Mitch Report

date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-1.4506460
A1BG	1.1729523
A1BG-AS1	0.6703085
A1CF	-0.8579185
A2M	-1.0362319
A2M-AS1	-1.0212354

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2725
num_genes_in_profile	21999
duplicated_genes_present	0
num_profile_genes_in_sets	8829
num_profile_genes_not_in_sets	13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1188
num_genesets_included	1537

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
RUNX1 regulates expression of components of tight junctions	5	1.23e-03	-0.834	1.11e-02
APOBEC3G mediated resistance to HIV-1 infection	5	2.84e-03	0.771	2.24e-02
CD163 mediating an anti-inflammatory response	9	7.62e-05	-0.761	1.03e-03
Formation of the ureteric bud	5	3.30e-03	-0.759	2.53e-02
RUNX1 regulates transcription of genes involved in BCR signaling	6	1.46e-03	-0.750	1.28e-02
Phenylalanine metabolism	5	4.32e-03	0.737	3.01e-02
Biosynthesis of Lipoxins (LX)	6	2.53e-03	-0.712	2.02e-02
RUNX3 regulates BCL2L11 (BIM) transcription	5	7.96e-03	-0.685	4.85e-02
POLB-Dependent Long Patch Base Excision Repair	8	9.26e-04	0.676	8.60e-03
Peptide chain elongation	88	8.08e-27	0.660	2.23e-24
Eukaryotic Translation Elongation	93	1.16e-27	0.653	3.75e-25
Formation of a pool of free 40S subunits	100	7.33e-29	0.644	4.72e-26
SARS-CoV-1 modulates host translation machinery	36	2.63e-11	0.642	9.06e-10
Eukaryotic Translation Termination	92	1.93e-26	0.641	4.13e-24
Viral mRNA Translation	88	2.34e-25	0.641	3.48e-23
Selenocysteine synthesis	92	6.81e-26	0.634	1.10e-23
RHOT1 GTPase cycle	5	1.47e-02	-0.630	8.14e-02
TNFR1-mediated ceramide production	6	9.11e-03	0.615	5.47e-02
G2 Phase	5	2.05e-02	-0.598	1.00e-01
Propionyl-CoA catabolism	5	2.15e-02	0.594	1.04e-01
Formation of xylulose-5-phosphate	5	2.15e-02	0.594	1.04e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	4.43e-23	0.590	5.03e-21
NFE2L2 regulates pentose phosphate pathway genes	8	4.06e-03	-0.587	2.88e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.35e-26	0.586	3.25e-24
Translocation of ZAP-70 to Immunological synapse	24	6.89e-07	0.585	1.62e-05
G2/M DNA replication checkpoint	5	2.34e-02	-0.585	1.10e-01
L13a-mediated translational silencing of Ceruloplasmin expression	110	2.86e-26	0.584	5.53e-24
Cap-dependent Translation Initiation	118	5.65e-28	0.584	2.18e-25
Eukaryotic Translation Initiation	118	5.65e-28	0.584	2.18e-25
CD22 mediated BCR regulation	58	2.31e-14	-0.579	1.14e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	3.67e-23	0.573	4.43e-21
Formation of the ternary complex, and subsequently, the 43S complex	51	1.45e-12	0.573	6.08e-11
Scavenging of heme from plasma	70	1.37e-16	-0.571	9.44e-15
Mitochondrial Uncoupling	6	1.62e-02	0.567	8.54e-02
MET activates PI3K/AKT signaling	5	2.82e-02	-0.567	1.26e-01
SARS-CoV-2 modulates host translation machinery	49	7.22e-12	0.566	2.68e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	9.92e-03	-0.563	5.90e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	3.46e-03	-0.563	2.60e-02
Folding of actin by CCT/TriC	10	2.15e-03	0.560	1.74e-02
Defective binding of VWF variant to GPIb:IX:V	7	1.22e-02	-0.547	7.01e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen	7	1.22e-02	-0.547	7.01e-02
SRP-dependent cotranslational protein targeting to membrane	111	3.25e-23	0.545	4.18e-21
Tandem pore domain potassium channels	5	3.55e-02	0.543	1.48e-01
Sperm Motility And Taxes	6	2.20e-02	0.540	1.06e-01
Classical antibody-mediated complement activation	69	1.06e-14	-0.538	5.83e-13
Proton-coupled monocarboxylate transport	6	2.26e-02	-0.538	1.08e-01
Aryl hydrocarbon receptor signalling	6	2.32e-02	0.535	1.10e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	5.47e-05	-0.535	7.71e-04
Inactivation of CDC42 and RAC1	7	1.43e-02	-0.534	7.98e-02
Protein repair	6	2.38e-02	-0.533	1.12e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
RUNX1 regulates expression of components of tight junctions	5	1.23e-03	-0.834000	1.11e-02
APOBEC3G mediated resistance to HIV-1 infection	5	2.84e-03	0.771000	2.24e-02
CD163 mediating an anti-inflammatory response	9	7.62e-05	-0.761000	1.03e-03
Formation of the ureteric bud	5	3.30e-03	-0.759000	2.53e-02
RUNX1 regulates transcription of genes involved in BCR signaling	6	1.46e-03	-0.750000	1.28e-02
Phenylalanine metabolism	5	4.32e-03	0.737000	3.01e-02
Biosynthesis of Lipoxins (LX)	6	2.53e-03	-0.712000	2.02e-02
RUNX3 regulates BCL2L11 (BIM) transcription	5	7.96e-03	-0.685000	4.85e-02
POLB-Dependent Long Patch Base Excision Repair	8	9.26e-04	0.676000	8.60e-03
Peptide chain elongation	88	8.08e-27	0.660000	2.23e-24
Eukaryotic Translation Elongation	93	1.16e-27	0.653000	3.75e-25
Formation of a pool of free 40S subunits	100	7.33e-29	0.644000	4.72e-26
SARS-CoV-1 modulates host translation machinery	36	2.63e-11	0.642000	9.06e-10
Eukaryotic Translation Termination	92	1.93e-26	0.641000	4.13e-24
Viral mRNA Translation	88	2.34e-25	0.641000	3.48e-23
Selenocysteine synthesis	92	6.81e-26	0.634000	1.10e-23
RHOT1 GTPase cycle	5	1.47e-02	-0.630000	8.14e-02
TNFR1-mediated ceramide production	6	9.11e-03	0.615000	5.47e-02
G2 Phase	5	2.05e-02	-0.598000	1.00e-01
Propionyl-CoA catabolism	5	2.15e-02	0.594000	1.04e-01
Formation of xylulose-5-phosphate	5	2.15e-02	0.594000	1.04e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	4.43e-23	0.590000	5.03e-21
NFE2L2 regulates pentose phosphate pathway genes	8	4.06e-03	-0.587000	2.88e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.35e-26	0.586000	3.25e-24
Translocation of ZAP-70 to Immunological synapse	24	6.89e-07	0.585000	1.62e-05
G2/M DNA replication checkpoint	5	2.34e-02	-0.585000	1.10e-01
L13a-mediated translational silencing of Ceruloplasmin expression	110	2.86e-26	0.584000	5.53e-24
Cap-dependent Translation Initiation	118	5.65e-28	0.584000	2.18e-25
Eukaryotic Translation Initiation	118	5.65e-28	0.584000	2.18e-25
CD22 mediated BCR regulation	58	2.31e-14	-0.579000	1.14e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	3.67e-23	0.573000	4.43e-21
Formation of the ternary complex, and subsequently, the 43S complex	51	1.45e-12	0.573000	6.08e-11
Scavenging of heme from plasma	70	1.37e-16	-0.571000	9.44e-15
Mitochondrial Uncoupling	6	1.62e-02	0.567000	8.54e-02
MET activates PI3K/AKT signaling	5	2.82e-02	-0.567000	1.26e-01
SARS-CoV-2 modulates host translation machinery	49	7.22e-12	0.566000	2.68e-10
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	9.92e-03	-0.563000	5.90e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	3.46e-03	-0.563000	2.60e-02
Folding of actin by CCT/TriC	10	2.15e-03	0.560000	1.74e-02
Defective binding of VWF variant to GPIb:IX:V	7	1.22e-02	-0.547000	7.01e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen	7	1.22e-02	-0.547000	7.01e-02
SRP-dependent cotranslational protein targeting to membrane	111	3.25e-23	0.545000	4.18e-21
Tandem pore domain potassium channels	5	3.55e-02	0.543000	1.48e-01
Sperm Motility And Taxes	6	2.20e-02	0.540000	1.06e-01
Classical antibody-mediated complement activation	69	1.06e-14	-0.538000	5.83e-13
Proton-coupled monocarboxylate transport	6	2.26e-02	-0.538000	1.08e-01
Aryl hydrocarbon receptor signalling	6	2.32e-02	0.535000	1.10e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	5.47e-05	-0.535000	7.71e-04
Inactivation of CDC42 and RAC1	7	1.43e-02	-0.534000	7.98e-02
Protein repair	6	2.38e-02	-0.533000	1.12e-01
Selenoamino acid metabolism	115	9.80e-23	0.529000	1.05e-20
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.74e-22	0.528000	1.68e-20
Nonsense-Mediated Decay (NMD)	114	1.74e-22	0.528000	1.68e-20
FBXW7 Mutants and NOTCH1 in Cancer	5	4.45e-02	0.519000	1.73e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	4.45e-02	0.519000	1.73e-01
Regulation of FOXO transcriptional activity by acetylation	10	4.58e-03	-0.518000	3.17e-02
Replacement of protamines by nucleosomes in the male pronucleus	13	1.26e-03	-0.517000	1.12e-02
Signal attenuation	9	7.54e-03	-0.514000	4.67e-02
Creation of C4 and C2 activators	71	1.03e-13	-0.510000	4.50e-12
MET activates RAP1 and RAC1	10	5.31e-03	-0.509000	3.60e-02
Role of LAT2/NTAL/LAB on calcium mobilization	77	1.66e-14	-0.506000	8.67e-13
PD-1 signaling	28	3.82e-06	0.504000	7.37e-05
ARMS-mediated activation	6	3.27e-02	-0.504000	1.39e-01
PI3K/AKT activation	8	1.37e-02	-0.503000	7.71e-02
Miro GTPase Cycle	8	1.38e-02	-0.503000	7.74e-02
Prostanoid ligand receptors	8	1.39e-02	-0.502000	7.80e-02
Regulation of expression of SLITs and ROBOs	149	4.14e-26	0.501000	7.28e-24
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	3.37e-02	-0.501000	1.42e-01
Common Pathway of Fibrin Clot Formation	13	1.81e-03	-0.500000	1.53e-02
Translation initiation complex formation	58	5.71e-11	0.497000	1.87e-09
Influenza Viral RNA Transcription and Replication	135	1.96e-23	0.497000	2.70e-21
Ribosomal scanning and start codon recognition	58	5.94e-11	0.497000	1.91e-09
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	4.53e-11	0.495000	1.51e-09
Prolonged ERK activation events	13	1.99e-03	-0.495000	1.64e-02
FCGR activation	76	8.91e-14	-0.494000	4.20e-12
Anchoring fibril formation	10	7.14e-03	-0.491000	4.48e-02
Estrogen biosynthesis	5	5.84e-02	-0.489000	2.04e-01
Vpu mediated degradation of CD4	39	1.81e-07	0.483000	4.41e-06
Acetylcholine Neurotransmitter Release Cycle	11	5.71e-03	0.481000	3.81e-02
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	2.84e-02	0.478000	1.26e-01
Phosphorylation of CD3 and TCR zeta chains	27	1.81e-05	0.477000	2.89e-04
Coenzyme A biosynthesis	7	2.93e-02	0.476000	1.27e-01
Mitochondrial translation initiation	90	5.98e-15	0.476000	3.40e-13
Chromatin modifications during the maternal to zygotic transition (MZT)	23	8.48e-05	-0.473000	1.11e-03
Frs2-mediated activation	11	6.66e-03	-0.472000	4.23e-02
Regulation of Complement cascade	96	1.28e-15	-0.472000	7.98e-14
Translation	293	1.03e-43	0.470000	1.99e-40
Mitochondrial translation elongation	90	1.35e-14	0.469000	7.24e-13
Mitochondrial translation	96	2.68e-15	0.467000	1.57e-13
Mitochondrial translation termination	90	2.26e-14	0.465000	1.14e-12
CYP2E1 reactions	6	4.86e-02	0.465000	1.81e-01
TICAM1-dependent activation of IRF3/IRF7	13	3.87e-03	0.463000	2.78e-02
Autodegradation of the E3 ubiquitin ligase COP1	38	8.15e-07	0.462000	1.85e-05
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	7.00e-05	0.459000	9.61e-04
NFE2L2 regulating tumorigenic genes	11	8.41e-03	-0.459000	5.08e-02
2-LTR circle formation	7	3.57e-02	0.458000	1.49e-01
Proteasome assembly	50	2.31e-08	0.457000	6.12e-07
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	1.25e-02	-0.456000	7.09e-02
Recycling of eIF2:GDP	8	2.56e-02	0.456000	1.17e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	3.78e-02	0.453000	1.56e-01
Cytosolic tRNA aminoacylation	24	1.27e-04	0.452000	1.57e-03
NIK–>noncanonical NF-kB signaling	46	1.17e-07	0.451000	2.97e-06
Cross-presentation of soluble exogenous antigens (endosomes)	35	3.91e-06	0.451000	7.40e-05
BBSome-mediated cargo-targeting to cilium	22	2.54e-04	0.450000	2.85e-03
Influenza Infection	154	5.59e-22	0.449000	5.14e-20
MET receptor recycling	9	2.00e-02	-0.448000	9.86e-02
HSF1 activation	26	8.00e-05	0.447000	1.06e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	5.48e-04	-0.446000	5.45e-03
RHOT2 GTPase cycle	7	4.10e-02	-0.446000	1.64e-01
OAS antiviral response	8	2.91e-02	0.446000	1.27e-01
PCNA-Dependent Long Patch Base Excision Repair	21	4.19e-04	0.445000	4.40e-03
Initial triggering of complement	79	9.06e-12	-0.444000	3.30e-10
Inhibition of Signaling by Overexpressed EGFR	6	6.00e-02	-0.443000	2.06e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	6	6.00e-02	-0.443000	2.06e-01
Butyrophilin (BTN) family interactions	9	2.13e-02	0.443000	1.04e-01
Defective factor IX causes hemophilia B	6	6.02e-02	-0.443000	2.06e-01
Ubiquitin-dependent degradation of Cyclin D	39	1.71e-06	0.443000	3.64e-05
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	8.06e-03	-0.442000	4.89e-02
Dermatan sulfate biosynthesis	6	6.16e-02	-0.441000	2.08e-01
Defects of platelet adhesion to exposed collagen	8	3.12e-02	-0.440000	1.35e-01
Interleukin-21 signaling	9	2.24e-02	0.440000	1.07e-01
Regulation of CDH19 Expression and Function	6	6.24e-02	0.439000	2.09e-01
Dectin-1 mediated noncanonical NF-kB signaling	48	1.39e-07	0.439000	3.45e-06
Digestion and absorption	7	4.49e-02	-0.438000	1.73e-01
MECP2 regulates transcription of neuronal ligands	5	9.02e-02	0.438000	2.69e-01
Scavenging by Class F Receptors	5	9.19e-02	0.435000	2.72e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	1.21e-06	0.433000	2.65e-05
tRNA processing in the mitochondrion	24	2.58e-04	-0.431000	2.88e-03
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	9.56e-02	0.430000	2.79e-01
SCF-beta-TrCP mediated degradation of Emi1	42	1.50e-06	0.429000	3.22e-05
Digestion	5	9.71e-02	-0.428000	2.81e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	2.11e-06	0.428000	4.30e-05
Complement cascade	100	1.46e-13	-0.427000	6.27e-12
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	6.84e-06	0.427000	1.20e-04
Purine salvage	12	1.07e-02	0.426000	6.29e-02
Keratan sulfate degradation	9	2.72e-02	-0.425000	1.22e-01
Generation of second messenger molecules	38	6.33e-06	0.423000	1.13e-04
Vif-mediated degradation of APOBEC3G	41	2.74e-06	0.423000	5.46e-05
Erythrocytes take up carbon dioxide and release oxygen	11	1.52e-02	-0.423000	8.20e-02
O2/CO2 exchange in erythrocytes	11	1.52e-02	-0.423000	8.20e-02
Integration of provirus	9	2.90e-02	0.420000	1.27e-01
Interferon alpha/beta signaling	64	6.48e-09	0.419000	1.76e-07
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	2.71e-06	0.418000	5.45e-05
Chondroitin sulfate biosynthesis	12	1.24e-02	-0.417000	7.09e-02
ChREBP activates metabolic gene expression	7	5.68e-02	-0.416000	2.00e-01
Role of phospholipids in phagocytosis	88	1.68e-11	-0.415000	6.02e-10
Negative regulation of NOTCH4 signaling	44	2.02e-06	0.414000	4.15e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	7.88e-06	0.413000	1.35e-04
p53-Independent DNA Damage Response	39	7.88e-06	0.413000	1.35e-04
p53-Independent G1/S DNA damage checkpoint	39	7.88e-06	0.413000	1.35e-04
PTK6 Regulates Cell Cycle	6	7.98e-02	0.413000	2.51e-01
Leading Strand Synthesis	14	7.47e-03	0.413000	4.64e-02
Polymerase switching	14	7.47e-03	0.413000	4.64e-02
Early Phase of HIV Life Cycle	14	7.67e-03	0.412000	4.72e-02
Glucuronidation	9	3.30e-02	-0.410000	1.40e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	83	1.18e-10	-0.409000	3.69e-09
RNA Polymerase I Promoter Opening	17	3.53e-03	-0.409000	2.62e-02
Neurotransmitter clearance	6	8.31e-02	-0.409000	2.57e-01
Diseases of hemostasis	15	6.26e-03	-0.408000	4.05e-02
Physiological factors	9	3.42e-02	-0.408000	1.44e-01
Nucleotide biosynthesis	12	1.49e-02	0.406000	8.16e-02
Formation of the active cofactor, UDP-glucuronate	5	1.16e-01	-0.406000	3.18e-01
FCGR3A-mediated IL10 synthesis	99	3.47e-12	-0.404000	1.31e-10
Synthesis of PIPs at the late endosome membrane	11	2.04e-02	-0.404000	1.00e-01
Organic cation transport	8	4.90e-02	-0.402000	1.81e-01
Organic cation/anion/zwitterion transport	8	4.90e-02	-0.402000	1.81e-01
Creatine metabolism	6	8.87e-02	0.401000	2.66e-01
Methionine salvage pathway	6	8.88e-02	0.401000	2.66e-01
Major pathway of rRNA processing in the nucleolus and cytosol	179	2.11e-20	0.401000	1.63e-18
Stabilization of p53	43	5.45e-06	0.401000	9.93e-05
Binding and Uptake of Ligands by Scavenger Receptors	94	1.99e-11	-0.400000	6.98e-10
Erythrocytes take up oxygen and release carbon dioxide	7	6.73e-02	-0.399000	2.22e-01
Mitochondrial RNA degradation	25	5.57e-04	-0.399000	5.52e-03
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.24e-01	0.398000	3.32e-01
Neurofascin interactions	5	1.24e-01	-0.397000	3.32e-01
Vitamin B2 (riboflavin) metabolism	6	9.29e-02	0.396000	2.73e-01
rRNA processing in the nucleus and cytosol	189	7.83e-21	0.394000	6.88e-19
FCERI mediated Ca+2 mobilization	92	6.47e-11	-0.394000	2.05e-09
Processing of SMDT1	15	8.55e-03	0.392000	5.14e-02
Degradation of AXIN	42	1.11e-05	0.392000	1.87e-04
Regulation of Apoptosis	40	1.81e-05	0.392000	2.89e-04
Antimicrobial peptides	34	7.74e-05	-0.392000	1.03e-03
Release of apoptotic factors from the mitochondria	6	9.67e-02	0.392000	2.80e-01
Attenuation phase	23	1.15e-03	0.391000	1.06e-02
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	4.08e-03	0.391000	2.89e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	1.48e-02	-0.390000	8.14e-02
GABA synthesis, release, reuptake and degradation	12	1.93e-02	0.390000	9.64e-02
Resolution of Abasic Sites (AP sites)	38	3.35e-05	0.389000	5.06e-04
LTC4-CYSLTR mediated IL4 production	5	1.32e-01	0.389000	3.42e-01
Degradation of DVL	43	1.08e-05	0.388000	1.83e-04
CDH11 homotypic and heterotypic interactions	6	1.01e-01	0.387000	2.89e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	8.58e-04	0.385000	8.13e-03
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	2.74e-02	0.384000	1.23e-01
Assembly of active LPL and LIPC lipase complexes	10	3.60e-02	-0.383000	1.49e-01
RSK activation	7	7.97e-02	-0.382000	2.51e-01
Cellular response to starvation	148	2.17e-15	0.377000	1.31e-13
DNA methylation	18	5.68e-03	-0.377000	3.81e-02
Uptake of dietary cobalamins into enterocytes	6	1.10e-01	0.376000	3.09e-01
FCERI mediated MAPK activation	93	3.52e-10	-0.376000	1.05e-08
Estrogen-stimulated signaling through PRKCZ	6	1.11e-01	-0.376000	3.09e-01
Autodegradation of Cdh1 by Cdh1:APC/C	54	1.76e-06	0.376000	3.70e-05
Synthesis of 5-eicosatetraenoic acids	7	8.51e-02	-0.376000	2.61e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	1.50e-02	0.375000	8.20e-02
mRNA Splicing - Major Pathway	203	2.83e-20	0.375000	2.10e-18
Trafficking and processing of endosomal TLR	13	1.92e-02	0.375000	9.64e-02
Anti-inflammatory response favouring Leishmania parasite infection	132	9.90e-14	-0.375000	4.45e-12
Leishmania parasite growth and survival	132	9.90e-14	-0.375000	4.45e-12
tRNA Aminoacylation	42	2.64e-05	0.375000	4.08e-04
Reelin signalling pathway	5	1.47e-01	-0.374000	3.64e-01
Degradation of GLI2 by the proteasome	45	1.43e-05	0.374000	2.37e-04
NFE2L2 regulating MDR associated enzymes	8	6.73e-02	-0.374000	2.22e-01
mRNA Splicing	211	8.74e-21	0.373000	7.34e-19
Signaling by ROBO receptors	189	9.57e-19	0.373000	6.85e-17
FCGR3A-mediated phagocytosis	121	1.64e-12	-0.371000	6.48e-11
Leishmania phagocytosis	121	1.64e-12	-0.371000	6.48e-11
Parasite infection	121	1.64e-12	-0.371000	6.48e-11
PI-3K cascade:FGFR1	13	2.04e-02	-0.371000	1.00e-01
Malate-aspartate shuttle	8	7.04e-02	0.369000	2.29e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.53e-01	0.369000	3.74e-01
mRNA Splicing - Minor Pathway	50	6.40e-06	0.369000	1.13e-04
Hh mutants are degraded by ERAD	42	3.53e-05	0.369000	5.28e-04
Formation of Fibrin Clot (Clotting Cascade)	26	1.17e-03	-0.368000	1.07e-02
SLBP independent Processing of Histone Pre-mRNAs	10	4.42e-02	0.367000	1.73e-01
GLI3 is processed to GLI3R by the proteasome	46	1.63e-05	0.367000	2.67e-04
Carnitine shuttle	12	2.83e-02	0.366000	1.26e-01
Somitogenesis	41	5.39e-05	0.364000	7.66e-04
Signaling by NODAL	15	1.48e-02	-0.363000	8.14e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.71e-02	0.363000	1.53e-01
Protein lipoylation	10	4.70e-02	0.363000	1.78e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	1.60e-01	0.363000	3.82e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	1.61e-01	0.362000	3.82e-01
Translesion synthesis by REV1	16	1.23e-02	0.361000	7.05e-02
Interleukin-18 signaling	6	1.26e-01	-0.361000	3.35e-01
Suppression of apoptosis	7	9.91e-02	-0.360000	2.86e-01
APC/C:Cdc20 mediated degradation of Securin	55	3.89e-06	0.360000	7.40e-05
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.99e-02	0.359000	9.85e-02
Regulation of ornithine decarboxylase (ODC)	38	1.37e-04	0.357000	1.68e-03
Platelet Adhesion to exposed collagen	16	1.35e-02	-0.357000	7.61e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	1.30e-01	0.357000	3.42e-01
Uptake and function of diphtheria toxin	6	1.30e-01	0.357000	3.42e-01
Lagging Strand Synthesis	20	5.83e-03	0.356000	3.88e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	4.10e-02	0.356000	1.64e-01
Polymerase switching on the C-strand of the telomere	26	1.73e-03	0.355000	1.47e-02
Cytosolic iron-sulfur cluster assembly	13	2.70e-02	0.354000	1.22e-01
Apoptotic cleavage of cell adhesion proteins	8	8.29e-02	-0.354000	2.57e-01
Synthesis of diphthamide-EEF2	8	8.34e-02	0.353000	2.57e-01
Hh mutants abrogate ligand secretion	43	6.34e-05	0.352000	8.82e-04
RUNX3 regulates p14-ARF	10	5.38e-02	-0.352000	1.92e-01
Response to metal ions	6	1.35e-01	-0.352000	3.47e-01
AMPK inhibits chREBP transcriptional activation activity	6	1.36e-01	-0.352000	3.48e-01
SCF(Skp2)-mediated degradation of p27/p21	50	1.71e-05	0.351000	2.78e-04
GAB1 signalosome	15	1.87e-02	-0.351000	9.44e-02
Processive synthesis on the lagging strand	15	1.94e-02	0.349000	9.66e-02
Degradation of GLI1 by the proteasome	46	4.31e-05	0.349000	6.35e-04
Glycerophospholipid catabolism	6	1.40e-01	0.348000	3.54e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	6	1.41e-01	-0.347000	3.56e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	1.14e-01	-0.345000	3.16e-01
Other semaphorin interactions	16	1.69e-02	-0.345000	8.78e-02
Complex I biogenesis	66	1.29e-06	0.344000	2.80e-05
Crosslinking of collagen fibrils	15	2.17e-02	-0.342000	1.04e-01
Amyloid fiber formation	52	1.94e-05	-0.342000	3.04e-04
Role of ABL in ROBO-SLIT signaling	6	1.47e-01	-0.342000	3.64e-01
Transcriptional regulation of granulopoiesis	44	8.89e-05	-0.341000	1.14e-03
Mitochondrial unfolded protein response (UPRmt)	17	1.48e-02	0.341000	8.14e-02
PI-3K cascade:FGFR3	10	6.19e-02	-0.341000	2.08e-01
Transport of RCbl within the body	8	9.51e-02	-0.341000	2.78e-01
HSF1-dependent transactivation	30	1.25e-03	0.340000	1.11e-02
Purine ribonucleoside monophosphate biosynthesis	9	7.79e-02	0.339000	2.46e-01
RHO GTPases activate PKNs	46	7.31e-05	-0.338000	9.94e-04
RHOJ GTPase cycle	50	3.66e-05	-0.337000	5.44e-04
Phenylalanine and tyrosine metabolism	9	8.07e-02	0.336000	2.53e-01
Synthesis, secretion, and deacylation of Ghrelin	11	5.39e-02	0.336000	1.92e-01
Regulation of actin dynamics for phagocytic cup formation	123	1.38e-10	-0.335000	4.22e-09
N-glycan antennae elongation in the medial/trans-Golgi	21	7.92e-03	-0.335000	4.85e-02
STAT3 nuclear events downstream of ALK signaling	11	5.50e-02	0.334000	1.95e-01
Mitochondrial protein import	63	4.53e-06	0.334000	8.42e-05
Formyl peptide receptors bind formyl peptides and many other ligands	7	1.26e-01	-0.334000	3.35e-01
Fibronectin matrix formation	6	1.57e-01	-0.333000	3.78e-01
N-Glycan antennae elongation	13	3.81e-02	-0.332000	1.56e-01
Acetylcholine binding and downstream events	5	1.99e-01	-0.332000	4.27e-01
Postsynaptic nicotinic acetylcholine receptors	5	1.99e-01	-0.332000	4.27e-01
SARS-CoV-1-host interactions	95	2.39e-08	0.331000	6.24e-07
Assembly of the ORC complex at the origin of replication	23	6.08e-03	-0.330000	3.97e-02
GP1b-IX-V activation signalling	12	4.76e-02	-0.330000	1.79e-01
Cristae formation	33	1.04e-03	0.330000	9.58e-03
Regulated proteolysis of p75NTR	11	5.98e-02	-0.328000	2.06e-01
Caspase activation via Death Receptors in the presence of ligand	16	2.34e-02	0.327000	1.10e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	4.50e-05	0.327000	6.58e-04
Specification of primordial germ cells	6	1.65e-01	-0.327000	3.89e-01
Mitochondrial iron-sulfur cluster biogenesis	13	4.14e-02	0.327000	1.64e-01
p53-Dependent G1 DNA Damage Response	52	4.58e-05	0.327000	6.60e-04
p53-Dependent G1/S DNA damage checkpoint	52	4.58e-05	0.327000	6.60e-04
Regulation of RUNX3 expression and activity	45	1.55e-04	0.326000	1.87e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	3.48e-02	0.326000	1.46e-01
MAPK3 (ERK1) activation	10	7.50e-02	-0.325000	2.41e-01
Na+/Cl- dependent neurotransmitter transporters	8	1.12e-01	-0.324000	3.13e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.37e-20	0.323000	1.11e-18
rRNA processing	213	4.21e-16	0.323000	2.71e-14
Complex III assembly	23	7.56e-03	0.322000	4.67e-02
Mitochondrial tRNA aminoacylation	21	1.09e-02	0.321000	6.39e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	2.14e-01	0.321000	4.43e-01
Translesion synthesis by POLK	17	2.25e-02	0.320000	1.07e-01
Defective CFTR causes cystic fibrosis	47	1.53e-04	0.319000	1.86e-03
Regulation of innate immune responses to cytosolic DNA	14	3.88e-02	0.319000	1.58e-01
RUNX1 regulates transcription of genes involved in WNT signaling	5	2.18e-01	-0.318000	4.49e-01
Non-integrin membrane-ECM interactions	51	8.57e-05	-0.318000	1.11e-03
Packaging Of Telomere Ends	18	1.96e-02	-0.318000	9.73e-02
p130Cas linkage to MAPK signaling for integrins	11	6.85e-02	-0.317000	2.26e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	1.22e-01	0.316000	3.29e-01
EGFR downregulation	27	4.74e-03	-0.314000	3.26e-02
Activation of Ca-permeable Kainate Receptor	9	1.03e-01	-0.314000	2.93e-01
Ionotropic activity of kainate receptors	9	1.03e-01	-0.314000	2.93e-01
CASP8 activity is inhibited	11	7.14e-02	0.314000	2.32e-01
Dimerization of procaspase-8	11	7.14e-02	0.314000	2.32e-01
Regulation by c-FLIP	11	7.14e-02	0.314000	2.32e-01
Abacavir ADME	5	2.25e-01	-0.313000	4.59e-01
CD28 dependent Vav1 pathway	12	6.02e-02	0.313000	2.06e-01
CDK-mediated phosphorylation and removal of Cdc6	60	2.73e-05	0.313000	4.18e-04
Dual Incision in GG-NER	41	5.47e-04	0.312000	5.45e-03
Translesion synthesis by POLI	17	2.60e-02	0.312000	1.18e-01
SIRT1 negatively regulates rRNA expression	22	1.19e-02	-0.310000	6.91e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	3.83e-02	-0.309000	1.57e-01
Organic anion transporters	7	1.58e-01	0.308000	3.78e-01
SARS-CoV-1 activates/modulates innate immune responses	40	7.39e-04	0.308000	7.07e-03
Mitochondrial Fatty Acid Beta-Oxidation	36	1.39e-03	0.308000	1.22e-02
Metabolism of polyamines	46	3.09e-04	0.307000	3.41e-03
Regulation of RUNX2 expression and activity	54	9.75e-05	0.307000	1.25e-03
Citric acid cycle (TCA cycle)	34	2.01e-03	0.306000	1.64e-02
Activation of NF-kappaB in B cells	54	1.06e-04	0.305000	1.34e-03
RIP-mediated NFkB activation via ZBP1	17	2.97e-02	0.305000	1.28e-01
Passive transport by Aquaporins	6	1.98e-01	-0.304000	4.26e-01
Regulation of CDH11 gene transcription	5	2.40e-01	0.304000	4.81e-01
Asymmetric localization of PCP proteins	49	2.37e-04	0.303000	2.69e-03
Mucopolysaccharidoses	11	8.14e-02	-0.303000	2.54e-01
Removal of the Flap Intermediate	14	4.93e-02	0.303000	1.81e-01
Respiratory electron transport	149	1.60e-10	0.303000	4.84e-09
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	7	1.65e-01	-0.303000	3.87e-01
RHOQ GTPase cycle	55	1.08e-04	-0.302000	1.36e-03
Defensins	8	1.40e-01	-0.301000	3.55e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	2.03e-01	-0.300000	4.33e-01
Telomere C-strand synthesis initiation	13	6.11e-02	0.300000	2.07e-01
tRNA modification in the mitochondrion	9	1.20e-01	0.299000	3.25e-01
Interleukin-27 signaling	11	8.58e-02	-0.299000	2.61e-01
G alpha (z) signalling events	36	1.94e-03	-0.298000	1.61e-02
Ribavirin ADME	11	8.75e-02	0.298000	2.63e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	1.04e-02	0.296000	6.15e-02
SOS-mediated signalling	7	1.76e-01	-0.295000	4.00e-01
Mismatch Repair	15	4.76e-02	0.295000	1.79e-01
Telomere C-strand (Lagging Strand) Synthesis	34	2.88e-03	0.295000	2.25e-02
Sphingolipid de novo biosynthesis	34	2.92e-03	-0.295000	2.28e-02
Condensation of Prophase Chromosomes	27	8.08e-03	-0.294000	4.89e-02
Formation of ATP by chemiosmotic coupling	20	2.27e-02	0.294000	1.08e-01
Activation of the AP-1 family of transcription factors	10	1.08e-01	-0.294000	3.04e-01
Interleukin-1 processing	8	1.51e-01	0.293000	3.69e-01
Hedgehog ligand biogenesis	47	5.01e-04	0.293000	5.15e-03
G1/S DNA Damage Checkpoints	54	2.10e-04	0.292000	2.45e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	6.89e-02	-0.291000	2.27e-01
GDP-fucose biosynthesis	6	2.17e-01	0.291000	4.47e-01
Platelet Aggregation (Plug Formation)	30	5.88e-03	-0.291000	3.90e-02
Serine biosynthesis	8	1.55e-01	-0.290000	3.76e-01
Cell surface interactions at the vascular wall	176	3.62e-11	-0.289000	1.23e-09
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	4.11e-04	-0.289000	4.34e-03
Pregnenolone biosynthesis	10	1.14e-01	0.288000	3.16e-01
NADE modulates death signalling	5	2.65e-01	-0.288000	5.11e-01
Removal of the Flap Intermediate from the C-strand	17	4.06e-02	0.287000	1.63e-01
Cobalamin (Cbl) metabolism	7	1.89e-01	0.286000	4.13e-01
Hyaluronan uptake and degradation	12	8.63e-02	-0.286000	2.61e-01
RHOBTB2 GTPase cycle	23	1.81e-02	0.285000	9.26e-02
mRNA decay by 3’ to 5’ exoribonuclease	13	7.55e-02	0.285000	2.42e-01
TRIF-mediated programmed cell death	9	1.40e-01	0.284000	3.54e-01
Regulation of APC/C activators between G1/S and early anaphase	68	5.12e-05	0.284000	7.33e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	1.94e-01	-0.284000	4.20e-01
Fcgamma receptor (FCGR) dependent phagocytosis	147	3.10e-09	-0.283000	8.57e-08
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	1.37e-04	0.282000	1.68e-03
Downstream TCR signaling	89	4.51e-06	0.281000	8.42e-05
Phosphorylation of Emi1	6	2.34e-01	-0.281000	4.72e-01
Metabolism of non-coding RNA	53	4.06e-04	0.281000	4.33e-03
snRNP Assembly	53	4.06e-04	0.281000	4.33e-03
Xenobiotics	12	9.22e-02	0.281000	2.72e-01
Metabolism of RNA	718	2.96e-37	0.279000	2.86e-34
Termination of translesion DNA synthesis	32	6.35e-03	0.279000	4.08e-02
Sema4D induced cell migration and growth-cone collapse	19	3.57e-02	-0.278000	1.49e-01
Aflatoxin activation and detoxification	14	7.22e-02	0.277000	2.33e-01
Maturation of TCA enzymes and regulation of TCA cycle	20	3.17e-02	0.277000	1.36e-01
Signaling by LTK in cancer	7	2.04e-01	-0.277000	4.36e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	2.06e-04	0.277000	2.41e-03
TNFR2 non-canonical NF-kB pathway	84	1.14e-05	0.277000	1.90e-04
Fructose metabolism	7	2.06e-01	0.276000	4.37e-01
Heme biosynthesis	13	8.57e-02	0.275000	2.61e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	2.09e-01	0.274000	4.38e-01
Signaling by Activin	14	7.70e-02	-0.273000	2.46e-01
PTK6 promotes HIF1A stabilization	6	2.47e-01	-0.273000	4.89e-01
Noncanonical activation of NOTCH3	8	1.82e-01	-0.273000	4.07e-01
Syndecan interactions	26	1.65e-02	-0.272000	8.63e-02
Metabolism of amino acids and derivatives	308	3.60e-16	0.270000	2.40e-14
RHOF GTPase cycle	39	3.55e-03	-0.270000	2.62e-02
RHO GTPases activate IQGAPs	25	1.96e-02	-0.270000	9.71e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	2.86e-02	-0.270000	1.26e-01
Reactions specific to the complex N-glycan synthesis pathway	7	2.21e-01	-0.267000	4.54e-01
RHOB GTPase cycle	65	1.98e-04	-0.267000	2.33e-03
Signaling by Leptin	10	1.46e-01	-0.265000	3.63e-01
Displacement of DNA glycosylase by APEX1	9	1.68e-01	0.265000	3.91e-01
Signaling by EGFR	48	1.49e-03	-0.265000	1.29e-02
Processive synthesis on the C-strand of the telomere	19	4.63e-02	0.264000	1.76e-01
Alternative complement activation	5	3.09e-01	0.263000	5.60e-01
Host Interactions of HIV factors	118	8.26e-07	0.263000	1.86e-05
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	1.16e-01	-0.262000	3.17e-01
Amino acid transport across the plasma membrane	26	2.07e-02	-0.262000	1.01e-01
Germ layer formation at gastrulation	9	1.74e-01	-0.262000	3.98e-01
RNA Polymerase II Transcription Termination	66	2.46e-04	0.261000	2.78e-03
NFE2L2 regulating ER-stress associated genes	5	3.13e-01	-0.261000	5.62e-01
Cellular response to hypoxia	59	5.37e-04	0.261000	5.43e-03
Aerobic respiration and respiratory electron transport	245	2.18e-12	0.260000	8.43e-11
Gluconeogenesis	19	4.98e-02	0.260000	1.82e-01
RUNX3 regulates NOTCH signaling	14	9.46e-02	-0.258000	2.77e-01
ECM proteoglycans	48	2.00e-03	-0.258000	1.64e-02
Formation of paraxial mesoderm	52	1.32e-03	0.257000	1.17e-02
Caspase-mediated cleavage of cytoskeletal proteins	12	1.23e-01	-0.257000	3.30e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	5.09e-04	0.257000	5.20e-03
PKA activation	15	8.53e-02	-0.257000	2.61e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	63	4.29e-04	0.256000	4.46e-03
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	3.21e-01	0.256000	5.70e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	1.15e-04	0.256000	1.43e-03
TLR3-mediated TICAM1-dependent programmed cell death	6	2.79e-01	0.255000	5.27e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	7.78e-02	-0.255000	2.46e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	6.64e-03	0.254000	4.23e-02
Class I peroxisomal membrane protein import	20	4.91e-02	0.254000	1.81e-01
GRB2 events in EGFR signaling	11	1.45e-01	-0.254000	3.62e-01
tRNA modification in the nucleus and cytosol	43	4.02e-03	0.254000	2.86e-02
MET activates RAS signaling	10	1.66e-01	-0.253000	3.89e-01
TCR signaling	110	4.67e-06	0.253000	8.59e-05
Pyroptosis	25	2.89e-02	0.252000	1.27e-01
Glycogen breakdown (glycogenolysis)	12	1.31e-01	-0.252000	3.42e-01
SHC1 events in EGFR signaling	12	1.31e-01	-0.252000	3.42e-01
Pyrimidine salvage	10	1.68e-01	-0.252000	3.91e-01
EGFR interacts with phospholipase C-gamma	7	2.49e-01	-0.251000	4.92e-01
Orc1 removal from chromatin	58	9.26e-04	0.251000	8.60e-03
Acetylcholine regulates insulin secretion	9	1.92e-01	0.251000	4.17e-01
Alpha-oxidation of phytanate	6	2.87e-01	0.251000	5.36e-01
Interconversion of nucleotide di- and triphosphates	27	2.38e-02	0.251000	1.12e-01
Insulin receptor signalling cascade	40	6.05e-03	-0.251000	3.97e-02
Protein localization	157	6.67e-08	0.250000	1.72e-06
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	4.29e-02	0.249000	1.69e-01
Pexophagy	10	1.72e-01	0.249000	3.96e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	1.35e-01	-0.249000	3.47e-01
Transport of connexons to the plasma membrane	12	1.35e-01	-0.249000	3.47e-01
Mitochondrial protein degradation	96	2.45e-05	0.249000	3.81e-04
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	5.99e-04	0.248000	5.90e-03
Defective HLCS causes multiple carboxylase deficiency	7	2.56e-01	0.248000	4.99e-01
RNA Polymerase I Transcription Initiation	47	3.31e-03	0.248000	2.53e-02
Activation of PUMA and translocation to mitochondria	9	1.99e-01	-0.247000	4.27e-01
RUNX2 regulates bone development	26	2.92e-02	-0.247000	1.27e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	2.93e-04	0.247000	3.25e-03
Leishmania infection	211	7.29e-10	-0.246000	2.07e-08
Parasitic Infection Pathways	211	7.29e-10	-0.246000	2.07e-08
Hedgehog ‘on’ state	65	6.08e-04	0.246000	5.96e-03
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	4.14e-02	-0.246000	1.64e-01
Cleavage of the damaged purine	22	4.62e-02	-0.246000	1.76e-01
Depurination	22	4.62e-02	-0.246000	1.76e-01
Recognition and association of DNA glycosylase with site containing an affected purine	22	4.62e-02	-0.246000	1.76e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	2.17e-04	0.245000	2.48e-03
Activation of AMPK downstream of NMDARs	20	5.75e-02	-0.245000	2.02e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	1.04e-04	0.245000	1.33e-03
SARS-CoV-1 Infection	138	7.11e-07	0.244000	1.65e-05
Phospholipase C-mediated cascade; FGFR4	6	3.01e-01	0.244000	5.50e-01
PKA activation in glucagon signalling	14	1.14e-01	-0.244000	3.16e-01
RHOC GTPase cycle	72	3.54e-04	-0.243000	3.84e-03
The activation of arylsulfatases	10	1.84e-01	-0.243000	4.08e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	18	7.59e-02	0.242000	2.43e-01
Complex IV assembly	45	5.15e-03	0.241000	3.50e-02
rRNA processing in the mitochondrion	24	4.11e-02	-0.241000	1.64e-01
Regulation of signaling by NODAL	6	3.08e-01	-0.240000	5.59e-01
Interleukin-35 Signalling	12	1.49e-01	-0.240000	3.68e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.88e-01	0.240000	4.12e-01
Recognition of DNA damage by PCNA-containing replication complex	30	2.30e-02	0.240000	1.09e-01
MET promotes cell motility	33	1.72e-02	-0.240000	8.90e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	1.69e-01	0.240000	3.92e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.69e-01	-0.239000	3.93e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	2.41e-01	-0.239000	4.83e-01
Olfactory Signaling Pathway	61	1.25e-03	-0.239000	1.11e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	1.36e-01	0.239000	3.48e-01
ER-Phagosome pathway	75	3.59e-04	0.238000	3.87e-03
RHOD GTPase cycle	50	3.57e-03	-0.238000	2.62e-02
Signaling by Hippo	18	8.17e-02	-0.237000	2.54e-01
PI-3K cascade:FGFR4	11	1.74e-01	-0.237000	3.97e-01
NOTCH2 intracellular domain regulates transcription	11	1.74e-01	-0.237000	3.97e-01
Transcriptional regulation of pluripotent stem cells	21	6.04e-02	-0.237000	2.06e-01
Advanced glycosylation endproduct receptor signaling	12	1.56e-01	-0.237000	3.76e-01
Protein hydroxylation	17	9.12e-02	0.237000	2.71e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	2.79e-01	-0.236000	5.27e-01
TGFBR3 PTM regulation	10	1.96e-01	-0.236000	4.25e-01
MAPK1 (ERK2) activation	9	2.21e-01	-0.235000	4.55e-01
SLC15A4:TASL-dependent IRF5 activation	6	3.18e-01	-0.235000	5.67e-01
FRS-mediated FGFR1 signaling	15	1.15e-01	-0.235000	3.16e-01
Apoptotic cleavage of cellular proteins	35	1.62e-02	-0.235000	8.54e-02
ZBP1(DAI) mediated induction of type I IFNs	20	6.91e-02	0.235000	2.27e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	2.50e-01	-0.235000	4.93e-01
Signaling by activated point mutants of FGFR1	5	3.64e-01	-0.235000	6.04e-01
Condensation of Prometaphase Chromosomes	11	1.79e-01	-0.234000	4.02e-01
mRNA 3’-end processing	57	2.24e-03	0.234000	1.81e-02
Switching of origins to a post-replicative state	79	3.30e-04	0.234000	3.62e-03
Activated NTRK2 signals through FRS2 and FRS3	8	2.53e-01	-0.234000	4.96e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	1.48e-03	0.233000	1.28e-02
Membrane binding and targetting of GAG proteins	13	1.45e-01	0.233000	3.62e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	1.45e-01	0.233000	3.62e-01
Uptake and function of anthrax toxins	11	1.81e-01	-0.233000	4.06e-01
Laminin interactions	26	4.01e-02	-0.233000	1.62e-01
VEGF binds to VEGFR leading to receptor dimerization	5	3.68e-01	-0.233000	6.06e-01
VEGF ligand-receptor interactions	5	3.68e-01	-0.233000	6.06e-01
Triglyceride biosynthesis	10	2.03e-01	-0.232000	4.34e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	1.08e-01	0.232000	3.04e-01
Establishment of Sister Chromatid Cohesion	11	1.83e-01	-0.232000	4.07e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	6.07e-02	-0.231000	2.06e-01
Downstream signaling events of B Cell Receptor (BCR)	68	9.90e-04	0.231000	9.15e-03
Regulation of TP53 Activity through Methylation	19	8.17e-02	0.231000	2.54e-01
Degradation of beta-catenin by the destruction complex	72	7.16e-04	0.231000	6.88e-03
Interactions of Vpr with host cellular proteins	37	1.52e-02	0.231000	8.20e-02
The NLRP3 inflammasome	16	1.11e-01	0.230000	3.11e-01
Calcitonin-like ligand receptors	5	3.73e-01	-0.230000	6.11e-01
Pre-NOTCH Transcription and Translation	47	6.45e-03	-0.230000	4.12e-02
Regulation of PTEN stability and activity	55	3.27e-03	0.229000	2.52e-02
CLEC7A/inflammasome pathway	6	3.31e-01	0.229000	5.81e-01
Cleavage of the damaged pyrimidine	27	3.93e-02	-0.229000	1.60e-01
Depyrimidination	27	3.93e-02	-0.229000	1.60e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	3.93e-02	-0.229000	1.60e-01
Small interfering RNA (siRNA) biogenesis	9	2.35e-01	-0.229000	4.73e-01
PI3K events in ERBB2 signaling	11	1.89e-01	-0.229000	4.13e-01
Downregulation of ERBB2:ERBB3 signaling	12	1.72e-01	0.228000	3.96e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	1.55e-02	-0.227000	8.26e-02
Nucleosome assembly	38	1.55e-02	-0.227000	8.26e-02
Regulation of RAS by GAPs	55	3.61e-03	0.227000	2.63e-02
Defects in cobalamin (B12) metabolism	13	1.58e-01	0.226000	3.78e-01
Sema4D in semaphorin signaling	22	6.64e-02	-0.226000	2.21e-01
Glycosphingolipid transport	7	3.01e-01	0.226000	5.50e-01
ADORA2B mediated anti-inflammatory cytokines production	36	1.94e-02	-0.225000	9.66e-02
Activated NTRK3 signals through PI3K	5	3.83e-01	-0.225000	6.20e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	6.27e-02	0.224000	2.09e-01
SARS-CoV-2 modulates autophagy	11	1.99e-01	0.224000	4.27e-01
InlA-mediated entry of Listeria monocytogenes into host cells	9	2.45e-01	0.224000	4.87e-01
Presynaptic depolarization and calcium channel opening	8	2.74e-01	0.223000	5.20e-01
CLEC7A (Dectin-1) signaling	86	3.47e-04	0.223000	3.79e-03
Polo-like kinase mediated events	16	1.23e-01	-0.222000	3.32e-01
Evasion by RSV of host interferon responses	20	8.51e-02	0.222000	2.61e-01
Regulation of localization of FOXO transcription factors	11	2.02e-01	-0.222000	4.32e-01
APC/C-mediated degradation of cell cycle proteins	75	8.82e-04	0.222000	8.28e-03
Regulation of mitotic cell cycle	75	8.82e-04	0.222000	8.28e-03
Defective RIPK1-mediated regulated necrosis	7	3.09e-01	0.222000	5.60e-01
Activation of G protein gated Potassium channels	20	8.60e-02	-0.222000	2.61e-01
G protein gated Potassium channels	20	8.60e-02	-0.222000	2.61e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	8.60e-02	-0.222000	2.61e-01
Beta-catenin phosphorylation cascade	17	1.15e-01	-0.221000	3.16e-01
Synthesis of DNA	108	7.76e-05	0.220000	1.03e-03
The role of GTSE1 in G2/M progression after G2 checkpoint	59	3.52e-03	0.220000	2.62e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	4.45e-02	0.219000	1.73e-01
PI3K Cascade	31	3.47e-02	-0.219000	1.46e-01
Signaling by Retinoic Acid	29	4.11e-02	0.219000	1.64e-01
Nucleotide Excision Repair	108	8.46e-05	0.219000	1.11e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	2.95e-02	-0.219000	1.28e-01
Defects in vitamin and cofactor metabolism	21	8.28e-02	0.219000	2.57e-01
Negative feedback regulation of MAPK pathway	6	3.54e-01	-0.219000	5.98e-01
Glucagon signaling in metabolic regulation	26	5.39e-02	-0.218000	1.92e-01
Transport of Mature Transcript to Cytoplasm	81	6.82e-04	0.218000	6.62e-03
Expression and translocation of olfactory receptors	56	4.73e-03	-0.218000	3.26e-02
ADP signalling through P2Y purinoceptor 12	18	1.09e-01	-0.218000	3.07e-01
FOXO-mediated transcription of cell cycle genes	15	1.44e-01	-0.218000	3.61e-01
Translesion Synthesis by POLH	18	1.09e-01	0.218000	3.07e-01
Dual incision in TC-NER	63	2.80e-03	0.218000	2.21e-02
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	1.44e-01	0.218000	3.62e-01
ABC transporter disorders	60	3.55e-03	0.218000	2.62e-02
Vpr-mediated nuclear import of PICs	34	2.88e-02	0.217000	1.27e-01
rRNA modification in the mitochondrion	8	2.90e-01	0.216000	5.39e-01
CREB3 factors activate genes	6	3.60e-01	-0.216000	6.00e-01
RHOG GTPase cycle	71	1.72e-03	-0.215000	1.47e-02
Synthesis of PIPs at the plasma membrane	52	7.29e-03	-0.215000	4.56e-02
DNA Damage Recognition in GG-NER	38	2.19e-02	0.215000	1.05e-01
Interactions of Rev with host cellular proteins	37	2.39e-02	0.215000	1.12e-01
NPAS4 regulates expression of target genes	16	1.38e-01	-0.214000	3.51e-01
Apoptotic execution phase	46	1.20e-02	-0.214000	6.94e-02
Myoclonic epilepsy of Lafora	8	2.96e-01	0.213000	5.46e-01
Cellular response to mitochondrial stress	9	2.68e-01	0.213000	5.15e-01
Meiotic recombination	37	2.51e-02	-0.213000	1.15e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	2.44e-01	-0.213000	4.86e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	2.02e-01	-0.213000	4.33e-01
Phospholipase C-mediated cascade; FGFR2	8	2.99e-01	0.212000	5.49e-01
Bicarbonate transporters	9	2.71e-01	0.212000	5.19e-01
Nuclear import of Rev protein	34	3.26e-02	0.212000	1.39e-01
Formation of definitive endoderm	9	2.72e-01	-0.212000	5.19e-01
Interferon gamma signaling	90	5.25e-04	0.211000	5.34e-03
Defective GALNT3 causes HFTC	9	2.72e-01	-0.211000	5.19e-01
RAB geranylgeranylation	61	4.29e-03	-0.211000	3.00e-02
Platelet degranulation	106	1.81e-04	-0.210000	2.14e-03
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	3.35e-01	0.210000	5.83e-01
Urea cycle	7	3.36e-01	-0.210000	5.84e-01
Sphingolipid metabolism	91	5.43e-04	-0.210000	5.45e-03
Serotonin Neurotransmitter Release Cycle	15	1.60e-01	0.210000	3.82e-01
SUMOylation of immune response proteins	12	2.09e-01	0.209000	4.38e-01
Formation of Incision Complex in GG-NER	43	1.77e-02	0.209000	9.13e-02
Downregulation of ERBB4 signaling	8	3.06e-01	0.209000	5.58e-01
Signaling by MET	68	3.00e-03	-0.208000	2.33e-02
Signalling to ERKs	32	4.19e-02	-0.208000	1.65e-01
Antigen processing-Cross presentation	89	7.05e-04	0.208000	6.81e-03
Activation of C3 and C5	7	3.42e-01	-0.208000	5.91e-01
Miscellaneous transport and binding events	20	1.09e-01	-0.207000	3.06e-01
RNA Polymerase I Transcription Termination	30	4.96e-02	0.207000	1.82e-01
Cargo trafficking to the periciliary membrane	47	1.42e-02	0.207000	7.94e-02
Dectin-2 family	19	1.20e-01	-0.206000	3.25e-01
Chondroitin sulfate/dermatan sulfate metabolism	38	2.79e-02	-0.206000	1.25e-01
Defects in biotin (Btn) metabolism	8	3.13e-01	0.206000	5.62e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	1.84e-01	-0.205000	4.09e-01
Synthesis of PI	5	4.28e-01	0.205000	6.55e-01
FGFR2 mutant receptor activation	23	8.94e-02	0.205000	2.67e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	1.45e-01	0.204000	3.62e-01
Response to elevated platelet cytosolic Ca2+	110	2.12e-04	-0.204000	2.46e-03
IGF1R signaling cascade	38	2.94e-02	-0.204000	1.28e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	3.87e-01	0.204000	6.20e-01
HDL assembly	6	3.87e-01	-0.204000	6.20e-01
rRNA modification in the nucleus and cytosol	59	6.80e-03	0.204000	4.31e-02
IRS-related events triggered by IGF1R	37	3.22e-02	-0.203000	1.38e-01
Biotin transport and metabolism	11	2.43e-01	0.203000	4.83e-01
Nephrin family interactions	20	1.16e-01	-0.203000	3.17e-01
Signaling by FGFR2 IIIa TM	18	1.36e-01	0.203000	3.48e-01
Phase 3 - rapid repolarisation	6	3.90e-01	0.203000	6.23e-01
Gamma-carboxylation of protein precursors	6	3.90e-01	0.203000	6.23e-01
HIV Infection	213	3.50e-07	0.202000	8.34e-06
Intraflagellar transport	47	1.63e-02	0.202000	8.59e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	4.43e-02	0.202000	1.73e-01
Impaired BRCA2 binding to PALB2	24	8.65e-02	-0.202000	2.61e-01
Cyclin A:Cdk2-associated events at S phase entry	75	2.48e-03	0.202000	1.99e-02
Activation of the phototransduction cascade	8	3.22e-01	-0.202000	5.72e-01
Signaling by PDGF	50	1.35e-02	-0.202000	7.61e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	3.60e-02	0.202000	1.49e-01
Long-term potentiation	18	1.39e-01	0.201000	3.53e-01
SHC1 events in ERBB2 signaling	17	1.51e-01	-0.201000	3.69e-01
Activation of GABAB receptors	31	5.30e-02	-0.201000	1.90e-01
GABA B receptor activation	31	5.30e-02	-0.201000	1.90e-01
Netrin-1 signaling	35	4.00e-02	-0.201000	1.62e-01
Attachment of GPI anchor to uPAR	7	3.58e-01	0.201000	6.00e-01
Viral Messenger RNA Synthesis	44	2.16e-02	0.200000	1.04e-01
Pre-NOTCH Expression and Processing	63	6.02e-03	-0.200000	3.97e-02
Signaling by Insulin receptor	63	6.07e-03	-0.200000	3.97e-02
Eicosanoid ligand-binding receptors	13	2.13e-01	-0.200000	4.41e-01
DNA Damage Bypass	47	1.80e-02	0.199000	9.25e-02
Cellular response to heat stress	94	8.31e-04	0.199000	7.91e-03
NFE2L2 regulating anti-oxidant/detoxification enzymes	17	1.55e-01	-0.199000	3.75e-01
GABA receptor activation	38	3.35e-02	-0.199000	1.42e-01
STAT5 activation downstream of FLT3 ITD mutants	9	3.01e-01	-0.199000	5.50e-01
Fertilization	12	2.33e-01	0.199000	4.72e-01
Formation of the Early Elongation Complex	33	4.81e-02	0.199000	1.80e-01
Formation of the HIV-1 Early Elongation Complex	33	4.81e-02	0.199000	1.80e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	3.99e-01	0.199000	6.29e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	4.51e-02	-0.199000	1.73e-01
Regulation of IFNA/IFNB signaling	12	2.34e-01	0.199000	4.72e-01
SARS-CoV-2-host interactions	183	3.74e-06	0.198000	7.29e-05
Regulation of Expression and Function of Type II Classical Cadherins	25	8.65e-02	0.198000	2.61e-01
Regulation of Homotypic Cell-Cell Adhesion	25	8.65e-02	0.198000	2.61e-01
Androgen biosynthesis	5	4.43e-01	0.198000	6.67e-01
Maternal to zygotic transition (MZT)	72	3.68e-03	-0.198000	2.66e-02
IRS-mediated signalling	35	4.27e-02	-0.198000	1.68e-01
Aquaporin-mediated transport	38	3.49e-02	-0.198000	1.46e-01
Resolution of D-Loop Structures	35	4.31e-02	-0.198000	1.69e-01
CTNNB1 S33 mutants aren’t phosphorylated	15	1.86e-01	-0.197000	4.09e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	1.86e-01	-0.197000	4.09e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	1.86e-01	-0.197000	4.09e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	1.86e-01	-0.197000	4.09e-01
Signaling by CTNNB1 phospho-site mutants	15	1.86e-01	-0.197000	4.09e-01
Signaling by GSK3beta mutants	15	1.86e-01	-0.197000	4.09e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	2.01e-01	-0.197000	4.31e-01
ISG15 antiviral mechanism	72	3.80e-03	0.197000	2.74e-02
Arachidonate production from DAG	5	4.46e-01	-0.197000	6.70e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	1.87e-01	0.197000	4.12e-01
RHO GTPases Activate ROCKs	18	1.49e-01	-0.196000	3.67e-01
Transcriptional Regulation by VENTX	39	3.39e-02	0.196000	1.43e-01
Extension of Telomeres	51	1.54e-02	0.196000	8.26e-02
Transport of bile salts and organic acids, metal ions and amine compounds	52	1.45e-02	-0.196000	8.03e-02
Inwardly rectifying K+ channels	24	9.65e-02	-0.196000	2.80e-01
Nuclear events stimulated by ALK signaling in cancer	33	5.18e-02	0.196000	1.88e-01
TNFR1-induced NF-kappa-B signaling pathway	32	5.59e-02	0.195000	1.97e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	9.11e-02	0.195000	2.71e-01
Norepinephrine Neurotransmitter Release Cycle	14	2.06e-01	0.195000	4.37e-01
Cyclin E associated events during G1/S transition	73	3.98e-03	0.195000	2.85e-02
Synthesis of PE	12	2.43e-01	-0.195000	4.83e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	1.94e-03	-0.194000	1.61e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	1.94e-03	-0.194000	1.61e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	1.94e-03	-0.194000	1.61e-02
Downstream signaling of activated FGFR3	17	1.66e-01	-0.194000	3.89e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	4.46e-02	-0.193000	1.73e-01
Chaperone Mediated Autophagy	20	1.34e-01	0.193000	3.46e-01
Hyaluronan metabolism	16	1.81e-01	-0.193000	4.06e-01
APC truncation mutants have impaired AXIN binding	14	2.11e-01	-0.193000	4.38e-01
AXIN missense mutants destabilize the destruction complex	14	2.11e-01	-0.193000	4.38e-01
Signaling by AMER1 mutants	14	2.11e-01	-0.193000	4.38e-01
Signaling by APC mutants	14	2.11e-01	-0.193000	4.38e-01
Signaling by AXIN mutants	14	2.11e-01	-0.193000	4.38e-01
Truncations of AMER1 destabilize the destruction complex	14	2.11e-01	-0.193000	4.38e-01
HIV Transcription Initiation	45	2.51e-02	0.193000	1.15e-01
RNA Polymerase II HIV Promoter Escape	45	2.51e-02	0.193000	1.15e-01
RNA Polymerase II Promoter Escape	45	2.51e-02	0.193000	1.15e-01
RNA Polymerase II Transcription Initiation	45	2.51e-02	0.193000	1.15e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	2.51e-02	0.193000	1.15e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	2.51e-02	0.193000	1.15e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	4.14e-01	0.193000	6.41e-01
Cytosolic sulfonation of small molecules	18	1.57e-01	-0.193000	3.78e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	3.78e-01	0.192000	6.16e-01
Platelet activation, signaling and aggregation	223	7.44e-07	-0.192000	1.71e-05
Loss of Function of SMAD2/3 in Cancer	7	3.79e-01	-0.192000	6.16e-01
Hedgehog ‘off’ state	91	1.56e-03	0.192000	1.33e-02
PKA-mediated phosphorylation of CREB	17	1.71e-01	-0.192000	3.96e-01
Synthesis of pyrophosphates in the cytosol	8	3.49e-01	-0.191000	5.98e-01
Formation of TC-NER Pre-Incision Complex	51	1.85e-02	0.191000	9.38e-02
tRNA processing in the nucleus	59	1.14e-02	0.190000	6.64e-02
MAPK6/MAPK4 signaling	69	6.24e-03	0.190000	4.05e-02
Interleukin-9 signaling	8	3.53e-01	0.189000	5.98e-01
Glutathione synthesis and recycling	10	3.00e-01	0.189000	5.49e-01
Branched-chain ketoacid dehydrogenase kinase deficiency	5	4.63e-01	-0.189000	6.84e-01
Synthesis of Dolichyl-phosphate	6	4.22e-01	0.189000	6.48e-01
Postmitotic nuclear pore complex (NPC) reformation	27	8.90e-02	0.189000	2.66e-01
Signaling by FLT3 ITD and TKD mutants	15	2.05e-01	-0.189000	4.37e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	2.79e-01	-0.189000	5.27e-01
Sulfide oxidation to sulfate	5	4.67e-01	0.188000	6.86e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.81e-01	-0.188000	5.30e-01
Budding and maturation of HIV virion	26	9.88e-02	0.187000	2.85e-01
Rev-mediated nuclear export of HIV RNA	35	5.55e-02	0.187000	1.96e-01
Alpha-protein kinase 1 signaling pathway	11	2.83e-01	0.187000	5.31e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	29	8.15e-02	0.187000	2.54e-01
Signaling by NOTCH4	70	6.88e-03	0.187000	4.35e-02
Hemostasis	562	3.64e-14	-0.187000	1.76e-12
Pausing and recovery of Tat-mediated HIV elongation	30	7.73e-02	0.186000	2.46e-01
Tat-mediated HIV elongation arrest and recovery	30	7.73e-02	0.186000	2.46e-01
PRC2 methylates histones and DNA	27	9.41e-02	-0.186000	2.76e-01
Regulation of HSF1-mediated heat shock response	79	4.29e-03	0.186000	3.00e-02
Loss of Function of TGFBR1 in Cancer	7	3.95e-01	-0.186000	6.26e-01
Maturation of spike protein 9683686	5	4.73e-01	-0.185000	6.90e-01
Interleukin-37 signaling	19	1.62e-01	-0.185000	3.83e-01
Glycosaminoglycan metabolism	98	1.52e-03	-0.185000	1.31e-02
Regulated Necrosis	56	1.65e-02	0.185000	8.63e-02
Synthesis of PC	23	1.25e-01	-0.185000	3.33e-01
Aspartate and asparagine metabolism	9	3.39e-01	0.184000	5.88e-01
Base-Excision Repair, AP Site Formation	29	8.66e-02	-0.184000	2.61e-01
Plasma lipoprotein remodeling	18	1.77e-01	-0.184000	4.01e-01
Interferon Signaling	240	9.46e-07	0.184000	2.10e-05
Interleukin-10 signaling	38	5.04e-02	0.183000	1.83e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	2.52e-01	0.183000	4.96e-01
Disorders of Developmental Biology	12	2.72e-01	0.183000	5.19e-01
Disorders of Nervous System Development	12	2.72e-01	0.183000	5.19e-01
Loss of function of MECP2 in Rett syndrome	12	2.72e-01	0.183000	5.19e-01
Pervasive developmental disorders	12	2.72e-01	0.183000	5.19e-01
Metabolism of nucleotides	85	3.60e-03	0.183000	2.63e-02
PI-3K cascade:FGFR2	13	2.54e-01	-0.183000	4.97e-01
GPER1 signaling	38	5.23e-02	-0.182000	1.88e-01
Maturation of spike protein 9694548	36	5.89e-02	-0.182000	2.05e-01
Metabolism of porphyrins	23	1.32e-01	0.182000	3.42e-01
Sphingolipid catabolism	11	2.97e-01	-0.182000	5.48e-01
Integrin signaling	22	1.41e-01	-0.181000	3.56e-01
RUNX3 regulates CDKN1A transcription	7	4.07e-01	-0.181000	6.37e-01
RUNX2 regulates osteoblast differentiation	21	1.51e-01	-0.181000	3.71e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	3.76e-01	-0.181000	6.14e-01
RHO GTPases activate PAKs	20	1.62e-01	-0.180000	3.84e-01
Netrin mediated repulsion signals	5	4.86e-01	0.180000	6.99e-01
PCP/CE pathway	75	7.08e-03	0.180000	4.46e-02
Negative regulators of DDX58/IFIH1 signaling	34	7.02e-02	0.179000	2.29e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	4.47e-01	-0.179000	6.70e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	4.47e-01	-0.179000	6.70e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	7.98e-02	0.179000	2.51e-01
DCC mediated attractive signaling	13	2.65e-01	-0.179000	5.11e-01
Cell-extracellular matrix interactions	16	2.17e-01	-0.178000	4.47e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	39	5.43e-02	-0.178000	1.93e-01
Sodium/Calcium exchangers	9	3.55e-01	-0.178000	5.98e-01
ABC-family proteins mediated transport	81	5.65e-03	0.178000	3.80e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	187	2.78e-05	-0.178000	4.23e-04
Depolymerization of the Nuclear Lamina	15	2.34e-01	-0.178000	4.72e-01
Assembly Of The HIV Virion	15	2.34e-01	0.177000	4.72e-01
Downstream signaling of activated FGFR1	22	1.50e-01	-0.177000	3.69e-01
Interleukin-20 family signaling	17	2.06e-01	0.177000	4.37e-01
RAS signaling downstream of NF1 loss-of-function variants	7	4.18e-01	-0.177000	6.44e-01
Cytosolic sensors of pathogen-associated DNA	63	1.51e-02	0.177000	8.20e-02
FRS-mediated FGFR3 signaling	12	2.92e-01	-0.176000	5.42e-01
PTEN Regulation	127	6.30e-04	0.176000	6.15e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	50	3.17e-02	-0.176000	1.36e-01
Collagen degradation	44	4.51e-02	-0.175000	1.73e-01
HS-GAG biosynthesis	20	1.78e-01	-0.174000	4.01e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	1.32e-01	-0.174000	3.42e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	1.32e-01	-0.174000	3.42e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	1.32e-01	-0.174000	3.42e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	1.32e-01	-0.174000	3.42e-01
Costimulation by the CD28 family	74	9.65e-03	0.174000	5.76e-02
Late endosomal microautophagy	30	9.97e-02	0.174000	2.86e-01
Biosynthesis of E-series 18(S)-resolvins	5	5.02e-01	-0.174000	7.13e-01
SUMOylation of SUMOylation proteins	35	7.75e-02	0.172000	2.46e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	7.37e-02	-0.172000	2.37e-01
Amine ligand-binding receptors	10	3.48e-01	0.171000	5.97e-01
Diseases of Base Excision Repair	5	5.07e-01	0.171000	7.17e-01
Thrombin signalling through proteinase activated receptors (PARs)	27	1.24e-01	-0.171000	3.32e-01
Processing of Capped Intronless Pre-mRNA	29	1.11e-01	0.171000	3.11e-01
HIV Life Cycle	144	4.08e-04	0.171000	4.33e-03
Activation of Matrix Metalloproteinases	22	1.67e-01	-0.170000	3.90e-01
Signaling by WNT in cancer	30	1.07e-01	-0.170000	3.03e-01
Sensing of DNA Double Strand Breaks	6	4.72e-01	0.170000	6.90e-01
Semaphorin interactions	56	2.87e-02	-0.169000	1.26e-01
Suppression of phagosomal maturation	12	3.13e-01	0.168000	5.62e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	3.34e-01	0.168000	5.82e-01
Kidney development	17	2.30e-01	-0.168000	4.68e-01
Histidine catabolism	7	4.42e-01	-0.168000	6.67e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	5.99e-02	0.168000	2.06e-01
HIV Transcription Elongation	42	5.99e-02	0.168000	2.06e-01
Tat-mediated elongation of the HIV-1 transcript	42	5.99e-02	0.168000	2.06e-01
Gain-of-function MRAS complexes activate RAF signaling	8	4.12e-01	0.168000	6.40e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	4.12e-01	0.168000	6.40e-01
Signaling by MRAS-complex mutants	8	4.12e-01	0.168000	6.40e-01
Regulation of CDH11 function	10	3.59e-01	0.167000	6.00e-01
NS1 Mediated Effects on Host Pathways	40	6.70e-02	0.167000	2.22e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	1.32e-01	0.167000	3.42e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.32e-01	0.167000	3.42e-01
Regulation of TP53 Activity through Acetylation	29	1.19e-01	0.167000	3.24e-01
Neurotoxicity of clostridium toxins	9	3.86e-01	0.167000	6.20e-01
G1/S-Specific Transcription	29	1.20e-01	-0.167000	3.25e-01
HDR through MMEJ (alt-NHEJ)	12	3.17e-01	0.167000	5.66e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	4.46e-01	-0.166000	6.70e-01
Ras activation upon Ca2+ influx through NMDA receptor	18	2.23e-01	0.166000	4.56e-01
Effects of PIP2 hydrolysis	24	1.60e-01	-0.166000	3.82e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	4.47e-01	0.166000	6.70e-01
FLT3 signaling by CBL mutants	7	4.48e-01	0.166000	6.70e-01
Glycosphingolipid catabolism	31	1.12e-01	-0.165000	3.13e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	9.68e-02	-0.165000	2.80e-01
UCH proteinases	73	1.52e-02	0.164000	8.20e-02
Unwinding of DNA	12	3.25e-01	-0.164000	5.74e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	3.94e-01	0.164000	6.26e-01
Negative regulation of the PI3K/AKT network	93	6.33e-03	-0.164000	4.07e-02
Negative regulation of FGFR1 signaling	25	1.57e-01	-0.164000	3.78e-01
E2F-enabled inhibition of pre-replication complex formation	9	3.96e-01	-0.163000	6.26e-01
Degradation of the extracellular matrix	99	5.02e-03	-0.163000	3.43e-02
Activation of BAD and translocation to mitochondria	15	2.74e-01	-0.163000	5.20e-01
COPI-independent Golgi-to-ER retrograde traffic	45	5.89e-02	-0.163000	2.05e-01
Mitochondrial calcium ion transport	22	1.87e-01	0.163000	4.11e-01
p75NTR negatively regulates cell cycle via SC1	5	5.29e-01	0.162000	7.37e-01
Adenylate cyclase inhibitory pathway	11	3.51e-01	-0.162000	5.98e-01
Regulation of CDH11 Expression and Function	23	1.79e-01	0.162000	4.02e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	4.28e-01	-0.162000	6.55e-01
DNA strand elongation	32	1.15e-01	0.161000	3.16e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	3.15e-01	-0.161000	5.64e-01
TNFR1-induced proapoptotic signaling	24	1.73e-01	0.161000	3.97e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.74e-01	0.160000	3.98e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	2.83e-01	0.160000	5.31e-01
CS/DS degradation	9	4.06e-01	-0.160000	6.36e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	1.31e-01	-0.159000	3.42e-01
Erythropoietin activates RAS	13	3.20e-01	-0.159000	5.69e-01
Nucleotide salvage	21	2.08e-01	0.159000	4.38e-01
DARPP-32 events	22	1.98e-01	-0.159000	4.26e-01
Defective C1GALT1C1 causes TNPS	10	3.85e-01	-0.159000	6.20e-01
Basigin interactions	23	1.88e-01	-0.158000	4.12e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.54e-01	-0.158000	3.75e-01
Export of Viral Ribonucleoproteins from Nucleus	33	1.16e-01	0.158000	3.17e-01
Cohesin Loading onto Chromatin	10	3.87e-01	-0.158000	6.20e-01
Calcineurin activates NFAT	9	4.12e-01	-0.158000	6.40e-01
Neurotransmitter receptors and postsynaptic signal transmission	141	1.22e-03	-0.158000	1.11e-02
Formation of the cornified envelope	36	1.02e-01	-0.158000	2.90e-01
mRNA Capping	29	1.42e-01	0.158000	3.57e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.23e-01	0.157000	4.56e-01
Tie2 Signaling	16	2.77e-01	-0.157000	5.23e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.64e-01	0.157000	5.11e-01
IFNG signaling activates MAPKs	8	4.44e-01	-0.156000	6.67e-01
Neutrophil degranulation	458	9.85e-09	-0.156000	2.64e-07
Vitamin D (calciferol) metabolism	11	3.70e-01	0.156000	6.07e-01
FGFR1 mutant receptor activation	25	1.77e-01	-0.156000	4.01e-01
Defective pyroptosis	27	1.61e-01	-0.156000	3.82e-01
SHC-mediated cascade:FGFR1	13	3.32e-01	-0.155000	5.82e-01
Signal amplification	28	1.55e-01	-0.155000	3.75e-01
RNA Polymerase II Pre-transcription Events	77	1.84e-02	0.155000	9.38e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	3.96e-01	-0.155000	6.26e-01
Triglyceride metabolism	26	1.71e-01	-0.155000	3.96e-01
Extracellular matrix organization	222	7.01e-05	-0.155000	9.61e-04
Regulation of beta-cell development	22	2.09e-01	-0.155000	4.38e-01
Regulation of IFNG signaling	14	3.16e-01	-0.155000	5.65e-01
Transport of the SLBP Dependant Mature mRNA	36	1.08e-01	0.155000	3.05e-01
Vitamin B5 (pantothenate) metabolism	20	2.31e-01	0.155000	4.68e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	3.53e-01	-0.155000	5.98e-01
RHO GTPase Effectors	258	1.88e-05	-0.155000	2.98e-04
Golgi Associated Vesicle Biogenesis	55	4.73e-02	-0.155000	1.79e-01
Regulation of PTEN gene transcription	59	4.05e-02	0.154000	1.63e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.31e-01	0.154000	3.42e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.31e-01	0.154000	3.42e-01
DNA Damage/Telomere Stress Induced Senescence	42	8.45e-02	-0.154000	2.60e-01
Heparan sulfate/heparin (HS-GAG) metabolism	40	9.25e-02	-0.154000	2.72e-01
ERBB2 Activates PTK6 Signaling	8	4.52e-01	-0.154000	6.75e-01
FCERI mediated NF-kB activation	129	2.57e-03	-0.154000	2.04e-02
VxPx cargo-targeting to cilium	19	2.47e-01	-0.154000	4.89e-01
Other interleukin signaling	19	2.47e-01	0.153000	4.89e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	4.18e-02	-0.153000	1.65e-01
Retrograde neurotrophin signalling	12	3.59e-01	-0.153000	6.00e-01
Fc epsilon receptor (FCERI) signaling	179	4.25e-04	-0.153000	4.43e-03
Glycosphingolipid metabolism	46	7.34e-02	-0.153000	2.37e-01
Signaling by NOTCH3	44	8.02e-02	-0.152000	2.52e-01
Transport of the SLBP independent Mature mRNA	35	1.19e-01	0.152000	3.23e-01
Formation of RNA Pol II elongation complex	56	4.86e-02	0.152000	1.81e-01
RNA Polymerase II Transcription Elongation	56	4.86e-02	0.152000	1.81e-01
Axonal growth inhibition (RHOA activation)	7	4.85e-01	-0.152000	6.99e-01
p75NTR regulates axonogenesis	7	4.85e-01	-0.152000	6.99e-01
C-type lectin receptors (CLRs)	118	4.27e-03	0.152000	3.00e-02
Protein methylation	15	3.07e-01	0.152000	5.59e-01
Biosynthesis of maresin-like SPMs	5	5.55e-01	0.152000	7.57e-01
IRAK1 recruits IKK complex	14	3.25e-01	-0.152000	5.74e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	3.25e-01	-0.152000	5.74e-01
Activation of kainate receptors upon glutamate binding	26	1.81e-01	-0.151000	4.07e-01
Phosphorylation of the APC/C	20	2.42e-01	0.151000	4.83e-01
CRMPs in Sema3A signaling	13	3.46e-01	-0.151000	5.95e-01
Smooth Muscle Contraction	34	1.29e-01	-0.150000	3.42e-01
Endosomal/Vacuolar pathway	12	3.69e-01	0.150000	6.07e-01
Signaling by PDGFRA extracellular domain mutants	12	3.69e-01	-0.150000	6.07e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.69e-01	-0.150000	6.07e-01
Diseases associated with glycosaminoglycan metabolism	25	1.95e-01	-0.150000	4.23e-01
Intrinsic Pathway of Fibrin Clot Formation	15	3.16e-01	-0.150000	5.65e-01
STING mediated induction of host immune responses	15	3.16e-01	0.150000	5.65e-01
Azathioprine ADME	21	2.36e-01	0.149000	4.74e-01
CDC6 association with the ORC:origin complex	8	4.65e-01	-0.149000	6.84e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	3.71e-01	0.149000	6.07e-01
Attachment and Entry 9694614	14	3.34e-01	0.149000	5.83e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	86	1.71e-02	-0.149000	8.87e-02
SUMOylation of RNA binding proteins	47	7.78e-02	0.149000	2.46e-01
Keratan sulfate/keratin metabolism	28	1.73e-01	-0.149000	3.97e-01
CD209 (DC-SIGN) signaling	20	2.51e-01	0.148000	4.94e-01
Recycling pathway of L1	40	1.05e-01	-0.148000	3.00e-01
MASTL Facilitates Mitotic Progression	10	4.18e-01	-0.148000	6.44e-01
Insulin receptor recycling	24	2.10e-01	-0.148000	4.38e-01
Late Phase of HIV Life Cycle	131	3.55e-03	0.148000	2.62e-02
Adrenaline,noradrenaline inhibits insulin secretion	24	2.11e-01	-0.147000	4.38e-01
Synthesis of 12-eicosatetraenoic acid derivatives	6	5.33e-01	-0.147000	7.41e-01
Prolactin receptor signaling	12	3.78e-01	0.147000	6.16e-01
GRB2 events in ERBB2 signaling	11	4.00e-01	-0.147000	6.29e-01
FOXO-mediated transcription of cell death genes	16	3.11e-01	-0.146000	5.60e-01
G0 and Early G1	27	1.89e-01	-0.146000	4.13e-01
RSV-host interactions	78	2.61e-02	0.146000	1.19e-01
Ethanol oxidation	8	4.77e-01	0.145000	6.94e-01
Signaling by FGFR1 in disease	32	1.58e-01	-0.144000	3.79e-01
G beta:gamma signalling through PI3Kgamma	22	2.42e-01	-0.144000	4.83e-01
Negative regulation of MET activity	18	2.91e-01	-0.144000	5.41e-01
Base Excision Repair	57	6.11e-02	0.143000	2.07e-01
SUMOylation of DNA methylation proteins	16	3.21e-01	0.143000	5.71e-01
Signaling by TGF-beta Receptor Complex	91	1.84e-02	-0.143000	9.38e-02
Peroxisomal protein import	58	5.97e-02	0.143000	2.06e-01
Repression of WNT target genes	14	3.55e-01	0.143000	5.98e-01
Detoxification of Reactive Oxygen Species	30	1.76e-01	0.143000	4.00e-01
Trafficking of GluR2-containing AMPA receptors	11	4.13e-01	-0.143000	6.41e-01
Ephrin signaling	18	2.96e-01	0.142000	5.46e-01
Lysosphingolipid and LPA receptors	11	4.15e-01	0.142000	6.42e-01
FOXO-mediated transcription	58	6.14e-02	-0.142000	2.07e-01
CDC42 GTPase cycle	141	3.62e-03	-0.142000	2.63e-02
Transport of fatty acids	5	5.83e-01	-0.142000	7.76e-01
HIV elongation arrest and recovery	32	1.66e-01	0.142000	3.89e-01
Pausing and recovery of HIV elongation	32	1.66e-01	0.142000	3.89e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	3.60e-01	-0.141000	6.00e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.22e-01	-0.141000	4.55e-01
Association of TriC/CCT with target proteins during biosynthesis	35	1.49e-01	0.141000	3.67e-01
Reversible hydration of carbon dioxide	8	4.91e-01	-0.141000	7.05e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	4.89e-02	0.140000	1.81e-01
Regulation of TLR by endogenous ligand	15	3.47e-01	0.140000	5.97e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	1.72e-01	0.139000	3.96e-01
Signaling by MAPK mutants	6	5.55e-01	0.139000	7.56e-01
FGFR2 alternative splicing	25	2.29e-01	0.139000	4.65e-01
Downstream signaling of activated FGFR4	18	3.08e-01	-0.139000	5.59e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	3.37e-01	0.139000	5.85e-01
Assembly of the pre-replicative complex	87	2.54e-02	0.139000	1.16e-01
SUMO is conjugated to E1 (UBA2:SAE1)	5	5.92e-01	0.138000	7.81e-01
Interleukin-7 signaling	21	2.73e-01	-0.138000	5.20e-01
Lewis blood group biosynthesis	14	3.73e-01	0.138000	6.10e-01
Signal transduction by L1	20	2.87e-01	-0.137000	5.36e-01
Apoptotic factor-mediated response	19	3.00e-01	0.137000	5.49e-01
Biosynthesis of EPA-derived SPMs	6	5.62e-01	-0.137000	7.61e-01
Integration of energy metabolism	88	2.70e-02	-0.136000	1.22e-01
Interleukin-1 signaling	99	1.90e-02	0.136000	9.57e-02
Peptide ligand-binding receptors	101	1.80e-02	-0.136000	9.25e-02
ATF4 activates genes in response to endoplasmic reticulum stress	25	2.39e-01	0.136000	4.80e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	1.19e-01	0.136000	3.23e-01
Defective GALNT12 causes CRCS1	9	4.81e-01	-0.136000	6.96e-01
Resolution of Sister Chromatid Cohesion	116	1.17e-02	-0.135000	6.81e-02
Interleukin-12 signaling	44	1.20e-01	0.135000	3.26e-01
Tryptophan catabolism	12	4.17e-01	0.135000	6.44e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	2.96e-01	-0.135000	5.46e-01
Trafficking of AMPA receptors	20	2.96e-01	-0.135000	5.46e-01
Fanconi Anemia Pathway	36	1.61e-01	0.135000	3.82e-01
Deadenylation-dependent mRNA decay	50	9.92e-02	0.135000	2.86e-01
G beta:gamma signalling through BTK	15	3.66e-01	-0.135000	6.04e-01
Metabolism of folate and pterines	16	3.51e-01	0.135000	5.98e-01
Cilium Assembly	186	1.53e-03	0.135000	1.31e-02
Glycine degradation	7	5.38e-01	0.134000	7.45e-01
Sema4D mediated inhibition of cell attachment and migration	7	5.38e-01	-0.134000	7.45e-01
PIWI-interacting RNA (piRNA) biogenesis	23	2.65e-01	0.134000	5.11e-01
Synthesis of PIPs at the early endosome membrane	16	3.53e-01	-0.134000	5.98e-01
Antiviral mechanism by IFN-stimulated genes	140	6.10e-03	0.134000	3.97e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	4.22e-01	0.134000	6.48e-01
Signaling by Hedgehog	120	1.13e-02	0.134000	6.61e-02
Acyl chain remodelling of PS	14	3.86e-01	0.134000	6.20e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	5.40e-01	0.134000	7.46e-01
Signaling by FGFR3 in disease	14	3.88e-01	-0.133000	6.20e-01
MECP2 regulates neuronal receptors and channels	14	3.90e-01	-0.133000	6.23e-01
Phospholipase C-mediated cascade; FGFR3	5	6.10e-01	0.132000	7.94e-01
G2/M Transition	177	2.49e-03	0.132000	1.99e-02
Organelle biogenesis and maintenance	277	1.60e-04	0.132000	1.91e-03
Signaling by BMP	23	2.75e-01	-0.132000	5.20e-01
Thromboxane signalling through TP receptor	20	3.10e-01	-0.131000	5.60e-01
TGF-beta receptor signaling activates SMADs	45	1.28e-01	-0.131000	3.40e-01
RIPK1-mediated regulated necrosis	31	2.08e-01	0.131000	4.38e-01
Regulation of necroptotic cell death	31	2.08e-01	0.131000	4.38e-01
Interleukin-6 signaling	11	4.54e-01	-0.130000	6.77e-01
RND3 GTPase cycle	36	1.76e-01	-0.130000	4.00e-01
Activation of RAS in B cells	5	6.14e-01	0.130000	7.97e-01
S Phase	150	5.95e-03	0.130000	3.94e-02
Formation of the Editosome	6	5.81e-01	-0.130000	7.75e-01
mRNA Editing: C to U Conversion	6	5.81e-01	-0.130000	7.75e-01
PI3K events in ERBB4 signaling	6	5.81e-01	-0.130000	7.75e-01
Post-chaperonin tubulin folding pathway	18	3.43e-01	-0.129000	5.92e-01
RNA Polymerase III Chain Elongation	18	3.44e-01	0.129000	5.93e-01
Meiotic synapsis	43	1.45e-01	-0.128000	3.62e-01
Peroxisomal lipid metabolism	27	2.48e-01	0.128000	4.91e-01
Keratinization	37	1.77e-01	-0.128000	4.01e-01
Early SARS-CoV-2 Infection Events	31	2.16e-01	0.128000	4.47e-01
Inactivation, recovery and regulation of the phototransduction cascade	25	2.67e-01	-0.128000	5.14e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	2.41e-01	0.128000	4.83e-01
FGFR1b ligand binding and activation	5	6.21e-01	-0.128000	7.98e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.47e-01	0.128000	3.64e-01
Cellular hexose transport	14	4.09e-01	0.127000	6.40e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	5.09e-01	-0.127000	7.18e-01
AKT phosphorylates targets in the cytosol	14	4.10e-01	-0.127000	6.40e-01
RND2 GTPase cycle	37	1.82e-01	-0.127000	4.07e-01
Glycosphingolipid biosynthesis	15	3.95e-01	-0.127000	6.26e-01
PI Metabolism	79	5.21e-02	-0.126000	1.88e-01
MET activates PTK2 signaling	23	2.94e-01	-0.126000	5.46e-01
Centrosome maturation	81	4.98e-02	0.126000	1.82e-01
Recruitment of mitotic centrosome proteins and complexes	81	4.98e-02	0.126000	1.82e-01
Incretin synthesis, secretion, and inactivation	14	4.15e-01	0.126000	6.42e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	4.15e-01	0.126000	6.42e-01
Downstream signal transduction	27	2.58e-01	-0.126000	5.00e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	79	5.34e-02	-0.126000	1.91e-01
O-linked glycosylation of mucins	47	1.36e-01	-0.126000	3.48e-01
Pre-NOTCH Processing in Golgi	18	3.56e-01	-0.126000	5.99e-01
Signaling by ALK	24	2.87e-01	0.126000	5.36e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	1.61e-01	0.125000	3.82e-01
MicroRNA (miRNA) biogenesis	24	2.89e-01	0.125000	5.39e-01
Molecules associated with elastic fibres	26	2.71e-01	-0.125000	5.19e-01
SARS-CoV-2 Infection	267	4.63e-04	0.124000	4.79e-03
Extra-nuclear estrogen signaling	67	7.81e-02	-0.124000	2.47e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	4.21e-01	-0.124000	6.47e-01
SUMOylation of DNA damage response and repair proteins	77	5.96e-02	0.124000	2.06e-01
Maturation of hRSV A proteins	13	4.39e-01	-0.124000	6.63e-01
Regulation of PLK1 Activity at G2/M Transition	87	4.56e-02	0.124000	1.75e-01
Transmission across Chemical Synapses	188	3.44e-03	-0.124000	2.60e-02
Potential therapeutics for SARS	149	9.20e-03	-0.124000	5.50e-02
RHO GTPases Activate WASPs and WAVEs	35	2.06e-01	-0.124000	4.37e-01
Signaling by FGFR3	32	2.27e-01	-0.124000	4.62e-01
Mitochondrial biogenesis	91	4.17e-02	0.124000	1.65e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	4.99e-01	-0.123000	7.12e-01
DNA Replication	128	1.59e-02	0.123000	8.44e-02
Myogenesis	21	3.27e-01	-0.123000	5.76e-01
TP53 Regulates Transcription of DNA Repair Genes	61	9.62e-02	0.123000	2.80e-01
NR1H2 and NR1H3-mediated signaling	39	1.84e-01	0.123000	4.09e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	9.45e-02	-0.123000	2.77e-01
EML4 and NUDC in mitotic spindle formation	107	2.84e-02	-0.123000	1.26e-01
Eicosanoids	6	6.04e-01	-0.122000	7.90e-01
Activation of BH3-only proteins	30	2.46e-01	-0.122000	4.89e-01
Hydrolysis of LPC	8	5.49e-01	-0.122000	7.54e-01
Synthesis of 15-eicosatetraenoic acid derivatives	6	6.05e-01	-0.122000	7.90e-01
Sulfur amino acid metabolism	23	3.13e-01	0.122000	5.62e-01
Type I hemidesmosome assembly	8	5.52e-01	0.122000	7.54e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	6.07e-01	-0.121000	7.92e-01
TGFBR1 KD Mutants in Cancer	6	6.07e-01	-0.121000	7.92e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	3.25e-01	-0.121000	5.74e-01
Phase 4 - resting membrane potential	9	5.29e-01	0.121000	7.37e-01
Signaling by the B Cell Receptor (BCR)	150	1.05e-02	-0.121000	6.19e-02
SUMOylation of chromatin organization proteins	57	1.14e-01	0.121000	3.16e-01
Transcription of the HIV genome	67	8.71e-02	0.121000	2.62e-01
Mitotic G2-G2/M phases	179	5.38e-03	0.121000	3.63e-02
Toxicity of botulinum toxin type D (botD)	5	6.41e-01	0.120000	8.09e-01
Toxicity of botulinum toxin type F (botF)	5	6.41e-01	0.120000	8.09e-01
Recycling of bile acids and salts	10	5.10e-01	0.120000	7.19e-01
SHC-related events triggered by IGF1R	8	5.56e-01	-0.120000	7.57e-01
Signaling by NTRK2 (TRKB)	20	3.53e-01	-0.120000	5.98e-01
Transcriptional regulation by RUNX3	81	6.18e-02	0.120000	2.08e-01
ABC transporters in lipid homeostasis	14	4.37e-01	0.120000	6.62e-01
Cell recruitment (pro-inflammatory response)	25	3.00e-01	0.120000	5.49e-01
Purinergic signaling in leishmaniasis infection	25	3.00e-01	0.120000	5.49e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	3.42e-01	0.120000	5.91e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	3.42e-01	0.120000	5.91e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	3.54e-01	0.120000	5.98e-01
Biosynthesis of maresins	7	5.84e-01	0.119000	7.76e-01
RAB GEFs exchange GTP for GDP on RABs	89	5.21e-02	-0.119000	1.88e-01
Nuclear Receptor transcription pathway	40	1.93e-01	0.119000	4.20e-01
NrCAM interactions	6	6.14e-01	0.119000	7.97e-01
Transcriptional regulation by RUNX2	92	4.89e-02	0.119000	1.81e-01
FGFR2b ligand binding and activation	6	6.15e-01	-0.119000	7.97e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	5.38e-01	-0.119000	7.45e-01
Fatty acyl-CoA biosynthesis	35	2.27e-01	-0.118000	4.62e-01
FGFR1 ligand binding and activation	10	5.18e-01	-0.118000	7.28e-01
Interleukin-23 signaling	7	5.89e-01	0.118000	7.79e-01
RHOA GTPase cycle	139	1.65e-02	-0.118000	8.63e-02
Activation of NOXA and translocation to mitochondria	5	6.48e-01	0.118000	8.11e-01
Ca2+ pathway	58	1.21e-01	-0.118000	3.27e-01
Mitotic Telophase/Cytokinesis	13	4.63e-01	-0.118000	6.84e-01
Vesicle-mediated transport	669	2.19e-07	-0.117000	5.29e-06
Paracetamol ADME	19	3.77e-01	0.117000	6.15e-01
DNA Replication Pre-Initiation	103	4.02e-02	0.117000	1.62e-01
RET signaling	32	2.53e-01	-0.117000	4.96e-01
Formation of tubulin folding intermediates by CCT/TriC	21	3.55e-01	0.117000	5.98e-01
IRAK2 mediated activation of TAK1 complex	10	5.23e-01	0.117000	7.31e-01
RHOBTB1 GTPase cycle	23	3.33e-01	0.117000	5.82e-01
Transport and synthesis of PAPS	6	6.23e-01	-0.116000	8.00e-01
Regulation of PTEN mRNA translation	13	4.69e-01	-0.116000	6.89e-01
DNA replication initiation	8	5.70e-01	0.116000	7.69e-01
Cellular responses to mechanical stimuli	82	7.00e-02	-0.116000	2.29e-01
Response of endothelial cells to shear stress	82	7.00e-02	-0.116000	2.29e-01
APC-Cdc20 mediated degradation of Nek2A	26	3.07e-01	0.116000	5.59e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	19	3.85e-01	-0.115000	6.20e-01
Platelet sensitization by LDL	16	4.26e-01	-0.115000	6.52e-01
Erythropoietin activates Phospholipase C gamma (PLCG)	6	6.26e-01	-0.115000	8.03e-01
Apoptosis induced DNA fragmentation	10	5.30e-01	-0.115000	7.38e-01
Signaling by BRAF and RAF1 fusions	60	1.25e-01	-0.114000	3.33e-01
Gastrulation	76	8.59e-02	0.114000	2.61e-01
Negative regulation of FGFR3 signaling	21	3.66e-01	-0.114000	6.04e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	3.33e-02	-0.114000	1.41e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	6.05e-02	-0.114000	2.06e-01
Amplification of signal from the kinetochores	91	6.05e-02	-0.114000	2.06e-01
Respiratory Syncytial Virus Infection Pathway	99	5.04e-02	0.114000	1.83e-01
Activated point mutants of FGFR2	7	6.03e-01	0.114000	7.89e-01
Regulation of NFE2L2 gene expression	8	5.78e-01	-0.114000	7.74e-01
Nectin/Necl trans heterodimerization	5	6.60e-01	-0.114000	8.21e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	4.18e-01	0.113000	6.44e-01
Downstream signaling of activated FGFR2	20	3.81e-01	-0.113000	6.18e-01
Senescence-Associated Secretory Phenotype (SASP)	65	1.15e-01	-0.113000	3.16e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	2.11e-01	-0.113000	4.38e-01
RHOBTB GTPase Cycle	35	2.49e-01	0.113000	4.92e-01
FGFR4 ligand binding and activation	5	6.63e-01	0.113000	8.23e-01
Acyl chain remodelling of PI	10	5.39e-01	-0.112000	7.45e-01
Signaling by ERBB2 ECD mutants	15	4.54e-01	-0.112000	6.76e-01
Drug ADME	59	1.38e-01	0.112000	3.51e-01
O-glycosylation of TSR domain-containing proteins	28	3.08e-01	-0.111000	5.59e-01
Viral Infection Pathways	776	1.35e-07	0.111000	3.38e-06
IKK complex recruitment mediated by RIP1	23	3.56e-01	0.111000	5.99e-01
Signaling by SCF-KIT	40	2.24e-01	-0.111000	4.57e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.00e-01	0.111000	2.87e-01
Chemokine receptors bind chemokines	39	2.32e-01	-0.111000	4.71e-01
L1CAM interactions	100	5.62e-02	-0.110000	1.98e-01
Signaling by high-kinase activity BRAF mutants	33	2.72e-01	-0.110000	5.19e-01
RUNX2 regulates genes involved in cell migration	6	6.40e-01	-0.110000	8.09e-01
RAC3 GTPase cycle	88	7.43e-02	-0.110000	2.39e-01
Signaling by FLT3 fusion proteins	18	4.19e-01	0.110000	6.45e-01
VEGFR2 mediated vascular permeability	26	3.32e-01	0.110000	5.82e-01
Synthesis of bile acids and bile salts	27	3.24e-01	-0.110000	5.73e-01
Fatty acids	6	6.42e-01	0.110000	8.09e-01
Metabolic disorders of biological oxidation enzymes	26	3.33e-01	-0.110000	5.82e-01
Rap1 signalling	14	4.78e-01	-0.110000	6.94e-01
Kinesins	51	1.77e-01	-0.109000	4.01e-01
Signaling by TGFB family members	139	2.62e-02	-0.109000	1.19e-01
NRIF signals cell death from the nucleus	15	4.65e-01	-0.109000	6.84e-01
SUMOylation of DNA replication proteins	46	2.01e-01	0.109000	4.31e-01
Arachidonate metabolism	45	2.07e-01	-0.109000	4.38e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	4.98e-01	-0.108000	7.12e-01
Retinoid metabolism and transport	25	3.48e-01	-0.108000	5.97e-01
Neurexins and neuroligins	40	2.36e-01	0.108000	4.74e-01
Signaling by RAF1 mutants	37	2.55e-01	-0.108000	4.97e-01
AKT phosphorylates targets in the nucleus	9	5.74e-01	0.108000	7.71e-01
Diseases of branched-chain amino acid catabolism	13	5.00e-01	0.108000	7.13e-01
Gap junction assembly	17	4.43e-01	-0.107000	6.67e-01
Collagen chain trimerization	29	3.18e-01	-0.107000	5.67e-01
Prevention of phagosomal-lysosomal fusion	9	5.80e-01	0.107000	7.75e-01
Triglyceride catabolism	16	4.60e-01	-0.107000	6.83e-01
Purine catabolism	16	4.61e-01	0.106000	6.83e-01
Synthesis of PIPs at the ER membrane	5	6.80e-01	-0.106000	8.31e-01
Pyrimidine catabolism	9	5.81e-01	-0.106000	7.75e-01
Transcriptional Regulation by NPAS4	27	3.39e-01	-0.106000	5.88e-01
SMAC (DIABLO) binds to IAPs	7	6.27e-01	0.106000	8.03e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	6.27e-01	0.106000	8.03e-01
SMAC, XIAP-regulated apoptotic response	7	6.27e-01	0.106000	8.03e-01
Integrin cell surface interactions	68	1.31e-01	-0.106000	3.42e-01
Cellular responses to stress	698	1.92e-06	0.106000	3.98e-05
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	3.83e-01	-0.105000	6.20e-01
Translation of Structural Proteins 9694635	56	1.74e-01	-0.105000	3.97e-01
Interleukin-2 signaling	11	5.47e-01	0.105000	7.53e-01
RHO GTPases activate CIT	18	4.42e-01	-0.105000	6.67e-01
Signaling by FGFR4	32	3.07e-01	-0.104000	5.59e-01
Inactivation of CSF3 (G-CSF) signaling	24	3.77e-01	0.104000	6.15e-01
Gap junction trafficking	28	3.41e-01	-0.104000	5.91e-01
Cation-coupled Chloride cotransporters	6	6.60e-01	0.104000	8.21e-01
Adenylate cyclase activating pathway	8	6.11e-01	-0.104000	7.95e-01
EPH-Ephrin signaling	81	1.06e-01	-0.104000	3.02e-01
Killing mechanisms	9	5.91e-01	0.103000	7.81e-01
WNT5:FZD7-mediated leishmania damping	9	5.91e-01	0.103000	7.81e-01
Defective B3GALTL causes PpS	27	3.53e-01	-0.103000	5.98e-01
Phospholipid metabolism	183	1.62e-02	-0.103000	8.54e-02
Regulation of pyruvate dehydrogenase (PDH) complex	14	5.04e-01	0.103000	7.15e-01
Late SARS-CoV-2 Infection Events	64	1.56e-01	-0.103000	3.76e-01
RNA Polymerase III Transcription Initiation	36	2.90e-01	0.102000	5.39e-01
Biosynthesis of specialized proresolving mediators (SPMs)	17	4.70e-01	-0.101000	6.89e-01
NGF-stimulated transcription	32	3.22e-01	0.101000	5.72e-01
Spry regulation of FGF signaling	16	4.84e-01	-0.101000	6.99e-01
Signaling by RNF43 mutants	7	6.43e-01	-0.101000	8.09e-01
Lipophagy	7	6.43e-01	-0.101000	8.09e-01
RNA polymerase II transcribes snRNA genes	71	1.43e-01	0.101000	3.58e-01
Factors involved in megakaryocyte development and platelet production	129	4.84e-02	-0.101000	1.81e-01
FRS-mediated FGFR4 signaling	13	5.30e-01	-0.100000	7.38e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	6.71e-01	-0.100000	8.27e-01
Glycogen metabolism	21	4.28e-01	-0.099800	6.55e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	4.40e-01	0.099800	6.65e-01
Oxidative Stress Induced Senescence	77	1.31e-01	-0.099600	3.42e-01
P2Y receptors	10	5.86e-01	0.099600	7.77e-01
Dissolution of Fibrin Clot	12	5.51e-01	0.099400	7.54e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	2.15e-01	0.099400	4.45e-01
G2/M DNA damage checkpoint	66	1.63e-01	-0.099300	3.85e-01
Loss of Nlp from mitotic centrosomes	69	1.54e-01	0.099200	3.75e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	1.54e-01	0.099200	3.75e-01
Synthesis of substrates in N-glycan biosythesis	59	1.88e-01	0.099000	4.12e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	5.88e-01	0.099000	7.79e-01
Negative regulation of FLT3	15	5.08e-01	0.098800	7.17e-01
IRF3-mediated induction of type I IFN	12	5.55e-01	0.098500	7.56e-01
Linoleic acid (LA) metabolism	7	6.52e-01	0.098500	8.14e-01
N-glycan trimming and elongation in the cis-Golgi	5	7.03e-01	-0.098400	8.43e-01
tRNA processing	128	5.47e-02	0.098300	1.94e-01
Gap junction degradation	11	5.72e-01	-0.098300	7.70e-01
Erythropoietin activates STAT5	6	6.77e-01	0.098200	8.31e-01
B-WICH complex positively regulates rRNA expression	45	2.55e-01	-0.098000	4.97e-01
Transport to the Golgi and subsequent modification	171	2.70e-02	-0.098000	1.22e-01
Fructose catabolism	5	7.05e-01	0.097900	8.43e-01
Metabolism of cofactors	25	3.97e-01	0.097800	6.26e-01
G alpha (q) signalling events	139	4.68e-02	-0.097700	1.78e-01
G alpha (i) signalling events	194	1.90e-02	-0.097600	9.57e-02
DNA Repair	289	4.37e-03	0.097400	3.04e-02
TNF signaling	56	2.09e-01	0.097100	4.38e-01
Regulation of insulin secretion	63	1.83e-01	-0.097100	4.07e-01
Initiation of Nuclear Envelope (NE) Reformation	19	4.64e-01	-0.097100	6.84e-01
G1/S Transition	120	6.63e-02	0.097000	2.21e-01
PERK regulates gene expression	30	3.58e-01	0.097000	6.00e-01
ERBB2 Regulates Cell Motility	10	5.98e-01	-0.096400	7.86e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	1.67e-01	0.096300	3.89e-01
Infection with Mycobacterium tuberculosis	26	3.95e-01	-0.096300	6.26e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	6.60e-01	0.096200	8.21e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	4.81e-01	0.096000	6.96e-01
Pentose phosphate pathway	13	5.50e-01	-0.095700	7.54e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	4.71e-01	-0.095600	6.89e-01
Degradation of cysteine and homocysteine	13	5.52e-01	0.095400	7.54e-01
Clathrin-mediated endocytosis	128	6.26e-02	-0.095300	2.09e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	4.10e-01	-0.095300	6.40e-01
Phospholipase C-mediated cascade: FGFR1	8	6.43e-01	-0.094700	8.09e-01
Intra-Golgi traffic	43	2.83e-01	-0.094600	5.31e-01
Disorders of transmembrane transporters	137	5.60e-02	0.094600	1.97e-01
Activation of HOX genes during differentiation	70	1.72e-01	-0.094500	3.96e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	1.72e-01	-0.094500	3.96e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	624	5.64e-05	-0.094400	7.90e-04
Blood group systems biosynthesis	18	4.88e-01	0.094300	7.03e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	5.16e-01	-0.093800	7.26e-01
Glutathione conjugation	28	3.91e-01	0.093700	6.24e-01
Regulation of NF-kappa B signaling	18	4.92e-01	0.093600	7.06e-01
RMTs methylate histone arginines	35	3.38e-01	0.093600	5.87e-01
Processing and activation of SUMO	10	6.09e-01	0.093400	7.94e-01
Meiosis	67	1.86e-01	-0.093400	4.10e-01
Signaling by FGFR2 in disease	33	3.53e-01	0.093300	5.98e-01
Elastic fibre formation	33	3.54e-01	-0.093200	5.98e-01
Gap junction trafficking and regulation	30	3.77e-01	-0.093100	6.15e-01
Glutamate and glutamine metabolism	12	5.77e-01	-0.092900	7.74e-01
Diseases associated with N-glycosylation of proteins	20	4.72e-01	0.092900	6.90e-01
Growth hormone receptor signaling	21	4.61e-01	-0.092900	6.83e-01
Termination of O-glycan biosynthesis	16	5.20e-01	-0.092900	7.29e-01
Signaling by cytosolic FGFR1 fusion mutants	18	4.96e-01	-0.092700	7.10e-01
trans-Golgi Network Vesicle Budding	69	1.83e-01	-0.092600	4.08e-01
Metabolism of fat-soluble vitamins	28	3.97e-01	-0.092400	6.26e-01
Dopamine Neurotransmitter Release Cycle	20	4.77e-01	0.091800	6.94e-01
Sodium-coupled phosphate cotransporters	5	7.22e-01	-0.091800	8.52e-01
Prostacyclin signalling through prostacyclin receptor	16	5.25e-01	-0.091800	7.32e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	7.24e-01	-0.091000	8.53e-01
O-linked glycosylation	85	1.47e-01	-0.091000	3.64e-01
VEGFA-VEGFR2 Pathway	93	1.29e-01	-0.091000	3.42e-01
Josephin domain DUBs	10	6.19e-01	0.090800	7.98e-01
PI3K/AKT Signaling in Cancer	85	1.48e-01	-0.090800	3.66e-01
Ca2+ activated K+ channels	6	7.01e-01	-0.090400	8.43e-01
LGI-ADAM interactions	9	6.39e-01	0.090400	8.09e-01
WNT ligand biogenesis and trafficking	19	4.96e-01	0.090200	7.10e-01
Nuclear Pore Complex (NPC) Disassembly	36	3.51e-01	0.089900	5.98e-01
Signaling by Rho GTPases	608	1.55e-04	-0.089800	1.87e-03
RUNX3 Regulates Immune Response and Cell Migration	6	7.04e-01	-0.089700	8.43e-01
TGFBR3 regulates TGF-beta signaling	8	6.61e-01	0.089600	8.21e-01
SUMO E3 ligases SUMOylate target proteins	161	5.00e-02	0.089500	1.82e-01
Glyoxylate metabolism and glycine degradation	13	5.77e-01	0.089400	7.73e-01
Metal ion SLC transporters	19	5.01e-01	-0.089300	7.13e-01
Glutamate Neurotransmitter Release Cycle	20	4.91e-01	0.089000	7.05e-01
IRAK4 deficiency (TLR2/4)	15	5.51e-01	-0.088900	7.54e-01
The phototransduction cascade	26	4.34e-01	-0.088600	6.58e-01
Zygotic genome activation (ZGA)	5	7.32e-01	-0.088600	8.60e-01
RAF-independent MAPK1/3 activation	22	4.73e-01	-0.088300	6.91e-01
Rab regulation of trafficking	122	9.21e-02	-0.088300	2.72e-01
Innate Immune System	971	3.17e-06	-0.088300	6.25e-05
Regulation of TNFR1 signaling	47	2.96e-01	0.088200	5.46e-01
PDH complex synthesizes acetyl-CoA from PYR	5	7.34e-01	0.087800	8.62e-01
Plasma lipoprotein clearance	33	3.84e-01	0.087700	6.20e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	4.31e-01	-0.087600	6.57e-01
Metabolism	1835	5.08e-10	0.087500	1.49e-08
FGFR1c ligand binding and activation	8	6.70e-01	-0.086900	8.26e-01
Glycerophospholipid biosynthesis	105	1.25e-01	-0.086700	3.33e-01
Defective LFNG causes SCDO3	5	7.38e-01	0.086500	8.64e-01
E2F mediated regulation of DNA replication	22	4.82e-01	-0.086500	6.98e-01
G-protein activation	19	5.14e-01	-0.086400	7.25e-01
Vitamin B1 (thiamin) metabolism	5	7.38e-01	-0.086200	8.64e-01
HDMs demethylate histones	22	4.84e-01	-0.086100	6.99e-01
Activated NTRK3 signals through RAS	7	6.95e-01	-0.085700	8.40e-01
Nonhomologous End-Joining (NHEJ)	40	3.49e-01	-0.085500	5.98e-01
Metabolism of proteins	1777	2.11e-09	0.085500	5.90e-08
MAPK targets/ Nuclear events mediated by MAP kinases	31	4.10e-01	-0.085500	6.40e-01
GPVI-mediated activation cascade	33	3.97e-01	-0.085200	6.26e-01
Post-translational modification: synthesis of GPI-anchored proteins	59	2.58e-01	0.085100	5.00e-01
SUMOylation	167	5.81e-02	0.085000	2.03e-01
Induction of Cell-Cell Fusion	8	6.78e-01	-0.084700	8.31e-01
RAC2 GTPase cycle	86	1.75e-01	-0.084600	3.99e-01
Telomere Maintenance	78	1.97e-01	0.084400	4.26e-01
RHO GTPases Activate Formins	128	9.98e-02	-0.084200	2.86e-01
RORA activates gene expression	18	5.38e-01	-0.083900	7.45e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	1.32e-01	0.083800	3.42e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	5.38e-01	0.083700	7.45e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	5.90e-01	0.083300	7.80e-01
Iron uptake and transport	52	3.00e-01	0.083100	5.49e-01
Activation of RAC1 downstream of NMDARs	7	7.04e-01	-0.083000	8.43e-01
Anchoring of the basal body to the plasma membrane	97	1.60e-01	0.082500	3.82e-01
cGMP effects	12	6.21e-01	-0.082500	7.98e-01
ESR-mediated signaling	160	7.19e-02	-0.082400	2.33e-01
Neuronal System	276	1.85e-02	-0.082300	9.41e-02
Transcriptional Regulation by E2F6	34	4.06e-01	-0.082300	6.36e-01
Cargo concentration in the ER	31	4.28e-01	-0.082200	6.55e-01
Signaling by FGFR1	42	3.57e-01	-0.082200	5.99e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	4.78e-01	-0.082000	6.94e-01
Diseases associated with glycosylation precursor biosynthesis	15	5.84e-01	0.081600	7.76e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	3.66e-01	-0.081600	6.04e-01
Signaling by RAS mutants	41	3.66e-01	-0.081600	6.04e-01
Signaling by moderate kinase activity BRAF mutants	41	3.66e-01	-0.081600	6.04e-01
Signaling downstream of RAS mutants	41	3.66e-01	-0.081600	6.04e-01
Endogenous sterols	18	5.50e-01	0.081500	7.54e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	81	2.06e-01	-0.081200	4.37e-01
Bile acid and bile salt metabolism	31	4.34e-01	-0.081200	6.58e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	5.40e-01	0.081200	7.46e-01
RHO GTPases Activate NADPH Oxidases	21	5.20e-01	-0.081000	7.29e-01
Signaling by Receptor Tyrosine Kinases	449	3.28e-03	-0.080900	2.52e-02
RAC1 GTPase cycle	173	6.65e-02	-0.080900	2.21e-01
Metabolism of water-soluble vitamins and cofactors	115	1.34e-01	0.080800	3.46e-01
activated TAK1 mediates p38 MAPK activation	23	5.02e-01	-0.080800	7.13e-01
Signaling by ERBB2 in Cancer	21	5.22e-01	-0.080700	7.29e-01
TAK1-dependent IKK and NF-kappa-B activation	43	3.61e-01	0.080600	6.01e-01
Regulation of gene expression in beta cells	8	6.95e-01	-0.080100	8.40e-01
RHO GTPases Activate Rhotekin and Rhophilins	8	6.95e-01	-0.080100	8.40e-01
Constitutive Signaling by Overexpressed ERBB2	11	6.46e-01	-0.080000	8.10e-01
Synthesis of very long-chain fatty acyl-CoAs	22	5.16e-01	-0.080000	7.26e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.46e-01	-0.079900	8.10e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	5.00e-01	-0.079500	7.13e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.08e-01	-0.079400	5.59e-01
Signaling by NTRK3 (TRKC)	16	5.83e-01	0.079300	7.76e-01
Aspirin ADME	16	5.83e-01	-0.079300	7.76e-01
Transcription of E2F targets under negative control by DREAM complex	19	5.50e-01	-0.079200	7.54e-01
Reversal of alkylation damage by DNA dioxygenases	7	7.17e-01	-0.079200	8.48e-01
Cholesterol biosynthesis	26	4.85e-01	0.079100	6.99e-01
Constitutive Signaling by Aberrant PI3K in Cancer	59	2.94e-01	-0.078900	5.46e-01
Diseases of mitotic cell cycle	38	4.00e-01	0.078900	6.29e-01
Synthesis of PG	8	6.99e-01	0.078900	8.42e-01
G beta:gamma signalling through CDC42	17	5.74e-01	-0.078800	7.71e-01
Interleukin-4 and Interleukin-13 signaling	93	1.89e-01	-0.078800	4.13e-01
Transcriptional regulation of brown and beige adipocyte differentiation	24	5.05e-01	0.078700	7.15e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	24	5.05e-01	0.078700	7.15e-01
NOTCH1 Intracellular Domain Regulates Transcription	46	3.57e-01	0.078500	5.99e-01
Metabolism of Angiotensinogen to Angiotensins	12	6.38e-01	-0.078500	8.08e-01
TBC/RABGAPs	45	3.64e-01	-0.078200	6.04e-01
FGFR2c ligand binding and activation	5	7.62e-01	0.078200	8.76e-01
Cellular responses to stimuli	779	2.15e-04	0.077900	2.47e-03
Carboxyterminal post-translational modifications of tubulin	34	4.32e-01	-0.077900	6.57e-01
Fatty acid metabolism	155	9.63e-02	0.077400	2.80e-01
Interleukin-12 family signaling	53	3.30e-01	0.077300	5.80e-01
Activation of NMDA receptors and postsynaptic events	74	2.51e-01	-0.077200	4.94e-01
PI5P Regulates TP53 Acetylation	8	7.06e-01	0.077100	8.44e-01
Synthesis of Ketone Bodies	6	7.44e-01	0.077000	8.66e-01
ER Quality Control Compartment (ERQC)	21	5.42e-01	-0.076900	7.47e-01
Branched-chain amino acid catabolism	21	5.42e-01	0.076900	7.47e-01
Regulation of FZD by ubiquitination	16	5.96e-01	0.076500	7.84e-01
Formation of annular gap junctions	10	6.76e-01	-0.076400	8.31e-01
Intrinsic Pathway for Apoptosis	54	3.34e-01	-0.076100	5.82e-01
TRAF3-dependent IRF activation pathway	13	6.35e-01	0.075900	8.08e-01
Synthesis of PIPs at the Golgi membrane	16	5.99e-01	-0.075900	7.86e-01
Transcriptional Regulation by MECP2	49	3.59e-01	-0.075700	6.00e-01
Cardiogenesis	16	6.00e-01	0.075700	7.87e-01
Visual phototransduction	60	3.11e-01	-0.075600	5.60e-01
Insulin processing	19	5.69e-01	-0.075500	7.67e-01
Oncogene Induced Senescence	33	4.54e-01	-0.075400	6.76e-01
SLC-mediated transmembrane transport	175	8.67e-02	-0.075100	2.61e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	5.00e-01	-0.075000	7.13e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	6.82e-01	0.074900	8.31e-01
Sensory Perception	197	7.01e-02	-0.074800	2.29e-01
Signaling by FGFR4 in disease	11	6.68e-01	-0.074800	8.25e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	3.61e-01	-0.074600	6.01e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	5.95e-01	-0.074400	7.84e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	5.95e-01	-0.074400	7.84e-01
Inhibition of DNA recombination at telomere	33	4.61e-01	-0.074100	6.83e-01
Sialic acid metabolism	28	4.98e-01	0.074000	7.12e-01
Post-translational protein phosphorylation	70	2.86e-01	-0.073800	5.35e-01
MAP kinase activation	63	3.11e-01	-0.073800	5.60e-01
LDL clearance	18	5.88e-01	-0.073700	7.79e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	5.01e-01	0.073500	7.13e-01
Golgi-to-ER retrograde transport	123	1.60e-01	-0.073400	3.82e-01
Heme signaling	45	3.94e-01	-0.073400	6.26e-01
Constitutive Signaling by EGFRvIII	14	6.36e-01	-0.073100	8.08e-01
Signaling by EGFRvIII in Cancer	14	6.36e-01	-0.073100	8.08e-01
Signaling by Non-Receptor Tyrosine Kinases	47	3.86e-01	-0.073100	6.20e-01
Signaling by PTK6	47	3.86e-01	-0.073100	6.20e-01
ADP signalling through P2Y purinoceptor 1	21	5.63e-01	-0.072900	7.62e-01
Oncogenic MAPK signaling	76	2.72e-01	-0.072900	5.19e-01
EPHA-mediated growth cone collapse	21	5.64e-01	-0.072800	7.62e-01
mRNA Editing	8	7.23e-01	0.072500	8.52e-01
Negative regulation of FGFR4 signaling	22	5.58e-01	-0.072200	7.57e-01
Signaling by LTK	10	6.93e-01	-0.072100	8.40e-01
SUMOylation of ubiquitinylation proteins	39	4.37e-01	0.071900	6.62e-01
Signaling by ERBB2	44	4.11e-01	-0.071600	6.40e-01
FRS-mediated FGFR2 signaling	15	6.31e-01	-0.071600	8.06e-01
NCAM1 interactions	27	5.20e-01	0.071600	7.29e-01
Collagen biosynthesis and modifying enzymes	48	3.92e-01	-0.071500	6.24e-01
Programmed Cell Death	187	9.22e-02	0.071400	2.72e-01
Diseases of carbohydrate metabolism	29	5.06e-01	-0.071400	7.16e-01
RHO GTPases activate KTN1	11	6.82e-01	0.071300	8.31e-01
RHOH GTPase cycle	34	4.73e-01	-0.071200	6.90e-01
Signaling by TGFBR3	39	4.43e-01	-0.070900	6.67e-01
RNA Polymerase III Abortive And Retractive Initiation	41	4.32e-01	0.070900	6.57e-01
RNA Polymerase III Transcription	41	4.32e-01	0.070900	6.57e-01
Nervous system development	478	7.94e-03	0.070900	4.85e-02
AURKA Activation by TPX2	72	2.99e-01	0.070900	5.49e-01
Scavenging by Class A Receptors	14	6.46e-01	0.070800	8.10e-01
MyD88 deficiency (TLR2/4)	14	6.49e-01	-0.070300	8.11e-01
Nuclear events mediated by NFE2L2	82	2.73e-01	0.070000	5.20e-01
ROBO receptors bind AKAP5	7	7.49e-01	0.069900	8.68e-01
Transcriptional regulation by RUNX1	170	1.17e-01	-0.069600	3.21e-01
Nef Mediated CD4 Down-regulation	9	7.19e-01	0.069200	8.49e-01
Recruitment of NuMA to mitotic centrosomes	88	2.62e-01	0.069100	5.08e-01
Axon guidance	459	1.12e-02	0.069100	6.57e-02
COPI-mediated anterograde transport	92	2.55e-01	-0.068700	4.97e-01
Mitotic G1 phase and G1/S transition	138	1.63e-01	0.068700	3.85e-01
Reproduction	85	2.74e-01	-0.068700	5.20e-01
Membrane Trafficking	577	4.92e-03	-0.068500	3.37e-02
Deactivation of the beta-catenin transactivating complex	36	4.77e-01	0.068400	6.94e-01
Plasma lipoprotein assembly	10	7.08e-01	-0.068400	8.44e-01
Potassium Channels	64	3.45e-01	-0.068300	5.93e-01
MAP2K and MAPK activation	36	4.78e-01	-0.068300	6.94e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	6.70e-01	-0.068300	8.26e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	4.33e-01	-0.068300	6.58e-01
Synthesis of GDP-mannose	6	7.73e-01	0.068100	8.83e-01
Nuclear Events (kinase and transcription factor activation)	54	3.87e-01	0.068100	6.20e-01
RNA Polymerase I Promoter Escape	45	4.31e-01	-0.067900	6.57e-01
RNA Polymerase III Transcription Termination	23	5.74e-01	0.067700	7.71e-01
Cytokine Signaling in Immune system	670	2.88e-03	0.067500	2.25e-02
Phase I - Functionalization of compounds	70	3.29e-01	0.067500	5.78e-01
Cargo recognition for clathrin-mediated endocytosis	89	2.74e-01	-0.067100	5.20e-01
Signaling by ERBB2 TMD/JMD mutants	17	6.32e-01	0.067000	8.06e-01
IRE1alpha activates chaperones	46	4.32e-01	-0.067000	6.57e-01
Methylation	13	6.78e-01	0.066500	8.31e-01
Regulation of CDH11 mRNA translation by microRNAs	8	7.45e-01	0.066400	8.66e-01
Regulation of NPAS4 mRNA translation	8	7.45e-01	0.066400	8.66e-01
Receptor Mediated Mitophagy	11	7.03e-01	-0.066400	8.43e-01
HS-GAG degradation	19	6.17e-01	-0.066400	7.97e-01
Interleukin-17 signaling	68	3.46e-01	-0.066100	5.95e-01
Nef and signal transduction	8	7.47e-01	0.066000	8.67e-01
Signaling by VEGF	100	2.57e-01	-0.065700	4.99e-01
Beta-oxidation of very long chain fatty acids	11	7.08e-01	-0.065200	8.44e-01
G beta:gamma signalling through PLC beta	17	6.42e-01	-0.065200	8.09e-01
Presynaptic function of Kainate receptors	17	6.42e-01	-0.065200	8.09e-01
Regulation of BACH1 activity	11	7.08e-01	0.065100	8.44e-01
Post-transcriptional silencing by small RNAs	7	7.66e-01	-0.064900	8.78e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	7.11e-01	-0.064600	8.45e-01
PKR-mediated signaling	67	3.61e-01	0.064500	6.01e-01
Regulation of RUNX1 Expression and Activity	18	6.36e-01	-0.064400	8.08e-01
CaM pathway	28	5.57e-01	-0.064100	7.57e-01
Calmodulin induced events	28	5.57e-01	-0.064100	7.57e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	5.65e-01	0.064000	7.63e-01
Synaptic adhesion-like molecules	17	6.48e-01	0.064000	8.11e-01
Neddylation	215	1.08e-01	0.063700	3.04e-01
Signaling by EGFR in Cancer	23	5.99e-01	-0.063400	7.86e-01
ER to Golgi Anterograde Transport	145	1.88e-01	-0.063300	4.12e-01
Beta-catenin independent WNT signaling	126	2.22e-01	0.063000	4.55e-01
FLT3 signaling in disease	27	5.71e-01	0.062900	7.69e-01
Cyclin D associated events in G1	47	4.56e-01	0.062900	6.78e-01
G1 Phase	47	4.56e-01	0.062900	6.78e-01
Signaling by MST1	5	8.08e-01	0.062800	9.08e-01
Protein-protein interactions at synapses	61	3.96e-01	0.062800	6.26e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	7.74e-01	0.062700	8.84e-01
Post NMDA receptor activation events	64	3.85e-01	-0.062700	6.20e-01
Ca-dependent events	30	5.57e-01	-0.061900	7.57e-01
Infectious disease	959	1.24e-03	0.061600	1.11e-02
Class A/1 (Rhodopsin-like receptors)	175	1.61e-01	-0.061400	3.82e-01
HATs acetylate histones	92	3.10e-01	-0.061300	5.60e-01
GPCR downstream signalling	398	3.70e-02	-0.060900	1.53e-01
Diseases of Mismatch Repair (MMR)	5	8.14e-01	-0.060900	9.13e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	7.66e-01	0.060700	8.78e-01
Signal Transduction	2058	5.90e-06	-0.060500	1.07e-04
Activated NTRK2 signals through RAS	6	7.97e-01	-0.060500	9.01e-01
Death Receptor Signaling	145	2.09e-01	0.060500	4.38e-01
RAS processing	23	6.16e-01	-0.060400	7.97e-01
SHC-mediated cascade:FGFR3	10	7.41e-01	-0.060400	8.65e-01
Thyroxine biosynthesis	5	8.15e-01	0.060300	9.14e-01
Maturation of protein 3a 9683673	9	7.54e-01	0.060200	8.72e-01
Maturation of protein 3a 9694719	9	7.54e-01	0.060200	8.72e-01
Vitamin C (ascorbate) metabolism	8	7.68e-01	-0.060200	8.79e-01
Nicotinamide salvaging	15	6.86e-01	-0.060200	8.33e-01
FLT3 Signaling	38	5.22e-01	-0.060100	7.29e-01
Mitotic Spindle Checkpoint	108	2.82e-01	-0.059900	5.31e-01
Signaling by Erythropoietin	24	6.13e-01	-0.059700	7.96e-01
Glucose metabolism	76	3.70e-01	0.059500	6.07e-01
Autophagy	142	2.23e-01	0.059200	4.56e-01
Wax and plasmalogen biosynthesis	5	8.19e-01	-0.059200	9.15e-01
CD28 co-stimulation	33	5.58e-01	0.059000	7.57e-01
Elevation of cytosolic Ca2+ levels	13	7.14e-01	-0.058700	8.47e-01
Activation of RAC1	11	7.36e-01	-0.058600	8.64e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	5.85e-01	-0.058600	7.77e-01
Transcriptional regulation of testis differentiation	5	8.21e-01	-0.058500	9.16e-01
ERKs are inactivated	13	7.16e-01	0.058200	8.48e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	1.68e-01	-0.057900	3.91e-01
CREB phosphorylation	7	7.92e-01	-0.057400	8.97e-01
Phosphate bond hydrolysis by NTPDase proteins	5	8.24e-01	-0.057300	9.19e-01
Ovarian tumor domain proteases	37	5.47e-01	-0.057200	7.53e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	6.93e-01	0.057000	8.40e-01
Mitotic Prophase	96	3.35e-01	-0.057000	5.83e-01
Metabolism of vitamins and cofactors	166	2.05e-01	0.057000	4.37e-01
Beta-oxidation of pristanoyl-CoA	9	7.67e-01	0.056900	8.79e-01
Defective B3GAT3 causes JDSSDHD	11	7.44e-01	0.056900	8.66e-01
Signaling by NTRKs	117	2.89e-01	-0.056800	5.39e-01
Cellular Senescence	143	2.42e-01	-0.056700	4.83e-01
Negative regulation of FGFR2 signaling	24	6.32e-01	-0.056500	8.06e-01
TGFBR3 expression	20	6.64e-01	0.056200	8.23e-01
Opioid Signalling	75	4.02e-01	-0.055900	6.32e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	5.96e-01	-0.055900	7.84e-01
Downregulation of ERBB2 signaling	24	6.38e-01	0.055500	8.08e-01
Nephron development	5	8.30e-01	0.055400	9.22e-01
Macroautophagy	128	2.83e-01	0.054900	5.31e-01
EPH-ephrin mediated repulsion of cells	43	5.35e-01	0.054700	7.43e-01
Signaling by PDGFR in disease	19	6.80e-01	-0.054600	8.31e-01
Regulation of KIT signaling	15	7.15e-01	-0.054500	8.48e-01
Processing of Intronless Pre-mRNAs	20	6.74e-01	0.054400	8.29e-01
Regulation of pyruvate metabolism	32	5.96e-01	-0.054200	7.84e-01
Cytochrome P450 - arranged by substrate type	38	5.63e-01	0.054200	7.62e-01
Platelet calcium homeostasis	22	6.62e-01	-0.053900	8.21e-01
Sema3A PAK dependent Axon repulsion	15	7.19e-01	0.053700	8.49e-01
SUMOylation of transcription factors	16	7.11e-01	0.053500	8.45e-01
Stimuli-sensing channels	81	4.06e-01	-0.053400	6.36e-01
RHO GTPase cycle	412	6.31e-02	-0.053400	2.11e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	8.37e-01	0.053300	9.23e-01
Cross-presentation of particulate exogenous antigens (phagosomes)	8	7.94e-01	-0.053200	8.99e-01
Voltage gated Potassium channels	26	6.40e-01	-0.053100	8.09e-01
RA biosynthesis pathway	13	7.41e-01	0.053000	8.65e-01
Platelet homeostasis	69	4.49e-01	-0.052700	6.71e-01
Apoptosis	158	2.55e-01	0.052500	4.97e-01
Regulation of TP53 Activity through Association with Co-factors	13	7.44e-01	-0.052300	8.66e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	5.89e-01	0.052000	7.79e-01
MyD88-independent TLR4 cascade	108	3.51e-01	0.052000	5.98e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	3.51e-01	0.052000	5.98e-01
COPI-dependent Golgi-to-ER retrograde traffic	90	3.94e-01	-0.052000	6.26e-01
COPII-mediated vesicle transport	67	4.62e-01	-0.052000	6.83e-01
Diseases associated with the TLR signaling cascade	29	6.28e-01	0.051900	8.04e-01
Diseases of Immune System	29	6.28e-01	0.051900	8.04e-01
Toll-like Receptor Cascades	162	2.54e-01	0.051900	4.97e-01
Phosphate bond hydrolysis by NUDT proteins	7	8.12e-01	0.051900	9.13e-01
Bacterial Infection Pathways	66	4.67e-01	-0.051800	6.86e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	7.56e-01	0.051700	8.73e-01
alpha-linolenic acid (ALA) metabolism	12	7.56e-01	0.051700	8.73e-01
Inflammasomes	21	6.82e-01	0.051700	8.31e-01
Toll Like Receptor 3 (TLR3) Cascade	104	3.64e-01	0.051500	6.04e-01
Activation of SMO	13	7.48e-01	0.051500	8.68e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	6.84e-01	-0.051300	8.32e-01
Neurodegenerative Diseases	21	6.84e-01	-0.051300	8.32e-01
CTLA4 inhibitory signaling	21	6.85e-01	-0.051200	8.32e-01
G-protein beta:gamma signalling	29	6.34e-01	-0.051100	8.08e-01
Formation of the beta-catenin:TCF transactivating complex	44	5.59e-01	-0.050900	7.58e-01
Calnexin/calreticulin cycle	26	6.54e-01	-0.050900	8.15e-01
Regulation of NPAS4 gene expression	11	7.70e-01	0.050800	8.81e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	6.75e-01	0.050400	8.31e-01
RNA Polymerase II Transcription	1206	3.45e-03	0.050000	2.60e-02
GPCR ligand binding	241	1.82e-01	-0.049900	4.07e-01
SUMO is proteolytically processed	6	8.33e-01	0.049800	9.22e-01
Keratan sulfate biosynthesis	20	7.00e-01	-0.049700	8.43e-01
Synthesis of IP3 and IP4 in the cytosol	22	6.88e-01	-0.049400	8.35e-01
Gene expression (Transcription)	1413	1.95e-03	0.049200	1.61e-02
Regulation of MECP2 expression and activity	29	6.47e-01	0.049200	8.10e-01
Phase II - Conjugation of compounds	71	4.74e-01	-0.049100	6.92e-01
Assembly of collagen fibrils and other multimeric structures	44	5.75e-01	-0.048900	7.71e-01
TP53 Regulates Transcription of Cell Death Genes	43	5.79e-01	0.048900	7.75e-01
Listeria monocytogenes entry into host cells	17	7.28e-01	0.048800	8.56e-01
Diseases associated with O-glycosylation of proteins	50	5.52e-01	-0.048600	7.54e-01
Transport of nucleotide sugars	9	8.02e-01	-0.048200	9.04e-01
Signaling by GPCR	442	8.30e-02	-0.048100	2.57e-01
Sensory processing of sound by inner hair cells of the cochlea	54	5.42e-01	0.047900	7.47e-01
Regulation of lipid metabolism by PPARalpha	107	3.93e-01	0.047800	6.26e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	8.05e-01	0.047500	9.07e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	5.21e-01	0.047500	7.29e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	8.28e-01	0.047300	9.22e-01
RND1 GTPase cycle	37	6.19e-01	-0.047300	7.98e-01
Muscle contraction	145	3.28e-01	-0.047100	5.76e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	6.45e-01	0.047000	8.10e-01
Reduction of cytosolic Ca++ levels	9	8.08e-01	-0.046900	9.08e-01
RNA Polymerase I Promoter Clearance	64	5.17e-01	0.046900	7.26e-01
RNA Polymerase I Transcription	64	5.17e-01	0.046900	7.26e-01
Inositol phosphate metabolism	42	6.02e-01	-0.046500	7.89e-01
Sodium/Proton exchangers	7	8.32e-01	0.046200	9.22e-01
HDL remodeling	6	8.46e-01	0.045900	9.27e-01
Ion transport by P-type ATPases	43	6.04e-01	0.045700	7.90e-01
Formation of WDR5-containing histone-modifying complexes	42	6.08e-01	0.045700	7.93e-01
IL-6-type cytokine receptor ligand interactions	13	7.76e-01	0.045600	8.86e-01
Maturation of nucleoprotein 9694631	15	7.61e-01	-0.045400	8.76e-01
Notch-HLH transcription pathway	28	6.78e-01	0.045400	8.31e-01
Downregulation of TGF-beta receptor signaling	26	6.89e-01	-0.045300	8.36e-01
mTORC1-mediated signalling	24	7.01e-01	0.045200	8.43e-01
G alpha (s) signalling events	97	4.42e-01	-0.045200	6.67e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	7.55e-01	-0.045100	8.72e-01
Assembly and cell surface presentation of NMDA receptors	34	6.51e-01	-0.044800	8.13e-01
Molybdenum cofactor biosynthesis	6	8.50e-01	0.044600	9.30e-01
p38MAPK events	13	7.83e-01	-0.044000	8.91e-01
Tight junction interactions	17	7.53e-01	0.044000	8.72e-01
Synthesis of UDP-N-acetyl-glucosamine	8	8.31e-01	-0.043500	9.22e-01
XBP1(S) activates chaperone genes	44	6.18e-01	-0.043500	7.98e-01
TCF dependent signaling in response to WNT	153	3.54e-01	0.043400	5.98e-01
Activation of the pre-replicative complex	32	6.72e-01	-0.043200	8.28e-01
Signaling by NOTCH2	33	6.68e-01	-0.043200	8.25e-01
Regulation of HMOX1 expression and activity	5	8.67e-01	-0.043100	9.40e-01
Interleukin-15 signaling	14	7.82e-01	0.042700	8.90e-01
Metabolism of carbohydrates	241	2.54e-01	-0.042700	4.97e-01
RHOV GTPase cycle	36	6.58e-01	-0.042700	8.19e-01
Receptor-type tyrosine-protein phosphatases	12	7.98e-01	-0.042600	9.02e-01
Lysosome Vesicle Biogenesis	32	6.78e-01	0.042500	8.31e-01
HCMV Early Events	84	5.02e-01	-0.042400	7.13e-01
Regulation of PTEN localization	9	8.26e-01	-0.042400	9.20e-01
MyD88 dependent cascade initiated on endosome	101	4.62e-01	0.042300	6.83e-01
Nucleotide catabolism	28	7.00e-01	0.042100	8.43e-01
CaMK IV-mediated phosphorylation of CREB	9	8.27e-01	0.042000	9.21e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	6.16e-01	-0.041900	7.97e-01
SARS-CoV Infections	433	1.37e-01	0.041700	3.49e-01
Interleukin-1 family signaling	127	4.18e-01	0.041600	6.44e-01
Immune System	1841	3.38e-03	-0.041200	2.57e-02
PKMTs methylate histone lysines	44	6.37e-01	-0.041200	8.08e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	8.51e-01	0.041100	9.30e-01
Collagen formation	66	5.65e-01	-0.040900	7.63e-01
Metabolism of steroids	125	4.33e-01	-0.040600	6.58e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	8.75e-01	-0.040600	9.43e-01
Neurotransmitter release cycle	38	6.66e-01	-0.040400	8.25e-01
Miscellaneous substrates	7	8.53e-01	0.040400	9.32e-01
Phase 2 - plateau phase	11	8.17e-01	0.040300	9.14e-01
Cell-Cell communication	114	4.58e-01	-0.040200	6.80e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	7.62e-01	0.040100	8.76e-01
Telomere Extension By Telomerase	23	7.39e-01	0.040100	8.64e-01
RUNX1 regulates estrogen receptor mediated transcription	6	8.65e-01	-0.040100	9.40e-01
Chromosome Maintenance	103	4.83e-01	0.040000	6.98e-01
DNA Double-Strand Break Repair	137	4.19e-01	0.040000	6.44e-01
PPARA activates gene expression	105	4.79e-01	0.040000	6.95e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	8.36e-01	-0.039900	9.23e-01
TRAF6 mediated NF-kB activation	23	7.42e-01	0.039600	8.66e-01
Metalloprotease DUBs	20	7.60e-01	0.039400	8.76e-01
Lysine catabolism	11	8.23e-01	0.039000	9.18e-01
DAG and IP3 signaling	34	6.97e-01	-0.038600	8.41e-01
Activation of gene expression by SREBF (SREBP)	42	6.65e-01	-0.038600	8.24e-01
NRAGE signals death through JNK	52	6.32e-01	0.038400	8.06e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	8.61e-01	0.038200	9.38e-01
Role of second messengers in netrin-1 signaling	6	8.72e-01	-0.037900	9.41e-01
Toll Like Receptor 9 (TLR9) Cascade	108	4.97e-01	0.037800	7.11e-01
CD28 dependent PI3K/Akt signaling	22	7.60e-01	0.037600	8.76e-01
Transport of vitamins, nucleosides, and related molecules	32	7.14e-01	0.037500	8.47e-01
EPHB-mediated forward signaling	40	6.82e-01	-0.037500	8.31e-01
Adherens junctions interactions	41	6.80e-01	0.037200	8.31e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	8.17e-01	-0.037000	9.14e-01
Surfactant metabolism	21	7.69e-01	-0.037000	8.80e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	7.40e-01	-0.036900	8.64e-01
Signaling by NTRK1 (TRKA)	102	5.22e-01	-0.036700	7.29e-01
Peptide hormone metabolism	54	6.44e-01	0.036400	8.09e-01
Nuclear Envelope (NE) Reassembly	68	6.08e-01	0.036000	7.93e-01
Generic Transcription Pathway	1088	4.49e-02	0.036000	1.73e-01
Signaling by ERBB2 KD Mutants	20	7.80e-01	-0.036000	8.89e-01
Interleukin receptor SHC signaling	23	7.65e-01	-0.036000	8.78e-01
Mitophagy	38	7.02e-01	0.035900	8.43e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	8.79e-01	-0.035800	9.46e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	7.77e-01	0.035700	8.86e-01
Biological oxidations	146	4.57e-01	0.035600	6.79e-01
Cellular response to chemical stress	179	4.12e-01	0.035500	6.40e-01
Formation of apoptosome	11	8.40e-01	0.035100	9.24e-01
Regulation of the apoptosome activity	11	8.40e-01	0.035100	9.24e-01
Mitotic Metaphase and Anaphase	212	3.79e-01	0.035000	6.16e-01
Mitotic Anaphase	211	3.84e-01	0.034800	6.20e-01
Regulation of endogenous retroelements	92	5.65e-01	0.034700	7.63e-01
Regulation of MITF-M-dependent genes involved in pigmentation	37	7.15e-01	-0.034600	8.48e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	5.53e-01	0.034400	7.55e-01
G alpha (12/13) signalling events	68	6.27e-01	-0.034000	8.03e-01
PINK1-PRKN Mediated Mitophagy	31	7.44e-01	0.033900	8.66e-01
Cell Cycle	611	1.53e-01	0.033800	3.74e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	8.15e-01	0.033800	9.14e-01
Asparagine N-linked glycosylation	286	3.25e-01	-0.033800	5.74e-01
DAP12 interactions	39	7.18e-01	-0.033400	8.49e-01
Regulation of signaling by CBL	22	7.87e-01	-0.033300	8.93e-01
SHC-mediated cascade:FGFR2	13	8.35e-01	0.033300	9.23e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	8.36e-01	-0.033100	9.23e-01
Adaptive Immune System	768	1.19e-01	-0.033100	3.23e-01
Metabolism of lipids	642	1.55e-01	-0.032900	3.75e-01
Diseases of programmed cell death	58	6.68e-01	-0.032500	8.25e-01
TYSND1 cleaves peroxisomal proteins	7	8.82e-01	0.032500	9.46e-01
Amino acids regulate mTORC1	48	6.97e-01	-0.032500	8.41e-01
Separation of Sister Chromatids	168	4.71e-01	0.032300	6.89e-01
Defective Intrinsic Pathway for Apoptosis	24	7.86e-01	0.032000	8.92e-01
IkBA variant leads to EDA-ID	7	8.85e-01	0.031600	9.48e-01
Mitotic Prometaphase	193	4.52e-01	-0.031400	6.75e-01
M Phase	346	3.18e-01	0.031200	5.67e-01
G2/M Checkpoints	126	5.48e-01	0.031000	7.54e-01
WNT5A-dependent internalization of FZD4	13	8.47e-01	-0.030900	9.28e-01
RHOU GTPase cycle	40	7.37e-01	-0.030600	8.64e-01
Formation of axial mesoderm	6	8.97e-01	0.030500	9.58e-01
p75NTR recruits signalling complexes	12	8.55e-01	-0.030400	9.33e-01
Signaling by ALK fusions and activated point mutants	89	6.20e-01	0.030400	7.98e-01
Signaling by ALK in cancer	89	6.20e-01	0.030400	7.98e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	8.68e-01	0.030200	9.41e-01
Defective B4GALT7 causes EDS, progeroid type	11	8.63e-01	0.030000	9.39e-01
Adipogenesis	96	6.15e-01	0.029700	7.97e-01
Sensory processing of sound	58	6.96e-01	0.029600	8.41e-01
VEGFR2 mediated cell proliferation	18	8.29e-01	-0.029400	9.22e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	8.60e-01	0.029300	9.38e-01
Translation of Structural Proteins 9683701	29	7.86e-01	0.029200	8.92e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	6.11e-01	0.028700	7.95e-01
Processing of DNA double-strand break ends	69	6.80e-01	-0.028700	8.31e-01
Protein folding	83	6.53e-01	0.028600	8.14e-01
Deadenylation of mRNA	22	8.17e-01	0.028400	9.14e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	7.13e-01	-0.028400	8.47e-01
Deubiquitination	225	4.69e-01	-0.028000	6.89e-01
Interleukin-6 family signaling	20	8.29e-01	0.027900	9.22e-01
Pyruvate metabolism	44	7.49e-01	0.027900	8.68e-01
Positive epigenetic regulation of rRNA expression	60	7.09e-01	0.027900	8.44e-01
Metabolism of steroid hormones	22	8.21e-01	0.027900	9.16e-01
Estrogen-dependent gene expression	97	6.36e-01	-0.027800	8.08e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	8.59e-01	-0.027400	9.36e-01
E3 ubiquitin ligases ubiquitinate target proteins	51	7.38e-01	0.027000	8.64e-01
Transcriptional Regulation by TP53	346	3.99e-01	0.026400	6.29e-01
NOD1/2 Signaling Pathway	36	7.86e-01	0.026200	8.92e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	9.20e-01	-0.026000	9.65e-01
MECP2 regulates transcription factors	5	9.20e-01	-0.025900	9.65e-01
Signal regulatory protein family interactions	13	8.72e-01	-0.025900	9.41e-01
RUNX3 regulates WNT signaling	8	8.99e-01	0.025800	9.59e-01
Signaling by KIT in disease	20	8.44e-01	0.025500	9.26e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	8.44e-01	0.025500	9.26e-01
PIP3 activates AKT signaling	235	5.07e-01	0.025100	7.17e-01
Cardiac conduction	89	6.82e-01	-0.025100	8.31e-01
FLT3 signaling through SRC family kinases	6	9.16e-01	0.025000	9.63e-01
Regulation of TP53 Expression and Degradation	36	7.96e-01	-0.024900	9.00e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	6.70e-01	-0.024200	8.26e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	4.93e-01	0.024000	7.07e-01
Zinc transporters	12	8.86e-01	-0.023900	9.49e-01
Activation of caspases through apoptosome-mediated cleavage	6	9.20e-01	0.023700	9.65e-01
Synthesis of PA	31	8.20e-01	0.023700	9.16e-01
MITF-M-regulated melanocyte development	113	6.67e-01	-0.023400	8.25e-01
DNA Damage Reversal	8	9.09e-01	0.023300	9.61e-01
SHC1 events in ERBB4 signaling	10	8.98e-01	-0.023300	9.59e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	9.00e-01	-0.023100	9.59e-01
Defective EXT2 causes exostoses 2	10	9.00e-01	-0.023100	9.59e-01
Cell Cycle, Mitotic	488	3.83e-01	0.023000	6.20e-01
p75 NTR receptor-mediated signalling	89	7.07e-01	0.023000	8.44e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	9.29e-01	-0.022900	9.69e-01
Maple Syrup Urine Disease	5	9.29e-01	-0.022900	9.69e-01
TRP channels	22	8.53e-01	-0.022900	9.32e-01
Transport of small molecules	558	3.64e-01	-0.022500	6.04e-01
MITF-M-dependent gene expression	83	7.24e-01	-0.022400	8.53e-01
Chaperonin-mediated protein folding	77	7.38e-01	0.022100	8.64e-01
HDR through Homologous Recombination (HRR)	68	7.53e-01	0.022100	8.72e-01
Nef Mediated CD8 Down-regulation	7	9.20e-01	-0.022000	9.65e-01
Signaling by FGFR in disease	52	7.84e-01	0.022000	8.92e-01
WNT mediated activation of DVL	8	9.15e-01	0.021900	9.63e-01
ALK mutants bind TKIs	11	9.00e-01	0.021900	9.59e-01
Disease	1633	1.41e-01	0.021900	3.55e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	8.72e-01	0.021900	9.41e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	8.72e-01	0.021900	9.41e-01
Acyl chain remodelling of PE	20	8.67e-01	0.021600	9.40e-01
HCMV Late Events	67	7.60e-01	-0.021500	8.76e-01
Cytoprotection by HMOX1	53	7.87e-01	-0.021400	8.93e-01
Glucagon-type ligand receptors	20	8.70e-01	-0.021100	9.41e-01
Glycolysis	68	7.65e-01	0.021000	8.78e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	7.08e-01	-0.020800	8.44e-01
Toll Like Receptor TLR6:TLR2 Cascade	108	7.08e-01	-0.020800	8.44e-01
Toll Like Receptor 4 (TLR4) Cascade	138	6.77e-01	0.020500	8.31e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	8.46e-01	-0.020500	9.27e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	8.68e-01	-0.020500	9.40e-01
RHOBTB3 ATPase cycle	10	9.13e-01	0.020000	9.63e-01
Diseases of glycosylation	109	7.23e-01	-0.019600	8.52e-01
Cell death signalling via NRAGE, NRIF and NADE	69	7.78e-01	0.019600	8.87e-01
Retrograde transport at the Trans-Golgi-Network	49	8.13e-01	0.019500	9.13e-01
VLDLR internalisation and degradation	16	8.93e-01	-0.019400	9.54e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	9.07e-01	0.019400	9.61e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	8.05e-01	0.019100	9.07e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	8.68e-01	0.018900	9.40e-01
ERK/MAPK targets	22	8.79e-01	0.018800	9.46e-01
Cell-cell junction organization	60	8.01e-01	0.018800	9.04e-01
Signaling by Nuclear Receptors	214	6.38e-01	-0.018700	8.08e-01
Ubiquinol biosynthesis	13	9.08e-01	0.018600	9.61e-01
Cell Cycle Checkpoints	246	6.21e-01	-0.018300	7.98e-01
SHC-mediated cascade:FGFR4	11	9.17e-01	0.018200	9.64e-01
Acyl chain remodelling of PC	19	8.93e-01	-0.017800	9.54e-01
Phase 0 - rapid depolarisation	24	8.81e-01	0.017700	9.46e-01
Circadian Clock	67	8.02e-01	0.017700	9.04e-01
Uptake and actions of bacterial toxins	28	8.72e-01	-0.017700	9.41e-01
Negative regulation of MAPK pathway	42	8.43e-01	0.017700	9.26e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	9.03e-01	0.017600	9.60e-01
Ub-specific processing proteases	153	7.09e-01	0.017500	8.44e-01
MHC class II antigen presentation	113	7.53e-01	0.017100	8.72e-01
Ketone body metabolism	8	9.34e-01	-0.017000	9.69e-01
Maturation of nucleoprotein 9683610	11	9.23e-01	-0.016900	9.67e-01
Ion channel transport	141	7.31e-01	-0.016800	8.60e-01
TRAF6 mediated IRF7 activation	15	9.12e-01	0.016400	9.63e-01
Intracellular signaling by second messengers	268	6.44e-01	0.016400	8.09e-01
Nuclear Envelope Breakdown	53	8.37e-01	0.016300	9.23e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	8.80e-01	-0.016100	9.46e-01
PECAM1 interactions	12	9.23e-01	0.016100	9.67e-01
Signaling by NOTCH	175	7.16e-01	0.015900	8.48e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	9.09e-01	0.015900	9.61e-01
RAF activation	33	8.74e-01	-0.015900	9.43e-01
HDR through Single Strand Annealing (SSA)	37	8.67e-01	0.015900	9.40e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	55	8.39e-01	0.015800	9.23e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	55	8.39e-01	0.015800	9.23e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	55	8.39e-01	0.015800	9.23e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	55	8.39e-01	0.015800	9.23e-01
Signaling by NOTCH1 in Cancer	55	8.39e-01	0.015800	9.23e-01
Class I MHC mediated antigen processing & presentation	344	6.14e-01	0.015800	7.97e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	11	9.29e-01	0.015500	9.69e-01
Negative epigenetic regulation of rRNA expression	63	8.34e-01	0.015200	9.23e-01
FasL/ CD95L signaling	5	9.53e-01	-0.015200	9.79e-01
Class B/2 (Secretin family receptors)	55	8.46e-01	0.015100	9.27e-01
Transcriptional activation of mitochondrial biogenesis	52	8.55e-01	0.014600	9.33e-01
Impaired BRCA2 binding to RAD51	35	8.81e-01	0.014600	9.46e-01
TNFs bind their physiological receptors	25	9.01e-01	0.014400	9.59e-01
Formation of the nephric duct	8	9.45e-01	0.014100	9.76e-01
Diseases of DNA repair	51	8.62e-01	0.014000	9.39e-01
MAPK family signaling cascades	264	6.97e-01	-0.013900	8.41e-01
NoRC negatively regulates rRNA expression	60	8.54e-01	0.013700	9.33e-01
Transferrin endocytosis and recycling	26	9.08e-01	0.013100	9.61e-01
KEAP1-NFE2L2 pathway	107	8.17e-01	0.012900	9.14e-01
ROS and RNS production in phagocytes	30	9.04e-01	-0.012700	9.61e-01
Biosynthesis of DHA-derived SPMs	15	9.32e-01	-0.012600	9.69e-01
A tetrasaccharide linker sequence is required for GAG synthesis	17	9.28e-01	-0.012600	9.69e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	9.61e-01	0.012500	9.85e-01
eNOS activation	12	9.42e-01	-0.012200	9.74e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	8.84e-01	0.012100	9.48e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	9.10e-01	0.012000	9.61e-01
Chromatin modifying enzymes	215	7.64e-01	0.011900	8.78e-01
Chromatin organization	215	7.64e-01	0.011900	8.78e-01
Nitric oxide stimulates guanylate cyclase	15	9.37e-01	0.011900	9.70e-01
Toll Like Receptor 2 (TLR2) Cascade	109	8.31e-01	-0.011800	9.22e-01
Toll Like Receptor TLR1:TLR2 Cascade	109	8.31e-01	-0.011800	9.22e-01
Metabolism of amine-derived hormones	10	9.50e-01	0.011500	9.78e-01
Sensory perception of taste	22	9.26e-01	0.011400	9.68e-01
Signaling by Interleukins	391	6.99e-01	0.011400	8.42e-01
Activation of ATR in response to replication stress	37	9.08e-01	-0.010900	9.61e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	9.05e-01	0.010900	9.61e-01
Signaling by FGFR	73	8.75e-01	0.010600	9.43e-01
Response of Mtb to phagocytosis	22	9.31e-01	-0.010600	9.69e-01
Cell junction organization	82	8.70e-01	-0.010400	9.41e-01
Nuclear signaling by ERBB4	24	9.31e-01	0.010200	9.69e-01
Acyl chain remodelling of PG	11	9.53e-01	-0.010200	9.79e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	9.26e-01	0.010100	9.68e-01
Diseases associated with surfactant metabolism	6	9.66e-01	0.010100	9.87e-01
FGFR3 ligand binding and activation	5	9.69e-01	-0.009930	9.87e-01
FGFR3c ligand binding and activation	5	9.69e-01	-0.009930	9.87e-01
Signaling by NOTCH1	68	8.87e-01	-0.009920	9.50e-01
Free fatty acids regulate insulin secretion	10	9.57e-01	-0.009850	9.81e-01
Signaling by CSF3 (G-CSF)	29	9.28e-01	0.009750	9.69e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	9.51e-01	0.009460	9.78e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	9.51e-01	0.009460	9.78e-01
CHL1 interactions	8	9.63e-01	-0.009390	9.87e-01
G-protein mediated events	44	9.15e-01	-0.009350	9.63e-01
NCAM signaling for neurite out-growth	48	9.15e-01	0.008910	9.63e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	9.70e-01	-0.008760	9.88e-01
Signalling to RAS	19	9.48e-01	-0.008600	9.78e-01
Acyl chain remodeling of CL	5	9.74e-01	0.008550	9.89e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	9.42e-01	0.008530	9.74e-01
EGFR Transactivation by Gastrin	7	9.69e-01	0.008420	9.87e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	9.54e-01	0.008360	9.79e-01
Modulation by Mtb of host immune system	7	9.70e-01	0.008330	9.87e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	9.33e-01	0.008260	9.69e-01
DNA Double Strand Break Response	47	9.23e-01	0.008100	9.67e-01
Signaling by FGFR2	61	9.13e-01	-0.008070	9.63e-01
Protein ubiquitination	71	9.07e-01	-0.008000	9.61e-01
Selective autophagy	77	9.04e-01	0.007970	9.61e-01
HCMV Infection	106	8.92e-01	-0.007660	9.54e-01
Relaxin receptors	5	9.76e-01	0.007640	9.91e-01
FGFRL1 modulation of FGFR1 signaling	7	9.72e-01	0.007630	9.89e-01
FGFR2 ligand binding and activation	9	9.69e-01	-0.007380	9.87e-01
MTOR signalling	39	9.37e-01	0.007360	9.70e-01
Interaction between L1 and Ankyrins	26	9.50e-01	0.007140	9.78e-01
SUMOylation of transcription cofactors	44	9.35e-01	-0.007060	9.70e-01
Regulation of TP53 Activity	153	8.81e-01	0.007000	9.46e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	9.47e-01	-0.006950	9.77e-01
The canonical retinoid cycle in rods (twilight vision)	9	9.72e-01	0.006770	9.89e-01
Regulation of TP53 Activity through Phosphorylation	88	9.14e-01	-0.006660	9.63e-01
TP53 Regulates Metabolic Genes	78	9.20e-01	-0.006560	9.65e-01
Glycogen storage diseases	13	9.68e-01	0.006410	9.87e-01
Epigenetic regulation of gene expression	263	8.64e-01	0.006130	9.40e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	38	9.53e-01	0.005500	9.79e-01
Aggrephagy	34	9.56e-01	0.005440	9.81e-01
Developmental Biology	929	7.89e-01	0.005190	8.94e-01
MyD88 cascade initiated on plasma membrane	95	9.34e-01	-0.004890	9.69e-01
Toll Like Receptor 10 (TLR10) Cascade	95	9.34e-01	-0.004890	9.69e-01
Toll Like Receptor 5 (TLR5) Cascade	95	9.34e-01	-0.004890	9.69e-01
Transcriptional regulation of white adipocyte differentiation	77	9.43e-01	-0.004740	9.74e-01
Zinc influx into cells by the SLC39 gene family	9	9.81e-01	0.004630	9.94e-01
Unfolded Protein Response (UPR)	84	9.43e-01	-0.004480	9.75e-01
TRAIL signaling	8	9.83e-01	-0.004460	9.94e-01
Post-translational protein modification	1243	7.92e-01	-0.004440	8.97e-01
MAPK1/MAPK3 signaling	232	9.07e-01	-0.004430	9.61e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	9.65e-01	0.003940	9.87e-01
Diseases of DNA Double-Strand Break Repair	41	9.65e-01	0.003940	9.87e-01
Glycogen synthesis	11	9.83e-01	-0.003680	9.94e-01
RAF/MAP kinase cascade	226	9.26e-01	0.003600	9.68e-01
STAT5 Activation	7	9.87e-01	-0.003480	9.94e-01
Signaling by WNT	241	9.27e-01	-0.003440	9.68e-01
Heme degradation	11	9.84e-01	-0.003400	9.94e-01
SUMOylation of intracellular receptors	26	9.77e-01	-0.003280	9.91e-01
Transcriptional regulation by small RNAs	61	9.65e-01	-0.003270	9.87e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	9.86e-01	-0.003070	9.94e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	9.84e-01	-0.003060	9.94e-01
Diseases of metabolism	208	9.40e-01	0.003050	9.73e-01
ATF6 (ATF6-alpha) activates chaperones	12	9.86e-01	0.002870	9.94e-01
Gene Silencing by RNA	87	9.64e-01	0.002800	9.87e-01
p75NTR signals via NF-kB	15	9.85e-01	-0.002750	9.94e-01
Regulation of TP53 Degradation	35	9.79e-01	0.002610	9.92e-01
Striated Muscle Contraction	27	9.82e-01	0.002530	9.94e-01
HDACs deacetylate histones	45	9.77e-01	0.002460	9.91e-01
DAP12 signaling	28	9.84e-01	0.002200	9.94e-01
Diseases of signal transduction by growth factor receptors and second messengers	404	9.46e-01	0.001970	9.76e-01
SLC transporter disorders	77	9.77e-01	-0.001930	9.91e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	9.90e-01	-0.001790	9.96e-01
Sensory processing of sound by outer hair cells of the cochlea	41	9.85e-01	-0.001720	9.94e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	9.90e-01	-0.001660	9.96e-01
NF-kB is activated and signals survival	12	9.94e-01	0.001310	9.97e-01
Nucleotide-like (purinergic) receptors	13	9.94e-01	-0.001200	9.97e-01
Interleukin-2 family signaling	38	9.91e-01	0.001080	9.96e-01
Nicotinate metabolism	26	9.93e-01	0.000956	9.97e-01
Respiratory syncytial virus (RSV) attachment and entry	18	9.95e-01	0.000819	9.97e-01
Ion homeostasis	42	9.94e-01	-0.000720	9.97e-01
Homologous DNA Pairing and Strand Exchange	43	9.94e-01	0.000680	9.97e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	9.95e-01	-0.000487	9.97e-01
Homology Directed Repair	110	9.93e-01	-0.000476	9.97e-01
Cytochrome c-mediated apoptotic response	13	9.99e-01	-0.000301	9.99e-01
Signaling by ERBB4	45	9.98e-01	0.000204	9.99e-01
PLC beta mediated events	40	9.99e-01	-0.000118	9.99e-01

---

Detailed Gene set reports

RUNX1 regulates expression of components of tight junctions

set	RUNX1 regulates expression of components of tight junctions
setSize	5
pANOVA	0.00123
s.dist	-0.834
p.adjustANOVA	0.0111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLDN5	-10229
OCLN	-8946
TJP1	-8926
RUNX1	-8625
CBFB	-7090

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLDN5	-10229
OCLN	-8946
TJP1	-8926
RUNX1	-8625
CBFB	-7090

---

APOBEC3G mediated resistance to HIV-1 infection

set	APOBEC3G mediated resistance to HIV-1 infection
setSize	5
pANOVA	0.00284
s.dist	0.771
p.adjustANOVA	0.0224

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOBEC3G	10205
HMGA1	9656
PSIP1	9561
BANF1	8462
PPIA	6553

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOBEC3G	10205
HMGA1	9656
PSIP1	9561
BANF1	8462
PPIA	6553

---

CD163 mediating an anti-inflammatory response

set	CD163 mediating an anti-inflammatory response
setSize	9
pANOVA	7.62e-05
s.dist	-0.761
p.adjustANOVA	0.00103

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD163	-10585
ADAM17	-10003
FURIN	-9798
RHBDF2	-9689
IL10	-9021
MYH9	-8773
MAPK14	-7787
IL6	-3953
PLK2	-2034

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD163	-10585
ADAM17	-10003
FURIN	-9798
RHBDF2	-9689
IL10	-9021
MYH9	-8773
MAPK14	-7787
IL6	-3953
PLK2	-2034

---

Formation of the ureteric bud

set	Formation of the ureteric bud
setSize	5
pANOVA	0.0033
s.dist	-0.759
p.adjustANOVA	0.0253

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FOXC1	-10554
GREM1	-8830
WNT11	-7474
ITGB1	-7170
RET	-5639

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FOXC1	-10554
GREM1	-8830
WNT11	-7474
ITGB1	-7170
RET	-5639

---

RUNX1 regulates transcription of genes involved in BCR signaling

set	RUNX1 regulates transcription of genes involved in BCR signaling
setSize	6
pANOVA	0.00146
s.dist	-0.75
p.adjustANOVA	0.0128

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ELF1	-9059
RUNX1	-8625
BLK	-8248
ELF2	-7562
CBFB	-7090
PAX5	-6435

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ELF1	-9059
RUNX1	-8625
BLK	-8248
ELF2	-7562
CBFB	-7090
PAX5	-6435

---

Phenylalanine metabolism

set	Phenylalanine metabolism
setSize	5
pANOVA	0.00432
s.dist	0.737
p.adjustANOVA	0.0301

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ASRGL1	11391
IL4I1	11324
KYAT1	10197
QDPR	7667
PCBD1	1995

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ASRGL1	11391
IL4I1	11324
KYAT1	10197
QDPR	7667
PCBD1	1995

---

Biosynthesis of Lipoxins (LX)

set	Biosynthesis of Lipoxins (LX)
setSize	6
pANOVA	0.00253
s.dist	-0.712
p.adjustANOVA	0.0202

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HPGD	-10279
ALOX5AP	-9683
ALOX5	-9223
ALOX12	-6559
PTGR1	-6324
LTC4S	-2428

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HPGD	-10279
ALOX5AP	-9683
ALOX5	-9223
ALOX12	-6559
PTGR1	-6324
LTC4S	-2428

---

RUNX3 regulates BCL2L11 (BIM) transcription

set	RUNX3 regulates BCL2L11 (BIM) transcription
setSize	5
pANOVA	0.00796
s.dist	-0.685
p.adjustANOVA	0.0485

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FOXO3	-10553
BCL2L11	-10262
RUNX3	-8772
SMAD4	-6353
SMAD3	316

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FOXO3	-10553
BCL2L11	-10262
RUNX3	-8772
SMAD4	-6353
SMAD3	316

---

POLB-Dependent Long Patch Base Excision Repair

set	POLB-Dependent Long Patch Base Excision Repair
setSize	8
pANOVA	0.000926
s.dist	0.676
p.adjustANOVA	0.0086

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLB	11255
LIG1	11202
PARP2	11129
APEX1	10852
PARG	6055
PARP1	4576
FEN1	4247
ADPRS	3449

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLB	11255
LIG1	11202
PARP2	11129
APEX1	10852
PARG	6055
PARP1	4576
FEN1	4247
ADPRS	3449

---

Peptide chain elongation

set	Peptide chain elongation
setSize	88
pANOVA	8.08e-27
s.dist	0.66
p.adjustANOVA	2.23e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
RPS15	6970
RPS3	6946
EEF1A1	6919
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
RPL28	4613
RPS4X	4506
UBA52	3287
RPL22L1	2000
EEF2	1954
RPS4Y1	1386
RPS27L	783
RPL36AL	-1886

---

Eukaryotic Translation Elongation

set	Eukaryotic Translation Elongation
setSize	93
pANOVA	1.16e-27
s.dist	0.653
p.adjustANOVA	3.75e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
EEF1B2	10116
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
EEF1B2	10116
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
EEF1G	7574
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
EEF1D	7036
RPS15	6970
RPS3	6946
EEF1A1	6919
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
EEF1A2	5613
RPL8	5366
RPL15	5305
RPS28	5156
RPL28	4613
RPS4X	4506
UBA52	3287
RPL22L1	2000
EEF2	1954
RPS4Y1	1386
RPS27L	783
EEF1A1P5	295
RPL36AL	-1886

---

Formation of a pool of free 40S subunits

set	Formation of a pool of free 40S subunits
setSize	100
pANOVA	7.33e-29
s.dist	0.644
p.adjustANOVA	4.72e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	10848
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	10848
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
EIF3K	7978
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
EIF3G	7719
EIF3F	7666
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
RPS15	6970
RPS3	6946
RPL32	6857
RPS23	6844
RPLP0	6805
EIF3D	6803
RPS29	6557
RPL41	6420
RPL3L	6204
EIF3I	6063
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
EIF3A	5508
EIF3H	5415
RPL8	5366
RPL15	5305
RPS28	5156
EIF3L	5141
EIF3M	5073
EIF3J	4658
RPL28	4613
EIF3E	4549
RPS4X	4506
EIF3B	3601
UBA52	3287
RPL22L1	2000
EIF1AX	1536
RPS4Y1	1386
RPS27L	783
RPL36AL	-1886

---

SARS-CoV-1 modulates host translation machinery

set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	2.63e-11
s.dist	0.642
p.adjustANOVA	9.06e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	10230
RPS18	9933
RPS17	9887
RPS27A	9825
RPS3A	9711
RPS8	9139
RPS24	9103
RPS15A	9099
RPS20	9095
RPS10	8891
RPS25	8697
RPS6	8554
RPS21	8505
RPS13	8223
RPS2	8087
RPS9	7840
RPSA	7817
RPS5	7781
RPS19	7746
RPS26	7632

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	10230
RPS18	9933
RPS17	9887
RPS27A	9825
RPS3A	9711
RPS8	9139
RPS24	9103
RPS15A	9099
RPS20	9095
RPS10	8891
RPS25	8697
RPS6	8554
RPS21	8505
RPS13	8223
RPS2	8087
RPS9	7840
RPSA	7817
RPS5	7781
RPS19	7746
RPS26	7632
RPS27	7601
RPS7	7537
FAU	7371
RPS15	6970
RPS3	6946
EEF1A1	6919
RPS23	6844
RPS29	6557
HNRNPA1	6352
RPS16	6014
RPS11	5918
RPS14	5824
RPS28	5156
RPS4X	4506
RPS4Y1	1386
RPS27L	783

---

Eukaryotic Translation Termination

set	Eukaryotic Translation Termination
setSize	92
pANOVA	1.93e-26
s.dist	0.641
p.adjustANOVA	4.13e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
TRMT112	9255
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
TRMT112	9255
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
N6AMT1	8992
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
GSPT2	7294
RPS15	6970
RPS3	6946
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
APEH	6258
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
RPL28	4613
RPS4X	4506
UBA52	3287
RPL22L1	2000
RPS4Y1	1386
RPS27L	783
RPL36AL	-1886
ETF1	-3468
GSPT1	-8447

---

Viral mRNA Translation

set	Viral mRNA Translation
setSize	88
pANOVA	2.34e-25
s.dist	0.641
p.adjustANOVA	3.48e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
RPS15	6970
RPS3	6946
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
RPL28	4613
RPS4X	4506
UBA52	3287
RPL22L1	2000
RPS4Y1	1386
RPS27L	783
GRSF1	-1505
RPL36AL	-1886
DNAJC3	-8338

---

Selenocysteine synthesis

set	Selenocysteine synthesis
setSize	92
pANOVA	6.81e-26
s.dist	0.634
p.adjustANOVA	1.1e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
SARS1	9892
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
SARS1	9892
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
RPS15	6970
RPS3	6946
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
EEFSEC	6550
RPL41	6420
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
RPL28	4613
RPS4X	4506
UBA52	3287
SEPHS2	2776
RPL22L1	2000
SECISBP2	1493
RPS4Y1	1386
RPS27L	783
RPL36AL	-1886
PSTK	-3869
SEPSECS	-4128

---

RHOT1 GTPase cycle

set	RHOT1 GTPase cycle
setSize	5
pANOVA	0.0147
s.dist	-0.63
p.adjustANOVA	0.0814

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAP1GDS1	-9551
TRAK2	-9498
RHOT1	-9486
TRAK1	-3092
MYO19	-945

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAP1GDS1	-9551
TRAK2	-9498
RHOT1	-9486
TRAK1	-3092
MYO19	-945

---

TNFR1-mediated ceramide production

set	TNFR1-mediated ceramide production
setSize	6
pANOVA	0.00911
s.dist	0.615
p.adjustANOVA	0.0547

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNF	10881
SMPD2	9888
NSMAF	8254
SMPD3	6687
RACK1	4853
TNFRSF1A	2464

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNF	10881
SMPD2	9888
NSMAF	8254
SMPD3	6687
RACK1	4853
TNFRSF1A	2464

---

G2 Phase

set	G2 Phase
setSize	5
pANOVA	0.0205
s.dist	-0.598
p.adjustANOVA	0.1

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCNA1	-10334
E2F3	-10275
E2F1	-7898
CCNA2	-6919
CDK2	4580

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCNA1	-10334
E2F3	-10275
E2F1	-7898
CCNA2	-6919
CDK2	4580

---

Propionyl-CoA catabolism

set	Propionyl-CoA catabolism
setSize	5
pANOVA	0.0215
s.dist	0.594
p.adjustANOVA	0.104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCEE	10674
MMAA	9873
PCCA	7357
PCCB	6914
MMUT	-107

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCEE	10674
MMAA	9873
PCCA	7357
PCCB	6914
MMUT	-107

---

Formation of xylulose-5-phosphate

set	Formation of xylulose-5-phosphate
setSize	5
pANOVA	0.0215
s.dist	0.594
p.adjustANOVA	0.104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1A1	9625
DCXR	9399
SORD	8826
CRYL1	5862
XYLB	996

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1A1	9625
DCXR	9399
SORD	8826
CRYL1	5862
XYLB	996

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	94
pANOVA	4.43e-23
s.dist	0.59
p.adjustANOVA	5.03e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
GSPT2	7294
RPS15	6970
RPS3	6946
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
RPL28	4613
RPS4X	4506
UBA52	3287
NCBP2	2616
RPL22L1	2000
RPS4Y1	1386
RPS27L	783
PABPC1	326
NCBP1	-1241
RPL36AL	-1886
ETF1	-3468
UPF1	-6769
EIF4G1	-8378
GSPT1	-8447

---

NFE2L2 regulates pentose phosphate pathway genes

set	NFE2L2 regulates pentose phosphate pathway genes
setSize	8
pANOVA	0.00406
s.dist	-0.587
p.adjustANOVA	0.0288

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PGD	-9772
G6PD	-9094
CREBBP	-7703
MAFG	-6832
TKT	-6169
NFE2L2	-3240
TALDO1	-3219
EP300	-2292

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PGD	-9772
G6PD	-9094
CREBBP	-7703
MAFG	-6832
TKT	-6169
NFE2L2	-3240
TALDO1	-3219
EP300	-2292

---

GTP hydrolysis and joining of the 60S ribosomal subunit

set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	111
pANOVA	1.35e-26
s.dist	0.586
p.adjustANOVA	3.25e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	10848
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	10848
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
EIF5B	8543
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
EIF3K	7978
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
EIF3G	7719
EIF3F	7666
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
EIF4A1	7220
RPS15	6970
RPS3	6946
RPL32	6857
EIF2S2	6847
RPS23	6844
RPLP0	6805
EIF3D	6803
RPS29	6557
RPL41	6420
RPL3L	6204
EIF3I	6063
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
EIF3A	5508
EIF3H	5415
RPL8	5366
RPL15	5305
RPS28	5156
EIF3L	5141
EIF3M	5073
EIF4A2	4808
EIF3J	4658
RPL28	4613
EIF3E	4549
RPS4X	4506
EIF3B	3601
UBA52	3287
RPL22L1	2000
EIF2S1	1571
EIF1AX	1536
RPS4Y1	1386
RPS27L	783
EIF4H	98
EIF5	42
RPL36AL	-1886
EIF4E	-2373
EIF4B	-3071
EIF2S3	-4692
EIF4G1	-8378

---

Translocation of ZAP-70 to Immunological synapse

set	Translocation of ZAP-70 to Immunological synapse
setSize	24
pANOVA	6.89e-07
s.dist	0.585
p.adjustANOVA	1.62e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	11350
TRAC	11349
TRBC1	11121
TRAV8-4	10990
CD4	10688
HLA-DPA1	10635
HLA-DQA1	10581
HLA-DRA	10568
ZAP70	10120
TRBV12-3	9909
CD3E	9126
HLA-DRB1	8700
HLA-DPB1	8585
CD247	8105
HLA-DQB2	7184
TRAV19	7096
CD3D	5158
HLA-DQB1	4582
HLA-DRB5	4157
TRBV7-9	2287

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	11350
TRAC	11349
TRBC1	11121
TRAV8-4	10990
CD4	10688
HLA-DPA1	10635
HLA-DQA1	10581
HLA-DRA	10568
ZAP70	10120
TRBV12-3	9909
CD3E	9126
HLA-DRB1	8700
HLA-DPB1	8585
CD247	8105
HLA-DQB2	7184
TRAV19	7096
CD3D	5158
HLA-DQB1	4582
HLA-DRB5	4157
TRBV7-9	2287
PTPN22	1058
HLA-DQA2	179
TRAV29DV5	-2906
CD3G	-6430

---

G2/M DNA replication checkpoint

set	G2/M DNA replication checkpoint
setSize	5
pANOVA	0.0234
s.dist	-0.585
p.adjustANOVA	0.11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WEE1	-10349
PKMYT1	-8158
CDK1	-7313
CCNB2	-6113
CCNB1	1812

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WEE1	-10349
PKMYT1	-8158
CDK1	-7313
CCNB2	-6113
CCNB1	1812

---

L13a-mediated translational silencing of Ceruloplasmin expression

set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	110
pANOVA	2.86e-26
s.dist	0.584
p.adjustANOVA	5.53e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	10848
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	10848
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
EIF3K	7978
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
EIF3G	7719
EIF3F	7666
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
EIF4A1	7220
RPS15	6970
RPS3	6946
RPL32	6857
EIF2S2	6847
RPS23	6844
RPLP0	6805
EIF3D	6803
RPS29	6557
RPL41	6420
RPL3L	6204
EIF3I	6063
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
EIF3A	5508
EIF3H	5415
RPL8	5366
RPL15	5305
RPS28	5156
EIF3L	5141
EIF3M	5073
EIF4A2	4808
EIF3J	4658
RPL28	4613
EIF3E	4549
RPS4X	4506
EIF3B	3601
UBA52	3287
RPL22L1	2000
EIF2S1	1571
EIF1AX	1536
RPS4Y1	1386
RPS27L	783
PABPC1	326
EIF4H	98
RPL36AL	-1886
EIF4E	-2373
EIF4B	-3071
EIF2S3	-4692
EIF4G1	-8378

---

Cap-dependent Translation Initiation

set	Cap-dependent Translation Initiation
setSize	118
pANOVA	5.65e-28
s.dist	0.584
p.adjustANOVA	2.18e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	10848
EIF2B1	10835
EIF2B3	10721
RPL27A	10613
RPL13	10383
EIF2B5	10234
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	10848
EIF2B1	10835
EIF2B3	10721
RPL27A	10613
RPL13	10383
EIF2B5	10234
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
EIF5B	8543
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
EIF3K	7978
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
EIF3G	7719
EIF3F	7666
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
EIF4A1	7220
RPS15	6970
RPS3	6946
RPL32	6857
EIF2S2	6847
RPS23	6844
RPLP0	6805
EIF3D	6803
RPS29	6557
RPL41	6420
RPL3L	6204
EIF3I	6063
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
EIF3A	5508
EIF3H	5415
RPL8	5366
RPL15	5305
RPS28	5156
EIF3L	5141
EIF3M	5073
EIF4A2	4808
EIF4EBP1	4799
EIF3J	4658
RPL28	4613
EIF2B2	4591
EIF3E	4549
RPS4X	4506
EIF3B	3601
UBA52	3287
EIF2B4	3265
RPL22L1	2000
EIF2S1	1571
EIF1AX	1536
RPS4Y1	1386
RPS27L	783
PABPC1	326
EIF4H	98
EIF5	42
RPL36AL	-1886
EIF4E	-2373
EIF4B	-3071
EIF2S3	-4692
EIF4G1	-8378

---

Eukaryotic Translation Initiation

set	Eukaryotic Translation Initiation
setSize	118
pANOVA	5.65e-28
s.dist	0.584
p.adjustANOVA	2.18e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	10848
EIF2B1	10835
EIF2B3	10721
RPL27A	10613
RPL13	10383
EIF2B5	10234
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	10848
EIF2B1	10835
EIF2B3	10721
RPL27A	10613
RPL13	10383
EIF2B5	10234
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
EIF5B	8543
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
EIF3K	7978
RPL13A	7954
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
EIF3G	7719
EIF3F	7666
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
EIF4A1	7220
RPS15	6970
RPS3	6946
RPL32	6857
EIF2S2	6847
RPS23	6844
RPLP0	6805
EIF3D	6803
RPS29	6557
RPL41	6420
RPL3L	6204
EIF3I	6063
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
EIF3A	5508
EIF3H	5415
RPL8	5366
RPL15	5305
RPS28	5156
EIF3L	5141
EIF3M	5073
EIF4A2	4808
EIF4EBP1	4799
EIF3J	4658
RPL28	4613
EIF2B2	4591
EIF3E	4549
RPS4X	4506
EIF3B	3601
UBA52	3287
EIF2B4	3265
RPL22L1	2000
EIF2S1	1571
EIF1AX	1536
RPS4Y1	1386
RPS27L	783
PABPC1	326
EIF4H	98
EIF5	42
RPL36AL	-1886
EIF4E	-2373
EIF4B	-3071
EIF2S3	-4692
EIF4G1	-8378

---

CD22 mediated BCR regulation

set	CD22 mediated BCR regulation
setSize	58
pANOVA	2.31e-14
s.dist	-0.579
p.adjustANOVA	1.14e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV2-29	-10267
IGLV1-44	-10148
IGHV4-34	-9842
IGKV2-30	-9449
IGHV3-13	-9447
IGLC3	-9397
IGHV2-5	-9376
IGLV1-51	-9135
IGHV2-70	-8943
IGHV3-33	-8905
IGLC7	-8897
IGHV3-23	-8863
IGLV7-43	-8854
IGLV2-23	-8808
IGKV3-15	-8768
IGLC1	-8742
IGKV1-33	-8710
IGHV3-7	-8648
IGKC	-8511
IGLC2	-8389

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV2-29	-10267
IGLV1-44	-10148
IGHV4-34	-9842
IGKV2-30	-9449
IGHV3-13	-9447
IGLC3	-9397
IGHV2-5	-9376
IGLV1-51	-9135
IGHV2-70	-8943
IGHV3-33	-8905
IGLC7	-8897
IGHV3-23	-8863
IGLV7-43	-8854
IGLV2-23	-8808
IGKV3-15	-8768
IGLC1	-8742
IGKV1-33	-8710
IGHV3-7	-8648
IGKC	-8511
IGLC2	-8389
IGHM	-8320
IGHV4-59	-8270
IGHV1-2	-7935
IGLV2-8	-7928
IGHV1-69	-7877
IGKV2-28	-7694
IGKV1D-39	-7513
IGLV3-19	-7506
IGHV1-46	-7443
CD79A	-7372
IGKV1-5	-7302
IGLV1-40	-6608
IGLV1-47	-6100
IGKV2D-28	-5947
IGHV3-30	-5936
IGKV1-16	-5500
IGKV4-1	-5327
IGKV3-11	-5171
IGLV2-11	-5095
IGHV3-11	-5045
IGLV6-57	-4869
IGKV3-20	-4791
IGLV3-25	-4770
IGKV1-17	-4621
IGHV3-53	-4521
IGLV3-27	-3958
IGLV3-1	-3878
IGHV4-39	-3479
IGHD	-2851
CD22	-2623
IGLV3-21	-2421
IGLV2-14	-1743
IGKV3D-20	-150
IGKV1-12	-95
IGHV3-48	720
LYN	5502
CD79B	5602
PTPN6	6354

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	100
pANOVA	3.67e-23
s.dist	0.573
p.adjustANOVA	4.43e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATF3	10792
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATF3	10792
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
ASNS	7949
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
RPS15	6970
RPS3	6946
RPL32	6857
EIF2S2	6847
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
RPL3L	6204
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
CEBPG	4787
RPL28	4613
RPS4X	4506
DDIT3	4472
UBA52	3287
RPL22L1	2000
ATF4	1634
EIF2S1	1571
RPS4Y1	1386
RPS27L	783
RPL36AL	-1886
TRIB3	-3289
EIF2AK4	-4296
ATF2	-4481
EIF2S3	-4692
IMPACT	-5242
GCN1	-5501
CEBPB	-5975

---

Formation of the ternary complex, and subsequently, the 43S complex

set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	1.45e-12
s.dist	0.573
p.adjustANOVA	6.08e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	10848
RPS12	10230
RPS18	9933
RPS17	9887
RPS27A	9825
RPS3A	9711
RPS8	9139
RPS24	9103
RPS15A	9099
RPS20	9095
RPS10	8891
RPS25	8697
RPS6	8554
RPS21	8505
RPS13	8223
RPS2	8087
EIF3K	7978
RPS9	7840
RPSA	7817
RPS5	7781

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	10848
RPS12	10230
RPS18	9933
RPS17	9887
RPS27A	9825
RPS3A	9711
RPS8	9139
RPS24	9103
RPS15A	9099
RPS20	9095
RPS10	8891
RPS25	8697
RPS6	8554
RPS21	8505
RPS13	8223
RPS2	8087
EIF3K	7978
RPS9	7840
RPSA	7817
RPS5	7781
RPS19	7746
EIF3G	7719
EIF3F	7666
RPS26	7632
RPS27	7601
RPS7	7537
FAU	7371
RPS15	6970
RPS3	6946
EIF2S2	6847
RPS23	6844
EIF3D	6803
RPS29	6557
EIF3I	6063
RPS16	6014
RPS11	5918
RPS14	5824
EIF3A	5508
EIF3H	5415
RPS28	5156
EIF3L	5141
EIF3M	5073
EIF3J	4658
EIF3E	4549
RPS4X	4506
EIF3B	3601
EIF2S1	1571
EIF1AX	1536
RPS4Y1	1386
RPS27L	783
EIF2S3	-4692

---

Scavenging of heme from plasma

set	Scavenging of heme from plasma
setSize	70
pANOVA	1.37e-16
s.dist	-0.571
p.adjustANOVA	9.44e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD163	-10585
IGKV2-29	-10267
IGLV1-44	-10148
IGHV4-34	-9842
IGHA1	-9565
IGKV2-30	-9449
IGHV3-13	-9447
IGLC3	-9397
IGHV2-5	-9376
IGLV7-46	-9362
JCHAIN	-9191
IGLV1-51	-9135
IGLV4-69	-8985
IGHV2-70	-8943
IGHV3-33	-8905
IGLC7	-8897
IGHV3-23	-8863
IGLV7-43	-8854
IGLV2-23	-8808
IGKV3-15	-8768

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD163	-10585
IGKV2-29	-10267
IGLV1-44	-10148
IGHV4-34	-9842
IGHA1	-9565
IGKV2-30	-9449
IGHV3-13	-9447
IGLC3	-9397
IGHV2-5	-9376
IGLV7-46	-9362
JCHAIN	-9191
IGLV1-51	-9135
IGLV4-69	-8985
IGHV2-70	-8943
IGHV3-33	-8905
IGLC7	-8897
IGHV3-23	-8863
IGLV7-43	-8854
IGLV2-23	-8808
IGKV3-15	-8768
IGLC1	-8742
IGKV1-33	-8710
IGHV3-7	-8648
IGKC	-8511
IGLC2	-8389
IGHV4-59	-8270
HP	-8168
IGHA2	-7967
IGHV1-2	-7935
IGLV2-8	-7928
IGHV1-69	-7877
IGLV10-54	-7749
IGKV2-28	-7694
IGKV1D-39	-7513
IGLV3-19	-7506
IGHV1-46	-7443
IGKV1-5	-7302
IGLV8-61	-6696
IGLV1-40	-6608
IGLV1-47	-6100
IGKV2D-28	-5947
IGHV3-30	-5936
IGLV2-18	-5566
IGKV1-16	-5500
IGKV4-1	-5327
IGKV3-11	-5171
IGLV2-11	-5095
IGHV3-11	-5045
IGLV6-57	-4869
IGKV3-20	-4791
IGLV3-25	-4770
IGKV1-17	-4621
IGHV3-53	-4521
LRP1	-4228
IGLV3-27	-3958
IGLV3-1	-3878
IGHV4-39	-3479
HBA1	-3462
HBB	-2942
IGLV5-45	-2748
IGLV3-21	-2421
IGLV2-14	-1743
IGLV4-60	-590
IGKV3D-20	-150
IGKV1-12	-95
IGLV1-36	556
IGHV3-48	720
HPX	6854
IGLV3-12	10526
APOL1	11252

---

Mitochondrial Uncoupling

set	Mitochondrial Uncoupling
setSize	6
pANOVA	0.0162
s.dist	0.567
p.adjustANOVA	0.0854

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC25A14	10980
UCP3	9563
PM20D1	9278
SLC25A27	6057
UCP2	2836
SLC25A4	1164

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC25A14	10980
UCP3	9563
PM20D1	9278
SLC25A27	6057
UCP2	2836
SLC25A4	1164

---

MET activates PI3K/AKT signaling

set	MET activates PI3K/AKT signaling
setSize	5
pANOVA	0.0282
s.dist	-0.567
p.adjustANOVA	0.126

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HGF	-10293
GAB1	-10019
PIK3R1	-8395
PIK3CA	-793
GRB2	392

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HGF	-10293
GAB1	-10019
PIK3R1	-8395
PIK3CA	-793
GRB2	392

---

SARS-CoV-2 modulates host translation machinery

set	SARS-CoV-2 modulates host translation machinery
setSize	49
pANOVA	7.22e-12
s.dist	0.566
p.adjustANOVA	2.68e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS12	10230
RPS18	9933
RPS17	9887
RPS27A	9825
RPS3A	9711
GEMIN6	9260
SNRPD1	9167
RPS8	9139
RPS24	9103
RPS15A	9099
RPS20	9095
GEMIN8	9012
RPS10	8891
RPS25	8697
SNRPE	8634
RPS6	8554
RPS21	8505
RPS13	8223
RPS2	8087
GEMIN7	7918

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS12	10230
RPS18	9933
RPS17	9887
RPS27A	9825
RPS3A	9711
GEMIN6	9260
SNRPD1	9167
RPS8	9139
RPS24	9103
RPS15A	9099
RPS20	9095
GEMIN8	9012
RPS10	8891
RPS25	8697
SNRPE	8634
RPS6	8554
RPS21	8505
RPS13	8223
RPS2	8087
GEMIN7	7918
RPS9	7840
RPSA	7817
SNRPD2	7813
RPS5	7781
RPS19	7746
RPS26	7632
RPS27	7601
RPS7	7537
FAU	7371
SNRPG	7111
RPS15	6970
RPS3	6946
RPS23	6844
RPS29	6557
SNRPD3	6169
RPS16	6014
RPS11	5918
RPS14	5824
SNRPB	5683
RPS28	5156
SNRPF	5137
RPS4X	4506
GEMIN2	2443
GEMIN4	1680
RPS4Y1	1386
GEMIN5	992
RPS27L	783
SMN1	-4743
DDX20	-7175

---

YAP1- and WWTR1 (TAZ)-stimulated gene expression

set	YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize	7
pANOVA	0.00992
s.dist	-0.563
p.adjustANOVA	0.059

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HIPK2	-10491
RUNX2	-9852
HIPK1	-9258
KAT2B	-7637
NPPA	-7464
WWTR1	-5454
TEAD2	9714

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HIPK2	-10491
RUNX2	-9852
HIPK1	-9258
KAT2B	-7637
NPPA	-7464
WWTR1	-5454
TEAD2	9714

---

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

set	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
setSize	9
pANOVA	0.00346
s.dist	-0.563
p.adjustANOVA	0.026

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CR1	-9866
CTLA4	-9822
IL2RA	-9712
RUNX1	-8625
FOXP3	-7281
CBFB	-7090
TNFRSF18	-6931
NFATC2	-2567
IFNG	9915

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CR1	-9866
CTLA4	-9822
IL2RA	-9712
RUNX1	-8625
FOXP3	-7281
CBFB	-7090
TNFRSF18	-6931
NFATC2	-2567
IFNG	9915

---

Folding of actin by CCT/TriC

set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.00215
s.dist	0.56
p.adjustANOVA	0.0174

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCT8	9671
CCT4	9131
CCT2	8232
CCT7	8096
CCT6A	7589
TCP1	7397
CCT3	5679
CCT5	3960
CCT6B	3748
ACTB	2225

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCT8	9671
CCT4	9131
CCT2	8232
CCT7	8096
CCT6A	7589
TCP1	7397
CCT3	5679
CCT5	3960
CCT6B	3748
ACTB	2225

---

Defective binding of VWF variant to GPIb:IX:V

set	Defective binding of VWF variant to GPIb:IX:V
setSize	7
pANOVA	0.0122
s.dist	-0.547
p.adjustANOVA	0.0701

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GP9	-8954
GP1BB	-8225
VWF	-7561
COL1A2	-6106
COL1A1	-5424
GP1BA	-4437
GP5	1490

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GP9	-8954
GP1BB	-8225
VWF	-7561
COL1A2	-6106
COL1A1	-5424
GP1BA	-4437
GP5	1490

---

Enhanced binding of GP1BA variant to VWF multimer:collagen

set	Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize	7
pANOVA	0.0122
s.dist	-0.547
p.adjustANOVA	0.0701

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GP9	-8954
GP1BB	-8225
VWF	-7561
COL1A2	-6106
COL1A1	-5424
GP1BA	-4437
GP5	1490

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GP9	-8954
GP1BB	-8225
VWF	-7561
COL1A2	-6106
COL1A1	-5424
GP1BA	-4437
GP5	1490

---

SRP-dependent cotranslational protein targeting to membrane

set	SRP-dependent cotranslational protein targeting to membrane
setSize	111
pANOVA	3.25e-23
s.dist	0.545
p.adjustANOVA	4.18e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	10613
RPL13	10383
RPS12	10230
RPL9	10058
RPL12	10025
RPLP1	9941
RPS18	9933
RPS17	9887
RPL34	9856
RPS27A	9825
RPL39L	9782
RPS3A	9711
RPLP2	9685
RPL21	9603
RPL17	9587
RPL23	9567
RPL26	9327
RPL31	9298
RPL36A	9235
RPL35	9142
RPL22	9140
RPS8	9139
RPL7	9116
RPS24	9103
RPS15A	9099
RPS20	9095
RPL5	9017
RPL14	8938
RPS10	8891
RPL19	8790
RPL23A	8722
RPS25	8697
SRP68	8658
RPL10	8605
RPS6	8554
RPS21	8505
RPL36	8426
RPL3	8393
RPL6	8370
RPL11	8337
RPL27	8261
RPS13	8223
RPL24	8206
SEC11A	8190
RPL18	8165
RPS2	8087
RPL10A	8084
RPL29	8063
RPL4	8005
RPL13A	7954
SRP19	7940
RPS9	7840
RPSA	7817
RPL38	7791
RPS5	7781
RPL30	7765
RPS19	7746
RPL35A	7642
RPS26	7632
RPL7A	7615
RPS27	7601
RPL39	7600
RPS7	7537
FAU	7371
RPL18A	7350
RPL37A	7333
RPS15	6970
RPS3	6946
SSR2	6932
RPL32	6857
RPS23	6844
RPLP0	6805
RPS29	6557
RPL41	6420
RPL3L	6204
SRP14	6126
RPL26L1	6051
RPS16	6014
RPS11	5918
RPL37	5913
RPS14	5824
RPL8	5366
RPL15	5305
RPS28	5156
SEC61G	4895
RPL28	4613
RPS4X	4506
RPN2	3920
SRP9	3676
UBA52	3287
SSR4	3189
SSR1	3177
SRPRB	3053
SEC61B	2984
SEC11C	2841
SRPRA	2021
RPL22L1	2000
RPS4Y1	1386
SPCS1	1132
DDOST	1039
RPS27L	783
RPN1	633
SEC61A2	289
SRP54	-1346
RPL36AL	-1886
SPCS2	-1893
SRP72	-2981
SSR3	-4004
SEC61A1	-4484
TRAM1	-6306
SPCS3	-6329

---

Tandem pore domain potassium channels

set	Tandem pore domain potassium channels
setSize	5
pANOVA	0.0355
s.dist	0.543
p.adjustANOVA	0.148

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KCNK10	11105
KCNK6	10448
KCNK17	5233
KCNK7	2947
KCNK13	2175

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KCNK10	11105
KCNK6	10448
KCNK17	5233
KCNK7	2947
KCNK13	2175

---

Sperm Motility And Taxes

set	Sperm Motility And Taxes
setSize	6
pANOVA	0.022
s.dist	0.54
p.adjustANOVA	0.106

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HVCN1	10092
CATSPER2	9371
CATSPERG	8332
CATSPERB	6411
CATSPER1	5509
CATSPER3	-1632

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HVCN1	10092
CATSPER2	9371
CATSPERG	8332
CATSPERB	6411
CATSPER1	5509
CATSPER3	-1632

---

Classical antibody-mediated complement activation

set	Classical antibody-mediated complement activation
setSize	69
pANOVA	1.06e-14
s.dist	-0.538
p.adjustANOVA	5.83e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGKV2-29	-10267
IGLV1-44	-10148
IGHV4-34	-9842
IGKV2-30	-9449
IGHV3-13	-9447
IGLC3	-9397
IGHV2-5	-9376
IGLV7-46	-9362
IGLV1-51	-9135
IGLV4-69	-8985
IGHV2-70	-8943
IGHV3-33	-8905
IGLC7	-8897
IGHV3-23	-8863
IGLV7-43	-8854
IGLV2-23	-8808
IGKV3-15	-8768
IGLC1	-8742
IGKV1-33	-8710
IGHV3-7	-8648

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGKV2-29	-10267
IGLV1-44	-10148
IGHV4-34	-9842
IGKV2-30	-9449
IGHV3-13	-9447
IGLC3	-9397
IGHV2-5	-9376
IGLV7-46	-9362
IGLV1-51	-9135
IGLV4-69	-8985
IGHV2-70	-8943
IGHV3-33	-8905
IGLC7	-8897
IGHV3-23	-8863
IGLV7-43	-8854
IGLV2-23	-8808
IGKV3-15	-8768
IGLC1	-8742
IGKV1-33	-8710
IGHV3-7	-8648
IGKC	-8511
IGLC2	-8389
IGHV4-59	-8270
IGHV1-2	-7935
IGLV2-8	-7928
IGHV1-69	-7877
IGLV10-54	-7749
IGKV2-28	-7694
IGKV1D-39	-7513
IGLV3-19	-7506
IGHV1-46	-7443
IGKV1-5	-7302
IGLV8-61	-6696
IGLV1-40	-6608
IGLV1-47	-6100
IGKV2D-28	-5947
IGHV3-30	-5936
IGLV2-18	-5566
IGKV1-16	-5500
IGKV4-1	-5327
IGKV3-11	-5171
IGLV2-11	-5095
IGHV3-11	-5045
C1QB	-5038
IGHG2	-4907
IGLV6-57	-4869
IGKV3-20	-4791
IGLV3-25	-4770
IGKV1-17	-4621
IGHV3-53	-4521
IGLV3-27	-3958
IGLV3-1	-3878
C1QC	-3599
IGHV4-39	-3479
IGHG3	-3393
IGHG1	-2873
IGLV5-45	-2748
IGLV3-21	-2421
IGLV2-14	-1743
IGLV4-60	-590
IGKV3D-20	-150
IGKV1-12	-95
C1QA	103
IGLV1-36	556
IGHV3-48	720
C1S	805
IGHG4	1839
C1R	9906
IGLV3-12	10526

---

Proton-coupled monocarboxylate transport

set	Proton-coupled monocarboxylate transport
setSize	6
pANOVA	0.0226
s.dist	-0.538
p.adjustANOVA	0.108

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC16A8	-10073
SLC16A1	-7705
EMB	-6689
SLC16A3	-4844
SLC16A7	-4752
BSG	1065

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC16A8	-10073
SLC16A1	-7705
EMB	-6689
SLC16A3	-4844
SLC16A7	-4752
BSG	1065

---

Aryl hydrocarbon receptor signalling

set	Aryl hydrocarbon receptor signalling
setSize	6
pANOVA	0.0232
s.dist	0.535
p.adjustANOVA	0.11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AIP	10079
AHRR	10003
HSP90AB1	8680
PTGES3	8303
ARNT	7672
AHR	-6961

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AIP	10079
AHRR	10003
HSP90AB1	8680
PTGES3	8303
ARNT	7672
AHR	-6961

---

FASTK family proteins regulate processing and stability of mitochondrial RNAs

set	FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize	19
pANOVA	5.47e-05
s.dist	-0.535
p.adjustANOVA	0.000771

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND1	-9783
MT-ND4	-9171
MT-ND2	-9083
MT-RNR1	-8725
MT-ND5	-8669
MT-CYB	-8456
MT-ATP6	-8326
MT-RNR2	-8106
MT-ND3	-7827
MT-ND4L	-7725
TBRG4	-6651
MT-CO3	-5571
MT-ND6	-4967
MT-CO2	-4834
MT-CO1	-3754
FASTKD5	-3238
MT-ATP8	-1808
FASTK	5970
FASTKD2	6908

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND1	-9783
MT-ND4	-9171
MT-ND2	-9083
MT-RNR1	-8725
MT-ND5	-8669
MT-CYB	-8456
MT-ATP6	-8326
MT-RNR2	-8106
MT-ND3	-7827
MT-ND4L	-7725
TBRG4	-6651
MT-CO3	-5571
MT-ND6	-4967
MT-CO2	-4834
MT-CO1	-3754
FASTKD5	-3238
MT-ATP8	-1808
FASTK	5970
FASTKD2	6908

---

Inactivation of CDC42 and RAC1

set	Inactivation of CDC42 and RAC1
setSize	7
pANOVA	0.0143
s.dist	-0.534
p.adjustANOVA	0.0798

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SRGAP2	-10562
SRGAP1	-10546
CDC42	-6903
SRGAP3	-6865
ARHGAP39	-4444
ROBO1	-4090
RAC1	5149

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SRGAP2	-10562
SRGAP1	-10546
CDC42	-6903
SRGAP3	-6865
ARHGAP39	-4444
ROBO1	-4090
RAC1	5149

---

Protein repair

set	Protein repair
setSize	6
pANOVA	0.0238
s.dist	-0.533
p.adjustANOVA	0.112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MSRB3	-9959
MSRB2	-8528
MSRB1	-6904
TXN	-3678
MSRA	-3428
PCMT1	-196

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MSRB3	-9959
MSRB2	-8528
MSRB1	-6904
TXN	-3678
MSRA	-3428
PCMT1	-196

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report