 4.31e-02
PI-3K cascade:FGFR3 10 1.03e-01 -0.298000 3.78e-01
Hyaluronan uptake and degradation 12 7.44e-02 0.297000 3.21e-01
Hyaluronan metabolism 16 3.97e-02 0.297000 2.28e-01
RHOBTB2 GTPase cycle 23 1.39e-02 -0.296000 1.25e-01
Cytosolic iron-sulfur cluster assembly 13 6.47e-02 0.296000 2.99e-01
TGFBR3 expression 20 2.25e-02 0.295000 1.68e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 2.56e-03 -0.295000 4.67e-02
Phosphate bond hydrolysis by NUDT proteins 7 1.78e-01 -0.294000 4.82e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.40e-04 -0.293000 1.57e-02
Activation of AMPK downstream of NMDARs 20 2.33e-02 -0.293000 1.71e-01
Role of second messengers in netrin-1 signaling 6 2.15e-01 0.293000 5.29e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.09e-01 -0.292000 3.84e-01
Physiological factors 9 1.29e-01 -0.292000 4.21e-01
Response of Mtb to phagocytosis 22 1.86e-02 -0.290000 1.52e-01
Downstream signaling events of B Cell Receptor (BCR) 68 3.58e-05 -0.290000 3.29e-03
Polymerase switching on the C-strand of the telomere 26 1.08e-02 0.289000 1.07e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.39e-03 -0.288000 3.09e-02
FCGR3A-mediated IL10 synthesis 99 7.28e-07 0.288000 1.08e-04
Activation of the pre-replicative complex 32 4.84e-03 0.288000 6.71e-02
Acetylcholine binding and downstream events 5 2.66e-01 0.287000 5.86e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.66e-01 0.287000 5.86e-01
Response to metal ions 6 2.23e-01 -0.287000 5.38e-01
RUNX1 regulates expression of components of tight junctions 5 2.67e-01 -0.286000 5.86e-01
COPI-independent Golgi-to-ER retrograde traffic 45 8.91e-04 -0.286000 2.39e-02
FCERI mediated MAPK activation 93 1.83e-06 0.286000 2.20e-04
Degradation of DVL 43 1.17e-03 -0.286000 2.79e-02
GPVI-mediated activation cascade 33 4.47e-03 -0.286000 6.49e-02
Activation of PUMA and translocation to mitochondria 9 1.38e-01 0.286000 4.29e-01
Vpu mediated degradation of CD4 39 2.04e-03 -0.285000 3.98e-02
ABC transporter disorders 60 1.38e-04 -0.284000 7.03e-03
HDL remodeling 6 2.28e-01 0.284000 5.38e-01
Ubiquitin-dependent degradation of Cyclin D 39 2.17e-03 -0.284000 4.15e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 4.13e-04 -0.283000 1.53e-02
Signaling by activated point mutants of FGFR1 5 2.73e-01 -0.283000 5.96e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.61e-03 -0.283000 9.90e-02
Prolonged ERK activation events 13 7.81e-02 -0.282000 3.28e-01
tRNA processing in the mitochondrion 24 1.69e-02 -0.282000 1.44e-01
TNFR1-mediated ceramide production 6 2.32e-01 0.282000 5.42e-01
Ketone body metabolism 8 1.68e-01 0.281000 4.71e-01
Regulation of RAS by GAPs 55 3.15e-04 -0.281000 1.30e-02
Negative regulation of NOTCH4 signaling 44 1.30e-03 -0.280000 2.93e-02
Degradation of AXIN 42 1.71e-03 -0.280000 3.58e-02
FCERI mediated Ca+2 mobilization 92 3.65e-06 0.279000 3.91e-04
Mitochondrial Uncoupling 6 2.38e-01 0.278000 5.50e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 2.82e-01 -0.278000 6.03e-01
Maple Syrup Urine Disease 5 2.82e-01 -0.278000 6.03e-01
Regulation of ornithine decarboxylase (ODC) 38 3.09e-03 -0.277000 5.35e-02
Generation of second messenger molecules 38 3.10e-03 0.277000 5.35e-02
Defective GALNT3 causes HFTC 9 1.50e-01 0.277000 4.46e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 2.84e-01 -0.277000 6.04e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 2.06e-01 0.276000 5.19e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.44e-02 -0.275000 3.21e-01
RSK activation 7 2.07e-01 -0.275000 5.19e-01
Malate-aspartate shuttle 8 1.78e-01 0.275000 4.82e-01
Synthesis of Ketone Bodies 6 2.43e-01 0.275000 5.58e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 3.33e-03 -0.275000 5.56e-02
Platelet Aggregation (Plug Formation) 30 9.10e-03 -0.275000 9.66e-02
Regulation of FZD by ubiquitination 16 5.73e-02 -0.275000 2.76e-01
Regulation of PTEN stability and activity 55 4.31e-04 -0.274000 1.57e-02
RUNX3 regulates p14-ARF 10 1.33e-01 -0.274000 4.24e-01
Regulation of RUNX3 expression and activity 45 1.48e-03 -0.274000 3.26e-02
Defects in vitamin and cofactor metabolism 21 3.01e-02 0.273000 1.96e-01
Frs2-mediated activation 11 1.17e-01 -0.273000 3.98e-01
Sema4D in semaphorin signaling 22 2.74e-02 -0.272000 1.84e-01
Glycogen metabolism 21 3.21e-02 -0.270000 2.01e-01
RHO GTPases activate KTN1 11 1.21e-01 -0.270000 4.07e-01
Netrin mediated repulsion signals 5 2.98e-01 0.269000 6.18e-01
Transcription of E2F targets under negative control by DREAM complex 19 4.28e-02 0.268000 2.39e-01
Asymmetric localization of PCP proteins 49 1.16e-03 -0.268000 2.79e-02
Synthesis of PE 12 1.08e-01 -0.268000 3.83e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 4.02e-04 -0.266000 1.53e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 6.56e-02 -0.266000 3.02e-01
Negative regulation of FGFR4 signaling 22 3.10e-02 -0.266000 1.98e-01
Chaperone Mediated Autophagy 20 3.98e-02 -0.265000 2.28e-01
TNFs bind their physiological receptors 25 2.18e-02 0.265000 1.65e-01
Maturation of nucleoprotein 9694631 15 7.56e-02 -0.265000 3.22e-01
Aryl hydrocarbon receptor signalling 6 2.61e-01 -0.265000 5.80e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 9.63e-03 -0.264000 9.90e-02
Arachidonate production from DAG 5 3.06e-01 0.264000 6.23e-01
SCF-beta-TrCP mediated degradation of Emi1 42 3.15e-03 -0.263000 5.39e-02
Degradation of cysteine and homocysteine 13 1.00e-01 0.263000 3.73e-01
TGFBR3 regulates TGF-beta signaling 8 1.98e-01 0.263000 5.13e-01
CDC6 association with the ORC:origin complex 8 1.98e-01 0.263000 5.13e-01
Signaling by FLT3 ITD and TKD mutants 15 7.84e-02 -0.262000 3.28e-01
Zinc influx into cells by the SLC39 gene family 9 1.74e-01 -0.262000 4.74e-01
ADP signalling through P2Y purinoceptor 12 18 5.45e-02 -0.262000 2.67e-01
Maturation of nucleoprotein 9683610 11 1.34e-01 -0.261000 4.24e-01
Beta-catenin phosphorylation cascade 17 6.34e-02 -0.260000 2.96e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 8.25e-02 0.259000 3.33e-01
Rap1 signalling 14 9.38e-02 -0.259000 3.60e-01
Negative regulation of MET activity 18 5.79e-02 -0.258000 2.78e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 2.54e-02 -0.258000 1.79e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 1.08e-01 0.257000 3.83e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 2.75e-01 -0.257000 5.97e-01
ER-Phagosome pathway 75 1.17e-04 -0.257000 6.32e-03
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 1.24e-01 -0.257000 4.12e-01
Negative regulation of FGFR1 signaling 25 2.63e-02 -0.257000 1.81e-01
AKT phosphorylates targets in the nucleus 9 1.83e-01 0.256000 4.90e-01
Sodium-coupled phosphate cotransporters 5 3.21e-01 0.256000 6.36e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.41e-01 -0.256000 4.33e-01
Mitophagy 38 6.31e-03 -0.256000 7.76e-02
Base Excision Repair 57 8.28e-04 0.256000 2.32e-02
Gap junction assembly 17 6.81e-02 -0.256000 3.08e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.26e-01 -0.255000 4.16e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 3.15e-02 -0.254000 2.01e-01
Anchoring fibril formation 10 1.66e-01 -0.253000 4.67e-01
Formation of axial mesoderm 6 2.83e-01 -0.253000 6.04e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.28e-01 -0.252000 6.42e-01
Stabilization of p53 43 4.21e-03 -0.252000 6.31e-02
Regulation of MITF-M-dependent genes involved in apoptosis 16 8.10e-02 0.252000 3.32e-01
Molecules associated with elastic fibres 26 2.65e-02 0.251000 1.82e-01
Metabolic disorders of biological oxidation enzymes 26 2.71e-02 -0.250000 1.83e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.35e-01 -0.249000 4.26e-01
Regulation of FOXO transcriptional activity by acetylation 10 1.72e-01 -0.249000 4.73e-01
Degradation of beta-catenin by the destruction complex 72 2.56e-04 -0.249000 1.15e-02
Activated NTRK3 signals through RAS 7 2.55e-01 -0.248000 5.73e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.74e-01 -0.248000 4.75e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 7.34e-03 -0.248000 8.44e-02
p53-Independent DNA Damage Response 39 7.34e-03 -0.248000 8.44e-02
p53-Independent G1/S DNA damage checkpoint 39 7.34e-03 -0.248000 8.44e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 2.56e-01 -0.248000 5.73e-01
Activation of C3 and C5 7 2.58e-01 0.247000 5.77e-01
EPHA-mediated growth cone collapse 21 5.03e-02 -0.247000 2.57e-01
Glutathione synthesis and recycling 10 1.77e-01 0.247000 4.82e-01
Mismatch Repair 15 9.82e-02 0.247000 3.70e-01
Regulation of MECP2 expression and activity 29 2.16e-02 0.246000 1.65e-01
Diseases of hemostasis 15 9.91e-02 -0.246000 3.71e-01
Signaling by RNF43 mutants 7 2.61e-01 -0.245000 5.80e-01
PI-3K cascade:FGFR1 13 1.26e-01 -0.245000 4.15e-01
Phase 2 - plateau phase 11 1.59e-01 0.245000 4.61e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 3.48e-02 -0.244000 2.11e-01
Removal of the Flap Intermediate from the C-strand 17 8.20e-02 0.244000 3.33e-01
RAS processing 23 4.37e-02 -0.243000 2.41e-01
Proteasome assembly 50 2.97e-03 -0.243000 5.26e-02
NIK–>noncanonical NF-kB signaling 46 4.46e-03 -0.242000 6.49e-02
Activation of the AP-1 family of transcription factors 10 1.87e-01 -0.241000 5.00e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 9.57e-02 -0.241000 3.64e-01
Activation of BAD and translocation to mitochondria 15 1.07e-01 -0.240000 3.83e-01
Alpha-protein kinase 1 signaling pathway 11 1.68e-01 -0.240000 4.71e-01
G beta:gamma signalling through BTK 15 1.08e-01 -0.240000 3.83e-01
Prevention of phagosomal-lysosomal fusion 9 2.13e-01 -0.240000 5.29e-01
G alpha (z) signalling events 36 1.30e-02 -0.239000 1.19e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.09e-01 -0.239000 3.83e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 1.09e-01 -0.239000 3.83e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 1.09e-01 -0.239000 3.83e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 1.09e-01 -0.239000 3.83e-01
Signaling by CTNNB1 phospho-site mutants 15 1.09e-01 -0.239000 3.83e-01
Signaling by GSK3beta mutants 15 1.09e-01 -0.239000 3.83e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 4.19e-03 -0.239000 6.31e-02
DNA methylation 18 7.95e-02 0.239000 3.30e-01
DAP12 signaling 28 2.88e-02 -0.239000 1.91e-01
RHO GTPases Activate WASPs and WAVEs 35 1.48e-02 -0.238000 1.30e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.38e-01 -0.238000 4.29e-01
Cellular response to hypoxia 59 1.60e-03 -0.238000 3.46e-02
SUMOylation of DNA replication proteins 46 5.40e-03 0.237000 7.15e-02
Telomere C-strand (Lagging Strand) Synthesis 34 1.68e-02 0.237000 1.44e-01
G0 and Early G1 27 3.33e-02 0.237000 2.07e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 1.96e-01 0.236000 5.10e-01
Regulation of CDH11 gene transcription 5 3.61e-01 0.236000 6.56e-01
Killing mechanisms 9 2.21e-01 0.236000 5.36e-01
WNT5:FZD7-mediated leishmania damping 9 2.21e-01 0.236000 5.36e-01
Miro GTPase Cycle 8 2.49e-01 -0.235000 5.65e-01
PRC2 methylates histones and DNA 27 3.43e-02 0.235000 2.10e-01
Reelin signalling pathway 5 3.63e-01 -0.235000 6.57e-01
Metabolism of polyamines 46 5.97e-03 -0.234000 7.68e-02
Formation of apoptosome 11 1.79e-01 -0.234000 4.82e-01
Regulation of the apoptosome activity 11 1.79e-01 -0.234000 4.82e-01
SUMOylation of DNA methylation proteins 16 1.07e-01 0.233000 3.83e-01
IRAK1 recruits IKK complex 14 1.32e-01 -0.233000 4.24e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 1.32e-01 -0.233000 4.24e-01
EGFR downregulation 27 3.69e-02 -0.232000 2.19e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 1.64e-01 -0.232000 4.65e-01
Signaling by NOTCH4 70 7.91e-04 -0.232000 2.28e-02
Purine ribonucleoside monophosphate biosynthesis 9 2.28e-01 0.232000 5.38e-01
rRNA modification in the mitochondrion 8 2.56e-01 0.232000 5.73e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 8.87e-02 0.232000 3.45e-01
Signaling by FGFR3 32 2.33e-02 -0.232000 1.71e-01
Resolution of D-Loop Structures 35 1.78e-02 0.232000 1.48e-01
GP1b-IX-V activation signalling 12 1.65e-01 -0.231000 4.67e-01
Incretin synthesis, secretion, and inactivation 14 1.34e-01 -0.231000 4.24e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.34e-01 -0.231000 4.24e-01
FGFR2b ligand binding and activation 6 3.27e-01 0.231000 6.40e-01
Other interleukin signaling 19 8.16e-02 0.231000 3.32e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.99e-02 0.231000 1.56e-01
Polo-like kinase mediated events 16 1.10e-01 0.231000 3.85e-01
DAP12 interactions 39 1.27e-02 -0.231000 1.18e-01
RUNX3 regulates CDKN1A transcription 7 2.92e-01 0.230000 6.15e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.73e-02 -0.229000 1.46e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 3.75e-01 0.229000 6.72e-01
Prostanoid ligand receptors 8 2.63e-01 0.229000 5.82e-01
Fertilization 12 1.70e-01 0.229000 4.72e-01
Signaling by FGFR3 in disease 14 1.39e-01 -0.228000 4.30e-01
Diseases associated with surfactant metabolism 6 3.34e-01 -0.228000 6.42e-01
Vpr-mediated nuclear import of PICs 34 2.15e-02 0.228000 1.65e-01
Nuclear events mediated by NFE2L2 82 3.79e-04 -0.227000 1.52e-02
Autodegradation of Cdh1 by Cdh1:APC/C 54 3.98e-03 -0.226000 6.26e-02
Interferon alpha/beta signaling 64 1.72e-03 -0.226000 3.58e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.58e-01 -0.226000 4.60e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 1.18e-01 -0.226000 3.98e-01
Serotonin Neurotransmitter Release Cycle 15 1.31e-01 0.225000 4.24e-01
Selective autophagy 77 6.40e-04 -0.225000 1.99e-02
Interleukin-35 Signalling 12 1.77e-01 -0.225000 4.82e-01
Signaling by FGFR4 32 2.80e-02 -0.224000 1.86e-01
Regulation of TLR by endogenous ligand 15 1.32e-01 0.224000 4.24e-01
Signaling by WNT in cancer 30 3.35e-02 -0.224000 2.07e-01
The phototransduction cascade 26 4.81e-02 -0.224000 2.54e-01
NFE2L2 regulating tumorigenic genes 11 1.99e-01 -0.224000 5.13e-01
VEGF binds to VEGFR leading to receptor dimerization 5 3.88e-01 0.223000 6.78e-01
VEGF ligand-receptor interactions 5 3.88e-01 0.223000 6.78e-01
Activation of RAC1 downstream of NMDARs 7 3.07e-01 -0.223000 6.23e-01
PCP/CE pathway 75 8.41e-04 -0.223000 2.32e-02
Keratinization 37 1.93e-02 -0.222000 1.54e-01
Platelet sensitization by LDL 16 1.24e-01 -0.222000 4.12e-01
Class I peroxisomal membrane protein import 20 8.58e-02 0.222000 3.40e-01
Pregnenolone biosynthesis 10 2.24e-01 0.222000 5.38e-01
G2 Phase 5 3.90e-01 -0.222000 6.79e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.53e-01 0.221000 4.50e-01
SHC-mediated cascade:FGFR3 10 2.27e-01 -0.221000 5.38e-01
Interleukin-12 signaling 44 1.13e-02 -0.221000 1.09e-01
Interactions of Vpr with host cellular proteins 37 2.03e-02 0.220000 1.58e-01
DARPP-32 events 22 7.38e-02 -0.220000 3.21e-01
Regulation of RUNX2 expression and activity 54 5.15e-03 -0.220000 6.89e-02
Transferrin endocytosis and recycling 26 5.24e-02 -0.220000 2.58e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.73e-02 -0.220000 2.21e-01
Intrinsic Pathway of Fibrin Clot Formation 15 1.42e-01 -0.219000 4.33e-01
Growth hormone receptor signaling 21 8.25e-02 -0.219000 3.33e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 7.58e-02 0.219000 3.22e-01
Formation of Fibrin Clot (Clotting Cascade) 26 5.36e-02 -0.219000 2.64e-01
VLDLR internalisation and degradation 16 1.31e-01 -0.218000 4.24e-01
Activation of ATR in response to replication stress 37 2.19e-02 0.218000 1.65e-01
MET promotes cell motility 33 3.05e-02 -0.218000 1.98e-01
Histidine catabolism 7 3.19e-01 0.217000 6.35e-01
Regulation of localization of FOXO transcription factors 11 2.12e-01 -0.217000 5.27e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 3.34e-03 0.217000 5.56e-02
Cardiogenesis 16 1.33e-01 0.217000 4.24e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.02e-02 0.216000 2.29e-01
CDH11 homotypic and heterotypic interactions 6 3.59e-01 0.216000 6.56e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 3.22e-01 0.216000 6.36e-01
ABC-family proteins mediated transport 81 7.71e-04 -0.216000 2.27e-02
Sphingolipid de novo biosynthesis 34 2.94e-02 -0.216000 1.93e-01
Na+/Cl- dependent neurotransmitter transporters 8 2.91e-01 -0.216000 6.14e-01
Inactivation of CDC42 and RAC1 7 3.23e-01 -0.216000 6.37e-01
Formation of the cornified envelope 36 2.52e-02 -0.216000 1.78e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 3.24e-01 -0.215000 6.37e-01
Somitogenesis 41 1.72e-02 -0.215000 1.46e-01
p130Cas linkage to MAPK signaling for integrins 11 2.18e-01 -0.215000 5.34e-01
Scavenging by Class F Receptors 5 4.07e-01 -0.214000 6.91e-01
PKMTs methylate histone lysines 44 1.41e-02 0.214000 1.26e-01
NFE2L2 regulating MDR associated enzymes 8 2.95e-01 -0.214000 6.17e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.66e-02 0.214000 1.82e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 3.65e-03 -0.213000 5.98e-02
APC/C:Cdc20 mediated degradation of Securin 55 6.21e-03 -0.213000 7.69e-02
Peptide ligand-binding receptors 101 2.13e-04 -0.213000 1.03e-02
SUMOylation of transcription factors 16 1.41e-01 0.213000 4.33e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.30e-01 0.212000 4.22e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.30e-01 0.212000 4.22e-01
RUNX3 regulates NOTCH signaling 14 1.69e-01 -0.212000 4.72e-01
Induction of Cell-Cell Fusion 8 2.99e-01 0.212000 6.18e-01
Purine catabolism 16 1.43e-01 -0.211000 4.34e-01
Signalling to ERKs 32 3.86e-02 -0.211000 2.25e-01
Budding and maturation of HIV virion 26 6.26e-02 -0.211000 2.95e-01
Antigen processing-Cross presentation 89 5.82e-04 -0.211000 1.97e-02
APC truncation mutants have impaired AXIN binding 14 1.73e-01 -0.210000 4.73e-01
AXIN missense mutants destabilize the destruction complex 14 1.73e-01 -0.210000 4.73e-01
Signaling by AMER1 mutants 14 1.73e-01 -0.210000 4.73e-01
Signaling by APC mutants 14 1.73e-01 -0.210000 4.73e-01
Signaling by AXIN mutants 14 1.73e-01 -0.210000 4.73e-01
Truncations of AMER1 destabilize the destruction complex 14 1.73e-01 -0.210000 4.73e-01
Fatty acids 6 3.74e-01 -0.210000 6.71e-01
RHOH GTPase cycle 34 3.50e-02 -0.209000 2.12e-01
Methylation 13 1.96e-01 -0.207000 5.10e-01
Mitochondrial tRNA aminoacylation 21 1.01e-01 0.207000 3.73e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 1.11e-03 0.207000 2.72e-02
DNA Damage Reversal 8 3.11e-01 0.207000 6.27e-01
Suppression of apoptosis 7 3.44e-01 -0.206000 6.46e-01
Alpha-oxidation of phytanate 6 3.82e-01 0.206000 6.75e-01
Integrin signaling 22 9.49e-02 -0.206000 3.63e-01
Negative regulation of FGFR2 signaling 24 8.12e-02 -0.206000 3.32e-01
NRIF signals cell death from the nucleus 15 1.69e-01 -0.205000 4.71e-01
Sema4D mediated inhibition of cell attachment and migration 7 3.48e-01 -0.205000 6.48e-01
CYP2E1 reactions 6 3.85e-01 0.205000 6.78e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 5.22e-02 -0.205000 2.58e-01
Cytochrome c-mediated apoptotic response 13 2.02e-01 -0.204000 5.13e-01
Formation of paraxial mesoderm 52 1.08e-02 -0.204000 1.07e-01
RHO GTPases activate PAKs 20 1.14e-01 -0.204000 3.92e-01
Specification of primordial germ cells 6 3.91e-01 -0.202000 6.79e-01
CREB phosphorylation 7 3.54e-01 -0.202000 6.52e-01
KEAP1-NFE2L2 pathway 107 3.05e-04 -0.202000 1.30e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.50e-01 0.201000 4.47e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 8.14e-02 0.201000 3.32e-01
Interleukin-12 family signaling 53 1.15e-02 -0.201000 1.10e-01
Noncanonical activation of NOTCH3 8 3.26e-01 -0.201000 6.40e-01
Neurexins and neuroligins 40 2.85e-02 0.200000 1.89e-01
Displacement of DNA glycosylase by APEX1 9 2.99e-01 0.200000 6.18e-01
Long-term potentiation 18 1.42e-01 0.200000 4.33e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 7.24e-02 -0.200000 3.18e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 6.97e-03 -0.200000 8.32e-02
Pyrimidine catabolism 9 3.00e-01 -0.200000 6.18e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 7.51e-03 -0.200000 8.58e-02
Regulation of TP53 Activity through Association with Co-factors 13 2.15e-01 0.199000 5.29e-01
Transcriptional regulation by RUNX3 81 2.04e-03 -0.198000 3.98e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 4.00e-01 0.198000 6.85e-01
Proton-coupled monocarboxylate transport 6 4.03e-01 -0.197000 6.88e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 2.91e-02 -0.197000 1.92e-01
Signal amplification 28 7.14e-02 -0.197000 3.16e-01
Late endosomal microautophagy 30 6.29e-02 -0.196000 2.95e-01
RHOT2 GTPase cycle 7 3.70e-01 -0.196000 6.66e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.63e-01 0.195000 4.65e-01
Interleukin-1 processing 8 3.39e-01 0.195000 6.42e-01
IKK complex recruitment mediated by RIP1 23 1.05e-01 -0.195000 3.82e-01
PI-3K cascade:FGFR4 11 2.63e-01 -0.195000 5.82e-01
Cleavage of the damaged purine 22 1.14e-01 0.195000 3.92e-01
Depurination 22 1.14e-01 0.195000 3.92e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 1.14e-01 0.195000 3.92e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 1.53e-01 -0.194000 4.50e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 1.53e-01 -0.194000 4.50e-01
Hedgehog ‘on’ state 65 6.91e-03 -0.194000 8.31e-02
Calcitonin-like ligand receptors 5 4.53e-01 -0.194000 7.38e-01
Acyl chain remodelling of PS 14 2.10e-01 -0.194000 5.22e-01
Glutathione conjugation 28 7.67e-02 0.193000 3.24e-01
NrCAM interactions 6 4.13e-01 0.193000 6.95e-01
Methionine salvage pathway 6 4.13e-01 0.193000 6.95e-01
Telomere C-strand synthesis initiation 13 2.29e-01 0.193000 5.39e-01
Phase 3 - rapid repolarisation 6 4.15e-01 0.192000 6.99e-01
Processive synthesis on the C-strand of the telomere 19 1.48e-01 0.192000 4.42e-01
Inwardly rectifying K+ channels 24 1.04e-01 -0.191000 3.81e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 8.61e-03 -0.191000 9.34e-02
Regulation of CDH11 Expression and Function 23 1.12e-01 0.191000 3.91e-01
MAPK1 (ERK2) activation 9 3.21e-01 -0.191000 6.36e-01
NF-kB is activated and signals survival 12 2.52e-01 -0.191000 5.68e-01
Netrin-1 signaling 35 5.20e-02 -0.190000 2.58e-01
DNA Damage/Telomere Stress Induced Senescence 42 3.38e-02 0.189000 2.09e-01
TGFBR3 PTM regulation 10 3.01e-01 -0.189000 6.19e-01
Kidney development 17 1.78e-01 -0.189000 4.82e-01
Golgi Associated Vesicle Biogenesis 55 1.56e-02 -0.189000 1.36e-01
SCF(Skp2)-mediated degradation of p27/p21 50 2.12e-02 -0.188000 1.64e-01
Viral Messenger RNA Synthesis 44 3.08e-02 0.188000 1.98e-01
SUMOylation of SUMOylation proteins 35 5.41e-02 0.188000 2.65e-01
Signaling by RAF1 mutants 37 4.78e-02 -0.188000 2.53e-01
Interleukin-1 signaling 99 1.23e-03 -0.188000 2.87e-02
Termination of O-glycan biosynthesis 16 1.95e-01 0.187000 5.09e-01
SHC-related events triggered by IGF1R 8 3.60e-01 -0.187000 6.56e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 2.63e-01 -0.187000 5.82e-01
TRAF3-dependent IRF activation pathway 13 2.44e-01 0.187000 5.59e-01
HS-GAG degradation 19 1.60e-01 0.186000 4.61e-01
mRNA 3’-end processing 57 1.52e-02 -0.186000 1.33e-01
SHC-mediated cascade:FGFR1 13 2.46e-01 -0.186000 5.61e-01
CDK-mediated phosphorylation and removal of Cdc6 60 1.29e-02 -0.186000 1.19e-01
Norepinephrine Neurotransmitter Release Cycle 14 2.31e-01 0.185000 5.40e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 9.63e-02 0.185000 3.66e-01
G-protein activation 19 1.64e-01 -0.184000 4.65e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 3.13e-01 0.184000 6.29e-01
Activation of RAS in B cells 5 4.77e-01 -0.184000 7.60e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 7.24e-02 0.184000 3.18e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 7.24e-02 0.184000 3.18e-01
BBSome-mediated cargo-targeting to cilium 22 1.37e-01 0.183000 4.29e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 8.83e-02 -0.183000 3.45e-01
Homology Directed Repair 110 9.33e-04 0.183000 2.44e-02
Dermatan sulfate biosynthesis 6 4.40e-01 -0.182000 7.25e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.96e-01 -0.182000 6.18e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 3.19e-01 -0.182000 6.35e-01
Diseases of programmed cell death 58 1.66e-02 0.182000 1.43e-01
E2F-enabled inhibition of pre-replication complex formation 9 3.45e-01 0.182000 6.46e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 7.55e-02 0.182000 3.22e-01
Triglyceride biosynthesis 10 3.20e-01 -0.182000 6.36e-01
Regulation of Expression and Function of Type II Classical Cadherins 25 1.16e-01 0.181000 3.97e-01
Regulation of Homotypic Cell-Cell Adhesion 25 1.16e-01 0.181000 3.97e-01
Non-integrin membrane-ECM interactions 51 2.53e-02 -0.181000 1.78e-01
MAPK6/MAPK4 signaling 69 9.41e-03 -0.181000 9.78e-02
Nicotinamide salvaging 15 2.26e-01 -0.181000 5.38e-01
IkBA variant leads to EDA-ID 7 4.08e-01 -0.180000 6.92e-01
Signaling by EGFR 48 3.06e-02 -0.180000 1.98e-01
Downregulation of TGF-beta receptor signaling 26 1.11e-01 -0.180000 3.89e-01
Platelet activation, signaling and aggregation 223 3.52e-06 -0.180000 3.91e-04
GAB1 signalosome 15 2.28e-01 -0.180000 5.38e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 1.99e-01 0.180000 5.13e-01
Signaling by high-kinase activity BRAF mutants 33 7.43e-02 -0.180000 3.21e-01
CLEC7A (Dectin-1) signaling 86 4.03e-03 -0.179000 6.27e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 2.46e-01 -0.179000 5.61e-01
Metal ion SLC transporters 19 1.78e-01 -0.179000 4.82e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 8.05e-02 0.179000 3.31e-01
Regulation of PTEN gene transcription 59 1.78e-02 0.178000 1.48e-01
Signaling by NODAL 15 2.32e-01 -0.178000 5.42e-01
HDR through Homologous Recombination (HRR) 68 1.12e-02 0.178000 1.09e-01
HDACs deacetylate histones 45 3.90e-02 0.178000 2.26e-01
Transcriptional Regulation by E2F6 34 7.28e-02 0.178000 3.18e-01
MAP kinase activation 63 1.47e-02 -0.178000 1.30e-01
Adherens junctions interactions 41 4.91e-02 0.178000 2.55e-01
Syndecan interactions 26 1.18e-01 -0.177000 3.98e-01
p53-Dependent G1 DNA Damage Response 52 2.70e-02 -0.177000 1.83e-01
p53-Dependent G1/S DNA damage checkpoint 52 2.70e-02 -0.177000 1.83e-01
Recycling pathway of L1 40 5.24e-02 -0.177000 2.58e-01
Activated NTRK2 signals through RAS 6 4.53e-01 -0.177000 7.38e-01
Impaired BRCA2 binding to PALB2 24 1.34e-01 0.177000 4.24e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 5.06e-02 -0.176000 2.57e-01
Signaling by RAS mutants 41 5.06e-02 -0.176000 2.57e-01
Signaling by moderate kinase activity BRAF mutants 41 5.06e-02 -0.176000 2.57e-01
Signaling downstream of RAS mutants 41 5.06e-02 -0.176000 2.57e-01
Platelet degranulation 106 1.70e-03 -0.176000 3.58e-02
RAF activation 33 7.97e-02 -0.176000 3.30e-01
HDMs demethylate histones 22 1.52e-01 0.176000 4.50e-01
Downstream signaling of activated FGFR3 17 2.09e-01 -0.176000 5.21e-01
Nef and signal transduction 8 3.88e-01 -0.176000 6.78e-01
MAP2K and MAPK activation 36 6.74e-02 -0.176000 3.08e-01
Uptake and function of anthrax toxins 11 3.12e-01 -0.176000 6.28e-01
Regulation of signaling by CBL 22 1.55e-01 -0.175000 4.54e-01
FRS-mediated FGFR3 signaling 12 2.94e-01 -0.175000 6.15e-01
Endosomal/Vacuolar pathway 12 2.94e-01 -0.175000 6.15e-01
Translation of Structural Proteins 9694635 56 2.36e-02 -0.175000 1.71e-01
rRNA processing in the mitochondrion 24 1.38e-01 -0.175000 4.29e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.60e-02 -0.174000 1.39e-01
Interleukin-1 family signaling 127 7.00e-04 -0.174000 2.15e-02
Export of Viral Ribonucleoproteins from Nucleus 33 8.52e-02 0.173000 3.40e-01
Signaling by CSF3 (G-CSF) 29 1.08e-01 -0.173000 3.83e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.62e-01 -0.172000 4.64e-01
Defective GALNT12 causes CRCS1 9 3.72e-01 0.172000 6.68e-01
Laminin interactions 26 1.31e-01 -0.171000 4.24e-01
Signaling by LTK in cancer 7 4.34e-01 -0.171000 7.18e-01
Glycogen breakdown (glycogenolysis) 12 3.08e-01 -0.170000 6.24e-01
L1CAM interactions 100 3.32e-03 -0.170000 5.56e-02
Presynaptic depolarization and calcium channel opening 8 4.07e-01 0.169000 6.91e-01
Release of apoptotic factors from the mitochondria 6 4.73e-01 0.169000 7.59e-01
Defective factor IX causes hemophilia B 6 4.74e-01 -0.169000 7.59e-01
Phospholipase C-mediated cascade; FGFR3 5 5.14e-01 -0.169000 7.84e-01
Signaling by Hippo 18 2.16e-01 -0.169000 5.31e-01
Calnexin/calreticulin cycle 26 1.37e-01 -0.168000 4.29e-01
Signaling by ERBB2 ECD mutants 15 2.60e-01 -0.168000 5.79e-01
Response to elevated platelet cytosolic Ca2+ 110 2.33e-03 -0.168000 4.36e-02
Activation of G protein gated Potassium channels 20 1.94e-01 -0.168000 5.07e-01
G protein gated Potassium channels 20 1.94e-01 -0.168000 5.07e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 1.94e-01 -0.168000 5.07e-01
Synthesis of pyrophosphates in the cytosol 8 4.11e-01 0.168000 6.95e-01
Interleukin-27 signaling 11 3.36e-01 -0.168000 6.42e-01
RND2 GTPase cycle 37 7.83e-02 0.167000 3.28e-01
Signaling by Insulin receptor 63 2.18e-02 -0.167000 1.65e-01
DNA Double-Strand Break Repair 137 7.63e-04 0.167000 2.27e-02
Anti-inflammatory response favouring Leishmania parasite infection 132 1.04e-03 0.165000 2.60e-02
Leishmania parasite growth and survival 132 1.04e-03 0.165000 2.60e-02
Synthesis of 5-eicosatetraenoic acids 7 4.49e-01 -0.165000 7.35e-01
Nuclear events stimulated by ALK signaling in cancer 33 1.01e-01 0.165000 3.73e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 1.01e-04 0.165000 5.92e-03
GRB2 events in EGFR signaling 11 3.44e-01 -0.165000 6.46e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 1.12e-01 -0.165000 3.91e-01
Amino acid transport across the plasma membrane 26 1.46e-01 -0.165000 4.39e-01
Elastic fibre formation 33 1.02e-01 0.165000 3.75e-01
Regulation of APC/C activators between G1/S and early anaphase 68 1.92e-02 -0.164000 1.54e-01
Erythropoietin activates RAS 13 3.07e-01 -0.164000 6.23e-01
Signaling by FGFR1 42 6.69e-02 -0.163000 3.06e-01
mRNA Splicing - Major Pathway 203 6.08e-05 -0.163000 4.75e-03
Gamma-carboxylation of protein precursors 6 4.89e-01 0.163000 7.69e-01
Organic cation transport 8 4.25e-01 -0.163000 7.10e-01
Organic cation/anion/zwitterion transport 8 4.25e-01 -0.163000 7.10e-01
Signaling by PDGFRA extracellular domain mutants 12 3.30e-01 -0.163000 6.42e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.30e-01 -0.163000 6.42e-01
Potential therapeutics for SARS 149 6.29e-04 0.162000 1.99e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.60e-01 0.162000 4.61e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.60e-01 0.162000 4.61e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.60e-01 0.162000 4.61e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.60e-01 0.162000 4.61e-01
SUMOylation of chromatin organization proteins 57 3.46e-02 0.162000 2.11e-01
Regulation of actin dynamics for phagocytic cup formation 123 1.95e-03 0.162000 3.89e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 3.55e-01 0.161000 6.52e-01
Hedgehog ‘off’ state 91 7.95e-03 -0.161000 8.90e-02
Gap junction trafficking 28 1.41e-01 -0.161000 4.33e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 4.56e-02 -0.160000 2.46e-01
Regulation of endogenous retroelements 92 7.97e-03 0.160000 8.90e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 5.36e-01 -0.160000 7.95e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 5.36e-01 -0.160000 7.95e-01
Rev-mediated nuclear export of HIV RNA 35 1.02e-01 0.160000 3.76e-01
Assembly Of The HIV Virion 15 2.85e-01 -0.159000 6.05e-01
COPI-mediated anterograde transport 92 8.22e-03 -0.159000 9.08e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 5.06e-03 0.159000 6.85e-02
GDP-fucose biosynthesis 6 5.01e-01 0.159000 7.75e-01
Transcriptional Regulation by VENTX 39 8.65e-02 0.159000 3.41e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 2.44e-01 0.159000 5.60e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.63e-01 -0.158000 6.57e-01
Interleukin-17 signaling 68 2.39e-02 -0.158000 1.71e-01
Sodium/Calcium exchangers 9 4.12e-01 -0.158000 6.95e-01
Paracetamol ADME 19 2.34e-01 0.158000 5.45e-01
Thromboxane signalling through TP receptor 20 2.22e-01 -0.158000 5.38e-01
Heme biosynthesis 13 3.25e-01 0.158000 6.38e-01
Downstream signaling of activated FGFR1 22 2.04e-01 -0.157000 5.16e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.52e-01 -0.156000 4.50e-01
GABA receptor activation 38 9.56e-02 -0.156000 3.64e-01
Nef Mediated CD8 Down-regulation 7 4.74e-01 -0.156000 7.59e-01
mRNA Splicing 211 9.28e-05 -0.156000 5.74e-03
InlB-mediated entry of Listeria monocytogenes into host cell 12 3.50e-01 -0.156000 6.49e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 6.86e-02 0.155000 3.08e-01
Signaling by MET 68 2.72e-02 -0.155000 1.83e-01
Nuclear import of Rev protein 34 1.18e-01 0.155000 3.98e-01
FRS-mediated FGFR1 signaling 15 3.02e-01 -0.154000 6.19e-01
MET activates RAS signaling 10 3.99e-01 -0.154000 6.84e-01
SUMO is proteolytically processed 6 5.14e-01 0.154000 7.84e-01
Signaling by EGFR in Cancer 23 2.02e-01 -0.154000 5.13e-01
Heme degradation 11 3.80e-01 -0.153000 6.72e-01
Cohesin Loading onto Chromatin 10 4.03e-01 -0.153000 6.88e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 3.80e-01 -0.153000 6.72e-01
Signaling by PDGFR in disease 19 2.51e-01 -0.152000 5.68e-01
Acyl chain remodelling of PG 11 3.84e-01 -0.152000 6.77e-01
Sialic acid metabolism 28 1.67e-01 0.151000 4.69e-01
Digestion and absorption 7 4.92e-01 -0.150000 7.69e-01
RIPK1-mediated regulated necrosis 31 1.49e-01 -0.150000 4.43e-01
Regulation of necroptotic cell death 31 1.49e-01 -0.150000 4.43e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.33e-01 -0.150000 6.42e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.26e-01 -0.150000 4.15e-01
p75NTR signals via NF-kB 15 3.16e-01 -0.150000 6.33e-01
Wax and plasmalogen biosynthesis 5 5.63e-01 -0.149000 8.13e-01
Mucopolysaccharidoses 11 3.92e-01 0.149000 6.80e-01
Activation of SMO 13 3.52e-01 0.149000 6.52e-01
Sulfur amino acid metabolism 23 2.17e-01 0.149000 5.32e-01
Sphingolipid catabolism 11 3.93e-01 -0.149000 6.80e-01
Transcriptional regulation by small RNAs 61 4.48e-02 0.149000 2.43e-01
Beta-oxidation of pristanoyl-CoA 9 4.41e-01 0.148000 7.27e-01
Fanconi Anemia Pathway 36 1.24e-01 0.148000 4.12e-01
Calcineurin activates NFAT 9 4.42e-01 -0.148000 7.27e-01
Signaling by Hedgehog 120 5.17e-03 -0.148000 6.89e-02
ADP signalling through P2Y purinoceptor 1 21 2.41e-01 -0.148000 5.55e-01
FGFR1b ligand binding and activation 5 5.68e-01 -0.148000 8.15e-01
EPH-Ephrin signaling 81 2.19e-02 -0.147000 1.65e-01
Homologous DNA Pairing and Strand Exchange 43 9.48e-02 0.147000 3.63e-01
Constitutive Signaling by EGFRvIII 14 3.40e-01 -0.147000 6.42e-01
Signaling by EGFRvIII in Cancer 14 3.40e-01 -0.147000 6.42e-01
Neurotransmitter clearance 6 5.32e-01 -0.147000 7.95e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.27e-01 -0.147000 4.17e-01
Signaling by TGFBR3 39 1.13e-01 0.147000 3.91e-01
Zinc transporters 12 3.80e-01 -0.146000 6.72e-01
Activation of gene expression by SREBF (SREBP) 42 1.01e-01 0.146000 3.73e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 5.71e-01 0.146000 8.17e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 7.18e-02 -0.146000 3.17e-01
Diseases associated with O-glycosylation of proteins 50 7.52e-02 0.145000 3.21e-01
PKR-mediated signaling 67 3.96e-02 -0.145000 2.28e-01
Diseases of DNA repair 51 7.29e-02 0.145000 3.18e-01
Amyloid fiber formation 52 7.02e-02 -0.145000 3.14e-01
DNA Double Strand Break Response 47 8.53e-02 0.145000 3.40e-01
RNA Polymerase II Transcription Termination 66 4.18e-02 -0.145000 2.36e-01
IRE1alpha activates chaperones 46 8.92e-02 -0.145000 3.45e-01
G1/S DNA Damage Checkpoints 54 6.57e-02 -0.145000 3.02e-01
Transcriptional regulation of pluripotent stem cells 21 2.52e-01 -0.145000 5.68e-01
Smooth Muscle Contraction 34 1.45e-01 -0.144000 4.37e-01
FCGR3A-mediated phagocytosis 121 6.18e-03 0.144000 7.69e-02
Leishmania phagocytosis 121 6.18e-03 0.144000 7.69e-02
Parasite infection 121 6.18e-03 0.144000 7.69e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 76 3.00e-02 -0.144000 1.96e-01
Defective RIPK1-mediated regulated necrosis 7 5.10e-01 0.144000 7.81e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.91e-01 0.143000 6.79e-01
Negative regulation of MAPK pathway 42 1.09e-01 -0.143000 3.84e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.27e-01 -0.143000 5.38e-01
Lysosphingolipid and LPA receptors 11 4.14e-01 0.142000 6.97e-01
Peroxisomal lipid metabolism 27 2.01e-01 0.142000 5.13e-01
Collagen biosynthesis and modifying enzymes 48 8.89e-02 0.142000 3.45e-01
Cytosolic sensors of pathogen-associated DNA 63 5.16e-02 -0.142000 2.58e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 5.16e-01 0.142000 7.87e-01
Fibronectin matrix formation 6 5.48e-01 0.142000 8.05e-01
Cytochrome P450 - arranged by substrate type 38 1.32e-01 -0.141000 4.24e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 3.62e-01 0.141000 6.56e-01
G2/M DNA replication checkpoint 5 5.86e-01 0.141000 8.24e-01
SHC1 events in EGFR signaling 12 3.99e-01 -0.141000 6.84e-01
Macroautophagy 128 6.00e-03 -0.141000 7.68e-02
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.24e-01 0.141000 4.12e-01
Respiratory syncytial virus (RSV) attachment and entry 18 3.04e-01 -0.140000 6.21e-01
Deadenylation of mRNA 22 2.56e-01 -0.140000 5.73e-01
Interleukin-6 family signaling 20 2.80e-01 0.140000 6.02e-01
DNA Repair 289 4.41e-05 0.140000 3.70e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 5.94e-02 -0.140000 2.84e-01
Maturation of spike protein 9683686 5 5.89e-01 0.139000 8.25e-01
IL-6-type cytokine receptor ligand interactions 13 3.85e-01 0.139000 6.78e-01
Cytosolic sulfonation of small molecules 18 3.07e-01 -0.139000 6.23e-01
Reversal of alkylation damage by DNA dioxygenases 7 5.24e-01 0.139000 7.91e-01
Protein ubiquitination 71 4.32e-02 -0.139000 2.39e-01
DCC mediated attractive signaling 13 3.87e-01 -0.139000 6.78e-01
Autophagy 142 4.52e-03 -0.138000 6.52e-02
Unblocking of NMDA receptors, glutamate binding and activation 16 3.39e-01 0.138000 6.42e-01
Metabolism of water-soluble vitamins and cofactors 115 1.06e-02 0.138000 1.06e-01
Synaptic adhesion-like molecules 17 3.25e-01 0.138000 6.38e-01
Glycogen storage diseases 13 3.90e-01 -0.138000 6.79e-01
Signaling by FGFR2 61 6.27e-02 -0.138000 2.95e-01
Formation of ATP by chemiosmotic coupling 20 2.86e-01 -0.138000 6.07e-01
Base-Excision Repair, AP Site Formation 29 1.99e-01 0.138000 5.13e-01
Transport of the SLBP Dependant Mature mRNA 36 1.53e-01 0.138000 4.50e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 5.29e-01 -0.137000 7.94e-01
Cell surface interactions at the vascular wall 176 1.68e-03 0.137000 3.58e-02
Phase I - Functionalization of compounds 70 4.71e-02 -0.137000 2.50e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 1.54e-01 -0.137000 4.53e-01
Vitamin D (calciferol) metabolism 11 4.32e-01 0.137000 7.17e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 4.93e-02 -0.137000 2.56e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 4.21e-03 0.137000 6.31e-02
Signaling by ALK 24 2.47e-01 0.136000 5.63e-01
Iron uptake and transport 52 8.87e-02 -0.136000 3.45e-01
Nephrin family interactions 20 2.91e-01 -0.136000 6.14e-01
Condensation of Prophase Chromosomes 27 2.21e-01 0.136000 5.36e-01
Synthesis of PIPs at the early endosome membrane 16 3.46e-01 0.136000 6.47e-01
Signaling by LTK 10 4.57e-01 0.136000 7.40e-01
FGFR2 ligand binding and activation 9 4.81e-01 0.136000 7.64e-01
RHO GTPases activate PKNs 46 1.13e-01 -0.135000 3.91e-01
Vitamin B5 (pantothenate) metabolism 20 2.97e-01 0.135000 6.18e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.03e-01 -0.134000 5.14e-01
Transport of the SLBP independent Mature mRNA 35 1.70e-01 0.134000 4.72e-01
Meiotic recombination 37 1.58e-01 0.134000 4.60e-01
Axon guidance 459 8.56e-07 -0.134000 1.18e-04
Amino acids regulate mTORC1 48 1.09e-01 -0.134000 3.83e-01
APOBEC3G mediated resistance to HIV-1 infection 5 6.04e-01 0.134000 8.33e-01
Role of ABL in ROBO-SLIT signaling 6 5.71e-01 -0.134000 8.17e-01
G beta:gamma signalling through PI3Kgamma 22 2.78e-01 -0.134000 6.01e-01
Defective B4GALT7 causes EDS, progeroid type 11 4.44e-01 0.133000 7.28e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 1.66e-01 0.133000 4.68e-01
Beta-catenin independent WNT signaling 126 9.86e-03 -0.133000 1.00e-01
Metabolism of fat-soluble vitamins 28 2.24e-01 0.133000 5.38e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 2.70e-01 0.133000 5.91e-01
Unfolded Protein Response (UPR) 84 3.56e-02 -0.133000 2.14e-01
Activation of Matrix Metalloproteinases 22 2.82e-01 0.132000 6.03e-01
Regulation of beta-cell development 22 2.84e-01 -0.132000 6.04e-01
Transport of RCbl within the body 8 5.18e-01 -0.132000 7.87e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 1.07e-01 0.132000 3.83e-01
APC/C-mediated degradation of cell cycle proteins 75 4.85e-02 -0.132000 2.54e-01
Regulation of mitotic cell cycle 75 4.85e-02 -0.132000 2.54e-01
rRNA modification in the nucleus and cytosol 59 8.02e-02 -0.132000 3.30e-01
Phospholipase C-mediated cascade: FGFR1 8 5.19e-01 -0.132000 7.88e-01
Glutamate Neurotransmitter Release Cycle 20 3.09e-01 0.131000 6.24e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.37e-01 0.131000 4.29e-01
Regulation of RUNX1 Expression and Activity 18 3.36e-01 0.131000 6.42e-01
Signaling by Retinoic Acid 29 2.23e-01 0.131000 5.38e-01
Gastrulation 76 4.87e-02 -0.131000 2.54e-01
trans-Golgi Network Vesicle Budding 69 6.07e-02 -0.131000 2.90e-01
The NLRP3 inflammasome 16 3.68e-01 0.130000 6.63e-01
Cation-coupled Chloride cotransporters 6 5.82e-01 0.130000 8.22e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 5.00e-01 0.130000 7.75e-01
ER Quality Control Compartment (ERQC) 21 3.04e-01 -0.130000 6.21e-01
SUMOylation of ubiquitinylation proteins 39 1.62e-01 0.129000 4.64e-01
Vitamin C (ascorbate) metabolism 8 5.29e-01 0.129000 7.94e-01
Protein folding 83 4.30e-02 -0.129000 2.39e-01
Chaperonin-mediated protein folding 77 5.13e-02 -0.128000 2.58e-01
ROS and RNS production in phagocytes 30 2.24e-01 -0.128000 5.38e-01
E2F mediated regulation of DNA replication 22 2.97e-01 0.128000 6.18e-01
tRNA processing in the nucleus 59 8.95e-02 0.128000 3.45e-01
Interleukin-21 signaling 9 5.07e-01 0.128000 7.78e-01
Amine ligand-binding receptors 10 4.84e-01 0.128000 7.66e-01
Interactions of Rev with host cellular proteins 37 1.79e-01 0.128000 4.82e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 3.36e-01 0.127000 6.42e-01
Triglyceride metabolism 26 2.61e-01 -0.127000 5.80e-01
Neurofascin interactions 5 6.23e-01 -0.127000 8.41e-01
Late SARS-CoV-2 Infection Events 64 8.02e-02 -0.126000 3.30e-01
Early SARS-CoV-2 Infection Events 31 2.23e-01 -0.126000 5.38e-01
Telomere Extension By Telomerase 23 2.94e-01 -0.126000 6.15e-01
RNA Polymerase III Chain Elongation 18 3.54e-01 -0.126000 6.52e-01
Aquaporin-mediated transport 38 1.79e-01 -0.126000 4.82e-01
MAPK3 (ERK1) activation 10 4.90e-01 -0.126000 7.69e-01
Maternal to zygotic transition (MZT) 72 6.46e-02 -0.126000 2.99e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.55e-01 0.126000 6.52e-01
Cellular response to chemical stress 179 3.69e-03 -0.126000 6.00e-02
Dual Incision in GG-NER 41 1.64e-01 0.126000 4.65e-01
Recycling of eIF2:GDP 8 5.38e-01 -0.126000 7.97e-01
TRAF6 mediated NF-kB activation 23 2.97e-01 0.126000 6.18e-01
Signaling by NTRK2 (TRKB) 20 3.34e-01 -0.125000 6.42e-01
SHC-mediated cascade:FGFR4 11 4.74e-01 -0.125000 7.59e-01
Metabolism of vitamins and cofactors 166 5.57e-03 0.125000 7.32e-02
Signaling by BMP 23 3.01e-01 0.125000 6.19e-01
RAF/MAP kinase cascade 226 1.27e-03 -0.124000 2.93e-02
Interleukin-7 signaling 21 3.24e-01 -0.124000 6.37e-01
Regulation of TP53 Activity through Methylation 19 3.48e-01 0.124000 6.48e-01
Extra-nuclear estrogen signaling 67 7.91e-02 -0.124000 3.30e-01
Gap junction trafficking and regulation 30 2.41e-01 -0.124000 5.55e-01
NADE modulates death signalling 5 6.32e-01 -0.124000 8.41e-01
Processing of Intronless Pre-mRNAs 20 3.39e-01 -0.123000 6.42e-01
Transcriptional activation of mitochondrial biogenesis 52 1.24e-01 0.123000 4.12e-01
Assembly of the ORC complex at the origin of replication 23 3.06e-01 0.123000 6.23e-01
Signal transduction by L1 20 3.40e-01 -0.123000 6.42e-01
Pexophagy 10 5.01e-01 0.123000 7.75e-01
Dopamine Neurotransmitter Release Cycle 20 3.41e-01 0.123000 6.44e-01
Ethanol oxidation 8 5.48e-01 0.123000 8.05e-01
Effects of PIP2 hydrolysis 24 2.98e-01 0.123000 6.18e-01
Prostacyclin signalling through prostacyclin receptor 16 3.96e-01 -0.123000 6.83e-01
C-type lectin receptors (CLRs) 118 2.16e-02 -0.122000 1.65e-01
activated TAK1 mediates p38 MAPK activation 23 3.11e-01 -0.122000 6.27e-01
Orc1 removal from chromatin 58 1.09e-01 -0.122000 3.83e-01
Receptor Mediated Mitophagy 11 4.85e-01 -0.122000 7.66e-01
Gain-of-function MRAS complexes activate RAF signaling 8 5.51e-01 -0.122000 8.07e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 5.51e-01 -0.122000 8.07e-01
Signaling by MRAS-complex mutants 8 5.51e-01 -0.122000 8.07e-01
Azathioprine ADME 21 3.35e-01 0.122000 6.42e-01
Downstream TCR signaling 89 4.74e-02 -0.122000 2.52e-01
Metabolism of non-coding RNA 53 1.26e-01 0.122000 4.15e-01
snRNP Assembly 53 1.26e-01 0.122000 4.15e-01
Cobalamin (Cbl) metabolism 7 5.80e-01 0.121000 8.22e-01
eNOS activation 12 4.69e-01 -0.121000 7.55e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 6.41e-01 0.121000 8.43e-01
STAT3 nuclear events downstream of ALK signaling 11 4.89e-01 0.121000 7.69e-01
RUNX2 regulates genes involved in cell migration 6 6.09e-01 0.121000 8.35e-01
RNA Polymerase III Transcription Termination 23 3.18e-01 -0.120000 6.33e-01
RMTs methylate histone arginines 35 2.19e-01 0.120000 5.34e-01
Retinoid metabolism and transport 25 2.99e-01 0.120000 6.18e-01
Sema3A PAK dependent Axon repulsion 15 4.21e-01 -0.120000 7.06e-01
Downstream signaling of activated FGFR4 18 3.78e-01 -0.120000 6.72e-01
Signaling by PDGF 50 1.43e-01 -0.120000 4.34e-01
Endogenous sterols 18 3.79e-01 -0.120000 6.72e-01
FLT3 signaling through SRC family kinases 6 6.11e-01 -0.120000 8.36e-01
HDR through Single Strand Annealing (SSA) 37 2.07e-01 0.120000 5.19e-01
Cyclin E associated events during G1/S transition 73 7.71e-02 -0.120000 3.25e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 2.34e-01 -0.120000 5.45e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 1.44e-01 -0.120000 4.34e-01
Programmed Cell Death 187 4.85e-03 -0.119000 6.71e-02
Formation of the nephric duct 8 5.59e-01 -0.119000 8.12e-01
Activated NTRK2 signals through FRS2 and FRS3 8 5.59e-01 -0.119000 8.12e-01
Common Pathway of Fibrin Clot Formation 13 4.57e-01 -0.119000 7.40e-01
Nuclear Envelope Breakdown 53 1.34e-01 0.119000 4.24e-01
Creatine metabolism 6 6.13e-01 0.119000 8.36e-01
Constitutive Signaling by Overexpressed ERBB2 11 4.94e-01 -0.119000 7.71e-01
Glycosphingolipid catabolism 31 2.53e-01 0.119000 5.71e-01
Maturation of spike protein 9694548 36 2.19e-01 -0.118000 5.34e-01
Keratan sulfate biosynthesis 20 3.59e-01 0.118000 6.56e-01
MAPK1/MAPK3 signaling 232 1.89e-03 -0.118000 3.81e-02
Activation of the TFAP2 (AP-2) family of transcription factors 7 5.88e-01 0.118000 8.25e-01
Attenuation phase 23 3.28e-01 -0.118000 6.41e-01
PI3K events in ERBB2 signaling 11 4.99e-01 -0.118000 7.74e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 4.99e-01 -0.118000 7.74e-01
Pre-NOTCH Processing in Golgi 18 3.88e-01 0.118000 6.78e-01
Cell recruitment (pro-inflammatory response) 25 3.11e-01 0.117000 6.27e-01
Purinergic signaling in leishmaniasis infection 25 3.11e-01 0.117000 6.27e-01
Gene Silencing by RNA 87 5.90e-02 0.117000 2.83e-01
Nonhomologous End-Joining (NHEJ) 40 2.00e-01 0.117000 5.13e-01
Costimulation by the CD28 family 74 8.18e-02 0.117000 3.33e-01
Clathrin-mediated endocytosis 128 2.23e-02 -0.117000 1.67e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 3.22e-01 -0.117000 6.36e-01
EPHB-mediated forward signaling 40 2.02e-01 -0.117000 5.13e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.97e-01 0.116000 5.13e-01
Diseases of DNA Double-Strand Break Repair 41 1.97e-01 0.116000 5.13e-01
Cristae formation 33 2.49e-01 -0.116000 5.66e-01
Downregulation of ERBB4 signaling 8 5.72e-01 -0.115000 8.17e-01
Nervous system development 478 1.59e-05 -0.115000 1.54e-03
Vitamin B2 (riboflavin) metabolism 6 6.25e-01 0.115000 8.41e-01
Ubiquinol biosynthesis 13 4.73e-01 0.115000 7.59e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 3.62e-01 -0.115000 6.57e-01
PERK regulates gene expression 30 2.76e-01 -0.115000 5.99e-01
Interleukin-37 signaling 19 3.87e-01 -0.115000 6.78e-01
TICAM1-dependent activation of IRF3/IRF7 13 4.76e-01 -0.114000 7.60e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 6.59e-01 0.114000 8.52e-01
SUMOylation 167 1.11e-02 0.114000 1.08e-01
FLT3 signaling by CBL mutants 7 6.02e-01 -0.114000 8.33e-01
Cytosolic tRNA aminoacylation 24 3.35e-01 -0.114000 6.42e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.08e-03 -0.114000 2.66e-02
Notch-HLH transcription pathway 28 2.98e-01 0.114000 6.18e-01
Cell-cell junction organization 60 1.29e-01 0.113000 4.21e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 2.41e-01 0.113000 5.55e-01
Toll Like Receptor 3 (TLR3) Cascade 104 4.69e-02 -0.113000 2.50e-01
Activation of GABAB receptors 31 2.77e-01 -0.113000 6.00e-01
GABA B receptor activation 31 2.77e-01 -0.113000 6.00e-01
Phospholipase C-mediated cascade; FGFR2 8 5.81e-01 0.113000 8.22e-01
Regulation of HMOX1 expression and activity 5 6.64e-01 -0.112000 8.54e-01
ERKs are inactivated 13 4.83e-01 -0.112000 7.66e-01
SUMOylation of DNA damage response and repair proteins 77 8.95e-02 0.112000 3.45e-01
FGFR1c ligand binding and activation 8 5.84e-01 -0.112000 8.24e-01
SUMO E3 ligases SUMOylate target proteins 161 1.46e-02 0.112000 1.30e-01
XBP1(S) activates chaperone genes 44 2.01e-01 -0.111000 5.13e-01
Maturation of protein 3a 9683673 9 5.63e-01 0.111000 8.13e-01
Maturation of protein 3a 9694719 9 5.63e-01 0.111000 8.13e-01
Regulation of TP53 Expression and Degradation 36 2.48e-01 -0.111000 5.64e-01
G beta:gamma signalling through CDC42 17 4.28e-01 -0.111000 7.13e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 2.08e-01 0.111000 5.20e-01
OAS antiviral response 8 5.88e-01 -0.111000 8.25e-01
SUMOylation of RNA binding proteins 47 1.90e-01 0.111000 5.03e-01
Trafficking and processing of endosomal TLR 13 4.90e-01 0.110000 7.69e-01
Signaling by FGFR4 in disease 11 5.26e-01 -0.110000 7.93e-01
Urea cycle 7 6.13e-01 -0.110000 8.36e-01
Cell junction organization 82 8.42e-02 0.110000 3.38e-01
Apoptotic cleavage of cell adhesion proteins 8 5.89e-01 -0.110000 8.25e-01
Sensory Perception 197 7.68e-03 -0.110000 8.73e-02
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 3.05e-01 -0.110000 6.22e-01
Arachidonate metabolism 45 2.02e-01 -0.110000 5.13e-01
MASTL Facilitates Mitotic Progression 10 5.47e-01 -0.110000 8.05e-01
Pre-NOTCH Transcription and Translation 47 1.93e-01 0.110000 5.07e-01
FGFR2 alternative splicing 25 3.42e-01 -0.110000 6.45e-01
Blood group systems biosynthesis 18 4.21e-01 -0.110000 7.06e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 3.53e-01 0.109000 6.52e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 3.53e-01 0.109000 6.52e-01
Golgi-to-ER retrograde transport 123 3.64e-02 -0.109000 2.17e-01
ERK/MAPK targets 22 3.78e-01 -0.109000 6.72e-01
FGFR3 ligand binding and activation 5 6.74e-01 -0.109000 8.60e-01
FGFR3c ligand binding and activation 5 6.74e-01 -0.109000 8.60e-01
MAPK family signaling cascades 264 2.42e-03 -0.108000 4.49e-02
Metabolism of cofactors 25 3.49e-01 0.108000 6.48e-01
TCR signaling 110 4.99e-02 -0.108000 2.57e-01
Protein-protein interactions at synapses 61 1.44e-01 0.108000 4.34e-01
MET activates PTK2 signaling 23 3.70e-01 -0.108000 6.66e-01
Apoptosis 158 1.93e-02 -0.108000 1.54e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.28e-01 0.107000 5.38e-01
Deactivation of the beta-catenin transactivating complex 36 2.66e-01 0.107000 5.86e-01
Packaging Of Telomere Ends 18 4.33e-01 0.107000 7.17e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 5.05e-01 -0.107000 7.77e-01
Cleavage of the damaged pyrimidine 27 3.38e-01 0.107000 6.42e-01
Depyrimidination 27 3.38e-01 0.107000 6.42e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 3.38e-01 0.107000 6.42e-01
TRAF6 mediated IRF7 activation 15 4.75e-01 0.107000 7.60e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.77e-01 0.107000 6.72e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 3.88e-01 -0.106000 6.78e-01
Synthesis of Dolichyl-phosphate 6 6.52e-01 -0.106000 8.49e-01
MyD88-independent TLR4 cascade 108 5.68e-02 -0.106000 2.74e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 5.68e-02 -0.106000 2.74e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 4.92e-01 0.106000 7.69e-01
Adenylate cyclase activating pathway 8 6.04e-01 0.106000 8.33e-01
Semaphorin interactions 56 1.70e-01 -0.106000 4.72e-01
CD28 dependent PI3K/Akt signaling 22 3.91e-01 0.106000 6.79e-01
Abacavir ADME 5 6.84e-01 -0.105000 8.65e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 2.28e-01 -0.105000 5.38e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.95e-01 -0.105000 6.82e-01
Regulation of expression of SLITs and ROBOs 149 2.72e-02 -0.105000 1.83e-01
Aspirin ADME 16 4.69e-01 -0.105000 7.55e-01
Linoleic acid (LA) metabolism 7 6.32e-01 0.104000 8.41e-01
Inhibition of Signaling by Overexpressed EGFR 6 6.58e-01 -0.104000 8.52e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 6.58e-01 -0.104000 8.52e-01
Intraflagellar transport 47 2.19e-01 0.104000 5.34e-01
Ribosomal scanning and start codon recognition 58 1.72e-01 -0.104000 4.73e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 5.92e-01 0.103000 8.28e-01
PIWI-interacting RNA (piRNA) biogenesis 23 3.96e-01 0.102000 6.83e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 4.96e-01 -0.102000 7.71e-01
Lysine catabolism 11 5.59e-01 0.102000 8.12e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 4.43e-01 -0.102000 7.28e-01
PLC beta mediated events 40 2.67e-01 0.101000 5.86e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.80e-01 0.101000 6.03e-01
Extension of Telomeres 51 2.12e-01 0.101000 5.26e-01
Interaction between L1 and Ankyrins 26 3.72e-01 -0.101000 6.68e-01
PDH complex synthesizes acetyl-CoA from PYR 5 6.96e-01 -0.101000 8.70e-01
RHOJ GTPase cycle 50 2.18e-01 -0.101000 5.34e-01
Translation initiation complex formation 58 1.85e-01 -0.101000 4.96e-01
Antiviral mechanism by IFN-stimulated genes 140 4.03e-02 -0.100000 2.29e-01
Keratan sulfate/keratin metabolism 28 3.58e-01 0.100000 6.56e-01
NS1 Mediated Effects on Host Pathways 40 2.73e-01 0.100000 5.96e-01
Respiratory Syncytial Virus Infection Pathway 99 8.53e-02 -0.100000 3.40e-01
Signaling by TGF-beta Receptor Complex 91 9.90e-02 -0.100000 3.71e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 6.72e-01 -0.099900 8.60e-01
TGFBR1 KD Mutants in Cancer 6 6.72e-01 -0.099900 8.60e-01
Signaling by Erythropoietin 24 3.98e-01 -0.099700 6.84e-01
GRB2 events in ERBB2 signaling 11 5.67e-01 -0.099700 8.15e-01
Bacterial Infection Pathways 66 1.62e-01 -0.099600 4.64e-01
Nuclear Envelope (NE) Reassembly 68 1.56e-01 -0.099600 4.55e-01
Collagen formation 66 1.62e-01 0.099600 4.64e-01
Initiation of Nuclear Envelope (NE) Reformation 19 4.55e-01 -0.099100 7.38e-01
Apoptotic execution phase 46 2.46e-01 -0.098900 5.61e-01
Cytoprotection by HMOX1 53 2.14e-01 -0.098700 5.29e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 4.81e-01 -0.098700 7.64e-01
Signaling by Interleukins 391 8.19e-04 -0.098600 2.32e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 5.55e-01 0.098400 8.09e-01
p75NTR recruits signalling complexes 12 5.55e-01 -0.098300 8.09e-01
Other semaphorin interactions 16 4.96e-01 -0.098300 7.71e-01
Cyclin A:Cdk2-associated events at S phase entry 75 1.42e-01 -0.098100 4.33e-01
Signaling by WNT 241 8.86e-03 -0.097900 9.46e-02
UCH proteinases 73 1.48e-01 -0.097900 4.43e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 1.17e-01 -0.097800 3.98e-01
Host Interactions of HIV factors 118 6.78e-02 -0.097300 3.08e-01
FRS-mediated FGFR4 signaling 13 5.44e-01 -0.097300 8.02e-01
ADORA2B mediated anti-inflammatory cytokines production 36 3.14e-01 -0.097000 6.30e-01
PI Metabolism 79 1.36e-01 0.096900 4.29e-01
Transcriptional regulation of granulopoiesis 44 2.66e-01 0.096900 5.86e-01
Formation of definitive endoderm 9 6.15e-01 -0.096800 8.38e-01
Signaling by ROBO receptors 189 2.25e-02 -0.096200 1.68e-01
Integration of provirus 9 6.18e-01 -0.096100 8.39e-01
VxPx cargo-targeting to cilium 19 4.70e-01 -0.095700 7.56e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.95e-01 0.095500 7.71e-01
Defective B3GAT3 causes JDSSDHD 11 5.85e-01 0.095100 8.24e-01
tRNA modification in the nucleus and cytosol 43 2.81e-01 0.095100 6.03e-01
Insulin receptor signalling cascade 40 2.98e-01 -0.095000 6.18e-01
PI-3K cascade:FGFR2 13 5.53e-01 -0.095000 8.09e-01
Regulation of BACH1 activity 11 5.86e-01 -0.094900 8.24e-01
Signaling by Activin 14 5.40e-01 -0.094700 7.99e-01
Glucagon signaling in metabolic regulation 26 4.04e-01 -0.094500 6.88e-01
CREB3 factors activate genes 6 6.89e-01 -0.094300 8.67e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.99e-01 0.094300 5.13e-01
Impaired BRCA2 binding to RAD51 35 3.35e-01 0.094200 6.42e-01
Apoptotic cleavage of cellular proteins 35 3.36e-01 -0.094000 6.42e-01
ER to Golgi Anterograde Transport 145 5.09e-02 -0.093900 2.58e-01
Defective C1GALT1C1 causes TNPS 10 6.09e-01 0.093500 8.35e-01
Nucleotide catabolism 28 3.92e-01 -0.093500 6.80e-01
Triglyceride catabolism 16 5.17e-01 -0.093500 7.87e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.14e-01 -0.093400 5.29e-01
p38MAPK events 13 5.60e-01 -0.093300 8.12e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 4.93e-01 0.093300 7.70e-01
Glucose metabolism 76 1.60e-01 0.093200 4.61e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 4.40e-01 0.093100 7.25e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.09e-01 0.093000 5.21e-01
IRF3-mediated induction of type I IFN 12 5.78e-01 -0.092700 8.21e-01
Peroxisomal protein import 58 2.23e-01 0.092600 5.38e-01
CD28 dependent Vav1 pathway 12 5.80e-01 0.092300 8.22e-01
Advanced glycosylation endproduct receptor signaling 12 5.80e-01 -0.092300 8.22e-01
HDL assembly 6 6.96e-01 0.092000 8.70e-01
Transport and synthesis of PAPS 6 6.97e-01 -0.091800 8.70e-01
SLC transporter disorders 77 1.64e-01 0.091700 4.65e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 5.69e-01 0.091200 8.17e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.70e-01 0.091000 4.72e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 7.25e-01 0.091000 8.88e-01
Transcriptional regulation by RUNX2 92 1.32e-01 -0.090900 4.24e-01
Pentose phosphate pathway 13 5.71e-01 -0.090700 8.17e-01
Signaling by BRAF and RAF1 fusions 60 2.25e-01 -0.090600 5.38e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.20e-01 0.090600 8.39e-01
Post-translational modification: synthesis of GPI-anchored proteins 59 2.30e-01 0.090400 5.39e-01
Regulation of pyruvate metabolism 32 3.77e-01 -0.090300 6.72e-01
Diseases of mitotic cell cycle 38 3.36e-01 0.090200 6.42e-01
PI3K/AKT activation 8 6.59e-01 -0.090200 8.52e-01
Translation of Structural Proteins 9683701 29 4.01e-01 -0.090100 6.85e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 3.19e-02 -0.090000 2.01e-01
Branched-chain amino acid catabolism 21 4.75e-01 0.090000 7.60e-01
G-protein mediated events 44 3.02e-01 0.089900 6.19e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 2.82e-01 0.089700 6.03e-01
Diseases of branched-chain amino acid catabolism 13 5.75e-01 0.089700 8.18e-01
RNA Polymerase I Promoter Opening 17 5.23e-01 0.089600 7.91e-01
Regulation of signaling by NODAL 6 7.04e-01 0.089600 8.74e-01
Transcriptional regulation by RUNX1 170 4.45e-02 -0.089300 2.42e-01
VEGFA-VEGFR2 Pathway 93 1.41e-01 -0.088400 4.33e-01
Signaling by ERBB2 44 3.11e-01 -0.088300 6.27e-01
Cargo recognition for clathrin-mediated endocytosis 89 1.51e-01 -0.088100 4.47e-01
MyD88 cascade initiated on plasma membrane 95 1.38e-01 -0.088100 4.29e-01
Toll Like Receptor 10 (TLR10) Cascade 95 1.38e-01 -0.088100 4.29e-01
Toll Like Receptor 5 (TLR5) Cascade 95 1.38e-01 -0.088100 4.29e-01
Acyl chain remodelling of PC 19 5.07e-01 -0.087800 7.78e-01
N-glycan trimming and elongation in the cis-Golgi 5 7.34e-01 0.087700 8.88e-01
p75NTR negatively regulates cell cycle via SC1 5 7.34e-01 -0.087600 8.88e-01
Metabolism of amine-derived hormones 10 6.32e-01 -0.087600 8.41e-01
RHOG GTPase cycle 71 2.02e-01 -0.087500 5.13e-01
Cell-extracellular matrix interactions 16 5.45e-01 -0.087400 8.04e-01
Ca2+ activated K+ channels 6 7.11e-01 0.087300 8.79e-01
Sensing of DNA Double Strand Breaks 6 7.13e-01 0.086700 8.80e-01
Inositol phosphate metabolism 42 3.31e-01 0.086700 6.42e-01
Senescence-Associated Secretory Phenotype (SASP) 65 2.27e-01 -0.086700 5.38e-01
TCF dependent signaling in response to WNT 153 6.46e-02 -0.086600 2.99e-01
Phase 0 - rapid depolarisation 24 4.63e-01 -0.086500 7.47e-01
Pausing and recovery of Tat-mediated HIV elongation 30 4.12e-01 0.086500 6.95e-01
Tat-mediated HIV elongation arrest and recovery 30 4.12e-01 0.086500 6.95e-01
Regulation of TP53 Degradation 35 3.77e-01 -0.086200 6.72e-01
Striated Muscle Contraction 27 4.39e-01 -0.086000 7.25e-01
Signaling by FGFR 73 2.05e-01 -0.085900 5.17e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 7.16e-01 -0.085700 8.81e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 6.39e-01 0.085700 8.43e-01
Transcriptional Regulation by MECP2 49 3.00e-01 0.085700 6.18e-01
Ribavirin ADME 11 6.23e-01 0.085600 8.41e-01
Activated point mutants of FGFR2 7 6.95e-01 0.085500 8.69e-01
RHOQ GTPase cycle 55 2.74e-01 -0.085200 5.97e-01
Formation of the Early Elongation Complex 33 3.99e-01 0.084900 6.84e-01
Formation of the HIV-1 Early Elongation Complex 33 3.99e-01 0.084900 6.84e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 6.59e-01 0.084800 8.52e-01
Peptide hormone metabolism 54 2.81e-01 -0.084700 6.03e-01
Class I MHC mediated antigen processing & presentation 344 6.92e-03 -0.084700 8.31e-02
Membrane Trafficking 577 5.05e-04 -0.084700 1.74e-02
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.94e-01 -0.084500 6.81e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 4.66e-01 0.084300 7.50e-01
Signaling by Non-Receptor Tyrosine Kinases 47 3.18e-01 -0.084200 6.33e-01
Signaling by PTK6 47 3.18e-01 -0.084200 6.33e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 5.86e-01 -0.084100 8.24e-01
WNT ligand biogenesis and trafficking 19 5.26e-01 -0.084000 7.93e-01
Metabolism of RNA 718 1.26e-04 -0.084000 6.60e-03
Glyoxylate metabolism and glycine degradation 13 6.00e-01 0.083900 8.33e-01
Formation of WDR5-containing histone-modifying complexes 42 3.47e-01 0.083900 6.47e-01
B-WICH complex positively regulates rRNA expression 45 3.30e-01 -0.083900 6.42e-01
FCERI mediated NF-kB activation 129 1.00e-01 0.083800 3.73e-01
Recognition of DNA damage by PCNA-containing replication complex 30 4.27e-01 0.083800 7.12e-01
NOD1/2 Signaling Pathway 36 3.85e-01 -0.083600 6.78e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 6.82e-01 0.083600 8.65e-01
Insulin processing 19 5.28e-01 -0.083600 7.94e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 7.23e-01 -0.083500 8.87e-01
FGFR1 ligand binding and activation 10 6.48e-01 -0.083300 8.48e-01
Interleukin-23 signaling 7 7.03e-01 0.083100 8.73e-01
Leishmania infection 211 3.76e-02 0.083000 2.21e-01
Parasitic Infection Pathways 211 3.76e-02 0.083000 2.21e-01
Assembly of active LPL and LIPC lipase complexes 10 6.50e-01 -0.083000 8.48e-01
Dual incision in TC-NER 63 2.55e-01 0.082900 5.73e-01
Signaling by ERBB2 in Cancer 21 5.11e-01 -0.082800 7.83e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.32e-01 -0.082700 4.24e-01
Metalloprotease DUBs 20 5.22e-01 -0.082600 7.91e-01
Purine salvage 12 6.21e-01 0.082400 8.40e-01
GPER1 signaling 38 3.80e-01 -0.082300 6.72e-01
MyD88 deficiency (TLR2/4) 14 5.95e-01 0.082000 8.31e-01
Termination of translesion DNA synthesis 32 4.22e-01 0.081900 7.08e-01
TRP channels 22 5.06e-01 0.081900 7.77e-01
Negative regulation of the PI3K/AKT network 93 1.74e-01 -0.081600 4.74e-01
ERBB2 Activates PTK6 Signaling 8 6.90e-01 0.081400 8.67e-01
Defects in cobalamin (B12) metabolism 13 6.12e-01 0.081400 8.36e-01
RET signaling 32 4.27e-01 -0.081200 7.12e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.99e-01 0.081100 5.13e-01
ISG15 antiviral mechanism 72 2.35e-01 -0.081000 5.46e-01
Diseases of glycosylation 109 1.45e-01 0.080700 4.37e-01
RIP-mediated NFkB activation via ZBP1 17 5.65e-01 -0.080600 8.13e-01
Cellular responses to mechanical stimuli 82 2.07e-01 -0.080600 5.19e-01
Response of endothelial cells to shear stress 82 2.07e-01 -0.080600 5.19e-01
STING mediated induction of host immune responses 15 5.89e-01 -0.080600 8.25e-01
Ub-specific processing proteases 153 8.56e-02 -0.080500 3.40e-01
Mitochondrial calcium ion transport 22 5.13e-01 -0.080500 7.84e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 3.93e-01 0.080100 6.80e-01
Nucleosome assembly 38 3.93e-01 0.080100 6.80e-01
Class A/1 (Rhodopsin-like receptors) 175 6.84e-02 -0.079900 3.08e-01
Cargo trafficking to the periciliary membrane 47 3.47e-01 0.079400 6.47e-01
Interleukin-2 signaling 11 6.49e-01 -0.079300 8.48e-01
Cilium Assembly 186 6.22e-02 0.079300 2.94e-01
IRAK4 deficiency (TLR2/4) 15 5.95e-01 0.079200 8.31e-01
Telomere Maintenance 78 2.30e-01 0.078700 5.39e-01
Translesion synthesis by POLI 17 5.75e-01 0.078600 8.18e-01
Signaling by Leptin 10 6.67e-01 -0.078600 8.56e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 3.36e-01 0.078600 6.42e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 7.00e-01 -0.078600 8.72e-01
HS-GAG biosynthesis 20 5.43e-01 -0.078600 8.02e-01
Bicarbonate transporters 9 6.84e-01 0.078300 8.65e-01
AMPK inhibits chREBP transcriptional activation activity 6 7.40e-01 -0.078100 8.91e-01
Glutamate and glutamine metabolism 12 6.40e-01 0.078100 8.43e-01
HIV Infection 213 4.96e-02 -0.078000 2.56e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 6.26e-01 -0.078000 8.41e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 4.84e-01 0.077900 7.66e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.84e-01 0.077900 7.66e-01
Heme signaling 45 3.66e-01 0.077900 6.62e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.37e-01 -0.077800 6.42e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 7.42e-01 -0.077700 8.92e-01
Synthesis of substrates in N-glycan biosythesis 59 3.02e-01 0.077700 6.19e-01
Nucleotide Excision Repair 108 1.63e-01 0.077700 4.65e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 5.29e-01 -0.077500 7.94e-01
Separation of Sister Chromatids 168 8.35e-02 -0.077400 3.36e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 6.30e-01 -0.077100 8.41e-01
N-Glycan antennae elongation 13 6.31e-01 0.077000 8.41e-01
Germ layer formation at gastrulation 9 6.90e-01 -0.076700 8.67e-01
Pre-NOTCH Expression and Processing 63 2.94e-01 0.076500 6.15e-01
Nitric oxide stimulates guanylate cyclase 15 6.08e-01 0.076400 8.35e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 7.27e-01 -0.076100 8.88e-01
Zygotic genome activation (ZGA) 5 7.69e-01 0.075900 9.09e-01
RNA Polymerase I Transcription Initiation 47 3.71e-01 0.075400 6.68e-01
Membrane binding and targetting of GAG proteins 13 6.39e-01 -0.075200 8.43e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 6.39e-01 -0.075200 8.43e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 5.43e-01 -0.074900 8.02e-01
Chromosome Maintenance 103 1.90e-01 0.074700 5.03e-01
Nuclear signaling by ERBB4 24 5.26e-01 0.074700 7.93e-01
Recycling of bile acids and salts 10 6.83e-01 0.074700 8.65e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.52e-01 0.074600 8.96e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.52e-01 0.074600 8.96e-01
IRAK2 mediated activation of TAK1 complex 10 6.84e-01 -0.074300 8.65e-01
Evasion by RSV of host interferon responses 20 5.65e-01 -0.074300 8.13e-01
Regulated Necrosis 56 3.36e-01 -0.074300 6.42e-01
Chromatin modifying enzymes 215 6.10e-02 0.074100 2.90e-01
Chromatin organization 215 6.10e-02 0.074100 2.90e-01
Interleukin-4 and Interleukin-13 signaling 93 2.17e-01 -0.074100 5.32e-01
Regulation of TP53 Activity through Acetylation 29 4.91e-01 0.073900 7.69e-01
Formation of annular gap junctions 10 6.86e-01 0.073900 8.66e-01
Regulation of CDH19 Expression and Function 6 7.54e-01 0.073900 8.97e-01
CASP8 activity is inhibited 11 6.73e-01 0.073500 8.60e-01
Dimerization of procaspase-8 11 6.73e-01 0.073500 8.60e-01
Regulation by c-FLIP 11 6.73e-01 0.073500 8.60e-01
Apoptosis induced DNA fragmentation 10 6.87e-01 -0.073500 8.67e-01
RAB GEFs exchange GTP for GDP on RABs 89 2.32e-01 -0.073400 5.42e-01
Disorders of transmembrane transporters 137 1.38e-01 -0.073300 4.29e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 6.60e-01 0.073300 8.52e-01
alpha-linolenic acid (ALA) metabolism 12 6.60e-01 0.073300 8.52e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.35e-01 0.073200 8.42e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.35e-01 0.073200 8.42e-01
PTK6 promotes HIF1A stabilization 6 7.56e-01 -0.073100 8.98e-01
PKA activation 15 6.24e-01 -0.073100 8.41e-01
Signalling to RAS 19 5.81e-01 -0.073100 8.22e-01
FGFRL1 modulation of FGFR1 signaling 7 7.38e-01 -0.073000 8.91e-01
Synthesis of PIPs at the plasma membrane 52 3.63e-01 0.072900 6.57e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.91e-01 -0.072800 5.03e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 1.91e-01 -0.072800 5.03e-01
Mitotic Anaphase 211 6.83e-02 -0.072800 3.08e-01
G beta:gamma signalling through PLC beta 17 6.04e-01 -0.072700 8.33e-01
Presynaptic function of Kainate receptors 17 6.04e-01 -0.072700 8.33e-01
Receptor-type tyrosine-protein phosphatases 12 6.63e-01 -0.072700 8.54e-01
Myogenesis 21 5.64e-01 -0.072700 8.13e-01
Constitutive Signaling by Aberrant PI3K in Cancer 59 3.36e-01 -0.072500 6.42e-01
Switching of origins to a post-replicative state 79 2.65e-01 -0.072500 5.86e-01
SHC1 events in ERBB2 signaling 17 6.05e-01 -0.072400 8.33e-01
mRNA Splicing - Minor Pathway 50 3.77e-01 -0.072200 6.72e-01
G alpha (q) signalling events 139 1.42e-01 -0.072200 4.33e-01
Mitotic Metaphase and Anaphase 212 7.06e-02 -0.072000 3.15e-01
Processing of DNA double-strand break ends 69 3.01e-01 0.072000 6.19e-01
Depolymerization of the Nuclear Lamina 15 6.30e-01 -0.071900 8.41e-01
FLT3 Signaling 38 4.43e-01 -0.071800 7.28e-01
RAB geranylgeranylation 61 3.32e-01 -0.071800 6.42e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 4.14e-02 -0.071400 2.34e-01
Drug ADME 59 3.43e-01 0.071300 6.46e-01
Downstream signal transduction 27 5.22e-01 -0.071100 7.91e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.84e-01 0.070900 8.65e-01
TRAIL signaling 8 7.29e-01 0.070800 8.88e-01
Glycosaminoglycan metabolism 98 2.26e-01 0.070800 5.38e-01
Retrograde neurotrophin signalling 12 6.72e-01 0.070700 8.60e-01
Aspartate and asparagine metabolism 9 7.14e-01 0.070700 8.80e-01
TP53 Regulates Metabolic Genes 78 2.81e-01 -0.070500 6.03e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.60e-01 0.070500 8.52e-01
DNA Damage Bypass 47 4.04e-01 0.070400 6.88e-01
Regulation of IFNA/IFNB signaling 12 6.73e-01 -0.070300 8.60e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 6.61e-01 -0.070200 8.52e-01
HCMV Early Events 84 2.67e-01 0.070100 5.86e-01
Transport to the Golgi and subsequent modification 171 1.14e-01 -0.070000 3.92e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 3.67e-01 -0.069700 6.63e-01
Negative regulation of FLT3 15 6.41e-01 0.069600 8.43e-01
RHO GTPases activate CIT 18 6.10e-01 -0.069400 8.36e-01
FGFR2 mutant receptor activation 23 5.65e-01 0.069400 8.13e-01
FOXO-mediated transcription 58 3.61e-01 -0.069400 6.56e-01
Fatty acid metabolism 155 1.36e-01 0.069400 4.29e-01
Generic Transcription Pathway 1088 1.14e-04 0.069300 6.32e-03
Interleukin-10 signaling 38 4.60e-01 -0.069200 7.44e-01
Asparagine N-linked glycosylation 286 4.46e-02 -0.069000 2.42e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 1.75e-02 -0.068900 1.46e-01
HCMV Late Events 67 3.31e-01 0.068700 6.42e-01
Signaling by FGFR1 in disease 32 5.01e-01 -0.068700 7.75e-01
O-glycosylation of TSR domain-containing proteins 28 5.29e-01 0.068700 7.94e-01
Condensation of Prometaphase Chromosomes 11 6.94e-01 0.068500 8.69e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 7.72e-01 0.068400 9.10e-01
MyD88 dependent cascade initiated on endosome 101 2.35e-01 -0.068400 5.46e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 5.32e-01 -0.068300 7.95e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 5.98e-01 0.068100 8.33e-01
Adipogenesis 96 2.50e-01 0.068000 5.66e-01
Signaling by KIT in disease 20 5.99e-01 -0.067800 8.33e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 5.99e-01 -0.067800 8.33e-01
CaM pathway 28 5.35e-01 0.067700 7.95e-01
Calmodulin induced events 28 5.35e-01 0.067700 7.95e-01
Signaling by NTRKs 117 2.07e-01 -0.067500 5.19e-01
Protein hydroxylation 17 6.31e-01 -0.067400 8.41e-01
RNA Polymerase I Transcription Termination 30 5.23e-01 -0.067300 7.91e-01
Nef Mediated CD4 Down-regulation 9 7.27e-01 -0.067300 8.88e-01
Toll Like Receptor 2 (TLR2) Cascade 109 2.26e-01 -0.067200 5.38e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 2.26e-01 -0.067200 5.38e-01
Miscellaneous transport and binding events 20 6.03e-01 -0.067200 8.33e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 7.00e-01 0.067000 8.72e-01
Signaling by ERBB2 KD Mutants 20 6.04e-01 -0.066900 8.33e-01
CaMK IV-mediated phosphorylation of CREB 9 7.28e-01 -0.066900 8.88e-01
Mitotic Telophase/Cytokinesis 13 6.77e-01 0.066800 8.61e-01
RHOV GTPase cycle 36 4.88e-01 0.066700 7.69e-01
HIV elongation arrest and recovery 32 5.14e-01 0.066700 7.84e-01
Pausing and recovery of HIV elongation 32 5.14e-01 0.066700 7.84e-01
Sphingolipid metabolism 91 2.74e-01 -0.066300 5.97e-01
Apoptotic factor-mediated response 19 6.19e-01 -0.065900 8.39e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 6.38e-01 0.065900 8.43e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 2.56e-01 -0.065700 5.73e-01
rRNA processing 213 9.83e-02 -0.065700 3.70e-01
Nucleotide salvage 21 6.02e-01 0.065700 8.33e-01
Neurotransmitter release cycle 38 4.85e-01 0.065400 7.67e-01
Diseases of Mismatch Repair (MMR) 5 8.00e-01 0.065400 9.25e-01
TNFR1-induced proapoptotic signaling 24 5.81e-01 0.065100 8.22e-01
Plasma lipoprotein clearance 33 5.18e-01 0.065100 7.87e-01
Developmental Biology 929 7.76e-04 -0.065000 2.27e-02
Signaling by SCF-KIT 40 4.77e-01 -0.065000 7.60e-01
Formation of Incision Complex in GG-NER 43 4.62e-01 -0.064800 7.47e-01
Organelle biogenesis and maintenance 277 6.36e-02 0.064800 2.96e-01
G alpha (i) signalling events 194 1.20e-01 -0.064700 4.04e-01
Mitotic Prophase 96 2.73e-01 0.064700 5.96e-01
SARS-CoV-1 Infection 138 1.90e-01 -0.064600 5.03e-01
Biosynthesis of maresin-like SPMs 5 8.03e-01 -0.064500 9.27e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 4.91e-01 -0.064500 7.69e-01
Mitochondrial translation termination 90 2.91e-01 -0.064500 6.14e-01
Glycosphingolipid metabolism 46 4.50e-01 0.064300 7.37e-01
Signaling by ERBB4 45 4.56e-01 -0.064200 7.40e-01
Mitochondrial translation initiation 90 2.93e-01 -0.064200 6.15e-01
Neutrophil degranulation 458 1.86e-02 -0.064200 1.52e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 6.32e-01 0.063600 8.41e-01
Dectin-2 family 19 6.32e-01 -0.063500 8.41e-01
Oncogenic MAPK signaling 76 3.39e-01 -0.063500 6.42e-01
Post NMDA receptor activation events 64 3.80e-01 -0.063400 6.72e-01
FLT3 signaling in disease 27 5.70e-01 -0.063100 8.17e-01
PECAM1 interactions 12 7.06e-01 -0.063000 8.75e-01
Signaling by Receptor Tyrosine Kinases 449 2.30e-02 -0.062600 1.71e-01
Downstream signaling of activated FGFR2 20 6.28e-01 -0.062500 8.41e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 4.07e-01 -0.062400 6.91e-01
NGF-stimulated transcription 32 5.42e-01 0.062300 8.02e-01
Signaling by NTRK3 (TRKC) 16 6.66e-01 0.062300 8.56e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.76e-01 0.062200 8.18e-01
Mitochondrial translation 96 2.94e-01 -0.062000 6.15e-01
FGFR4 ligand binding and activation 5 8.10e-01 -0.061900 9.31e-01
Phase 4 - resting membrane potential 9 7.48e-01 0.061900 8.96e-01
Signaling by NOTCH3 44 4.78e-01 -0.061800 7.60e-01
Transport of fatty acids 5 8.11e-01 0.061600 9.31e-01
Metabolism of carbohydrates 241 9.99e-02 0.061500 3.73e-01
Cargo concentration in the ER 31 5.54e-01 -0.061400 8.09e-01
Sensory perception of taste 22 6.18e-01 -0.061400 8.39e-01
DAG and IP3 signaling 34 5.36e-01 0.061400 7.95e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 6.53e-01 0.061100 8.50e-01
Opioid Signalling 75 3.60e-01 -0.061100 6.56e-01
Regulation of NF-kappa B signaling 18 6.54e-01 -0.061000 8.50e-01
Oxidative Stress Induced Senescence 77 3.55e-01 0.060900 6.52e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 6.13e-01 -0.060900 8.36e-01
Loss of Function of TGFBR1 in Cancer 7 7.81e-01 -0.060800 9.14e-01
Regulation of lipid metabolism by PPARalpha 107 2.78e-01 0.060600 6.01e-01
RAF-independent MAPK1/3 activation 22 6.23e-01 -0.060600 8.41e-01
Cytokine Signaling in Immune system 670 7.75e-03 -0.060300 8.75e-02
HATs acetylate histones 92 3.18e-01 -0.060300 6.33e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 2.86e-01 -0.060200 6.07e-01
Complex I biogenesis 66 3.99e-01 -0.060000 6.84e-01
RUNX2 regulates osteoblast differentiation 21 6.34e-01 0.060000 8.42e-01
Biological oxidations 146 2.13e-01 -0.059700 5.28e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 7.70e-01 -0.059700 9.09e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 5.24e-01 0.059700 7.91e-01
Translation 293 7.97e-02 -0.059500 3.30e-01
RUNX2 regulates bone development 26 5.99e-01 0.059500 8.33e-01
EGFR Transactivation by Gastrin 7 7.85e-01 -0.059500 9.18e-01
Extracellular matrix organization 222 1.28e-01 0.059300 4.20e-01
Processing and activation of SUMO 10 7.46e-01 0.059200 8.95e-01
Interferon Signaling 240 1.14e-01 -0.059200 3.92e-01
Centrosome maturation 81 3.59e-01 0.058900 6.56e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.59e-01 0.058900 6.56e-01
TYSND1 cleaves peroxisomal proteins 7 7.87e-01 0.058900 9.19e-01
Biosynthesis of DHA-derived SPMs 15 6.93e-01 0.058900 8.69e-01
Basigin interactions 23 6.25e-01 -0.058900 8.41e-01
Reproduction 85 3.48e-01 0.058800 6.48e-01
Platelet homeostasis 69 3.98e-01 -0.058800 6.84e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 4.51e-01 0.058800 7.37e-01
G alpha (s) signalling events 97 3.18e-01 0.058700 6.33e-01
Caspase activation via Death Receptors in the presence of ligand 16 6.85e-01 0.058700 8.65e-01
Mitochondrial translation elongation 90 3.37e-01 -0.058600 6.42e-01
ZBP1(DAI) mediated induction of type I IFNs 20 6.50e-01 -0.058600 8.48e-01
WNT mediated activation of DVL 8 7.75e-01 0.058400 9.12e-01
Signaling by NTRK1 (TRKA) 102 3.08e-01 -0.058400 6.24e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 4.96e-01 -0.058100 7.71e-01
Metabolism of Angiotensinogen to Angiotensins 12 7.28e-01 0.058000 8.88e-01
Assembly and cell surface presentation of NMDA receptors 34 5.58e-01 -0.058000 8.12e-01
Nucleotide-like (purinergic) receptors 13 7.18e-01 0.057900 8.82e-01
RUNX3 Regulates Immune Response and Cell Migration 6 8.06e-01 -0.057800 9.30e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 6.46e-01 0.057800 8.47e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.44e-01 -0.057800 6.46e-01
Cellular responses to stimuli 779 6.19e-03 -0.057700 7.69e-02
CTLA4 inhibitory signaling 21 6.48e-01 -0.057600 8.48e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 8.24e-01 0.057500 9.37e-01
Free fatty acids regulate insulin secretion 10 7.53e-01 0.057500 8.96e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 7.79e-01 0.057400 9.14e-01
APC-Cdc20 mediated degradation of Nek2A 26 6.13e-01 -0.057400 8.36e-01
RUNX3 regulates WNT signaling 8 7.80e-01 0.057100 9.14e-01
SMAC (DIABLO) binds to IAPs 7 7.94e-01 0.056900 9.22e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 7.94e-01 0.056900 9.22e-01
SMAC, XIAP-regulated apoptotic response 7 7.94e-01 0.056900 9.22e-01
PI3K events in ERBB4 signaling 6 8.09e-01 0.056900 9.31e-01
Defensins 8 7.81e-01 -0.056900 9.14e-01
Translesion synthesis by REV1 16 6.94e-01 0.056800 8.69e-01
Toll Like Receptor 4 (TLR4) Cascade 138 2.50e-01 -0.056700 5.66e-01
Muscle contraction 145 2.39e-01 -0.056600 5.53e-01
Stimuli-sensing channels 81 3.79e-01 0.056500 6.72e-01
Synthesis, secretion, and deacylation of Ghrelin 11 7.47e-01 -0.056300 8.95e-01
Plasma lipoprotein assembly 10 7.58e-01 0.056200 9.00e-01
Erythropoietin activates STAT5 6 8.11e-01 -0.056200 9.31e-01
HSF1 activation 26 6.20e-01 -0.056100 8.39e-01
G2/M DNA damage checkpoint 66 4.33e-01 0.055800 7.17e-01
Sensory processing of sound by inner hair cells of the cochlea 54 4.78e-01 0.055800 7.60e-01
Ion transport by P-type ATPases 43 5.27e-01 0.055800 7.93e-01
Signal regulatory protein family interactions 13 7.28e-01 -0.055800 8.88e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 8.13e-01 0.055700 9.31e-01
Tie2 Signaling 16 7.00e-01 -0.055700 8.72e-01
Uptake and function of diphtheria toxin 6 8.13e-01 -0.055700 9.31e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.11e-01 -0.055500 8.36e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 5.34e-01 0.055400 7.95e-01
HIV Transcription Elongation 42 5.34e-01 0.055400 7.95e-01
Tat-mediated elongation of the HIV-1 transcript 42 5.34e-01 0.055400 7.95e-01
Mitochondrial protein degradation 96 3.49e-01 -0.055300 6.48e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 5.61e-01 0.055200 8.12e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 2.59e-01 -0.055100 5.77e-01
Phase II - Conjugation of compounds 71 4.22e-01 -0.055100 7.08e-01
WNT5A-dependent internalization of FZD4 13 7.31e-01 0.055000 8.88e-01
S Phase 150 2.46e-01 0.054800 5.61e-01
Signaling by FGFR2 IIIa TM 18 6.88e-01 0.054700 8.67e-01
Reduction of cytosolic Ca++ levels 9 7.78e-01 -0.054300 9.14e-01
RNA Polymerase I Promoter Clearance 64 4.53e-01 0.054300 7.38e-01
RNA Polymerase I Transcription 64 4.53e-01 0.054300 7.38e-01
Toll Like Receptor 9 (TLR9) Cascade 108 3.30e-01 -0.054200 6.42e-01
Negative regulators of DDX58/IFIH1 signaling 34 5.87e-01 -0.053800 8.25e-01
Mitochondrial iron-sulfur cluster biogenesis 13 7.37e-01 0.053800 8.90e-01
NRAGE signals death through JNK 52 5.02e-01 0.053800 7.75e-01
Cell-Cell communication 114 3.21e-01 0.053800 6.36e-01
Influenza Viral RNA Transcription and Replication 135 2.84e-01 0.053400 6.04e-01
Dissolution of Fibrin Clot 12 7.49e-01 0.053400 8.96e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 7.94e-01 -0.053400 9.22e-01
Signaling by VEGF 100 3.58e-01 -0.053200 6.56e-01
Signaling by NOTCH2 33 5.98e-01 0.053100 8.33e-01
Xenobiotics 12 7.51e-01 0.052900 8.96e-01
Cellular response to starvation 148 2.67e-01 -0.052900 5.86e-01
Intra-Golgi traffic 43 5.49e-01 -0.052800 8.07e-01
GPCR ligand binding 241 1.59e-01 -0.052700 4.61e-01
PI3K/AKT Signaling in Cancer 85 4.04e-01 -0.052400 6.88e-01
Regulation of TNFR1 signaling 47 5.35e-01 -0.052300 7.95e-01
EPH-ephrin mediated repulsion of cells 43 5.53e-01 0.052300 8.09e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 3.49e-01 0.052100 6.48e-01
TAK1-dependent IKK and NF-kappa-B activation 43 5.56e-01 -0.051900 8.09e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 8.12e-01 0.051900 9.31e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 8.41e-01 0.051900 9.44e-01
Translesion synthesis by POLK 17 7.11e-01 0.051800 8.79e-01
SUMOylation of intracellular receptors 26 6.48e-01 -0.051700 8.48e-01
Meiosis 67 4.65e-01 0.051700 7.49e-01
rRNA processing in the nucleus and cytosol 189 2.21e-01 -0.051600 5.36e-01
Interleukin-20 family signaling 17 7.14e-01 -0.051400 8.80e-01
mRNA Capping 29 6.33e-01 0.051200 8.41e-01
RUNX1 regulates estrogen receptor mediated transcription 6 8.28e-01 -0.051200 9.39e-01
Listeria monocytogenes entry into host cells 17 7.15e-01 -0.051100 8.81e-01
Synthesis of GDP-mannose 6 8.28e-01 0.051100 9.39e-01
Prolactin receptor signaling 12 7.60e-01 -0.051000 9.00e-01
Activated NTRK3 signals through PI3K 5 8.44e-01 -0.050900 9.44e-01
FOXO-mediated transcription of cell cycle genes 15 7.33e-01 -0.050900 8.88e-01
Formation of the beta-catenin:TCF transactivating complex 44 5.60e-01 0.050800 8.12e-01
Tryptophan catabolism 12 7.61e-01 0.050700 9.02e-01
Epigenetic regulation of gene expression 263 1.57e-01 0.050600 4.59e-01
MECP2 regulates neuronal receptors and channels 14 7.43e-01 0.050600 8.93e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 4.53e-01 0.050500 7.38e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 3.59e-01 -0.050400 6.56e-01
tRNA Aminoacylation 42 5.72e-01 0.050400 8.17e-01
Cellular responses to stress 698 2.39e-02 -0.050200 1.71e-01
Serine biosynthesis 8 8.06e-01 -0.050100 9.30e-01
Intrinsic Pathway for Apoptosis 54 5.24e-01 -0.050100 7.91e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 4.37e-01 0.050000 7.22e-01
O-linked glycosylation of mucins 47 5.55e-01 -0.049800 8.09e-01
PI5P Regulates TP53 Acetylation 8 8.08e-01 -0.049600 9.31e-01
Regulation of gene expression in beta cells 8 8.08e-01 -0.049500 9.31e-01
FasL/ CD95L signaling 5 8.49e-01 0.049200 9.47e-01
Processing of Capped Intronless Pre-mRNA 29 6.46e-01 -0.049200 8.47e-01
Diseases associated with the TLR signaling cascade 29 6.47e-01 0.049200 8.47e-01
Diseases of Immune System 29 6.47e-01 0.049200 8.47e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 7.99e-01 -0.048900 9.25e-01
PPARA activates gene expression 105 3.87e-01 0.048800 6.78e-01
Biosynthesis of E-series 18(S)-resolvins 5 8.50e-01 0.048800 9.47e-01
Cell Cycle, Mitotic 488 6.65e-02 0.048500 3.05e-01
Diseases of carbohydrate metabolism 29 6.52e-01 0.048400 8.49e-01
RNA Polymerase II Transcription 1206 4.99e-03 0.048000 6.84e-02
Transport of vitamins, nucleosides, and related molecules 32 6.38e-01 0.048000 8.43e-01
Glycosphingolipid biosynthesis 15 7.49e-01 -0.047700 8.96e-01
SARS-CoV Infections 433 8.96e-02 0.047600 3.45e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 8.28e-01 0.047500 9.39e-01
Downregulation of ERBB2:ERBB3 signaling 12 7.76e-01 -0.047400 9.13e-01
SARS-CoV-1 activates/modulates innate immune responses 40 6.04e-01 0.047400 8.33e-01
Activation of kainate receptors upon glutamate binding 26 6.76e-01 -0.047300 8.61e-01
ECM proteoglycans 48 5.71e-01 -0.047300 8.17e-01
VEGFR2 mediated cell proliferation 18 7.29e-01 0.047100 8.88e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.79e-01 -0.046900 6.01e-01
HSF1-dependent transactivation 30 6.56e-01 -0.046900 8.52e-01
Nephron development 5 8.57e-01 0.046500 9.49e-01
Small interfering RNA (siRNA) biogenesis 9 8.10e-01 -0.046400 9.31e-01
EGFR interacts with phospholipase C-gamma 7 8.32e-01 -0.046400 9.40e-01
Activation of HOX genes during differentiation 70 5.04e-01 0.046200 7.77e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 5.04e-01 0.046200 7.77e-01
RORA activates gene expression 18 7.35e-01 0.046200 8.88e-01
Deubiquitination 225 2.35e-01 -0.045900 5.46e-01
ERBB2 Regulates Cell Motility 10 8.02e-01 -0.045900 9.26e-01
Assembly of the pre-replicative complex 87 4.60e-01 -0.045800 7.44e-01
Cellular Senescence 143 3.45e-01 0.045700 6.46e-01
Gene expression (Transcription) 1413 4.12e-03 0.045500 6.31e-02
SARS-CoV-2-host interactions 183 2.90e-01 0.045400 6.13e-01
Activation of NMDA receptors and postsynaptic events 74 5.06e-01 -0.044700 7.77e-01
Metabolism of nucleotides 85 4.77e-01 0.044600 7.60e-01
Vitamin B1 (thiamin) metabolism 5 8.63e-01 -0.044400 9.51e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.23e-01 -0.044200 7.08e-01
Defective Intrinsic Pathway for Apoptosis 24 7.09e-01 0.044000 8.79e-01
Defective B3GALTL causes PpS 27 6.94e-01 0.043700 8.69e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 7.12e-01 -0.043600 8.79e-01
Complex IV assembly 45 6.16e-01 -0.043200 8.38e-01
Collagen chain trimerization 29 6.87e-01 0.043200 8.67e-01
Pyruvate metabolism 44 6.20e-01 -0.043200 8.39e-01
Synthesis of DNA 108 4.39e-01 0.043100 7.25e-01
TNFR2 non-canonical NF-kB pathway 84 4.95e-01 -0.043100 7.71e-01
Mitotic G2-G2/M phases 179 3.22e-01 -0.042900 6.36e-01
Cell Cycle 611 7.12e-02 0.042700 3.16e-01
Postmitotic nuclear pore complex (NPC) reformation 27 7.02e-01 0.042500 8.73e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 6.26e-01 0.042400 8.41e-01
G2/M Transition 177 3.33e-01 -0.042200 6.42e-01
FGFR1 mutant receptor activation 25 7.15e-01 -0.042100 8.81e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 4.89e-01 0.042000 7.69e-01
Amplification of signal from the kinetochores 91 4.89e-01 0.042000 7.69e-01
P2Y receptors 10 8.18e-01 0.042000 9.34e-01
Cap-dependent Translation Initiation 118 4.31e-01 -0.041900 7.17e-01
Eukaryotic Translation Initiation 118 4.31e-01 -0.041900 7.17e-01
PIP3 activates AKT signaling 235 2.70e-01 -0.041800 5.90e-01
SIRT1 negatively regulates rRNA expression 22 7.35e-01 0.041700 8.88e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 8.29e-01 0.041500 9.39e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 4.44e-01 -0.041500 7.28e-01
Nonsense-Mediated Decay (NMD) 114 4.44e-01 -0.041500 7.28e-01
Synthesis of diphthamide-EEF2 8 8.39e-01 -0.041400 9.44e-01
Processing of SMDT1 15 7.82e-01 0.041200 9.16e-01
DNA Replication 128 4.23e-01 0.041000 7.08e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 7.84e-01 -0.040900 9.17e-01
SUMOylation of transcription cofactors 44 6.39e-01 -0.040900 8.43e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 5.31e-01 -0.040800 7.95e-01
TGF-beta receptor signaling activates SMADs 45 6.37e-01 -0.040700 8.43e-01
Neddylation 215 3.04e-01 -0.040700 6.21e-01
STAT5 Activation 7 8.52e-01 -0.040600 9.47e-01
Androgen biosynthesis 5 8.75e-01 0.040500 9.58e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 7.28e-01 -0.040300 8.88e-01
Heparan sulfate/heparin (HS-GAG) metabolism 40 6.60e-01 0.040200 8.52e-01
Anchoring of the basal body to the plasma membrane 97 4.96e-01 0.040000 7.71e-01
NCAM1 interactions 27 7.20e-01 0.039800 8.85e-01
Interleukin-2 family signaling 38 6.73e-01 0.039600 8.60e-01
ChREBP activates metabolic gene expression 7 8.57e-01 -0.039400 9.49e-01
Rab regulation of trafficking 122 4.54e-01 -0.039300 7.38e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 8.25e-01 0.038600 9.37e-01
Synthesis of UDP-N-acetyl-glucosamine 8 8.51e-01 0.038300 9.47e-01
Ephrin signaling 18 7.79e-01 0.038200 9.14e-01
Phospholipid metabolism 183 3.77e-01 0.037900 6.72e-01
RAC3 GTPase cycle 88 5.48e-01 -0.037000 8.05e-01
Transcriptional Regulation by NPAS4 27 7.39e-01 -0.037000 8.91e-01
SARS-CoV-1 modulates host translation machinery 36 7.02e-01 -0.036900 8.73e-01
Signaling by Nuclear Receptors 214 3.54e-01 0.036800 6.52e-01
Mitotic Prometaphase 193 3.79e-01 0.036700 6.72e-01
Lewis blood group biosynthesis 14 8.12e-01 -0.036700 9.31e-01
TNFR1-induced NF-kappa-B signaling pathway 32 7.21e-01 -0.036400 8.85e-01
Protein localization 157 4.31e-01 0.036400 7.17e-01
NOTCH2 intracellular domain regulates transcription 11 8.35e-01 0.036400 9.42e-01
IRS-related events triggered by IGF1R 37 7.02e-01 -0.036300 8.73e-01
Signaling by NOTCH 175 4.07e-01 -0.036300 6.91e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 8.68e-01 -0.036300 9.53e-01
Degradation of the extracellular matrix 99 5.33e-01 0.036300 7.95e-01
Voltage gated Potassium channels 26 7.49e-01 0.036200 8.96e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 7.33e-01 -0.036000 8.88e-01
FGFR2c ligand binding and activation 5 8.89e-01 -0.036000 9.62e-01
Butyrophilin (BTN) family interactions 9 8.52e-01 -0.035900 9.47e-01
Collagen degradation 44 6.80e-01 -0.035900 8.64e-01
Elevation of cytosolic Ca2+ levels 13 8.23e-01 0.035800 9.37e-01
SUMOylation of immune response proteins 12 8.30e-01 0.035700 9.39e-01
Visual phototransduction 60 6.33e-01 -0.035700 8.41e-01
SHC-mediated cascade:FGFR2 13 8.24e-01 -0.035600 9.37e-01
MTOR signalling 39 7.03e-01 0.035300 8.73e-01
AURKA Activation by TPX2 72 6.05e-01 0.035200 8.33e-01
Transport of Mature Transcript to Cytoplasm 81 5.85e-01 -0.035100 8.24e-01
TNF signaling 56 6.51e-01 -0.035000 8.48e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 8.16e-01 -0.034700 9.33e-01
RHO GTPase Effectors 258 3.40e-01 -0.034500 6.42e-01
G alpha (12/13) signalling events 68 6.26e-01 -0.034200 8.41e-01
RNA polymerase II transcribes snRNA genes 71 6.19e-01 -0.034200 8.39e-01
Transcriptional regulation of white adipocyte differentiation 77 6.05e-01 0.034100 8.33e-01
Chondroitin sulfate biosynthesis 12 8.38e-01 -0.034100 9.44e-01
Mitochondrial biogenesis 91 5.74e-01 0.034100 8.18e-01
Integrin cell surface interactions 68 6.27e-01 0.034000 8.41e-01
Diseases of metabolism 208 4.10e-01 0.033200 6.94e-01
Cardiac conduction 89 5.93e-01 -0.032800 8.28e-01
Synthesis of PA 31 7.52e-01 0.032800 8.96e-01
Uptake and actions of bacterial toxins 28 7.64e-01 0.032800 9.03e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 7.78e-01 0.032600 9.14e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 1.66e-01 -0.032500 4.68e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 6.75e-01 0.032400 8.60e-01
Signal Transduction 2058 1.62e-02 -0.032100 1.41e-01
IGF1R signaling cascade 38 7.32e-01 -0.032100 8.88e-01
Metabolism of proteins 1777 2.60e-02 -0.031800 1.81e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 6.41e-01 -0.031800 8.43e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 8.77e-01 0.031700 9.58e-01
RNA Polymerase II Pre-transcription Events 77 6.32e-01 -0.031600 8.41e-01
Beta-oxidation of very long chain fatty acids 11 8.56e-01 0.031600 9.49e-01
Regulation of TP53 Activity through Phosphorylation 88 6.09e-01 0.031600 8.35e-01
ESR-mediated signaling 160 4.92e-01 -0.031500 7.69e-01
CLEC7A/inflammasome pathway 6 8.94e-01 0.031400 9.64e-01
Sensory processing of sound by outer hair cells of the cochlea 41 7.28e-01 -0.031400 8.88e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 7.87e-01 0.031300 9.19e-01
Signaling by Rho GTPases 608 1.89e-01 -0.031200 5.03e-01
tRNA processing 128 5.46e-01 0.030900 8.05e-01
Miscellaneous substrates 7 8.88e-01 -0.030900 9.62e-01
Post-translational protein phosphorylation 70 6.55e-01 -0.030800 8.52e-01
G1/S Transition 120 5.61e-01 0.030700 8.12e-01
Interleukin-9 signaling 8 8.81e-01 0.030700 9.59e-01
Mitochondrial unfolded protein response (UPRmt) 17 8.28e-01 -0.030500 9.39e-01
Intracellular signaling by second messengers 268 3.90e-01 -0.030500 6.79e-01
ALK mutants bind TKIs 11 8.62e-01 -0.030300 9.51e-01
Glycolysis 68 6.66e-01 0.030200 8.56e-01
Transport of nucleotide sugars 9 8.76e-01 -0.030000 9.58e-01
Vesicle-mediated transport 669 1.86e-01 -0.030000 4.97e-01
Signaling by MAPK mutants 6 8.99e-01 -0.029900 9.64e-01
Phosphorylation of the APC/C 20 8.19e-01 0.029600 9.34e-01
RNA Polymerase III Abortive And Retractive Initiation 41 7.45e-01 -0.029400 8.94e-01
RNA Polymerase III Transcription 41 7.45e-01 -0.029400 8.94e-01
Inhibition of DNA recombination at telomere 33 7.73e-01 0.029100 9.10e-01
Glucagon-type ligand receptors 20 8.22e-01 0.029000 9.37e-01
Protein methylation 15 8.47e-01 0.028800 9.46e-01
Negative epigenetic regulation of rRNA expression 63 6.93e-01 0.028800 8.69e-01
SARS-CoV-1-host interactions 95 6.31e-01 -0.028500 8.41e-01
Toll-like Receptor Cascades 162 5.32e-01 -0.028500 7.95e-01
Metabolism of porphyrins 23 8.13e-01 0.028500 9.31e-01
Detoxification of Reactive Oxygen Species 30 7.88e-01 0.028300 9.19e-01
Mitotic Spindle Checkpoint 108 6.12e-01 0.028300 8.36e-01
Estrogen-dependent gene expression 97 6.33e-01 0.028100 8.41e-01
Biosynthesis of maresins 7 8.98e-01 -0.027900 9.64e-01
Biosynthesis of EPA-derived SPMs 6 9.07e-01 -0.027500 9.68e-01
Keratan sulfate degradation 9 8.86e-01 0.027500 9.62e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 8.40e-01 -0.027400 9.44e-01
MicroRNA (miRNA) biogenesis 24 8.17e-01 -0.027300 9.34e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 9.01e-01 0.027100 9.64e-01
RHOC GTPase cycle 72 6.91e-01 0.027100 8.68e-01
CD28 co-stimulation 33 7.88e-01 0.027000 9.19e-01
RHO GTPase cycle 412 3.50e-01 -0.026900 6.48e-01
Ca-dependent events 30 7.99e-01 0.026800 9.25e-01
Synthesis of PIPs at the late endosome membrane 11 8.78e-01 -0.026700 9.59e-01
Signaling by FGFR in disease 52 7.40e-01 0.026600 8.91e-01
NoRC negatively regulates rRNA expression 60 7.23e-01 0.026400 8.87e-01
Respiratory electron transport 149 5.78e-01 -0.026400 8.21e-01
Hydrolysis of LPC 8 8.97e-01 0.026400 9.64e-01
Diseases associated with glycosaminoglycan metabolism 25 8.20e-01 0.026200 9.36e-01
IRS-mediated signalling 35 7.90e-01 -0.026000 9.19e-01
PTEN Regulation 127 6.17e-01 -0.025700 8.38e-01
Meiotic synapsis 43 7.71e-01 0.025700 9.09e-01
Transmission across Chemical Synapses 188 5.53e-01 -0.025100 8.09e-01
RAS signaling downstream of NF1 loss-of-function variants 7 9.09e-01 -0.024900 9.69e-01
Potassium Channels 64 7.31e-01 -0.024900 8.88e-01
Translesion Synthesis by POLH 18 8.56e-01 0.024800 9.49e-01
TBC/RABGAPs 45 7.74e-01 -0.024700 9.12e-01
SHC1 events in ERBB4 signaling 10 8.93e-01 -0.024600 9.64e-01
SLC-mediated transmembrane transport 175 5.75e-01 0.024600 8.18e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 6.80e-01 -0.024600 8.64e-01
Interleukin receptor SHC signaling 23 8.38e-01 0.024600 9.44e-01
Recruitment of NuMA to mitotic centrosomes 88 6.90e-01 0.024600 8.67e-01
Synthesis of IP3 and IP4 in the cytosol 22 8.43e-01 0.024400 9.44e-01
Diseases associated with glycosylation precursor biosynthesis 15 8.70e-01 -0.024300 9.55e-01
cGMP effects 12 8.84e-01 -0.024300 9.62e-01
Class B/2 (Secretin family receptors) 55 7.55e-01 0.024300 8.97e-01
Repression of WNT target genes 14 8.75e-01 0.024200 9.58e-01
Regulation of TP53 Activity 153 6.05e-01 0.024200 8.33e-01
Circadian Clock 67 7.32e-01 -0.024200 8.88e-01
Signaling by NOTCH1 68 7.31e-01 -0.024100 8.88e-01
Transport of small molecules 558 3.34e-01 -0.023900 6.42e-01
Signaling by TGFB family members 139 6.26e-01 -0.023900 8.41e-01
Glycine degradation 7 9.13e-01 -0.023800 9.70e-01
FRS-mediated FGFR2 signaling 15 8.73e-01 -0.023800 9.57e-01
RHO GTPases Activate Formins 128 6.46e-01 0.023500 8.47e-01
Selenoamino acid metabolism 115 6.64e-01 -0.023400 8.55e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 7.71e-01 -0.023400 9.09e-01
Ca2+ pathway 58 7.59e-01 -0.023300 9.00e-01
RNA Polymerase I Promoter Escape 45 7.88e-01 -0.023200 9.19e-01
O-linked glycosylation 85 7.11e-01 0.023200 8.79e-01
Metabolism of lipids 642 3.17e-01 0.023200 6.33e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 8.62e-01 -0.023000 9.51e-01
Immune System 1841 1.03e-01 -0.022900 3.78e-01
Metabolism 1835 1.05e-01 0.022800 3.81e-01
Innate Immune System 971 2.30e-01 -0.022800 5.39e-01
Complex III assembly 23 8.50e-01 0.022700 9.47e-01
MITF-M-regulated melanocyte development 113 6.79e-01 -0.022600 8.63e-01
Acyl chain remodelling of PE 20 8.62e-01 -0.022500 9.51e-01
Trafficking of GluR2-containing AMPA receptors 11 8.97e-01 -0.022500 9.64e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 8.41e-01 -0.022400 9.44e-01
mTORC1-mediated signalling 24 8.51e-01 0.022200 9.47e-01
Plasma lipoprotein remodeling 18 8.71e-01 0.022100 9.55e-01
Mitotic G1 phase and G1/S transition 138 6.57e-01 0.021900 8.52e-01
Regulation of innate immune responses to cytosolic DNA 14 8.88e-01 0.021700 9.62e-01
Formation of a pool of free 40S subunits 100 7.12e-01 -0.021400 8.79e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 6.90e-01 0.021300 8.67e-01
RND1 GTPase cycle 37 8.23e-01 0.021200 9.37e-01
Influenza Infection 154 6.51e-01 0.021100 8.48e-01
Aerobic respiration and respiratory electron transport 245 5.70e-01 -0.021100 8.17e-01
VEGFR2 mediated vascular permeability 26 8.52e-01 0.021100 9.47e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 8.58e-01 0.021000 9.50e-01
Regulation of PTEN mRNA translation 13 8.97e-01 0.020600 9.64e-01
Reactions specific to the complex N-glycan synthesis pathway 7 9.25e-01 -0.020500 9.76e-01
Cellular response to heat stress 94 7.31e-01 -0.020500 8.88e-01
The canonical retinoid cycle in rods (twilight vision) 9 9.16e-01 0.020400 9.71e-01
Regulation of HSF1-mediated heat shock response 79 7.54e-01 -0.020400 8.97e-01
G-protein beta:gamma signalling 29 8.50e-01 -0.020300 9.47e-01
MITF-M-dependent gene expression 83 7.51e-01 0.020200 8.96e-01
Citric acid cycle (TCA cycle) 34 8.41e-01 -0.019900 9.44e-01
Attachment and Entry 9694614 14 8.98e-01 0.019900 9.64e-01
Pyroptosis 25 8.64e-01 0.019700 9.51e-01
RNA Polymerase III Transcription Initiation 36 8.38e-01 -0.019700 9.44e-01
RHO GTPases Activate NADPH Oxidases 21 8.77e-01 -0.019500 9.58e-01
Nuclear Receptor transcription pathway 40 8.32e-01 0.019300 9.40e-01
Establishment of Sister Chromatid Cohesion 11 9.12e-01 -0.019200 9.70e-01
Regulation of NFE2L2 gene expression 8 9.26e-01 -0.019000 9.76e-01
RA biosynthesis pathway 13 9.06e-01 0.019000 9.67e-01
HCMV Infection 106 7.36e-01 0.018900 8.89e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 7.90e-01 -0.018900 9.19e-01
Mitochondrial protein import 63 7.96e-01 -0.018800 9.23e-01
Metabolism of steroids 125 7.18e-01 0.018700 8.82e-01
Activation of caspases through apoptosome-mediated cleavage 6 9.37e-01 -0.018700 9.83e-01
Signaling by GPCR 442 5.05e-01 -0.018500 7.77e-01
Hemostasis 562 4.55e-01 -0.018400 7.38e-01
MECP2 regulates transcription factors 5 9.44e-01 0.018300 9.84e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 9.38e-01 -0.018200 9.83e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 8.44e-01 -0.018200 9.44e-01
M Phase 346 5.64e-01 -0.018100 8.13e-01
Cellular response to mitochondrial stress 9 9.25e-01 -0.018000 9.76e-01
DNA Replication Pre-Initiation 103 7.52e-01 -0.018000 8.96e-01
Formation of the Editosome 6 9.39e-01 0.017900 9.83e-01
mRNA Editing: C to U Conversion 6 9.39e-01 0.017900 9.83e-01
The activation of arylsulfatases 10 9.22e-01 0.017800 9.75e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.97e-01 -0.017600 9.64e-01
Ion homeostasis 42 8.45e-01 0.017500 9.44e-01
Downregulation of ERBB2 signaling 24 8.86e-01 -0.017000 9.62e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 9.13e-01 0.016900 9.70e-01
SLBP independent Processing of Histone Pre-mRNAs 10 9.28e-01 0.016500 9.78e-01
CD209 (DC-SIGN) signaling 20 8.98e-01 0.016500 9.64e-01
Association of TriC/CCT with target proteins during biosynthesis 35 8.66e-01 0.016500 9.52e-01
Sensory processing of sound 58 8.29e-01 0.016400 9.39e-01
Transcriptional Regulation by TP53 346 6.04e-01 0.016200 8.33e-01
Ion channel transport 141 7.40e-01 0.016200 8.91e-01
Antimicrobial peptides 34 8.71e-01 -0.016200 9.55e-01
Nicotinate metabolism 26 8.87e-01 -0.016100 9.62e-01
Synthesis of bile acids and bile salts 27 8.85e-01 -0.016000 9.62e-01
Metabolism of steroid hormones 22 8.97e-01 -0.016000 9.64e-01
Formation of TC-NER Pre-Incision Complex 51 8.44e-01 -0.016000 9.44e-01
Eukaryotic Translation Elongation 93 7.90e-01 0.015900 9.19e-01
Diseases associated with N-glycosylation of proteins 20 9.04e-01 0.015600 9.66e-01
COPII-mediated vesicle transport 67 8.26e-01 -0.015500 9.38e-01
mRNA Editing 8 9.41e-01 0.015200 9.83e-01
GPCR downstream signalling 398 6.06e-01 -0.015100 8.33e-01
Cell Cycle Checkpoints 246 6.84e-01 0.015000 8.65e-01
NCAM signaling for neurite out-growth 48 8.57e-01 -0.015000 9.49e-01
Transcriptional regulation of testis differentiation 5 9.55e-01 -0.014700 9.90e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 8.97e-01 -0.014700 9.64e-01
Integration of energy metabolism 88 8.15e-01 -0.014400 9.33e-01
Signaling by the B Cell Receptor (BCR) 150 7.62e-01 -0.014300 9.02e-01
Adaptive Immune System 768 5.04e-01 -0.014200 7.77e-01
MHC class II antigen presentation 113 7.97e-01 0.014000 9.24e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 8.96e-01 0.014000 9.64e-01
Gap junction degradation 11 9.37e-01 -0.013900 9.83e-01
Signaling by FGFR2 in disease 33 8.91e-01 -0.013800 9.64e-01
Surfactant metabolism 21 9.13e-01 -0.013800 9.70e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 9.09e-01 -0.013700 9.69e-01
Fc epsilon receptor (FCERI) signaling 179 7.51e-01 0.013700 8.96e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 8.14e-01 -0.013700 9.31e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 8.64e-01 -0.013300 9.51e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 8.64e-01 -0.013300 9.51e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 8.64e-01 -0.013300 9.51e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 8.64e-01 -0.013300 9.51e-01
Signaling by NOTCH1 in Cancer 55 8.64e-01 -0.013300 9.51e-01
Thyroxine biosynthesis 5 9.59e-01 0.013300 9.92e-01
Infectious disease 959 4.89e-01 -0.013200 7.69e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 9.22e-01 0.012700 9.75e-01
Trafficking of AMPA receptors 20 9.22e-01 0.012700 9.75e-01
Lysosome Vesicle Biogenesis 32 9.02e-01 -0.012500 9.65e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 8.44e-01 -0.012300 9.44e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 8.44e-01 -0.012300 9.44e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 8.44e-01 -0.012300 9.44e-01
Adenylate cyclase inhibitory pathway 11 9.44e-01 -0.012200 9.84e-01
Death Receptor Signaling 145 8.00e-01 0.012200 9.25e-01
tRNA modification in the mitochondrion 9 9.50e-01 0.012100 9.88e-01
Regulation of KIT signaling 15 9.36e-01 0.012100 9.83e-01
Carboxyterminal post-translational modifications of tubulin 34 9.05e-01 0.011900 9.66e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 9.16e-01 0.011700 9.72e-01
Loss of Function of SMAD2/3 in Cancer 7 9.58e-01 0.011400 9.92e-01
ABC transporters in lipid homeostasis 14 9.42e-01 0.011200 9.84e-01
Post-translational protein modification 1243 5.18e-01 -0.010900 7.87e-01
Activation of BH3-only proteins 30 9.20e-01 -0.010600 9.75e-01
Cell death signalling via NRAGE, NRIF and NADE 69 8.80e-01 0.010500 9.59e-01
Inflammasomes 21 9.34e-01 -0.010400 9.82e-01
Glycerophospholipid biosynthesis 105 8.56e-01 -0.010300 9.49e-01
RHOU GTPase cycle 40 9.11e-01 0.010200 9.70e-01
Nuclear Events (kinase and transcription factor activation) 54 8.97e-01 -0.010100 9.64e-01
2-LTR circle formation 7 9.63e-01 0.010100 9.92e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 9.63e-01 -0.010100 9.92e-01
RSV-host interactions 78 8.81e-01 -0.009790 9.59e-01
Early Phase of HIV Life Cycle 14 9.50e-01 0.009730 9.88e-01
Bile acid and bile salt metabolism 31 9.28e-01 -0.009390 9.78e-01
RAC1 GTPase cycle 173 8.36e-01 0.009150 9.43e-01
DNA Damage Recognition in GG-NER 38 9.24e-01 0.008930 9.76e-01
Peptide chain elongation 88 8.87e-01 0.008800 9.62e-01
Loss of Nlp from mitotic centrosomes 69 9.00e-01 0.008770 9.64e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 9.00e-01 0.008770 9.64e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 9.70e-01 -0.008730 9.92e-01
LDL clearance 18 9.49e-01 -0.008680 9.88e-01
Viral mRNA Translation 88 8.88e-01 -0.008660 9.62e-01
EML4 and NUDC in mitotic spindle formation 107 8.79e-01 -0.008490 9.59e-01
CDC42 GTPase cycle 141 8.63e-01 -0.008430 9.51e-01
Interconversion of nucleotide di- and triphosphates 27 9.40e-01 -0.008300 9.83e-01
Ovarian tumor domain proteases 37 9.31e-01 -0.008200 9.80e-01
Factors involved in megakaryocyte development and platelet production 129 8.73e-01 0.008120 9.57e-01
RHOD GTPase cycle 50 9.22e-01 0.008010 9.75e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 9.54e-01 -0.008010 9.90e-01
FOXO-mediated transcription of cell death genes 16 9.56e-01 0.007920 9.91e-01
RHOB GTPase cycle 65 9.14e-01 0.007750 9.70e-01
Signaling by ALK fusions and activated point mutants 89 9.02e-01 -0.007580 9.64e-01
Signaling by ALK in cancer 89 9.02e-01 -0.007580 9.64e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.52e-01 0.007540 9.89e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.52e-01 0.007540 9.89e-01
Selenocysteine synthesis 92 9.01e-01 0.007500 9.64e-01
Neuronal System 276 8.38e-01 -0.007130 9.44e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 9.69e-01 -0.007070 9.92e-01
Defective EXT2 causes exostoses 2 10 9.69e-01 -0.007070 9.92e-01
Regulation of CDH11 function 10 9.69e-01 -0.007070 9.92e-01
CRMPs in Sema3A signaling 13 9.66e-01 -0.006840 9.92e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 9.62e-01 0.006820 9.92e-01
Eukaryotic Translation Termination 92 9.11e-01 -0.006710 9.70e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 9.76e-01 -0.006640 9.92e-01
Protein lipoylation 10 9.71e-01 -0.006590 9.92e-01
Tight junction interactions 17 9.63e-01 0.006500 9.92e-01
Regulation of insulin secretion 63 9.30e-01 -0.006420 9.79e-01
Viral Infection Pathways 776 7.64e-01 -0.006340 9.03e-01
SARS-CoV-2 modulates host translation machinery 49 9.39e-01 -0.006330 9.83e-01
PKA activation in glucagon signalling 14 9.67e-01 0.006290 9.92e-01
Assembly of collagen fibrils and other multimeric structures 44 9.44e-01 -0.006140 9.84e-01
Regulation of PLK1 Activity at G2/M Transition 87 9.23e-01 -0.005970 9.76e-01
Formation of RNA Pol II elongation complex 56 9.39e-01 -0.005900 9.83e-01
RNA Polymerase II Transcription Elongation 56 9.39e-01 -0.005900 9.83e-01
Oncogene Induced Senescence 33 9.55e-01 -0.005720 9.90e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 9.59e-01 -0.005710 9.92e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.69e-01 -0.005080 9.92e-01
PI3K Cascade 31 9.61e-01 -0.005030 9.92e-01
Metabolism of amino acids and derivatives 308 8.81e-01 -0.004950 9.59e-01
Deadenylation-dependent mRNA decay 50 9.53e-01 0.004810 9.89e-01
PKA-mediated phosphorylation of CREB 17 9.73e-01 0.004730 9.92e-01
Cholesterol biosynthesis 26 9.67e-01 0.004730 9.92e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 9.68e-01 -0.004690 9.92e-01
Activation of RAC1 11 9.79e-01 -0.004650 9.94e-01
Positive epigenetic regulation of rRNA expression 60 9.51e-01 0.004570 9.89e-01
RND3 GTPase cycle 36 9.63e-01 0.004450 9.92e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.76e-01 -0.003850 9.92e-01
Retrograde transport at the Trans-Golgi-Network 49 9.64e-01 -0.003690 9.92e-01
Late Phase of HIV Life Cycle 131 9.42e-01 -0.003680 9.84e-01
Signaling by FLT3 fusion proteins 18 9.79e-01 0.003540 9.94e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 9.85e-01 -0.003360 9.96e-01
Transcription of the HIV genome 67 9.64e-01 -0.003200 9.92e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.81e-01 -0.003110 9.94e-01
p75 NTR receptor-mediated signalling 89 9.61e-01 0.003000 9.92e-01
HIV Transcription Initiation 45 9.73e-01 -0.002950 9.92e-01
RNA Polymerase II HIV Promoter Escape 45 9.73e-01 -0.002950 9.92e-01
RNA Polymerase II Promoter Escape 45 9.73e-01 -0.002950 9.92e-01
RNA Polymerase II Transcription Initiation 45 9.73e-01 -0.002950 9.92e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 9.73e-01 -0.002950 9.92e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 9.73e-01 -0.002950 9.92e-01
SLC15A4:TASL-dependent IRF5 activation 6 9.91e-01 0.002790 9.98e-01
Interleukin-15 signaling 14 9.86e-01 0.002740 9.96e-01
RHOF GTPase cycle 39 9.77e-01 0.002670 9.92e-01
Resolution of Sister Chromatid Cohesion 116 9.62e-01 -0.002590 9.92e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 9.84e-01 -0.002530 9.96e-01
Acyl chain remodeling of CL 5 9.92e-01 0.002490 9.99e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 9.86e-01 0.002160 9.96e-01
Neurodegenerative Diseases 21 9.86e-01 0.002160 9.96e-01
Kinesins 51 9.80e-01 0.001980 9.94e-01
HIV Life Cycle 144 9.68e-01 0.001960 9.92e-01
RAC2 GTPase cycle 86 9.76e-01 -0.001910 9.92e-01
Interferon gamma signaling 90 9.76e-01 0.001800 9.92e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 9.91e-01 -0.001730 9.98e-01
Fatty acyl-CoA biosynthesis 35 9.86e-01 -0.001680 9.96e-01
Cyclin D associated events in G1 47 9.85e-01 -0.001620 9.96e-01
G1 Phase 47 9.85e-01 -0.001620 9.96e-01
G2/M Checkpoints 126 9.76e-01 0.001530 9.92e-01
AKT phosphorylates targets in the cytosol 14 9.92e-01 -0.001460 9.99e-01
TRIF-mediated programmed cell death 9 9.94e-01 -0.001340 9.99e-01
Phospholipase C-mediated cascade; FGFR4 6 9.96e-01 -0.001270 9.99e-01
Disease 1633 9.33e-01 -0.001250 9.81e-01
Interleukin-6 signaling 11 9.95e-01 -0.001080 9.99e-01
Platelet calcium homeostasis 22 9.93e-01 -0.001030 9.99e-01
Signaling by ERBB2 TMD/JMD mutants 17 9.94e-01 -0.001020 9.99e-01
RHOA GTPase cycle 139 9.89e-01 -0.000650 9.98e-01
Activation of Ca-permeable Kainate Receptor 9 9.97e-01 0.000647 9.99e-01
Ionotropic activity of kainate receptors 9 9.97e-01 0.000647 9.99e-01
CLEC7A (Dectin-1) induces NFAT activation 11 9.97e-01 -0.000587 9.99e-01
RHOBTB3 ATPase cycle 10 9.98e-01 0.000491 9.99e-01
Metabolism of folate and pterines 16 9.97e-01 0.000483 9.99e-01
SARS-CoV-2 Infection 267 9.90e-01 -0.000436 9.98e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.99e-01 0.000273 9.99e-01
Pyrimidine salvage 10 9.99e-01 -0.000255 9.99e-01


Detailed Gene set reports



RUNX1 regulates transcription of genes involved in BCR signaling
set RUNX1 regulates transcription of genes involved in BCR signaling
setSize 6
pANOVA 0.000998
s.dist -0.776
p.adjustANOVA 0.0257


Top enriched genes
Top 20 genes
GeneID Gene Rank
BLK -10172
ELF1 -10055
ELF2 -8657
PAX5 -8523
RUNX1 -8245
CBFB -4793

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All member genes
GeneID Gene Rank
BLK -10172
ELF1 -10055
ELF2 -8657
PAX5 -8523
RUNX1 -8245
CBFB -4793


CD163 mediating an anti-inflammatory response
set CD163 mediating an anti-inflammatory response
setSize 9
pANOVA 7.12e-05
s.dist -0.764
p.adjustANOVA 0.00514


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD163 -10868
IL10 -10461
ADAM17 -10103
RHBDF2 -9794
FURIN -8550
PLK2 -7072
IL6 -6500
MYH9 -5965
MAPK14 -5230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD163 -10868
IL10 -10461
ADAM17 -10103
RHBDF2 -9794
FURIN -8550
PLK2 -7072
IL6 -6500
MYH9 -5965
MAPK14 -5230


Formation of xylulose-5-phosphate
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.00685
s.dist 0.698
p.adjustANOVA 0.0831


Top enriched genes
Top 20 genes
GeneID Gene Rank
SORD 10697
XYLB 10642
CRYL1 8977
AKR1A1 6271
DCXR 2418

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All member genes
GeneID Gene Rank
SORD 10697
XYLB 10642
CRYL1 8977
AKR1A1 6271
DCXR 2418


Defective LFNG causes SCDO3
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0083
s.dist 0.682
p.adjustANOVA 0.0911


Top enriched genes
Top 20 genes
GeneID Gene Rank
LFNG 10842
NOTCH4 9614
NOTCH2 8818
NOTCH1 8031
NOTCH3 789

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All member genes
GeneID Gene Rank
LFNG 10842
NOTCH4 9614
NOTCH2 8818
NOTCH1 8031
NOTCH3 789


Fructose metabolism
set Fructose metabolism
setSize 7
pANOVA 0.00181
s.dist 0.681
p.adjustANOVA 0.0371


Top enriched genes
Top 20 genes
GeneID Gene Rank
SORD 10697
ALDH1A1 10206
TKFC 8841
KHK 8770
AKR1B1 8220
GLYCTK 5714
ALDOB 829

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SORD 10697
ALDH1A1 10206
TKFC 8841
KHK 8770
AKR1B1 8220
GLYCTK 5714
ALDOB 829


Formation of the ureteric bud
set Formation of the ureteric bud
setSize 5
pANOVA 0.0109
s.dist -0.658
p.adjustANOVA 0.107


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXC1 -10826
WNT11 -9844
GREM1 -8770
RET -8715
ITGB1 2616

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXC1 -10826
WNT11 -9844
GREM1 -8770
RET -8715
ITGB1 2616


NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
set NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
setSize 8
pANOVA 0.0013
s.dist 0.656
p.adjustANOVA 0.0293


Top enriched genes
Top 20 genes
GeneID Gene Rank
NR1H3 10213
SREBF1 10118
SCD 10026
RXRA 8824
FASN 6410
RXRB 6062
NRIP1 5370
NR1H2 1695

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NR1H3 10213
SREBF1 10118
SCD 10026
RXRA 8824
FASN 6410
RXRB 6062
NRIP1 5370
NR1H2 1695


LTC4-CYSLTR mediated IL4 production
set LTC4-CYSLTR mediated IL4 production
setSize 5
pANOVA 0.0123
s.dist 0.647
p.adjustANOVA 0.116


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYSLTR2 11083
GGT5 10418
CYSLTR1 7249
DPEP2 4293
GGT1 3128

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All member genes
GeneID Gene Rank
CYSLTR2 11083
GGT5 10418
CYSLTR1 7249
DPEP2 4293
GGT1 3128


Fructose catabolism
set Fructose catabolism
setSize 5
pANOVA 0.0175
s.dist 0.614
p.adjustANOVA 0.146


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALDH1A1 10206
TKFC 8841
KHK 8770
GLYCTK 5714
ALDOB 829

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALDH1A1 10206
TKFC 8841
KHK 8770
GLYCTK 5714
ALDOB 829


Erythrocytes take up oxygen and release carbon dioxide
set Erythrocytes take up oxygen and release carbon dioxide
setSize 7
pANOVA 0.00583
s.dist -0.602
p.adjustANOVA 0.0762


Top enriched genes
Top 20 genes
GeneID Gene Rank
AQP1 -8584
CA4 -8075
SLC4A1 -7566
CA1 -6896
CA2 -5818
HBB -4948
HBA1 -3565

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AQP1 -8584
CA4 -8075
SLC4A1 -7566
CA1 -6896
CA2 -5818
HBB -4948
HBA1 -3565


MECP2 regulates transcription of neuronal ligands
set MECP2 regulates transcription of neuronal ligands
setSize 5
pANOVA 0.02
s.dist 0.601
p.adjustANOVA 0.156


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLL1 8940
HDAC1 7597
MECP2 6985
SIN3A 5123
CREB1 5012

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLL1 8940
HDAC1 7597
MECP2 6985
SIN3A 5123
CREB1 5012


Defects in biotin (Btn) metabolism
set Defects in biotin (Btn) metabolism
setSize 8
pANOVA 0.00416
s.dist 0.585
p.adjustANOVA 0.0631


Top enriched genes
Top 20 genes
GeneID Gene Rank
BTD 10011
ACACA 9984
MCCC1 9886
PC 9317
PCCA 8793
MCCC2 7446
PCCB 2671
HLCS -5655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BTD 10011
ACACA 9984
MCCC1 9886
PC 9317
PCCA 8793
MCCC2 7446
PCCB 2671
HLCS -5655


Alternative complement activation
set Alternative complement activation
setSize 5
pANOVA 0.0238
s.dist 0.584
p.adjustANOVA 0.171


Top enriched genes
Top 20 genes
GeneID Gene Rank
C3 9747
GZMM 7315
CFB 6722
CFD 4672
CFP 4247

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 9747
GZMM 7315
CFB 6722
CFD 4672
CFP 4247


APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
set APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
setSize 7
pANOVA 0.00975
s.dist 0.564
p.adjustANOVA 0.0997


Top enriched genes
Top 20 genes
GeneID Gene Rank
LIG3 10360
OGG1 9137
PNKP 9100
XRCC1 7150
POLB 6083
NEIL2 4955
NEIL1 -2508

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LIG3 10360
OGG1 9137
PNKP 9100
XRCC1 7150
POLB 6083
NEIL2 4955
NEIL1 -2508


Phenylalanine metabolism
set Phenylalanine metabolism
setSize 5
pANOVA 0.0307
s.dist 0.558
p.adjustANOVA 0.198


Top enriched genes
Top 20 genes
GeneID Gene Rank
ASRGL1 11087
KYAT1 9958
QDPR 8673
IL4I1 6471
PCBD1 -4892

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ASRGL1 11087
KYAT1 9958
QDPR 8673
IL4I1 6471
PCBD1 -4892


MET activates RAP1 and RAC1
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.0025
s.dist -0.552
p.adjustANOVA 0.0459


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF -10351
RAP1A -9999
GAB1 -9178
RAP1B -7726
RAC1 -7398
CRK -6130
GRB2 -4637
DOCK7 -3436
CRKL -1549
RAPGEF1 926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HGF -10351
RAP1A -9999
GAB1 -9178
RAP1B -7726
RAC1 -7398
CRK -6130
GRB2 -4637
DOCK7 -3436
CRKL -1549
RAPGEF1 926


ATF6 (ATF6-alpha) activates chaperone genes
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.00265
s.dist -0.549
p.adjustANOVA 0.0478


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 -10603
ATF4 -9533
CALR -9524
HSP90B1 -8841
XBP1 -7887
NFYC -7669
ATF6 -7373
NFYA -3512
DDIT3 -3411
NFYB 9239

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 -10603
ATF4 -9533
CALR -9524
HSP90B1 -8841
XBP1 -7887
NFYC -7669
ATF6 -7373
NFYA -3512
DDIT3 -3411
NFYB 9239


MET activates PI3K/AKT signaling
set MET activates PI3K/AKT signaling
setSize 5
pANOVA 0.0362
s.dist -0.541
p.adjustANOVA 0.216


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF -10351
GAB1 -9178
PIK3R1 -5491
GRB2 -4637
PIK3CA 524

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HGF -10351
GAB1 -9178
PIK3R1 -5491
GRB2 -4637
PIK3CA 524


Defective HLCS causes multiple carboxylase deficiency
set Defective HLCS causes multiple carboxylase deficiency
setSize 7
pANOVA 0.0133
s.dist 0.54
p.adjustANOVA 0.121


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACACA 9984
MCCC1 9886
PC 9317
PCCA 8793
MCCC2 7446
PCCB 2671
HLCS -5655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACACA 9984
MCCC1 9886
PC 9317
PCCA 8793
MCCC2 7446
PCCB 2671
HLCS -5655


Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
set Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
setSize 6
pANOVA 0.0257
s.dist -0.526
p.adjustANOVA 0.179


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP1B1 -9684
CYP2C8 -7573
CYP1A2 -5548
CYP2U1 -4674
CYP4F2 -3570
CYP2C9 -2910

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP1B1 -9684
CYP2C8 -7573
CYP1A2 -5548
CYP2U1 -4674
CYP4F2 -3570
CYP2C9 -2910


Reversible hydration of carbon dioxide
set Reversible hydration of carbon dioxide
setSize 8
pANOVA 0.01
s.dist -0.526
p.adjustANOVA 0.101


Top enriched genes
Top 20 genes
GeneID Gene Rank
CA5B -9386
CA4 -8075
CA14 -7278
CA13 -7233
CA1 -6896
CA2 -5818
CA6 -2236
CA3 1651

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CA5B -9386
CA4 -8075
CA14 -7278
CA13 -7233
CA1 -6896
CA2 -5818
CA6 -2236
CA3 1651


Propionyl-CoA catabolism
set Propionyl-CoA catabolism
setSize 5
pANOVA 0.0444
s.dist 0.519
p.adjustANOVA 0.242


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCEE 10643
PCCA 8793
MMAA 3972
MMUT 3079
PCCB 2671

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCEE 10643
PCCA 8793
MMAA 3972
MMUT 3079
PCCB 2671


Synthesis of PG
set Synthesis of PG
setSize 8
pANOVA 0.0116
s.dist 0.515
p.adjustANOVA 0.111


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLD4 11119
PLD3 10180
PLD2 8291
PLD6 7285
DUSP23 6552
PLD1 2859
CDS2 1774
PGS1 -1763

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLD4 11119
PLD3 10180
PLD2 8291
PLD6 7285
DUSP23 6552
PLD1 2859
CDS2 1774
PGS1 -1763


Negative regulation of TCF-dependent signaling by DVL-interacting proteins
set Negative regulation of TCF-dependent signaling by DVL-interacting proteins
setSize 5
pANOVA 0.0465
s.dist 0.514
p.adjustANOVA 0.25


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL2 10521
DVL3 5759
CCDC88C 5648
DVL1 4414
CXXC4 2536

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DVL2 10521
DVL3 5759
CCDC88C 5648
DVL1 4414
CXXC4 2536


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0466
s.dist 0.514
p.adjustANOVA 0.25


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 9442
SUOX 9410
ETHE1 8036
TST 3522
TSTD1 -1544

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 9442
SUOX 9410
ETHE1 8036
TST 3522
TSTD1 -1544


Defective binding of VWF variant to GPIb:IX:V
set Defective binding of VWF variant to GPIb:IX:V
setSize 7
pANOVA 0.019
s.dist -0.512
p.adjustANOVA 0.154


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL1A1 -9600
GP9 -7555
GP5 -6424
COL1A2 -5787
GP1BA -5145
VWF -3582
GP1BB -452

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 -9600
GP9 -7555
GP5 -6424
COL1A2 -5787
GP1BA -5145
VWF -3582
GP1BB -452


Enhanced binding of GP1BA variant to VWF multimer:collagen
set Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize 7
pANOVA 0.019
s.dist -0.512
p.adjustANOVA 0.154


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL1A1 -9600
GP9 -7555
GP5 -6424
COL1A2 -5787
GP1BA -5145
VWF -3582
GP1BB -452

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 -9600
GP9 -7555
GP5 -6424
COL1A2 -5787
GP1BA -5145
VWF -3582
GP1BB -452


PTK6 Regulates Cell Cycle
set PTK6 Regulates Cell Cycle
setSize 6
pANOVA 0.0344
s.dist 0.499
p.adjustANOVA 0.21


Top enriched genes
Top 20 genes
GeneID Gene Rank
CDK4 10114
CCNE1 9613
CDKN1B 8157
CCND1 4771
PTK6 2257
CDK2 -1276

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDK4 10114
CCNE1 9613
CDKN1B 8157
CCND1 4771
PTK6 2257
CDK2 -1276


Activation of NOXA and translocation to mitochondria
set Activation of NOXA and translocation to mitochondria
setSize 5
pANOVA 0.0567
s.dist 0.492
p.adjustANOVA 0.274


Top enriched genes
Top 20 genes
GeneID Gene Rank
TP53 10789
TFDP2 9170
E2F1 8528
PMAIP1 6119
TFDP1 -6931

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TP53 10789
TFDP2 9170
E2F1 8528
PMAIP1 6119
TFDP1 -6931


Molybdenum cofactor biosynthesis
set Molybdenum cofactor biosynthesis
setSize 6
pANOVA 0.0385
s.dist 0.488
p.adjustANOVA 0.225


Top enriched genes
Top 20 genes
GeneID Gene Rank
MOCS3 9490
NFS1 8416
GPHN 6757
MOCS1 4522
MOCOS 2452
MOCS2 1295

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MOCS3 9490
NFS1 8416
GPHN 6757
MOCS1 4522
MOCOS 2452
MOCS2 1295


IFNG signaling activates MAPKs
set IFNG signaling activates MAPKs
setSize 8
pANOVA 0.0174
s.dist -0.486
p.adjustANOVA 0.146


Top enriched genes
Top 20 genes
GeneID Gene Rank
IFNGR1 -10725
MAPK1 -10284
IFNGR2 -9877
JAK1 -5390
IFNG -4515
JAK2 -3619
MAPK3 -643
RAF1 3316

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNGR1 -10725
MAPK1 -10284
IFNGR2 -9877
JAK1 -5390
IFNG -4515
JAK2 -3619
MAPK3 -643
RAF1 3316


Carnitine shuttle
set Carnitine shuttle
setSize 12
pANOVA 0.00365
s.dist 0.485
p.adjustANOVA 0.0598


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACACA 9984
SLC22A5 9086
RXRA 8824
SLC25A20 8810
CPT2 7961
MID1IP1 7658
PPARD 6929
ACACB 4558
PRKAG2 1935
CPT1A 1916
PRKAB2 -771
CPT1B -1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACACA 9984
SLC22A5 9086
RXRA 8824
SLC25A20 8810
CPT2 7961
MID1IP1 7658
PPARD 6929
ACACB 4558
PRKAG2 1935
CPT1A 1916
PRKAB2 -771
CPT1B -1486


Unwinding of DNA
set Unwinding of DNA
setSize 12
pANOVA 0.00373
s.dist 0.483
p.adjustANOVA 0.06


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCM4 10334
GINS3 9858
GINS2 9434
CDC45 8582
MCM7 8379
MCM3 7887
MCM5 7237
MCM6 4384
MCM2 2977
GINS4 885
GINS1 544
MCM8 -5244

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM4 10334
GINS3 9858
GINS2 9434
CDC45 8582
MCM7 8379
MCM3 7887
MCM5 7237
MCM6 4384
MCM2 2977
GINS4 885
GINS1 544
MCM8 -5244


Type I hemidesmosome assembly
set Type I hemidesmosome assembly
setSize 8
pANOVA 0.0185
s.dist 0.481
p.adjustANOVA 0.152


Top enriched genes
Top 20 genes
GeneID Gene Rank
DST 11086
KRT5 10889
ITGB4 9662
CD151 9488
LAMB3 8108
COL17A1 5298
PLEC -5466
ITGA6 -5785

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DST 11086
KRT5 10889
ITGB4 9662
CD151 9488
LAMB3 8108
COL17A1 5298
PLEC -5466
ITGA6 -5785


Signal attenuation
set Signal attenuation
setSize 9
pANOVA 0.0125
s.dist -0.481
p.adjustANOVA 0.117


Top enriched genes
Top 20 genes
GeneID Gene Rank
GRB10 -10862
INSR -10833
MAPK1 -10284
IRS2 -10086
GRB2 -4637
MAPK3 -643
IRS1 -555
SOS1 -53
SHC1 1491

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB10 -10862
INSR -10833
MAPK1 -10284
IRS2 -10086
GRB2 -4637
MAPK3 -643
IRS1 -555
SOS1 -53
SHC1 1491


Creation of C4 and C2 activators
set Creation of C4 and C2 activators
setSize 71
pANOVA 2.71e-12
s.dist 0.48
p.adjustANOVA 2.62e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV3D-20 10773
IGLV1-36 10755
FCN1 10716
IGLV3-21 10676
IGLV3-25 10570
IGHG1 10558
IGLV5-45 10532
IGLV6-57 10524
IGLC2 10314
IGLV1-47 10220
IGLV1-51 10182
IGLC1 10148
IGLV3-1 10099
IGKV2-28 10095
IGLV2-8 9978
IGLV2-14 9972
IGKV1D-39 9907
IGLV7-46 9815
IGHG4 9510
IGHV4-39 9357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3D-20 10773
IGLV1-36 10755
FCN1 10716
IGLV3-21 10676
IGLV3-25 10570
IGHG1 10558
IGLV5-45 10532
IGLV6-57 10524
IGLC2 10314
IGLV1-47 10220
IGLV1-51 10182
IGLC1 10148
IGLV3-1 10099
IGKV2-28 10095
IGLV2-8 9978
IGLV2-14 9972
IGKV1D-39 9907
IGLV7-46 9815
IGHG4 9510
IGHV4-39 9357
IGKV3-20 8992
IGLV2-11 8960
IGLV1-40 8874
IGKV3-15 8763
IGHV1-2 8751
IGHV2-70 8681
IGLV7-43 8667
IGHV4-34 8652
IGLV3-27 8501
C1QC 8338
IGLC3 7936
IGLV8-61 7918
IGHV4-59 7536
MASP2 7402
IGLV2-23 7334
IGHV3-33 7208
IGKC 6953
IGHV3-30 6900
C1S 6302
IGKV4-1 6112
IGKV1-5 6086
C1QA 5810
IGKV1-33 5589
IGLV3-12 5387
IGHV1-46 5331
IGHG3 5230
IGHV3-7 5044
IGKV1-12 4890
IGLV3-19 4651
IGHV3-11 4379
IGHG2 3707
IGLC7 3486
IGHV3-13 3314
IGLV1-44 3136
IGHV1-69 2336
IGHV2-5 1010
IGKV2-29 639
IGKV1-17 405
IGKV2D-28 0
IGHV3-23 -100
IGKV2-30 -211
C1R -1856
IGLV4-60 -2001
IGKV1-16 -2267
IGHV3-53 -4427
C1QB -4713
IGHV3-48 -5007
IGLV10-54 -6919
IGKV3-11 -7201
IGLV4-69 -7562
IGLV2-18 -9559


Initial triggering of complement
set Initial triggering of complement
setSize 79
pANOVA 2.97e-13
s.dist 0.475
p.adjustANOVA 5.73e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV3D-20 10773
IGLV1-36 10755
FCN1 10716
IGLV3-21 10676
IGLV3-25 10570
IGHG1 10558
IGLV5-45 10532
IGLV6-57 10524
IGLC2 10314
IGLV1-47 10220
IGLV1-51 10182
IGLC1 10148
IGLV3-1 10099
IGKV2-28 10095
IGLV2-8 9978
IGLV2-14 9972
IGKV1D-39 9907
IGLV7-46 9815
C3 9747
IGHG4 9510

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3D-20 10773
IGLV1-36 10755
FCN1 10716
IGLV3-21 10676
IGLV3-25 10570
IGHG1 10558
IGLV5-45 10532
IGLV6-57 10524
IGLC2 10314
IGLV1-47 10220
IGLV1-51 10182
IGLC1 10148
IGLV3-1 10099
IGKV2-28 10095
IGLV2-8 9978
IGLV2-14 9972
IGKV1D-39 9907
IGLV7-46 9815
C3 9747
IGHG4 9510
IGHV4-39 9357
IGKV3-20 8992
IGLV2-11 8960
IGLV1-40 8874
IGKV3-15 8763
IGHV1-2 8751
IGHV2-70 8681
IGLV7-43 8667
IGHV4-34 8652
IGLV3-27 8501
C1QC 8338
IGLC3 7936
IGLV8-61 7918
IGHV4-59 7536
MASP2 7402
IGLV2-23 7334
GZMM 7315
IGHV3-33 7208
IGKC 6953
IGHV3-30 6900
CFB 6722
C4A 6390
C1S 6302
IGKV4-1 6112
IGKV1-5 6086
C1QA 5810
IGKV1-33 5589
IGLV3-12 5387
IGHV1-46 5331
IGHG3 5230
IGHV3-7 5044
IGKV1-12 4890
CFD 4672
IGLV3-19 4651
IGHV3-11 4379
CFP 4247
IGHG2 3707
IGLC7 3486
C2 3382
IGHV3-13 3314
IGLV1-44 3136
IGHV1-69 2336
IGHV2-5 1010
IGKV2-29 639
IGKV1-17 405
IGKV2D-28 0
IGHV3-23 -100
IGKV2-30 -211
C1R -1856
IGLV4-60 -2001
IGKV1-16 -2267
C4B -3997
IGHV3-53 -4427
C1QB -4713
IGHV3-48 -5007
IGLV10-54 -6919
IGKV3-11 -7201
IGLV4-69 -7562
IGLV2-18 -9559


Translocation of ZAP-70 to Immunological synapse
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 6.15e-05
s.dist 0.472
p.adjustANOVA 0.00475


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD4 11041
HLA-DPA1 10948
TRAV29DV5 10863
HLA-DRA 10849
TRAV19 10512
TRBV7-9 10332
HLA-DPB1 10226
TRAC 10062
HLA-DRB1 9416
HLA-DQA2 9026
HLA-DQB2 7621
TRAV8-4 7344
HLA-DQA1 6248
LCK 6181
HLA-DRB5 6102
ZAP70 5908
TRBC1 3352
TRBV12-3 2796
CD247 2550
PTPN22 -1116

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD4 11041
HLA-DPA1 10948
TRAV29DV5 10863
HLA-DRA 10849
TRAV19 10512
TRBV7-9 10332
HLA-DPB1 10226
TRAC 10062
HLA-DRB1 9416
HLA-DQA2 9026
HLA-DQB2 7621
TRAV8-4 7344
HLA-DQA1 6248
LCK 6181
HLA-DRB5 6102
ZAP70 5908
TRBC1 3352
TRBV12-3 2796
CD247 2550
PTPN22 -1116
HLA-DQB1 -3452
CD3E -4239
CD3D -5604
CD3G -9434


Classical antibody-mediated complement activation
set Classical antibody-mediated complement activation
setSize 69
pANOVA 1.45e-11
s.dist 0.47
p.adjustANOVA 9.36e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV3D-20 10773
IGLV1-36 10755
IGLV3-21 10676
IGLV3-25 10570
IGHG1 10558
IGLV5-45 10532
IGLV6-57 10524
IGLC2 10314
IGLV1-47 10220
IGLV1-51 10182
IGLC1 10148
IGLV3-1 10099
IGKV2-28 10095
IGLV2-8 9978
IGLV2-14 9972
IGKV1D-39 9907
IGLV7-46 9815
IGHG4 9510
IGHV4-39 9357
IGKV3-20 8992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3D-20 10773
IGLV1-36 10755
IGLV3-21 10676
IGLV3-25 10570
IGHG1 10558
IGLV5-45 10532
IGLV6-57 10524
IGLC2 10314
IGLV1-47 10220
IGLV1-51 10182
IGLC1 10148
IGLV3-1 10099
IGKV2-28 10095
IGLV2-8 9978
IGLV2-14 9972
IGKV1D-39 9907
IGLV7-46 9815
IGHG4 9510
IGHV4-39 9357
IGKV3-20 8992
IGLV2-11 8960
IGLV1-40 8874
IGKV3-15 8763
IGHV1-2 8751
IGHV2-70 8681
IGLV7-43 8667
IGHV4-34 8652
IGLV3-27 8501
C1QC 8338
IGLC3 7936
IGLV8-61 7918
IGHV4-59 7536
IGLV2-23 7334
IGHV3-33 7208
IGKC 6953
IGHV3-30 6900
C1S 6302
IGKV4-1 6112
IGKV1-5 6086
C1QA 5810
IGKV1-33 5589
IGLV3-12 5387
IGHV1-46 5331
IGHG3 5230
IGHV3-7 5044
IGKV1-12 4890
IGLV3-19 4651
IGHV3-11 4379
IGHG2 3707
IGLC7 3486
IGHV3-13 3314
IGLV1-44 3136
IGHV1-69 2336
IGHV2-5 1010
IGKV2-29 639
IGKV1-17 405
IGKV2D-28 0
IGHV3-23 -100
IGKV2-30 -211
C1R -1856
IGLV4-60 -2001
IGKV1-16 -2267
IGHV3-53 -4427
C1QB -4713
IGHV3-48 -5007
IGLV10-54 -6919
IGKV3-11 -7201
IGLV4-69 -7562
IGLV2-18 -9559


Estrogen-stimulated signaling through PRKCZ
set Estrogen-stimulated signaling through PRKCZ
setSize 6
pANOVA 0.0467
s.dist -0.469
p.adjustANOVA 0.25


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 -10284
PDPK1 -8967
NRAS -6803
KRAS -4474
PRKCZ -3212
HRAS 3540

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -10284
PDPK1 -8967
NRAS -6803
KRAS -4474
PRKCZ -3212
HRAS 3540


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.0237
s.dist 0.462
p.adjustANOVA 0.171


Top enriched genes
Top 20 genes
GeneID Gene Rank
PARG 9769
FEN1 8028
PARP2 7555
POLB 6083
LIG1 4939
APEX1 4029
ADPRS 2759
PARP1 -1552

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARG 9769
FEN1 8028
PARP2 7555
POLB 6083
LIG1 4939
APEX1 4029
ADPRS 2759
PARP1 -1552


Diseases of Base Excision Repair
set Diseases of Base Excision Repair
setSize 5
pANOVA 0.0749
s.dist 0.46
p.adjustANOVA 0.321


Top enriched genes
Top 20 genes
GeneID Gene Rank
OGG1 9137
MUTYH 8664
NTHL1 5830
NEIL3 4781
NEIL1 -2508

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OGG1 9137
MUTYH 8664
NTHL1 5830
NEIL3 4781
NEIL1 -2508


YAP1- and WWTR1 (TAZ)-stimulated gene expression
set YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize 7
pANOVA 0.0352
s.dist -0.46
p.adjustANOVA 0.213


Top enriched genes
Top 20 genes
GeneID Gene Rank
HIPK2 -9893
WWTR1 -9359
TEAD2 -7616
KAT2B -5327
HIPK1 -2246
RUNX2 -1906
NPPA 1828

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIPK2 -9893
WWTR1 -9359
TEAD2 -7616
KAT2B -5327
HIPK1 -2246
RUNX2 -1906
NPPA 1828


Biotin transport and metabolism
set Biotin transport and metabolism
setSize 11
pANOVA 0.00842
s.dist 0.459
p.adjustANOVA 0.092


Top enriched genes
Top 20 genes
GeneID Gene Rank
BTD 10011
ACACA 9984
MCCC1 9886
PC 9317
PCCA 8793
MCCC2 7446
ACACB 4558
PCCB 2671
PDZD11 2019
SLC5A6 -2202
HLCS -5655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BTD 10011
ACACA 9984
MCCC1 9886
PC 9317
PCCA 8793
MCCC2 7446
ACACB 4558
PCCB 2671
PDZD11 2019
SLC5A6 -2202
HLCS -5655


Formation of the active cofactor, UDP-glucuronate
set Formation of the active cofactor, UDP-glucuronate
setSize 5
pANOVA 0.0778
s.dist -0.455
p.adjustANOVA 0.327


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC35D2 -9915
UGP2 -9577
UGDH -8690
SLC35D1 -1652
UXS1 5405

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC35D2 -9915
UGP2 -9577
UGDH -8690
SLC35D1 -1652
UXS1 5405


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.0375
s.dist -0.454
p.adjustANOVA 0.221


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLR2 -10700
UBC -9891
B2M -5296
UBB -3507
MRC1 -2766
RPS27A -2575
UBA52 644

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 -10700
UBC -9891
B2M -5296
UBB -3507
MRC1 -2766
RPS27A -2575
UBA52 644


Erythrocytes take up carbon dioxide and release oxygen
set Erythrocytes take up carbon dioxide and release oxygen
setSize 11
pANOVA 0.00929
s.dist -0.453
p.adjustANOVA 0.0971


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYB5R2 -10636
AQP1 -8584
CYB5R4 -8094
CA4 -8075
SLC4A1 -7566
CA1 -6896
CA2 -5818
HBB -4948
HBA1 -3565
CYB5R1 771
CYB5RL 9994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYB5R2 -10636
AQP1 -8584
CYB5R4 -8094
CA4 -8075
SLC4A1 -7566
CA1 -6896
CA2 -5818
HBB -4948
HBA1 -3565
CYB5R1 771
CYB5RL 9994


O2/CO2 exchange in erythrocytes
set O2/CO2 exchange in erythrocytes
setSize 11
pANOVA 0.00929
s.dist -0.453
p.adjustANOVA 0.0971


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYB5R2 -10636
AQP1 -8584
CYB5R4 -8094
CA4 -8075
SLC4A1 -7566
CA1 -6896
CA2 -5818
HBB -4948
HBA1 -3565
CYB5R1 771
CYB5RL 9994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYB5R2 -10636
AQP1 -8584
CYB5R4 -8094
CA4 -8075
SLC4A1 -7566
CA1 -6896
CA2 -5818
HBB -4948
HBA1 -3565
CYB5R1 771
CYB5RL 9994


Phosphorylation of Emi1
set Phosphorylation of Emi1
setSize 6
pANOVA 0.0547
s.dist 0.453
p.adjustANOVA 0.267


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLK1 10107
CDC20 7927
CDK1 7506
FZR1 6256
FBXO5 1104
CCNB1 -2284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLK1 10107
CDC20 7927
CDK1 7506
FZR1 6256
FBXO5 1104
CCNB1 -2284


Organic anion transporters
set Organic anion transporters
setSize 7
pANOVA 0.0388
s.dist 0.451
p.adjustANOVA 0.225


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 9442
SLC25A11 8644
SLC5A5 7659
SLC25A22 7190
SLC25A1 6617
SLC17A5 3018
SLC17A7 -6997

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 9442
SLC25A11 8644
SLC5A5 7659
SLC25A22 7190
SLC25A1 6617
SLC17A5 3018
SLC17A7 -6997


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report