Mitch Report

date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-1.9378570
A1BG	-1.0557397
A1BG-AS1	-0.1955978
A1CF	0.6818832
A2M	0.4955888
A2M-AS1	0.8142046

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2725
num_genes_in_profile	21999
duplicated_genes_present	0
num_profile_genes_in_sets	8829
num_profile_genes_not_in_sets	13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1188
num_genesets_included	1537

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Arachidonate production from DAG	5	1.55e-03	-0.817	1.08e-02
Formation of ATP by chemiosmotic coupling	20	2.93e-10	-0.814	8.83e-09
MET activates PI3K/AKT signaling	5	2.63e-03	0.777	1.69e-02
PI3K events in ERBB4 signaling	6	1.53e-03	0.747	1.07e-02
Malate-aspartate shuttle	8	4.35e-04	-0.718	3.68e-03
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	2.36e-03	-0.717	1.54e-02
Synthesis of Ketone Bodies	6	2.77e-03	-0.705	1.76e-02
Purine ribonucleoside monophosphate biosynthesis	9	3.05e-04	-0.695	2.67e-03
Maturation of spike protein 9683686	5	7.16e-03	-0.694	3.85e-02
Ketone body metabolism	8	7.27e-04	-0.690	5.78e-03
Mitochondrial translation elongation	90	1.03e-29	-0.689	1.53e-27
Peptide chain elongation	88	1.76e-28	-0.682	1.70e-26
Mitochondrial translation initiation	90	9.60e-29	-0.677	1.03e-26
Viral mRNA Translation	88	1.72e-27	-0.669	1.45e-25
Cristae formation	33	3.62e-11	-0.665	1.13e-09
Eukaryotic Translation Elongation	93	1.40e-28	-0.664	1.42e-26
Complex III assembly	23	3.92e-08	-0.662	9.46e-07
Mitochondrial translation termination	90	2.15e-27	-0.660	1.73e-25
Eukaryotic Translation Termination	92	1.09e-27	-0.657	1.00e-25
SRP-dependent cotranslational protein targeting to membrane	111	7.62e-33	-0.655	1.64e-30
Formation of a pool of free 40S subunits	100	1.88e-29	-0.651	2.14e-27
Selenocysteine synthesis	92	4.54e-27	-0.649	3.37e-25
SARS-CoV-1 modulates host translation machinery	36	1.70e-11	-0.648	5.46e-10
Synthesis of GDP-mannose	6	6.02e-03	-0.648	3.30e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	3.18e-27	-0.644	2.45e-25
Mitochondrial translation	96	1.63e-27	-0.641	1.44e-25
Mitochondrial protein import	63	1.71e-18	-0.639	8.24e-17
Nucleotide biosynthesis	12	1.58e-04	-0.630	1.49e-03
L13a-mediated translational silencing of Ceruloplasmin expression	110	1.15e-29	-0.623	1.59e-27
Release of apoptotic factors from the mitochondria	6	8.48e-03	-0.621	4.42e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.25e-29	-0.620	1.59e-27
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	7.88e-27	-0.620	5.64e-25
Cohesin Loading onto Chromatin	10	7.31e-04	0.617	5.79e-03
Cap-dependent Translation Initiation	118	8.08e-31	-0.614	1.42e-28
Eukaryotic Translation Initiation	118	8.08e-31	-0.614	1.42e-28
Translation	293	1.36e-70	-0.601	2.63e-67
SARS-CoV-2 modulates host translation machinery	49	5.28e-13	-0.596	1.93e-11
rRNA processing in the nucleus and cytosol	189	6.04e-45	-0.592	3.89e-42
Mitochondrial tRNA aminoacylation	21	2.66e-06	-0.592	3.99e-05
Major pathway of rRNA processing in the nucleolus and cytosol	179	1.69e-42	-0.591	8.17e-40
rRNA processing	213	1.07e-49	-0.588	1.03e-46
Formation of xylulose-5-phosphate	5	2.54e-02	-0.577	1.02e-01
Classical antibody-mediated complement activation	69	1.19e-16	-0.576	5.47e-15
Formation of the ternary complex, and subsequently, the 43S complex	51	1.11e-12	-0.576	3.89e-11
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.03e-03	-0.571	7.87e-03
Folding of actin by CCT/TriC	10	2.03e-03	-0.564	1.37e-02
Ribosomal scanning and start codon recognition	58	1.50e-13	-0.560	5.92e-12
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	3.01e-02	-0.560	1.16e-01
Cytosolic iron-sulfur cluster assembly	13	4.72e-04	-0.560	3.99e-03
Selenoamino acid metabolism	115	3.38e-25	-0.559	2.25e-23

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Arachidonate production from DAG	5	1.55e-03	-0.817000	1.08e-02
Formation of ATP by chemiosmotic coupling	20	2.93e-10	-0.814000	8.83e-09
MET activates PI3K/AKT signaling	5	2.63e-03	0.777000	1.69e-02
PI3K events in ERBB4 signaling	6	1.53e-03	0.747000	1.07e-02
Malate-aspartate shuttle	8	4.35e-04	-0.718000	3.68e-03
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	2.36e-03	-0.717000	1.54e-02
Synthesis of Ketone Bodies	6	2.77e-03	-0.705000	1.76e-02
Purine ribonucleoside monophosphate biosynthesis	9	3.05e-04	-0.695000	2.67e-03
Maturation of spike protein 9683686	5	7.16e-03	-0.694000	3.85e-02
Ketone body metabolism	8	7.27e-04	-0.690000	5.78e-03
Mitochondrial translation elongation	90	1.03e-29	-0.689000	1.53e-27
Peptide chain elongation	88	1.76e-28	-0.682000	1.70e-26
Mitochondrial translation initiation	90	9.60e-29	-0.677000	1.03e-26
Viral mRNA Translation	88	1.72e-27	-0.669000	1.45e-25
Cristae formation	33	3.62e-11	-0.665000	1.13e-09
Eukaryotic Translation Elongation	93	1.40e-28	-0.664000	1.42e-26
Complex III assembly	23	3.92e-08	-0.662000	9.46e-07
Mitochondrial translation termination	90	2.15e-27	-0.660000	1.73e-25
Eukaryotic Translation Termination	92	1.09e-27	-0.657000	1.00e-25
SRP-dependent cotranslational protein targeting to membrane	111	7.62e-33	-0.655000	1.64e-30
Formation of a pool of free 40S subunits	100	1.88e-29	-0.651000	2.14e-27
Selenocysteine synthesis	92	4.54e-27	-0.649000	3.37e-25
SARS-CoV-1 modulates host translation machinery	36	1.70e-11	-0.648000	5.46e-10
Synthesis of GDP-mannose	6	6.02e-03	-0.648000	3.30e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	3.18e-27	-0.644000	2.45e-25
Mitochondrial translation	96	1.63e-27	-0.641000	1.44e-25
Mitochondrial protein import	63	1.71e-18	-0.639000	8.24e-17
Nucleotide biosynthesis	12	1.58e-04	-0.630000	1.49e-03
L13a-mediated translational silencing of Ceruloplasmin expression	110	1.15e-29	-0.623000	1.59e-27
Release of apoptotic factors from the mitochondria	6	8.48e-03	-0.621000	4.42e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.25e-29	-0.620000	1.59e-27
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	7.88e-27	-0.620000	5.64e-25
Cohesin Loading onto Chromatin	10	7.31e-04	0.617000	5.79e-03
Cap-dependent Translation Initiation	118	8.08e-31	-0.614000	1.42e-28
Eukaryotic Translation Initiation	118	8.08e-31	-0.614000	1.42e-28
Translation	293	1.36e-70	-0.601000	2.63e-67
SARS-CoV-2 modulates host translation machinery	49	5.28e-13	-0.596000	1.93e-11
rRNA processing in the nucleus and cytosol	189	6.04e-45	-0.592000	3.89e-42
Mitochondrial tRNA aminoacylation	21	2.66e-06	-0.592000	3.99e-05
Major pathway of rRNA processing in the nucleolus and cytosol	179	1.69e-42	-0.591000	8.17e-40
rRNA processing	213	1.07e-49	-0.588000	1.03e-46
Formation of xylulose-5-phosphate	5	2.54e-02	-0.577000	1.02e-01
Classical antibody-mediated complement activation	69	1.19e-16	-0.576000	5.47e-15
Formation of the ternary complex, and subsequently, the 43S complex	51	1.11e-12	-0.576000	3.89e-11
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.03e-03	-0.571000	7.87e-03
Folding of actin by CCT/TriC	10	2.03e-03	-0.564000	1.37e-02
Ribosomal scanning and start codon recognition	58	1.50e-13	-0.560000	5.92e-12
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	3.01e-02	-0.560000	1.16e-01
Cytosolic iron-sulfur cluster assembly	13	4.72e-04	-0.560000	3.99e-03
Selenoamino acid metabolism	115	3.38e-25	-0.559000	2.25e-23
rRNA modification in the nucleus and cytosol	59	1.13e-13	-0.559000	4.53e-12
RUNX1 regulates transcription of genes involved in BCR signaling	6	1.83e-02	0.556000	8.03e-02
Abacavir ADME	5	3.15e-02	0.555000	1.21e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.70e-13	-0.554000	6.58e-12
Translation initiation complex formation	58	3.72e-13	-0.551000	1.38e-11
tRNA processing in the mitochondrion	24	3.03e-06	-0.550000	4.46e-05
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.57e-03	0.550000	1.09e-02
Creation of C4 and C2 activators	71	1.54e-15	-0.547000	6.90e-14
rRNA processing in the mitochondrion	24	3.92e-06	-0.544000	5.41e-05
SLBP independent Processing of Histone Pre-mRNAs	10	3.05e-03	-0.541000	1.93e-02
Scavenging of heme from plasma	70	4.89e-15	-0.541000	2.05e-13
Defective GALNT12 causes CRCS1	9	5.12e-03	-0.539000	2.90e-02
Respiratory electron transport	149	6.48e-30	-0.538000	1.04e-27
Phosphate bond hydrolysis by NUDT proteins	7	1.36e-02	-0.538000	6.47e-02
rRNA modification in the mitochondrion	8	8.55e-03	-0.537000	4.44e-02
Regulation of expression of SLITs and ROBOs	149	1.32e-29	-0.536000	1.59e-27
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	2.12e-03	0.535000	1.42e-02
CD22 mediated BCR regulation	58	1.79e-12	-0.535000	6.19e-11
Specification of primordial germ cells	6	2.34e-02	0.534000	9.64e-02
Sulfide oxidation to sulfate	5	3.91e-02	-0.533000	1.41e-01
PI-3K cascade:FGFR3	10	3.71e-03	0.530000	2.22e-02
Metabolism of folate and pterines	16	2.46e-04	-0.529000	2.23e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.72e-22	-0.528000	9.49e-21
Nonsense-Mediated Decay (NMD)	114	1.72e-22	-0.528000	9.49e-21
Maturation of TCA enzymes and regulation of TCA cycle	20	4.33e-05	-0.528000	4.84e-04
PTK6 Regulates Cell Cycle	6	2.57e-02	-0.526000	1.03e-01
GDP-fucose biosynthesis	6	2.61e-02	-0.524000	1.03e-01
tRNA Aminoacylation	42	4.28e-09	-0.524000	1.25e-07
FGFR3 ligand binding and activation	5	4.31e-02	0.522000	1.49e-01
FGFR3c ligand binding and activation	5	4.31e-02	0.522000	1.49e-01
Organic anion transporters	7	1.72e-02	-0.520000	7.78e-02
Initial triggering of complement	79	1.58e-15	-0.518000	6.94e-14
ARMS-mediated activation	6	2.82e-02	0.517000	1.09e-01
Mitochondrial iron-sulfur cluster biogenesis	13	1.25e-03	-0.517000	9.10e-03
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	9.67e-05	-0.517000	9.94e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	2.58e-08	-0.515000	6.40e-07
p53-Independent DNA Damage Response	39	2.58e-08	-0.515000	6.40e-07
p53-Independent G1/S DNA damage checkpoint	39	2.58e-08	-0.515000	6.40e-07
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	4.63e-02	-0.515000	1.56e-01
Influenza Viral RNA Transcription and Replication	135	7.99e-25	-0.512000	5.14e-23
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	1.83e-08	-0.508000	4.78e-07
Vif-mediated degradation of APOBEC3G	41	1.99e-08	-0.506000	5.12e-07
Post-transcriptional silencing by small RNAs	7	2.04e-02	0.506000	8.76e-02
MECP2 regulates transcription factors	5	5.09e-02	0.504000	1.67e-01
Regulation of ornithine decarboxylase (ODC)	38	1.10e-07	-0.498000	2.47e-06
Mitochondrial calcium ion transport	22	5.44e-05	-0.497000	6.00e-04
Complex I biogenesis	66	3.59e-12	-0.495000	1.22e-10
Metabolism of polyamines	46	6.90e-09	-0.494000	1.93e-07
Citric acid cycle (TCA cycle)	34	6.88e-07	-0.492000	1.24e-05
Complex IV assembly	45	1.13e-08	-0.492000	3.11e-07
Synthesis of 12-eicosatetraenoic acid derivatives	6	4.01e-02	-0.484000	1.42e-01
Autodegradation of the E3 ubiquitin ligase COP1	38	2.68e-07	-0.482000	5.59e-06
PI3K events in ERBB2 signaling	11	5.73e-03	0.481000	3.19e-02
Ubiquitin-dependent degradation of Cyclin D	39	2.46e-07	-0.477000	5.22e-06
Synthesis of 15-eicosatetraenoic acid derivatives	6	4.36e-02	-0.476000	1.50e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	3.11e-03	-0.474000	1.95e-02
Influenza Infection	154	3.44e-24	-0.473000	2.14e-22
Cytosolic tRNA aminoacylation	24	6.12e-05	-0.473000	6.64e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	6.74e-07	-0.472000	1.23e-05
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	4.53e-02	-0.472000	1.54e-01
Cleavage of the damaged purine	22	1.49e-04	-0.467000	1.43e-03
Depurination	22	1.49e-04	-0.467000	1.43e-03
Recognition and association of DNA glycosylase with site containing an affected purine	22	1.49e-04	-0.467000	1.43e-03
Vpu mediated degradation of CD4	39	4.51e-07	-0.467000	8.63e-06
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	7.11e-02	-0.466000	2.09e-01
Aerobic respiration and respiratory electron transport	245	2.90e-36	-0.466000	6.99e-34
Activated NTRK3 signals through PI3K	5	7.22e-02	0.464000	2.12e-01
Cellular response to starvation	148	2.32e-22	-0.463000	1.25e-20
Defective HLCS causes multiple carboxylase deficiency	7	3.43e-02	-0.462000	1.29e-01
SCF-beta-TrCP mediated degradation of Emi1	42	2.23e-07	-0.462000	4.83e-06
Formation of tubulin folding intermediates by CCT/TriC	21	2.50e-04	-0.462000	2.26e-03
DNA Damage Reversal	8	2.47e-02	-0.458000	1.00e-01
Modulation by Mtb of host immune system	7	3.58e-02	-0.458000	1.32e-01
Hh mutants are degraded by ERAD	42	2.86e-07	-0.458000	5.82e-06
Phenylalanine and tyrosine metabolism	9	1.76e-02	-0.457000	7.88e-02
Cross-presentation of soluble exogenous antigens (endosomes)	35	3.18e-06	-0.455000	4.63e-05
KSRP (KHSRP) binds and destabilizes mRNA	17	1.17e-03	-0.455000	8.65e-03
APOBEC3G mediated resistance to HIV-1 infection	5	7.86e-02	-0.454000	2.23e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	1.30e-02	-0.454000	6.27e-02
Hh mutants abrogate ligand secretion	43	2.72e-07	-0.453000	5.59e-06
Mitochondrial RNA degradation	25	8.86e-05	-0.453000	9.20e-04
Recycling of eIF2:GDP	8	2.71e-02	-0.451000	1.06e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	8.13e-02	-0.450000	2.28e-01
FGFR2c ligand binding and activation	5	8.18e-02	0.449000	2.29e-01
Proteasome assembly	50	4.19e-08	-0.448000	9.99e-07
Negative regulation of NOTCH4 signaling	44	2.71e-07	-0.448000	5.59e-06
Defective CFTR causes cystic fibrosis	47	1.12e-07	-0.447000	2.49e-06
Alternative complement activation	5	8.33e-02	-0.447000	2.33e-01
Killing mechanisms	9	2.06e-02	-0.446000	8.78e-02
WNT5:FZD7-mediated leishmania damping	9	2.06e-02	-0.446000	8.78e-02
FCGR activation	76	2.00e-11	-0.445000	6.35e-10
Molybdenum cofactor biosynthesis	6	5.93e-02	-0.445000	1.84e-01
tRNA modification in the mitochondrion	9	2.13e-02	-0.443000	8.95e-02
Prefoldin mediated transfer of substrate to CCT/TriC	25	1.29e-04	-0.442000	1.29e-03
Mitochondrial protein degradation	96	7.34e-14	-0.442000	3.02e-12
DNA methylation	18	1.20e-03	-0.441000	8.80e-03
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	8.82e-02	0.440000	2.42e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	8.13e-07	-0.440000	1.45e-05
The role of GTSE1 in G2/M progression after G2 checkpoint	59	5.13e-09	-0.440000	1.48e-07
Synthesis of Dolichyl-phosphate	6	6.24e-02	-0.439000	1.91e-01
Glycosphingolipid transport	7	4.48e-02	-0.438000	1.53e-01
RUNX2 regulates genes involved in cell migration	6	6.37e-02	-0.437000	1.92e-01
Fatty acids	6	6.39e-02	0.437000	1.92e-01
Synthesis of diphthamide-EEF2	8	3.27e-02	-0.436000	1.24e-01
Activation of RAS in B cells	5	9.17e-02	0.435000	2.48e-01
Hedgehog ligand biogenesis	47	2.43e-07	-0.435000	5.22e-06
Abortive elongation of HIV-1 transcript in the absence of Tat	23	3.06e-04	-0.435000	2.67e-03
Phenylalanine metabolism	5	9.31e-02	-0.434000	2.50e-01
Diseases of Base Excision Repair	5	9.42e-02	-0.432000	2.53e-01
Degradation of DVL	43	9.63e-07	-0.432000	1.66e-05
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	7.69e-05	-0.432000	8.12e-04
Interleukin-6 signaling	11	1.35e-02	0.430000	6.46e-02
Packaging Of Telomere Ends	18	1.64e-03	-0.429000	1.13e-02
Binding and Uptake of Ligands by Scavenger Receptors	94	7.46e-13	-0.428000	2.67e-11
IFNG signaling activates MAPKs	8	3.63e-02	0.427000	1.34e-01
Gain-of-function MRAS complexes activate RAF signaling	8	3.65e-02	0.427000	1.34e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	3.65e-02	0.427000	1.34e-01
Signaling by MRAS-complex mutants	8	3.65e-02	0.427000	1.34e-01
Gamma-carboxylation of protein precursors	6	7.06e-02	-0.426000	2.08e-01
RNA Polymerase III Chain Elongation	18	1.76e-03	-0.426000	1.20e-02
Reversal of alkylation damage by DNA dioxygenases	7	5.13e-02	-0.425000	1.68e-01
Defective GALNT3 causes HFTC	9	2.73e-02	-0.425000	1.07e-01
PI-3K cascade:FGFR4	11	1.47e-02	0.425000	6.83e-02
Signaling by FGFR3 in disease	14	5.94e-03	0.425000	3.28e-02
Regulation of PTEN mRNA translation	13	8.13e-03	0.424000	4.29e-02
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	1.01e-01	0.423000	2.64e-01
Regulation of Apoptosis	40	3.64e-06	-0.423000	5.17e-05
Regulation of CDH11 mRNA translation by microRNAs	8	3.85e-02	0.423000	1.40e-01
Regulation of NPAS4 mRNA translation	8	3.85e-02	0.423000	1.40e-01
TNFR1-mediated ceramide production	6	7.34e-02	-0.422000	2.14e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	2.25e-06	-0.422000	3.48e-05
Signaling by LTK in cancer	7	5.51e-02	0.419000	1.75e-01
NADE modulates death signalling	5	1.06e-01	-0.418000	2.72e-01
Acyl chain remodelling of PI	10	2.24e-02	0.417000	9.31e-02
Asymmetric localization of PCP proteins	49	4.45e-07	-0.417000	8.59e-06
Post-chaperonin tubulin folding pathway	18	2.26e-03	-0.416000	1.48e-02
NFE2L2 regulates pentose phosphate pathway genes	8	4.30e-02	0.413000	1.49e-01
Interleukin-18 signaling	6	8.13e-02	0.411000	2.28e-01
Calcitonin-like ligand receptors	5	1.12e-01	0.410000	2.85e-01
Protein localization	157	6.47e-19	-0.410000	3.20e-17
SCF(Skp2)-mediated degradation of p27/p21	50	5.13e-07	-0.410000	9.46e-06
Formation of axial mesoderm	6	8.18e-02	0.410000	2.29e-01
Gluconeogenesis	19	2.02e-03	-0.409000	1.37e-02
ATF6 (ATF6-alpha) activates chaperones	12	1.43e-02	-0.408000	6.69e-02
Regulation of RUNX3 expression and activity	45	2.15e-06	-0.408000	3.36e-05
Role of LAT2/NTAL/LAB on calcium mobilization	77	6.08e-10	-0.408000	1.81e-08
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	6.20e-02	-0.407000	1.90e-01
Stabilization of p53	43	3.81e-06	-0.407000	5.34e-05
Regulation of Complement cascade	96	5.25e-12	-0.407000	1.75e-10
RNA Polymerase I Promoter Opening	17	3.65e-03	-0.407000	2.21e-02
Germ layer formation at gastrulation	9	3.47e-02	0.407000	1.29e-01
MET activates RAP1 and RAC1	10	2.69e-02	0.404000	1.06e-01
Defective C1GALT1C1 causes TNPS	10	2.75e-02	-0.403000	1.07e-01
HDMs demethylate histones	22	1.09e-03	0.402000	8.09e-03
Signaling by ROBO receptors	189	1.50e-21	-0.402000	7.84e-20
Somitogenesis	41	9.34e-06	-0.400000	1.21e-04
Diseases associated with glycosylation precursor biosynthesis	15	7.44e-03	-0.399000	3.97e-02
Prostanoid ligand receptors	8	5.15e-02	-0.398000	1.68e-01
Pausing and recovery of Tat-mediated HIV elongation	30	1.65e-04	-0.397000	1.54e-03
Tat-mediated HIV elongation arrest and recovery	30	1.65e-04	-0.397000	1.54e-03
Degradation of GLI2 by the proteasome	45	4.47e-06	-0.395000	6.04e-05
Signaling by FLT3 fusion proteins	18	3.70e-03	0.395000	2.22e-02
Diseases associated with N-glycosylation of proteins	20	2.24e-03	-0.395000	1.48e-02
Reversible hydration of carbon dioxide	8	5.32e-02	0.395000	1.71e-01
Complement cascade	100	9.73e-12	-0.394000	3.19e-10
Phase 3 - rapid repolarisation	6	9.57e-02	0.393000	2.56e-01
APC/C:Cdc20 mediated degradation of Securin	55	4.78e-07	-0.392000	9.06e-06
Phosphorylation of Emi1	6	9.73e-02	-0.391000	2.58e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	1.30e-01	0.391000	3.13e-01
Ubiquinol biosynthesis	13	1.51e-02	-0.389000	6.98e-02
Termination of O-glycan biosynthesis	16	7.28e-03	-0.387000	3.91e-02
Sema4D mediated inhibition of cell attachment and migration	7	7.60e-02	-0.387000	2.19e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	1.36e-01	0.385000	3.20e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	4.17e-04	-0.385000	3.58e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	5.30e-04	-0.385000	4.34e-03
Signaling by cytosolic FGFR1 fusion mutants	18	5.02e-03	0.382000	2.86e-02
Digestion	5	1.40e-01	0.382000	3.24e-01
Na+/Cl- dependent neurotransmitter transporters	8	6.26e-02	0.380000	1.91e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	2.93e-07	-0.380000	5.89e-06
Mitotic Telophase/Cytokinesis	13	1.79e-02	0.379000	7.99e-02
GLI3 is processed to GLI3R by the proteasome	46	8.99e-06	-0.378000	1.18e-04
Purine catabolism	16	8.85e-03	-0.378000	4.56e-02
Defects in biotin (Btn) metabolism	8	6.43e-02	-0.378000	1.93e-01
Autodegradation of Cdh1 by Cdh1:APC/C	54	1.84e-06	-0.375000	2.97e-05
SUMO is conjugated to E1 (UBA2:SAE1)	5	1.46e-01	-0.375000	3.35e-01
PTK6 promotes HIF1A stabilization	6	1.12e-01	0.374000	2.85e-01
Regulation of RUNX2 expression and activity	54	2.05e-06	-0.373000	3.22e-05
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.20e-02	-0.373000	1.22e-01
Erythropoietin activates Phospholipase C gamma (PLCG)	6	1.14e-01	0.372000	2.88e-01
Degradation of cysteine and homocysteine	13	2.02e-02	-0.372000	8.69e-02
Base-Excision Repair, AP Site Formation	29	5.32e-04	-0.372000	4.34e-03
Protein hydroxylation	17	8.19e-03	-0.370000	4.31e-02
FCERI mediated NF-kB activation	129	3.68e-13	-0.370000	1.38e-11
Processing of SMDT1	15	1.31e-02	-0.370000	6.33e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	3.95e-06	-0.370000	5.41e-05
DNA Damage Recognition in GG-NER	38	8.23e-05	-0.369000	8.64e-04
Orc1 removal from chromatin	58	1.17e-06	-0.369000	1.95e-05
Degradation of AXIN	42	3.76e-05	-0.367000	4.25e-04
G1/S DNA Damage Checkpoints	54	3.02e-06	-0.367000	4.46e-05
Inhibition of DNA recombination at telomere	33	2.85e-04	-0.365000	2.52e-03
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	6	1.23e-01	0.364000	3.05e-01
CD209 (DC-SIGN) signaling	20	4.91e-03	0.363000	2.80e-02
Degradation of GLI1 by the proteasome	46	2.03e-05	-0.363000	2.37e-04
Defective pyroptosis	27	1.09e-03	-0.363000	8.11e-03
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	2.94e-02	-0.363000	1.14e-01
Activation of the phototransduction cascade	8	7.60e-02	0.362000	2.19e-01
NOTCH2 intracellular domain regulates transcription	11	3.75e-02	0.362000	1.37e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	1.25e-01	-0.362000	3.07e-01
HIV elongation arrest and recovery	32	4.33e-04	-0.359000	3.68e-03
Pausing and recovery of HIV elongation	32	4.33e-04	-0.359000	3.68e-03
Synthesis of glycosylphosphatidylinositol (GPI)	18	8.67e-03	-0.357000	4.49e-02
TGFBR3 expression	20	5.74e-03	0.357000	3.19e-02
SIRT1 negatively regulates rRNA expression	22	3.87e-03	-0.356000	2.30e-02
Biotin transport and metabolism	11	4.13e-02	-0.355000	1.44e-01
Miscellaneous substrates	7	1.06e-01	0.353000	2.73e-01
Metabolism of amino acids and derivatives	308	1.98e-26	-0.352000	1.37e-24
Apoptotic factor-mediated response	19	7.95e-03	-0.352000	4.22e-02
Methionine salvage pathway	6	1.36e-01	-0.351000	3.20e-01
Cellular hexose transport	14	2.29e-02	-0.351000	9.49e-02
p53-Dependent G1 DNA Damage Response	52	1.24e-05	-0.350000	1.53e-04
p53-Dependent G1/S DNA damage checkpoint	52	1.24e-05	-0.350000	1.53e-04
Regulation of IFNG signaling	14	2.36e-02	0.349000	9.72e-02
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	1.35e-05	-0.349000	1.62e-04
Ribavirin ADME	11	4.57e-02	-0.348000	1.55e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	1.52e-06	-0.347000	2.49e-05
Sulfur amino acid metabolism	23	4.11e-03	-0.346000	2.41e-02
CDK-mediated phosphorylation and removal of Cdc6	60	3.76e-06	-0.345000	5.31e-05
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	3.85e-06	-0.345000	5.35e-05
PDH complex synthesizes acetyl-CoA from PYR	5	1.83e-01	-0.344000	3.77e-01
Displacement of DNA glycosylase by APEX1	9	7.42e-02	-0.344000	2.16e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	5.29e-03	-0.343000	2.97e-02
RUNX1 regulates estrogen receptor mediated transcription	6	1.45e-01	0.343000	3.35e-01
SHC1 events in ERBB4 signaling	10	6.02e-02	0.343000	1.86e-01
Glutamate and glutamine metabolism	12	3.96e-02	-0.343000	1.41e-01
Regulation of APC/C activators between G1/S and early anaphase	68	1.04e-06	-0.342000	1.79e-05
FGFR2 alternative splicing	25	3.11e-03	-0.342000	1.95e-02
Cleavage of the damaged pyrimidine	27	2.20e-03	-0.340000	1.46e-02
Depyrimidination	27	2.20e-03	-0.340000	1.46e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	2.20e-03	-0.340000	1.46e-02
Xenobiotics	12	4.12e-02	0.340000	1.44e-01
NIK–>noncanonical NF-kB signaling	46	7.06e-05	-0.339000	7.55e-04
RNA Polymerase I Promoter Escape	45	8.61e-05	-0.338000	8.99e-04
Reactions specific to the complex N-glycan synthesis pathway	7	1.21e-01	-0.338000	3.02e-01
PCP/CE pathway	75	4.12e-07	-0.338000	8.03e-06
APC/C:Cdc20 mediated degradation of mitotic proteins	63	3.46e-06	-0.338000	4.98e-05
tRNA processing	128	4.14e-11	-0.338000	1.27e-09
Activation of RAC1 downstream of NMDARs	7	1.22e-01	-0.337000	3.04e-01
GAB1 signalosome	15	2.38e-02	0.337000	9.75e-02
Signaling by FGFR1 in disease	32	9.67e-04	0.337000	7.39e-03
Signaling by MST1	5	1.92e-01	-0.337000	3.88e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	1.54e-01	-0.336000	3.47e-01
FGFR1 mutant receptor activation	25	3.66e-03	0.336000	2.21e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	5.90e-06	-0.335000	7.87e-05
PERK regulates gene expression	30	1.48e-03	-0.335000	1.04e-02
Role of phospholipids in phagocytosis	88	5.40e-08	-0.335000	1.27e-06
Signaling by Erythropoietin	24	4.58e-03	0.334000	2.65e-02
Signaling by FGFR4 in disease	11	5.55e-02	0.333000	1.76e-01
XBP1(S) activates chaperone genes	44	1.31e-04	-0.333000	1.30e-03
Establishment of Sister Chromatid Cohesion	11	5.62e-02	0.332000	1.78e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	1.87e-06	-0.332000	2.98e-05
VLDLR internalisation and degradation	16	2.16e-02	-0.332000	9.08e-02
Synthesis of wybutosine at G37 of tRNA(Phe)	6	1.60e-01	-0.331000	3.55e-01
Aflatoxin activation and detoxification	14	3.19e-02	-0.331000	1.21e-01
PI-3K cascade:FGFR2	13	3.91e-02	0.331000	1.41e-01
Cholesterol biosynthesis	26	3.54e-03	-0.330000	2.18e-02
Prolonged ERK activation events	13	3.93e-02	0.330000	1.41e-01
Regulation of NPAS4 gene expression	11	5.84e-02	0.330000	1.82e-01
ABC transporter disorders	60	1.09e-05	-0.328000	1.40e-04
Assembly of the pre-replicative complex	87	1.23e-07	-0.328000	2.70e-06
Regulation of RAS by GAPs	55	2.66e-05	-0.327000	3.04e-04
Erythrocytes take up oxygen and release carbon dioxide	7	1.34e-01	0.327000	3.19e-01
Glutathione conjugation	28	2.77e-03	-0.327000	1.76e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	4.16e-02	-0.326000	1.45e-01
Zinc influx into cells by the SLC39 gene family	9	9.01e-02	-0.326000	2.45e-01
RHOBTB3 ATPase cycle	10	7.47e-02	-0.325000	2.16e-01
DNA Replication Pre-Initiation	103	1.23e-08	-0.325000	3.34e-07
Hydrolysis of LPC	8	1.12e-01	0.325000	2.85e-01
NFE2L2 regulating ER-stress associated genes	5	2.11e-01	0.323000	4.13e-01
Ras activation upon Ca2+ influx through NMDA receptor	18	1.76e-02	0.323000	7.88e-02
Formation of definitive endoderm	9	9.32e-02	0.323000	2.50e-01
Metabolism of cofactors	25	5.15e-03	-0.323000	2.91e-02
RORA activates gene expression	18	1.76e-02	0.323000	7.88e-02
Activation of BAD and translocation to mitochondria	15	3.03e-02	-0.323000	1.17e-01
Base Excision Repair	57	2.46e-05	-0.323000	2.83e-04
Biosynthesis of maresins	7	1.39e-01	0.323000	3.24e-01
IRE1alpha activates chaperones	46	1.55e-04	-0.322000	1.48e-03
UCH proteinases	73	1.92e-06	-0.322000	3.05e-05
Bicarbonate transporters	9	9.62e-02	0.320000	2.56e-01
ATF4 activates genes in response to endoplasmic reticulum stress	25	5.61e-03	-0.320000	3.13e-02
Inhibition of Signaling by Overexpressed EGFR	6	1.76e-01	0.319000	3.71e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	6	1.76e-01	0.319000	3.71e-01
Butyrophilin (BTN) family interactions	9	9.75e-02	0.319000	2.58e-01
tRNA modification in the nucleus and cytosol	43	3.00e-04	-0.319000	2.65e-03
FCERI mediated MAPK activation	93	1.10e-07	-0.318000	2.47e-06
Maturation of spike protein 9694548	36	9.50e-04	-0.318000	7.28e-03
Fibronectin matrix formation	6	1.77e-01	-0.318000	3.72e-01
Downstream signaling of activated FGFR3	17	2.32e-02	0.318000	9.56e-02
Dectin-1 mediated noncanonical NF-kB signaling	48	1.41e-04	-0.317000	1.39e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	4.76e-02	-0.317000	1.60e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	4.77e-02	-0.317000	1.60e-01
PRC2 methylates histones and DNA	27	4.41e-03	-0.317000	2.56e-02
Synthesis of PIPs at the late endosome membrane	11	6.93e-02	0.316000	2.06e-01
Josephin domain DUBs	10	8.36e-02	-0.316000	2.33e-01
CREB phosphorylation	7	1.49e-01	0.315000	3.40e-01
FGFR2b ligand binding and activation	6	1.83e-01	-0.314000	3.77e-01
MASTL Facilitates Mitotic Progression	10	8.59e-02	-0.314000	2.38e-01
APC/C-mediated degradation of cell cycle proteins	75	2.65e-06	-0.314000	3.99e-05
Regulation of mitotic cell cycle	75	2.65e-06	-0.314000	3.99e-05
IkBA variant leads to EDA-ID	7	1.52e-01	0.313000	3.44e-01
PINK1-PRKN Mediated Mitophagy	31	2.63e-03	-0.312000	1.69e-02
Diseases associated with surfactant metabolism	6	1.86e-01	0.312000	3.80e-01
Interleukin-21 signaling	9	1.06e-01	0.312000	2.72e-01
MAPK3 (ERK1) activation	10	8.95e-02	0.310000	2.44e-01
Mitochondrial Fatty Acid Beta-Oxidation	36	1.36e-03	-0.308000	9.65e-03
Cellular response to hypoxia	59	4.29e-05	-0.308000	4.82e-04
Formation of paraxial mesoderm	52	1.24e-04	-0.308000	1.25e-03
FCERI mediated Ca+2 mobilization	92	3.57e-07	-0.307000	7.11e-06
Biosynthesis of maresin-like SPMs	5	2.35e-01	0.307000	4.41e-01
Unfolded Protein Response (UPR)	84	1.17e-06	-0.307000	1.95e-05
mRNA Splicing - Minor Pathway	50	1.90e-04	-0.305000	1.75e-03
Interleukin-6 family signaling	20	1.82e-02	0.305000	8.02e-02
ChREBP activates metabolic gene expression	7	1.63e-01	-0.304000	3.58e-01
Regulation of PTEN stability and activity	55	9.43e-05	-0.304000	9.74e-04
Removal of the Flap Intermediate	14	4.87e-02	-0.304000	1.62e-01
Glyoxylate metabolism and glycine degradation	13	5.75e-02	-0.304000	1.80e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	4.58e-06	-0.304000	6.15e-05
Sensing of DNA Double Strand Breaks	6	1.98e-01	0.304000	3.95e-01
Signaling by ERBB2 KD Mutants	20	1.88e-02	0.303000	8.21e-02
TRAIL signaling	8	1.38e-01	0.303000	3.21e-01
PI-3K cascade:FGFR1	13	5.90e-02	0.302000	1.83e-01
Interleukin receptor SHC signaling	23	1.21e-02	0.302000	5.92e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	2.02e-01	-0.301000	4.02e-01
Switching of origins to a post-replicative state	79	4.13e-06	-0.300000	5.61e-05
GRB2 events in EGFR signaling	11	8.61e-02	0.299000	2.38e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	7.33e-02	-0.299000	2.14e-01
Transport of connexons to the plasma membrane	12	7.33e-02	-0.299000	2.14e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	1.72e-01	0.298000	3.69e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	3.33e-02	0.298000	1.26e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	2.11e-02	-0.298000	8.95e-02
Transcriptional regulation of pluripotent stem cells	21	1.82e-02	0.298000	8.01e-02
Cyclin A:Cdk2-associated events at S phase entry	75	8.99e-06	-0.296000	1.18e-04
Interleukin-20 family signaling	17	3.43e-02	0.296000	1.29e-01
Cyclin E associated events during G1/S transition	73	1.19e-05	-0.296000	1.48e-04
Receptor-type tyrosine-protein phosphatases	12	7.68e-02	0.295000	2.20e-01
HSF1 activation	26	9.37e-03	-0.294000	4.80e-02
Unwinding of DNA	12	7.84e-02	-0.293000	2.23e-01
Cellular response to mitochondrial stress	9	1.28e-01	-0.293000	3.10e-01
Interconversion of nucleotide di- and triphosphates	27	8.71e-03	-0.292000	4.50e-02
IRAK4 deficiency (TLR2/4)	15	5.06e-02	0.292000	1.67e-01
Metabolism of RNA	718	2.19e-40	-0.291000	7.06e-38
Formation of the Early Elongation Complex	33	3.87e-03	-0.291000	2.30e-02
Formation of the HIV-1 Early Elongation Complex	33	3.87e-03	-0.291000	2.30e-02
Axonal growth inhibition (RHOA activation)	7	1.83e-01	-0.290000	3.77e-01
p75NTR regulates axonogenesis	7	1.83e-01	-0.290000	3.77e-01
MAPK1 (ERK2) activation	9	1.32e-01	0.290000	3.16e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	3.90e-02	-0.289000	1.41e-01
Diseases of programmed cell death	58	1.43e-04	-0.289000	1.40e-03
FRS-mediated FGFR3 signaling	12	8.37e-02	0.288000	2.33e-01
Lysosphingolipid and LPA receptors	11	9.79e-02	-0.288000	2.58e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	1.58e-01	0.288000	3.53e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	1.59e-01	-0.288000	3.54e-01
MyD88 deficiency (TLR2/4)	14	6.23e-02	0.288000	1.91e-01
Cross-presentation of particulate exogenous antigens (phagosomes)	8	1.59e-01	0.288000	3.54e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	1.28e-03	-0.287000	9.15e-03
HIV Transcription Elongation	42	1.28e-03	-0.287000	9.15e-03
Tat-mediated elongation of the HIV-1 transcript	42	1.28e-03	-0.287000	9.15e-03
DNA replication initiation	8	1.60e-01	-0.287000	3.55e-01
Class I peroxisomal membrane protein import	20	2.63e-02	-0.287000	1.04e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	6.31e-02	-0.287000	1.91e-01
p75NTR negatively regulates cell cycle via SC1	5	2.67e-01	-0.287000	4.77e-01
Signaling by FGFR2 IIIa TM	18	3.53e-02	-0.287000	1.31e-01
POLB-Dependent Long Patch Base Excision Repair	8	1.60e-01	-0.287000	3.55e-01
Basigin interactions	23	1.76e-02	-0.286000	7.88e-02
Apoptosis induced DNA fragmentation	10	1.18e-01	-0.286000	2.96e-01
p75NTR recruits signalling complexes	12	8.72e-02	-0.285000	2.40e-01
RNA Polymerase III Transcription Termination	23	1.82e-02	-0.285000	8.01e-02
RUNX1 regulates transcription of genes involved in WNT signaling	5	2.71e-01	0.284000	4.77e-01
Replacement of protamines by nucleosomes in the male pronucleus	13	7.68e-02	-0.283000	2.20e-01
Transcriptional regulation by RUNX2	92	2.62e-06	-0.283000	3.99e-05
RNA Polymerase III Transcription Initiation	36	3.29e-03	-0.283000	2.05e-02
Synthesis of PIPs at the early endosome membrane	16	5.02e-02	0.283000	1.66e-01
Synthesis of DNA	108	3.91e-07	-0.282000	7.71e-06
FCGR3A-mediated IL10 synthesis	99	1.20e-06	-0.282000	1.98e-05
Nuclear events mediated by NFE2L2	82	9.89e-06	-0.282000	1.27e-04
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	1.96e-01	0.282000	3.93e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	5.08e-02	0.282000	1.67e-01
DNA Replication	128	3.77e-08	-0.281000	9.21e-07
Frs2-mediated activation	11	1.07e-01	0.281000	2.74e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	1.73e-02	-0.281000	7.80e-02
Small interfering RNA (siRNA) biogenesis	9	1.46e-01	0.280000	3.35e-01
LTC4-CYSLTR mediated IL4 production	5	2.79e-01	0.280000	4.87e-01
Triglyceride biosynthesis	10	1.26e-01	0.279000	3.08e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	83	1.15e-05	-0.278000	1.46e-04
Defective Intrinsic Pathway for Apoptosis	24	1.85e-02	-0.278000	8.10e-02
Nef Mediated CD4 Down-regulation	9	1.49e-01	-0.278000	3.40e-01
NF-kB is activated and signals survival	12	9.59e-02	-0.278000	2.56e-01
FLT3 signaling by CBL mutants	7	2.03e-01	-0.278000	4.04e-01
Physiological factors	9	1.49e-01	0.278000	3.40e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	1.46e-02	0.277000	6.80e-02
Phospholipase C-mediated cascade; FGFR3	5	2.84e-01	0.277000	4.94e-01
Transport of RCbl within the body	8	1.76e-01	-0.277000	3.71e-01
Processing of Capped Intronless Pre-mRNA	29	9.97e-03	-0.276000	5.03e-02
Mitophagy	38	3.28e-03	-0.276000	2.04e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	2.08e-01	-0.275000	4.09e-01
Plasma lipoprotein clearance	33	6.24e-03	-0.275000	3.41e-02
Metabolism of nucleotides	85	1.17e-05	-0.275000	1.47e-04
tRNA processing in the nucleus	59	2.71e-04	-0.274000	2.41e-03
Interleukin-10 signaling	38	3.57e-03	0.273000	2.19e-02
GABA receptor activation	38	3.59e-03	0.273000	2.19e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	1.36e-01	-0.272000	3.20e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.37e-01	-0.272000	3.21e-01
Synthesis of substrates in N-glycan biosythesis	59	3.17e-04	-0.271000	2.76e-03
Azathioprine ADME	21	3.16e-02	-0.271000	1.21e-01
IL-6-type cytokine receptor ligand interactions	13	9.21e-02	0.270000	2.48e-01
ERBB2 Regulates Cell Motility	10	1.40e-01	0.269000	3.25e-01
Defective binding of VWF variant to GPIb:IX:V	7	2.18e-01	-0.269000	4.20e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	7	2.18e-01	-0.269000	4.20e-01
Organic cation transport	8	1.88e-01	0.269000	3.81e-01
Organic cation/anion/zwitterion transport	8	1.88e-01	0.269000	3.81e-01
ERBB2 Activates PTK6 Signaling	8	1.89e-01	0.268000	3.82e-01
Resolution of Abasic Sites (AP sites)	38	4.27e-03	-0.268000	2.49e-02
Host Interactions of HIV factors	118	5.14e-07	-0.268000	9.46e-06
Signaling by PDGFR in disease	19	4.39e-02	0.267000	1.51e-01
Recycling of bile acids and salts	10	1.44e-01	0.267000	3.33e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	7.30e-05	-0.267000	7.75e-04
CYP2E1 reactions	6	2.59e-01	0.266000	4.68e-01
RNA Polymerase I Transcription Termination	30	1.17e-02	-0.266000	5.75e-02
Heme signaling	45	2.03e-03	0.266000	1.37e-02
TRIF-mediated programmed cell death	9	1.68e-01	0.266000	3.64e-01
Downstream signaling of activated FGFR4	18	5.11e-02	0.266000	1.67e-01
Assembly of active LPL and LIPC lipase complexes	10	1.46e-01	-0.266000	3.35e-01
Intrinsic Pathway for Apoptosis	54	7.58e-04	-0.265000	5.97e-03
Phase 0 - rapid depolarisation	24	2.47e-02	0.265000	1.00e-01
p130Cas linkage to MAPK signaling for integrins	11	1.28e-01	-0.265000	3.11e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	2.39e-03	-0.265000	1.55e-02
Androgen biosynthesis	5	3.06e-01	0.265000	5.18e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.23e-02	0.264000	9.31e-02
GRB2 events in ERBB2 signaling	11	1.29e-01	0.264000	3.13e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	2.27e-01	-0.264000	4.31e-01
Processive synthesis on the lagging strand	15	7.90e-02	-0.262000	2.24e-01
Acyl chain remodelling of PC	19	4.81e-02	0.262000	1.61e-01
Telomere Extension By Telomerase	23	3.01e-02	-0.261000	1.16e-01
Fructose metabolism	7	2.32e-01	-0.261000	4.37e-01
DAP12 interactions	39	4.86e-03	0.261000	2.79e-02
Metabolism of non-coding RNA	53	1.07e-03	-0.260000	8.05e-03
snRNP Assembly	53	1.07e-03	-0.260000	8.05e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	9.83e-03	0.260000	4.97e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	18	5.68e-02	0.259000	1.78e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	8.22e-03	-0.258000	4.32e-02
G1/S Transition	120	1.07e-06	-0.258000	1.82e-05
Glutathione synthesis and recycling	10	1.59e-01	-0.257000	3.54e-01
Cation-coupled Chloride cotransporters	6	2.76e-01	0.257000	4.83e-01
P2Y receptors	10	1.60e-01	0.257000	3.55e-01
Formation of annular gap junctions	10	1.61e-01	-0.256000	3.55e-01
Rap1 signalling	14	9.75e-02	0.256000	2.58e-01
FGFR2 mutant receptor activation	23	3.38e-02	-0.256000	1.27e-01
SARS-CoV-1-host interactions	95	1.67e-05	-0.256000	1.98e-04
VEGF binds to VEGFR leading to receptor dimerization	5	3.23e-01	-0.255000	5.40e-01
VEGF ligand-receptor interactions	5	3.23e-01	-0.255000	5.40e-01
Insulin processing	19	5.46e-02	0.255000	1.75e-01
ER-Phagosome pathway	75	1.37e-04	-0.255000	1.36e-03
Assembly of the ORC complex at the origin of replication	23	3.47e-02	-0.254000	1.29e-01
Activation of NF-kappaB in B cells	54	1.25e-03	-0.254000	9.10e-03
Defects of platelet adhesion to exposed collagen	8	2.14e-01	-0.254000	4.16e-01
Signaling by ERBB2 in Cancer	21	4.46e-02	0.253000	1.53e-01
Defects in vitamin and cofactor metabolism	21	4.51e-02	-0.253000	1.54e-01
Voltage gated Potassium channels	26	2.61e-02	0.252000	1.03e-01
Mitochondrial Uncoupling	6	2.89e-01	-0.250000	4.99e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	2.52e-01	0.250000	4.60e-01
SMAC (DIABLO) binds to IAPs	7	2.52e-01	-0.250000	4.60e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	2.52e-01	-0.250000	4.60e-01
SMAC, XIAP-regulated apoptotic response	7	2.52e-01	-0.250000	4.60e-01
Transcriptional Regulation by NPAS4	27	2.49e-02	0.249000	1.00e-01
Diseases of branched-chain amino acid catabolism	13	1.20e-01	-0.249000	3.01e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.07e-01	-0.249000	2.74e-01
B-WICH complex positively regulates rRNA expression	45	3.90e-03	-0.249000	2.30e-02
Hedgehog ‘on’ state	65	5.26e-04	-0.249000	4.34e-03
CaMK IV-mediated phosphorylation of CREB	9	1.97e-01	0.249000	3.94e-01
Free fatty acids regulate insulin secretion	10	1.74e-01	0.248000	3.71e-01
Impaired BRCA2 binding to PALB2	24	3.55e-02	0.248000	1.31e-01
Processing and activation of SUMO	10	1.75e-01	-0.248000	3.71e-01
Regulation of CDH11 Expression and Function	23	3.99e-02	0.247000	1.41e-01
Association of TriC/CCT with target proteins during biosynthesis	35	1.15e-02	-0.247000	5.72e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	1.93e-02	-0.247000	8.39e-02
RHO GTPases Activate Rhotekin and Rhophilins	8	2.28e-01	-0.246000	4.31e-01
Heme degradation	11	1.57e-01	-0.246000	3.52e-01
Metabolism of porphyrins	23	4.10e-02	-0.246000	1.44e-01
CRMPs in Sema3A signaling	13	1.25e-01	0.246000	3.07e-01
N-glycan antennae elongation in the medial/trans-Golgi	21	5.13e-02	-0.246000	1.68e-01
RNA Polymerase I Promoter Clearance	64	6.77e-04	-0.246000	5.43e-03
RNA Polymerase I Transcription	64	6.77e-04	-0.246000	5.43e-03
Fructose catabolism	5	3.43e-01	-0.245000	5.61e-01
Negative epigenetic regulation of rRNA expression	63	8.03e-04	-0.244000	6.23e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	1.61e-01	-0.244000	3.55e-01
Erythropoietin activates RAS	13	1.28e-01	0.244000	3.11e-01
SOS-mediated signalling	7	2.64e-01	0.244000	4.74e-01
Pregnenolone biosynthesis	10	1.83e-01	-0.243000	3.77e-01
ABC-family proteins mediated transport	81	1.56e-04	-0.243000	1.48e-03
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.63e-01	-0.243000	3.58e-01
Telomere Maintenance	78	2.13e-04	-0.242000	1.94e-03
Myogenesis	21	5.48e-02	0.242000	1.75e-01
SHC-mediated cascade:FGFR3	10	1.85e-01	0.242000	3.80e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	9.55e-02	0.241000	2.55e-01
G beta:gamma signalling through CDC42	17	8.61e-02	0.240000	2.38e-01
Activation of G protein gated Potassium channels	20	6.29e-02	0.240000	1.91e-01
G protein gated Potassium channels	20	6.29e-02	0.240000	1.91e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	6.29e-02	0.240000	1.91e-01
Polo-like kinase mediated events	16	9.63e-02	-0.240000	2.56e-01
Uptake and function of anthrax toxins	11	1.69e-01	0.240000	3.66e-01
EGFR Transactivation by Gastrin	7	2.73e-01	0.239000	4.79e-01
MicroRNA (miRNA) biogenesis	24	4.24e-02	-0.239000	1.47e-01
Lewis blood group biosynthesis	14	1.22e-01	-0.239000	3.04e-01
Activation of BH3-only proteins	30	2.39e-02	-0.238000	9.77e-02
Transcriptional regulation by small RNAs	61	1.29e-03	-0.238000	9.15e-03
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	3.57e-01	-0.238000	5.73e-01
Regulation of MECP2 expression and activity	29	2.71e-02	0.237000	1.06e-01
Formation of TC-NER Pre-Incision Complex	51	3.49e-03	-0.236000	2.15e-02
Mitotic G1 phase and G1/S transition	138	1.67e-06	-0.236000	2.72e-05
Removal of the Flap Intermediate from the C-strand	17	9.21e-02	-0.236000	2.48e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	9.21e-02	-0.236000	2.48e-01
EGFR interacts with phospholipase C-gamma	7	2.80e-01	0.236000	4.88e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	3.16e-02	-0.235000	1.21e-01
Paracetamol ADME	19	7.68e-02	-0.235000	2.20e-01
Cell surface interactions at the vascular wall	176	7.98e-08	-0.234000	1.84e-06
KEAP1-NFE2L2 pathway	107	2.95e-05	-0.234000	3.36e-04
Long-term potentiation	18	8.67e-02	0.233000	2.39e-01
eNOS activation	12	1.62e-01	-0.233000	3.57e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	1.63e-01	-0.233000	3.58e-01
Branched-chain amino acid catabolism	21	6.50e-02	-0.233000	1.95e-01
Signaling by the B Cell Receptor (BCR)	150	9.26e-07	-0.232000	1.61e-05
Metabolism of amine-derived hormones	10	2.04e-01	0.232000	4.05e-01
Signaling by NOTCH4	70	7.90e-04	-0.232000	6.18e-03
Acyl chain remodelling of PS	14	1.34e-01	0.231000	3.19e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	5.48e-02	-0.231000	1.75e-01
Regulation of actin dynamics for phagocytic cup formation	123	9.36e-06	-0.231000	1.21e-04
Activation of GABAB receptors	31	2.58e-02	0.231000	1.03e-01
GABA B receptor activation	31	2.58e-02	0.231000	1.03e-01
Relaxin receptors	5	3.71e-01	0.231000	5.86e-01
Zinc transporters	12	1.66e-01	-0.231000	3.62e-01
G2/M DNA replication checkpoint	5	3.71e-01	-0.231000	5.86e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	3.71e-01	-0.231000	5.86e-01
NoRC negatively regulates rRNA expression	60	1.98e-03	-0.231000	1.34e-02
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	1.35e-01	0.231000	3.19e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.35e-01	-0.231000	3.19e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	5.77e-03	-0.230000	3.19e-02
CLEC7A (Dectin-1) induces NFAT activation	11	1.86e-01	0.230000	3.80e-01
Downstream signaling of activated FGFR1	22	6.21e-02	0.230000	1.90e-01
FCGR3A-mediated phagocytosis	121	1.30e-05	-0.229000	1.56e-04
Leishmania phagocytosis	121	1.30e-05	-0.229000	1.56e-04
Parasite infection	121	1.30e-05	-0.229000	1.56e-04
Regulation of TP53 Activity through Methylation	19	8.33e-02	-0.229000	2.33e-01
Regulation of NFE2L2 gene expression	8	2.61e-01	0.229000	4.70e-01
Nef Mediated CD8 Down-regulation	7	2.93e-01	-0.229000	5.04e-01
FGFR1b ligand binding and activation	5	3.75e-01	-0.229000	5.89e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	4.78e-02	-0.229000	1.61e-01
Inwardly rectifying K+ channels	24	5.26e-02	0.229000	1.71e-01
ROBO receptors bind AKAP5	7	2.98e-01	0.227000	5.11e-01
Activation of the pre-replicative complex	32	2.62e-02	-0.227000	1.04e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	1.56e-02	-0.227000	7.16e-02
Nucleosome assembly	38	1.56e-02	-0.227000	7.16e-02
Activated NTRK2 signals through FRS2 and FRS3	8	2.67e-01	0.226000	4.77e-01
Regulation of Expression and Function of Type II Classical Cadherins	25	5.02e-02	0.226000	1.66e-01
Regulation of Homotypic Cell-Cell Adhesion	25	5.02e-02	0.226000	1.66e-01
Diseases of hemostasis	15	1.30e-01	-0.226000	3.13e-01
Caspase activation via Death Receptors in the presence of ligand	16	1.19e-01	0.225000	2.97e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.77e-01	-0.225000	3.72e-01
Dermatan sulfate biosynthesis	6	3.39e-01	-0.225000	5.57e-01
Biosynthesis of E-series 18(S)-resolvins	5	3.85e-01	-0.224000	5.98e-01
Beta-oxidation of pristanoyl-CoA	9	2.44e-01	-0.224000	4.53e-01
SHC1 events in EGFR signaling	12	1.79e-01	0.224000	3.75e-01
Cellular responses to stress	698	6.16e-24	-0.224000	3.72e-22
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	5.31e-02	0.223000	1.71e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	5.31e-02	0.223000	1.71e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	5.31e-02	0.223000	1.71e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	5.31e-02	0.223000	1.71e-01
PIWI-interacting RNA (piRNA) biogenesis	23	6.37e-02	-0.223000	1.92e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	5.36e-02	-0.223000	1.72e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.49e-01	-0.223000	3.40e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	1.35e-01	-0.223000	3.19e-01
Aggrephagy	34	2.49e-02	-0.222000	1.00e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	1.50e-01	0.222000	3.41e-01
Cytochrome c-mediated apoptotic response	13	1.67e-01	-0.221000	3.64e-01
Activated NTRK3 signals through RAS	7	3.11e-01	0.221000	5.24e-01
RNA Polymerase III Abortive And Retractive Initiation	41	1.42e-02	-0.221000	6.68e-02
RNA Polymerase III Transcription	41	1.42e-02	-0.221000	6.68e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	3.12e-01	0.221000	5.25e-01
Growth hormone receptor signaling	21	8.00e-02	0.221000	2.26e-01
Tryptophan catabolism	12	1.86e-01	0.220000	3.80e-01
Downstream signaling of activated FGFR2	20	8.81e-02	0.220000	2.42e-01
Impaired BRCA2 binding to RAD51	35	2.45e-02	0.220000	9.95e-02
DNA Damage/Telomere Stress Induced Senescence	42	1.38e-02	-0.220000	6.50e-02
Condensation of Prophase Chromosomes	27	4.85e-02	-0.219000	1.62e-01
Negative feedback regulation of MAPK pathway	6	3.52e-01	0.219000	5.70e-01
HCMV Early Events	84	5.21e-04	-0.219000	4.32e-03
HCMV Infection	106	9.86e-05	-0.219000	1.01e-03
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	6.35e-02	0.219000	1.92e-01
WNT5A-dependent internalization of FZD4	13	1.72e-01	-0.219000	3.69e-01
Erythrocytes take up carbon dioxide and release oxygen	11	2.10e-01	0.218000	4.11e-01
O2/CO2 exchange in erythrocytes	11	2.10e-01	0.218000	4.11e-01
FRS-mediated FGFR4 signaling	13	1.74e-01	0.218000	3.70e-01
Degradation of beta-catenin by the destruction complex	72	1.38e-03	-0.218000	9.74e-03
Diseases associated with the TLR signaling cascade	29	4.22e-02	0.218000	1.47e-01
Diseases of Immune System	29	4.22e-02	0.218000	1.47e-01
Role of second messengers in netrin-1 signaling	6	3.57e-01	-0.217000	5.73e-01
G beta:gamma signalling through BTK	15	1.46e-01	0.217000	3.35e-01
Serine biosynthesis	8	2.89e-01	0.217000	4.99e-01
Regulation of FOXO transcriptional activity by acetylation	10	2.36e-01	0.216000	4.42e-01
HCMV Late Events	67	2.23e-03	-0.216000	1.47e-02
Other semaphorin interactions	16	1.35e-01	0.216000	3.19e-01
Interleukin-2 family signaling	38	2.13e-02	0.216000	8.95e-02
Gap junction assembly	17	1.24e-01	-0.215000	3.06e-01
RAS processing	23	7.40e-02	-0.215000	2.16e-01
Disorders of transmembrane transporters	137	1.38e-05	-0.215000	1.65e-04
Adenylate cyclase inhibitory pathway	11	2.18e-01	0.215000	4.20e-01
Pentose phosphate pathway	13	1.82e-01	-0.214000	3.77e-01
Eicosanoids	6	3.65e-01	0.214000	5.81e-01
HIV Infection	213	7.92e-08	-0.213000	1.84e-06
Mismatch Repair	15	1.53e-01	-0.213000	3.45e-01
Viral Messenger RNA Synthesis	44	1.45e-02	-0.213000	6.76e-02
Synthesis of PIPs at the plasma membrane	52	8.09e-03	0.212000	4.28e-02
Positive epigenetic regulation of rRNA expression	60	4.45e-03	-0.212000	2.58e-02
Ca2+ pathway	58	5.22e-03	0.212000	2.94e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	7.84e-04	-0.212000	6.16e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	1.51e-02	0.212000	6.98e-02
Nucleotide Excision Repair	108	1.45e-04	-0.212000	1.41e-03
TRAF3-dependent IRF activation pathway	13	1.88e-01	0.211000	3.81e-01
SHC-related events triggered by IGF1R	8	3.02e-01	0.211000	5.14e-01
G2/M Checkpoints	126	4.40e-05	-0.211000	4.88e-04
Viral Infection Pathways	776	1.60e-23	-0.211000	9.38e-22
Formyl peptide receptors bind formyl peptides and many other ligands	7	3.34e-01	-0.211000	5.52e-01
Peroxisomal protein import	58	5.54e-03	-0.211000	3.10e-02
Constitutive Signaling by EGFRvIII	14	1.73e-01	0.210000	3.69e-01
Signaling by EGFRvIII in Cancer	14	1.73e-01	0.210000	3.69e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	3.35e-01	-0.210000	5.52e-01
InlA-mediated entry of Listeria monocytogenes into host cells	9	2.76e-01	-0.210000	4.83e-01
Platelet degranulation	106	1.93e-04	-0.210000	1.77e-03
Dual Incision in GG-NER	41	2.04e-02	-0.209000	8.76e-02
Metabolism of nitric oxide: NOS3 activation and regulation	15	1.61e-01	-0.209000	3.55e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	7.73e-02	-0.208000	2.21e-01
Glycogen breakdown (glycogenolysis)	12	2.12e-01	0.208000	4.13e-01
Protein folding	83	1.04e-03	-0.208000	7.91e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.72e-03	-0.208000	1.18e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	9.95e-02	-0.208000	2.61e-01
Neurodegenerative Diseases	21	9.95e-02	-0.208000	2.61e-01
Signaling by PDGFRA extracellular domain mutants	12	2.13e-01	0.207000	4.15e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	2.13e-01	0.207000	4.15e-01
Signaling by FLT3 ITD and TKD mutants	15	1.67e-01	0.206000	3.64e-01
Cytochrome P450 - arranged by substrate type	38	2.81e-02	0.206000	1.09e-01
Regulation of innate immune responses to cytosolic DNA	14	1.84e-01	-0.205000	3.77e-01
FOXO-mediated transcription of cell cycle genes	15	1.70e-01	0.205000	3.67e-01
FGFR4 ligand binding and activation	5	4.29e-01	0.204000	6.37e-01
NFE2L2 regulating MDR associated enzymes	8	3.17e-01	0.204000	5.33e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	4.30e-01	-0.204000	6.38e-01
Diseases of carbohydrate metabolism	29	5.75e-02	-0.204000	1.80e-01
ADP signalling through P2Y purinoceptor 12	18	1.35e-01	0.203000	3.19e-01
Retrograde neurotrophin signalling	12	2.23e-01	-0.203000	4.25e-01
S Phase	150	1.84e-05	-0.203000	2.16e-04
NrCAM interactions	6	3.90e-01	0.203000	6.03e-01
Suppression of apoptosis	7	3.54e-01	-0.202000	5.72e-01
Fc epsilon receptor (FCERI) signaling	179	3.14e-06	-0.202000	4.60e-05
RNA Polymerase I Transcription Initiation	47	1.68e-02	-0.202000	7.63e-02
Acyl chain remodelling of PG	11	2.47e-01	0.201000	4.56e-01
RMTs methylate histone arginines	35	3.95e-02	-0.201000	1.41e-01
Transport of vitamins, nucleosides, and related molecules	32	4.92e-02	-0.201000	1.64e-01
Asparagine N-linked glycosylation	286	5.26e-09	-0.201000	1.49e-07
Histidine catabolism	7	3.58e-01	0.200000	5.75e-01
TRAF6 mediated IRF7 activation	15	1.81e-01	0.200000	3.76e-01
Glycosphingolipid catabolism	31	5.48e-02	-0.199000	1.75e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	1.23e-01	0.199000	3.05e-01
Trafficking of AMPA receptors	20	1.23e-01	0.199000	3.05e-01
Transcription of the HIV genome	67	4.83e-03	-0.199000	2.78e-02
Cellular responses to stimuli	779	3.15e-21	-0.199000	1.60e-19
SARS-CoV-2-host interactions	183	3.54e-06	-0.199000	5.07e-05
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	4.43e-01	-0.198000	6.50e-01
Nef and signal transduction	8	3.32e-01	0.198000	5.49e-01
Striated Muscle Contraction	27	7.48e-02	0.198000	2.16e-01
Signaling by TGFBR3	39	3.23e-02	0.198000	1.22e-01
SARS-CoV-1 Infection	138	5.89e-05	-0.198000	6.46e-04
Metabolism of Angiotensinogen to Angiotensins	12	2.36e-01	0.198000	4.42e-01
PI3K/AKT activation	8	3.33e-01	0.198000	5.51e-01
NFE2L2 regulating tumorigenic genes	11	2.57e-01	0.197000	4.65e-01
Erythropoietin activates STAT5	6	4.03e-01	0.197000	6.14e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	2.54e-02	-0.197000	1.02e-01
Regulation of insulin secretion	63	6.86e-03	0.197000	3.73e-02
Selective autophagy	77	2.91e-03	-0.196000	1.85e-02
LDL clearance	18	1.50e-01	-0.196000	3.41e-01
Expression and translocation of olfactory receptors	56	1.14e-02	0.196000	5.67e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	2.22e-01	-0.195000	4.24e-01
APC-Cdc20 mediated degradation of Nek2A	26	8.47e-02	-0.195000	2.35e-01
mRNA Capping	29	6.91e-02	-0.195000	2.05e-01
Meiotic recombination	37	4.04e-02	-0.195000	1.42e-01
Metabolism of proteins	1777	2.85e-42	-0.194000	1.10e-39
Interleukin-15 signaling	14	2.08e-01	0.194000	4.11e-01
mTORC1-mediated signalling	24	9.97e-02	-0.194000	2.61e-01
NPAS4 regulates expression of target genes	16	1.79e-01	0.194000	3.75e-01
TP53 Regulates Metabolic Genes	78	3.17e-03	-0.193000	1.98e-02
Proton-coupled monocarboxylate transport	6	4.13e-01	-0.193000	6.22e-01
PCNA-Dependent Long Patch Base Excision Repair	21	1.26e-01	-0.193000	3.08e-01
Response to elevated platelet cytosolic Ca2+	110	4.97e-04	-0.192000	4.14e-03
Regulation of NF-kappa B signaling	18	1.58e-01	-0.192000	3.54e-01
RNA Polymerase II Transcription Termination	66	7.00e-03	-0.192000	3.78e-02
FLT3 signaling in disease	27	8.43e-02	0.192000	2.34e-01
Signaling by ERBB2 TMD/JMD mutants	17	1.72e-01	0.192000	3.69e-01
Lysosome Vesicle Biogenesis	32	6.11e-02	-0.191000	1.88e-01
Nucleotide catabolism	28	7.98e-02	-0.191000	2.26e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	1.36e-02	-0.191000	6.46e-02
Mitochondrial biogenesis	91	1.67e-03	-0.191000	1.15e-02
SUMOylation of DNA methylation proteins	16	1.87e-01	-0.190000	3.81e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	2.02e-01	0.190000	4.02e-01
Chromosome Maintenance	103	8.69e-04	-0.190000	6.69e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	3.25e-01	0.190000	5.42e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.76e-01	-0.189000	3.72e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.76e-01	-0.189000	3.72e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	2.05e-02	-0.189000	8.77e-02
Anti-inflammatory response favouring Leishmania parasite infection	132	1.71e-04	-0.189000	1.58e-03
Leishmania parasite growth and survival	132	1.71e-04	-0.189000	1.58e-03
DNA Double Strand Break Response	47	2.49e-02	-0.189000	1.00e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	8.92e-02	-0.189000	2.43e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	8.92e-02	-0.189000	2.43e-01
Gap junction trafficking	28	8.37e-02	-0.189000	2.33e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	3.87e-01	0.189000	6.00e-01
SUMOylation of DNA replication proteins	46	2.68e-02	-0.189000	1.06e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	1.03e-02	-0.188000	5.18e-02
Vitamin B1 (thiamin) metabolism	5	4.66e-01	-0.188000	6.71e-01
Pyroptosis	25	1.04e-01	-0.188000	2.70e-01
Aspartate and asparagine metabolism	9	3.31e-01	-0.187000	5.49e-01
RUNX3 regulates NOTCH signaling	14	2.26e-01	0.187000	4.29e-01
Senescence-Associated Secretory Phenotype (SASP)	65	9.15e-03	-0.187000	4.70e-02
Antigen processing-Cross presentation	89	2.33e-03	-0.187000	1.52e-02
Fanconi Anemia Pathway	36	5.34e-02	-0.186000	1.71e-01
Heme biosynthesis	13	2.46e-01	-0.186000	4.55e-01
ZBP1(DAI) mediated induction of type I IFNs	20	1.51e-01	0.185000	3.43e-01
Late Phase of HIV Life Cycle	131	2.52e-04	-0.185000	2.27e-03
Formation of apoptosome	11	2.88e-01	-0.185000	4.98e-01
Regulation of the apoptosome activity	11	2.88e-01	-0.185000	4.98e-01
Negative regulation of MET activity	18	1.74e-01	0.185000	3.71e-01
DNA strand elongation	32	7.03e-02	-0.185000	2.08e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	4.74e-01	0.185000	6.73e-01
Maple Syrup Urine Disease	5	4.74e-01	0.185000	6.73e-01
Regulation of RUNX1 Expression and Activity	18	1.76e-01	0.184000	3.71e-01
ALK mutants bind TKIs	11	2.90e-01	0.184000	5.00e-01
Cellular response to chemical stress	179	2.18e-05	-0.184000	2.52e-04
Signaling by KIT in disease	20	1.55e-01	0.184000	3.49e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.55e-01	0.184000	3.49e-01
Signaling by Hippo	18	1.78e-01	0.183000	3.72e-01
CTNNB1 S33 mutants aren’t phosphorylated	15	2.19e-01	0.183000	4.20e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	2.19e-01	0.183000	4.20e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	2.19e-01	0.183000	4.20e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	2.19e-01	0.183000	4.20e-01
Signaling by CTNNB1 phospho-site mutants	15	2.19e-01	0.183000	4.20e-01
Signaling by GSK3beta mutants	15	2.19e-01	0.183000	4.20e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	3.42e-01	-0.183000	5.61e-01
Translation of Structural Proteins 9694635	56	1.80e-02	-0.183000	8.00e-02
Prevention of phagosomal-lysosomal fusion	9	3.43e-01	-0.183000	5.61e-01
Rev-mediated nuclear export of HIV RNA	35	6.17e-02	-0.182000	1.90e-01
COPI-mediated anterograde transport	92	2.52e-03	-0.182000	1.63e-02
Apoptotic cleavage of cell adhesion proteins	8	3.74e-01	0.182000	5.88e-01
Synthesis of pyrophosphates in the cytosol	8	3.74e-01	-0.181000	5.88e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	2.09e-01	-0.181000	4.11e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	4.25e-02	-0.181000	1.47e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	1.04e-01	-0.181000	2.70e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	8.74e-02	-0.180000	2.40e-01
Metabolism	1835	1.58e-37	-0.180000	4.37e-35
Budding and maturation of HIV virion	26	1.13e-01	-0.180000	2.85e-01
Reelin signalling pathway	5	4.88e-01	0.179000	6.83e-01
G-protein mediated events	44	4.01e-02	0.179000	1.42e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	1.30e-01	0.179000	3.13e-01
Interactions of Rev with host cellular proteins	37	6.03e-02	-0.178000	1.86e-01
Diseases of glycosylation	109	1.29e-03	-0.178000	9.15e-03
Membrane binding and targetting of GAG proteins	13	2.66e-01	-0.178000	4.76e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	2.66e-01	-0.178000	4.76e-01
N-glycan trimming and elongation in the cis-Golgi	5	4.92e-01	-0.178000	6.87e-01
Gap junction trafficking and regulation	30	9.24e-02	-0.178000	2.49e-01
Endogenous sterols	18	1.93e-01	0.177000	3.88e-01
Phosphorylation of the APC/C	20	1.70e-01	-0.177000	3.67e-01
HIV Transcription Initiation	45	3.98e-02	-0.177000	1.41e-01
RNA Polymerase II HIV Promoter Escape	45	3.98e-02	-0.177000	1.41e-01
RNA Polymerase II Promoter Escape	45	3.98e-02	-0.177000	1.41e-01
RNA Polymerase II Transcription Initiation	45	3.98e-02	-0.177000	1.41e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	3.98e-02	-0.177000	1.41e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	3.98e-02	-0.177000	1.41e-01
RAF-independent MAPK1/3 activation	22	1.51e-01	0.177000	3.42e-01
Formation of Incision Complex in GG-NER	43	4.54e-02	-0.176000	1.54e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	3.85e-02	-0.176000	1.40e-01
Synthesis of PA	31	9.04e-02	0.176000	2.46e-01
Late endosomal microautophagy	30	9.60e-02	-0.176000	2.56e-01
Defects in cobalamin (B12) metabolism	13	2.74e-01	-0.175000	4.80e-01
SARS-CoV-2 Infection	267	8.18e-07	-0.175000	1.45e-05
G-protein beta:gamma signalling	29	1.02e-01	0.175000	2.67e-01
G-protein activation	19	1.87e-01	0.175000	3.81e-01
HDR through Single Strand Annealing (SSA)	37	6.58e-02	0.175000	1.97e-01
Downstream signaling events of B Cell Receptor (BCR)	68	1.29e-02	-0.174000	6.27e-02
CHL1 interactions	8	3.94e-01	0.174000	6.06e-01
Neddylation	215	1.10e-05	-0.174000	1.40e-04
Chaperonin-mediated protein folding	77	8.48e-03	-0.173000	4.42e-02
Translation of Structural Proteins 9683701	29	1.06e-01	-0.173000	2.72e-01
Transport of Mature Transcript to Cytoplasm	81	6.98e-03	-0.173000	3.78e-02
Signaling by Leptin	10	3.43e-01	0.173000	5.61e-01
Transport of nucleotide sugars	9	3.68e-01	-0.173000	5.85e-01
Interaction between L1 and Ankyrins	26	1.27e-01	0.173000	3.08e-01
Calnexin/calreticulin cycle	26	1.27e-01	-0.173000	3.08e-01
Olfactory Signaling Pathway	61	1.95e-02	0.173000	8.46e-02
COPI-dependent Golgi-to-ER retrograde traffic	90	4.72e-03	-0.172000	2.72e-02
Nuclear Envelope (NE) Reassembly	68	1.41e-02	-0.172000	6.65e-02
MAPK6/MAPK4 signaling	69	1.35e-02	-0.172000	6.46e-02
PI5P Regulates TP53 Acetylation	8	4.00e-01	-0.172000	6.12e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	1.03e-01	0.172000	2.68e-01
Activation of HOX genes during differentiation	70	1.30e-02	-0.172000	6.27e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	1.30e-02	-0.172000	6.27e-02
Regulation of CDH11 function	10	3.48e-01	0.171000	5.67e-01
RAC1 GTPase cycle	173	1.00e-04	0.171000	1.02e-03
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	8.85e-02	0.171000	2.42e-01
BBSome-mediated cargo-targeting to cilium	22	1.64e-01	-0.171000	3.60e-01
HIV Life Cycle	144	3.89e-04	-0.171000	3.36e-03
RHO GTPases activate PKNs	46	4.47e-02	-0.171000	1.53e-01
Collagen biosynthesis and modifying enzymes	48	4.05e-02	-0.171000	1.42e-01
Maturation of nucleoprotein 9694631	15	2.52e-01	0.171000	4.60e-01
Adherens junctions interactions	41	5.84e-02	0.171000	1.82e-01
G alpha (12/13) signalling events	68	1.49e-02	0.171000	6.92e-02
Regulation of gene expression in beta cells	8	4.03e-01	0.171000	6.14e-01
Assembly Of The HIV Virion	15	2.53e-01	-0.171000	4.60e-01
RUNX3 Regulates Immune Response and Cell Migration	6	4.70e-01	-0.171000	6.72e-01
Translesion Synthesis by POLH	18	2.11e-01	-0.170000	4.13e-01
APC truncation mutants have impaired AXIN binding	14	2.70e-01	0.170000	4.77e-01
AXIN missense mutants destabilize the destruction complex	14	2.70e-01	0.170000	4.77e-01
Signaling by AMER1 mutants	14	2.70e-01	0.170000	4.77e-01
Signaling by APC mutants	14	2.70e-01	0.170000	4.77e-01
Signaling by AXIN mutants	14	2.70e-01	0.170000	4.77e-01
Truncations of AMER1 destabilize the destruction complex	14	2.70e-01	0.170000	4.77e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	187	5.98e-05	-0.170000	6.53e-04
Loss of Function of SMAD2/3 in Cancer	7	4.36e-01	0.170000	6.43e-01
Transcriptional Regulation by MECP2	49	3.94e-02	0.170000	1.41e-01
Interleukin-7 signaling	21	1.77e-01	0.170000	3.72e-01
Peroxisomal lipid metabolism	27	1.27e-01	-0.170000	3.08e-01
Metabolism of vitamins and cofactors	166	1.59e-04	-0.170000	1.50e-03
Signaling by ERBB2 ECD mutants	15	2.55e-01	0.170000	4.62e-01
Potassium Channels	64	1.89e-02	0.170000	8.25e-02
PD-1 signaling	28	1.21e-01	-0.169000	3.02e-01
Activation of caspases through apoptosome-mediated cleavage	6	4.74e-01	-0.169000	6.73e-01
Respiratory syncytial virus (RSV) attachment and entry	18	2.15e-01	0.169000	4.17e-01
Myoclonic epilepsy of Lafora	8	4.09e-01	-0.169000	6.19e-01
Regulation of signaling by CBL	22	1.72e-01	0.168000	3.69e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.83e-01	-0.168000	3.77e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.83e-01	-0.168000	3.77e-01
Dual incision in TC-NER	63	2.13e-02	-0.168000	8.95e-02
DAP12 signaling	28	1.25e-01	0.167000	3.07e-01
Signaling by NTRK2 (TRKB)	20	1.95e-01	0.167000	3.92e-01
p75NTR signals via NF-kB	15	2.62e-01	-0.167000	4.70e-01
RHO GTPases Activate ROCKs	18	2.19e-01	0.167000	4.20e-01
TP53 Regulates Transcription of DNA Repair Genes	61	2.40e-02	-0.167000	9.79e-02
Sodium-coupled phosphate cotransporters	5	5.18e-01	-0.167000	7.08e-01
Regulation of beta-cell development	22	1.75e-01	0.167000	3.71e-01
G1/S-Specific Transcription	29	1.20e-01	-0.167000	3.00e-01
Cytosolic sulfonation of small molecules	18	2.20e-01	-0.167000	4.20e-01
Phase II - Conjugation of compounds	71	1.54e-02	-0.166000	7.07e-02
Peptide hormone metabolism	54	3.47e-02	0.166000	1.29e-01
MET receptor recycling	9	3.89e-01	0.166000	6.01e-01
Attenuation phase	23	1.69e-01	-0.166000	3.66e-01
Downstream TCR signaling	89	6.94e-03	-0.166000	3.77e-02
Late SARS-CoV-2 Infection Events	64	2.23e-02	-0.165000	9.31e-02
Regulation of TP53 Activity through Acetylation	29	1.24e-01	-0.165000	3.06e-01
Uptake and function of diphtheria toxin	6	4.84e-01	-0.165000	6.80e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	2.86e-01	0.165000	4.96e-01
Metabolism of fat-soluble vitamins	28	1.32e-01	-0.165000	3.15e-01
Downregulation of ERBB4 signaling	8	4.21e-01	-0.164000	6.30e-01
PI Metabolism	79	1.17e-02	0.164000	5.75e-02
Activation of C3 and C5	7	4.52e-01	-0.164000	6.59e-01
FRS-mediated FGFR2 signaling	15	2.72e-01	0.164000	4.78e-01
Regulation of BACH1 activity	11	3.47e-01	-0.164000	5.66e-01
RAF activation	33	1.05e-01	0.163000	2.70e-01
Ion transport by P-type ATPases	43	6.40e-02	0.163000	1.92e-01
SHC-mediated cascade:FGFR4	11	3.50e-01	0.163000	5.68e-01
SUMOylation of transcription factors	16	2.60e-01	-0.163000	4.69e-01
Infectious disease	959	1.49e-17	-0.162000	7.02e-16
Hedgehog ‘off’ state	91	7.42e-03	-0.162000	3.97e-02
Glycogen storage diseases	13	3.12e-01	-0.162000	5.25e-01
Transcriptional regulation by RUNX3	81	1.19e-02	-0.162000	5.81e-02
Scavenging by Class F Receptors	5	5.32e-01	-0.161000	7.16e-01
ABC transporters in lipid homeostasis	14	2.96e-01	0.161000	5.07e-01
Synthesis of bile acids and bile salts	27	1.49e-01	0.161000	3.40e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	1.29e-01	0.160000	3.11e-01
Formation of the active cofactor, UDP-glucuronate	5	5.36e-01	-0.160000	7.19e-01
Formation of the nephric duct	8	4.34e-01	-0.160000	6.42e-01
Diseases of metabolism	208	7.08e-05	-0.160000	7.55e-04
Apoptosis	158	5.30e-04	-0.160000	4.34e-03
Protein methylation	15	2.84e-01	-0.160000	4.94e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	7.71e-02	0.160000	2.20e-01
Diseases of DNA Double-Strand Break Repair	41	7.71e-02	0.160000	2.20e-01
Cardiac conduction	89	9.41e-03	0.159000	4.81e-02
Signaling by EGFR in Cancer	23	1.86e-01	0.159000	3.80e-01
Gene Silencing by RNA	87	1.07e-02	-0.158000	5.33e-02
Interactions of Vpr with host cellular proteins	37	9.58e-02	-0.158000	2.56e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	4.69e-01	0.158000	6.72e-01
SARS-CoV Infections	433	1.81e-08	-0.158000	4.78e-07
Nuclear import of Rev protein	34	1.12e-01	-0.157000	2.85e-01
Interleukin-1 processing	8	4.42e-01	0.157000	6.49e-01
Uptake of dietary cobalamins into enterocytes	6	5.08e-01	0.156000	7.00e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	2.52e-01	0.156000	4.60e-01
CLEC7A/inflammasome pathway	6	5.09e-01	0.156000	7.00e-01
Translocation of ZAP-70 to Immunological synapse	24	1.86e-01	-0.156000	3.80e-01
Acyl chain remodeling of CL	5	5.46e-01	0.156000	7.25e-01
Transport of the SLBP Dependant Mature mRNA	36	1.06e-01	-0.156000	2.72e-01
Regulation of HSF1-mediated heat shock response	79	1.68e-02	-0.156000	7.63e-02
N-Glycan antennae elongation	13	3.32e-01	-0.156000	5.49e-01
Activation of PUMA and translocation to mitochondria	9	4.19e-01	-0.155000	6.28e-01
Fcgamma receptor (FCGR) dependent phagocytosis	147	1.17e-03	-0.155000	8.65e-03
Nicotinate metabolism	26	1.72e-01	0.155000	3.69e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.10e-01	0.154000	2.81e-01
Glycosphingolipid biosynthesis	15	3.02e-01	0.154000	5.14e-01
PTEN Regulation	127	2.74e-03	-0.154000	1.76e-02
Regulation of IFNA/IFNB signaling	12	3.56e-01	0.154000	5.73e-01
Processive synthesis on the C-strand of the telomere	19	2.47e-01	-0.154000	4.55e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.68e-01	0.153000	3.64e-01
Glucose metabolism	76	2.08e-02	-0.153000	8.87e-02
Signaling by ERBB4	45	7.53e-02	0.153000	2.17e-01
NRIF signals cell death from the nucleus	15	3.04e-01	-0.153000	5.17e-01
MET activates RAS signaling	10	4.02e-01	0.153000	6.14e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	4.54e-01	0.153000	6.61e-01
CASP8 activity is inhibited	11	3.80e-01	0.153000	5.93e-01
Dimerization of procaspase-8	11	3.80e-01	0.153000	5.93e-01
Regulation by c-FLIP	11	3.80e-01	0.153000	5.93e-01
Linoleic acid (LA) metabolism	7	4.84e-01	-0.153000	6.80e-01
GPVI-mediated activation cascade	33	1.31e-01	0.152000	3.14e-01
Diseases of Mismatch Repair (MMR)	5	5.58e-01	-0.151000	7.34e-01
Collagen formation	66	3.37e-02	-0.151000	1.27e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	1.39e-01	-0.151000	3.24e-01
Chaperone Mediated Autophagy	20	2.45e-01	-0.150000	4.53e-01
PLC beta mediated events	40	1.00e-01	0.150000	2.62e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	2.70e-01	-0.150000	4.77e-01
Plasma lipoprotein remodeling	18	2.70e-01	-0.150000	4.77e-01
Dopamine Neurotransmitter Release Cycle	20	2.45e-01	0.150000	4.53e-01
Transport to the Golgi and subsequent modification	171	7.11e-04	-0.150000	5.68e-03
Signal amplification	28	1.69e-01	0.150000	3.67e-01
Signaling by Activin	14	3.31e-01	0.150000	5.49e-01
Cobalamin (Cbl) metabolism	7	4.93e-01	-0.150000	6.88e-01
Ca-dependent events	30	1.56e-01	0.150000	3.51e-01
Tie2 Signaling	16	3.00e-01	0.150000	5.13e-01
Recognition of DNA damage by PCNA-containing replication complex	30	1.57e-01	-0.149000	3.52e-01
Purine salvage	12	3.72e-01	-0.149000	5.86e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	5.28e-01	0.149000	7.15e-01
Constitutive Signaling by Aberrant PI3K in Cancer	59	4.90e-02	0.148000	1.63e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	1.01e-01	0.148000	2.63e-01
ADP signalling through P2Y purinoceptor 1	21	2.41e-01	0.148000	4.49e-01
Formation of RNA Pol II elongation complex	56	5.56e-02	-0.148000	1.76e-01
RNA Polymerase II Transcription Elongation	56	5.56e-02	-0.148000	1.76e-01
Gap junction degradation	11	3.97e-01	-0.148000	6.09e-01
Translesion synthesis by REV1	16	3.09e-01	-0.147000	5.22e-01
Activation of ATR in response to replication stress	37	1.23e-01	-0.147000	3.05e-01
Regulation of localization of FOXO transcription factors	11	4.00e-01	-0.146000	6.12e-01
Opioid Signalling	75	2.85e-02	0.146000	1.10e-01
Pexophagy	10	4.24e-01	-0.146000	6.32e-01
Postmitotic nuclear pore complex (NPC) reformation	27	1.90e-01	-0.146000	3.84e-01
DNA Repair	289	2.06e-05	-0.146000	2.40e-04
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	4.76e-01	0.146000	6.74e-01
Mitotic G2-G2/M phases	179	8.01e-04	-0.145000	6.23e-03
Presynaptic phase of homologous DNA pairing and strand exchange	40	1.12e-01	0.145000	2.85e-01
Acyl chain remodelling of PE	20	2.61e-01	0.145000	4.70e-01
Acetylcholine binding and downstream events	5	5.75e-01	-0.145000	7.45e-01
Postsynaptic nicotinic acetylcholine receptors	5	5.75e-01	-0.145000	7.45e-01
ERKs are inactivated	13	3.67e-01	-0.145000	5.84e-01
Extension of Telomeres	51	7.46e-02	-0.144000	2.16e-01
Defective B3GALTL causes PpS	27	1.95e-01	0.144000	3.91e-01
Norepinephrine Neurotransmitter Release Cycle	14	3.51e-01	0.144000	5.69e-01
Alpha-oxidation of phytanate	6	5.41e-01	-0.144000	7.21e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	2.32e-01	-0.144000	4.37e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	17	3.05e-01	-0.144000	5.18e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	4.55e-01	-0.144000	6.61e-01
Apoptotic cleavage of cellular proteins	35	1.41e-01	0.144000	3.27e-01
TNFR2 non-canonical NF-kB pathway	84	2.29e-02	-0.144000	9.49e-02
Amyloid fiber formation	52	7.33e-02	-0.144000	2.14e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.36e-01	-0.144000	3.20e-01
Cellular response to heat stress	94	1.65e-02	-0.143000	7.50e-02
RIP-mediated NFkB activation via ZBP1	17	3.07e-01	0.143000	5.20e-01
Infection with Mycobacterium tuberculosis	26	2.08e-01	-0.143000	4.09e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	50	8.08e-02	0.143000	2.28e-01
G2/M Transition	177	1.08e-03	-0.142000	8.05e-03
mRNA Splicing - Major Pathway	203	4.84e-04	-0.142000	4.05e-03
RAC2 GTPase cycle	86	2.31e-02	0.142000	9.56e-02
RHO GTPases activate KTN1	11	4.16e-01	0.142000	6.25e-01
Mitotic Metaphase and Anaphase	212	3.80e-04	-0.142000	3.29e-03
Signaling by WNT in cancer	30	1.80e-01	0.141000	3.75e-01
Signaling by activated point mutants of FGFR1	5	5.85e-01	0.141000	7.49e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	3.87e-02	-0.141000	1.41e-01
Chromatin modifications during the maternal to zygotic transition (MZT)	23	2.42e-01	-0.141000	4.51e-01
Signaling by NTRK3 (TRKC)	16	3.31e-01	0.140000	5.49e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	2.25e-01	0.140000	4.27e-01
Metabolism of water-soluble vitamins and cofactors	115	9.72e-03	-0.140000	4.93e-02
Signaling by Hedgehog	120	8.27e-03	-0.140000	4.33e-02
FRS-mediated FGFR1 signaling	15	3.49e-01	0.140000	5.68e-01
Mitotic Anaphase	211	4.76e-04	-0.140000	4.00e-03
Phase 2 - plateau phase	11	4.25e-01	0.139000	6.32e-01
RNA Polymerase II Pre-transcription Events	77	3.50e-02	-0.139000	1.30e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	4.05e-01	0.139000	6.15e-01
Processing of Capped Intron-Containing Pre-mRNA	279	6.94e-05	-0.138000	7.49e-04
Activation of Ca-permeable Kainate Receptor	9	4.72e-01	0.138000	6.73e-01
Ionotropic activity of kainate receptors	9	4.72e-01	0.138000	6.73e-01
Signalling to ERKs	32	1.77e-01	0.138000	3.72e-01
TNFR1-induced proapoptotic signaling	24	2.44e-01	0.137000	4.53e-01
Drug ADME	59	6.81e-02	-0.137000	2.03e-01
Interferon gamma signaling	90	2.43e-02	0.137000	9.92e-02
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	4.76e-01	-0.137000	6.74e-01
Circadian Clock	67	5.26e-02	0.137000	1.71e-01
mRNA Splicing	211	6.16e-04	-0.137000	4.98e-03
Potential therapeutics for SARS	149	4.00e-03	-0.137000	2.36e-02
TCF dependent signaling in response to WNT	153	3.63e-03	-0.136000	2.20e-02
Signaling by FGFR2	61	6.64e-02	-0.136000	1.98e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.98e-01	-0.136000	3.95e-01
Nucleotide salvage	21	2.82e-01	-0.136000	4.91e-01
FGFR1c ligand binding and activation	8	5.07e-01	0.136000	7.00e-01
Fatty acid metabolism	155	3.59e-03	-0.136000	2.19e-02
Transport of the SLBP independent Mature mRNA	35	1.66e-01	-0.135000	3.63e-01
ER to Golgi Anterograde Transport	145	5.08e-03	-0.135000	2.89e-02
Separation of Sister Chromatids	168	2.63e-03	-0.135000	1.69e-02
GABA synthesis, release, reuptake and degradation	12	4.20e-01	-0.134000	6.29e-01
Nervous system development	478	4.92e-07	-0.134000	9.24e-06
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	3.85e-01	-0.134000	5.98e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	3.85e-01	-0.134000	5.98e-01
Axon guidance	459	8.74e-07	-0.134000	1.54e-05
Incretin synthesis, secretion, and inactivation	14	3.86e-01	-0.134000	5.98e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	3.86e-01	-0.134000	5.98e-01
Bile acid and bile salt metabolism	31	1.97e-01	0.134000	3.95e-01
HSF1-dependent transactivation	30	2.09e-01	-0.133000	4.11e-01
Activation of the AP-1 family of transcription factors	10	4.68e-01	0.133000	6.72e-01
VxPx cargo-targeting to cilium	19	3.17e-01	0.133000	5.33e-01
Glycolysis	68	5.89e-02	-0.132000	1.83e-01
IRS-related events triggered by IGF1R	37	1.64e-01	0.132000	3.60e-01
Transport and synthesis of PAPS	6	5.75e-01	-0.132000	7.45e-01
Amino acids regulate mTORC1	48	1.14e-01	-0.132000	2.87e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	3.19e-01	-0.132000	5.36e-01
DAG and IP3 signaling	34	1.83e-01	0.132000	3.77e-01
Transcription of E2F targets under negative control by DREAM complex	19	3.20e-01	-0.132000	5.36e-01
Regulation of PTEN gene transcription	59	8.04e-02	-0.132000	2.27e-01
Propionyl-CoA catabolism	5	6.13e-01	-0.131000	7.71e-01
Thrombin signalling through proteinase activated receptors (PARs)	27	2.41e-01	0.130000	4.49e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	3.99e-01	-0.130000	6.11e-01
Estrogen biosynthesis	5	6.15e-01	-0.130000	7.71e-01
Protein ubiquitination	71	5.85e-02	-0.130000	1.82e-01
Activation of kainate receptors upon glutamate binding	26	2.52e-01	0.130000	4.60e-01
O-glycosylation of TSR domain-containing proteins	28	2.37e-01	0.129000	4.45e-01
Golgi-to-ER retrograde transport	123	1.35e-02	-0.129000	6.46e-02
Blood group systems biosynthesis	18	3.45e-01	-0.128000	5.64e-01
Activated NTRK2 signals through RAS	6	5.86e-01	0.128000	7.49e-01
Translesion synthesis by POLI	17	3.60e-01	-0.128000	5.76e-01
DNA Double-Strand Break Repair	137	9.58e-03	-0.128000	4.88e-02
Meiotic synapsis	43	1.46e-01	-0.128000	3.35e-01
Synthesis of PG	8	5.32e-01	-0.128000	7.16e-01
AKT phosphorylates targets in the cytosol	14	4.09e-01	-0.127000	6.19e-01
Lysine catabolism	11	4.65e-01	-0.127000	6.71e-01
RIPK1-mediated regulated necrosis	31	2.20e-01	0.127000	4.20e-01
Regulation of necroptotic cell death	31	2.20e-01	0.127000	4.20e-01
G beta:gamma signalling through PI3Kgamma	22	3.02e-01	0.127000	5.14e-01
Spry regulation of FGF signaling	16	3.79e-01	-0.127000	5.93e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.52e-01	-0.127000	5.70e-01
Homology Directed Repair	110	2.23e-02	-0.126000	9.31e-02
Phospholipase C-mediated cascade; FGFR4	6	5.93e-01	0.126000	7.54e-01
SUMOylation of RNA binding proteins	47	1.35e-01	-0.126000	3.19e-01
Zygotic genome activation (ZGA)	5	6.25e-01	0.126000	7.80e-01
IKK complex recruitment mediated by RIP1	23	2.96e-01	0.126000	5.07e-01
Urea cycle	7	5.64e-01	-0.126000	7.39e-01
SUMOylation of ubiquitinylation proteins	39	1.74e-01	-0.126000	3.71e-01
SLC transporter disorders	77	5.66e-02	-0.126000	1.78e-01
STAT3 nuclear events downstream of ALK signaling	11	4.71e-01	0.125000	6.73e-01
G beta:gamma signalling through PLC beta	17	3.71e-01	0.125000	5.86e-01
Presynaptic function of Kainate receptors	17	3.71e-01	0.125000	5.86e-01
Diseases of mitotic cell cycle	38	1.83e-01	-0.125000	3.77e-01
Laminin interactions	26	2.71e-01	0.125000	4.77e-01
Neurotoxicity of clostridium toxins	9	5.17e-01	-0.125000	7.07e-01
Regulation of HMOX1 expression and activity	5	6.29e-01	0.125000	7.81e-01
Interleukin-35 Signalling	12	4.55e-01	0.125000	6.61e-01
FLT3 signaling through SRC family kinases	6	5.98e-01	-0.124000	7.59e-01
TGFBR3 regulates TGF-beta signaling	8	5.44e-01	0.124000	7.22e-01
MECP2 regulates neuronal receptors and channels	14	4.23e-01	0.124000	6.31e-01
Intrinsic Pathway of Fibrin Clot Formation	15	4.08e-01	-0.123000	6.18e-01
Muscle contraction	145	1.05e-02	0.123000	5.25e-02
Surfactant metabolism	21	3.29e-01	0.123000	5.48e-01
Signaling by Retinoic Acid	29	2.52e-01	-0.123000	4.60e-01
Hyaluronan uptake and degradation	12	4.61e-01	-0.123000	6.67e-01
PKA-mediated phosphorylation of CREB	17	3.81e-01	0.123000	5.94e-01
Regulation of PTEN localization	9	5.24e-01	-0.123000	7.13e-01
Ovarian tumor domain proteases	37	1.98e-01	0.122000	3.96e-01
Inflammasomes	21	3.35e-01	0.121000	5.52e-01
mRNA 3’-end processing	57	1.13e-01	-0.121000	2.86e-01
Signaling by FGFR3	32	2.35e-01	0.121000	4.42e-01
Macroautophagy	128	1.80e-02	-0.121000	7.99e-02
Synthesis of 5-eicosatetraenoic acids	7	5.79e-01	-0.121000	7.47e-01
Deadenylation-dependent mRNA decay	50	1.39e-01	-0.121000	3.24e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	5.80e-01	-0.121000	7.47e-01
Regulation of TLR by endogenous ligand	15	4.18e-01	0.121000	6.27e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	3.38e-01	-0.121000	5.56e-01
Intra-Golgi traffic	43	1.71e-01	0.121000	3.69e-01
Gastrulation	76	6.95e-02	-0.120000	2.06e-01
EPHB-mediated forward signaling	40	1.88e-01	0.120000	3.81e-01
Neurotransmitter receptors and postsynaptic signal transmission	141	1.38e-02	0.120000	6.50e-02
RHO GTPases Activate WASPs and WAVEs	35	2.19e-01	0.120000	4.20e-01
RAC3 GTPase cycle	88	5.15e-02	0.120000	1.68e-01
Nicotinamide salvaging	15	4.21e-01	0.120000	6.30e-01
ADORA2B mediated anti-inflammatory cytokines production	36	2.13e-01	0.120000	4.15e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	2.40e-01	-0.120000	4.49e-01
Cell Cycle Checkpoints	246	1.22e-03	-0.120000	8.90e-03
Lagging Strand Synthesis	20	3.55e-01	-0.120000	5.72e-01
NRAGE signals death through JNK	52	1.36e-01	0.120000	3.20e-01
E3 ubiquitin ligases ubiquitinate target proteins	51	1.40e-01	-0.120000	3.24e-01
Protein repair	6	6.13e-01	-0.119000	7.71e-01
SHC1 events in ERBB2 signaling	17	3.95e-01	0.119000	6.07e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	3.34e-01	0.119000	5.52e-01
Metabolism of carbohydrates	241	1.48e-03	-0.119000	1.04e-02
Synthesis of IP2, IP, and Ins in the cytosol	13	4.58e-01	0.119000	6.64e-01
Regulation of CDH11 gene transcription	5	6.46e-01	0.119000	7.90e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	6.16e-01	0.118000	7.71e-01
TGFBR1 KD Mutants in Cancer	6	6.16e-01	0.118000	7.71e-01
Antiviral mechanism by IFN-stimulated genes	140	1.59e-02	-0.118000	7.24e-02
Disease	1633	1.99e-15	-0.118000	8.53e-14
Miscellaneous transport and binding events	20	3.62e-01	-0.118000	5.78e-01
Cardiogenesis	16	4.16e-01	-0.117000	6.25e-01
WNT mediated activation of DVL	8	5.69e-01	-0.116000	7.42e-01
Programmed Cell Death	187	6.15e-03	-0.116000	3.37e-02
PKR-mediated signaling	67	1.00e-01	-0.116000	2.62e-01
FGFRL1 modulation of FGFR1 signaling	7	5.95e-01	0.116000	7.56e-01
Sodium/Proton exchangers	7	5.95e-01	0.116000	7.56e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	5.70e-01	0.116000	7.43e-01
Sialic acid metabolism	28	2.88e-01	-0.116000	4.99e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	5.72e-01	-0.115000	7.45e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	3.73e-01	0.115000	5.88e-01
Autophagy	142	1.81e-02	-0.115000	8.01e-02
Toll Like Receptor 4 (TLR4) Cascade	138	1.98e-02	0.115000	8.60e-02
CaM pathway	28	2.93e-01	0.115000	5.04e-01
Calmodulin induced events	28	2.93e-01	0.115000	5.04e-01
TRAF6 mediated NF-kB activation	23	3.41e-01	0.115000	5.59e-01
SUMOylation of SUMOylation proteins	35	2.40e-01	-0.115000	4.49e-01
Platelet Aggregation (Plug Formation)	30	2.78e-01	-0.115000	4.85e-01
Processing of Intronless Pre-mRNAs	20	3.78e-01	-0.114000	5.91e-01
IRS-mediated signalling	35	2.45e-01	0.114000	4.53e-01
Cell-cell junction organization	60	1.30e-01	0.113000	3.13e-01
IGF1R signaling cascade	38	2.29e-01	0.113000	4.33e-01
NCAM signaling for neurite out-growth	48	1.76e-01	0.113000	3.72e-01
Amine ligand-binding receptors	10	5.37e-01	0.113000	7.19e-01
Response to metal ions	6	6.33e-01	0.112000	7.82e-01
Nectin/Necl trans heterodimerization	5	6.64e-01	0.112000	8.03e-01
NOD1/2 Signaling Pathway	36	2.44e-01	0.112000	4.53e-01
Homologous DNA Pairing and Strand Exchange	43	2.05e-01	0.112000	4.05e-01
Thyroxine biosynthesis	5	6.65e-01	-0.112000	8.05e-01
Ion homeostasis	42	2.12e-01	0.111000	4.13e-01
Sema4D in semaphorin signaling	22	3.66e-01	-0.111000	5.83e-01
FGFR2 ligand binding and activation	9	5.64e-01	-0.111000	7.39e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	5.02e-02	-0.111000	1.66e-01
Interleukin-1 signaling	99	5.68e-02	-0.111000	1.78e-01
Negative regulators of DDX58/IFIH1 signaling	34	2.64e-01	0.111000	4.74e-01
Post-translational modification: synthesis of GPI-anchored proteins	59	1.43e-01	-0.110000	3.30e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	7	6.14e-01	0.110000	7.71e-01
Pyruvate metabolism	44	2.07e-01	-0.110000	4.09e-01
Vpr-mediated nuclear import of PICs	34	2.70e-01	-0.109000	4.77e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	29	3.09e-01	-0.109000	5.22e-01
Signaling by LTK	10	5.50e-01	0.109000	7.28e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	6.17e-01	0.109000	7.72e-01
SHC-mediated cascade:FGFR2	13	4.96e-01	0.109000	6.91e-01
Glucuronidation	9	5.73e-01	-0.108000	7.45e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	4.68e-01	-0.108000	6.72e-01
Nuclear signaling by ERBB4	24	3.59e-01	0.108000	5.75e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	5.35e-01	0.108000	7.18e-01
Extra-nuclear estrogen signaling	67	1.26e-01	0.108000	3.08e-01
Maturation of nucleoprotein 9683610	11	5.36e-01	0.108000	7.19e-01
RUNX3 regulates CDKN1A transcription	7	6.22e-01	-0.108000	7.77e-01
Beta-oxidation of very long chain fatty acids	11	5.37e-01	-0.108000	7.19e-01
Mucopolysaccharidoses	11	5.37e-01	-0.107000	7.19e-01
Neurotransmitter clearance	6	6.49e-01	0.107000	7.93e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	39	2.47e-01	0.107000	4.55e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.58e-01	-0.107000	6.64e-01
Defective factor IX causes hemophilia B	6	6.50e-01	-0.107000	7.95e-01
Maturation of hRSV A proteins	13	5.05e-01	-0.107000	6.99e-01
Estrogen-stimulated signaling through PRKCZ	6	6.51e-01	0.107000	7.95e-01
Maturation of protein 3a 9683673	9	5.81e-01	-0.106000	7.47e-01
Maturation of protein 3a 9694719	9	5.81e-01	-0.106000	7.47e-01
Phospholipid metabolism	183	1.33e-02	0.106000	6.40e-02
Loss of Function of TGFBR1 in Cancer	7	6.27e-01	0.106000	7.80e-01
Activation of NOXA and translocation to mitochondria	5	6.82e-01	-0.106000	8.17e-01
Vitamin C (ascorbate) metabolism	8	6.04e-01	0.106000	7.64e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	1.37e-01	0.106000	3.21e-01
Repression of WNT target genes	14	4.93e-01	0.106000	6.88e-01
Interleukin-4 and Interleukin-13 signaling	93	7.81e-02	0.106000	2.23e-01
Translesion synthesis by POLK	17	4.52e-01	-0.105000	6.59e-01
Platelet sensitization by LDL	16	4.66e-01	0.105000	6.71e-01
Nucleotide-like (purinergic) receptors	13	5.12e-01	0.105000	7.03e-01
Crosslinking of collagen fibrils	15	4.81e-01	-0.105000	6.80e-01
Heparan sulfate/heparin (HS-GAG) metabolism	40	2.50e-01	-0.105000	4.60e-01
Smooth Muscle Contraction	34	2.90e-01	-0.105000	5.01e-01
Sperm Motility And Taxes	6	6.58e-01	-0.104000	7.99e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	1.77e-01	0.104000	3.72e-01
CD28 dependent PI3K/Akt signaling	22	3.97e-01	-0.104000	6.10e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	6.34e-01	0.104000	7.82e-01
Mitotic Prophase	96	7.92e-02	-0.104000	2.24e-01
Creatine metabolism	6	6.61e-01	0.103000	8.00e-01
Metal ion SLC transporters	19	4.36e-01	-0.103000	6.43e-01
Glucagon-type ligand receptors	20	4.26e-01	0.103000	6.32e-01
Export of Viral Ribonucleoproteins from Nucleus	33	3.06e-01	-0.103000	5.19e-01
Nephron development	5	6.90e-01	-0.103000	8.23e-01
activated TAK1 mediates p38 MAPK activation	23	3.94e-01	-0.103000	6.06e-01
Signaling by FGFR	73	1.30e-01	-0.103000	3.13e-01
GP1b-IX-V activation signalling	12	5.39e-01	-0.102000	7.21e-01
TCR signaling	110	6.40e-02	-0.102000	1.92e-01
Neuronal System	276	3.47e-03	0.102000	2.15e-02
Beta-catenin independent WNT signaling	126	4.79e-02	-0.102000	1.61e-01
HDACs deacetylate histones	45	2.38e-01	-0.102000	4.45e-01
Role of ABL in ROBO-SLIT signaling	6	6.69e-01	0.101000	8.06e-01
Cyclin D associated events in G1	47	2.32e-01	-0.101000	4.37e-01
G1 Phase	47	2.32e-01	-0.101000	4.37e-01
Leishmania infection	211	1.16e-02	-0.101000	5.75e-02
Parasitic Infection Pathways	211	1.16e-02	-0.101000	5.75e-02
CDH11 homotypic and heterotypic interactions	6	6.70e-01	0.101000	8.07e-01
RUNX2 regulates bone development	26	3.77e-01	-0.100000	5.91e-01
Signal regulatory protein family interactions	13	5.32e-01	0.100000	7.16e-01
COPII-mediated vesicle transport	67	1.57e-01	-0.099900	3.52e-01
Vitamin D (calciferol) metabolism	11	5.66e-01	-0.099800	7.41e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	4.90e-01	-0.099700	6.85e-01
Thromboxane signalling through TP receptor	20	4.40e-01	0.099700	6.48e-01
Defective LFNG causes SCDO3	5	7.00e-01	-0.099600	8.30e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	5.51e-01	-0.099500	7.28e-01
alpha-linolenic acid (ALA) metabolism	12	5.51e-01	-0.099500	7.28e-01
Sema3A PAK dependent Axon repulsion	15	5.08e-01	0.098800	7.00e-01
Signaling by NOTCH2	33	3.27e-01	0.098600	5.45e-01
RUNX3 regulates p14-ARF	10	5.90e-01	0.098500	7.52e-01
Oxidative Stress Induced Senescence	77	1.35e-01	-0.098500	3.19e-01
Reduction of cytosolic Ca++ levels	9	6.10e-01	-0.098300	7.69e-01
Detoxification of Reactive Oxygen Species	30	3.52e-01	-0.098100	5.70e-01
Signaling by NOTCH	175	2.53e-02	-0.098000	1.02e-01
Keratan sulfate/keratin metabolism	28	3.69e-01	-0.098000	5.86e-01
Eicosanoid ligand-binding receptors	13	5.41e-01	-0.098000	7.21e-01
Cytoprotection by HMOX1	53	2.17e-01	-0.097900	4.20e-01
Adenylate cyclase activating pathway	8	6.31e-01	0.097900	7.82e-01
Toll-like Receptor Cascades	162	3.17e-02	0.097800	1.21e-01
Formation of the cornified envelope	36	3.10e-01	0.097700	5.24e-01
Transmission across Chemical Synapses	188	2.11e-02	0.097500	8.95e-02
OAS antiviral response	8	6.33e-01	-0.097400	7.82e-01
CDC42 GTPase cycle	141	4.60e-02	0.097300	1.56e-01
Condensation of Prometaphase Chromosomes	11	5.77e-01	0.097200	7.46e-01
Downregulation of ERBB2 signaling	24	4.11e-01	-0.097000	6.20e-01
Anchoring of the basal body to the plasma membrane	97	9.96e-02	0.096800	2.61e-01
Insulin receptor recycling	24	4.12e-01	-0.096700	6.21e-01
Digestion and absorption	7	6.58e-01	0.096600	7.99e-01
Cell Cycle, Mitotic	488	2.65e-04	-0.096400	2.37e-03
Retinoid metabolism and transport	25	4.09e-01	-0.095400	6.19e-01
G0 and Early G1	27	3.91e-01	-0.095400	6.03e-01
Post-translational protein modification	1243	1.62e-08	-0.095200	4.36e-07
RHOU GTPase cycle	40	3.03e-01	0.094200	5.15e-01
MyD88-independent TLR4 cascade	108	9.09e-02	0.094200	2.46e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	9.09e-02	0.094200	2.46e-01
Synthesis of PI	5	7.16e-01	0.093800	8.40e-01
CLEC7A (Dectin-1) signaling	86	1.34e-01	-0.093600	3.19e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	7.71e-03	-0.093400	4.10e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	4.72e-01	-0.092800	6.73e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	3.36e-01	-0.092700	5.53e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	4.52e-01	-0.092600	6.59e-01
Protein-protein interactions at synapses	61	2.11e-01	0.092600	4.13e-01
G alpha (z) signalling events	36	3.37e-01	0.092400	5.55e-01
Activated point mutants of FGFR2	7	6.73e-01	0.092200	8.09e-01
Meiosis	67	1.92e-01	-0.092200	3.87e-01
Response of Mtb to phagocytosis	22	4.55e-01	-0.092100	6.61e-01
Interleukin-9 signaling	8	6.52e-01	0.092000	7.95e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	2.62e-01	-0.091700	4.70e-01
Cell Cycle	611	1.08e-04	-0.091700	1.09e-03
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	5.53e-01	-0.091700	7.30e-01
Regulation of TP53 Degradation	35	3.48e-01	-0.091600	5.67e-01
Glucagon signaling in metabolic regulation	26	4.19e-01	0.091500	6.28e-01
Regulation of MITF-M-dependent genes involved in pigmentation	37	3.35e-01	0.091500	5.52e-01
Serotonin Neurotransmitter Release Cycle	15	5.39e-01	0.091500	7.21e-01
Carboxyterminal post-translational modifications of tubulin	34	3.56e-01	-0.091500	5.73e-01
Downregulation of ERBB2:ERBB3 signaling	12	5.84e-01	-0.091200	7.49e-01
Iron uptake and transport	52	2.57e-01	-0.090900	4.65e-01
M Phase	346	3.71e-03	-0.090800	2.22e-02
NGF-stimulated transcription	32	3.76e-01	0.090500	5.89e-01
Integration of energy metabolism	88	1.44e-01	0.090100	3.32e-01
Early Phase of HIV Life Cycle	14	5.60e-01	-0.090000	7.35e-01
Signaling by CSF3 (G-CSF)	29	4.02e-01	0.089800	6.14e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	86	1.53e-01	0.089200	3.45e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	5.02e-01	0.088900	6.96e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	5.94e-01	0.088900	7.56e-01
Synthesis of very long-chain fatty acyl-CoAs	22	4.72e-01	0.088600	6.73e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	1.12e-01	0.088500	2.85e-01
Toll Like Receptor TLR6:TLR2 Cascade	108	1.12e-01	0.088500	2.85e-01
G alpha (q) signalling events	139	7.28e-02	0.088100	2.14e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	5.07e-01	0.088000	7.00e-01
TRP channels	22	4.76e-01	0.087900	6.74e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	3.63e-01	0.087500	5.80e-01
MAP2K and MAPK activation	36	3.64e-01	-0.087500	5.80e-01
Regulation of signaling by NODAL	6	7.11e-01	-0.087500	8.37e-01
Toll Like Receptor 2 (TLR2) Cascade	109	1.15e-01	0.087400	2.88e-01
Toll Like Receptor TLR1:TLR2 Cascade	109	1.15e-01	0.087400	2.88e-01
Termination of translesion DNA synthesis	32	3.95e-01	-0.087000	6.07e-01
RHOBTB1 GTPase cycle	23	4.71e-01	0.086900	6.73e-01
COPI-independent Golgi-to-ER retrograde traffic	45	3.13e-01	-0.086900	5.27e-01
PI3K Cascade	31	4.03e-01	0.086700	6.14e-01
Signaling by SCF-KIT	40	3.44e-01	0.086500	5.61e-01
Transcriptional regulation by RUNX1	170	5.18e-02	-0.086500	1.68e-01
Protein lipoylation	10	6.36e-01	-0.086400	7.82e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	6.37e-01	-0.086200	7.83e-01
Transcriptional Regulation by TP53	346	5.96e-03	-0.086000	3.28e-02
RHOT2 GTPase cycle	7	6.94e-01	-0.085800	8.26e-01
Signaling by RNF43 mutants	7	6.95e-01	0.085700	8.26e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	3.62e-01	-0.085500	5.78e-01
Phosphorylation of CD3 and TCR zeta chains	27	4.42e-01	-0.085500	6.49e-01
Metalloprotease DUBs	20	5.09e-01	0.085400	7.00e-01
Nephrin family interactions	20	5.09e-01	0.085300	7.00e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	6.26e-01	0.084900	7.80e-01
Phase I - Functionalization of compounds	70	2.20e-01	0.084800	4.20e-01
Attachment and Entry 9694614	14	5.84e-01	0.084600	7.49e-01
NS1 Mediated Effects on Host Pathways	40	3.56e-01	-0.084400	5.73e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	4.65e-01	-0.084400	6.71e-01
MET activates PTK2 signaling	23	4.84e-01	-0.084300	6.80e-01
Toll Like Receptor 9 (TLR9) Cascade	108	1.31e-01	0.084200	3.14e-01
Glycosphingolipid metabolism	46	3.24e-01	-0.084100	5.41e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	4.95e-01	-0.084000	6.90e-01
G2 Phase	5	7.46e-01	-0.083500	8.61e-01
VEGFR2 mediated cell proliferation	18	5.40e-01	0.083400	7.21e-01
PI3K/AKT Signaling in Cancer	85	1.84e-01	0.083300	3.79e-01
Initiation of Nuclear Envelope (NE) Reformation	19	5.31e-01	-0.083100	7.16e-01
MECP2 regulates transcription of neuronal ligands	5	7.48e-01	-0.083100	8.62e-01
Keratinization	37	3.83e-01	0.082900	5.96e-01
RHO GTPases activate IQGAPs	25	4.74e-01	-0.082700	6.73e-01
Triglyceride metabolism	26	4.66e-01	0.082700	6.71e-01
Regulation of TNFR1 signaling	47	3.28e-01	0.082500	5.46e-01
Elastic fibre formation	33	4.13e-01	-0.082300	6.22e-01
Hemostasis	562	8.48e-04	-0.082300	6.55e-03
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	5.29e-01	-0.081300	7.15e-01
Class I MHC mediated antigen processing & presentation	344	9.61e-03	-0.081200	4.89e-02
p38MAPK events	13	6.13e-01	-0.081000	7.71e-01
PECAM1 interactions	12	6.28e-01	0.080900	7.80e-01
SHC-mediated cascade:FGFR1	13	6.14e-01	0.080900	7.71e-01
RSK activation	7	7.11e-01	0.080800	8.37e-01
Cell junction organization	82	2.07e-01	0.080700	4.09e-01
VEGFR2 mediated vascular permeability	26	4.77e-01	-0.080600	6.74e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	7.55e-01	-0.080600	8.66e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	7.55e-01	-0.080600	8.66e-01
Cell-Cell communication	114	1.38e-01	0.080500	3.21e-01
TNFR1-induced NF-kappa-B signaling pathway	32	4.31e-01	0.080500	6.38e-01
Integrin signaling	22	5.14e-01	-0.080400	7.05e-01
RUNX3 regulates WNT signaling	8	6.95e-01	0.080000	8.26e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	4.35e-01	-0.079800	6.42e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	4.35e-01	-0.079800	6.42e-01
Transport of small molecules	558	1.26e-03	-0.079800	9.15e-03
SUMOylation of chromatin organization proteins	57	3.00e-01	-0.079400	5.13e-01
Deadenylation of mRNA	22	5.19e-01	0.079300	7.09e-01
SLC-mediated transmembrane transport	175	7.06e-02	-0.079200	2.08e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	1.72e-01	0.079000	3.69e-01
MITF-M-dependent gene expression	83	2.14e-01	0.079000	4.15e-01
Carnitine shuttle	12	6.36e-01	-0.078900	7.82e-01
Kidney development	17	5.75e-01	-0.078600	7.45e-01
Death Receptor Signaling	145	1.03e-01	0.078500	2.67e-01
Alpha-protein kinase 1 signaling pathway	11	6.52e-01	0.078500	7.95e-01
Generation of second messenger molecules	38	4.05e-01	-0.078000	6.15e-01
Cargo recognition for clathrin-mediated endocytosis	89	2.05e-01	-0.077800	4.05e-01
Methylation	13	6.27e-01	-0.077800	7.80e-01
Vesicle-mediated transport	669	6.14e-04	-0.077600	4.98e-03
Interleukin-1 family signaling	127	1.31e-01	-0.077600	3.14e-01
IRAK2 mediated activation of TAK1 complex	10	6.73e-01	-0.077100	8.09e-01
Inactivation of CDC42 and RAC1	7	7.24e-01	-0.077100	8.47e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	4.50e-01	-0.077100	6.58e-01
TNF signaling	56	3.19e-01	0.077000	5.35e-01
Trafficking and processing of endosomal TLR	13	6.31e-01	-0.076900	7.82e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	6.06e-01	0.076900	7.66e-01
SARS-CoV-2 modulates autophagy	11	6.59e-01	-0.076800	7.99e-01
MyD88 dependent cascade initiated on endosome	101	1.83e-01	0.076600	3.77e-01
Interleukin-23 signaling	7	7.26e-01	0.076500	8.47e-01
Molecules associated with elastic fibres	26	5.03e-01	-0.076000	6.96e-01
Formation of the ureteric bud	5	7.69e-01	-0.075700	8.77e-01
Synthesis of PIPs at the Golgi membrane	16	6.00e-01	-0.075700	7.60e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	4.82e-01	-0.075400	6.80e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	4.83e-01	-0.075300	6.80e-01
RA biosynthesis pathway	13	6.39e-01	-0.075200	7.84e-01
ISG15 antiviral mechanism	72	2.71e-01	-0.075000	4.77e-01
O-linked glycosylation of mucins	47	3.73e-01	-0.075000	5.88e-01
Nuclear Receptor transcription pathway	40	4.12e-01	0.075000	6.21e-01
Activation of NMDA receptors and postsynaptic events	74	2.65e-01	0.074900	4.75e-01
Signaling by EGFR	48	3.70e-01	0.074800	5.86e-01
Glycogen synthesis	11	6.68e-01	-0.074700	8.06e-01
Synthesis of IP3 and IP4 in the cytosol	22	5.44e-01	0.074700	7.22e-01
Regulation of TP53 Expression and Degradation	36	4.39e-01	-0.074600	6.46e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	1.88e-01	0.074400	3.81e-01
HDR through MMEJ (alt-NHEJ)	12	6.57e-01	0.074100	7.99e-01
Chondroitin sulfate/dermatan sulfate metabolism	38	4.30e-01	-0.074000	6.38e-01
Transcriptional regulation of testis differentiation	5	7.76e-01	-0.073400	8.81e-01
Effects of PIP2 hydrolysis	24	5.35e-01	-0.073200	7.18e-01
Sphingolipid de novo biosynthesis	34	4.61e-01	-0.073000	6.67e-01
Signaling by high-kinase activity BRAF mutants	33	4.68e-01	-0.072900	6.72e-01
Sensory perception of taste	22	5.56e-01	0.072600	7.32e-01
RHO GTPase cycle	412	1.19e-02	0.072300	5.81e-02
Ub-specific processing proteases	153	1.24e-01	-0.072000	3.06e-01
Collagen chain trimerization	29	5.02e-01	0.072000	6.96e-01
Toll Like Receptor 3 (TLR3) Cascade	104	2.04e-01	0.072000	4.05e-01
Keratan sulfate degradation	9	7.08e-01	-0.072000	8.35e-01
Negative regulation of the PI3K/AKT network	93	2.32e-01	0.071800	4.37e-01
Signaling by FGFR4	32	4.84e-01	0.071500	6.80e-01
RHO GTPases Activate Formins	128	1.63e-01	-0.071500	3.58e-01
Extracellular matrix organization	222	6.68e-02	-0.071400	1.99e-01
Biosynthesis of EPA-derived SPMs	6	7.62e-01	-0.071400	8.71e-01
Diseases of DNA repair	51	3.81e-01	0.071000	5.93e-01
Signaling by NODAL	15	6.35e-01	0.070700	7.82e-01
RAB GEFs exchange GTP for GDP on RABs	89	2.50e-01	0.070600	4.59e-01
Activation of RAC1	11	6.85e-01	0.070600	8.20e-01
Nuclear Pore Complex (NPC) Disassembly	36	4.66e-01	-0.070200	6.71e-01
Beta-catenin phosphorylation cascade	17	6.16e-01	0.070200	7.71e-01
Glycosaminoglycan metabolism	98	2.32e-01	-0.069900	4.37e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	7.49e-01	0.069800	8.63e-01
RND3 GTPase cycle	36	4.70e-01	0.069600	6.73e-01
Collagen degradation	44	4.25e-01	0.069500	6.32e-01
Neurexins and neuroligins	40	4.48e-01	0.069400	6.55e-01
Dissolution of Fibrin Clot	12	6.78e-01	0.069100	8.15e-01
RUNX2 regulates osteoblast differentiation	21	5.85e-01	-0.068800	7.49e-01
Vitamin B5 (pantothenate) metabolism	20	5.96e-01	-0.068500	7.56e-01
Glycogen metabolism	21	5.90e-01	0.067900	7.52e-01
MyD88 cascade initiated on plasma membrane	95	2.54e-01	0.067700	4.62e-01
Toll Like Receptor 10 (TLR10) Cascade	95	2.54e-01	0.067700	4.62e-01
Toll Like Receptor 5 (TLR5) Cascade	95	2.54e-01	0.067700	4.62e-01
Diseases associated with O-glycosylation of proteins	50	4.08e-01	-0.067700	6.18e-01
Synthesis of PC	23	5.75e-01	0.067500	7.45e-01
Deactivation of the beta-catenin transactivating complex	36	4.86e-01	-0.067100	6.82e-01
RUNX1 regulates expression of components of tight junctions	5	7.96e-01	0.066900	8.92e-01
Interleukin-12 family signaling	53	4.03e-01	-0.066300	6.14e-01
RET signaling	32	5.17e-01	0.066200	7.07e-01
FGFR1 ligand binding and activation	10	7.18e-01	0.066000	8.41e-01
RND2 GTPase cycle	37	4.88e-01	-0.065900	6.83e-01
The canonical retinoid cycle in rods (twilight vision)	9	7.32e-01	-0.065900	8.50e-01
Antimicrobial peptides	34	5.07e-01	-0.065700	7.00e-01
CD28 dependent Vav1 pathway	12	6.94e-01	0.065600	8.26e-01
NR1H2 and NR1H3-mediated signaling	39	4.79e-01	0.065500	6.77e-01
Sphingolipid metabolism	91	2.82e-01	-0.065300	4.91e-01
Post NMDA receptor activation events	64	3.68e-01	0.065100	5.84e-01
RHO GTPases Activate NADPH Oxidases	21	6.07e-01	0.064900	7.66e-01
Ion channel transport	141	1.83e-01	0.064900	3.77e-01
CS/DS degradation	9	7.37e-01	-0.064700	8.53e-01
Syndecan interactions	26	5.69e-01	-0.064600	7.42e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	6.36e-01	0.064500	7.82e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	6.36e-01	0.064500	7.82e-01
HATs acetylate histones	92	2.85e-01	-0.064500	4.95e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	7.12e-01	-0.064400	8.37e-01
Noncanonical activation of NOTCH3	8	7.53e-01	-0.064200	8.65e-01
Aquaporin-mediated transport	38	4.96e-01	0.063800	6.90e-01
Cellular Senescence	143	1.90e-01	-0.063500	3.83e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	8.06e-01	0.063300	8.99e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	6.09e-01	0.062900	7.69e-01
PPARA activates gene expression	105	2.66e-01	0.062800	4.76e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	7.91e-01	-0.062600	8.89e-01
Metabolism of steroid hormones	22	6.12e-01	-0.062500	7.71e-01
MHC class II antigen presentation	113	2.53e-01	-0.062200	4.61e-01
Signaling by NTRK1 (TRKA)	102	2.79e-01	0.062000	4.87e-01
Signaling by FGFR1	42	4.87e-01	0.062000	6.83e-01
Apoptotic execution phase	46	4.68e-01	0.061800	6.72e-01
Regulation of lipid metabolism by PPARalpha	107	2.71e-01	0.061600	4.77e-01
Negative regulation of FLT3	15	6.80e-01	-0.061500	8.16e-01
MTOR signalling	39	5.08e-01	-0.061300	7.00e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	6.72e-01	0.061200	8.09e-01
Keratan sulfate biosynthesis	20	6.37e-01	-0.060900	7.83e-01
AMPK inhibits chREBP transcriptional activation activity	6	7.97e-01	0.060700	8.93e-01
NCAM1 interactions	27	5.86e-01	0.060600	7.49e-01
Assembly and cell surface presentation of NMDA receptors	34	5.41e-01	0.060500	7.21e-01
Signaling by BMP	23	6.16e-01	0.060500	7.71e-01
Insulin receptor signalling cascade	40	5.08e-01	0.060500	7.00e-01
TGF-beta receptor signaling activates SMADs	45	4.86e-01	-0.060100	6.82e-01
Biological oxidations	146	2.13e-01	-0.059700	4.15e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	5.66e-01	0.059600	7.40e-01
Uptake and actions of bacterial toxins	28	5.86e-01	0.059400	7.49e-01
Phase 4 - resting membrane potential	9	7.58e-01	0.059300	8.69e-01
L1CAM interactions	100	3.06e-01	0.059300	5.18e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	1.60e-01	-0.059000	3.55e-01
Signaling by NTRKs	117	2.71e-01	0.058900	4.77e-01
Class B/2 (Secretin family receptors)	55	4.52e-01	0.058700	6.59e-01
Glycerophospholipid biosynthesis	105	3.00e-01	0.058600	5.13e-01
Signaling by TGFB family members	139	2.33e-01	0.058500	4.39e-01
WNT ligand biogenesis and trafficking	19	6.59e-01	0.058500	7.99e-01
Recycling pathway of L1	40	5.23e-01	-0.058400	7.12e-01
Clathrin-mediated endocytosis	128	2.59e-01	-0.057800	4.68e-01
PKA activation	15	7.00e-01	0.057500	8.30e-01
Signaling by WNT	241	1.24e-01	-0.057500	3.06e-01
A tetrasaccharide linker sequence is required for GAG synthesis	17	6.84e-01	-0.056900	8.19e-01
ER Quality Control Compartment (ERQC)	21	6.53e-01	-0.056700	7.96e-01
Defensins	8	7.83e-01	-0.056300	8.85e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	7.16e-01	-0.056200	8.40e-01
Pre-NOTCH Processing in Golgi	18	6.81e-01	-0.056100	8.16e-01
VEGFA-VEGFR2 Pathway	93	3.51e-01	0.056000	5.69e-01
Netrin-1 signaling	35	5.67e-01	0.055900	7.41e-01
Developmental Biology	929	4.02e-03	-0.055700	2.36e-02
Vasopressin regulates renal water homeostasis via Aquaporins	34	5.75e-01	0.055500	7.45e-01
Ethanol oxidation	8	7.87e-01	-0.055300	8.88e-01
Neurotransmitter release cycle	38	5.56e-01	0.055200	7.32e-01
Recruitment of NuMA to mitotic centrosomes	88	3.70e-01	-0.055200	5.86e-01
Formation of Fibrin Clot (Clotting Cascade)	26	6.27e-01	-0.055000	7.80e-01
Hyaluronan metabolism	16	7.04e-01	-0.055000	8.32e-01
Diseases associated with glycosaminoglycan metabolism	25	6.35e-01	-0.054900	7.82e-01
Telomere C-strand (Lagging Strand) Synthesis	34	5.80e-01	-0.054900	7.47e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	19	6.79e-01	0.054900	8.15e-01
Transcriptional regulation of granulopoiesis	44	5.31e-01	-0.054600	7.16e-01
GPCR downstream signalling	398	6.18e-02	0.054500	1.90e-01
Nuclear Events (kinase and transcription factor activation)	54	4.90e-01	0.054300	6.85e-01
Coenzyme A biosynthesis	7	8.05e-01	-0.054000	8.98e-01
Platelet activation, signaling and aggregation	223	1.67e-01	-0.053700	3.64e-01
Cytosolic sensors of pathogen-associated DNA	63	4.61e-01	-0.053700	6.67e-01
DNA Damage Bypass	47	5.26e-01	-0.053500	7.14e-01
Adaptive Immune System	768	1.17e-02	-0.053500	5.75e-02
HDR through Homologous Recombination (HRR)	68	4.46e-01	-0.053400	6.54e-01
Sensory processing of sound by outer hair cells of the cochlea	41	5.54e-01	-0.053400	7.31e-01
Inositol phosphate metabolism	42	5.50e-01	0.053400	7.28e-01
RNA polymerase II transcribes snRNA genes	71	4.39e-01	-0.053200	6.46e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	6.90e-01	0.052900	8.23e-01
RHOBTB GTPase Cycle	35	5.90e-01	0.052600	7.52e-01
Activation of SMO	13	7.43e-01	0.052500	8.59e-01
Formation of WDR5-containing histone-modifying complexes	42	5.56e-01	-0.052500	7.32e-01
SUMOylation of intracellular receptors	26	6.44e-01	0.052300	7.89e-01
Regulation of KIT signaling	15	7.26e-01	0.052300	8.47e-01
RHOG GTPase cycle	71	4.46e-01	0.052300	6.54e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	81	4.18e-01	-0.052100	6.27e-01
Transport of bile salts and organic acids, metal ions and amine compounds	52	5.17e-01	0.052000	7.07e-01
HS-GAG biosynthesis	20	6.87e-01	-0.052000	8.21e-01
Signaling by NOTCH3	44	5.52e-01	-0.051800	7.30e-01
STING mediated induction of host immune responses	15	7.30e-01	0.051500	8.49e-01
Prostacyclin signalling through prostacyclin receptor	16	7.22e-01	0.051300	8.46e-01
Sema4D induced cell migration and growth-cone collapse	19	7.00e-01	-0.051000	8.30e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	7.60e-01	0.050900	8.69e-01
Signaling by TGF-beta Receptor Complex	91	4.04e-01	0.050700	6.14e-01
Signaling by FGFR in disease	52	5.28e-01	0.050500	7.15e-01
Nonhomologous End-Joining (NHEJ)	40	5.81e-01	-0.050400	7.47e-01
Transcriptional activation of mitochondrial biogenesis	52	5.30e-01	0.050300	7.16e-01
Cell death signalling via NRAGE, NRIF and NADE	69	4.76e-01	0.049600	6.74e-01
Synthesis of UDP-N-acetyl-glucosamine	8	8.08e-01	-0.049500	8.99e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	79	4.47e-01	-0.049500	6.55e-01
Fertilization	12	7.67e-01	0.049400	8.76e-01
Formation of the beta-catenin:TCF transactivating complex	44	5.71e-01	-0.049400	7.44e-01
FasL/ CD95L signaling	5	8.49e-01	0.049300	9.24e-01
Signaling by Non-Receptor Tyrosine Kinases	47	5.60e-01	0.049100	7.35e-01
Signaling by PTK6	47	5.60e-01	0.049100	7.35e-01
MITF-M-regulated melanocyte development	113	3.67e-01	0.049100	5.84e-01
Regulation of TP53 Activity	153	2.95e-01	-0.049000	5.07e-01
RHO GTPases activate PAKs	20	7.06e-01	-0.048700	8.35e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	7.90e-01	0.048700	8.89e-01
PIP3 activates AKT signaling	235	1.99e-01	-0.048600	3.97e-01
Mitochondrial unfolded protein response (UPRmt)	17	7.29e-01	-0.048500	8.49e-01
Nuclear Envelope Breakdown	53	5.43e-01	-0.048200	7.22e-01
CD163 mediating an anti-inflammatory response	9	8.03e-01	0.048100	8.97e-01
Signaling by FGFR2 in disease	33	6.34e-01	-0.047900	7.82e-01
Netrin mediated repulsion signals	5	8.53e-01	0.047900	9.24e-01
Biosynthesis of specialized proresolving mediators (SPMs)	17	7.33e-01	0.047900	8.51e-01
Downstream signal transduction	27	6.68e-01	0.047700	8.06e-01
Phospholipase C-mediated cascade; FGFR2	8	8.16e-01	0.047600	9.03e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	6.81e-01	-0.047500	8.16e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	7.68e-01	0.047300	8.76e-01
Synaptic adhesion-like molecules	17	7.36e-01	0.047200	8.53e-01
Costimulation by the CD28 family	74	4.83e-01	-0.047200	6.80e-01
Sensory Perception	197	2.54e-01	0.047100	4.62e-01
Semaphorin interactions	56	5.42e-01	0.047100	7.22e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	7.45e-01	0.047000	8.60e-01
Chondroitin sulfate biosynthesis	12	7.78e-01	0.046900	8.82e-01
Sodium/Calcium exchangers	9	8.08e-01	-0.046900	8.99e-01
Branched-chain ketoacid dehydrogenase kinase deficiency	5	8.56e-01	0.046800	9.27e-01
Dectin-2 family	19	7.24e-01	-0.046700	8.47e-01
FOXO-mediated transcription	58	5.38e-01	0.046700	7.20e-01
Cilium Assembly	186	2.75e-01	0.046400	4.81e-01
STAT5 Activation	7	8.32e-01	0.046400	9.15e-01
Anchoring fibril formation	10	8.00e-01	-0.046400	8.94e-01
RHOQ GTPase cycle	55	5.53e-01	-0.046300	7.30e-01
Intraflagellar transport	47	5.84e-01	0.046200	7.49e-01
Activation of Matrix Metalloproteinases	22	7.09e-01	-0.046000	8.35e-01
Signaling by NOTCH1	68	5.13e-01	0.045900	7.04e-01
Passive transport by Aquaporins	6	8.46e-01	0.045900	9.23e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	3.93e-01	-0.045700	6.06e-01
G2/M DNA damage checkpoint	66	5.23e-01	-0.045400	7.12e-01
Trafficking of GluR2-containing AMPA receptors	11	7.94e-01	-0.045400	8.92e-01
TNFs bind their physiological receptors	25	6.96e-01	0.045100	8.27e-01
Interleukin-37 signaling	19	7.36e-01	-0.044700	8.53e-01
Interleukin-17 signaling	68	5.26e-01	0.044500	7.14e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	7.98e-01	-0.044500	8.94e-01
Synthesis of PE	12	7.90e-01	-0.044500	8.89e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	6.54e-01	0.044400	7.96e-01
Tight junction interactions	17	7.52e-01	-0.044300	8.65e-01
Regulation of TP53 Activity through Association with Co-factors	13	7.83e-01	-0.044200	8.85e-01
SUMO is proteolytically processed	6	8.52e-01	-0.044000	9.24e-01
Peptide ligand-binding receptors	101	4.45e-01	0.044000	6.52e-01
Signaling by GPCR	442	1.14e-01	0.043900	2.87e-01
Fatty acyl-CoA biosynthesis	35	6.54e-01	-0.043800	7.96e-01
RHOD GTPase cycle	50	5.96e-01	-0.043300	7.56e-01
Signaling by VEGF	100	4.57e-01	0.043100	6.63e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	55	5.81e-01	-0.043000	7.47e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	55	5.81e-01	-0.043000	7.47e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	55	5.81e-01	-0.043000	7.47e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	55	5.81e-01	-0.043000	7.47e-01
Signaling by NOTCH1 in Cancer	55	5.81e-01	-0.043000	7.47e-01
Factors involved in megakaryocyte development and platelet production	129	3.99e-01	0.043000	6.11e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	7.89e-01	-0.042900	8.89e-01
RAF/MAP kinase cascade	226	2.68e-01	-0.042700	4.77e-01
Signaling by MET	68	5.43e-01	0.042700	7.22e-01
MAP kinase activation	63	5.60e-01	0.042500	7.35e-01
Maternal to zygotic transition (MZT)	72	5.34e-01	0.042400	7.18e-01
RHOA GTPase cycle	139	3.88e-01	0.042400	6.01e-01
Negative regulation of FGFR2 signaling	24	7.21e-01	-0.042100	8.45e-01
RHO GTPase Effectors	258	2.45e-01	-0.042100	4.53e-01
Platelet calcium homeostasis	22	7.34e-01	-0.041800	8.51e-01
TICAM1-dependent activation of IRF3/IRF7	13	7.95e-01	0.041600	8.92e-01
Signalling to RAS	19	7.54e-01	-0.041600	8.65e-01
IRAK1 recruits IKK complex	14	7.88e-01	-0.041500	8.89e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	7.88e-01	-0.041500	8.89e-01
Inactivation of CSF3 (G-CSF) signaling	24	7.25e-01	0.041400	8.47e-01
Metabolism of steroids	125	4.25e-01	-0.041300	6.32e-01
Induction of Cell-Cell Fusion	8	8.40e-01	-0.041200	9.21e-01
Notch-HLH transcription pathway	28	7.07e-01	0.041100	8.35e-01
cGMP effects	12	8.07e-01	0.040800	8.99e-01
Signaling by BRAF and RAF1 fusions	60	5.85e-01	0.040800	7.49e-01
Triglyceride catabolism	16	7.81e-01	-0.040200	8.84e-01
FOXO-mediated transcription of cell death genes	16	7.81e-01	-0.040200	8.84e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	5.27e-01	-0.039700	7.14e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	5.27e-01	-0.039700	7.14e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	5.27e-01	-0.039700	7.14e-01
Kinesins	51	6.24e-01	-0.039700	7.78e-01
Advanced glycosylation endproduct receptor signaling	12	8.12e-01	0.039600	9.01e-01
ESR-mediated signaling	160	3.89e-01	0.039400	6.02e-01
Processing of DNA double-strand break ends	69	5.71e-01	-0.039400	7.44e-01
Downregulation of TGF-beta receptor signaling	26	7.31e-01	-0.039000	8.49e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	8.69e-01	-0.038700	9.35e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	7.28e-01	0.038600	8.49e-01
Sphingolipid catabolism	11	8.25e-01	0.038500	9.12e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	8.42e-01	0.038300	9.21e-01
Regulation of endogenous retroelements	92	5.26e-01	-0.038200	7.14e-01
O-linked glycosylation	85	5.44e-01	-0.038100	7.22e-01
Polymerase switching on the C-strand of the telomere	26	7.38e-01	-0.037900	8.53e-01
Other interleukin signaling	19	7.75e-01	0.037900	8.81e-01
Transcriptional regulation of white adipocyte differentiation	77	5.66e-01	0.037900	7.40e-01
Activation of AMPK downstream of NMDARs	20	7.69e-01	-0.037900	8.77e-01
mRNA Editing	8	8.54e-01	0.037600	9.25e-01
G alpha (s) signalling events	97	5.22e-01	0.037600	7.12e-01
trans-Golgi Network Vesicle Budding	69	5.90e-01	-0.037500	7.52e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	8.39e-01	0.037100	9.21e-01
MAPK1/MAPK3 signaling	232	3.31e-01	-0.037100	5.49e-01
Gene expression (Transcription)	1413	2.00e-02	-0.036900	8.63e-02
The activation of arylsulfatases	10	8.40e-01	-0.036800	9.21e-01
Early SARS-CoV-2 Infection Events	31	7.24e-01	0.036700	8.47e-01
Mitotic Spindle Checkpoint	108	5.12e-01	-0.036500	7.03e-01
C-type lectin receptors (CLRs)	118	4.94e-01	-0.036500	6.88e-01
HDL remodeling	6	8.78e-01	0.036300	9.40e-01
Signaling by PDGF	50	6.58e-01	0.036200	7.99e-01
Calcineurin activates NFAT	9	8.51e-01	-0.036100	9.24e-01
Visual phototransduction	60	6.29e-01	-0.036000	7.81e-01
RHOF GTPase cycle	39	7.00e-01	0.035600	8.30e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	6.31e-01	-0.035600	7.82e-01
Cargo trafficking to the periciliary membrane	47	6.73e-01	-0.035500	8.09e-01
Defective RIPK1-mediated regulated necrosis	7	8.71e-01	-0.035400	9.36e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	8.07e-01	-0.035300	8.99e-01
Assembly of collagen fibrils and other multimeric structures	44	6.87e-01	-0.035100	8.21e-01
Regulation of CDH19 Expression and Function	6	8.83e-01	0.034800	9.43e-01
Regulation of pyruvate metabolism	32	7.34e-01	-0.034700	8.51e-01
Interferon Signaling	240	3.54e-01	-0.034700	5.72e-01
HS-GAG degradation	19	7.94e-01	-0.034600	8.92e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	8.12e-01	0.034400	9.01e-01
Telomere C-strand synthesis initiation	13	8.30e-01	-0.034300	9.15e-01
PKMTs methylate histone lysines	44	6.94e-01	-0.034200	8.26e-01
Rab regulation of trafficking	122	5.18e-01	0.033800	7.08e-01
TGFBR3 PTM regulation	10	8.53e-01	-0.033800	9.24e-01
Chemokine receptors bind chemokines	39	7.15e-01	0.033700	8.40e-01
HDL assembly	6	8.86e-01	0.033700	9.45e-01
RHOC GTPase cycle	72	6.22e-01	0.033600	7.77e-01
Suppression of phagosomal maturation	12	8.41e-01	-0.033400	9.21e-01
Oncogenic MAPK signaling	76	6.16e-01	0.033300	7.71e-01
Stimuli-sensing channels	81	6.06e-01	0.033200	7.66e-01
Retrograde transport at the Trans-Golgi-Network	49	6.88e-01	0.033100	8.22e-01
Metabolic disorders of biological oxidation enzymes	26	7.70e-01	-0.033100	8.77e-01
Negative regulation of FGFR1 signaling	25	7.78e-01	-0.032600	8.82e-01
Interleukin-12 signaling	44	7.09e-01	-0.032600	8.35e-01
Loss of Nlp from mitotic centrosomes	69	6.41e-01	0.032500	7.86e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	6.41e-01	0.032500	7.86e-01
Arachidonate metabolism	45	7.06e-01	-0.032500	8.35e-01
Depolymerization of the Nuclear Lamina	15	8.28e-01	0.032500	9.14e-01
Post-translational protein phosphorylation	70	6.44e-01	-0.032000	7.89e-01
Organelle biogenesis and maintenance	277	3.62e-01	-0.031800	5.78e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	8.49e-01	0.031700	9.24e-01
CD28 co-stimulation	33	7.53e-01	-0.031700	8.65e-01
Phosphate bond hydrolysis by NTPDase proteins	5	9.03e-01	0.031400	9.59e-01
AKT phosphorylates targets in the nucleus	9	8.72e-01	-0.031000	9.36e-01
Pyrimidine salvage	10	8.66e-01	-0.030800	9.32e-01
RNA Polymerase II Transcription	1206	7.48e-02	-0.030500	2.16e-01
SUMOylation of transcription cofactors	44	7.31e-01	0.030000	8.49e-01
Listeria monocytogenes entry into host cells	17	8.31e-01	0.029900	9.15e-01
FLT3 Signaling	38	7.50e-01	0.029800	8.64e-01
Generic Transcription Pathway	1088	9.87e-02	-0.029600	2.60e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	38	7.52e-01	-0.029600	8.65e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	7.25e-01	-0.029300	8.47e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	8.60e-01	-0.029300	9.29e-01
RHOBTB2 GTPase cycle	23	8.09e-01	0.029200	8.99e-01
Miro GTPase Cycle	8	8.87e-01	-0.029000	9.45e-01
Negative regulation of FGFR4 signaling	22	8.15e-01	-0.028800	9.03e-01
Intracellular signaling by second messengers	268	4.17e-01	-0.028800	6.26e-01
RHO GTPases activate CIT	18	8.33e-01	-0.028700	9.16e-01
Pre-NOTCH Expression and Processing	63	6.97e-01	-0.028400	8.27e-01
SUMOylation of DNA damage response and repair proteins	77	6.68e-01	-0.028300	8.06e-01
Reproduction	85	6.57e-01	-0.027900	7.99e-01
Interferon alpha/beta signaling	64	7.03e-01	0.027500	8.32e-01
Signaling by ALK	24	8.16e-01	0.027400	9.04e-01
Defective B3GAT3 causes JDSSDHD	11	8.75e-01	0.027300	9.38e-01
EML4 and NUDC in mitotic spindle formation	107	6.28e-01	-0.027100	7.80e-01
Presynaptic depolarization and calcium channel opening	8	8.95e-01	0.026900	9.53e-01
Aspirin ADME	16	8.53e-01	-0.026800	9.24e-01
Chromatin modifying enzymes	215	4.99e-01	0.026700	6.94e-01
Chromatin organization	215	4.99e-01	0.026700	6.94e-01
Regulation of PLK1 Activity at G2/M Transition	87	6.67e-01	0.026700	8.06e-01
Tandem pore domain potassium channels	5	9.18e-01	0.026700	9.67e-01
Epigenetic regulation of gene expression	263	4.59e-01	-0.026500	6.65e-01
Interleukin-2 signaling	11	8.82e-01	-0.025800	9.43e-01
Acetylcholine Neurotransmitter Release Cycle	11	8.83e-01	0.025700	9.43e-01
Ca2+ activated K+ channels	6	9.14e-01	-0.025600	9.64e-01
Evasion by RSV of host interferon responses	20	8.46e-01	0.025100	9.23e-01
Wax and plasmalogen biosynthesis	5	9.23e-01	-0.024900	9.69e-01
PKA activation in glucagon signalling	14	8.73e-01	0.024700	9.37e-01
TYSND1 cleaves peroxisomal proteins	7	9.10e-01	-0.024600	9.61e-01
NOTCH1 Intracellular Domain Regulates Transcription	46	7.75e-01	0.024300	8.81e-01
SUMOylation of immune response proteins	12	8.85e-01	0.024000	9.45e-01
CREB3 factors activate genes	6	9.19e-01	0.023900	9.67e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	8.27e-01	-0.023900	9.13e-01
Resolution of D-Loop Structures	35	8.10e-01	0.023500	9.00e-01
Signaling by Rho GTPases	608	3.26e-01	0.023300	5.45e-01
E2F mediated regulation of DNA replication	22	8.50e-01	-0.023300	9.24e-01
The phototransduction cascade	26	8.37e-01	0.023200	9.20e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	9.00e-01	0.022800	9.57e-01
p75 NTR receptor-mediated signalling	89	7.12e-01	0.022600	8.37e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	8.89e-01	0.022400	9.47e-01
ECM proteoglycans	48	7.89e-01	-0.022400	8.89e-01
Oncogene Induced Senescence	33	8.24e-01	0.022300	9.12e-01
Acetylcholine regulates insulin secretion	9	9.08e-01	-0.022300	9.60e-01
EPH-ephrin mediated repulsion of cells	43	8.01e-01	-0.022200	8.95e-01
Biosynthesis of Lipoxins (LX)	6	9.25e-01	-0.022100	9.69e-01
Toxicity of botulinum toxin type D (botD)	5	9.33e-01	-0.021700	9.74e-01
Toxicity of botulinum toxin type F (botF)	5	9.33e-01	-0.021700	9.74e-01
Metabolism of lipids	642	3.49e-01	-0.021600	5.68e-01
RHOT1 GTPase cycle	5	9.34e-01	-0.021500	9.75e-01
Transcriptional Regulation by E2F6	34	8.31e-01	-0.021100	9.15e-01
Signal attenuation	9	9.14e-01	-0.020900	9.64e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	7.10e-01	-0.020700	8.36e-01
RHOB GTPase cycle	65	7.73e-01	0.020700	8.79e-01
CDC6 association with the ORC:origin complex	8	9.19e-01	-0.020700	9.67e-01
Signaling by ERBB2	44	8.16e-01	0.020300	9.03e-01
G alpha (i) signalling events	194	6.34e-01	0.019800	7.82e-01
RHOH GTPase cycle	34	8.42e-01	-0.019800	9.21e-01
Synthesis, secretion, and deacylation of Ghrelin	11	9.10e-01	-0.019700	9.61e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	9.28e-01	0.019600	9.72e-01
GPCR ligand binding	241	6.01e-01	0.019500	7.61e-01
Membrane Trafficking	577	4.23e-01	-0.019500	6.31e-01
Amino acid transport across the plasma membrane	26	8.65e-01	-0.019300	9.31e-01
LGI-ADAM interactions	9	9.21e-01	0.019200	9.68e-01
Signaling by Interleukins	391	5.20e-01	0.019000	7.09e-01
Nuclear events stimulated by ALK signaling in cancer	33	8.51e-01	0.018900	9.24e-01
Aryl hydrocarbon receptor signalling	6	9.36e-01	0.018800	9.76e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	9.07e-01	-0.018800	9.59e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	7.60e-01	-0.018500	8.69e-01
Amplification of signal from the kinetochores	91	7.60e-01	-0.018500	8.69e-01
TBC/RABGAPs	45	8.30e-01	-0.018500	9.15e-01
Leading Strand Synthesis	14	9.06e-01	-0.018200	9.59e-01
Polymerase switching	14	9.06e-01	-0.018200	9.59e-01
Resolution of Sister Chromatid Cohesion	116	7.37e-01	-0.018100	8.53e-01
SLC15A4:TASL-dependent IRF5 activation	6	9.40e-01	-0.017800	9.78e-01
Plasma lipoprotein assembly	10	9.24e-01	-0.017400	9.69e-01
Platelet Adhesion to exposed collagen	16	9.05e-01	-0.017300	9.59e-01
Regulation of TP53 Activity through Phosphorylation	88	7.80e-01	-0.017200	8.84e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	8.49e-01	-0.017200	9.24e-01
Signaling by RAS mutants	41	8.49e-01	-0.017200	9.24e-01
Signaling by moderate kinase activity BRAF mutants	41	8.49e-01	-0.017200	9.24e-01
Signaling downstream of RAS mutants	41	8.49e-01	-0.017200	9.24e-01
ROS and RNS production in phagocytes	30	8.71e-01	0.017100	9.36e-01
Estrogen-dependent gene expression	97	7.74e-01	0.016900	8.80e-01
RSV-host interactions	78	7.97e-01	0.016900	8.93e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	624	4.73e-01	0.016800	6.73e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	8.31e-01	-0.016600	9.15e-01
TLR3-mediated TICAM1-dependent programmed cell death	6	9.45e-01	0.016200	9.80e-01
Non-integrin membrane-ECM interactions	51	8.43e-01	0.016100	9.21e-01
Innate Immune System	971	4.01e-01	-0.015900	6.13e-01
Neurofascin interactions	5	9.52e-01	-0.015700	9.80e-01
EPH-Ephrin signaling	81	8.08e-01	0.015600	8.99e-01
Constitutive Signaling by Overexpressed ERBB2	11	9.29e-01	-0.015500	9.72e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	8.39e-01	-0.015300	9.21e-01
Degradation of the extracellular matrix	99	7.94e-01	0.015200	8.92e-01
Endosomal/Vacuolar pathway	12	9.30e-01	-0.014700	9.72e-01
Transport of fatty acids	5	9.55e-01	-0.014600	9.81e-01
MET promotes cell motility	33	8.87e-01	0.014300	9.45e-01
Signaling by Insulin receptor	63	8.45e-01	0.014200	9.23e-01
Cell-extracellular matrix interactions	16	9.23e-01	-0.014000	9.69e-01
Transcriptional Regulation by VENTX	39	8.80e-01	-0.014000	9.42e-01
Regulated Necrosis	56	8.62e-01	-0.013400	9.29e-01
EPHA-mediated growth cone collapse	21	9.17e-01	-0.013100	9.67e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	8.59e-01	0.013100	9.28e-01
Glycine degradation	7	9.54e-01	-0.012700	9.81e-01
DCC mediated attractive signaling	13	9.37e-01	-0.012600	9.76e-01
Regulated proteolysis of p75NTR	11	9.42e-01	-0.012600	9.79e-01
Mitotic Prometaphase	193	7.64e-01	0.012500	8.72e-01
Interleukin-27 signaling	11	9.43e-01	0.012400	9.79e-01
SUMOylation	167	7.83e-01	-0.012400	8.85e-01
Integration of provirus	9	9.49e-01	-0.012300	9.80e-01
Signaling by RAF1 mutants	37	8.98e-01	0.012100	9.56e-01
RAS signaling downstream of NF1 loss-of-function variants	7	9.56e-01	0.012100	9.81e-01
IRF3-mediated induction of type I IFN	12	9.45e-01	0.011600	9.80e-01
Centrosome maturation	81	8.58e-01	-0.011500	9.27e-01
Recruitment of mitotic centrosome proteins and complexes	81	8.58e-01	-0.011500	9.27e-01
Class A/1 (Rhodopsin-like receptors)	175	8.00e-01	0.011100	8.94e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	9.54e-01	-0.011100	9.81e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	9.63e-01	0.010900	9.83e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	9.63e-01	0.010900	9.83e-01
Transferrin endocytosis and recycling	26	9.24e-01	0.010900	9.69e-01
Signaling by ALK fusions and activated point mutants	89	8.61e-01	0.010700	9.29e-01
Signaling by ALK in cancer	89	8.61e-01	0.010700	9.29e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	9.62e-01	-0.010400	9.83e-01
Signal Transduction	2058	4.36e-01	0.010400	6.43e-01
The NLRP3 inflammasome	16	9.43e-01	0.010400	9.79e-01
SARS-CoV-1 activates/modulates innate immune responses	40	9.10e-01	0.010300	9.61e-01
Disorders of Developmental Biology	12	9.51e-01	0.010200	9.80e-01
Disorders of Nervous System Development	12	9.51e-01	0.010200	9.80e-01
Loss of function of MECP2 in Rett syndrome	12	9.51e-01	0.010200	9.80e-01
Pervasive developmental disorders	12	9.51e-01	0.010200	9.80e-01
Receptor Mediated Mitophagy	11	9.55e-01	-0.009910	9.81e-01
RHOJ GTPase cycle	50	9.05e-01	0.009790	9.59e-01
Scavenging by Class A Receptors	14	9.50e-01	0.009610	9.80e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	9.61e-01	-0.009000	9.83e-01
Defective EXT2 causes exostoses 2	10	9.61e-01	-0.009000	9.83e-01
Negative regulation of MAPK pathway	42	9.20e-01	-0.008950	9.68e-01
Neutrophil degranulation	458	7.44e-01	0.008890	8.60e-01
EGFR downregulation	27	9.38e-01	-0.008700	9.76e-01
Integrin cell surface interactions	68	9.02e-01	-0.008630	9.59e-01
Cargo concentration in the ER	31	9.35e-01	-0.008530	9.75e-01
Adipogenesis	96	8.85e-01	0.008510	9.45e-01
Activation of gene expression by SREBF (SREBP)	42	9.25e-01	-0.008370	9.69e-01
AURKA Activation by TPX2	72	9.03e-01	0.008280	9.59e-01
MAPK family signaling cascades	264	8.18e-01	-0.008230	9.05e-01
ERK/MAPK targets	22	9.48e-01	-0.007970	9.80e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	9.47e-01	0.007960	9.80e-01
Biosynthesis of DHA-derived SPMs	15	9.58e-01	0.007830	9.83e-01
Nitric oxide stimulates guanylate cyclase	15	9.61e-01	-0.007330	9.83e-01
Prolactin receptor signaling	12	9.65e-01	-0.007260	9.83e-01
Type I hemidesmosome assembly	8	9.72e-01	-0.007150	9.87e-01
Transcriptional regulation of brown and beige adipocyte differentiation	24	9.52e-01	-0.007150	9.80e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	24	9.52e-01	-0.007150	9.80e-01
Respiratory Syncytial Virus Infection Pathway	99	9.04e-01	-0.007040	9.59e-01
Lipophagy	7	9.74e-01	-0.007030	9.88e-01
Pyrimidine catabolism	9	9.71e-01	-0.006890	9.87e-01
Glutamate Neurotransmitter Release Cycle	20	9.58e-01	0.006830	9.83e-01
SUMO E3 ligases SUMOylate target proteins	161	8.81e-01	-0.006810	9.43e-01
Bacterial Infection Pathways	66	9.27e-01	0.006560	9.70e-01
Deubiquitination	225	8.68e-01	-0.006420	9.34e-01
Golgi Associated Vesicle Biogenesis	55	9.36e-01	0.006280	9.76e-01
Regulation of FZD by ubiquitination	16	9.66e-01	-0.006240	9.83e-01
Diseases of signal transduction by growth factor receptors and second messengers	404	8.36e-01	0.006010	9.19e-01
Vitamin B2 (riboflavin) metabolism	6	9.80e-01	0.005900	9.92e-01
TP53 Regulates Transcription of Cell Death Genes	43	9.48e-01	0.005760	9.80e-01
Signal transduction by L1	20	9.65e-01	-0.005680	9.83e-01
CTLA4 inhibitory signaling	21	9.64e-01	-0.005680	9.83e-01
TAK1-dependent IKK and NF-kappa-B activation	43	9.52e-01	-0.005330	9.80e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	9.75e-01	0.005310	9.88e-01
Cell recruitment (pro-inflammatory response)	25	9.64e-01	-0.005190	9.83e-01
Purinergic signaling in leishmaniasis infection	25	9.64e-01	-0.005190	9.83e-01
Sensory processing of sound	58	9.46e-01	0.005140	9.80e-01
E2F-enabled inhibition of pre-replication complex formation	9	9.79e-01	0.005050	9.91e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	9.66e-01	0.004720	9.83e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	9.80e-01	0.004510	9.92e-01
Ephrin signaling	18	9.75e-01	0.004270	9.88e-01
Immune System	1841	7.62e-01	-0.004260	8.71e-01
GPER1 signaling	38	9.64e-01	0.004250	9.83e-01
Cytokine Signaling in Immune system	670	8.64e-01	0.003890	9.31e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	11	9.83e-01	-0.003800	9.92e-01
RHOV GTPase cycle	36	9.70e-01	0.003660	9.86e-01
Inactivation, recovery and regulation of the phototransduction cascade	25	9.76e-01	0.003510	9.89e-01
Glycerophospholipid catabolism	6	9.88e-01	0.003410	9.96e-01
RND1 GTPase cycle	37	9.74e-01	0.003070	9.88e-01
Synthesis of PIPs at the ER membrane	5	9.91e-01	-0.003000	9.96e-01
RAB geranylgeranylation	61	9.68e-01	-0.002990	9.85e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	9.89e-01	-0.002950	9.96e-01
Elevation of cytosolic Ca2+ levels	13	9.86e-01	-0.002730	9.96e-01
Common Pathway of Fibrin Clot Formation	13	9.88e-01	-0.002430	9.96e-01
2-LTR circle formation	7	9.92e-01	0.002290	9.96e-01
Attachment of GPI anchor to uPAR	7	9.92e-01	-0.002270	9.96e-01
Signaling by Receptor Tyrosine Kinases	449	9.41e-01	-0.002040	9.78e-01
Phospholipase C-mediated cascade: FGFR1	8	9.92e-01	0.002010	9.96e-01
STAT5 activation downstream of FLT3 ITD mutants	9	9.94e-01	-0.001540	9.96e-01
Cellular responses to mechanical stimuli	82	9.83e-01	-0.001380	9.92e-01
Response of endothelial cells to shear stress	82	9.83e-01	-0.001380	9.92e-01
Platelet homeostasis	69	9.88e-01	-0.001020	9.96e-01
DARPP-32 events	22	9.94e-01	0.000989	9.96e-01
Formation of the Editosome	6	9.97e-01	0.000970	9.98e-01
mRNA Editing: C to U Conversion	6	9.97e-01	0.000970	9.98e-01
Signaling by MAPK mutants	6	9.97e-01	-0.000803	9.98e-01
Sensory processing of sound by inner hair cells of the cochlea	54	9.93e-01	-0.000739	9.96e-01
Pre-NOTCH Transcription and Translation	47	9.93e-01	-0.000709	9.96e-01
Signaling by Nuclear Receptors	214	9.89e-01	-0.000540	9.96e-01
Negative regulation of FGFR3 signaling	21	9.98e-01	-0.000338	9.98e-01
Defective B4GALT7 causes EDS, progeroid type	11	9.99e-01	-0.000190	9.99e-01

---

Detailed Gene set reports

Arachidonate production from DAG

set	Arachidonate production from DAG
setSize	5
pANOVA	0.00155
s.dist	-0.817
p.adjustANOVA	0.0108

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ABHD12	-9727
MGLL	-9542
DAGLA	-8876
ABHD6	-8836
DAGLB	-7231

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ABHD12	-9727
MGLL	-9542
DAGLA	-8876
ABHD6	-8836
DAGLB	-7231

---

Formation of ATP by chemiosmotic coupling

set	Formation of ATP by chemiosmotic coupling
setSize	20
pANOVA	2.93e-10
s.dist	-0.814
p.adjustANOVA	8.83e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5PF	-10746
ATP5MK	-10711
ATP5MC1	-10679
ATP5MC3	-10305
ATP5F1B	-10186
ATP5MC2	-10022
ATP5MF	-9980
MT-ATP8	-9565
ATP5F1E	-9301
ATP5PO	-8788
ATP5F1A	-8780
DMAC2L	-8508
ATP5PD	-8425
ATP5ME	-8411
ATP5MG	-8402
ATP5F1D	-7509
ATP5F1C	-7214
ATP5PB	-7108
MT-ATP6	-6047
ATP5MJ	-5260

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5PF	-10746
ATP5MK	-10711
ATP5MC1	-10679
ATP5MC3	-10305
ATP5F1B	-10186
ATP5MC2	-10022
ATP5MF	-9980
MT-ATP8	-9565
ATP5F1E	-9301
ATP5PO	-8788
ATP5F1A	-8780
DMAC2L	-8508
ATP5PD	-8425
ATP5ME	-8411
ATP5MG	-8402
ATP5F1D	-7509
ATP5F1C	-7214
ATP5PB	-7108
MT-ATP6	-6047
ATP5MJ	-5260

---

MET activates PI3K/AKT signaling

set	MET activates PI3K/AKT signaling
setSize	5
pANOVA	0.00263
s.dist	0.777
p.adjustANOVA	0.0169

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GAB1	11052
HGF	10962
PIK3R1	10906
PIK3CA	9393
GRB2	1127

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GAB1	11052
HGF	10962
PIK3R1	10906
PIK3CA	9393
GRB2	1127

---

PI3K events in ERBB4 signaling

set	PI3K events in ERBB4 signaling
setSize	6
pANOVA	0.00153
s.dist	0.747
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIK3R1	10906
HBEGF	9553
PIK3CA	9393
NRG1	8788
EREG	7006
NRG4	4500

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIK3R1	10906
HBEGF	9553
PIK3CA	9393
NRG1	8788
EREG	7006
NRG4	4500

---

Malate-aspartate shuttle

set	Malate-aspartate shuttle
setSize	8
pANOVA	0.000435
s.dist	-0.718
p.adjustANOVA	0.00368

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GOT2	-9776
SLC25A11	-9456
GOT1	-9285
SLC25A22	-8753
SLC25A12	-7968
MDH2	-7876
MDH1	-6891
SLC25A13	-2010

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GOT2	-9776
SLC25A11	-9456
GOT1	-9285
SLC25A22	-8753
SLC25A12	-7968
MDH2	-7876
MDH1	-6891
SLC25A13	-2010

---

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

set	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
setSize	6
pANOVA	0.00236
s.dist	-0.717
p.adjustANOVA	0.0154

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2E	-10825
KCTD1	-10533
KCTD15	-9839
UBE2I	-9435
WWOX	-8811
SUMO1	3015

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2E	-10825
KCTD1	-10533
KCTD15	-9839
UBE2I	-9435
WWOX	-8811
SUMO1	3015

---

Synthesis of Ketone Bodies

set	Synthesis of Ketone Bodies
setSize	6
pANOVA	0.00277
s.dist	-0.705
p.adjustANOVA	0.0176

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDH1	-10326
AACS	-9411
BDH2	-8668
ACAT1	-8568
HMGCL	-5508
ACSS3	-3180

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDH1	-10326
AACS	-9411
BDH2	-8668
ACAT1	-8568
HMGCL	-5508
ACSS3	-3180

---

Purine ribonucleoside monophosphate biosynthesis

set	Purine ribonucleoside monophosphate biosynthesis
setSize	9
pANOVA	0.000305
s.dist	-0.695
p.adjustANOVA	0.00267

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PAICS	-10738
ATIC	-10499
ADSL	-9903
PFAS	-9865
GART	-8706
GMPS	-7046
IMPDH2	-6249
PPAT	-2473
IMPDH1	-1998

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PAICS	-10738
ATIC	-10499
ADSL	-9903
PFAS	-9865
GART	-8706
GMPS	-7046
IMPDH2	-6249
PPAT	-2473
IMPDH1	-1998

---

Maturation of spike protein_9683686

set	Maturation of spike protein_9683686
setSize	5
pANOVA	0.00716
s.dist	-0.694
p.adjustANOVA	0.0385

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MOGS	-9800
MGAT1	-9734
GANAB	-7941
CANX	-7344
PRKCSH	-2638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MOGS	-9800
MGAT1	-9734
GANAB	-7941
CANX	-7344
PRKCSH	-2638

---

Ketone body metabolism

set	Ketone body metabolism
setSize	8
pANOVA	0.000727
s.dist	-0.69
p.adjustANOVA	0.00578

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDH1	-10326
AACS	-9411
OXCT2	-9356
BDH2	-8668
ACAT1	-8568
HMGCL	-5508
OXCT1	-4504
ACSS3	-3180

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDH1	-10326
AACS	-9411
OXCT2	-9356
BDH2	-8668
ACAT1	-8568
HMGCL	-5508
OXCT1	-4504
ACSS3	-3180

---

Mitochondrial translation elongation

set	Mitochondrial translation elongation
setSize	90
pANOVA	1.03e-29
s.dist	-0.689
p.adjustANOVA	1.53e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
TSFM	-10558
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
TSFM	-10558
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058
MRPL3	-10050
MRPL51	-10029
MRPL9	-9996
MRPL54	-9947
MRPL40	-9883
MRPL18	-9837
MRPL21	-9781
MRPL14	-9729
MRPL43	-9664
MRPS18B	-9476
MRPL15	-9421
MRPL48	-9379
MRPL27	-9214
MRPS23	-9170
MRPS33	-9139
TUFM	-9030
MRPS26	-9013
MRPL11	-8996
MRPL2	-8922
MRPS30	-8824
MRPS27	-8817
MRPL36	-8812
MRPL24	-8789
MRPL46	-8624
AURKAIP1	-8616
MRPS14	-8605
MRPS11	-8389
MRPS34	-8343
CHCHD1	-8235
MRPS18A	-8206
MRPL41	-8198
MRPS24	-8160
MRPS17	-8141
MRPS35	-8096
MRPL23	-8083
MRPL38	-8015
MRPS10	-7994
ERAL1	-7603
MRPL32	-7456
MRPL52	-7286
MRPS36	-7283
MRPL13	-6858
MRPS5	-6803
DAP3	-6643
MRPL47	-6516
RPS12	-6437
MRPS22	-6346
MRPS9	-6109
MRPL22	-6039
MRPL28	-5910
MRPS2	-5543
MRPL39	-5494
MRPL33	-5424
MRPL30	-5402
MRPL53	-5046
OXA1L	-5023
MRPL55	-4696
MRPL10	-4693
MRPL45	-4519
MRPL19	-4442
MRPL44	-3863
MRPL58	-3372
PTCD3	-3265
MRPS6	-1409
MRPL35	2184
MRPS31	2353
GFM1	2700
MRPL42	3107
MRPL50	4502
MRPL1	8557

---

Peptide chain elongation

set	Peptide chain elongation
setSize	88
pANOVA	1.76e-28
s.dist	-0.682
p.adjustANOVA	1.7e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
EEF2	-8291
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
EEF1A1	-7133
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
RPL26	-3436
RPL26L1	-2674
RPL3L	1485
RPS4Y1	2742
RPS26	6214

---

Mitochondrial translation initiation

set	Mitochondrial translation initiation
setSize	90
pANOVA	9.6e-29
s.dist	-0.677
p.adjustANOVA	1.03e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058
MRPL3	-10050

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058
MRPL3	-10050
MRPL51	-10029
MRPL9	-9996
MRPL54	-9947
MRPL40	-9883
MRPL18	-9837
MRPL21	-9781
MRPL14	-9729
MRPL43	-9664
MRPS18B	-9476
MRPL15	-9421
MRPL48	-9379
MRPL27	-9214
MRPS23	-9170
MRPS33	-9139
MRPS26	-9013
MRPL11	-8996
MRPL2	-8922
MRPS30	-8824
MRPS27	-8817
MRPL36	-8812
MRPL24	-8789
MRPL46	-8624
AURKAIP1	-8616
MRPS14	-8605
MRPS11	-8389
MRPS34	-8343
CHCHD1	-8235
MRPS18A	-8206
MRPL41	-8198
MRPS24	-8160
MRPS17	-8141
MRPS35	-8096
MRPL23	-8083
MRPL38	-8015
MRPS10	-7994
ERAL1	-7603
MRPL32	-7456
MRPL52	-7286
MRPS36	-7283
MRPL13	-6858
MRPS5	-6803
DAP3	-6643
MRPL47	-6516
RPS12	-6437
MRPS22	-6346
MRPS9	-6109
MRPL22	-6039
MRPL28	-5910
MTFMT	-5700
MRPS2	-5543
MRPL39	-5494
MRPL33	-5424
MRPL30	-5402
MRPL53	-5046
OXA1L	-5023
MRPL55	-4696
MRPL10	-4693
MRPL45	-4519
MRPL19	-4442
MRPL44	-3863
MRPL58	-3372
PTCD3	-3265
MTIF2	-3055
MRPS6	-1409
MRPL35	2184
MRPS31	2353
MRPL42	3107
MTIF3	3693
MRPL50	4502
MRPL1	8557

---

Viral mRNA Translation

set	Viral mRNA Translation
setSize	88
pANOVA	1.72e-27
s.dist	-0.669
p.adjustANOVA	1.45e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
GRSF1	-7524
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
RPL26	-3436
RPL26L1	-2674
RPL3L	1485
RPS4Y1	2742
DNAJC3	4300
RPS26	6214

---

Cristae formation

set	Cristae formation
setSize	33
pANOVA	3.62e-11
s.dist	-0.665
p.adjustANOVA	1.13e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5PF	-10746
ATP5MK	-10711
ATP5MC1	-10679
ATP5MC3	-10305
ATP5F1B	-10186
ATP5MC2	-10022
ATP5MF	-9980
MICOS10	-9860
MICOS13	-9758
MT-ATP8	-9565
ATP5F1E	-9301
HSPA9	-9167
ATP5PO	-8788
ATP5F1A	-8780
DMAC2L	-8508
ATP5PD	-8425
ATP5ME	-8411
ATP5MG	-8402
TMEM11	-7592
CHCHD3	-7572

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5PF	-10746
ATP5MK	-10711
ATP5MC1	-10679
ATP5MC3	-10305
ATP5F1B	-10186
ATP5MC2	-10022
ATP5MF	-9980
MICOS10	-9860
MICOS13	-9758
MT-ATP8	-9565
ATP5F1E	-9301
HSPA9	-9167
ATP5PO	-8788
ATP5F1A	-8780
DMAC2L	-8508
ATP5PD	-8425
ATP5ME	-8411
ATP5MG	-8402
TMEM11	-7592
CHCHD3	-7572
ATP5F1D	-7509
ATP5F1C	-7214
ATP5PB	-7108
MTX2	-7036
DNAJC11	-6127
MT-ATP6	-6047
ATP5MJ	-5260
SAMM50	-4915
IMMT	-3991
APOOL	-484
MTX1	-219
APOO	1924
CHCHD6	4351

---

Eukaryotic Translation Elongation

set	Eukaryotic Translation Elongation
setSize	93
pANOVA	1.4e-28
s.dist	-0.664
p.adjustANOVA	1.42e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
EEF2	-8291
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
EEF1A1P5	-7861
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
RPL18	-7362
RPS6	-7352
RPS17	-7300
EEF1B2	-7268
RPS8	-7263
RPL6	-7218
EEF1A1	-7133
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
EEF1G	-6066
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
EEF1D	-4889
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
RPL26	-3436
RPL26L1	-2674
RPL3L	1485
RPS4Y1	2742
RPS26	6214
EEF1A2	7215

---

Complex III assembly

set	Complex III assembly
setSize	23
pANOVA	3.92e-08
s.dist	-0.662
p.adjustANOVA	9.46e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UQCRH	-10810
FXN	-10753
CYC1	-10536
UQCR11	-10154
UQCRQ	-10011
UQCC2	-9933
LETM1	-9324
HSPA9	-9167
UQCC1	-8460
HSCB	-8415
UQCRC2	-8046
NFS1	-8035
UQCR10	-8028
UQCRC1	-7483
BCS1L	-7442
UQCC3	-7199
UQCRB	-6659
LYRM4	-6396
UQCRFS1	-5026
ISCU	-3239

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UQCRH	-10810
FXN	-10753
CYC1	-10536
UQCR11	-10154
UQCRQ	-10011
UQCC2	-9933
LETM1	-9324
HSPA9	-9167
UQCC1	-8460
HSCB	-8415
UQCRC2	-8046
NFS1	-8035
UQCR10	-8028
UQCRC1	-7483
BCS1L	-7442
UQCC3	-7199
UQCRB	-6659
LYRM4	-6396
UQCRFS1	-5026
ISCU	-3239
TTC19	-1797
MT-CYB	-1782
LYRM7	4825

---

Mitochondrial translation termination

set	Mitochondrial translation termination
setSize	90
pANOVA	2.15e-27
s.dist	-0.66
p.adjustANOVA	1.73e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058
MRPL3	-10050

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058
MRPL3	-10050
MRPL51	-10029
MRPL9	-9996
MRPL54	-9947
MRPL40	-9883
MRPL18	-9837
MRPL21	-9781
MRPL14	-9729
MRPL43	-9664
MRPS18B	-9476
MRPL15	-9421
MRPL48	-9379
MRPL27	-9214
MRPS23	-9170
MRPS33	-9139
MRPS26	-9013
MRPL11	-8996
MRPL2	-8922
MRPS30	-8824
MRPS27	-8817
MRPL36	-8812
MRPL24	-8789
MRPL46	-8624
AURKAIP1	-8616
MRPS14	-8605
MRPS11	-8389
MRPS34	-8343
CHCHD1	-8235
MRPS18A	-8206
MRPL41	-8198
MRPS24	-8160
MRPS17	-8141
MRPS35	-8096
MRPL23	-8083
MRPL38	-8015
MRPS10	-7994
ERAL1	-7603
MRPL32	-7456
MRPL52	-7286
MRPS36	-7283
MRPL13	-6858
MRPS5	-6803
DAP3	-6643
MRPL47	-6516
RPS12	-6437
MRPS22	-6346
MRPS9	-6109
MRPL22	-6039
MRPL28	-5910
MRPS2	-5543
MRPL39	-5494
MRPL33	-5424
MRPL30	-5402
MRRF	-5314
MRPL53	-5046
OXA1L	-5023
MRPL55	-4696
MRPL10	-4693
MRPL45	-4519
MRPL19	-4442
MRPL44	-3863
MRPL58	-3372
PTCD3	-3265
MRPS6	-1409
MRPL35	2184
MRPS31	2353
MRPL42	3107
MRPL50	4502
GFM2	6932
MRPL1	8557
MTRF1L	10143

---

Eukaryotic Translation Termination

set	Eukaryotic Translation Termination
setSize	92
pANOVA	1.09e-27
s.dist	-0.657
p.adjustANOVA	1e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
TRMT112	-9102
RPS13	-9069

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
TRMT112	-9102
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
APEH	-8252
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
RPL26	-3436
RPL26L1	-2674
N6AMT1	-1581
GSPT2	-748
GSPT1	-168
ETF1	253
RPL3L	1485
RPS4Y1	2742
RPS26	6214

---

SRP-dependent cotranslational protein targeting to membrane

set	SRP-dependent cotranslational protein targeting to membrane
setSize	111
pANOVA	7.62e-33
s.dist	-0.655
p.adjustANOVA	1.64e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SRPRB	-10828
SEC61A1	-10547
RPL35A	-10314
SSR4	-10215
SEC61G	-10208
SEC61B	-10118
RPS7	-10107
DDOST	-10098
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
SEC11C	-9765
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SRPRB	-10828
SEC61A1	-10547
RPL35A	-10314
SSR4	-10215
SEC61G	-10208
SEC61B	-10118
RPS7	-10107
DDOST	-10098
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
SEC11C	-9765
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
SEC11A	-9348
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPN1	-8901
RPS9	-8898
RPN2	-8897
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
SSR3	-8498
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
SRP68	-7844
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
SSR2	-7083
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
SPCS1	-6626
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
SRP14	-6103
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
SPCS2	-5637
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
SRP72	-4844
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
SRPRA	-4136
RPL27A	-3830
RPL26	-3436
RPL26L1	-2674
SEC61A2	-2080
SRP54	-1981
SRP19	-1452
SRP9	-838
TRAM1	-32
SPCS3	940
RPL3L	1485
RPS4Y1	2742
SSR1	4910
RPS26	6214

---

Formation of a pool of free 40S subunits

set	Formation of a pool of free 40S subunits
setSize	100
pANOVA	1.88e-29
s.dist	-0.651
p.adjustANOVA	2.14e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
EIF3G	-8229
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
EIF3H	-6411
RPL22	-6398
RPL21	-6245
EIF3L	-6237
RPLP1	-6177
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
EIF3E	-3969
RPL27A	-3830
RPL26	-3436
EIF3A	-2993
EIF3F	-2893
RPL26L1	-2674
EIF3J	-1222
RPL3L	1485
RPS4Y1	2742
RPS26	6214
EIF1AX	6407

---

Selenocysteine synthesis

set	Selenocysteine synthesis
setSize	92
pANOVA	4.54e-27
s.dist	-0.649
p.adjustANOVA	3.37e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
EEFSEC	-10115
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
EEFSEC	-10115
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
SARS1	-4601
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
SEPHS2	-3520
RPL26	-3436
RPL26L1	-2674
SEPSECS	1390
RPL3L	1485
PSTK	1551
RPS4Y1	2742
SECISBP2	3596
RPS26	6214

---

SARS-CoV-1 modulates host translation machinery

set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	1.7e-11
s.dist	-0.648
p.adjustANOVA	5.46e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
RPS27	-9692
RPS29	-9493
RPS23	-9366
RPS19	-9249
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPS11	-8581
RPS3	-8338
RPS14	-8044
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPSA	-7582
RPS6	-7352
RPS17	-7300

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
RPS27	-9692
RPS29	-9493
RPS23	-9366
RPS19	-9249
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPS11	-8581
RPS3	-8338
RPS14	-8044
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPSA	-7582
RPS6	-7352
RPS17	-7300
RPS8	-7263
EEF1A1	-7133
RPS16	-6912
HNRNPA1	-6887
RPS21	-6724
RPS10	-6588
RPS12	-6437
RPS27A	-5923
RPS15A	-5860
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPS3A	-4498
RPS2	-4449
RPS4Y1	2742
RPS26	6214

---

Synthesis of GDP-mannose

set	Synthesis of GDP-mannose
setSize	6
pANOVA	0.00602
s.dist	-0.648
p.adjustANOVA	0.033

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GMPPB	-10624
PMM2	-9983
PMM1	-8496
HK1	-5801
GMPPA	-4330
MPI	-2618

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GMPPB	-10624
PMM2	-9983
PMM1	-8496
HK1	-5801
GMPPA	-4330
MPI	-2618

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	94
pANOVA	3.18e-27
s.dist	-0.644
p.adjustANOVA	2.45e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
NCBP2	-7851
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
EIF4G1	-7513
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
RPS27A	-5923
UPF1	-5913
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
RPL26	-3436
RPL26L1	-2674
GSPT2	-748
PABPC1	-591
GSPT1	-168
ETF1	253
RPL3L	1485
NCBP1	2072
RPS4Y1	2742
RPS26	6214

---

Mitochondrial translation

set	Mitochondrial translation
setSize	96
pANOVA	1.63e-27
s.dist	-0.641
p.adjustANOVA	1.44e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
TSFM	-10558
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
TSFM	-10558
MRPL37	-10545
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
MRPL20	-10240
MRPL49	-10231
MRPS15	-10213
MRPS28	-10199
MRPS25	-10192
MRPL4	-10113
MRPS18C	-10058
MRPL3	-10050
MRPL51	-10029
MRPL9	-9996
MRPL54	-9947
MRPL40	-9883
MRPL18	-9837
MRPL21	-9781
MRPL14	-9729
MRPL43	-9664
MRPS18B	-9476
MRPL15	-9421
MRPL48	-9379
MRPL27	-9214
MRPS23	-9170
MRPS33	-9139
TUFM	-9030
MRPS26	-9013
MRPL11	-8996
MRPL2	-8922
MRPS30	-8824
MRPS27	-8817
MRPL36	-8812
MRPL24	-8789
MRPL46	-8624
AURKAIP1	-8616
MRPS14	-8605
MRPS11	-8389
MRPS34	-8343
CHCHD1	-8235
MRPS18A	-8206
MRPL41	-8198
MRPS24	-8160
MRPS17	-8141
MRPS35	-8096
MRPL23	-8083
MRPL38	-8015
MRPS10	-7994
ERAL1	-7603
MRPL32	-7456
MRPL52	-7286
MRPS36	-7283
MRPL13	-6858
MRPS5	-6803
DAP3	-6643
MRPL47	-6516
RPS12	-6437
MRPS22	-6346
MRPS9	-6109
MRPL22	-6039
MRPL28	-5910
MTFMT	-5700
MRPS2	-5543
MRPL39	-5494
MRPL33	-5424
MRPL30	-5402
MRRF	-5314
MRPL53	-5046
OXA1L	-5023
MRPL55	-4696
MRPL10	-4693
MRPL45	-4519
MRPL19	-4442
MRPL44	-3863
MRPL58	-3372
PTCD3	-3265
MTIF2	-3055
MRPS6	-1409
MRPL35	2184
MRPS31	2353
GFM1	2700
MRPL42	3107
MTIF3	3693
MRPL50	4502
GFM2	6932
MRPL1	8557
MTRF1L	10143

---

Mitochondrial protein import

set	Mitochondrial protein import
setSize	63
pANOVA	1.71e-18
s.dist	-0.639
p.adjustANOVA	8.24e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COA6	-10815
FXN	-10753
TIMM44	-10695
ATP5MC1	-10679
TIMM22	-10616
CYC1	-10536
TOMM5	-10516
TOMM22	-10381
CHCHD4	-10295
ATP5F1B	-10186
TOMM6	-10163
TIMM8A	-9973
TIMM8B	-9925
GFER	-9639
TIMM23	-9624
TOMM40	-9328
TIMM17A	-9310
VDAC1	-9241
HSPA9	-9167
COX17	-9009

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COA6	-10815
FXN	-10753
TIMM44	-10695
ATP5MC1	-10679
TIMM22	-10616
CYC1	-10536
TOMM5	-10516
TOMM22	-10381
CHCHD4	-10295
ATP5F1B	-10186
TOMM6	-10163
TIMM8A	-9973
TIMM8B	-9925
GFER	-9639
TIMM23	-9624
TOMM40	-9328
TIMM17A	-9310
VDAC1	-9241
HSPA9	-9167
COX17	-9009
ATP5F1A	-8780
TIMM10	-8608
SLC25A6	-8441
HSCB	-8415
COA4	-8383
TIMM13	-8247
NDUFB8	-8124
SLC25A12	-7968
CHCHD2	-7908
TOMM20	-7871
CHCHD3	-7572
CS	-7474
BCS1L	-7442
TIMM50	-7384
PITRM1	-7266
HSPD1	-7042
MTX2	-7036
PAM16	-6680
PMPCA	-6095
GRPEL2	-6018
CHCHD10	-5867
TIMM9	-5815
DNAJC19	-5805
COX19	-5531
SLC25A4	-5222
CHCHD5	-5103
TOMM70	-5097
TIMM21	-5088
SAMM50	-4915
GRPEL1	-4827
TOMM7	-4720
TIMM17B	-4692
ACO2	-4669
TIMM10B	-4629
CMC2	-4506
CMC4	-3761
PMPCB	-3587
IDH3G	-3364
SLC25A13	-2010
CHCHD7	-908
MTX1	-219
DLD	4942
COQ2	6802

---

Nucleotide biosynthesis

set	Nucleotide biosynthesis
setSize	12
pANOVA	0.000158
s.dist	-0.63
p.adjustANOVA	0.00149

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PAICS	-10738
ATIC	-10499
ADSL	-9903
PFAS	-9865
CAD	-8737
GART	-8706
GMPS	-7046
IMPDH2	-6249
DHODH	-6113
PPAT	-2473
IMPDH1	-1998
UMPS	977

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PAICS	-10738
ATIC	-10499
ADSL	-9903
PFAS	-9865
CAD	-8737
GART	-8706
GMPS	-7046
IMPDH2	-6249
DHODH	-6113
PPAT	-2473
IMPDH1	-1998
UMPS	977

---

L13a-mediated translational silencing of Ceruloplasmin expression

set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	110
pANOVA	1.15e-29
s.dist	-0.623
p.adjustANOVA	1.59e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
EIF4H	-8586
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
EIF3G	-8229
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
EIF4G1	-7513
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
EIF3H	-6411
RPL22	-6398
EIF4A1	-6254
RPL21	-6245
EIF3L	-6237
RPLP1	-6177
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
EIF4B	-5727
RPL36AL	-5694
RPS5	-5467
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
EIF3E	-3969
RPL27A	-3830
EIF2S3	-3687
RPL26	-3436
EIF3A	-2993
EIF3F	-2893
EIF2S1	-2885
RPL26L1	-2674
EIF2S2	-1965
EIF4E	-1527
EIF3J	-1222
PABPC1	-591
RPL3L	1485
EIF4A2	2695
RPS4Y1	2742
RPS26	6214
EIF1AX	6407

---

Release of apoptotic factors from the mitochondria

set	Release of apoptotic factors from the mitochondria
setSize	6
pANOVA	0.00848
s.dist	-0.621
p.adjustANOVA	0.0442

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BAK1	-10221
BAX	-8118
DIABLO	-7954
CYCS	-6499
GSDMD	-5060
GSDME	-2222

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BAK1	-10221
BAX	-8118
DIABLO	-7954
CYCS	-6499
GSDMD	-5060
GSDME	-2222

---

GTP hydrolysis and joining of the 60S ribosomal subunit

set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	111
pANOVA	1.25e-29
s.dist	-0.62
p.adjustANOVA	1.59e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
EIF4H	-8586
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
EIF3G	-8229
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
EIF4G1	-7513
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
EIF5	-6459
RPL28	-6445
RPS12	-6437
EIF3H	-6411
RPL22	-6398
EIF4A1	-6254
RPL21	-6245
EIF3L	-6237
RPLP1	-6177
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
EIF4B	-5727
RPL36AL	-5694
RPS5	-5467
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
EIF3E	-3969
RPL27A	-3830
EIF2S3	-3687
RPL26	-3436
EIF3A	-2993
EIF3F	-2893
EIF2S1	-2885
RPL26L1	-2674
EIF2S2	-1965
EIF4E	-1527
EIF3J	-1222
RPL3L	1485
EIF4A2	2695
RPS4Y1	2742
EIF5B	3096
RPS26	6214
EIF1AX	6407

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	100
pANOVA	7.88e-27
s.dist	-0.62
p.adjustANOVA	5.64e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
DDIT3	-9949
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
DDIT3	-9949
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
CEBPG	-7924
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
TRIB3	-7568
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
GCN1	-6329
RPL21	-6245
RPLP1	-6177
RPS27A	-5923
RPS15A	-5860
EIF2AK4	-5766
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
RPL27A	-3830
EIF2S3	-3687
ATF4	-3673
ATF3	-3663
RPL26	-3436
EIF2S1	-2885
RPL26L1	-2674
EIF2S2	-1965
IMPACT	-951
RPL3L	1485
RPS4Y1	2742
ASNS	5520
CEBPB	5599
RPS26	6214
ATF2	8191

---

Cohesin Loading onto Chromatin

set	Cohesin Loading onto Chromatin
setSize	10
pANOVA	0.000731
s.dist	0.617
p.adjustANOVA	0.00579

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NIPBL	10646
STAG2	10561
PDS5B	9808
SMC3	9649
RAD21	9282
MAU2	8423
PDS5A	4222
WAPL	4212
STAG1	2170
SMC1A	288

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NIPBL	10646
STAG2	10561
PDS5B	9808
SMC3	9649
RAD21	9282
MAU2	8423
PDS5A	4222
WAPL	4212
STAG1	2170
SMC1A	288

---

Cap-dependent Translation Initiation

set	Cap-dependent Translation Initiation
setSize	118
pANOVA	8.08e-31
s.dist	-0.614
p.adjustANOVA	1.42e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
EIF4H	-8586
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
EIF3G	-8229
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
EIF4EBP1	-7960
EIF2B3	-7914
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
EIF4G1	-7513
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
EIF2B2	-6501
EIF5	-6459
RPL28	-6445
RPS12	-6437
EIF3H	-6411
RPL22	-6398
EIF4A1	-6254
RPL21	-6245
EIF3L	-6237
EIF2B5	-6215
RPLP1	-6177
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
EIF4B	-5727
RPL36AL	-5694
RPS5	-5467
EIF2B4	-5272
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
EIF2B1	-4095
EIF3E	-3969
RPL27A	-3830
EIF2S3	-3687
RPL26	-3436
EIF3A	-2993
EIF3F	-2893
EIF2S1	-2885
RPL26L1	-2674
EIF2S2	-1965
EIF4E	-1527
EIF3J	-1222
PABPC1	-591
RPL3L	1485
EIF4A2	2695
RPS4Y1	2742
EIF5B	3096
RPS26	6214
EIF1AX	6407

---

Eukaryotic Translation Initiation

set	Eukaryotic Translation Initiation
setSize	118
pANOVA	8.08e-31
s.dist	-0.614
p.adjustANOVA	1.42e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35A	-10314
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
EIF3I	-9532
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
EIF4H	-8586
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
EIF3G	-8229
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
EIF4EBP1	-7960
EIF2B3	-7914
RPS27L	-7769
RPS28	-7746
RPL37	-7713
RPSA	-7582
EIF4G1	-7513
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
EIF2B2	-6501
EIF5	-6459
RPL28	-6445
RPS12	-6437
EIF3H	-6411
RPL22	-6398
EIF4A1	-6254
RPL21	-6245
EIF3L	-6237
EIF2B5	-6215
RPLP1	-6177
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
EIF4B	-5727
RPL36AL	-5694
RPS5	-5467
EIF2B4	-5272
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPLP2	-5083
RPL23A	-4710
RPL14	-4505
RPS3A	-4498
RPS2	-4449
EIF2B1	-4095
EIF3E	-3969
RPL27A	-3830
EIF2S3	-3687
RPL26	-3436
EIF3A	-2993
EIF3F	-2893
EIF2S1	-2885
RPL26L1	-2674
EIF2S2	-1965
EIF4E	-1527
EIF3J	-1222
PABPC1	-591
RPL3L	1485
EIF4A2	2695
RPS4Y1	2742
EIF5B	3096
RPS26	6214
EIF1AX	6407

---

Translation

set	Translation
setSize	293
pANOVA	1.36e-70
s.dist	-0.601
p.adjustANOVA	2.63e-67

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SRPRB	-10828
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MARS2	-10667
VARS2	-10632
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
TSFM	-10558
SEC61A1	-10547
MRPL37	-10545
AIMP2	-10529
FARSA	-10520
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
NARS2	-10325

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SRPRB	-10828
MT-RNR2	-10737
MRPL12	-10724
MRPL57	-10718
MRPL17	-10715
MRPL34	-10677
MARS2	-10667
VARS2	-10632
MRPS7	-10627
MRPL16	-10565
MT-RNR1	-10561
TSFM	-10558
SEC61A1	-10547
MRPL37	-10545
AIMP2	-10529
FARSA	-10520
MRPS21	-10500
GADD45GIP1	-10465
MRPS16	-10342
NARS2	-10325
RPL35A	-10314
EARS2	-10256
MRPL20	-10240
MRPL49	-10231
SSR4	-10215
MRPS15	-10213
SEC61G	-10208
MRPS28	-10199
MRPS25	-10192
EIF3B	-10153
VARS1	-10119
SEC61B	-10118
MRPL4	-10113
RPS7	-10107
DDOST	-10098
RPS4X	-10083
RPL35	-10064
MRPS18C	-10058
MRPL3	-10050
MRPL51	-10029
MRPL9	-9996
RPS25	-9974
MRPL54	-9947
RPL39	-9902
RPL10A	-9900
MRPL40	-9883
RPS15	-9843
MRPL18	-9837
MRPL21	-9781
SEC11C	-9765
MRPL14	-9729
RPL37A	-9724
RPS27	-9692
RPL12	-9678
MRPL43	-9664
EIF3I	-9532
SARS2	-9512
RPS29	-9493
MRPS18B	-9476
PPA1	-9461
MRPL15	-9421
MRPL48	-9379
RPL27	-9376
WARS2	-9372
RPS23	-9366
SEC11A	-9348
RPS19	-9249
HARS1	-9230
MRPL27	-9214
RPL32	-9210
RPL8	-9182
MRPS23	-9170
YARS2	-9143
RPL18A	-9140
MRPS33	-9139
TRMT112	-9102
RPS13	-9069
TUFM	-9030
MRPS26	-9013
MRPL11	-8996
MRPL2	-8922
RPN1	-8901
RPS9	-8898
RPN2	-8897
RPS20	-8867
MRPS30	-8824
RPL7	-8818
MRPS27	-8817
MRPL36	-8812
MRPL24	-8789
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
AARS1	-8632
DARS2	-8625
MRPL46	-8624
AURKAIP1	-8616
MRPS14	-8605
RPL11	-8598
EIF4H	-8586
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
SSR3	-8498
RPL24	-8450
KARS1	-8420
MRPS11	-8389
UBA52	-8361
RPL15	-8344
MRPS34	-8343
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
EEF2	-8291
RPL22L1	-8268
APEH	-8252
CHCHD1	-8235
EIF3G	-8229
AARS2	-8209
MRPS18A	-8206
MRPL41	-8198
RPL34	-8174
FARSB	-8172
MRPS24	-8160
MRPS17	-8141
MRPS35	-8096
RPL19	-8095
MRPL23	-8083
RPL5	-8051
RPS14	-8044
RPLP0	-8042
EEF1E1	-8040
MRPL38	-8015
MRPS10	-7994
FAU	-7970
EIF4EBP1	-7960
EIF2B3	-7914
EEF1A1P5	-7861
SRP68	-7844
RPS27L	-7769
RPS28	-7746
IARS1	-7737
RPL37	-7713
ERAL1	-7603
TARS2	-7595
RPSA	-7582
EIF4G1	-7513
MRPL32	-7456
RPL18	-7362
RPS6	-7352
RPS17	-7300
MRPL52	-7286
MRPS36	-7283
EEF1B2	-7268
RPS8	-7263
RPL6	-7218
EEF1A1	-7133
SSR2	-7083
RPL23	-7070
RPL7A	-7016
RPS16	-6912
MRPL13	-6858
YARS1	-6831
MRPS5	-6803
RPS21	-6724
EIF3K	-6700
DAP3	-6643
SPCS1	-6626
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
MRPL47	-6516
EIF2B2	-6501
EIF5	-6459
RPL28	-6445
RPS12	-6437
EIF3H	-6411
RPL22	-6398
MRPS22	-6346
EIF4A1	-6254
RPL21	-6245
EIF3L	-6237
EIF2B5	-6215
RPLP1	-6177
EIF3D	-6167
QARS1	-6124
MRPS9	-6109
SRP14	-6103
EIF3M	-6070
EEF1G	-6066
MRPL22	-6039
RPS27A	-5923
MRPL28	-5910
RARS2	-5865
RPS15A	-5860
EIF4B	-5727
MTFMT	-5700
RPL36AL	-5694
SPCS2	-5637
MRPS2	-5543
MRPL39	-5494
RPS5	-5467
MRPL33	-5424
MRPL30	-5402
MRRF	-5314
EIF2B4	-5272
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPLP2	-5083
MRPL53	-5046
OXA1L	-5023
EEF1D	-4889
SRP72	-4844
GARS1	-4779
RPL23A	-4710
FARS2	-4708
MRPL55	-4696
MRPL10	-4693
PARS2	-4625
SARS1	-4601
MRPL45	-4519
RPL14	-4505
RPS3A	-4498
EPRS1	-4453
RPS2	-4449
MRPL19	-4442
SRPRA	-4136
MARS1	-4123
EIF2B1	-4095
PPA2	-4018
EIF3E	-3969
MRPL44	-3863
RPL27A	-3830
HARS2	-3771
EIF2S3	-3687
LARS1	-3649
RPL26	-3436
MRPL58	-3372
TARS1	-3309
PTCD3	-3265
MTIF2	-3055
LARS2	-3026
EIF3A	-2993
NARS1	-2936
EIF3F	-2893
EIF2S1	-2885
IARS2	-2797
RPL26L1	-2674
CARS1	-2165
SEC61A2	-2080
SRP54	-1981
EIF2S2	-1965
N6AMT1	-1581
EIF4E	-1527
SRP19	-1452
MRPS6	-1409
EIF3J	-1222
SRP9	-838
GSPT2	-748
PABPC1	-591
RARS1	-516
AIMP1	-390
GSPT1	-168
TRAM1	-32
ETF1	253
SPCS3	940
RPL3L	1485
MRPL35	2184
MRPS31	2353
EIF4A2	2695
GFM1	2700
RPS4Y1	2742
EIF5B	3096
MRPL42	3107
MTIF3	3693
MRPL50	4502
DARS1	4906
SSR1	4910
RPS26	6214
EIF1AX	6407
GFM2	6932
EEF1A2	7215
MRPL1	8557
WARS1	8694
CARS2	8969
MTRF1L	10143

---

SARS-CoV-2 modulates host translation machinery

set	SARS-CoV-2 modulates host translation machinery
setSize	49
pANOVA	5.28e-13
s.dist	-0.596
p.adjustANOVA	1.93e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNRPG	-10469
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
SNRPE	-9833
RPS27	-9692
RPS29	-9493
RPS23	-9366
SNRPB	-9362
RPS19	-9249
SNRPD2	-9093
RPS13	-9069
RPS9	-8898
RPS20	-8867
GEMIN4	-8763
GEMIN6	-8650
RPS11	-8581
RPS3	-8338
GEMIN5	-8188

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNRPG	-10469
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
SNRPE	-9833
RPS27	-9692
RPS29	-9493
RPS23	-9366
SNRPB	-9362
RPS19	-9249
SNRPD2	-9093
RPS13	-9069
RPS9	-8898
RPS20	-8867
GEMIN4	-8763
GEMIN6	-8650
RPS11	-8581
RPS3	-8338
GEMIN5	-8188
RPS14	-8044
FAU	-7970
SNRPD1	-7854
RPS27L	-7769
RPS28	-7746
RPSA	-7582
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPS16	-6912
SNRPF	-6760
RPS21	-6724
RPS10	-6588
RPS12	-6437
RPS27A	-5923
RPS15A	-5860
DDX20	-5666
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPS3A	-4498
RPS2	-4449
GEMIN7	-2934
SMN1	-379
SNRPD3	-159
RPS4Y1	2742
GEMIN2	4066
RPS26	6214
GEMIN8	7687

---

rRNA processing in the nucleus and cytosol

set	rRNA processing in the nucleus and cytosol
setSize	189
pANOVA	6.04e-45
s.dist	-0.592
p.adjustANOVA	3.89e-42

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPP25	-10842
EBNA1BP2	-10669
EXOSC2	-10635
EXOSC6	-10625
EXOSC1	-10587
NHP2	-10549
NAT10	-10542
UTP18	-10440
RRP36	-10427
WDR46	-10365
BOP1	-10336
UTP4	-10318
PNO1	-10316
RPL35A	-10314
IMP3	-10308
PDCD11	-10296
RCL1	-10217
IMP4	-10116
RPS7	-10107
EXOSC5	-10092

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPP25	-10842
EBNA1BP2	-10669
EXOSC2	-10635
EXOSC6	-10625
EXOSC1	-10587
NHP2	-10549
NAT10	-10542
UTP18	-10440
RRP36	-10427
WDR46	-10365
BOP1	-10336
UTP4	-10318
PNO1	-10316
RPL35A	-10314
IMP3	-10308
PDCD11	-10296
RCL1	-10217
IMP4	-10116
RPS7	-10107
EXOSC5	-10092
RPS4X	-10083
RPL35	-10064
UTP11	-10023
UTP25	-10001
RPS25	-9974
RPL39	-9902
RPL10A	-9900
TSR1	-9893
NOL9	-9872
RPS15	-9843
NOP14	-9831
RPL37A	-9724
NOL6	-9702
RPS27	-9692
EMG1	-9688
RPL12	-9678
DHX37	-9626
TSR3	-9533
RPS29	-9493
RPL27	-9376
RPS23	-9366
EXOSC8	-9355
GNL3	-9339
UTP14A	-9279
RPS19	-9249
NIP7	-9248
EXOSC7	-9227
RPL32	-9210
RPP40	-9202
RPL8	-9182
RRP9	-9163
WDR12	-9147
RPL18A	-9140
TRMT112	-9102
RPS13	-9069
RPS9	-8898
DKC1	-8895
RPS20	-8867
RPL7	-8818
WDR18	-8756
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
PES1	-8296
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
NOC4L	-8265
RRP1	-8263
NOP10	-8242
NOB1	-8223
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
NOL12	-7862
RPS27L	-7769
EXOSC3	-7748
RPS28	-7746
RPL37	-7713
FTSJ3	-7707
NOP2	-7643
RPSA	-7582
LTV1	-7497
NOP56	-7383
RPL18	-7362
RPS6	-7352
RRP7A	-7346
RIOK1	-7324
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPP21	-7169
RPL23	-7070
RPL7A	-7016
ISG20L2	-6958
RPS16	-6912
RPS21	-6724
FBL	-6693
SNU13	-6621
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
BYSL	-6210
RPLP1	-6177
DDX49	-6001
RPS27A	-5923
RPS15A	-5860
DDX47	-5752
RPL36AL	-5694
RPS5	-5467
DIMT1	-5352
TBL3	-5309
RPS18	-5196
RPS24	-5184
RPLP2	-5083
DDX21	-5043
CSNK1E	-5011
EXOSC4	-4974
DCAF13	-4966
UTP6	-4775
RPL23A	-4710
WDR75	-4638
WDR3	-4606
UTP20	-4555
RPL14	-4505
RPS3A	-4498
RPS2	-4449
BMS1	-4219
WDR43	-4193
SENP3	-4000
RPL27A	-3830
RPP14	-3522
UTP3	-3466
RPL26	-3436
XRN2	-3409
EXOSC10	-3104
LAS1L	-2788
RPL26L1	-2674
C1D	-2646
NOP58	-2450
RBM28	-2400
PWP2	-2372
HEATR1	-2050
RPP38	-1540
MPHOSPH10	-1536
EXOSC9	-1534
NCL	-1124
PELP1	-1092
GAR1	-548
UTP14C	-518
UTP15	140
NOL11	391
TEX10	490
WDR36	1090
ERI1	1444
RPL3L	1485
RPP30	1604
RPS4Y1	2742
DIS3	3443
CSNK1D	3902
FCF1	4460
RIOK2	5348
THUMPD1	5418
KRR1	5609
RPS26	6214
RIOK3	6757
DDX52	7025
MPHOSPH6	10669

---

Mitochondrial tRNA aminoacylation

set	Mitochondrial tRNA aminoacylation
setSize	21
pANOVA	2.66e-06
s.dist	-0.592
p.adjustANOVA	3.99e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MARS2	-10667
VARS2	-10632
NARS2	-10325
EARS2	-10256
SARS2	-9512
WARS2	-9372
YARS2	-9143
DARS2	-8625
KARS1	-8420
AARS2	-8209
TARS2	-7595
QARS1	-6124
RARS2	-5865
GARS1	-4779
FARS2	-4708
PARS2	-4625
PPA2	-4018
HARS2	-3771
LARS2	-3026
IARS2	-2797

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MARS2	-10667
VARS2	-10632
NARS2	-10325
EARS2	-10256
SARS2	-9512
WARS2	-9372
YARS2	-9143
DARS2	-8625
KARS1	-8420
AARS2	-8209
TARS2	-7595
QARS1	-6124
RARS2	-5865
GARS1	-4779
FARS2	-4708
PARS2	-4625
PPA2	-4018
HARS2	-3771
LARS2	-3026
IARS2	-2797
CARS2	8969

---

Major pathway of rRNA processing in the nucleolus and cytosol

set	Major pathway of rRNA processing in the nucleolus and cytosol
setSize	179
pANOVA	1.69e-42
s.dist	-0.591
p.adjustANOVA	8.17e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPP25	-10842
EBNA1BP2	-10669
EXOSC2	-10635
EXOSC6	-10625
EXOSC1	-10587
UTP18	-10440
RRP36	-10427
WDR46	-10365
BOP1	-10336
UTP4	-10318
PNO1	-10316
RPL35A	-10314
IMP3	-10308
PDCD11	-10296
RCL1	-10217
IMP4	-10116
RPS7	-10107
EXOSC5	-10092
RPS4X	-10083
RPL35	-10064

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPP25	-10842
EBNA1BP2	-10669
EXOSC2	-10635
EXOSC6	-10625
EXOSC1	-10587
UTP18	-10440
RRP36	-10427
WDR46	-10365
BOP1	-10336
UTP4	-10318
PNO1	-10316
RPL35A	-10314
IMP3	-10308
PDCD11	-10296
RCL1	-10217
IMP4	-10116
RPS7	-10107
EXOSC5	-10092
RPS4X	-10083
RPL35	-10064
UTP11	-10023
UTP25	-10001
RPS25	-9974
RPL39	-9902
RPL10A	-9900
TSR1	-9893
NOL9	-9872
RPS15	-9843
NOP14	-9831
RPL37A	-9724
NOL6	-9702
RPS27	-9692
EMG1	-9688
RPL12	-9678
DHX37	-9626
RPS29	-9493
RPL27	-9376
RPS23	-9366
EXOSC8	-9355
GNL3	-9339
UTP14A	-9279
RPS19	-9249
NIP7	-9248
EXOSC7	-9227
RPL32	-9210
RPP40	-9202
RPL8	-9182
RRP9	-9163
WDR12	-9147
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
WDR18	-8756
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
PES1	-8296
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
NOC4L	-8265
RRP1	-8263
NOB1	-8223
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
NOL12	-7862
RPS27L	-7769
EXOSC3	-7748
RPS28	-7746
RPL37	-7713
FTSJ3	-7707
RPSA	-7582
LTV1	-7497
NOP56	-7383
RPL18	-7362
RPS6	-7352
RRP7A	-7346
RIOK1	-7324
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPP21	-7169
RPL23	-7070
RPL7A	-7016
ISG20L2	-6958
RPS16	-6912
RPS21	-6724
FBL	-6693
SNU13	-6621
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
BYSL	-6210
RPLP1	-6177
DDX49	-6001
RPS27A	-5923
RPS15A	-5860
DDX47	-5752
RPL36AL	-5694
RPS5	-5467
TBL3	-5309
RPS18	-5196
RPS24	-5184
RPLP2	-5083
DDX21	-5043
CSNK1E	-5011
EXOSC4	-4974
DCAF13	-4966
UTP6	-4775
RPL23A	-4710
WDR75	-4638
WDR3	-4606
UTP20	-4555
RPL14	-4505
RPS3A	-4498
RPS2	-4449
BMS1	-4219
WDR43	-4193
SENP3	-4000
RPL27A	-3830
RPP14	-3522
UTP3	-3466
RPL26	-3436
XRN2	-3409
EXOSC10	-3104
LAS1L	-2788
RPL26L1	-2674
C1D	-2646
NOP58	-2450
RBM28	-2400
PWP2	-2372
HEATR1	-2050
RPP38	-1540
MPHOSPH10	-1536
EXOSC9	-1534
NCL	-1124
PELP1	-1092
UTP14C	-518
UTP15	140
NOL11	391
TEX10	490
WDR36	1090
ERI1	1444
RPL3L	1485
RPP30	1604
RPS4Y1	2742
DIS3	3443
CSNK1D	3902
FCF1	4460
RIOK2	5348
KRR1	5609
RPS26	6214
RIOK3	6757
DDX52	7025
MPHOSPH6	10669

---

rRNA processing

set	rRNA processing
setSize	213
pANOVA	1.07e-49
s.dist	-0.588
p.adjustANOVA	1.03e-46

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPP25	-10842
MT-RNR2	-10737
EBNA1BP2	-10669
EXOSC2	-10635
EXOSC6	-10625
EXOSC1	-10587
MT-RNR1	-10561
NHP2	-10549
NAT10	-10542
UTP18	-10440
RRP36	-10427
WDR46	-10365
BOP1	-10336
UTP4	-10318
PNO1	-10316
RPL35A	-10314
IMP3	-10308
PDCD11	-10296
RCL1	-10217
ELAC2	-10139

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPP25	-10842
MT-RNR2	-10737
EBNA1BP2	-10669
EXOSC2	-10635
EXOSC6	-10625
EXOSC1	-10587
MT-RNR1	-10561
NHP2	-10549
NAT10	-10542
UTP18	-10440
RRP36	-10427
WDR46	-10365
BOP1	-10336
UTP4	-10318
PNO1	-10316
RPL35A	-10314
IMP3	-10308
PDCD11	-10296
RCL1	-10217
ELAC2	-10139
IMP4	-10116
RPS7	-10107
EXOSC5	-10092
MRM2	-10086
RPS4X	-10083
MT-ND3	-10068
RPL35	-10064
UTP11	-10023
UTP25	-10001
RPS25	-9974
RPL39	-9902
RPL10A	-9900
TSR1	-9893
NOL9	-9872
RPS15	-9843
NOP14	-9831
RPL37A	-9724
NOL6	-9702
RPS27	-9692
EMG1	-9688
RPL12	-9678
HSD17B10	-9671
DHX37	-9626
MT-ATP8	-9565
TSR3	-9533
RPS29	-9493
RPL27	-9376
RPS23	-9366
EXOSC8	-9355
GNL3	-9339
UTP14A	-9279
RPS19	-9249
NIP7	-9248
EXOSC7	-9227
RPL32	-9210
RPP40	-9202
MRM3	-9187
RPL8	-9182
RRP9	-9163
WDR12	-9147
RPL18A	-9140
TRMT112	-9102
RPS13	-9069
RPS9	-8898
DKC1	-8895
RPS20	-8867
RPL7	-8818
WDR18	-8756
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
MT-ND4L	-8652
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
PES1	-8296
RPL4	-8294
RPL36A	-8292
MRM1	-8282
RPL22L1	-8268
NOC4L	-8265
RRP1	-8263
NOP10	-8242
NOB1	-8223
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
FAU	-7970
NOL12	-7862
RPS27L	-7769
EXOSC3	-7748
RPS28	-7746
RPL37	-7713
FTSJ3	-7707
NOP2	-7643
RPSA	-7582
LTV1	-7497
NOP56	-7383
RPL18	-7362
RPS6	-7352
RRP7A	-7346
RIOK1	-7324
RPS17	-7300
MT-ND2	-7271
RPS8	-7263
RPL6	-7218
MT-ND1	-7183
RPP21	-7169
RPL23	-7070
RPL7A	-7016
ISG20L2	-6958
MT-CO2	-6916
RPS16	-6912
RPS21	-6724
FBL	-6693
SNU13	-6621
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
BYSL	-6210
RPLP1	-6177
MT-ATP6	-6047
DDX49	-6001
RPS27A	-5923
RPS15A	-5860
DDX47	-5752
RPL36AL	-5694
RPS5	-5467
DIMT1	-5352
TBL3	-5309
MT-ND4	-5282
RPS18	-5196
RPS24	-5184
RPLP2	-5083
DDX21	-5043
CSNK1E	-5011
EXOSC4	-4974
DCAF13	-4966
MT-CO3	-4964
UTP6	-4775
RPL23A	-4710
WDR75	-4638
WDR3	-4606
UTP20	-4555
RPL14	-4505
RPS3A	-4498
RPS2	-4449
BMS1	-4219
WDR43	-4193
SENP3	-4000
PRORP	-3920
RPL27A	-3830
RPP14	-3522
UTP3	-3466
RPL26	-3436
XRN2	-3409
EXOSC10	-3104
TFB1M	-2974
LAS1L	-2788
MTERF4	-2701
RPL26L1	-2674
C1D	-2646
NOP58	-2450
RBM28	-2400
PWP2	-2372
HEATR1	-2050
MT-CYB	-1782
MT-ND5	-1733
RPP38	-1540
MPHOSPH10	-1536
EXOSC9	-1534
NCL	-1124
PELP1	-1092
TRMT10C	-799
GAR1	-548
UTP14C	-518
MT-CO1	49
UTP15	140
NOL11	391
TEX10	490
WDR36	1090
ERI1	1444
RPL3L	1485
RPP30	1604
RPS4Y1	2742
DIS3	3443
CSNK1D	3902
FCF1	4460
RIOK2	5348
THUMPD1	5418
KRR1	5609
RPS26	6214
RIOK3	6757
DDX52	7025
NSUN4	8464
MPHOSPH6	10669

---

Formation of xylulose-5-phosphate

set	Formation of xylulose-5-phosphate
setSize	5
pANOVA	0.0254
s.dist	-0.577
p.adjustANOVA	0.102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
XYLB	-9998
DCXR	-8257
CRYL1	-7709
AKR1A1	-7668
SORD	2625

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
XYLB	-9998
DCXR	-8257
CRYL1	-7709
AKR1A1	-7668
SORD	2625

---

Classical antibody-mediated complement activation

set	Classical antibody-mediated complement activation
setSize	69
pANOVA	1.19e-16
s.dist	-0.576
p.adjustANOVA	5.47e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
C1QB	-10817
C1QC	-10809
IGKV2-28	-10807
IGKV1-33	-10805
IGLV6-57	-10802
IGKV4-1	-10770
IGLV1-36	-10734
IGLV3-27	-10723
IGLC2	-10702
C1QA	-10645
IGHV4-34	-10617
IGLV7-43	-10594
IGKV3-20	-10513
IGLV2-11	-10488
IGKV3D-20	-10456
IGLV1-51	-10379
IGLV3-1	-10206
IGLV7-46	-10095
IGLC3	-10035
IGLV1-47	-9946

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
C1QB	-10817
C1QC	-10809
IGKV2-28	-10807
IGKV1-33	-10805
IGLV6-57	-10802
IGKV4-1	-10770
IGLV1-36	-10734
IGLV3-27	-10723
IGLC2	-10702
C1QA	-10645
IGHV4-34	-10617
IGLV7-43	-10594
IGKV3-20	-10513
IGLV2-11	-10488
IGKV3D-20	-10456
IGLV1-51	-10379
IGLV3-1	-10206
IGLV7-46	-10095
IGLC3	-10035
IGLV1-47	-9946
IGLV3-21	-9929
IGLV3-19	-9884
IGLV1-44	-9858
IGKV1D-39	-9779
IGLV3-25	-9665
IGHV1-2	-9628
IGHV2-70	-9589
IGHG4	-9495
IGHV3-33	-9479
IGLV2-8	-9219
IGLC1	-9026
IGLV2-18	-8832
IGKV1-16	-8690
IGHV3-7	-8400
IGKV3-15	-8367
IGLC7	-8214
IGLV2-23	-8115
IGKC	-8001
IGLV1-40	-7292
IGHV1-46	-7248
IGHV3-48	-6908
IGHV4-39	-6727
IGHV2-5	-6647
IGKV1-5	-6206
IGHG3	-6202
IGHV4-59	-5710
IGKV1-12	-5595
IGHV3-11	-5440
IGHG1	-5252
IGHG2	-4240
C1S	-3483
IGHV3-30	-3434
IGLV5-45	-3183
IGHV3-13	-2907
IGKV1-17	-2753
IGLV2-14	-2027
IGLV8-61	-1836
IGKV2D-28	-1493
IGKV2-29	-755
IGHV3-23	90
IGHV1-69	125
IGKV2-30	689
IGLV4-69	1961
IGLV10-54	2526
C1R	4842
IGKV3-11	7469
IGHV3-53	8185
IGLV4-60	8394
IGLV3-12	10166

---

Formation of the ternary complex, and subsequently, the 43S complex

set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	1.11e-12
s.dist	-0.576
p.adjustANOVA	3.89e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
RPS27	-9692
EIF3I	-9532
RPS29	-9493
RPS23	-9366
RPS19	-9249
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPS11	-8581
RPS3	-8338
EIF3G	-8229
RPS14	-8044
FAU	-7970
RPS27L	-7769
RPS28	-7746

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
RPS27	-9692
EIF3I	-9532
RPS29	-9493
RPS23	-9366
RPS19	-9249
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPS11	-8581
RPS3	-8338
EIF3G	-8229
RPS14	-8044
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPSA	-7582
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPS10	-6588
RPS12	-6437
EIF3H	-6411
EIF3L	-6237
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
RPS5	-5467
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPS3A	-4498
RPS2	-4449
EIF3E	-3969
EIF2S3	-3687
EIF3A	-2993
EIF3F	-2893
EIF2S1	-2885
EIF2S2	-1965
EIF3J	-1222
RPS4Y1	2742
RPS26	6214
EIF1AX	6407

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.00103
s.dist	-0.571
p.adjustANOVA	0.00787

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNRPG	-10469
SNRPE	-9833
SLBP	-9459
SNRPB	-9362
NCBP2	-7851
LSM11	-7765
SNRPF	-6760
LSM10	-4071
ZNF473	-3833
SNRPD3	-159
NCBP1	2072

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNRPG	-10469
SNRPE	-9833
SLBP	-9459
SNRPB	-9362
NCBP2	-7851
LSM11	-7765
SNRPF	-6760
LSM10	-4071
ZNF473	-3833
SNRPD3	-159
NCBP1	2072

---

Folding of actin by CCT/TriC

set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.00203
s.dist	-0.564
p.adjustANOVA	0.0137

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCT4	-10388
CCT7	-9695
CCT3	-9539
CCT6A	-8656
CCT8	-8599
CCT5	-8029
CCT2	-5546
TCP1	-4794
CCT6B	-580
ACTB	5309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCT4	-10388
CCT7	-9695
CCT3	-9539
CCT6A	-8656
CCT8	-8599
CCT5	-8029
CCT2	-5546
TCP1	-4794
CCT6B	-580
ACTB	5309

---

Ribosomal scanning and start codon recognition

set	Ribosomal scanning and start codon recognition
setSize	58
pANOVA	1.5e-13
s.dist	-0.56
p.adjustANOVA	5.92e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
RPS27	-9692
EIF3I	-9532
RPS29	-9493
RPS23	-9366
RPS19	-9249
RPS13	-9069
RPS9	-8898
RPS20	-8867
EIF4H	-8586
RPS11	-8581
RPS3	-8338
EIF3G	-8229
RPS14	-8044
FAU	-7970
RPS27L	-7769

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3B	-10153
RPS7	-10107
RPS4X	-10083
RPS25	-9974
RPS15	-9843
RPS27	-9692
EIF3I	-9532
RPS29	-9493
RPS23	-9366
RPS19	-9249
RPS13	-9069
RPS9	-8898
RPS20	-8867
EIF4H	-8586
RPS11	-8581
RPS3	-8338
EIF3G	-8229
RPS14	-8044
FAU	-7970
RPS27L	-7769
RPS28	-7746
RPSA	-7582
EIF4G1	-7513
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPS16	-6912
RPS21	-6724
EIF3K	-6700
RPS10	-6588
EIF5	-6459
RPS12	-6437
EIF3H	-6411
EIF4A1	-6254
EIF3L	-6237
EIF3D	-6167
EIF3M	-6070
RPS27A	-5923
RPS15A	-5860
EIF4B	-5727
RPS5	-5467
EIF3C	-5239
RPS18	-5196
RPS24	-5184
RPS3A	-4498
RPS2	-4449
EIF3E	-3969
EIF2S3	-3687
EIF3A	-2993
EIF3F	-2893
EIF2S1	-2885
EIF2S2	-1965
EIF4E	-1527
EIF3J	-1222
EIF4A2	2695
RPS4Y1	2742
RPS26	6214
EIF1AX	6407

---

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

set	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
setSize	5
pANOVA	0.0301
s.dist	-0.56
p.adjustANOVA	0.116

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GAS6	-10599
PROZ	-6508
PROS1	-6348
PROC	-4989
BGLAP	-1634

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GAS6	-10599
PROZ	-6508
PROS1	-6348
PROC	-4989
BGLAP	-1634

---

Cytosolic iron-sulfur cluster assembly

set	Cytosolic iron-sulfur cluster assembly
setSize	13
pANOVA	0.000472
s.dist	-0.56
p.adjustANOVA	0.00399

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CIAPIN1	-10384
CIAO1	-10052
NUBP2	-8835
NUBP1	-7969
RTEL1	-7410
ERCC2	-7317
POLD1	-7050
CIAO2B	-6120
CIAO3	-5947
NDOR1	-5661
ABCB7	-4559
MMS19	-3707
BRIP1	6880

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CIAPIN1	-10384
CIAO1	-10052
NUBP2	-8835
NUBP1	-7969
RTEL1	-7410
ERCC2	-7317
POLD1	-7050
CIAO2B	-6120
CIAO3	-5947
NDOR1	-5661
ABCB7	-4559
MMS19	-3707
BRIP1	6880

---

Selenoamino acid metabolism

set	Selenoamino acid metabolism
setSize	115
pANOVA	3.38e-25
s.dist	-0.559
p.adjustANOVA	2.25e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AIMP2	-10529
RPL35A	-10314
EEFSEC	-10115
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
AHCY	-9963
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AIMP2	-10529
RPL35A	-10314
EEFSEC	-10115
RPS7	-10107
RPS4X	-10083
RPL35	-10064
RPS25	-9974
AHCY	-9963
RPL39	-9902
RPL10A	-9900
RPS15	-9843
RPL37A	-9724
RPS27	-9692
RPL12	-9678
RPS29	-9493
RPL27	-9376
RPS23	-9366
RPS19	-9249
RPL32	-9210
RPL8	-9182
RPL18A	-9140
RPS13	-9069
RPS9	-8898
RPS20	-8867
RPL7	-8818
RPL36	-8752
RPL38	-8730
RPL29	-8721
RPL30	-8707
RPL31	-8696
RPL11	-8598
RPL41	-8584
RPS11	-8581
RPL39L	-8567
RPL10	-8533
RPL13A	-8502
RPL24	-8450
KARS1	-8420
UBA52	-8361
RPL15	-8344
RPS3	-8338
RPL9	-8330
RPL4	-8294
RPL36A	-8292
RPL22L1	-8268
RPL34	-8174
RPL19	-8095
RPL5	-8051
RPS14	-8044
RPLP0	-8042
EEF1E1	-8040
FAU	-7970
RPS27L	-7769
RPS28	-7746
IARS1	-7737
RPL37	-7713
RPSA	-7582
PAPSS1	-7563
RPL18	-7362
RPS6	-7352
RPS17	-7300
RPS8	-7263
RPL6	-7218
RPL23	-7070
RPL7A	-7016
RPS16	-6912
RPS21	-6724
RPL3	-6594
RPS10	-6588
RPL17	-6568
RPL13	-6547
RPL28	-6445
RPS12	-6437
RPL22	-6398
RPL21	-6245
RPLP1	-6177
QARS1	-6124
TXNRD1	-6032
RPS27A	-5923
RPS15A	-5860
RPL36AL	-5694
RPS5	-5467
RPS18	-5196
RPS24	-5184
RPLP2	-5083
GSR	-4796
RPL23A	-4710
SARS1	-4601
RPL14	-4505
RPS3A	-4498
EPRS1	-4453
RPS2	-4449
MARS1	-4123
RPL27A	-3830
LARS1	-3649
SEPHS2	-3520
RPL26	-3436
RPL26L1	-2674
CBS	-798
SCLY	-754
RARS1	-516
AIMP1	-390
SEPSECS	1390
RPL3L	1485
PSTK	1551
INMT	1929
NNMT	2471
RPS4Y1	2742
SECISBP2	3596
DARS1	4906
GNMT	5059
RPS26	6214
PAPSS2	6217
HNMT	8428
CTH	8735

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report