date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -2.4785772
A1BG -1.7542511
A1BG-AS1 -1.0734377
A1CF 0.5521424
A2M 1.6603819
A2M-AS1 1.3818491

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Formation of ATP by chemiosmotic coupling 20 3.91e-11 -0.853 6.75e-10
Peptide chain elongation 88 1.15e-42 -0.843 1.31e-40
Formation of a pool of free 40S subunits 100 3.11e-48 -0.842 4.29e-46
Eukaryotic Translation Elongation 93 3.70e-44 -0.834 4.47e-42
Viral mRNA Translation 88 1.49e-41 -0.831 1.60e-39
L13a-mediated translational silencing of Ceruloplasmin expression 110 6.06e-51 -0.826 1.17e-48
Modulation by Mtb of host immune system 7 1.53e-04 -0.826 8.77e-04
GTP hydrolysis and joining of the 60S ribosomal subunit 111 7.36e-51 -0.822 1.29e-48
SARS-CoV-1 modulates host translation machinery 36 1.72e-17 -0.819 5.93e-16
Cap-dependent Translation Initiation 118 2.87e-53 -0.817 6.17e-51
Eukaryotic Translation Initiation 118 2.87e-53 -0.817 6.17e-51
Formation of the ternary complex, and subsequently, the 43S complex 51 9.14e-24 -0.813 3.92e-22
Eukaryotic Translation Termination 92 2.94e-41 -0.810 2.84e-39
Mitochondrial translation initiation 90 4.02e-40 -0.807 3.24e-38
SRP-dependent cotranslational protein targeting to membrane 111 6.91e-49 -0.805 1.03e-46
Selenocysteine synthesis 92 9.69e-41 -0.805 8.14e-39
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.37e-41 -0.802 2.41e-39
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.26e-26 -0.796 1.54e-24
Mitochondrial translation elongation 90 7.27e-39 -0.794 4.84e-37
Translation initiation complex formation 58 1.32e-25 -0.793 6.06e-24
Ribosomal scanning and start codon recognition 58 1.66e-25 -0.791 7.46e-24
Mitochondrial translation termination 90 6.58e-38 -0.783 4.24e-36
Mitochondrial translation 96 1.31e-39 -0.776 9.37e-38
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.86e-40 -0.764 4.39e-38
Complex III assembly 23 2.46e-10 -0.762 3.71e-09
Phosphate bond hydrolysis by NUDT proteins 7 5.94e-04 -0.749 2.97e-03
SUMO is conjugated to E1 (UBA2:SAE1) 5 3.98e-03 -0.744 1.57e-02
Arachidonate production from DAG 5 4.10e-03 -0.741 1.60e-02
Translation 293 0.00e+00 -0.732 1.00e-100
SARS-CoV-2 modulates host translation machinery 49 8.66e-19 -0.730 3.16e-17
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.07e-08 -0.727 4.34e-07
Selenoamino acid metabolism 115 5.91e-40 -0.713 4.39e-38
Post-transcriptional silencing by small RNAs 7 1.11e-03 0.712 5.26e-03
Cristae formation 33 2.45e-12 -0.704 5.14e-11
Mitochondrial calcium ion transport 22 1.31e-08 -0.700 1.49e-07
Packaging Of Telomere Ends 18 2.90e-07 -0.698 2.68e-06
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 1.43e-03 -0.696 6.44e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 3.99e-37 -0.689 2.41e-35
Nonsense-Mediated Decay (NMD) 114 3.99e-37 -0.689 2.41e-35
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 8.05e-03 -0.684 2.87e-02
Mitochondrial RNA degradation 25 3.17e-09 -0.684 4.06e-08
rRNA processing in the mitochondrion 24 7.81e-09 -0.680 9.37e-08
Processing of SMDT1 15 5.06e-06 -0.680 3.92e-05
RNA Polymerase I Promoter Opening 17 1.39e-06 -0.676 1.16e-05
Major pathway of rRNA processing in the nucleolus and cytosol 179 6.86e-55 -0.674 1.89e-52
rRNA processing 213 5.13e-64 -0.669 2.48e-61
Regulation of expression of SLITs and ROBOs 149 3.07e-45 -0.668 3.96e-43
Complex I biogenesis 66 5.80e-21 -0.668 2.33e-19
rRNA processing in the nucleus and cytosol 189 1.50e-56 -0.666 5.79e-54
Cleavage of the damaged purine 22 7.86e-08 -0.661 7.82e-07


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Formation of ATP by chemiosmotic coupling 20 3.91e-11 -8.53e-01 6.75e-10
Peptide chain elongation 88 1.15e-42 -8.43e-01 1.31e-40
Formation of a pool of free 40S subunits 100 3.11e-48 -8.42e-01 4.29e-46
Eukaryotic Translation Elongation 93 3.70e-44 -8.34e-01 4.47e-42
Viral mRNA Translation 88 1.49e-41 -8.31e-01 1.60e-39
L13a-mediated translational silencing of Ceruloplasmin expression 110 6.06e-51 -8.26e-01 1.17e-48
Modulation by Mtb of host immune system 7 1.53e-04 -8.26e-01 8.77e-04
GTP hydrolysis and joining of the 60S ribosomal subunit 111 7.36e-51 -8.22e-01 1.29e-48
SARS-CoV-1 modulates host translation machinery 36 1.72e-17 -8.19e-01 5.93e-16
Cap-dependent Translation Initiation 118 2.87e-53 -8.17e-01 6.17e-51
Eukaryotic Translation Initiation 118 2.87e-53 -8.17e-01 6.17e-51
Formation of the ternary complex, and subsequently, the 43S complex 51 9.14e-24 -8.13e-01 3.92e-22
Eukaryotic Translation Termination 92 2.94e-41 -8.10e-01 2.84e-39
Mitochondrial translation initiation 90 4.02e-40 -8.07e-01 3.24e-38
SRP-dependent cotranslational protein targeting to membrane 111 6.91e-49 -8.05e-01 1.03e-46
Selenocysteine synthesis 92 9.69e-41 -8.05e-01 8.14e-39
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.37e-41 -8.02e-01 2.41e-39
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.26e-26 -7.96e-01 1.54e-24
Mitochondrial translation elongation 90 7.27e-39 -7.94e-01 4.84e-37
Translation initiation complex formation 58 1.32e-25 -7.93e-01 6.06e-24
Ribosomal scanning and start codon recognition 58 1.66e-25 -7.91e-01 7.46e-24
Mitochondrial translation termination 90 6.58e-38 -7.83e-01 4.24e-36
Mitochondrial translation 96 1.31e-39 -7.76e-01 9.37e-38
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.86e-40 -7.64e-01 4.39e-38
Complex III assembly 23 2.46e-10 -7.62e-01 3.71e-09
Phosphate bond hydrolysis by NUDT proteins 7 5.94e-04 -7.49e-01 2.97e-03
SUMO is conjugated to E1 (UBA2:SAE1) 5 3.98e-03 -7.44e-01 1.57e-02
Arachidonate production from DAG 5 4.10e-03 -7.41e-01 1.60e-02
Translation 293 0.00e+00 -7.32e-01 1.00e-100
SARS-CoV-2 modulates host translation machinery 49 8.66e-19 -7.30e-01 3.16e-17
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.07e-08 -7.27e-01 4.34e-07
Selenoamino acid metabolism 115 5.91e-40 -7.13e-01 4.39e-38
Post-transcriptional silencing by small RNAs 7 1.11e-03 7.12e-01 5.26e-03
Cristae formation 33 2.45e-12 -7.04e-01 5.14e-11
Mitochondrial calcium ion transport 22 1.31e-08 -7.00e-01 1.49e-07
Packaging Of Telomere Ends 18 2.90e-07 -6.98e-01 2.68e-06
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 1.43e-03 -6.96e-01 6.44e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 3.99e-37 -6.89e-01 2.41e-35
Nonsense-Mediated Decay (NMD) 114 3.99e-37 -6.89e-01 2.41e-35
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 8.05e-03 -6.84e-01 2.87e-02
Mitochondrial RNA degradation 25 3.17e-09 -6.84e-01 4.06e-08
rRNA processing in the mitochondrion 24 7.81e-09 -6.80e-01 9.37e-08
Processing of SMDT1 15 5.06e-06 -6.80e-01 3.92e-05
RNA Polymerase I Promoter Opening 17 1.39e-06 -6.76e-01 1.16e-05
Major pathway of rRNA processing in the nucleolus and cytosol 179 6.86e-55 -6.74e-01 1.89e-52
rRNA processing 213 5.13e-64 -6.69e-01 2.48e-61
Regulation of expression of SLITs and ROBOs 149 3.07e-45 -6.68e-01 3.96e-43
Complex I biogenesis 66 5.80e-21 -6.68e-01 2.33e-19
rRNA processing in the nucleus and cytosol 189 1.50e-56 -6.66e-01 5.79e-54
Cleavage of the damaged purine 22 7.86e-08 -6.61e-01 7.82e-07
Depurination 22 7.86e-08 -6.61e-01 7.82e-07
Recognition and association of DNA glycosylase with site containing an affected purine 22 7.86e-08 -6.61e-01 7.82e-07
Recycling of eIF2:GDP 8 1.36e-03 -6.54e-01 6.20e-03
Mitochondrial protein import 63 8.35e-19 -6.45e-01 3.10e-17
Regulation of NFE2L2 gene expression 8 1.73e-03 6.40e-01 7.61e-03
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 6.73e-03 -6.39e-01 2.46e-02
Respiratory electron transport 149 4.24e-41 -6.36e-01 3.90e-39
tRNA processing in the mitochondrion 24 6.94e-08 -6.36e-01 7.13e-07
Regulation of CDH11 mRNA translation by microRNAs 8 2.03e-03 6.30e-01 8.77e-03
Regulation of NPAS4 mRNA translation 8 2.03e-03 6.30e-01 8.77e-03
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 1.47e-02 -6.30e-01 4.66e-02
Interleukin-21 signaling 9 1.11e-03 6.28e-01 5.26e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.29e-11 -6.26e-01 2.35e-10
p53-Independent DNA Damage Response 39 1.29e-11 -6.26e-01 2.35e-10
p53-Independent G1/S DNA damage checkpoint 39 1.29e-11 -6.26e-01 2.35e-10
PDH complex synthesizes acetyl-CoA from PYR 5 1.54e-02 -6.25e-01 4.86e-02
Maturation of TCA enzymes and regulation of TCA cycle 20 1.31e-06 -6.25e-01 1.10e-05
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 8.47e-03 -6.21e-01 2.97e-02
Cellular response to mitochondrial stress 9 1.27e-03 -6.20e-01 5.88e-03
Vif-mediated degradation of APOBEC3G 41 7.06e-12 -6.19e-01 1.38e-10
HDMs demethylate histones 22 5.84e-07 6.15e-01 5.14e-06
SIRT1 negatively regulates rRNA expression 22 5.86e-07 -6.15e-01 5.14e-06
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.11e-04 -6.15e-01 2.18e-03
Influenza Viral RNA Transcription and Replication 135 1.03e-34 -6.12e-01 5.38e-33
Vpu mediated degradation of CD4 39 3.98e-11 -6.11e-01 6.80e-10
Regulation of NPAS4 gene expression 11 4.76e-04 6.08e-01 2.49e-03
Sulfide oxidation to sulfate 5 1.88e-02 -6.07e-01 5.71e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 2.14e-10 -6.03e-01 3.28e-09
Formation of xylulose-5-phosphate 5 1.97e-02 -6.02e-01 5.91e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 2.45e-11 -6.02e-01 4.30e-10
Cellular response to starvation 148 1.06e-36 -6.02e-01 6.22e-35
Proteasome assembly 50 2.03e-13 -6.00e-01 5.03e-12
Folding of actin by CCT/TriC 10 1.03e-03 -5.99e-01 4.93e-03
Cation-coupled Chloride cotransporters 6 1.12e-02 5.98e-01 3.77e-02
Citric acid cycle (TCA cycle) 34 1.64e-09 -5.97e-01 2.21e-08
Mitochondrial iron-sulfur cluster biogenesis 13 2.02e-04 -5.95e-01 1.15e-03
tRNA modification in the mitochondrion 9 2.06e-03 -5.93e-01 8.87e-03
Inhibition of DNA recombination at telomere 33 4.38e-09 -5.90e-01 5.46e-08
MET activates PI3K/AKT signaling 5 2.28e-02 5.88e-01 6.65e-02
Ubiquitin-dependent degradation of Cyclin D 39 2.25e-10 -5.87e-01 3.43e-09
p130Cas linkage to MAPK signaling for integrins 11 7.95e-04 -5.84e-01 3.87e-03
Negative regulation of NOTCH4 signaling 44 2.10e-11 -5.83e-01 3.72e-10
SLBP independent Processing of Histone Pre-mRNAs 10 1.41e-03 -5.83e-01 6.37e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 6.70e-06 -5.82e-01 5.16e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 7.09e-11 -5.81e-01 1.16e-09
TGFBR3 expression 20 6.96e-06 5.80e-01 5.29e-05
Mitochondrial protein degradation 96 8.19e-23 -5.80e-01 3.44e-21
Regulation of Apoptosis 40 2.62e-10 -5.77e-01 3.92e-09
Defective CFTR causes cystic fibrosis 47 7.95e-12 -5.76e-01 1.52e-10
Regulation of ornithine decarboxylase (ODC) 38 7.74e-10 -5.76e-01 1.09e-08
DNA methylation 18 2.46e-05 -5.74e-01 1.63e-04
Hh mutants are degraded by ERAD 42 1.23e-10 -5.74e-01 1.95e-09
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 2.67e-02 -5.72e-01 7.56e-02
Release of apoptotic factors from the mitochondria 6 1.61e-02 -5.67e-01 5.03e-02
Base-Excision Repair, AP Site Formation 29 1.24e-07 -5.67e-01 1.21e-06
RNA Polymerase III Chain Elongation 18 3.13e-05 -5.67e-01 2.06e-04
SCF(Skp2)-mediated degradation of p27/p21 50 4.18e-12 -5.66e-01 8.49e-11
Maturation of spike protein 9683686 5 2.88e-02 -5.64e-01 8.07e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 4.16e-14 -5.64e-01 1.24e-12
APC/C:Cdc20 mediated degradation of Securin 55 5.03e-13 -5.63e-01 1.18e-11
Influenza Infection 154 1.72e-33 -5.62e-01 8.50e-32
Autodegradation of the E3 ubiquitin ligase COP1 38 2.05e-09 -5.62e-01 2.73e-08
Cleavage of the damaged pyrimidine 27 4.37e-07 -5.62e-01 3.92e-06
Depyrimidination 27 4.37e-07 -5.62e-01 3.92e-06
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 4.37e-07 -5.62e-01 3.92e-06
SCF-beta-TrCP mediated degradation of Emi1 42 3.13e-10 -5.61e-01 4.61e-09
Metabolism of polyamines 46 4.98e-11 -5.60e-01 8.44e-10
PINK1-PRKN Mediated Mitophagy 31 6.98e-08 -5.59e-01 7.14e-07
rRNA modification in the nucleus and cytosol 59 1.05e-13 -5.59e-01 2.85e-12
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 4.12e-10 -5.57e-01 5.94e-09
Signaling by RNF43 mutants 7 1.08e-02 5.56e-01 3.67e-02
Hh mutants abrogate ligand secretion 43 3.26e-10 -5.54e-01 4.77e-09
RNA Polymerase I Promoter Escape 45 1.33e-10 -5.53e-01 2.09e-09
Aerobic respiration and respiratory electron transport 245 1.79e-50 -5.53e-01 2.89e-48
Abacavir ADME 5 3.25e-02 5.52e-01 8.86e-02
G2/M DNA replication checkpoint 5 3.28e-02 -5.51e-01 8.91e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 63 4.17e-14 -5.50e-01 1.24e-12
Complex IV assembly 45 1.97e-10 -5.48e-01 3.05e-09
Hedgehog ligand biogenesis 47 8.09e-11 -5.48e-01 1.30e-09
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 1.74e-13 -5.45e-01 4.37e-12
Defective pyroptosis 27 9.86e-07 -5.44e-01 8.46e-06
Defective binding of VWF variant to GPIb:IX:V 7 1.27e-02 -5.44e-01 4.18e-02
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.27e-02 -5.44e-01 4.18e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 5.86e-14 -5.43e-01 1.67e-12
Classical antibody-mediated complement activation 69 7.36e-15 -5.41e-01 2.29e-13
PI3K events in ERBB4 signaling 6 2.24e-02 5.38e-01 6.56e-02
Autodegradation of Cdh1 by Cdh1:APC/C 54 7.88e-12 -5.38e-01 1.52e-10
Zygotic genome activation (ZGA) 5 3.73e-02 5.38e-01 9.86e-02
CD22 mediated BCR regulation 58 1.78e-12 -5.35e-01 3.77e-11
Assembly of the ORC complex at the origin of replication 23 9.29e-06 -5.34e-01 6.87e-05
NADE modulates death signalling 5 3.88e-02 -5.34e-01 1.02e-01
Synthesis of Dolichyl-phosphate 6 2.39e-02 -5.33e-01 6.94e-02
Signaling by ROBO receptors 189 1.92e-36 -5.31e-01 1.09e-34
Cross-presentation of soluble exogenous antigens (endosomes) 35 5.50e-08 -5.31e-01 5.68e-07
CDK-mediated phosphorylation and removal of Cdc6 60 1.44e-12 -5.28e-01 3.13e-11
Synthesis of diphthamide-EEF2 8 9.69e-03 -5.28e-01 3.35e-02
Malate-aspartate shuttle 8 9.95e-03 -5.26e-01 3.43e-02
Calcitonin-like ligand receptors 5 4.18e-02 5.26e-01 1.08e-01
Protein methylation 15 4.65e-04 -5.22e-01 2.43e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 59 4.99e-12 -5.20e-01 1.00e-10
Regulation of Expression and Function of Type II Classical Cadherins 25 6.93e-06 5.19e-01 5.29e-05
Regulation of Homotypic Cell-Cell Adhesion 25 6.93e-06 5.19e-01 5.29e-05
Stabilization of p53 43 3.81e-09 -5.19e-01 4.77e-08
Orc1 removal from chromatin 58 8.28e-12 -5.18e-01 1.57e-10
Replacement of protamines by nucleosomes in the male pronucleus 13 1.21e-03 -5.18e-01 5.66e-03
Regulation of CDH11 Expression and Function 23 1.89e-05 5.15e-01 1.29e-04
Regulation of APC/C activators between G1/S and early anaphase 68 2.10e-13 -5.15e-01 5.13e-12
Creation of C4 and C2 activators 71 6.87e-14 -5.14e-01 1.92e-12
Alpha-oxidation of phytanate 6 2.94e-02 -5.13e-01 8.16e-02
RNA Polymerase III Transcription Termination 23 2.09e-05 -5.12e-01 1.41e-04
NRIF signals cell death from the nucleus 15 5.90e-04 -5.12e-01 2.95e-03
Apoptosis induced DNA fragmentation 10 5.02e-03 -5.12e-01 1.91e-02
Adenylate cyclase activating pathway 8 1.24e-02 5.10e-01 4.11e-02
Scavenging of heme from plasma 70 1.49e-13 -5.10e-01 3.79e-12
Deposition of new CENPA-containing nucleosomes at the centromere 38 5.28e-08 -5.10e-01 5.48e-07
Nucleosome assembly 38 5.28e-08 -5.10e-01 5.48e-07
G2 Phase 5 4.85e-02 -5.10e-01 1.20e-01
Degradation of GLI2 by the proteasome 45 3.33e-09 -5.09e-01 4.24e-08
Purine ribonucleoside monophosphate biosynthesis 9 8.20e-03 -5.09e-01 2.91e-02
Miscellaneous substrates 7 2.03e-02 5.07e-01 6.00e-02
Degradation of DVL 43 9.08e-09 -5.06e-01 1.06e-07
RORA activates gene expression 18 2.06e-04 5.05e-01 1.17e-03
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.83e-05 -5.05e-01 1.27e-04
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.61e-03 -5.05e-01 7.24e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 9.01e-12 -5.05e-01 1.69e-10
Assembly of the pre-replicative complex 87 3.97e-16 -5.04e-01 1.30e-14
G1/S DNA Damage Checkpoints 54 1.90e-10 -5.01e-01 2.96e-09
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.26e-05 -5.00e-01 2.13e-04
Removal of the Flap Intermediate 14 1.19e-03 -5.00e-01 5.58e-03
Regulation of RUNX3 expression and activity 45 6.74e-09 -4.99e-01 8.19e-08
Mitophagy 38 1.16e-07 -4.97e-01 1.14e-06
Formation of the ureteric bud 5 5.69e-02 -4.92e-01 1.35e-01
GLI3 is processed to GLI3R by the proteasome 46 7.92e-09 -4.92e-01 9.45e-08
p53-Dependent G1 DNA Damage Response 52 9.17e-10 -4.91e-01 1.27e-08
p53-Dependent G1/S DNA damage checkpoint 52 9.17e-10 -4.91e-01 1.27e-08
Degradation of AXIN 42 3.84e-08 -4.90e-01 4.12e-07
Displacement of DNA glycosylase by APEX1 9 1.10e-02 -4.90e-01 3.71e-02
Regulation of CDH11 function 10 7.43e-03 4.89e-01 2.68e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.12e-09 -4.88e-01 1.55e-08
DNA Replication Pre-Initiation 103 1.09e-17 -4.88e-01 3.82e-16
Protein hydroxylation 17 4.97e-04 -4.88e-01 2.57e-03
Androgen biosynthesis 5 5.94e-02 -4.87e-01 1.39e-01
Pentose phosphate pathway 13 2.39e-03 -4.86e-01 1.01e-02
CDH11 homotypic and heterotypic interactions 6 3.94e-02 4.86e-01 1.03e-01
rRNA modification in the mitochondrion 8 1.74e-02 -4.86e-01 5.35e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.70e-03 -4.84e-01 7.53e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 9.29e-06 -4.84e-01 6.87e-05
Ketone body metabolism 8 1.79e-02 -4.83e-01 5.48e-02
Cytosolic tRNA aminoacylation 24 4.27e-05 -4.82e-01 2.74e-04
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 8.92e-05 -4.82e-01 5.27e-04
Initial triggering of complement 79 1.25e-13 -4.82e-01 3.36e-12
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.86e-03 -4.82e-01 1.52e-02
Methionine salvage pathway 6 4.13e-02 -4.81e-01 1.07e-01
Synthesis of Ketone Bodies 6 4.13e-02 -4.81e-01 1.07e-01
NIK–>noncanonical NF-kB signaling 46 1.73e-08 -4.80e-01 1.93e-07
Bicarbonate transporters 9 1.27e-02 4.80e-01 4.18e-02
GDP-fucose biosynthesis 6 4.22e-02 -4.79e-01 1.08e-01
Protein localization 157 3.95e-25 -4.78e-01 1.74e-23
Protein repair 6 4.30e-02 -4.77e-01 1.10e-01
Switching of origins to a post-replicative state 79 2.42e-13 -4.76e-01 5.78e-12
Interconversion of nucleotide di- and triphosphates 27 1.87e-05 -4.76e-01 1.29e-04
APC/C-mediated degradation of cell cycle proteins 75 1.10e-12 -4.75e-01 2.45e-11
Regulation of mitotic cell cycle 75 1.10e-12 -4.75e-01 2.45e-11
PRC2 methylates histones and DNA 27 2.00e-05 -4.74e-01 1.35e-04
Degradation of GLI1 by the proteasome 46 2.62e-08 -4.74e-01 2.84e-07
Glucuronidation 9 1.39e-02 -4.73e-01 4.46e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 4.53e-05 -4.71e-01 2.89e-04
Synthesis of PI 5 6.89e-02 4.70e-01 1.56e-01
VLDLR internalisation and degradation 16 1.15e-03 -4.69e-01 5.42e-03
Josephin domain DUBs 10 1.03e-02 -4.68e-01 3.53e-02
MECP2 regulates transcription of neuronal ligands 5 7.02e-02 4.68e-01 1.58e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 7.49e-03 4.66e-01 2.69e-02
Formation of tubulin folding intermediates by CCT/TriC 21 2.24e-04 -4.65e-01 1.26e-03
Base Excision Repair 57 1.25e-09 -4.65e-01 1.71e-08
Processive synthesis on the lagging strand 15 1.84e-03 -4.65e-01 8.06e-03
CYP2E1 reactions 6 4.89e-02 4.64e-01 1.20e-01
Tandem pore domain potassium channels 5 7.29e-02 4.63e-01 1.62e-01
DNA Replication 128 1.61e-19 -4.62e-01 6.23e-18
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.31e-05 -4.62e-01 1.55e-04
Meiotic recombination 37 1.16e-06 -4.62e-01 9.82e-06
Gap-filling DNA repair synthesis and ligation in GG-NER 25 6.99e-05 -4.59e-01 4.33e-04
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.37e-04 -4.59e-01 7.93e-04
Cohesin Loading onto Chromatin 10 1.21e-02 4.58e-01 4.02e-02
Formation of the active cofactor, UDP-glucuronate 5 7.61e-02 -4.58e-01 1.68e-01
RNA Polymerase I Transcription Termination 30 1.42e-05 -4.58e-01 1.01e-04
Regulation of PTEN localization 9 1.78e-02 -4.56e-01 5.46e-02
Telomere Maintenance 78 3.36e-12 -4.56e-01 6.91e-11
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 6.14e-11 -4.55e-01 1.03e-09
APC-Cdc20 mediated degradation of Nek2A 26 5.94e-05 -4.55e-01 3.73e-04
Translesion synthesis by REV1 16 1.66e-03 -4.54e-01 7.42e-03
Synthesis of DNA 108 3.40e-16 -4.54e-01 1.13e-14
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 5.43e-02 -4.54e-01 1.31e-01
Translesion synthesis by POLI 17 1.23e-03 -4.53e-01 5.71e-03
ABC transporter disorders 60 1.30e-09 -4.53e-01 1.77e-08
ATF6 (ATF6-alpha) activates chaperones 12 6.72e-03 -4.52e-01 2.46e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.83e-03 -4.50e-01 8.05e-03
mRNA decay by 3’ to 5’ exoribonuclease 13 4.98e-03 -4.50e-01 1.90e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 1.39e-02 -4.49e-01 4.46e-02
Dectin-1 mediated noncanonical NF-kB signaling 48 7.30e-08 -4.49e-01 7.42e-07
Metabolism of folate and pterines 16 1.89e-03 -4.48e-01 8.30e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 8.25e-02 4.48e-01 1.79e-01
Nectin/Necl trans heterodimerization 5 8.31e-02 4.48e-01 1.80e-01
Condensation of Prophase Chromosomes 27 5.90e-05 -4.47e-01 3.72e-04
Interleukin-18 signaling 6 5.85e-02 4.46e-01 1.38e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.43e-05 -4.44e-01 4.00e-04
Response to metal ions 6 6.00e-02 -4.43e-01 1.40e-01
Reactions specific to the complex N-glycan synthesis pathway 7 4.26e-02 -4.43e-01 1.09e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 4.29e-02 -4.42e-01 1.10e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 4.62e-06 -4.41e-01 3.62e-05
tRNA Aminoacylation 42 7.51e-07 -4.41e-01 6.51e-06
ATF6 (ATF6-alpha) activates chaperone genes 10 1.58e-02 -4.41e-01 4.97e-02
mRNA Splicing - Minor Pathway 50 7.63e-08 -4.39e-01 7.72e-07
Ubiquinol biosynthesis 13 6.20e-03 -4.38e-01 2.29e-02
Formation of the Early Elongation Complex 33 1.33e-05 -4.38e-01 9.59e-05
Formation of the HIV-1 Early Elongation Complex 33 1.33e-05 -4.38e-01 9.59e-05
Somitogenesis 41 1.24e-06 -4.37e-01 1.05e-05
DNA replication initiation 8 3.24e-02 -4.37e-01 8.86e-02
Mitochondrial tRNA aminoacylation 21 5.34e-04 -4.36e-01 2.73e-03
Mismatch Repair 15 3.57e-03 -4.34e-01 1.43e-02
Metabolism of cofactors 25 1.70e-04 -4.34e-01 9.71e-04
Metabolism of amino acids and derivatives 308 2.36e-39 -4.34e-01 1.63e-37
Inactivation of APC/C via direct inhibition of the APC/C complex 21 5.80e-04 -4.34e-01 2.91e-03
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 5.80e-04 -4.34e-01 2.91e-03
Synthesis of wybutosine at G37 of tRNA(Phe) 6 6.61e-02 -4.33e-01 1.51e-01
Interleukin-15 signaling 14 5.01e-03 4.33e-01 1.90e-02
Regulation of RUNX2 expression and activity 54 3.69e-08 -4.33e-01 3.98e-07
Interleukin-7 signaling 21 5.97e-04 4.33e-01 2.97e-03
RUNX1 regulates estrogen receptor mediated transcription 6 6.71e-02 4.32e-01 1.53e-01
Activated NTRK3 signals through PI3K 5 9.47e-02 4.32e-01 1.97e-01
Translesion synthesis by POLK 17 2.07e-03 -4.31e-01 8.90e-03
Interleukin-6 signaling 11 1.33e-02 4.31e-01 4.34e-02
FLT3 signaling by CBL mutants 7 4.87e-02 -4.30e-01 1.20e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 1.88e-02 -4.29e-01 5.71e-02
Interleukin-9 signaling 8 3.59e-02 4.28e-01 9.56e-02
PCNA-Dependent Long Patch Base Excision Repair 21 6.91e-04 -4.28e-01 3.39e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 5.60e-03 -4.28e-01 2.09e-02
Binding and Uptake of Ligands by Scavenger Receptors 94 8.39e-13 -4.27e-01 1.93e-11
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.95e-02 -4.27e-01 5.87e-02
Asymmetric localization of PCP proteins 49 2.37e-07 -4.27e-01 2.23e-06
Telomere Extension By Telomerase 23 3.97e-04 -4.27e-01 2.12e-03
p75NTR recruits signalling complexes 12 1.07e-02 -4.26e-01 3.64e-02
Recognition of DNA damage by PCNA-containing replication complex 30 5.54e-05 -4.25e-01 3.50e-04
RUNX1 regulates transcription of genes involved in WNT signaling 5 9.98e-02 4.25e-01 2.07e-01
B-WICH complex positively regulates rRNA expression 45 8.65e-07 -4.24e-01 7.46e-06
VEGF binds to VEGFR leading to receptor dimerization 5 1.01e-01 -4.24e-01 2.08e-01
VEGF ligand-receptor interactions 5 1.01e-01 -4.24e-01 2.08e-01
Fatty acids 6 7.23e-02 4.24e-01 1.62e-01
Dual Incision in GG-NER 41 2.66e-06 -4.24e-01 2.15e-05
Budding and maturation of HIV virion 26 1.91e-04 -4.23e-01 1.08e-03
Interleukin receptor SHC signaling 23 4.55e-04 4.22e-01 2.39e-03
Chromosome Maintenance 103 1.42e-13 -4.21e-01 3.71e-12
Metabolism of RNA 718 4.27e-83 -4.21e-01 4.13e-80
MECP2 regulates transcription factors 5 1.03e-01 4.21e-01 2.12e-01
Glutathione conjugation 28 1.24e-04 -4.19e-01 7.23e-04
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.63e-02 -4.18e-01 5.09e-02
FCGR activation 76 2.97e-10 -4.18e-01 4.41e-09
Phosphorylation of the APC/C 20 1.28e-03 -4.16e-01 5.90e-03
Regulation of RAS by GAPs 55 1.05e-07 -4.14e-01 1.04e-06
Defects of platelet adhesion to exposed collagen 8 4.25e-02 -4.14e-01 1.09e-01
TYSND1 cleaves peroxisomal proteins 7 5.86e-02 -4.13e-01 1.38e-01
Regulation of Complement cascade 96 2.95e-12 -4.12e-01 6.14e-11
Cellular response to hypoxia 59 4.72e-08 -4.11e-01 4.98e-07
Regulation of RUNX1 Expression and Activity 18 2.54e-03 4.11e-01 1.06e-02
Vitamin B1 (thiamin) metabolism 5 1.12e-01 -4.10e-01 2.27e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 3.32e-02 -4.10e-01 9.01e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.54e-03 -4.10e-01 1.75e-02
Amyloid fiber formation 52 3.21e-07 -4.10e-01 2.95e-06
Termination of translesion DNA synthesis 32 6.07e-05 -4.10e-01 3.78e-04
Regulation of PTEN stability and activity 55 1.51e-07 -4.09e-01 1.43e-06
Apoptotic factor-mediated response 19 2.03e-03 -4.09e-01 8.77e-03
Defective GALNT3 causes HFTC 9 3.42e-02 4.08e-01 9.16e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.12e-02 -4.06e-01 3.77e-02
Pausing and recovery of Tat-mediated HIV elongation 30 1.19e-04 -4.06e-01 6.92e-04
Tat-mediated HIV elongation arrest and recovery 30 1.19e-04 -4.06e-01 6.92e-04
tRNA modification in the nucleus and cytosol 43 4.10e-06 -4.06e-01 3.26e-05
Processing and activation of SUMO 10 2.64e-02 -4.05e-01 7.51e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 4.76e-02 -4.04e-01 1.18e-01
Interleukin-2 signaling 11 2.02e-02 4.04e-01 6.00e-02
Formation of TC-NER Pre-Incision Complex 51 5.81e-07 -4.04e-01 5.14e-06
Specification of primordial germ cells 6 8.64e-02 4.04e-01 1.85e-01
FCERI mediated NF-kB activation 129 2.29e-15 -4.04e-01 7.38e-14
Pexophagy 10 2.74e-02 -4.03e-01 7.71e-02
NoRC negatively regulates rRNA expression 60 8.61e-08 -3.99e-01 8.53e-07
Negative epigenetic regulation of rRNA expression 63 4.30e-08 -3.99e-01 4.57e-07
Complement cascade 100 5.52e-12 -3.99e-01 1.10e-10
Post-chaperonin tubulin folding pathway 18 3.47e-03 -3.98e-01 1.40e-02
Triglyceride biosynthesis 10 2.96e-02 3.97e-01 8.20e-02
Activation of SMO 13 1.31e-02 3.97e-01 4.29e-02
Regulation of CDH19 Expression and Function 6 9.25e-02 3.97e-01 1.94e-01
Signaling by FLT3 fusion proteins 18 3.58e-03 3.96e-01 1.43e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 3.01e-02 3.96e-01 8.32e-02
MASTL Facilitates Mitotic Progression 10 3.07e-02 -3.95e-01 8.46e-02
Sodium/Proton exchangers 7 7.08e-02 3.94e-01 1.59e-01
Erythrocytes take up oxygen and release carbon dioxide 7 7.10e-02 3.94e-01 1.59e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.37e-02 -3.94e-01 6.89e-02
Diseases of branched-chain amino acid catabolism 13 1.39e-02 -3.94e-01 4.46e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 76 2.99e-09 -3.93e-01 3.89e-08
Glycosphingolipid biosynthesis 15 8.40e-03 3.93e-01 2.96e-02
Removal of the Flap Intermediate from the C-strand 17 5.13e-03 -3.92e-01 1.94e-02
eNOS activation 12 1.89e-02 -3.92e-01 5.71e-02
Signaling by FGFR2 IIIa TM 18 4.05e-03 -3.91e-01 1.59e-02
RHO GTPases activate PKNs 46 4.46e-06 -3.91e-01 3.51e-05
Myogenesis 21 1.94e-03 3.91e-01 8.48e-03
Activation of NF-kappaB in B cells 54 7.23e-07 -3.90e-01 6.29e-06
mRNA Capping 29 2.91e-04 -3.89e-01 1.59e-03
Diseases associated with N-glycosylation of proteins 20 2.65e-03 -3.88e-01 1.10e-02
Phenylalanine and tyrosine metabolism 9 4.40e-02 -3.88e-01 1.12e-01
DNA Damage Recognition in GG-NER 38 3.56e-05 -3.87e-01 2.32e-04
Chromatin modifications during the maternal to zygotic transition (MZT) 23 1.32e-03 -3.87e-01 6.05e-03
Downregulation of ERBB4 signaling 8 5.85e-02 -3.86e-01 1.38e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 4.52e-02 -3.85e-01 1.14e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.73e-04 -3.85e-01 4.24e-03
Adenylate cyclase inhibitory pathway 11 2.72e-02 3.84e-01 7.69e-02
STAT3 nuclear events downstream of ALK signaling 11 2.73e-02 3.84e-01 7.71e-02
Prevention of phagosomal-lysosomal fusion 9 4.61e-02 -3.84e-01 1.15e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.69e-05 -3.84e-01 1.18e-04
HIV Transcription Elongation 42 1.69e-05 -3.84e-01 1.18e-04
Tat-mediated elongation of the HIV-1 transcript 42 1.69e-05 -3.84e-01 1.18e-04
Regulation of MITF-M-dependent genes involved in apoptosis 16 7.98e-03 3.83e-01 2.85e-02
Sema4D mediated inhibition of cell attachment and migration 7 7.95e-02 -3.83e-01 1.74e-01
Regulation of CDH11 gene transcription 5 1.39e-01 3.82e-01 2.64e-01
tRNA processing 128 8.36e-14 -3.82e-01 2.31e-12
Formation of Incision Complex in GG-NER 43 1.47e-05 -3.82e-01 1.05e-04
Adherens junctions interactions 41 2.37e-05 3.81e-01 1.58e-04
Lagging Strand Synthesis 20 3.16e-03 -3.81e-01 1.29e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 6.11e-04 -3.81e-01 3.03e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 6.11e-04 -3.81e-01 3.03e-03
Role of LAT2/NTAL/LAB on calcium mobilization 77 7.77e-09 -3.80e-01 9.37e-08
Degradation of cysteine and homocysteine 13 1.79e-02 -3.79e-01 5.47e-02
Protein lipoylation 10 3.81e-02 -3.79e-01 1.00e-01
Presynaptic depolarization and calcium channel opening 8 6.40e-02 3.78e-01 1.47e-01
Noncanonical activation of NOTCH3 8 6.40e-02 -3.78e-01 1.47e-01
Cyclin E associated events during G1/S transition 73 2.31e-08 -3.78e-01 2.53e-07
Nef Mediated CD4 Down-regulation 9 4.98e-02 -3.78e-01 1.22e-01
Cytosolic iron-sulfur cluster assembly 13 1.86e-02 -3.77e-01 5.68e-02
Interleukin-20 family signaling 17 7.21e-03 3.76e-01 2.61e-02
HIV elongation arrest and recovery 32 2.34e-04 -3.76e-01 1.30e-03
Pausing and recovery of HIV elongation 32 2.34e-04 -3.76e-01 1.30e-03
Physiological factors 9 5.10e-02 3.76e-01 1.25e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.61e-08 -3.75e-01 1.81e-07
FGFR2 alternative splicing 25 1.19e-03 -3.74e-01 5.59e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 2.47e-02 -3.74e-01 7.16e-02
Interleukin-6 family signaling 20 3.77e-03 3.74e-01 1.50e-02
N-glycan trimming and elongation in the cis-Golgi 5 1.48e-01 -3.74e-01 2.76e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 9.78e-03 3.73e-01 3.38e-02
RNA Polymerase I Promoter Clearance 64 2.54e-07 -3.72e-01 2.36e-06
RNA Polymerase I Transcription 64 2.54e-07 -3.72e-01 2.36e-06
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.46e-04 -3.72e-01 3.19e-03
Signaling by FGFR4 in disease 11 3.25e-02 3.72e-01 8.86e-02
Synthesis of GDP-mannose 6 1.14e-01 -3.72e-01 2.30e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 1.00e-02 -3.72e-01 3.43e-02
Signaling by LTK 10 4.18e-02 3.72e-01 1.08e-01
SARS-CoV-1-host interactions 95 3.81e-10 -3.72e-01 5.53e-09
mRNA Splicing 211 1.82e-20 -3.70e-01 7.18e-19
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 9.08e-02 3.69e-01 1.92e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 8.44e-03 -3.69e-01 2.97e-02
Processive synthesis on the C-strand of the telomere 19 5.45e-03 -3.68e-01 2.04e-02
Azathioprine ADME 21 3.48e-03 -3.68e-01 1.40e-02
IkBA variant leads to EDA-ID 7 9.16e-02 3.68e-01 1.93e-01
G2/M Checkpoints 126 1.05e-12 -3.67e-01 2.38e-11
PERK regulates gene expression 30 5.28e-04 -3.66e-01 2.71e-03
Lipophagy 7 9.41e-02 -3.65e-01 1.97e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 9.41e-02 3.65e-01 1.97e-01
Platelet degranulation 106 8.22e-11 -3.65e-01 1.31e-09
Sulfur amino acid metabolism 23 2.46e-03 -3.65e-01 1.04e-02
RUNX3 Regulates Immune Response and Cell Migration 6 1.22e-01 3.64e-01 2.41e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.94e-02 3.63e-01 8.16e-02
G1/S Transition 120 6.22e-12 -3.63e-01 1.23e-10
RNA Polymerase III Transcription Initiation 36 1.63e-04 -3.63e-01 9.29e-04
Diseases of programmed cell death 58 1.73e-06 -3.63e-01 1.42e-05
Formation of HIV elongation complex in the absence of HIV Tat 44 3.14e-05 -3.63e-01 2.06e-04
Purine catabolism 16 1.21e-02 -3.62e-01 4.02e-02
Receptor Mediated Mitophagy 11 3.77e-02 -3.62e-01 9.94e-02
mRNA Splicing - Major Pathway 203 6.36e-19 -3.61e-01 2.41e-17
Signaling by Erythropoietin 24 2.19e-03 3.61e-01 9.37e-03
Class I peroxisomal membrane protein import 20 5.20e-03 -3.61e-01 1.96e-02
Metabolism of nucleotides 85 8.96e-09 -3.61e-01 1.05e-07
Response to elevated platelet cytosolic Ca2+ 110 6.38e-11 -3.60e-01 1.05e-09
Synthesis of PIPs at the ER membrane 5 1.63e-01 3.60e-01 2.94e-01
Translesion Synthesis by POLH 18 8.17e-03 -3.60e-01 2.90e-02
APOBEC3G mediated resistance to HIV-1 infection 5 1.65e-01 -3.59e-01 2.95e-01
Selective autophagy 77 5.19e-08 -3.59e-01 5.45e-07
Resolution of Abasic Sites (AP sites) 38 1.32e-04 -3.58e-01 7.67e-04
p75NTR negatively regulates cell cycle via SC1 5 1.65e-01 -3.58e-01 2.97e-01
Intrinsic Pathway of Fibrin Clot Formation 15 1.65e-02 -3.58e-01 5.13e-02
RNA Polymerase III Abortive And Retractive Initiation 41 7.42e-05 -3.58e-01 4.55e-04
RNA Polymerase III Transcription 41 7.42e-05 -3.58e-01 4.55e-04
Ras activation upon Ca2+ influx through NMDA receptor 18 8.64e-03 3.58e-01 3.03e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.55e-08 -3.57e-01 1.75e-07
Signaling by ALK 24 2.49e-03 3.57e-01 1.05e-02
Wax and plasmalogen biosynthesis 5 1.68e-01 -3.56e-01 2.99e-01
Dual incision in TC-NER 63 1.02e-06 -3.56e-01 8.70e-06
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 9.49e-06 -3.55e-01 7.00e-05
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.66e-03 -3.54e-01 1.10e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.20e-02 3.54e-01 1.08e-01
Nucleotide biosynthesis 12 3.38e-02 -3.54e-01 9.09e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 62 1.45e-06 -3.54e-01 1.20e-05
Cyclin A:Cdk2-associated events at S phase entry 75 1.21e-07 -3.53e-01 1.19e-06
DNA Damage/Telomere Stress Induced Senescence 42 7.51e-05 -3.53e-01 4.59e-04
Type I hemidesmosome assembly 8 8.44e-02 3.52e-01 1.82e-01
ER-Phagosome pathway 75 1.47e-07 -3.51e-01 1.40e-06
PCP/CE pathway 75 1.48e-07 -3.51e-01 1.40e-06
Maturation of hRSV A proteins 13 2.87e-02 -3.50e-01 8.05e-02
Alternative complement activation 5 1.75e-01 -3.50e-01 3.10e-01
Heme degradation 11 4.48e-02 -3.49e-01 1.13e-01
Glycogen synthesis 11 4.48e-02 -3.49e-01 1.13e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 9.67e-04 -3.48e-01 4.68e-03
Extension of Telomeres 51 1.73e-05 -3.48e-01 1.21e-04
Regulation of MECP2 expression and activity 29 1.23e-03 3.47e-01 5.71e-03
DNA Damage Reversal 8 8.97e-02 -3.46e-01 1.90e-01
Defective GALNT12 causes CRCS1 9 7.27e-02 3.45e-01 1.62e-01
Condensation of Prometaphase Chromosomes 11 4.73e-02 -3.45e-01 1.17e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 7.76e-03 -3.44e-01 2.78e-02
Ribavirin ADME 11 4.86e-02 -3.43e-01 1.20e-01
Incretin synthesis, secretion, and inactivation 14 2.63e-02 -3.43e-01 7.50e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 2.63e-02 -3.43e-01 7.50e-02
Cytochrome c-mediated apoptotic response 13 3.23e-02 -3.43e-01 8.85e-02
Signaling by NOTCH4 70 7.02e-07 -3.43e-01 6.14e-06
Paracetamol ADME 19 1.00e-02 -3.41e-01 3.44e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 3.33e-02 -3.41e-01 9.01e-02
HIV Transcription Initiation 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II HIV Promoter Escape 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Promoter Escape 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Transcription Initiation 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 7.97e-05 -3.40e-01 4.75e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 7.97e-05 -3.40e-01 4.75e-04
Interleukin-2 family signaling 38 3.02e-04 3.39e-01 1.63e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.51e-01 3.38e-01 2.81e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 1.52e-01 3.38e-01 2.82e-01
Defective HLCS causes multiple carboxylase deficiency 7 1.22e-01 -3.38e-01 2.41e-01
PTK6 Regulates Cell Cycle 6 1.52e-01 -3.38e-01 2.82e-01
Lysosome Vesicle Biogenesis 32 9.98e-04 -3.36e-01 4.81e-03
Activation of the pre-replicative complex 32 1.01e-03 -3.36e-01 4.87e-03
Mitotic Telophase/Cytokinesis 13 3.63e-02 3.35e-01 9.64e-02
Aryl hydrocarbon receptor signalling 6 1.56e-01 -3.34e-01 2.85e-01
HDL assembly 6 1.56e-01 3.34e-01 2.85e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 3.84e-03 -3.34e-01 1.52e-02
Glycosphingolipid catabolism 31 1.32e-03 -3.33e-01 6.06e-03
Nef and signal transduction 8 1.03e-01 3.33e-01 2.11e-01
Peroxisomal protein import 58 1.13e-05 -3.33e-01 8.33e-05
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.46e-02 -3.33e-01 4.62e-02
Leading Strand Synthesis 14 3.17e-02 -3.32e-01 8.69e-02
Polymerase switching 14 3.17e-02 -3.32e-01 8.69e-02
FGFR2 mutant receptor activation 23 5.90e-03 -3.32e-01 2.19e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 2.01e-03 -3.31e-01 8.76e-03
The activation of arylsulfatases 10 6.97e-02 -3.31e-01 1.57e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.80e-02 -3.30e-01 1.19e-01
Inactivation of CDC42 and RAC1 7 1.31e-01 -3.29e-01 2.54e-01
Nucleotide Excision Repair 108 3.42e-09 -3.29e-01 4.31e-08
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 1.32e-01 3.29e-01 2.55e-01
RNA Polymerase II Transcription Termination 66 3.99e-06 -3.28e-01 3.18e-05
Senescence-Associated Secretory Phenotype (SASP) 65 4.75e-06 -3.28e-01 3.70e-05
Recycling of bile acids and salts 10 7.26e-02 3.28e-01 1.62e-01
PI3K events in ERBB2 signaling 11 5.98e-02 3.28e-01 1.39e-01
DNA strand elongation 32 1.35e-03 -3.27e-01 6.16e-03
Processing of Capped Intron-Containing Pre-mRNA 279 5.48e-21 -3.27e-01 2.25e-19
Branched-chain amino acid catabolism 21 9.57e-03 -3.27e-01 3.33e-02
NOTCH2 intracellular domain regulates transcription 11 6.07e-02 3.27e-01 1.41e-01
Advanced glycosylation endproduct receptor signaling 12 5.03e-02 -3.26e-01 1.23e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 1.67e-02 3.26e-01 5.19e-02
Aggrephagy 34 1.02e-03 -3.25e-01 4.90e-03
SHC-related events triggered by IGF1R 8 1.11e-01 3.25e-01 2.25e-01
ABC-family proteins mediated transport 81 4.17e-07 -3.25e-01 3.80e-06
Transcription of the HIV genome 67 4.16e-06 -3.25e-01 3.30e-05
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.27e-04 -3.25e-01 2.71e-03
Urea cycle 7 1.37e-01 -3.25e-01 2.60e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 3.22e-07 -3.24e-01 2.95e-06
Disorders of Developmental Biology 12 5.22e-02 3.24e-01 1.26e-01
Disorders of Nervous System Development 12 5.22e-02 3.24e-01 1.26e-01
Loss of function of MECP2 in Rett syndrome 12 5.22e-02 3.24e-01 1.26e-01
Pervasive developmental disorders 12 5.22e-02 3.24e-01 1.26e-01
Signaling by BMP 23 7.28e-03 3.23e-01 2.64e-02
Regulation of gene expression in beta cells 8 1.14e-01 3.23e-01 2.30e-01
Mitotic G1 phase and G1/S transition 138 6.22e-11 -3.22e-01 1.04e-09
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 1.41e-01 3.21e-01 2.67e-01
Transport of nucleotide sugars 9 9.57e-02 -3.21e-01 1.99e-01
DCC mediated attractive signaling 13 4.54e-02 -3.20e-01 1.14e-01
Vitamin C (ascorbate) metabolism 8 1.17e-01 3.20e-01 2.33e-01
Positive epigenetic regulation of rRNA expression 60 1.82e-05 -3.20e-01 1.26e-04
E3 ubiquitin ligases ubiquitinate target proteins 51 7.77e-05 -3.20e-01 4.73e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.06e-03 -3.20e-01 5.07e-03
Role of phospholipids in phagocytosis 88 2.27e-07 -3.19e-01 2.14e-06
Interleukin-10 signaling 38 6.68e-04 3.19e-01 3.28e-03
Diseases of Mismatch Repair (MMR) 5 2.17e-01 -3.19e-01 3.61e-01
Late endosomal microautophagy 30 2.55e-03 -3.18e-01 1.06e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.45e-01 3.18e-01 2.73e-01
S Phase 150 1.77e-11 -3.18e-01 3.17e-10
RHO GTPases Activate Rhotekin and Rhophilins 8 1.20e-01 -3.17e-01 2.38e-01
Activation of BAD and translocation to mitochondria 15 3.33e-02 -3.17e-01 9.01e-02
FCERI mediated MAPK activation 93 1.44e-07 -3.15e-01 1.39e-06
Defective factor IX causes hemophilia B 6 1.82e-01 -3.15e-01 3.18e-01
Processing of Capped Intronless Pre-mRNA 29 3.34e-03 -3.15e-01 1.36e-02
Propionyl-CoA catabolism 5 2.24e-01 -3.14e-01 3.70e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.52e-02 -3.14e-01 7.25e-02
Chaperone Mediated Autophagy 20 1.55e-02 -3.12e-01 4.88e-02
Axonal growth inhibition (RHOA activation) 7 1.53e-01 -3.12e-01 2.83e-01
p75NTR regulates axonogenesis 7 1.53e-01 -3.12e-01 2.83e-01
Nuclear events mediated by NFE2L2 82 1.02e-06 -3.12e-01 8.70e-06
FCGR3A-mediated phagocytosis 121 3.02e-09 -3.12e-01 3.89e-08
Leishmania phagocytosis 121 3.02e-09 -3.12e-01 3.89e-08
Parasite infection 121 3.02e-09 -3.12e-01 3.89e-08
Signaling by WNT in cancer 30 3.10e-03 3.12e-01 1.27e-02
Myoclonic epilepsy of Lafora 8 1.27e-01 -3.12e-01 2.48e-01
Regulation of IFNA/IFNB signaling 12 6.21e-02 3.11e-01 1.43e-01
Cell Cycle Checkpoints 246 4.18e-17 -3.11e-01 1.42e-15
NFE2L2 regulating ER-stress associated genes 5 2.29e-01 3.11e-01 3.75e-01
SMAC (DIABLO) binds to IAPs 7 1.55e-01 -3.11e-01 2.84e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.55e-01 -3.11e-01 2.84e-01
SMAC, XIAP-regulated apoptotic response 7 1.55e-01 -3.11e-01 2.84e-01
HIV Infection 213 5.48e-15 -3.10e-01 1.74e-13
UCH proteinases 73 4.52e-06 -3.10e-01 3.55e-05
NF-kB is activated and signals survival 12 6.28e-02 -3.10e-01 1.45e-01
ABC transporters in lipid homeostasis 14 4.48e-02 3.10e-01 1.13e-01
Heme signaling 45 3.38e-04 3.09e-01 1.81e-03
Signaling by the B Cell Receptor (BCR) 150 7.64e-11 -3.08e-01 1.24e-09
Insulin receptor recycling 24 9.09e-03 -3.08e-01 3.18e-02
Aflatoxin activation and detoxification 14 4.67e-02 -3.07e-01 1.16e-01
Pregnenolone biosynthesis 10 9.28e-02 -3.07e-01 1.94e-01
Diseases associated with glycosylation precursor biosynthesis 15 3.96e-02 -3.07e-01 1.03e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 1.60e-01 3.07e-01 2.91e-01
Early Phase of HIV Life Cycle 14 4.71e-02 -3.06e-01 1.17e-01
Host Interactions of HIV factors 118 9.28e-09 -3.06e-01 1.07e-07
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.91e-02 -3.06e-01 8.14e-02
SARS-CoV-1 Infection 138 6.00e-10 -3.05e-01 8.52e-09
DNA Damage Bypass 47 2.96e-04 -3.05e-01 1.61e-03
Polo-like kinase mediated events 16 3.47e-02 -3.05e-01 9.27e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.14e-01 -3.04e-01 2.30e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 2.39e-01 -3.04e-01 3.90e-01
Retrograde neurotrophin signalling 12 6.95e-02 -3.03e-01 1.57e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 9.77e-02 3.02e-01 2.02e-01
FCERI mediated Ca+2 mobilization 92 5.45e-07 -3.02e-01 4.86e-06
Germ layer formation at gastrulation 9 1.17e-01 3.02e-01 2.33e-01
O-glycosylation of TSR domain-containing proteins 28 5.75e-03 3.02e-01 2.14e-02
Separation of Sister Chromatids 168 1.52e-11 -3.01e-01 2.75e-10
Mitotic Anaphase 211 4.80e-14 -3.01e-01 1.40e-12
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.44e-01 3.01e-01 3.95e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 4.40e-02 -3.00e-01 1.12e-01
Signal transduction by L1 20 2.01e-02 -3.00e-01 5.98e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 5.18e-02 -3.00e-01 1.26e-01
Mitotic Metaphase and Anaphase 212 4.85e-14 -3.00e-01 1.40e-12
Macroautophagy 128 5.30e-09 -2.99e-01 6.56e-08
Spry regulation of FGF signaling 16 3.87e-02 -2.99e-01 1.02e-01
Defective B3GALTL causes PpS 27 7.37e-03 2.98e-01 2.66e-02
Prostanoid ligand receptors 8 1.45e-01 -2.98e-01 2.72e-01
Nucleotide catabolism 28 6.45e-03 -2.97e-01 2.37e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 4.64e-02 2.97e-01 1.16e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.08e-01 2.97e-01 3.49e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 2.08e-01 -2.97e-01 3.49e-01
Estrogen-stimulated signaling through PRKCZ 6 2.08e-01 -2.97e-01 3.49e-01
Pyrimidine salvage 10 1.05e-01 -2.96e-01 2.15e-01
Transport of RCbl within the body 8 1.47e-01 -2.96e-01 2.76e-01
Beta-oxidation of pristanoyl-CoA 9 1.24e-01 -2.96e-01 2.44e-01
RUNX3 regulates NOTCH signaling 14 5.56e-02 2.95e-01 1.33e-01
IRAK1 recruits IKK complex 14 5.67e-02 -2.94e-01 1.35e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 5.67e-02 -2.94e-01 1.35e-01
Initiation of Nuclear Envelope (NE) Reformation 19 2.65e-02 -2.94e-01 7.54e-02
Reversal of alkylation damage by DNA dioxygenases 7 1.79e-01 -2.93e-01 3.15e-01
RHOBTB1 GTPase cycle 23 1.49e-02 -2.93e-01 4.69e-02
Regulation of actin dynamics for phagocytic cup formation 123 1.91e-08 -2.93e-01 2.12e-07
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 5.45e-03 -2.93e-01 2.04e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 2.02e-02 -2.93e-01 6.00e-02
Neurodegenerative Diseases 21 2.02e-02 -2.93e-01 6.00e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 4.27e-03 -2.92e-01 1.66e-02
RAS processing 23 1.55e-02 -2.92e-01 4.87e-02
Nef Mediated CD8 Down-regulation 7 1.82e-01 -2.92e-01 3.18e-01
Activation of caspases through apoptosome-mediated cleavage 6 2.17e-01 -2.91e-01 3.60e-01
Regulation of BACH1 activity 11 9.44e-02 -2.91e-01 1.97e-01
Glutathione synthesis and recycling 10 1.11e-01 -2.91e-01 2.25e-01
Transcriptional regulation of pluripotent stem cells 21 2.13e-02 2.90e-01 6.26e-02
E2F-enabled inhibition of pre-replication complex formation 9 1.33e-01 -2.89e-01 2.57e-01
CD209 (DC-SIGN) signaling 20 2.53e-02 2.89e-01 7.25e-02
Activation of Ca-permeable Kainate Receptor 9 1.34e-01 2.88e-01 2.57e-01
Ionotropic activity of kainate receptors 9 1.34e-01 2.88e-01 2.57e-01
Downstream signaling events of B Cell Receptor (BCR) 68 4.02e-05 -2.88e-01 2.59e-04
HCMV Late Events 67 4.69e-05 -2.88e-01 2.98e-04
GP1b-IX-V activation signalling 12 8.51e-02 -2.87e-01 1.83e-01
Regulation of innate immune responses to cytosolic DNA 14 6.31e-02 -2.87e-01 1.45e-01
Nuclear Envelope (NE) Reassembly 68 4.46e-05 -2.86e-01 2.85e-04
Transcriptional regulation of testis differentiation 5 2.68e-01 2.86e-01 4.22e-01
Formation of paraxial mesoderm 52 3.72e-04 -2.85e-01 1.99e-03
Membrane binding and targetting of GAG proteins 13 7.51e-02 -2.85e-01 1.66e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 7.51e-02 -2.85e-01 1.66e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.37e-02 2.85e-01 4.41e-02
Late Phase of HIV Life Cycle 131 2.00e-08 -2.84e-01 2.21e-07
Telomere C-strand (Lagging Strand) Synthesis 34 4.25e-03 -2.83e-01 1.66e-02
TNFR1-mediated ceramide production 6 2.30e-01 -2.83e-01 3.77e-01
Transcriptional regulation by small RNAs 61 1.35e-04 -2.83e-01 7.81e-04
Activation of RAS in B cells 5 2.74e-01 2.83e-01 4.29e-01
mTORC1-mediated signalling 24 1.67e-02 -2.82e-01 5.19e-02
Interaction between L1 and Ankyrins 26 1.28e-02 2.82e-01 4.20e-02
Smooth Muscle Contraction 34 4.45e-03 -2.82e-01 1.72e-02
Viral Infection Pathways 776 7.76e-41 -2.82e-01 6.82e-39
HIV Life Cycle 144 5.41e-09 -2.82e-01 6.66e-08
Regulation of PTEN mRNA translation 13 7.90e-02 2.81e-01 1.73e-01
Nuclear Receptor transcription pathway 40 2.08e-03 2.81e-01 8.91e-03
MyD88 deficiency (TLR2/4) 14 6.86e-02 2.81e-01 1.56e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 6.87e-02 -2.81e-01 1.56e-01
Phase 4 - resting membrane potential 9 1.44e-01 2.81e-01 2.72e-01
Diseases of Base Excision Repair 5 2.78e-01 -2.80e-01 4.34e-01
Cholesterol biosynthesis 26 1.36e-02 -2.80e-01 4.39e-02
Acetylcholine binding and downstream events 5 2.79e-01 2.80e-01 4.34e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.79e-01 2.80e-01 4.34e-01
Infection with Mycobacterium tuberculosis 26 1.39e-02 -2.79e-01 4.46e-02
Autophagy 142 9.69e-09 -2.79e-01 1.11e-07
mRNA 3’-end processing 57 2.79e-04 -2.78e-01 1.53e-03
Assembly Of The HIV Virion 15 6.21e-02 -2.78e-01 1.43e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 1.43e-03 2.78e-01 6.45e-03
Cyclin A/B1/B2 associated events during G2/M transition 25 1.62e-02 -2.78e-01 5.07e-02
Voltage gated Potassium channels 26 1.45e-02 2.77e-01 4.60e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.21e-02 -2.77e-01 8.80e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 9.70e-02 -2.77e-01 2.01e-01
Metabolism of non-coding RNA 53 4.97e-04 -2.76e-01 2.57e-03
snRNP Assembly 53 4.97e-04 -2.76e-01 2.57e-03
2-LTR circle formation 7 2.05e-01 -2.76e-01 3.48e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 6.01e-03 2.76e-01 2.22e-02
TRAIL signaling 8 1.76e-01 2.76e-01 3.11e-01
Synaptic adhesion-like molecules 17 4.90e-02 2.76e-01 1.21e-01
TRP channels 22 2.54e-02 2.75e-01 7.26e-02
Protein ubiquitination 71 6.05e-05 -2.75e-01 3.78e-04
Cellular responses to stress 698 2.47e-35 -2.75e-01 1.33e-33
Transport of vitamins, nucleosides, and related molecules 32 7.18e-03 -2.75e-01 2.61e-02
Interleukin-1 processing 8 1.79e-01 2.74e-01 3.15e-01
SARS-CoV-2 modulates autophagy 11 1.16e-01 -2.74e-01 2.32e-01
NFE2L2 regulating tumorigenic genes 11 1.16e-01 2.74e-01 2.32e-01
Protein folding 83 1.67e-05 -2.73e-01 1.18e-04
Transcriptional Regulation by NPAS4 27 1.40e-02 2.73e-01 4.47e-02
Antigen processing-Cross presentation 89 8.68e-06 -2.73e-01 6.50e-05
Defective Intrinsic Pathway for Apoptosis 24 2.08e-02 -2.73e-01 6.14e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 1.57e-01 2.72e-01 2.87e-01
Negative feedback regulation of MAPK pathway 6 2.50e-01 -2.71e-01 4.02e-01
Processing of DNA double-strand break ends 69 1.00e-04 -2.71e-01 5.89e-04
Caspase activation via Death Receptors in the presence of ligand 16 6.14e-02 2.70e-01 1.42e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.05e-06 -2.69e-01 1.67e-05
Defective C1GALT1C1 causes TNPS 10 1.41e-01 2.69e-01 2.67e-01
EGFR interacts with phospholipase C-gamma 7 2.18e-01 2.69e-01 3.62e-01
Regulation of beta-cell development 22 2.92e-02 2.69e-01 8.16e-02
Integration of provirus 9 1.63e-01 -2.69e-01 2.94e-01
MECP2 regulates neuronal receptors and channels 14 8.23e-02 2.68e-01 1.79e-01
Degradation of beta-catenin by the destruction complex 72 8.50e-05 -2.68e-01 5.05e-04
Phase II - Conjugation of compounds 71 9.63e-05 -2.68e-01 5.67e-04
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.10e-01 -2.67e-01 2.23e-01
Transport of connexons to the plasma membrane 12 1.10e-01 -2.67e-01 2.23e-01
Amine ligand-binding receptors 10 1.44e-01 2.67e-01 2.72e-01
Diseases associated with the TLR signaling cascade 29 1.30e-02 2.67e-01 4.24e-02
Diseases of Immune System 29 1.30e-02 2.67e-01 4.24e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.93e-01 -2.66e-01 3.33e-01
Syndecan interactions 26 1.94e-02 -2.65e-01 5.86e-02
Formation of apoptosome 11 1.29e-01 -2.65e-01 2.50e-01
Regulation of the apoptosome activity 11 1.29e-01 -2.65e-01 2.50e-01
Neurexins and neuroligins 40 3.81e-03 2.64e-01 1.51e-02
Synthesis of PIPs at the plasma membrane 52 9.75e-04 2.64e-01 4.71e-03
Homology Directed Repair 110 1.67e-06 -2.64e-01 1.38e-05
Polymerase switching on the C-strand of the telomere 26 1.99e-02 -2.64e-01 5.95e-02
Glyoxylate metabolism and glycine degradation 13 1.00e-01 -2.63e-01 2.07e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.65e-01 -2.63e-01 4.19e-01
IL-6-type cytokine receptor ligand interactions 13 1.03e-01 2.61e-01 2.12e-01
Platelet Aggregation (Plug Formation) 30 1.33e-02 -2.61e-01 4.34e-02
Scavenging by Class A Receptors 14 9.11e-02 -2.61e-01 1.92e-01
HCMV Infection 106 3.81e-06 -2.60e-01 3.06e-05
TRAF3-dependent IRF activation pathway 13 1.05e-01 2.60e-01 2.15e-01
LGI-ADAM interactions 9 1.78e-01 2.60e-01 3.13e-01
Fructose catabolism 5 3.15e-01 -2.60e-01 4.71e-01
Suppression of phagosomal maturation 12 1.20e-01 -2.59e-01 2.38e-01
Signaling by MST1 5 3.17e-01 -2.58e-01 4.72e-01
Amino acids regulate mTORC1 48 1.98e-03 -2.58e-01 8.63e-03
CLEC7A (Dectin-1) induces NFAT activation 11 1.39e-01 2.58e-01 2.64e-01
Metabolism of proteins 1777 7.49e-73 -2.57e-01 4.82e-70
IRAK4 deficiency (TLR2/4) 15 8.55e-02 2.56e-01 1.84e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.09e-01 2.56e-01 3.50e-01
Regulation of signaling by CBL 22 3.77e-02 2.56e-01 9.95e-02
Metabolism of porphyrins 23 3.37e-02 -2.56e-01 9.08e-02
Activation of NOXA and translocation to mitochondria 5 3.22e-01 2.56e-01 4.78e-01
Cellular responses to stimuli 779 5.49e-34 -2.56e-01 2.79e-32
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.62e-01 -2.55e-01 2.94e-01
TGFBR3 PTM regulation 10 1.63e-01 -2.55e-01 2.94e-01
Association of TriC/CCT with target proteins during biosynthesis 35 9.12e-03 -2.55e-01 3.18e-02
Maturation of spike protein 9694548 36 8.27e-03 -2.54e-01 2.93e-02
Phosphorylation of Emi1 6 2.82e-01 -2.54e-01 4.36e-01
PTK6 promotes HIF1A stabilization 6 2.82e-01 2.54e-01 4.36e-01
trans-Golgi Network Vesicle Budding 69 2.67e-04 -2.54e-01 1.48e-03
tRNA processing in the nucleus 59 7.71e-04 -2.53e-01 3.76e-03
KEAP1-NFE2L2 pathway 107 6.10e-06 -2.53e-01 4.71e-05
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 2.47e-01 2.53e-01 3.98e-01
Fc epsilon receptor (FCERI) signaling 179 5.58e-09 -2.52e-01 6.83e-08
Cell surface interactions at the vascular wall 176 8.02e-09 -2.52e-01 9.50e-08
Methylation 13 1.16e-01 -2.52e-01 2.32e-01
Activation of RAC1 downstream of NMDARs 7 2.49e-01 -2.52e-01 4.01e-01
Signaling by ERBB2 KD Mutants 20 5.15e-02 2.51e-01 1.26e-01
Transcriptional regulation by RUNX2 92 3.06e-05 -2.51e-01 2.03e-04
Formation of axial mesoderm 6 2.87e-01 2.51e-01 4.42e-01
Unfolded Protein Response (UPR) 84 7.02e-05 -2.51e-01 4.33e-04
NFE2L2 regulates pentose phosphate pathway genes 8 2.20e-01 2.51e-01 3.64e-01
MicroRNA (miRNA) biogenesis 24 3.37e-02 -2.50e-01 9.08e-02
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 3.33e-01 -2.50e-01 4.90e-01
MAPK6/MAPK4 signaling 69 3.32e-04 -2.50e-01 1.79e-03
Ca2+ activated K+ channels 6 2.90e-01 -2.50e-01 4.45e-01
RMTs methylate histone arginines 35 1.06e-02 -2.49e-01 3.63e-02
TNFR2 non-canonical NF-kB pathway 84 7.78e-05 -2.49e-01 4.73e-04
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.36e-01 2.49e-01 2.59e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 8.51e-02 -2.49e-01 1.83e-01
TNFR1-induced proapoptotic signaling 24 3.53e-02 2.48e-01 9.40e-02
Chondroitin sulfate biosynthesis 12 1.37e-01 2.48e-01 2.60e-01
FCGR3A-mediated IL10 synthesis 99 1.98e-05 -2.48e-01 1.35e-04
Nucleotide salvage 21 4.91e-02 -2.48e-01 1.21e-01
HDR through Homologous Recombination (HRR) 68 4.04e-04 -2.48e-01 2.15e-03
Activation of ATR in response to replication stress 37 9.07e-03 -2.48e-01 3.18e-02
CASP8 activity is inhibited 11 1.55e-01 2.48e-01 2.84e-01
Dimerization of procaspase-8 11 1.55e-01 2.48e-01 2.84e-01
Regulation by c-FLIP 11 1.55e-01 2.48e-01 2.84e-01
Diseases of hemostasis 15 9.69e-02 -2.48e-01 2.01e-01
G1/S-Specific Transcription 29 2.12e-02 -2.47e-01 6.25e-02
Mitotic G2-G2/M phases 179 1.17e-08 -2.47e-01 1.34e-07
NrCAM interactions 6 2.95e-01 2.47e-01 4.51e-01
PI-3K cascade:FGFR4 11 1.56e-01 2.47e-01 2.85e-01
Calnexin/calreticulin cycle 26 2.93e-02 -2.47e-01 8.16e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.10e-01 -2.47e-01 2.23e-01
Miro GTPase Cycle 8 2.27e-01 -2.47e-01 3.73e-01
CREB3 factors activate genes 6 2.98e-01 -2.46e-01 4.54e-01
G2/M DNA damage checkpoint 66 5.67e-04 -2.45e-01 2.88e-03
Negative regulation of FGFR3 signaling 21 5.18e-02 -2.45e-01 1.26e-01
Diseases associated with O-glycosylation of proteins 50 2.79e-03 2.44e-01 1.15e-02
HSF1 activation 26 3.13e-02 -2.44e-01 8.61e-02
NCAM1 interactions 27 2.85e-02 2.44e-01 8.00e-02
Endosomal/Vacuolar pathway 12 1.44e-01 -2.43e-01 2.72e-01
G2/M Transition 177 2.34e-08 -2.43e-01 2.56e-07
p75NTR signals via NF-kB 15 1.03e-01 -2.43e-01 2.12e-01
Chaperonin-mediated protein folding 77 2.28e-04 -2.43e-01 1.28e-03
Signaling by NTRK3 (TRKC) 16 9.27e-02 2.43e-01 1.94e-01
Defects in biotin (Btn) metabolism 8 2.34e-01 -2.43e-01 3.84e-01
RNA Polymerase II Pre-transcription Events 77 2.39e-04 -2.42e-01 1.33e-03
Long-term potentiation 18 7.60e-02 2.42e-01 1.68e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.21e-02 2.41e-01 6.49e-02
DNA Repair 289 1.72e-12 -2.41e-01 3.68e-11
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 9.43e-03 2.40e-01 3.28e-02
PI-3K cascade:FGFR2 13 1.34e-01 2.40e-01 2.57e-01
Mitotic Spindle Checkpoint 108 1.67e-05 -2.40e-01 1.18e-04
RHOBTB GTPase Cycle 35 1.42e-02 -2.40e-01 4.51e-02
Infectious disease 959 2.85e-36 -2.39e-01 1.58e-34
ZBP1(DAI) mediated induction of type I IFNs 20 6.43e-02 2.39e-01 1.47e-01
Deadenylation-dependent mRNA decay 50 3.49e-03 -2.39e-01 1.40e-02
Role of second messengers in netrin-1 signaling 6 3.12e-01 2.39e-01 4.69e-01
Class B/2 (Secretin family receptors) 55 2.22e-03 2.38e-01 9.46e-03
Thyroxine biosynthesis 5 3.56e-01 2.38e-01 5.14e-01
Interleukin-37 signaling 19 7.21e-02 2.38e-01 1.61e-01
Detoxification of Reactive Oxygen Species 30 2.39e-02 -2.38e-01 6.94e-02
MAP2K and MAPK activation 36 1.34e-02 -2.38e-01 4.35e-02
Diseases of carbohydrate metabolism 29 2.66e-02 -2.38e-01 7.54e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.24e-01 2.37e-01 2.44e-01
Unwinding of DNA 12 1.55e-01 -2.37e-01 2.84e-01
Sphingolipid de novo biosynthesis 34 1.68e-02 -2.37e-01 5.21e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.54e-03 -2.37e-01 1.75e-02
COPI-independent Golgi-to-ER retrograde traffic 45 6.12e-03 -2.36e-01 2.26e-02
Pyruvate metabolism 44 6.74e-03 -2.36e-01 2.46e-02
Regulation of HMOX1 expression and activity 5 3.61e-01 2.36e-01 5.19e-01
Formation of RNA Pol II elongation complex 56 2.28e-03 -2.36e-01 9.69e-03
RNA Polymerase II Transcription Elongation 56 2.28e-03 -2.36e-01 9.69e-03
RUNX3 regulates p14-ARF 10 1.97e-01 2.36e-01 3.39e-01
Nephrin family interactions 20 6.82e-02 2.36e-01 1.55e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 5.06e-02 -2.35e-01 1.24e-01
Neddylation 215 2.65e-09 -2.35e-01 3.51e-08
RNA Polymerase I Transcription Initiation 47 5.28e-03 -2.35e-01 1.99e-02
SHC1 events in ERBB4 signaling 10 1.98e-01 2.35e-01 3.39e-01
Phase 0 - rapid depolarisation 24 4.66e-02 2.35e-01 1.16e-01
WNT5A-dependent internalization of FZD4 13 1.43e-01 -2.35e-01 2.70e-01
Expression and translocation of olfactory receptors 56 2.39e-03 2.35e-01 1.01e-02
Cell-cell junction organization 60 1.68e-03 2.34e-01 7.47e-03
PI Metabolism 79 3.14e-04 2.34e-01 1.70e-03
Transport of Mature Transcript to Cytoplasm 81 2.71e-04 -2.34e-01 1.49e-03
Sodium/Calcium exchangers 9 2.26e-01 -2.33e-01 3.72e-01
Fructose metabolism 7 2.89e-01 -2.32e-01 4.45e-01
Intrinsic Pathway for Apoptosis 54 3.31e-03 -2.31e-01 1.35e-02
NFE2L2 regulating MDR associated enzymes 8 2.58e-01 2.31e-01 4.10e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.10e-01 -2.31e-01 2.23e-01
Signaling by high-kinase activity BRAF mutants 33 2.17e-02 -2.31e-01 6.38e-02
BBSome-mediated cargo-targeting to cilium 22 6.12e-02 -2.31e-01 1.42e-01
Downstream signaling of activated FGFR4 18 9.12e-02 2.30e-01 1.93e-01
Hyaluronan uptake and degradation 12 1.68e-01 -2.30e-01 3.00e-01
Meiosis 67 1.14e-03 -2.30e-01 5.40e-03
Xenobiotics 12 1.69e-01 2.30e-01 3.01e-01
Gluconeogenesis 19 8.33e-02 -2.29e-01 1.80e-01
Downstream signaling of activated FGFR1 22 6.26e-02 2.29e-01 1.44e-01
DNA Double-Strand Break Repair 137 3.60e-06 -2.29e-01 2.90e-05
Transcriptional Regulation by MECP2 49 5.52e-03 2.29e-01 2.07e-02
HCMV Early Events 84 2.83e-04 -2.29e-01 1.55e-03
M Phase 346 2.39e-13 -2.29e-01 5.77e-12
TP53 Regulates Metabolic Genes 78 4.87e-04 -2.28e-01 2.54e-03
Synthesis of bile acids and bile salts 27 4.05e-02 2.28e-01 1.06e-01
Insulin processing 19 8.59e-02 2.28e-01 1.84e-01
Bile acid and bile salt metabolism 31 2.85e-02 2.27e-01 8.00e-02
Downstream signaling of activated FGFR2 20 7.85e-02 2.27e-01 1.72e-01
Basigin interactions 23 5.94e-02 -2.27e-01 1.39e-01
Downstream TCR signaling 89 2.17e-04 -2.27e-01 1.22e-03
Translation of Structural Proteins 9694635 56 3.37e-03 -2.26e-01 1.37e-02
Dissolution of Fibrin Clot 12 1.75e-01 -2.26e-01 3.09e-01
SARS-CoV-2-host interactions 183 1.39e-07 -2.26e-01 1.34e-06
Linoleic acid (LA) metabolism 7 3.01e-01 2.26e-01 4.59e-01
RIP-mediated NFkB activation via ZBP1 17 1.07e-01 2.26e-01 2.19e-01
Termination of O-glycan biosynthesis 16 1.19e-01 2.25e-01 2.36e-01
Synthesis of PIPs at the early endosome membrane 16 1.19e-01 2.25e-01 2.36e-01
Peroxisomal lipid metabolism 27 4.31e-02 -2.25e-01 1.10e-01
PI-3K cascade:FGFR3 10 2.18e-01 2.25e-01 3.62e-01
Anti-inflammatory response favouring Leishmania parasite infection 132 8.12e-06 -2.25e-01 6.13e-05
Leishmania parasite growth and survival 132 8.12e-06 -2.25e-01 6.13e-05
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 4.72e-02 2.25e-01 1.17e-01
ROBO receptors bind AKAP5 7 3.03e-01 2.25e-01 4.60e-01
Olfactory Signaling Pathway 61 2.42e-03 2.25e-01 1.02e-02
Signaling by LTK in cancer 7 3.04e-01 2.24e-01 4.61e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.86e-01 2.24e-01 5.45e-01
MHC class II antigen presentation 113 3.89e-05 -2.24e-01 2.52e-04
Lysosphingolipid and LPA receptors 11 1.99e-01 2.24e-01 3.40e-01
DNA Double Strand Break Response 47 8.06e-03 -2.23e-01 2.87e-02
GAB1 signalosome 15 1.35e-01 2.23e-01 2.59e-01
Dectin-2 family 19 9.28e-02 2.23e-01 1.94e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 3.89e-01 -2.23e-01 5.47e-01
Maple Syrup Urine Disease 5 3.89e-01 -2.23e-01 5.47e-01
RHOBTB3 ATPase cycle 10 2.24e-01 -2.22e-01 3.70e-01
Platelet Adhesion to exposed collagen 16 1.25e-01 -2.22e-01 2.45e-01
Coenzyme A biosynthesis 7 3.10e-01 -2.21e-01 4.67e-01
Neurotransmitter clearance 6 3.48e-01 -2.21e-01 5.06e-01
GABA receptor activation 38 1.83e-02 2.21e-01 5.59e-02
NR1H2 and NR1H3-mediated signaling 39 1.71e-02 2.21e-01 5.28e-02
Metabolism 1835 1.10e-55 -2.21e-01 3.53e-53
Telomere C-strand synthesis initiation 13 1.69e-01 -2.20e-01 3.01e-01
IGF1R signaling cascade 38 1.87e-02 2.20e-01 5.70e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 3.67e-02 -2.20e-01 9.73e-02
IRS-related events triggered by IGF1R 37 2.05e-02 2.20e-01 6.06e-02
Signaling by KIT in disease 20 8.84e-02 2.20e-01 1.88e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 8.84e-02 2.20e-01 1.88e-01
Golgi Associated Vesicle Biogenesis 55 4.78e-03 -2.20e-01 1.83e-02
Apoptosis 158 1.85e-06 -2.20e-01 1.51e-05
RAS signaling downstream of NF1 loss-of-function variants 7 3.15e-01 2.19e-01 4.71e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 1.71e-01 -2.19e-01 3.04e-01
Negative regulation of FGFR1 signaling 25 5.80e-02 -2.19e-01 1.37e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 8.23e-02 -2.19e-01 1.79e-01
Biosynthesis of EPA-derived SPMs 6 3.54e-01 2.19e-01 5.13e-01
Glutamate and glutamine metabolism 12 1.90e-01 -2.19e-01 3.30e-01
Prostacyclin signalling through prostacyclin receptor 16 1.31e-01 -2.18e-01 2.54e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.43e-03 -2.17e-01 6.44e-03
RHOU GTPase cycle 40 1.76e-02 2.17e-01 5.40e-02
Signaling by FGFR3 in disease 14 1.60e-01 2.17e-01 2.91e-01
Synthesis of PIPs at the Golgi membrane 16 1.34e-01 2.16e-01 2.57e-01
Constitutive Signaling by EGFRvIII 14 1.61e-01 2.16e-01 2.93e-01
Signaling by EGFRvIII in Cancer 14 1.61e-01 2.16e-01 2.93e-01
Downstream signaling of activated FGFR3 17 1.23e-01 2.16e-01 2.43e-01
Protein-protein interactions at synapses 61 3.57e-03 2.16e-01 1.43e-02
TRAF6 mediated IRF7 activation 15 1.51e-01 2.14e-01 2.81e-01
Activation of PUMA and translocation to mitochondria 9 2.66e-01 2.14e-01 4.20e-01
Metabolism of steroid hormones 22 8.22e-02 -2.14e-01 1.79e-01
FLT3 signaling through SRC family kinases 6 3.65e-01 2.14e-01 5.22e-01
Purine salvage 12 2.00e-01 -2.14e-01 3.40e-01
SARS-CoV-2 Infection 267 1.87e-09 -2.14e-01 2.51e-08
RHOT2 GTPase cycle 7 3.28e-01 -2.13e-01 4.84e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 1.23e-02 -2.13e-01 4.08e-02
Negative regulation of FGFR4 signaling 22 8.41e-02 -2.13e-01 1.81e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 8.79e-06 -2.12e-01 6.56e-05
Hedgehog ‘on’ state 65 3.13e-03 -2.12e-01 1.28e-02
FGFRL1 modulation of FGFR1 signaling 7 3.32e-01 2.12e-01 4.89e-01
Pyroptosis 25 6.74e-02 -2.11e-01 1.53e-01
Cellular response to chemical stress 179 1.10e-06 -2.11e-01 9.31e-06
Signal attenuation 9 2.74e-01 -2.10e-01 4.29e-01
Recycling pathway of L1 40 2.14e-02 -2.10e-01 6.29e-02
TP53 Regulates Transcription of DNA Repair Genes 61 4.53e-03 -2.10e-01 1.75e-02
Platelet sensitization by LDL 16 1.46e-01 2.10e-01 2.74e-01
Meiotic synapsis 43 1.73e-02 -2.10e-01 5.33e-02
Disorders of transmembrane transporters 137 2.24e-05 -2.10e-01 1.50e-04
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 5.75e-04 -2.09e-01 2.90e-03
Amplification of signal from the kinetochores 91 5.75e-04 -2.09e-01 2.90e-03
Other semaphorin interactions 16 1.49e-01 2.09e-01 2.78e-01
CLEC7A/inflammasome pathway 6 3.77e-01 2.08e-01 5.36e-01
MET activates RAS signaling 10 2.55e-01 2.08e-01 4.06e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 1.11e-02 -2.07e-01 3.75e-02
RUNX3 regulates WNT signaling 8 3.10e-01 2.07e-01 4.67e-01
Activation of GABAB receptors 31 4.60e-02 2.07e-01 1.15e-01
GABA B receptor activation 31 4.60e-02 2.07e-01 1.15e-01
SARS-CoV Infections 433 1.46e-13 -2.07e-01 3.76e-12
Interleukin-23 signaling 7 3.43e-01 2.07e-01 5.02e-01
Regulation of TP53 Activity through Association with Co-factors 13 1.98e-01 2.06e-01 3.39e-01
Cell Cycle 611 3.15e-18 -2.06e-01 1.13e-16
Activation of RAC1 11 2.39e-01 2.05e-01 3.90e-01
SUMO is proteolytically processed 6 3.84e-01 -2.05e-01 5.44e-01
Repression of WNT target genes 14 1.85e-01 2.04e-01 3.23e-01
Nonhomologous End-Joining (NHEJ) 40 2.55e-02 -2.04e-01 7.27e-02
Iron uptake and transport 52 1.10e-02 -2.04e-01 3.71e-02
Biotin transport and metabolism 11 2.42e-01 -2.04e-01 3.93e-01
Trafficking of GluR2-containing AMPA receptors 11 2.43e-01 -2.04e-01 3.93e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 5.79e-02 2.03e-01 1.37e-01
Translation of Structural Proteins 9683701 29 5.83e-02 -2.03e-01 1.38e-01
Phase 2 - plateau phase 11 2.44e-01 2.03e-01 3.95e-01
Cell Cycle, Mitotic 488 1.76e-14 -2.03e-01 5.41e-13
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 2.53e-02 -2.02e-01 7.25e-02
Signaling by RAS mutants 41 2.53e-02 -2.02e-01 7.25e-02
Signaling by moderate kinase activity BRAF mutants 41 2.53e-02 -2.02e-01 7.25e-02
Signaling downstream of RAS mutants 41 2.53e-02 -2.02e-01 7.25e-02
NOTCH4 Intracellular Domain Regulates Transcription 19 1.28e-01 2.02e-01 2.49e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 3.55e-01 2.02e-01 5.14e-01
Axon guidance 459 1.28e-13 -2.02e-01 3.40e-12
Regulation of gene expression by Hypoxia-inducible Factor 8 3.23e-01 2.02e-01 4.79e-01
Fanconi Anemia Pathway 36 3.72e-02 -2.01e-01 9.85e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 1.79e-01 -2.00e-01 3.15e-01
Pyrimidine catabolism 9 2.98e-01 -2.00e-01 4.54e-01
Anchoring fibril formation 10 2.75e-01 1.99e-01 4.30e-01
Activated NTRK3 signals through RAS 7 3.61e-01 1.99e-01 5.19e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 3.63e-01 -1.98e-01 5.21e-01
Signaling by FLT3 ITD and TKD mutants 15 1.85e-01 1.98e-01 3.21e-01
Diseases of DNA repair 51 1.45e-02 -1.98e-01 4.60e-02
APC truncation mutants have impaired AXIN binding 14 2.00e-01 1.98e-01 3.40e-01
AXIN missense mutants destabilize the destruction complex 14 2.00e-01 1.98e-01 3.40e-01
Signaling by AMER1 mutants 14 2.00e-01 1.98e-01 3.40e-01
Signaling by APC mutants 14 2.00e-01 1.98e-01 3.40e-01
Signaling by AXIN mutants 14 2.00e-01 1.98e-01 3.40e-01
Truncations of AMER1 destabilize the destruction complex 14 2.00e-01 1.98e-01 3.40e-01
Asparagine N-linked glycosylation 286 8.54e-09 -1.98e-01 1.01e-07
CREB phosphorylation 7 3.65e-01 1.98e-01 5.22e-01
Signaling by ERBB2 ECD mutants 15 1.86e-01 1.97e-01 3.23e-01
Late SARS-CoV-2 Infection Events 64 6.34e-03 -1.97e-01 2.33e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 3.38e-03 -1.97e-01 1.37e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 2.81e-01 -1.97e-01 4.36e-01
Defective EXT2 causes exostoses 2 10 2.81e-01 -1.97e-01 4.36e-01
ALK mutants bind TKIs 11 2.58e-01 1.97e-01 4.10e-01
Signaling by ERBB2 in Cancer 21 1.19e-01 1.97e-01 2.36e-01
Metabolism of Angiotensinogen to Angiotensins 12 2.40e-01 1.96e-01 3.91e-01
Ethanol oxidation 8 3.38e-01 -1.96e-01 4.96e-01
Biosynthesis of maresin-like SPMs 5 4.49e-01 1.96e-01 5.98e-01
Platelet activation, signaling and aggregation 223 4.90e-07 -1.95e-01 4.38e-06
Role of ABL in ROBO-SLIT signaling 6 4.07e-01 1.95e-01 5.62e-01
mRNA Editing 8 3.39e-01 1.95e-01 4.96e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 7.91e-02 -1.95e-01 1.73e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 9.18e-02 -1.95e-01 1.93e-01
Activation of HOX genes during differentiation 70 4.86e-03 -1.95e-01 1.85e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 4.86e-03 -1.95e-01 1.85e-02
Signaling by cytosolic FGFR1 fusion mutants 18 1.53e-01 1.95e-01 2.83e-01
RHO GTPases Activate Formins 128 1.43e-04 -1.95e-01 8.24e-04
Response of Mtb to phagocytosis 22 1.14e-01 -1.95e-01 2.30e-01
Glycogen storage diseases 13 2.25e-01 -1.94e-01 3.71e-01
NCAM signaling for neurite out-growth 48 2.01e-02 1.94e-01 5.98e-02
Activation of C3 and C5 7 3.75e-01 -1.94e-01 5.34e-01
RHOV GTPase cycle 36 4.46e-02 1.93e-01 1.13e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.68e-01 1.93e-01 4.22e-01
Acetylcholine regulates insulin secretion 9 3.16e-01 1.93e-01 4.72e-01
Diseases associated with glycosaminoglycan metabolism 25 9.50e-02 -1.93e-01 1.98e-01
PLC beta mediated events 40 3.49e-02 1.93e-01 9.33e-02
Glycine degradation 7 3.77e-01 -1.93e-01 5.36e-01
G-protein mediated events 44 2.72e-02 1.92e-01 7.69e-02
N-glycan antennae elongation in the medial/trans-Golgi 21 1.28e-01 -1.92e-01 2.49e-01
Keratan sulfate degradation 9 3.20e-01 -1.91e-01 4.76e-01
Golgi-to-ER retrograde transport 123 2.59e-04 -1.91e-01 1.43e-03
Collagen chain trimerization 29 7.58e-02 1.90e-01 1.68e-01
Regulated proteolysis of p75NTR 11 2.74e-01 -1.90e-01 4.29e-01
Resolution of Sister Chromatid Cohesion 116 3.96e-04 -1.90e-01 2.11e-03
DAG and IP3 signaling 34 5.48e-02 1.90e-01 1.32e-01
Drug ADME 59 1.15e-02 -1.90e-01 3.84e-02
Mitochondrial biogenesis 91 1.70e-03 -1.90e-01 7.53e-03
E2F mediated regulation of DNA replication 22 1.23e-01 -1.90e-01 2.42e-01
Interleukin-4 and Interleukin-13 signaling 93 1.55e-03 1.90e-01 6.99e-03
Viral Messenger RNA Synthesis 44 2.94e-02 -1.90e-01 8.16e-02
Interleukin-1 signaling 99 1.11e-03 -1.90e-01 5.27e-03
Inhibition of Signaling by Overexpressed EGFR 6 4.22e-01 1.89e-01 5.74e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 4.22e-01 1.89e-01 5.74e-01
Nervous system development 478 1.27e-12 -1.89e-01 2.78e-11
SUMOylation of DNA methylation proteins 16 1.91e-01 -1.89e-01 3.30e-01
Erythrocytes take up carbon dioxide and release oxygen 11 2.78e-01 1.89e-01 4.34e-01
O2/CO2 exchange in erythrocytes 11 2.78e-01 1.89e-01 4.34e-01
CDC6 association with the ORC:origin complex 8 3.55e-01 -1.89e-01 5.14e-01
Cell-extracellular matrix interactions 16 1.91e-01 -1.89e-01 3.31e-01
TRIF-mediated programmed cell death 9 3.28e-01 1.88e-01 4.84e-01
PI-3K cascade:FGFR1 13 2.40e-01 1.88e-01 3.91e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 2.07e-01 1.88e-01 3.49e-01
Signaling by CTNNB1 phospho-site mutants 15 2.07e-01 1.88e-01 3.49e-01
Signaling by GSK3beta mutants 15 2.07e-01 1.88e-01 3.49e-01
PKA-mediated phosphorylation of CREB 17 1.81e-01 1.87e-01 3.18e-01
Signaling by activated point mutants of FGFR1 5 4.68e-01 -1.87e-01 6.15e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 3.91e-01 1.87e-01 5.49e-01
Transcriptional regulation by RUNX3 81 3.60e-03 -1.87e-01 1.43e-02
Homologous DNA Pairing and Strand Exchange 43 3.39e-02 -1.87e-01 9.11e-02
PECAM1 interactions 12 2.63e-01 1.86e-01 4.17e-01
PKA activation 15 2.12e-01 1.86e-01 3.53e-01
Signaling by RAF1 mutants 37 5.00e-02 -1.86e-01 1.22e-01
Assembly of active LPL and LIPC lipase complexes 10 3.08e-01 -1.86e-01 4.65e-01
Mitotic Prophase 96 1.62e-03 -1.86e-01 7.25e-03
Constitutive Signaling by Aberrant PI3K in Cancer 59 1.34e-02 1.86e-01 4.35e-02
Signaling by TGFBR3 39 4.44e-02 1.86e-01 1.13e-01
Nuclear events stimulated by ALK signaling in cancer 33 6.46e-02 1.86e-01 1.47e-01
CaM pathway 28 8.94e-02 1.85e-01 1.90e-01
Calmodulin induced events 28 8.94e-02 1.85e-01 1.90e-01
Other interleukin signaling 19 1.63e-01 1.85e-01 2.94e-01
Biosynthesis of maresins 7 3.99e-01 1.84e-01 5.56e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 2.50e-01 -1.84e-01 4.02e-01
PI3K Cascade 31 7.67e-02 1.84e-01 1.69e-01
Ub-specific processing proteases 153 8.78e-05 -1.84e-01 5.20e-04
Receptor-type tyrosine-protein phosphatases 12 2.72e-01 1.83e-01 4.26e-01
Regulation of pyruvate metabolism 32 7.32e-02 -1.83e-01 1.63e-01
Regulation of TP53 Activity through Phosphorylation 88 3.17e-03 -1.82e-01 1.29e-02
Programmed Cell Death 187 1.81e-05 -1.82e-01 1.25e-04
Early SARS-CoV-2 Infection Events 31 8.00e-02 -1.82e-01 1.75e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.41e-01 -1.81e-01 2.67e-01
Hyaluronan metabolism 16 2.09e-01 -1.81e-01 3.50e-01
Ca-dependent events 30 8.61e-02 1.81e-01 1.84e-01
EML4 and NUDC in mitotic spindle formation 107 1.23e-03 -1.81e-01 5.71e-03
PKA activation in glucagon signalling 14 2.44e-01 1.80e-01 3.94e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.06e-01 -1.80e-01 2.17e-01
CLEC7A (Dectin-1) signaling 86 4.09e-03 -1.79e-01 1.60e-02
XBP1(S) activates chaperone genes 44 4.05e-02 -1.78e-01 1.06e-01
Negative regulation of FGFR2 signaling 24 1.31e-01 -1.78e-01 2.54e-01
Glycogen metabolism 21 1.59e-01 -1.78e-01 2.89e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.58e-03 -1.78e-01 1.43e-02
IRS-mediated signalling 35 6.98e-02 1.77e-01 1.57e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 4.93e-01 1.77e-01 6.37e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.26e-01 -1.77e-01 2.47e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.26e-01 -1.77e-01 2.47e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.26e-01 -1.77e-01 2.47e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.26e-01 -1.77e-01 2.47e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 4.54e-01 1.77e-01 6.01e-01
ERBB2 Activates PTK6 Signaling 8 3.88e-01 1.76e-01 5.47e-01
FLT3 signaling in disease 27 1.13e-01 1.76e-01 2.28e-01
Metalloprotease DUBs 20 1.72e-01 -1.76e-01 3.06e-01
WNT ligand biogenesis and trafficking 19 1.84e-01 1.76e-01 3.21e-01
Gastrulation 76 7.99e-03 -1.76e-01 2.85e-02
Leishmania infection 211 1.15e-05 -1.75e-01 8.39e-05
Parasitic Infection Pathways 211 1.15e-05 -1.75e-01 8.39e-05
RHO GTPases Activate WASPs and WAVEs 35 7.29e-02 -1.75e-01 1.62e-01
Sodium-coupled phosphate cotransporters 5 4.98e-01 1.75e-01 6.41e-01
Digestion and absorption 7 4.24e-01 -1.75e-01 5.76e-01
Plasma lipoprotein clearance 33 8.25e-02 -1.75e-01 1.79e-01
Gene Silencing by RNA 87 5.04e-03 -1.74e-01 1.91e-02
Estrogen biosynthesis 5 5.02e-01 1.74e-01 6.46e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 5.54e-02 -1.73e-01 1.33e-01
Diseases of DNA Double-Strand Break Repair 41 5.54e-02 -1.73e-01 1.33e-01
COPI-mediated anterograde transport 92 4.33e-03 -1.72e-01 1.68e-02
Cytosolic sulfonation of small molecules 18 2.08e-01 -1.71e-01 3.49e-01
Hedgehog ‘off’ state 91 4.72e-03 -1.71e-01 1.81e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 1.97e-02 -1.71e-01 5.92e-02
Sperm Motility And Taxes 6 4.68e-01 -1.71e-01 6.15e-01
Uptake and function of diphtheria toxin 6 4.69e-01 -1.71e-01 6.15e-01
Ion transport by P-type ATPases 43 5.26e-02 1.71e-01 1.27e-01
RHO GTPase Effectors 258 2.37e-06 -1.71e-01 1.92e-05
Activation of the phototransduction cascade 8 4.05e-01 1.70e-01 5.62e-01
Transcriptional Regulation by E2F6 34 8.61e-02 -1.70e-01 1.84e-01
Metabolic disorders of biological oxidation enzymes 26 1.36e-01 -1.69e-01 2.59e-01
Signaling by Leptin 10 3.56e-01 1.69e-01 5.14e-01
ER Quality Control Compartment (ERQC) 21 1.81e-01 -1.69e-01 3.18e-01
ERKs are inactivated 13 2.94e-01 -1.68e-01 4.50e-01
Signaling by PDGFRA extracellular domain mutants 12 3.13e-01 1.68e-01 4.70e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.13e-01 1.68e-01 4.70e-01
Acyl chain remodeling of CL 5 5.18e-01 1.67e-01 6.57e-01
NGF-stimulated transcription 32 1.02e-01 1.67e-01 2.10e-01
Potential therapeutics for SARS 149 4.30e-04 -1.67e-01 2.27e-03
Serotonin Neurotransmitter Release Cycle 15 2.63e-01 1.67e-01 4.16e-01
Processing of Intronless Pre-mRNAs 20 1.96e-01 -1.67e-01 3.37e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 2.08e-01 1.67e-01 3.49e-01
P2Y receptors 10 3.61e-01 1.67e-01 5.19e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.34e-01 -1.67e-01 2.57e-01
Signaling by FGFR2 61 2.44e-02 -1.67e-01 7.08e-02
HATs acetylate histones 92 5.84e-03 -1.66e-01 2.17e-02
Activation of BH3-only proteins 30 1.15e-01 -1.66e-01 2.32e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 6.96e-02 -1.66e-01 1.57e-01
O-linked glycosylation 85 8.40e-03 1.65e-01 2.96e-02
Cell junction organization 82 9.63e-03 1.65e-01 3.34e-02
Reversible hydration of carbon dioxide 8 4.18e-01 1.65e-01 5.72e-01
Histidine catabolism 7 4.50e-01 1.65e-01 5.99e-01
Establishment of Sister Chromatid Cohesion 11 3.44e-01 1.65e-01 5.02e-01
VxPx cargo-targeting to cilium 19 2.13e-01 1.65e-01 3.56e-01
Signaling by ERBB2 TMD/JMD mutants 17 2.39e-01 1.65e-01 3.91e-01
PTEN Regulation 127 1.37e-03 -1.64e-01 6.23e-03
Impaired BRCA2 binding to PALB2 24 1.63e-01 -1.64e-01 2.94e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 8.80e-02 -1.64e-01 1.88e-01
Synthesis of PC 23 1.73e-01 -1.64e-01 3.07e-01
Netrin mediated repulsion signals 5 5.25e-01 1.64e-01 6.61e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 3.95e-01 -1.64e-01 5.53e-01
RHOBTB2 GTPase cycle 23 1.74e-01 -1.64e-01 3.08e-01
RHOT1 GTPase cycle 5 5.26e-01 -1.64e-01 6.61e-01
Toxicity of botulinum toxin type D (botD) 5 5.26e-01 1.64e-01 6.61e-01
Toxicity of botulinum toxin type F (botF) 5 5.26e-01 1.64e-01 6.61e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 4.89e-01 1.63e-01 6.34e-01
Synthesis of substrates in N-glycan biosythesis 59 3.05e-02 -1.63e-01 8.41e-02
Glycerophospholipid catabolism 6 4.90e-01 1.63e-01 6.34e-01
Na+/Cl- dependent neurotransmitter transporters 8 4.26e-01 1.63e-01 5.79e-01
Suppression of apoptosis 7 4.56e-01 -1.63e-01 6.03e-01
Potassium Channels 64 2.47e-02 1.62e-01 7.15e-02
Reproduction 85 9.81e-03 -1.62e-01 3.38e-02
Synthesis, secretion, and deacylation of Ghrelin 11 3.52e-01 -1.62e-01 5.11e-01
Erythropoietin activates RAS 13 3.12e-01 1.62e-01 4.69e-01
IRE1alpha activates chaperones 46 5.76e-02 -1.62e-01 1.37e-01
Fatty acid metabolism 155 5.24e-04 -1.61e-01 2.70e-03
Transport and synthesis of PAPS 6 4.94e-01 -1.61e-01 6.37e-01
SUMOylation of RNA binding proteins 47 5.61e-02 -1.61e-01 1.34e-01
HDACs deacetylate histones 45 6.17e-02 -1.61e-01 1.43e-01
Regulation of HSF1-mediated heat shock response 79 1.34e-02 -1.61e-01 4.35e-02
Disease 1633 2.38e-27 -1.61e-01 1.15e-25
Caspase activation via extrinsic apoptotic signalling pathway 25 1.67e-01 1.60e-01 2.99e-01
Defensins 8 4.35e-01 -1.60e-01 5.85e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.59e-01 -1.59e-01 2.90e-01
Regulation of KIT signaling 15 2.86e-01 1.59e-01 4.41e-01
Phenylalanine metabolism 5 5.39e-01 -1.59e-01 6.71e-01
Vitamin D (calciferol) metabolism 11 3.63e-01 -1.59e-01 5.20e-01
Downregulation of TGF-beta receptor signaling 26 1.62e-01 -1.58e-01 2.93e-01
Collagen degradation 44 7.00e-02 1.58e-01 1.57e-01
G0 and Early G1 27 1.58e-01 -1.57e-01 2.87e-01
IRAK2 mediated activation of TAK1 complex 10 3.90e-01 -1.57e-01 5.48e-01
Triglyceride metabolism 26 1.66e-01 1.57e-01 2.98e-01
The phototransduction cascade 26 1.68e-01 -1.56e-01 3.00e-01
Fibronectin matrix formation 6 5.09e-01 -1.56e-01 6.51e-01
Tryptophan catabolism 12 3.50e-01 -1.56e-01 5.09e-01
Cardiac conduction 89 1.11e-02 1.56e-01 3.74e-02
Cargo recognition for clathrin-mediated endocytosis 89 1.17e-02 -1.55e-01 3.91e-02
Ca2+ pathway 58 4.19e-02 1.54e-01 1.08e-01
RHO GTPases activate IQGAPs 25 1.81e-01 -1.54e-01 3.18e-01
Defective LFNG causes SCDO3 5 5.50e-01 1.54e-01 6.81e-01
Diseases of mitotic cell cycle 38 1.01e-01 -1.54e-01 2.08e-01
Regulation of TP53 Degradation 35 1.15e-01 -1.54e-01 2.32e-01
Dopamine Neurotransmitter Release Cycle 20 2.34e-01 1.54e-01 3.83e-01
Hemostasis 562 4.49e-10 -1.54e-01 6.42e-09
Sema4D in semaphorin signaling 22 2.12e-01 -1.54e-01 3.54e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 3.38e-01 1.53e-01 4.96e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 2.13e-01 1.53e-01 3.55e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.12e-01 -1.53e-01 2.27e-01
Sphingolipid metabolism 91 1.17e-02 -1.53e-01 3.90e-02
AMPK inhibits chREBP transcriptional activation activity 6 5.17e-01 -1.53e-01 6.57e-01
PKMTs methylate histone lysines 44 8.03e-02 1.52e-01 1.76e-01
Recruitment of NuMA to mitotic centrosomes 88 1.43e-02 -1.51e-01 4.56e-02
Vesicle-mediated transport 669 2.84e-11 -1.51e-01 4.95e-10
SHC1 events in EGFR signaling 12 3.69e-01 1.50e-01 5.28e-01
Integrin signaling 22 2.25e-01 -1.49e-01 3.71e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.32e-01 -1.49e-01 2.54e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 2.07e-01 1.49e-01 3.49e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 2.07e-01 1.49e-01 3.49e-01
ISG15 antiviral mechanism 72 2.93e-02 -1.49e-01 8.16e-02
G beta:gamma signalling through BTK 15 3.21e-01 -1.48e-01 4.77e-01
Interferon alpha/beta signaling 64 4.07e-02 -1.48e-01 1.06e-01
Cell-Cell communication 114 6.39e-03 1.48e-01 2.35e-02
Biological oxidations 146 2.05e-03 -1.48e-01 8.85e-03
Circadian Clock 67 3.65e-02 1.48e-01 9.69e-02
Resolution of D-Loop Structures 35 1.31e-01 -1.48e-01 2.54e-01
Free fatty acids regulate insulin secretion 10 4.19e-01 1.48e-01 5.72e-01
Thromboxane signalling through TP receptor 20 2.53e-01 -1.48e-01 4.05e-01
RHO GTPases activate CIT 18 2.79e-01 -1.48e-01 4.34e-01
Synthesis of PE 12 3.76e-01 -1.47e-01 5.35e-01
Crosslinking of collagen fibrils 15 3.24e-01 1.47e-01 4.79e-01
Cyclin D associated events in G1 47 8.12e-02 -1.47e-01 1.77e-01
G1 Phase 47 8.12e-02 -1.47e-01 1.77e-01
Glutamate Neurotransmitter Release Cycle 20 2.56e-01 1.47e-01 4.07e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 4.01e-01 1.46e-01 5.59e-01
RNA polymerase II transcribes snRNA genes 71 3.33e-02 -1.46e-01 9.01e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 5.72e-01 -1.46e-01 7.00e-01
Regulation of TP53 Expression and Degradation 36 1.31e-01 -1.46e-01 2.54e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 5.05e-01 -1.45e-01 6.48e-01
Antiviral mechanism by IFN-stimulated genes 140 2.99e-03 -1.45e-01 1.23e-02
DAP12 interactions 39 1.18e-01 1.45e-01 2.35e-01
Formation of annular gap junctions 10 4.29e-01 -1.45e-01 5.80e-01
Mitotic Prometaphase 193 5.41e-04 -1.44e-01 2.76e-03
Transport to the Golgi and subsequent modification 171 1.15e-03 -1.44e-01 5.42e-03
Depolymerization of the Nuclear Lamina 15 3.37e-01 -1.43e-01 4.95e-01
GRB2 events in EGFR signaling 11 4.13e-01 1.43e-01 5.66e-01
NRAGE signals death through JNK 52 7.52e-02 1.43e-01 1.67e-01
Beta-catenin independent WNT signaling 126 5.73e-03 -1.43e-01 2.14e-02
Antigen processing: Ubiquitination & Proteasome degradation 275 4.90e-05 -1.42e-01 3.10e-04
Uptake of dietary cobalamins into enterocytes 6 5.47e-01 1.42e-01 6.78e-01
TGFBR3 regulates TGF-beta signaling 8 4.87e-01 1.42e-01 6.32e-01
ADP signalling through P2Y purinoceptor 12 18 2.98e-01 -1.42e-01 4.54e-01
Plasma lipoprotein remodeling 18 2.98e-01 -1.42e-01 4.54e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 7.37e-04 -1.42e-01 3.60e-03
Signaling by PDGFR in disease 19 2.85e-01 1.42e-01 4.41e-01
Defects in vitamin and cofactor metabolism 21 2.63e-01 -1.41e-01 4.16e-01
Metabolism of vitamins and cofactors 166 1.70e-03 -1.41e-01 7.53e-03
Signaling by BRAF and RAF1 fusions 60 5.86e-02 -1.41e-01 1.38e-01
RAC1 GTPase cycle 173 1.38e-03 1.41e-01 6.27e-03
Post-translational modification: synthesis of GPI-anchored proteins 59 6.15e-02 -1.41e-01 1.42e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.43e-01 -1.41e-01 3.93e-01
TCR signaling 110 1.08e-02 -1.41e-01 3.67e-02
Assembly and cell surface presentation of NMDA receptors 34 1.56e-01 1.41e-01 2.85e-01
Signaling by NODAL 15 3.48e-01 -1.40e-01 5.06e-01
Cellular response to heat stress 94 1.95e-02 -1.39e-01 5.87e-02
Deadenylation of mRNA 22 2.58e-01 -1.39e-01 4.10e-01
Cytosolic sensors of pathogen-associated DNA 63 5.78e-02 -1.38e-01 1.37e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.18e-01 -1.38e-01 2.35e-01
Regulation of insulin secretion 63 5.98e-02 1.37e-01 1.39e-01
AKT phosphorylates targets in the nucleus 9 4.77e-01 1.37e-01 6.23e-01
Neurotoxicity of clostridium toxins 9 4.77e-01 1.37e-01 6.23e-01
EGFR Transactivation by Gastrin 7 5.31e-01 1.37e-01 6.64e-01
GRB2 events in ERBB2 signaling 11 4.32e-01 1.37e-01 5.83e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 4.32e-01 -1.37e-01 5.83e-01
MTOR signalling 39 1.40e-01 -1.36e-01 2.67e-01
Signaling by FGFR1 in disease 32 1.86e-01 1.35e-01 3.24e-01
PKR-mediated signaling 67 5.64e-02 -1.35e-01 1.35e-01
Activation of AMPK downstream of NMDARs 20 2.97e-01 -1.35e-01 4.54e-01
Glycosphingolipid transport 7 5.37e-01 -1.35e-01 6.71e-01
HDL remodeling 6 5.70e-01 -1.34e-01 6.98e-01
Activation of gene expression by SREBF (SREBP) 42 1.35e-01 1.33e-01 2.59e-01
Activated NTRK2 signals through FRS2 and FRS3 8 5.14e-01 1.33e-01 6.55e-01
Transcriptional Regulation by TP53 346 2.14e-05 -1.33e-01 1.44e-04
SUMOylation of DNA replication proteins 46 1.20e-01 -1.33e-01 2.38e-01
Signaling by NOTCH 175 2.48e-03 -1.33e-01 1.04e-02
Mucopolysaccharidoses 11 4.48e-01 -1.32e-01 5.98e-01
Defective B4GALT7 causes EDS, progeroid type 11 4.51e-01 -1.31e-01 5.99e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 6.13e-01 1.31e-01 7.33e-01
O-linked glycosylation of mucins 47 1.23e-01 1.30e-01 2.43e-01
STAT5 Activation 7 5.52e-01 1.30e-01 6.82e-01
Laminin interactions 26 2.52e-01 1.30e-01 4.03e-01
Class I MHC mediated antigen processing & presentation 344 3.52e-05 -1.30e-01 2.30e-04
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 5.52e-01 1.30e-01 6.82e-01
CD28 dependent Vav1 pathway 12 4.37e-01 1.30e-01 5.87e-01
Interactions of Rev with host cellular proteins 37 1.74e-01 -1.29e-01 3.08e-01
GPCR ligand binding 241 5.54e-04 1.29e-01 2.81e-03
ER to Golgi Anterograde Transport 145 7.44e-03 -1.29e-01 2.68e-02
Synthesis of IP3 and IP4 in the cytosol 22 2.98e-01 1.28e-01 4.54e-01
Striated Muscle Contraction 27 2.49e-01 1.28e-01 4.00e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.96e-01 -1.28e-01 3.37e-01
Phospholipase C-mediated cascade; FGFR2 8 5.31e-01 1.28e-01 6.64e-01
Transcriptional regulation of granulopoiesis 44 1.42e-01 -1.28e-01 2.68e-01
Sema4D induced cell migration and growth-cone collapse 19 3.35e-01 -1.28e-01 4.92e-01
AURKA Activation by TPX2 72 6.12e-02 -1.28e-01 1.42e-01
TRAF6 mediated NF-kB activation 23 2.90e-01 1.27e-01 4.46e-01
Plasma lipoprotein assembly 10 4.86e-01 1.27e-01 6.32e-01
Sphingolipid catabolism 11 4.67e-01 -1.27e-01 6.15e-01
CTLA4 inhibitory signaling 21 3.16e-01 1.27e-01 4.71e-01
Neuronal System 276 3.00e-04 1.26e-01 1.63e-03
MET activates RAP1 and RAC1 10 4.91e-01 1.26e-01 6.35e-01
Rev-mediated nuclear export of HIV RNA 35 1.98e-01 -1.26e-01 3.39e-01
Mitochondrial Uncoupling 6 5.94e-01 -1.26e-01 7.17e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.29e-02 -1.26e-01 1.10e-01
Tight junction interactions 17 3.70e-01 -1.25e-01 5.29e-01
Molybdenum cofactor biosynthesis 6 5.95e-01 -1.25e-01 7.17e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 5.39e-01 1.25e-01 6.71e-01
Oxidative Stress Induced Senescence 77 5.82e-02 -1.25e-01 1.37e-01
Eicosanoids 6 5.97e-01 1.25e-01 7.19e-01
SUMOylation of ubiquitinylation proteins 39 1.79e-01 -1.24e-01 3.15e-01
Apoptotic execution phase 46 1.46e-01 -1.24e-01 2.73e-01
Regulation of NF-kappa B signaling 18 3.65e-01 -1.23e-01 5.22e-01
SUMOylation of transcription factors 16 3.93e-01 -1.23e-01 5.52e-01
Regulation of TLR by endogenous ligand 15 4.11e-01 1.23e-01 5.64e-01
G-protein activation 19 3.56e-01 -1.22e-01 5.14e-01
Signal regulatory protein family interactions 13 4.46e-01 -1.22e-01 5.96e-01
Neurotransmitter release cycle 38 1.93e-01 1.22e-01 3.33e-01
CS/DS degradation 9 5.27e-01 -1.22e-01 6.61e-01
Clathrin-mediated endocytosis 128 1.72e-02 -1.22e-01 5.32e-02
Interleukin-12 signaling 44 1.62e-01 -1.22e-01 2.93e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.48e-01 -1.22e-01 5.98e-01
Diseases of metabolism 208 2.52e-03 -1.21e-01 1.06e-02
Prolactin receptor signaling 12 4.66e-01 -1.21e-01 6.14e-01
Maternal to zygotic transition (MZT) 72 7.51e-02 -1.21e-01 1.66e-01
Post-translational protein modification 1243 6.20e-13 -1.21e-01 1.44e-11
Signaling by FGFR2 in disease 33 2.28e-01 -1.21e-01 3.75e-01
Centrosome maturation 81 5.93e-02 -1.21e-01 1.39e-01
Recruitment of mitotic centrosome proteins and complexes 81 5.93e-02 -1.21e-01 1.39e-01
MET receptor recycling 9 5.29e-01 1.21e-01 6.63e-01
Regulation of IFNG signaling 14 4.34e-01 1.21e-01 5.85e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 3.75e-01 1.21e-01 5.34e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 2.05e-01 1.21e-01 3.47e-01
Regulation of FZD by ubiquitination 16 4.04e-01 1.20e-01 5.61e-01
HS-GAG biosynthesis 20 3.52e-01 -1.20e-01 5.11e-01
Degradation of the extracellular matrix 99 3.87e-02 1.20e-01 1.02e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 5.40e-02 1.20e-01 1.30e-01
Interleukin-12 family signaling 53 1.31e-01 -1.20e-01 2.54e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 4.22e-01 -1.20e-01 5.75e-01
Negative regulation of the PI3K/AKT network 93 4.67e-02 1.19e-01 1.16e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 5.85e-01 1.19e-01 7.11e-01
Loss of Nlp from mitotic centrosomes 69 8.67e-02 -1.19e-01 1.85e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 8.67e-02 -1.19e-01 1.85e-01
Downregulation of ERBB2 signaling 24 3.12e-01 -1.19e-01 4.69e-01
Regulation of TP53 Activity through Methylation 19 3.69e-01 -1.19e-01 5.27e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.83e-01 -1.19e-01 3.19e-01
Signaling by GPCR 442 1.91e-05 1.19e-01 1.30e-04
Assembly of collagen fibrils and other multimeric structures 44 1.73e-01 1.19e-01 3.08e-01
Adipogenesis 96 4.48e-02 1.19e-01 1.13e-01
Signal amplification 28 2.79e-01 -1.18e-01 4.34e-01
Cardiogenesis 16 4.13e-01 1.18e-01 5.66e-01
RUNX1 regulates expression of components of tight junctions 5 6.48e-01 1.18e-01 7.54e-01
G alpha (q) signalling events 139 1.67e-02 1.18e-01 5.19e-02
Regulation of signaling by NODAL 6 6.19e-01 1.17e-01 7.37e-01
RSK activation 7 5.94e-01 -1.16e-01 7.17e-01
Transcriptional regulation of white adipocyte differentiation 77 7.80e-02 1.16e-01 1.72e-01
Defective B3GAT3 causes JDSSDHD 11 5.05e-01 -1.16e-01 6.48e-01
Amino acid transport across the plasma membrane 26 3.07e-01 -1.16e-01 4.64e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 4.90e-01 -1.15e-01 6.34e-01
Cytochrome P450 - arranged by substrate type 38 2.21e-01 1.15e-01 3.66e-01
Signaling by PDGF 50 1.63e-01 1.14e-01 2.94e-01
Acetylcholine Neurotransmitter Release Cycle 11 5.13e-01 1.14e-01 6.55e-01
Metabolism of amine-derived hormones 10 5.33e-01 1.14e-01 6.66e-01
Endogenous sterols 18 4.05e-01 1.13e-01 5.62e-01
VEGFR2 mediated cell proliferation 18 4.05e-01 -1.13e-01 5.62e-01
Cellular Senescence 143 1.95e-02 -1.13e-01 5.87e-02
Transport of the SLBP Dependant Mature mRNA 36 2.40e-01 -1.13e-01 3.91e-01
Frs2-mediated activation 11 5.17e-01 -1.13e-01 6.57e-01
Surfactant metabolism 21 3.71e-01 -1.13e-01 5.30e-01
Keratan sulfate biosynthesis 20 3.84e-01 1.12e-01 5.44e-01
Signaling by Hedgehog 120 3.36e-02 -1.12e-01 9.08e-02
Transcriptional regulation by RUNX1 170 1.17e-02 -1.12e-01 3.90e-02
TGF-beta receptor signaling activates SMADs 45 1.96e-01 -1.12e-01 3.37e-01
Regulation of localization of FOXO transcription factors 11 5.22e-01 -1.11e-01 6.61e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 3.17e-01 -1.11e-01 4.72e-01
Deactivation of the beta-catenin transactivating complex 36 2.48e-01 1.11e-01 3.99e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 3.91e-01 1.11e-01 5.49e-01
RND2 GTPase cycle 37 2.43e-01 1.11e-01 3.94e-01
Signaling by NTRK2 (TRKB) 20 3.91e-01 1.11e-01 5.49e-01
FGFR1c ligand binding and activation 8 5.88e-01 -1.11e-01 7.13e-01
Cell recruitment (pro-inflammatory response) 25 3.39e-01 -1.11e-01 4.96e-01
Purinergic signaling in leishmaniasis infection 25 3.39e-01 -1.11e-01 4.96e-01
RHO GTPases Activate NADPH Oxidases 21 3.81e-01 1.10e-01 5.41e-01
Downregulation of ERBB2:ERBB3 signaling 12 5.08e-01 -1.10e-01 6.51e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 4.32e-01 1.10e-01 5.83e-01
SUMOylation of chromatin organization proteins 57 1.51e-01 -1.10e-01 2.81e-01
Effects of PIP2 hydrolysis 24 3.52e-01 1.10e-01 5.11e-01
Activated NTRK2 signals through RAS 6 6.42e-01 1.10e-01 7.49e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 9.99e-03 -1.09e-01 3.43e-02
Activation of G protein gated Potassium channels 20 3.98e-01 1.09e-01 5.56e-01
G protein gated Potassium channels 20 3.98e-01 1.09e-01 5.56e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 3.98e-01 1.09e-01 5.56e-01
Biosynthesis of E-series 18(S)-resolvins 5 6.73e-01 1.09e-01 7.72e-01
RET signaling 32 2.86e-01 1.09e-01 4.42e-01
IRF3-mediated induction of type I IFN 12 5.14e-01 -1.09e-01 6.55e-01
RAC2 GTPase cycle 86 8.24e-02 1.08e-01 1.79e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 3.14e-01 -1.08e-01 4.71e-01
Antimicrobial peptides 34 2.79e-01 -1.07e-01 4.34e-01
Attachment of GPI anchor to uPAR 7 6.23e-01 -1.07e-01 7.39e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 1.66e-01 -1.07e-01 2.98e-01
RUNX2 regulates genes involved in cell migration 6 6.50e-01 1.07e-01 7.55e-01
Interleukin-1 family signaling 127 3.78e-02 -1.07e-01 9.96e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 1.93e-01 1.06e-01 3.33e-01
Membrane Trafficking 577 1.29e-05 -1.06e-01 9.38e-05
TNFR1-induced NF-kappa-B signaling pathway 32 2.99e-01 1.06e-01 4.56e-01
Interactions of Vpr with host cellular proteins 37 2.67e-01 -1.05e-01 4.22e-01
Sensory processing of sound by inner hair cells of the cochlea 54 1.84e-01 1.04e-01 3.21e-01
Transmission across Chemical Synapses 188 1.36e-02 1.04e-01 4.39e-02
CD28 dependent PI3K/Akt signaling 22 4.00e-01 1.04e-01 5.58e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 2.70e-01 -1.03e-01 4.25e-01
Synthesis of PIPs at the late endosome membrane 11 5.53e-01 1.03e-01 6.82e-01
Phospholipase C-mediated cascade; FGFR4 6 6.62e-01 1.03e-01 7.64e-01
STAT5 activation downstream of FLT3 ITD mutants 9 5.92e-01 1.03e-01 7.17e-01
Organic cation transport 8 6.14e-01 1.03e-01 7.33e-01
Organic cation/anion/zwitterion transport 8 6.14e-01 1.03e-01 7.33e-01
GPCR downstream signalling 398 4.33e-04 1.03e-01 2.28e-03
Nuclear Events (kinase and transcription factor activation) 54 1.92e-01 1.03e-01 3.33e-01
Miscellaneous transport and binding events 20 4.28e-01 -1.02e-01 5.80e-01
Carnitine shuttle 12 5.40e-01 1.02e-01 6.72e-01
FGFR2b ligand binding and activation 6 6.66e-01 1.02e-01 7.65e-01
Dermatan sulfate biosynthesis 6 6.66e-01 -1.02e-01 7.65e-01
Acyl chain remodelling of PC 19 4.43e-01 1.02e-01 5.93e-01
Regulation of TP53 Activity through Acetylation 29 3.44e-01 1.02e-01 5.02e-01
HS-GAG degradation 19 4.46e-01 -1.01e-01 5.96e-01
activated TAK1 mediates p38 MAPK activation 23 4.02e-01 -1.01e-01 5.59e-01
Interferon Signaling 240 7.13e-03 -1.01e-01 2.59e-02
cGMP effects 12 5.46e-01 -1.01e-01 6.77e-01
PI3K/AKT Signaling in Cancer 85 1.09e-01 1.01e-01 2.22e-01
Apoptotic cleavage of cell adhesion proteins 8 6.23e-01 -1.00e-01 7.39e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 4.05e-01 -1.00e-01 5.62e-01
Metabolism of water-soluble vitamins and cofactors 115 6.36e-02 -1.00e-01 1.46e-01
EPH-Ephrin signaling 81 1.20e-01 -9.99e-02 2.38e-01
Organelle biogenesis and maintenance 277 4.24e-03 -9.98e-02 1.65e-02
A tetrasaccharide linker sequence is required for GAG synthesis 17 4.76e-01 -9.98e-02 6.23e-01
Sensory perception of taste 22 4.18e-01 9.98e-02 5.72e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.86e-01 9.95e-02 7.12e-01
PI5P Regulates TP53 Acetylation 8 6.26e-01 9.95e-02 7.41e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 4.17e-02 9.93e-02 1.08e-01
PI3K/AKT activation 8 6.27e-01 9.91e-02 7.41e-01
G alpha (s) signalling events 97 9.27e-02 9.88e-02 1.94e-01
Regulation of TP53 Activity 153 3.52e-02 -9.87e-02 9.39e-02
OAS antiviral response 8 6.30e-01 -9.84e-02 7.42e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 5.24e-01 9.84e-02 6.61e-01
HDR through Single Strand Annealing (SSA) 37 3.02e-01 -9.80e-02 4.59e-01
Inwardly rectifying K+ channels 24 4.07e-01 9.78e-02 5.62e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 5.75e-01 -9.77e-02 7.01e-01
Organic anion transporters 7 6.55e-01 -9.75e-02 7.60e-01
Respiratory Syncytial Virus Infection Pathway 99 9.41e-02 -9.74e-02 1.97e-01
Beta-catenin phosphorylation cascade 17 4.88e-01 9.71e-02 6.33e-01
MAPK1 (ERK2) activation 9 6.14e-01 9.71e-02 7.33e-01
SUMOylation of SUMOylation proteins 35 3.21e-01 -9.69e-02 4.77e-01
LDL clearance 18 4.78e-01 -9.67e-02 6.24e-01
GPVI-mediated activation cascade 33 3.37e-01 9.65e-02 4.95e-01
Glycosphingolipid metabolism 46 2.58e-01 -9.64e-02 4.10e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.17e-01 9.63e-02 3.60e-01
Butyrophilin (BTN) family interactions 9 6.17e-01 9.62e-02 7.35e-01
Sensory Perception 197 1.99e-02 9.62e-02 5.96e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 7.10e-01 -9.59e-02 8.06e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 7.10e-01 -9.59e-02 8.06e-01
Activation of Matrix Metalloproteinases 22 4.36e-01 9.59e-02 5.87e-01
RUNX3 regulates CDKN1A transcription 7 6.62e-01 9.55e-02 7.64e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 3.83e-01 -9.53e-02 5.42e-01
Metabolism of carbohydrates 241 1.10e-02 -9.51e-02 3.71e-02
Ovarian tumor domain proteases 37 3.17e-01 9.50e-02 4.72e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 5.38e-01 -9.50e-02 6.71e-01
Impaired BRCA2 binding to RAD51 35 3.32e-01 -9.48e-02 4.89e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 5.71e-01 -9.45e-02 6.99e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 4.43e-01 9.45e-02 5.93e-01
DAP12 signaling 28 3.87e-01 9.44e-02 5.47e-01
Norepinephrine Neurotransmitter Release Cycle 14 5.42e-01 9.41e-02 6.74e-01
Signaling by SCF-KIT 40 3.05e-01 9.37e-02 4.62e-01
Formation of definitive endoderm 9 6.27e-01 9.35e-02 7.41e-01
Nuclear import of Rev protein 34 3.45e-01 -9.35e-02 5.03e-01
Transferrin endocytosis and recycling 26 4.10e-01 -9.33e-02 5.64e-01
Maturation of protein 3a 9683673 9 6.28e-01 9.32e-02 7.41e-01
Maturation of protein 3a 9694719 9 6.28e-01 9.32e-02 7.41e-01
Class A/1 (Rhodopsin-like receptors) 175 3.44e-02 9.27e-02 9.22e-02
EPHB-mediated forward signaling 40 3.10e-01 -9.27e-02 4.67e-01
Synthesis of very long-chain fatty acyl-CoAs 22 4.52e-01 -9.25e-02 6.00e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 4.06e-01 -9.24e-02 5.62e-01
Adaptive Immune System 768 1.37e-05 -9.22e-02 9.82e-05
Killing mechanisms 9 6.33e-01 -9.18e-02 7.43e-01
WNT5:FZD7-mediated leishmania damping 9 6.33e-01 -9.18e-02 7.43e-01
Heme biosynthesis 13 5.69e-01 -9.12e-02 6.98e-01
Listeria monocytogenes entry into host cells 17 5.17e-01 -9.07e-02 6.57e-01
Respiratory syncytial virus (RSV) attachment and entry 18 5.06e-01 9.05e-02 6.49e-01
Gap junction assembly 17 5.20e-01 -9.01e-02 6.59e-01
CDC42 GTPase cycle 141 6.50e-02 9.00e-02 1.48e-01
FRS-mediated FGFR2 signaling 15 5.48e-01 8.96e-02 6.78e-01
Transport of the SLBP independent Mature mRNA 35 3.59e-01 -8.96e-02 5.17e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 5.23e-01 8.94e-02 6.61e-01
Insulin receptor signalling cascade 40 3.28e-01 8.93e-02 4.85e-01
COPII-mediated vesicle transport 67 2.07e-01 -8.91e-02 3.49e-01
ROS and RNS production in phagocytes 30 4.00e-01 -8.87e-02 5.58e-01
Gain-of-function MRAS complexes activate RAF signaling 8 6.65e-01 8.85e-02 7.65e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 6.65e-01 8.85e-02 7.65e-01
Signaling by MRAS-complex mutants 8 6.65e-01 8.85e-02 7.65e-01
Negative regulation of MET activity 18 5.16e-01 8.85e-02 6.56e-01
Integration of energy metabolism 88 1.52e-01 8.84e-02 2.82e-01
Growth hormone receptor signaling 21 4.83e-01 8.84e-02 6.29e-01
Acyl chain remodelling of PE 20 4.94e-01 -8.83e-02 6.37e-01
Downstream signal transduction 27 4.28e-01 8.82e-02 5.80e-01
Transcriptional activation of mitochondrial biogenesis 52 2.71e-01 8.82e-02 4.26e-01
RND3 GTPase cycle 36 3.60e-01 8.81e-02 5.19e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 4.56e-01 8.80e-02 6.03e-01
Aspartate and asparagine metabolism 9 6.49e-01 8.77e-02 7.54e-01
Signaling by ALK fusions and activated point mutants 89 1.54e-01 8.74e-02 2.84e-01
Signaling by ALK in cancer 89 1.54e-01 8.74e-02 2.84e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 5.11e-01 -8.72e-02 6.53e-01
Nephron development 5 7.36e-01 8.71e-02 8.23e-01
Sensory processing of sound 58 2.52e-01 8.69e-02 4.03e-01
RAB geranylgeranylation 61 2.40e-01 -8.69e-02 3.91e-01
CD28 co-stimulation 33 3.88e-01 8.68e-02 5.47e-01
MET activates PTK2 signaling 23 4.71e-01 -8.67e-02 6.18e-01
Notch-HLH transcription pathway 28 4.27e-01 8.67e-02 5.80e-01
DARPP-32 events 22 4.83e-01 -8.64e-02 6.29e-01
FGFR1 mutant receptor activation 25 4.55e-01 8.62e-02 6.03e-01
Inositol phosphate metabolism 42 3.34e-01 8.62e-02 4.91e-01
Sema3A PAK dependent Axon repulsion 15 5.64e-01 8.61e-02 6.92e-01
Oncogenic MAPK signaling 76 1.98e-01 -8.54e-02 3.39e-01
Diseases associated with surfactant metabolism 6 7.17e-01 -8.53e-02 8.10e-01
Heparan sulfate/heparin (HS-GAG) metabolism 40 3.51e-01 -8.53e-02 5.10e-01
Innate Immune System 971 8.40e-06 -8.44e-02 6.32e-05
Glucagon signaling in metabolic regulation 26 4.56e-01 8.44e-02 6.03e-01
RUNX2 regulates osteoblast differentiation 21 5.05e-01 8.40e-02 6.48e-01
Eicosanoid ligand-binding receptors 13 6.03e-01 -8.33e-02 7.24e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 6.33e-01 -8.32e-02 7.43e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 7.03e-01 8.31e-02 7.99e-01
Zinc transporters 12 6.18e-01 -8.31e-02 7.36e-01
SUMOylation of intracellular receptors 26 4.66e-01 8.25e-02 6.14e-01
Sensing of DNA Double Strand Breaks 6 7.27e-01 8.22e-02 8.18e-01
Nuclear Envelope Breakdown 53 3.05e-01 -8.14e-02 4.62e-01
Formation of the Editosome 6 7.31e-01 8.11e-02 8.20e-01
mRNA Editing: C to U Conversion 6 7.31e-01 8.11e-02 8.20e-01
Signaling by EGFR in Cancer 23 5.03e-01 8.07e-02 6.47e-01
Synthesis of 5-eicosatetraenoic acids 7 7.13e-01 -8.04e-02 8.07e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 2.85e-01 -7.92e-02 4.40e-01
Developmental Biology 929 4.27e-05 -7.92e-02 2.74e-04
G alpha (12/13) signalling events 68 2.61e-01 7.88e-02 4.14e-01
Neutrophil degranulation 458 3.85e-03 -7.88e-02 1.52e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 6.23e-01 -7.87e-02 7.39e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 7.39e-01 7.87e-02 8.25e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 2.21e-01 7.86e-02 3.66e-01
Defects in cobalamin (B12) metabolism 13 6.24e-01 -7.86e-02 7.39e-01
FOXO-mediated transcription of cell cycle genes 15 6.00e-01 7.82e-02 7.22e-01
Regulation of TNFR1 signaling 47 3.57e-01 7.77e-02 5.15e-01
Vitamin B2 (riboflavin) metabolism 6 7.42e-01 -7.75e-02 8.27e-01
Nicotinamide salvaging 15 6.03e-01 -7.75e-02 7.24e-01
Netrin-1 signaling 35 4.28e-01 7.74e-02 5.80e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.52e-01 -7.68e-02 6.00e-01
Kidney development 17 5.86e-01 -7.63e-02 7.12e-01
NOD1/2 Signaling Pathway 36 4.29e-01 7.62e-02 5.80e-01
C-type lectin receptors (CLRs) 118 1.53e-01 -7.62e-02 2.83e-01
SLC15A4:TASL-dependent IRF5 activation 6 7.48e-01 -7.59e-02 8.32e-01
SUMOylation of DNA damage response and repair proteins 77 2.50e-01 -7.58e-02 4.02e-01
Stimuli-sensing channels 81 2.40e-01 7.55e-02 3.91e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 4.04e-01 -7.54e-02 5.61e-01
Fatty acyl-CoA biosynthesis 35 4.40e-01 -7.54e-02 5.91e-01
Synthesis of PG 8 7.12e-01 7.53e-02 8.06e-01
Neurofascin interactions 5 7.72e-01 7.47e-02 8.50e-01
Deubiquitination 225 5.41e-02 -7.45e-02 1.30e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.52e-01 7.45e-02 8.33e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.52e-01 7.45e-02 8.33e-01
Phospholipid metabolism 183 8.35e-02 7.42e-02 1.80e-01
FGFR2c ligand binding and activation 5 7.75e-01 7.37e-02 8.51e-01
Glucose metabolism 76 2.71e-01 -7.31e-02 4.25e-01
Toll Like Receptor 4 (TLR4) Cascade 138 1.38e-01 7.30e-02 2.64e-01
Acyl chain remodelling of PS 14 6.37e-01 7.28e-02 7.45e-01
Signaling by FGFR 73 2.84e-01 -7.25e-02 4.40e-01
FRS-mediated FGFR4 signaling 13 6.52e-01 7.23e-02 7.57e-01
SHC-mediated cascade:FGFR2 13 6.52e-01 7.22e-02 7.57e-01
PD-1 signaling 28 5.09e-01 7.21e-02 6.52e-01
Phosphorylation of CD3 and TCR zeta chains 27 5.18e-01 7.19e-02 6.57e-01
RHOF GTPase cycle 39 4.38e-01 7.18e-02 5.88e-01
Uptake and function of anthrax toxins 11 6.81e-01 7.16e-02 7.80e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.95e-01 -7.15e-02 7.93e-01
Bacterial Infection Pathways 66 3.15e-01 -7.15e-02 4.71e-01
Gap junction trafficking 28 5.14e-01 -7.13e-02 6.55e-01
Biosynthesis of DHA-derived SPMs 15 6.33e-01 7.12e-02 7.43e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.96e-01 -7.03e-02 7.18e-01
G beta:gamma signalling through PLC beta 17 6.17e-01 -7.01e-02 7.35e-01
Presynaptic function of Kainate receptors 17 6.17e-01 -7.01e-02 7.35e-01
Vitamin B5 (pantothenate) metabolism 20 5.88e-01 -6.99e-02 7.13e-01
Muscle contraction 145 1.48e-01 6.96e-02 2.76e-01
Glycolysis 68 3.22e-01 -6.95e-02 4.78e-01
Costimulation by the CD28 family 74 3.05e-01 6.90e-02 4.62e-01
Loss of Function of TGFBR1 in Cancer 7 7.52e-01 -6.89e-02 8.33e-01
Small interfering RNA (siRNA) biogenesis 9 7.21e-01 6.88e-02 8.12e-01
Carboxyterminal post-translational modifications of tubulin 34 4.90e-01 -6.84e-02 6.34e-01
Aspirin ADME 16 6.36e-01 -6.84e-02 7.44e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 4.97e-01 6.84e-02 6.40e-01
Nuclear signaling by ERBB4 24 5.63e-01 -6.83e-02 6.92e-01
Ion homeostasis 42 4.44e-01 6.82e-02 5.94e-01
Signaling by Non-Receptor Tyrosine Kinases 47 4.20e-01 -6.81e-02 5.72e-01
Signaling by PTK6 47 4.20e-01 -6.81e-02 5.72e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.59e-01 -6.80e-02 7.62e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.59e-01 -6.80e-02 7.62e-01
SARS-CoV-1 activates/modulates innate immune responses 40 4.58e-01 -6.79e-02 6.04e-01
Pre-NOTCH Processing in Golgi 18 6.20e-01 6.75e-02 7.37e-01
Signaling by Hippo 18 6.20e-01 6.75e-02 7.37e-01
Creatine metabolism 6 7.75e-01 6.73e-02 8.51e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 5.63e-01 -6.69e-02 6.92e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 4.14e-01 -6.68e-02 5.67e-01
Ion channel transport 141 1.71e-01 6.68e-02 3.04e-01
Fertilization 12 6.90e-01 -6.65e-02 7.89e-01
Gamma-carboxylation of protein precursors 6 7.80e-01 6.59e-02 8.55e-01
FLT3 Signaling 38 4.83e-01 6.58e-02 6.29e-01
FGFR3 ligand binding and activation 5 8.00e-01 6.56e-02 8.67e-01
FGFR3c ligand binding and activation 5 8.00e-01 6.56e-02 8.67e-01
RIPK1-mediated regulated necrosis 31 5.29e-01 6.54e-02 6.63e-01
Regulation of necroptotic cell death 31 5.29e-01 6.54e-02 6.63e-01
CHL1 interactions 8 7.49e-01 -6.52e-02 8.33e-01
Reelin signalling pathway 5 8.01e-01 6.51e-02 8.68e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 6.25e-01 6.48e-02 7.40e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 6.35e-01 6.47e-02 7.44e-01
Hydrolysis of LPC 8 7.52e-01 -6.45e-02 8.33e-01
RHO GTPases activate KTN1 11 7.12e-01 6.43e-02 8.06e-01
Cytoprotection by HMOX1 53 4.19e-01 -6.42e-02 5.72e-01
Regulation of PTEN gene transcription 59 3.94e-01 -6.41e-02 5.53e-01
MET promotes cell motility 33 5.24e-01 -6.41e-02 6.61e-01
EGFR downregulation 27 5.64e-01 -6.41e-02 6.93e-01
Lysine catabolism 11 7.16e-01 -6.33e-02 8.09e-01
FasL/ CD95L signaling 5 8.07e-01 6.32e-02 8.71e-01
Nucleotide-like (purinergic) receptors 13 6.97e-01 6.24e-02 7.95e-01
Sialic acid metabolism 28 5.68e-01 6.24e-02 6.97e-01
Regulation of endogenous retroelements 92 3.02e-01 -6.22e-02 4.59e-01
Transport of small molecules 558 1.28e-02 -6.17e-02 4.19e-02
CRMPs in Sema3A signaling 13 7.01e-01 6.15e-02 7.97e-01
Proton-coupled monocarboxylate transport 6 7.94e-01 -6.15e-02 8.64e-01
Vpr-mediated nuclear import of PICs 34 5.42e-01 -6.04e-02 6.74e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 7.30e-01 6.01e-02 8.20e-01
Kinesins 51 4.59e-01 -5.99e-02 6.06e-01
Regulation of lipid metabolism by PPARalpha 107 2.84e-01 5.99e-02 4.40e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 4.38e-01 5.99e-02 5.88e-01
Inflammasomes 21 6.35e-01 5.98e-02 7.44e-01
Translocation of ZAP-70 to Immunological synapse 24 6.13e-01 5.96e-02 7.33e-01
TNF signaling 56 4.42e-01 5.94e-02 5.92e-01
Nitric oxide stimulates guanylate cyclase 15 6.92e-01 -5.92e-02 7.90e-01
Beta-oxidation of very long chain fatty acids 11 7.34e-01 -5.91e-02 8.22e-01
Intraflagellar transport 47 4.85e-01 -5.89e-02 6.31e-01
Signaling by VEGF 100 3.09e-01 -5.88e-02 4.67e-01
MyD88-independent TLR4 cascade 108 2.92e-01 5.87e-02 4.49e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 2.92e-01 5.87e-02 4.49e-01
Signalling to RAS 19 6.58e-01 5.86e-02 7.62e-01
Regulated Necrosis 56 4.51e-01 -5.83e-02 5.99e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 8.05e-01 5.82e-02 8.71e-01
Acyl chain remodelling of PI 10 7.51e-01 5.79e-02 8.33e-01
Synthesis of pyrophosphates in the cytosol 8 7.77e-01 -5.77e-02 8.53e-01
Phase 3 - rapid repolarisation 6 8.07e-01 5.77e-02 8.71e-01
TCF dependent signaling in response to WNT 153 2.18e-01 -5.77e-02 3.62e-01
LTC4-CYSLTR mediated IL4 production 5 8.24e-01 -5.73e-02 8.82e-01
G beta:gamma signalling through CDC42 17 6.83e-01 -5.71e-02 7.82e-01
Non-integrin membrane-ECM interactions 51 4.82e-01 -5.69e-02 6.29e-01
Generation of second messenger molecules 38 5.45e-01 5.68e-02 6.76e-01
Loss of Function of SMAD2/3 in Cancer 7 7.95e-01 5.66e-02 8.64e-01
Sensory processing of sound by outer hair cells of the cochlea 41 5.31e-01 5.66e-02 6.64e-01
Opioid Signalling 75 3.97e-01 5.66e-02 5.56e-01
Maturation of nucleoprotein 9683610 11 7.46e-01 -5.63e-02 8.31e-01
AKT phosphorylates targets in the cytosol 14 7.18e-01 -5.58e-02 8.10e-01
Lewis blood group biosynthesis 14 7.19e-01 5.55e-02 8.11e-01
TNFs bind their physiological receptors 25 6.31e-01 5.55e-02 7.43e-01
Cargo trafficking to the periciliary membrane 47 5.11e-01 -5.54e-02 6.53e-01
Acyl chain remodelling of PG 11 7.52e-01 5.51e-02 8.33e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 6.41e-01 5.50e-02 7.49e-01
Gap junction trafficking and regulation 30 6.03e-01 -5.49e-02 7.24e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 5.58e-01 -5.49e-02 6.88e-01
RHO GTPase cycle 412 5.63e-02 5.48e-02 1.35e-01
Arachidonate metabolism 45 5.25e-01 -5.48e-02 6.61e-01
Cilium Assembly 186 1.99e-01 -5.46e-02 3.40e-01
ARMS-mediated activation 6 8.17e-01 5.45e-02 8.76e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 7.25e-01 5.44e-02 8.16e-01
Anchoring of the basal body to the plasma membrane 97 3.55e-01 -5.43e-02 5.14e-01
Activation of kainate receptors upon glutamate binding 26 6.33e-01 5.41e-02 7.43e-01
Tie2 Signaling 16 7.09e-01 5.39e-02 8.05e-01
WNT mediated activation of DVL 8 7.92e-01 5.38e-02 8.64e-01
Signaling by NTRKs 117 3.16e-01 5.36e-02 4.72e-01
Death Receptor Signaling 145 2.68e-01 5.33e-02 4.22e-01
Relaxin receptors 5 8.39e-01 5.25e-02 8.92e-01
Toll-like Receptor Cascades 162 2.51e-01 5.22e-02 4.03e-01
GPER1 signaling 38 5.78e-01 -5.21e-02 7.04e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 4.07e-01 -5.21e-02 5.62e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 4.07e-01 -5.21e-02 5.62e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 4.07e-01 -5.21e-02 5.62e-01
Formation of WDR5-containing histone-modifying complexes 42 5.61e-01 5.19e-02 6.91e-01
RSV-host interactions 78 4.31e-01 -5.16e-02 5.83e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 5.94e-01 5.13e-02 7.17e-01
TP53 Regulates Transcription of Cell Death Genes 43 5.64e-01 5.09e-02 6.92e-01
Ephrin signaling 18 7.11e-01 5.05e-02 8.06e-01
Glycerophospholipid biosynthesis 105 3.74e-01 -5.02e-02 5.33e-01
NS1 Mediated Effects on Host Pathways 40 5.88e-01 -4.95e-02 7.13e-01
Toll Like Receptor 3 (TLR3) Cascade 104 3.83e-01 4.95e-02 5.42e-01
Attenuation phase 23 6.83e-01 -4.92e-02 7.82e-01
Transcriptional Regulation by VENTX 39 5.95e-01 4.92e-02 7.17e-01
RUNX2 regulates bone development 26 6.64e-01 4.92e-02 7.65e-01
Prolonged ERK activation events 13 7.60e-01 -4.89e-02 8.40e-01
SHC-mediated cascade:FGFR4 11 7.81e-01 4.84e-02 8.55e-01
Integrin cell surface interactions 68 4.92e-01 4.82e-02 6.36e-01
Immune System 1841 6.29e-04 -4.81e-02 3.11e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 7.73e-01 4.80e-02 8.51e-01
RHOB GTPase cycle 65 5.05e-01 4.78e-02 6.48e-01
Negative regulation of MAPK pathway 42 5.93e-01 -4.76e-02 7.17e-01
Blood group systems biosynthesis 18 7.28e-01 4.73e-02 8.19e-01
Gene expression (Transcription) 1413 2.91e-03 -4.73e-02 1.20e-02
Metabolism of lipids 642 4.21e-02 -4.70e-02 1.08e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 4.17e-01 4.70e-02 5.71e-01
Visual phototransduction 60 5.30e-01 -4.69e-02 6.64e-01
Signaling by CSF3 (G-CSF) 29 6.63e-01 4.67e-02 7.65e-01
Diseases of glycosylation 109 4.00e-01 -4.67e-02 5.57e-01
SHC1 events in ERBB2 signaling 17 7.40e-01 4.66e-02 8.25e-01
PPARA activates gene expression 105 4.10e-01 4.65e-02 5.64e-01
SOS-mediated signalling 7 8.32e-01 4.64e-02 8.87e-01
Export of Viral Ribonucleoproteins from Nucleus 33 6.45e-01 -4.64e-02 7.52e-01
MAP kinase activation 63 5.26e-01 -4.62e-02 6.61e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 4.09e-01 4.60e-02 5.63e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 4.09e-01 4.60e-02 5.63e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 7.29e-01 -4.60e-02 8.19e-01
Signaling by FGFR1 42 6.07e-01 4.59e-02 7.27e-01
Metabolism of fat-soluble vitamins 28 6.74e-01 -4.59e-02 7.73e-01
Signaling by NOTCH1 68 5.13e-01 4.58e-02 6.55e-01
MITF-M-dependent gene expression 83 4.71e-01 4.58e-02 6.18e-01
Nuclear Pore Complex (NPC) Disassembly 36 6.35e-01 -4.57e-02 7.44e-01
Signaling by NOTCH3 44 6.00e-01 -4.56e-02 7.22e-01
PIP3 activates AKT signaling 235 2.29e-01 -4.56e-02 3.76e-01
Alpha-protein kinase 1 signaling pathway 11 7.94e-01 -4.54e-02 8.64e-01
Chromatin modifying enzymes 215 2.52e-01 4.53e-02 4.03e-01
Chromatin organization 215 2.52e-01 4.53e-02 4.03e-01
MyD88 dependent cascade initiated on endosome 101 4.32e-01 4.52e-02 5.83e-01
Signaling by TGFB family members 139 3.62e-01 4.48e-02 5.19e-01
RAF/MAP kinase cascade 226 2.46e-01 -4.48e-02 3.97e-01
Signaling by Insulin receptor 63 5.39e-01 -4.48e-02 6.71e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 7.43e-01 -4.46e-02 8.28e-01
FRS-mediated FGFR1 signaling 15 7.65e-01 4.46e-02 8.45e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 7.75e-01 4.41e-02 8.51e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 6.58e-01 4.39e-02 7.62e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 5.75e-01 -4.37e-02 7.01e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 5.75e-01 -4.37e-02 7.01e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 5.75e-01 -4.37e-02 7.01e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 5.75e-01 -4.37e-02 7.01e-01
Signaling by NOTCH1 in Cancer 55 5.75e-01 -4.37e-02 7.01e-01
Phospholipase C-mediated cascade: FGFR1 8 8.31e-01 4.35e-02 8.87e-01
L1CAM interactions 100 4.53e-01 -4.34e-02 6.01e-01
Signaling by FGFR in disease 52 5.89e-01 -4.33e-02 7.14e-01
Aquaporin-mediated transport 38 6.45e-01 4.32e-02 7.52e-01
Signaling by NTRK1 (TRKA) 102 4.52e-01 4.31e-02 6.00e-01
Signaling by Interleukins 391 1.47e-01 4.27e-02 2.75e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 4.51e-01 4.26e-02 5.99e-01
NPAS4 regulates expression of target genes 16 7.69e-01 4.24e-02 8.47e-01
RHOJ GTPase cycle 50 6.04e-01 -4.23e-02 7.25e-01
Gap junction degradation 11 8.09e-01 -4.20e-02 8.73e-01
Attachment and Entry 9694614 14 7.86e-01 4.19e-02 8.59e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 8.49e-01 -4.17e-02 8.99e-01
Toll Like Receptor 9 (TLR9) Cascade 108 4.61e-01 4.11e-02 6.07e-01
Epigenetic regulation of gene expression 263 2.57e-01 -4.06e-02 4.10e-01
Rap1 signalling 14 7.93e-01 4.05e-02 8.64e-01
RHOG GTPase cycle 71 5.58e-01 -4.03e-02 6.87e-01
Peptide ligand-binding receptors 101 4.86e-01 4.01e-02 6.32e-01
FOXO-mediated transcription 58 5.97e-01 4.01e-02 7.19e-01
Activated point mutants of FGFR2 7 8.55e-01 3.99e-02 9.03e-01
Evasion by RSV of host interferon responses 20 7.58e-01 3.98e-02 8.38e-01
SUMOylation of immune response proteins 12 8.12e-01 3.97e-02 8.74e-01
Elevation of cytosolic Ca2+ levels 13 8.05e-01 -3.96e-02 8.71e-01
Toll Like Receptor 2 (TLR2) Cascade 109 4.76e-01 3.95e-02 6.23e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 4.76e-01 3.95e-02 6.23e-01
Retinoid metabolism and transport 25 7.33e-01 3.94e-02 8.21e-01
MAPK3 (ERK1) activation 10 8.30e-01 3.93e-02 8.87e-01
MAPK1/MAPK3 signaling 232 3.02e-01 -3.93e-02 4.59e-01
FRS-mediated FGFR3 signaling 12 8.14e-01 3.92e-02 8.75e-01
CaMK IV-mediated phosphorylation of CREB 9 8.39e-01 3.91e-02 8.92e-01
RNA Polymerase II Transcription 1206 2.24e-02 -3.90e-02 6.56e-02
Chemokine receptors bind chemokines 39 6.74e-01 3.89e-02 7.73e-01
p75 NTR receptor-mediated signalling 89 5.26e-01 -3.89e-02 6.61e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 6.06e-01 -3.89e-02 7.26e-01
RAF activation 33 7.01e-01 -3.86e-02 7.97e-01
Glycogen breakdown (glycogenolysis) 12 8.18e-01 3.83e-02 8.77e-01
Retrograde transport at the Trans-Golgi-Network 49 6.46e-01 -3.80e-02 7.52e-01
RAC3 GTPase cycle 88 5.38e-01 3.79e-02 6.71e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 7.95e-01 3.76e-02 8.64e-01
SUMOylation of transcription cofactors 44 6.66e-01 -3.76e-02 7.65e-01
Peptide hormone metabolism 54 6.33e-01 3.75e-02 7.43e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 7.15e-01 -3.73e-02 8.08e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 7.15e-01 -3.73e-02 8.08e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 8.48e-01 -3.70e-02 8.98e-01
Signaling by WNT 241 3.27e-01 -3.67e-02 4.83e-01
VEGFA-VEGFR2 Pathway 93 5.53e-01 -3.56e-02 6.82e-01
Uptake and actions of bacterial toxins 28 7.45e-01 3.55e-02 8.30e-01
ERBB2 Regulates Cell Motility 10 8.47e-01 3.53e-02 8.98e-01
ADP signalling through P2Y purinoceptor 1 21 7.81e-01 -3.50e-02 8.55e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 1.36e-01 -3.50e-02 2.59e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 8.92e-01 -3.49e-02 9.33e-01
Collagen formation 66 6.26e-01 3.47e-02 7.41e-01
STING mediated induction of host immune responses 15 8.16e-01 -3.46e-02 8.76e-01
FGFR1 ligand binding and activation 10 8.51e-01 -3.44e-02 9.00e-01
RA biosynthesis pathway 13 8.30e-01 -3.43e-02 8.87e-01
RHOC GTPase cycle 72 6.15e-01 3.43e-02 7.34e-01
Serine biosynthesis 8 8.67e-01 3.43e-02 9.11e-01
Intra-Golgi traffic 43 6.98e-01 -3.42e-02 7.95e-01
ESR-mediated signaling 160 4.55e-01 -3.42e-02 6.03e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 8.11e-01 -3.36e-02 8.74e-01
Nicotinate metabolism 26 7.68e-01 3.35e-02 8.47e-01
Apoptotic cleavage of cellular proteins 35 7.33e-01 -3.33e-02 8.21e-01
RAF-independent MAPK1/3 activation 22 7.87e-01 3.33e-02 8.59e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 8.71e-01 3.33e-02 9.14e-01
RHOH GTPase cycle 34 7.41e-01 3.28e-02 8.26e-01
Signaling by FGFR4 32 7.52e-01 -3.22e-02 8.33e-01
Extracellular matrix organization 222 4.09e-01 3.22e-02 5.63e-01
CD163 mediating an anti-inflammatory response 9 8.68e-01 3.20e-02 9.11e-01
TICAM1-dependent activation of IRF3/IRF7 13 8.41e-01 3.20e-02 8.94e-01
Interleukin-17 signaling 68 6.48e-01 -3.20e-02 7.54e-01
Glycosaminoglycan metabolism 98 5.85e-01 -3.20e-02 7.11e-01
RHOA GTPase cycle 139 5.18e-01 3.18e-02 6.57e-01
FOXO-mediated transcription of cell death genes 16 8.28e-01 3.14e-02 8.85e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 6.63e-01 -3.10e-02 7.65e-01
Activation of NMDA receptors and postsynaptic events 74 6.46e-01 3.09e-02 7.52e-01
Cellular responses to mechanical stimuli 82 6.30e-01 -3.08e-02 7.42e-01
Response of endothelial cells to shear stress 82 6.30e-01 -3.08e-02 7.42e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.72e-01 -3.02e-02 7.00e-01
Phospholipase C-mediated cascade; FGFR3 5 9.07e-01 3.01e-02 9.43e-01
Defective RIPK1-mediated regulated necrosis 7 8.91e-01 2.99e-02 9.32e-01
Activation of the AP-1 family of transcription factors 10 8.71e-01 2.96e-02 9.14e-01
Signaling by ERBB2 44 7.35e-01 -2.95e-02 8.23e-01
HSF1-dependent transactivation 30 7.81e-01 -2.93e-02 8.55e-01
Signaling by EGFR 48 7.27e-01 2.91e-02 8.18e-01
Signaling by Activin 14 8.51e-01 -2.90e-02 9.01e-01
Reduction of cytosolic Ca++ levels 9 8.81e-01 2.89e-02 9.23e-01
Extra-nuclear estrogen signaling 67 6.83e-01 -2.88e-02 7.82e-01
GABA synthesis, release, reuptake and degradation 12 8.64e-01 2.85e-02 9.09e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.64e-01 -2.85e-02 9.09e-01
alpha-linolenic acid (ALA) metabolism 12 8.64e-01 -2.85e-02 9.09e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 7.39e-01 2.84e-02 8.25e-01
Molecules associated with elastic fibres 26 8.04e-01 -2.81e-02 8.71e-01
Signaling by Rho GTPases 608 2.40e-01 -2.79e-02 3.91e-01
Formation of the beta-catenin:TCF transactivating complex 44 7.50e-01 -2.77e-02 8.33e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 7.33e-01 2.73e-02 8.21e-01
Oncogene Induced Senescence 33 7.90e-01 2.68e-02 8.62e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.53e-01 -2.67e-02 9.02e-01
Post-translational protein phosphorylation 70 7.01e-01 -2.65e-02 7.97e-01
Formation of the cornified envelope 36 7.83e-01 -2.65e-02 8.56e-01
Glucagon-type ligand receptors 20 8.41e-01 -2.58e-02 8.94e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 9.13e-01 -2.58e-02 9.47e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 7.89e-01 2.58e-02 8.61e-01
VEGFR2 mediated vascular permeability 26 8.21e-01 -2.57e-02 8.78e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 7.60e-01 -2.55e-02 8.39e-01
Signal Transduction 2058 5.75e-02 2.54e-02 1.37e-01
G alpha (i) signalling events 194 5.44e-01 2.53e-02 6.76e-01
TAK1-dependent IKK and NF-kappa-B activation 43 7.75e-01 2.52e-02 8.51e-01
FGFR4 ligand binding and activation 5 9.22e-01 -2.52e-02 9.53e-01
Signaling by Retinoic Acid 29 8.15e-01 -2.52e-02 8.75e-01
Mitochondrial unfolded protein response (UPRmt) 17 8.60e-01 -2.46e-02 9.06e-01
The canonical retinoid cycle in rods (twilight vision) 9 8.99e-01 -2.45e-02 9.36e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 8.21e-01 2.39e-02 8.78e-01
Signaling by Nuclear Receptors 214 5.47e-01 -2.39e-02 6.78e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 8.54e-01 2.38e-02 9.02e-01
Trafficking of AMPA receptors 20 8.54e-01 2.38e-02 9.02e-01
RAB GEFs exchange GTP for GDP on RABs 89 6.98e-01 -2.38e-02 7.95e-01
Common Pathway of Fibrin Clot Formation 13 8.84e-01 2.34e-02 9.26e-01
Elastic fibre formation 33 8.16e-01 2.34e-02 8.76e-01
Generic Transcription Pathway 1088 1.95e-01 -2.33e-02 3.37e-01
Rab regulation of trafficking 122 6.58e-01 -2.32e-02 7.62e-01
RHOD GTPase cycle 50 7.82e-01 2.27e-02 8.55e-01
EPHA-mediated growth cone collapse 21 8.59e-01 2.23e-02 9.06e-01
IFNG signaling activates MAPKs 8 9.16e-01 -2.14e-02 9.49e-01
Biosynthesis of Lipoxins (LX) 6 9.28e-01 -2.14e-02 9.57e-01
EPH-ephrin mediated repulsion of cells 43 8.09e-01 -2.13e-02 8.73e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 9.35e-01 -2.09e-02 9.62e-01
Factors involved in megakaryocyte development and platelet production 129 6.92e-01 2.02e-02 7.90e-01
SHC-mediated cascade:FGFR1 13 9.00e-01 2.01e-02 9.37e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 8.58e-01 -1.99e-02 9.05e-01
Collagen biosynthesis and modifying enzymes 48 8.14e-01 1.96e-02 8.75e-01
RHO GTPases Activate ROCKs 18 8.86e-01 -1.94e-02 9.28e-01
SLC transporter disorders 77 7.71e-01 -1.92e-02 8.49e-01
p38MAPK events 13 9.06e-01 1.89e-02 9.42e-01
Cell death signalling via NRAGE, NRIF and NADE 69 7.93e-01 -1.83e-02 8.64e-01
Signaling by FGFR3 32 8.60e-01 -1.80e-02 9.06e-01
FGFR1b ligand binding and activation 5 9.45e-01 1.78e-02 9.71e-01
RHOQ GTPase cycle 55 8.33e-01 -1.65e-02 8.88e-01
Intracellular signaling by second messengers 268 6.43e-01 -1.64e-02 7.51e-01
IKK complex recruitment mediated by RIP1 23 8.96e-01 -1.58e-02 9.35e-01
Negative regulation of FLT3 15 9.16e-01 -1.58e-02 9.49e-01
The NLRP3 inflammasome 16 9.13e-01 -1.58e-02 9.47e-01
Interleukin-27 signaling 11 9.29e-01 -1.55e-02 9.57e-01
Inactivation of CSF3 (G-CSF) signaling 24 8.96e-01 -1.55e-02 9.35e-01
Post NMDA receptor activation events 64 8.35e-01 1.51e-02 8.89e-01
Semaphorin interactions 56 8.48e-01 -1.48e-02 8.98e-01
Digestion 5 9.54e-01 -1.48e-02 9.75e-01
Platelet homeostasis 69 8.34e-01 -1.46e-02 8.89e-01
G beta:gamma signalling through PI3Kgamma 22 9.06e-01 -1.46e-02 9.42e-01
MyD88 cascade initiated on plasma membrane 95 8.07e-01 1.45e-02 8.71e-01
Toll Like Receptor 10 (TLR10) Cascade 95 8.07e-01 1.45e-02 8.71e-01
Toll Like Receptor 5 (TLR5) Cascade 95 8.07e-01 1.45e-02 8.71e-01
Cytokine Signaling in Immune system 670 5.25e-01 -1.44e-02 6.61e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 9.16e-01 -1.43e-02 9.49e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 9.16e-01 -1.43e-02 9.49e-01
Signaling by NOTCH2 33 8.87e-01 1.42e-02 9.29e-01
Maturation of nucleoprotein 9694631 15 9.24e-01 -1.42e-02 9.55e-01
Scavenging by Class F Receptors 5 9.56e-01 1.41e-02 9.77e-01
Cobalamin (Cbl) metabolism 7 9.49e-01 1.40e-02 9.72e-01
Signaling by MAPK mutants 6 9.53e-01 -1.39e-02 9.75e-01
G-protein beta:gamma signalling 29 8.98e-01 1.37e-02 9.36e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.47e-01 -1.36e-02 9.71e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 8.36e-01 -1.35e-02 8.90e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 9.48e-01 -1.34e-02 9.71e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.52e-01 1.33e-02 9.74e-01
FGFR2 ligand binding and activation 9 9.46e-01 1.31e-02 9.71e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 8.15e-01 -1.31e-02 8.75e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 8.99e-01 -1.30e-02 9.36e-01
Transport of fatty acids 5 9.61e-01 -1.27e-02 9.78e-01
Synthesis of UDP-N-acetyl-glucosamine 8 9.51e-01 1.25e-02 9.74e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 9.21e-01 1.23e-02 9.53e-01
Platelet calcium homeostasis 22 9.25e-01 -1.16e-02 9.55e-01
SLC-mediated transmembrane transport 175 7.97e-01 -1.13e-02 8.65e-01
Signaling by TGF-beta Receptor Complex 91 8.57e-01 -1.09e-02 9.04e-01
SUMO E3 ligases SUMOylate target proteins 161 8.13e-01 1.08e-02 8.75e-01
G alpha (z) signalling events 36 9.12e-01 1.07e-02 9.47e-01
MAPK family signaling cascades 264 7.68e-01 -1.05e-02 8.47e-01
Passive transport by Aquaporins 6 9.65e-01 1.04e-02 9.79e-01
Keratan sulfate/keratin metabolism 28 9.25e-01 1.03e-02 9.55e-01
Phase I - Functionalization of compounds 70 8.91e-01 -9.47e-03 9.32e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 9.61e-01 -9.35e-03 9.78e-01
Signalling to ERKs 32 9.32e-01 8.72e-03 9.60e-01
Signaling by ERBB4 45 9.21e-01 -8.51e-03 9.53e-01
Interleukin-35 Signalling 12 9.61e-01 8.16e-03 9.78e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.75e-01 -7.98e-03 9.84e-01
Induction of Cell-Cell Fusion 8 9.70e-01 7.72e-03 9.83e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 9.75e-01 -7.44e-03 9.84e-01
Pre-NOTCH Transcription and Translation 47 9.32e-01 7.15e-03 9.60e-01
Calcineurin activates NFAT 9 9.72e-01 6.80e-03 9.84e-01
Trafficking and processing of endosomal TLR 13 9.67e-01 -6.63e-03 9.80e-01
Metabolism of steroids 125 9.00e-01 -6.49e-03 9.37e-01
SHC-mediated cascade:FGFR3 10 9.72e-01 6.42e-03 9.84e-01
Triglyceride catabolism 16 9.65e-01 6.40e-03 9.79e-01
Keratinization 37 9.47e-01 -6.28e-03 9.71e-01
ECM proteoglycans 48 9.40e-01 6.24e-03 9.67e-01
ERK/MAPK targets 22 9.61e-01 -6.08e-03 9.78e-01
Cargo concentration in the ER 31 9.54e-01 5.95e-03 9.75e-01
Metal ion SLC transporters 19 9.65e-01 -5.81e-03 9.79e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.74e-01 5.76e-03 9.84e-01
RHO GTPases activate PAKs 20 9.65e-01 5.71e-03 9.79e-01
ChREBP activates metabolic gene expression 7 9.80e-01 5.57e-03 9.88e-01
Signaling by Receptor Tyrosine Kinases 449 8.44e-01 -5.43e-03 8.96e-01
Synthesis of PA 31 9.59e-01 5.32e-03 9.78e-01
MITF-M-regulated melanocyte development 113 9.27e-01 5.02e-03 9.56e-01
TBC/RABGAPs 45 9.58e-01 -4.52e-03 9.78e-01
ADORA2B mediated anti-inflammatory cytokines production 36 9.63e-01 -4.43e-03 9.79e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 9.76e-01 -4.29e-03 9.84e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 9.76e-01 -4.29e-03 9.84e-01
HDR through MMEJ (alt-NHEJ) 12 9.81e-01 -4.04e-03 9.88e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 9.80e-01 -3.95e-03 9.88e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 9.86e-01 3.83e-03 9.92e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 9.88e-01 3.58e-03 9.93e-01
TGFBR1 KD Mutants in Cancer 6 9.88e-01 3.58e-03 9.93e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 9.73e-01 -3.55e-03 9.84e-01
Signaling by MET 68 9.66e-01 2.95e-03 9.80e-01
SUMOylation 167 9.61e-01 2.20e-03 9.78e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 9.46e-01 -1.95e-03 9.71e-01
RND1 GTPase cycle 37 9.84e-01 1.91e-03 9.90e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 9.91e-01 1.71e-03 9.94e-01
Cellular hexose transport 14 9.92e-01 -1.54e-03 9.95e-01
Zinc influx into cells by the SLC39 gene family 9 9.94e-01 1.50e-03 9.96e-01
Pre-NOTCH Expression and Processing 63 9.84e-01 1.48e-03 9.90e-01
N-Glycan antennae elongation 13 9.93e-01 1.47e-03 9.95e-01
Interferon gamma signaling 90 9.91e-01 -7.20e-04 9.94e-01
Erythropoietin activates STAT5 6 9.98e-01 5.15e-04 9.99e-01
Estrogen-dependent gene expression 97 9.97e-01 -2.28e-04 9.98e-01
Formation of the nephric duct 8 9.99e-01 1.82e-04 1.00e+00
Phosphate bond hydrolysis by NTPDase proteins 5 1.00e+00 -7.27e-05 1.00e+00


Detailed Gene set reports



Formation of ATP by chemiosmotic coupling
set Formation of ATP by chemiosmotic coupling
setSize 20
pANOVA 3.91e-11
s.dist -0.853
p.adjustANOVA 6.75e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5MK -10379
ATP5MG -10104
ATP5F1C -10016
ATP5F1E -10001
ATP5MC1 -9956
ATP5PO -9870
ATP5PB -9734
ATP5PD -9683
ATP5PF -9667
ATP5F1A -9448
ATP5F1B -9412
ATP5MC2 -9310
MT-ATP6 -8913
ATP5MF -8778
ATP5MJ -8412
ATP5MC3 -8105
DMAC2L -8047
ATP5F1D -7279
ATP5ME -5433
MT-ATP8 -5196

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MK -10379
ATP5MG -10104
ATP5F1C -10016
ATP5F1E -10001
ATP5MC1 -9956
ATP5PO -9870
ATP5PB -9734
ATP5PD -9683
ATP5PF -9667
ATP5F1A -9448
ATP5F1B -9412
ATP5MC2 -9310
MT-ATP6 -8913
ATP5MF -8778
ATP5MJ -8412
ATP5MC3 -8105
DMAC2L -8047
ATP5F1D -7279
ATP5ME -5433
MT-ATP8 -5196


Peptide chain elongation
set Peptide chain elongation
setSize 88
pANOVA 1.15e-42
s.dist -0.843
p.adjustANOVA 1.31e-40


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
EEF1A1 -9699
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EEF2 -7219
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
RPL9 -211
RPL3L 556
RPS26 7855


Formation of a pool of free 40S subunits
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 3.11e-48
s.dist -0.842
p.adjustANOVA 4.29e-46


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
EIF3E -9855
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
EIF3K -9763
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
EIF3I -9538
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
EIF3L -9325
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPL36AL -6618
RPS16 -6448
EIF1AX -6419
RPL9 -211
RPL3L 556
RPS26 7855


Eukaryotic Translation Elongation
set Eukaryotic Translation Elongation
setSize 93
pANOVA 3.7e-44
s.dist -0.834
p.adjustANOVA 4.47e-42


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
EEF1A1 -9699
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
EEF1B2 -9599
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
EEF1G -9228
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
EEF1A1P5 -8838
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
RPS2 -7849
EEF1D -7497
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EEF2 -7219
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
RPL9 -211
EEF1A2 -106
RPL3L 556
RPS26 7855


Viral mRNA Translation
set Viral mRNA Translation
setSize 88
pANOVA 1.49e-41
s.dist -0.831
p.adjustANOVA 1.6e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
GRSF1 -9525
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
RPL9 -211
RPL3L 556
DNAJC3 3671
RPS26 7855


L13a-mediated translational silencing of Ceruloplasmin expression
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 6.06e-51
s.dist -0.826
p.adjustANOVA 1.17e-48


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
EIF3E -9855
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
EIF3K -9763
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
EIF3I -9538
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
EIF4A1 -9230
RPS19 -9141
RPL23A -9123
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPL36AL -6618
RPS16 -6448
EIF1AX -6419
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
RPL9 -211
RPL3L 556
EIF4G1 782
RPS26 7855


Modulation by Mtb of host immune system
set Modulation by Mtb of host immune system
setSize 7
pANOVA 0.000153
s.dist -0.826
p.adjustANOVA 0.000877


Top enriched genes
Top 20 genes
GeneID Gene Rank
B2M -10299
UBC -9921
UBA52 -9492
RPS27A -9092
MRC1 -8237
TLR2 -7509
UBB -5641

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B2M -10299
UBC -9921
UBA52 -9492
RPS27A -9092
MRC1 -8237
TLR2 -7509
UBB -5641


GTP hydrolysis and joining of the 60S ribosomal subunit
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 7.36e-51
s.dist -0.822
p.adjustANOVA 1.29e-48


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
EIF3E -9855
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
EIF3K -9763
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
EIF3I -9538
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
EIF4A1 -9230
RPS19 -9141
RPL23A -9123
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
RPL38 -8565
EIF5 -8530
RPL39L -8439
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPL36AL -6618
RPS16 -6448
EIF1AX -6419
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
EIF5B -4211
RPL9 -211
RPL3L 556
EIF4G1 782
RPS26 7855


SARS-CoV-1 modulates host translation machinery
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 1.72e-17
s.dist -0.819
p.adjustANOVA 5.93e-16


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
RPS24 -9901
RPS15A -9863
RPS6 -9824
RPS23 -9736
EEF1A1 -9699
RPS27 -9689
RPSA -9567
RPS9 -9545
RPS3 -9513
RPS11 -9342
RPS10 -9273
RPS19 -9141
RPS27A -9092

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
RPS24 -9901
RPS15A -9863
RPS6 -9824
RPS23 -9736
EEF1A1 -9699
RPS27 -9689
RPSA -9567
RPS9 -9545
RPS3 -9513
RPS11 -9342
RPS10 -9273
RPS19 -9141
RPS27A -9092
HNRNPA1 -9025
FAU -8964
RPS15 -8795
RPS27L -8745
RPS17 -8642
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPS14 -8102
RPS2 -7849
RPS29 -7204
RPS4Y1 -7139
RPS21 -6829
RPS28 -6698
RPS16 -6448
RPS26 7855


Cap-dependent Translation Initiation
set Cap-dependent Translation Initiation
setSize 118
pANOVA 2.87e-53
s.dist -0.817
p.adjustANOVA 6.17e-51


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
EIF3E -9855
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
EIF3K -9763
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
EIF3I -9538
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
EIF4A1 -9230
RPS19 -9141
RPL23A -9123
RPS27A -9092
EIF3D -9076
EIF2B2 -9052
FAU -8964
EIF3G -8961
EIF3J -8885
RPL3 -8848
EIF2B1 -8804
RPS15 -8795
RPL26L1 -8788
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
RPL38 -8565
EIF5 -8530
RPL39L -8439
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPL36AL -6618
RPS16 -6448
EIF1AX -6419
EIF2B3 -6023
EIF2B4 -5451
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
EIF5B -4211
EIF2B5 -3130
RPL9 -211
RPL3L 556
EIF4G1 782
RPS26 7855


Eukaryotic Translation Initiation
set Eukaryotic Translation Initiation
setSize 118
pANOVA 2.87e-53
s.dist -0.817
p.adjustANOVA 6.17e-51


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
EIF3E -9855
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
EIF3K -9763
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
EIF3I -9538
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
EIF4A1 -9230
RPS19 -9141
RPL23A -9123
RPS27A -9092
EIF3D -9076
EIF2B2 -9052
FAU -8964
EIF3G -8961
EIF3J -8885
RPL3 -8848
EIF2B1 -8804
RPS15 -8795
RPL26L1 -8788
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
RPL38 -8565
EIF5 -8530
RPL39L -8439
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPL36AL -6618
RPS16 -6448
EIF1AX -6419
EIF2B3 -6023
EIF2B4 -5451
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
EIF5B -4211
EIF2B5 -3130
RPL9 -211
RPL3L 556
EIF4G1 782
RPS26 7855


Formation of the ternary complex, and subsequently, the 43S complex
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 9.14e-24
s.dist -0.813
p.adjustANOVA 3.92e-22


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
RPSA -9567
RPS9 -9545
EIF3I -9538
RPS3 -9513

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
RPSA -9567
RPS9 -9545
EIF3I -9538
RPS3 -9513
RPS11 -9342
EIF3L -9325
RPS10 -9273
RPS19 -9141
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPS15 -8795
EIF2S3 -8787
RPS27L -8745
RPS17 -8642
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPS16 -6448
EIF1AX -6419
EIF2S1 -4352
RPS26 7855


Eukaryotic Translation Termination
set Eukaryotic Translation Termination
setSize 92
pANOVA 2.94e-41
s.dist -0.81
p.adjustANOVA 2.84e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
TRMT112 -9205
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
APEH -8185
RPL37 -8133
RPS14 -8102
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
GSPT1 -2717
ETF1 -2337
GSPT2 -1662
RPL9 -211
RPL3L 556
N6AMT1 5291
RPS26 7855


Mitochondrial translation initiation
set Mitochondrial translation initiation
setSize 90
pANOVA 4.02e-40
s.dist -0.807
p.adjustANOVA 3.24e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
MTIF2 -9774
MRPL11 -9723

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
MTIF2 -9774
MRPL11 -9723
MRPL45 -9714
MRPL12 -9704
MRPL48 -9656
MRPL46 -9616
MRPL20 -9597
CHCHD1 -9554
MRPS27 -9510
MRPS18B -9490
MRPL44 -9483
MRPS18C -9472
MRPL16 -9444
GADD45GIP1 -9420
MRPL52 -9359
MRPL24 -9309
MRPL36 -9298
MRPL54 -9274
MRPS17 -9266
MRPS11 -9135
MRPL53 -9119
MRPS35 -9046
MRPL58 -9020
MRPS5 -9019
MTIF3 -8993
MRPL27 -8986
OXA1L -8897
MRPL9 -8851
MRPS26 -8775
MRPL18 -8751
MRPS23 -8641
MRPL49 -8602
PTCD3 -8572
MRPL4 -8531
MRPL14 -8516
MRPL47 -8492
MRPS24 -8475
MRPS18A -8449
MRPS2 -8399
MRPL23 -8375
RPS12 -8238
MTFMT -8156
MRPL21 -8108
MRPL55 -8074
MRPS14 -8019
ERAL1 -7966
MRPS34 -7830
MRPL13 -7769
MRPL43 -7617
MRPL22 -7417
MRPL33 -7353
MRPS9 -7311
MRPS30 -7283
MRPL10 -7218
AURKAIP1 -7163
MRPL38 -7020
MRPS33 -7000
MRPL1 -6879
MRPS36 -6781
MRPL19 -6742
MRPS25 -6379
MRPL28 -6205
MRPL30 -6129
MRPS10 -6116
MRPL39 -5937
MRPS31 -5589
MRPL35 -5551
MRPL2 -5521
MRPL41 -5085
MRPL42 -3938
MRPL50 -1529
MRPS6 3568


SRP-dependent cotranslational protein targeting to membrane
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 6.91e-49
s.dist -0.805
p.adjustANOVA 1.03e-46


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
SEC11A -10173
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
SPCS1 -9984
RPL14 -9979
RPL10A -9943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
SEC11A -10173
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
SPCS1 -9984
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
SSR2 -9869
RPS15A -9863
RPL8 -9828
RPS6 -9824
SSR3 -9814
RPL34 -9793
RPL23 -9781
SRPRB -9772
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
SSR4 -9402
RPL18A -9380
SRP14 -9354
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPN1 -9288
RPS10 -9273
RPL27A -9268
RPN2 -9208
RPS19 -9141
RPL23A -9123
SRP72 -9096
RPS27A -9092
SEC11C -9091
DDOST -9050
FAU -8964
RPL3 -8848
SRP9 -8845
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
SEC61G -8479
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
SEC61A1 -8132
RPS14 -8102
SEC61B -8032
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
TRAM1 -7257
SRP68 -7245
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
SPCS2 -7055
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
SRP19 -4244
SPCS3 -3043
SSR1 -1071
SRP54 -996
RPL9 -211
RPL3L 556
SRPRA 2035
SEC61A2 4645
RPS26 7855


Selenocysteine synthesis
set Selenocysteine synthesis
setSize 92
pANOVA 9.69e-41
s.dist -0.805
p.adjustANOVA 8.14e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
EEFSEC -8494
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
SARS1 -6943
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
SECISBP2 -1781
RPL9 -211
PSTK -117
RPL3L 556
SEPHS2 1631
SEPSECS 2236
RPS26 7855


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 2.37e-41
s.dist -0.802
p.adjustANOVA 2.41e-39


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
NCBP2 -7939
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
GSPT1 -2717
ETF1 -2337
UPF1 -2229
NCBP1 -1909
GSPT2 -1662
RPL9 -211
RPL3L 556
EIF4G1 782
RPS26 7855


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 3.26e-26
s.dist -0.796
p.adjustANOVA 1.54e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
PABPC1 -9587
RPSA -9567
RPS9 -9545

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
PABPC1 -9587
RPSA -9567
RPS9 -9545
EIF3I -9538
RPS3 -9513
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPS10 -9273
EIF4A1 -9230
RPS19 -9141
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPS15 -8795
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPS16 -6448
EIF1AX -6419
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
EIF4G1 782
RPS26 7855


Mitochondrial translation elongation
set Mitochondrial translation elongation
setSize 90
pANOVA 7.27e-39
s.dist -0.794
p.adjustANOVA 4.84e-37


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
TSFM -9743
MRPL11 -9723

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
TSFM -9743
MRPL11 -9723
MRPL45 -9714
MRPL12 -9704
MRPL48 -9656
MRPL46 -9616
MRPL20 -9597
CHCHD1 -9554
MRPS27 -9510
MRPS18B -9490
MRPL44 -9483
MRPS18C -9472
MRPL16 -9444
GADD45GIP1 -9420
MRPL52 -9359
MRPL24 -9309
MRPL36 -9298
MRPL54 -9274
MRPS17 -9266
MRPS11 -9135
MRPL53 -9119
MRPS35 -9046
MRPL58 -9020
MRPS5 -9019
MRPL27 -8986
OXA1L -8897
MRPL9 -8851
MRPS26 -8775
MRPL18 -8751
MRPS23 -8641
TUFM -8624
MRPL49 -8602
PTCD3 -8572
MRPL4 -8531
MRPL14 -8516
MRPL47 -8492
MRPS24 -8475
MRPS18A -8449
MRPS2 -8399
MRPL23 -8375
RPS12 -8238
MRPL21 -8108
MRPL55 -8074
MRPS14 -8019
ERAL1 -7966
MRPS34 -7830
MRPL13 -7769
MRPL43 -7617
MRPL22 -7417
MRPL33 -7353
MRPS9 -7311
MRPS30 -7283
MRPL10 -7218
AURKAIP1 -7163
MRPL38 -7020
MRPS33 -7000
MRPL1 -6879
MRPS36 -6781
MRPL19 -6742
MRPS25 -6379
MRPL28 -6205
MRPL30 -6129
MRPS10 -6116
MRPL39 -5937
MRPS31 -5589
MRPL35 -5551
MRPL2 -5521
MRPL41 -5085
MRPL42 -3938
MRPL50 -1529
MRPS6 3568
GFM1 4523


Translation initiation complex formation
set Translation initiation complex formation
setSize 58
pANOVA 1.32e-25
s.dist -0.793
p.adjustANOVA 6.06e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
PABPC1 -9587
RPSA -9567
RPS9 -9545
EIF3I -9538

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
PABPC1 -9587
RPSA -9567
RPS9 -9545
EIF3I -9538
RPS3 -9513
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPS10 -9273
EIF4A1 -9230
RPS19 -9141
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPS15 -8795
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPS16 -6448
EIF1AX -6419
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
EIF4G1 782
RPS26 7855


Ribosomal scanning and start codon recognition
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 1.66e-25
s.dist -0.791
p.adjustANOVA 7.46e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
RPSA -9567
RPS9 -9545
EIF3I -9538
RPS3 -9513

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3M -10391
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
EIF3H -9903
RPS24 -9901
RPS15A -9863
EIF3E -9855
RPS6 -9824
EIF3K -9763
RPS23 -9736
RPS27 -9689
RPSA -9567
RPS9 -9545
EIF3I -9538
RPS3 -9513
EIF4B -9348
RPS11 -9342
EIF3L -9325
RPS10 -9273
EIF4A1 -9230
RPS19 -9141
RPS27A -9092
EIF3D -9076
FAU -8964
EIF3G -8961
EIF3J -8885
RPS15 -8795
EIF2S3 -8787
RPS27L -8745
EIF4H -8740
RPS17 -8642
EIF5 -8530
RPS5 -8386
EIF3B -8353
RPS18 -8328
RPS12 -8238
RPS14 -8102
EIF2S2 -8034
RPS2 -7849
EIF3C -7213
RPS29 -7204
RPS4Y1 -7139
RPS21 -6829
EIF3A -6824
EIF3F -6729
RPS28 -6698
RPS16 -6448
EIF1AX -6419
EIF4A2 -5245
EIF4E -5066
EIF2S1 -4352
EIF4G1 782
RPS26 7855


Mitochondrial translation termination
set Mitochondrial translation termination
setSize 90
pANOVA 6.58e-38
s.dist -0.783
p.adjustANOVA 4.24e-36


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
MRPL11 -9723
MRPL45 -9714

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
MRPL11 -9723
MRPL45 -9714
MRPL12 -9704
MRPL48 -9656
MRPL46 -9616
MRPL20 -9597
CHCHD1 -9554
MRPS27 -9510
MRPS18B -9490
MRPL44 -9483
MRPS18C -9472
MRPL16 -9444
GADD45GIP1 -9420
MRPL52 -9359
MRPL24 -9309
MRPL36 -9298
MRPL54 -9274
MRPS17 -9266
MRPS11 -9135
MRPL53 -9119
MRPS35 -9046
MRPL58 -9020
MRPS5 -9019
MRPL27 -8986
OXA1L -8897
MRPL9 -8851
MRPS26 -8775
MRPL18 -8751
MRRF -8705
MRPS23 -8641
MRPL49 -8602
PTCD3 -8572
MRPL4 -8531
MRPL14 -8516
MRPL47 -8492
MRPS24 -8475
MRPS18A -8449
MRPS2 -8399
MRPL23 -8375
RPS12 -8238
MRPL21 -8108
MRPL55 -8074
MRPS14 -8019
ERAL1 -7966
MRPS34 -7830
MRPL13 -7769
MRPL43 -7617
MRPL22 -7417
MRPL33 -7353
MRPS9 -7311
MRPS30 -7283
MRPL10 -7218
AURKAIP1 -7163
MRPL38 -7020
MRPS33 -7000
MRPL1 -6879
MRPS36 -6781
MRPL19 -6742
MRPS25 -6379
MRPL28 -6205
MRPL30 -6129
MRPS10 -6116
MRPL39 -5937
MRPS31 -5589
MRPL35 -5551
MRPL2 -5521
MRPL41 -5085
MRPL42 -3938
MRPL50 -1529
GFM2 -152
MRPS6 3568
MTRF1L 5122


Mitochondrial translation
set Mitochondrial translation
setSize 96
pANOVA 1.31e-39
s.dist -0.776
p.adjustANOVA 9.37e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
MTIF2 -9774
TSFM -9743

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
MRPS15 -10132
MRPL51 -10127
MRPS22 -10100
MRPS7 -10039
DAP3 -10029
MRPL40 -9938
MRPL17 -9914
MRPL32 -9896
MRPL57 -9893
MRPL34 -9811
MTIF2 -9774
TSFM -9743
MRPL11 -9723
MRPL45 -9714
MRPL12 -9704
MRPL48 -9656
MRPL46 -9616
MRPL20 -9597
CHCHD1 -9554
MRPS27 -9510
MRPS18B -9490
MRPL44 -9483
MRPS18C -9472
MRPL16 -9444
GADD45GIP1 -9420
MRPL52 -9359
MRPL24 -9309
MRPL36 -9298
MRPL54 -9274
MRPS17 -9266
MRPS11 -9135
MRPL53 -9119
MRPS35 -9046
MRPL58 -9020
MRPS5 -9019
MTIF3 -8993
MRPL27 -8986
OXA1L -8897
MRPL9 -8851
MRPS26 -8775
MRPL18 -8751
MRRF -8705
MRPS23 -8641
TUFM -8624
MRPL49 -8602
PTCD3 -8572
MRPL4 -8531
MRPL14 -8516
MRPL47 -8492
MRPS24 -8475
MRPS18A -8449
MRPS2 -8399
MRPL23 -8375
RPS12 -8238
MTFMT -8156
MRPL21 -8108
MRPL55 -8074
MRPS14 -8019
ERAL1 -7966
MRPS34 -7830
MRPL13 -7769
MRPL43 -7617
MRPL22 -7417
MRPL33 -7353
MRPS9 -7311
MRPS30 -7283
MRPL10 -7218
AURKAIP1 -7163
MRPL38 -7020
MRPS33 -7000
MRPL1 -6879
MRPS36 -6781
MRPL19 -6742
MRPS25 -6379
MRPL28 -6205
MRPL30 -6129
MRPS10 -6116
MRPL39 -5937
MRPS31 -5589
MRPL35 -5551
MRPL2 -5521
MRPL41 -5085
MRPL42 -3938
MRPL50 -1529
GFM2 -152
MRPS6 3568
GFM1 4523
MTRF1L 5122


Response of EIF2AK4 (GCN2) to amino acid deficiency
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 5.86e-40
s.dist -0.764
p.adjustANOVA 4.39e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
ATF4 -10009
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
ATF4 -10009
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
EIF2AK4 -9398
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
EIF2S3 -8787
RPS27L -8745
RPS17 -8642
RPL38 -8565
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
EIF2S2 -8034
DDIT3 -7886
RPS2 -7849
CEBPG -7797
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RPS21 -6829
RPS28 -6698
RPL36AL -6618
IMPACT -6560
RPS16 -6448
EIF2S1 -4352
TRIB3 -2985
ATF2 -299
RPL9 -211
RPL3L 556
GCN1 5857
CEBPB 7591
RPS26 7855
ATF3 8370
ASNS 8833


Complex III assembly
set Complex III assembly
setSize 23
pANOVA 2.46e-10
s.dist -0.762
p.adjustANOVA 3.71e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
UQCRH -10423
FXN -10242
UQCRC2 -10164
HSCB -10019
UQCRB -9948
LYRM4 -9848
UQCRQ -9528
UQCR11 -9447
CYC1 -8947
UQCRC1 -8808
UQCRFS1 -8741
ISCU -8155
UQCR10 -8057
UQCC2 -7905
UQCC1 -7796
MT-CYB -7734
UQCC3 -7499
TTC19 -6616
BCS1L -6310
HSPA9 -5918

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UQCRH -10423
FXN -10242
UQCRC2 -10164
HSCB -10019
UQCRB -9948
LYRM4 -9848
UQCRQ -9528
UQCR11 -9447
CYC1 -8947
UQCRC1 -8808
UQCRFS1 -8741
ISCU -8155
UQCR10 -8057
UQCC2 -7905
UQCC1 -7796
MT-CYB -7734
UQCC3 -7499
TTC19 -6616
BCS1L -6310
HSPA9 -5918
LETM1 -4666
LYRM7 -2495
NFS1 -2127


Phosphate bond hydrolysis by NUDT proteins
set Phosphate bond hydrolysis by NUDT proteins
setSize 7
pANOVA 0.000594
s.dist -0.749
p.adjustANOVA 0.00297


Top enriched genes
Top 20 genes
GeneID Gene Rank
NUDT16 -10283
ADPRM -9913
NUDT1 -9395
NUDT15 -8716
NUDT5 -7240
NUDT18 -6890
NUDT9 -1841

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUDT16 -10283
ADPRM -9913
NUDT1 -9395
NUDT15 -8716
NUDT5 -7240
NUDT18 -6890
NUDT9 -1841


SUMO is conjugated to E1 (UBA2:SAE1)
set SUMO is conjugated to E1 (UBA2:SAE1)
setSize 5
pANOVA 0.00398
s.dist -0.744
p.adjustANOVA 0.0157


Top enriched genes
Top 20 genes
GeneID Gene Rank
SAE1 -10054
SUMO2 -8085
SUMO3 -7807
UBA2 -7335
SUMO1 -5166

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SAE1 -10054
SUMO2 -8085
SUMO3 -7807
UBA2 -7335
SUMO1 -5166


Arachidonate production from DAG
set Arachidonate production from DAG
setSize 5
pANOVA 0.0041
s.dist -0.741
p.adjustANOVA 0.016


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABHD6 -10223
ABHD12 -10050
MGLL -9859
DAGLB -6291
DAGLA -1898

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABHD6 -10223
ABHD12 -10050
MGLL -9859
DAGLB -6291
DAGLA -1898


Translation
set Translation
setSize 293
pANOVA 5.08e-104
s.dist -0.732
p.adjustANOVA 9.81e-101


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
EIF3M -10391
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
SEC11A -10173
RPL24 -10168
RPL22L1 -10141
MRPS15 -10132
MRPL51 -10127
RPL4 -10112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MRPL15 -10455
MRPL37 -10431
MRPL3 -10393
EIF3M -10391
MRPS21 -10336
MRPS16 -10322
MRPS28 -10276
EIF4EBP1 -10210
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
SEC11A -10173
RPL24 -10168
RPL22L1 -10141
MRPS15 -10132
MRPL51 -10127
RPL4 -10112
MRPS22 -10100
RPS3A -10095
RPL5 -10093
RPS4X -10091
AIMP2 -10056
RPL36A -10048
MRPS7 -10039
DAP3 -10029
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
SPCS1 -9984
RPL14 -9979
RPL10A -9943
MRPL40 -9938
RPS8 -9927
MRPL17 -9914
EIF3H -9903
RPS24 -9901
MRPL32 -9896
RPL7A -9895
RPL12 -9894
MRPL57 -9893
RPL15 -9885
RPL27 -9879
SSR2 -9869
RPS15A -9863
EIF3E -9855
RPL8 -9828
RPS6 -9824
SSR3 -9814
MRPL34 -9811
RPL34 -9793
RPL23 -9781
MTIF2 -9774
SRPRB -9772
EIF3K -9763
RPL26 -9747
TSFM -9743
RPS23 -9736
MRPL11 -9723
MRPL45 -9714
MRPL12 -9704
EEF1A1 -9699
RPS27 -9689
MRPL48 -9656
KARS1 -9654
RPL32 -9631
RPL11 -9621
MRPL46 -9616
RPL22 -9606
RPL18 -9600
EEF1B2 -9599
MRPL20 -9597
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
CHCHD1 -9554
RPS9 -9545
EIF3I -9538
RPL37A -9537
RPL10 -9522
RPS3 -9513
MRPS27 -9510
UBA52 -9492
MRPS18B -9490
RPL13A -9485
MRPL44 -9483
MRPS18C -9472
RPL31 -9466
PPA1 -9451
MRPL16 -9444
RPL39 -9434
GADD45GIP1 -9420
RPL41 -9414
SSR4 -9402
RPL18A -9380
MRPL52 -9359
SRP14 -9354
EIF4B -9348
RPS11 -9342
DARS1 -9330
EIF3L -9325
RPL35 -9315
MRPL24 -9309
RPLP0 -9306
MRPL36 -9298
RPN1 -9288
MRPL54 -9274
RPS10 -9273
RPL27A -9268
MRPS17 -9266
EIF4A1 -9230
EEF1G -9228
RPN2 -9208
TRMT112 -9205
RPS19 -9141
MRPS11 -9135
RPL23A -9123
MRPL53 -9119
WARS2 -9099
SRP72 -9096
RPS27A -9092
SEC11C -9091
EIF3D -9076
EIF2B2 -9052
DDOST -9050
MRPS35 -9046
MRPL58 -9020
MRPS5 -9019
MTIF3 -8993
MRPL27 -8986
FAU -8964
EIF3G -8961
EEF1E1 -8915
OXA1L -8897
EIF3J -8885
MRPL9 -8851
RPL3 -8848
SRP9 -8845
EEF1A1P5 -8838
EIF2B1 -8804
RPS15 -8795
RPL26L1 -8788
EIF2S3 -8787
MRPS26 -8775
RARS2 -8752
MRPL18 -8751
RPS27L -8745
EIF4H -8740
MRRF -8705
AIMP1 -8671
RPS17 -8642
MRPS23 -8641
TUFM -8624
MRPL49 -8602
PTCD3 -8572
RPL38 -8565
MRPL4 -8531
EIF5 -8530
FARSA -8520
MRPL14 -8516
MRPL47 -8492
SEC61G -8479
MRPS24 -8475
MRPS18A -8449
RPL39L -8439
MRPS2 -8399
RPS5 -8386
MRPL23 -8375
EIF3B -8353
RPS18 -8328
RPS12 -8238
APEH -8185
MTFMT -8156
RPL37 -8133
SEC61A1 -8132
MRPL21 -8108
RPS14 -8102
MRPL55 -8074
EIF2S2 -8034
SEC61B -8032
MRPS14 -8019
SARS2 -7978
ERAL1 -7966
FARSB -7920
RARS1 -7900
RPS2 -7849
MRPS34 -7830
MRPL13 -7769
QARS1 -7691
PPA2 -7622
MRPL43 -7617
EEF1D -7497
RPL36 -7434
MRPL22 -7417
RPL28 -7372
FARS2 -7371
MRPL33 -7353
RPL13 -7349
MRPS9 -7311
MRPS30 -7283
NARS1 -7268
TRAM1 -7257
SRP68 -7245
RPLP2 -7225
EEF2 -7219
MRPL10 -7218
EIF3C -7213
RPS29 -7204
YARS2 -7183
AURKAIP1 -7163
RPS4Y1 -7139
RPLP1 -7064
SPCS2 -7055
MRPL38 -7020
MRPS33 -7000
SARS1 -6943
TARS2 -6894
MRPL1 -6879
RPS21 -6829
EIF3A -6824
MRPS36 -6781
MRPL19 -6742
EIF3F -6729
RPS28 -6698
RPL36AL -6618
MARS2 -6554
RPS16 -6448
EIF1AX -6419
MRPS25 -6379
IARS2 -6295
MRPL28 -6205
MRPL30 -6129
MRPS10 -6116
HARS1 -6056
EIF2B3 -6023
MRPL39 -5937
EPRS1 -5843
GARS1 -5760
MRPS31 -5589
MRPL35 -5551
MRPL2 -5521
EARS2 -5510
EIF2B4 -5451
EIF4A2 -5245
VARS1 -5121
MRPL41 -5085
EIF4E -5066
EIF2S1 -4352
VARS2 -4297
SRP19 -4244
EIF5B -4211
MRPL42 -3938
DARS2 -3605
LARS1 -3519
CARS1 -3180
EIF2B5 -3130
SPCS3 -3043
GSPT1 -2717
ETF1 -2337
GSPT2 -1662
MRPL50 -1529
PARS2 -1330
SSR1 -1071
SRP54 -996
AARS1 -395
HARS2 -370
NARS2 -267
RPL9 -211
GFM2 -152
TARS1 -115
EEF1A2 -106
RPL3L 556
EIF4G1 782
YARS1 840
AARS2 1661
SRPRA 2035
IARS1 2871
MRPS6 3568
MARS1 3601
GFM1 4523
SEC61A2 4645
MTRF1L 5122
N6AMT1 5291
LARS2 5587
RPS26 7855
CARS2 8490
WARS1 9451


SARS-CoV-2 modulates host translation machinery
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 8.66e-19
s.dist -0.73
p.adjustANOVA 3.16e-17


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
RPS24 -9901
RPS15A -9863
RPS6 -9824
SNRPE -9818
SNRPD1 -9791
RPS23 -9736
RPS27 -9689
RPSA -9567
RPS9 -9545
RPS3 -9513
RPS11 -9342
RPS10 -9273
RPS19 -9141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPS3A -10095
RPS4X -10091
RPS20 -10024
RPS25 -10002
RPS8 -9927
RPS24 -9901
RPS15A -9863
RPS6 -9824
SNRPE -9818
SNRPD1 -9791
RPS23 -9736
RPS27 -9689
RPSA -9567
RPS9 -9545
RPS3 -9513
RPS11 -9342
RPS10 -9273
RPS19 -9141
RPS27A -9092
FAU -8964
SNRPB -8905
RPS15 -8795
RPS27L -8745
RPS17 -8642
SNRPD2 -8504
GEMIN6 -8391
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPS14 -8102
RPS2 -7849
SNRPG -7577
RPS29 -7204
RPS4Y1 -7139
RPS21 -6829
RPS28 -6698
RPS16 -6448
SNRPD3 -5162
SNRPF -5084
GEMIN4 -4810
DDX20 -4043
SMN1 -3915
GEMIN2 -3760
GEMIN5 -2452
GEMIN7 -2039
GEMIN8 2953
RPS26 7855


FASTK family proteins regulate processing and stability of mitochondrial RNAs
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 19
pANOVA 4.07e-08
s.dist -0.727
p.adjustANOVA 4.34e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MT-ND2 -10254
MT-ND3 -10178
MT-ND1 -10175
MT-CO2 -9586
MT-CO3 -9084
MT-ATP6 -8913
MT-ND4L -8461
MT-CYB -7734
TBRG4 -7522
MT-ND4 -7514
MT-CO1 -7200
FASTKD2 -6872
MT-ND5 -6746
MT-ATP8 -5196
FASTK -3799
FASTKD5 -2927
MT-ND6 634

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MT-ND2 -10254
MT-ND3 -10178
MT-ND1 -10175
MT-CO2 -9586
MT-CO3 -9084
MT-ATP6 -8913
MT-ND4L -8461
MT-CYB -7734
TBRG4 -7522
MT-ND4 -7514
MT-CO1 -7200
FASTKD2 -6872
MT-ND5 -6746
MT-ATP8 -5196
FASTK -3799
FASTKD5 -2927
MT-ND6 634


Selenoamino acid metabolism
set Selenoamino acid metabolism
setSize 115
pANOVA 5.91e-40
s.dist -0.713
p.adjustANOVA 4.39e-38


Top enriched genes
Top 20 genes
GeneID Gene Rank
AHCY -10271
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
AIMP2 -10056
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AHCY -10271
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
AIMP2 -10056
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
NNMT -9722
RPS27 -9689
KARS1 -9654
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
PAPSS1 -9423
RPL41 -9414
RPL18A -9380
RPS11 -9342
DARS1 -9330
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
FAU -8964
EEF1E1 -8915
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
AIMP1 -8671
RPS17 -8642
RPL38 -8565
EEFSEC -8494
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
GSR -8211
RPL37 -8133
RPS14 -8102
RARS1 -7900
RPS2 -7849
QARS1 -7691
RPL36 -7434
RPL28 -7372
RPL13 -7349
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
SARS1 -6943
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
EPRS1 -5843
PAPSS2 -5396
LARS1 -3519
SECISBP2 -1781
CBS -1772
HNMT -701
RPL9 -211
PSTK -117
RPL3L 556
SEPHS2 1631
TXNRD1 2133
SEPSECS 2236
IARS1 2871
MARS1 3601
INMT 6679
RPS26 7855
GNMT 8129
CTH 8316
SCLY 10451


Post-transcriptional silencing by small RNAs
set Post-transcriptional silencing by small RNAs
setSize 7
pANOVA 0.00111
s.dist 0.712
p.adjustANOVA 0.00526


Top enriched genes
Top 20 genes
GeneID Gene Rank
TNRC6C 11323
TNRC6B 10293
AGO1 10040
AGO4 8889
AGO2 7012
TNRC6A 6070
AGO3 4583

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All member genes
GeneID Gene Rank
TNRC6C 11323
TNRC6B 10293
AGO1 10040
AGO4 8889
AGO2 7012
TNRC6A 6070
AGO3 4583


Cristae formation
set Cristae formation
setSize 33
pANOVA 2.45e-12
s.dist -0.704
p.adjustANOVA 5.14e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP5MK -10379
ATP5MG -10104
ATP5F1C -10016
ATP5F1E -10001
ATP5MC1 -9956
ATP5PO -9870
CHCHD3 -9780
ATP5PB -9734
ATP5PD -9683
ATP5PF -9667
ATP5F1A -9448
ATP5F1B -9412
TMEM11 -9361
ATP5MC2 -9310
MT-ATP6 -8913
MICOS10 -8875
ATP5MF -8778
ATP5MJ -8412
MICOS13 -8126
ATP5MC3 -8105

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MK -10379
ATP5MG -10104
ATP5F1C -10016
ATP5F1E -10001
ATP5MC1 -9956
ATP5PO -9870
CHCHD3 -9780
ATP5PB -9734
ATP5PD -9683
ATP5PF -9667
ATP5F1A -9448
ATP5F1B -9412
TMEM11 -9361
ATP5MC2 -9310
MT-ATP6 -8913
MICOS10 -8875
ATP5MF -8778
ATP5MJ -8412
MICOS13 -8126
ATP5MC3 -8105
DMAC2L -8047
ATP5F1D -7279
IMMT -7116
HSPA9 -5918
ATP5ME -5433
MT-ATP8 -5196
DNAJC11 -5157
MTX2 -4777
SAMM50 -3338
CHCHD6 -3256
APOOL -2016
APOO 914
MTX1 5340


Mitochondrial calcium ion transport
set Mitochondrial calcium ion transport
setSize 22
pANOVA 1.31e-08
s.dist -0.7
p.adjustANOVA 1.49e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
VDAC3 -10366
SLC8A3 -10256
AFG3L2 -10172
VDAC1 -9998
PHB -9742
AKAP1 -9602
VDAC2 -9592
STOML2 -9551
MCUB -9441
PHB2 -9438
PARL -8417
PMPCB -7760
MICU3 -7477
MCU -7153
MICU1 -6622
SMDT1 -6382
PMPCA -5260
MICU2 -4703
LETM1 -4666
YME1L1 -3663

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VDAC3 -10366
SLC8A3 -10256
AFG3L2 -10172
VDAC1 -9998
PHB -9742
AKAP1 -9602
VDAC2 -9592
STOML2 -9551
MCUB -9441
PHB2 -9438
PARL -8417
PMPCB -7760
MICU3 -7477
MCU -7153
MICU1 -6622
SMDT1 -6382
PMPCA -5260
MICU2 -4703
LETM1 -4666
YME1L1 -3663
SLC8B1 857
SPG7 928


Packaging Of Telomere Ends
set Packaging Of Telomere Ends
setSize 18
pANOVA 2.9e-07
s.dist -0.698
p.adjustANOVA 2.68e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC6 -10474
H2BC21 -10432
H2BC11 -10259
H2BC12 -10074
H2BC4 -9769
H2AJ -9643
H2BC5 -9558
H2BC17 -9548
H2BC9 -9291
H2AC20 -9250
H2BC15 -8043
H2AZ2 -7005
ACD -4588
TINF2 -4188
TERF1 -4045
TERF2IP -1376
TERF2 -952
POT1 -871

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 -10474
H2BC21 -10432
H2BC11 -10259
H2BC12 -10074
H2BC4 -9769
H2AJ -9643
H2BC5 -9558
H2BC17 -9548
H2BC9 -9291
H2AC20 -9250
H2BC15 -8043
H2AZ2 -7005
ACD -4588
TINF2 -4188
TERF1 -4045
TERF2IP -1376
TERF2 -952
POT1 -871


SUMO is transferred from E1 to E2 (UBE2I, UBC9)
set SUMO is transferred from E1 to E2 (UBE2I, UBC9)
setSize 7
pANOVA 0.00143
s.dist -0.696
p.adjustANOVA 0.00644


Top enriched genes
Top 20 genes
GeneID Gene Rank
SAE1 -10054
SUMO2 -8085
SUMO3 -7807
UBA2 -7335
UBE2I -6568
SUMO1 -5166
RWDD3 -5146

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SAE1 -10054
SUMO2 -8085
SUMO3 -7807
UBA2 -7335
UBE2I -6568
SUMO1 -5166
RWDD3 -5146


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 3.99e-37
s.dist -0.689
p.adjustANOVA 2.41e-35


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
MAGOH -9018
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RNPS1 -8456
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
NCBP2 -7939
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
MAGOHB -7343
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
PPP2R1A -6960
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
PPP2CA -5309
PNRC2 -5013
UPF3A -4899
EIF4A3 -4774
RBM8A -4495
GSPT1 -2717
SMG9 -2457
ETF1 -2337
UPF3B -2308
UPF1 -2229
NCBP1 -1909
DCP1A -1863
SMG8 -1777
GSPT2 -1662
PPP2R2A -1500
RPL9 -211
RPL3L 556
EIF4G1 782
SMG5 3343
UPF2 4619
SMG1 7327
RPS26 7855
SMG6 8140
CASC3 8771
SMG7 10168


Nonsense-Mediated Decay (NMD)
set Nonsense-Mediated Decay (NMD)
setSize 114
pANOVA 3.99e-37
s.dist -0.689
p.adjustANOVA 2.41e-35


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
MAGOH -9018
FAU -8964
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
RPS27L -8745
RPS17 -8642
RPL38 -8565
RNPS1 -8456
RPL39L -8439
RPS5 -8386
RPS18 -8328
RPS12 -8238
RPL37 -8133
RPS14 -8102
NCBP2 -7939
RPS2 -7849
RPL36 -7434
RPL28 -7372
RPL13 -7349
MAGOHB -7343
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
PPP2R1A -6960
RPS21 -6829
RPS28 -6698
RPL36AL -6618
RPS16 -6448
PPP2CA -5309
PNRC2 -5013
UPF3A -4899
EIF4A3 -4774
RBM8A -4495
GSPT1 -2717
SMG9 -2457
ETF1 -2337
UPF3B -2308
UPF1 -2229
NCBP1 -1909
DCP1A -1863
SMG8 -1777
GSPT2 -1662
PPP2R2A -1500
RPL9 -211
RPL3L 556
EIF4G1 782
SMG5 3343
UPF2 4619
SMG1 7327
RPS26 7855
SMG6 8140
CASC3 8771
SMG7 10168


Beta oxidation of hexanoyl-CoA to butanoyl-CoA
set Beta oxidation of hexanoyl-CoA to butanoyl-CoA
setSize 5
pANOVA 0.00805
s.dist -0.684
p.adjustANOVA 0.0287


Top enriched genes
Top 20 genes
GeneID Gene Rank
ECHS1 -9129
ACADS -8639
HADHA -8241
HADH -4978
HADHB -4202

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ECHS1 -9129
ACADS -8639
HADHA -8241
HADH -4978
HADHB -4202


Mitochondrial RNA degradation
set Mitochondrial RNA degradation
setSize 25
pANOVA 3.17e-09
s.dist -0.684
p.adjustANOVA 4.06e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MT-ND2 -10254
MT-ND3 -10178
MT-ND1 -10175
SLIRP -9947
MT-CO2 -9586
GRSF1 -9525
MT-CO3 -9084
MT-ATP6 -8913
MT-ND4L -8461
MT-CYB -7734
TBRG4 -7522
MT-ND4 -7514
MT-CO1 -7200
FASTKD2 -6872
PNPT1 -6799
MT-ND5 -6746
LRPPRC -6120
MT-ATP8 -5196

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MT-ND2 -10254
MT-ND3 -10178
MT-ND1 -10175
SLIRP -9947
MT-CO2 -9586
GRSF1 -9525
MT-CO3 -9084
MT-ATP6 -8913
MT-ND4L -8461
MT-CYB -7734
TBRG4 -7522
MT-ND4 -7514
MT-CO1 -7200
FASTKD2 -6872
PNPT1 -6799
MT-ND5 -6746
LRPPRC -6120
MT-ATP8 -5196
SUPV3L1 -4502
FASTK -3799
FASTKD5 -2927
MT-ND6 634
REXO2 3732


rRNA processing in the mitochondrion
set rRNA processing in the mitochondrion
setSize 24
pANOVA 7.81e-09
s.dist -0.68
p.adjustANOVA 9.37e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MT-ND2 -10254
MT-ND3 -10178
MT-ND1 -10175
MRM2 -10098
MT-CO2 -9586
MT-CO3 -9084
MT-ATP6 -8913
MRM3 -8487
MT-ND4L -8461
HSD17B10 -7811
MT-CYB -7734
MT-ND4 -7514
MT-CO1 -7200
TRMT10C -7180
MT-ND5 -6746
MRM1 -6592
ELAC2 -6478
PRORP -6414

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
MT-ND2 -10254
MT-ND3 -10178
MT-ND1 -10175
MRM2 -10098
MT-CO2 -9586
MT-CO3 -9084
MT-ATP6 -8913
MRM3 -8487
MT-ND4L -8461
HSD17B10 -7811
MT-CYB -7734
MT-ND4 -7514
MT-CO1 -7200
TRMT10C -7180
MT-ND5 -6746
MRM1 -6592
ELAC2 -6478
PRORP -6414
MT-ATP8 -5196
NSUN4 -3181
TFB1M 2012
MTERF4 8548


Processing of SMDT1
set Processing of SMDT1
setSize 15
pANOVA 5.06e-06
s.dist -0.68
p.adjustANOVA 3.92e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
AFG3L2 -10172
PHB -9742
STOML2 -9551
MCUB -9441
PHB2 -9438
PARL -8417
PMPCB -7760
MICU3 -7477
MCU -7153
MICU1 -6622
SMDT1 -6382
PMPCA -5260
MICU2 -4703
YME1L1 -3663
SPG7 928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AFG3L2 -10172
PHB -9742
STOML2 -9551
MCUB -9441
PHB2 -9438
PARL -8417
PMPCB -7760
MICU3 -7477
MCU -7153
MICU1 -6622
SMDT1 -6382
PMPCA -5260
MICU2 -4703
YME1L1 -3663
SPG7 928


RNA Polymerase I Promoter Opening
set RNA Polymerase I Promoter Opening
setSize 17
pANOVA 1.39e-06
s.dist -0.676
p.adjustANOVA 1.16e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC6 -10474.0
H2BC21 -10432.0
H2BC11 -10259.0
H2BC12 -10074.0
H2BC4 -9769.0
H2AJ -9643.0
H2BC5 -9558.0
H2BC17 -9548.0
H2BC9 -9291.0
H2AC20 -9250.0
H2BC15 -8043.0
H3-3A -7626.0
H2AZ2 -7005.0
MBD2 -6464.0
MAPK3 -2453.0
H3C15 5172.5
UBTF 6712.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 -10474.0
H2BC21 -10432.0
H2BC11 -10259.0
H2BC12 -10074.0
H2BC4 -9769.0
H2AJ -9643.0
H2BC5 -9558.0
H2BC17 -9548.0
H2BC9 -9291.0
H2AC20 -9250.0
H2BC15 -8043.0
H3-3A -7626.0
H2AZ2 -7005.0
MBD2 -6464.0
MAPK3 -2453.0
H3C15 5172.5
UBTF 6712.0


Major pathway of rRNA processing in the nucleolus and cytosol
set Major pathway of rRNA processing in the nucleolus and cytosol
setSize 179
pANOVA 6.86e-55
s.dist -0.674
p.adjustANOVA 1.89e-52


Top enriched genes
Top 20 genes
GeneID Gene Rank
EXOSC2 -10342
UTP4 -10295
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
EXOSC1 -10014
RPS25 -10002
RPL6 -10000
UTP14A -9999
RPL21 -9992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC2 -10342
UTP4 -10295
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
EXOSC1 -10014
RPS25 -10002
RPL6 -10000
UTP14A -9999
RPL21 -9992
RPL14 -9979
UTP18 -9945
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
WDR46 -9884
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
EBNA1BP2 -9802
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
NOB1 -9539
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPP40 -9486
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
EXOSC5 -9386
RPL18A -9380
UTP11 -9362
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
EXOSC8 -9198
EXOSC7 -9171
RPS19 -9141
RPL23A -9123
WDR12 -9116
NOP56 -9093
RPS27A -9092
RRP36 -9065
UTP6 -8978
PES1 -8971
FAU -8964
RIOK1 -8946
GNL3 -8867
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
IMP3 -8762
RPS27L -8745
WDR43 -8713
SNU13 -8649
RPS17 -8642
FBL -8638
IMP4 -8588
RPL38 -8565
TSR1 -8552
DDX49 -8538
RPL39L -8439
RPS5 -8386
EMG1 -8381
RPS18 -8328
RPS12 -8238
RPL37 -8133
WDR75 -8119
RPS14 -8102
DDX47 -7881
RPP21 -7870
RPS2 -7849
RRP9 -7765
NOP14 -7663
RPL36 -7434
RPL28 -7372
RPL13 -7349
LTV1 -7337
MPHOSPH6 -7298
NOC4L -7263
EXOSC9 -7254
RPLP2 -7225
NOL12 -7217
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RRP7A -6939
XRN2 -6914
RPS21 -6829
DDX21 -6809
BMS1 -6773
PNO1 -6724
WDR18 -6703
RPS28 -6698
RPL36AL -6618
MPHOSPH10 -6571
NCL -6537
C1D -6483
DCAF13 -6475
RPS16 -6448
NOP58 -6436
NOL11 -6416
BOP1 -6261
TBL3 -6241
RIOK3 -6150
NOL6 -6078
RPP38 -5908
LAS1L -5660
RRP1 -5482
RPP25 -4963
NIP7 -4949
ISG20L2 -4936
UTP3 -4484
WDR3 -4088
RPP30 -3702
DHX37 -3594
WDR36 -3271
EXOSC3 -2758
EXOSC4 -2744
TEX10 -2663
SENP3 -2652
FCF1 -2309
FTSJ3 -2289
RBM28 -1955
UTP14C -1088
NOL9 -939
KRR1 -564
EXOSC6 -556
RPP14 -482
RCL1 -421
UTP15 -279
RPL9 -211
PDCD11 163
RIOK2 435
RPL3L 556
CSNK1E 759
ERI1 841
PWP2 1455
BYSL 1502
UTP25 1624
DIS3 2249
EXOSC10 3112
CSNK1D 3286
PELP1 3313
DDX52 3393
UTP20 4483
HEATR1 7471
RPS26 7855


rRNA processing
set rRNA processing
setSize 213
pANOVA 5.13e-64
s.dist -0.669
p.adjustANOVA 2.48e-61


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
EXOSC2 -10342
UTP4 -10295
MT-ND2 -10254
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
MT-ND3 -10178
MT-ND1 -10175
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
MRM2 -10098
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-RNR1 -10512
MT-RNR2 -10511
EXOSC2 -10342
UTP4 -10295
MT-ND2 -10254
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
MT-ND3 -10178
MT-ND1 -10175
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
MRM2 -10098
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
EXOSC1 -10014
RPS25 -10002
RPL6 -10000
UTP14A -9999
RPL21 -9992
RPL14 -9979
UTP18 -9945
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
WDR46 -9884
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
EBNA1BP2 -9802
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
MT-CO2 -9586
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
NOB1 -9539
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPP40 -9486
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
EXOSC5 -9386
RPL18A -9380
UTP11 -9362
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
TRMT112 -9205
EXOSC8 -9198
EXOSC7 -9171
RPS19 -9141
NHP2 -9131
RPL23A -9123
WDR12 -9116
NOP56 -9093
RPS27A -9092
MT-CO3 -9084
RRP36 -9065
UTP6 -8978
PES1 -8971
FAU -8964
RIOK1 -8946
MT-ATP6 -8913
GNL3 -8867
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
IMP3 -8762
RPS27L -8745
WDR43 -8713
SNU13 -8649
RPS17 -8642
FBL -8638
IMP4 -8588
RPL38 -8565
TSR1 -8552
DDX49 -8538
MRM3 -8487
MT-ND4L -8461
RPL39L -8439
RPS5 -8386
EMG1 -8381
RPS18 -8328
RPS12 -8238
RPL37 -8133
WDR75 -8119
RPS14 -8102
TSR3 -7953
DDX47 -7881
RPP21 -7870
RPS2 -7849
HSD17B10 -7811
RRP9 -7765
MT-CYB -7734
NOP14 -7663
MT-ND4 -7514
RPL36 -7434
RPL28 -7372
RPL13 -7349
LTV1 -7337
MPHOSPH6 -7298
NOC4L -7263
EXOSC9 -7254
RPLP2 -7225
NOL12 -7217
RPS29 -7204
MT-CO1 -7200
TRMT10C -7180
RPS4Y1 -7139
RPLP1 -7064
RRP7A -6939
XRN2 -6914
RPS21 -6829
DDX21 -6809
BMS1 -6773
DIMT1 -6759
MT-ND5 -6746
PNO1 -6724
WDR18 -6703
RPS28 -6698
RPL36AL -6618
MRM1 -6592
MPHOSPH10 -6571
NCL -6537
NOP10 -6490
C1D -6483
ELAC2 -6478
DCAF13 -6475
RPS16 -6448
NOP58 -6436
NOL11 -6416
PRORP -6414
BOP1 -6261
TBL3 -6241
RIOK3 -6150
NOL6 -6078
RPP38 -5908
LAS1L -5660
RRP1 -5482
MT-ATP8 -5196
DKC1 -5028
RPP25 -4963
NIP7 -4949
ISG20L2 -4936
UTP3 -4484
WDR3 -4088
RPP30 -3702
DHX37 -3594
NOP2 -3524
NAT10 -3474
WDR36 -3271
NSUN4 -3181
EXOSC3 -2758
EXOSC4 -2744
TEX10 -2663
SENP3 -2652
FCF1 -2309
FTSJ3 -2289
RBM28 -1955
UTP14C -1088
NOL9 -939
GAR1 -650
KRR1 -564
EXOSC6 -556
RPP14 -482
RCL1 -421
UTP15 -279
RPL9 -211
PDCD11 163
THUMPD1 233
RIOK2 435
RPL3L 556
CSNK1E 759
ERI1 841
PWP2 1455
BYSL 1502
UTP25 1624
TFB1M 2012
DIS3 2249
EXOSC10 3112
CSNK1D 3286
PELP1 3313
DDX52 3393
UTP20 4483
HEATR1 7471
RPS26 7855
MTERF4 8548


Regulation of expression of SLITs and ROBOs
set Regulation of expression of SLITs and ROBOs
setSize 149
pANOVA 3.07e-45
s.dist -0.668
p.adjustANOVA 3.96e-43


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBX1 -10486
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBX1 -10486
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
RPS25 -10002
RPL6 -10000
RPL21 -9992
RPL14 -9979
RPL10A -9943
RPS8 -9927
UBC -9921
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
RPL27 -9879
RPS15A -9863
PSMA6 -9852
RPL8 -9828
RPS6 -9824
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
PSMB1 -9651
PSMD8 -9644
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
PABPC1 -9587
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
RPL18A -9380
RPS11 -9342
RPL35 -9315
RPLP0 -9306
PSMB4 -9304
PSMA5 -9283
RPS10 -9273
RPL27A -9268
RPS19 -9141
RPL23A -9123
RPS27A -9092
MAGOH -9018
FAU -8964
PSMC3 -8850
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
PSMA2 -8771
PSMC2 -8761
RPS27L -8745
PSMB5 -8724
PSMC1 -8703
RPS17 -8642
RPL38 -8565
PSMB2 -8539
RNPS1 -8456
RPL39L -8439
RPS5 -8386
RPS18 -8328
PSMD7 -8322
PSMD13 -8295
PSMA7 -8269
RPS12 -8238
ELOC -8220
PSMB6 -8168
RPL37 -8133
RPS14 -8102
NCBP2 -7939
PSMB7 -7910
RPS2 -7849
PSMD14 -7790
PSMA1 -7755
RPL36 -7434
PSMC4 -7379
RPL28 -7372
RPL13 -7349
MAGOHB -7343
RPLP2 -7225
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
PSMC5 -6972
ELOB -6849
RPS21 -6829
PSMA4 -6763
PSMB3 -6723
RPS28 -6698
RPL36AL -6618
RPS16 -6448
ADRM1 -5642
UBB -5641
UPF3A -4899
PSMC6 -4862
EIF4A3 -4774
SEM1 -4690
RBM8A -4495
CUL2 -4044
PSMA3 -4017
PSMD3 -3863
PSMD2 -3070
GSPT1 -2717
ETF1 -2337
UPF3B -2308
NCBP1 -1909
DAG1 -1820
GSPT2 -1662
RPL9 -211
PSMD12 -126
RPL3L 556
EIF4G1 782
PSMD1 1165
USP33 2346
ROBO3 3129
LHX4 3304
PSMD11 3926
LDB1 4182
SLIT1 4335
UPF2 4619
COL4A5 5733
ROBO1 6242
PSMD6 6481
ZSWIM8 7132
RPS26 7855
CASC3 8771


Complex I biogenesis
set Complex I biogenesis
setSize 66
pANOVA 5.8e-21
s.dist -0.668
p.adjustANOVA 2.33e-19


Top enriched genes
Top 20 genes
GeneID Gene Rank
NDUFA6 -10398.0
MT-ND2 -10254.0
MT-ND3 -10178.0
MT-ND1 -10175.0
NDUFAF3 -10105.0
NDUFS4 -10099.0
HSCB -10019.0
NDUFB9 -9619.0
ECSIT -9573.0
NDUFA12 -9503.0
PYURF -9373.5
NDUFA10 -9279.0
TIMMDC1 -9243.0
NDUFC2 -9177.0
NDUFB11 -9107.0
NDUFAB1 -9089.0
NDUFV2 -9068.0
OXA1L -8897.0
NDUFB2 -8889.0
NDUFB5 -8864.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA6 -10398.0
MT-ND2 -10254.0
MT-ND3 -10178.0
MT-ND1 -10175.0
NDUFAF3 -10105.0
NDUFS4 -10099.0
HSCB -10019.0
NDUFB9 -9619.0
ECSIT -9573.0
NDUFA12 -9503.0
PYURF -9373.5
NDUFA10 -9279.0
TIMMDC1 -9243.0
NDUFC2 -9177.0
NDUFB11 -9107.0
NDUFAB1 -9089.0
NDUFV2 -9068.0
OXA1L -8897.0
NDUFB2 -8889.0
NDUFB5 -8864.0
NDUFA1 -8823.0
NDUFB4 -8746.0
NDUFB1 -8736.0
NDUFA8 -8604.0
NDUFB7 -8566.0
TMEM126A -8517.0
NDUFB6 -8497.0
NDUFA3 -8348.0
NDUFC1 -8184.0
NDUFB8 -7761.0
LYRM2 -7722.0
NDUFAF8 -7677.0
NDUFS5 -7646.0
NDUFA2 -7560.0
MT-ND4 -7514.0
NDUFB10 -7420.0
TMEM126B -7390.0
NDUFS3 -7275.0
NDUFA13 -7048.0
NDUFS8 -7023.0
NDUFS6 -6915.0
NDUFAF4 -6900.0
MT-ND5 -6746.0
NDUFA5 -6499.0
TMEM186 -6438.0
NDUFB3 -6424.0
NDUFV1 -6009.0
HSPA9 -5918.0
NDUFS7 -5880.0
NDUFS2 -5784.0
NDUFAF5 -5755.0
NDUFA9 -5504.0
NDUFA7 -5405.0
NDUFAF2 -5404.0
ACAD9 -4674.0
NDUFV3 -4040.0
NDUFA11 -3442.0
COA1 -2148.0
SFXN4 -2058.0
NDUFAF6 -1828.0
NDUFS1 -1665.0
NDUFAF7 -1124.0
FOXRED1 426.0
MT-ND6 634.0
NUBPL 1890.0
NDUFAF1 2264.0


rRNA processing in the nucleus and cytosol
set rRNA processing in the nucleus and cytosol
setSize 189
pANOVA 1.5e-56
s.dist -0.666
p.adjustANOVA 5.79e-54


Top enriched genes
Top 20 genes
GeneID Gene Rank
EXOSC2 -10342
UTP4 -10295
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
EXOSC1 -10014
RPS25 -10002
RPL6 -10000
UTP14A -9999
RPL21 -9992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EXOSC2 -10342
UTP4 -10295
RPS13 -10205
RPS7 -10199
RPL7 -10190
RPL35A -10181
RPL24 -10168
RPL22L1 -10141
RPL4 -10112
RPS3A -10095
RPL5 -10093
RPS4X -10091
RPL36A -10048
RPS20 -10024
RPL29 -10018
EXOSC1 -10014
RPS25 -10002
RPL6 -10000
UTP14A -9999
RPL21 -9992
RPL14 -9979
UTP18 -9945
RPL10A -9943
RPS8 -9927
RPS24 -9901
RPL7A -9895
RPL12 -9894
RPL15 -9885
WDR46 -9884
RPL27 -9879
RPS15A -9863
RPL8 -9828
RPS6 -9824
EBNA1BP2 -9802
RPL34 -9793
RPL23 -9781
RPL26 -9747
RPS23 -9736
RPS27 -9689
RPL32 -9631
RPL11 -9621
RPL22 -9606
RPL18 -9600
RPL19 -9594
RPL17 -9569
RPSA -9567
RPL30 -9555
RPS9 -9545
NOB1 -9539
RPL37A -9537
RPL10 -9522
RPS3 -9513
UBA52 -9492
RPP40 -9486
RPL13A -9485
RPL31 -9466
RPL39 -9434
RPL41 -9414
EXOSC5 -9386
RPL18A -9380
UTP11 -9362
RPS11 -9342
RPL35 -9315
RPLP0 -9306
RPS10 -9273
RPL27A -9268
TRMT112 -9205
EXOSC8 -9198
EXOSC7 -9171
RPS19 -9141
NHP2 -9131
RPL23A -9123
WDR12 -9116
NOP56 -9093
RPS27A -9092
RRP36 -9065
UTP6 -8978
PES1 -8971
FAU -8964
RIOK1 -8946
GNL3 -8867
RPL3 -8848
RPS15 -8795
RPL26L1 -8788
IMP3 -8762
RPS27L -8745
WDR43 -8713
SNU13 -8649
RPS17 -8642
FBL -8638
IMP4 -8588
RPL38 -8565
TSR1 -8552
DDX49 -8538
RPL39L -8439
RPS5 -8386
EMG1 -8381
RPS18 -8328
RPS12 -8238
RPL37 -8133
WDR75 -8119
RPS14 -8102
TSR3 -7953
DDX47 -7881
RPP21 -7870
RPS2 -7849
RRP9 -7765
NOP14 -7663
RPL36 -7434
RPL28 -7372
RPL13 -7349
LTV1 -7337
MPHOSPH6 -7298
NOC4L -7263
EXOSC9 -7254
RPLP2 -7225
NOL12 -7217
RPS29 -7204
RPS4Y1 -7139
RPLP1 -7064
RRP7A -6939
XRN2 -6914
RPS21 -6829
DDX21 -6809
BMS1 -6773
DIMT1 -6759
PNO1 -6724
WDR18 -6703
RPS28 -6698
RPL36AL -6618
MPHOSPH10 -6571
NCL -6537
NOP10 -6490
C1D -6483
DCAF13 -6475
RPS16 -6448
NOP58 -6436
NOL11 -6416
BOP1 -6261
TBL3 -6241
RIOK3 -6150
NOL6 -6078
RPP38 -5908
LAS1L -5660
RRP1 -5482
DKC1 -5028
RPP25 -4963
NIP7 -4949
ISG20L2 -4936
UTP3 -4484
WDR3 -4088
RPP30 -3702
DHX37 -3594
NOP2 -3524
NAT10 -3474
WDR36 -3271
EXOSC3 -2758
EXOSC4 -2744
TEX10 -2663
SENP3 -2652
FCF1 -2309
FTSJ3 -2289
RBM28 -1955
UTP14C -1088
NOL9 -939
GAR1 -650
KRR1 -564
EXOSC6 -556
RPP14 -482
RCL1 -421
UTP15 -279
RPL9 -211
PDCD11 163
THUMPD1 233
RIOK2 435
RPL3L 556
CSNK1E 759
ERI1 841
PWP2 1455
BYSL 1502
UTP25 1624
DIS3 2249
EXOSC10 3112
CSNK1D 3286
PELP1 3313
DDX52 3393
UTP20 4483
HEATR1 7471
RPS26 7855


Cleavage of the damaged purine
set Cleavage of the damaged purine
setSize 22
pANOVA 7.86e-08
s.dist -0.661
p.adjustANOVA 7.82e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC6 -10474
H2BC21 -10432
H2BC11 -10259
H2BC12 -10074
H2BC4 -9769
H2AJ -9643
H2BC5 -9558
H2BC17 -9548
MPG -9452
H2BC9 -9291
H2AC20 -9250
H2BC15 -8043
H2AZ2 -7005
ACD -4588
TINF2 -4188
TERF1 -4045
OGG1 -4027
MUTYH -3642
NEIL3 -2642
TERF2IP -1376

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 -10474
H2BC21 -10432
H2BC11 -10259
H2BC12 -10074
H2BC4 -9769
H2AJ -9643
H2BC5 -9558
H2BC17 -9548
MPG -9452
H2BC9 -9291
H2AC20 -9250
H2BC15 -8043
H2AZ2 -7005
ACD -4588
TINF2 -4188
TERF1 -4045
OGG1 -4027
MUTYH -3642
NEIL3 -2642
TERF2IP -1376
TERF2 -952
POT1 -871


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          rmarkdown_2.28          zlibbioc_1.50.0        
##   [7] vctrs_0.6.5             memoise_2.0.1.9000      base64enc_0.1-3        
##  [10] htmltools_0.5.8.1       S4Arrays_1.4.1          SparseArray_1.4.8      
##  [13] Formula_1.2-5           sass_0.4.9              KernSmooth_2.23-24     
##  [16] bslib_0.8.0             htmlwidgets_1.6.4       plyr_1.8.9             
##  [19] impute_1.78.0           cachem_1.1.0            mime_0.12              
##  [22] lifecycle_1.0.4         iterators_1.0.14        pkgconfig_2.0.3        
##  [25] Matrix_1.7-0            R6_2.5.1                fastmap_1.2.0          
##  [28] GenomeInfoDbData_1.2.12 shiny_1.9.1             digest_0.6.37          
##  [31] colorspace_2.1-1        AnnotationDbi_1.66.0    Hmisc_5.1-3            
##  [34] RSQLite_2.3.7           fansi_1.0.6             httr_1.4.7             
##  [37] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [40] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [43] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [46] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [49] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [52] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [55] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [58] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [61] preprocessCore_1.66.0   tidyr_1.3.1             data.table_1.16.0      
##  [64] xml2_1.3.6              utf8_1.2.4              XVector_0.44.0         
##  [67] foreach_1.5.2           pillar_1.9.0            stringr_1.5.1          
##  [70] later_1.3.2             rJava_1.0-11            splines_4.4.1          
##  [73] lattice_0.22-6          survival_3.7-0          bit_4.5.0              
##  [76] tidyselect_1.2.1        GO.db_3.19.1            locfit_1.5-9.10        
##  [79] Biostrings_2.72.1       knitr_1.48              gridExtra_2.3          
##  [82] svglite_2.1.3           xfun_0.48               stringi_1.8.4          
##  [85] UCSC.utils_1.0.0        yaml_2.3.10             xlsxjars_0.6.1         
##  [88] evaluate_1.0.1          codetools_0.2-20        cli_3.6.3              
##  [91] rpart_4.1.23            xtable_1.8-4            systemfonts_1.1.0      
##  [94] munsell_0.5.1           jquerylib_0.1.4         Rcpp_1.0.13            
##  [97] png_0.1-8               parallel_4.4.1          blob_1.2.4             
## [100] bitops_1.0-9            viridisLite_0.4.2       scales_1.3.0           
## [103] purrr_1.0.2             crayon_1.5.3            rlang_1.1.4            
## [106] KEGGREST_1.44.1

END of report