date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -1.3629661
A1BG -0.2722587
A1BG-AS1 0.1518141
A1CF 1.8976512
A2M -0.6716715
A2M-AS1 -1.0775297

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21870
duplicated_genes_present 0
num_profile_genes_in_sets 8802
num_profile_genes_not_in_sets 13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1189
num_genesets_included 1536

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Biosynthesis of EPA-derived SPMs 6 2.57e-04 -0.862 4.39e-03
Biosynthesis of Lipoxins (LX) 6 3.34e-04 -0.846 5.25e-03
Biosynthesis of E-series 18(S)-resolvins 5 1.17e-03 -0.838 1.35e-02
Protein repair 6 9.25e-04 -0.781 1.15e-02
Cross-presentation of particulate exogenous antigens (phagosomes) 8 2.06e-04 -0.758 3.64e-03
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.71e-03 -0.707 2.41e-02
MECP2 regulates transcription of neuronal ligands 5 7.04e-03 0.696 5.24e-02
Synthesis of 5-eicosatetraenoic acids 7 1.55e-03 -0.691 1.65e-02
Fructose catabolism 5 1.04e-02 -0.662 6.69e-02
Synthesis of 12-eicosatetraenoic acid derivatives 6 5.06e-03 -0.661 4.00e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.27e-03 0.658 1.41e-02
Signal attenuation 9 6.86e-04 -0.653 9.06e-03
Interleukin-21 signaling 9 1.17e-03 0.625 1.35e-02
OAS antiviral response 8 2.57e-03 0.616 2.31e-02
Acetylcholine binding and downstream events 5 1.86e-02 0.608 1.02e-01
Postsynaptic nicotinic acetylcholine receptors 5 1.86e-02 0.608 1.02e-01
Defective LFNG causes SCDO3 5 2.67e-02 0.572 1.29e-01
Histidine catabolism 7 8.89e-03 -0.571 6.12e-02
NFE2L2 regulating inflammation associated genes 5 2.71e-02 0.571 1.31e-01
Keratan sulfate degradation 9 3.19e-03 -0.568 2.75e-02
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.02e-02 -0.561 6.60e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.07e-02 0.557 6.77e-02
Antimicrobial peptides 34 1.86e-08 -0.557 1.43e-06
Replacement of protamines by nucleosomes in the male pronucleus 13 5.31e-04 -0.555 7.46e-03
Diseases of Mismatch Repair (MMR) 5 3.22e-02 0.553 1.48e-01
Sulfide oxidation to sulfate 5 3.35e-02 -0.549 1.52e-01
Cohesin Loading onto Chromatin 10 2.66e-03 0.549 2.38e-02
RNA Polymerase I Promoter Opening 17 9.24e-05 -0.548 2.28e-03
Metabolism of Angiotensinogen to Angiotensins 12 1.07e-03 -0.545 1.27e-02
Mitotic Telophase/Cytokinesis 13 9.16e-04 0.531 1.15e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.50e-02 -0.528 1.23e-01
Fibronectin matrix formation 6 2.66e-02 -0.523 1.29e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.10e-04 -0.523 9.30e-03
Axonal growth inhibition (RHOA activation) 7 1.76e-02 -0.518 9.83e-02
p75NTR regulates axonogenesis 7 1.76e-02 -0.518 9.83e-02
Prostanoid ligand receptors 8 1.15e-02 -0.516 7.07e-02
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.81e-02 0.516 1.00e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 5.19e-07 0.513 2.97e-05
HDL remodeling 6 3.01e-02 0.511 1.41e-01
HDR through MMEJ (alt-NHEJ) 12 2.45e-03 0.505 2.23e-02
Induction of Cell-Cell Fusion 8 1.37e-02 -0.503 8.10e-02
TGFBR3 expression 20 1.03e-04 0.502 2.48e-03
Common Pathway of Fibrin Clot Formation 13 1.77e-03 -0.501 1.82e-02
Linoleic acid (LA) metabolism 7 2.23e-02 -0.499 1.14e-01
Modulation by Mtb of host immune system 7 2.25e-02 -0.498 1.15e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.50e-02 0.497 8.75e-02
Regulation of NPAS4 mRNA translation 8 1.50e-02 0.497 8.75e-02
Relaxin receptors 5 5.47e-02 -0.496 2.11e-01
Phosphate bond hydrolysis by NTPDase proteins 5 5.72e-02 0.491 2.18e-01
Regulation of NPAS4 gene expression 11 5.12e-03 0.487 4.03e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Biosynthesis of EPA-derived SPMs 6 2.57e-04 -8.62e-01 4.39e-03
Biosynthesis of Lipoxins (LX) 6 3.34e-04 -8.46e-01 5.25e-03
Biosynthesis of E-series 18(S)-resolvins 5 1.17e-03 -8.38e-01 1.35e-02
Protein repair 6 9.25e-04 -7.81e-01 1.15e-02
Cross-presentation of particulate exogenous antigens (phagosomes) 8 2.06e-04 -7.58e-01 3.64e-03
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.71e-03 -7.07e-01 2.41e-02
MECP2 regulates transcription of neuronal ligands 5 7.04e-03 6.96e-01 5.24e-02
Synthesis of 5-eicosatetraenoic acids 7 1.55e-03 -6.91e-01 1.65e-02
Fructose catabolism 5 1.04e-02 -6.62e-01 6.69e-02
Synthesis of 12-eicosatetraenoic acid derivatives 6 5.06e-03 -6.61e-01 4.00e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.27e-03 6.58e-01 1.41e-02
Signal attenuation 9 6.86e-04 -6.53e-01 9.06e-03
Interleukin-21 signaling 9 1.17e-03 6.25e-01 1.35e-02
OAS antiviral response 8 2.57e-03 6.16e-01 2.31e-02
Acetylcholine binding and downstream events 5 1.86e-02 6.08e-01 1.02e-01
Postsynaptic nicotinic acetylcholine receptors 5 1.86e-02 6.08e-01 1.02e-01
Defective LFNG causes SCDO3 5 2.67e-02 5.72e-01 1.29e-01
Histidine catabolism 7 8.89e-03 -5.71e-01 6.12e-02
NFE2L2 regulating inflammation associated genes 5 2.71e-02 5.71e-01 1.31e-01
Keratan sulfate degradation 9 3.19e-03 -5.68e-01 2.75e-02
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.02e-02 -5.61e-01 6.60e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.07e-02 5.57e-01 6.77e-02
Antimicrobial peptides 34 1.86e-08 -5.57e-01 1.43e-06
Replacement of protamines by nucleosomes in the male pronucleus 13 5.31e-04 -5.55e-01 7.46e-03
Diseases of Mismatch Repair (MMR) 5 3.22e-02 5.53e-01 1.48e-01
Sulfide oxidation to sulfate 5 3.35e-02 -5.49e-01 1.52e-01
Cohesin Loading onto Chromatin 10 2.66e-03 5.49e-01 2.38e-02
RNA Polymerase I Promoter Opening 17 9.24e-05 -5.48e-01 2.28e-03
Metabolism of Angiotensinogen to Angiotensins 12 1.07e-03 -5.45e-01 1.27e-02
Mitotic Telophase/Cytokinesis 13 9.16e-04 5.31e-01 1.15e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.50e-02 -5.28e-01 1.23e-01
Fibronectin matrix formation 6 2.66e-02 -5.23e-01 1.29e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.10e-04 -5.23e-01 9.30e-03
Axonal growth inhibition (RHOA activation) 7 1.76e-02 -5.18e-01 9.83e-02
p75NTR regulates axonogenesis 7 1.76e-02 -5.18e-01 9.83e-02
Prostanoid ligand receptors 8 1.15e-02 -5.16e-01 7.07e-02
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.81e-02 5.16e-01 1.00e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 5.19e-07 5.13e-01 2.97e-05
HDL remodeling 6 3.01e-02 5.11e-01 1.41e-01
HDR through MMEJ (alt-NHEJ) 12 2.45e-03 5.05e-01 2.23e-02
Induction of Cell-Cell Fusion 8 1.37e-02 -5.03e-01 8.10e-02
TGFBR3 expression 20 1.03e-04 5.02e-01 2.48e-03
Common Pathway of Fibrin Clot Formation 13 1.77e-03 -5.01e-01 1.82e-02
Linoleic acid (LA) metabolism 7 2.23e-02 -4.99e-01 1.14e-01
Modulation by Mtb of host immune system 7 2.25e-02 -4.98e-01 1.15e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.50e-02 4.97e-01 8.75e-02
Regulation of NPAS4 mRNA translation 8 1.50e-02 4.97e-01 8.75e-02
Relaxin receptors 5 5.47e-02 -4.96e-01 2.11e-01
Phosphate bond hydrolysis by NTPDase proteins 5 5.72e-02 4.91e-01 2.18e-01
Regulation of NPAS4 gene expression 11 5.12e-03 4.87e-01 4.03e-02
Activation of RAS in B cells 5 6.29e-02 4.80e-01 2.34e-01
RUNX3 Regulates Immune Response and Cell Migration 5 6.33e-02 -4.80e-01 2.35e-01
Post-transcriptional silencing by small RNAs 7 3.12e-02 4.70e-01 1.45e-01
Fructose metabolism 7 3.13e-02 -4.70e-01 1.45e-01
Establishment of Sister Chromatid Cohesion 11 7.29e-03 4.67e-01 5.36e-02
Assembly of active LPL and LIPC lipase complexes 10 1.10e-02 -4.64e-01 6.95e-02
ALK mutants bind TKIs 11 7.89e-03 4.63e-01 5.72e-02
Diseases associated with surfactant metabolism 5 8.14e-02 -4.50e-01 2.79e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 7.07e-03 -4.49e-01 5.24e-02
Transport of connexons to the plasma membrane 12 7.07e-03 -4.49e-01 5.24e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 5.12e-04 -4.49e-01 7.33e-03
CD163 mediating an anti-inflammatory response 9 2.00e-02 -4.48e-01 1.07e-01
ROBO receptors bind AKAP5 7 4.04e-02 4.47e-01 1.72e-01
Scavenging by Class F Receptors 5 8.33e-02 4.47e-01 2.82e-01
LTC4-CYSLTR mediated IL4 production 5 8.42e-02 4.46e-01 2.84e-01
Regulation of NFE2L2 gene expression 8 2.97e-02 4.44e-01 1.39e-01
Synthesis of PIPs at the early endosome membrane 16 2.13e-03 4.43e-01 2.04e-02
RORA activates gene expression 18 1.14e-03 4.43e-01 1.33e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.47e-05 4.42e-01 5.45e-04
FGFR3 ligand binding and activation 5 8.72e-02 4.42e-01 2.89e-01
FGFR3c ligand binding and activation 5 8.72e-02 4.42e-01 2.89e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 2.26e-03 -4.41e-01 2.11e-02
p75NTR recruits signalling complexes 12 8.32e-03 -4.40e-01 5.92e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.71e-05 4.39e-01 5.82e-04
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.71e-05 4.39e-01 5.82e-04
Interleukin-9 signaling 8 3.24e-02 4.37e-01 1.49e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 4.62e-02 4.35e-01 1.88e-01
Erythrocytes take up oxygen and release carbon dioxide 7 4.65e-02 -4.34e-01 1.88e-01
Uptake of dietary cobalamins into enterocytes 6 6.58e-02 4.34e-01 2.38e-01
Disorders of Developmental Biology 12 9.31e-03 4.34e-01 6.27e-02
Disorders of Nervous System Development 12 9.31e-03 4.34e-01 6.27e-02
Loss of function of MECP2 in Rett syndrome 12 9.31e-03 4.34e-01 6.27e-02
Pervasive developmental disorders 12 9.31e-03 4.34e-01 6.27e-02
Defective binding of VWF variant to GPIb:IX:V 6 6.66e-02 -4.32e-01 2.40e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 6 6.66e-02 -4.32e-01 2.40e-01
Defective factor IX causes hemophilia B 6 6.79e-02 -4.30e-01 2.43e-01
NR1H2 and NR1H3-mediated signaling 38 5.16e-06 4.27e-01 2.21e-04
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.06e-02 -4.26e-01 6.74e-02
Vpr-mediated nuclear import of PICs 34 1.70e-05 4.26e-01 5.82e-04
Formation of ATP by chemiosmotic coupling 20 1.11e-03 -4.21e-01 1.30e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.00e-02 -4.18e-01 1.41e-01
Diseases of hemostasis 14 7.18e-03 -4.15e-01 5.30e-02
CYP2E1 reactions 5 1.12e-01 4.11e-01 3.35e-01
Activation of BAD and translocation to mitochondria 15 5.87e-03 -4.11e-01 4.50e-02
Activation of RAC1 downstream of NMDARs 7 6.04e-02 -4.10e-01 2.28e-01
RHO GTPases Activate NADPH Oxidases 22 1.02e-03 -4.04e-01 1.23e-02
Erythrocytes take up carbon dioxide and release oxygen 11 2.04e-02 -4.04e-01 1.08e-01
O2/CO2 exchange in erythrocytes 11 2.04e-02 -4.04e-01 1.08e-01
Post-chaperonin tubulin folding pathway 18 3.06e-03 -4.03e-01 2.66e-02
Interferon alpha/beta signaling 64 2.94e-08 4.01e-01 2.18e-06
Regulation of MECP2 expression and activity 29 1.90e-04 4.00e-01 3.48e-03
Crosslinking of collagen fibrils 13 1.33e-02 -3.97e-01 7.89e-02
Regulation of ornithine decarboxylase (ODC) 38 2.39e-05 -3.96e-01 7.95e-04
Zygotic genome activation (ZGA) 5 1.26e-01 3.95e-01 3.60e-01
DNA methylation 18 3.95e-03 -3.92e-01 3.29e-02
The canonical retinoid cycle in rods (twilight vision) 9 4.23e-02 -3.91e-01 1.77e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.06e-04 3.90e-01 2.50e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.97e-02 -3.89e-01 1.06e-01
alpha-linolenic acid (ALA) metabolism 12 1.97e-02 -3.89e-01 1.06e-01
PI-3K cascade:FGFR4 11 2.57e-02 3.88e-01 1.26e-01
SUMOylation of SUMOylation proteins 35 7.05e-05 3.88e-01 2.00e-03
Response to metal ions 6 9.98e-02 -3.88e-01 3.11e-01
Signaling by FLT3 fusion proteins 18 4.39e-03 3.88e-01 3.57e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 2.62e-02 -3.87e-01 1.28e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.79e-04 3.83e-01 3.42e-03
Synthesis of pyrophosphates in the cytosol 8 6.14e-02 3.82e-01 2.30e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 3.95e-03 -3.82e-01 3.29e-02
STAT3 nuclear events downstream of ALK signaling 11 2.86e-02 3.81e-01 1.36e-01
NS1 Mediated Effects on Host Pathways 40 3.05e-05 3.81e-01 9.96e-04
PDH complex synthesizes acetyl-CoA from PYR 5 1.42e-01 -3.79e-01 3.85e-01
Formation of Fibrin Clot (Clotting Cascade) 26 8.19e-04 -3.79e-01 1.07e-02
Postmitotic nuclear pore complex (NPC) reformation 27 6.60e-04 3.79e-01 8.77e-03
Bicarbonate transporters 9 4.99e-02 3.78e-01 1.98e-01
Defects of platelet adhesion to exposed collagen 7 8.39e-02 -3.77e-01 2.83e-01
PI-3K cascade:FGFR3 10 3.89e-02 3.77e-01 1.66e-01
Digestion 5 1.45e-01 -3.77e-01 3.90e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 7.38e-05 -3.76e-01 2.05e-03
Pyrimidine salvage 10 3.93e-02 -3.76e-01 1.68e-01
Mucopolysaccharidoses 11 3.09e-02 -3.76e-01 1.44e-01
Nuclear import of Rev protein 34 1.49e-04 3.76e-01 3.08e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 3.20e-02 3.73e-01 1.47e-01
Phosphorylation of Emi1 6 1.14e-01 3.73e-01 3.38e-01
Defensins 8 6.93e-02 -3.71e-01 2.47e-01
SUMO is proteolytically processed 6 1.16e-01 3.71e-01 3.42e-01
Amyloid fiber formation 51 4.59e-06 -3.71e-01 2.01e-04
Interleukin-18 signaling 6 1.17e-01 -3.70e-01 3.42e-01
CS/DS degradation 9 5.52e-02 -3.69e-01 2.12e-01
Hyaluronan uptake and degradation 12 2.72e-02 -3.68e-01 1.31e-01
Recycling of eIF2:GDP 8 7.21e-02 -3.67e-01 2.54e-01
HDMs demethylate histones 22 2.87e-03 3.67e-01 2.54e-02
Transport of the SLBP independent Mature mRNA 35 1.82e-04 3.65e-01 3.44e-03
Eicosanoids 8 7.41e-02 -3.65e-01 2.60e-01
Degradation of DVL 43 3.63e-05 -3.64e-01 1.17e-03
Interactions of Rev with host cellular proteins 37 1.30e-04 3.63e-01 2.79e-03
Hydrolysis of LPC 8 7.51e-02 -3.63e-01 2.63e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.64e-04 3.63e-01 3.29e-03
Peptide chain elongation 87 5.68e-09 -3.61e-01 6.84e-07
Ubiquitin-dependent degradation of Cyclin D 39 1.05e-04 -3.59e-01 2.49e-03
Signaling by cytosolic FGFR1 fusion mutants 18 8.41e-03 3.59e-01 5.96e-02
FGFR4 ligand binding and activation 5 1.66e-01 3.58e-01 4.29e-01
Activation of the AP-1 family of transcription factors 10 5.00e-02 -3.58e-01 1.98e-01
Pentose phosphate pathway 13 2.57e-02 -3.57e-01 1.26e-01
Rev-mediated nuclear export of HIV RNA 35 2.54e-04 3.57e-01 4.37e-03
TRAF3-dependent IRF activation pathway 13 2.62e-02 3.56e-01 1.28e-01
Anchoring fibril formation 8 8.17e-02 -3.55e-01 2.79e-01
Synthesis of GDP-mannose 6 1.32e-01 -3.55e-01 3.68e-01
Vif-mediated degradation of APOBEC3G 41 8.48e-05 -3.55e-01 2.24e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 3.56e-07 -3.54e-01 2.28e-05
Digestion and absorption 7 1.05e-01 -3.54e-01 3.23e-01
RHO GTPases activate IQGAPs 25 2.20e-03 -3.54e-01 2.08e-02
IFNG signaling activates MAPKs 8 8.34e-02 -3.54e-01 2.82e-01
RUNX1 regulates expression of components of tight junctions 5 1.71e-01 -3.53e-01 4.36e-01
Heme signaling 45 4.16e-05 3.53e-01 1.29e-03
Growth hormone receptor signaling 20 6.28e-03 -3.53e-01 4.77e-02
SARS-CoV-1 modulates host translation machinery 36 2.49e-04 -3.53e-01 4.33e-03
Processive synthesis on the C-strand of the telomere 19 7.86e-03 3.52e-01 5.71e-02
Advanced glycosylation endproduct receptor signaling 12 3.48e-02 -3.52e-01 1.56e-01
Synthesis of PIPs at the late endosome membrane 11 4.34e-02 3.52e-01 1.81e-01
Metabolism of polyamines 46 3.76e-05 -3.51e-01 1.19e-03
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.25e-04 -3.51e-01 5.18e-03
Germ layer formation at gastrulation 9 6.89e-02 3.50e-01 2.46e-01
Viral mRNA Translation 87 1.81e-08 -3.49e-01 1.43e-06
SUMOylation of ubiquitinylation proteins 39 1.62e-04 3.49e-01 3.29e-03
Transport of the SLBP Dependant Mature mRNA 36 2.93e-04 3.49e-01 4.91e-03
Biosynthesis of specialized proresolving mediators (SPMs) 16 1.58e-02 -3.48e-01 9.12e-02
Regulation of Apoptosis 40 1.38e-04 -3.48e-01 2.90e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.74e-04 -3.47e-01 3.34e-03
p53-Independent DNA Damage Response 39 1.74e-04 -3.47e-01 3.34e-03
p53-Independent G1/S DNA damage checkpoint 39 1.74e-04 -3.47e-01 3.34e-03
Eukaryotic Translation Elongation 92 1.00e-08 -3.46e-01 1.02e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 2.90e-09 -3.45e-01 4.00e-07
Glutamate and glutamine metabolism 12 3.87e-02 -3.45e-01 1.66e-01
Glutathione conjugation 27 2.09e-03 -3.42e-01 2.03e-02
Interactions of Vpr with host cellular proteins 37 3.45e-04 3.40e-01 5.27e-03
Signaling by PDGFR in disease 19 1.04e-02 3.40e-01 6.68e-02
Detoxification of Reactive Oxygen Species 30 1.34e-03 -3.38e-01 1.46e-02
Impaired BRCA2 binding to PALB2 24 4.15e-03 3.38e-01 3.42e-02
Propionyl-CoA catabolism 5 1.91e-01 3.37e-01 4.64e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.85e-04 -3.37e-01 3.46e-03
mRNA Editing 8 9.87e-02 3.37e-01 3.10e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 5.21e-03 -3.37e-01 4.06e-02
Signaling by FGFR4 in disease 11 5.34e-02 3.36e-01 2.09e-01
Formation of a pool of free 40S subunits 99 7.43e-09 -3.36e-01 7.95e-07
Killing mechanisms 10 6.58e-02 -3.36e-01 2.38e-01
WNT5:FZD7-mediated leishmania damping 10 6.58e-02 -3.36e-01 2.38e-01
Hedgehog ligand biogenesis 47 6.86e-05 -3.36e-01 1.97e-03
Vpu mediated degradation of CD4 39 3.13e-04 -3.34e-01 5.03e-03
Arachidonate metabolism 47 7.66e-05 -3.33e-01 2.08e-03
PI-3K cascade:FGFR2 13 3.74e-02 3.33e-01 1.63e-01
Regulation of RUNX3 expression and activity 45 1.10e-04 -3.33e-01 2.54e-03
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.06e-09 -3.32e-01 3.05e-07
Complex I biogenesis 66 3.16e-06 -3.32e-01 1.49e-04
Maturation of protein 3a 9683673 9 8.53e-02 3.31e-01 2.85e-01
Maturation of protein 3a 9694719 9 8.53e-02 3.31e-01 2.85e-01
Biosynthesis of maresins 6 1.60e-01 3.31e-01 4.20e-01
Phenylalanine and tyrosine metabolism 9 8.55e-02 -3.31e-01 2.85e-01
Degradation of cysteine and homocysteine 12 4.73e-02 -3.31e-01 1.91e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 4.45e-04 -3.29e-01 6.45e-03
Hyaluronan metabolism 15 2.79e-02 -3.28e-01 1.34e-01
SUMOylation of DNA replication proteins 46 1.22e-04 3.27e-01 2.72e-03
Glycosphingolipid catabolism 31 1.61e-03 -3.27e-01 1.70e-02
RHO GTPases Activate Rhotekin and Rhophilins 8 1.10e-01 -3.27e-01 3.31e-01
Cap-dependent Translation Initiation 117 1.06e-09 -3.26e-01 1.71e-07
Eukaryotic Translation Initiation 117 1.06e-09 -3.26e-01 1.71e-07
Sphingolipid catabolism 11 6.11e-02 -3.26e-01 2.29e-01
Urea cycle 7 1.35e-01 -3.26e-01 3.75e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 9.09e-02 -3.25e-01 2.94e-01
Phospholipase C-mediated cascade; FGFR4 6 1.68e-01 3.25e-01 4.32e-01
RHO GTPases activate PKNs 46 1.36e-04 -3.25e-01 2.88e-03
Transport of nucleotide sugars 9 9.15e-02 -3.25e-01 2.94e-01
Passive transport by Aquaporins 6 1.68e-01 -3.25e-01 4.33e-01
Eicosanoid ligand-binding receptors 13 4.33e-02 -3.24e-01 1.81e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 4.57e-09 -3.23e-01 5.87e-07
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 2.87e-04 -3.23e-01 4.86e-03
Cardiogenesis 14 3.64e-02 3.23e-01 1.59e-01
Sensing of DNA Double Strand Breaks 6 1.71e-01 3.23e-01 4.36e-01
RUNX2 regulates osteoblast differentiation 19 1.50e-02 -3.22e-01 8.75e-02
Hh mutants are degraded by ERAD 42 3.05e-04 -3.22e-01 4.99e-03
Removal of the Flap Intermediate from the C-strand 17 2.19e-02 3.21e-01 1.14e-01
Signaling by FGFR3 in disease 14 3.77e-02 3.21e-01 1.63e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 1.74e-01 3.21e-01 4.40e-01
Neutrophil degranulation 456 8.32e-32 -3.20e-01 1.60e-28
E2F-enabled inhibition of pre-replication complex formation 9 9.63e-02 3.20e-01 3.04e-01
Impaired BRCA2 binding to RAD51 35 1.09e-03 3.19e-01 1.28e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 1.18e-01 -3.19e-01 3.43e-01
The activation of arylsulfatases 10 8.12e-02 -3.18e-01 2.79e-01
Telomere C-strand synthesis initiation 13 4.76e-02 3.17e-01 1.92e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.20e-01 -3.17e-01 4.98e-01
TRAF6 mediated IRF7 activation 15 3.41e-02 3.16e-01 1.54e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 1.22e-02 -3.16e-01 7.41e-02
Neurodegenerative Diseases 21 1.22e-02 -3.16e-01 7.41e-02
Signalling to RAS 19 1.72e-02 -3.16e-01 9.64e-02
Hh mutants abrogate ligand secretion 43 3.41e-04 -3.16e-01 5.26e-03
Regulation of PTEN mRNA translation 13 4.90e-02 3.15e-01 1.96e-01
RAS processing 23 9.15e-03 -3.14e-01 6.25e-02
Defective CFTR causes cystic fibrosis 47 2.02e-04 -3.13e-01 3.60e-03
p75NTR signals via NF-kB 15 3.61e-02 -3.13e-01 1.59e-01
NF-kB is activated and signals survival 12 6.18e-02 -3.11e-01 2.31e-01
Negative regulation of NOTCH4 signaling 44 3.52e-04 -3.11e-01 5.33e-03
SRP-dependent cotranslational protein targeting to membrane 110 1.69e-08 -3.11e-01 1.43e-06
Recycling of bile acids and salts 10 8.94e-02 3.10e-01 2.92e-01
RHOT1 GTPase cycle 5 2.31e-01 -3.09e-01 5.14e-01
Cristae formation 33 2.16e-03 -3.09e-01 2.05e-02
Eukaryotic Translation Termination 91 3.66e-07 -3.08e-01 2.28e-05
Acyl chain remodeling of CL 5 2.33e-01 -3.08e-01 5.16e-01
Signaling by MAPK mutants 6 1.91e-01 -3.08e-01 4.64e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.34e-05 -3.08e-01 1.33e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.28e-04 -3.07e-01 2.79e-03
Aggrephagy 34 1.95e-03 -3.07e-01 1.92e-02
Heme degradation 10 9.30e-02 -3.07e-01 2.98e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 1.53e-04 -3.06e-01 3.15e-03
Selenocysteine synthesis 91 4.41e-07 -3.06e-01 2.66e-05
Glycogen breakdown (glycogenolysis) 13 5.61e-02 -3.06e-01 2.15e-01
Dermatan sulfate biosynthesis 6 1.95e-01 -3.06e-01 4.69e-01
Cell-extracellular matrix interactions 15 4.07e-02 -3.05e-01 1.73e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 1.97e-01 -3.04e-01 4.71e-01
Formation of axial mesoderm 6 1.99e-01 3.03e-01 4.72e-01
Platelet Aggregation (Plug Formation) 29 4.78e-03 -3.03e-01 3.83e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 59 6.14e-05 -3.02e-01 1.82e-03
Josephin domain DUBs 10 9.91e-02 -3.01e-01 3.10e-01
Regulation of PTEN stability and activity 55 1.13e-04 -3.01e-01 2.60e-03
Translation initiation complex formation 58 7.43e-05 -3.01e-01 2.05e-03
Glyoxylate metabolism and glycine degradation 13 6.06e-02 -3.01e-01 2.28e-01
Ca2+ activated K+ channels 6 2.03e-01 -3.00e-01 4.79e-01
Signal transduction by L1 20 2.03e-02 -3.00e-01 1.08e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 5.95e-07 -2.99e-01 3.28e-05
SUMOylation of DNA damage response and repair proteins 77 5.52e-06 2.99e-01 2.31e-04
rRNA processing in the mitochondrion 24 1.11e-02 -2.99e-01 6.97e-02
MET receptor recycling 9 1.21e-01 -2.99e-01 3.49e-01
Downstream signaling of activated FGFR4 18 2.86e-02 2.98e-01 1.36e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 2.07e-01 -2.97e-01 4.85e-01
Respiratory electron transport 149 3.84e-10 -2.97e-01 8.21e-08
Ribosomal scanning and start codon recognition 58 9.24e-05 -2.97e-01 2.28e-03
Neurotransmitter clearance 5 2.51e-01 -2.97e-01 5.37e-01
Synthesis of UDP-N-acetyl-glucosamine 8 1.47e-01 2.96e-01 3.94e-01
Defective Intrinsic Pathway for Apoptosis 24 1.20e-02 -2.96e-01 7.35e-02
ISG15 antiviral mechanism 72 1.43e-05 2.96e-01 5.39e-04
Nuclear Envelope Breakdown 53 1.96e-04 2.96e-01 3.53e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 2.53e-01 2.95e-01 5.38e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 9.31e-04 -2.95e-01 1.15e-02
Cellular response to starvation 147 6.96e-10 -2.95e-01 1.34e-07
Signaling by FGFR1 in disease 32 4.08e-03 2.93e-01 3.38e-02
GABA synthesis, release, reuptake and degradation 11 9.32e-02 2.92e-01 2.98e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.14e-02 2.92e-01 7.04e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.14e-02 2.92e-01 7.04e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.14e-02 2.92e-01 7.04e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.14e-02 2.92e-01 7.04e-02
Loss of Function of SMAD2/3 in Cancer 7 1.81e-01 2.92e-01 4.51e-01
Homologous DNA Pairing and Strand Exchange 43 9.17e-04 2.92e-01 1.15e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 1.82e-01 -2.91e-01 4.51e-01
Metabolic disorders of biological oxidation enzymes 23 1.57e-02 -2.91e-01 9.08e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.27e-03 2.91e-01 1.41e-02
Diseases of DNA Double-Strand Break Repair 41 1.27e-03 2.91e-01 1.41e-02
Phospholipase C-mediated cascade; FGFR3 5 2.60e-01 2.91e-01 5.45e-01
Proteasome assembly 51 3.41e-04 -2.90e-01 5.26e-03
Spry regulation of FGF signaling 16 4.50e-02 -2.90e-01 1.85e-01
Platelet Adhesion to exposed collagen 15 5.22e-02 -2.89e-01 2.05e-01
Diseases of carbohydrate metabolism 29 6.98e-03 -2.89e-01 5.24e-02
Acetylcholine Neurotransmitter Release Cycle 10 1.14e-01 2.89e-01 3.39e-01
Phenylalanine metabolism 5 2.64e-01 -2.88e-01 5.49e-01
Nuclear events mediated by NFE2L2 82 6.45e-06 -2.88e-01 2.65e-04
Processive synthesis on the lagging strand 15 5.35e-02 2.88e-01 2.09e-01
Diseases of DNA repair 51 3.89e-04 2.87e-01 5.86e-03
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.37e-01 -2.87e-01 3.78e-01
Mitochondrial protein import 63 8.34e-05 -2.87e-01 2.23e-03
PINK1-PRKN Mediated Mitophagy 31 5.78e-03 -2.86e-01 4.46e-02
Gain-of-function MRAS complexes activate RAF signaling 8 1.61e-01 2.86e-01 4.20e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.61e-01 2.86e-01 4.20e-01
Signaling by MRAS-complex mutants 8 1.61e-01 2.86e-01 4.20e-01
Downstream signaling of activated FGFR3 17 4.11e-02 2.86e-01 1.73e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.41e-02 2.86e-01 2.36e-01
Complex IV assembly 45 9.11e-04 -2.86e-01 1.15e-02
Prevention of phagosomal-lysosomal fusion 9 1.39e-01 -2.85e-01 3.82e-01
Chondroitin sulfate biosynthesis 12 8.76e-02 -2.85e-01 2.90e-01
Formation of tubulin folding intermediates by CCT/TriC 21 2.43e-02 -2.84e-01 1.21e-01
SARS-CoV-2 modulates host translation machinery 49 5.98e-04 -2.83e-01 8.23e-03
Platelet sensitization by LDL 16 5.01e-02 -2.83e-01 1.98e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.97e-03 2.83e-01 1.93e-02
FGFR1 mutant receptor activation 25 1.44e-02 2.83e-01 8.51e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.77e-03 -2.82e-01 6.47e-02
Activation of Ca-permeable Kainate Receptor 9 1.44e-01 -2.81e-01 3.89e-01
Ionotropic activity of kainate receptors 9 1.44e-01 -2.81e-01 3.89e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 9.15e-02 -2.81e-01 2.94e-01
APC/C:Cdc20 mediated degradation of Securin 55 3.35e-04 -2.80e-01 5.25e-03
Biosynthesis of DHA-derived SPMs 14 7.06e-02 -2.79e-01 2.51e-01
RUNX2 regulates bone development 24 1.85e-02 -2.78e-01 1.02e-01
N-glycan trimming and elongation in the cis-Golgi 5 2.83e-01 2.77e-01 5.70e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.89e-03 -2.77e-01 1.89e-02
ROS and RNS production in phagocytes 30 8.64e-03 -2.77e-01 6.03e-02
RUNX1 regulates estrogen receptor mediated transcription 6 2.40e-01 2.77e-01 5.25e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 4.35e-04 -2.77e-01 6.44e-03
Regulation of expression of SLITs and ROBOs 148 6.14e-09 -2.77e-01 6.96e-07
Interleukin-20 family signaling 17 4.85e-02 2.76e-01 1.95e-01
Regulation of TP53 Activity through Acetylation 29 1.01e-02 2.76e-01 6.57e-02
Platelet degranulation 105 1.02e-06 -2.76e-01 5.47e-05
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 2.42e-01 -2.76e-01 5.28e-01
Stabilization of p53 43 1.78e-03 -2.75e-01 1.82e-02
Senescence-Associated Secretory Phenotype (SASP) 65 1.24e-04 -2.75e-01 2.75e-03
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.45e-01 2.74e-01 5.31e-01
HDR through Single Strand Annealing (SSA) 37 3.97e-03 2.74e-01 3.29e-02
FRS-mediated FGFR4 signaling 13 8.88e-02 2.73e-01 2.91e-01
Transport of RCbl within the body 8 1.82e-01 -2.72e-01 4.51e-01
Fatty acids 8 1.82e-01 -2.72e-01 4.51e-01
FGFR2c ligand binding and activation 5 2.93e-01 2.72e-01 5.78e-01
Downstream signaling of activated FGFR2 20 3.57e-02 2.71e-01 1.58e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.14e-02 -2.71e-01 1.12e-01
PTK6 Regulates Cell Cycle 6 2.53e-01 2.70e-01 5.38e-01
MECP2 regulates transcription factors 5 2.96e-01 2.70e-01 5.81e-01
CD209 (DC-SIGN) signaling 20 3.68e-02 2.70e-01 1.61e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.52e-03 2.69e-01 2.28e-02
Asymmetric localization of PCP proteins 49 1.11e-03 -2.69e-01 1.30e-02
Phosphate bond hydrolysis by NUDT proteins 7 2.18e-01 -2.69e-01 4.97e-01
FLT3 signaling by CBL mutants 7 2.19e-01 -2.68e-01 4.98e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.59e-02 2.68e-01 9.13e-02
Degradation of AXIN 42 2.67e-03 -2.68e-01 2.38e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 2.20e-01 2.68e-01 4.98e-01
Degradation of GLI2 by the proteasome 45 1.91e-03 -2.67e-01 1.89e-02
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.01e-01 2.67e-01 5.85e-01
GLI3 is processed to GLI3R by the proteasome 46 1.77e-03 -2.66e-01 1.82e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.11e-02 -2.66e-01 1.11e-01
IRAK1 recruits IKK complex 14 8.52e-02 -2.66e-01 2.85e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 8.52e-02 -2.66e-01 2.85e-01
CDC6 association with the ORC:origin complex 8 1.93e-01 2.66e-01 4.67e-01
Activated point mutants of FGFR2 7 2.26e-01 2.65e-01 5.08e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 8.69e-02 -2.64e-01 2.89e-01
Mitochondrial RNA degradation 25 2.23e-02 -2.64e-01 1.14e-01
Mitophagy 38 4.87e-03 -2.64e-01 3.89e-02
Antigen processing-Cross presentation 89 1.72e-05 -2.64e-01 5.82e-04
SIRT1 negatively regulates rRNA expression 22 3.30e-02 -2.63e-01 1.51e-01
ERKs are inactivated 13 1.01e-01 -2.62e-01 3.15e-01
Removal of the Flap Intermediate 14 8.93e-02 2.62e-01 2.92e-01
GP1b-IX-V activation signalling 11 1.32e-01 -2.62e-01 3.68e-01
Response to elevated platelet cytosolic Ca2+ 109 2.30e-06 -2.62e-01 1.14e-04
PKMTs methylate histone lysines 43 2.97e-03 2.62e-01 2.60e-02
ERBB2 Activates PTK6 Signaling 8 2.00e-01 -2.61e-01 4.76e-01
Glycerophospholipid catabolism 7 2.31e-01 -2.61e-01 5.14e-01
Sulfur amino acid metabolism 22 3.38e-02 -2.61e-01 1.53e-01
Molecules associated with elastic fibres 26 2.12e-02 -2.61e-01 1.11e-01
Xenobiotics 12 1.17e-01 2.61e-01 3.42e-01
Dectin-2 family 19 4.95e-02 -2.60e-01 1.97e-01
Smooth Muscle Contraction 34 8.72e-03 -2.60e-01 6.04e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 7.19e-02 2.60e-01 2.54e-01
NFE2L2 regulates pentose phosphate pathway genes 8 2.04e-01 -2.60e-01 4.79e-01
Mismatch Repair 15 8.18e-02 2.60e-01 2.79e-01
Regulation of RUNX2 expression and activity 54 1.03e-03 -2.58e-01 1.23e-02
Cobalamin (Cbl) metabolism 7 2.37e-01 2.58e-01 5.23e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 3.47e-03 2.58e-01 2.96e-02
Acyl chain remodelling of PI 10 1.59e-01 -2.57e-01 4.19e-01
NOTCH2 intracellular domain regulates transcription 11 1.40e-01 2.57e-01 3.84e-01
tRNA processing in the mitochondrion 24 2.94e-02 -2.57e-01 1.38e-01
Glycogen metabolism 22 3.72e-02 -2.57e-01 1.62e-01
VEGF binds to VEGFR leading to receptor dimerization 5 3.21e-01 -2.56e-01 6.10e-01
VEGF ligand-receptor interactions 5 3.21e-01 -2.56e-01 6.10e-01
Packaging Of Telomere Ends 18 5.97e-02 -2.56e-01 2.26e-01
SUMOylation 167 1.18e-08 2.56e-01 1.08e-06
Selenoamino acid metabolism 114 2.51e-06 -2.55e-01 1.21e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.87e-04 2.55e-01 3.47e-03
NFE2L2 regulating ER-stress associated genes 5 3.25e-01 2.54e-01 6.16e-01
FRS-mediated FGFR3 signaling 12 1.28e-01 2.54e-01 3.63e-01
Defective GALNT12 causes CRCS1 9 1.89e-01 -2.53e-01 4.64e-01
RA biosynthesis pathway 13 1.15e-01 -2.52e-01 3.41e-01
Transport of vitamins, nucleosides, and related molecules 31 1.50e-02 -2.52e-01 8.75e-02
Creatine metabolism 6 2.85e-01 2.52e-01 5.70e-01
Aerobic respiration and respiratory electron transport 245 1.07e-11 -2.52e-01 2.95e-09
RSV-host interactions 78 1.19e-04 2.52e-01 2.71e-03
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 1.91e-01 -2.52e-01 4.64e-01
Negative feedback regulation of MAPK pathway 6 2.85e-01 -2.52e-01 5.70e-01
Phospholipase C-mediated cascade; FGFR2 8 2.18e-01 2.52e-01 4.97e-01
Beta-oxidation of pristanoyl-CoA 9 1.91e-01 -2.52e-01 4.64e-01
Gluconeogenesis 19 5.76e-02 -2.52e-01 2.19e-01
Sema4D in semaphorin signaling 22 4.21e-02 -2.50e-01 1.77e-01
mTORC1-mediated signalling 24 3.38e-02 -2.50e-01 1.53e-01
Frs2-mediated activation 11 1.51e-01 -2.50e-01 4.04e-01
Arachidonate production from DAG 5 3.33e-01 -2.50e-01 6.23e-01
SUMOylation of RNA binding proteins 47 3.03e-03 2.50e-01 2.64e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.06e-01 -2.50e-01 3.23e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.06e-01 -2.50e-01 3.23e-01
Formation of WDR5-containing histone-modifying complexes 42 5.18e-03 2.49e-01 4.06e-02
ER-Phagosome pathway 75 1.93e-04 -2.49e-01 3.51e-03
Carnitine shuttle 12 1.37e-01 2.48e-01 3.78e-01
Telomere C-strand (Lagging Strand) Synthesis 34 1.24e-02 2.48e-01 7.49e-02
Abacavir ADME 5 3.39e-01 2.47e-01 6.29e-01
Cellular response to hypoxia 59 1.03e-03 -2.47e-01 1.23e-02
SUMO E3 ligases SUMOylate target proteins 161 6.78e-08 2.46e-01 4.66e-06
SUMOylation of chromatin organization proteins 57 1.34e-03 2.46e-01 1.46e-02
Carboxyterminal post-translational modifications of tubulin 34 1.33e-02 -2.45e-01 7.89e-02
Intrinsic Pathway of Fibrin Clot Formation 15 1.00e-01 -2.45e-01 3.13e-01
Downregulation of ERBB4 signaling 8 2.30e-01 -2.45e-01 5.14e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 1.60e-01 -2.45e-01 4.19e-01
Insulin receptor recycling 24 3.79e-02 -2.45e-01 1.64e-01
Transcriptional regulation of granulopoiesis 44 5.02e-03 -2.44e-01 4.00e-02
Cytosolic sulfonation of small molecules 18 7.32e-02 -2.44e-01 2.58e-01
Evasion by RSV of host interferon responses 20 6.09e-02 2.42e-01 2.29e-01
Early Phase of HIV Life Cycle 14 1.17e-01 2.42e-01 3.42e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 3.51e-01 2.41e-01 6.39e-01
Regulation of RAS by GAPs 55 2.01e-03 -2.41e-01 1.96e-02
Degradation of GLI1 by the proteasome 46 4.78e-03 -2.40e-01 3.83e-02
FRS-mediated FGFR2 signaling 15 1.07e-01 2.40e-01 3.26e-01
p130Cas linkage to MAPK signaling for integrins 11 1.67e-01 -2.40e-01 4.32e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 3.83e-02 2.39e-01 1.65e-01
Signaling by TGFBR3 39 9.70e-03 2.39e-01 6.44e-02
NRIF signals cell death from the nucleus 15 1.09e-01 -2.39e-01 3.28e-01
Formation of the ureteric bud 5 3.58e-01 -2.37e-01 6.44e-01
Cleavage of the damaged purine 22 5.38e-02 -2.37e-01 2.09e-01
Depurination 22 5.38e-02 -2.37e-01 2.09e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 5.38e-02 -2.37e-01 2.09e-01
Integrin signaling 22 5.42e-02 -2.37e-01 2.10e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 3.17e-01 -2.36e-01 6.05e-01
Regulation of localization of FOXO transcription factors 12 1.57e-01 -2.36e-01 4.15e-01
RSK activation 7 2.80e-01 -2.36e-01 5.68e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.76e-01 -2.35e-01 4.43e-01
Circadian Clock 67 8.59e-04 2.35e-01 1.10e-02
Constitutive Signaling by EGFRvIII 14 1.27e-01 2.35e-01 3.62e-01
Signaling by EGFRvIII in Cancer 14 1.27e-01 2.35e-01 3.62e-01
Complex III assembly 23 5.13e-02 -2.35e-01 2.02e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 1.52e-03 -2.35e-01 1.63e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 2.50e-01 2.35e-01 5.37e-01
Signaling by PDGFRA extracellular domain mutants 12 1.59e-01 2.35e-01 4.19e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.59e-01 2.35e-01 4.19e-01
Keratinization 38 1.25e-02 -2.34e-01 7.52e-02
NIK–>noncanonical NF-kB signaling 46 6.04e-03 -2.34e-01 4.60e-02
SCF(Skp2)-mediated degradation of p27/p21 50 4.24e-03 -2.34e-01 3.46e-02
SHC-related events triggered by IGF1R 7 2.85e-01 2.33e-01 5.70e-01
TGFBR3 regulates TGF-beta signaling 8 2.54e-01 2.33e-01 5.40e-01
Inwardly rectifying K+ channels 23 5.32e-02 -2.33e-01 2.08e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 1.82e-01 -2.32e-01 4.51e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 2.04e-01 -2.32e-01 4.79e-01
ABC-family proteins mediated transport 81 3.13e-04 -2.32e-01 5.03e-03
Signaling by ROBO receptors 188 4.61e-08 -2.31e-01 3.29e-06
TNFs bind their physiological receptors 25 4.55e-02 -2.31e-01 1.85e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 3.71e-01 -2.31e-01 6.58e-01
Signalling to ERKs 32 2.40e-02 -2.31e-01 1.21e-01
Elastic fibre formation 33 2.20e-02 -2.30e-01 1.14e-01
Activation of the pre-replicative complex 32 2.43e-02 2.30e-01 1.21e-01
Miro GTPase Cycle 8 2.60e-01 -2.30e-01 5.45e-01
CREB phosphorylation 7 2.93e-01 2.30e-01 5.78e-01
Regulation of TP53 Activity through Association with Co-factors 13 1.53e-01 2.29e-01 4.07e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.68e-03 -2.29e-01 1.76e-02
Inactivation of CDC42 and RAC1 7 2.94e-01 -2.29e-01 5.81e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 2.24e-03 -2.28e-01 2.10e-02
Beta-oxidation of very long chain fatty acids 11 1.90e-01 -2.28e-01 4.64e-01
SHC-mediated cascade:FGFR4 11 1.91e-01 2.28e-01 4.64e-01
PCP/CE pathway 75 6.56e-04 -2.28e-01 8.77e-03
Defective C1GALT1C1 causes TNPS 10 2.14e-01 -2.27e-01 4.94e-01
Activation of ATR in response to replication stress 37 1.70e-02 2.27e-01 9.59e-02
CDK-mediated phosphorylation and removal of Cdc6 60 2.41e-03 -2.26e-01 2.20e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 2.26e-03 -2.26e-01 2.11e-02
Thyroxine biosynthesis 5 3.82e-01 -2.26e-01 6.65e-01
PI3K/AKT activation 8 2.70e-01 -2.25e-01 5.54e-01
Regulation of signaling by NODAL 6 3.39e-01 -2.25e-01 6.29e-01
Citric acid cycle (TCA cycle) 34 2.33e-02 -2.25e-01 1.18e-01
Cell recruitment (pro-inflammatory response) 25 5.19e-02 -2.25e-01 2.04e-01
Purinergic signaling in leishmaniasis infection 25 5.19e-02 -2.25e-01 2.04e-01
Regulation of IFNA/IFNB signaling 12 1.81e-01 2.23e-01 4.51e-01
RHOBTB2 GTPase cycle 23 6.45e-02 2.23e-01 2.37e-01
Glycosphingolipid metabolism 46 9.02e-03 -2.23e-01 6.19e-02
Glycogen synthesis 11 2.01e-01 -2.22e-01 4.78e-01
Transcriptional regulation by RUNX2 89 3.05e-04 -2.21e-01 4.99e-03
Signaling by Leptin 10 2.26e-01 -2.21e-01 5.08e-01
Role of second messengers in netrin-1 signaling 6 3.48e-01 -2.21e-01 6.36e-01
ABC transporter disorders 60 3.11e-03 -2.21e-01 2.69e-02
Lagging Strand Synthesis 20 8.77e-02 2.21e-01 2.90e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.53e-01 2.20e-01 4.08e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 2.34e-03 -2.20e-01 2.16e-02
Formation of the cornified envelope 37 2.07e-02 -2.20e-01 1.09e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 3.14e-01 2.20e-01 6.03e-01
Activated NTRK2 signals through FRS2 and FRS3 8 2.83e-01 2.19e-01 5.70e-01
Signaling by ALK 24 6.34e-02 2.19e-01 2.35e-01
Processing and activation of SUMO 10 2.31e-01 2.19e-01 5.14e-01
Respiratory Syncytial Virus Infection Pathway 99 1.69e-04 2.19e-01 3.34e-03
Signaling by NODAL 15 1.44e-01 -2.18e-01 3.89e-01
Inflammasomes 21 8.51e-02 -2.17e-01 2.85e-01
Metabolism of amino acids and derivatives 305 7.80e-11 -2.16e-01 1.88e-08
Somitogenesis 41 1.65e-02 -2.16e-01 9.36e-02
Negative regulation of FGFR1 signaling 25 6.12e-02 -2.16e-01 2.29e-01
Viral Messenger RNA Synthesis 44 1.31e-02 2.16e-01 7.82e-02
Chondroitin sulfate/dermatan sulfate metabolism 39 1.95e-02 -2.16e-01 1.06e-01
ERBB2 Regulates Cell Motility 10 2.38e-01 -2.16e-01 5.24e-01
TYSND1 cleaves peroxisomal proteins 7 3.23e-01 -2.16e-01 6.14e-01
Regulation of PTEN localization 9 2.63e-01 -2.15e-01 5.48e-01
MAP2K and MAPK activation 36 2.56e-02 -2.15e-01 1.26e-01
Purine catabolism 16 1.37e-01 -2.14e-01 3.80e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.64e-01 -2.14e-01 6.49e-01
Ephrin signaling 18 1.16e-01 -2.14e-01 3.42e-01
KEAP1-NFE2L2 pathway 107 1.31e-04 -2.14e-01 2.79e-03
Signaling by NOTCH4 68 2.27e-03 -2.14e-01 2.11e-02
p38MAPK events 13 1.82e-01 -2.14e-01 4.51e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 4.08e-01 -2.14e-01 6.78e-01
Pyrimidine catabolism 9 2.67e-01 -2.14e-01 5.52e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 4.08e-01 2.14e-01 6.78e-01
Cellular response to mitochondrial stress 9 2.67e-01 -2.14e-01 5.52e-01
Activation of RAC1 11 2.20e-01 -2.14e-01 4.98e-01
FLT3 signaling through SRC family kinases 6 3.65e-01 -2.13e-01 6.51e-01
NPAS4 regulates expression of target genes 16 1.40e-01 -2.13e-01 3.83e-01
Polo-like kinase mediated events 16 1.40e-01 2.13e-01 3.83e-01
G1/S DNA Damage Checkpoints 54 6.72e-03 -2.13e-01 5.06e-02
p53-Dependent G1 DNA Damage Response 52 8.11e-03 -2.12e-01 5.83e-02
p53-Dependent G1/S DNA damage checkpoint 52 8.11e-03 -2.12e-01 5.83e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 2.70e-01 -2.12e-01 5.54e-01
Antiviral mechanism by IFN-stimulated genes 140 1.52e-05 2.12e-01 5.51e-04
Interferon Signaling 240 1.81e-08 2.11e-01 1.43e-06
Diseases associated with N-glycosylation of proteins 20 1.03e-01 -2.11e-01 3.19e-01
Regulation of gene expression in beta cells 8 3.02e-01 2.11e-01 5.87e-01
Regulation of HSF1-mediated heat shock response 79 1.23e-03 2.10e-01 1.40e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 4.16e-01 2.10e-01 6.85e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 4.16e-01 2.10e-01 6.85e-01
Regulation of BACH1 activity 11 2.28e-01 -2.10e-01 5.11e-01
Laminin interactions 26 6.41e-02 -2.10e-01 2.36e-01
Prolonged ERK activation events 13 1.90e-01 -2.10e-01 4.64e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 2.77e-01 -2.09e-01 5.65e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.51e-01 -2.09e-01 5.37e-01
BBSome-mediated cargo-targeting to cilium 23 8.23e-02 2.09e-01 2.80e-01
TNFR1-mediated ceramide production 6 3.76e-01 2.09e-01 6.60e-01
Translocation of ZAP-70 to Immunological synapse 24 7.69e-02 2.09e-01 2.67e-01
Metabolism of non-coding RNA 53 8.62e-03 2.09e-01 6.03e-02
snRNP Assembly 53 8.62e-03 2.09e-01 6.03e-02
Inhibition of DNA recombination at telomere 33 3.82e-02 -2.08e-01 1.65e-01
Selective autophagy 77 1.59e-03 -2.08e-01 1.69e-02
Physiological factors 9 2.83e-01 -2.07e-01 5.70e-01
Interleukin-35 Signalling 12 2.15e-01 2.07e-01 4.95e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.15e-01 2.06e-01 4.95e-01
Glycogen storage diseases 13 1.98e-01 -2.06e-01 4.71e-01
FGFR2 alternative splicing 25 7.46e-02 -2.06e-01 2.62e-01
Transport of Mature Transcript to Cytoplasm 81 1.39e-03 2.05e-01 1.50e-02
Mitochondrial protein degradation 96 5.14e-04 -2.05e-01 7.33e-03
Deadenylation of mRNA 22 9.60e-02 2.05e-01 3.03e-01
Condensation of Prometaphase Chromosomes 11 2.40e-01 2.05e-01 5.25e-01
Downregulation of ERBB2:ERBB3 signaling 12 2.20e-01 -2.05e-01 4.98e-01
Transcriptional activation of mitochondrial biogenesis 52 1.08e-02 2.04e-01 6.84e-02
Infection with Mycobacterium tuberculosis 26 7.20e-02 -2.04e-01 2.54e-01
Molybdenum cofactor biosynthesis 6 3.88e-01 2.04e-01 6.66e-01
RUNX2 regulates genes involved in cell migration 6 3.89e-01 -2.03e-01 6.66e-01
Interconversion of nucleotide di- and triphosphates 27 6.78e-02 -2.03e-01 2.43e-01
Interleukin-6 signaling 11 2.44e-01 2.03e-01 5.31e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 7.90e-02 2.03e-01 2.74e-01
Assembly of the ORC complex at the origin of replication 23 9.29e-02 -2.02e-01 2.98e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 1.55e-02 -2.02e-01 8.99e-02
Signaling by RNF43 mutants 7 3.55e-01 2.02e-01 6.44e-01
GDP-fucose biosynthesis 6 3.94e-01 -2.01e-01 6.69e-01
Gap junction assembly 17 1.52e-01 -2.01e-01 4.07e-01
Acyl chain remodelling of PE 20 1.21e-01 -2.00e-01 3.49e-01
SHC-mediated cascade:FGFR3 10 2.72e-01 2.00e-01 5.57e-01
Pre-NOTCH Processing in Golgi 18 1.41e-01 2.00e-01 3.84e-01
Signaling by high-kinase activity BRAF mutants 33 4.65e-02 -2.00e-01 1.88e-01
Cellular response to chemical stress 179 3.84e-06 -2.00e-01 1.76e-04
PD-1 signaling 28 6.68e-02 2.00e-01 2.40e-01
RNA Polymerase I Promoter Escape 45 2.04e-02 -2.00e-01 1.08e-01
Sphingolipid metabolism 92 9.36e-04 -2.00e-01 1.15e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.22e-01 2.00e-01 3.51e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.40e-01 1.99e-01 7.07e-01
Cellular response to heat stress 94 8.43e-04 1.99e-01 1.09e-02
Mitochondrial Fatty Acid Beta-Oxidation 36 3.87e-02 -1.99e-01 1.66e-01
Neurotoxicity of clostridium toxins 8 3.31e-01 1.98e-01 6.21e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.72e-01 -1.97e-01 4.36e-01
SHC-mediated cascade:FGFR2 13 2.18e-01 1.97e-01 4.97e-01
Defects in cobalamin (B12) metabolism 13 2.18e-01 1.97e-01 4.97e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 5 4.45e-01 -1.97e-01 7.10e-01
Methionine salvage pathway 6 4.03e-01 -1.97e-01 6.75e-01
TNFR2 non-canonical NF-kB pathway 84 1.83e-03 -1.97e-01 1.86e-02
Metabolism of folate and pterines 16 1.73e-01 -1.97e-01 4.40e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 2.39e-01 -1.96e-01 5.25e-01
activated TAK1 mediates p38 MAPK activation 23 1.03e-01 -1.96e-01 3.20e-01
APOBEC3G mediated resistance to HIV-1 infection 5 4.48e-01 1.96e-01 7.14e-01
Sema4D induced cell migration and growth-cone collapse 19 1.41e-01 -1.95e-01 3.84e-01
Sema4D mediated inhibition of cell attachment and migration 7 3.71e-01 -1.95e-01 6.58e-01
Attenuation phase 23 1.06e-01 1.95e-01 3.23e-01
HSF1-dependent transactivation 30 6.54e-02 1.94e-01 2.38e-01
Coenzyme A biosynthesis 7 3.74e-01 1.94e-01 6.60e-01
Translation 292 1.17e-08 -1.94e-01 1.08e-06
Activation of NF-kappaB in B cells 54 1.37e-02 -1.94e-01 8.10e-02
SARS-CoV-2 modulates autophagy 11 2.66e-01 1.94e-01 5.51e-01
Mitochondrial translation elongation 90 1.49e-03 -1.94e-01 1.61e-02
Metabolism of porphyrins 22 1.17e-01 -1.93e-01 3.42e-01
PI5P Regulates TP53 Acetylation 8 3.45e-01 1.93e-01 6.35e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 5.36e-04 1.93e-01 7.49e-03
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 3.77e-01 -1.93e-01 6.61e-01
Depolymerization of the Nuclear Lamina 15 1.97e-01 1.93e-01 4.70e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.10e-01 -1.92e-01 3.31e-01
Activation of C3 and C5 7 3.78e-01 -1.92e-01 6.61e-01
tRNA processing in the nucleus 59 1.06e-02 1.92e-01 6.75e-02
Small interfering RNA (siRNA) biogenesis 9 3.18e-01 1.92e-01 6.07e-01
RHOT2 GTPase cycle 7 3.80e-01 -1.92e-01 6.63e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 4.45e-04 -1.91e-01 6.45e-03
Nonsense-Mediated Decay (NMD) 113 4.45e-04 -1.91e-01 6.45e-03
CRMPs in Sema3A signaling 14 2.16e-01 -1.91e-01 4.95e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 5.43e-02 1.91e-01 2.10e-01
Assembly of the pre-replicative complex 87 2.13e-03 -1.91e-01 2.04e-02
Basigin interactions 21 1.32e-01 -1.90e-01 3.68e-01
Formation of annular gap junctions 10 2.99e-01 -1.90e-01 5.83e-01
Phosphorylation of CD3 and TCR zeta chains 27 8.81e-02 1.90e-01 2.90e-01
Regulation of RUNX1 Expression and Activity 18 1.64e-01 1.89e-01 4.26e-01
Netrin mediated repulsion signals 5 4.67e-01 -1.88e-01 7.21e-01
Amino acids regulate mTORC1 48 2.44e-02 -1.88e-01 1.21e-01
Metabolism of cofactors 25 1.04e-01 -1.88e-01 3.22e-01
Extension of Telomeres 51 2.05e-02 1.88e-01 1.09e-01
Myoclonic epilepsy of Lafora 8 3.59e-01 -1.87e-01 6.45e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.21e-01 -1.87e-01 3.49e-01
IkBA variant leads to EDA-ID 7 3.92e-01 1.87e-01 6.68e-01
SOS-mediated signalling 7 3.98e-01 -1.84e-01 6.74e-01
Protein localization 157 6.82e-05 -1.84e-01 1.97e-03
UCH proteinases 73 6.52e-03 -1.84e-01 4.93e-02
Activation of BH3-only proteins 30 8.09e-02 -1.84e-01 2.79e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 3.14e-01 1.84e-01 6.03e-01
Semaphorin interactions 57 1.64e-02 -1.84e-01 9.32e-02
Ubiquinol biosynthesis 13 2.51e-01 -1.84e-01 5.37e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 3.68e-01 1.84e-01 6.53e-01
Chaperone Mediated Autophagy 20 1.56e-01 -1.83e-01 4.13e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.93e-01 -1.83e-01 5.78e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 8.25e-02 1.83e-01 2.80e-01
Nephron development 5 4.79e-01 1.83e-01 7.29e-01
Gap junction trafficking and regulation 30 8.36e-02 -1.83e-01 2.83e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 4.04e-01 -1.82e-01 6.75e-01
Interleukin-1 signaling 99 1.75e-03 -1.82e-01 1.82e-02
Incretin synthesis, secretion, and inactivation 14 2.39e-01 -1.82e-01 5.25e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 2.39e-01 -1.82e-01 5.25e-01
ECM proteoglycans 47 3.14e-02 -1.81e-01 1.45e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 4.42e-01 1.81e-01 7.09e-01
TGFBR1 KD Mutants in Cancer 6 4.42e-01 1.81e-01 7.09e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 1.17e-01 1.81e-01 3.42e-01
Uptake and function of diphtheria toxin 6 4.43e-01 -1.81e-01 7.09e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 2.41e-02 -1.81e-01 1.21e-01
Recycling pathway of L1 40 4.79e-02 -1.81e-01 1.93e-01
Degradation of beta-catenin by the destruction complex 72 8.32e-03 -1.80e-01 5.92e-02
Platelet activation, signaling and aggregation 221 4.33e-06 -1.79e-01 1.94e-04
Integration of provirus 9 3.53e-01 1.79e-01 6.42e-01
Surfactant metabolism 20 1.67e-01 -1.79e-01 4.31e-01
FLT3 signaling in disease 27 1.08e-01 1.78e-01 3.28e-01
Condensation of Prophase Chromosomes 27 1.09e-01 -1.78e-01 3.28e-01
Activation of AMPK downstream of NMDARs 20 1.69e-01 -1.77e-01 4.35e-01
Signaling by ERBB2 ECD mutants 15 2.34e-01 1.77e-01 5.18e-01
Deactivation of the beta-catenin transactivating complex 36 6.54e-02 1.77e-01 2.38e-01
Cyclin E associated events during G1/S transition 73 8.77e-03 -1.77e-01 6.06e-02
G0 and Early G1 27 1.13e-01 1.76e-01 3.38e-01
Signaling by KIT in disease 20 1.74e-01 1.75e-01 4.41e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 1.74e-01 1.75e-01 4.41e-01
Organic cation transport 8 3.90e-01 -1.75e-01 6.66e-01
Organic cation/anion/zwitterion transport 8 3.90e-01 -1.75e-01 6.66e-01
TP53 Regulates Metabolic Genes 78 7.43e-03 -1.75e-01 5.45e-02
Metabolism of steroid hormones 21 1.64e-01 -1.75e-01 4.26e-01
Interleukin-1 family signaling 127 6.59e-04 -1.75e-01 8.77e-03
Sodium/Calcium exchangers 9 3.64e-01 -1.75e-01 6.49e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 1.76e-01 -1.75e-01 4.43e-01
Azathioprine ADME 20 1.76e-01 -1.75e-01 4.43e-01
Norepinephrine Neurotransmitter Release Cycle 12 2.95e-01 1.75e-01 5.81e-01
AURKA Activation by TPX2 72 1.05e-02 1.74e-01 6.70e-02
Cholesterol biosynthesis 26 1.24e-01 -1.74e-01 3.54e-01
Maturation of nucleoprotein 9683610 11 3.17e-01 1.74e-01 6.05e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 3.40e-01 -1.74e-01 6.29e-01
MyD88 deficiency (TLR2/4) 14 2.60e-01 -1.74e-01 5.45e-01
Serotonin Neurotransmitter Release Cycle 13 2.77e-01 1.74e-01 5.65e-01
Regulation of lipid metabolism by PPARalpha 107 1.91e-03 1.74e-01 1.89e-02
Gap junction trafficking 28 1.12e-01 -1.74e-01 3.35e-01
Signaling by Erythropoietin 24 1.41e-01 1.73e-01 3.85e-01
Mitochondrial translation initiation 90 4.60e-03 -1.73e-01 3.73e-02
Resolution of D-Loop Structures 35 7.69e-02 1.73e-01 2.67e-01
Transcriptional regulation by RUNX3 80 7.56e-03 -1.73e-01 5.51e-02
Regulation of gene expression by Hypoxia-inducible Factor 8 3.99e-01 1.72e-01 6.74e-01
Transferrin endocytosis and recycling 26 1.29e-01 -1.72e-01 3.64e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 1.83e-01 1.72e-01 4.52e-01
Trafficking of AMPA receptors 20 1.83e-01 1.72e-01 4.52e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 9.65e-03 -1.72e-01 6.43e-02
Transcriptional Regulation by MECP2 49 3.79e-02 1.71e-01 1.64e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.25e-01 -1.71e-01 6.17e-01
TRAIL signaling 8 4.02e-01 1.71e-01 6.75e-01
Interferon gamma signaling 90 5.05e-03 1.71e-01 4.00e-02
Interleukin-2 signaling 11 3.26e-01 1.71e-01 6.17e-01
TRIF-mediated programmed cell death 9 3.76e-01 1.70e-01 6.60e-01
Mitochondrial translation termination 90 5.30e-03 -1.70e-01 4.10e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.16e-02 -1.70e-01 1.75e-01
Cyclin A:Cdk2-associated events at S phase entry 75 1.12e-02 -1.69e-01 6.98e-02
Interaction between L1 and Ankyrins 27 1.28e-01 1.69e-01 3.62e-01
Mitochondrial translation 96 4.19e-03 -1.69e-01 3.44e-02
PKA activation 15 2.59e-01 -1.68e-01 5.44e-01
Iron uptake and transport 52 3.56e-02 -1.68e-01 1.58e-01
CLEC7A (Dectin-1) induces NFAT activation 11 3.35e-01 1.68e-01 6.25e-01
Oncogene Induced Senescence 33 9.51e-02 -1.68e-01 3.01e-01
PPARA activates gene expression 105 2.96e-03 1.68e-01 2.60e-02
SLC transporter disorders 76 1.18e-02 1.67e-01 7.19e-02
Chemokine receptors bind chemokines 41 6.41e-02 -1.67e-01 2.36e-01
Formation of apoptosome 11 3.37e-01 -1.67e-01 6.27e-01
Regulation of the apoptosome activity 11 3.37e-01 -1.67e-01 6.27e-01
FGFRL1 modulation of FGFR1 signaling 7 4.45e-01 -1.67e-01 7.10e-01
Ca2+ pathway 58 2.83e-02 1.66e-01 1.35e-01
RHOQ GTPase cycle 54 3.50e-02 -1.66e-01 1.56e-01
DNA replication initiation 8 4.17e-01 1.66e-01 6.85e-01
Lysosome Vesicle Biogenesis 32 1.06e-01 -1.65e-01 3.23e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 3.66e-01 1.65e-01 6.51e-01
2-LTR circle formation 7 4.51e-01 1.65e-01 7.14e-01
Interleukin-15 signaling 14 2.88e-01 1.64e-01 5.73e-01
MAPK6/MAPK4 signaling 69 1.86e-02 -1.64e-01 1.02e-01
Fatty acid metabolism 157 4.03e-04 -1.64e-01 6.03e-03
Orc1 removal from chromatin 58 3.12e-02 -1.64e-01 1.45e-01
Ribavirin ADME 11 3.49e-01 -1.63e-01 6.36e-01
Phase II - Conjugation of compounds 70 1.84e-02 -1.63e-01 1.02e-01
Activation of G protein gated Potassium channels 19 2.21e-01 -1.62e-01 5.00e-01
G protein gated Potassium channels 19 2.21e-01 -1.62e-01 5.00e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 2.21e-01 -1.62e-01 5.00e-01
Malate-aspartate shuttle 8 4.28e-01 -1.62e-01 6.95e-01
Attachment and Entry 9694614 15 2.79e-01 1.61e-01 5.68e-01
Netrin-1 signaling 35 9.86e-02 -1.61e-01 3.10e-01
PKA activation in glucagon signalling 14 2.96e-01 -1.61e-01 5.81e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.82e-01 -1.61e-01 4.51e-01
Mitochondrial calcium ion transport 22 1.92e-01 -1.61e-01 4.65e-01
Synthesis of Ketone Bodies 6 4.96e-01 -1.60e-01 7.40e-01
Activation of SMO 14 2.99e-01 1.60e-01 5.83e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 4.98e-01 -1.60e-01 7.42e-01
Ethanol oxidation 7 4.65e-01 -1.59e-01 7.20e-01
Repression of WNT target genes 14 3.02e-01 1.59e-01 5.87e-01
Peroxisomal protein import 58 3.59e-02 -1.59e-01 1.59e-01
Regulation of TP53 Activity through Phosphorylation 88 9.88e-03 1.59e-01 6.52e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 1.87e-01 -1.59e-01 4.59e-01
Elevation of cytosolic Ca2+ levels 13 3.21e-01 -1.59e-01 6.10e-01
DNA Damage Reversal 8 4.36e-01 1.59e-01 7.04e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 76 1.71e-02 -1.58e-01 9.63e-02
Formation of paraxial mesoderm 52 4.97e-02 -1.57e-01 1.98e-01
IL-6-type cytokine receptor ligand interactions 13 3.26e-01 -1.57e-01 6.17e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 2.92e-01 1.57e-01 5.78e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 9.63e-03 1.57e-01 6.43e-02
Amplification of signal from the kinetochores 91 9.63e-03 1.57e-01 6.43e-02
Loss of Nlp from mitotic centrosomes 69 2.42e-02 1.57e-01 1.21e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 2.42e-02 1.57e-01 1.21e-01
Signaling by RAF1 mutants 37 9.92e-02 -1.57e-01 3.10e-01
Non-integrin membrane-ECM interactions 49 5.79e-02 -1.57e-01 2.20e-01
Negative regulation of MET activity 18 2.50e-01 -1.57e-01 5.37e-01
Regulation of beta-cell development 22 2.04e-01 1.57e-01 4.79e-01
Resolution of Abasic Sites (AP sites) 38 9.50e-02 1.57e-01 3.01e-01
COPI-independent Golgi-to-ER retrograde traffic 45 6.93e-02 -1.56e-01 2.47e-01
Innate Immune System 970 1.60e-16 -1.56e-01 1.03e-13
DCC mediated attractive signaling 13 3.29e-01 -1.56e-01 6.19e-01
Formation of the Early Elongation Complex 33 1.21e-01 -1.56e-01 3.49e-01
Formation of the HIV-1 Early Elongation Complex 33 1.21e-01 -1.56e-01 3.49e-01
Blood group systems biosynthesis 17 2.66e-01 -1.56e-01 5.51e-01
Chromatin modifying enzymes 214 9.22e-05 1.55e-01 2.28e-03
Chromatin organization 214 9.22e-05 1.55e-01 2.28e-03
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 3.62e-02 1.55e-01 1.59e-01
Cation-coupled Chloride cotransporters 6 5.11e-01 1.55e-01 7.54e-01
DAP12 signaling 28 1.57e-01 1.55e-01 4.15e-01
Glutathione synthesis and recycling 10 3.97e-01 -1.55e-01 6.72e-01
Processing of Capped Intron-Containing Pre-mRNA 279 8.80e-06 1.55e-01 3.53e-04
MET activates RAP1 and RAC1 10 3.97e-01 -1.55e-01 6.72e-01
Alpha-oxidation of phytanate 6 5.13e-01 -1.54e-01 7.56e-01
SUMOylation of immune response proteins 12 3.57e-01 1.54e-01 6.44e-01
Noncanonical activation of NOTCH3 8 4.52e-01 -1.54e-01 7.14e-01
LGI-ADAM interactions 9 4.26e-01 1.53e-01 6.94e-01
Regulation of APC/C activators between G1/S and early anaphase 68 2.89e-02 -1.53e-01 1.37e-01
Base-Excision Repair, AP Site Formation 29 1.54e-01 -1.53e-01 4.09e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 9.02e-02 -1.53e-01 2.93e-01
Signaling by RAS mutants 41 9.02e-02 -1.53e-01 2.93e-01
Signaling by moderate kinase activity BRAF mutants 41 9.02e-02 -1.53e-01 2.93e-01
Signaling downstream of RAS mutants 41 9.02e-02 -1.53e-01 2.93e-01
STAT5 Activation 7 4.84e-01 1.53e-01 7.34e-01
Defective GALNT3 causes HFTC 9 4.28e-01 -1.53e-01 6.95e-01
G alpha (z) signalling events 36 1.13e-01 -1.52e-01 3.38e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 1.71e-01 -1.52e-01 4.36e-01
PCNA-Dependent Long Patch Base Excision Repair 21 2.28e-01 1.52e-01 5.11e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 3.63e-01 1.52e-01 6.49e-01
NGF-stimulated transcription 32 1.38e-01 -1.52e-01 3.80e-01
Alpha-protein kinase 1 signaling pathway 11 3.84e-01 -1.51e-01 6.66e-01
Interleukin-23 signaling 7 4.88e-01 1.51e-01 7.36e-01
Anchoring of the basal body to the plasma membrane 97 1.01e-02 1.51e-01 6.57e-02
RAF/MAP kinase cascade 225 9.46e-05 -1.51e-01 2.31e-03
Negative regulation of MAPK pathway 42 9.04e-02 -1.51e-01 2.93e-01
Cytochrome c-mediated apoptotic response 13 3.47e-01 -1.51e-01 6.36e-01
Signaling by FGFR in disease 52 6.03e-02 1.51e-01 2.28e-01
Regulated proteolysis of p75NTR 11 3.87e-01 -1.51e-01 6.66e-01
Peptide ligand-binding receptors 102 8.66e-03 -1.50e-01 6.03e-02
Synthesis of PIPs at the ER membrane 5 5.61e-01 1.50e-01 7.83e-01
Aryl hydrocarbon receptor signalling 6 5.24e-01 1.50e-01 7.61e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 5.25e-01 1.50e-01 7.61e-01
cGMP effects 12 3.75e-01 1.48e-01 6.60e-01
Adenylate cyclase activating pathway 8 4.70e-01 -1.48e-01 7.22e-01
Heme biosynthesis 13 3.58e-01 -1.47e-01 6.44e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.11e-01 -1.47e-01 4.90e-01
Polymerase switching on the C-strand of the telomere 26 1.94e-01 1.47e-01 4.68e-01
IRAK2 mediated activation of TAK1 complex 10 4.21e-01 -1.47e-01 6.89e-01
Synthesis, secretion, and deacylation of Ghrelin 11 4.01e-01 -1.46e-01 6.75e-01
Reversal of alkylation damage by DNA dioxygenases 7 5.03e-01 1.46e-01 7.45e-01
Nicotinamide salvaging 16 3.11e-01 1.46e-01 6.02e-01
MET promotes cell motility 34 1.41e-01 -1.46e-01 3.84e-01
Regulation of TP53 Activity 153 1.86e-03 1.46e-01 1.88e-02
CLEC7A (Dectin-1) signaling 86 1.95e-02 -1.46e-01 1.06e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 5.38e-01 -1.45e-01 7.71e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 5.38e-01 -1.45e-01 7.71e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 1.22e-01 1.45e-01 3.50e-01
Telomere Extension By Telomerase 23 2.29e-01 1.45e-01 5.11e-01
Retrograde neurotrophin signalling 12 3.86e-01 -1.45e-01 6.66e-01
Nuclear Events (kinase and transcription factor activation) 54 6.60e-02 -1.45e-01 2.39e-01
Influenza Viral RNA Transcription and Replication 134 3.89e-03 -1.44e-01 3.28e-02
Formation of the Editosome 6 5.41e-01 1.44e-01 7.72e-01
mRNA Editing: C to U Conversion 6 5.41e-01 1.44e-01 7.72e-01
Axon guidance 459 1.24e-07 -1.44e-01 8.22e-06
Transcriptional regulation of white adipocyte differentiation 77 2.92e-02 1.44e-01 1.38e-01
rRNA processing 213 3.05e-04 -1.44e-01 4.99e-03
Regulation of MITF-M-dependent genes involved in pigmentation 38 1.27e-01 1.43e-01 3.61e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 4.34e-01 1.43e-01 7.00e-01
Regulation of PLK1 Activity at G2/M Transition 87 2.12e-02 1.43e-01 1.11e-01
VEGFA-VEGFR2 Pathway 92 1.80e-02 -1.43e-01 9.97e-02
Post-translational protein phosphorylation 67 4.34e-02 -1.43e-01 1.81e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 2.95e-01 1.43e-01 5.81e-01
Insulin processing 19 2.82e-01 1.43e-01 5.70e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 4.52e-02 1.43e-01 1.85e-01
APC/C-mediated degradation of cell cycle proteins 75 3.30e-02 -1.42e-01 1.51e-01
Regulation of mitotic cell cycle 75 3.30e-02 -1.42e-01 1.51e-01
Cargo recognition for clathrin-mediated endocytosis 87 2.19e-02 -1.42e-01 1.14e-01
STAT5 activation downstream of FLT3 ITD mutants 9 4.61e-01 -1.42e-01 7.19e-01
Adipogenesis 95 1.68e-02 1.42e-01 9.48e-02
Collagen degradation 42 1.12e-01 -1.42e-01 3.35e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 1.17e-01 -1.41e-01 3.42e-01
G2/M DNA replication checkpoint 5 5.86e-01 1.41e-01 7.96e-01
MAPK1/MAPK3 signaling 231 2.29e-04 -1.41e-01 4.00e-03
Respiratory syncytial virus (RSV) attachment and entry 19 2.89e-01 1.41e-01 5.73e-01
Miscellaneous substrates 8 4.92e-01 -1.40e-01 7.36e-01
Diseases of programmed cell death 58 6.49e-02 -1.40e-01 2.38e-01
Protein methylation 15 3.48e-01 -1.40e-01 6.36e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 5.70e-02 -1.40e-01 2.18e-01
IRS-related events triggered by IGF1R 36 1.49e-01 1.39e-01 4.00e-01
CREB3 factors activate genes 6 5.56e-01 -1.39e-01 7.81e-01
Negative regulation of FLT3 15 3.52e-01 -1.39e-01 6.41e-01
Response of Mtb to phagocytosis 22 2.62e-01 -1.38e-01 5.47e-01
Regulation of CDH11 Expression and Function 22 2.62e-01 1.38e-01 5.47e-01
RHO GTPases Activate ROCKs 18 3.10e-01 -1.38e-01 6.01e-01
HDR through Homologous Recombination (HRR) 68 4.93e-02 1.38e-01 1.97e-01
Nuclear Receptor transcription pathway 38 1.42e-01 1.38e-01 3.85e-01
Suppression of apoptosis 7 5.28e-01 -1.38e-01 7.61e-01
Regulation of endogenous retroelements 93 2.21e-02 1.37e-01 1.14e-01
SLC15A4:TASL-dependent IRF5 activation 6 5.60e-01 1.37e-01 7.83e-01
GABA receptor activation 36 1.54e-01 -1.37e-01 4.09e-01
Intrinsic Pathway for Apoptosis 54 8.19e-02 -1.37e-01 2.79e-01
Beta-catenin phosphorylation cascade 17 3.29e-01 -1.37e-01 6.19e-01
VLDLR internalisation and degradation 15 3.60e-01 -1.37e-01 6.45e-01
IGF1R signaling cascade 37 1.51e-01 1.37e-01 4.04e-01
SUMOylation of transcription cofactors 44 1.18e-01 1.36e-01 3.42e-01
Defective RIPK1-mediated regulated necrosis 7 5.33e-01 1.36e-01 7.67e-01
Maturation of nucleoprotein 9694631 15 3.61e-01 1.36e-01 6.47e-01
DNA Double-Strand Break Repair 137 5.96e-03 1.36e-01 4.56e-02
Signaling by VEGF 99 1.94e-02 -1.36e-01 1.06e-01
Hedgehog ‘off’ state 92 2.44e-02 -1.36e-01 1.21e-01
Centrosome maturation 81 3.51e-02 1.35e-01 1.56e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.51e-02 1.35e-01 1.56e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.03e-01 1.34e-01 4.79e-01
PKR-mediated signaling 67 5.72e-02 1.34e-01 2.18e-01
Nucleotide salvage 21 2.87e-01 -1.34e-01 5.71e-01
Nervous system development 478 5.24e-07 -1.34e-01 2.97e-05
Glycosaminoglycan metabolism 98 2.22e-02 -1.34e-01 1.14e-01
Mitotic Prometaphase 193 1.39e-03 1.33e-01 1.50e-02
Peptide hormone metabolism 53 9.35e-02 -1.33e-01 2.98e-01
RHOBTB1 GTPase cycle 23 2.69e-01 1.33e-01 5.54e-01
DNA strand elongation 32 1.93e-01 1.33e-01 4.66e-01
Caspase activation via Death Receptors in the presence of ligand 16 3.58e-01 1.33e-01 6.44e-01
Regulation of Expression and Function of Type II Classical Cadherins 24 2.60e-01 1.33e-01 5.45e-01
Regulation of Homotypic Cell-Cell Adhesion 24 2.60e-01 1.33e-01 5.45e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 5.44e-01 1.32e-01 7.72e-01
Macroautophagy 128 1.02e-02 -1.32e-01 6.60e-02
Gap junction degradation 11 4.50e-01 -1.31e-01 7.14e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 4.52e-01 1.31e-01 7.14e-01
Defective EXT2 causes exostoses 2 11 4.52e-01 1.31e-01 7.14e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 1.17e-01 1.31e-01 3.42e-01
B-WICH complex positively regulates rRNA expression 45 1.30e-01 -1.30e-01 3.66e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 3.83e-01 -1.30e-01 6.66e-01
DNA Replication Pre-Initiation 103 2.26e-02 -1.30e-01 1.15e-01
Gene expression (Transcription) 1404 3.21e-16 1.30e-01 1.55e-13
Deadenylation-dependent mRNA decay 50 1.12e-01 1.30e-01 3.35e-01
Cleavage of the damaged pyrimidine 27 2.45e-01 -1.29e-01 5.31e-01
Depyrimidination 27 2.45e-01 -1.29e-01 5.31e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 2.45e-01 -1.29e-01 5.31e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 4.38e-01 -1.29e-01 7.05e-01
EGFR downregulation 26 2.55e-01 -1.29e-01 5.40e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 3.44e-01 1.29e-01 6.35e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 2.47e-01 -1.29e-01 5.34e-01
Extracellular matrix organization 219 1.03e-03 -1.29e-01 1.23e-02
Apoptotic factor-mediated response 19 3.32e-01 -1.29e-01 6.21e-01
Sphingolipid de novo biosynthesis 35 1.89e-01 -1.28e-01 4.63e-01
Assembly and cell surface presentation of NMDA receptors 34 1.96e-01 -1.28e-01 4.69e-01
Trafficking and processing of endosomal TLR 13 4.24e-01 1.28e-01 6.92e-01
ERK/MAPK targets 22 3.00e-01 -1.28e-01 5.85e-01
MET activates PTK2 signaling 23 2.90e-01 -1.28e-01 5.75e-01
Pexophagy 10 4.85e-01 -1.27e-01 7.34e-01
G alpha (i) signalling events 196 2.16e-03 -1.27e-01 2.05e-02
Aquaporin-mediated transport 38 1.76e-01 -1.27e-01 4.43e-01
FCERI mediated NF-kB activation 130 1.28e-02 -1.26e-01 7.66e-02
RHOBTB GTPase Cycle 35 1.96e-01 1.26e-01 4.69e-01
Nuclear events stimulated by ALK signaling in cancer 33 2.09e-01 1.26e-01 4.86e-01
Constitutive Signaling by Overexpressed ERBB2 11 4.68e-01 1.26e-01 7.22e-01
Tryptophan catabolism 12 4.51e-01 1.26e-01 7.14e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.34e-01 1.26e-01 5.18e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 4.16e-01 1.26e-01 6.85e-01
Plasma lipoprotein remodeling 18 3.57e-01 -1.25e-01 6.44e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 3.79e-03 -1.25e-01 3.21e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.93e-01 -1.25e-01 4.66e-01
Synthesis of very long-chain fatty acyl-CoAs 22 3.09e-01 -1.25e-01 5.99e-01
Other semaphorin interactions 16 3.86e-01 -1.25e-01 6.66e-01
Nectin/Necl trans heterodimerization 5 6.28e-01 -1.25e-01 8.19e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 4.18e-01 1.25e-01 6.86e-01
RNA Polymerase II Transcription 1197 3.20e-13 1.25e-01 1.23e-10
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 1.06e-01 -1.25e-01 3.23e-01
Signaling by NTRK1 (TRKA) 102 2.93e-02 -1.25e-01 1.38e-01
Activation of GABAB receptors 30 2.38e-01 -1.25e-01 5.24e-01
GABA B receptor activation 30 2.38e-01 -1.25e-01 5.24e-01
Epigenetic regulation of gene expression 264 5.17e-04 1.24e-01 7.33e-03
mRNA Splicing 211 1.89e-03 1.24e-01 1.89e-02
Metabolism of carbohydrates 241 9.12e-04 -1.24e-01 1.15e-02
Processing of SMDT1 15 4.07e-01 -1.24e-01 6.78e-01
mRNA Splicing - Major Pathway 203 2.38e-03 1.24e-01 2.19e-02
Generic Transcription Pathway 1079 7.04e-12 1.24e-01 2.26e-09
KSRP (KHSRP) binds and destabilizes mRNA 17 3.78e-01 -1.24e-01 6.61e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 5.72e-01 -1.23e-01 7.90e-01
Mitotic Spindle Checkpoint 108 2.68e-02 1.23e-01 1.29e-01
rRNA processing in the nucleus and cytosol 189 3.47e-03 -1.23e-01 2.96e-02
FGFR2 ligand binding and activation 9 5.22e-01 1.23e-01 7.61e-01
Dissolution of Fibrin Clot 12 4.60e-01 -1.23e-01 7.19e-01
Cargo trafficking to the periciliary membrane 48 1.41e-01 1.23e-01 3.84e-01
Trafficking of GluR2-containing AMPA receptors 11 4.80e-01 1.23e-01 7.31e-01
Signaling by ALK fusions and activated point mutants 89 4.53e-02 1.23e-01 1.85e-01
Signaling by ALK in cancer 89 4.53e-02 1.23e-01 1.85e-01
Negative regulation of FGFR3 signaling 21 3.30e-01 -1.23e-01 6.20e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 1.03e-01 -1.23e-01 3.20e-01
Cilium Assembly 187 3.83e-03 1.23e-01 3.24e-02
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 4.27e-01 -1.23e-01 6.95e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.82e-01 -1.22e-01 7.33e-01
Acyl chain remodelling of PS 14 4.30e-01 -1.22e-01 6.96e-01
Apoptosis 158 8.17e-03 -1.22e-01 5.85e-02
G-protein beta:gamma signalling 29 2.56e-01 -1.22e-01 5.40e-01
Listeria monocytogenes entry into host cells 17 3.84e-01 -1.22e-01 6.66e-01
Metabolism 1827 5.71e-18 -1.22e-01 5.50e-15
AKT phosphorylates targets in the cytosol 14 4.31e-01 -1.21e-01 6.98e-01
Interleukin-27 signaling 11 4.86e-01 1.21e-01 7.34e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.86e-01 1.21e-01 7.34e-01
TICAM1-dependent activation of IRF3/IRF7 13 4.50e-01 -1.21e-01 7.14e-01
PI-3K cascade:FGFR1 13 4.51e-01 1.21e-01 7.14e-01
Association of TriC/CCT with target proteins during biosynthesis 35 2.17e-01 1.21e-01 4.97e-01
mRNA 3’-end processing 57 1.15e-01 1.21e-01 3.41e-01
Syndecan interactions 25 2.97e-01 -1.21e-01 5.82e-01
Platelet calcium homeostasis 22 3.28e-01 -1.20e-01 6.18e-01
Signaling by NTRKs 116 2.50e-02 -1.20e-01 1.23e-01
Defects in vitamin and cofactor metabolism 21 3.40e-01 1.20e-01 6.29e-01
CASP8 activity is inhibited 11 4.90e-01 1.20e-01 7.36e-01
Dimerization of procaspase-8 11 4.90e-01 1.20e-01 7.36e-01
Regulation by c-FLIP 11 4.90e-01 1.20e-01 7.36e-01
Pausing and recovery of Tat-mediated HIV elongation 30 2.55e-01 -1.20e-01 5.40e-01
Tat-mediated HIV elongation arrest and recovery 30 2.55e-01 -1.20e-01 5.40e-01
ARMS-mediated activation 6 6.11e-01 -1.20e-01 8.14e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.31e-01 -1.20e-01 6.21e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 3.80e-01 1.20e-01 6.63e-01
Myogenesis 20 3.55e-01 1.20e-01 6.44e-01
RUNX3 regulates p14-ARF 10 5.14e-01 -1.19e-01 7.56e-01
Stimuli-sensing channels 80 6.56e-02 -1.19e-01 2.38e-01
GPER1 signaling 38 2.04e-01 -1.19e-01 4.80e-01
Activated NTRK2 signals through RAS 6 6.14e-01 1.19e-01 8.14e-01
Activated NTRK3 signals through RAS 6 6.14e-01 1.19e-01 8.14e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.04e-01 1.19e-01 5.89e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 4.11e-01 1.19e-01 6.82e-01
Inositol phosphate metabolism 42 1.84e-01 1.18e-01 4.54e-01
Programmed Cell Death 187 5.24e-03 -1.18e-01 4.07e-02
tRNA modification in the nucleus and cytosol 43 1.80e-01 1.18e-01 4.50e-01
DNA Repair 289 5.48e-04 1.18e-01 7.60e-03
Displacement of DNA glycosylase by APEX1 9 5.40e-01 -1.18e-01 7.71e-01
Interleukin-12 signaling 44 1.76e-01 -1.18e-01 4.43e-01
Oxidative Stress Induced Senescence 77 7.39e-02 -1.18e-01 2.60e-01
NRAGE signals death through JNK 52 1.43e-01 1.17e-01 3.87e-01
Hemostasis 558 2.10e-06 -1.17e-01 1.06e-04
RND2 GTPase cycle 36 2.24e-01 1.17e-01 5.04e-01
Processing of DNA double-strand break ends 69 9.25e-02 1.17e-01 2.97e-01
ChREBP activates metabolic gene expression 7 5.92e-01 -1.17e-01 8.00e-01
Interleukin-1 processing 8 5.67e-01 -1.17e-01 7.85e-01
Keratan sulfate/keratin metabolism 28 2.84e-01 -1.17e-01 5.70e-01
Proton-coupled monocarboxylate transport 6 6.20e-01 -1.17e-01 8.16e-01
Transcriptional regulation by RUNX1 170 8.58e-03 -1.17e-01 6.03e-02
IRS-mediated signalling 35 2.32e-01 1.17e-01 5.16e-01
Downstream signaling events of B Cell Receptor (BCR) 68 9.67e-02 -1.16e-01 3.04e-01
Synthesis of PIPs at the Golgi membrane 16 4.20e-01 1.16e-01 6.89e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.62e-01 -1.16e-01 5.47e-01
Potassium Channels 64 1.08e-01 -1.16e-01 3.27e-01
L1CAM interactions 101 4.38e-02 -1.16e-01 1.82e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.22e-01 -1.16e-01 6.90e-01
Interleukin-2 family signaling 38 2.18e-01 1.15e-01 4.97e-01
FasL/ CD95L signaling 5 6.55e-01 1.15e-01 8.39e-01
MAPK family signaling cascades 263 1.27e-03 -1.15e-01 1.41e-02
RAC3 GTPase cycle 87 6.29e-02 -1.15e-01 2.34e-01
Signaling by FGFR 73 8.87e-02 -1.15e-01 2.91e-01
Signaling by FGFR1 42 1.97e-01 -1.15e-01 4.71e-01
Sema3A PAK dependent Axon repulsion 16 4.27e-01 -1.15e-01 6.95e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.52e-01 -1.15e-01 6.41e-01
Activation of PUMA and translocation to mitochondria 9 5.52e-01 1.14e-01 7.76e-01
PI3K events in ERBB4 signaling 6 6.28e-01 1.14e-01 8.19e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 2.88e-01 -1.14e-01 5.73e-01
Neurofascin interactions 5 6.60e-01 -1.14e-01 8.42e-01
Signaling by NOTCH3 42 2.03e-01 -1.14e-01 4.79e-01
Signaling by BMP 23 3.46e-01 1.14e-01 6.35e-01
Cell surface interactions at the vascular wall 173 9.98e-03 -1.14e-01 6.55e-02
Other interleukin signaling 19 3.92e-01 1.14e-01 6.68e-01
Switching of origins to a post-replicative state 79 8.16e-02 -1.13e-01 2.79e-01
Androgen biosynthesis 5 6.61e-01 -1.13e-01 8.43e-01
C-type lectin receptors (CLRs) 118 3.44e-02 -1.13e-01 1.55e-01
Amino acid transport across the plasma membrane 25 3.29e-01 1.13e-01 6.19e-01
Influenza Infection 153 1.61e-02 -1.13e-01 9.20e-02
A tetrasaccharide linker sequence is required for GAG synthesis 18 4.08e-01 -1.13e-01 6.78e-01
Formation of Incision Complex in GG-NER 43 2.02e-01 -1.12e-01 4.79e-01
Glutamate Neurotransmitter Release Cycle 19 3.97e-01 1.12e-01 6.72e-01
Class A/1 (Rhodopsin-like receptors) 177 1.00e-02 -1.12e-01 6.55e-02
PRC2 methylates histones and DNA 27 3.13e-01 -1.12e-01 6.03e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.09e-01 -1.12e-01 4.86e-01
HIV Transcription Elongation 42 2.09e-01 -1.12e-01 4.86e-01
Tat-mediated elongation of the HIV-1 transcript 42 2.09e-01 -1.12e-01 4.86e-01
Acyl chain remodelling of PG 11 5.23e-01 -1.11e-01 7.61e-01
SLBP independent Processing of Histone Pre-mRNAs 10 5.44e-01 -1.11e-01 7.72e-01
Butyrophilin (BTN) family interactions 10 5.45e-01 1.11e-01 7.72e-01
AMPK inhibits chREBP transcriptional activation activity 6 6.39e-01 -1.10e-01 8.28e-01
Erythropoietin activates STAT5 6 6.40e-01 -1.10e-01 8.29e-01
Biological oxidations 143 2.31e-02 -1.10e-01 1.17e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 6.14e-01 -1.10e-01 8.14e-01
Resolution of Sister Chromatid Cohesion 116 4.11e-02 1.10e-01 1.73e-01
Late endosomal microautophagy 30 2.98e-01 -1.10e-01 5.83e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 4.63e-01 -1.09e-01 7.19e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 4.63e-01 -1.09e-01 7.19e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 4.63e-01 -1.09e-01 7.19e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 4.63e-01 -1.09e-01 7.19e-01
Signaling by CTNNB1 phospho-site mutants 15 4.63e-01 -1.09e-01 7.19e-01
Signaling by GSK3beta mutants 15 4.63e-01 -1.09e-01 7.19e-01
RHOV GTPase cycle 36 2.56e-01 1.09e-01 5.40e-01
Signaling by ERBB2 KD Mutants 20 3.99e-01 1.09e-01 6.74e-01
Integrin cell surface interactions 65 1.30e-01 -1.09e-01 3.66e-01
Signaling by Receptor Tyrosine Kinases 443 8.74e-05 -1.09e-01 2.28e-03
PI Metabolism 79 9.59e-02 1.08e-01 3.03e-01
Zinc transporters 12 5.16e-01 1.08e-01 7.57e-01
Signaling by ERBB2 in Cancer 21 3.91e-01 1.08e-01 6.68e-01
Activation of kainate receptors upon glutamate binding 26 3.40e-01 -1.08e-01 6.29e-01
HIV Life Cycle 144 2.54e-02 1.08e-01 1.25e-01
Synthesis of Dolichyl-phosphate 6 6.47e-01 -1.08e-01 8.33e-01
STING mediated induction of host immune responses 15 4.69e-01 1.08e-01 7.22e-01
Transcriptional Regulation by E2F6 34 2.77e-01 1.08e-01 5.65e-01
G2/M DNA damage checkpoint 66 1.31e-01 1.07e-01 3.67e-01
Phase 0 - rapid depolarisation 24 3.65e-01 1.07e-01 6.51e-01
Transport and synthesis of PAPS 6 6.51e-01 -1.07e-01 8.35e-01
Formation of TC-NER Pre-Incision Complex 51 1.91e-01 -1.06e-01 4.64e-01
IRAK4 deficiency (TLR2/4) 15 4.79e-01 -1.06e-01 7.29e-01
Reactions specific to the complex N-glycan synthesis pathway 7 6.29e-01 -1.05e-01 8.19e-01
SARS-CoV-1 activates/modulates innate immune responses 40 2.49e-01 1.05e-01 5.36e-01
Signaling by SCF-KIT 40 2.49e-01 1.05e-01 5.36e-01
RNA Polymerase I Transcription Initiation 47 2.12e-01 1.05e-01 4.91e-01
Reelin signalling pathway 5 6.84e-01 -1.05e-01 8.58e-01
Keratan sulfate biosynthesis 20 4.16e-01 1.05e-01 6.85e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.99e-01 -1.04e-01 7.42e-01
E2F mediated regulation of DNA replication 22 3.97e-01 1.04e-01 6.72e-01
Signaling by FGFR2 IIIa TM 18 4.43e-01 -1.04e-01 7.09e-01
PI3K Cascade 31 3.15e-01 1.04e-01 6.04e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 6.33e-01 -1.04e-01 8.23e-01
NoRC negatively regulates rRNA expression 60 1.63e-01 -1.04e-01 4.24e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 3.89e-01 1.04e-01 6.66e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 3.89e-01 1.04e-01 6.66e-01
MET activates PI3K/AKT signaling 5 6.90e-01 1.03e-01 8.64e-01
Interleukin-4 and Interleukin-13 signaling 92 8.79e-02 -1.03e-01 2.90e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 5.05e-01 1.03e-01 7.47e-01
Phase 3 - rapid repolarisation 6 6.63e-01 1.03e-01 8.44e-01
Synthesis of diphthamide-EEF2 8 6.15e-01 -1.03e-01 8.14e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 2.55e-01 1.03e-01 5.40e-01
Striated Muscle Contraction 27 3.56e-01 -1.03e-01 6.44e-01
tRNA modification in the mitochondrion 9 5.94e-01 -1.02e-01 8.01e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 3.67e-01 -1.02e-01 6.51e-01
RHO GTPases Activate WASPs and WAVEs 35 2.97e-01 -1.02e-01 5.81e-01
Glycerophospholipid biosynthesis 105 7.11e-02 -1.02e-01 2.52e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 6.93e-01 1.02e-01 8.66e-01
Gastrulation 76 1.25e-01 -1.02e-01 3.58e-01
mRNA Splicing - Minor Pathway 50 2.13e-01 -1.02e-01 4.94e-01
EGFR Transactivation by Gastrin 7 6.41e-01 1.02e-01 8.29e-01
DNA Damage Recognition in GG-NER 38 2.79e-01 -1.02e-01 5.68e-01
Cellular responses to stimuli 778 1.52e-06 -1.01e-01 7.90e-05
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 5.28e-01 -1.01e-01 7.61e-01
Free fatty acids regulate insulin secretion 10 5.81e-01 -1.01e-01 7.93e-01
Signaling by Interleukins 390 6.49e-04 -1.01e-01 8.77e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 4.86e-01 -1.01e-01 7.34e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 4.86e-01 -1.01e-01 7.34e-01
Peroxisomal lipid metabolism 27 3.66e-01 -1.01e-01 6.51e-01
RAF-independent MAPK1/3 activation 22 4.16e-01 -1.00e-01 6.85e-01
Inhibition of Signaling by Overexpressed EGFR 5 6.99e-01 -1.00e-01 8.67e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 6.99e-01 -1.00e-01 8.67e-01
NADE modulates death signalling 5 6.99e-01 -9.99e-02 8.67e-01
Autophagy 142 4.05e-02 -9.96e-02 1.72e-01
Nucleotide biosynthesis 12 5.52e-01 9.92e-02 7.76e-01
Na+/Cl- dependent neurotransmitter transporters 8 6.27e-01 -9.92e-02 8.19e-01
Nef Mediated CD8 Down-regulation 7 6.51e-01 -9.88e-02 8.35e-01
Leading Strand Synthesis 14 5.23e-01 9.87e-02 7.61e-01
Polymerase switching 14 5.23e-01 9.87e-02 7.61e-01
Metabolism of nucleotides 85 1.16e-01 -9.86e-02 3.42e-01
MECP2 regulates neuronal receptors and channels 14 5.23e-01 9.85e-02 7.61e-01
Budding and maturation of HIV virion 26 3.85e-01 -9.84e-02 6.66e-01
ADP signalling through P2Y purinoceptor 1 21 4.35e-01 -9.84e-02 7.02e-01
Signaling by MET 68 1.61e-01 -9.82e-02 4.21e-01
Signaling by CSF3 (G-CSF) 29 3.60e-01 -9.82e-02 6.46e-01
Homology Directed Repair 110 7.63e-02 9.78e-02 2.66e-01
ATF6 (ATF6-alpha) activates chaperones 12 5.57e-01 9.78e-02 7.81e-01
Serine biosynthesis 8 6.32e-01 -9.77e-02 8.22e-01
Diseases of metabolism 204 1.63e-02 -9.76e-02 9.27e-02
HSF1 activation 26 3.90e-01 9.74e-02 6.66e-01
DAP12 interactions 39 2.93e-01 9.73e-02 5.78e-01
RHOH GTPase cycle 33 3.34e-01 -9.71e-02 6.25e-01
Generation of second messenger molecules 38 3.01e-01 9.70e-02 5.85e-01
Signal amplification 28 3.74e-01 -9.70e-02 6.60e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 3.76e-01 -9.68e-02 6.60e-01
Cellular responses to stress 697 1.37e-05 -9.66e-02 5.27e-04
Cellular responses to mechanical stimuli 82 1.30e-01 -9.66e-02 3.66e-01
Response of endothelial cells to shear stress 82 1.30e-01 -9.66e-02 3.66e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 3.94e-01 -9.66e-02 6.69e-01
RHOJ GTPase cycle 49 2.43e-01 -9.65e-02 5.29e-01
Zinc influx into cells by the SLC39 gene family 9 6.17e-01 -9.62e-02 8.14e-01
Hedgehog ‘on’ state 66 1.77e-01 -9.60e-02 4.45e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.88e-01 -9.60e-02 6.66e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.88e-01 -9.60e-02 6.66e-01
Tandem pore domain potassium channels 5 7.10e-01 9.60e-02 8.72e-01
Degradation of the extracellular matrix 96 1.05e-01 -9.57e-02 3.23e-01
Regulation of Complement cascade 97 1.05e-01 -9.52e-02 3.23e-01
Notch-HLH transcription pathway 28 3.85e-01 9.49e-02 6.66e-01
Dopamine Neurotransmitter Release Cycle 18 4.86e-01 9.48e-02 7.34e-01
CaMK IV-mediated phosphorylation of CREB 9 6.23e-01 9.47e-02 8.16e-01
Biotin transport and metabolism 11 5.87e-01 -9.46e-02 7.96e-01
PKA-mediated phosphorylation of CREB 17 5.00e-01 -9.45e-02 7.42e-01
Defective B4GALT7 causes EDS, progeroid type 12 5.71e-01 9.45e-02 7.90e-01
Negative regulation of FGFR4 signaling 22 4.43e-01 -9.44e-02 7.09e-01
DNA Replication 128 6.52e-02 -9.44e-02 2.38e-01
Regulation of TLR by endogenous ligand 15 5.27e-01 -9.43e-02 7.61e-01
Signaling by Activin 13 5.57e-01 -9.41e-02 7.81e-01
RNA polymerase II transcribes snRNA genes 71 1.70e-01 9.41e-02 4.36e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 6.25e-01 9.40e-02 8.17e-01
NCAM1 interactions 26 4.07e-01 9.39e-02 6.78e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 2.56e-01 9.39e-02 5.40e-01
Phospholipase C-mediated cascade: FGFR1 8 6.47e-01 -9.35e-02 8.33e-01
Synthesis of PIPs at the plasma membrane 52 2.45e-01 9.32e-02 5.31e-01
Cyclin D associated events in G1 47 2.70e-01 -9.30e-02 5.54e-01
G1 Phase 47 2.70e-01 -9.30e-02 5.54e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 7.19e-01 -9.28e-02 8.75e-01
WNT5A-dependent internalization of FZD4 13 5.62e-01 9.28e-02 7.83e-01
Fanconi Anemia Pathway 36 3.36e-01 9.27e-02 6.25e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 6.95e-01 9.25e-02 8.67e-01
SARS-CoV-1-host interactions 94 1.21e-01 -9.25e-02 3.49e-01
RNA Polymerase III Transcription Termination 22 4.53e-01 -9.24e-02 7.15e-01
Signaling by NOTCH 173 3.61e-02 -9.24e-02 1.59e-01
Pregnenolone biosynthesis 10 6.13e-01 -9.24e-02 8.14e-01
RAB geranylgeranylation 63 2.05e-01 -9.23e-02 4.82e-01
SUMOylation of DNA methylation proteins 16 5.23e-01 9.22e-02 7.61e-01
Receptor-type tyrosine-protein phosphatases 11 5.98e-01 -9.19e-02 8.04e-01
LDL clearance 17 5.14e-01 -9.15e-02 7.56e-01
RND1 GTPase cycle 36 3.43e-01 9.13e-02 6.34e-01
Scavenging of heme from plasma 71 1.84e-01 -9.12e-02 4.53e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 4.92e-01 -9.11e-02 7.36e-01
APC-Cdc20 mediated degradation of Nek2A 26 4.21e-01 -9.11e-02 6.89e-01
CTLA4 inhibitory signaling 21 4.70e-01 -9.10e-02 7.22e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 5.17e-01 9.08e-02 7.58e-01
Synthesis of PI 5 7.26e-01 9.06e-02 8.80e-01
MAP kinase activation 63 2.15e-01 -9.03e-02 4.95e-01
EML4 and NUDC in mitotic spindle formation 107 1.08e-01 9.01e-02 3.27e-01
HS-GAG degradation 20 4.86e-01 -8.99e-02 7.34e-01
Regulation of signaling by CBL 22 4.66e-01 8.99e-02 7.20e-01
RAS signaling downstream of NF1 loss-of-function variants 7 6.81e-01 8.99e-02 8.58e-01
Late Phase of HIV Life Cycle 131 7.59e-02 8.98e-02 2.65e-01
ABC transporters in lipid homeostasis 14 5.61e-01 8.97e-02 7.83e-01
Late SARS-CoV-2 Infection Events 64 2.15e-01 -8.95e-02 4.95e-01
Sensory processing of sound by inner hair cells of the cochlea 54 2.55e-01 8.95e-02 5.40e-01
PIWI-interacting RNA (piRNA) biogenesis 23 4.58e-01 -8.94e-02 7.18e-01
Triglyceride catabolism 15 5.49e-01 -8.94e-02 7.75e-01
Regulation of IFNG signaling 14 5.63e-01 -8.94e-02 7.83e-01
CD28 dependent PI3K/Akt signaling 22 4.68e-01 8.93e-02 7.22e-01
Metalloprotease DUBs 20 4.89e-01 -8.93e-02 7.36e-01
Type I hemidesmosome assembly 8 6.62e-01 8.91e-02 8.44e-01
RHO GTPases activate PAKs 20 4.91e-01 -8.90e-02 7.36e-01
Mitochondrial unfolded protein response (UPRmt) 17 5.27e-01 8.86e-02 7.61e-01
MET activates RAS signaling 10 6.28e-01 -8.85e-02 8.19e-01
Organelle biogenesis and maintenance 278 1.12e-02 8.84e-02 7.00e-02
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.75e-01 -8.80e-02 6.60e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 6.88e-01 -8.78e-02 8.62e-01
rRNA modification in the nucleus and cytosol 60 2.40e-01 8.76e-02 5.25e-01
Platelet homeostasis 69 2.09e-01 -8.75e-02 4.86e-01
Signal regulatory protein family interactions 13 5.86e-01 -8.73e-02 7.96e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 5.86e-01 -8.72e-02 7.96e-01
Activation of HOX genes during differentiation 70 2.07e-01 -8.72e-02 4.85e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 2.07e-01 -8.72e-02 4.85e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 5.34e-01 8.71e-02 7.68e-01
Alternative complement activation 5 7.36e-01 -8.70e-02 8.84e-01
Metabolism of fat-soluble vitamins 28 4.28e-01 -8.66e-02 6.95e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.68e-01 8.63e-02 5.54e-01
PTEN Regulation 127 9.36e-02 -8.62e-02 2.98e-01
VEGFR2 mediated vascular permeability 25 4.56e-01 -8.61e-02 7.17e-01
APC truncation mutants have impaired AXIN binding 14 5.78e-01 -8.59e-02 7.90e-01
AXIN missense mutants destabilize the destruction complex 14 5.78e-01 -8.59e-02 7.90e-01
Signaling by AMER1 mutants 14 5.78e-01 -8.59e-02 7.90e-01
Signaling by APC mutants 14 5.78e-01 -8.59e-02 7.90e-01
Signaling by AXIN mutants 14 5.78e-01 -8.59e-02 7.90e-01
Truncations of AMER1 destabilize the destruction complex 14 5.78e-01 -8.59e-02 7.90e-01
Regulation of CDH11 gene transcription 5 7.40e-01 -8.57e-02 8.85e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.15e-01 8.57e-02 6.04e-01
Maturation of spike protein 9683686 5 7.40e-01 -8.56e-02 8.85e-01
Signaling by FGFR2 61 2.48e-01 -8.55e-02 5.35e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.18e-01 -8.55e-02 6.86e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.27e-01 -8.54e-02 6.18e-01
Nephrin family interactions 20 5.10e-01 8.51e-02 7.53e-01
Downregulation of ERBB2 signaling 24 4.72e-01 -8.48e-02 7.24e-01
EPH-Ephrin signaling 81 1.87e-01 -8.48e-02 4.59e-01
Transport of small molecules 556 6.31e-04 -8.48e-02 8.63e-03
Visual phototransduction 61 2.53e-01 -8.47e-02 5.38e-01
Sialic acid metabolism 28 4.38e-01 8.47e-02 7.05e-01
Signaling by BRAF and RAF1 fusions 60 2.58e-01 -8.44e-02 5.44e-01
Defective HLCS causes multiple carboxylase deficiency 7 6.99e-01 8.43e-02 8.67e-01
Negative regulation of FGFR2 signaling 24 4.76e-01 -8.40e-02 7.28e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 1.64e-01 -8.36e-02 4.26e-01
Nef and signal transduction 8 6.82e-01 8.35e-02 8.58e-01
Regulation of HMOX1 expression and activity 5 7.46e-01 8.35e-02 8.89e-01
MITF-M-dependent gene expression 84 1.86e-01 8.35e-02 4.58e-01
RHOBTB3 ATPase cycle 10 6.48e-01 -8.34e-02 8.33e-01
Complement cascade 101 1.47e-01 -8.34e-02 3.96e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 7.47e-01 8.32e-02 8.89e-01
Activation of Matrix Metalloproteinases 22 5.00e-01 -8.32e-02 7.42e-01
Mitotic Prophase 96 1.59e-01 8.31e-02 4.19e-01
RNA Polymerase III Chain Elongation 18 5.42e-01 -8.31e-02 7.72e-01
HIV elongation arrest and recovery 32 4.16e-01 -8.30e-02 6.85e-01
Pausing and recovery of HIV elongation 32 4.16e-01 -8.30e-02 6.85e-01
Signaling by Hedgehog 121 1.15e-01 -8.29e-02 3.41e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.03e-01 8.28e-02 6.75e-01
FGFR2b ligand binding and activation 6 7.28e-01 8.21e-02 8.80e-01
Cell-cell junction organization 57 2.85e-01 8.19e-02 5.70e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 5.18e-01 8.15e-02 7.58e-01
Mitochondrial Uncoupling 6 7.30e-01 8.14e-02 8.80e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 5.50e-01 8.14e-02 7.75e-01
Nitric oxide stimulates guanylate cyclase 15 5.85e-01 8.14e-02 7.96e-01
Muscle contraction 145 9.11e-02 -8.13e-02 2.94e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 6.73e-01 8.12e-02 8.53e-01
Transcriptional Regulation by VENTX 39 3.82e-01 8.10e-02 6.65e-01
Post-translational modification: synthesis of GPI-anchored proteins 60 2.79e-01 -8.07e-02 5.68e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 6.15e-01 8.06e-02 8.14e-01
Regulation of innate immune responses to cytosolic DNA 14 6.03e-01 -8.02e-02 8.09e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 6.17e-01 -8.02e-02 8.14e-01
Lewis blood group biosynthesis 13 6.17e-01 -8.01e-02 8.14e-01
RIP-mediated NFkB activation via ZBP1 17 5.68e-01 8.00e-02 7.87e-01
Leishmania infection 213 4.49e-02 -7.97e-02 1.85e-01
Parasitic Infection Pathways 213 4.49e-02 -7.97e-02 1.85e-01
Bacterial Infection Pathways 65 2.67e-01 -7.96e-02 5.52e-01
Translation of Structural Proteins 9683701 29 4.59e-01 7.94e-02 7.18e-01
Class I peroxisomal membrane protein import 20 5.39e-01 7.94e-02 7.71e-01
Signaling by LTK in cancer 7 7.16e-01 7.94e-02 8.73e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 5.61e-01 -7.92e-02 7.83e-01
Erythropoietin activates RAS 13 6.21e-01 -7.92e-02 8.16e-01
Tight junction interactions 17 5.74e-01 7.88e-02 7.90e-01
Adherens junctions interactions 38 4.01e-01 7.87e-02 6.75e-01
RNA Polymerase II Transcription Termination 66 2.70e-01 7.85e-02 5.54e-01
GPCR ligand binding 245 3.46e-02 -7.84e-02 1.55e-01
Interleukin-17 signaling 68 2.64e-01 -7.84e-02 5.48e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 5.34e-01 -7.83e-02 7.68e-01
Oncogenic MAPK signaling 76 2.40e-01 -7.80e-02 5.25e-01
Beta-catenin independent WNT signaling 126 1.32e-01 -7.77e-02 3.68e-01
mRNA Capping 29 4.71e-01 -7.74e-02 7.22e-01
O-linked glycosylation of mucins 47 3.59e-01 -7.73e-02 6.45e-01
Interleukin receptor SHC signaling 23 5.21e-01 7.73e-02 7.61e-01
CDH11 homotypic and heterotypic interactions 5 7.65e-01 7.72e-02 9.00e-01
RNA Polymerase I Promoter Clearance 64 2.86e-01 -7.72e-02 5.70e-01
RNA Polymerase I Transcription 64 2.86e-01 -7.72e-02 5.70e-01
The NLRP3 inflammasome 16 5.93e-01 -7.71e-02 8.00e-01
Processing of Intronless Pre-mRNAs 20 5.51e-01 7.70e-02 7.76e-01
Signaling by TGFB family members 137 1.20e-01 7.69e-02 3.49e-01
Cell Cycle 611 1.19e-03 7.68e-02 1.36e-02
Protein folding 83 2.27e-01 -7.68e-02 5.09e-01
Gene Silencing by RNA 87 2.17e-01 7.65e-02 4.97e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.71e-01 -7.63e-02 4.36e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 1.71e-01 -7.63e-02 4.36e-01
G1/S-Specific Transcription 29 4.77e-01 7.63e-02 7.29e-01
Presynaptic depolarization and calcium channel opening 8 7.09e-01 7.63e-02 8.72e-01
Sensory processing of sound 58 3.17e-01 7.60e-02 6.05e-01
G beta:gamma signalling through PI3Kgamma 22 5.37e-01 -7.60e-02 7.71e-01
ADORA2B mediated anti-inflammatory cytokines production 36 4.32e-01 -7.57e-02 6.98e-01
Vitamin C (ascorbate) metabolism 8 7.12e-01 7.55e-02 8.72e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 7.70e-01 -7.55e-02 9.01e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 7.13e-01 7.51e-02 8.72e-01
MicroRNA (miRNA) biogenesis 24 5.25e-01 -7.50e-02 7.61e-01
FGFR1c ligand binding and activation 8 7.14e-01 7.49e-02 8.72e-01
NCAM signaling for neurite out-growth 47 3.74e-01 7.49e-02 6.60e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 6.04e-01 7.49e-02 8.09e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 3.57e-01 -7.46e-02 6.44e-01
PERK regulates gene expression 31 4.74e-01 -7.42e-02 7.27e-01
Ion channel transport 141 1.29e-01 -7.41e-02 3.64e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 4.29e-01 -7.41e-02 6.96e-01
Nucleosome assembly 38 4.29e-01 -7.41e-02 6.96e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 51 3.61e-01 -7.40e-02 6.46e-01
Signaling by FGFR2 in disease 33 4.64e-01 7.37e-02 7.19e-01
Protein hydroxylation 17 5.99e-01 -7.36e-02 8.04e-01
Fc epsilon receptor (FCERI) signaling 180 8.86e-02 -7.36e-02 2.91e-01
Recruitment of NuMA to mitotic centrosomes 88 2.33e-01 7.35e-02 5.17e-01
Loss of Function of TGFBR1 in Cancer 7 7.37e-01 7.32e-02 8.84e-01
Transcriptional regulation of testis differentiation 5 7.77e-01 7.30e-02 9.04e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 5.36e-01 -7.30e-02 7.70e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 4.97e-01 -7.28e-02 7.42e-01
Vitamin B5 (pantothenate) metabolism 20 5.73e-01 -7.28e-02 7.90e-01
Defective pyroptosis 27 5.13e-01 -7.28e-02 7.56e-01
RHO GTPase Effectors 259 4.43e-02 -7.26e-02 1.84e-01
Early SARS-CoV-2 Infection Events 32 4.78e-01 7.25e-02 7.29e-01
Suppression of phagosomal maturation 12 6.64e-01 -7.24e-02 8.44e-01
Transcriptional Regulation by NPAS4 27 5.16e-01 7.22e-02 7.57e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 3.77e-01 -7.22e-02 6.61e-01
Retrograde transport at the Trans-Golgi-Network 49 3.82e-01 7.21e-02 6.65e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.79e-01 -7.20e-02 8.58e-01
Signaling by WNT in cancer 30 4.95e-01 -7.19e-02 7.40e-01
DNA Double Strand Break Response 47 3.94e-01 7.18e-02 6.69e-01
Toll Like Receptor 2 (TLR2) Cascade 109 1.96e-01 -7.17e-02 4.69e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 1.96e-01 -7.17e-02 4.69e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 3.58e-01 -7.17e-02 6.44e-01
Apoptosis induced DNA fragmentation 10 6.95e-01 -7.16e-02 8.67e-01
Aspartate and asparagine metabolism 9 7.11e-01 -7.14e-02 8.72e-01
TRAF6 mediated NF-kB activation 23 5.54e-01 7.14e-02 7.78e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.10e-01 7.12e-02 4.86e-01
Signaling by the B Cell Receptor (BCR) 151 1.31e-01 -7.11e-02 3.67e-01
TCF dependent signaling in response to WNT 152 1.30e-01 -7.11e-02 3.66e-01
Integration of energy metabolism 88 2.49e-01 -7.11e-02 5.36e-01
Sensory perception of taste 22 5.65e-01 7.10e-02 7.84e-01
Signaling by NTRK2 (TRKB) 20 5.83e-01 7.09e-02 7.94e-01
Collagen chain trimerization 27 5.25e-01 7.06e-02 7.61e-01
tRNA processing 128 1.68e-01 7.06e-02 4.33e-01
Branched-chain amino acid catabolism 21 5.77e-01 -7.04e-02 7.90e-01
Folding of actin by CCT/TriC 10 7.01e-01 -7.01e-02 8.68e-01
Mitochondrial iron-sulfur cluster biogenesis 13 6.63e-01 -6.98e-02 8.44e-01
G alpha (12/13) signalling events 68 3.19e-01 6.98e-02 6.09e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.46e-01 6.97e-02 7.73e-01
Initiation of Nuclear Envelope (NE) Reformation 19 5.99e-01 6.97e-02 8.04e-01
NOD1/2 Signaling Pathway 36 4.70e-01 -6.95e-02 7.22e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 5.24e-01 6.95e-02 7.61e-01
Reversible hydration of carbon dioxide 8 7.36e-01 -6.89e-02 8.84e-01
Signaling by Insulin receptor 63 3.44e-01 -6.89e-02 6.35e-01
TRP channels 22 5.76e-01 -6.88e-02 7.90e-01
Phase 4 - resting membrane potential 9 7.21e-01 -6.88e-02 8.76e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 7.53e-01 -6.88e-02 8.91e-01
Vitamin B2 (riboflavin) metabolism 6 7.71e-01 -6.87e-02 9.01e-01
Glucagon signaling in metabolic regulation 26 5.44e-01 -6.87e-02 7.72e-01
Regulation of TNFR1 signaling 47 4.16e-01 -6.86e-02 6.85e-01
Paracetamol ADME 19 6.05e-01 -6.85e-02 8.09e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 4.68e-01 6.80e-02 7.22e-01
Translesion Synthesis by POLH 18 6.18e-01 -6.79e-02 8.15e-01
Long-term potentiation 18 6.19e-01 -6.77e-02 8.15e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 2.83e-01 -6.74e-02 5.70e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 2.83e-01 -6.74e-02 5.70e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 2.83e-01 -6.74e-02 5.70e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 3.01e-01 6.74e-02 5.85e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 4.41e-01 6.71e-02 7.09e-01
trans-Golgi Network Vesicle Budding 69 3.38e-01 -6.67e-02 6.27e-01
Cytoprotection by HMOX1 53 4.01e-01 -6.66e-02 6.75e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 6.17e-01 6.63e-02 8.14e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 6.00e-01 -6.61e-02 8.05e-01
PIP3 activates AKT signaling 234 8.18e-02 -6.60e-02 2.79e-01
Assembly of collagen fibrils and other multimeric structures 42 4.59e-01 -6.60e-02 7.18e-01
Role of LAT2/NTAL/LAB on calcium mobilization 78 3.14e-01 -6.59e-02 6.03e-01
Phase I - Functionalization of compounds 68 3.48e-01 -6.58e-02 6.36e-01
Cytosolic iron-sulfur cluster assembly 13 6.82e-01 -6.56e-02 8.58e-01
Downstream TCR signaling 89 2.86e-01 -6.55e-02 5.70e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 7.81e-01 6.55e-02 9.06e-01
Neurexins and neuroligins 38 4.86e-01 6.53e-02 7.34e-01
Lipophagy 7 7.65e-01 6.52e-02 9.00e-01
Negative epigenetic regulation of rRNA expression 63 3.72e-01 -6.50e-02 6.58e-01
Reduction of cytosolic Ca++ levels 9 7.36e-01 -6.48e-02 8.84e-01
DNA Damage Bypass 47 4.42e-01 6.48e-02 7.09e-01
Wax and plasmalogen biosynthesis 5 8.03e-01 -6.43e-02 9.16e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 6.58e-01 6.40e-02 8.41e-01
Defective B3GAT3 causes JDSSDHD 12 7.01e-01 6.40e-02 8.68e-01
Cell Cycle, Mitotic 488 1.58e-02 6.38e-02 9.12e-02
PTK6 promotes HIF1A stabilization 6 7.87e-01 -6.37e-02 9.09e-01
Negative regulation of the PI3K/AKT network 91 2.95e-01 -6.35e-02 5.81e-01
Plasma lipoprotein assembly 10 7.28e-01 6.35e-02 8.80e-01
CD28 dependent Vav1 pathway 12 7.04e-01 6.34e-02 8.70e-01
Nucleotide catabolism 28 5.63e-01 -6.31e-02 7.83e-01
Formation of definitive endoderm 9 7.43e-01 6.31e-02 8.87e-01
G2 Phase 5 8.08e-01 -6.29e-02 9.18e-01
Cellular hexose transport 15 6.74e-01 6.26e-02 8.53e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 6.46e-01 6.26e-02 8.33e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 6.46e-01 6.26e-02 8.33e-01
Interleukin-37 signaling 19 6.37e-01 -6.25e-02 8.26e-01
G beta:gamma signalling through CDC42 17 6.55e-01 -6.25e-02 8.39e-01
Downstream signal transduction 27 5.75e-01 6.24e-02 7.90e-01
Release of apoptotic factors from the mitochondria 6 7.92e-01 -6.23e-02 9.13e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 6.87e-01 -6.22e-02 8.62e-01
The phototransduction cascade 27 5.79e-01 -6.17e-02 7.91e-01
Diseases associated with glycosylation precursor biosynthesis 15 6.81e-01 -6.13e-02 8.58e-01
Synthesis of PE 12 7.13e-01 -6.12e-02 8.72e-01
Immune System 1841 1.34e-05 -6.12e-02 5.27e-04
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 5.49e-01 -6.12e-02 7.75e-01
Formation of the beta-catenin:TCF transactivating complex 44 4.83e-01 6.11e-02 7.34e-01
Retinoid metabolism and transport 25 5.98e-01 -6.09e-02 8.04e-01
FGFR1 ligand binding and activation 10 7.39e-01 -6.07e-02 8.85e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.06e-01 6.05e-02 8.71e-01
Developmental Biology 924 1.83e-03 -6.05e-02 1.86e-02
Interleukin-10 signaling 39 5.15e-01 -6.03e-02 7.56e-01
Downstream signaling of activated FGFR1 22 6.25e-01 6.03e-02 8.17e-01
Vitamin D (calciferol) metabolism 11 7.30e-01 6.00e-02 8.80e-01
Nuclear Envelope (NE) Reassembly 68 3.92e-01 6.00e-02 6.68e-01
Miscellaneous transport and binding events 20 6.43e-01 -5.98e-02 8.31e-01
Synthesis of DNA 108 2.84e-01 -5.97e-02 5.70e-01
Intracellular signaling by second messengers 267 9.39e-02 -5.96e-02 2.98e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 5.99e-01 5.95e-02 8.04e-01
Adenylate cyclase inhibitory pathway 11 7.33e-01 -5.95e-02 8.82e-01
Clathrin-mediated endocytosis 126 2.49e-01 -5.94e-02 5.36e-01
Signaling by activated point mutants of FGFR1 5 8.18e-01 5.94e-02 9.23e-01
Meiosis 67 4.02e-01 5.92e-02 6.75e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 7.12e-01 5.91e-02 8.72e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 4.57e-01 -5.90e-02 7.17e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 4.57e-01 -5.90e-02 7.17e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 4.57e-01 -5.90e-02 7.17e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 4.57e-01 -5.90e-02 7.17e-01
Signaling by NOTCH1 in Cancer 53 4.57e-01 -5.90e-02 7.17e-01
Collagen formation 64 4.15e-01 -5.89e-02 6.85e-01
NrCAM interactions 6 8.03e-01 -5.89e-02 9.16e-01
Maternal to zygotic transition (MZT) 72 3.89e-01 -5.87e-02 6.66e-01
Chaperonin-mediated protein folding 77 3.75e-01 -5.84e-02 6.60e-01
Transcription of E2F targets under negative control by DREAM complex 19 6.60e-01 5.83e-02 8.42e-01
Post NMDA receptor activation events 64 4.20e-01 -5.82e-02 6.89e-01
Interleukin-12 family signaling 53 4.63e-01 -5.82e-02 7.19e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 3.57e-01 -5.82e-02 6.44e-01
HS-GAG biosynthesis 21 6.46e-01 5.79e-02 8.33e-01
Regulation of pyruvate metabolism 32 5.72e-01 -5.77e-02 7.90e-01
Nicotinate metabolism 27 6.04e-01 5.76e-02 8.09e-01
Transport of bile salts and organic acids, metal ions and amine compounds 53 4.68e-01 -5.76e-02 7.22e-01
Purine salvage 12 7.30e-01 5.75e-02 8.80e-01
Metabolism of proteins 1775 6.06e-05 -5.73e-02 1.82e-03
Formation of the active cofactor, UDP-glucuronate 5 8.25e-01 -5.72e-02 9.27e-01
Interleukin-7 signaling 21 6.50e-01 -5.72e-02 8.35e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 5.59e-01 -5.70e-02 7.83e-01
Toll Like Receptor 4 (TLR4) Cascade 138 2.49e-01 -5.69e-02 5.36e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 7.69e-01 5.66e-02 9.01e-01
Ca-dependent events 30 5.92e-01 -5.65e-02 8.00e-01
Regulation of CDH11 function 9 7.70e-01 -5.64e-02 9.01e-01
Activation of gene expression by SREBF (SREBP) 42 5.27e-01 5.64e-02 7.61e-01
EGFR interacts with phospholipase C-gamma 6 8.11e-01 -5.63e-02 9.18e-01
G1/S Transition 120 2.87e-01 -5.63e-02 5.71e-01
FRS-mediated FGFR1 signaling 15 7.06e-01 5.62e-02 8.71e-01
Fatty acyl-CoA biosynthesis 35 5.65e-01 -5.62e-02 7.84e-01
Triglyceride metabolism 24 6.35e-01 -5.60e-02 8.24e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 7.99e-01 -5.56e-02 9.15e-01
TCR signaling 110 3.14e-01 -5.56e-02 6.03e-01
Synaptic adhesion-like molecules 17 6.92e-01 5.54e-02 8.66e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 5.25e-01 5.54e-02 7.61e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 6.76e-01 5.54e-02 8.54e-01
Methylation 13 7.30e-01 5.53e-02 8.80e-01
Mitotic G1 phase and G1/S transition 138 2.63e-01 -5.52e-02 5.47e-01
Nef Mediated CD4 Down-regulation 9 7.76e-01 -5.48e-02 9.03e-01
Plasma lipoprotein clearance 32 5.92e-01 -5.47e-02 8.00e-01
ER Quality Control Compartment (ERQC) 21 6.64e-01 -5.47e-02 8.44e-01
GAB1 signalosome 14 7.23e-01 5.46e-02 8.79e-01
RAF activation 33 5.89e-01 -5.44e-02 7.98e-01
Tie2 Signaling 16 7.07e-01 5.43e-02 8.71e-01
MITF-M-regulated melanocyte development 113 3.19e-01 5.43e-02 6.08e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.21e-01 5.40e-02 8.16e-01
TAK1-dependent IKK and NF-kappa-B activation 43 5.41e-01 -5.39e-02 7.72e-01
Initial triggering of complement 80 4.06e-01 -5.38e-02 6.77e-01
Maturation of spike protein 9694548 36 5.77e-01 -5.37e-02 7.90e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 7.48e-01 5.37e-02 8.89e-01
Signaling by TGF-beta Receptor Complex 90 3.82e-01 5.33e-02 6.65e-01
FGFR1b ligand binding and activation 5 8.37e-01 5.32e-02 9.33e-01
TP53 Regulates Transcription of Cell Death Genes 43 5.46e-01 -5.32e-02 7.73e-01
Organic anion transporters 7 8.08e-01 5.30e-02 9.18e-01
MTOR signalling 39 5.69e-01 -5.26e-02 7.88e-01
Cell death signalling via NRAGE, NRIF and NADE 69 4.56e-01 5.19e-02 7.17e-01
Intraflagellar transport 47 5.40e-01 5.17e-02 7.71e-01
RUNX3 regulates NOTCH signaling 14 7.38e-01 5.16e-02 8.84e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 188 2.29e-01 -5.09e-02 5.11e-01
NFE2L2 regulating tumorigenic genes 11 7.71e-01 5.07e-02 9.01e-01
Classical antibody-mediated complement activation 70 4.65e-01 -5.05e-02 7.20e-01
Pre-NOTCH Transcription and Translation 47 5.50e-01 -5.05e-02 7.75e-01
Creation of C4 and C2 activators 72 4.59e-01 -5.05e-02 7.18e-01
Termination of translesion DNA synthesis 32 6.22e-01 5.04e-02 8.16e-01
CD22 mediated BCR regulation 59 5.06e-01 -5.01e-02 7.47e-01
GRB2 events in ERBB2 signaling 11 7.74e-01 -4.99e-02 9.03e-01
Dual Incision in GG-NER 41 5.81e-01 -4.98e-02 7.93e-01
MyD88 cascade initiated on plasma membrane 95 4.03e-01 -4.97e-02 6.75e-01
Toll Like Receptor 10 (TLR10) Cascade 95 4.03e-01 -4.97e-02 6.75e-01
Toll Like Receptor 5 (TLR5) Cascade 95 4.03e-01 -4.97e-02 6.75e-01
Lysine catabolism 11 7.76e-01 -4.96e-02 9.03e-01
Chromosome Maintenance 103 3.88e-01 4.93e-02 6.66e-01
COPI-mediated anterograde transport 92 4.15e-01 -4.92e-02 6.85e-01
ZBP1(DAI) mediated induction of type I IFNs 20 7.04e-01 4.91e-02 8.70e-01
VxPx cargo-targeting to cilium 19 7.11e-01 4.91e-02 8.72e-01
Collagen biosynthesis and modifying enzymes 46 5.65e-01 -4.90e-02 7.84e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 6.12e-01 4.88e-02 8.14e-01
Formation of the nephric duct 8 8.13e-01 4.83e-02 9.20e-01
RHO GTPases Activate Formins 128 3.46e-01 4.82e-02 6.36e-01
Signaling by GPCR 446 8.19e-02 -4.81e-02 2.79e-01
GPCR downstream signalling 399 9.96e-02 -4.80e-02 3.11e-01
VEGFR2 mediated cell proliferation 18 7.25e-01 -4.80e-02 8.80e-01
Signaling by Retinoic Acid 29 6.59e-01 -4.73e-02 8.42e-01
Diseases of mitotic cell cycle 38 6.14e-01 4.73e-02 8.14e-01
Anti-inflammatory response favouring Leishmania parasite infection 133 3.48e-01 -4.71e-02 6.36e-01
Leishmania parasite growth and survival 133 3.48e-01 -4.71e-02 6.36e-01
Signaling by EGFR in Cancer 22 7.04e-01 4.68e-02 8.70e-01
Glucagon-type ligand receptors 20 7.17e-01 4.67e-02 8.74e-01
Dual incision in TC-NER 63 5.22e-01 -4.67e-02 7.61e-01
TGF-beta receptor signaling activates SMADs 45 5.90e-01 -4.64e-02 7.99e-01
Metabolism of lipids 641 4.51e-02 -4.64e-02 1.85e-01
Nonhomologous End-Joining (NHEJ) 40 6.14e-01 4.61e-02 8.14e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 7.78e-01 -4.52e-02 9.04e-01
HCMV Early Events 84 4.76e-01 4.50e-02 7.28e-01
Intra-Golgi traffic 43 6.14e-01 4.45e-02 8.14e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 7.66e-01 -4.45e-02 9.00e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 7.74e-01 4.44e-02 9.03e-01
RNA Polymerase II Pre-transcription Events 77 5.02e-01 4.42e-02 7.45e-01
TP53 Regulates Transcription of DNA Repair Genes 61 5.52e-01 4.41e-02 7.76e-01
SHC1 events in ERBB2 signaling 17 7.54e-01 -4.40e-02 8.91e-01
Diseases of branched-chain amino acid catabolism 13 7.86e-01 -4.35e-02 9.09e-01
Scavenging by Class A Receptors 12 7.94e-01 -4.35e-02 9.14e-01
Kinesins 51 5.91e-01 -4.35e-02 8.00e-01
M Phase 346 1.68e-01 4.31e-02 4.33e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 4.99e-01 -4.27e-02 7.42e-01
Pyruvate metabolism 44 6.24e-01 -4.27e-02 8.17e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 5.00e-01 -4.26e-02 7.42e-01
Glycolysis 68 5.44e-01 4.25e-02 7.72e-01
Neurotransmitter receptors and postsynaptic signal transmission 139 3.87e-01 -4.25e-02 6.66e-01
Lysosphingolipid and LPA receptors 11 8.07e-01 -4.24e-02 9.18e-01
Ion homeostasis 42 6.34e-01 -4.24e-02 8.24e-01
Signaling by FLT3 ITD and TKD mutants 15 7.76e-01 4.24e-02 9.03e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 8.00e-01 4.23e-02 9.15e-01
EPHB-mediated forward signaling 40 6.44e-01 -4.23e-02 8.31e-01
IRF3-mediated induction of type I IFN 12 8.01e-01 4.21e-02 9.15e-01
Receptor Mediated Mitophagy 11 8.09e-01 -4.21e-02 9.18e-01
Reproduction 86 5.03e-01 4.17e-02 7.45e-01
Formation of xylulose-5-phosphate 5 8.73e-01 4.14e-02 9.51e-01
Cell Cycle Checkpoints 246 2.70e-01 4.08e-02 5.54e-01
Synthesis of PG 8 8.42e-01 4.07e-02 9.35e-01
Regulation of KIT signaling 15 7.86e-01 4.05e-02 9.09e-01
Costimulation by the CD28 family 74 5.47e-01 4.05e-02 7.73e-01
RAC2 GTPase cycle 85 5.21e-01 -4.02e-02 7.61e-01
WNT ligand biogenesis and trafficking 20 7.57e-01 -4.00e-02 8.93e-01
FCERI mediated MAPK activation 94 5.03e-01 -4.00e-02 7.45e-01
Meiotic recombination 37 6.74e-01 -3.99e-02 8.53e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 6.83e-01 -3.99e-02 8.58e-01
SMAC (DIABLO) binds to IAPs 7 8.55e-01 -3.99e-02 9.39e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 8.55e-01 -3.99e-02 9.39e-01
SMAC, XIAP-regulated apoptotic response 7 8.55e-01 -3.99e-02 9.39e-01
Neddylation 216 3.13e-01 -3.98e-02 6.03e-01
FCGR3A-mediated phagocytosis 122 4.48e-01 -3.98e-02 7.14e-01
Leishmania phagocytosis 122 4.48e-01 -3.98e-02 7.14e-01
Parasite infection 122 4.48e-01 -3.98e-02 7.14e-01
Signaling by NOTCH2 33 6.96e-01 -3.93e-02 8.67e-01
Protein-protein interactions at synapses 58 6.05e-01 3.93e-02 8.09e-01
PLC beta mediated events 40 6.68e-01 -3.92e-02 8.48e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 7.30e-01 -3.92e-02 8.80e-01
Membrane binding and targetting of GAG proteins 13 8.07e-01 3.91e-02 9.18e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 8.07e-01 3.91e-02 9.18e-01
Cellular Senescence 143 4.25e-01 -3.87e-02 6.93e-01
Glucose metabolism 76 5.64e-01 3.83e-02 7.84e-01
Glycine degradation 7 8.61e-01 -3.82e-02 9.42e-01
Signaling by NTRK3 (TRKC) 15 7.99e-01 3.80e-02 9.15e-01
Diseases of glycosylation 110 4.92e-01 -3.79e-02 7.37e-01
Synthesis of PC 23 7.55e-01 -3.76e-02 8.91e-01
TGFBR3 PTM regulation 10 8.37e-01 -3.76e-02 9.33e-01
CHL1 interactions 8 8.54e-01 3.75e-02 9.39e-01
Base Excision Repair 57 6.27e-01 3.72e-02 8.19e-01
Synthesis of bile acids and bile salts 26 7.43e-01 -3.72e-02 8.87e-01
FCGR activation 77 5.73e-01 -3.71e-02 7.90e-01
Cardiac conduction 89 5.47e-01 -3.69e-02 7.73e-01
Activation of NOXA and translocation to mitochondria 5 8.86e-01 3.69e-02 9.56e-01
Signaling by WNT 240 3.27e-01 -3.67e-02 6.18e-01
Activation of NMDA receptors and postsynaptic events 74 5.87e-01 -3.66e-02 7.96e-01
Transcriptional regulation by small RNAs 61 6.23e-01 3.64e-02 8.16e-01
Golgi-to-ER retrograde transport 123 4.88e-01 -3.62e-02 7.36e-01
Aspirin ADME 15 8.09e-01 3.61e-02 9.18e-01
Regulation of NF-kappa B signaling 18 7.91e-01 -3.61e-02 9.13e-01
Bile acid and bile salt metabolism 30 7.32e-01 -3.61e-02 8.82e-01
XBP1(S) activates chaperone genes 44 6.80e-01 3.59e-02 8.58e-01
Death Receptor Signaling 145 4.57e-01 3.58e-02 7.17e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 7.49e-01 -3.56e-02 8.89e-01
Translesion synthesis by POLK 17 8.00e-01 3.56e-02 9.15e-01
TNFR1-induced NF-kappa-B signaling pathway 32 7.28e-01 -3.55e-02 8.80e-01
Phase 2 - plateau phase 11 8.39e-01 -3.53e-02 9.34e-01
Protein lipoylation 10 8.47e-01 3.53e-02 9.38e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 8.02e-01 3.52e-02 9.16e-01
Apoptotic cleavage of cellular proteins 35 7.19e-01 3.51e-02 8.75e-01
SARS-CoV-2-host interactions 182 4.15e-01 3.50e-02 6.85e-01
Toll Like Receptor 3 (TLR3) Cascade 104 5.42e-01 -3.46e-02 7.72e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 8.26e-01 3.39e-02 9.28e-01
SARS-CoV-1 Infection 137 4.95e-01 -3.38e-02 7.40e-01
Signaling by ERBB2 TMD/JMD mutants 17 8.11e-01 3.35e-02 9.18e-01
FGFR2 mutant receptor activation 23 7.81e-01 -3.35e-02 9.06e-01
Neuronal System 270 3.45e-01 -3.34e-02 6.35e-01
Cargo concentration in the ER 31 7.49e-01 -3.33e-02 8.89e-01
G beta:gamma signalling through BTK 15 8.23e-01 3.33e-02 9.27e-01
Recognition of DNA damage by PCNA-containing replication complex 30 7.53e-01 -3.32e-02 8.91e-01
p75NTR negatively regulates cell cycle via SC1 5 8.98e-01 3.32e-02 9.64e-01
SHC1 events in ERBB4 signaling 10 8.56e-01 3.32e-02 9.40e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 6.17e-01 -3.32e-02 8.14e-01
Asparagine N-linked glycosylation 286 3.35e-01 -3.31e-02 6.25e-01
Metabolism of RNA 717 1.35e-01 3.28e-02 3.74e-01
RHOD GTPase cycle 49 6.93e-01 3.26e-02 8.66e-01
Signaling by FGFR3 32 7.50e-01 3.25e-02 8.90e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 5.75e-01 -3.24e-02 7.90e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 6.74e-01 3.23e-02 8.53e-01
RNA Polymerase I Transcription Termination 30 7.61e-01 -3.21e-02 8.97e-01
Neurotransmitter release cycle 35 7.45e-01 3.17e-02 8.89e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 8.26e-01 -3.17e-02 9.28e-01
HIV Transcription Initiation 45 7.15e-01 -3.15e-02 8.72e-01
RNA Polymerase II HIV Promoter Escape 45 7.15e-01 -3.15e-02 8.72e-01
RNA Polymerase II Promoter Escape 45 7.15e-01 -3.15e-02 8.72e-01
RNA Polymerase II Transcription Initiation 45 7.15e-01 -3.15e-02 8.72e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 7.15e-01 -3.15e-02 8.72e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 7.15e-01 -3.15e-02 8.72e-01
Drug ADME 57 6.82e-01 -3.14e-02 8.58e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 8.24e-01 3.12e-02 9.27e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 8.24e-01 3.12e-02 9.27e-01
Voltage gated Potassium channels 27 7.80e-01 -3.11e-02 9.06e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 6.10e-01 -3.11e-02 8.14e-01
G-protein activation 19 8.14e-01 3.11e-02 9.20e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.65e-01 -3.11e-02 9.45e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 7.85e-01 -3.03e-02 9.09e-01
Translation of Structural Proteins 9694635 56 6.96e-01 -3.02e-02 8.67e-01
RNA Polymerase III Transcription Initiation 36 7.54e-01 3.02e-02 8.91e-01
Translesion synthesis by POLI 17 8.31e-01 -3.00e-02 9.29e-01
N-Glycan antennae elongation 13 8.53e-01 -2.98e-02 9.39e-01
Signaling by Nuclear Receptors 210 4.61e-01 2.95e-02 7.19e-01
Transmission across Chemical Synapses 183 4.92e-01 -2.95e-02 7.36e-01
Signaling by ERBB2 44 7.37e-01 -2.93e-02 8.84e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 8.55e-01 -2.93e-02 9.39e-01
Metabolism of vitamins and cofactors 167 5.15e-01 -2.92e-02 7.57e-01
RUNX3 regulates WNT signaling 8 8.87e-01 -2.90e-02 9.56e-01
Regulation of TP53 Activity through Methylation 19 8.27e-01 2.89e-02 9.28e-01
RHO GTPases activate KTN1 11 8.69e-01 2.87e-02 9.47e-01
Amine ligand-binding receptors 10 8.76e-01 2.85e-02 9.53e-01
Sensory processing of sound by outer hair cells of the cochlea 41 7.54e-01 -2.82e-02 8.91e-01
FOXO-mediated transcription of cell cycle genes 14 8.55e-01 -2.82e-02 9.39e-01
Synthesis of PA 31 7.87e-01 -2.81e-02 9.09e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 8.21e-01 2.79e-02 9.25e-01
MHC class II antigen presentation 113 6.09e-01 -2.79e-02 8.13e-01
Regulation of actin dynamics for phagocytic cup formation 124 5.95e-01 -2.76e-02 8.02e-01
Ub-specific processing proteases 153 5.57e-01 -2.75e-02 7.81e-01
SUMOylation of transcription factors 16 8.50e-01 2.73e-02 9.39e-01
Activation of caspases through apoptosome-mediated cleavage 6 9.08e-01 2.72e-02 9.64e-01
RHOC GTPase cycle 71 6.92e-01 2.72e-02 8.66e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 8.46e-01 2.72e-02 9.38e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.02e-01 2.69e-02 9.64e-01
IRE1alpha activates chaperones 46 7.53e-01 2.68e-02 8.91e-01
Fertilization 13 8.67e-01 -2.68e-02 9.46e-01
P2Y receptors 10 8.84e-01 2.66e-02 9.55e-01
O-linked glycosylation 85 6.73e-01 -2.65e-02 8.53e-01
Acetylcholine regulates insulin secretion 9 8.91e-01 2.64e-02 9.58e-01
RHOA GTPase cycle 138 5.93e-01 2.63e-02 8.00e-01
FOXO-mediated transcription 58 7.29e-01 -2.63e-02 8.80e-01
RHO GTPases activate CIT 18 8.47e-01 -2.62e-02 9.38e-01
FCGR3A-mediated IL10 synthesis 100 6.51e-01 -2.62e-02 8.35e-01
Diseases associated with O-glycosylation of proteins 50 7.49e-01 2.61e-02 8.89e-01
Metabolism of amine-derived hormones 10 8.87e-01 -2.60e-02 9.56e-01
IKK complex recruitment mediated by RIP1 23 8.31e-01 -2.58e-02 9.29e-01
Infectious disease 958 1.80e-01 -2.56e-02 4.50e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 6.33e-01 2.56e-02 8.23e-01
RHOU GTPase cycle 40 7.80e-01 -2.55e-02 9.06e-01
RUNX3 regulates CDKN1A transcription 7 9.08e-01 -2.53e-02 9.64e-01
O-glycosylation of TSR domain-containing proteins 28 8.18e-01 -2.51e-02 9.23e-01
G alpha (s) signalling events 96 6.74e-01 -2.48e-02 8.53e-01
rRNA modification in the mitochondrion 8 9.04e-01 -2.47e-02 9.64e-01
Activation of the phototransduction cascade 9 8.98e-01 2.46e-02 9.64e-01
Signaling by Non-Receptor Tyrosine Kinases 47 7.71e-01 2.46e-02 9.01e-01
Signaling by PTK6 47 7.71e-01 2.46e-02 9.01e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 8.58e-01 -2.44e-02 9.40e-01
RIPK1-mediated regulated necrosis 31 8.14e-01 -2.44e-02 9.20e-01
Regulation of necroptotic cell death 31 8.14e-01 -2.44e-02 9.20e-01
Cytosolic tRNA aminoacylation 24 8.36e-01 -2.44e-02 9.33e-01
G2/M Checkpoints 126 6.38e-01 -2.42e-02 8.27e-01
eNOS activation 11 8.90e-01 2.42e-02 9.57e-01
SLC-mediated transmembrane transport 174 5.87e-01 -2.39e-02 7.96e-01
COPII-mediated vesicle transport 67 7.36e-01 2.38e-02 8.84e-01
Cytosolic sensors of pathogen-associated DNA 63 7.44e-01 2.37e-02 8.88e-01
TNFR1-induced proapoptotic signaling 24 8.41e-01 2.37e-02 9.35e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 9.27e-01 -2.36e-02 9.74e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 8.29e-01 -2.36e-02 9.29e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 8.80e-01 -2.32e-02 9.53e-01
Interleukin-6 family signaling 20 8.57e-01 -2.32e-02 9.40e-01
HIV Infection 213 5.63e-01 2.30e-02 7.83e-01
Regulated Necrosis 56 7.68e-01 -2.28e-02 9.01e-01
HDACs deacetylate histones 45 7.93e-01 2.27e-02 9.13e-01
tRNA Aminoacylation 42 8.00e-01 2.26e-02 9.15e-01
TNF signaling 56 7.71e-01 -2.25e-02 9.01e-01
MyD88 dependent cascade initiated on endosome 101 6.97e-01 -2.24e-02 8.67e-01
CDC42 GTPase cycle 140 6.49e-01 2.23e-02 8.34e-01
RAC1 GTPase cycle 172 6.16e-01 2.21e-02 8.14e-01
Signaling by EGFR 47 7.93e-01 -2.21e-02 9.13e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 8.83e-01 2.19e-02 9.54e-01
Separation of Sister Chromatids 168 6.25e-01 -2.19e-02 8.17e-01
DNA Damage/Telomere Stress Induced Senescence 42 8.08e-01 2.17e-02 9.18e-01
HDL assembly 6 9.27e-01 -2.15e-02 9.74e-01
Glycosphingolipid transport 7 9.21e-01 -2.15e-02 9.73e-01
MyD88-independent TLR4 cascade 108 6.99e-01 -2.15e-02 8.67e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 6.99e-01 -2.15e-02 8.67e-01
Cell-Cell communication 110 6.98e-01 2.14e-02 8.67e-01
G alpha (q) signalling events 139 6.64e-01 -2.14e-02 8.44e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 7.08e-01 -2.12e-02 8.72e-01
Pre-NOTCH Expression and Processing 63 7.73e-01 -2.10e-02 9.03e-01
Sodium/Proton exchangers 7 9.24e-01 2.09e-02 9.74e-01
Defective B3GALTL causes PpS 27 8.52e-01 -2.08e-02 9.39e-01
Pyroptosis 25 8.58e-01 -2.07e-02 9.40e-01
Signaling by PDGF 48 8.05e-01 2.06e-02 9.17e-01
PECAM1 interactions 12 9.02e-01 2.06e-02 9.64e-01
RHOF GTPase cycle 38 8.26e-01 -2.06e-02 9.28e-01
HATs acetylate histones 92 7.33e-01 2.06e-02 8.82e-01
Nucleotide Excision Repair 108 7.18e-01 -2.01e-02 8.74e-01
Termination of O-glycan biosynthesis 16 8.90e-01 2.00e-02 9.57e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 9.06e-01 1.98e-02 9.64e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 8.78e-01 1.97e-02 9.53e-01
Acyl chain remodelling of PC 19 8.82e-01 -1.97e-02 9.53e-01
RMTs methylate histone arginines 35 8.41e-01 1.95e-02 9.35e-01
Role of phospholipids in phagocytosis 89 7.50e-01 1.95e-02 8.90e-01
Signaling by FGFR4 32 8.49e-01 1.95e-02 9.39e-01
SHC1 events in EGFR signaling 11 9.11e-01 1.94e-02 9.65e-01
Role of ABL in ROBO-SLIT signaling 6 9.34e-01 1.94e-02 9.75e-01
Signal Transduction 2051 1.53e-01 -1.91e-02 4.08e-01
Endosomal/Vacuolar pathway 12 9.09e-01 1.90e-02 9.65e-01
Extra-nuclear estrogen signaling 65 7.95e-01 -1.86e-02 9.15e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 8.00e-01 -1.86e-02 9.15e-01
Effects of PIP2 hydrolysis 24 8.78e-01 1.81e-02 9.53e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 7.88e-01 -1.81e-02 9.09e-01
Ion transport by P-type ATPases 44 8.39e-01 1.77e-02 9.34e-01
Protein ubiquitination 71 7.97e-01 -1.77e-02 9.15e-01
MAPK1 (ERK2) activation 9 9.27e-01 1.76e-02 9.74e-01
Calcitonin-like ligand receptors 5 9.46e-01 -1.76e-02 9.83e-01
SARS-CoV Infections 434 5.31e-01 1.75e-02 7.65e-01
Aflatoxin activation and detoxification 14 9.11e-01 -1.72e-02 9.65e-01
FLT3 Signaling 38 8.54e-01 -1.72e-02 9.39e-01
Vitamin B1 (thiamin) metabolism 5 9.48e-01 -1.69e-02 9.84e-01
Toll Like Receptor 9 (TLR9) Cascade 108 7.63e-01 1.68e-02 8.98e-01
Meiotic synapsis 43 8.49e-01 -1.68e-02 9.39e-01
Mitochondrial biogenesis 91 7.82e-01 1.68e-02 9.06e-01
MASTL Facilitates Mitotic Progression 10 9.27e-01 -1.67e-02 9.74e-01
Calcineurin activates NFAT 9 9.31e-01 1.67e-02 9.74e-01
S Phase 150 7.25e-01 -1.66e-02 8.80e-01
Uptake and actions of bacterial toxins 27 8.81e-01 -1.66e-02 9.53e-01
GRB2 events in EGFR signaling 10 9.28e-01 1.66e-02 9.74e-01
Nucleotide-like (purinergic) receptors 14 9.16e-01 -1.63e-02 9.68e-01
G beta:gamma signalling through PLC beta 17 9.08e-01 -1.62e-02 9.64e-01
Presynaptic function of Kainate receptors 17 9.08e-01 -1.62e-02 9.64e-01
GPVI-mediated activation cascade 32 8.77e-01 -1.59e-02 9.53e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 9.51e-01 1.59e-02 9.84e-01
Maple Syrup Urine Disease 5 9.51e-01 1.59e-02 9.84e-01
Translesion synthesis by REV1 16 9.14e-01 1.56e-02 9.67e-01
Synthesis of substrates in N-glycan biosythesis 59 8.36e-01 -1.56e-02 9.33e-01
Class I MHC mediated antigen processing & presentation 345 6.20e-01 -1.56e-02 8.16e-01
RHOB GTPase cycle 64 8.30e-01 1.55e-02 9.29e-01
DARPP-32 events 22 9.00e-01 -1.55e-02 9.64e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 8.84e-01 1.54e-02 9.55e-01
Synthesis of IP3 and IP4 in the cytosol 22 9.01e-01 1.53e-02 9.64e-01
Signaling by NOTCH1 66 8.30e-01 1.53e-02 9.29e-01
Estrogen-dependent gene expression 96 7.97e-01 -1.52e-02 9.15e-01
Potential therapeutics for SARS 150 7.48e-01 1.52e-02 8.89e-01
Metabolism of steroids 123 7.71e-01 -1.52e-02 9.01e-01
Cell junction organization 78 8.17e-01 1.51e-02 9.23e-01
SHC-mediated cascade:FGFR1 13 9.25e-01 -1.51e-02 9.74e-01
Unfolded Protein Response (UPR) 85 8.10e-01 -1.51e-02 9.18e-01
Adaptive Immune System 771 4.78e-01 -1.50e-02 7.29e-01
Estrogen-stimulated signaling through PRKCZ 6 9.50e-01 -1.48e-02 9.84e-01
Regulation of TP53 Degradation 35 8.80e-01 1.47e-02 9.53e-01
Sperm Motility And Taxes 6 9.50e-01 -1.47e-02 9.84e-01
Transcription of the HIV genome 67 8.36e-01 1.47e-02 9.33e-01
CLEC7A/inflammasome pathway 6 9.51e-01 1.45e-02 9.84e-01
Olfactory Signaling Pathway 57 8.51e-01 -1.44e-02 9.39e-01
Purine ribonucleoside monophosphate biosynthesis 9 9.41e-01 -1.42e-02 9.80e-01
Positive epigenetic regulation of rRNA expression 60 8.49e-01 -1.42e-02 9.39e-01
Glucuronidation 8 9.45e-01 -1.40e-02 9.83e-01
Insulin receptor signalling cascade 40 8.80e-01 1.38e-02 9.53e-01
ER to Golgi Anterograde Transport 145 7.75e-01 -1.37e-02 9.03e-01
RNA Polymerase III Abortive And Retractive Initiation 40 8.81e-01 1.37e-02 9.53e-01
RNA Polymerase III Transcription 40 8.81e-01 1.37e-02 9.53e-01
Golgi Associated Vesicle Biogenesis 55 8.61e-01 1.36e-02 9.42e-01
DAG and IP3 signaling 34 8.91e-01 1.35e-02 9.58e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 9.58e-01 1.35e-02 9.86e-01
Viral Infection Pathways 775 5.27e-01 -1.33e-02 7.61e-01
Phospholipid metabolism 183 7.59e-01 -1.32e-02 8.95e-01
Unwinding of DNA 12 9.38e-01 -1.30e-02 9.78e-01
Transcriptional Regulation by TP53 346 6.81e-01 1.28e-02 8.58e-01
Regulation of PTEN gene transcription 59 8.65e-01 -1.28e-02 9.45e-01
RHO GTPase cycle 411 6.57e-01 1.28e-02 8.40e-01
CaM pathway 28 9.07e-01 -1.27e-02 9.64e-01
Calmodulin induced events 28 9.07e-01 -1.27e-02 9.64e-01
Regulation of TP53 Expression and Degradation 36 8.95e-01 -1.27e-02 9.62e-01
AKT phosphorylates targets in the nucleus 10 9.45e-01 1.25e-02 9.83e-01
Vesicle-mediated transport 665 5.83e-01 -1.25e-02 7.94e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.24e-01 -1.24e-02 9.74e-01
SARS-CoV-2 Infection 267 7.28e-01 1.24e-02 8.80e-01
Ketone body metabolism 8 9.52e-01 -1.23e-02 9.84e-01
Class B/2 (Secretin family receptors) 57 8.74e-01 1.22e-02 9.51e-01
ADP signalling through P2Y purinoceptor 12 18 9.30e-01 1.20e-02 9.74e-01
ESR-mediated signaling 157 7.97e-01 -1.19e-02 9.15e-01
RND3 GTPase cycle 35 9.04e-01 1.18e-02 9.64e-01
Transport to the Golgi and subsequent modification 171 7.92e-01 -1.17e-02 9.13e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 9.04e-01 1.16e-02 9.64e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.55e-01 -1.14e-02 9.85e-01
CD28 co-stimulation 33 9.11e-01 1.13e-02 9.65e-01
Gamma-carboxylation of protein precursors 6 9.62e-01 1.12e-02 9.87e-01
Diseases of Base Excision Repair 5 9.66e-01 -1.12e-02 9.88e-01
Cytochrome P450 - arranged by substrate type 39 9.05e-01 -1.11e-02 9.64e-01
Phosphorylation of the APC/C 20 9.32e-01 1.11e-02 9.74e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.32e-01 -1.10e-02 9.74e-01
Mitochondrial tRNA aminoacylation 21 9.31e-01 1.10e-02 9.74e-01
HCMV Late Events 67 8.78e-01 1.09e-02 9.53e-01
HCMV Infection 106 8.47e-01 1.08e-02 9.38e-01
Host Interactions of HIV factors 118 8.40e-01 1.08e-02 9.34e-01
Signaling by ERBB4 45 9.02e-01 -1.07e-02 9.64e-01
p75 NTR receptor-mediated signalling 89 8.62e-01 1.06e-02 9.43e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 9.66e-01 1.00e-02 9.88e-01
Thromboxane signalling through TP receptor 20 9.38e-01 -1.00e-02 9.78e-01
PI3K events in ERBB2 signaling 11 9.55e-01 9.79e-03 9.85e-01
Metabolism of water-soluble vitamins and cofactors 116 8.59e-01 9.54e-03 9.41e-01
Disease 1623 5.43e-01 -9.06e-03 7.72e-01
Toll-like Receptor Cascades 162 8.46e-01 -8.87e-03 9.38e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 623 7.06e-01 -8.84e-03 8.71e-01
Signaling by Hippo 18 9.51e-01 -8.39e-03 9.84e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 9.53e-01 -8.06e-03 9.84e-01
Metal ion SLC transporters 19 9.53e-01 -7.87e-03 9.84e-01
Apoptotic cleavage of cell adhesion proteins 8 9.69e-01 7.83e-03 9.90e-01
Prolactin receptor signaling 11 9.64e-01 7.83e-03 9.88e-01
RHOG GTPase cycle 70 9.11e-01 7.69e-03 9.65e-01
Formation of RNA Pol II elongation complex 56 9.27e-01 7.08e-03 9.74e-01
RNA Polymerase II Transcription Elongation 56 9.27e-01 7.08e-03 9.74e-01
Regulation of CDH19 Expression and Function 6 9.76e-01 7.04e-03 9.93e-01
Kidney development 17 9.60e-01 -6.96e-03 9.87e-01
Sensory Perception 194 8.68e-01 6.90e-03 9.47e-01
Transcriptional regulation of pluripotent stem cells 19 9.61e-01 6.48e-03 9.87e-01
FCERI mediated Ca+2 mobilization 93 9.15e-01 -6.40e-03 9.68e-01
Factors involved in megakaryocyte development and platelet production 129 9.01e-01 -6.34e-03 9.64e-01
Regulation of insulin secretion 63 9.31e-01 -6.27e-03 9.74e-01
Diseases of signal transduction by growth factor receptors and second messengers 401 8.32e-01 6.19e-03 9.30e-01
RET signaling 32 9.52e-01 -6.11e-03 9.84e-01
Telomere Maintenance 78 9.26e-01 6.09e-03 9.74e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 9.59e-01 6.09e-03 9.86e-01
RAB GEFs exchange GTP for GDP on RABs 88 9.22e-01 -6.07e-03 9.73e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 9.59e-01 5.97e-03 9.86e-01
Glycosphingolipid biosynthesis 15 9.69e-01 -5.72e-03 9.90e-01
Mitotic Metaphase and Anaphase 212 8.89e-01 5.54e-03 9.57e-01
MAPK3 (ERK1) activation 10 9.76e-01 5.53e-03 9.93e-01
Cytokine Signaling in Immune system 668 8.08e-01 5.53e-03 9.18e-01
Mitotic G2-G2/M phases 179 8.99e-01 -5.48e-03 9.64e-01
Processing of Capped Intronless Pre-mRNA 29 9.60e-01 -5.35e-03 9.87e-01
Defects in biotin (Btn) metabolism 8 9.80e-01 -5.24e-03 9.93e-01
Specification of primordial germ cells 6 9.84e-01 -4.82e-03 9.93e-01
Rap1 signalling 14 9.76e-01 -4.72e-03 9.93e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.70e-01 -4.69e-03 9.90e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.70e-01 -4.69e-03 9.90e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 9.84e-01 -4.48e-03 9.93e-01
G-protein mediated events 44 9.61e-01 -4.28e-03 9.87e-01
Prostacyclin signalling through prostacyclin receptor 16 9.77e-01 -4.24e-03 9.93e-01
Downregulation of TGF-beta receptor signaling 26 9.70e-01 -4.23e-03 9.90e-01
Signaling by Rho GTPases 607 8.59e-01 -4.22e-03 9.41e-01
Fcgamma receptor (FCGR) dependent phagocytosis 148 9.30e-01 -4.21e-03 9.74e-01
TBC/RABGAPs 45 9.63e-01 4.04e-03 9.87e-01
Disorders of transmembrane transporters 136 9.35e-01 -4.03e-03 9.76e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 37 9.66e-01 4.01e-03 9.88e-01
NFE2L2 regulating MDR associated enzymes 8 9.84e-01 3.98e-03 9.93e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 9.72e-01 3.95e-03 9.91e-01
Rab regulation of trafficking 121 9.42e-01 -3.83e-03 9.81e-01
Attachment of GPI anchor to uPAR 7 9.86e-01 -3.80e-03 9.93e-01
Regulation of FZD by ubiquitination 16 9.80e-01 -3.59e-03 9.93e-01
Opioid Signalling 75 9.57e-01 3.58e-03 9.86e-01
Mitotic Anaphase 211 9.29e-01 3.56e-03 9.74e-01
Diseases associated with glycosaminoglycan metabolism 26 9.77e-01 3.28e-03 9.93e-01
SUMOylation of intracellular receptors 26 9.78e-01 -3.11e-03 9.93e-01
Assembly Of The HIV Virion 15 9.83e-01 3.09e-03 9.93e-01
Maturation of hRSV A proteins 13 9.85e-01 -3.04e-03 9.93e-01
PI3K/AKT Signaling in Cancer 84 9.62e-01 3.00e-03 9.87e-01
EPHA-mediated growth cone collapse 21 9.81e-01 2.98e-03 9.93e-01
Uptake and function of anthrax toxins 11 9.86e-01 2.97e-03 9.93e-01
Calnexin/calreticulin cycle 26 9.80e-01 -2.77e-03 9.93e-01
Nuclear signaling by ERBB4 24 9.83e-01 -2.56e-03 9.93e-01
Apoptotic execution phase 46 9.77e-01 -2.51e-03 9.93e-01
Endogenous sterols 17 9.86e-01 2.47e-03 9.93e-01
WNT mediated activation of DVL 8 9.90e-01 -2.46e-03 9.95e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 9.56e-01 2.33e-03 9.85e-01
Deubiquitination 225 9.54e-01 -2.23e-03 9.85e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 9.90e-01 2.17e-03 9.95e-01
Membrane Trafficking 574 9.33e-01 -2.07e-03 9.74e-01
Post-translational protein modification 1245 9.05e-01 2.01e-03 9.64e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 9.94e-01 2.00e-03 9.97e-01
Diseases associated with the TLR signaling cascade 29 9.85e-01 2.00e-03 9.93e-01
Diseases of Immune System 29 9.85e-01 2.00e-03 9.93e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 9.86e-01 1.75e-03 9.93e-01
FOXO-mediated transcription of cell death genes 16 9.91e-01 -1.70e-03 9.95e-01
Signaling by LTK 10 9.94e-01 1.43e-03 9.97e-01
Toxicity of botulinum toxin type D (botD) 5 9.96e-01 1.38e-03 9.98e-01
Toxicity of botulinum toxin type F (botF) 5 9.96e-01 1.38e-03 9.98e-01
Ovarian tumor domain proteases 37 9.89e-01 1.26e-03 9.95e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 9.79e-01 9.09e-04 9.93e-01
Expression and translocation of olfactory receptors 52 9.93e-01 -6.93e-04 9.97e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 9.99e-01 -4.48e-04 9.99e-01
EPH-ephrin mediated repulsion of cells 43 9.97e-01 2.99e-04 9.99e-01
Triglyceride biosynthesis 9 9.99e-01 -1.47e-04 9.99e-01
G2/M Transition 177 9.98e-01 9.71e-05 9.99e-01


Detailed Gene set reports



Biosynthesis of EPA-derived SPMs
set Biosynthesis of EPA-derived SPMs
setSize 6
pANOVA 0.000257
s.dist -0.862
p.adjustANOVA 0.00439


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 -10673
HPGD -10510
PTGS2 -10481
ALOX15 -9878
LTA4H -8079
GPX4 -5552

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 -10673
HPGD -10510
PTGS2 -10481
ALOX15 -9878
LTA4H -8079
GPX4 -5552


Biosynthesis of Lipoxins (LX)
set Biosynthesis of Lipoxins (LX)
setSize 6
pANOVA 0.000334
s.dist -0.846
p.adjustANOVA 0.00525


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 -10673
HPGD -10510
ALOX5AP -9682
PTGR1 -8103
ALOX12 -8085
LTC4S -7073

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 -10673
HPGD -10510
ALOX5AP -9682
PTGR1 -8103
ALOX12 -8085
LTC4S -7073


Biosynthesis of E-series 18(S)-resolvins
set Biosynthesis of E-series 18(S)-resolvins
setSize 5
pANOVA 0.00117
s.dist -0.838
p.adjustANOVA 0.0135


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 -10673
HPGD -10510
ALOX15 -9878
LTA4H -8079
GPX4 -5552

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 -10673
HPGD -10510
ALOX15 -9878
LTA4H -8079
GPX4 -5552


Protein repair
set Protein repair
setSize 6
pANOVA 0.000925
s.dist -0.781
p.adjustANOVA 0.0115


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSRB2 -9933
MSRA -9084
PCMT1 -8984
MSRB1 -8275
TXN -7801
MSRB3 -5800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSRB2 -9933
MSRA -9084
PCMT1 -8984
MSRB1 -8275
TXN -7801
MSRB3 -5800


Cross-presentation of particulate exogenous antigens (phagosomes)
set Cross-presentation of particulate exogenous antigens (phagosomes)
setSize 8
pANOVA 0.000206
s.dist -0.758
p.adjustANOVA 0.00364


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCF1 -10360
NCF4 -10214
CD36 -9365
ITGB5 -8400
ITGAV -7840
CYBB -7005
CYBA -5970
NCF2 -5331

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCF1 -10360
NCF4 -10214
CD36 -9365
ITGB5 -8400
ITGAV -7840
CYBB -7005
CYBA -5970
NCF2 -5331


Synthesis of 15-eicosatetraenoic acid derivatives
set Synthesis of 15-eicosatetraenoic acid derivatives
setSize 6
pANOVA 0.00271
s.dist -0.707
p.adjustANOVA 0.0241


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTGS2 -10481
GPX1 -10479
ALOX15B -10350
ALOX15 -9878
GPX4 -5552
GPX2 1710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGS2 -10481
GPX1 -10479
ALOX15B -10350
ALOX15 -9878
GPX4 -5552
GPX2 1710


MECP2 regulates transcription of neuronal ligands
set MECP2 regulates transcription of neuronal ligands
setSize 5
pANOVA 0.00704
s.dist 0.696
p.adjustANOVA 0.0524


Top enriched genes
Top 20 genes
GeneID Gene Rank
SIN3A 10542
CREB1 9851
MECP2 9075
DLL1 6641
HDAC1 3046

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SIN3A 10542
CREB1 9851
MECP2 9075
DLL1 6641
HDAC1 3046


Synthesis of 5-eicosatetraenoic acids
set Synthesis of 5-eicosatetraenoic acids
setSize 7
pANOVA 0.00155
s.dist -0.691
p.adjustANOVA 0.0165


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 -10673
GPX1 -10479
ALOX5AP -9682
PON2 -9564
LTC4S -7073
GPX4 -5552
GPX2 1710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 -10673
GPX1 -10479
ALOX5AP -9682
PON2 -9564
LTC4S -7073
GPX4 -5552
GPX2 1710


Fructose catabolism
set Fructose catabolism
setSize 5
pANOVA 0.0104
s.dist -0.662
p.adjustANOVA 0.0669


Top enriched genes
Top 20 genes
GeneID Gene Rank
GLYCTK -8820
TKFC -8787
ALDH1A1 -8574
KHK -5881
ALDOB -2987

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GLYCTK -8820
TKFC -8787
ALDH1A1 -8574
KHK -5881
ALDOB -2987


Synthesis of 12-eicosatetraenoic acid derivatives
set Synthesis of 12-eicosatetraenoic acid derivatives
setSize 6
pANOVA 0.00506
s.dist -0.661
p.adjustANOVA 0.04


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX1 -10479
ALOX15 -9878
ALOX12B -9722
ALOX12 -8085
GPX4 -5552
GPX2 1710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX1 -10479
ALOX15 -9878
ALOX12B -9722
ALOX12 -8085
GPX4 -5552
GPX2 1710


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.00127
s.dist 0.658
p.adjustANOVA 0.0141


Top enriched genes
Top 20 genes
GeneID Gene Rank
POLB 10305
ADPRS 9755
FEN1 9574
PARP1 8375
LIG1 7286
PARP2 7053
PARG 6247
APEX1 733

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLB 10305
ADPRS 9755
FEN1 9574
PARP1 8375
LIG1 7286
PARP2 7053
PARG 6247
APEX1 733


Signal attenuation
set Signal attenuation
setSize 9
pANOVA 0.000686
s.dist -0.653
p.adjustANOVA 0.00906


Top enriched genes
Top 20 genes
GeneID Gene Rank
INSR -10599
IRS1 -10590
GRB10 -10508
IRS2 -10342
MAPK1 -8540
MAPK3 -8523
SOS1 -2160
GRB2 -1766
SHC1 746

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INSR -10599
IRS1 -10590
GRB10 -10508
IRS2 -10342
MAPK1 -8540
MAPK3 -8523
SOS1 -2160
GRB2 -1766
SHC1 746


Interleukin-21 signaling
set Interleukin-21 signaling
setSize 9
pANOVA 0.00117
s.dist 0.625
p.adjustANOVA 0.0135


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAT4 9748
IL21R 9403
JAK1 9056
STAT5A 8514
STAT1 7770
STAT5B 6322
STAT3 6072
IL2RG 4155
JAK3 2411

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT4 9748
IL21R 9403
JAK1 9056
STAT5A 8514
STAT1 7770
STAT5B 6322
STAT3 6072
IL2RG 4155
JAK3 2411


OAS antiviral response
set OAS antiviral response
setSize 8
pANOVA 0.00257
s.dist 0.616
p.adjustANOVA 0.0231


Top enriched genes
Top 20 genes
GeneID Gene Rank
OAS2 10999
OAS3 10944
OASL 10748
OAS1 9580
PDE12 6948
RNASEL 4094
ABCE1 3597
FLNA -1304

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OAS2 10999
OAS3 10944
OASL 10748
OAS1 9580
PDE12 6948
RNASEL 4094
ABCE1 3597
FLNA -1304


Acetylcholine binding and downstream events
set Acetylcholine binding and downstream events
setSize 5
pANOVA 0.0186
s.dist 0.608
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHRNA2 9830
CHRNB2 9596
CHRNE 7901
CHRNA5 6911
CHRNA7 83

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHRNA2 9830
CHRNB2 9596
CHRNE 7901
CHRNA5 6911
CHRNA7 83


Postsynaptic nicotinic acetylcholine receptors
set Postsynaptic nicotinic acetylcholine receptors
setSize 5
pANOVA 0.0186
s.dist 0.608
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
CHRNA2 9830
CHRNB2 9596
CHRNE 7901
CHRNA5 6911
CHRNA7 83

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHRNA2 9830
CHRNB2 9596
CHRNE 7901
CHRNA5 6911
CHRNA7 83


Defective LFNG causes SCDO3
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0267
s.dist 0.572
p.adjustANOVA 0.129


Top enriched genes
Top 20 genes
GeneID Gene Rank
LFNG 8539
NOTCH3 8271
NOTCH1 7154
NOTCH2 5317
NOTCH4 3114

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LFNG 8539
NOTCH3 8271
NOTCH1 7154
NOTCH2 5317
NOTCH4 3114


Histidine catabolism
set Histidine catabolism
setSize 7
pANOVA 0.00889
s.dist -0.571
p.adjustANOVA 0.0612


Top enriched genes
Top 20 genes
GeneID Gene Rank
HDC -9826
HAL -8825
AMDHD1 -8797
FTCD -6873
CARNS1 -6399
HNMT -3245
CARNMT1 1828

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HDC -9826
HAL -8825
AMDHD1 -8797
FTCD -6873
CARNS1 -6399
HNMT -3245
CARNMT1 1828


NFE2L2 regulating inflammation associated genes
set NFE2L2 regulating inflammation associated genes
setSize 5
pANOVA 0.0271
s.dist 0.571
p.adjustANOVA 0.131


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCL2 10471
NFE2L2 10401
EP300 9616
CREBBP 5194
MAFK -3379

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL2 10471
NFE2L2 10401
EP300 9616
CREBBP 5194
MAFK -3379


Keratan sulfate degradation
set Keratan sulfate degradation
setSize 9
pANOVA 0.00319
s.dist -0.568
p.adjustANOVA 0.0275


Top enriched genes
Top 20 genes
GeneID Gene Rank
HEXA -10544
GALNS -9822
GLB1L -9783
GNS -9767
GLB1L2 -8727
GLB1 -7231
HEXB -5899
PRELP 3073
GLB1L3 4869

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HEXA -10544
GALNS -9822
GLB1L -9783
GNS -9767
GLB1L2 -8727
GLB1 -7231
HEXB -5899
PRELP 3073
GLB1L3 4869


Formyl peptide receptors bind formyl peptides and many other ligands
set Formyl peptide receptors bind formyl peptides and many other ligands
setSize 7
pANOVA 0.0102
s.dist -0.561
p.adjustANOVA 0.066


Top enriched genes
Top 20 genes
GeneID Gene Rank
APP -9660
FPR1 -9487
ANXA1 -8784
FPR2 -7032
HEBP1 -6919
MT-RNR2 -4181
FPR3 4717

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APP -9660
FPR1 -9487
ANXA1 -8784
FPR2 -7032
HEBP1 -6919
MT-RNR2 -4181
FPR3 4717


Loss of MECP2 binding ability to the NCoR/SMRT complex
set Loss of MECP2 binding ability to the NCoR/SMRT complex
setSize 7
pANOVA 0.0107
s.dist 0.557
p.adjustANOVA 0.0677


Top enriched genes
Top 20 genes
GeneID Gene Rank
TBL1XR1 9207
MECP2 9075
NCOR1 8304
GPS2 5875
HDAC3 5581
TBL1X 4528
NCOR2 1628

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TBL1XR1 9207
MECP2 9075
NCOR1 8304
GPS2 5875
HDAC3 5581
TBL1X 4528
NCOR2 1628


Antimicrobial peptides
set Antimicrobial peptides
setSize 34
pANOVA 1.86e-08
s.dist -0.557
p.adjustANOVA 1.43e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
S100A9 -10671
S100A8 -10617
TLR2 -10546
PRTN3 -10442
DEFA4 -10436
PDZD11 -10383
BPI -10328
LCN2 -10319
DEFA1 -10309
PGLYRP1 -10287
ELANE -10154
DEFA3 -10130
LTF -10051
CAMP -10047
CTSG -9989
RNASE3 -9782
ATOX1 -9629
CLU -9185
PGLYRP2 -8904
PI3 -8456

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 -10671
S100A8 -10617
TLR2 -10546
PRTN3 -10442
DEFA4 -10436
PDZD11 -10383
BPI -10328
LCN2 -10319
DEFA1 -10309
PGLYRP1 -10287
ELANE -10154
DEFA3 -10130
LTF -10051
CAMP -10047
CTSG -9989
RNASE3 -9782
ATOX1 -9629
CLU -9185
PGLYRP2 -8904
PI3 -8456
SLC11A1 -7182
PGLYRP3 -7012
RNASE6 -5829
HTN1 -4557
GNLY -3145
EPPIN -1391
LYZ -1378
CCR2 -565
CCR6 2195
TLR1 3977
ITLN1 4866
CD4 5158
ATP7A 8022
LEAP2 8242


Replacement of protamines by nucleosomes in the male pronucleus
set Replacement of protamines by nucleosomes in the male pronucleus
setSize 13
pANOVA 0.000531
s.dist -0.555
p.adjustANOVA 0.00746


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC12 -10667
NPM2 -10648
H2BC11 -10012
H2BC9 -9583
METTL23 -9421
H2BC5 -8896
H2BC21 -8892
H2BC17 -7381
H3-3A -5383
H2BC15 -4626
SRPK1 902
H2BC4 1118
HIRA 7543

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC12 -10667
NPM2 -10648
H2BC11 -10012
H2BC9 -9583
METTL23 -9421
H2BC5 -8896
H2BC21 -8892
H2BC17 -7381
H3-3A -5383
H2BC15 -4626
SRPK1 902
H2BC4 1118
HIRA 7543


Diseases of Mismatch Repair (MMR)
set Diseases of Mismatch Repair (MMR)
setSize 5
pANOVA 0.0322
s.dist 0.553
p.adjustANOVA 0.148


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH6 9052
MLH1 8371
PMS2 7609
MSH2 7269
MSH3 -952

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH6 9052
MLH1 8371
PMS2 7609
MSH2 7269
MSH3 -952


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0335
s.dist -0.549
p.adjustANOVA 0.152


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 -9337
ETHE1 -8855
TST -8549
SUOX -5600
TSTD1 3439

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 -9337
ETHE1 -8855
TST -8549
SUOX -5600
TSTD1 3439


Cohesin Loading onto Chromatin
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 0.00266
s.dist 0.549
p.adjustANOVA 0.0238


Top enriched genes
Top 20 genes
GeneID Gene Rank
NIPBL 10708
STAG1 9865
STAG2 9393
SMC3 9277
SMC1A 7187
RAD21 5912
PDS5B 4566
WAPL 4279
MAU2 2909
PDS5A -1898

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NIPBL 10708
STAG1 9865
STAG2 9393
SMC3 9277
SMC1A 7187
RAD21 5912
PDS5B 4566
WAPL 4279
MAU2 2909
PDS5A -1898


RNA Polymerase I Promoter Opening
set RNA Polymerase I Promoter Opening
setSize 17
pANOVA 9.24e-05
s.dist -0.548
p.adjustANOVA 0.00228


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2BC12 -10667.0
H3C15 -10035.5
H2BC11 -10012.0
H2BC9 -9583.0
H2BC5 -8896.0
H2BC21 -8892.0
MBD2 -8619.0
MAPK3 -8523.0
H2AC6 -7406.0
H2BC17 -7381.0
H2AJ -6447.0
H3-3A -5383.0
H2BC15 -4626.0
H2AC20 -1389.0
H2BC4 1118.0
H2AZ2 2371.0
UBTF 6431.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2BC12 -10667.0
H3C15 -10035.5
H2BC11 -10012.0
H2BC9 -9583.0
H2BC5 -8896.0
H2BC21 -8892.0
MBD2 -8619.0
MAPK3 -8523.0
H2AC6 -7406.0
H2BC17 -7381.0
H2AJ -6447.0
H3-3A -5383.0
H2BC15 -4626.0
H2AC20 -1389.0
H2BC4 1118.0
H2AZ2 2371.0
UBTF 6431.0


Metabolism of Angiotensinogen to Angiotensins
set Metabolism of Angiotensinogen to Angiotensins
setSize 12
pANOVA 0.00107
s.dist -0.545
p.adjustANOVA 0.0127


Top enriched genes
Top 20 genes
GeneID Gene Rank
ANPEP -10277
CTSG -9989
MME -9111
CTSD -9004
ACE -7516
CPA3 -7414
GZMH -7173
AGT -6152
CTSZ -4476
ACE2 -3224
ATP6AP2 -1242
CES1 6720

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANPEP -10277
CTSG -9989
MME -9111
CTSD -9004
ACE -7516
CPA3 -7414
GZMH -7173
AGT -6152
CTSZ -4476
ACE2 -3224
ATP6AP2 -1242
CES1 6720


Mitotic Telophase/Cytokinesis
set Mitotic Telophase/Cytokinesis
setSize 13
pANOVA 0.000916
s.dist 0.531
p.adjustANOVA 0.0115


Top enriched genes
Top 20 genes
GeneID Gene Rank
NIPBL 10708
STAG1 9865
STAG2 9393
SMC3 9277
KIF23 8835
SMC1A 7187
RAD21 5912
PDS5B 4566
WAPL 4279
PLK1 3993
KIF20A 3300
MAU2 2909
PDS5A -1898

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NIPBL 10708
STAG1 9865
STAG2 9393
SMC3 9277
KIF23 8835
SMC1A 7187
RAD21 5912
PDS5B 4566
WAPL 4279
PLK1 3993
KIF20A 3300
MAU2 2909
PDS5A -1898


mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
set mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
setSize 6
pANOVA 0.025
s.dist -0.528
p.adjustANOVA 0.123


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACADL -9706
HADHB -7206
DECR1 -7023
HADHA -5293
ECI1 -4788
ACADM 690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACADL -9706
HADHB -7206
DECR1 -7023
HADHA -5293
ECI1 -4788
ACADM 690


Fibronectin matrix formation
set Fibronectin matrix formation
setSize 6
pANOVA 0.0266
s.dist -0.523
p.adjustANOVA 0.129


Top enriched genes
Top 20 genes
GeneID Gene Rank
CEACAM6 -10252
ITGB1 -9923
CEACAM8 -9885
CEACAM1 -5412
FN1 -4060
ITGA5 6575

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CEACAM6 -10252
ITGB1 -9923
CEACAM8 -9885
CEACAM1 -5412
FN1 -4060
ITGA5 6575


Response of EIF2AK1 (HRI) to heme deficiency
set Response of EIF2AK1 (HRI) to heme deficiency
setSize 14
pANOVA 0.00071
s.dist -0.523
p.adjustANOVA 0.0093


Top enriched genes
Top 20 genes
GeneID Gene Rank
GRB10 -10508
PPP1R15A -9942
ATF3 -9604
EIF2AK1 -9318
CEBPG -8775
CEBPB -6892
TRIB3 -6840
ATF4 -6827
EIF2S3 -4942
DDIT3 -4767
EIF2S1 -3894
EIF2S2 -2417
ASNS 1219
ATF5 6672

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB10 -10508
PPP1R15A -9942
ATF3 -9604
EIF2AK1 -9318
CEBPG -8775
CEBPB -6892
TRIB3 -6840
ATF4 -6827
EIF2S3 -4942
DDIT3 -4767
EIF2S1 -3894
EIF2S2 -2417
ASNS 1219
ATF5 6672


Axonal growth inhibition (RHOA activation)
set Axonal growth inhibition (RHOA activation)
setSize 7
pANOVA 0.0176
s.dist -0.518
p.adjustANOVA 0.0983


Top enriched genes
Top 20 genes
GeneID Gene Rank
NGFR -10612
OMG -10120
RHOA -7623
RTN4 -4984
ARHGDIA -2640
MCF2 -1733
RTN4R -362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NGFR -10612
OMG -10120
RHOA -7623
RTN4 -4984
ARHGDIA -2640
MCF2 -1733
RTN4R -362


p75NTR regulates axonogenesis
set p75NTR regulates axonogenesis
setSize 7
pANOVA 0.0176
s.dist -0.518
p.adjustANOVA 0.0983


Top enriched genes
Top 20 genes
GeneID Gene Rank
NGFR -10612
OMG -10120
RHOA -7623
RTN4 -4984
ARHGDIA -2640
MCF2 -1733
RTN4R -362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NGFR -10612
OMG -10120
RHOA -7623
RTN4 -4984
ARHGDIA -2640
MCF2 -1733
RTN4R -362


Prostanoid ligand receptors
set Prostanoid ligand receptors
setSize 8
pANOVA 0.0115
s.dist -0.516
p.adjustANOVA 0.0707


Top enriched genes
Top 20 genes
GeneID Gene Rank
PTGER2 -10709
PTGFR -8509
PTGDR2 -8302
PTGER4 -6949
TBXA2R -6900
PTGER3 -3619
PTGDR -3241
PTGIR 4899

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGER2 -10709
PTGFR -8509
PTGDR2 -8302
PTGER4 -6949
TBXA2R -6900
PTGER3 -3619
PTGDR -3241
PTGIR 4899


DEx/H-box helicases activate type I IFN and inflammatory cytokines production
set DEx/H-box helicases activate type I IFN and inflammatory cytokines production
setSize 7
pANOVA 0.0181
s.dist 0.516
p.adjustANOVA 0.1


Top enriched genes
Top 20 genes
GeneID Gene Rank
IRF7 10871
NFKB1 9436
RELA 8244
NFKB2 7462
DHX36 5068
DHX9 4705
MYD88 -4760

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRF7 10871
NFKB1 9436
RELA 8244
NFKB2 7462
DHX36 5068
DHX9 4705
MYD88 -4760


NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
set NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
setSize 32
pANOVA 5.19e-07
s.dist 0.513
p.adjustANOVA 2.97e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABCA1 11154
ABCG8 11072
ABCG1 10987
KDM3A 10942
TNRC6A 10539
APOE 10212
EP300 9616
TNRC6B 9337
TBL1XR1 9207
NR1H3 9106
TNRC6C 8757
NCOR1 8304
NCOA1 8284
AGO3 8114
MOV10 7685
RXRA 7111
KDM4A 6946
EEPD1 6907
GPS2 5875
HDAC3 5581

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCA1 11154
ABCG8 11072
ABCG1 10987
KDM3A 10942
TNRC6A 10539
APOE 10212
EP300 9616
TNRC6B 9337
TBL1XR1 9207
NR1H3 9106
TNRC6C 8757
NCOR1 8304
NCOA1 8284
AGO3 8114
MOV10 7685
RXRA 7111
KDM4A 6946
EEPD1 6907
GPS2 5875
HDAC3 5581
TBL1X 4528
AGO2 4346
RXRB 4276
AGO1 3382
KDM1B 1896
NCOR2 1628
PLTP 877
ARL4C 776
KDM1A 27
CETP -485
NR1H2 -3855
AGO4 -6933


HDL remodeling
set HDL remodeling
setSize 6
pANOVA 0.0301
s.dist 0.511
p.adjustANOVA 0.141


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABCG1 10987
LIPG 10820
APOE 10212
LCAT 2464
PLTP 877
CETP -485

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCG1 10987
LIPG 10820
APOE 10212
LCAT 2464
PLTP 877
CETP -485


HDR through MMEJ (alt-NHEJ)
set HDR through MMEJ (alt-NHEJ)
setSize 12
pANOVA 0.00245
s.dist 0.505
p.adjustANOVA 0.0223


Top enriched genes
Top 20 genes
GeneID Gene Rank
BRCA2 10426
FEN1 9574
MRE11 8792
PARP1 8375
LIG3 7818
RAD50 7471
PARP2 7053
POLQ 5787
RBBP8 2913
NBN 791
RAD52 680
XRCC1 -787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRCA2 10426
FEN1 9574
MRE11 8792
PARP1 8375
LIG3 7818
RAD50 7471
PARP2 7053
POLQ 5787
RBBP8 2913
NBN 791
RAD52 680
XRCC1 -787


Induction of Cell-Cell Fusion
set Induction of Cell-Cell Fusion
setSize 8
pANOVA 0.0137
s.dist -0.503
p.adjustANOVA 0.081


Top enriched genes
Top 20 genes
GeneID Gene Rank
ANO5 -9935
ANO7 -8833
ANO6 -8711
ANO10 -7490
ANO8 -4732
ACE2 -3224
FURIN -857
ANO9 1557

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANO5 -9935
ANO7 -8833
ANO6 -8711
ANO10 -7490
ANO8 -4732
ACE2 -3224
FURIN -857
ANO9 1557


TGFBR3 expression
set TGFBR3 expression
setSize 20
pANOVA 0.000103
s.dist 0.502
p.adjustANOVA 0.00248


Top enriched genes
Top 20 genes
GeneID Gene Rank
TCF4 10832
SMAD4 10688
TNRC6A 10539
EP300 9616
TNRC6B 9337
TNRC6C 8757
TGFBR3 8733
AGO3 8114
RARA 8021
SP1 7731
MOV10 7685
RXRA 7111
TCF3 5180
KLF16 4430
AGO2 4346
TCF12 4004
AGO1 3382
SMAD3 -447
AGO4 -6933
HELLS -7092

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCF4 10832
SMAD4 10688
TNRC6A 10539
EP300 9616
TNRC6B 9337
TNRC6C 8757
TGFBR3 8733
AGO3 8114
RARA 8021
SP1 7731
MOV10 7685
RXRA 7111
TCF3 5180
KLF16 4430
AGO2 4346
TCF12 4004
AGO1 3382
SMAD3 -447
AGO4 -6933
HELLS -7092


Common Pathway of Fibrin Clot Formation
set Common Pathway of Fibrin Clot Formation
setSize 13
pANOVA 0.00177
s.dist -0.501
p.adjustANOVA 0.0182


Top enriched genes
Top 20 genes
GeneID Gene Rank
PROCR -10629
PRTN3 -10442
F13A1 -10232
PF4 -10044
CD177 -8343
F2R -7491
SERPINE2 -6980
F5 -6277
PROS1 -5785
THBD -2126
F8 -760
PF4V1 99
PROC 10769

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROCR -10629
PRTN3 -10442
F13A1 -10232
PF4 -10044
CD177 -8343
F2R -7491
SERPINE2 -6980
F5 -6277
PROS1 -5785
THBD -2126
F8 -760
PF4V1 99
PROC 10769


Linoleic acid (LA) metabolism
set Linoleic acid (LA) metabolism
setSize 7
pANOVA 0.0223
s.dist -0.499
p.adjustANOVA 0.114


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACSL1 -10550
FADS1 -8454
FADS2 -8306
ELOVL1 -7338
ELOVL3 -2887
ABCD1 -879
ELOVL5 1814

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSL1 -10550
FADS1 -8454
FADS2 -8306
ELOVL1 -7338
ELOVL3 -2887
ABCD1 -879
ELOVL5 1814


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.0225
s.dist -0.498
p.adjustANOVA 0.115


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLR2 -10546
UBA52 -8146
UBB -6124
RPS27A -4977
UBC -3577
B2M -2786
MRC1 -385

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 -10546
UBA52 -8146
UBB -6124
RPS27A -4977
UBC -3577
B2M -2786
MRC1 -385


Regulation of CDH11 mRNA translation by microRNAs
set Regulation of CDH11 mRNA translation by microRNAs
setSize 8
pANOVA 0.015
s.dist 0.497
p.adjustANOVA 0.0875


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6A 10539
TNRC6B 9337
TNRC6C 8757
AGO3 8114
MOV10 7685
AGO2 4346
AGO1 3382
AGO4 -6933

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6A 10539
TNRC6B 9337
TNRC6C 8757
AGO3 8114
MOV10 7685
AGO2 4346
AGO1 3382
AGO4 -6933


Regulation of NPAS4 mRNA translation
set Regulation of NPAS4 mRNA translation
setSize 8
pANOVA 0.015
s.dist 0.497
p.adjustANOVA 0.0875


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6A 10539
TNRC6B 9337
TNRC6C 8757
AGO3 8114
MOV10 7685
AGO2 4346
AGO1 3382
AGO4 -6933

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6A 10539
TNRC6B 9337
TNRC6C 8757
AGO3 8114
MOV10 7685
AGO2 4346
AGO1 3382
AGO4 -6933


Relaxin receptors
set Relaxin receptors
setSize 5
pANOVA 0.0547
s.dist -0.496
p.adjustANOVA 0.211


Top enriched genes
Top 20 genes
GeneID Gene Rank
RLN3 -10027
INSL3 -9037
RXFP4 -8768
RXFP2 -1914
RLN2 3739

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RLN3 -10027
INSL3 -9037
RXFP4 -8768
RXFP2 -1914
RLN2 3739


Phosphate bond hydrolysis by NTPDase proteins
set Phosphate bond hydrolysis by NTPDase proteins
setSize 5
pANOVA 0.0572
s.dist 0.491
p.adjustANOVA 0.218


Top enriched genes
Top 20 genes
GeneID Gene Rank
ENTPD7 9887
ENTPD5 9190
ENTPD6 5471
ENTPD4 5304
ENTPD1 -1897

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ENTPD7 9887
ENTPD5 9190
ENTPD6 5471
ENTPD4 5304
ENTPD1 -1897


Regulation of NPAS4 gene expression
set Regulation of NPAS4 gene expression
setSize 11
pANOVA 0.00512
s.dist 0.487
p.adjustANOVA 0.0403


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6A 10539
NR3C1 9396
TNRC6B 9337
TNRC6C 8757
AGO3 8114
MOV10 7685
SRF 6173
AGO2 4346
AGO1 3382
REST 248
AGO4 -6933

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNRC6A 10539
NR3C1 9396
TNRC6B 9337
TNRC6C 8757
AGO3 8114
MOV10 7685
SRF 6173
AGO2 4346
AGO1 3382
REST 248
AGO4 -6933


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report