Mitch Report

date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-0.8269284
A1BG	1.0230718
A1BG-AS1	-0.3566462
A1CF	-2.0130109
A2M	-3.0357344
A2M-AS1	-2.5241224

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2725
num_genes_in_profile	21870
duplicated_genes_present	0
num_profile_genes_in_sets	8802
num_profile_genes_not_in_sets	13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1189
num_genesets_included	1536

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Phosphorylation of Emi1	6	1.03e-03	0.774	4.81e-03
Classical antibody-mediated complement activation	70	2.65e-28	0.762	3.93e-26
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	3.82e-03	0.747	1.47e-02
Scavenging of heme from plasma	71	4.36e-27	0.739	5.25e-25
Creation of C4 and C2 activators	72	3.27e-27	0.735	4.20e-25
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	4.60e-04	0.715	2.44e-03
Maturation of spike protein 9683686	5	5.77e-03	0.713	2.04e-02
Initial triggering of complement	80	8.70e-27	0.692	9.68e-25
FCGR activation	77	1.59e-25	0.687	1.61e-23
Synthesis of GDP-mannose	6	3.81e-03	0.682	1.47e-02
CD22 mediated BCR regulation	59	1.89e-19	0.678	8.66e-18
Glycosphingolipid transport	7	2.09e-03	0.672	8.91e-03
Formation of annular gap junctions	10	2.51e-04	0.669	1.44e-03
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	9.93e-03	0.666	3.20e-02
Role of LAT2/NTAL/LAB on calcium mobilization	78	5.74e-23	0.646	3.69e-21
Sulfide oxidation to sulfate	5	1.26e-02	0.645	3.86e-02
Type I hemidesmosome assembly	8	1.60e-03	0.644	7.14e-03
Diseases of Base Excision Repair	5	1.29e-02	0.642	3.92e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	3.44e-03	0.638	1.35e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.37e-02	0.636	4.11e-02
Unwinding of DNA	12	1.96e-04	0.621	1.17e-03
Glyoxylate metabolism and glycine degradation	13	1.07e-04	0.620	7.14e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	4.50e-03	0.620	1.69e-02
G2/M DNA replication checkpoint	5	1.70e-02	0.616	4.90e-02
Role of phospholipids in phagocytosis	89	2.15e-23	0.610	1.48e-21
Binding and Uptake of Ligands by Scavenger Receptors	93	1.60e-23	0.599	1.14e-21
Regulation of NFE2L2 gene expression	8	3.68e-03	0.593	1.43e-02
Nef Mediated CD4 Down-regulation	9	2.16e-03	0.590	9.20e-03
Expression and translocation of olfactory receptors	52	2.39e-13	-0.587	7.54e-12
FCGR3A-mediated IL10 synthesis	100	5.73e-24	0.584	4.25e-22
Retrograde neurotrophin signalling	12	4.79e-04	0.582	2.52e-03
Formation of ATP by chemiosmotic coupling	20	7.81e-06	0.577	7.77e-05
FCERI mediated Ca+2 mobilization	93	1.21e-21	0.573	5.96e-20
Synthesis of PG	8	5.18e-03	0.571	1.86e-02
Regulation of Complement cascade	97	4.35e-22	0.567	2.62e-20
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.15e-05	0.567	2.65e-04
Nef Mediated CD8 Down-regulation	7	9.53e-03	0.566	3.09e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	3.40e-03	0.564	1.34e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	2.94e-02	0.562	7.53e-02
VLDLR internalisation and degradation	15	1.71e-04	0.560	1.05e-03
Pausing and recovery of Tat-mediated HIV elongation	30	1.37e-07	0.556	1.90e-06
Tat-mediated HIV elongation arrest and recovery	30	1.37e-07	0.556	1.90e-06
Complement cascade	101	5.16e-22	0.555	3.01e-20
FCGR3A-mediated phagocytosis	122	2.77e-25	0.544	2.43e-23
Leishmania phagocytosis	122	2.77e-25	0.544	2.43e-23
Parasite infection	122	2.77e-25	0.544	2.43e-23
Abortive elongation of HIV-1 transcript in the absence of Tat	23	6.98e-06	0.541	7.08e-05
Gap junction degradation	11	1.98e-03	0.539	8.52e-03
Activation of PUMA and translocation to mitochondria	9	5.25e-03	0.537	1.88e-02
Prevention of phagosomal-lysosomal fusion	9	5.31e-03	0.537	1.90e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Phosphorylation of Emi1	6	1.03e-03	0.774000	4.81e-03
Classical antibody-mediated complement activation	70	2.65e-28	0.762000	3.93e-26
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	3.82e-03	0.747000	1.47e-02
Scavenging of heme from plasma	71	4.36e-27	0.739000	5.25e-25
Creation of C4 and C2 activators	72	3.27e-27	0.735000	4.20e-25
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	4.60e-04	0.715000	2.44e-03
Maturation of spike protein 9683686	5	5.77e-03	0.713000	2.04e-02
Initial triggering of complement	80	8.70e-27	0.692000	9.68e-25
FCGR activation	77	1.59e-25	0.687000	1.61e-23
Synthesis of GDP-mannose	6	3.81e-03	0.682000	1.47e-02
CD22 mediated BCR regulation	59	1.89e-19	0.678000	8.66e-18
Glycosphingolipid transport	7	2.09e-03	0.672000	8.91e-03
Formation of annular gap junctions	10	2.51e-04	0.669000	1.44e-03
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	9.93e-03	0.666000	3.20e-02
Role of LAT2/NTAL/LAB on calcium mobilization	78	5.74e-23	0.646000	3.69e-21
Sulfide oxidation to sulfate	5	1.26e-02	0.645000	3.86e-02
Type I hemidesmosome assembly	8	1.60e-03	0.644000	7.14e-03
Diseases of Base Excision Repair	5	1.29e-02	0.642000	3.92e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	3.44e-03	0.638000	1.35e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.37e-02	0.636000	4.11e-02
Unwinding of DNA	12	1.96e-04	0.621000	1.17e-03
Glyoxylate metabolism and glycine degradation	13	1.07e-04	0.620000	7.14e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	4.50e-03	0.620000	1.69e-02
G2/M DNA replication checkpoint	5	1.70e-02	0.616000	4.90e-02
Role of phospholipids in phagocytosis	89	2.15e-23	0.610000	1.48e-21
Binding and Uptake of Ligands by Scavenger Receptors	93	1.60e-23	0.599000	1.14e-21
Regulation of NFE2L2 gene expression	8	3.68e-03	0.593000	1.43e-02
Nef Mediated CD4 Down-regulation	9	2.16e-03	0.590000	9.20e-03
Expression and translocation of olfactory receptors	52	2.39e-13	-0.587000	7.54e-12
FCGR3A-mediated IL10 synthesis	100	5.73e-24	0.584000	4.25e-22
Retrograde neurotrophin signalling	12	4.79e-04	0.582000	2.52e-03
Formation of ATP by chemiosmotic coupling	20	7.81e-06	0.577000	7.77e-05
FCERI mediated Ca+2 mobilization	93	1.21e-21	0.573000	5.96e-20
Synthesis of PG	8	5.18e-03	0.571000	1.86e-02
Regulation of Complement cascade	97	4.35e-22	0.567000	2.62e-20
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.15e-05	0.567000	2.65e-04
Nef Mediated CD8 Down-regulation	7	9.53e-03	0.566000	3.09e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	3.40e-03	0.564000	1.34e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	2.94e-02	0.562000	7.53e-02
VLDLR internalisation and degradation	15	1.71e-04	0.560000	1.05e-03
Pausing and recovery of Tat-mediated HIV elongation	30	1.37e-07	0.556000	1.90e-06
Tat-mediated HIV elongation arrest and recovery	30	1.37e-07	0.556000	1.90e-06
Complement cascade	101	5.16e-22	0.555000	3.01e-20
FCGR3A-mediated phagocytosis	122	2.77e-25	0.544000	2.43e-23
Leishmania phagocytosis	122	2.77e-25	0.544000	2.43e-23
Parasite infection	122	2.77e-25	0.544000	2.43e-23
Abortive elongation of HIV-1 transcript in the absence of Tat	23	6.98e-06	0.541000	7.08e-05
Gap junction degradation	11	1.98e-03	0.539000	8.52e-03
Activation of PUMA and translocation to mitochondria	9	5.25e-03	0.537000	1.88e-02
Prevention of phagosomal-lysosomal fusion	9	5.31e-03	0.537000	1.90e-02
Glycine degradation	7	1.41e-02	0.536000	4.20e-02
FCERI mediated MAPK activation	94	3.55e-19	0.534000	1.55e-17
Condensation of Prometaphase Chromosomes	11	2.19e-03	0.533000	9.30e-03
Regulation of actin dynamics for phagocytic cup formation	124	1.36e-24	0.532000	1.09e-22
XBP1(S) activates chaperone genes	44	1.43e-09	0.527000	2.81e-08
ChREBP activates metabolic gene expression	7	1.68e-02	0.522000	4.87e-02
TGFBR3 regulates TGF-beta signaling	8	1.08e-02	0.521000	3.41e-02
IRE1alpha activates chaperones	46	9.91e-10	0.521000	1.99e-08
Nucleotide biosynthesis	12	1.89e-03	0.518000	8.18e-03
Olfactory Signaling Pathway	57	1.51e-11	-0.516000	3.87e-10
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	1.80e-02	0.516000	5.09e-02
HIV elongation arrest and recovery	32	4.71e-07	0.514000	5.94e-06
Pausing and recovery of HIV elongation	32	4.71e-07	0.514000	5.94e-06
Biotin transport and metabolism	11	3.23e-03	0.513000	1.30e-02
Activation of NOXA and translocation to mitochondria	5	4.98e-02	0.507000	1.14e-01
Gluconeogenesis	19	1.44e-04	0.504000	8.95e-04
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	84	2.23e-15	0.500000	8.09e-14
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	3.56e-02	0.495000	8.84e-02
WNT5A-dependent internalization of FZD4	13	2.03e-03	0.494000	8.72e-03
Polo-like kinase mediated events	16	6.72e-04	0.491000	3.35e-03
Interleukin-2 signaling	11	4.83e-03	0.491000	1.76e-02
Removal of the Flap Intermediate from the C-strand	17	4.73e-04	0.490000	2.49e-03
Assembly Of The HIV Virion	15	1.03e-03	0.490000	4.81e-03
RHOBTB3 ATPase cycle	10	7.63e-03	0.487000	2.58e-02
WNT mediated activation of DVL	8	1.72e-02	0.486000	4.91e-02
Hyaluronan metabolism	15	1.13e-03	0.486000	5.19e-03
Fcgamma receptor (FCGR) dependent phagocytosis	148	2.25e-24	0.485000	1.74e-22
Hyaluronan uptake and degradation	12	3.65e-03	0.485000	1.42e-02
NFE2L2 regulates pentose phosphate pathway genes	8	1.81e-02	0.482000	5.11e-02
Anti-inflammatory response favouring Leishmania parasite infection	133	8.12e-22	0.482000	4.12e-20
Leishmania parasite growth and survival	133	8.12e-22	0.482000	4.12e-20
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	5.76e-03	0.481000	2.04e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	9.69e-05	0.480000	6.56e-04
G1/S-Specific Transcription	29	8.51e-06	0.478000	8.33e-05
FCERI mediated NF-kB activation	130	6.65e-21	0.476000	3.13e-19
CYP2E1 reactions	5	6.72e-02	0.473000	1.43e-01
Disorders of Developmental Biology	12	4.79e-03	0.470000	1.76e-02
Disorders of Nervous System Development	12	4.79e-03	0.470000	1.76e-02
Loss of function of MECP2 in Rett syndrome	12	4.79e-03	0.470000	1.76e-02
Pervasive developmental disorders	12	4.79e-03	0.470000	1.76e-02
Negative regulation of FLT3	15	1.70e-03	0.468000	7.54e-03
Pentose phosphate pathway	13	3.56e-03	0.467000	1.39e-02
DNA methylation	18	6.52e-04	0.464000	3.25e-03
Telomere Extension By Telomerase	23	1.32e-04	0.460000	8.59e-04
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.90e-03	0.460000	1.18e-02
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	51	1.46e-08	0.458000	2.39e-07
Membrane binding and targetting of GAG proteins	13	4.26e-03	0.458000	1.61e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	4.26e-03	0.458000	1.61e-02
Activated point mutants of FGFR2	7	3.67e-02	-0.456000	9.01e-02
Passive transport by Aquaporins	6	5.33e-02	-0.455000	1.19e-01
G0 and Early G1	27	4.19e-05	0.455000	3.28e-04
Processive synthesis on the C-strand of the telomere	19	6.39e-04	0.452000	3.20e-03
Scavenging by Class F Receptors	5	8.10e-02	0.451000	1.65e-01
FGFR4 ligand binding and activation	5	8.33e-02	-0.447000	1.69e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	4.12e-02	0.445000	9.86e-02
Formation of the ureteric bud	5	8.53e-02	-0.444000	1.72e-01
Cytosolic iron-sulfur cluster assembly	13	6.11e-03	0.439000	2.12e-02
Cell-extracellular matrix interactions	15	3.31e-03	0.438000	1.32e-02
Interleukin-23 signaling	7	4.52e-02	0.437000	1.06e-01
Removal of the Flap Intermediate	14	4.63e-03	0.437000	1.72e-02
Cytoprotection by HMOX1	53	3.95e-08	0.436000	6.14e-07
Malate-aspartate shuttle	8	3.28e-02	0.436000	8.26e-02
Cell surface interactions at the vascular wall	173	4.29e-23	0.436000	2.85e-21
Josephin domain DUBs	10	1.71e-02	0.435000	4.91e-02
Maturation of spike protein 9694548	36	6.87e-06	0.433000	7.01e-05
Defective HLCS causes multiple carboxylase deficiency	7	4.74e-02	0.433000	1.10e-01
Interleukin-21 signaling	9	2.47e-02	0.432000	6.59e-02
Eicosanoids	8	3.46e-02	-0.431000	8.64e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	9.50e-02	0.431000	1.87e-01
Cleavage of the damaged purine	22	5.11e-04	0.428000	2.63e-03
Depurination	22	5.11e-04	0.428000	2.63e-03
Recognition and association of DNA glycosylase with site containing an affected purine	22	5.11e-04	0.428000	2.63e-03
RMTs methylate histone arginines	35	1.24e-05	0.427000	1.16e-04
Alternative complement activation	5	9.84e-02	0.427000	1.92e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	5.06e-02	0.427000	1.15e-01
Purine ribonucleoside monophosphate biosynthesis	9	2.69e-02	0.426000	7.05e-02
p75NTR negatively regulates cell cycle via SC1	5	9.92e-02	0.426000	1.93e-01
Nef and signal transduction	8	3.70e-02	0.426000	9.07e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	9.69e-05	0.426000	6.56e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	5.93e-03	0.425000	2.06e-02
SUMOylation of DNA methylation proteins	16	3.27e-03	0.425000	1.31e-02
Suppression of apoptosis	7	5.26e-02	0.423000	1.18e-01
Other interleukin signaling	19	1.41e-03	0.423000	6.36e-03
NFE2L2 regulating MDR associated enzymes	8	3.85e-02	0.422000	9.38e-02
DNA strand elongation	32	3.55e-05	0.422000	2.92e-04
Regulation of TP53 Activity through Acetylation	29	8.58e-05	0.421000	5.97e-04
Processive synthesis on the lagging strand	15	4.77e-03	0.421000	1.76e-02
Potential therapeutics for SARS	150	6.17e-19	0.420000	2.64e-17
APOBEC3G mediated resistance to HIV-1 infection	5	1.05e-01	0.419000	2.01e-01
Inhibition of DNA recombination at telomere	33	3.29e-05	0.418000	2.75e-04
Erythrocytes take up oxygen and release carbon dioxide	7	5.66e-02	0.416000	1.24e-01
Phospholipase C-mediated cascade; FGFR3	5	1.08e-01	-0.415000	2.05e-01
Degradation of cysteine and homocysteine	12	1.32e-02	0.413000	4.02e-02
Activation of RAC1 downstream of NMDARs	7	5.85e-02	0.413000	1.28e-01
Pyrimidine salvage	10	2.41e-02	0.412000	6.44e-02
PTK6 Regulates Cell Cycle	6	8.17e-02	0.410000	1.67e-01
FOXO-mediated transcription of cell death genes	16	4.61e-03	0.409000	1.72e-02
Complex III assembly	23	6.86e-04	0.409000	3.40e-03
Adenylate cyclase activating pathway	8	4.53e-02	0.409000	1.07e-01
Plasma lipoprotein clearance	32	6.28e-05	0.409000	4.67e-04
Telomere Maintenance	78	5.31e-10	0.407000	1.15e-08
Glycogen breakdown (glycogenolysis)	13	1.15e-02	0.405000	3.57e-02
Maturation of protein 3a 9683673	9	3.59e-02	0.404000	8.86e-02
Maturation of protein 3a 9694719	9	3.59e-02	0.404000	8.86e-02
Cristae formation	33	5.97e-05	0.404000	4.50e-04
MECP2 regulates transcription of neuronal ligands	5	1.19e-01	0.403000	2.21e-01
Response of Mtb to phagocytosis	22	1.15e-03	0.400000	5.26e-03
FGFR3 ligand binding and activation	5	1.22e-01	-0.399000	2.25e-01
FGFR3c ligand binding and activation	5	1.22e-01	-0.399000	2.25e-01
Acyl chain remodelling of PI	10	2.88e-02	-0.399000	7.39e-02
Synthesis of Dolichyl-phosphate	6	9.23e-02	0.397000	1.83e-01
Extension of Telomeres	51	9.52e-07	0.397000	1.13e-05
Nuclear events stimulated by ALK signaling in cancer	33	8.06e-05	0.396000	5.69e-04
FLT3 signaling through SRC family kinases	6	9.30e-02	0.396000	1.84e-01
Degradation of DVL	43	7.15e-06	0.396000	7.21e-05
TBC/RABGAPs	45	4.40e-06	0.395000	4.74e-05
NF-kB is activated and signals survival	12	1.79e-02	0.395000	5.08e-02
POLB-Dependent Long Patch Base Excision Repair	8	5.33e-02	0.394000	1.19e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	1.99e-04	0.392000	1.18e-03
Transcription of E2F targets under negative control by DREAM complex	19	3.10e-03	0.392000	1.26e-02
Transcriptional regulation of granulopoiesis	44	6.86e-06	0.392000	7.01e-05
Zinc influx into cells by the SLC39 gene family	9	4.24e-02	0.391000	1.01e-01
Packaging Of Telomere Ends	18	4.25e-03	0.389000	1.61e-02
mRNA Splicing - Minor Pathway	50	1.97e-06	0.389000	2.26e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	2.72e-05	0.388000	2.35e-04
p53-Independent DNA Damage Response	39	2.72e-05	0.388000	2.35e-04
p53-Independent G1/S DNA damage checkpoint	39	2.72e-05	0.388000	2.35e-04
Synthesis of pyrophosphates in the cytosol	8	5.90e-02	0.386000	1.28e-01
Tandem pore domain potassium channels	5	1.36e-01	0.385000	2.43e-01
Coenzyme A biosynthesis	7	7.76e-02	0.385000	1.60e-01
Peptide chain elongation	87	5.24e-10	0.385000	1.15e-08
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	3.77e-03	0.384000	1.46e-02
Signaling by FGFR2 IIIa TM	18	4.82e-03	0.384000	1.76e-02
Basigin interactions	21	2.35e-03	0.383000	9.90e-03
Suppression of phagosomal maturation	12	2.15e-02	0.383000	5.88e-02
Formation of the Early Elongation Complex	33	1.40e-04	0.383000	8.81e-04
Formation of the HIV-1 Early Elongation Complex	33	1.40e-04	0.383000	8.81e-04
NR1H2 and NR1H3-mediated signaling	38	4.64e-05	0.382000	3.60e-04
Biosynthesis of Lipoxins (LX)	6	1.05e-01	0.382000	2.02e-01
Condensation of Prophase Chromosomes	27	5.96e-04	0.382000	3.01e-03
FLT3 signaling by CBL mutants	7	8.07e-02	0.381000	1.65e-01
Leishmania infection	213	8.07e-22	0.381000	4.12e-20
Parasitic Infection Pathways	213	8.07e-22	0.381000	4.12e-20
Arachidonate production from DAG	5	1.40e-01	0.381000	2.48e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	2.13e-05	0.379000	1.90e-04
HIV Transcription Elongation	42	2.13e-05	0.379000	1.90e-04
Tat-mediated elongation of the HIV-1 transcript	42	2.13e-05	0.379000	1.90e-04
Hh mutants are degraded by ERAD	42	2.15e-05	0.379000	1.90e-04
SARS-CoV-2 modulates autophagy	11	2.96e-02	0.379000	7.55e-02
Phospholipase C-mediated cascade; FGFR2	8	6.39e-02	-0.378000	1.37e-01
FGFR2c ligand binding and activation	5	1.44e-01	-0.378000	2.51e-01
Eukaryotic Translation Elongation	92	4.03e-10	0.377000	9.24e-09
Mitochondrial translation elongation	90	6.39e-10	0.377000	1.34e-08
RND2 GTPase cycle	36	9.38e-05	0.376000	6.41e-04
Pre-NOTCH Processing in Golgi	18	5.73e-03	0.376000	2.04e-02
Heme degradation	10	3.94e-02	0.376000	9.49e-02
HDMs demethylate histones	22	2.26e-03	0.376000	9.54e-03
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	8.55e-02	0.375000	1.72e-01
NADE modulates death signalling	5	1.46e-01	0.375000	2.55e-01
ERKs are inactivated	13	1.92e-02	0.375000	5.37e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	188	7.36e-19	0.375000	3.08e-17
Advanced glycosylation endproduct receptor signaling	12	2.51e-02	0.374000	6.65e-02
DNA Damage Recognition in GG-NER	38	6.91e-05	0.373000	5.06e-04
Regulation of TP53 Activity through Association with Co-factors	13	1.99e-02	0.373000	5.52e-02
Vif-mediated degradation of APOBEC3G	41	3.70e-05	0.372000	3.01e-04
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.00e-02	0.372000	3.21e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	3.10e-05	0.371000	2.63e-04
tRNA processing in the mitochondrion	24	1.64e-03	0.371000	7.27e-03
SCF-beta-TrCP mediated degradation of Emi1	42	3.14e-05	0.371000	2.65e-04
Viral mRNA Translation	87	2.24e-09	0.371000	4.24e-08
Defective CFTR causes cystic fibrosis	47	1.09e-05	0.371000	1.04e-04
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	8.91e-04	0.369000	4.21e-03
Hh mutants abrogate ligand secretion	43	2.80e-05	0.369000	2.41e-04
SRP-dependent cotranslational protein targeting to membrane	110	2.33e-11	0.369000	5.92e-10
rRNA processing in the mitochondrion	24	1.77e-03	0.369000	7.78e-03
Repression of WNT target genes	14	1.71e-02	0.368000	4.91e-02
Mucopolysaccharidoses	11	3.46e-02	0.368000	8.64e-02
Fc epsilon receptor (FCERI) signaling	180	1.64e-17	0.368000	6.33e-16
The role of Nef in HIV-1 replication and disease pathogenesis	28	7.65e-04	0.367000	3.72e-03
Autodegradation of the E3 ubiquitin ligase COP1	38	8.90e-05	0.367000	6.15e-04
Nectin/Necl trans heterodimerization	5	1.56e-01	0.367000	2.66e-01
GDP-fucose biosynthesis	6	1.20e-01	0.367000	2.22e-01
Base Excision Repair	57	1.74e-06	0.366000	2.01e-05
Eukaryotic Translation Termination	91	1.61e-09	0.366000	3.13e-08
N-glycan antennae elongation in the medial/trans-Golgi	21	3.72e-03	0.366000	1.44e-02
Infection with Mycobacterium tuberculosis	26	1.25e-03	0.365000	5.69e-03
Signaling by the B Cell Receptor (BCR)	151	9.60e-15	0.365000	3.36e-13
Selenocysteine synthesis	91	1.79e-09	0.365000	3.41e-08
Formation of a pool of free 40S subunits	99	4.09e-10	0.363000	9.28e-09
Cross-presentation of soluble exogenous antigens (endosomes)	35	2.00e-04	0.363000	1.19e-03
Vpu mediated degradation of CD4	39	8.67e-05	0.363000	6.01e-04
EPH-ephrin mediated repulsion of cells	43	3.77e-05	0.363000	3.04e-04
Nucleotide salvage	21	3.98e-03	0.363000	1.53e-02
Heme biosynthesis	13	2.39e-02	0.362000	6.41e-02
CRMPs in Sema3A signaling	14	1.92e-02	0.361000	5.37e-02
Reactions specific to the complex N-glycan synthesis pathway	7	9.82e-02	0.361000	1.92e-01
Defective LFNG causes SCDO3	5	1.63e-01	0.360000	2.75e-01
Cardiogenesis	14	1.96e-02	0.360000	5.46e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	1.63e-01	0.360000	2.75e-01
Phenylalanine metabolism	5	1.64e-01	0.360000	2.75e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	6.80e-05	0.359000	5.00e-04
Protein hydroxylation	17	1.04e-02	0.359000	3.32e-02
RNA Polymerase I Promoter Opening	17	1.05e-02	0.359000	3.33e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	2.29e-09	0.358000	4.28e-08
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	2.97e-03	0.358000	1.20e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	2.58e-02	0.357000	6.79e-02
Formation of HIV elongation complex in the absence of HIV Tat	44	4.17e-05	0.357000	3.28e-04
UCH proteinases	73	1.34e-07	0.357000	1.88e-06
The role of GTSE1 in G2/M progression after G2 checkpoint	59	2.22e-06	0.356000	2.51e-05
SARS-CoV-1 modulates host translation machinery	36	2.21e-04	0.356000	1.29e-03
Pexophagy	10	5.17e-02	0.355000	1.17e-01
HDACs deacetylate histones	45	3.73e-05	0.355000	3.02e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	1.90e-04	0.354000	1.14e-03
Mitochondrial translation initiation	90	6.11e-09	0.354000	1.09e-07
G2 Phase	5	1.70e-01	0.354000	2.83e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	3.92e-07	0.353000	5.07e-06
Phenylalanine and tyrosine metabolism	9	6.67e-02	0.353000	1.42e-01
Metabolism of porphyrins	22	4.18e-03	0.353000	1.59e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	1.35e-01	0.353000	2.42e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	1.52e-03	0.353000	6.80e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.52e-03	0.353000	6.80e-03
RUNX2 regulates genes involved in cell migration	6	1.35e-01	0.352000	2.42e-01
Formation of the beta-catenin:TCF transactivating complex	44	5.24e-05	0.352000	4.01e-04
Mitochondrial translation termination	90	7.58e-09	0.352000	1.32e-07
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	5.21e-03	0.352000	1.87e-02
Telomere C-strand (Lagging Strand) Synthesis	34	3.81e-04	0.352000	2.09e-03
Translation of Structural Proteins 9683701	29	1.04e-03	0.352000	4.84e-03
Defects in biotin (Btn) metabolism	8	8.49e-02	0.352000	1.72e-01
Resolution of Abasic Sites (AP sites)	38	1.79e-04	0.351000	1.09e-03
Regulation of ornithine decarboxylase (ODC)	38	1.83e-04	0.351000	1.11e-03
Signaling by FGFR3 in disease	14	2.34e-02	-0.350000	6.34e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	2.47e-03	0.350000	1.03e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	6.21e-04	0.350000	3.12e-03
PKA activation in glucagon signalling	14	2.37e-02	0.349000	6.38e-02
CDH11 homotypic and heterotypic interactions	5	1.77e-01	0.349000	2.91e-01
MAPK3 (ERK1) activation	10	5.67e-02	0.348000	1.24e-01
Negative regulation of NOTCH4 signaling	44	6.58e-05	0.348000	4.86e-04
Regulation of HMOX1 expression and activity	5	1.78e-01	0.347000	2.94e-01
Influenza Viral RNA Transcription and Replication	134	3.94e-12	0.347000	1.08e-10
Ubiquitin-dependent degradation of Cyclin D	39	1.78e-04	0.347000	1.09e-03
Fibronectin matrix formation	6	1.41e-01	0.347000	2.49e-01
Phospholipase C-mediated cascade; FGFR4	6	1.43e-01	-0.345000	2.51e-01
Citric acid cycle (TCA cycle)	34	5.02e-04	0.345000	2.61e-03
Asymmetric localization of PCP proteins	49	3.00e-05	0.345000	2.57e-04
STAT3 nuclear events downstream of ALK signaling	11	4.82e-02	0.344000	1.11e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	1.45e-01	0.344000	2.52e-01
Fructose metabolism	7	1.16e-01	0.343000	2.16e-01
PCP/CE pathway	75	2.82e-07	0.343000	3.72e-06
Activation of the pre-replicative complex	32	7.88e-04	0.343000	3.80e-03
Degradation of beta-catenin by the destruction complex	72	4.95e-07	0.343000	6.19e-06
PCNA-Dependent Long Patch Base Excision Repair	21	6.70e-03	0.342000	2.29e-02
Translation of Structural Proteins 9694635	56	9.67e-06	0.342000	9.32e-05
Regulation of RUNX3 expression and activity	45	7.32e-05	0.342000	5.28e-04
Interleukin-9 signaling	8	9.46e-02	0.341000	1.86e-01
NFE2L2 regulating ER-stress associated genes	5	1.86e-01	0.341000	3.03e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	2.72e-02	0.341000	7.08e-02
L13a-mediated translational silencing of Ceruloplasmin expression	109	7.79e-10	0.341000	1.61e-08
Respiratory electron transport	149	6.97e-13	0.341000	2.10e-11
Somitogenesis	41	1.62e-04	0.340000	9.98e-04
Activation of gene expression by SREBF (SREBP)	42	1.40e-04	0.340000	8.81e-04
Eicosanoid ligand-binding receptors	13	3.50e-02	0.338000	8.72e-02
Regulation of expression of SLITs and ROBOs	148	1.31e-12	0.338000	3.76e-11
Defective Intrinsic Pathway for Apoptosis	24	4.29e-03	0.337000	1.62e-02
PTK6 promotes HIF1A stabilization	6	1.53e-01	-0.337000	2.64e-01
Late SARS-CoV-2 Infection Events	64	3.26e-06	0.336000	3.57e-05
Prostanoid ligand receptors	8	9.96e-02	0.336000	1.94e-01
PKA activation	15	2.42e-02	0.336000	6.46e-02
Base-Excision Repair, AP Site Formation	29	1.76e-03	0.336000	7.75e-03
GLI3 is processed to GLI3R by the proteasome	46	8.23e-05	0.336000	5.77e-04
PRC2 methylates histones and DNA	27	2.55e-03	0.335000	1.06e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	3.72e-03	0.335000	1.44e-02
Synthesis of PI	5	1.95e-01	0.335000	3.14e-01
Degradation of GLI2 by the proteasome	45	1.06e-04	0.334000	7.06e-04
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	11	5.52e-02	0.334000	1.22e-01
Defective EXT2 causes exostoses 2	11	5.52e-02	0.334000	1.22e-01
Lysosphingolipid and LPA receptors	11	5.53e-02	0.334000	1.22e-01
PI-3K cascade:FGFR3	10	6.78e-02	-0.334000	1.44e-01
Aerobic respiration and respiratory electron transport	245	2.30e-19	0.333000	1.03e-17
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	5.57e-02	0.333000	1.23e-01
Acyl chain remodeling of CL	5	1.97e-01	0.333000	3.17e-01
p75NTR recruits signalling complexes	12	4.58e-02	0.333000	1.07e-01
Formation of paraxial mesoderm	52	3.29e-05	0.333000	2.75e-04
Cap-dependent Translation Initiation	117	5.70e-10	0.332000	1.21e-08
Eukaryotic Translation Initiation	117	5.70e-10	0.332000	1.21e-08
Mitochondrial translation	96	1.95e-08	0.332000	3.11e-07
Degradation of AXIN	42	2.03e-04	0.331000	1.20e-03
Orc1 removal from chromatin	58	1.34e-05	0.330000	1.25e-04
Mitochondrial tRNA aminoacylation	21	8.78e-03	0.330000	2.88e-02
Hedgehog ligand biogenesis	47	9.04e-05	0.330000	6.22e-04
PI-3K cascade:FGFR2	13	3.94e-02	-0.330000	9.49e-02
Metabolism of polyamines	46	1.08e-04	0.330000	7.18e-04
Carnitine shuttle	12	4.81e-02	0.330000	1.11e-01
Nuclear events mediated by NFE2L2	82	2.50e-07	0.329000	3.40e-06
N-Glycan antennae elongation	13	4.01e-02	0.329000	9.61e-02
Ethanol oxidation	7	1.32e-01	0.329000	2.39e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	7.75e-04	0.328000	3.76e-03
Signaling by CSF1 (M-CSF) in myeloid cells	30	1.87e-03	0.328000	8.12e-03
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	7.33e-02	0.327000	1.54e-01
MASTL Facilitates Mitotic Progression	10	7.36e-02	0.327000	1.54e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	2.38e-02	0.326000	6.40e-02
Platelet sensitization by LDL	16	2.38e-02	0.326000	6.40e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	2.53e-04	0.326000	1.44e-03
Diseases associated with glycosylation precursor biosynthesis	15	2.87e-02	0.326000	7.39e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.00e-02	0.326000	5.52e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.00e-02	0.326000	5.52e-02
Influenza Infection	153	3.56e-12	0.326000	9.95e-11
DNA Double Strand Break Response	47	1.13e-04	0.326000	7.44e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	110	3.74e-09	0.325000	6.74e-08
Regulation of PTEN gene transcription	59	1.57e-05	0.325000	1.44e-04
Cellular response to chemical stress	179	6.19e-14	0.325000	2.02e-12
Beta-catenin phosphorylation cascade	17	2.04e-02	0.325000	5.63e-02
Degradation of GLI1 by the proteasome	46	1.38e-04	0.325000	8.81e-04
Late endosomal microautophagy	30	2.08e-03	0.325000	8.90e-03
Signaling by ALK	24	5.93e-03	0.324000	2.06e-02
Azathioprine ADME	20	1.20e-02	0.324000	3.71e-02
Translation	292	1.44e-21	0.324000	6.93e-20
Chromosome Maintenance	103	1.30e-08	0.324000	2.18e-07
Synthesis of IP3 and IP4 in the cytosol	22	8.54e-03	0.324000	2.82e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.82e-09	0.323000	5.13e-08
Nonsense-Mediated Decay (NMD)	113	2.82e-09	0.323000	5.13e-08
Biosynthesis of E-series 18(S)-resolvins	5	2.11e-01	0.323000	3.34e-01
CS/DS degradation	9	9.36e-02	0.323000	1.85e-01
Folding of actin by CCT/TriC	10	7.74e-02	0.323000	1.59e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	2.95e-08	0.322000	4.62e-07
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	1.56e-04	0.322000	9.68e-04
MECP2 regulates transcription factors	5	2.13e-01	-0.321000	3.36e-01
Telomere C-strand synthesis initiation	13	4.48e-02	0.321000	1.06e-01
G1/S Transition	120	1.26e-09	0.321000	2.50e-08
Mitochondrial protein degradation	96	5.63e-08	0.321000	8.35e-07
Complex I biogenesis	66	6.79e-06	0.320000	6.99e-05
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	5	2.16e-01	-0.320000	3.39e-01
STAT5 activation downstream of FLT3 ITD mutants	9	9.68e-02	0.320000	1.90e-01
Polymerase switching on the C-strand of the telomere	26	4.82e-03	0.319000	1.76e-02
Response to metal ions	6	1.76e-01	0.319000	2.90e-01
Signal transduction by L1	20	1.36e-02	0.319000	4.08e-02
Netrin mediated repulsion signals	5	2.17e-01	0.319000	3.41e-01
Regulation of Apoptosis	40	5.00e-04	0.318000	2.60e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	2.64e-04	0.318000	1.51e-03
DNA Damage/Telomere Stress Induced Senescence	42	3.68e-04	0.318000	2.02e-03
MicroRNA (miRNA) biogenesis	24	7.08e-03	0.318000	2.40e-02
Dectin-1 mediated noncanonical NF-kB signaling	48	1.41e-04	0.318000	8.85e-04
Respiratory syncytial virus (RSV) attachment and entry	19	1.67e-02	0.317000	4.86e-02
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	2.20e-01	0.317000	3.45e-01
Signaling by Retinoic Acid	29	3.21e-03	0.316000	1.29e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.04e-03	0.316000	4.84e-03
Glucagon-type ligand receptors	20	1.46e-02	0.315000	4.33e-02
Reduction of cytosolic Ca++ levels	9	1.02e-01	0.315000	1.97e-01
Regulation of TP53 Activity through Methylation	19	1.77e-02	0.314000	5.02e-02
Selenoamino acid metabolism	114	6.64e-09	0.314000	1.17e-07
Activation of the phototransduction cascade	9	1.03e-01	-0.314000	1.98e-01
Diseases of programmed cell death	58	3.56e-05	0.314000	2.92e-04
N-glycan trimming and elongation in the cis-Golgi	5	2.24e-01	0.314000	3.50e-01
Cellular response to hypoxia	59	3.06e-05	0.314000	2.61e-04
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	1.28e-02	0.314000	3.92e-02
Neurodegenerative Diseases	21	1.28e-02	0.314000	3.92e-02
PD-1 signaling	28	4.11e-03	0.313000	1.56e-02
Interconversion of nucleotide di- and triphosphates	27	4.88e-03	0.313000	1.77e-02
LDL clearance	17	2.56e-02	0.313000	6.77e-02
Formation of xylulose-5-phosphate	5	2.27e-01	0.312000	3.52e-01
Formyl peptide receptors bind formyl peptides and many other ligands	7	1.53e-01	0.312000	2.63e-01
TGFBR3 PTM regulation	10	8.85e-02	0.311000	1.77e-01
Lysosome Vesicle Biogenesis	32	2.34e-03	0.311000	9.87e-03
Translocation of ZAP-70 to Immunological synapse	24	8.39e-03	0.311000	2.78e-02
Calnexin/calreticulin cycle	26	6.12e-03	0.311000	2.12e-02
Mitotic G1 phase and G1/S transition	138	3.00e-10	0.310000	6.96e-09
Amyloid fiber formation	51	1.28e-04	0.310000	8.32e-04
RUNX1 regulates transcription of genes involved in BCR signaling	6	1.89e-01	-0.310000	3.06e-01
Serotonin Neurotransmitter Release Cycle	13	5.31e-02	0.310000	1.19e-01
Metabolism of folate and pterines	16	3.21e-02	0.309000	8.13e-02
ATF6 (ATF6-alpha) activates chaperone genes	10	9.02e-02	0.309000	1.79e-01
HDL assembly	6	1.90e-01	0.309000	3.08e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	7.42e-05	0.309000	5.33e-04
Negative feedback regulation of MAPK pathway	6	1.90e-01	0.309000	3.08e-01
Host Interactions of HIV factors	118	7.08e-09	0.308000	1.24e-07
Complex IV assembly	45	3.48e-04	0.308000	1.93e-03
Calcineurin activates NFAT	9	1.10e-01	0.307000	2.08e-01
Transcriptional regulation of brown and beige adipocyte differentiation	23	1.08e-02	0.307000	3.41e-02
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	23	1.08e-02	0.307000	3.41e-02
Synaptic adhesion-like molecules	17	2.85e-02	0.307000	7.35e-02
Cleavage of the damaged pyrimidine	27	5.84e-03	0.306000	2.06e-02
Depyrimidination	27	5.84e-03	0.306000	2.06e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	5.84e-03	0.306000	2.06e-02
STAT5 Activation	7	1.60e-01	0.306000	2.72e-01
Glycogen metabolism	22	1.29e-02	0.306000	3.93e-02
Synthesis of PIPs at the late endosome membrane	11	7.90e-02	-0.306000	1.62e-01
G1/S DNA Damage Checkpoints	54	1.03e-04	0.306000	6.87e-04
SCF(Skp2)-mediated degradation of p27/p21	50	1.86e-04	0.306000	1.12e-03
Regulation of APC/C activators between G1/S and early anaphase	68	1.32e-05	0.305000	1.23e-04
Transcriptional regulation by small RNAs	61	3.71e-05	0.305000	3.01e-04
Neutrophil degranulation	456	4.82e-29	0.305000	7.75e-27
FGFR2 alternative splicing	25	8.36e-03	0.305000	2.78e-02
Organic anion transporters	7	1.63e-01	0.305000	2.75e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	9.55e-02	0.304000	1.88e-01
ATF6 (ATF6-alpha) activates chaperones	12	6.81e-02	0.304000	1.44e-01
Chondroitin sulfate/dermatan sulfate metabolism	39	1.04e-03	0.303000	4.84e-03
Viral Messenger RNA Synthesis	44	4.97e-04	0.303000	2.59e-03
TNFR1-mediated ceramide production	6	1.98e-01	0.303000	3.18e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	2.78e-04	0.303000	1.58e-03
PI-3K cascade:FGFR4	11	8.18e-02	-0.303000	1.67e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	1.66e-01	0.303000	2.77e-01
Lagging Strand Synthesis	20	1.91e-02	0.303000	5.36e-02
Protein repair	6	1.99e-01	0.303000	3.19e-01
Ubiquinol biosynthesis	13	5.90e-02	0.302000	1.28e-01
p75NTR signals via NF-kB	15	4.28e-02	0.302000	1.01e-01
MET activates PI3K/AKT signaling	5	2.42e-01	-0.302000	3.70e-01
NIK–>noncanonical NF-kB signaling	46	3.94e-04	0.302000	2.15e-03
Proteasome assembly	51	1.91e-04	0.302000	1.14e-03
HS-GAG biosynthesis	21	1.67e-02	0.302000	4.86e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	5.07e-02	0.302000	1.15e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	4.10e-05	0.301000	3.26e-04
Fatty acids	8	1.40e-01	-0.301000	2.48e-01
TCF dependent signaling in response to WNT	152	1.53e-10	0.301000	3.65e-09
Cyclin A/B1/B2 associated events during G2/M transition	25	9.34e-03	0.300000	3.05e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	1.42e-01	0.300000	2.50e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	3.37e-05	0.300000	2.80e-04
Ketone body metabolism	8	1.42e-01	0.299000	2.50e-01
Sulfur amino acid metabolism	22	1.52e-02	0.299000	4.48e-02
Metabolism of carbohydrates	241	1.27e-15	0.299000	4.70e-14
Formation of the ternary complex, and subsequently, the 43S complex	51	2.23e-04	0.299000	1.30e-03
Cyclin A:Cdk2-associated events at S phase entry	75	7.86e-06	0.298000	7.77e-05
Beta-oxidation of pristanoyl-CoA	9	1.21e-01	0.298000	2.25e-01
PIWI-interacting RNA (piRNA) biogenesis	23	1.34e-02	0.298000	4.04e-02
KEAP1-NFE2L2 pathway	107	1.02e-07	0.298000	1.50e-06
Glucagon signaling in metabolic regulation	26	8.61e-03	0.298000	2.84e-02
Stabilization of p53	43	7.38e-04	0.297000	3.62e-03
SARS-CoV-2 modulates host translation machinery	49	3.16e-04	0.297000	1.76e-03
p38MAPK events	13	6.39e-02	0.297000	1.37e-01
Defective RIPK1-mediated regulated necrosis	7	1.74e-01	0.297000	2.88e-01
Defective pyroptosis	27	7.62e-03	0.297000	2.58e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	5.47e-02	0.297000	1.22e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	5.47e-02	0.297000	1.22e-01
p53-Dependent G1 DNA Damage Response	52	2.17e-04	0.296000	1.27e-03
p53-Dependent G1/S DNA damage checkpoint	52	2.17e-04	0.296000	1.27e-03
Induction of Cell-Cell Fusion	8	1.47e-01	0.296000	2.55e-01
Pregnenolone biosynthesis	10	1.05e-01	0.296000	2.01e-01
Synthesis of DNA	108	1.03e-07	0.296000	1.51e-06
Replacement of protamines by nucleosomes in the male pronucleus	13	6.44e-02	0.296000	1.38e-01
Paracetamol ADME	19	2.56e-02	0.296000	6.77e-02
Unfolded Protein Response (UPR)	85	2.42e-06	0.296000	2.69e-05
mRNA Capping	29	5.87e-03	0.296000	2.06e-02
CTNNB1 S33 mutants aren’t phosphorylated	15	4.75e-02	0.296000	1.10e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	4.75e-02	0.296000	1.10e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	4.75e-02	0.296000	1.10e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	4.75e-02	0.296000	1.10e-01
Signaling by CTNNB1 phospho-site mutants	15	4.75e-02	0.296000	1.10e-01
Signaling by GSK3beta mutants	15	4.75e-02	0.296000	1.10e-01
Translation initiation complex formation	58	9.89e-05	0.295000	6.64e-04
Synthesis of Ketone Bodies	6	2.10e-01	0.295000	3.33e-01
CDK-mediated phosphorylation and removal of Cdc6	60	7.57e-05	0.295000	5.40e-04
Prefoldin mediated transfer of substrate to CCT/TriC	25	1.06e-02	0.295000	3.36e-02
Metabolism of amine-derived hormones	10	1.07e-01	-0.295000	2.03e-01
Diseases of carbohydrate metabolism	29	6.11e-03	0.294000	2.12e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	9.73e-05	0.293000	6.56e-04
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	2.32e-02	0.293000	6.28e-02
DNA Replication Pre-Initiation	103	2.74e-07	0.293000	3.67e-06
Spry regulation of FGF signaling	16	4.28e-02	0.292000	1.01e-01
Cellular response to starvation	147	9.22e-10	0.292000	1.87e-08
Homology Directed Repair	110	1.16e-07	0.292000	1.67e-06
Heparan sulfate/heparin (HS-GAG) metabolism	41	1.25e-03	0.291000	5.68e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	6.92e-02	0.291000	1.46e-01
Signaling by ROBO receptors	188	5.86e-12	0.291000	1.55e-10
Regulation of gene expression by Hypoxia-inducible Factor	8	1.55e-01	0.291000	2.65e-01
Glycosaminoglycan metabolism	98	6.61e-07	0.291000	8.12e-06
Notch-HLH transcription pathway	28	7.78e-03	0.291000	2.61e-02
Cyclin E associated events during G1/S transition	73	1.81e-05	0.290000	1.64e-04
HDR through MMEJ (alt-NHEJ)	12	8.18e-02	0.290000	1.67e-01
G2/M Checkpoints	126	1.93e-08	0.290000	3.10e-07
SUMOylation of DNA replication proteins	46	6.78e-04	0.290000	3.37e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	63	7.16e-05	0.289000	5.21e-04
Mitochondrial protein import	63	7.20e-05	0.289000	5.22e-04
Purine salvage	12	8.30e-02	0.289000	1.68e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	1.23e-04	0.289000	8.03e-04
Interleukin receptor SHC signaling	23	1.65e-02	0.289000	4.79e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	7.21e-02	0.288000	1.51e-01
Modulation by Mtb of host immune system	7	1.88e-01	0.288000	3.05e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	8.49e-03	0.287000	2.81e-02
Glutamate and glutamine metabolism	12	8.50e-02	0.287000	1.72e-01
Viral Infection Pathways	775	3.22e-42	0.287000	8.87e-40
Cholesterol biosynthesis	26	1.13e-02	0.287000	3.53e-02
Noncanonical activation of NOTCH3	8	1.60e-01	0.287000	2.71e-01
Regulation of RAS by GAPs	55	2.38e-04	0.286000	1.38e-03
A tetrasaccharide linker sequence is required for GAG synthesis	18	3.54e-02	0.286000	8.80e-02
Myoclonic epilepsy of Lafora	8	1.61e-01	0.286000	2.72e-01
SARS-CoV Infections	434	1.36e-24	0.286000	1.09e-22
Plasma lipoprotein assembly, remodeling, and clearance	55	2.40e-04	0.286000	1.39e-03
DNA Replication	128	2.22e-08	0.286000	3.51e-07
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	3.63e-04	0.286000	2.01e-03
InlA-mediated entry of Listeria monocytogenes into host cells	9	1.38e-01	0.285000	2.46e-01
Gap junction trafficking	28	8.96e-03	0.285000	2.93e-02
Adenylate cyclase inhibitory pathway	11	1.02e-01	0.285000	1.96e-01
Chromatin modifications during the maternal to zygotic transition (MZT)	23	1.80e-02	0.285000	5.09e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	1.38e-04	0.284000	8.81e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	3.87e-04	0.284000	2.12e-03
Zygotic genome activation (ZGA)	5	2.71e-01	0.284000	3.99e-01
Ribosomal scanning and start codon recognition	58	1.81e-04	0.284000	1.10e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.88e-05	0.284000	1.70e-04
Regulation of signaling by CBL	22	2.12e-02	0.284000	5.81e-02
Neurofascin interactions	5	2.73e-01	-0.283000	4.01e-01
RHO GTPases activate IQGAPs	25	1.44e-02	0.283000	4.27e-02
PECAM1 interactions	12	8.99e-02	0.283000	1.79e-01
Metabolism of nucleotides	85	6.58e-06	0.283000	6.86e-05
HSF1 activation	26	1.26e-02	0.283000	3.88e-02
SUMO is conjugated to E1 (UBA2:SAE1)	5	2.74e-01	0.282000	4.02e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	1.11e-02	0.282000	3.48e-02
Displacement of DNA glycosylase by APEX1	9	1.43e-01	0.282000	2.50e-01
DNA Double-Strand Break Repair	137	1.19e-08	0.282000	2.01e-07
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	6.81e-02	0.282000	1.44e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	1.43e-04	0.282000	8.92e-04
Nucleotide Excision Repair	108	4.50e-07	0.281000	5.75e-06
CD28 dependent PI3K/Akt signaling	22	2.25e-02	0.281000	6.14e-02
Assembly of the pre-replicative complex	87	5.92e-06	0.281000	6.20e-05
Attachment and Entry 9694614	15	5.97e-02	0.281000	1.30e-01
Hedgehog ‘on’ state	66	8.02e-05	0.281000	5.68e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	1.50e-04	0.281000	9.34e-04
Hydrolysis of LPC	8	1.70e-01	-0.280000	2.82e-01
Glutathione synthesis and recycling	10	1.25e-01	0.280000	2.29e-01
Translesion Synthesis by POLH	18	4.00e-02	0.280000	9.60e-02
Attachment of GPI anchor to uPAR	7	2.00e-01	0.279000	3.20e-01
Glucose metabolism	76	2.60e-05	0.279000	2.28e-04
Inhibition of Signaling by Overexpressed EGFR	5	2.80e-01	0.279000	4.07e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	2.80e-01	0.279000	4.07e-01
Evasion by RSV of host interferon responses	20	3.12e-02	0.278000	7.92e-02
Common Pathway of Fibrin Clot Formation	13	8.25e-02	0.278000	1.68e-01
mTORC1-mediated signalling	24	1.84e-02	0.278000	5.18e-02
tRNA Aminoacylation	42	1.84e-03	0.278000	8.03e-03
Endosomal Sorting Complex Required For Transport (ESCRT)	29	9.86e-03	0.277000	3.18e-02
Formation of TC-NER Pre-Incision Complex	51	6.35e-04	0.277000	3.18e-03
Recycling pathway of L1	40	2.49e-03	0.276000	1.03e-02
Maturation of TCA enzymes and regulation of TCA cycle	20	3.24e-02	0.276000	8.20e-02
Autodegradation of Cdh1 by Cdh1:APC/C	54	4.44e-04	0.276000	2.36e-03
MTOR signalling	39	2.84e-03	0.276000	1.17e-02
DNA replication initiation	8	1.76e-01	0.276000	2.90e-01
APC/C:Cdc20 mediated degradation of Securin	55	3.98e-04	0.276000	2.16e-03
NOTCH1 Intracellular Domain Regulates Transcription	44	1.54e-03	0.276000	6.86e-03
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	2.06e-01	0.276000	3.28e-01
Infectious disease	958	1.41e-47	0.276000	6.79e-45
Switching of origins to a post-replicative state	79	2.28e-05	0.276000	2.00e-04
COPI-mediated anterograde transport	92	4.89e-06	0.276000	5.21e-05
Molybdenum cofactor biosynthesis	6	2.43e-01	0.275000	3.71e-01
RHOC GTPase cycle	71	6.17e-05	0.275000	4.61e-04
Signaling by NOTCH3	42	2.11e-03	0.274000	9.00e-03
Thrombin signalling through proteinase activated receptors (PARs)	27	1.37e-02	0.274000	4.11e-02
APC truncation mutants have impaired AXIN binding	14	7.61e-02	0.274000	1.58e-01
AXIN missense mutants destabilize the destruction complex	14	7.61e-02	0.274000	1.58e-01
Signaling by AMER1 mutants	14	7.61e-02	0.274000	1.58e-01
Signaling by APC mutants	14	7.61e-02	0.274000	1.58e-01
Signaling by AXIN mutants	14	7.61e-02	0.274000	1.58e-01
Truncations of AMER1 destabilize the destruction complex	14	7.61e-02	0.274000	1.58e-01
APC/C-mediated degradation of cell cycle proteins	75	4.16e-05	0.274000	3.28e-04
Regulation of mitotic cell cycle	75	4.16e-05	0.274000	3.28e-04
SHC-mediated cascade:FGFR2	13	8.76e-02	-0.274000	1.75e-01
Chromatin modifying enzymes	214	5.22e-12	0.274000	1.40e-10
Chromatin organization	214	5.22e-12	0.274000	1.40e-10
The NLRP3 inflammasome	16	5.83e-02	0.273000	1.27e-01
Formation of RNA Pol II elongation complex	56	4.06e-04	0.273000	2.19e-03
RNA Polymerase II Transcription Elongation	56	4.06e-04	0.273000	2.19e-03
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.47e-01	0.273000	3.75e-01
Deactivation of the beta-catenin transactivating complex	36	4.62e-03	0.273000	1.72e-02
FLT3 Signaling	38	3.65e-03	0.272000	1.42e-02
Protein folding	83	1.79e-05	0.272000	1.63e-04
HSF1-dependent transactivation	30	9.83e-03	0.272000	3.17e-02
Transport to the Golgi and subsequent modification	171	8.75e-10	0.272000	1.79e-08
COPI-dependent Golgi-to-ER retrograde traffic	90	9.13e-06	0.271000	8.89e-05
Activation of RAS in B cells	5	2.96e-01	-0.270000	4.24e-01
RHOB GTPase cycle	64	1.89e-04	0.270000	1.14e-03
G beta:gamma signalling through PLC beta	17	5.41e-02	0.270000	1.21e-01
Presynaptic function of Kainate receptors	17	5.41e-02	0.270000	1.21e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	2.98e-01	-0.269000	4.25e-01
Maple Syrup Urine Disease	5	2.98e-01	-0.269000	4.25e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	2.18e-01	0.269000	3.42e-01
HIV Infection	213	1.47e-11	0.268000	3.82e-10
Proton-coupled monocarboxylate transport	6	2.56e-01	0.268000	3.84e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	2.35e-06	0.268000	2.63e-05
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	2.56e-01	0.268000	3.84e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	2.56e-01	0.268000	3.84e-01
Thyroxine biosynthesis	5	3.00e-01	-0.268000	4.28e-01
Phosphorylation of CD3 and TCR zeta chains	27	1.62e-02	0.267000	4.75e-02
Glycolysis	68	1.38e-04	0.267000	8.81e-04
TP53 Regulates Transcription of Caspase Activators and Caspases	12	1.09e-01	0.267000	2.06e-01
Translesion synthesis by REV1	16	6.46e-02	0.267000	1.38e-01
PKA-mediated phosphorylation of CREB	17	5.69e-02	0.267000	1.25e-01
Vitamin B5 (pantothenate) metabolism	20	3.89e-02	0.267000	9.43e-02
Budding and maturation of HIV virion	26	1.87e-02	0.267000	5.24e-02
Mismatch Repair	15	7.42e-02	0.266000	1.55e-01
MAPK1 (ERK2) activation	9	1.67e-01	0.266000	2.78e-01
PTEN Regulation	127	2.28e-07	0.266000	3.12e-06
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	3.03e-01	-0.266000	4.30e-01
Signaling by NOTCH	173	1.65e-09	0.266000	3.19e-08
Role of ABL in ROBO-SLIT signaling	6	2.60e-01	0.265000	3.89e-01
FRS-mediated FGFR2 signaling	15	7.53e-02	-0.265000	1.57e-01
RHOV GTPase cycle	36	5.91e-03	0.265000	2.06e-02
Hemostasis	558	9.04e-27	0.265000	9.68e-25
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	1.20e-02	0.265000	3.71e-02
rRNA processing	213	2.77e-11	0.265000	6.85e-10
Post-chaperonin tubulin folding pathway	18	5.22e-02	0.264000	1.17e-01
Dual incision in TC-NER	63	2.86e-04	0.264000	1.62e-03
MHC class II antigen presentation	113	1.24e-06	0.264000	1.45e-05
Chaperonin-mediated protein folding	77	6.17e-05	0.264000	4.61e-04
Association of TriC/CCT with target proteins during biosynthesis	35	6.90e-03	0.264000	2.35e-02
CTLA4 inhibitory signaling	21	3.64e-02	0.264000	8.97e-02
DNA Repair	289	1.25e-14	0.263000	4.30e-13
Inositol phosphate metabolism	42	3.14e-03	0.263000	1.27e-02
RA biosynthesis pathway	13	1.01e-01	0.263000	1.95e-01
ABC transporter disorders	60	4.25e-04	0.263000	2.27e-03
Cellular responses to stress	697	2.53e-32	0.263000	5.42e-30
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	5.08e-03	0.263000	1.84e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	76	7.57e-05	0.263000	5.40e-04
Protein localization	157	1.43e-08	0.262000	2.35e-07
HCMV Late Events	67	2.11e-04	0.262000	1.24e-03
Uptake and function of anthrax toxins	11	1.34e-01	0.261000	2.41e-01
Signaling by WNT in cancer	30	1.35e-02	0.261000	4.06e-02
Linoleic acid (LA) metabolism	7	2.33e-01	0.261000	3.59e-01
Gap junction trafficking and regulation	30	1.35e-02	0.260000	4.08e-02
SHC-mediated cascade:FGFR3	10	1.54e-01	-0.260000	2.64e-01
Cytosolic sulfonation of small molecules	18	5.58e-02	0.260000	1.23e-01
RHOU GTPase cycle	40	4.44e-03	0.260000	1.67e-02
EGFR interacts with phospholipase C-gamma	6	2.70e-01	0.260000	3.99e-01
Signaling by NOTCH4	68	2.12e-04	0.260000	1.24e-03
Activation of ATR in response to replication stress	37	6.29e-03	0.260000	2.16e-02
Vesicle-mediated transport	665	3.14e-30	0.259000	5.50e-28
S Phase	150	4.23e-08	0.259000	6.52e-07
Innate Immune System	970	1.09e-42	0.259000	3.51e-40
VEGFR2 mediated vascular permeability	25	2.49e-02	0.259000	6.62e-02
Glycogen synthesis	11	1.37e-01	0.259000	2.44e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	2.73e-01	0.258000	4.01e-01
Cellular responses to stimuli	778	1.18e-34	0.258000	2.84e-32
G beta:gamma signalling through PI3Kgamma	22	3.59e-02	0.258000	8.86e-02
Inactivation of CSF3 (G-CSF) signaling	24	2.85e-02	0.258000	7.35e-02
Transport of vitamins, nucleosides, and related molecules	31	1.29e-02	0.258000	3.93e-02
Signaling by activated point mutants of FGFR1	5	3.18e-01	-0.258000	4.48e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	2.30e-02	0.258000	6.24e-02
Initiation of Nuclear Envelope (NE) Reformation	19	5.19e-02	0.258000	1.17e-01
Positive epigenetic regulation of rRNA expression	60	5.62e-04	0.257000	2.85e-03
TP53 Regulates Transcription of DNA Repair Genes	61	5.12e-04	0.257000	2.63e-03
Role of second messengers in netrin-1 signaling	6	2.76e-01	0.257000	4.03e-01
SUMOylation of immune response proteins	12	1.24e-01	0.257000	2.27e-01
Signaling by NOTCH1	66	3.13e-04	0.257000	1.76e-03
Interleukin-2 family signaling	38	6.24e-03	0.256000	2.15e-02
ER to Golgi Anterograde Transport	145	1.04e-07	0.256000	1.51e-06
The canonical retinoid cycle in rods (twilight vision)	9	1.84e-01	0.256000	3.01e-01
NFE2L2 regulating tumorigenic genes	11	1.43e-01	0.255000	2.50e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	1.28e-01	0.254000	2.32e-01
Synthesis of 5-eicosatetraenoic acids	7	2.45e-01	0.254000	3.74e-01
Sema4D mediated inhibition of cell attachment and migration	7	2.47e-01	0.253000	3.75e-01
FRS-mediated FGFR3 signaling	12	1.30e-01	-0.252000	2.36e-01
Transcriptional regulation by RUNX2	89	3.99e-05	0.252000	3.19e-04
Recognition of DNA damage by PCNA-containing replication complex	30	1.71e-02	0.252000	4.91e-02
TLR3-mediated TICAM1-dependent programmed cell death	6	2.87e-01	0.251000	4.14e-01
rRNA processing in the nucleus and cytosol	189	2.76e-09	0.251000	5.12e-08
Synthesis of wybutosine at G37 of tRNA(Phe)	6	2.89e-01	-0.250000	4.17e-01
p75 NTR receptor-mediated signalling	89	4.53e-05	0.250000	3.53e-04
HS-GAG degradation	20	5.30e-02	0.250000	1.19e-01
Cell death signalling via NRAGE, NRIF and NADE	69	3.32e-04	0.250000	1.85e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.06e-01	0.250000	2.02e-01
NRAGE signals death through JNK	52	1.83e-03	0.250000	8.01e-03
Ephrin signaling	18	6.66e-02	0.250000	1.42e-01
Regulation of CDH11 gene transcription	5	3.34e-01	0.250000	4.64e-01
Activation of BH3-only proteins	30	1.81e-02	0.249000	5.10e-02
HCMV Infection	106	9.28e-06	0.249000	8.99e-05
RORA activates gene expression	18	6.74e-02	0.249000	1.43e-01
RSK activation	7	2.54e-01	0.249000	3.83e-01
Miscellaneous substrates	8	2.23e-01	-0.249000	3.48e-01
Senescence-Associated Secretory Phenotype (SASP)	65	5.33e-04	0.248000	2.72e-03
Asparagine N-linked glycosylation	286	5.36e-13	0.248000	1.64e-11
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.56e-01	0.247000	2.67e-01
Mitochondrial biogenesis	91	4.74e-05	0.247000	3.65e-04
Acyl chain remodelling of PG	11	1.57e-01	-0.247000	2.68e-01
Interleukin-12 signaling	44	4.70e-03	0.246000	1.74e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	1.59e-02	0.246000	4.67e-02
Costimulation by the CD28 family	74	2.51e-04	0.246000	1.44e-03
Global Genome Nucleotide Excision Repair (GG-NER)	84	9.74e-05	0.246000	6.56e-04
AKT phosphorylates targets in the cytosol	14	1.12e-01	0.245000	2.10e-01
Glycogen storage diseases	13	1.26e-01	0.245000	2.30e-01
Regulation of PTEN stability and activity	55	1.66e-03	0.245000	7.37e-03
Major pathway of rRNA processing in the nucleolus and cytosol	179	1.55e-08	0.245000	2.52e-07
Frs2-mediated activation	11	1.60e-01	0.245000	2.71e-01
rRNA modification in the mitochondrion	8	2.31e-01	0.245000	3.57e-01
Pre-NOTCH Expression and Processing	63	7.90e-04	0.244000	3.80e-03
RHOA GTPase cycle	138	7.12e-07	0.244000	8.65e-06
NFE2L2 regulating inflammation associated genes	5	3.44e-01	0.244000	4.76e-01
PI-3K cascade:FGFR1	13	1.28e-01	-0.244000	2.32e-01
Cellular responses to mechanical stimuli	82	1.40e-04	0.243000	8.81e-04
Response of endothelial cells to shear stress	82	1.40e-04	0.243000	8.81e-04
GPVI-mediated activation cascade	32	1.74e-02	0.243000	4.95e-02
Mitotic Prophase	96	3.96e-05	0.243000	3.18e-04
Golgi-to-ER retrograde transport	123	3.37e-06	0.243000	3.67e-05
Regulation of MITF-M-dependent genes involved in pigmentation	38	9.67e-03	0.243000	3.13e-02
GPER1 signaling	38	9.79e-03	0.242000	3.17e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	9.36e-02	0.242000	1.85e-01
EPH-Ephrin signaling	81	1.68e-04	0.242000	1.03e-03
Regulation of IFNA/IFNB signaling	12	1.47e-01	0.242000	2.55e-01
Signaling by FGFR4 in disease	11	1.66e-01	-0.241000	2.78e-01
Synthesis of 12-eicosatetraenoic acid derivatives	6	3.06e-01	0.241000	4.34e-01
Diseases associated with glycosaminoglycan metabolism	26	3.34e-02	0.241000	8.39e-02
RHO GTPases Activate WASPs and WAVEs	35	1.37e-02	0.241000	4.11e-02
RUNX2 regulates bone development	24	4.13e-02	0.241000	9.86e-02
RNA Polymerase I Promoter Clearance	64	8.70e-04	0.241000	4.13e-03
RNA Polymerase I Transcription	64	8.70e-04	0.241000	4.13e-03
Regulation of innate immune responses to cytosolic DNA	14	1.19e-01	0.241000	2.21e-01
SARS-CoV-1-host interactions	94	5.55e-05	0.241000	4.20e-04
Generation of second messenger molecules	38	1.04e-02	0.240000	3.33e-02
SUMOylation of chromatin organization proteins	57	1.72e-03	0.240000	7.59e-03
Signaling by CSF3 (G-CSF)	29	2.55e-02	0.240000	6.75e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	3.39e-03	0.239000	1.34e-02
Transcriptional Regulation by TP53	346	1.96e-14	0.239000	6.62e-13
Synthesis of 15-eicosatetraenoic acid derivatives	6	3.11e-01	-0.239000	4.39e-01
Activation of HOX genes during differentiation	70	5.46e-04	0.239000	2.77e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	5.46e-04	0.239000	2.77e-03
Phospholipase C-mediated cascade: FGFR1	8	2.43e-01	-0.238000	3.71e-01
Androgen biosynthesis	5	3.56e-01	-0.238000	4.89e-01
G2/M Transition	177	4.93e-08	0.238000	7.37e-07
Signaling by WNT	240	2.34e-10	0.237000	5.50e-09
Fanconi Anemia Pathway	36	1.38e-02	0.237000	4.12e-02
Mitotic G2-G2/M phases	179	4.51e-08	0.237000	6.84e-07
SHC-mediated cascade:FGFR4	11	1.74e-01	-0.236000	2.88e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	2.91e-03	0.236000	1.18e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	2.91e-03	0.236000	1.18e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	2.91e-03	0.236000	1.18e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	2.91e-03	0.236000	1.18e-02
Signaling by NOTCH1 in Cancer	53	2.91e-03	0.236000	1.18e-02
Transport and synthesis of PAPS	6	3.16e-01	0.236000	4.45e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.36e-02	0.236000	8.43e-02
Transcription of the HIV genome	67	8.32e-04	0.236000	3.98e-03
Cellular Senescence	143	1.11e-06	0.236000	1.31e-05
HATs acetylate histones	92	9.28e-05	0.236000	6.37e-04
RAS processing	23	5.07e-02	0.235000	1.15e-01
Clathrin-mediated endocytosis	126	5.11e-06	0.235000	5.41e-05
ER-Phagosome pathway	75	4.32e-04	0.235000	2.30e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	1.47e-02	0.235000	4.34e-02
Cytosolic tRNA aminoacylation	24	4.64e-02	0.235000	1.08e-01
Formation of tubulin folding intermediates by CCT/TriC	21	6.24e-02	0.235000	1.35e-01
Adipogenesis	95	7.62e-05	0.235000	5.42e-04
RUNX2 regulates osteoblast differentiation	19	7.72e-02	0.234000	1.59e-01
Cell Cycle, Mitotic	488	8.32e-19	0.234000	3.41e-17
FGFRL1 modulation of FGFR1 signaling	7	2.84e-01	-0.234000	4.12e-01
Transcriptional regulation by RUNX1	170	1.50e-07	0.233000	2.06e-06
Late Phase of HIV Life Cycle	131	4.05e-06	0.233000	4.38e-05
Energy dependent regulation of mTOR by LKB1-AMPK	27	3.64e-02	0.233000	8.96e-02
FRS-mediated FGFR4 signaling	13	1.47e-01	-0.233000	2.55e-01
Metabolism of fat-soluble vitamins	28	3.34e-02	0.232000	8.40e-02
Drug ADME	57	2.44e-03	0.232000	1.02e-02
Transcriptional Regulation by E2F6	34	1.92e-02	0.232000	5.37e-02
Intrinsic Pathway for Apoptosis	54	3.25e-03	0.232000	1.30e-02
Attenuation phase	23	5.48e-02	0.231000	1.22e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	2.30e-01	0.231000	3.56e-01
Meiotic synapsis	43	8.73e-03	0.231000	2.87e-02
RNA Polymerase III Chain Elongation	18	8.97e-02	0.231000	1.79e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.66e-01	0.231000	2.78e-01
alpha-linolenic acid (ALA) metabolism	12	1.66e-01	0.231000	2.78e-01
G-protein beta:gamma signalling	29	3.16e-02	0.231000	8.02e-02
Regulation of RUNX2 expression and activity	54	3.39e-03	0.230000	1.34e-02
DNA Damage Reversal	8	2.59e-01	0.230000	3.88e-01
Beta-catenin independent WNT signaling	126	7.93e-06	0.230000	7.79e-05
Autophagy	142	2.15e-06	0.230000	2.45e-05
Mitochondrial iron-sulfur cluster biogenesis	13	1.51e-01	0.230000	2.61e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	3.53e-02	0.230000	8.78e-02
Regulation of TP53 Activity	153	9.32e-07	0.230000	1.12e-05
Nuclear Pore Complex (NPC) Disassembly	36	1.71e-02	0.230000	4.91e-02
EGFR Transactivation by Gastrin	7	2.94e-01	-0.229000	4.23e-01
Effects of PIP2 hydrolysis	24	5.20e-02	0.229000	1.17e-01
Mitochondrial RNA degradation	25	4.74e-02	0.229000	1.10e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	1.89e-01	0.229000	3.06e-01
Antimicrobial peptides	34	2.10e-02	0.229000	5.76e-02
Termination of translesion DNA synthesis	32	2.52e-02	0.229000	6.67e-02
Vasopressin regulates renal water homeostasis via Aquaporins	34	2.13e-02	0.228000	5.82e-02
Amino acids regulate mTORC1	48	6.23e-03	0.228000	2.15e-02
Cell Cycle	611	6.13e-22	0.228000	3.47e-20
Processing of DNA double-strand break ends	69	1.07e-03	0.228000	4.93e-03
Disease	1623	5.31e-53	0.228000	1.02e-49
COPII-mediated vesicle transport	67	1.27e-03	0.228000	5.76e-03
Interleukin-15 signaling	14	1.41e-01	0.227000	2.49e-01
TP53 Regulates Metabolic Genes	78	5.21e-04	0.227000	2.67e-03
Translesion synthesis by POLI	17	1.06e-01	0.226000	2.02e-01
SUMO E3 ligases SUMOylate target proteins	161	7.14e-07	0.226000	8.65e-06
Ion transport by P-type ATPases	44	9.47e-03	0.226000	3.08e-02
SUMOylation of transcription factors	16	1.17e-01	0.226000	2.19e-01
Erythropoietin activates STAT5	6	3.38e-01	0.226000	4.69e-01
G alpha (s) signalling events	96	1.33e-04	0.226000	8.62e-04
SARS-CoV-1 Infection	137	5.52e-06	0.225000	5.82e-05
HIV Life Cycle	144	3.25e-06	0.225000	3.57e-05
Macroautophagy	128	1.16e-05	0.224000	1.10e-04
Prostacyclin signalling through prostacyclin receptor	16	1.20e-01	0.224000	2.23e-01
Organic cation transport	8	2.72e-01	-0.224000	4.01e-01
Organic cation/anion/zwitterion transport	8	2.72e-01	-0.224000	4.01e-01
Semaphorin interactions	57	3.45e-03	0.224000	1.35e-02
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	3.43e-01	0.224000	4.74e-01
Activation of NF-kappaB in B cells	54	4.46e-03	0.224000	1.67e-02
Regulation of TP53 Expression and Degradation	36	2.03e-02	0.224000	5.60e-02
DCC mediated attractive signaling	13	1.63e-01	0.223000	2.75e-01
RUNX3 regulates NOTCH signaling	14	1.49e-01	0.223000	2.57e-01
RNA Polymerase I Transcription Initiation	47	8.30e-03	0.223000	2.77e-02
OAS antiviral response	8	2.76e-01	-0.222000	4.03e-01
RAF-independent MAPK1/3 activation	22	7.09e-02	0.222000	1.49e-01
Metabolism of amino acids and derivatives	305	2.43e-11	0.222000	6.08e-10
Intra-Golgi and retrograde Golgi-to-ER traffic	191	1.20e-07	0.222000	1.71e-06
CD28 co-stimulation	33	2.75e-02	0.222000	7.13e-02
Oncogene Induced Senescence	33	2.78e-02	0.221000	7.18e-02
Regulation of TP53 Degradation	35	2.35e-02	0.221000	6.34e-02
SARS-CoV-2 Infection	267	4.94e-10	0.221000	1.09e-08
Defective B3GALT6 causes EDSP2 and SEMDJL1	12	1.85e-01	0.221000	3.02e-01
Dual Incision in GG-NER	41	1.45e-02	0.221000	4.32e-02
Interleukin-12 family signaling	53	5.48e-03	0.221000	1.96e-02
ERK/MAPK targets	22	7.45e-02	0.220000	1.55e-01
Oxidative Stress Induced Senescence	77	8.69e-04	0.219000	4.13e-03
Hedgehog ‘off’ state	92	2.75e-04	0.219000	1.56e-03
MAP2K and MAPK activation	36	2.27e-02	0.219000	6.18e-02
Cargo concentration in the ER	31	3.47e-02	0.219000	8.64e-02
Regulation of pyruvate metabolism	32	3.19e-02	0.219000	8.08e-02
Signaling by Nuclear Receptors	210	4.35e-08	0.219000	6.65e-07
Pyruvate metabolism	44	1.21e-02	0.219000	3.71e-02
Acetylcholine binding and downstream events	5	3.97e-01	0.219000	5.31e-01
Postsynaptic nicotinic acetylcholine receptors	5	3.97e-01	0.219000	5.31e-01
Zinc transporters	12	1.91e-01	0.218000	3.09e-01
Sema3A PAK dependent Axon repulsion	16	1.31e-01	0.218000	2.37e-01
ABC-family proteins mediated transport	81	7.09e-04	0.218000	3.49e-03
Defective B4GALT7 causes EDS, progeroid type	12	1.92e-01	0.218000	3.10e-01
RHO GTPases activate PKNs	46	1.10e-02	0.217000	3.45e-02
Signaling by ALK fusions and activated point mutants	89	4.18e-04	0.216000	2.24e-03
Signaling by ALK in cancer	89	4.18e-04	0.216000	2.24e-03
Trafficking of GluR2-containing AMPA receptors	11	2.14e-01	0.216000	3.38e-01
Collagen biosynthesis and modifying enzymes	46	1.12e-02	0.216000	3.50e-02
AURKA Activation by TPX2	72	1.55e-03	0.216000	6.92e-03
VEGF binds to VEGFR leading to receptor dimerization	5	4.04e-01	0.216000	5.38e-01
VEGF ligand-receptor interactions	5	4.04e-01	0.216000	5.38e-01
SUMOylation	167	1.52e-06	0.216000	1.78e-05
SUMOylation of transcription cofactors	44	1.34e-02	0.215000	4.05e-02
Acetylcholine regulates insulin secretion	9	2.64e-01	0.215000	3.93e-01
ER Quality Control Compartment (ERQC)	21	8.80e-02	0.215000	1.76e-01
Metabolism	1827	1.09e-52	0.215000	1.05e-49
Acyl chain remodelling of PS	14	1.64e-01	-0.215000	2.75e-01
Mitotic Telophase/Cytokinesis	13	1.80e-01	0.215000	2.95e-01
Erythropoietin activates RAS	13	1.80e-01	0.215000	2.95e-01
DNA Damage Bypass	47	1.10e-02	0.214000	3.45e-02
Aspartate and asparagine metabolism	9	2.66e-01	-0.214000	3.94e-01
Rab regulation of trafficking	121	4.76e-05	0.214000	3.65e-04
Metabolism of proteins	1775	8.95e-51	0.214000	5.75e-48
Retinoid metabolism and transport	25	6.49e-02	0.213000	1.39e-01
HCMV Early Events	84	7.34e-04	0.213000	3.61e-03
Downstream signaling of activated FGFR2	20	9.98e-02	-0.213000	1.94e-01
Cell Cycle Checkpoints	246	9.36e-09	0.212000	1.61e-07
Pre-NOTCH Transcription and Translation	47	1.18e-02	0.212000	3.64e-02
Signalling to RAS	19	1.10e-01	0.212000	2.07e-01
Ribavirin ADME	11	2.24e-01	0.212000	3.50e-01
Fructose catabolism	5	4.13e-01	0.211000	5.46e-01
Activation of SMO	14	1.72e-01	0.211000	2.85e-01
Platelet calcium homeostasis	22	8.70e-02	0.211000	1.74e-01
Synthesis of substrates in N-glycan biosythesis	59	5.18e-03	0.210000	1.86e-02
Activation of kainate receptors upon glutamate binding	26	6.35e-02	0.210000	1.37e-01
Signaling by Hedgehog	121	6.50e-05	0.210000	4.82e-04
NRIF signals cell death from the nucleus	15	1.59e-01	0.210000	2.70e-01
Estrogen-dependent gene expression	96	3.92e-04	0.209000	2.14e-03
Resolution of D-Loop Structures	35	3.26e-02	0.209000	8.23e-02
TNFR2 non-canonical NF-kB pathway	84	9.44e-04	0.209000	4.45e-03
Interleukin-20 family signaling	17	1.38e-01	0.208000	2.45e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	2.12e-01	0.208000	3.35e-01
Transport of connexons to the plasma membrane	12	2.12e-01	0.208000	3.35e-01
Signaling by high-kinase activity BRAF mutants	33	3.90e-02	0.208000	9.43e-02
Recycling of eIF2:GDP	8	3.09e-01	0.208000	4.37e-01
Adaptive Immune System	771	1.24e-22	0.207000	7.70e-21
The activation of arylsulfatases	10	2.57e-01	0.207000	3.85e-01
Release of apoptotic factors from the mitochondria	6	3.80e-01	0.207000	5.15e-01
Mitophagy	38	2.73e-02	0.207000	7.08e-02
M Phase	346	3.75e-11	0.207000	9.15e-10
Meiotic recombination	37	2.95e-02	0.207000	7.53e-02
RHO GTPases Activate Formins	128	5.42e-05	0.207000	4.12e-04
Sealing of the nuclear envelope (NE) by ESCRT-III	24	8.00e-02	0.206000	1.64e-01
SARS-CoV-1 activates/modulates innate immune responses	40	2.39e-02	0.206000	6.41e-02
PKMTs methylate histone lysines	43	1.94e-02	0.206000	5.41e-02
Factors involved in megakaryocyte development and platelet production	129	5.35e-05	0.206000	4.07e-04
InlB-mediated entry of Listeria monocytogenes into host cell	12	2.17e-01	0.206000	3.41e-01
Synthesis of PIPs at the Golgi membrane	16	1.54e-01	0.206000	2.65e-01
NoRC negatively regulates rRNA expression	60	5.89e-03	0.206000	2.06e-02
Kinesins	51	1.11e-02	0.205000	3.48e-02
Regulation of endogenous retroelements	93	6.19e-04	0.205000	3.12e-03
Downstream TCR signaling	89	8.13e-04	0.205000	3.90e-03
RHO GTPase Effectors	259	1.31e-08	0.205000	2.18e-07
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	1.22e-01	0.205000	2.25e-01
Smooth Muscle Contraction	34	3.92e-02	0.204000	9.46e-02
Negative regulation of MAPK pathway	42	2.21e-02	0.204000	6.02e-02
Thromboxane signalling through TP receptor	20	1.15e-01	0.203000	2.16e-01
Inflammasomes	21	1.07e-01	0.203000	2.04e-01
Signaling by Leptin	10	2.67e-01	0.203000	3.95e-01
Norepinephrine Neurotransmitter Release Cycle	12	2.24e-01	0.203000	3.50e-01
ADP signalling through P2Y purinoceptor 1	21	1.08e-01	0.202000	2.05e-01
Synthesis of PIPs at the early endosome membrane	16	1.62e-01	-0.202000	2.73e-01
Aggrephagy	34	4.16e-02	0.202000	9.92e-02
Reversal of alkylation damage by DNA dioxygenases	7	3.55e-01	0.202000	4.87e-01
Sema4D in semaphorin signaling	22	1.01e-01	0.202000	1.96e-01
CaM pathway	28	6.46e-02	0.202000	1.38e-01
Calmodulin induced events	28	6.46e-02	0.202000	1.38e-01
Translesion synthesis by POLK	17	1.50e-01	0.202000	2.59e-01
G alpha (12/13) signalling events	68	4.03e-03	0.202000	1.54e-02
Mitotic Metaphase and Anaphase	212	4.14e-07	0.202000	5.32e-06
CLEC7A (Dectin-1) signaling	86	1.23e-03	0.202000	5.60e-03
Transcriptional regulation of white adipocyte differentiation	77	2.24e-03	0.201000	9.47e-03
Presynaptic depolarization and calcium channel opening	8	3.24e-01	-0.201000	4.53e-01
ADORA2B mediated anti-inflammatory cytokines production	36	3.66e-02	0.201000	8.98e-02
Alpha-oxidation of phytanate	6	3.94e-01	0.201000	5.29e-01
Membrane Trafficking	574	1.96e-16	0.201000	7.40e-15
Gene Silencing by RNA	87	1.22e-03	0.201000	5.56e-03
Mitotic Anaphase	211	5.12e-07	0.201000	6.36e-06
Regulation of MECP2 expression and activity	29	6.20e-02	0.200000	1.34e-01
Signaling by Erythropoietin	24	8.97e-02	0.200000	1.79e-01
Platelet homeostasis	69	4.07e-03	0.200000	1.55e-02
Separation of Sister Chromatids	168	7.86e-06	0.200000	7.77e-05
Selective autophagy	77	2.46e-03	0.200000	1.03e-02
Transcriptional regulation by RUNX3	80	2.03e-03	0.200000	8.72e-03
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	9.78e-02	0.199000	1.91e-01
Immune System	1841	1.04e-45	0.199000	4.01e-43
Apoptotic cleavage of cell adhesion proteins	8	3.30e-01	-0.199000	4.59e-01
Keratan sulfate/keratin metabolism	28	6.87e-02	0.199000	1.45e-01
RUNX3 regulates p14-ARF	10	2.77e-01	0.199000	4.03e-01
Rev-mediated nuclear export of HIV RNA	35	4.19e-02	0.199000	9.99e-02
Downstream signaling events of B Cell Receptor (BCR)	68	4.62e-03	0.199000	1.72e-02
Plasma lipoprotein assembly	10	2.77e-01	0.199000	4.03e-01
Keratan sulfate biosynthesis	20	1.25e-01	0.198000	2.29e-01
RHOD GTPase cycle	49	1.64e-02	0.198000	4.77e-02
EPHB-mediated forward signaling	40	3.01e-02	0.198000	7.66e-02
Molecules associated with elastic fibres	26	8.11e-02	0.198000	1.65e-01
RNA Polymerase II Pre-transcription Events	77	2.71e-03	0.198000	1.12e-02
Regulation of localization of FOXO transcription factors	12	2.36e-01	0.197000	3.63e-01
Downregulation of ERBB2 signaling	24	9.43e-02	0.197000	1.86e-01
Receptor Mediated Mitophagy	11	2.57e-01	0.197000	3.86e-01
VEGFA-VEGFR2 Pathway	92	1.09e-03	0.197000	5.04e-03
Interactions of Vpr with host cellular proteins	37	3.83e-02	0.197000	9.34e-02
Negative epigenetic regulation of rRNA expression	63	7.07e-03	0.196000	2.40e-02
TP53 Regulates Transcription of Cell Death Genes	43	2.61e-02	0.196000	6.85e-02
EGFR downregulation	26	8.39e-02	0.196000	1.70e-01
Detoxification of Reactive Oxygen Species	30	6.38e-02	0.195000	1.37e-01
Axon guidance	459	7.18e-13	0.195000	2.13e-11
PI5P Regulates TP53 Acetylation	8	3.39e-01	0.195000	4.70e-01
Interleukin-7 signaling	21	1.22e-01	0.195000	2.25e-01
HDR through Homologous Recombination (HRR)	68	5.50e-03	0.195000	1.96e-02
Respiratory Syncytial Virus Infection Pathway	99	8.27e-04	0.194000	3.96e-03
Mitochondrial calcium ion transport	22	1.14e-01	0.194000	2.15e-01
Downstream signaling of activated FGFR3	17	1.66e-01	-0.194000	2.78e-01
Phase 3 - rapid repolarisation	6	4.11e-01	-0.194000	5.45e-01
Regulation of KIT signaling	15	1.94e-01	0.194000	3.13e-01
Signaling by VEGF	99	8.79e-04	0.193000	4.16e-03
E3 ubiquitin ligases ubiquitinate target proteins	51	1.69e-02	0.193000	4.88e-02
EPHA-mediated growth cone collapse	21	1.25e-01	0.193000	2.29e-01
Cargo recognition for clathrin-mediated endocytosis	87	1.87e-03	0.193000	8.14e-03
mRNA Splicing - Major Pathway	203	2.26e-06	0.192000	2.54e-05
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	2.70e-01	-0.192000	3.99e-01
PLC beta mediated events	40	3.57e-02	0.192000	8.84e-02
Elastic fibre formation	33	5.65e-02	0.192000	1.24e-01
RHO GTPases activate CIT	18	1.59e-01	0.192000	2.70e-01
Loss of Nlp from mitotic centrosomes	69	5.86e-03	0.192000	2.06e-02
Loss of proteins required for interphase microtubule organization from the centrosome	69	5.86e-03	0.192000	2.06e-02
RUNX1 regulates transcription of genes involved in WNT signaling	5	4.58e-01	0.192000	5.89e-01
Signal regulatory protein family interactions	13	2.32e-01	0.191000	3.59e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	1.85e-01	0.191000	3.02e-01
Maternal to zygotic transition (MZT)	72	5.10e-03	0.191000	1.84e-02
Acetylcholine Neurotransmitter Release Cycle	10	2.96e-01	0.191000	4.24e-01
FRS-mediated FGFR1 signaling	15	2.01e-01	-0.191000	3.21e-01
MAPK1/MAPK3 signaling	231	6.08e-07	0.190000	7.51e-06
Antigen processing-Cross presentation	89	1.90e-03	0.190000	8.21e-03
Glycosphingolipid catabolism	31	6.67e-02	0.190000	1.42e-01
HIV Transcription Initiation	45	2.73e-02	0.190000	7.08e-02
RNA Polymerase II HIV Promoter Escape	45	2.73e-02	0.190000	7.08e-02
RNA Polymerase II Promoter Escape	45	2.73e-02	0.190000	7.08e-02
RNA Polymerase II Transcription Initiation	45	2.73e-02	0.190000	7.08e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	2.73e-02	0.190000	7.08e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	2.73e-02	0.190000	7.08e-02
TP53 Regulates Transcription of Death Receptors and Ligands	12	2.54e-01	0.190000	3.83e-01
Nervous system development	478	1.06e-12	0.190000	3.10e-11
SARS-CoV-2-host interactions	182	9.96e-06	0.190000	9.53e-05
RNA Polymerase II Transcription Termination	66	7.66e-03	0.190000	2.58e-02
Processing of Capped Intronless Pre-mRNA	29	7.71e-02	0.190000	1.59e-01
Diseases associated with N-glycosylation of proteins	20	1.42e-01	0.190000	2.50e-01
Prolonged ERK activation events	13	2.37e-01	0.190000	3.63e-01
Diseases of signal transduction by growth factor receptors and second messengers	401	7.34e-11	0.189000	1.77e-09
Nuclear Envelope (NE) Reassembly	68	6.90e-03	0.189000	2.35e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	34	5.63e-02	0.189000	1.24e-01
B-WICH complex positively regulates rRNA expression	45	2.84e-02	0.189000	7.34e-02
Regulation of lipid metabolism by PPARalpha	107	7.58e-04	0.188000	3.71e-03
Downstream signaling of activated FGFR1	22	1.26e-01	-0.188000	2.30e-01
Metabolism of RNA	717	8.11e-18	0.188000	3.19e-16
Centrosome maturation	81	3.38e-03	0.188000	1.34e-02
Recruitment of mitotic centrosome proteins and complexes	81	3.38e-03	0.188000	1.34e-02
Caspase activation via Dependence Receptors in the absence of ligand	9	3.29e-01	0.188000	4.58e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.11e-01	0.188000	2.09e-01
Bacterial Infection Pathways	65	8.77e-03	0.188000	2.88e-02
SUMOylation of RNA binding proteins	47	2.58e-02	0.188000	6.79e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	35	5.45e-02	0.188000	1.21e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	3.58e-01	0.188000	4.90e-01
FGFR2 mutant receptor activation	23	1.19e-01	0.188000	2.21e-01
Apoptosis	158	4.70e-05	0.188000	3.64e-04
Mitochondrial Fatty Acid Beta-Oxidation	36	5.16e-02	0.187000	1.17e-01
Intracellular signaling by second messengers	267	1.34e-07	0.187000	1.88e-06
SHC-mediated cascade:FGFR1	13	2.42e-01	-0.187000	3.70e-01
RND3 GTPase cycle	35	5.51e-02	0.187000	1.22e-01
Carboxyterminal post-translational modifications of tubulin	34	5.90e-02	0.187000	1.28e-01
Meiosis	67	8.08e-03	0.187000	2.70e-02
TCR signaling	110	6.98e-04	0.187000	3.45e-03
Recruitment of NuMA to mitotic centrosomes	88	2.45e-03	0.187000	1.03e-02
G2/M DNA damage checkpoint	66	8.67e-03	0.187000	2.86e-02
Listeria monocytogenes entry into host cells	17	1.82e-01	0.187000	2.98e-01
Leading Strand Synthesis	14	2.26e-01	0.187000	3.52e-01
Polymerase switching	14	2.26e-01	0.187000	3.52e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	4.64e-02	0.187000	1.08e-01
Nucleosome assembly	38	4.64e-02	0.187000	1.08e-01
Interactions of Rev with host cellular proteins	37	4.95e-02	0.187000	1.14e-01
Nicotinamide salvaging	16	1.96e-01	-0.187000	3.16e-01
PIP3 activates AKT signaling	234	8.92e-07	0.186000	1.07e-05
tRNA processing in the nucleus	59	1.33e-02	0.186000	4.03e-02
Metabolism of cofactors	25	1.08e-01	0.186000	2.05e-01
Other semaphorin interactions	16	1.99e-01	0.186000	3.19e-01
Interleukin-18 signaling	6	4.32e-01	0.185000	5.64e-01
CD163 mediating an anti-inflammatory response	9	3.36e-01	0.185000	4.67e-01
Nuclear import of Rev protein	34	6.17e-02	0.185000	1.34e-01
RAF/MAP kinase cascade	225	1.73e-06	0.185000	2.00e-05
Death Receptor Signaling	145	1.21e-04	0.185000	7.95e-04
Neddylation	216	3.02e-06	0.184000	3.35e-05
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	3.13e-01	0.184000	4.41e-01
Signaling by TGFBR3	39	4.66e-02	0.184000	1.09e-01
RHO GTPases Activate NADPH Oxidases	22	1.36e-01	0.184000	2.43e-01
RSV-host interactions	78	5.04e-03	0.184000	1.83e-02
Nuclear Envelope Breakdown	53	2.08e-02	0.184000	5.71e-02
Collagen formation	64	1.11e-02	0.184000	3.48e-02
Biosynthesis of DHA-derived SPMs	14	2.34e-01	0.184000	3.61e-01
Regulation of gene expression in beta cells	8	3.69e-01	-0.184000	5.04e-01
RHOF GTPase cycle	38	5.07e-02	0.183000	1.15e-01
Downstream signaling of activated FGFR4	18	1.79e-01	-0.183000	2.94e-01
ARMS-mediated activation	6	4.39e-01	-0.183000	5.71e-01
Downregulation of ERBB2:ERBB3 signaling	12	2.74e-01	0.182000	4.02e-01
Post-translational protein modification	1245	2.70e-27	0.182000	3.72e-25
Regulation of PLK1 Activity at G2/M Transition	87	3.32e-03	0.182000	1.33e-02
Bicarbonate transporters	9	3.45e-01	0.182000	4.76e-01
Regulation of CDH11 function	9	3.45e-01	0.182000	4.76e-01
Interleukin-27 signaling	11	2.97e-01	0.182000	4.25e-01
Biosynthesis of specialized proresolving mediators (SPMs)	16	2.09e-01	0.181000	3.32e-01
DARPP-32 events	22	1.41e-01	0.181000	2.49e-01
Ca-dependent events	30	8.61e-02	0.181000	1.73e-01
PPARA activates gene expression	105	1.36e-03	0.181000	6.13e-03
TNFs bind their physiological receptors	25	1.19e-01	0.180000	2.21e-01
FasL/ CD95L signaling	5	4.85e-01	0.180000	6.11e-01
mRNA Splicing	211	6.76e-06	0.180000	6.99e-05
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	3.03e-01	0.179000	4.30e-01
SIRT1 negatively regulates rRNA expression	22	1.45e-01	0.179000	2.53e-01
Diseases of glycosylation	110	1.15e-03	0.179000	5.26e-03
RHOT2 GTPase cycle	7	4.12e-01	0.179000	5.46e-01
Axonal growth inhibition (RHOA activation)	7	4.13e-01	0.179000	5.46e-01
p75NTR regulates axonogenesis	7	4.13e-01	0.179000	5.46e-01
Defective B3GAT3 causes JDSSDHD	12	2.84e-01	0.179000	4.12e-01
Cytosolic sensors of pathogen-associated DNA	63	1.42e-02	0.179000	4.24e-02
Protein ubiquitination	71	9.36e-03	0.178000	3.05e-02
Receptor-type tyrosine-protein phosphatases	11	3.06e-01	-0.178000	4.34e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	1.39e-01	0.178000	2.47e-01
Formation of the Editosome	6	4.51e-01	-0.178000	5.82e-01
mRNA Editing: C to U Conversion	6	4.51e-01	-0.178000	5.82e-01
Maturation of hRSV A proteins	13	2.67e-01	0.178000	3.96e-01
Disorders of transmembrane transporters	136	3.49e-04	0.178000	1.93e-03
RHOG GTPase cycle	70	1.03e-02	0.177000	3.28e-02
Mitotic Prometaphase	193	2.14e-05	0.177000	1.90e-04
Deubiquitination	225	4.53e-06	0.177000	4.85e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	623	4.17e-14	0.177000	1.38e-12
Processing of Capped Intron-Containing Pre-mRNA	279	3.55e-07	0.177000	4.66e-06
Resolution of Sister Chromatid Cohesion	116	9.92e-04	0.177000	4.66e-03
Mitochondrial Uncoupling	6	4.53e-01	0.177000	5.84e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	4.48e-02	0.177000	1.06e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	5.02e-02	0.177000	1.15e-01
Signaling by RAS mutants	41	5.02e-02	0.177000	1.15e-01
Signaling by moderate kinase activity BRAF mutants	41	5.02e-02	0.177000	1.15e-01
Signaling downstream of RAS mutants	41	5.02e-02	0.177000	1.15e-01
Metabolism of vitamins and cofactors	167	8.35e-05	0.176000	5.83e-04
COPI-independent Golgi-to-ER retrograde traffic	45	4.08e-02	0.176000	9.79e-02
G-protein mediated events	44	4.32e-02	0.176000	1.02e-01
PDH complex synthesizes acetyl-CoA from PYR	5	4.96e-01	0.176000	6.23e-01
Regulation of NF-kappa B signaling	18	1.97e-01	0.176000	3.17e-01
Programmed Cell Death	187	3.45e-05	0.176000	2.85e-04
Metabolism of steroids	123	7.81e-04	0.175000	3.78e-03
STING mediated induction of host immune responses	15	2.40e-01	0.175000	3.68e-01
Cyclin D associated events in G1	47	3.77e-02	0.175000	9.20e-02
G1 Phase	47	3.77e-02	0.175000	9.20e-02
NOTCH3 Intracellular Domain Regulates Transcription	20	1.75e-01	0.175000	2.89e-01
RHO GTPases activate KTN1	11	3.15e-01	0.175000	4.44e-01
Platelet activation, signaling and aggregation	221	7.49e-06	0.175000	7.51e-05
Cellular response to heat stress	94	3.40e-03	0.175000	1.34e-02
E2F mediated regulation of DNA replication	22	1.56e-01	0.175000	2.67e-01
PI3K events in ERBB4 signaling	6	4.59e-01	-0.175000	5.89e-01
AKT phosphorylates targets in the nucleus	10	3.40e-01	0.174000	4.71e-01
Formation of WDR5-containing histone-modifying complexes	42	5.11e-02	0.174000	1.16e-01
SUMOylation of DNA damage response and repair proteins	77	8.33e-03	0.174000	2.77e-02
Erythrocytes take up carbon dioxide and release oxygen	11	3.19e-01	0.174000	4.48e-01
O2/CO2 exchange in erythrocytes	11	3.19e-01	0.174000	4.48e-01
Chaperone Mediated Autophagy	20	1.79e-01	0.173000	2.94e-01
G beta:gamma signalling through BTK	15	2.45e-01	0.173000	3.74e-01
RNA Polymerase I Promoter Escape	45	4.43e-02	0.173000	1.05e-01
Digestion and absorption	7	4.28e-01	0.173000	5.61e-01
Signaling by Rho GTPases	607	3.09e-13	0.173000	9.61e-12
Interleukin-1 processing	8	3.96e-01	0.173000	5.31e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	1.07e-01	0.173000	2.04e-01
Protein methylation	15	2.47e-01	0.173000	3.75e-01
Glutathione conjugation	27	1.21e-01	0.172000	2.25e-01
Peroxisomal protein import	58	2.34e-02	0.172000	6.33e-02
SUMOylation of SUMOylation proteins	35	7.86e-02	0.172000	1.62e-01
Formation of definitive endoderm	9	3.73e-01	-0.172000	5.07e-01
Transport of Mature Transcript to Cytoplasm	81	7.62e-03	0.172000	2.58e-02
Crosslinking of collagen fibrils	13	2.85e-01	-0.171000	4.12e-01
RHOQ GTPase cycle	54	2.95e-02	0.171000	7.53e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	3.26e-01	0.171000	4.55e-01
CDC42 GTPase cycle	140	4.92e-04	0.171000	2.58e-03
Interleukin-1 signaling	99	3.36e-03	0.171000	1.34e-02
Cell junction organization	78	9.35e-03	0.170000	3.05e-02
IRF3-mediated induction of type I IFN	12	3.07e-01	0.170000	4.35e-01
Peroxisomal lipid metabolism	27	1.26e-01	0.170000	2.30e-01
mRNA 3’-end processing	57	2.65e-02	0.170000	6.96e-02
Depolymerization of the Nuclear Lamina	15	2.55e-01	0.170000	3.84e-01
Interleukin-35 Signalling	12	3.09e-01	0.170000	4.37e-01
PI3K/AKT activation	8	4.06e-01	0.170000	5.41e-01
Developmental Biology	924	2.42e-18	0.169000	9.71e-17
Nef mediated downregulation of MHC class I complex cell surface expression	10	3.54e-01	0.169000	4.85e-01
Signalling to ERKs	32	9.84e-02	0.169000	1.92e-01
EML4 and NUDC in mitotic spindle formation	107	2.61e-03	0.168000	1.08e-02
Signaling by Non-Receptor Tyrosine Kinases	47	4.59e-02	0.168000	1.07e-01
Signaling by PTK6	47	4.59e-02	0.168000	1.07e-01
Interleukin-1 family signaling	127	1.07e-03	0.168000	4.93e-03
Erythropoietin activates Phospholipase C gamma (PLCG)	6	4.76e-01	0.168000	6.02e-01
Biosynthesis of maresins	6	4.77e-01	0.167000	6.03e-01
Transcriptional activation of mitochondrial biogenesis	52	3.68e-02	0.167000	9.01e-02
Intra-Golgi traffic	43	5.81e-02	0.167000	1.27e-01
Downstream signal transduction	27	1.34e-01	0.167000	2.41e-01
Regulated proteolysis of p75NTR	11	3.39e-01	0.167000	4.70e-01
DAG and IP3 signaling	34	9.33e-02	0.166000	1.85e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	5.20e-01	0.166000	6.45e-01
MAPK6/MAPK4 signaling	69	1.71e-02	0.166000	4.91e-02
mRNA decay by 3’ to 5’ exoribonuclease	13	3.01e-01	0.166000	4.28e-01
Cellular response to mitochondrial stress	9	3.90e-01	0.165000	5.24e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	8.67e-02	0.165000	1.74e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	6.64e-03	0.165000	2.28e-02
Amplification of signal from the kinetochores	91	6.64e-03	0.165000	2.28e-02
Circadian Clock	67	2.00e-02	0.164000	5.52e-02
Gastrulation	76	1.33e-02	0.164000	4.03e-02
Signal attenuation	9	3.95e-01	0.164000	5.29e-01
Sphingolipid de novo biosynthesis	35	9.37e-02	0.164000	1.85e-01
Phosphate bond hydrolysis by NUDT proteins	7	4.53e-01	0.164000	5.85e-01
Butyrophilin (BTN) family interactions	10	3.70e-01	-0.164000	5.05e-01
Platelet degranulation	105	3.94e-03	0.163000	1.51e-02
TGF-beta receptor signaling activates SMADs	45	5.96e-02	0.162000	1.30e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.74e-02	0.162000	4.95e-02
G beta:gamma signalling through CDC42	17	2.49e-01	0.161000	3.77e-01
Class I peroxisomal membrane protein import	20	2.11e-01	0.161000	3.35e-01
ESR-mediated signaling	157	4.83e-04	0.161000	2.54e-03
Downregulation of ERBB4 signaling	8	4.30e-01	0.161000	5.63e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	2.80e-01	0.161000	4.07e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	2.64e-03	0.161000	1.09e-02
IRAK2 mediated activation of TAK1 complex	10	3.78e-01	0.161000	5.14e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	7.14e-02	0.161000	1.50e-01
Signaling by RAF1 mutants	37	9.15e-02	0.160000	1.82e-01
Interleukin-37 signaling	19	2.26e-01	0.160000	3.52e-01
Export of Viral Ribonucleoproteins from Nucleus	33	1.11e-01	0.160000	2.09e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	4.64e-01	0.160000	5.93e-01
Diseases of metabolism	204	8.23e-05	0.160000	5.77e-04
RNA Polymerase III Transcription Initiation	36	9.76e-02	0.160000	1.91e-01
tRNA processing	128	1.83e-03	0.159000	8.01e-03
Nonhomologous End-Joining (NHEJ)	40	8.10e-02	0.159000	1.65e-01
Activation of BAD and translocation to mitochondria	15	2.85e-01	0.159000	4.13e-01
Opioid Signalling	75	1.72e-02	0.159000	4.91e-02
Signal amplification	28	1.46e-01	0.159000	2.54e-01
LGI-ADAM interactions	9	4.10e-01	0.158000	5.45e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	3.23e-01	0.158000	4.53e-01
Metal ion SLC transporters	19	2.33e-01	0.158000	3.60e-01
Epigenetic regulation of gene expression	264	9.99e-06	0.158000	9.53e-05
RAB GEFs exchange GTP for GDP on RABs	88	1.05e-02	0.158000	3.33e-02
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	5.03e-01	0.158000	6.29e-01
Ub-specific processing proteases	153	7.61e-04	0.158000	3.71e-03
Signaling by FGFR	73	1.99e-02	0.158000	5.52e-02
Early Phase of HIV Life Cycle	14	3.07e-01	0.158000	4.35e-01
Killing mechanisms	10	3.88e-01	0.158000	5.23e-01
WNT5:FZD7-mediated leishmania damping	10	3.88e-01	0.158000	5.23e-01
TRAF3-dependent IRF activation pathway	13	3.27e-01	0.157000	4.56e-01
Transport of the SLBP Dependant Mature mRNA	36	1.03e-01	0.157000	1.98e-01
Defects in vitamin and cofactor metabolism	21	2.13e-01	0.157000	3.36e-01
Activation of C3 and C5	7	4.72e-01	0.157000	5.98e-01
CLEC7A (Dectin-1) induces NFAT activation	11	3.68e-01	0.157000	5.03e-01
Glycosphingolipid metabolism	46	6.59e-02	0.157000	1.40e-01
RNA Polymerase III Transcription Termination	22	2.03e-01	0.157000	3.24e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	9	4.16e-01	0.157000	5.49e-01
Formation of the active cofactor, UDP-glucuronate	5	5.44e-01	0.157000	6.65e-01
RHOJ GTPase cycle	49	5.82e-02	0.156000	1.27e-01
Signal Transduction	2051	1.90e-31	0.156000	3.65e-29
Vpr-mediated nuclear import of PICs	34	1.16e-01	0.156000	2.17e-01
MAPK family signaling cascades	263	1.41e-05	0.156000	1.30e-04
Chondroitin sulfate biosynthesis	12	3.51e-01	0.155000	4.83e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	3.72e-01	0.155000	5.06e-01
Response to elevated platelet cytosolic Ca2+	109	5.06e-03	0.155000	1.83e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	2.09e-02	0.155000	5.75e-02
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	2.82e-01	0.155000	4.10e-01
G alpha (z) signalling events	36	1.08e-01	0.155000	2.04e-01
ADP signalling through P2Y purinoceptor 12	18	2.55e-01	0.155000	3.84e-01
Signaling by NTRK1 (TRKA)	102	6.90e-03	0.155000	2.35e-02
Aryl hydrocarbon receptor signalling	6	5.12e-01	0.155000	6.37e-01
Transport of small molecules	556	4.84e-10	0.154000	1.08e-08
RIP-mediated NFkB activation via ZBP1	17	2.71e-01	0.154000	3.99e-01
MET receptor recycling	9	4.23e-01	0.154000	5.56e-01
Regulation of FZD by ubiquitination	16	2.86e-01	0.154000	4.13e-01
Defective C1GALT1C1 causes TNPS	10	4.00e-01	-0.154000	5.34e-01
rRNA modification in the nucleus and cytosol	60	3.95e-02	0.154000	9.49e-02
Ion homeostasis	42	8.56e-02	0.153000	1.72e-01
Signaling by Hippo	18	2.61e-01	-0.153000	3.89e-01
Metabolism of water-soluble vitamins and cofactors	116	4.44e-03	0.153000	1.67e-02
Signaling by FGFR2	61	3.89e-02	0.153000	9.43e-02
NEP/NS2 Interacts with the Cellular Export Machinery	32	1.35e-01	0.153000	2.42e-01
Ovarian tumor domain proteases	37	1.08e-01	0.153000	2.05e-01
Negative regulation of MET activity	18	2.64e-01	0.152000	3.93e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	4.30e-01	0.152000	5.63e-01
FGFR2 ligand binding and activation	9	4.30e-01	-0.152000	5.63e-01
SUMOylation of intracellular receptors	26	1.80e-01	0.152000	2.95e-01
Signaling by Interleukins	390	2.65e-07	0.152000	3.57e-06
Termination of O-glycan biosynthesis	16	2.93e-01	0.152000	4.22e-01
RHO GTPases Activate Rhotekin and Rhophilins	8	4.58e-01	0.151000	5.89e-01
Interleukin-6 signaling	11	3.86e-01	0.151000	5.21e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	1.63e-02	0.151000	4.77e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	1.63e-02	0.151000	4.77e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	1.63e-02	0.151000	4.77e-02
CDC6 association with the ORC:origin complex	8	4.61e-01	-0.151000	5.91e-01
PINK1-PRKN Mediated Mitophagy	31	1.48e-01	0.150000	2.57e-01
Processing of SMDT1	15	3.15e-01	0.150000	4.44e-01
CREB3 factors activate genes	6	5.26e-01	0.150000	6.50e-01
Dissolution of Fibrin Clot	12	3.70e-01	-0.150000	5.05e-01
RHO GTPases activate PAKs	20	2.48e-01	0.149000	3.76e-01
Retrograde transport at the Trans-Golgi-Network	49	7.08e-02	0.149000	1.49e-01
TYSND1 cleaves peroxisomal proteins	7	4.94e-01	0.149000	6.21e-01
Gain-of-function MRAS complexes activate RAF signaling	8	4.65e-01	-0.149000	5.93e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	4.65e-01	-0.149000	5.93e-01
Signaling by MRAS-complex mutants	8	4.65e-01	-0.149000	5.93e-01
SUMOylation of ubiquitinylation proteins	39	1.09e-01	0.148000	2.05e-01
Sema4D induced cell migration and growth-cone collapse	19	2.63e-01	0.148000	3.91e-01
Pyroptosis	25	1.99e-01	0.148000	3.19e-01
APC-Cdc20 mediated degradation of Nek2A	26	1.91e-01	0.148000	3.09e-01
Sodium/Proton exchangers	7	4.97e-01	0.148000	6.24e-01
Signaling by ERBB2	44	9.00e-02	0.148000	1.79e-01
Cell recruitment (pro-inflammatory response)	25	2.01e-01	0.148000	3.21e-01
Purinergic signaling in leishmaniasis infection	25	2.01e-01	0.148000	3.21e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	7.70e-02	0.148000	1.59e-01
Synthesis, secretion, and deacylation of Ghrelin	11	3.97e-01	0.147000	5.31e-01
The phototransduction cascade	27	1.88e-01	-0.146000	3.05e-01
RHO GTPase cycle	411	3.69e-07	0.146000	4.81e-06
Post-translational protein phosphorylation	67	3.89e-02	0.146000	9.43e-02
Cell-Cell communication	110	8.23e-03	0.146000	2.75e-02
Defensins	8	4.75e-01	0.146000	6.02e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	2.98e-01	0.146000	4.26e-01
G-protein activation	19	2.72e-01	0.146000	4.01e-01
GAB1 signalosome	14	3.48e-01	0.145000	4.79e-01
Integrin signaling	22	2.40e-01	0.145000	3.68e-01
Bile acid and bile salt metabolism	30	1.70e-01	0.145000	2.83e-01
Formation of the cornified envelope	37	1.28e-01	0.145000	2.32e-01
2-LTR circle formation	7	5.08e-01	0.145000	6.34e-01
Early SARS-CoV-2 Infection Events	32	1.57e-01	0.145000	2.68e-01
Signaling by TGF-beta Receptor Complex	90	1.78e-02	0.145000	5.05e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	3.67e-01	0.144000	5.03e-01
Wax and plasmalogen biosynthesis	5	5.76e-01	-0.144000	6.91e-01
Diseases of mitotic cell cycle	38	1.25e-01	0.144000	2.30e-01
Phosphorylation of the APC/C	20	2.66e-01	0.144000	3.95e-01
Dopamine Neurotransmitter Release Cycle	18	2.92e-01	0.143000	4.22e-01
Transcriptional Regulation by VENTX	39	1.21e-01	0.143000	2.25e-01
Aquaporin-mediated transport	38	1.28e-01	0.143000	2.32e-01
Signaling by NTRKs	116	8.02e-03	0.142000	2.69e-02
Signaling by Receptor Tyrosine Kinases	443	2.77e-07	0.142000	3.68e-06
IL-6-type cytokine receptor ligand interactions	13	3.75e-01	-0.142000	5.09e-01
MITF-M-dependent gene expression	84	2.43e-02	0.142000	6.47e-02
Formation of Incision Complex in GG-NER	43	1.07e-01	0.142000	2.04e-01
Germ layer formation at gastrulation	9	4.61e-01	-0.142000	5.91e-01
LTC4-CYSLTR mediated IL4 production	5	5.82e-01	0.142000	6.97e-01
Mitotic Spindle Checkpoint	108	1.08e-02	0.142000	3.41e-02
Class B/2 (Secretin family receptors)	57	6.45e-02	0.142000	1.38e-01
RUNX1 regulates expression of components of tight junctions	5	5.84e-01	-0.141000	6.98e-01
trans-Golgi Network Vesicle Budding	69	4.23e-02	0.141000	1.01e-01
TGFBR3 expression	20	2.74e-01	0.141000	4.02e-01
Extracellular matrix organization	219	3.14e-04	0.141000	1.76e-03
RAC2 GTPase cycle	85	2.48e-02	0.141000	6.59e-02
TICAM1-dependent activation of IRF3/IRF7	13	3.82e-01	0.140000	5.16e-01
Regulation of TNFR1 signaling	47	9.67e-02	0.140000	1.90e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	5.53e-01	0.140000	6.74e-01
Postmitotic nuclear pore complex (NPC) reformation	27	2.10e-01	0.139000	3.33e-01
RNA polymerase II transcribes snRNA genes	71	4.25e-02	0.139000	1.01e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	1.73e-01	0.139000	2.87e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	4.04e-01	0.139000	5.39e-01
activated TAK1 mediates p38 MAPK activation	23	2.48e-01	0.139000	3.76e-01
Elevation of cytosolic Ca2+ levels	13	3.86e-01	0.139000	5.22e-01
Organelle biogenesis and maintenance	278	7.17e-05	0.138000	5.21e-04
Sphingolipid metabolism	92	2.26e-02	0.138000	6.14e-02
Transport of inorganic cations/anions and amino acids/oligopeptides	79	3.47e-02	0.137000	8.64e-02
Nephron development	5	5.96e-01	0.137000	7.07e-01
Transport of the SLBP independent Mature mRNA	35	1.61e-01	0.137000	2.72e-01
FLT3 signaling in disease	27	2.19e-01	0.137000	3.43e-01
Propionyl-CoA catabolism	5	5.97e-01	0.137000	7.07e-01
Metabolism of non-coding RNA	53	8.51e-02	0.137000	1.72e-01
snRNP Assembly	53	8.51e-02	0.137000	1.72e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	5.33e-01	-0.136000	6.56e-01
Reproduction	86	2.91e-02	0.136000	7.47e-02
RUNX3 Regulates Immune Response and Cell Migration	5	5.99e-01	0.136000	7.08e-01
Reelin signalling pathway	5	5.99e-01	-0.136000	7.08e-01
Signaling by RNF43 mutants	7	5.34e-01	0.136000	6.56e-01
Methionine salvage pathway	6	5.65e-01	0.136000	6.83e-01
Regulation of HSF1-mediated heat shock response	79	3.75e-02	0.135000	9.17e-02
Signaling by NOTCH2	33	1.79e-01	0.135000	2.94e-01
Class I MHC mediated antigen processing & presentation	345	1.62e-05	0.135000	1.48e-04
Antigen processing: Ubiquitination & Proteasome degradation	276	1.15e-04	0.135000	7.56e-04
Abacavir ADME	5	6.02e-01	0.135000	7.10e-01
Beta-oxidation of very long chain fatty acids	11	4.40e-01	0.135000	5.72e-01
Synthesis of bile acids and bile salts	26	2.35e-01	0.135000	3.62e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	1.57e-02	0.135000	4.63e-02
Regulation of CDH11 Expression and Function	22	2.75e-01	0.134000	4.03e-01
TRAF6 mediated NF-kB activation	23	2.65e-01	0.134000	3.94e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	2.06e-01	0.133000	3.28e-01
Processing of Intronless Pre-mRNAs	20	3.02e-01	0.133000	4.29e-01
Regulation of BACH1 activity	11	4.44e-01	0.133000	5.76e-01
Activation of the AP-1 family of transcription factors	10	4.66e-01	-0.133000	5.93e-01
RUNX3 regulates WNT signaling	8	5.15e-01	0.133000	6.40e-01
Vitamin B2 (riboflavin) metabolism	6	5.74e-01	0.133000	6.90e-01
Nuclear Receptor transcription pathway	38	1.57e-01	0.133000	2.68e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	7.35e-02	0.132000	1.54e-01
Signaling by SCF-KIT	40	1.47e-01	0.132000	2.55e-01
Keratinization	38	1.60e-01	0.132000	2.71e-01
Signaling by LTK	10	4.72e-01	0.131000	5.98e-01
mRNA Editing	8	5.20e-01	-0.131000	6.45e-01
Apoptotic factor-mediated response	19	3.22e-01	0.131000	4.52e-01
CLEC7A/inflammasome pathway	6	5.78e-01	0.131000	6.93e-01
Apoptotic cleavage of cellular proteins	35	1.79e-01	0.131000	2.94e-01
VxPx cargo-targeting to cilium	19	3.24e-01	0.131000	4.53e-01
Regulation of TP53 Activity through Phosphorylation	88	3.43e-02	0.131000	8.60e-02
C-type lectin receptors (CLRs)	118	1.47e-02	0.130000	4.33e-02
Ion channel transport	141	7.73e-03	0.130000	2.60e-02
Cytokine Signaling in Immune system	668	1.10e-08	0.130000	1.88e-07
Diseases of hemostasis	14	4.03e-01	0.129000	5.37e-01
Plasma lipoprotein remodeling	18	3.48e-01	0.128000	4.79e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	5.89e-01	0.128000	7.01e-01
Metalloprotease DUBs	20	3.24e-01	0.127000	4.54e-01
Signaling by EGFR	47	1.32e-01	0.127000	2.38e-01
GP1b-IX-V activation signalling	11	4.66e-01	0.127000	5.93e-01
Inactivation of CDC42 and RAC1	7	5.62e-01	-0.127000	6.80e-01
Generic Transcription Pathway	1079	2.33e-12	0.126000	6.60e-11
Reversible hydration of carbon dioxide	8	5.36e-01	0.126000	6.58e-01
NrCAM interactions	6	5.92e-01	0.126000	7.04e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	76	5.70e-02	0.126000	1.25e-01
Metabolism of lipids	641	4.87e-08	0.126000	7.33e-07
Iron uptake and transport	52	1.15e-01	0.126000	2.16e-01
RNA Polymerase II Transcription	1197	1.99e-13	0.126000	6.39e-12
Trafficking and processing of endosomal TLR	13	4.32e-01	0.126000	5.64e-01
CHL1 interactions	8	5.38e-01	-0.126000	6.59e-01
Gene expression (Transcription)	1404	2.67e-15	0.126000	9.52e-14
Synthesis of PIPs at the ER membrane	5	6.26e-01	0.126000	7.30e-01
Chemokine receptors bind chemokines	41	1.63e-01	-0.126000	2.75e-01
RNA Polymerase III Abortive And Retractive Initiation	40	1.69e-01	0.126000	2.81e-01
RNA Polymerase III Transcription	40	1.69e-01	0.126000	2.81e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	1.28e-01	0.126000	2.32e-01
Signaling by TGFB family members	137	1.12e-02	0.126000	3.48e-02
MET activates PTK2 signaling	23	2.97e-01	-0.126000	4.25e-01
Synthesis of diphthamide-EEF2	8	5.42e-01	0.124000	6.64e-01
FOXO-mediated transcription	58	1.02e-01	0.124000	1.97e-01
Assembly of the ORC complex at the origin of replication	23	3.03e-01	0.124000	4.30e-01
SLC-mediated transmembrane transport	174	4.84e-03	0.124000	1.76e-02
Inactivation, recovery and regulation of the phototransduction cascade	26	2.76e-01	-0.123000	4.03e-01
Lysine catabolism	11	4.79e-01	0.123000	6.05e-01
Heme signaling	45	1.53e-01	0.123000	2.64e-01
Mitochondrial unfolded protein response (UPRmt)	17	3.80e-01	0.123000	5.15e-01
Phase 0 - rapid depolarisation	24	2.98e-01	-0.123000	4.25e-01
O-linked glycosylation	85	5.05e-02	0.123000	1.15e-01
Cytochrome P450 - arranged by substrate type	39	1.86e-01	-0.122000	3.03e-01
FGFR1 ligand binding and activation	10	5.04e-01	-0.122000	6.29e-01
Vitamin C (ascorbate) metabolism	8	5.50e-01	0.122000	6.71e-01
Regulation of RUNX1 Expression and Activity	18	3.71e-01	0.122000	5.06e-01
DAP12 signaling	28	2.65e-01	0.122000	3.94e-01
Activation of GABAB receptors	30	2.49e-01	0.122000	3.76e-01
GABA B receptor activation	30	2.49e-01	0.122000	3.76e-01
Gap junction assembly	17	3.87e-01	0.121000	5.22e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	5.08e-01	0.121000	6.34e-01
Signaling by EGFR in Cancer	22	3.27e-01	0.121000	4.56e-01
RHOH GTPase cycle	33	2.31e-01	0.121000	3.57e-01
Aflatoxin activation and detoxification	14	4.37e-01	0.120000	5.69e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	5.34e-01	-0.120000	6.56e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	6.12e-01	-0.120000	7.16e-01
TGFBR1 KD Mutants in Cancer	6	6.12e-01	-0.120000	7.16e-01
ROBO receptors bind AKAP5	7	5.84e-01	0.120000	6.98e-01
Signaling by FGFR1 in disease	32	2.42e-01	-0.119000	3.70e-01
Fatty acid metabolism	157	1.01e-02	0.119000	3.23e-02
Insulin processing	19	3.71e-01	-0.119000	5.05e-01
Uptake of dietary cobalamins into enterocytes	6	6.15e-01	0.119000	7.20e-01
ALK mutants bind TKIs	11	4.96e-01	-0.118000	6.23e-01
Purine catabolism	16	4.14e-01	0.118000	5.47e-01
RND1 GTPase cycle	36	2.22e-01	0.118000	3.48e-01
O-linked glycosylation of mucins	47	1.63e-01	0.118000	2.75e-01
ERBB2 Regulates Cell Motility	10	5.20e-01	0.118000	6.45e-01
G alpha (q) signalling events	139	1.68e-02	0.117000	4.86e-02
TNF signaling	56	1.28e-01	0.117000	2.32e-01
Sensory processing of sound	58	1.23e-01	0.117000	2.27e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	9	5.44e-01	0.117000	6.65e-01
Adherens junctions interactions	38	2.13e-01	0.117000	3.36e-01
HDL remodeling	6	6.21e-01	0.117000	7.25e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	5.94e-01	0.116000	7.06e-01
RAF activation	33	2.48e-01	0.116000	3.76e-01
Assembly of active LPL and LIPC lipase complexes	10	5.25e-01	0.116000	6.49e-01
Small interfering RNA (siRNA) biogenesis	9	5.46e-01	-0.116000	6.67e-01
MITF-M-regulated melanocyte development	113	3.33e-02	0.116000	8.39e-02
M-decay: degradation of maternal mRNAs by maternally stored factors	41	1.99e-01	0.116000	3.19e-01
Interleukin-17 signaling	68	1.00e-01	0.115000	1.94e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	2.60e-01	0.115000	3.88e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	2.60e-01	0.115000	3.88e-01
Endosomal/Vacuolar pathway	12	4.90e-01	-0.115000	6.17e-01
PKR-mediated signaling	67	1.05e-01	0.114000	2.02e-01
Constitutive Signaling by Overexpressed ERBB2	11	5.11e-01	0.114000	6.36e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	1.39e-01	0.114000	2.47e-01
Signaling by Activin	13	4.75e-01	0.114000	6.02e-01
Sensory processing of sound by outer hair cells of the cochlea	41	2.08e-01	0.114000	3.31e-01
Uptake and function of diphtheria toxin	6	6.30e-01	0.114000	7.34e-01
Transcriptional regulation of pluripotent stem cells	19	3.94e-01	-0.113000	5.29e-01
IkBA variant leads to EDA-ID	7	6.05e-01	0.113000	7.13e-01
Regulated Necrosis	56	1.44e-01	0.113000	2.52e-01
TAK1-dependent IKK and NF-kappa-B activation	43	2.01e-01	0.113000	3.21e-01
cGMP effects	12	5.00e-01	-0.113000	6.26e-01
Urea cycle	7	6.07e-01	0.112000	7.14e-01
CD209 (DC-SIGN) signaling	20	3.85e-01	0.112000	5.20e-01
CD28 dependent Vav1 pathway	12	5.01e-01	0.112000	6.27e-01
Integration of provirus	9	5.60e-01	0.112000	6.80e-01
RAC1 GTPase cycle	172	1.15e-02	0.112000	3.58e-02
Growth hormone receptor signaling	20	3.90e-01	0.111000	5.24e-01
Sensory processing of sound by inner hair cells of the cochlea	54	1.58e-01	0.111000	2.69e-01
Glycerophospholipid biosynthesis	105	4.95e-02	0.111000	1.14e-01
Branched-chain amino acid catabolism	21	3.80e-01	0.111000	5.15e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	2.75e-01	0.110000	4.03e-01
Signaling by BRAF and RAF1 fusions	60	1.42e-01	0.110000	2.50e-01
ROS and RNS production in phagocytes	30	3.00e-01	0.109000	4.28e-01
Integration of energy metabolism	88	7.64e-02	0.109000	1.58e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	4.36e-01	0.109000	5.69e-01
SLC transporter disorders	76	1.00e-01	0.109000	1.94e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	6.73e-01	0.109000	7.71e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	6.73e-01	0.109000	7.71e-01
Signaling by MAPK mutants	6	6.45e-01	0.109000	7.47e-01
Biosynthesis of EPA-derived SPMs	6	6.45e-01	0.109000	7.47e-01
ZBP1(DAI) mediated induction of type I IFNs	20	4.02e-01	0.108000	5.36e-01
Anchoring of the basal body to the plasma membrane	97	6.54e-02	0.108000	1.39e-01
RAB geranylgeranylation	63	1.39e-01	0.108000	2.47e-01
Interaction between L1 and Ankyrins	27	3.35e-01	-0.107000	4.65e-01
MET activates RAS signaling	10	5.57e-01	0.107000	6.78e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	1.47e-01	0.107000	2.55e-01
Activation of AMPK downstream of NMDARs	20	4.11e-01	0.106000	5.46e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	6.04e-01	0.106000	7.12e-01
Sensing of DNA Double Strand Breaks	6	6.54e-01	-0.106000	7.55e-01
Digestion	5	6.82e-01	0.106000	7.78e-01
GPCR downstream signalling	399	3.03e-04	0.105000	1.71e-03
HDR through Single Strand Annealing (SSA)	37	2.68e-01	0.105000	3.97e-01
Sensory Perception	194	1.15e-02	-0.105000	3.58e-02
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	1.41e-01	0.105000	2.48e-01
Specification of primordial germ cells	6	6.57e-01	-0.105000	7.58e-01
Phospholipid metabolism	183	1.46e-02	0.105000	4.33e-02
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	4.42e-01	0.105000	5.75e-01
SHC1 events in ERBB4 signaling	10	5.67e-01	-0.105000	6.84e-01
Dermatan sulfate biosynthesis	6	6.59e-01	0.104000	7.59e-01
Metabolism of nitric oxide: NOS3 activation and regulation	14	5.00e-01	0.104000	6.26e-01
Synthesis of UDP-N-acetyl-glucosamine	8	6.11e-01	0.104000	7.16e-01
Na+/Cl- dependent neurotransmitter transporters	8	6.12e-01	-0.104000	7.16e-01
SLBP independent Processing of Histone Pre-mRNAs	10	5.72e-01	0.103000	6.89e-01
Ras activation upon Ca2+ influx through NMDA receptor	18	4.49e-01	-0.103000	5.82e-01
Maturation of nucleoprotein 9683610	11	5.56e-01	0.103000	6.77e-01
O-glycosylation of TSR domain-containing proteins	28	3.48e-01	0.102000	4.79e-01
Signaling by LTK in cancer	7	6.39e-01	0.102000	7.43e-01
Netrin-1 signaling	35	2.96e-01	0.102000	4.24e-01
Defective GALNT12 causes CRCS1	9	5.97e-01	-0.102000	7.08e-01
Miro GTPase Cycle	8	6.19e-01	0.102000	7.23e-01
Amino acid transport across the plasma membrane	25	3.82e-01	0.101000	5.16e-01
Antiviral mechanism by IFN-stimulated genes	140	3.90e-02	0.101000	9.43e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	6.43e-01	0.101000	7.47e-01
RUNX3 regulates CDKN1A transcription	7	6.44e-01	0.101000	7.47e-01
VEGFR2 mediated cell proliferation	18	4.61e-01	0.100000	5.91e-01
PI3K events in ERBB2 signaling	11	5.65e-01	-0.100000	6.82e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	4.50e-01	-0.100000	5.82e-01
Voltage gated Potassium channels	27	3.70e-01	-0.099600	5.05e-01
Diseases associated with O-glycosylation of proteins	50	2.25e-01	0.099300	3.50e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	4.66e-01	0.099200	5.93e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	4.66e-01	0.099200	5.93e-01
Toll Like Receptor 3 (TLR3) Cascade	104	8.08e-02	0.099100	1.65e-01
NS1 Mediated Effects on Host Pathways	40	2.81e-01	0.098500	4.08e-01
Activated NTRK2 signals through FRS2 and FRS3	8	6.31e-01	-0.098200	7.34e-01
Processing and activation of SUMO	10	5.92e-01	0.097900	7.04e-01
Negative regulators of DDX58/IFIH1 signaling	34	3.24e-01	0.097800	4.53e-01
Regulation of CDH19 Expression and Function	6	6.78e-01	0.097800	7.74e-01
Ca2+ activated K+ channels	6	6.78e-01	-0.097800	7.74e-01
Activation of Ca-permeable Kainate Receptor	9	6.12e-01	0.097600	7.16e-01
Ionotropic activity of kainate receptors	9	6.12e-01	0.097600	7.16e-01
Regulation of Expression and Function of Type II Classical Cadherins	24	4.09e-01	0.097300	5.44e-01
Regulation of Homotypic Cell-Cell Adhesion	24	4.09e-01	0.097300	5.44e-01
Diseases of DNA repair	51	2.30e-01	0.097200	3.56e-01
Signaling by GPCR	446	4.34e-04	0.097200	2.31e-03
RAC3 GTPase cycle	87	1.19e-01	0.096700	2.21e-01
MAP kinase activation	63	1.85e-01	0.096600	3.02e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	18	4.79e-01	0.096400	6.04e-01
Nuclear Events (kinase and transcription factor activation)	54	2.21e-01	0.096400	3.45e-01
Negative regulation of FGFR3 signaling	21	4.46e-01	0.096000	5.79e-01
Regulation of FOXO transcriptional activity by acetylation	10	5.99e-01	0.096000	7.08e-01
Cross-presentation of particulate exogenous antigens (phagosomes)	8	6.39e-01	-0.095900	7.43e-01
Toll Like Receptor 4 (TLR4) Cascade	138	5.20e-02	0.095800	1.17e-01
L1CAM interactions	101	9.62e-02	0.095800	1.89e-01
Deadenylation-dependent mRNA decay	50	2.42e-01	0.095700	3.70e-01
Formation of axial mesoderm	6	6.85e-01	-0.095500	7.80e-01
Oncogenic MAPK signaling	76	1.51e-01	0.095300	2.60e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	5.85e-01	0.095000	6.99e-01
RET signaling	32	3.52e-01	0.095000	4.84e-01
PI3K/AKT Signaling in Cancer	84	1.33e-01	0.094900	2.39e-01
Nuclear signaling by ERBB4	24	4.24e-01	0.094300	5.57e-01
Tie2 Signaling	16	5.15e-01	0.093900	6.40e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	1.06e-01	0.093700	2.02e-01
SHC1 events in EGFR signaling	11	5.91e-01	0.093600	7.04e-01
Transferrin endocytosis and recycling	26	4.13e-01	0.092800	5.46e-01
Maturation of nucleoprotein 9694631	15	5.35e-01	0.092500	6.57e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	4.63e-01	0.092500	5.92e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	4.63e-01	0.092500	5.92e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	5.79e-01	0.092400	6.94e-01
Stimuli-sensing channels	80	1.53e-01	0.092300	2.64e-01
MyD88 dependent cascade initiated on endosome	101	1.09e-01	0.092200	2.06e-01
PI Metabolism	79	1.58e-01	0.092000	2.69e-01
MyD88-independent TLR4 cascade	108	9.92e-02	0.091800	1.93e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	9.92e-02	0.091800	1.93e-01
Negative regulation of FGFR4 signaling	22	4.56e-01	0.091800	5.87e-01
Phase 4 - resting membrane potential	9	6.34e-01	0.091700	7.38e-01
Loss of Function of SMAD2/3 in Cancer	7	6.76e-01	-0.091100	7.73e-01
Synthesis of PE	12	5.85e-01	-0.090900	6.99e-01
Regulation of IFNG signaling	14	5.58e-01	-0.090300	6.78e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	4.44e-01	0.090300	5.76e-01
SOS-mediated signalling	7	6.79e-01	-0.090300	7.75e-01
Golgi Associated Vesicle Biogenesis	55	2.47e-01	0.090200	3.75e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	4.21e-01	0.089400	5.54e-01
Apoptotic execution phase	46	2.95e-01	0.089200	4.24e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	5.39e-01	0.088700	6.60e-01
MyD88 cascade initiated on plasma membrane	95	1.39e-01	0.087800	2.47e-01
Toll Like Receptor 10 (TLR10) Cascade	95	1.39e-01	0.087800	2.47e-01
Toll Like Receptor 5 (TLR5) Cascade	95	1.39e-01	0.087800	2.47e-01
Kidney development	17	5.32e-01	-0.087600	6.56e-01
Signaling by FLT3 ITD and TKD mutants	15	5.58e-01	0.087500	6.78e-01
Dectin-2 family	19	5.10e-01	-0.087300	6.36e-01
Cargo trafficking to the periciliary membrane	48	2.96e-01	0.087100	4.24e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	1.23e-01	0.087100	2.27e-01
Glycosphingolipid biosynthesis	15	5.60e-01	0.087000	6.80e-01
Integrin cell surface interactions	65	2.26e-01	0.086800	3.52e-01
MET promotes cell motility	34	3.82e-01	-0.086700	5.16e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	5.26e-01	0.086300	6.50e-01
Insulin receptor recycling	24	4.64e-01	0.086300	5.93e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	5.63e-01	0.086200	6.81e-01
RHO GTPases Activate ROCKs	18	5.29e-01	0.085700	6.53e-01
Metabolism of Angiotensinogen to Angiotensins	12	6.08e-01	0.085400	7.15e-01
Keratan sulfate degradation	9	6.57e-01	0.085400	7.59e-01
Toll Like Receptor 2 (TLR2) Cascade	109	1.28e-01	0.084500	2.32e-01
Toll Like Receptor TLR1:TLR2 Cascade	109	1.28e-01	0.084500	2.32e-01
Synthesis of PIPs at the plasma membrane	52	2.92e-01	0.084500	4.21e-01
Toll-like Receptor Cascades	162	6.37e-02	0.084400	1.37e-01
Fatty acyl-CoA biosynthesis	35	3.88e-01	0.084300	5.23e-01
Cilium Assembly	187	4.69e-02	0.084200	1.09e-01
RIPK1-mediated regulated necrosis	31	4.18e-01	0.084000	5.51e-01
Regulation of necroptotic cell death	31	4.18e-01	0.084000	5.51e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	5.87e-01	0.083800	7.00e-01
Collagen degradation	42	3.48e-01	0.083700	4.79e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	1.33e-01	0.083700	2.39e-01
Toll Like Receptor TLR6:TLR2 Cascade	108	1.33e-01	0.083700	2.39e-01
Negative regulation of FGFR1 signaling	25	4.70e-01	0.083500	5.97e-01
ERBB2 Activates PTK6 Signaling	8	6.83e-01	0.083300	7.78e-01
Uptake and actions of bacterial toxins	27	4.57e-01	0.082800	5.87e-01
Negative regulation of the PI3K/AKT network	91	1.74e-01	0.082500	2.88e-01
Amine ligand-binding receptors	10	6.52e-01	-0.082400	7.54e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	5.82e-01	0.082100	6.97e-01
Interferon Signaling	240	2.92e-02	0.081700	7.49e-02
Triglyceride biosynthesis	9	6.72e-01	-0.081600	7.70e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	4.81e-01	0.081400	6.07e-01
Defective B3GALTL causes PpS	27	4.69e-01	0.080500	5.96e-01
Degradation of the extracellular matrix	96	1.73e-01	0.080400	2.87e-01
Toll Like Receptor 9 (TLR9) Cascade	108	1.49e-01	0.080300	2.58e-01
Lipophagy	7	7.15e-01	0.079700	8.03e-01
Phase II - Conjugation of compounds	70	2.53e-01	0.079000	3.82e-01
Signaling by MET	68	2.63e-01	0.078500	3.91e-01
Protein lipoylation	10	6.69e-01	0.078000	7.68e-01
Triglyceride catabolism	15	6.02e-01	0.077900	7.10e-01
ISG15 antiviral mechanism	72	2.55e-01	0.077600	3.84e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	7.23e-01	0.077500	8.09e-01
Defective GALNT3 causes HFTC	9	6.89e-01	-0.076900	7.82e-01
Nicotinate metabolism	27	4.89e-01	-0.076900	6.16e-01
RNA Polymerase I Transcription Termination	30	4.71e-01	0.076100	5.97e-01
Activation of Matrix Metalloproteinases	22	5.37e-01	0.076100	6.58e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	2.35e-01	0.075000	3.62e-01
Nucleotide catabolism	28	4.97e-01	0.074200	6.23e-01
Neurexins and neuroligins	38	4.30e-01	0.074000	5.63e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	5.99e-01	0.073700	7.08e-01
Visual phototransduction	61	3.31e-01	0.072000	4.61e-01
Apoptosis induced DNA fragmentation	10	6.96e-01	0.071300	7.88e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	6.22e-01	-0.071100	7.26e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	6.58e-01	0.070800	7.59e-01
Downregulation of TGF-beta receptor signaling	26	5.33e-01	0.070600	6.56e-01
Glutamate Neurotransmitter Release Cycle	19	5.97e-01	-0.070100	7.07e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	5.22e-01	0.069800	6.47e-01
Post NMDA receptor activation events	64	3.38e-01	0.069300	4.69e-01
Inwardly rectifying K+ channels	23	5.67e-01	-0.069000	6.84e-01
Phase 2 - plateau phase	11	6.92e-01	-0.069000	7.85e-01
Homologous DNA Pairing and Strand Exchange	43	4.35e-01	0.068900	5.67e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	5.08e-01	0.068800	6.34e-01
TNFR1-induced proapoptotic signaling	24	5.63e-01	0.068100	6.81e-01
Signaling by KIT in disease	20	5.99e-01	0.067900	7.08e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	5.99e-01	0.067900	7.08e-01
Diseases of Mismatch Repair (MMR)	5	7.94e-01	-0.067400	8.65e-01
Transcriptional Regulation by MECP2	49	4.17e-01	0.067100	5.49e-01
Diseases associated with surfactant metabolism	5	7.97e-01	0.066500	8.66e-01
Signaling by PDGF	48	4.27e-01	0.066300	5.60e-01
Sialic acid metabolism	28	5.44e-01	0.066300	6.65e-01
Interleukin-4 and Interleukin-13 signaling	92	2.76e-01	0.065700	4.03e-01
TRIF-mediated programmed cell death	9	7.33e-01	0.065600	8.20e-01
Laminin interactions	26	5.63e-01	-0.065500	6.81e-01
TNFR1-induced NF-kappa-B signaling pathway	32	5.24e-01	0.065000	6.49e-01
Activation of RAC1	11	7.10e-01	0.064800	7.99e-01
Interleukin-10 signaling	39	4.84e-01	-0.064800	6.10e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	6.65e-01	0.064500	7.65e-01
Diseases of branched-chain amino acid catabolism	13	6.91e-01	0.063600	7.84e-01
Deadenylation of mRNA	22	6.07e-01	0.063300	7.14e-01
Cellular hexose transport	15	6.75e-01	0.062500	7.73e-01
Platelet Aggregation (Plug Formation)	29	5.61e-01	0.062400	6.80e-01
eNOS activation	11	7.20e-01	0.062400	8.08e-01
Non-integrin membrane-ECM interactions	49	4.57e-01	-0.061500	5.87e-01
FGFR1b ligand binding and activation	5	8.12e-01	0.061400	8.76e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	6.62e-01	-0.061300	7.62e-01
Sodium/Calcium exchangers	9	7.50e-01	-0.061300	8.33e-01
Nitric oxide stimulates guanylate cyclase	15	6.83e-01	-0.060900	7.78e-01
SLC15A4:TASL-dependent IRF5 activation	6	7.96e-01	0.060900	8.66e-01
DAP12 interactions	39	5.11e-01	0.060800	6.36e-01
Activated NTRK2 signals through RAS	6	7.97e-01	-0.060700	8.66e-01
Activated NTRK3 signals through RAS	6	7.97e-01	-0.060700	8.66e-01
CaMK IV-mediated phosphorylation of CREB	9	7.53e-01	-0.060600	8.35e-01
Transport of nucleotide sugars	9	7.53e-01	0.060500	8.35e-01
RHOBTB2 GTPase cycle	23	6.16e-01	0.060400	7.20e-01
Signaling by NTRK3 (TRKC)	15	6.86e-01	0.060300	7.80e-01
Post-transcriptional silencing by small RNAs	7	7.83e-01	-0.060200	8.56e-01
NOD1/2 Signaling Pathway	36	5.34e-01	0.060000	6.56e-01
P2Y receptors	10	7.43e-01	-0.059900	8.27e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	7.56e-01	0.059800	8.36e-01
FGFR1 mutant receptor activation	25	6.05e-01	-0.059700	7.13e-01
p130Cas linkage to MAPK signaling for integrins	11	7.35e-01	0.059000	8.21e-01
Pyrimidine catabolism	9	7.60e-01	0.058700	8.40e-01
WNT ligand biogenesis and trafficking	20	6.50e-01	-0.058700	7.52e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	6.50e-01	0.058600	7.52e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	7.07e-01	0.058000	7.97e-01
Caspase activation via Death Receptors in the presence of ligand	16	6.88e-01	-0.057900	7.82e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	8.24e-01	-0.057400	8.85e-01
Cell-cell junction organization	57	4.55e-01	0.057200	5.87e-01
MET activates RAP1 and RAC1	10	7.55e-01	-0.056900	8.36e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	7.14e-01	0.056700	8.02e-01
Extra-nuclear estrogen signaling	65	4.31e-01	0.056400	5.64e-01
Defective binding of VWF variant to GPIb:IX:V	6	8.11e-01	-0.056400	8.75e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	6	8.11e-01	-0.056400	8.75e-01
Nephrin family interactions	20	6.63e-01	0.056200	7.63e-01
Synthesis of PC	23	6.42e-01	0.056100	7.45e-01
Protein-protein interactions at synapses	58	4.62e-01	0.055800	5.92e-01
RHOBTB GTPase Cycle	35	5.68e-01	0.055800	6.85e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	7.00e-01	0.055600	7.92e-01
Signaling by Insulin receptor	63	4.50e-01	0.055000	5.82e-01
Biological oxidations	143	2.57e-01	0.054900	3.86e-01
GABA synthesis, release, reuptake and degradation	11	7.53e-01	0.054800	8.35e-01
RHOT1 GTPase cycle	5	8.32e-01	0.054800	8.90e-01
FGFR1c ligand binding and activation	8	7.89e-01	-0.054700	8.61e-01
Potassium Channels	64	4.51e-01	-0.054500	5.82e-01
Impaired BRCA2 binding to RAD51	35	5.80e-01	0.054100	6.94e-01
TRP channels	22	6.62e-01	0.053900	7.62e-01
Signaling by PDGFRA extracellular domain mutants	12	7.48e-01	-0.053600	8.31e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	7.48e-01	-0.053600	8.31e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	7.61e-01	0.053100	8.40e-01
Prolactin receptor signaling	11	7.61e-01	0.052900	8.40e-01
Assembly of collagen fibrils and other multimeric structures	42	5.54e-01	0.052800	6.74e-01
Signaling by FGFR in disease	52	5.10e-01	0.052800	6.36e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	7.52e-01	0.052600	8.35e-01
Acyl chain remodelling of PE	20	6.86e-01	-0.052100	7.80e-01
FOXO-mediated transcription of cell cycle genes	14	7.36e-01	0.052100	8.22e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	7.10e-01	0.052000	7.99e-01
Acyl chain remodelling of PC	19	6.96e-01	-0.051800	7.88e-01
Rap1 signalling	14	7.38e-01	0.051700	8.23e-01
Neurotransmitter receptors and postsynaptic signal transmission	139	2.93e-01	0.051700	4.22e-01
SUMO is proteolytically processed	6	8.27e-01	-0.051600	8.87e-01
Formation of the nephric duct	8	8.01e-01	-0.051300	8.69e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	5.75e-01	0.050600	6.91e-01
Diseases of DNA Double-Strand Break Repair	41	5.75e-01	0.050600	6.91e-01
Signaling by FGFR2 in disease	33	6.17e-01	0.050300	7.21e-01
Signaling by FGFR1	42	5.73e-01	0.050200	6.90e-01
Defects of platelet adhesion to exposed collagen	7	8.18e-01	0.050200	8.80e-01
G alpha (i) signalling events	196	2.36e-01	0.049100	3.63e-01
Signaling by ERBB2 KD Mutants	20	7.06e-01	-0.048800	7.96e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	7.00e-01	0.048600	7.92e-01
IFNG signaling activates MAPKs	8	8.13e-01	-0.048400	8.76e-01
Striated Muscle Contraction	27	6.66e-01	-0.047900	7.65e-01
Phosphate bond hydrolysis by NTPDase proteins	5	8.54e-01	0.047400	9.04e-01
Free fatty acids regulate insulin secretion	10	7.96e-01	0.047200	8.66e-01
Blood group systems biosynthesis	17	7.37e-01	-0.047000	8.23e-01
TRAF6 mediated IRF7 activation	15	7.54e-01	0.046800	8.35e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	7.04e-01	0.046700	7.96e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	8.31e-01	-0.046600	8.90e-01
Myogenesis	20	7.18e-01	0.046600	8.06e-01
Ca2+ pathway	58	5.43e-01	0.046200	6.64e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	7.10e-01	0.045800	7.99e-01
ABC transporters in lipid homeostasis	14	7.70e-01	-0.045100	8.47e-01
Surfactant metabolism	20	7.29e-01	-0.044800	8.16e-01
Muscle contraction	145	3.53e-01	0.044700	4.85e-01
Relaxin receptors	5	8.63e-01	0.044600	9.11e-01
Glucuronidation	8	8.27e-01	-0.044500	8.87e-01
Glycerophospholipid catabolism	7	8.39e-01	0.044300	8.94e-01
Negative regulation of FGFR2 signaling	24	7.07e-01	0.044300	7.97e-01
Activation of caspases through apoptosome-mediated cleavage	6	8.51e-01	-0.044200	9.02e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	6.76e-01	0.044100	7.73e-01
Intrinsic Pathway of Fibrin Clot Formation	15	7.72e-01	-0.043200	8.48e-01
PERK regulates gene expression	31	6.82e-01	-0.042600	7.77e-01
Vitamin D (calciferol) metabolism	11	8.09e-01	0.042200	8.74e-01
RUNX1 regulates estrogen receptor mediated transcription	6	8.59e-01	-0.042000	9.08e-01
Metabolism of steroid hormones	21	7.40e-01	-0.041800	8.25e-01
Syndecan interactions	25	7.24e-01	-0.040700	8.11e-01
Tight junction interactions	17	7.72e-01	-0.040500	8.48e-01
Synthesis of very long-chain fatty acyl-CoAs	22	7.43e-01	-0.040400	8.27e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	7.65e-01	0.038600	8.43e-01
Trafficking of AMPA receptors	20	7.65e-01	0.038600	8.43e-01
Interferon gamma signaling	90	5.27e-01	0.038500	6.51e-01
Calcitonin-like ligand receptors	5	8.82e-01	0.038400	9.22e-01
Signaling by PDGFR in disease	19	7.75e-01	-0.037900	8.48e-01
IRAK1 recruits IKK complex	14	8.07e-01	0.037800	8.73e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	8.07e-01	0.037800	8.73e-01
Activation of NMDA receptors and postsynaptic events	74	5.76e-01	0.037600	6.91e-01
Sensory perception of taste	22	7.61e-01	-0.037500	8.40e-01
Collagen chain trimerization	27	7.36e-01	-0.037400	8.22e-01
Interleukin-6 family signaling	20	7.73e-01	-0.037200	8.48e-01
Defects in cobalamin (B12) metabolism	13	8.18e-01	0.036800	8.80e-01
NCAM signaling for neurite out-growth	47	6.64e-01	0.036600	7.64e-01
Cytochrome c-mediated apoptotic response	13	8.24e-01	0.035600	8.85e-01
Branched-chain ketoacid dehydrogenase kinase deficiency	5	8.90e-01	0.035600	9.26e-01
Recycling of bile acids and salts	10	8.46e-01	0.035500	8.98e-01
Physiological factors	9	8.55e-01	-0.035100	9.05e-01
Metabolic disorders of biological oxidation enzymes	23	7.72e-01	-0.034800	8.48e-01
BBSome-mediated cargo-targeting to cilium	23	7.74e-01	-0.034500	8.48e-01
Scavenging by Class A Receptors	12	8.36e-01	0.034500	8.93e-01
IRAK4 deficiency (TLR2/4)	15	8.17e-01	-0.034400	8.80e-01
Creatine metabolism	6	8.85e-01	-0.034200	9.22e-01
Formation of apoptosome	11	8.46e-01	0.033900	8.98e-01
Regulation of the apoptosome activity	11	8.46e-01	0.033900	8.98e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	7.11e-01	0.033900	8.00e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	7.18e-01	0.033900	8.06e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	8.15e-01	-0.033800	8.78e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	7.70e-01	0.033800	8.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	7.70e-01	0.033800	8.47e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	7.70e-01	0.033800	8.47e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	7.70e-01	0.033800	8.47e-01
Signaling by ERBB2 in Cancer	21	7.91e-01	-0.033400	8.62e-01
Peptide ligand-binding receptors	102	5.62e-01	-0.033300	6.80e-01
Signaling by FGFR3	32	7.45e-01	0.033200	8.29e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	8.43e-01	0.033000	8.98e-01
NCAM1 interactions	26	7.75e-01	-0.032400	8.48e-01
SMAC (DIABLO) binds to IAPs	7	8.82e-01	0.032400	9.22e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	8.82e-01	0.032400	9.22e-01
SMAC, XIAP-regulated apoptotic response	7	8.82e-01	0.032400	9.22e-01
Transmission across Chemical Synapses	183	4.51e-01	0.032300	5.82e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	7.83e-01	-0.031800	8.56e-01
Signaling by NODAL	15	8.32e-01	0.031600	8.90e-01
Neurotoxicity of clostridium toxins	8	8.79e-01	0.031100	9.22e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	7.91e-01	0.030700	8.62e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	7.87e-01	-0.030600	8.60e-01
Signaling by NTRK2 (TRKB)	20	8.14e-01	0.030400	8.77e-01
GRB2 events in ERBB2 signaling	11	8.62e-01	-0.030300	9.10e-01
Serine biosynthesis	8	8.82e-01	0.030200	9.22e-01
Interferon alpha/beta signaling	64	6.77e-01	-0.030100	7.73e-01
GPCR ligand binding	245	4.18e-01	0.030000	5.51e-01
Regulation of beta-cell development	22	8.09e-01	-0.029800	8.74e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	6.97e-01	0.029800	7.88e-01
RAS signaling downstream of NF1 loss-of-function variants	7	8.91e-01	-0.029800	9.26e-01
SHC1 events in ERBB2 signaling	17	8.32e-01	0.029800	8.90e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	8.48e-01	0.029600	8.99e-01
CREB phosphorylation	7	8.92e-01	-0.029600	9.26e-01
Synthesis of PA	31	7.77e-01	-0.029400	8.50e-01
Signaling by ERBB2 ECD mutants	15	8.44e-01	0.029300	8.98e-01
TRAIL signaling	8	8.88e-01	0.028800	9.24e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	8.01e-01	-0.028600	8.69e-01
Estrogen-stimulated signaling through PRKCZ	6	9.04e-01	0.028500	9.36e-01
Sphingolipid catabolism	11	8.71e-01	-0.028400	9.18e-01
Cardiac conduction	89	6.45e-01	0.028200	7.47e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	16	8.47e-01	0.027900	8.98e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	8.35e-01	0.027500	8.93e-01
Histidine catabolism	7	9.00e-01	0.027500	9.33e-01
Cohesin Loading onto Chromatin	10	8.82e-01	0.027000	9.22e-01
Diseases associated with the TLR signaling cascade	29	8.02e-01	0.026900	8.69e-01
Diseases of Immune System	29	8.02e-01	0.026900	8.69e-01
Vitamin B1 (thiamin) metabolism	5	9.17e-01	0.026900	9.45e-01
Activation of G protein gated Potassium channels	19	8.39e-01	0.026900	8.94e-01
G protein gated Potassium channels	19	8.39e-01	0.026900	8.94e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	19	8.39e-01	0.026900	8.94e-01
Loss of Function of TGFBR1 in Cancer	7	9.02e-01	-0.026800	9.35e-01
Gamma-carboxylation of protein precursors	6	9.10e-01	0.026800	9.40e-01
Post-translational modification: synthesis of GPI-anchored proteins	60	7.21e-01	0.026700	8.08e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	18	8.49e-01	0.025900	9.00e-01
CASP8 activity is inhibited	11	8.82e-01	-0.025900	9.22e-01
Dimerization of procaspase-8	11	8.82e-01	-0.025900	9.22e-01
Regulation by c-FLIP	11	8.82e-01	-0.025900	9.22e-01
Signaling by FGFR4	32	8.01e-01	0.025700	8.69e-01
Alpha-protein kinase 1 signaling pathway	11	8.85e-01	-0.025300	9.22e-01
GABA receptor activation	36	7.93e-01	0.025300	8.64e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	8.46e-01	0.025000	8.98e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	8.72e-01	-0.024900	9.19e-01
Formation of Fibrin Clot (Clotting Cascade)	26	8.27e-01	0.024700	8.87e-01
Sperm Motility And Taxes	6	9.18e-01	-0.024200	9.46e-01
Platelet Adhesion to exposed collagen	15	8.73e-01	0.023800	9.20e-01
GRB2 events in EGFR signaling	10	8.99e-01	0.023100	9.33e-01
Cation-coupled Chloride cotransporters	6	9.22e-01	-0.023100	9.48e-01
IRS-mediated signalling	35	8.24e-01	-0.021700	8.85e-01
Neurotransmitter clearance	5	9.34e-01	-0.021300	9.59e-01
Regulation of NPAS4 gene expression	11	9.03e-01	0.021200	9.36e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	8.83e-01	0.020100	9.22e-01
Signaling by cytosolic FGFR1 fusion mutants	18	8.89e-01	0.019000	9.25e-01
Insulin receptor signalling cascade	40	8.36e-01	0.018900	8.93e-01
SHC-related events triggered by IGF1R	7	9.31e-01	0.018800	9.57e-01
Neuronal System	270	5.96e-01	0.018800	7.07e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	8.85e-01	0.018700	9.22e-01
Triglyceride metabolism	24	8.78e-01	0.018100	9.22e-01
Regulation of signaling by NODAL	6	9.41e-01	-0.017500	9.64e-01
Lewis blood group biosynthesis	13	9.14e-01	0.017200	9.44e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	9.16e-01	0.016900	9.45e-01
Xenobiotics	12	9.20e-01	0.016800	9.47e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	37	8.61e-01	0.016600	9.10e-01
Fertilization	13	9.20e-01	-0.016100	9.47e-01
Cobalamin (Cbl) metabolism	7	9.41e-01	-0.016100	9.64e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	9.44e-01	0.015300	9.66e-01
Signaling by ERBB2 TMD/JMD mutants	17	9.13e-01	0.015300	9.43e-01
IGF1R signaling cascade	37	8.79e-01	0.014500	9.22e-01
Transport of RCbl within the body	8	9.44e-01	0.014400	9.66e-01
PI3K Cascade	31	8.91e-01	0.014200	9.26e-01
Signaling by FLT3 fusion proteins	18	9.17e-01	-0.014200	9.45e-01
tRNA modification in the nucleus and cytosol	43	8.73e-01	0.014100	9.20e-01
Impaired BRCA2 binding to PALB2	24	9.06e-01	0.014000	9.37e-01
FGFR2b ligand binding and activation	6	9.54e-01	-0.013600	9.73e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	9.48e-01	-0.013400	9.68e-01
Toxicity of botulinum toxin type D (botD)	5	9.59e-01	0.013100	9.74e-01
Toxicity of botulinum toxin type F (botF)	5	9.59e-01	0.013100	9.74e-01
Intraflagellar transport	47	8.84e-01	0.012300	9.22e-01
Assembly and cell surface presentation of NMDA receptors	34	9.05e-01	0.011800	9.36e-01
Establishment of Sister Chromatid Cohesion	11	9.46e-01	0.011800	9.68e-01
Regulation of TLR by endogenous ligand	15	9.37e-01	0.011800	9.62e-01
Transport of bile salts and organic acids, metal ions and amine compounds	53	8.85e-01	0.011500	9.22e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	9.60e-01	0.011000	9.74e-01
Regulation of insulin secretion	63	8.86e-01	0.010400	9.23e-01
Phase I - Functionalization of compounds	68	8.83e-01	-0.010400	9.22e-01
tRNA modification in the mitochondrion	9	9.58e-01	0.010100	9.74e-01
NGF-stimulated transcription	32	9.22e-01	0.010000	9.48e-01
AMPK inhibits chREBP transcriptional activation activity	6	9.67e-01	0.009650	9.79e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	9.57e-01	0.009330	9.74e-01
Aspirin ADME	15	9.51e-01	0.009160	9.71e-01
Regulation of PTEN localization	9	9.63e-01	0.009030	9.76e-01
NOTCH2 intracellular domain regulates transcription	11	9.60e-01	0.008760	9.74e-01
Regulation of CDH11 mRNA translation by microRNAs	8	9.66e-01	0.008700	9.78e-01
Regulation of NPAS4 mRNA translation	8	9.66e-01	0.008700	9.78e-01
MECP2 regulates neuronal receptors and channels	14	9.55e-01	0.008610	9.74e-01
Incretin synthesis, secretion, and inactivation	14	9.60e-01	0.007710	9.74e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	9.60e-01	0.007710	9.74e-01
Class A/1 (Rhodopsin-like receptors)	177	8.61e-01	0.007630	9.10e-01
Arachidonate metabolism	47	9.30e-01	-0.007440	9.55e-01
IRS-related events triggered by IGF1R	36	9.40e-01	-0.007300	9.64e-01
MyD88 deficiency (TLR2/4)	14	9.62e-01	0.007290	9.76e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	9.64e-01	0.007010	9.76e-01
Anchoring fibril formation	8	9.74e-01	0.006640	9.82e-01
Transcriptional Regulation by NPAS4	27	9.53e-01	0.006540	9.72e-01
Neurotransmitter release cycle	35	9.48e-01	-0.006430	9.68e-01
E2F-enabled inhibition of pre-replication complex formation	9	9.75e-01	0.006090	9.82e-01
Constitutive Signaling by EGFRvIII	14	9.71e-01	-0.005610	9.80e-01
Signaling by EGFRvIII in Cancer	14	9.71e-01	-0.005610	9.80e-01
Regulation of PTEN mRNA translation	13	9.73e-01	0.005390	9.81e-01
Transcriptional regulation of testis differentiation	5	9.83e-01	0.005370	9.88e-01
Long-term potentiation	18	9.69e-01	-0.005340	9.79e-01
Peptide hormone metabolism	53	9.47e-01	-0.005310	9.68e-01
Miscellaneous transport and binding events	20	9.69e-01	-0.004950	9.80e-01
Endogenous sterols	17	9.73e-01	-0.004780	9.81e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	9.87e-01	-0.004220	9.90e-01
NPAS4 regulates expression of target genes	16	9.80e-01	-0.003540	9.87e-01
Nucleotide-like (purinergic) receptors	14	9.83e-01	-0.003280	9.88e-01
RHOBTB1 GTPase cycle	23	9.79e-01	-0.003140	9.86e-01
IKK complex recruitment mediated by RIP1	23	9.83e-01	0.002550	9.88e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	9.92e-01	-0.002440	9.94e-01
Tryptophan catabolism	12	9.88e-01	-0.002420	9.91e-01
Signaling by BMP	23	9.87e-01	-0.001990	9.90e-01
ECM proteoglycans	47	9.82e-01	-0.001930	9.87e-01
Methylation	13	9.91e-01	0.001790	9.93e-01
Defective factor IX causes hemophilia B	6	9.96e-01	0.001140	9.97e-01
Signaling by ERBB4	45	9.93e-01	-0.000757	9.94e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	9.99e-01	0.000485	9.99e-01

---

Detailed Gene set reports

Phosphorylation of Emi1

set	Phosphorylation of Emi1
setSize	6
pANOVA	0.00103
s.dist	0.774
p.adjustANOVA	0.00481

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PLK1	10588
FZR1	10515
CDK1	10505
CDC20	8132
CCNB1	6921
FBXO5	4908

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PLK1	10588
FZR1	10515
CDK1	10505
CDC20	8132
CCNB1	6921
FBXO5	4908

---

Classical antibody-mediated complement activation

set	Classical antibody-mediated complement activation
setSize	70
pANOVA	2.65e-28
s.dist	0.762
p.adjustANOVA	3.93e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
C1R	9624
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
IGKV1-33	7581
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
IGLV2-18	5137
IGHG3	4844
IGLV3-12	1879
IGLC7	1099
IGKV2D-28	957
IGKV2-29	-68
IGHV3-48	-2427
IGHV3-53	-4059
IGLV10-54	-4072
IGKV3-11	-6932
C1S	-8797

---

NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose

set	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
setSize	5
pANOVA	0.00382
s.dist	0.747
p.adjustANOVA	0.0147

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RXRB	10210
NR1H3	8830
RXRA	7749
NR1H2	7719
PLIN1	6998

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RXRB	10210
NR1H3	8830
RXRA	7749
NR1H2	7719
PLIN1	6998

---

Scavenging of heme from plasma

set	Scavenging of heme from plasma
setSize	71
pANOVA	4.36e-27
s.dist	0.739
p.adjustANOVA	5.25e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGHA1	10978
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGHA1	10978
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
JCHAIN	10867
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHA2	10673
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
HBA1	10123
IGHV2-5	9963
IGLV2-23	9780
HBB	9669
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
HP	9472
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
IGKV1-33	7581
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
IGLV2-18	5137
LRP1	4893
IGLV3-12	1879
IGLC7	1099
IGKV2D-28	957
APOL1	702
IGKV2-29	-68
HPX	-865
IGHV3-48	-2427
IGHV3-53	-4059
IGLV10-54	-4072
CD163	-6761
IGKV3-11	-6932

---

Creation of C4 and C2 activators

set	Creation of C4 and C2 activators
setSize	72
pANOVA	3.27e-27
s.dist	0.735
p.adjustANOVA	4.2e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
C1R	9624
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
IGKV1-33	7581
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
IGLV2-18	5137
IGHG3	4844
IGLV3-12	1879
FCN1	1237
IGLC7	1099
IGKV2D-28	957
IGKV2-29	-68
IGHV3-48	-2427
IGHV3-53	-4059
IGLV10-54	-4072
MASP2	-4906
IGKV3-11	-6932
C1S	-8797

---

NR1H2 & NR1H3 regulate gene expression linked to lipogenesis

set	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
setSize	8
pANOVA	0.00046
s.dist	0.715
p.adjustANOVA	0.00244

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FASN	10933
RXRB	10210
SREBF1	9675
NR1H3	8830
SCD	8751
RXRA	7749
NR1H2	7719
NRIP1	-257

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FASN	10933
RXRB	10210
SREBF1	9675
NR1H3	8830
SCD	8751
RXRA	7749
NR1H2	7719
NRIP1	-257

---

Maturation of spike protein_9683686

set	Maturation of spike protein_9683686
setSize	5
pANOVA	0.00577
s.dist	0.713
p.adjustANOVA	0.0204

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GANAB	11033
PRKCSH	9274
MGAT1	8101
MOGS	7265
CANX	3966

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GANAB	11033
PRKCSH	9274
MGAT1	8101
MOGS	7265
CANX	3966

---

Initial triggering of complement

set	Initial triggering of complement
setSize	80
pANOVA	8.7e-27
s.dist	0.692
p.adjustANOVA	9.68e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
C1R	9624
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
GZMM	7728
C4A	7629
IGKV1-33	7581
CFD	7544
CFP	7504
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
IGLV2-18	5137
IGHG3	4844
IGLV3-12	1879
C2	1842
FCN1	1237
IGLC7	1099
IGKV2D-28	957
CFB	711
C3	512
IGKV2-29	-68
IGHV3-48	-2427
IGHV3-53	-4059
IGLV10-54	-4072
MASP2	-4906
C4B	-6355
IGKV3-11	-6932
C1S	-8797

---

FCGR activation

set	FCGR activation
setSize	77
pANOVA	1.59e-25
s.dist	0.687
p.adjustANOVA	1.61e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
HCK	7695
IGKV1-33	7581
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
SRC	5664
FGR	5526
IGLV2-18	5137
FCGR3A	4999
IGHG3	4844
FYN	3741
YES1	2375
SYK	2298
IGLV3-12	1879
IGLC7	1099
IGKV2D-28	957
IGKV2-29	-68
LYN	-590
FCGR1A	-1121
IGHV3-48	-2427
FCGR2A	-3906
IGHV3-53	-4059
IGLV10-54	-4072
IGKV3-11	-6932
CD3G	-7027

---

Synthesis of GDP-mannose

set	Synthesis of GDP-mannose
setSize	6
pANOVA	0.00381
s.dist	0.682
p.adjustANOVA	0.0147

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GMPPB	10337
MPI	9583
HK1	9486
GMPPA	6017
PMM1	5488
PMM2	4636

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GMPPB	10337
MPI	9583
HK1	9486
GMPPA	6017
PMM1	5488
PMM2	4636

---

CD22 mediated BCR regulation

set	CD22 mediated BCR regulation
setSize	59
pANOVA	1.89e-19
s.dist	0.678
p.adjustANOVA	8.66e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
IGHV2-70	9579
PTPN6	9558
IGLV3-19	9482
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGKV1-33	7581
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
IGLC7	1099
IGKV2D-28	957
IGKV2-29	-68
LYN	-590
CD79B	-1947
IGHV3-48	-2427
CD79A	-3765
IGHV3-53	-4059
IGHM	-4721
CD22	-5654
IGHD	-6599
IGKV3-11	-6932

---

Glycosphingolipid transport

set	Glycosphingolipid transport
setSize	7
pANOVA	0.00209
s.dist	0.672
p.adjustANOVA	0.00891

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ESYT1	11013
CPTP	10030
CLN3	8620
ARF1	8135
ESYT2	5886
GLTP	5623
PLEKHA8	3033

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ESYT1	11013
CPTP	10030
CLN3	8620
ARF1	8135
ESYT2	5886
GLTP	5623
PLEKHA8	3033

---

Formation of annular gap junctions

set	Formation of annular gap junctions
setSize	10
pANOVA	0.000251
s.dist	0.669
p.adjustANOVA	0.00144

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DNM2	10814
ACTG1	10481
AP2M1	9216
ACTB	8787
DAB2	8755
CLTA	8261
CLTB	7739
CLTCL1	6762
CLTC	3678
DNM1	-79

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DNM2	10814
ACTG1	10481
AP2M1	9216
ACTB	8787
DAB2	8755
CLTA	8261
CLTB	7739
CLTCL1	6762
CLTC	3678
DNM1	-79

---

Negative regulation of TCF-dependent signaling by DVL-interacting proteins

set	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
setSize	5
pANOVA	0.00993
s.dist	0.666
p.adjustANOVA	0.032

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCDC88C	10004
DVL3	9212
DVL1	8457
DVL2	8407
CXXC4	983

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCDC88C	10004
DVL3	9212
DVL1	8457
DVL2	8407
CXXC4	983

---

Role of LAT2/NTAL/LAB on calcium mobilization

set	Role of LAT2/NTAL/LAB on calcium mobilization
setSize	78
pANOVA	5.74e-23
s.dist	0.646
p.adjustANOVA	3.69e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
PIK3R2	10037
IGHV2-5	9963
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
SHC1	8865
LAT2	8829
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
IGKV1-33	7581
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
IGHE	6485
IGLV2-18	5137
FCER1G	4867
PDPK1	4080
FCER1A	3941
FYN	3741
SYK	2298
IGLV3-12	1879
IGLC7	1099
IGKV2D-28	957
PIK3R1	845
GRB2	530
MS4A2	-48
IGKV2-29	-68
LYN	-590
GAB2	-946
IGHV3-48	-2427
IGHV3-53	-4059
IGLV10-54	-4072
PIK3CB	-4245
PIK3CA	-4578
SOS1	-6486
IGKV3-11	-6932

---

Sulfide oxidation to sulfate

set	Sulfide oxidation to sulfate
setSize	5
pANOVA	0.0126
s.dist	0.645
p.adjustANOVA	0.0386

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ETHE1	10155
TST	8996
SLC25A10	7665
SUOX	6026
TSTD1	3064

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ETHE1	10155
TST	8996
SLC25A10	7665
SUOX	6026
TSTD1	3064

---

Type I hemidesmosome assembly

set	Type I hemidesmosome assembly
setSize	8
pANOVA	0.0016
s.dist	0.644
p.adjustANOVA	0.00714

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRT5	10294
CD151	10022
PLEC	8713
LAMB3	8140
ITGB4	7964
ITGA6	5610
DST	3799
COL17A1	2861

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRT5	10294
CD151	10022
PLEC	8713
LAMB3	8140
ITGB4	7964
ITGA6	5610
DST	3799
COL17A1	2861

---

Diseases of Base Excision Repair

set	Diseases of Base Excision Repair
setSize	5
pANOVA	0.0129
s.dist	0.642
p.adjustANOVA	0.0392

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NEIL1	9190
MUTYH	8714
NTHL1	7215
NEIL3	5471
OGG1	5199

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NEIL1	9190
MUTYH	8714
NTHL1	7215
NEIL3	5471
OGG1	5199

---

NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

set	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
setSize	7
pANOVA	0.00344
s.dist	0.638
p.adjustANOVA	0.0135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RXRB	10210
NCOR2	10147
NR1H3	8830
RXRA	7749
NR1H2	7719
NCOA1	4108
NCOR1	1033

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RXRB	10210
NCOR2	10147
NR1H3	8830
RXRA	7749
NR1H2	7719
NCOA1	4108
NCOR1	1033

---

NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake

set	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
setSize	5
pANOVA	0.0137
s.dist	0.636
p.adjustANOVA	0.0411

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RXRB	10210
NR1H3	8830
RXRA	7749
NR1H2	7719
MYLIP	944

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RXRB	10210
NR1H3	8830
RXRA	7749
NR1H2	7719
MYLIP	944

---

Unwinding of DNA

set	Unwinding of DNA
setSize	12
pANOVA	0.000196
s.dist	0.621
p.adjustANOVA	0.00117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM4	10738
MCM2	10654
CDC45	10178
MCM5	10130
GINS4	9822
MCM6	9759
MCM3	9692
MCM7	9231
GINS2	5192
GINS1	3056
MCM8	-1615
GINS3	-3810

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM4	10738
MCM2	10654
CDC45	10178
MCM5	10130
GINS4	9822
MCM6	9759
MCM3	9692
MCM7	9231
GINS2	5192
GINS1	3056
MCM8	-1615
GINS3	-3810

---

Glyoxylate metabolism and glycine degradation

set	Glyoxylate metabolism and glycine degradation
setSize	13
pANOVA	0.000107
s.dist	0.62
p.adjustANOVA	0.000714

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ALDH4A1	10792
PXMP2	10632
DLST	10506
GRHPR	10429
GLDC	10326
GOT2	9566
OGDH	8007
GNMT	6557
GCSH	6022
AMT	4747
MRPS36	3988
DDO	-42
DLD	-1653

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ALDH4A1	10792
PXMP2	10632
DLST	10506
GRHPR	10429
GLDC	10326
GOT2	9566
OGDH	8007
GNMT	6557
GCSH	6022
AMT	4747
MRPS36	3988
DDO	-42
DLD	-1653

---

Activation of NIMA Kinases NEK9, NEK6, NEK7

set	Activation of NIMA Kinases NEK9, NEK6, NEK7
setSize	7
pANOVA	0.0045
s.dist	0.62
p.adjustANOVA	0.0169

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PLK1	10588
CDK1	10505
CCNB2	9752
NEK9	8131
NEK6	7588
CCNB1	6921
NEK7	-5107

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PLK1	10588
CDK1	10505
CCNB2	9752
NEK9	8131
NEK6	7588
CCNB1	6921
NEK7	-5107

---

G2/M DNA replication checkpoint

set	G2/M DNA replication checkpoint
setSize	5
pANOVA	0.017
s.dist	0.616
p.adjustANOVA	0.049

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PKMYT1	10788
CDK1	10505
CCNB2	9752
CCNB1	6921
WEE1	-3599

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PKMYT1	10788
CDK1	10505
CCNB2	9752
CCNB1	6921
WEE1	-3599

---

Role of phospholipids in phagocytosis

set	Role of phospholipids in phagocytosis
setSize	89
pANOVA	2.15e-23
s.dist	0.61
p.adjustANOVA	1.48e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
PIK3R2	10037
IGHV2-5	9963
PLD4	9883
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
PLA2G6	9526
IGLV3-19	9482
PLD3	9435
IGHG2	9405
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
IGKV1-33	7581
IGKV5-2	7374
ITPR3	7202
IGHV1-69	7094
IGKV2-30	6667
PLCG2	5935
IGLV2-18	5137
FCGR3A	4999
PRKCD	4983
IGHG3	4844
PLD1	3903
AHCYL1	2658
SYK	2298
PLD2	2274
PLCG1	1941
IGLV3-12	1879
IGLC7	1099
IGKV2D-28	957
PIK3R1	845
IGKV2-29	-68
PRKCE	-771
FCGR1A	-1121
IGHV3-48	-2427
FCGR2A	-3906
IGHV3-53	-4059
IGLV10-54	-4072
PIK3CB	-4245
PIK3CA	-4578
ITPR1	-4813
ITPR2	-5385
IGKV3-11	-6932
CD3G	-7027
PLPP5	-7879

---

Binding and Uptake of Ligands by Scavenger Receptors

set	Binding and Uptake of Ligands by Scavenger Receptors
setSize	93
pANOVA	1.6e-23
s.dist	0.599
p.adjustANOVA	1.14e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGHA1	10978
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGHA1	10978
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
JCHAIN	10867
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
HYOU1	10692
IGHA2	10673
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
HBA1	10123
IGHV2-5	9963
IGLV2-23	9780
HBB	9669
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
HP	9472
IGHV3-13	9367
CALR	9363
IGLV3-27	9011
IGHV3-33	8978
SCARB1	8803
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
IGKV1-33	7581
IGKV5-2	7374
SCARA5	7163
IGHV1-69	7094
HSP90B1	6962
IGKV2-30	6667
IGLV2-18	5137
FTL	5015
LRP1	4893
STAB1	4860
STAB2	4819
SCARF1	3918
APOE	3552
HSPH1	3075
SPARC	2807
IGLV3-12	1879
SSC5D	1202
IGLC7	1099
IGKV2D-28	957
APOL1	702
COL1A1	240
IGKV2-29	-68
SCGB3A2	-137
FTH1	-366
HPX	-865
MSR1	-1533
HSP90AA1	-1742
IGHV3-48	-2427
MARCO	-3566
IGHV3-53	-4059
IGLV10-54	-4072
CD36	-6751
CD163	-6761
IGKV3-11	-6932
COLEC12	-9967
COL4A2	-10585

---

Regulation of NFE2L2 gene expression

set	Regulation of NFE2L2 gene expression
setSize	8
pANOVA	0.00368
s.dist	0.593
p.adjustANOVA	0.0143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NOTCH1	10916
RELA	10891
CREBBP	9270
MYC	8977
MAFK	8471
NFKB1	3419
EP300	3087
NFE2L2	-2104

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NOTCH1	10916
RELA	10891
CREBBP	9270
MYC	8977
MAFK	8471
NFKB1	3419
EP300	3087
NFE2L2	-2104

---

Nef Mediated CD4 Down-regulation

set	Nef Mediated CD4 Down-regulation
setSize	9
pANOVA	0.00216
s.dist	0.59
p.adjustANOVA	0.0092

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	9899
AP2A2	9718
AP2M1	9216
ARF1	8135
LCK	5804
AP2S1	5666
CD4	4766
AP2B1	3814
ATP6V1H	2268

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	9899
AP2A2	9718
AP2M1	9216
ARF1	8135
LCK	5804
AP2S1	5666
CD4	4766
AP2B1	3814
ATP6V1H	2268

---

Expression and translocation of olfactory receptors

set	Expression and translocation of olfactory receptors
setSize	52
pANOVA	2.39e-13
s.dist	-0.587
p.adjustANOVA	7.54e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR1D2	-10799
OR2M3	-10788
OR4K17	-10755
OR2AT4	-10737
OR5K2	-10624
OR14J1	-10581
OR2M4	-10576
OR6C75	-10397
OR2G6	-10373
OR7C1	-10203
OR5AS1	-10158
OR10H5	-10077
OR10G3	-10047
OR1I1	-10020
OR2A5	-9790
OR2C3	-9764
OR6Y1	-9693
OR5A1	-9687
OR5AU1	-9677
OR7D2	-9597

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR1D2	-10799
OR2M3	-10788
OR4K17	-10755
OR2AT4	-10737
OR5K2	-10624
OR14J1	-10581
OR2M4	-10576
OR6C75	-10397
OR2G6	-10373
OR7C1	-10203
OR5AS1	-10158
OR10H5	-10077
OR10G3	-10047
OR1I1	-10020
OR2A5	-9790
OR2C3	-9764
OR6Y1	-9693
OR5A1	-9687
OR5AU1	-9677
OR7D2	-9597
OR8A1	-9579
OR4E1	-9460
OR2H2	-9183
OR4D9	-9156
OR2V2	-9081
OR13A1	-8901
OR51L1	-8719
OR10A6	-8507
OR5A2	-8427
OR1M1	-7444
OR2L2	-7380
OR5B2	-7039
OR52N4	-6997
OR4D1	-6769
OR7A17	-6429
OR2A1	-5723
OR2B11	-5673
OR52K1	-5381
EBF1	-5372
OR1A1	-4845
OR10H1	-4581
OR2T33	-2111
OR56A1	-1299
OR5AN1	-122
OR10AC1	-33
OR2I1P	1074
OR10G2	2669
OR6K3	3839
OR2A7	3873
OR2W3	5755
OR6N1	8826
LDB1	10613

---

FCGR3A-mediated IL10 synthesis

set	FCGR3A-mediated IL10 synthesis
setSize	100
pANOVA	5.73e-24
s.dist	0.584
p.adjustANOVA	4.25e-22

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
ADCY3	9807
ADCY7	9801
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
ADCY6	9174
IGLV3-27	9011
IGHV3-33	8978
ADCY9	8949
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
HCK	7695
IGKV1-33	7581
IGKV5-2	7374
ADCY4	7347
ITPR3	7202
IGHV1-69	7094
PRKACA	6943
IGKV2-30	6667
CALM1	6562
PLCG2	5935
SRC	5664
FGR	5526
IGLV2-18	5137
FCGR3A	4999
IGHG3	4844
FYN	3741
PRKAR2A	3531
IL10	3425
PRKAR1A	2709
AHCYL1	2658
YES1	2375
SYK	2298
PLCG1	1941
PRKAR2B	1914
IGLV3-12	1879
PRKX	1488
IGLC7	1099
IGKV2D-28	957
PRKACB	405
IGKV2-29	-68
LYN	-590
PRKAR1B	-622
FCGR1A	-1121
IGHV3-48	-2427
FCGR2A	-3906
IGHV3-53	-4059
IGLV10-54	-4072
ADCY5	-4739
ITPR1	-4813
ITPR2	-5385
ADCY2	-5909
CREB1	-6766
IGKV3-11	-6932
CD3G	-7027

---

Retrograde neurotrophin signalling

set	Retrograde neurotrophin signalling
setSize	12
pANOVA	0.000479
s.dist	0.582
p.adjustANOVA	0.00252

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DNM2	10814
AP2A1	9899
AP2A2	9718
AP2M1	9216
CLTA	8261
DNAL4	8224
NTRK1	6217
AP2S1	5666
AP2B1	3814
CLTC	3678
DNM3	2533
DNM1	-79

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DNM2	10814
AP2A1	9899
AP2A2	9718
AP2M1	9216
CLTA	8261
DNAL4	8224
NTRK1	6217
AP2S1	5666
AP2B1	3814
CLTC	3678
DNM3	2533
DNM1	-79

---

Formation of ATP by chemiosmotic coupling

set	Formation of ATP by chemiosmotic coupling
setSize	20
pANOVA	7.81e-06
s.dist	0.577
p.adjustANOVA	7.77e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5MF	9621
ATP5ME	9587
ATP5F1B	9537
ATP5F1E	9396
ATP5MC2	9377
ATP5PF	9118
MT-ATP6	8545
ATP5MC3	8343
ATP5F1A	8334
ATP5MJ	8138
ATP5PO	7512
ATP5MG	7271
MT-ATP8	6804
ATP5MK	6491
ATP5F1D	5122
ATP5MC1	3420
ATP5PB	3378
ATP5PD	3133
ATP5F1C	2287
DMAC2L	-6590

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5MF	9621
ATP5ME	9587
ATP5F1B	9537
ATP5F1E	9396
ATP5MC2	9377
ATP5PF	9118
MT-ATP6	8545
ATP5MC3	8343
ATP5F1A	8334
ATP5MJ	8138
ATP5PO	7512
ATP5MG	7271
MT-ATP8	6804
ATP5MK	6491
ATP5F1D	5122
ATP5MC1	3420
ATP5PB	3378
ATP5PD	3133
ATP5F1C	2287
DMAC2L	-6590

---

FCERI mediated Ca+2 mobilization

set	FCERI mediated Ca+2 mobilization
setSize	93
pANOVA	1.21e-21
s.dist	0.573
p.adjustANOVA	5.96e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHV3-13	9367
IGLV3-27	9011
IGHV3-33	8978
SHC1	8865
IGHV3-7	8696
IGHV3-30	8472
NFATC3	8223
IGLV4-60	7970
VAV2	7602
IGKV1-33	7581
IGKV5-2	7374
ITPR3	7202
IGHV1-69	7094
NFATC2	6932
NFATC1	6927
IGKV2-30	6667
CALM1	6562
IGHE	6485
LAT	6073
PLCG2	5935
IGLV2-18	5137
FCER1G	4867
FCER1A	3941
LCP2	3172
AHCYL1	2658
GRAP2	2305
SYK	2298
PLCG1	1941
IGLV3-12	1879
TXK	1610
IGLC7	1099
IGKV2D-28	957
GRB2	530
MS4A2	-48
IGKV2-29	-68
LYN	-590
ITK	-1043
TEC	-1194
PPP3CB	-1625
IGHV3-48	-2427
VAV3	-2504
PPP3R1	-2563
PPP3CA	-3781
BTK	-3973
IGHV3-53	-4059
IGLV10-54	-4072
ITPR1	-4813
ITPR2	-5385
SOS1	-6486
IGKV3-11	-6932

---

Synthesis of PG

set	Synthesis of PG
setSize	8
pANOVA	0.00518
s.dist	0.571
p.adjustANOVA	0.0186

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PGS1	10205
PLD4	9883
PLD3	9435
DUSP23	7754
PLD6	5957
PLD1	3903
PLD2	2274
CDS2	1571

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PGS1	10205
PLD4	9883
PLD3	9435
DUSP23	7754
PLD6	5957
PLD1	3903
PLD2	2274
CDS2	1571

---

Regulation of Complement cascade

set	Regulation of Complement cascade
setSize	97
pANOVA	4.35e-22
s.dist	0.567
p.adjustANOVA	2.62e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
CD59	10053
IGHV2-5	9963
IGLV2-23	9780
C1R	9624
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
ELANE	9154
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
CD81	7947
VTN	7936
C4A	7629
IGKV1-33	7581
CFP	7504
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
C8G	5580
IGLV2-18	5137
IGHG3	4844
CD55	4051
C4BPB	2915
CPN2	2534
C5AR2	2290
IGLV3-12	1879
C2	1842
CLU	1398
C5	1101
IGLC7	1099
IGKV2D-28	957
CFB	711
C3	512
CR2	-45
IGKV2-29	-68
CR1	-1190
IGHV3-48	-2427
C3AR1	-2856
PROS1	-3412
C5AR1	-3587
IGHV3-53	-4059
IGLV10-54	-4072
C4BPA	-4552
SERPING1	-5659
C4B	-6355
CD46	-6805
IGKV3-11	-6932
CD19	-7506
C1S	-8797
CFH	-9754

---

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

set	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
setSize	18
pANOVA	3.15e-05
s.dist	0.567
p.adjustANOVA	0.000265

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFDP1	11052
CDK1	10505
E2F4	10276
TFDP2	10156
CARM1	9840
GADD45A	8553
PRMT1	8195
CDC25C	7985
PCNA	7812
TP53	7339
CCNB1	6921
AURKA	5723
BAX	5009
RBL2	4393
EP300	3087
SFN	1588
ZNF385A	961
RBL1	-5548

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFDP1	11052
CDK1	10505
E2F4	10276
TFDP2	10156
CARM1	9840
GADD45A	8553
PRMT1	8195
CDC25C	7985
PCNA	7812
TP53	7339
CCNB1	6921
AURKA	5723
BAX	5009
RBL2	4393
EP300	3087
SFN	1588
ZNF385A	961
RBL1	-5548

---

Nef Mediated CD8 Down-regulation

set	Nef Mediated CD8 Down-regulation
setSize	7
pANOVA	0.00953
s.dist	0.566
p.adjustANOVA	0.0309

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	9899
AP2A2	9718
AP2M1	9216
AP2S1	5666
AP2B1	3814
CD8B	3653
ATP6V1H	2268

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	9899
AP2A2	9718
AP2M1	9216
AP2S1	5666
AP2B1	3814
CD8B	3653
ATP6V1H	2268

---

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

set	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
setSize	9
pANOVA	0.0034
s.dist	0.564
p.adjustANOVA	0.0134

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKT1	10782
ARAP1	9867
UBB	9730
UBA52	7175
DOK1	6776
PTK6	6369
UBC	2556
CBL	1973
RPS27A	1441

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKT1	10782
ARAP1	9867
UBB	9730
UBA52	7175
DOK1	6776
PTK6	6369
UBC	2556
CBL	1973
RPS27A	1441

---

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

set	Beta oxidation of hexanoyl-CoA to butanoyl-CoA
setSize	5
pANOVA	0.0294
s.dist	0.562
p.adjustANOVA	0.0753

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HADHA	8311
HADH	6726
HADHB	6387
ACADS	6122
ECHS1	3870

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HADHA	8311
HADH	6726
HADHB	6387
ACADS	6122
ECHS1	3870

---

VLDLR internalisation and degradation

set	VLDLR internalisation and degradation
setSize	15
pANOVA	0.000171
s.dist	0.56
p.adjustANOVA	0.00105

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	9899
UBB	9730
AP2A2	9718
AP2M1	9216
NR1H3	8830
CLTA	8261
NR1H2	7719
UBA52	7175
AP2S1	5666
VLDLR	5231
AP2B1	3814
CLTC	3678
UBC	2556
RPS27A	1441
MYLIP	944

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	9899
UBB	9730
AP2A2	9718
AP2M1	9216
NR1H3	8830
CLTA	8261
NR1H2	7719
UBA52	7175
AP2S1	5666
VLDLR	5231
AP2B1	3814
CLTC	3678
UBC	2556
RPS27A	1441
MYLIP	944

---

Pausing and recovery of Tat-mediated HIV elongation

set	Pausing and recovery of Tat-mediated HIV elongation
setSize	30
pANOVA	1.37e-07
s.dist	0.556
p.adjustANOVA	1.9e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTDP1	10883
POLR2I	10551
POLR2G	10396
SSRP1	10265
CDK9	10045
NELFCD	9505
POLR2L	9477
POLR2E	9469
POLR2A	9054
POLR2J	8989
NELFB	8546
POLR2C	8443
NELFE	8167
ELOB	8026
SUPT5H	7607
GTF2F1	7239
ELL	6079
SUPT4H1	5807
POLR2F	5742
POLR2D	5649

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTDP1	10883
POLR2I	10551
POLR2G	10396
SSRP1	10265
CDK9	10045
NELFCD	9505
POLR2L	9477
POLR2E	9469
POLR2A	9054
POLR2J	8989
NELFB	8546
POLR2C	8443
NELFE	8167
ELOB	8026
SUPT5H	7607
GTF2F1	7239
ELL	6079
SUPT4H1	5807
POLR2F	5742
POLR2D	5649
POLR2H	5293
POLR2B	4373
NELFA	4354
GTF2F2	2506
SUPT16H	2442
ELOC	1361
ELOA	-226
TCEA1	-516
CCNT1	-564
POLR2K	-2886

---

Tat-mediated HIV elongation arrest and recovery

set	Tat-mediated HIV elongation arrest and recovery
setSize	30
pANOVA	1.37e-07
s.dist	0.556
p.adjustANOVA	1.9e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTDP1	10883
POLR2I	10551
POLR2G	10396
SSRP1	10265
CDK9	10045
NELFCD	9505
POLR2L	9477
POLR2E	9469
POLR2A	9054
POLR2J	8989
NELFB	8546
POLR2C	8443
NELFE	8167
ELOB	8026
SUPT5H	7607
GTF2F1	7239
ELL	6079
SUPT4H1	5807
POLR2F	5742
POLR2D	5649

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTDP1	10883
POLR2I	10551
POLR2G	10396
SSRP1	10265
CDK9	10045
NELFCD	9505
POLR2L	9477
POLR2E	9469
POLR2A	9054
POLR2J	8989
NELFB	8546
POLR2C	8443
NELFE	8167
ELOB	8026
SUPT5H	7607
GTF2F1	7239
ELL	6079
SUPT4H1	5807
POLR2F	5742
POLR2D	5649
POLR2H	5293
POLR2B	4373
NELFA	4354
GTF2F2	2506
SUPT16H	2442
ELOC	1361
ELOA	-226
TCEA1	-516
CCNT1	-564
POLR2K	-2886

---

Complement cascade

set	Complement cascade
setSize	101
pANOVA	5.16e-22
s.dist	0.555
p.adjustANOVA	3.01e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
C1QA	11054
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
C1QB	11039
IGLV3-25	11037
C1QC	11035
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
IGLV1-44	10967
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
IGKV1-5	10567
IGLV2-14	10566
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
IGKC	10180
IGLC3	10157
IGHV3-11	10153
CD59	10053
IGHV2-5	9963
IGLV2-23	9780
C1R	9624
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
ELANE	9154
IGLV3-27	9011
IGHV3-33	8978
IGHV3-7	8696
IGHV3-30	8472
IGLV4-60	7970
CD81	7947
VTN	7936
GZMM	7728
C4A	7629
IGKV1-33	7581
CFD	7544
CFP	7504
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
C8G	5580
IGLV2-18	5137
IGHG3	4844
CD55	4051
C4BPB	2915
CPN2	2534
C5AR2	2290
IGLV3-12	1879
C2	1842
CLU	1398
FCN1	1237
C5	1101
IGLC7	1099
IGKV2D-28	957
CFB	711
C3	512
CR2	-45
IGKV2-29	-68
CR1	-1190
IGHV3-48	-2427
C3AR1	-2856
PROS1	-3412
C5AR1	-3587
IGHV3-53	-4059
IGLV10-54	-4072
C4BPA	-4552
MASP2	-4906
SERPING1	-5659
C4B	-6355
CD46	-6805
IGKV3-11	-6932
CD19	-7506
C1S	-8797
CFH	-9754

---

FCGR3A-mediated phagocytosis

set	FCGR3A-mediated phagocytosis
setSize	122
pANOVA	2.77e-25
s.dist	0.544
p.adjustANOVA	2.43e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
ABL1	11058
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
ABL1	11058
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
MYH9	10604
IGKV1-5	10567
IGLV2-14	10566
ACTG1	10481
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
MYO9B	10223
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
ARPC2	9351
IGLV3-27	9011
IGHV3-33	8978
ACTB	8787
IGHV3-7	8696
IGHV3-30	8472
WAS	8453
ARPC4	8291
NCKIPSD	7996
IGLV4-60	7970
HCK	7695
VAV2	7602
IGKV1-33	7581
ARPC1B	7538
MAPK3	7525
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
BRK1	6509
MYO1C	6367
CYFIP2	5985
WASF2	5830
ELMO1	5720
NCKAP1L	5670
SRC	5664
ARPC1A	5559
FGR	5526
IGLV2-18	5137
FCGR3A	4999
IGHG3	4844
FYN	3741
RAC1	3510
DOCK1	3342
CYFIP1	2794
ELMO2	2389
YES1	2375
SYK	2298
MAPK1	2212
WIPF1	2070
NCK1	1946
IGLV3-12	1879
PTK2	1805
BAIAP2	1433
MYO5A	1118
IGLC7	1099
IGKV2D-28	957
CDC42	587
GRB2	530
IGKV2-29	-68
ACTR3	-192
WASF3	-459
LYN	-590
WASF1	-730
ARPC5	-1038
ARPC3	-1114
WIPF2	-1160
ACTR2	-2108
ABI1	-2159
IGHV3-48	-2427
VAV3	-2504
CRK	-3328
MYO10	-3352
BTK	-3973
IGHV3-53	-4059
IGLV10-54	-4072
ABI2	-5061
WASL	-5452
NCKAP1	-5760
IGKV3-11	-6932
CD3G	-7027

---

Leishmania phagocytosis

set	Leishmania phagocytosis
setSize	122
pANOVA	2.77e-25
s.dist	0.544
p.adjustANOVA	2.43e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
ABL1	11058
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
ABL1	11058
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
MYH9	10604
IGKV1-5	10567
IGLV2-14	10566
ACTG1	10481
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
MYO9B	10223
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
ARPC2	9351
IGLV3-27	9011
IGHV3-33	8978
ACTB	8787
IGHV3-7	8696
IGHV3-30	8472
WAS	8453
ARPC4	8291
NCKIPSD	7996
IGLV4-60	7970
HCK	7695
VAV2	7602
IGKV1-33	7581
ARPC1B	7538
MAPK3	7525
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
BRK1	6509
MYO1C	6367
CYFIP2	5985
WASF2	5830
ELMO1	5720
NCKAP1L	5670
SRC	5664
ARPC1A	5559
FGR	5526
IGLV2-18	5137
FCGR3A	4999
IGHG3	4844
FYN	3741
RAC1	3510
DOCK1	3342
CYFIP1	2794
ELMO2	2389
YES1	2375
SYK	2298
MAPK1	2212
WIPF1	2070
NCK1	1946
IGLV3-12	1879
PTK2	1805
BAIAP2	1433
MYO5A	1118
IGLC7	1099
IGKV2D-28	957
CDC42	587
GRB2	530
IGKV2-29	-68
ACTR3	-192
WASF3	-459
LYN	-590
WASF1	-730
ARPC5	-1038
ARPC3	-1114
WIPF2	-1160
ACTR2	-2108
ABI1	-2159
IGHV3-48	-2427
VAV3	-2504
CRK	-3328
MYO10	-3352
BTK	-3973
IGHV3-53	-4059
IGLV10-54	-4072
ABI2	-5061
WASL	-5452
NCKAP1	-5760
IGKV3-11	-6932
CD3G	-7027

---

Parasite infection

set	Parasite infection
setSize	122
pANOVA	2.77e-25
s.dist	0.544
p.adjustANOVA	2.43e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
ABL1	11058
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV1-12	11069
IGLV1-51	11067
IGLV1-36	11061
ABL1	11058
IGLV3-1	11053
IGLV7-43	11048
IGLC2	11044
IGKV4-1	11042
IGHV4-59	11041
IGLV3-25	11037
IGLV2-11	11032
IGKV3-20	11029
IGHV4-39	11023
IGLC1	10975
CD247	10970
IGLV1-44	10967
VAV1	10952
IGLV3-21	10948
IGHV1-2	10943
IGLV2-8	10939
IGLV1-40	10899
IGHV4-34	10897
IGKV3-15	10886
IGLV6-57	10876
IGLV7-46	10871
IGKV1-17	10868
IGKV2-28	10821
IGHV1-46	10815
IGKV3D-20	10776
IGLV1-47	10753
IGLV8-61	10739
IGKV1D-39	10730
IGHV3-23	10646
IGKV1-16	10616
MYH9	10604
IGKV1-5	10567
IGLV2-14	10566
ACTG1	10481
IGHG4	10385
IGHG1	10373
IGLV4-69	10239
MYO9B	10223
IGKC	10180
IGLC3	10157
IGHV3-11	10153
IGHV2-5	9963
IGLV2-23	9780
IGLV5-45	9614
IGHV2-70	9579
IGLV3-19	9482
IGHG2	9405
IGHV3-13	9367
ARPC2	9351
IGLV3-27	9011
IGHV3-33	8978
ACTB	8787
IGHV3-7	8696
IGHV3-30	8472
WAS	8453
ARPC4	8291
NCKIPSD	7996
IGLV4-60	7970
HCK	7695
VAV2	7602
IGKV1-33	7581
ARPC1B	7538
MAPK3	7525
IGKV5-2	7374
IGHV1-69	7094
IGKV2-30	6667
BRK1	6509
MYO1C	6367
CYFIP2	5985
WASF2	5830
ELMO1	5720
NCKAP1L	5670
SRC	5664
ARPC1A	5559
FGR	5526
IGLV2-18	5137
FCGR3A	4999
IGHG3	4844
FYN	3741
RAC1	3510
DOCK1	3342
CYFIP1	2794
ELMO2	2389
YES1	2375
SYK	2298
MAPK1	2212
WIPF1	2070
NCK1	1946
IGLV3-12	1879
PTK2	1805
BAIAP2	1433
MYO5A	1118
IGLC7	1099
IGKV2D-28	957
CDC42	587
GRB2	530
IGKV2-29	-68
ACTR3	-192
WASF3	-459
LYN	-590
WASF1	-730
ARPC5	-1038
ARPC3	-1114
WIPF2	-1160
ACTR2	-2108
ABI1	-2159
IGHV3-48	-2427
VAV3	-2504
CRK	-3328
MYO10	-3352
BTK	-3973
IGHV3-53	-4059
IGLV10-54	-4072
ABI2	-5061
WASL	-5452
NCKAP1	-5760
IGKV3-11	-6932
CD3G	-7027

---

Abortive elongation of HIV-1 transcript in the absence of Tat

set	Abortive elongation of HIV-1 transcript in the absence of Tat
setSize	23
pANOVA	6.98e-06
s.dist	0.541
p.adjustANOVA	7.08e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTDP1	10883
POLR2I	10551
POLR2G	10396
NELFCD	9505
POLR2L	9477
POLR2E	9469
POLR2A	9054
POLR2J	8989
NELFB	8546
POLR2C	8443
NELFE	8167
SUPT5H	7607
GTF2F1	7239
SUPT4H1	5807
POLR2F	5742
POLR2D	5649
POLR2H	5293
POLR2B	4373
NELFA	4354
GTF2F2	2506

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTDP1	10883
POLR2I	10551
POLR2G	10396
NELFCD	9505
POLR2L	9477
POLR2E	9469
POLR2A	9054
POLR2J	8989
NELFB	8546
POLR2C	8443
NELFE	8167
SUPT5H	7607
GTF2F1	7239
SUPT4H1	5807
POLR2F	5742
POLR2D	5649
POLR2H	5293
POLR2B	4373
NELFA	4354
GTF2F2	2506
POLR2K	-2886
NCBP2	-4699
NCBP1	-5388

---

Gap junction degradation

set	Gap junction degradation
setSize	11
pANOVA	0.00198
s.dist	0.539
p.adjustANOVA	0.00852

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DNM2	10814
ACTG1	10481
AP2M1	9216
ACTB	8787
DAB2	8755
CLTA	8261
CLTB	7739
CLTCL1	6762
CLTC	3678
DNM1	-79
MYO6	-8176

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DNM2	10814
ACTG1	10481
AP2M1	9216
ACTB	8787
DAB2	8755
CLTA	8261
CLTB	7739
CLTCL1	6762
CLTC	3678
DNM1	-79
MYO6	-8176

---

Activation of PUMA and translocation to mitochondria

set	Activation of PUMA and translocation to mitochondria
setSize	9
pANOVA	0.00525
s.dist	0.537
p.adjustANOVA	0.0188

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFDP1	11052
TFDP2	10156
TP73	8456
E2F1	7654
TP53	7339
PPP1R13B	5039
BBC3	4440
TP63	1442
TP53BP2	-1511

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFDP1	11052
TFDP2	10156
TP73	8456
E2F1	7654
TP53	7339
PPP1R13B	5039
BBC3	4440
TP63	1442
TP53BP2	-1511

---

Prevention of phagosomal-lysosomal fusion

set	Prevention of phagosomal-lysosomal fusion
setSize	9
pANOVA	0.00531
s.dist	0.537
p.adjustANOVA	0.019

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBB	9730
CORO1A	9657
HGS	9466
VPS33B	9143
UBA52	7175
RAB7A	7099
UBC	2556
RPS27A	1441
RAB5A	-2268

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBB	9730
CORO1A	9657
HGS	9466
VPS33B	9143
UBA52	7175
RAB7A	7099
UBC	2556
RPS27A	1441
RAB5A	-2268

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report