Mitch Report

date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	0.0480042
A1BG	-1.4395249
A1BG-AS1	-1.1273928
A1CF	0.5597110
A2M	1.6594386
A2M-AS1	1.0408279

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2725
num_genes_in_profile	21999
duplicated_genes_present	0
num_profile_genes_in_sets	8829
num_profile_genes_not_in_sets	13170

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1188
num_genesets_included	1537

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Peptide chain elongation	88	4.46e-43	-0.847	8.61e-41
Formation of a pool of free 40S subunits	100	2.30e-48	-0.844	8.91e-46
Eukaryotic Translation Elongation	93	1.50e-44	-0.838	3.63e-42
Viral mRNA Translation	88	1.48e-41	-0.831	2.38e-39
SARS-CoV-1 modulates host translation machinery	36	1.56e-17	-0.820	7.03e-16
Selenocysteine synthesis	92	4.42e-41	-0.808	6.57e-39
L13a-mediated translational silencing of Ceruloplasmin expression	110	4.86e-48	-0.802	1.34e-45
Cap-dependent Translation Initiation	118	3.28e-51	-0.800	2.12e-48
Eukaryotic Translation Initiation	118	3.28e-51	-0.800	2.12e-48
GTP hydrolysis and joining of the 60S ribosomal subunit	111	3.51e-48	-0.799	1.13e-45
Eukaryotic Translation Termination	92	1.01e-39	-0.794	1.40e-37
Formation of the ternary complex, and subsequently, the 43S complex	51	4.02e-22	-0.782	2.16e-20
Phosphate bond hydrolysis by NUDT proteins	7	3.96e-04	-0.773	3.27e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	6.17e-38	-0.767	7.01e-36
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	5.02e-39	-0.755	6.47e-37
SRP-dependent cotranslational protein targeting to membrane	111	6.56e-43	-0.753	1.15e-40
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.25e-22	-0.736	6.91e-21
Defective GALNT3 causes HFTC	9	1.38e-04	0.734	1.33e-03
Ribosomal scanning and start codon recognition	58	4.64e-22	-0.732	2.42e-20
Translation initiation complex formation	58	5.07e-22	-0.732	2.58e-20
Zygotic genome activation (ZGA)	5	4.85e-03	0.727	2.69e-02
Formation of ATP by chemiosmotic coupling	20	3.03e-08	-0.715	5.09e-07
Regulation of NFE2L2 gene expression	8	4.99e-04	0.711	3.95e-03
Mitochondrial translation initiation	90	2.71e-30	-0.697	1.81e-28
Selenoamino acid metabolism	115	3.88e-38	-0.696	4.69e-36
RUNX1 regulates transcription of genes involved in WNT signaling	5	7.27e-03	0.693	3.65e-02
SARS-CoV-2 modulates host translation machinery	49	6.84e-17	-0.689	2.94e-15
Reelin signalling pathway	5	8.24e-03	0.682	3.94e-02
Mitochondrial translation termination	90	4.06e-29	-0.682	2.53e-27
Mitochondrial translation elongation	90	5.70e-29	-0.680	3.44e-27
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	4.43e-04	0.676	3.57e-03
Processing of SMDT1	15	6.49e-06	-0.672	8.64e-05
Mitochondrial translation	96	4.69e-30	-0.672	3.02e-28
Signaling by RNF43 mutants	7	2.30e-03	0.665	1.48e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	2.12e-34	-0.662	2.05e-32
Nonsense-Mediated Decay (NMD)	114	2.12e-34	-0.662	2.05e-32
Regulation of expression of SLITs and ROBOs	149	4.07e-44	-0.660	8.73e-42
Formation of xylulose-5-phosphate	5	1.09e-02	-0.657	4.78e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	1.11e-02	-0.656	4.78e-02
Post-transcriptional silencing by small RNAs	7	2.71e-03	0.654	1.68e-02
Defective GALNT12 causes CRCS1	9	7.42e-04	0.649	5.60e-03
Vpu mediated degradation of CD4	39	2.59e-12	-0.647	9.10e-11
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	3.35e-03	0.640	2.00e-02
Recycling of eIF2:GDP	8	1.99e-03	-0.631	1.33e-02
Vif-mediated degradation of APOBEC3G	41	3.43e-12	-0.628	1.18e-10
Modulation by Mtb of host immune system	7	4.08e-03	-0.627	2.34e-02
Physiological factors	9	1.21e-03	0.623	8.65e-03
Translation	293	9.48e-75	-0.619	1.83e-71
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	2.24e-11	-0.619	6.55e-10
p53-Independent DNA Damage Response	39	2.24e-11	-0.619	6.55e-10

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Peptide chain elongation	88	4.46e-43	-0.847000	8.61e-41
Formation of a pool of free 40S subunits	100	2.30e-48	-0.844000	8.91e-46
Eukaryotic Translation Elongation	93	1.50e-44	-0.838000	3.63e-42
Viral mRNA Translation	88	1.48e-41	-0.831000	2.38e-39
SARS-CoV-1 modulates host translation machinery	36	1.56e-17	-0.820000	7.03e-16
Selenocysteine synthesis	92	4.42e-41	-0.808000	6.57e-39
L13a-mediated translational silencing of Ceruloplasmin expression	110	4.86e-48	-0.802000	1.34e-45
Cap-dependent Translation Initiation	118	3.28e-51	-0.800000	2.12e-48
Eukaryotic Translation Initiation	118	3.28e-51	-0.800000	2.12e-48
GTP hydrolysis and joining of the 60S ribosomal subunit	111	3.51e-48	-0.799000	1.13e-45
Eukaryotic Translation Termination	92	1.01e-39	-0.794000	1.40e-37
Formation of the ternary complex, and subsequently, the 43S complex	51	4.02e-22	-0.782000	2.16e-20
Phosphate bond hydrolysis by NUDT proteins	7	3.96e-04	-0.773000	3.27e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	6.17e-38	-0.767000	7.01e-36
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	5.02e-39	-0.755000	6.47e-37
SRP-dependent cotranslational protein targeting to membrane	111	6.56e-43	-0.753000	1.15e-40
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.25e-22	-0.736000	6.91e-21
Defective GALNT3 causes HFTC	9	1.38e-04	0.734000	1.33e-03
Ribosomal scanning and start codon recognition	58	4.64e-22	-0.732000	2.42e-20
Translation initiation complex formation	58	5.07e-22	-0.732000	2.58e-20
Zygotic genome activation (ZGA)	5	4.85e-03	0.727000	2.69e-02
Formation of ATP by chemiosmotic coupling	20	3.03e-08	-0.715000	5.09e-07
Regulation of NFE2L2 gene expression	8	4.99e-04	0.711000	3.95e-03
Mitochondrial translation initiation	90	2.71e-30	-0.697000	1.81e-28
Selenoamino acid metabolism	115	3.88e-38	-0.696000	4.69e-36
RUNX1 regulates transcription of genes involved in WNT signaling	5	7.27e-03	0.693000	3.65e-02
SARS-CoV-2 modulates host translation machinery	49	6.84e-17	-0.689000	2.94e-15
Reelin signalling pathway	5	8.24e-03	0.682000	3.94e-02
Mitochondrial translation termination	90	4.06e-29	-0.682000	2.53e-27
Mitochondrial translation elongation	90	5.70e-29	-0.680000	3.44e-27
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	4.43e-04	0.676000	3.57e-03
Processing of SMDT1	15	6.49e-06	-0.672000	8.64e-05
Mitochondrial translation	96	4.69e-30	-0.672000	3.02e-28
Signaling by RNF43 mutants	7	2.30e-03	0.665000	1.48e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	2.12e-34	-0.662000	2.05e-32
Nonsense-Mediated Decay (NMD)	114	2.12e-34	-0.662000	2.05e-32
Regulation of expression of SLITs and ROBOs	149	4.07e-44	-0.660000	8.73e-42
Formation of xylulose-5-phosphate	5	1.09e-02	-0.657000	4.78e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	1.11e-02	-0.656000	4.78e-02
Post-transcriptional silencing by small RNAs	7	2.71e-03	0.654000	1.68e-02
Defective GALNT12 causes CRCS1	9	7.42e-04	0.649000	5.60e-03
Vpu mediated degradation of CD4	39	2.59e-12	-0.647000	9.10e-11
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	3.35e-03	0.640000	2.00e-02
Recycling of eIF2:GDP	8	1.99e-03	-0.631000	1.33e-02
Vif-mediated degradation of APOBEC3G	41	3.43e-12	-0.628000	1.18e-10
Modulation by Mtb of host immune system	7	4.08e-03	-0.627000	2.34e-02
Physiological factors	9	1.21e-03	0.623000	8.65e-03
Translation	293	9.48e-75	-0.619000	1.83e-71
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	2.24e-11	-0.619000	6.55e-10
p53-Independent DNA Damage Response	39	2.24e-11	-0.619000	6.55e-10
p53-Independent G1/S DNA damage checkpoint	39	2.24e-11	-0.619000	6.55e-10
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	1.52e-10	-0.608000	3.59e-09
Complex III assembly	23	6.22e-07	-0.600000	9.53e-06
Phenylalanine metabolism	5	2.07e-02	-0.598000	7.36e-02
Negative regulation of NOTCH4 signaling	44	6.87e-12	-0.597000	2.23e-10
Complex I biogenesis	66	6.23e-17	-0.595000	2.73e-15
Ubiquitin-dependent degradation of Cyclin D	39	1.38e-10	-0.594000	3.34e-09
Calcitonin-like ligand receptors	5	2.19e-02	0.592000	7.66e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	5.39e-11	-0.592000	1.47e-09
Adenylate cyclase activating pathway	8	3.75e-03	0.592000	2.17e-02
Role of ABL in ROBO-SLIT signaling	6	1.23e-02	0.590000	5.23e-02
Proteasome assembly	50	5.55e-13	-0.589000	2.19e-11
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	1.34e-02	-0.583000	5.60e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	6.63e-11	-0.582000	1.75e-09
Mitochondrial calcium ion transport	22	2.57e-06	-0.579000	3.68e-05
Influenza Viral RNA Transcription and Replication	135	5.47e-31	-0.576000	3.77e-29
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	2.58e-02	-0.576000	8.63e-02
Regulation of Apoptosis	40	3.01e-10	-0.575000	6.85e-09
Autodegradation of the E3 ubiquitin ligase COP1	38	8.38e-10	-0.575000	1.80e-08
Cellular response to starvation	148	3.28e-33	-0.571000	2.88e-31
Acetylcholine binding and downstream events	5	2.71e-02	0.571000	8.89e-02
Postsynaptic nicotinic acetylcholine receptors	5	2.71e-02	0.571000	8.89e-02
Synthesis of PIPs at the ER membrane	5	2.78e-02	0.568000	9.07e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	1.87e-10	-0.568000	4.29e-09
SCF(Skp2)-mediated degradation of p27/p21	50	4.47e-12	-0.566000	1.51e-10
Phenylalanine and tyrosine metabolism	9	3.31e-03	-0.565000	1.98e-02
LTC4-CYSLTR mediated IL4 production	5	2.86e-02	-0.565000	9.19e-02
NIK–>noncanonical NF-kB signaling	46	3.48e-11	-0.564000	9.76e-10
Cation-coupled Chloride cotransporters	6	1.69e-02	0.563000	6.33e-02
Cristae formation	33	2.21e-08	-0.563000	3.77e-07
rRNA modification in the mitochondrion	8	5.91e-03	-0.562000	3.12e-02
SCF-beta-TrCP mediated degradation of Emi1	42	3.44e-10	-0.560000	7.65e-09
Defective C1GALT1C1 causes TNPS	10	2.24e-03	0.558000	1.47e-02
Sulfide oxidation to sulfate	5	3.11e-02	-0.557000	9.84e-02
SLBP independent Processing of Histone Pre-mRNAs	10	2.46e-03	-0.553000	1.54e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.49e-03	-0.553000	1.03e-02
Autodegradation of Cdh1 by Cdh1:APC/C	54	2.18e-12	-0.552000	7.79e-11
Respiratory electron transport	149	2.34e-31	-0.552000	1.74e-29
Regulation of NPAS4 gene expression	11	1.58e-03	0.550000	1.08e-02
APC/C:Cdc20 mediated degradation of Securin	55	2.10e-12	-0.548000	7.65e-11
RUNX1 regulates transcription of genes involved in BCR signaling	6	2.02e-02	0.547000	7.26e-02
Proton-coupled monocarboxylate transport	6	2.12e-02	0.543000	7.48e-02
Hh mutants are degraded by ERAD	42	1.26e-09	-0.541000	2.64e-08
Regulation of ornithine decarboxylase (ODC)	38	8.92e-09	-0.539000	1.63e-07
HDMs demethylate histones	22	1.47e-05	0.534000	1.77e-04
Stabilization of p53	43	1.46e-09	-0.533000	3.03e-08
CDK-mediated phosphorylation and removal of Cdc6	60	1.08e-12	-0.531000	4.16e-11
Cross-presentation of soluble exogenous antigens (endosomes)	35	6.16e-08	-0.529000	1.01e-06
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	4.10e-02	-0.528000	1.20e-01
Sperm Motility And Taxes	6	2.54e-02	-0.527000	8.51e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	2.78e-04	-0.525000	2.45e-03
RUNX3 Regulates Immune Response and Cell Migration	6	2.61e-02	0.524000	8.68e-02
Folding of actin by CCT/TriC	10	4.10e-03	-0.524000	2.34e-02
RUNX1 regulates estrogen receptor mediated transcription	6	2.64e-02	0.523000	8.74e-02
SUMO is conjugated to E1 (UBA2:SAE1)	5	4.30e-02	-0.523000	1.25e-01
Dectin-1 mediated noncanonical NF-kB signaling	48	4.66e-10	-0.520000	1.02e-08
p53-Dependent G1 DNA Damage Response	52	9.42e-11	-0.519000	2.36e-09
p53-Dependent G1/S DNA damage checkpoint	52	9.42e-11	-0.519000	2.36e-09
RUNX1 regulates expression of components of tight junctions	5	4.45e-02	0.519000	1.28e-01
Release of apoptotic factors from the mitochondria	6	2.81e-02	-0.518000	9.11e-02
Hh mutants abrogate ligand secretion	43	4.65e-09	-0.516000	8.86e-08
Defective CFTR causes cystic fibrosis	47	1.00e-09	-0.515000	2.12e-08
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	1.46e-10	-0.514000	3.49e-09
Mitochondrial protein import	63	1.92e-12	-0.513000	7.12e-11
Mitochondrial iron-sulfur cluster biogenesis	13	1.38e-03	-0.512000	9.61e-03
Degradation of GLI2 by the proteasome	45	2.74e-09	-0.512000	5.41e-08
Degradation of AXIN	42	9.24e-09	-0.512000	1.67e-07
Influenza Infection	154	4.90e-28	-0.512000	2.87e-26
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	6.93e-12	-0.512000	2.23e-10
APOBEC3G mediated resistance to HIV-1 infection	5	4.85e-02	-0.509000	1.36e-01
Major pathway of rRNA processing in the nucleolus and cytosol	179	5.66e-32	-0.509000	4.37e-30
Erythrocytes take up oxygen and release carbon dioxide	7	1.97e-02	0.509000	7.12e-02
Cellular response to mitochondrial stress	9	8.27e-03	-0.508000	3.94e-02
Metabolism of polyamines	46	2.45e-09	-0.508000	4.88e-08
Degradation of DVL	43	8.13e-09	-0.508000	1.50e-07
Complex IV assembly	45	3.86e-09	-0.507000	7.54e-08
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	5.06e-02	0.505000	1.40e-01
G1/S DNA Damage Checkpoints	54	1.57e-10	-0.503000	3.65e-09
Nectin/Necl trans heterodimerization	5	5.16e-02	0.503000	1.42e-01
Regulation of RUNX3 expression and activity	45	5.99e-09	-0.501000	1.12e-07
GLI3 is processed to GLI3R by the proteasome	46	4.57e-09	-0.499000	8.84e-08
rRNA processing in the nucleus and cytosol	189	5.61e-32	-0.496000	4.37e-30
NFE2L2 regulating tumorigenic genes	11	4.54e-03	0.494000	2.56e-02
Abacavir ADME	5	5.61e-02	0.493000	1.51e-01
Degradation of GLI1 by the proteasome	46	7.16e-09	-0.493000	1.33e-07
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	3.43e-11	-0.490000	9.75e-10
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	2.20e-03	-0.490000	1.46e-02
Signaling by ROBO receptors	189	3.78e-31	-0.489000	2.71e-29
HDL assembly	6	3.85e-02	0.488000	1.15e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	63	2.79e-11	-0.485000	8.05e-10
CLEC7A (Dectin-1) induces NFAT activation	11	5.38e-03	0.485000	2.90e-02
rRNA processing	213	3.14e-34	-0.484000	2.89e-32
Maturation of TCA enzymes and regulation of TCA cycle	20	1.92e-04	-0.482000	1.75e-03
Regulation of CDH11 mRNA translation by microRNAs	8	1.84e-02	0.481000	6.71e-02
Regulation of NPAS4 mRNA translation	8	1.84e-02	0.481000	6.71e-02
Pexophagy	10	8.52e-03	-0.480000	4.02e-02
Androgen biosynthesis	5	6.29e-02	-0.480000	1.65e-01
Regulation of FOXO transcriptional activity by acetylation	10	8.74e-03	0.479000	4.11e-02
RORA activates gene expression	18	4.41e-04	0.478000	3.57e-03
Adenylate cyclase inhibitory pathway	11	6.22e-03	0.476000	3.21e-02
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	2.91e-02	-0.476000	9.29e-02
Hedgehog ligand biogenesis	47	1.74e-08	-0.475000	3.05e-07
Propionyl-CoA catabolism	5	6.60e-02	-0.475000	1.70e-01
Aerobic respiration and respiratory electron transport	245	1.56e-37	-0.474000	1.67e-35
Cohesin Loading onto Chromatin	10	9.69e-03	0.472000	4.40e-02
MECP2 regulates neuronal receptors and channels	14	2.26e-03	0.471000	1.48e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	7.55e-11	-0.470000	1.97e-09
Activation of Ca-permeable Kainate Receptor	9	1.47e-02	0.469000	5.87e-02
Ionotropic activity of kainate receptors	9	1.47e-02	0.469000	5.87e-02
Regulation of RUNX1 Expression and Activity	18	5.87e-04	0.468000	4.55e-03
InlA-mediated entry of Listeria monocytogenes into host cells	9	1.58e-02	-0.465000	6.11e-02
Anchoring fibril formation	10	1.11e-02	0.464000	4.78e-02
Regulation of APC/C activators between G1/S and early anaphase	68	4.21e-11	-0.462000	1.16e-09
tRNA modification in the mitochondrion	9	1.64e-02	-0.462000	6.24e-02
Type I hemidesmosome assembly	8	2.39e-02	0.461000	8.23e-02
Neurofascin interactions	5	7.72e-02	0.456000	1.89e-01
RUNX3 regulates p14-ARF	10	1.25e-02	0.456000	5.28e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	7.11e-10	-0.456000	1.54e-08
Interleukin-7 signaling	21	3.13e-04	0.454000	2.70e-03
Methionine salvage pathway	6	5.41e-02	-0.454000	1.47e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	59	1.66e-09	-0.454000	3.41e-08
Chondroitin sulfate biosynthesis	12	6.57e-03	0.453000	3.38e-02
TGFBR3 expression	20	4.68e-04	0.452000	3.74e-03
Arachidonate production from DAG	5	8.17e-02	-0.450000	1.96e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	7.14e-03	-0.448000	3.61e-02
Orc1 removal from chromatin	58	4.68e-09	-0.445000	8.86e-08
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	8.58e-02	0.444000	2.04e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.24e-04	-0.443000	1.22e-03
Translesion synthesis by POLI	17	1.55e-03	-0.443000	1.06e-02
Activated NTRK3 signals through PI3K	5	8.61e-02	0.443000	2.04e-01
Somitogenesis	41	9.18e-07	-0.443000	1.39e-05
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	3.38e-04	-0.441000	2.87e-03
PKA activation	15	3.17e-03	0.440000	1.92e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	6.31e-02	0.438000	1.65e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	1.58e-04	-0.437000	1.48e-03
Citric acid cycle (TCA cycle)	34	1.08e-05	-0.436000	1.35e-04
Interleukin-18 signaling	6	6.45e-02	0.436000	1.67e-01
Termination of O-glycan biosynthesis	16	2.55e-03	0.436000	1.58e-02
Activation of PUMA and translocation to mitochondria	9	2.37e-02	0.436000	8.18e-02
FLT3 signaling by CBL mutants	7	4.70e-02	-0.434000	1.34e-01
Sodium/Proton exchangers	7	4.84e-02	0.431000	1.36e-01
RUNX2 regulates genes involved in cell migration	6	6.77e-02	0.431000	1.73e-01
Coenzyme A biosynthesis	7	4.85e-02	-0.431000	1.36e-01
TNFR1-mediated ceramide production	6	6.79e-02	-0.430000	1.73e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	4.90e-02	0.430000	1.37e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	8.53e-05	-0.429000	8.67e-04
Translesion synthesis by REV1	16	2.98e-03	-0.429000	1.82e-02
Nephrin family interactions	20	9.64e-04	0.426000	7.06e-03
Activation of NF-kappaB in B cells	54	6.14e-08	-0.426000	1.01e-06
Cellular response to hypoxia	59	1.76e-08	-0.424000	3.07e-07
mRNA Splicing - Minor Pathway	50	2.20e-07	-0.423000	3.49e-06
Switching of origins to a post-replicative state	79	9.05e-11	-0.422000	2.33e-09
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.57e-02	0.421000	6.11e-02
SARS-CoV-1-host interactions	95	1.48e-12	-0.420000	5.61e-11
PINK1-PRKN Mediated Mitophagy	31	5.34e-05	-0.419000	5.76e-04
Pregnenolone biosynthesis	10	2.19e-02	-0.419000	7.66e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.06e-01	-0.417000	2.37e-01
ABC transporter disorders	60	2.82e-08	-0.414000	4.77e-07
Signaling by WNT in cancer	30	8.79e-05	0.414000	8.89e-04
Lipophagy	7	5.82e-02	-0.413000	1.56e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	2.41e-02	-0.412000	8.24e-02
Mitotic Telophase/Cytokinesis	13	1.02e-02	0.411000	4.56e-02
RUNX3 regulates BCL2L11 (BIM) transcription	5	1.11e-01	0.411000	2.46e-01
NFE2L2 regulates pentose phosphate pathway genes	8	4.40e-02	0.411000	1.27e-01
Specification of primordial germ cells	6	8.21e-02	0.410000	1.97e-01
Signaling by LTK	10	2.50e-02	0.409000	8.45e-02
Role of second messengers in netrin-1 signaling	6	8.25e-02	0.409000	1.98e-01
Aflatoxin activation and detoxification	14	8.02e-03	-0.409000	3.86e-02
Translesion synthesis by POLK	17	3.61e-03	-0.408000	2.11e-02
PCNA-Dependent Long Patch Base Excision Repair	21	1.23e-03	-0.407000	8.73e-03
Regulation of RUNX2 expression and activity	54	2.43e-07	-0.406000	3.81e-06
Defensins	8	4.79e-02	0.404000	1.35e-01
Signal attenuation	9	3.61e-02	0.404000	1.09e-01
Mitochondrial Fatty Acid Beta-Oxidation	36	2.88e-05	-0.403000	3.27e-04
Tryptophan catabolism	12	1.57e-02	-0.403000	6.11e-02
Mitochondrial protein degradation	96	1.04e-11	-0.401000	3.28e-10
APC truncation mutants have impaired AXIN binding	14	9.34e-03	0.401000	4.28e-02
AXIN missense mutants destabilize the destruction complex	14	9.34e-03	0.401000	4.28e-02
Signaling by AMER1 mutants	14	9.34e-03	0.401000	4.28e-02
Signaling by APC mutants	14	9.34e-03	0.401000	4.28e-02
Signaling by AXIN mutants	14	9.34e-03	0.401000	4.28e-02
Truncations of AMER1 destabilize the destruction complex	14	9.34e-03	0.401000	4.28e-02
Aryl hydrocarbon receptor signalling	6	8.93e-02	-0.401000	2.10e-01
Regulation of IFNA/IFNB signaling	12	1.63e-02	0.401000	6.21e-02
Assembly of the pre-replicative complex	87	1.13e-10	-0.400000	2.80e-09
Purine salvage	12	1.65e-02	-0.400000	6.24e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	39	1.57e-05	0.400000	1.89e-04
APC/C-mediated degradation of cell cycle proteins	75	2.19e-09	-0.399000	4.40e-08
Regulation of mitotic cell cycle	75	2.19e-09	-0.399000	4.40e-08
Prostanoid ligand receptors	8	5.05e-02	0.399000	1.40e-01
Protein methylation	15	7.71e-03	-0.397000	3.77e-02
EGFR interacts with phospholipase C-gamma	7	6.92e-02	0.397000	1.75e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.32e-02	-0.395000	8.05e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	7.03e-02	0.395000	1.77e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	8.17e-04	-0.395000	6.05e-03
Synthesis of diphthamide-EEF2	8	5.37e-02	-0.394000	1.46e-01
Displacement of DNA glycosylase by APEX1	9	4.11e-02	-0.393000	1.20e-01
Dual Incision in GG-NER	41	1.34e-05	-0.393000	1.64e-04
Metabolism of amino acids and derivatives	308	2.27e-32	-0.392000	1.90e-30
FBXW7 Mutants and NOTCH1 in Cancer	5	1.30e-01	-0.391000	2.77e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	1.30e-01	-0.391000	2.77e-01
FGFR1b ligand binding and activation	5	1.31e-01	0.390000	2.78e-01
Termination of translesion DNA synthesis	32	1.35e-04	-0.390000	1.31e-03
Glutathione conjugation	28	3.63e-04	-0.389000	3.02e-03
Alternative complement activation	5	1.32e-01	-0.389000	2.79e-01
SHC-related events triggered by IGF1R	8	5.70e-02	0.389000	1.53e-01
ROBO receptors bind AKAP5	7	7.54e-02	0.388000	1.87e-01
Fructose metabolism	7	7.56e-02	-0.388000	1.87e-01
Asymmetric localization of PCP proteins	49	2.65e-06	-0.388000	3.76e-05
FGFR2b ligand binding and activation	6	1.00e-01	0.387000	2.29e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.63e-02	0.387000	8.73e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	2.65e-02	0.386000	8.75e-02
Fibronectin matrix formation	6	1.01e-01	0.386000	2.30e-01
rRNA processing in the mitochondrion	24	1.06e-03	-0.386000	7.69e-03
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	2.69e-02	-0.385000	8.85e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	7.67e-03	-0.385000	3.77e-02
IGF1R signaling cascade	38	4.11e-05	0.384000	4.61e-04
Formation of tubulin folding intermediates by CCT/TriC	21	2.29e-03	-0.384000	1.48e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	1.04e-01	0.384000	2.35e-01
ChREBP activates metabolic gene expression	7	7.92e-02	0.383000	1.93e-01
mRNA Splicing	211	9.11e-22	-0.382000	4.51e-20
RNA Polymerase I Transcription Termination	30	2.87e-04	-0.382000	2.51e-03
ER-Phagosome pathway	75	1.02e-08	-0.382000	1.80e-07
Inhibition of Signaling by Overexpressed EGFR	6	1.06e-01	0.381000	2.37e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	6	1.06e-01	0.381000	2.37e-01
Vitamin C (ascorbate) metabolism	8	6.22e-02	0.381000	1.63e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	6	1.08e-01	0.379000	2.39e-01
Recognition of DNA damage by PCNA-containing replication complex	30	3.23e-04	-0.379000	2.77e-03
Downregulation of ERBB4 signaling	8	6.33e-02	-0.379000	1.65e-01
PKA-mediated phosphorylation of CREB	17	6.82e-03	0.379000	3.48e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	1.08e-01	-0.378000	2.41e-01
Synthesis of PIPs at the plasma membrane	52	2.68e-06	0.376000	3.78e-05
RNA Polymerase I Promoter Opening	17	7.30e-03	-0.376000	3.65e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	4.73e-04	0.375000	3.76e-03
RHO GTPases Activate Rhotekin and Rhophilins	8	6.65e-02	-0.375000	1.70e-01
RUNX3 regulates NOTCH signaling	14	1.59e-02	0.372000	6.11e-02
NRIF signals cell death from the nucleus	15	1.27e-02	-0.372000	5.34e-02
IRS-related events triggered by IGF1R	37	9.09e-05	0.372000	9.15e-04
Miscellaneous substrates	7	8.89e-02	0.371000	2.09e-01
Dectin-2 family	19	5.11e-03	0.371000	2.80e-02
PI3K Cascade	31	3.57e-04	0.370000	2.98e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	4.26e-02	0.370000	1.24e-01
N-Glycan antennae elongation	13	2.09e-02	0.370000	7.38e-02
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	5.25e-03	-0.370000	2.84e-02
mRNA Splicing - Major Pathway	203	1.06e-19	-0.369000	5.10e-18
Myogenesis	21	3.38e-03	0.369000	2.01e-02
Signaling by Leptin	10	4.39e-02	0.368000	1.27e-01
Purine catabolism	16	1.10e-02	-0.367000	4.78e-02
Interleukin-6 signaling	11	3.52e-02	0.367000	1.07e-01
Mitochondrial RNA degradation	25	1.52e-03	-0.366000	1.04e-02
Interconversion of nucleotide di- and triphosphates	27	1.02e-03	-0.365000	7.40e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	1.60e-07	-0.365000	2.60e-06
Integration of provirus	9	5.88e-02	-0.364000	1.57e-01
RNA Polymerase III Chain Elongation	18	7.54e-03	-0.364000	3.75e-02
Synthesis of DNA	108	6.48e-11	-0.364000	1.74e-09
Glycosphingolipid biosynthesis	15	1.48e-02	0.364000	5.88e-02
Apoptotic factor-mediated response	19	6.20e-03	-0.363000	3.21e-02
APC-Cdc20 mediated degradation of Nek2A	26	1.41e-03	-0.362000	9.76e-03
Ethanol oxidation	8	7.66e-02	-0.362000	1.89e-01
Processive synthesis on the lagging strand	15	1.56e-02	-0.361000	6.11e-02
Synthesis of PI	5	1.63e-01	0.360000	3.25e-01
Regulation of KIT signaling	15	1.58e-02	0.360000	6.11e-02
CTNNB1 S33 mutants aren’t phosphorylated	15	1.59e-02	0.360000	6.11e-02
CTNNB1 S37 mutants aren’t phosphorylated	15	1.59e-02	0.360000	6.11e-02
CTNNB1 S45 mutants aren’t phosphorylated	15	1.59e-02	0.360000	6.11e-02
CTNNB1 T41 mutants aren’t phosphorylated	15	1.59e-02	0.360000	6.11e-02
Signaling by CTNNB1 phospho-site mutants	15	1.59e-02	0.360000	6.11e-02
Signaling by GSK3beta mutants	15	1.59e-02	0.360000	6.11e-02
Fructose catabolism	5	1.64e-01	-0.359000	3.25e-01
PKA activation in glucagon signalling	14	2.02e-02	0.358000	7.26e-02
DNA Replication Pre-Initiation	103	3.44e-10	-0.358000	7.65e-09
MECP2 regulates transcription of neuronal ligands	5	1.67e-01	0.357000	3.30e-01
Protein localization	157	1.18e-14	-0.357000	4.84e-13
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	1.31e-01	0.356000	2.77e-01
Protein lipoylation	10	5.11e-02	-0.356000	1.41e-01
Malate-aspartate shuttle	8	8.11e-02	-0.356000	1.96e-01
Myoclonic epilepsy of Lafora	8	8.14e-02	-0.356000	1.96e-01
Mitophagy	38	1.47e-04	-0.356000	1.41e-03
2-LTR circle formation	7	1.05e-01	-0.354000	2.36e-01
Regulation of RAS by GAPs	55	5.77e-06	-0.353000	7.79e-05
Disorders of Developmental Biology	12	3.40e-02	0.353000	1.05e-01
Disorders of Nervous System Development	12	3.40e-02	0.353000	1.05e-01
Loss of function of MECP2 in Rett syndrome	12	3.40e-02	0.353000	1.05e-01
Pervasive developmental disorders	12	3.40e-02	0.353000	1.05e-01
MET activates PI3K/AKT signaling	5	1.73e-01	0.352000	3.38e-01
RNA Polymerase I Promoter Escape	45	4.43e-05	-0.352000	4.89e-04
Signaling by Erythropoietin	24	2.89e-03	0.351000	1.77e-02
O-glycosylation of TSR domain-containing proteins	28	1.30e-03	0.351000	9.14e-03
Synthesis of 12-eicosatetraenoic acid derivatives	6	1.37e-01	-0.351000	2.86e-01
Inhibition of DNA recombination at telomere	33	5.10e-04	-0.350000	4.01e-03
Prevention of phagosomal-lysosomal fusion	9	6.96e-02	-0.349000	1.76e-01
Regulation of innate immune responses to cytosolic DNA	14	2.44e-02	-0.347000	8.32e-02
Beta-catenin phosphorylation cascade	17	1.32e-02	0.347000	5.53e-02
Leading Strand Synthesis	14	2.51e-02	-0.346000	8.45e-02
Polymerase switching	14	2.51e-02	-0.346000	8.45e-02
SARS-CoV-2 modulates autophagy	11	4.71e-02	-0.346000	1.34e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	1.43e-01	0.345000	2.92e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	1.43e-01	0.345000	2.92e-01
Chaperone Mediated Autophagy	20	7.61e-03	-0.345000	3.76e-02
Diseases associated with O-glycosylation of proteins	50	2.50e-05	0.344000	2.86e-04
Creatine metabolism	6	1.44e-01	-0.344000	2.94e-01
Defective B3GALTL causes PpS	27	2.03e-03	0.343000	1.35e-02
Regulation of PTEN stability and activity	55	1.09e-05	-0.343000	1.35e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	1.16e-01	0.343000	2.54e-01
DNA Replication	128	2.12e-11	-0.343000	6.50e-10
Abortive elongation of HIV-1 transcript in the absence of Tat	23	4.49e-03	-0.342000	2.54e-02
Lagging Strand Synthesis	20	8.11e-03	-0.342000	3.89e-02
Endosomal/Vacuolar pathway	12	4.03e-02	-0.342000	1.19e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.86e-01	-0.342000	3.55e-01
Erythrocytes take up carbon dioxide and release oxygen	11	5.02e-02	0.341000	1.39e-01
O2/CO2 exchange in erythrocytes	11	5.02e-02	0.341000	1.39e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	7	1.19e-01	0.341000	2.59e-01
Prolactin receptor signaling	12	4.14e-02	-0.340000	1.21e-01
IRS-mediated signalling	35	5.03e-04	0.340000	3.97e-03
Nucleotide catabolism	28	1.93e-03	-0.339000	1.29e-02
NFE2L2 regulating MDR associated enzymes	8	9.75e-02	0.338000	2.24e-01
Insulin receptor signalling cascade	40	2.14e-04	0.338000	1.94e-03
Regulation of TP53 Activity through Association with Co-factors	13	3.49e-02	0.338000	1.07e-01
p130Cas linkage to MAPK signaling for integrins	11	5.25e-02	-0.338000	1.44e-01
Formation of the Early Elongation Complex	33	7.99e-04	-0.337000	5.98e-03
Formation of the HIV-1 Early Elongation Complex	33	7.99e-04	-0.337000	5.98e-03
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	1.23e-01	-0.337000	2.66e-01
Cytosolic tRNA aminoacylation	24	4.31e-03	-0.337000	2.45e-02
Synthesis, secretion, and deacylation of Ghrelin	11	5.33e-02	-0.337000	1.45e-01
Crosslinking of collagen fibrils	15	2.41e-02	0.336000	8.24e-02
Triglyceride biosynthesis	10	6.58e-02	0.336000	1.69e-01
Antimicrobial peptides	34	7.15e-04	0.335000	5.46e-03
Interleukin-2 signaling	11	5.53e-02	0.334000	1.50e-01
Antigen processing-Cross presentation	89	5.30e-08	-0.334000	8.83e-07
SIRT1 negatively regulates rRNA expression	22	6.97e-03	-0.332000	3.55e-02
O-linked glycosylation of mucins	47	8.10e-05	0.332000	8.28e-04
Trafficking and processing of endosomal TLR	13	3.90e-02	-0.331000	1.16e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	8.60e-02	-0.331000	2.04e-01
CTLA4 inhibitory signaling	21	8.77e-03	0.330000	4.11e-02
Removal of the Flap Intermediate	14	3.34e-02	-0.328000	1.03e-01
Formation of TC-NER Pre-Incision Complex	51	4.94e-05	-0.328000	5.39e-04
Signaling by NOTCH4	70	2.02e-06	-0.328000	2.95e-05
Nucleotide salvage	21	9.34e-03	-0.328000	4.28e-02
Ribavirin ADME	11	6.00e-02	-0.327000	1.59e-01
Synthesis of PIPs at the early endosome membrane	16	2.34e-02	0.327000	8.13e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	1.34e-01	0.327000	2.82e-01
Metalloprotease DUBs	20	1.14e-02	-0.327000	4.89e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	7.37e-02	-0.327000	1.84e-01
FCGR3A-mediated IL10 synthesis	99	2.03e-08	0.326000	3.51e-07
Packaging Of Telomere Ends	18	1.66e-02	-0.326000	6.26e-02
Early Phase of HIV Life Cycle	14	3.53e-02	-0.325000	1.07e-01
Regulation of BACH1 activity	11	6.22e-02	-0.325000	1.63e-01
Metabolism of RNA	718	6.33e-50	-0.325000	3.06e-47
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.00e-02	-0.325000	4.51e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.00e-02	-0.325000	4.51e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.03e-06	-0.324000	1.54e-05
Metabolism of cofactors	25	5.04e-03	-0.324000	2.76e-02
Activation of gene expression by SREBF (SREBP)	42	2.80e-04	0.324000	2.46e-03
Phosphorylation of Emi1	6	1.69e-01	0.324000	3.34e-01
Formation of Incision Complex in GG-NER	43	2.41e-04	-0.324000	2.16e-03
RUNX2 regulates bone development	26	4.34e-03	0.323000	2.47e-02
PTK6 Regulates Cell Cycle	6	1.71e-01	-0.323000	3.35e-01
Biosynthesis of Lipoxins (LX)	6	1.71e-01	0.323000	3.35e-01
Apoptosis induced DNA fragmentation	10	7.72e-02	-0.323000	1.89e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	5.24e-03	-0.323000	2.84e-02
Budding and maturation of HIV virion	26	4.71e-03	-0.320000	2.62e-02
Cytosolic iron-sulfur cluster assembly	13	4.62e-02	-0.319000	1.32e-01
Wax and plasmalogen biosynthesis	5	2.17e-01	-0.319000	3.93e-01
Post-chaperonin tubulin folding pathway	18	1.95e-02	-0.318000	7.10e-02
Platelet sensitization by LDL	16	2.79e-02	0.318000	9.07e-02
Regulation of localization of FOXO transcription factors	11	6.87e-02	0.317000	1.75e-01
SARS-CoV-1 Infection	138	1.28e-10	-0.317000	3.12e-09
Establishment of Sister Chromatid Cohesion	11	6.90e-02	0.317000	1.75e-01
Suppression of phagosomal maturation	12	5.82e-02	-0.316000	1.56e-01
PI3K/AKT activation	8	1.22e-01	0.316000	2.64e-01
Interleukin receptor SHC signaling	23	8.89e-03	0.315000	4.15e-02
Regulation of signaling by NODAL	6	1.82e-01	0.315000	3.50e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.51e-19	-0.314000	7.12e-18
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	2.11e-02	0.314000	7.45e-02
Metabolism of nucleotides	85	5.94e-07	-0.313000	9.26e-06
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	1.10e-02	0.313000	4.78e-02
Dermatan sulfate biosynthesis	6	1.84e-01	0.313000	3.53e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	3.06e-02	0.312000	9.70e-02
PI5P Regulates TP53 Acetylation	8	1.27e-01	0.312000	2.73e-01
mRNA Capping	29	3.71e-03	-0.311000	2.16e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.60e-02	-0.311000	6.12e-02
Synthesis of PIPs at the Golgi membrane	16	3.15e-02	0.311000	9.92e-02
Activated NTRK3 signals through RAS	7	1.56e-01	0.310000	3.12e-01
Phosphorylation of the APC/C	20	1.65e-02	-0.310000	6.24e-02
Transcriptional Regulation by MECP2	49	1.75e-04	0.310000	1.63e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	4.54e-02	-0.309000	1.30e-01
Cyclin E associated events during G1/S transition	73	5.61e-06	-0.307000	7.64e-05
Sealing of the nuclear envelope (NE) by ESCRT-III	24	9.56e-03	-0.306000	4.37e-02
O-linked glycosylation	85	1.13e-06	0.305000	1.68e-05
Transcriptional regulation of pluripotent stem cells	21	1.56e-02	0.305000	6.11e-02
Nef and signal transduction	8	1.36e-01	0.305000	2.85e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	6.19e-03	-0.304000	3.21e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	6.19e-03	-0.304000	3.21e-02
RHOD GTPase cycle	50	2.00e-04	0.304000	1.82e-03
BBSome-mediated cargo-targeting to cilium	22	1.37e-02	-0.304000	5.64e-02
Cleavage of the damaged purine	22	1.40e-02	-0.303000	5.64e-02
Depurination	22	1.40e-02	-0.303000	5.64e-02
Recognition and association of DNA glycosylase with site containing an affected purine	22	1.40e-02	-0.303000	5.64e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	5.04e-02	0.302000	1.39e-01
Signaling by BMP	23	1.23e-02	0.302000	5.22e-02
FCGR activation	76	5.46e-06	0.302000	7.48e-05
Response to metal ions	6	2.01e-01	-0.301000	3.75e-01
Resolution of Abasic Sites (AP sites)	38	1.34e-03	-0.301000	9.36e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	1.35e-03	-0.300000	9.41e-03
Incretin synthesis, secretion, and inactivation	14	5.18e-02	-0.300000	1.42e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	5.18e-02	-0.300000	1.42e-01
Telomere Maintenance	78	4.69e-06	-0.300000	6.48e-05
NOTCH3 Intracellular Domain Regulates Transcription	22	1.50e-02	0.300000	5.94e-02
Erythropoietin activates Phospholipase C gamma (PLCG)	6	2.04e-01	0.300000	3.78e-01
MECP2 regulates transcription factors	5	2.47e-01	0.299000	4.32e-01
CD163 mediating an anti-inflammatory response	9	1.21e-01	0.299000	2.62e-01
TNFR2 non-canonical NF-kB pathway	84	2.30e-06	-0.298000	3.34e-05
Alpha-oxidation of phytanate	6	2.06e-01	-0.298000	3.81e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	7.23e-06	-0.298000	9.50e-05
Interleukin-37 signaling	19	2.48e-02	0.297000	8.41e-02
Synaptic adhesion-like molecules	17	3.38e-02	0.297000	1.05e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	1.37e-04	0.297000	1.32e-03
Global Genome Nucleotide Excision Repair (GG-NER)	84	2.49e-06	-0.297000	3.59e-05
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	4.67e-02	0.297000	1.33e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	2.09e-01	-0.296000	3.83e-01
Josephin domain DUBs	10	1.05e-01	-0.296000	2.36e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	7.65e-02	0.295000	1.89e-01
Cyclin A:Cdk2-associated events at S phase entry	75	9.91e-06	-0.295000	1.25e-04
SHC1 events in EGFR signaling	12	7.70e-02	0.295000	1.89e-01
Regulation of MECP2 expression and activity	29	6.02e-03	0.295000	3.14e-02
Downstream signaling of activated FGFR1	22	1.68e-02	0.295000	6.30e-02
Signaling by FGFR4 in disease	11	9.10e-02	0.294000	2.13e-01
Late endosomal microautophagy	30	5.39e-03	-0.293000	2.90e-02
Protein hydroxylation	17	3.62e-02	-0.293000	1.09e-01
Calcineurin activates NFAT	9	1.27e-01	0.293000	2.73e-01
ALK mutants bind TKIs	11	9.21e-02	0.293000	2.15e-01
N-glycan antennae elongation in the medial/trans-Golgi	21	2.01e-02	0.293000	7.23e-02
Negative regulators of DDX58/IFIH1 signaling	34	3.11e-03	-0.293000	1.89e-02
Dual incision in TC-NER	63	5.76e-05	-0.293000	6.05e-04
MET activates RAS signaling	10	1.09e-01	0.293000	2.41e-01
Activation of RAS in B cells	5	2.57e-01	0.293000	4.42e-01
Role of LAT2/NTAL/LAB on calcium mobilization	77	9.14e-06	0.292000	1.16e-04
GAB1 signalosome	15	5.00e-02	0.292000	1.39e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	7.08e-05	-0.292000	7.32e-04
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	5.93e-02	0.291000	1.57e-01
Regulation of PTEN mRNA translation	13	6.94e-02	0.291000	1.76e-01
SARS-CoV-1 activates/modulates innate immune responses	40	1.47e-03	-0.291000	1.01e-02
Paracetamol ADME	19	2.85e-02	-0.290000	9.18e-02
Phase 4 - resting membrane potential	9	1.32e-01	0.290000	2.79e-01
Assembly of the ORC complex at the origin of replication	23	1.64e-02	-0.289000	6.24e-02
Base Excision Repair	57	1.64e-04	-0.289000	1.53e-03
Drug-mediated inhibition of CDK4/CDK6 activity	5	2.64e-01	0.288000	4.51e-01
Sodium-coupled phosphate cotransporters	5	2.65e-01	0.288000	4.51e-01
RNA Polymerase II Transcription Termination	66	5.55e-05	-0.287000	5.89e-04
Uptake and function of anthrax toxins	11	9.96e-02	0.287000	2.28e-01
FOXO-mediated transcription of cell death genes	16	4.75e-02	0.286000	1.34e-01
PDH complex synthesizes acetyl-CoA from PYR	5	2.69e-01	-0.286000	4.56e-01
PCP/CE pathway	75	1.90e-05	-0.286000	2.24e-04
Role of phospholipids in phagocytosis	88	3.82e-06	0.285000	5.31e-05
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	1.39e-01	-0.285000	2.88e-01
CD22 mediated BCR regulation	58	1.79e-04	0.284000	1.65e-03
VLDLR internalisation and degradation	16	4.90e-02	-0.284000	1.37e-01
Transcriptional Regulation by NPAS4	27	1.10e-02	0.283000	4.78e-02
PI-3K cascade:FGFR1	13	7.78e-02	0.282000	1.90e-01
DNA Damage Bypass	47	8.12e-04	-0.282000	6.03e-03
Erythropoietin activates RAS	13	7.84e-02	0.282000	1.91e-01
Heme signaling	45	1.07e-03	0.282000	7.69e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	9.12e-02	-0.282000	2.13e-01
Signaling by FGFR2 IIIa TM	18	3.86e-02	-0.282000	1.15e-01
Defective pyroptosis	27	1.13e-02	-0.281000	4.88e-02
RNA Polymerase I Promoter Clearance	64	9.91e-05	-0.281000	9.81e-04
RNA Polymerase I Transcription	64	9.91e-05	-0.281000	9.81e-04
Activation of SMO	13	7.98e-02	0.281000	1.93e-01
Ubiquinol biosynthesis	13	8.04e-02	-0.280000	1.94e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	29	9.11e-03	-0.280000	4.24e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.04e-02	-0.280000	4.64e-02
Interaction between L1 and Ankyrins	26	1.39e-02	0.279000	5.64e-02
Downstream signaling events of B Cell Receptor (BCR)	68	7.41e-05	-0.278000	7.61e-04
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	7.21e-02	-0.278000	1.81e-01
PI Metabolism	79	2.10e-05	0.277000	2.44e-04
FLT3 signaling through SRC family kinases	6	2.41e-01	0.276000	4.24e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	8.51e-02	-0.276000	2.03e-01
Scavenging of heme from plasma	70	6.77e-05	0.275000	7.03e-04
Unwinding of DNA	12	9.91e-02	0.275000	2.27e-01
RNA Polymerase III Transcription Termination	23	2.26e-02	-0.275000	7.88e-02
Selective autophagy	77	3.10e-05	-0.275000	3.50e-04
RHOBTB1 GTPase cycle	23	2.29e-02	-0.274000	7.96e-02
Downstream signaling of activated FGFR2	20	3.39e-02	0.274000	1.05e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	1.34e-01	0.274000	2.82e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	83	1.59e-05	0.274000	1.90e-04
Metabolism of Angiotensinogen to Angiotensins	12	1.00e-01	0.274000	2.29e-01
Linoleic acid (LA) metabolism	7	2.10e-01	0.273000	3.85e-01
GDP-fucose biosynthesis	6	2.47e-01	-0.273000	4.32e-01
NFE2L2 regulating ER-stress associated genes	5	2.91e-01	0.273000	4.81e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	3.50e-02	-0.272000	1.07e-01
RET signaling	32	7.85e-03	0.272000	3.82e-02
Base-Excision Repair, AP Site Formation	29	1.14e-02	-0.271000	4.89e-02
Polymerase switching on the C-strand of the telomere	26	1.68e-02	-0.271000	6.32e-02
Organic cation transport	8	1.85e-01	0.271000	3.53e-01
Organic cation/anion/zwitterion transport	8	1.85e-01	0.271000	3.53e-01
NoRC negatively regulates rRNA expression	60	2.93e-04	-0.270000	2.55e-03
Azathioprine ADME	21	3.24e-02	-0.270000	1.01e-01
Suppression of apoptosis	7	2.17e-01	0.269000	3.93e-01
Negative regulation of the PI3K/AKT network	93	7.48e-06	0.269000	9.57e-05
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.43e-02	-0.267000	5.75e-02
TICAM1-dependent activation of IRF3/IRF7	13	9.53e-02	-0.267000	2.19e-01
RHOF GTPase cycle	39	3.91e-03	0.267000	2.25e-02
Other semaphorin interactions	16	6.49e-02	0.267000	1.68e-01
Signaling by ALK	24	2.39e-02	0.266000	8.23e-02
SOS-mediated signalling	7	2.23e-01	0.266000	4.02e-01
Host Interactions of HIV factors	118	6.02e-07	-0.266000	9.31e-06
RUNX2 regulates osteoblast differentiation	21	3.49e-02	0.266000	1.07e-01
Triglyceride metabolism	26	1.92e-02	0.265000	6.99e-02
Formation of paraxial mesoderm	52	9.87e-04	-0.264000	7.20e-03
IRAK1 recruits IKK complex	14	8.78e-02	-0.263000	2.07e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	8.78e-02	-0.263000	2.07e-01
Meiotic recombination	37	5.62e-03	-0.263000	3.00e-02
HIV Transcription Initiation	45	2.33e-03	-0.262000	1.48e-02
RNA Polymerase II HIV Promoter Escape	45	2.33e-03	-0.262000	1.48e-02
RNA Polymerase II Promoter Escape	45	2.33e-03	-0.262000	1.48e-02
RNA Polymerase II Transcription Initiation	45	2.33e-03	-0.262000	1.48e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	2.33e-03	-0.262000	1.48e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	2.33e-03	-0.262000	1.48e-02
ABC-family proteins mediated transport	81	4.62e-05	-0.262000	5.07e-04
RND2 GTPase cycle	37	5.93e-03	0.261000	3.12e-02
FGFR2 alternative splicing	25	2.39e-02	-0.261000	8.23e-02
DNA Damage Recognition in GG-NER	38	5.41e-03	-0.261000	2.90e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	2.69e-01	0.260000	4.57e-01
Activated NTRK2 signals through FRS2 and FRS3	8	2.03e-01	0.260000	3.77e-01
Cross-presentation of particulate exogenous antigens (phagosomes)	8	2.03e-01	-0.260000	3.77e-01
Signaling by LTK in cancer	7	2.33e-01	0.260000	4.14e-01
Butyrophilin (BTN) family interactions	9	1.77e-01	-0.260000	3.43e-01
Pyroptosis	25	2.45e-02	-0.260000	8.34e-02
Sodium/Calcium exchangers	9	1.78e-01	-0.260000	3.44e-01
FCERI mediated Ca+2 mobilization	92	1.85e-05	0.258000	2.19e-04
Common Pathway of Fibrin Clot Formation	13	1.07e-01	0.258000	2.38e-01
Negative epigenetic regulation of rRNA expression	63	4.02e-04	-0.258000	3.30e-03
Metabolism of folate and pterines	16	7.47e-02	-0.257000	1.86e-01
Chromosome Maintenance	103	6.45e-06	-0.257000	8.64e-05
Cleavage of the damaged pyrimidine	27	2.07e-02	-0.257000	7.36e-02
Depyrimidination	27	2.07e-02	-0.257000	7.36e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	2.07e-02	-0.257000	7.36e-02
Lysosome Vesicle Biogenesis	32	1.21e-02	-0.256000	5.15e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	2.12e-02	-0.256000	7.48e-02
Hedgehog ‘on’ state	65	3.55e-04	-0.256000	2.98e-03
Fertilization	12	1.25e-01	-0.256000	2.69e-01
Interleukin-15 signaling	14	9.75e-02	0.256000	2.24e-01
Smooth Muscle Contraction	34	1.00e-02	-0.255000	4.51e-02
TRP channels	22	3.83e-02	0.255000	1.15e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	3.87e-02	0.255000	1.15e-01
Dissolution of Fibrin Clot	12	1.27e-01	-0.254000	2.73e-01
Small interfering RNA (siRNA) biogenesis	9	1.87e-01	0.254000	3.55e-01
RHOV GTPase cycle	36	8.49e-03	0.253000	4.02e-02
PI-3K cascade:FGFR2	13	1.14e-01	0.253000	2.50e-01
Telomere C-strand (Lagging Strand) Synthesis	34	1.07e-02	-0.253000	4.72e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	5.03e-02	-0.253000	1.39e-01
Macroautophagy	128	8.53e-07	-0.252000	1.30e-05
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	86	5.43e-05	0.252000	5.83e-04
Formyl peptide receptors bind formyl peptides and many other ligands	7	2.49e-01	-0.252000	4.34e-01
Signaling by MAPK mutants	6	2.86e-01	0.251000	4.75e-01
Germ layer formation at gastrulation	9	1.92e-01	0.251000	3.63e-01
Bicarbonate transporters	9	1.92e-01	0.251000	3.63e-01
FGFR2 mutant receptor activation	23	3.72e-02	-0.251000	1.12e-01
Detoxification of Reactive Oxygen Species	30	1.75e-02	-0.251000	6.51e-02
Translesion Synthesis by POLH	18	6.57e-02	-0.251000	1.69e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	5.01e-03	-0.250000	2.76e-02
HIV Transcription Elongation	42	5.01e-03	-0.250000	2.76e-02
Tat-mediated elongation of the HIV-1 transcript	42	5.01e-03	-0.250000	2.76e-02
Nucleotide Excision Repair	108	7.13e-06	-0.250000	9.44e-05
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.06e-01	-0.249000	2.37e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	9.46e-02	-0.249000	2.18e-01
Assembly of active LPL and LIPC lipase complexes	10	1.73e-01	0.249000	3.38e-01
RHOT1 GTPase cycle	5	3.37e-01	0.248000	5.33e-01
Adherens junctions interactions	41	6.00e-03	0.248000	3.14e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	3.19e-02	0.248000	9.99e-02
Insulin receptor recycling	24	3.56e-02	-0.248000	1.08e-01
Aggrephagy	34	1.27e-02	-0.247000	5.34e-02
Downstream TCR signaling	89	5.66e-05	-0.247000	5.98e-04
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	4.63e-03	0.247000	2.59e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	2.03e-02	-0.245000	7.26e-02
GRB2 events in EGFR signaling	11	1.61e-01	0.244000	3.21e-01
Advanced glycosylation endproduct receptor signaling	12	1.44e-01	-0.244000	2.94e-01
DAG and IP3 signaling	34	1.40e-02	0.243000	5.64e-02
Processive synthesis on the C-strand of the telomere	19	6.63e-02	-0.243000	1.70e-01
Regulation of signaling by CBL	22	4.83e-02	0.243000	1.36e-01
NOTCH2 intracellular domain regulates transcription	11	1.64e-01	0.242000	3.25e-01
Intrinsic Pathway of Fibrin Clot Formation	15	1.04e-01	-0.242000	2.35e-01
Defective LFNG causes SCDO3	5	3.48e-01	0.242000	5.43e-01
Activation of GABAB receptors	31	1.96e-02	0.242000	7.10e-02
GABA B receptor activation	31	1.96e-02	0.242000	7.10e-02
Nef Mediated CD4 Down-regulation	9	2.09e-01	-0.242000	3.83e-01
UCH proteinases	73	3.55e-04	-0.242000	2.98e-03
Extension of Telomeres	51	2.85e-03	-0.241000	1.76e-02
PI3K events in ERBB4 signaling	6	3.06e-01	0.241000	4.98e-01
Regulation of beta-cell development	22	5.02e-02	0.241000	1.39e-01
GABA receptor activation	38	1.02e-02	0.241000	4.55e-02
Degradation of beta-catenin by the destruction complex	72	4.11e-04	-0.241000	3.36e-03
Removal of the Flap Intermediate from the C-strand	17	8.57e-02	-0.241000	2.04e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	7.73e-02	-0.241000	1.89e-01
Gluconeogenesis	19	6.96e-02	-0.240000	1.76e-01
RHOB GTPase cycle	65	8.10e-04	0.240000	6.03e-03
Netrin-1 signaling	35	1.40e-02	0.240000	5.64e-02
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	4.64e-02	-0.240000	1.32e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.29e-02	0.240000	5.40e-02
mRNA 3’-end processing	57	1.77e-03	-0.239000	1.20e-02
Regulation of PTEN localization	9	2.15e-01	-0.239000	3.90e-01
Pre-NOTCH Processing in Golgi	18	7.94e-02	0.239000	1.93e-01
POLB-Dependent Long Patch Base Excision Repair	8	2.42e-01	-0.239000	4.26e-01
Mismatch Repair	15	1.09e-01	-0.239000	2.42e-01
Classical antibody-mediated complement activation	69	6.12e-04	0.238000	4.73e-03
TYSND1 cleaves peroxisomal proteins	7	2.75e-01	-0.238000	4.63e-01
VxPx cargo-targeting to cilium	19	7.31e-02	0.238000	1.83e-01
Interleukin-2 family signaling	38	1.13e-02	0.237000	4.87e-02
Biosynthesis of EPA-derived SPMs	6	3.15e-01	0.237000	5.08e-01
RHOQ GTPase cycle	55	2.40e-03	0.237000	1.51e-02
Regulation of Expression and Function of Type II Classical Cadherins	25	4.07e-02	0.236000	1.20e-01
Regulation of Homotypic Cell-Cell Adhesion	25	4.07e-02	0.236000	1.20e-01
Cytochrome c-mediated apoptotic response	13	1.40e-01	-0.236000	2.89e-01
Glucuronidation	9	2.20e-01	-0.236000	3.98e-01
RHOC GTPase cycle	72	5.84e-04	0.234000	4.55e-03
Interleukin-21 signaling	9	2.25e-01	0.234000	4.03e-01
DNA replication initiation	8	2.53e-01	-0.233000	4.38e-01
Metabolism of steroid hormones	22	5.89e-02	-0.233000	1.57e-01
Receptor Mediated Mitophagy	11	1.83e-01	-0.232000	3.52e-01
Membrane binding and targetting of GAG proteins	13	1.49e-01	-0.231000	3.02e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	1.49e-01	-0.231000	3.02e-01
RNA Polymerase III Transcription Initiation	36	1.65e-02	-0.231000	6.24e-02
mRNA decay by 3’ to 5’ exoribonuclease	13	1.50e-01	-0.231000	3.03e-01
Effects of PIP2 hydrolysis	24	5.06e-02	0.230000	1.40e-01
Activation of RAC1	11	1.88e-01	0.229000	3.56e-01
PRC2 methylates histones and DNA	27	3.92e-02	-0.229000	1.16e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	1.45e-02	-0.229000	5.81e-02
Nucleosome assembly	38	1.45e-02	-0.229000	5.81e-02
Downstream signaling of activated FGFR4	18	9.27e-02	0.229000	2.16e-01
Telomere C-strand synthesis initiation	13	1.54e-01	-0.229000	3.09e-01
Constitutive Signaling by Aberrant PI3K in Cancer	59	2.41e-03	0.228000	1.51e-02
RAS signaling downstream of NF1 loss-of-function variants	7	2.96e-01	0.228000	4.86e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	2.64e-01	-0.228000	4.51e-01
Class B/2 (Secretin family receptors)	55	3.46e-03	0.228000	2.04e-02
HIV Infection	213	1.02e-08	-0.228000	1.80e-07
Autophagy	142	2.99e-06	-0.227000	4.18e-05
CD28 dependent PI3K/Akt signaling	22	6.57e-02	0.227000	1.69e-01
Receptor-type tyrosine-protein phosphatases	12	1.75e-01	0.226000	3.39e-01
RNA Polymerase I Transcription Initiation	47	7.26e-03	-0.226000	3.65e-02
Anti-inflammatory response favouring Leishmania parasite infection	132	7.48e-06	0.226000	9.57e-05
Leishmania parasite growth and survival	132	7.48e-06	0.226000	9.57e-05
Formation of HIV elongation complex in the absence of HIV Tat	44	9.62e-03	-0.226000	4.38e-02
Regulation of CDH11 Expression and Function	23	6.17e-02	0.225000	1.63e-01
Signaling by PDGF	50	5.98e-03	0.225000	3.14e-02
Sema4D mediated inhibition of cell attachment and migration	7	3.03e-01	-0.225000	4.95e-01
Downstream signaling of activated FGFR3	17	1.09e-01	0.225000	2.41e-01
Neurexins and neuroligins	40	1.40e-02	0.224000	5.64e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	3.04e-01	0.224000	4.96e-01
Degradation of cysteine and homocysteine	13	1.63e-01	-0.223000	3.24e-01
DNA methylation	18	1.01e-01	-0.223000	2.29e-01
Signaling by EGFR	48	7.51e-03	0.223000	3.74e-02
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	2.01e-01	-0.222000	3.76e-01
PECAM1 interactions	12	1.82e-01	0.222000	3.51e-01
ECM proteoglycans	48	7.69e-03	0.222000	3.77e-02
Collagen degradation	44	1.07e-02	0.222000	4.72e-02
Ca-dependent events	30	3.51e-02	0.222000	1.07e-01
ATF4 activates genes in response to endoplasmic reticulum stress	25	5.44e-02	-0.222000	1.47e-01
Transport of nucleotide sugars	9	2.48e-01	-0.222000	4.34e-01
Glycogen synthesis	11	2.03e-01	-0.222000	3.77e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	2.78e-01	0.222000	4.65e-01
Mitochondrial Uncoupling	6	3.48e-01	-0.221000	5.43e-01
Glutathione synthesis and recycling	10	2.26e-01	-0.221000	4.05e-01
Triglyceride catabolism	16	1.26e-01	0.221000	2.72e-01
NADE modulates death signalling	5	3.93e-01	-0.221000	5.82e-01
RHOU GTPase cycle	40	1.58e-02	0.221000	6.11e-02
Pyrimidine catabolism	9	2.52e-01	-0.220000	4.37e-01
Processing of Capped Intronless Pre-mRNA	29	3.99e-02	-0.220000	1.18e-01
Signaling by FLT3 ITD and TKD mutants	15	1.40e-01	0.220000	2.89e-01
Interleukin-6 family signaling	20	8.93e-02	0.219000	2.10e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	3.15e-01	0.219000	5.08e-01
Reactions specific to the complex N-glycan synthesis pathway	7	3.15e-01	0.219000	5.08e-01
Acyl chain remodelling of PS	14	1.55e-01	-0.219000	3.12e-01
Senescence-Associated Secretory Phenotype (SASP)	65	2.23e-03	-0.219000	1.47e-02
G2 Phase	5	3.98e-01	-0.218000	5.88e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	17	1.20e-01	0.218000	2.61e-01
tRNA modification in the nucleus and cytosol	43	1.38e-02	-0.217000	5.64e-02
Hedgehog ‘off’ state	91	3.45e-04	-0.217000	2.93e-03
CREB phosphorylation	7	3.21e-01	0.216000	5.15e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	3.23e-01	0.215000	5.18e-01
RHOJ GTPase cycle	50	8.43e-03	0.215000	4.00e-02
RHOBTB GTPase Cycle	35	2.79e-02	-0.215000	9.07e-02
Ca2+ pathway	58	4.67e-03	0.215000	2.61e-02
Pausing and recovery of Tat-mediated HIV elongation	30	4.18e-02	-0.215000	1.22e-01
Tat-mediated HIV elongation arrest and recovery	30	4.18e-02	-0.215000	1.22e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	1.05e-01	0.215000	2.36e-01
PKMTs methylate histone lysines	44	1.39e-02	0.214000	5.64e-02
Creation of C4 and C2 activators	71	1.80e-03	0.214000	1.21e-02
Signaling by ERBB2 ECD mutants	15	1.51e-01	0.214000	3.05e-01
Collagen chain trimerization	29	4.59e-02	0.214000	1.31e-01
Iron uptake and transport	52	7.62e-03	-0.214000	3.76e-02
Sulfur amino acid metabolism	23	7.60e-02	-0.214000	1.88e-01
Protein-protein interactions at synapses	61	3.92e-03	0.214000	2.25e-02
Tandem pore domain potassium channels	5	4.08e-01	0.213000	5.95e-01
CDC42 GTPase cycle	141	1.30e-05	0.213000	1.60e-04
Prolonged ERK activation events	13	1.85e-01	0.213000	3.53e-01
FLT3 Signaling	38	2.35e-02	0.212000	8.13e-02
RHOBTB2 GTPase cycle	23	7.80e-02	-0.212000	1.90e-01
Activation of caspases through apoptosome-mediated cleavage	6	3.69e-01	-0.212000	5.66e-01
Plasma lipoprotein assembly	10	2.46e-01	0.212000	4.32e-01
Signaling by NTRK3 (TRKC)	16	1.43e-01	0.212000	2.92e-01
Glycerophospholipid catabolism	6	3.70e-01	-0.211000	5.66e-01
ABC transporters in lipid homeostasis	14	1.72e-01	0.211000	3.37e-01
MAPK6/MAPK4 signaling	69	2.54e-03	-0.210000	1.58e-02
Glucagon signaling in metabolic regulation	26	6.38e-02	0.210000	1.66e-01
AKT phosphorylates targets in the nucleus	9	2.75e-01	0.210000	4.63e-01
Non-integrin membrane-ECM interactions	51	9.63e-03	0.210000	4.38e-02
Peroxisomal protein import	58	5.79e-03	-0.209000	3.07e-02
Laminin interactions	26	6.45e-02	0.209000	1.67e-01
Acyl chain remodelling of PE	20	1.06e-01	-0.209000	2.37e-01
HDL remodeling	6	3.76e-01	-0.209000	5.72e-01
Synthesis of PIPs at the late endosome membrane	11	2.31e-01	0.209000	4.10e-01
Activated NTRK2 signals through RAS	6	3.77e-01	0.208000	5.72e-01
S Phase	150	1.09e-05	-0.208000	1.35e-04
G2/M Checkpoints	126	5.50e-05	-0.208000	5.87e-04
Early SARS-CoV-2 Infection Events	31	4.50e-02	-0.208000	1.30e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	2.14e-01	0.207000	3.89e-01
FGFR4 ligand binding and activation	5	4.24e-01	-0.207000	6.07e-01
Glutamate and glutamine metabolism	12	2.15e-01	0.207000	3.90e-01
G1/S Transition	120	9.35e-05	-0.206000	9.36e-04
Synthesis of bile acids and bile salts	27	6.34e-02	0.206000	1.66e-01
Formation of the ureteric bud	5	4.24e-01	0.206000	6.07e-01
CaM pathway	28	5.90e-02	0.206000	1.57e-01
Calmodulin induced events	28	5.90e-02	0.206000	1.57e-01
Olfactory Signaling Pathway	61	5.36e-03	0.206000	2.89e-02
EGFR downregulation	27	6.41e-02	0.206000	1.67e-01
RND3 GTPase cycle	36	3.26e-02	0.206000	1.02e-01
Pyruvate metabolism	44	1.82e-02	-0.206000	6.68e-02
Interferon alpha/beta signaling	64	4.43e-03	-0.206000	2.51e-02
Chemokine receptors bind chemokines	39	2.63e-02	0.206000	8.72e-02
FasL/ CD95L signaling	5	4.27e-01	0.205000	6.09e-01
TGFBR3 PTM regulation	10	2.61e-01	-0.205000	4.48e-01
B-WICH complex positively regulates rRNA expression	45	1.77e-02	-0.204000	6.56e-02
Assembly Of The HIV Virion	15	1.71e-01	-0.204000	3.35e-01
Processing and activation of SUMO	10	2.64e-01	-0.204000	4.51e-01
WNT mediated activation of DVL	8	3.18e-01	0.204000	5.12e-01
Serine biosynthesis	8	3.20e-01	0.203000	5.14e-01
FCERI mediated MAPK activation	93	7.37e-04	0.203000	5.58e-03
MAPK1 (ERK2) activation	9	2.94e-01	0.202000	4.84e-01
Synthesis of pyrophosphates in the cytosol	8	3.23e-01	0.202000	5.18e-01
tRNA processing in the mitochondrion	24	8.78e-02	-0.201000	2.07e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	2.27e-01	0.201000	4.06e-01
CLEC7A (Dectin-1) signaling	86	1.30e-03	-0.201000	9.14e-03
Signaling by SCF-KIT	40	2.82e-02	0.201000	9.11e-02
p75NTR recruits signalling complexes	12	2.30e-01	-0.200000	4.09e-01
Elevation of cytosolic Ca2+ levels	13	2.12e-01	0.200000	3.86e-01
CYP2E1 reactions	6	3.98e-01	0.199000	5.87e-01
FCGR3A-mediated phagocytosis	121	1.57e-04	0.199000	1.48e-03
Leishmania phagocytosis	121	1.57e-04	0.199000	1.48e-03
Parasite infection	121	1.57e-04	0.199000	1.48e-03
Response of EIF2AK1 (HRI) to heme deficiency	14	1.98e-01	-0.199000	3.71e-01
Interleukin-4 and Interleukin-13 signaling	93	9.48e-04	0.198000	6.96e-03
FOXO-mediated transcription of cell cycle genes	15	1.84e-01	0.198000	3.53e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	1.46e-01	-0.198000	2.98e-01
Positive epigenetic regulation of rRNA expression	60	8.01e-03	-0.198000	3.86e-02
Bile acid and bile salt metabolism	31	5.68e-02	0.198000	1.53e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	2.36e-01	-0.197000	4.17e-01
Transport of connexons to the plasma membrane	12	2.36e-01	-0.197000	4.17e-01
RNA Polymerase III Abortive And Retractive Initiation	41	2.90e-02	-0.197000	9.28e-02
RNA Polymerase III Transcription	41	2.90e-02	-0.197000	9.28e-02
Diseases of branched-chain amino acid catabolism	13	2.19e-01	-0.197000	3.96e-01
PLC beta mediated events	40	3.14e-02	0.197000	9.91e-02
Synthesis of Dolichyl-phosphate	6	4.04e-01	-0.197000	5.92e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	2.21e-01	0.196000	3.99e-01
Fcgamma receptor (FCGR) dependent phagocytosis	147	4.13e-05	0.196000	4.61e-04
NCAM signaling for neurite out-growth	48	1.90e-02	0.196000	6.92e-02
G-protein mediated events	44	2.48e-02	0.196000	8.41e-02
FOXO-mediated transcription	58	1.02e-02	0.195000	4.55e-02
Methylation	13	2.24e-01	-0.195000	4.02e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	6.48e-02	-0.195000	1.68e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	2.08e-01	-0.195000	3.82e-01
NR1H2 and NR1H3-mediated signaling	39	3.56e-02	0.194000	1.08e-01
Keratan sulfate biosynthesis	20	1.32e-01	0.194000	2.79e-01
rRNA modification in the nucleus and cytosol	59	9.87e-03	-0.194000	4.47e-02
TCR signaling	110	4.56e-04	-0.193000	3.66e-03
Cobalamin (Cbl) metabolism	7	3.76e-01	0.193000	5.72e-01
Ion transport by P-type ATPases	43	2.92e-02	0.192000	9.31e-02
Biosynthesis of E-series 18(S)-resolvins	5	4.57e-01	0.192000	6.38e-01
Signaling by NTRK2 (TRKB)	20	1.38e-01	0.192000	2.87e-01
SMAC (DIABLO) binds to IAPs	7	3.80e-01	-0.192000	5.72e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	3.80e-01	-0.192000	5.72e-01
SMAC, XIAP-regulated apoptotic response	7	3.80e-01	-0.192000	5.72e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	2.33e-01	-0.191000	4.13e-01
Regulation of actin dynamics for phagocytic cup formation	123	2.61e-04	0.191000	2.32e-03
Transcription of the HIV genome	67	6.99e-03	-0.191000	3.56e-02
Nuclear Receptor transcription pathway	40	3.78e-02	0.190000	1.13e-01
Phosphate bond hydrolysis by NTPDase proteins	5	4.63e-01	-0.190000	6.43e-01
Signalling to ERKs	32	6.33e-02	0.190000	1.65e-01
Interleukin-1 signaling	99	1.12e-03	-0.189000	8.06e-03
CLEC7A/inflammasome pathway	6	4.23e-01	0.189000	6.07e-01
Nuclear events mediated by NFE2L2	82	3.14e-03	-0.189000	1.90e-02
ARMS-mediated activation	6	4.24e-01	0.189000	6.07e-01
PERK regulates gene expression	30	7.46e-02	-0.188000	1.86e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	6.17e-02	0.188000	1.63e-01
tRNA processing	128	2.42e-04	-0.188000	2.16e-03
Constitutive Signaling by EGFRvIII	14	2.25e-01	0.187000	4.03e-01
Signaling by EGFRvIII in Cancer	14	2.25e-01	0.187000	4.03e-01
PI3K/AKT Signaling in Cancer	85	2.89e-03	0.187000	1.77e-02
Signaling by KIT in disease	20	1.48e-01	0.187000	3.01e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.48e-01	0.187000	3.01e-01
Rap1 signalling	14	2.27e-01	0.186000	4.06e-01
Noncanonical activation of NOTCH3	8	3.61e-01	-0.186000	5.56e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	2.64e-01	0.186000	4.51e-01
Prostacyclin signalling through prostacyclin receptor	16	1.97e-01	-0.186000	3.70e-01
FRS-mediated FGFR1 signaling	15	2.12e-01	0.186000	3.86e-01
Diseases of Base Excision Repair	5	4.72e-01	-0.186000	6.51e-01
G2/M Transition	177	2.13e-05	-0.185000	2.46e-04
Intraflagellar transport	47	2.81e-02	-0.185000	9.11e-02
IRAK2 mediated activation of TAK1 complex	10	3.11e-01	-0.185000	5.05e-01
Interleukin-9 signaling	8	3.65e-01	0.185000	5.61e-01
Recycling of bile acids and salts	10	3.12e-01	0.185000	5.05e-01
Binding and Uptake of Ligands by Scavenger Receptors	94	1.97e-03	0.185000	1.32e-02
Eicosanoid ligand-binding receptors	13	2.49e-01	0.184000	4.35e-01
STAT5 activation downstream of FLT3 ITD mutants	9	3.40e-01	0.184000	5.35e-01
RSK activation	7	4.00e-01	0.184000	5.88e-01
Amino acids regulate mTORC1	48	2.80e-02	-0.183000	9.09e-02
HIV elongation arrest and recovery	32	7.32e-02	-0.183000	1.83e-01
Pausing and recovery of HIV elongation	32	7.32e-02	-0.183000	1.83e-01
Telomere Extension By Telomerase	23	1.29e-01	-0.183000	2.76e-01
Mitotic G2-G2/M phases	179	2.46e-05	-0.183000	2.83e-04
Phase II - Conjugation of compounds	71	7.75e-03	-0.183000	3.78e-02
Acetylcholine Neurotransmitter Release Cycle	11	2.94e-01	-0.183000	4.84e-01
Regulated Necrosis	56	1.82e-02	-0.182000	6.68e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	19	1.70e-01	0.182000	3.35e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	2.09e-01	0.182000	3.83e-01
Constitutive Signaling by Overexpressed ERBB2	11	2.99e-01	0.181000	4.89e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	7.98e-03	-0.181000	3.85e-02
Signalling to RAS	19	1.73e-01	0.180000	3.38e-01
Signaling by PDGFRA extracellular domain mutants	12	2.80e-01	0.180000	4.67e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	2.80e-01	0.180000	4.67e-01
Inactivation of CDC42 and RAC1	7	4.09e-01	0.180000	5.95e-01
Estrogen biosynthesis	5	4.86e-01	0.180000	6.62e-01
Transcriptional regulation of testis differentiation	5	4.86e-01	0.180000	6.62e-01
Metal ion SLC transporters	19	1.75e-01	0.180000	3.40e-01
Nuclear signaling by ERBB4	24	1.28e-01	-0.180000	2.73e-01
Heme degradation	11	3.02e-01	-0.180000	4.95e-01
Regulation of TP53 Activity through Acetylation	29	9.43e-02	0.179000	2.18e-01
Amyloid fiber formation	52	2.52e-02	-0.179000	8.47e-02
Ion homeostasis	42	4.42e-02	0.179000	1.28e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	4.12e-01	-0.179000	5.97e-01
Transcriptional regulation of white adipocyte differentiation	77	6.68e-03	0.179000	3.42e-02
RAC1 GTPase cycle	173	4.97e-05	0.179000	5.39e-04
Activation of NOXA and translocation to mitochondria	5	4.89e-01	0.179000	6.63e-01
Insulin processing	19	1.78e-01	0.179000	3.44e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	50	2.92e-02	0.178000	9.31e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	2.33e-01	-0.178000	4.13e-01
Pyrimidine salvage	10	3.31e-01	-0.178000	5.28e-01
Cell-cell junction organization	60	1.74e-02	0.178000	6.46e-02
Alpha-protein kinase 1 signaling pathway	11	3.10e-01	-0.177000	5.03e-01
Vitamin B1 (thiamin) metabolism	5	4.94e-01	-0.177000	6.66e-01
Hydrolysis of LPC	8	3.87e-01	-0.177000	5.78e-01
Expression and translocation of olfactory receptors	56	2.23e-02	0.176000	7.81e-02
tRNA Aminoacylation	42	4.83e-02	-0.176000	1.36e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	8.58e-02	-0.175000	2.04e-01
PI-3K cascade:FGFR4	11	3.14e-01	0.175000	5.07e-01
SARS-CoV-2-host interactions	183	4.27e-05	-0.175000	4.74e-04
Cardiogenesis	16	2.25e-01	0.175000	4.03e-01
Transport of fatty acids	5	4.99e-01	0.175000	6.71e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	3.39e-01	-0.175000	5.35e-01
Signal regulatory protein family interactions	13	2.77e-01	-0.174000	4.64e-01
Formation of RNA Pol II elongation complex	56	2.43e-02	-0.174000	8.31e-02
RNA Polymerase II Transcription Elongation	56	2.43e-02	-0.174000	8.31e-02
Regulation of Complement cascade	96	3.30e-03	0.174000	1.98e-02
Downstream signal transduction	27	1.20e-01	0.173000	2.61e-01
Signaling by MST1	5	5.03e-01	-0.173000	6.74e-01
Maturation of protein 3a 9683673	9	3.70e-01	0.173000	5.66e-01
Maturation of protein 3a 9694719	9	3.70e-01	0.173000	5.66e-01
Cell recruitment (pro-inflammatory response)	25	1.35e-01	-0.173000	2.84e-01
Purinergic signaling in leishmaniasis infection	25	1.35e-01	-0.173000	2.84e-01
Transport of Mature Transcript to Cytoplasm	81	7.31e-03	-0.172000	3.65e-02
Synthesis of IP3 and IP4 in the cytosol	22	1.63e-01	0.172000	3.24e-01
STAT3 nuclear events downstream of ALK signaling	11	3.24e-01	0.172000	5.18e-01
RHOG GTPase cycle	71	1.24e-02	0.172000	5.24e-02
Processing of DNA double-strand break ends	69	1.39e-02	-0.171000	5.64e-02
Purine ribonucleoside monophosphate biosynthesis	9	3.74e-01	-0.171000	5.70e-01
Interleukin-10 signaling	38	6.84e-02	0.171000	1.74e-01
TLR3-mediated TICAM1-dependent programmed cell death	6	4.70e-01	0.170000	6.49e-01
HIV Life Cycle	144	4.19e-04	-0.170000	3.41e-03
Metabolism of non-coding RNA	53	3.24e-02	-0.170000	1.01e-01
snRNP Assembly	53	3.24e-02	-0.170000	1.01e-01
Beta-oxidation of pristanoyl-CoA	9	3.79e-01	-0.169000	5.72e-01
Transport of RCbl within the body	8	4.08e-01	0.169000	5.95e-01
RNA Polymerase II Pre-transcription Events	77	1.04e-02	-0.169000	4.62e-02
Phospholipase C-mediated cascade; FGFR3	5	5.13e-01	-0.169000	6.83e-01
Regulation of IFNG signaling	14	2.74e-01	0.169000	4.63e-01
Platelet calcium homeostasis	22	1.71e-01	0.169000	3.35e-01
Molecules associated with elastic fibres	26	1.37e-01	0.168000	2.87e-01
Cytosolic sensors of pathogen-associated DNA	63	2.09e-02	-0.168000	7.38e-02
Urea cycle	7	4.41e-01	-0.168000	6.24e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	3.64e-02	-0.168000	1.10e-01
Vitamin B2 (riboflavin) metabolism	6	4.77e-01	-0.168000	6.56e-01
Initial triggering of complement	79	1.07e-02	0.166000	4.72e-02
Transcription of E2F targets under negative control by DREAM complex	19	2.11e-01	0.166000	3.85e-01
Frs2-mediated activation	11	3.41e-01	0.166000	5.36e-01
Cellular responses to stress	698	9.35e-14	-0.165000	3.76e-12
Polo-like kinase mediated events	16	2.52e-01	0.165000	4.37e-01
Cell-Cell communication	114	2.35e-03	0.165000	1.49e-02
FGFRL1 modulation of FGFR1 signaling	7	4.50e-01	0.165000	6.32e-01
trans-Golgi Network Vesicle Budding	69	1.79e-02	-0.165000	6.61e-02
Signaling by FLT3 fusion proteins	18	2.26e-01	0.165000	4.05e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	2.56e-01	-0.164000	4.41e-01
p75NTR negatively regulates cell cycle via SC1	5	5.26e-01	-0.164000	6.93e-01
Transcriptional regulation by RUNX3	81	1.10e-02	-0.163000	4.78e-02
Elastic fibre formation	33	1.04e-01	0.163000	2.35e-01
Separation of Sister Chromatids	168	2.60e-04	-0.163000	2.31e-03
Mitotic G1 phase and G1/S transition	138	9.33e-04	-0.163000	6.88e-03
PI-3K cascade:FGFR3	10	3.72e-01	0.163000	5.69e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	2.75e-01	-0.163000	4.63e-01
Degradation of the extracellular matrix	99	5.13e-03	0.163000	2.80e-02
Glycine degradation	7	4.56e-01	-0.163000	6.37e-01
Growth hormone receptor signaling	21	1.97e-01	0.163000	3.70e-01
Protein folding	83	1.08e-02	-0.162000	4.75e-02
Cardiac conduction	89	8.62e-03	0.161000	4.06e-02
ERK/MAPK targets	22	1.91e-01	0.161000	3.62e-01
Transport of bile salts and organic acids, metal ions and amine compounds	52	4.51e-02	0.161000	1.30e-01
FRS-mediated FGFR2 signaling	15	2.82e-01	0.161000	4.70e-01
Deactivation of the beta-catenin transactivating complex	36	9.57e-02	0.160000	2.20e-01
Cargo concentration in the ER	31	1.23e-01	0.160000	2.65e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	1.29e-01	0.160000	2.76e-01
Digestion	5	5.37e-01	0.160000	7.03e-01
Regulation of MITF-M-dependent genes involved in pigmentation	37	9.32e-02	0.159000	2.17e-01
Late Phase of HIV Life Cycle	131	1.63e-03	-0.159000	1.10e-02
GPCR ligand binding	241	2.05e-05	0.159000	2.40e-04
Cell junction organization	82	1.30e-02	0.159000	5.46e-02
Gastrin-CREB signalling pathway via PKC and MAPK	14	3.04e-01	0.159000	4.96e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	4.68e-01	0.158000	6.47e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	2.60e-02	-0.158000	8.67e-02
Negative regulation of FGFR3 signaling	21	2.09e-01	-0.158000	3.83e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	1.27e-01	0.158000	2.73e-01
G2/M DNA replication checkpoint	5	5.40e-01	0.158000	7.04e-01
Activation of C3 and C5	7	4.68e-01	-0.158000	6.47e-01
Pre-NOTCH Expression and Processing	63	2.98e-02	0.158000	9.48e-02
Activation of the AP-1 family of transcription factors	10	3.86e-01	0.158000	5.78e-01
Circadian Clock	67	2.54e-02	0.158000	8.51e-02
Vasopressin regulates renal water homeostasis via Aquaporins	34	1.14e-01	0.157000	2.49e-01
Response to elevated platelet cytosolic Ca2+	110	4.58e-03	-0.156000	2.57e-02
SHC1 events in ERBB2 signaling	17	2.66e-01	0.156000	4.52e-01
ROS and RNS production in phagocytes	30	1.40e-01	-0.155000	2.90e-01
HDR through Homologous Recombination (HRR)	68	2.69e-02	-0.155000	8.85e-02
LDL clearance	18	2.56e-01	0.155000	4.41e-01
Adipogenesis	96	8.88e-03	0.155000	4.15e-02
Signaling by TGFBR3	39	9.52e-02	0.154000	2.19e-01
Lysosphingolipid and LPA receptors	11	3.77e-01	0.154000	5.72e-01
GABA synthesis, release, reuptake and degradation	12	3.56e-01	-0.154000	5.51e-01
RAC2 GTPase cycle	86	1.38e-02	0.154000	5.64e-02
Signaling by ERBB2 in Cancer	21	2.25e-01	0.153000	4.03e-01
MET receptor recycling	9	4.27e-01	0.153000	6.09e-01
Interleukin-27 signaling	11	3.80e-01	0.153000	5.72e-01
Downregulation of ERBB2:ERBB3 signaling	12	3.59e-01	-0.153000	5.53e-01
Defective binding of VWF variant to GPIb:IX:V	7	4.85e-01	-0.152000	6.62e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	7	4.85e-01	-0.152000	6.62e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	3.42e-01	0.152000	5.37e-01
MHC class II antigen presentation	113	5.24e-03	-0.152000	2.84e-02
IRE1alpha activates chaperones	46	7.49e-02	0.152000	1.86e-01
Glycosphingolipid catabolism	31	1.45e-01	-0.151000	2.95e-01
NrCAM interactions	6	5.21e-01	0.151000	6.91e-01
IFNG signaling activates MAPKs	8	4.59e-01	-0.151000	6.39e-01
Fatty acids	6	5.22e-01	0.151000	6.91e-01
SHC-mediated cascade:FGFR1	13	3.47e-01	0.151000	5.43e-01
MET activates RAP1 and RAC1	10	4.11e-01	0.150000	5.96e-01
Platelet degranulation	106	7.57e-03	-0.150000	3.75e-02
NCAM1 interactions	27	1.78e-01	0.150000	3.44e-01
Phospholipase C-mediated cascade: FGFR1	8	4.63e-01	0.150000	6.43e-01
Drug ADME	59	4.73e-02	-0.149000	1.34e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	4.38e-01	0.149000	6.22e-01
Ras activation upon Ca2+ influx through NMDA receptor	18	2.74e-01	0.149000	4.63e-01
Transcriptional regulation by RUNX2	92	1.37e-02	-0.149000	5.64e-02
Metabolism	1835	4.23e-26	-0.149000	2.40e-24
Lewis blood group biosynthesis	14	3.37e-01	0.148000	5.33e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.91e-01	0.148000	4.81e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.91e-01	0.148000	4.81e-01
Signaling by Activin	14	3.39e-01	0.148000	5.35e-01
MAPK3 (ERK1) activation	10	4.19e-01	0.148000	6.04e-01
Repression of WNT target genes	14	3.40e-01	0.147000	5.35e-01
Diseases of carbohydrate metabolism	29	1.69e-01	-0.147000	3.34e-01
NF-kB is activated and signals survival	12	3.78e-01	-0.147000	5.72e-01
Pre-NOTCH Transcription and Translation	47	8.16e-02	0.147000	1.96e-01
Histidine catabolism	7	5.01e-01	0.147000	6.73e-01
PTK6 promotes HIF1A stabilization	6	5.34e-01	0.147000	7.01e-01
Transferrin endocytosis and recycling	26	1.96e-01	-0.146000	3.69e-01
E3 ubiquitin ligases ubiquitinate target proteins	51	7.06e-02	-0.146000	1.77e-01
Sensory processing of sound by outer hair cells of the cochlea	41	1.05e-01	0.146000	2.36e-01
Extracellular matrix organization	222	1.77e-04	0.146000	1.63e-03
Signaling by Retinoic Acid	29	1.74e-01	-0.146000	3.38e-01
Viral Infection Pathways	776	4.74e-12	-0.146000	1.58e-10
SHC1 events in ERBB4 signaling	10	4.25e-01	0.146000	6.07e-01
Transcriptional activation of mitochondrial biogenesis	52	6.91e-02	0.146000	1.75e-01
Signaling by NTRKs	117	6.49e-03	0.146000	3.34e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	7.53e-02	0.145000	1.87e-01
Respiratory syncytial virus (RSV) attachment and entry	18	2.86e-01	0.145000	4.75e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	4.27e-01	-0.145000	6.09e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	4.51e-01	0.145000	6.33e-01
G alpha (s) signalling events	97	1.35e-02	0.145000	5.62e-02
Maturation of spike protein 9694548	36	1.33e-01	0.145000	2.80e-01
Diseases associated with surfactant metabolism	6	5.39e-01	-0.145000	7.04e-01
Signaling by ERBB2 KD Mutants	20	2.63e-01	0.145000	4.50e-01
Interferon gamma signaling	90	1.79e-02	-0.144000	6.60e-02
G alpha (z) signalling events	36	1.34e-01	0.144000	2.82e-01
Spry regulation of FGF signaling	16	3.18e-01	-0.144000	5.11e-01
Signaling by GPCR	442	1.97e-07	0.144000	3.14e-06
Mitotic Anaphase	211	3.05e-04	-0.144000	2.64e-03
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	5.55e-02	0.144000	1.50e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	2.03e-01	0.144000	3.78e-01
Glycogen breakdown (glycogenolysis)	12	3.88e-01	0.144000	5.78e-01
G alpha (q) signalling events	139	3.40e-03	0.144000	2.01e-02
PI3K events in ERBB2 signaling	11	4.09e-01	0.144000	5.95e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	5.11e-01	0.143000	6.81e-01
Programmed Cell Death	187	7.35e-04	-0.143000	5.58e-03
Condensation of Prophase Chromosomes	27	1.99e-01	-0.143000	3.72e-01
Cell Cycle Checkpoints	246	1.13e-04	-0.143000	1.12e-03
Formation of definitive endoderm	9	4.59e-01	0.143000	6.39e-01
RHO GTPases activate PKNs	46	9.45e-02	-0.142000	2.18e-01
Diseases of programmed cell death	58	6.13e-02	-0.142000	1.62e-01
Class A/1 (Rhodopsin-like receptors)	175	1.22e-03	0.142000	8.68e-03
Mitotic Metaphase and Anaphase	212	3.78e-04	-0.142000	3.13e-03
Cellular responses to stimuli	779	1.77e-11	-0.142000	5.53e-10
Deadenylation-dependent mRNA decay	50	8.34e-02	-0.142000	1.99e-01
Formation of apoptosome	11	4.17e-01	-0.141000	6.02e-01
Regulation of the apoptosome activity	11	4.17e-01	-0.141000	6.02e-01
The activation of arylsulfatases	10	4.39e-01	-0.141000	6.22e-01
Activation of the phototransduction cascade	8	4.89e-01	0.141000	6.63e-01
Regulation of CDH11 gene transcription	5	5.84e-01	0.141000	7.43e-01
TRAIL signaling	8	4.91e-01	0.141000	6.64e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	3.03e-01	0.140000	4.95e-01
Gastrulation	76	3.47e-02	-0.140000	1.06e-01
TP53 Regulates Transcription of DNA Repair Genes	61	5.89e-02	-0.140000	1.57e-01
Complement cascade	100	1.61e-02	0.139000	6.18e-02
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	3.35e-01	-0.139000	5.32e-01
Negative regulation of MET activity	18	3.07e-01	0.139000	5.00e-01
G beta:gamma signalling through BTK	15	3.52e-01	-0.139000	5.48e-01
Pentose phosphate pathway	13	3.87e-01	-0.139000	5.78e-01
Nuclear Events (kinase and transcription factor activation)	54	7.82e-02	0.139000	1.91e-01
Diseases associated with glycosylation precursor biosynthesis	15	3.54e-01	-0.138000	5.49e-01
Glycosaminoglycan metabolism	98	1.83e-02	0.138000	6.71e-02
RA biosynthesis pathway	13	3.90e-01	-0.138000	5.81e-01
Negative regulation of FGFR4 signaling	22	2.64e-01	-0.137000	4.51e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	2.76e-01	-0.137000	4.64e-01
DNA Repair	289	6.02e-05	-0.137000	6.29e-04
Interleukin-35 Signalling	12	4.11e-01	0.137000	5.96e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	1.73e-01	0.137000	3.38e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	1.58e-02	-0.137000	6.11e-02
CRMPs in Sema3A signaling	13	3.93e-01	0.137000	5.82e-01
RAF-independent MAPK1/3 activation	22	2.67e-01	0.137000	4.54e-01
Keratan sulfate/keratin metabolism	28	2.12e-01	0.136000	3.86e-01
Trafficking of GluR2-containing AMPA receptors	11	4.34e-01	-0.136000	6.17e-01
Glyoxylate metabolism and glycine degradation	13	3.96e-01	-0.136000	5.86e-01
RHOA GTPase cycle	139	5.75e-03	0.136000	3.06e-02
IKK complex recruitment mediated by RIP1	23	2.60e-01	-0.136000	4.48e-01
Leishmania infection	211	6.92e-04	0.135000	5.31e-03
Parasitic Infection Pathways	211	6.92e-04	0.135000	5.31e-03
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	5.66e-01	0.135000	7.27e-01
Signaling by MET	68	5.35e-02	0.135000	1.46e-01
eNOS activation	12	4.17e-01	-0.135000	6.02e-01
Chondroitin sulfate/dermatan sulfate metabolism	38	1.49e-01	0.135000	3.02e-01
Integrin cell surface interactions	68	5.40e-02	0.135000	1.47e-01
Metabolism of porphyrins	23	2.63e-01	-0.135000	4.50e-01
Class I peroxisomal membrane protein import	20	2.96e-01	-0.135000	4.87e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	1.40e-01	-0.135000	2.90e-01
Transcriptional regulation of brown and beige adipocyte differentiation	24	2.54e-01	0.135000	4.38e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	24	2.54e-01	0.135000	4.38e-01
Apoptosis	158	3.53e-03	-0.134000	2.07e-02
EGFR Transactivation by Gastrin	7	5.38e-01	0.134000	7.04e-01
Regulation of gene expression in beta cells	8	5.10e-01	0.134000	6.81e-01
Zinc influx into cells by the SLC39 gene family	9	4.86e-01	0.134000	6.62e-01
Striated Muscle Contraction	27	2.28e-01	-0.134000	4.06e-01
The NLRP3 inflammasome	16	3.54e-01	-0.134000	5.49e-01
RMTs methylate histone arginines	35	1.71e-01	-0.134000	3.35e-01
CaMK IV-mediated phosphorylation of CREB	9	4.87e-01	-0.134000	6.62e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.39e-01	-0.134000	2.88e-01
Signaling by RAS mutants	41	1.39e-01	-0.134000	2.88e-01
Signaling by moderate kinase activity BRAF mutants	41	1.39e-01	-0.134000	2.88e-01
Signaling downstream of RAS mutants	41	1.39e-01	-0.134000	2.88e-01
Nuclear events stimulated by ALK signaling in cancer	33	1.84e-01	0.134000	3.53e-01
Regulation of FZD by ubiquitination	16	3.56e-01	0.133000	5.51e-01
Transport of vitamins, nucleosides, and related molecules	32	1.94e-01	-0.133000	3.66e-01
Formation of WDR5-containing histone-modifying complexes	42	1.39e-01	0.132000	2.88e-01
Signaling by ALK fusions and activated point mutants	89	3.16e-02	0.132000	9.92e-02
Signaling by ALK in cancer	89	3.16e-02	0.132000	9.92e-02
Aquaporin-mediated transport	38	1.60e-01	0.132000	3.20e-01
Metabolic disorders of biological oxidation enzymes	26	2.45e-01	-0.132000	4.31e-01
Signaling by Hippo	18	3.35e-01	0.131000	5.32e-01
Neurotransmitter receptors and postsynaptic signal transmission	141	7.14e-03	0.131000	3.61e-02
Estrogen-stimulated signaling through PRKCZ	6	5.78e-01	0.131000	7.37e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	5.48e-01	-0.131000	7.12e-01
Potential therapeutics for SARS	149	5.77e-03	0.131000	3.06e-02
GPCR downstream signalling	398	7.39e-06	0.131000	9.57e-05
MAP2K and MAPK activation	36	1.74e-01	-0.131000	3.39e-01
Chaperonin-mediated protein folding	77	4.72e-02	-0.131000	1.34e-01
Induction of Cell-Cell Fusion	8	5.23e-01	0.130000	6.91e-01
Signaling by Hedgehog	120	1.36e-02	-0.130000	5.64e-02
TNFs bind their physiological receptors	25	2.60e-01	0.130000	4.48e-01
Voltage gated Potassium channels	26	2.51e-01	0.130000	4.37e-01
Homologous DNA Pairing and Strand Exchange	43	1.41e-01	-0.130000	2.90e-01
Axon guidance	459	1.89e-06	-0.130000	2.79e-05
NGF-stimulated transcription	32	2.06e-01	0.129000	3.81e-01
Neuronal System	276	2.25e-04	0.129000	2.03e-03
Transport of inorganic cations/anions and amino acids/oligopeptides	81	4.52e-02	0.129000	1.30e-01
Metabolism of proteins	1777	2.18e-19	-0.129000	1.00e-17
Cell surface interactions at the vascular wall	176	3.40e-03	0.128000	2.01e-02
HDACs deacetylate histones	45	1.38e-01	-0.128000	2.87e-01
Collagen biosynthesis and modifying enzymes	48	1.26e-01	0.128000	2.72e-01
Signaling by NTRK1 (TRKA)	102	2.59e-02	0.128000	8.65e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	2.91e-01	-0.127000	4.81e-01
Homology Directed Repair	110	2.14e-02	-0.127000	7.52e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	4.87e-01	-0.127000	6.62e-01
Biological oxidations	146	8.35e-03	-0.126000	3.97e-02
Integration of energy metabolism	88	4.04e-02	0.126000	1.19e-01
mTORC1-mediated signalling	24	2.84e-01	-0.126000	4.74e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	3.41e-01	-0.126000	5.37e-01
Factors involved in megakaryocyte development and platelet production	129	1.35e-02	0.126000	5.62e-02
tRNA processing in the nucleus	59	9.44e-02	-0.126000	2.18e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	3.84e-01	-0.126000	5.75e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	1.92e-01	0.126000	3.63e-01
Cellular response to chemical stress	179	3.72e-03	-0.126000	2.16e-02
CD28 co-stimulation	33	2.13e-01	0.125000	3.88e-01
Miscellaneous transport and binding events	20	3.35e-01	0.125000	5.32e-01
Generation of second messenger molecules	38	1.84e-01	-0.125000	3.53e-01
Inositol phosphate metabolism	42	1.63e-01	0.125000	3.24e-01
Activation of RAC1 downstream of NMDARs	7	5.68e-01	-0.124000	7.27e-01
Fatty acyl-CoA biosynthesis	35	2.03e-01	0.124000	3.78e-01
Transcriptional regulation by small RNAs	61	9.32e-02	-0.124000	2.17e-01
XBP1(S) activates chaperone genes	44	1.54e-01	0.124000	3.10e-01
HCMV Late Events	67	7.95e-02	-0.124000	1.93e-01
Mitochondrial biogenesis	91	4.11e-02	-0.124000	1.20e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	187	3.58e-03	0.123000	2.10e-02
Reduction of cytosolic Ca++ levels	9	5.22e-01	0.123000	6.91e-01
Scavenging by Class F Receptors	5	6.33e-01	0.123000	7.74e-01
PTEN Regulation	127	1.65e-02	-0.123000	6.24e-02
GPVI-mediated activation cascade	33	2.21e-01	0.123000	3.99e-01
Acyl chain remodeling of CL	5	6.34e-01	0.123000	7.74e-01
Recycling pathway of L1	40	1.79e-01	-0.123000	3.45e-01
Synthesis of GDP-mannose	6	6.03e-01	-0.122000	7.56e-01
Disorders of transmembrane transporters	137	1.39e-02	-0.122000	5.64e-02
SHC-mediated cascade:FGFR2	13	4.49e-01	0.121000	6.31e-01
Digestion and absorption	7	5.78e-01	0.121000	7.37e-01
CD209 (DC-SIGN) signaling	20	3.48e-01	0.121000	5.43e-01
HSF1 activation	26	2.86e-01	-0.121000	4.75e-01
Retinoid metabolism and transport	25	2.97e-01	0.120000	4.88e-01
Signaling by RAF1 mutants	37	2.06e-01	-0.120000	3.81e-01
Diseases associated with N-glycosylation of proteins	20	3.54e-01	-0.120000	5.49e-01
Scavenging by Class A Receptors	14	4.38e-01	-0.120000	6.22e-01
RIPK1-mediated regulated necrosis	31	2.49e-01	-0.120000	4.34e-01
Regulation of necroptotic cell death	31	2.49e-01	-0.120000	4.34e-01
Ub-specific processing proteases	153	1.11e-02	-0.119000	4.78e-02
Signaling by Insulin receptor	63	1.03e-01	0.119000	2.33e-01
Molybdenum cofactor biosynthesis	6	6.15e-01	0.119000	7.62e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	3.97e-01	-0.119000	5.87e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	4.12e-01	0.118000	5.97e-01
Retrograde neurotrophin signalling	12	4.78e-01	-0.118000	6.56e-01
Recruitment of NuMA to mitotic centrosomes	88	5.59e-02	-0.118000	1.51e-01
Depolymerization of the Nuclear Lamina	15	4.29e-01	0.118000	6.12e-01
ATF6 (ATF6-alpha) activates chaperones	12	4.80e-01	-0.118000	6.58e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	5.90e-01	0.118000	7.48e-01
MyD88 deficiency (TLR2/4)	14	4.46e-01	0.118000	6.28e-01
Peroxisomal lipid metabolism	27	2.91e-01	-0.117000	4.81e-01
Reversible hydration of carbon dioxide	8	5.65e-01	0.117000	7.27e-01
Signaling by TGFB family members	139	1.70e-02	0.117000	6.36e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	1.94e-01	-0.117000	3.66e-01
Diseases of DNA Double-Strand Break Repair	41	1.94e-01	-0.117000	3.66e-01
Interleukin-1 processing	8	5.67e-01	0.117000	7.27e-01
Signaling by PDGFR in disease	19	3.78e-01	0.117000	5.72e-01
Regulation of TLR by endogenous ligand	15	4.33e-01	-0.117000	6.17e-01
Loss of Nlp from mitotic centrosomes	69	9.41e-02	-0.117000	2.18e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	9.41e-02	-0.117000	2.18e-01
Nuclear Envelope (NE) Reassembly	68	9.67e-02	-0.116000	2.22e-01
Regulation of PLK1 Activity at G2/M Transition	87	6.05e-02	-0.116000	1.60e-01
ERBB2 Regulates Cell Motility	10	5.24e-01	-0.116000	6.92e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	8.44e-02	-0.116000	2.02e-01
Metabolism of steroids	125	2.51e-02	0.116000	8.45e-02
Nervous system development	478	1.44e-05	-0.116000	1.75e-04
SARS-CoV-2 Infection	267	1.13e-03	-0.116000	8.08e-03
Tie2 Signaling	16	4.24e-01	0.115000	6.07e-01
Sensory processing of sound	58	1.30e-01	0.115000	2.76e-01
NRAGE signals death through JNK	52	1.51e-01	0.115000	3.05e-01
Gamma-carboxylation of protein precursors	6	6.26e-01	0.115000	7.68e-01
Signaling by high-kinase activity BRAF mutants	33	2.53e-01	-0.115000	4.38e-01
SUMOylation of intracellular receptors	26	3.12e-01	0.115000	5.05e-01
Signaling by FGFR3 in disease	14	4.58e-01	0.115000	6.39e-01
Blood group systems biosynthesis	18	4.01e-01	0.114000	5.88e-01
Signaling by NODAL	15	4.46e-01	0.114000	6.28e-01
Transmission across Chemical Synapses	188	7.19e-03	0.114000	3.63e-02
Activation of Matrix Metalloproteinases	22	3.58e-01	0.113000	5.53e-01
Assembly of collagen fibrils and other multimeric structures	44	1.94e-01	0.113000	3.66e-01
Activation of G protein gated Potassium channels	20	3.82e-01	0.113000	5.72e-01
G protein gated Potassium channels	20	3.82e-01	0.113000	5.72e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	3.82e-01	0.113000	5.72e-01
SUMOylation of immune response proteins	12	4.98e-01	-0.113000	6.71e-01
Protein repair	6	6.32e-01	-0.113000	7.74e-01
Miro GTPase Cycle	8	5.81e-01	0.113000	7.40e-01
Keratinization	37	2.36e-01	0.113000	4.17e-01
KEAP1-NFE2L2 pathway	107	4.45e-02	-0.112000	1.28e-01
Inactivation of CSF3 (G-CSF) signaling	24	3.41e-01	-0.112000	5.36e-01
CS/DS degradation	9	5.59e-01	-0.112000	7.23e-01
p75NTR signals via NF-kB	15	4.53e-01	-0.112000	6.34e-01
Peptide ligand-binding receptors	101	5.28e-02	0.112000	1.44e-01
DNA Damage/Telomere Stress Induced Senescence	42	2.11e-01	-0.111000	3.86e-01
p38MAPK events	13	4.87e-01	0.111000	6.62e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	4.03e-01	-0.111000	5.91e-01
Cellular responses to mechanical stimuli	82	8.25e-02	0.111000	1.98e-01
Response of endothelial cells to shear stress	82	8.25e-02	0.111000	1.98e-01
DNA strand elongation	32	2.79e-01	-0.111000	4.67e-01
Centrosome maturation	81	8.55e-02	-0.111000	2.03e-01
Recruitment of mitotic centrosome proteins and complexes	81	8.55e-02	-0.111000	2.03e-01
Norepinephrine Neurotransmitter Release Cycle	14	4.74e-01	-0.110000	6.53e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	3.49e-01	0.110000	5.44e-01
Glycogen storage diseases	13	4.91e-01	-0.110000	6.64e-01
Notch-HLH transcription pathway	28	3.12e-01	0.110000	5.05e-01
M Phase	346	4.27e-04	-0.110000	3.46e-03
RHO GTPase cycle	412	1.30e-04	0.110000	1.27e-03
Acyl chain remodelling of PI	10	5.48e-01	-0.110000	7.12e-01
Translocation of ZAP-70 to Immunological synapse	24	3.53e-01	-0.110000	5.48e-01
Sensory processing of sound by inner hair cells of the cochlea	54	1.64e-01	0.110000	3.25e-01
Association of TriC/CCT with target proteins during biosynthesis	35	2.62e-01	-0.110000	4.50e-01
RHOH GTPase cycle	34	2.71e-01	0.109000	4.59e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	5.51e-01	-0.109000	7.16e-01
Defective EXT2 causes exostoses 2	10	5.51e-01	-0.109000	7.16e-01
G beta:gamma signalling through CDC42	17	4.40e-01	-0.108000	6.24e-01
Regulation of pyruvate metabolism	32	2.90e-01	-0.108000	4.81e-01
Fatty acid metabolism	155	2.05e-02	-0.108000	7.32e-02
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	5.99e-01	0.107000	7.55e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	4.87e-01	-0.107000	6.62e-01
WNT5A-dependent internalization of FZD4	13	5.03e-01	-0.107000	6.74e-01
SLC transporter disorders	77	1.04e-01	0.107000	2.35e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	5.39e-01	-0.107000	7.04e-01
Gain-of-function MRAS complexes activate RAF signaling	8	6.00e-01	-0.107000	7.55e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	6.00e-01	-0.107000	7.55e-01
Signaling by MRAS-complex mutants	8	6.00e-01	-0.107000	7.55e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	6.79e-01	0.107000	8.09e-01
G beta:gamma signalling through PLC beta	17	4.45e-01	-0.107000	6.28e-01
Presynaptic function of Kainate receptors	17	4.45e-01	-0.107000	6.28e-01
Diseases of DNA repair	51	1.88e-01	-0.107000	3.56e-01
DCC mediated attractive signaling	13	5.06e-01	-0.107000	6.76e-01
DARPP-32 events	22	3.87e-01	0.106000	5.78e-01
Formation of the cornified envelope	36	2.69e-01	0.106000	4.57e-01
Cyclin D associated events in G1	47	2.07e-01	-0.106000	3.81e-01
G1 Phase	47	2.07e-01	-0.106000	3.81e-01
Signaling by FGFR1	42	2.36e-01	0.106000	4.17e-01
Signal Transduction	2058	2.42e-15	0.106000	1.02e-13
Neddylation	215	7.97e-03	-0.105000	3.85e-02
Activation of AMPK downstream of NMDARs	20	4.18e-01	-0.105000	6.03e-01
Stimuli-sensing channels	81	1.06e-01	0.104000	2.37e-01
Downregulation of ERBB2 signaling	24	3.79e-01	-0.104000	5.72e-01
RAC3 GTPase cycle	88	9.25e-02	0.104000	2.16e-01
Organelle biogenesis and maintenance	277	2.96e-03	-0.104000	1.81e-02
RND1 GTPase cycle	37	2.75e-01	0.104000	4.63e-01
Ovarian tumor domain proteases	37	2.75e-01	0.104000	4.63e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	2.89e-01	-0.104000	4.80e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	3.90e-01	-0.104000	5.81e-01
Defective B3GAT3 causes JDSSDHD	11	5.53e-01	-0.103000	7.17e-01
DNA Double-Strand Break Repair	137	3.72e-02	-0.103000	1.12e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	2.85e-01	-0.103000	4.75e-01
Fanconi Anemia Pathway	36	2.86e-01	-0.103000	4.75e-01
Diseases of glycosylation	109	6.38e-02	0.103000	1.66e-01
Golgi Associated Vesicle Biogenesis	55	1.87e-01	-0.103000	3.56e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	79	1.15e-01	0.103000	2.51e-01
Kinesins	51	2.05e-01	0.103000	3.80e-01
Downregulation of TGF-beta receptor signaling	26	3.65e-01	-0.103000	5.61e-01
Acyl chain remodelling of PG	11	5.56e-01	-0.103000	7.20e-01
Phospholipid metabolism	183	1.71e-02	0.102000	6.39e-02
Meiosis	67	1.49e-01	-0.102000	3.01e-01
Phospholipase C-mediated cascade; FGFR2	8	6.18e-01	0.102000	7.64e-01
Protein ubiquitination	71	1.38e-01	-0.102000	2.87e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	4.67e-01	-0.102000	6.47e-01
TP53 Regulates Metabolic Genes	78	1.20e-01	-0.102000	2.61e-01
Signaling by ERBB4	45	2.38e-01	-0.102000	4.19e-01
TBC/RABGAPs	45	2.38e-01	0.102000	4.19e-01
TRAF6 mediated IRF7 activation	15	4.96e-01	0.102000	6.69e-01
Basigin interactions	23	4.00e-01	0.101000	5.88e-01
CHL1 interactions	8	6.20e-01	0.101000	7.65e-01
Synthesis of substrates in N-glycan biosythesis	59	1.79e-01	-0.101000	3.46e-01
IkBA variant leads to EDA-ID	7	6.44e-01	0.101000	7.82e-01
Opioid Signalling	75	1.32e-01	0.101000	2.79e-01
Sema3A PAK dependent Axon repulsion	15	5.01e-01	0.100000	6.73e-01
Infectious disease	959	1.63e-07	-0.099800	2.62e-06
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	1.13e-01	0.099500	2.48e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	1.13e-01	0.099500	2.48e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	1.13e-01	0.099500	2.48e-01
Inwardly rectifying K+ channels	24	4.00e-01	0.099200	5.88e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	4.44e-01	0.098900	6.27e-01
NPAS4 regulates expression of target genes	16	4.94e-01	0.098800	6.66e-01
mRNA Editing	8	6.29e-01	0.098700	7.71e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	6.69e-02	0.098100	1.71e-01
RUNX3 regulates WNT signaling	8	6.31e-01	0.098000	7.74e-01
Viral Messenger RNA Synthesis	44	2.63e-01	-0.097600	4.50e-01
Defective B4GALT7 causes EDS, progeroid type	11	5.76e-01	-0.097400	7.35e-01
Metabolism of fat-soluble vitamins	28	3.73e-01	0.097200	5.69e-01
Evasion by RSV of host interferon responses	20	4.52e-01	-0.097100	6.34e-01
Uptake of dietary cobalamins into enterocytes	6	6.81e-01	-0.097000	8.10e-01
Na+/Cl- dependent neurotransmitter transporters	8	6.36e-01	0.096700	7.76e-01
TRAF3-dependent IRF activation pathway	13	5.46e-01	0.096700	7.11e-01
IRF3-mediated induction of type I IFN	12	5.62e-01	-0.096600	7.25e-01
Ca2+ activated K+ channels	6	6.83e-01	-0.096400	8.10e-01
ISG15 antiviral mechanism	72	1.58e-01	-0.096300	3.16e-01
Extra-nuclear estrogen signaling	67	1.73e-01	0.096200	3.38e-01
Signaling by EGFR in Cancer	23	4.25e-01	0.096100	6.07e-01
IRAK4 deficiency (TLR2/4)	15	5.20e-01	0.096000	6.90e-01
RHOT2 GTPase cycle	7	6.62e-01	0.095500	7.96e-01
Signaling by Receptor Tyrosine Kinases	449	5.32e-04	0.095400	4.16e-03
Diseases of mitotic cell cycle	38	3.11e-01	-0.095100	5.04e-01
C-type lectin receptors (CLRs)	118	7.46e-02	-0.095000	1.86e-01
HCMV Infection	106	9.11e-02	-0.095000	2.13e-01
ADORA2B mediated anti-inflammatory cytokines production	36	3.25e-01	0.094700	5.20e-01
Platelet homeostasis	69	1.74e-01	0.094600	3.39e-01
Maturation of nucleoprotein 9694631	15	5.28e-01	0.094200	6.95e-01
Collagen formation	66	1.87e-01	0.094000	3.55e-01
Interleukin-20 family signaling	17	5.03e-01	0.093900	6.74e-01
Regulation of insulin secretion	63	1.98e-01	0.093700	3.71e-01
Gap junction degradation	11	5.92e-01	0.093400	7.50e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	4.19e-01	-0.093400	6.04e-01
Beta-catenin independent WNT signaling	126	7.03e-02	-0.093300	1.77e-01
Cilium Assembly	186	2.87e-02	-0.093000	9.22e-02
Phosphorylation of CD3 and TCR zeta chains	27	4.03e-01	-0.092900	5.92e-01
FGFR2c ligand binding and activation	5	7.19e-01	-0.092900	8.39e-01
Synthesis of 15-eicosatetraenoic acid derivatives	6	6.94e-01	-0.092900	8.21e-01
ER Quality Control Compartment (ERQC)	21	4.61e-01	-0.092900	6.42e-01
Potassium Channels	64	1.99e-01	0.092800	3.72e-01
Activation of kainate receptors upon glutamate binding	26	4.13e-01	0.092700	5.98e-01
FGFR2 ligand binding and activation	9	6.32e-01	0.092200	7.74e-01
Maturation of hRSV A proteins	13	5.65e-01	-0.092200	7.27e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	18	4.99e-01	0.091900	6.72e-01
FGFR3 ligand binding and activation	5	7.23e-01	-0.091600	8.39e-01
FGFR3c ligand binding and activation	5	7.23e-01	-0.091600	8.39e-01
Regulation of lipid metabolism by PPARalpha	107	1.04e-01	0.091100	2.35e-01
GPER1 signaling	38	3.32e-01	0.091000	5.29e-01
Phospholipase C-mediated cascade; FGFR4	6	7.00e-01	-0.090700	8.25e-01
HS-GAG biosynthesis	20	4.83e-01	0.090700	6.60e-01
Sensory Perception	197	2.83e-02	0.090600	9.14e-02
Formation of the beta-catenin:TCF transactivating complex	44	3.01e-01	0.090100	4.93e-01
Apoptotic cleavage of cellular proteins	35	3.57e-01	0.090100	5.51e-01
Uptake and function of diphtheria toxin	6	7.03e-01	-0.089800	8.27e-01
Activation of BH3-only proteins	30	3.96e-01	0.089500	5.86e-01
Interleukin-23 signaling	7	6.82e-01	0.089300	8.10e-01
Kidney development	17	5.24e-01	0.089200	6.92e-01
Estrogen-dependent gene expression	97	1.30e-01	0.089000	2.77e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	5.25e-01	-0.089000	6.93e-01
Beta-oxidation of very long chain fatty acids	11	6.10e-01	0.088800	7.60e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.58e-01	-0.088500	5.53e-01
AURKA Activation by TPX2	72	1.94e-01	-0.088500	3.66e-01
Phase 2 - plateau phase	11	6.12e-01	0.088400	7.61e-01
Signaling by TGF-beta Receptor Complex	91	1.48e-01	0.087800	3.00e-01
Reproduction	85	1.62e-01	-0.087700	3.23e-01
Nonhomologous End-Joining (NHEJ)	40	3.37e-01	-0.087700	5.33e-01
Attenuation phase	23	4.67e-01	0.087600	6.47e-01
Glycogen metabolism	21	4.88e-01	-0.087400	6.62e-01
EPHA-mediated growth cone collapse	21	4.90e-01	0.087100	6.63e-01
ESR-mediated signaling	160	5.80e-02	0.086800	1.56e-01
Negative regulation of FGFR1 signaling	25	4.54e-01	-0.086600	6.35e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	5.37e-01	-0.086400	7.03e-01
Anchoring of the basal body to the plasma membrane	97	1.43e-01	-0.086100	2.92e-01
Signaling by FGFR2 in disease	33	3.93e-01	-0.085900	5.82e-01
Hyaluronan uptake and degradation	12	6.08e-01	-0.085600	7.58e-01
Plasma lipoprotein remodeling	18	5.30e-01	0.085600	6.97e-01
Intra-Golgi traffic	43	3.33e-01	0.085400	5.30e-01
RHO GTPases activate PAKs	20	5.10e-01	0.085200	6.80e-01
Oncogene Induced Senescence	33	3.97e-01	0.085100	5.87e-01
Cell Cycle	611	3.37e-04	-0.084900	2.87e-03
Sphingolipid de novo biosynthesis	34	3.91e-01	0.084900	5.82e-01
Neurotransmitter clearance	6	7.19e-01	-0.084900	8.39e-01
ADP signalling through P2Y purinoceptor 12	18	5.33e-01	-0.084800	7.01e-01
Zinc transporters	12	6.12e-01	0.084500	7.61e-01
WNT ligand biogenesis and trafficking	19	5.25e-01	0.084300	6.93e-01
Chromatin modifying enzymes	215	3.33e-02	0.084200	1.03e-01
Chromatin organization	215	3.33e-02	0.084200	1.03e-01
Branched-chain amino acid catabolism	21	5.06e-01	-0.083900	6.76e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	4.69e-01	0.083600	6.48e-01
MASTL Facilitates Mitotic Progression	10	6.48e-01	0.083400	7.84e-01
Costimulation by the CD28 family	74	2.16e-01	0.083200	3.92e-01
Nuclear Pore Complex (NPC) Disassembly	36	3.93e-01	0.082300	5.82e-01
G alpha (i) signalling events	194	4.82e-02	0.082200	1.36e-01
Killing mechanisms	9	6.72e-01	0.081600	8.03e-01
WNT5:FZD7-mediated leishmania damping	9	6.72e-01	0.081600	8.03e-01
PPARA activates gene expression	105	1.50e-01	0.081300	3.03e-01
DNA Double Strand Break Response	47	3.35e-01	-0.081300	5.32e-01
Biosynthesis of specialized proresolving mediators (SPMs)	17	5.62e-01	0.081200	7.25e-01
The phototransduction cascade	26	4.75e-01	-0.081000	6.54e-01
SUMOylation of transcription factors	16	5.76e-01	-0.080900	7.35e-01
Vitamin D (calciferol) metabolism	11	6.43e-01	-0.080800	7.82e-01
Interferon Signaling	240	3.12e-02	-0.080700	9.88e-02
FRS-mediated FGFR4 signaling	13	6.15e-01	0.080600	7.62e-01
Glycosphingolipid transport	7	7.12e-01	0.080500	8.33e-01
Neurotransmitter release cycle	38	3.91e-01	0.080400	5.82e-01
G-protein activation	19	5.45e-01	-0.080200	7.09e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	6.94e-01	0.080200	8.21e-01
CDC6 association with the ORC:origin complex	8	6.95e-01	-0.080100	8.21e-01
G1/S-Specific Transcription	29	4.56e-01	0.080000	6.37e-01
IL-6-type cytokine receptor ligand interactions	13	6.18e-01	0.079900	7.64e-01
Interleukin-1 family signaling	127	1.22e-01	-0.079600	2.64e-01
Nef Mediated CD8 Down-regulation	7	7.16e-01	-0.079500	8.36e-01
Signaling by activated point mutants of FGFR1	5	7.58e-01	-0.079400	8.62e-01
Signal transduction by L1	20	5.41e-01	-0.078900	7.06e-01
RNA polymerase II transcribes snRNA genes	71	2.52e-01	-0.078600	4.37e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	6.52e-01	0.078600	7.88e-01
ERKs are inactivated	13	6.24e-01	0.078400	7.68e-01
FGFR1c ligand binding and activation	8	7.01e-01	-0.078400	8.25e-01
Impaired BRCA2 binding to RAD51	35	4.24e-01	-0.078100	6.07e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	6.02e-01	-0.077800	7.56e-01
SLC15A4:TASL-dependent IRF5 activation	6	7.41e-01	-0.077800	8.52e-01
Inactivation, recovery and regulation of the phototransduction cascade	25	5.02e-01	-0.077600	6.74e-01
TGFBR3 regulates TGF-beta signaling	8	7.04e-01	0.077500	8.27e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	7.05e-01	-0.077400	8.27e-01
STAT5 Activation	7	7.23e-01	0.077300	8.39e-01
Defective HLCS causes multiple carboxylase deficiency	7	7.24e-01	-0.077000	8.40e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	3.48e-01	-0.076800	5.43e-01
SLC-mediated transmembrane transport	175	8.00e-02	0.076700	1.94e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	3.58e-01	0.076700	5.53e-01
Interleukin-12 signaling	44	3.81e-01	-0.076400	5.72e-01
Uptake and actions of bacterial toxins	28	4.85e-01	0.076300	6.62e-01
Signaling by NOTCH3	44	3.86e-01	0.075500	5.78e-01
Semaphorin interactions	56	3.29e-01	0.075400	5.26e-01
RSV-host interactions	78	2.50e-01	-0.075300	4.35e-01
VEGFA-VEGFR2 Pathway	93	2.10e-01	0.075200	3.84e-01
Hyaluronan metabolism	16	6.04e-01	-0.074800	7.56e-01
Formation of the active cofactor, UDP-glucuronate	5	7.73e-01	-0.074600	8.73e-01
Loss of Function of TGFBR1 in Cancer	7	7.33e-01	-0.074600	8.47e-01
Negative feedback regulation of MAPK pathway	6	7.54e-01	-0.074000	8.59e-01
STING mediated induction of host immune responses	15	6.22e-01	-0.073500	7.67e-01
Acyl chain remodelling of PC	19	5.81e-01	-0.073200	7.40e-01
Ion channel transport	141	1.34e-01	0.073100	2.82e-01
EPHB-mediated forward signaling	40	4.24e-01	-0.073100	6.07e-01
Regulation of TP53 Activity through Phosphorylation	88	2.37e-01	-0.073000	4.18e-01
SUMO E3 ligases SUMOylate target proteins	161	1.12e-01	0.072600	2.47e-01
Signaling by NOTCH	175	9.78e-02	-0.072500	2.24e-01
Activation of HOX genes during differentiation	70	2.94e-01	-0.072500	4.84e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	2.94e-01	-0.072500	4.84e-01
Condensation of Prometaphase Chromosomes	11	6.78e-01	0.072400	8.08e-01
SUMOylation of transcription cofactors	44	4.06e-01	0.072400	5.93e-01
Signaling by Rho GTPases	608	2.38e-03	0.072100	1.51e-02
MAPK family signaling cascades	264	4.39e-02	0.072000	1.27e-01
Late SARS-CoV-2 Infection Events	64	3.19e-01	0.072000	5.13e-01
TNFR1-induced proapoptotic signaling	24	5.43e-01	0.071700	7.08e-01
MET promotes cell motility	33	4.76e-01	0.071700	6.55e-01
GRB2 events in ERBB2 signaling	11	6.82e-01	0.071400	8.10e-01
G0 and Early G1	27	5.22e-01	0.071100	6.91e-01
Chromatin modifications during the maternal to zygotic transition (MZT)	23	5.55e-01	-0.071100	7.19e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	5.64e-01	-0.071000	7.27e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	624	2.50e-03	0.070900	1.57e-02
G beta:gamma signalling through PI3Kgamma	22	5.65e-01	0.070800	7.27e-01
Replacement of protamines by nucleosomes in the male pronucleus	13	6.59e-01	-0.070700	7.94e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	6.72e-01	-0.070700	8.03e-01
Nucleotide biosynthesis	12	6.72e-01	-0.070600	8.03e-01
Signaling by BRAF and RAF1 fusions	60	3.45e-01	-0.070500	5.41e-01
Heparan sulfate/heparin (HS-GAG) metabolism	40	4.41e-01	0.070300	6.24e-01
Synthesis of Ketone Bodies	6	7.66e-01	-0.070300	8.67e-01
MAP kinase activation	63	3.35e-01	0.070300	5.32e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	4.10e-01	-0.070200	5.96e-01
Cell Cycle, Mitotic	488	7.94e-03	-0.070200	3.85e-02
Transport to the Golgi and subsequent modification	171	1.15e-01	0.069900	2.52e-01
Transcriptional regulation of granulopoiesis	44	4.24e-01	0.069700	6.07e-01
SUMOylation	167	1.21e-01	0.069600	2.62e-01
MTOR signalling	39	4.52e-01	-0.069500	6.34e-01
Negative regulation of FGFR2 signaling	24	5.56e-01	-0.069400	7.20e-01
Signaling by FGFR1 in disease	32	4.97e-01	0.069400	6.70e-01
Nuclear Envelope Breakdown	53	3.83e-01	0.069200	5.75e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	3.47e-01	-0.069000	5.43e-01
RAB geranylgeranylation	61	3.52e-01	0.068900	5.48e-01
Mitochondrial tRNA aminoacylation	21	5.85e-01	-0.068800	7.43e-01
Signaling by ERBB2 TMD/JMD mutants	17	6.26e-01	0.068300	7.68e-01
MicroRNA (miRNA) biogenesis	24	5.62e-01	-0.068300	7.25e-01
HDR through MMEJ (alt-NHEJ)	12	6.83e-01	0.068200	8.10e-01
Synthesis of UDP-N-acetyl-glucosamine	8	7.39e-01	0.068100	8.50e-01
G2/M DNA damage checkpoint	66	3.47e-01	-0.067000	5.43e-01
RAB GEFs exchange GTP for GDP on RABs	89	2.75e-01	0.066900	4.63e-01
Negative regulation of FLT3	15	6.54e-01	0.066800	7.89e-01
Nephron development	5	7.98e-01	0.066200	8.89e-01
Biosynthesis of maresin-like SPMs	5	7.99e-01	0.065900	8.89e-01
Erythropoietin activates STAT5	6	7.80e-01	-0.065700	8.77e-01
HSF1-dependent transactivation	30	5.34e-01	0.065500	7.01e-01
DNA Damage Reversal	8	7.49e-01	-0.065400	8.56e-01
Signaling by Interleukins	391	2.68e-02	0.065200	8.85e-02
Interleukin-17 signaling	68	3.59e-01	0.064300	5.53e-01
Translation of Structural Proteins 9694635	56	4.10e-01	0.063600	5.96e-01
Carnitine shuttle	12	7.03e-01	-0.063600	8.27e-01
Deadenylation of mRNA	22	6.06e-01	-0.063500	7.57e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	5.69e-01	0.063400	7.27e-01
Respiratory Syncytial Virus Infection Pathway	99	2.77e-01	-0.063200	4.64e-01
Negative regulation of MAPK pathway	42	4.80e-01	0.063000	6.58e-01
Intracellular signaling by second messengers	268	7.70e-02	0.062800	1.89e-01
Defective factor IX causes hemophilia B	6	7.90e-01	-0.062700	8.85e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	8.09e-01	-0.062500	8.94e-01
Maple Syrup Urine Disease	5	8.09e-01	-0.062500	8.94e-01
RHO GTPases Activate NADPH Oxidases	21	6.20e-01	0.062500	7.65e-01
FRS-mediated FGFR3 signaling	12	7.09e-01	0.062300	8.30e-01
VEGF binds to VEGFR leading to receptor dimerization	5	8.10e-01	0.062200	8.94e-01
VEGF ligand-receptor interactions	5	8.10e-01	0.062200	8.94e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	5.56e-01	-0.062100	7.20e-01
Calnexin/calreticulin cycle	26	5.85e-01	-0.061900	7.43e-01
Regulated proteolysis of p75NTR	11	7.23e-01	0.061800	8.39e-01
Signaling by FGFR2	61	4.04e-01	-0.061800	5.92e-01
LGI-ADAM interactions	9	7.49e-01	-0.061600	8.56e-01
Regulation of CDH11 function	10	7.36e-01	0.061500	8.48e-01
Thyroxine biosynthesis	5	8.12e-01	0.061400	8.95e-01
Signaling by cytosolic FGFR1 fusion mutants	18	6.53e-01	0.061200	7.88e-01
Post-translational protein phosphorylation	70	3.76e-01	0.061100	5.72e-01
Listeria monocytogenes entry into host cells	17	6.64e-01	-0.060900	7.98e-01
Sema4D induced cell migration and growth-cone collapse	19	6.46e-01	0.060800	7.83e-01
TRAF6 mediated NF-kB activation	23	6.14e-01	-0.060700	7.62e-01
Defects of platelet adhesion to exposed collagen	8	7.67e-01	-0.060500	8.68e-01
Neutrophil degranulation	458	2.78e-02	0.060000	9.07e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	6.04e-01	-0.059900	7.56e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	6.04e-01	-0.059900	7.56e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	6.04e-01	-0.059900	7.56e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	6.04e-01	-0.059900	7.56e-01
Diseases of Mismatch Repair (MMR)	5	8.17e-01	0.059900	8.99e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	5.91e-01	-0.059800	7.49e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	7.44e-01	0.059700	8.52e-01
Response of Mtb to phagocytosis	22	6.34e-01	-0.058600	7.74e-01
Post-translational modification: synthesis of GPI-anchored proteins	59	4.37e-01	-0.058600	6.21e-01
RHO GTPases activate KTN1	11	7.37e-01	-0.058500	8.48e-01
Hemostasis	562	1.78e-02	0.058500	6.58e-02
Signaling by VEGF	100	3.14e-01	0.058300	5.07e-01
CDH11 homotypic and heterotypic interactions	6	8.06e-01	-0.058000	8.94e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	11	7.40e-01	-0.057700	8.51e-01
Syndecan interactions	26	6.12e-01	0.057400	7.61e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	4.38e-01	-0.057400	6.22e-01
Assembly and cell surface presentation of NMDA receptors	34	5.67e-01	0.056800	7.27e-01
Meiotic synapsis	43	5.20e-01	-0.056700	6.90e-01
Maternal to zygotic transition (MZT)	72	4.05e-01	0.056700	5.93e-01
Loss of Function of SMAD2/3 in Cancer	7	7.95e-01	0.056600	8.87e-01
Translation of Structural Proteins 9683701	29	5.99e-01	-0.056500	7.55e-01
Integrin signaling	22	6.48e-01	0.056300	7.84e-01
Synthesis of PG	8	7.83e-01	0.056100	8.79e-01
FLT3 signaling in disease	27	6.14e-01	0.056000	7.62e-01
Processing of Intronless Pre-mRNAs	20	6.66e-01	-0.055700	8.00e-01
Synthesis of PC	23	6.44e-01	-0.055600	7.82e-01
Branched-chain ketoacid dehydrogenase kinase deficiency	5	8.30e-01	-0.055400	9.07e-01
Thrombin signalling through proteinase activated receptors (PARs)	27	6.20e-01	-0.055200	7.65e-01
Infection with Mycobacterium tuberculosis	26	6.27e-01	-0.055100	7.69e-01
Regulation of TP53 Activity through Methylation	19	6.78e-01	-0.055000	8.08e-01
NOD1/2 Signaling Pathway	36	5.68e-01	-0.055000	7.27e-01
Signaling by Nuclear Receptors	214	1.66e-01	0.054900	3.29e-01
Signaling by WNT	241	1.43e-01	0.054800	2.92e-01
Tight junction interactions	17	6.98e-01	-0.054400	8.23e-01
Surfactant metabolism	21	6.67e-01	-0.054300	8.00e-01
Activation of the pre-replicative complex	32	5.98e-01	-0.053800	7.55e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	4.92e-01	0.053100	6.64e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	7.42e-01	0.052700	8.52e-01
HCMV Early Events	84	4.04e-01	-0.052600	5.92e-01
TNFR1-induced NF-kappa-B signaling pathway	32	6.07e-01	-0.052500	7.58e-01
E2F-enabled inhibition of pre-replication complex formation	9	7.85e-01	-0.052400	8.80e-01
RHO GTPases activate CIT	18	7.03e-01	-0.052000	8.27e-01
Fc epsilon receptor (FCERI) signaling	179	2.31e-01	0.051900	4.10e-01
Formation of the nephric duct	8	8.00e-01	-0.051800	8.90e-01
CREB3 factors activate genes	6	8.26e-01	-0.051700	9.06e-01
p75 NTR receptor-mediated signalling	89	4.07e-01	-0.050900	5.94e-01
SUMO is proteolytically processed	6	8.29e-01	-0.050800	9.07e-01
Activation of ATR in response to replication stress	37	5.94e-01	-0.050600	7.52e-01
HDR through Single Strand Annealing (SSA)	37	5.94e-01	-0.050600	7.52e-01
Ephrin signaling	18	7.11e-01	-0.050500	8.32e-01
Diseases associated with the TLR signaling cascade	29	6.39e-01	0.050400	7.78e-01
Diseases of Immune System	29	6.39e-01	0.050400	7.78e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	8.45e-01	-0.050300	9.15e-01
TP53 Regulates Transcription of Cell Death Genes	43	5.68e-01	0.050300	7.27e-01
Rab regulation of trafficking	122	3.37e-01	0.050300	5.33e-01
Diseases of hemostasis	15	7.36e-01	0.050200	8.48e-01
Transcriptional Regulation by VENTX	39	5.88e-01	-0.050200	7.46e-01
G alpha (12/13) signalling events	68	4.77e-01	0.049900	6.56e-01
Sensory perception of taste	22	6.86e-01	-0.049800	8.13e-01
Mitochondrial unfolded protein response (UPRmt)	17	7.23e-01	0.049700	8.39e-01
Signaling by NOTCH1	68	4.79e-01	0.049700	6.57e-01
SARS-CoV Infections	433	7.69e-02	-0.049600	1.89e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	7.76e-01	0.049500	8.75e-01
Ketone body metabolism	8	8.09e-01	-0.049400	8.94e-01
Glycolysis	68	4.81e-01	0.049400	6.58e-01
Cellular hexose transport	14	7.49e-01	-0.049300	8.56e-01
Interleukin-12 family signaling	53	5.37e-01	-0.049000	7.03e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	3.80e-01	0.048900	5.72e-01
Toll Like Receptor TLR6:TLR2 Cascade	108	3.80e-01	0.048900	5.72e-01
FGFR1 ligand binding and activation	10	7.93e-01	0.047900	8.86e-01
Vesicle-mediated transport	669	3.46e-02	0.047900	1.06e-01
SUMOylation of RNA binding proteins	47	5.71e-01	-0.047800	7.29e-01
Diseases of signal transduction by growth factor receptors and second messengers	404	9.99e-02	0.047700	2.28e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	6.04e-01	0.046800	7.56e-01
Activated point mutants of FGFR2	7	8.31e-01	0.046600	9.07e-01
Interactions of Vpr with host cellular proteins	37	6.24e-01	-0.046600	7.68e-01
Keratan sulfate degradation	9	8.09e-01	0.046500	8.94e-01
TCF dependent signaling in response to WNT	153	3.21e-01	0.046500	5.15e-01
HATs acetylate histones	92	4.41e-01	-0.046500	6.24e-01
TRIF-mediated programmed cell death	9	8.10e-01	-0.046400	8.94e-01
Signaling by FGFR3	32	6.52e-01	0.046000	7.88e-01
Eicosanoids	6	8.46e-01	-0.045800	9.15e-01
Export of Viral Ribonucleoproteins from Nucleus	33	6.49e-01	0.045800	7.85e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	6.65e-01	0.045700	7.99e-01
Phase I - Functionalization of compounds	70	5.09e-01	-0.045600	6.80e-01
Generic Transcription Pathway	1088	1.20e-02	0.045100	5.11e-02
MAPK1/MAPK3 signaling	232	2.40e-01	0.044800	4.22e-01
COPI-dependent Golgi-to-ER retrograde traffic	90	4.64e-01	0.044600	6.45e-01
Neurotoxicity of clostridium toxins	9	8.17e-01	-0.044400	8.99e-01
Platelet activation, signaling and aggregation	223	2.53e-01	-0.044400	4.38e-01
Class I MHC mediated antigen processing & presentation	344	1.58e-01	-0.044300	3.17e-01
Cell-extracellular matrix interactions	16	7.60e-01	-0.044100	8.64e-01
Axonal growth inhibition (RHOA activation)	7	8.40e-01	-0.044000	9.13e-01
p75NTR regulates axonogenesis	7	8.40e-01	-0.044000	9.13e-01
Toll Like Receptor 4 (TLR4) Cascade	138	3.73e-01	0.044000	5.69e-01
Relaxin receptors	5	8.66e-01	0.043700	9.23e-01
Bacterial Infection Pathways	66	5.40e-01	0.043600	7.04e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	7.43e-01	0.043500	8.52e-01
Formation of the Editosome	6	8.54e-01	0.043400	9.18e-01
mRNA Editing: C to U Conversion	6	8.54e-01	0.043400	9.18e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	8.42e-01	-0.043400	9.15e-01
Transcriptional Regulation by E2F6	34	6.62e-01	-0.043300	7.96e-01
TAK1-dependent IKK and NF-kappa-B activation	43	6.23e-01	-0.043300	7.68e-01
AKT phosphorylates targets in the cytosol	14	7.79e-01	0.043200	8.77e-01
Signaling by ERBB2	44	6.20e-01	0.043200	7.65e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	7.15e-01	0.043100	8.35e-01
Free fatty acids regulate insulin secretion	10	8.14e-01	-0.043000	8.96e-01
Cargo recognition for clathrin-mediated endocytosis	89	4.87e-01	-0.042600	6.62e-01
Defective RIPK1-mediated regulated necrosis	7	8.46e-01	-0.042500	9.15e-01
Cargo trafficking to the periciliary membrane	47	6.18e-01	-0.042100	7.64e-01
Mitotic Spindle Checkpoint	108	4.51e-01	-0.042000	6.33e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	7.58e-01	-0.041900	8.62e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	7.58e-01	-0.041900	8.62e-01
AMPK inhibits chREBP transcriptional activation activity	6	8.60e-01	0.041600	9.19e-01
Cholesterol biosynthesis	26	7.14e-01	0.041500	8.35e-01
Vitamin B5 (pantothenate) metabolism	20	7.49e-01	-0.041300	8.56e-01
Immune System	1841	3.35e-03	0.041200	2.00e-02
COPII-mediated vesicle transport	67	5.61e-01	0.041100	7.24e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	8.06e-01	0.041000	8.94e-01
RUNX3 regulates CDKN1A transcription	7	8.51e-01	0.041000	9.17e-01
Signal amplification	28	7.08e-01	-0.040900	8.30e-01
Synthesis of 5-eicosatetraenoic acids	7	8.53e-01	-0.040400	9.18e-01
Toll Like Receptor 2 (TLR2) Cascade	109	4.66e-01	0.040400	6.45e-01
Toll Like Receptor TLR1:TLR2 Cascade	109	4.66e-01	0.040400	6.45e-01
Caspase activation via Death Receptors in the presence of ligand	16	7.79e-01	-0.040400	8.77e-01
Arachidonate metabolism	45	6.39e-01	-0.040400	7.78e-01
CD28 dependent Vav1 pathway	12	8.10e-01	0.040000	8.94e-01
Cell death signalling via NRAGE, NRIF and NADE	69	5.66e-01	-0.039900	7.27e-01
Sphingolipid metabolism	91	5.12e-01	0.039800	6.82e-01
ADP signalling through P2Y purinoceptor 1	21	7.53e-01	-0.039700	8.58e-01
ER to Golgi Anterograde Transport	145	4.11e-01	0.039600	5.96e-01
Transcriptional Regulation by TP53	346	2.07e-01	-0.039500	3.81e-01
Acetylcholine regulates insulin secretion	9	8.38e-01	-0.039400	9.13e-01
PIWI-interacting RNA (piRNA) biogenesis	23	7.45e-01	-0.039200	8.53e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	7.26e-01	-0.038900	8.41e-01
Glucagon-type ligand receptors	20	7.64e-01	-0.038800	8.66e-01
Intrinsic Pathway for Apoptosis	54	6.23e-01	-0.038600	7.68e-01
Thromboxane signalling through TP receptor	20	7.65e-01	-0.038600	8.67e-01
Golgi-to-ER retrograde transport	123	4.61e-01	0.038500	6.42e-01
Aspirin ADME	16	7.92e-01	0.038000	8.86e-01
Antiviral mechanism by IFN-stimulated genes	140	4.43e-01	-0.037600	6.25e-01
Epigenetic regulation of gene expression	263	2.97e-01	0.037300	4.88e-01
COPI-independent Golgi-to-ER retrograde traffic	45	6.68e-01	-0.037000	8.00e-01
Signaling by FGFR in disease	52	6.45e-01	-0.036900	7.82e-01
Apoptotic cleavage of cell adhesion proteins	8	8.57e-01	-0.036700	9.19e-01
RAF/MAP kinase cascade	226	3.45e-01	0.036500	5.41e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	8.78e-01	-0.036100	9.31e-01
TGFBR1 KD Mutants in Cancer	6	8.78e-01	-0.036100	9.31e-01
MET activates PTK2 signaling	23	7.65e-01	0.036000	8.67e-01
SUMOylation of DNA replication proteins	46	6.72e-01	0.036000	8.03e-01
Disease	1633	1.55e-02	-0.035900	6.11e-02
Dopamine Neurotransmitter Release Cycle	20	7.81e-01	0.035900	8.77e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	3.07e-01	-0.035800	5.00e-01
Toll Like Receptor 3 (TLR3) Cascade	104	5.32e-01	0.035500	7.00e-01
Formation of Fibrin Clot (Clotting Cascade)	26	7.55e-01	0.035400	8.60e-01
Passive transport by Aquaporins	6	8.82e-01	0.035100	9.33e-01
E2F mediated regulation of DNA replication	22	7.76e-01	-0.035000	8.75e-01
PIP3 activates AKT signaling	235	3.56e-01	0.035000	5.51e-01
Maturation of spike protein 9683686	5	8.93e-01	-0.034800	9.41e-01
SUMOylation of DNA methylation proteins	16	8.10e-01	-0.034700	8.94e-01
P2Y receptors	10	8.51e-01	-0.034300	9.17e-01
Biotin transport and metabolism	11	8.44e-01	-0.034300	9.15e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	7.38e-01	0.034200	8.49e-01
Plasma lipoprotein clearance	33	7.34e-01	-0.034100	8.47e-01
RAS processing	23	7.78e-01	-0.034000	8.76e-01
MITF-M-regulated melanocyte development	113	5.36e-01	0.033700	7.03e-01
Metabolism of carbohydrates	241	3.70e-01	0.033500	5.67e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	4.32e-01	0.033000	6.15e-01
Maturation of nucleoprotein 9683610	11	8.50e-01	0.032900	9.17e-01
Impaired BRCA2 binding to PALB2	24	7.81e-01	-0.032700	8.77e-01
GP1b-IX-V activation signalling	12	8.48e-01	-0.031900	9.17e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	6.82e-01	-0.031700	8.10e-01
Carboxyterminal post-translational modifications of tubulin	34	7.51e-01	-0.031500	8.57e-01
Synthesis of PA	31	7.63e-01	-0.031300	8.66e-01
Interactions of Rev with host cellular proteins	37	7.42e-01	-0.031200	8.52e-01
Oncogenic MAPK signaling	76	6.41e-01	-0.031000	7.79e-01
COPI-mediated anterograde transport	92	6.11e-01	0.030700	7.61e-01
Long-term potentiation	18	8.24e-01	0.030300	9.04e-01
Metabolism of vitamins and cofactors	166	5.04e-01	-0.030100	6.74e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	7.35e-01	-0.029900	8.47e-01
Lysine catabolism	11	8.64e-01	-0.029900	9.22e-01
cGMP effects	12	8.58e-01	-0.029800	9.19e-01
Amino acid transport across the plasma membrane	26	7.93e-01	0.029700	8.86e-01
SUMOylation of chromatin organization proteins	57	6.99e-01	-0.029600	8.24e-01
Regulation of TP53 Degradation	35	7.62e-01	-0.029600	8.66e-01
MyD88-independent TLR4 cascade	108	5.99e-01	0.029300	7.55e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	5.99e-01	0.029300	7.55e-01
Gene expression (Transcription)	1413	6.56e-02	0.029200	1.69e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	8.61e-01	0.029200	9.20e-01
alpha-linolenic acid (ALA) metabolism	12	8.61e-01	0.029200	9.20e-01
EPH-Ephrin signaling	81	6.50e-01	-0.029100	7.86e-01
Metabolism of amine-derived hormones	10	8.75e-01	0.028800	9.30e-01
RHO GTPases activate IQGAPs	25	8.04e-01	0.028700	8.92e-01
Presynaptic depolarization and calcium channel opening	8	8.88e-01	0.028700	9.37e-01
Organic anion transporters	7	8.96e-01	-0.028600	9.43e-01
ZBP1(DAI) mediated induction of type I IFNs	20	8.26e-01	0.028400	9.06e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	8.83e-01	0.028400	9.34e-01
Gap junction assembly	17	8.40e-01	-0.028300	9.13e-01
Phase 0 - rapid depolarisation	24	8.11e-01	-0.028300	8.94e-01
Glycerophospholipid biosynthesis	105	6.17e-01	-0.028200	7.64e-01
Signaling by FGFR4	32	7.84e-01	0.028000	8.79e-01
Transport of the SLBP Dependant Mature mRNA	36	7.73e-01	-0.027800	8.73e-01
MITF-M-dependent gene expression	83	6.61e-01	0.027800	7.96e-01
Innate Immune System	971	1.42e-01	0.027800	2.92e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	55	7.22e-01	-0.027700	8.39e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	55	7.22e-01	-0.027700	8.39e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	55	7.22e-01	-0.027700	8.39e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	55	7.22e-01	-0.027700	8.39e-01
Signaling by NOTCH1 in Cancer	55	7.22e-01	-0.027700	8.39e-01
Biosynthesis of maresins	7	8.99e-01	0.027600	9.44e-01
PD-1 signaling	28	8.03e-01	-0.027200	8.92e-01
Reversal of alkylation damage by DNA dioxygenases	7	9.01e-01	0.027200	9.45e-01
RNA Polymerase II Transcription	1206	1.13e-01	0.027100	2.48e-01
Cytoprotection by HMOX1	53	7.34e-01	-0.027000	8.47e-01
Netrin mediated repulsion signals	5	9.17e-01	0.026900	9.57e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	8.19e-01	0.026400	9.00e-01
The canonical retinoid cycle in rods (twilight vision)	9	8.93e-01	-0.025900	9.41e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	8.67e-01	0.025800	9.24e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	8.67e-01	0.025800	9.24e-01
Peptide hormone metabolism	54	7.45e-01	0.025600	8.53e-01
Inflammasomes	21	8.40e-01	-0.025500	9.13e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	6.74e-01	0.025500	8.05e-01
Amplification of signal from the kinetochores	91	6.74e-01	0.025500	8.05e-01
EPH-ephrin mediated repulsion of cells	43	7.74e-01	-0.025400	8.74e-01
A tetrasaccharide linker sequence is required for GAG synthesis	17	8.57e-01	-0.025300	9.19e-01
Diseases associated with glycosaminoglycan metabolism	25	8.28e-01	-0.025100	9.07e-01
Muscle contraction	145	6.03e-01	0.025000	7.56e-01
Regulation of TP53 Activity	153	5.96e-01	0.024800	7.54e-01
Signaling by the B Cell Receptor (BCR)	150	6.06e-01	0.024400	7.57e-01
TGF-beta receptor signaling activates SMADs	45	7.79e-01	0.024200	8.77e-01
Nucleotide-like (purinergic) receptors	13	8.82e-01	-0.023800	9.33e-01
Resolution of Sister Chromatid Cohesion	116	6.62e-01	0.023500	7.96e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	8.71e-01	0.023400	9.26e-01
Amine ligand-binding receptors	10	8.99e-01	0.023200	9.44e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	8.32e-01	-0.023200	9.07e-01
L1CAM interactions	100	6.88e-01	0.023200	8.15e-01
MyD88 cascade initiated on plasma membrane	95	6.98e-01	0.023000	8.23e-01
Toll Like Receptor 10 (TLR10) Cascade	95	6.98e-01	0.023000	8.23e-01
Toll Like Receptor 5 (TLR5) Cascade	95	6.98e-01	0.023000	8.23e-01
Activation of NMDA receptors and postsynaptic events	74	7.32e-01	0.023000	8.47e-01
RAF activation	33	8.19e-01	-0.023000	9.00e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	8.86e-01	-0.022900	9.36e-01
Attachment and Entry 9694614	14	8.84e-01	0.022500	9.34e-01
RHO GTPases Activate WASPs and WAVEs	35	8.18e-01	-0.022500	8.99e-01
Phase 3 - rapid repolarisation	6	9.27e-01	-0.021700	9.62e-01
G-protein beta:gamma signalling	29	8.41e-01	-0.021500	9.14e-01
Regulation of TNFR1 signaling	47	8.00e-01	-0.021400	8.90e-01
Membrane Trafficking	577	3.80e-01	0.021400	5.72e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	8.37e-01	0.021000	9.13e-01
Heme biosynthesis	13	8.97e-01	-0.020700	9.44e-01
ERBB2 Activates PTK6 Signaling	8	9.19e-01	-0.020600	9.58e-01
Attachment of GPI anchor to uPAR	7	9.25e-01	-0.020600	9.61e-01
Metabolism of lipids	642	3.73e-01	0.020600	5.69e-01
FGFR1 mutant receptor activation	25	8.59e-01	0.020600	9.19e-01
Apoptotic execution phase	46	8.11e-01	0.020400	8.94e-01
Synthesis of very long-chain fatty acyl-CoAs	22	8.69e-01	0.020400	9.24e-01
Postmitotic nuclear pore complex (NPC) reformation	27	8.56e-01	-0.020100	9.19e-01
Mitotic Prometaphase	193	6.32e-01	-0.020000	7.74e-01
SHC-mediated cascade:FGFR4	11	9.10e-01	0.019700	9.52e-01
Gap junction trafficking	28	8.58e-01	0.019600	9.19e-01
EML4 and NUDC in mitotic spindle formation	107	7.30e-01	0.019300	8.45e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	9.41e-01	0.019300	9.71e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	9.08e-01	-0.019200	9.51e-01
Glucose metabolism	76	7.77e-01	0.018800	8.75e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	8.52e-01	-0.018500	9.17e-01
Deubiquitination	225	6.33e-01	-0.018500	7.74e-01
Signaling by NOTCH2	33	8.56e-01	-0.018300	9.19e-01
Adaptive Immune System	768	4.00e-01	0.017800	5.88e-01
SUMOylation of ubiquitinylation proteins	39	8.48e-01	0.017700	9.17e-01
Gap junction trafficking and regulation	30	8.68e-01	0.017500	9.24e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	8.45e-01	-0.017400	9.15e-01
Regulation of CDH19 Expression and Function	6	9.41e-01	0.017400	9.71e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	9.15e-01	0.017000	9.56e-01
TNF signaling	56	8.29e-01	-0.016700	9.07e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	7.74e-01	0.016600	8.74e-01
Glycosphingolipid metabolism	46	8.45e-01	0.016600	9.15e-01
NOTCH1 Intracellular Domain Regulates Transcription	46	8.50e-01	0.016100	9.17e-01
Transport of small molecules	558	5.20e-01	0.015900	6.90e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	8.76e-01	0.015900	9.30e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	8.76e-01	0.015900	9.30e-01
Visual phototransduction	60	8.32e-01	0.015900	9.07e-01
Sema4D in semaphorin signaling	22	8.99e-01	0.015700	9.44e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	9.23e-01	-0.015500	9.59e-01
HS-GAG degradation	19	9.08e-01	-0.015300	9.51e-01
Activation of BAD and translocation to mitochondria	15	9.19e-01	-0.015200	9.58e-01
Transcriptional regulation by RUNX1	170	7.33e-01	0.015100	8.47e-01
Nuclear import of Rev protein	34	8.80e-01	-0.015000	9.32e-01
Signaling by Non-Receptor Tyrosine Kinases	47	8.60e-01	-0.014900	9.19e-01
Signaling by PTK6	47	8.60e-01	-0.014900	9.19e-01
Signaling by FGFR	73	8.30e-01	0.014500	9.07e-01
MyD88 dependent cascade initiated on endosome	101	8.02e-01	0.014400	8.92e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	8.68e-01	-0.013800	9.24e-01
Asparagine N-linked glycosylation	286	6.88e-01	-0.013800	8.15e-01
Defective Intrinsic Pathway for Apoptosis	24	9.07e-01	-0.013800	9.51e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	9.58e-01	-0.013600	9.83e-01
RHO GTPases Activate ROCKs	18	9.21e-01	0.013500	9.58e-01
RHO GTPases Activate Formins	128	7.93e-01	-0.013400	8.86e-01
Mucopolysaccharidoses	11	9.39e-01	-0.013400	9.70e-01
FCERI mediated NF-kB activation	129	7.93e-01	-0.013400	8.86e-01
Clathrin-mediated endocytosis	128	7.98e-01	0.013100	8.89e-01
Transport of the SLBP independent Mature mRNA	35	8.95e-01	-0.012900	9.43e-01
Cellular Senescence	143	7.94e-01	-0.012600	8.87e-01
Developmental Biology	929	5.18e-01	-0.012500	6.89e-01
Nitric oxide stimulates guanylate cyclase	15	9.33e-01	0.012500	9.68e-01
Formation of axial mesoderm	6	9.61e-01	-0.011500	9.83e-01
Regulation of endogenous retroelements	92	8.50e-01	-0.011400	9.17e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	9.55e-01	0.011400	9.81e-01
Cytosolic sulfonation of small molecules	18	9.33e-01	-0.011400	9.68e-01
Endogenous sterols	18	9.35e-01	0.011100	9.69e-01
RIP-mediated NFkB activation via ZBP1	17	9.38e-01	0.010800	9.70e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	8.46e-01	0.010800	9.16e-01
Regulation of HMOX1 expression and activity	5	9.68e-01	0.010500	9.87e-01
VEGFR2 mediated cell proliferation	18	9.40e-01	0.010300	9.70e-01
Other interleukin signaling	19	9.39e-01	0.010200	9.70e-01
Glutamate Neurotransmitter Release Cycle	20	9.39e-01	0.009940	9.70e-01
Vpr-mediated nuclear import of PICs	34	9.20e-01	-0.009940	9.58e-01
DAP12 interactions	39	9.15e-01	-0.009870	9.56e-01
NS1 Mediated Effects on Host Pathways	40	9.15e-01	0.009710	9.56e-01
RHOBTB3 ATPase cycle	10	9.60e-01	0.009210	9.83e-01
SUMOylation of DNA damage response and repair proteins	77	8.90e-01	-0.009140	9.38e-01
Toxicity of botulinum toxin type D (botD)	5	9.72e-01	-0.009090	9.90e-01
Toxicity of botulinum toxin type F (botF)	5	9.72e-01	-0.009090	9.90e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	8.76e-01	0.008820	9.30e-01
Cellular response to heat stress	94	8.86e-01	-0.008590	9.35e-01
activated TAK1 mediates p38 MAPK activation	23	9.44e-01	-0.008520	9.72e-01
Cytokine Signaling in Immune system	670	7.09e-01	0.008460	8.30e-01
SHC-mediated cascade:FGFR3	10	9.63e-01	-0.008360	9.84e-01
Post-translational protein modification	1243	6.44e-01	0.007790	7.82e-01
Initiation of Nuclear Envelope (NE) Reformation	19	9.54e-01	0.007570	9.80e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	9.75e-01	0.007410	9.91e-01
Formation of annular gap junctions	10	9.68e-01	0.007350	9.87e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	38	9.38e-01	0.007340	9.70e-01
Sialic acid metabolism	28	9.47e-01	-0.007210	9.75e-01
Rev-mediated nuclear export of HIV RNA	35	9.44e-01	-0.006900	9.72e-01
Regulation of NF-kappa B signaling	18	9.61e-01	-0.006660	9.83e-01
Oxidative Stress Induced Senescence	77	9.24e-01	0.006250	9.61e-01
OAS antiviral response	8	9.77e-01	0.005840	9.91e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	9.59e-01	0.005650	9.83e-01
Toll-like Receptor Cascades	162	9.02e-01	-0.005630	9.46e-01
Transport and synthesis of PAPS	6	9.81e-01	0.005610	9.93e-01
Signaling by CSF3 (G-CSF)	29	9.61e-01	0.005290	9.83e-01
SUMOylation of SUMOylation proteins	35	9.60e-01	0.004880	9.83e-01
CASP8 activity is inhibited	11	9.78e-01	-0.004850	9.91e-01
Dimerization of procaspase-8	11	9.78e-01	-0.004850	9.91e-01
Regulation by c-FLIP	11	9.78e-01	-0.004850	9.91e-01
Death Receptor Signaling	145	9.21e-01	-0.004800	9.58e-01
Toll Like Receptor 9 (TLR9) Cascade	108	9.34e-01	0.004600	9.68e-01
Diseases of metabolism	208	9.11e-01	-0.004510	9.53e-01
Serotonin Neurotransmitter Release Cycle	15	9.76e-01	0.004500	9.91e-01
Platelet Adhesion to exposed collagen	16	9.76e-01	-0.004300	9.91e-01
Gene Silencing by RNA	87	9.46e-01	-0.004160	9.74e-01
Regulation of HSF1-mediated heat shock response	79	9.51e-01	-0.004020	9.78e-01
Nicotinamide salvaging	15	9.79e-01	-0.003970	9.92e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	9.86e-01	-0.003790	9.94e-01
Unfolded Protein Response (UPR)	84	9.53e-01	0.003690	9.80e-01
Metabolism of water-soluble vitamins and cofactors	115	9.46e-01	0.003620	9.74e-01
RHO GTPase Effectors	258	9.20e-01	-0.003620	9.58e-01
Sphingolipid catabolism	11	9.83e-01	-0.003620	9.93e-01
Xenobiotics	12	9.83e-01	-0.003580	9.93e-01
Post NMDA receptor activation events	64	9.63e-01	0.003390	9.84e-01
VEGFR2 mediated vascular permeability	26	9.76e-01	0.003370	9.91e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	9.83e-01	0.003230	9.93e-01
PKR-mediated signaling	67	9.64e-01	0.003170	9.85e-01
Resolution of D-Loop Structures	35	9.77e-01	-0.002830	9.91e-01
Platelet Aggregation (Plug Formation)	30	9.80e-01	0.002710	9.92e-01
Regulation of PTEN gene transcription	59	9.73e-01	-0.002580	9.91e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	9.84e-01	0.002200	9.93e-01
Regulation of TP53 Expression and Degradation	36	9.82e-01	-0.002130	9.93e-01
Nicotinate metabolism	26	9.85e-01	-0.002100	9.94e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	9.88e-01	-0.001970	9.94e-01
Trafficking of AMPA receptors	20	9.88e-01	-0.001970	9.94e-01
Synthesis of PE	12	9.93e-01	0.001530	9.98e-01
Defects in biotin (Btn) metabolism	8	9.94e-01	-0.001460	9.99e-01
Sensing of DNA Double Strand Breaks	6	9.96e-01	0.001300	9.99e-01
Retrograde transport at the Trans-Golgi-Network	49	9.88e-01	-0.001230	9.94e-01
Biosynthesis of DHA-derived SPMs	15	9.94e-01	0.001110	9.99e-01
Mitotic Prophase	96	9.87e-01	0.000966	9.94e-01
N-glycan trimming and elongation in the cis-Golgi	5	9.97e-01	0.000928	9.99e-01
Cytochrome P450 - arranged by substrate type	38	9.96e-01	-0.000477	9.99e-01
Defects in vitamin and cofactor metabolism	21	9.97e-01	-0.000459	9.99e-01
DAP12 signaling	28	9.97e-01	-0.000458	9.99e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	9.98e-01	0.000394	9.99e-01
Neurodegenerative Diseases	21	9.98e-01	0.000394	9.99e-01
Aspartate and asparagine metabolism	9	9.99e-01	-0.000303	9.99e-01
Defects in cobalamin (B12) metabolism	13	9.99e-01	0.000154	9.99e-01

---

Detailed Gene set reports

Peptide chain elongation

set	Peptide chain elongation
setSize	88
pANOVA	4.46e-43
s.dist	-0.847
p.adjustANOVA	8.61e-41

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
EEF1A1	-10262
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
RPL28	-6783
RPS28	-6717
RPS16	-6184
RPL36AL	-4737
RPL3L	-3474
EEF2	-2762
RPL9	-823
RPS26	8715

---

Formation of a pool of free 40S subunits

set	Formation of a pool of free 40S subunits
setSize	100
pANOVA	2.3e-48
s.dist	-0.844
p.adjustANOVA	8.91e-46

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
EIF3H	-10666
RPL12	-10659
RPL7A	-10638
EIF3K	-10630
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EIF3I	-9868
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
EIF3L	-9571
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF3F	-6839
RPL28	-6783
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF3A	-5685
EIF1AX	-5427
RPL36AL	-4737
RPL3L	-3474
RPL9	-823
RPS26	8715

---

Eukaryotic Translation Elongation

set	Eukaryotic Translation Elongation
setSize	93
pANOVA	1.5e-44
s.dist	-0.838
p.adjustANOVA	3.63e-42

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
EEF1B2	-10852
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
EEF1B2	-10852
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
EEF1A1	-10262
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EEF1G	-9914
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
EEF1D	-8856
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
RPL28	-6783
RPS28	-6717
EEF1A1P5	-6220
RPS16	-6184
RPL36AL	-4737
RPL3L	-3474
EEF2	-2762
EEF1A2	-2354
RPL9	-823
RPS26	8715

---

Viral mRNA Translation

set	Viral mRNA Translation
setSize	88
pANOVA	1.48e-41
s.dist	-0.831
p.adjustANOVA	2.38e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
GRSF1	-7591
RPL28	-6783
RPS28	-6717
RPS16	-6184
RPL36AL	-4737
RPL3L	-3474
RPL9	-823
RPS26	8715
DNAJC3	9654

---

SARS-CoV-1 modulates host translation machinery

set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	1.56e-17
s.dist	-0.82
p.adjustANOVA	7.03e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
RPS7	-10812
RPS25	-10741
RPS27A	-10695
RPS6	-10552
RPS12	-10504
RPS10	-10459
HNRNPA1	-10380
RPS9	-10306
RPS3	-10263
EEF1A1	-10262
RPS18	-10158
RPS17	-10118
RPS23	-10051
FAU	-9985

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
RPS7	-10812
RPS25	-10741
RPS27A	-10695
RPS6	-10552
RPS12	-10504
RPS10	-10459
HNRNPA1	-10380
RPS9	-10306
RPS3	-10263
EEF1A1	-10262
RPS18	-10158
RPS17	-10118
RPS23	-10051
FAU	-9985
RPS27	-9692
RPSA	-9646
RPS19	-9394
RPS11	-9331
RPS4X	-9201
RPS21	-8961
RPS5	-8804
RPS15	-8480
RPS14	-8304
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
RPS28	-6717
RPS16	-6184
RPS26	8715

---

Selenocysteine synthesis

set	Selenocysteine synthesis
setSize	92
pANOVA	4.42e-41
s.dist	-0.808
p.adjustANOVA	6.57e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
SARS1	-7729
RPS29	-7614
SECISBP2	-7175
RPL28	-6783
RPS28	-6717
RPS16	-6184
RPL36AL	-4737
EEFSEC	-3510
RPL3L	-3474
PSTK	-1476
RPL9	-823
SEPSECS	3257
SEPHS2	5126
RPS26	8715

---

L13a-mediated translational silencing of Ceruloplasmin expression

set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	110
pANOVA	4.86e-48
s.dist	-0.802
p.adjustANOVA	1.34e-45

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
EIF3H	-10666
RPL12	-10659
RPL7A	-10638
EIF3K	-10630
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EIF3I	-9868
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
EIF3L	-9571
RPL3	-9556
RPL18A	-9497
EIF2S2	-9450
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2S3	-6914
EIF3F	-6839
RPL28	-6783
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF1AX	-5427
RPL36AL	-4737
RPL3L	-3474
EIF4B	-2836
EIF4E	-1272
RPL9	-823
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

Cap-dependent Translation Initiation

set	Cap-dependent Translation Initiation
setSize	118
pANOVA	3.28e-51
s.dist	-0.8
p.adjustANOVA	2.12e-48

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
EIF4EBP1	-11041
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
EIF2B1	-10881
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
EIF4EBP1	-11041
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
EIF2B1	-10881
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
EIF3H	-10666
RPL12	-10659
RPL7A	-10638
EIF3K	-10630
EIF2B2	-10589
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EIF3I	-9868
RPL8	-9862
RPL15	-9812
RPL38	-9802
EIF5	-9800
RPLP2	-9736
RPS27	-9692
RPSA	-9646
EIF3L	-9571
RPL3	-9556
RPL18A	-9497
EIF2S2	-9450
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2B4	-7368
EIF2B3	-7034
EIF2S3	-6914
EIF3F	-6839
RPL28	-6783
RPS28	-6717
EIF2B5	-6644
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF5B	-5523
EIF1AX	-5427
RPL36AL	-4737
RPL3L	-3474
EIF4B	-2836
EIF4E	-1272
RPL9	-823
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

Eukaryotic Translation Initiation

set	Eukaryotic Translation Initiation
setSize	118
pANOVA	3.28e-51
s.dist	-0.8
p.adjustANOVA	2.12e-48

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
EIF4EBP1	-11041
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
EIF2B1	-10881
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
EIF4EBP1	-11041
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
EIF2B1	-10881
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
EIF3H	-10666
RPL12	-10659
RPL7A	-10638
EIF3K	-10630
EIF2B2	-10589
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EIF3I	-9868
RPL8	-9862
RPL15	-9812
RPL38	-9802
EIF5	-9800
RPLP2	-9736
RPS27	-9692
RPSA	-9646
EIF3L	-9571
RPL3	-9556
RPL18A	-9497
EIF2S2	-9450
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2B4	-7368
EIF2B3	-7034
EIF2S3	-6914
EIF3F	-6839
RPL28	-6783
RPS28	-6717
EIF2B5	-6644
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF5B	-5523
EIF1AX	-5427
RPL36AL	-4737
RPL3L	-3474
EIF4B	-2836
EIF4E	-1272
RPL9	-823
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

GTP hydrolysis and joining of the 60S ribosomal subunit

set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	111
pANOVA	3.51e-48
s.dist	-0.799
p.adjustANOVA	1.13e-45

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
EIF3H	-10666
RPL12	-10659
RPL7A	-10638
EIF3K	-10630
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EIF3I	-9868
RPL8	-9862
RPL15	-9812
RPL38	-9802
EIF5	-9800
RPLP2	-9736
RPS27	-9692
RPSA	-9646
EIF3L	-9571
RPL3	-9556
RPL18A	-9497
EIF2S2	-9450
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2S3	-6914
EIF3F	-6839
RPL28	-6783
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF5B	-5523
EIF1AX	-5427
RPL36AL	-4737
RPL3L	-3474
EIF4B	-2836
EIF4E	-1272
RPL9	-823
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

Eukaryotic Translation Termination

set	Eukaryotic Translation Termination
setSize	92
pANOVA	1.01e-39
s.dist	-0.794
p.adjustANOVA	1.4e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
TRMT112	-9981
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
RPL28	-6783
APEH	-6755
RPS28	-6717
RPS16	-6184
RPL36AL	-4737
RPL3L	-3474
RPL9	-823
ETF1	2451
N6AMT1	3707
GSPT2	4986
GSPT1	8226
RPS26	8715

---

Formation of the ternary complex, and subsequently, the 43S complex

set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	4.02e-22
s.dist	-0.782
p.adjustANOVA	2.16e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127
RPS17	-10118

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
FAU	-9985
EIF3I	-9868
RPS27	-9692
RPSA	-9646
EIF3L	-9571
EIF2S2	-9450
RPS19	-9394
RPS11	-9331
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPS5	-8804
RPS15	-8480
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2S3	-6914
EIF3F	-6839
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF3A	-5685
EIF1AX	-5427
EIF2S1	2301
RPS26	8715

---

Phosphate bond hydrolysis by NUDT proteins

set	Phosphate bond hydrolysis by NUDT proteins
setSize	7
pANOVA	0.000396
s.dist	-0.773
p.adjustANOVA	0.00327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUDT5	-10396
NUDT1	-10077
ADPRM	-9880
NUDT15	-8707
NUDT9	-8139
NUDT18	-6643
NUDT16	-6599

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUDT5	-10396
NUDT1	-10077
ADPRM	-9880
NUDT15	-8707
NUDT9	-8139
NUDT18	-6643
NUDT16	-6599

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	94
pANOVA	6.17e-38
s.dist	-0.767
p.adjustANOVA	7.01e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
NCBP2	-7786
RPS29	-7614
RPL28	-6783
RPS28	-6717
RPS16	-6184
RPL36AL	-4737
RPL3L	-3474
NCBP1	-1375
RPL9	-823
ETF1	2451
GSPT2	4986
UPF1	5843
GSPT1	8226
RPS26	8715
EIF4G1	9921

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	100
pANOVA	5.02e-39
s.dist	-0.755
p.adjustANOVA	6.47e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATF4	-11076
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATF4	-11076
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
EIF2S2	-9450
RPS19	-9394
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
DDIT3	-7845
RPS29	-7614
CEBPG	-7140
EIF2S3	-6914
RPL28	-6783
RPS28	-6717
RPS16	-6184
EIF2AK4	-5171
RPL36AL	-4737
RPL3L	-3474
ATF2	-2601
IMPACT	-2257
RPL9	-823
ASNS	839
ATF3	1735
EIF2S1	2301
TRIB3	5517
CEBPB	7802
RPS26	8715
GCN1	9557

---

SRP-dependent cotranslational protein targeting to membrane

set	SRP-dependent cotranslational protein targeting to membrane
setSize	111
pANOVA	6.56e-43
s.dist	-0.753
p.adjustANOVA	1.15e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
SEC11A	-10769
RPL36A	-10764
RPL14	-10763
RPL35A	-10753

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
SEC11A	-10769
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
SSR2	-10510
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
SPCS1	-10349
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
SRP14	-10084
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
RPL35	-9342
RPS11	-9331
SEC61G	-9329
RPL13	-9291
RPL41	-9239
RPS4X	-9201
SRP9	-9022
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPN2	-8225
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
SSR4	-7309
SSR3	-7099
RPL28	-6783
RPS28	-6717
SEC61B	-6546
RPS16	-6184
SEC11C	-5972
RPN1	-5820
SRP19	-5124
SRP68	-4767
RPL36AL	-4737
DDOST	-4676
SEC61A2	-4650
SRPRB	-4374
SRP72	-4161
RPL3L	-3474
SPCS2	-1848
RPL9	-823
TRAM1	150
SRP54	2009
SSR1	2287
SPCS3	2874
SEC61A1	3378
SRPRA	5695
RPS26	8715

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	59
pANOVA	1.25e-22
s.dist	-0.736
p.adjustANOVA	6.91e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
EIF4EBP1	-11041
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
EIF4A1	-10861
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
EIF4EBP1	-11041
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
EIF4A1	-10861
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
FAU	-9985
EIF3I	-9868
RPS27	-9692
RPSA	-9646
EIF3L	-9571
EIF2S2	-9450
RPS19	-9394
PABPC1	-9362
RPS11	-9331
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPS5	-8804
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2S3	-6914
EIF3F	-6839
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF1AX	-5427
EIF4B	-2836
EIF4E	-1272
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

Defective GALNT3 causes HFTC

set	Defective GALNT3 causes HFTC
setSize	9
pANOVA	0.000138
s.dist	0.734
p.adjustANOVA	0.00133

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MUC5B	10396
MUC12	10252
MUC16	10196
MUC4	9700
GALNT3	9497
MUC1	9450
MUC20	6292
MUC6	6093
MUCL1	-472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MUC5B	10396
MUC12	10252
MUC16	10196
MUC4	9700
GALNT3	9497
MUC1	9450
MUC20	6292
MUC6	6093
MUCL1	-472

---

Ribosomal scanning and start codon recognition

set	Ribosomal scanning and start codon recognition
setSize	58
pANOVA	4.64e-22
s.dist	-0.732
p.adjustANOVA	2.42e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
EIF4A1	-10861
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
EIF4A1	-10861
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
FAU	-9985
EIF3I	-9868
EIF5	-9800
RPS27	-9692
RPSA	-9646
EIF3L	-9571
EIF2S2	-9450
RPS19	-9394
RPS11	-9331
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPS5	-8804
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2S3	-6914
EIF3F	-6839
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF1AX	-5427
EIF4B	-2836
EIF4E	-1272
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

Translation initiation complex formation

set	Translation initiation complex formation
setSize	58
pANOVA	5.07e-22
s.dist	-0.732
p.adjustANOVA	2.58e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3M	-11063
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
EIF4A1	-10861
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3M	-11063
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
EIF4A1	-10861
RPS7	-10812
RPS25	-10741
RPS27A	-10695
EIF3H	-10666
EIF3K	-10630
RPS6	-10552
RPS12	-10504
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
EIF3E	-10127
RPS17	-10118
EIF3D	-10064
RPS23	-10051
FAU	-9985
EIF3I	-9868
RPS27	-9692
RPSA	-9646
EIF3L	-9571
EIF2S2	-9450
RPS19	-9394
PABPC1	-9362
RPS11	-9331
RPS4X	-9201
EIF3G	-9071
RPS21	-8961
RPS5	-8804
RPS15	-8480
EIF4A2	-8347
RPS14	-8304
EIF3C	-8255
EIF3J	-8236
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
EIF2S3	-6914
EIF3F	-6839
RPS28	-6717
EIF3B	-6495
RPS16	-6184
EIF4H	-6015
EIF3A	-5685
EIF1AX	-5427
EIF4B	-2836
EIF4E	-1272
EIF2S1	2301
RPS26	8715
EIF4G1	9921

---

Zygotic genome activation (ZGA)

set	Zygotic genome activation (ZGA)
setSize	5
pANOVA	0.00485
s.dist	0.727
p.adjustANOVA	0.0269

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CREBBP	10627
TP53	9458
EP300	8266
DUX4	6711
DPPA4	4270

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CREBBP	10627
TP53	9458
EP300	8266
DUX4	6711
DPPA4	4270

---

Formation of ATP by chemiosmotic coupling

set	Formation of ATP by chemiosmotic coupling
setSize	20
pANOVA	3.03e-08
s.dist	-0.715
p.adjustANOVA	5.09e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5MG	-10783
ATP5F1C	-10712
ATP5MK	-10555
ATP5F1E	-10426
ATP5PB	-10425
ATP5PD	-10417
ATP5PO	-10067
ATP5MJ	-9932
ATP5MC2	-9707
ATP5MC1	-9689
ATP5F1A	-9297
ATP5F1D	-8223
ATP5PF	-8039
ATP5F1B	-7029
ATP5MC3	-6322
DMAC2L	-5292
ATP5MF	-4419
MT-ATP6	-4210
ATP5ME	-3722
MT-ATP8	-605

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5MG	-10783
ATP5F1C	-10712
ATP5MK	-10555
ATP5F1E	-10426
ATP5PB	-10425
ATP5PD	-10417
ATP5PO	-10067
ATP5MJ	-9932
ATP5MC2	-9707
ATP5MC1	-9689
ATP5F1A	-9297
ATP5F1D	-8223
ATP5PF	-8039
ATP5F1B	-7029
ATP5MC3	-6322
DMAC2L	-5292
ATP5MF	-4419
MT-ATP6	-4210
ATP5ME	-3722
MT-ATP8	-605

---

Regulation of NFE2L2 gene expression

set	Regulation of NFE2L2 gene expression
setSize	8
pANOVA	0.000499
s.dist	0.711
p.adjustANOVA	0.00395

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CREBBP	10627
NOTCH1	9760
NFKB1	9318
MYC	9056
EP300	8266
RELA	7909
NFE2L2	4279
MAFK	2234

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CREBBP	10627
NOTCH1	9760
NFKB1	9318
MYC	9056
EP300	8266
RELA	7909
NFE2L2	4279
MAFK	2234

---

Mitochondrial translation initiation

set	Mitochondrial translation initiation
setSize	90
pANOVA	2.71e-30
s.dist	-0.697
p.adjustANOVA	1.81e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS28	-11079
MTIF3	-11037
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MTIF2	-10718
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS28	-11079
MTIF3	-11037
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MTIF2	-10718
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240
MRPL23	-10174
PTCD3	-10147
MT-RNR1	-10092
MRPL20	-10074
MRPL36	-10006
MRPL27	-9973
MRPS15	-9872
MRPL11	-9799
MRPL32	-9751
MRPS11	-9725
MRPS6	-9723
MRPL17	-9672
MRPS24	-9647
MRPL12	-9477
GADD45GIP1	-9364
MRPL33	-9359
MRPS25	-9284
MRPL55	-9264
MRPL57	-9152
MRPL9	-9085
MRPS7	-8981
MRPL40	-8940
MRPL34	-8768
MRPS18B	-8747
MRPS9	-8725
MRPL28	-8723
MRPL44	-8722
MRPS16	-8713
MRPS31	-8684
MRPL47	-8527
MRPL46	-8364
MRPS34	-8321
MRPL24	-8302
MRPS18A	-8293
MRPL14	-8229
MRPS18C	-8095
MRPS26	-8071
MRPS33	-7959
MRPL18	-7909
MRPS17	-7743
MRPL39	-7714
MRPL16	-7623
AURKAIP1	-7274
MRPL22	-7116
MRPL13	-7064
MRPS2	-7005
MRPL35	-6642
MRPL41	-6618
MRPS23	-6496
MRPS27	-5917
MRPL43	-5868
MRPS14	-5772
MRPL38	-5605
MRPL4	-5546
MRPS36	-5283
MRPL1	-5205
MRPL21	-5156
MRPL2	-4972
ERAL1	-4390
MRPL3	-3984
MTFMT	-3487
MRPL42	-3001
MRPS35	-2623
MRPL10	-2545
MRPL30	-1749
MRPL49	-375
MRPL19	1168
MRPS10	1777
MRPS30	3676
MRPL50	4514

---

Selenoamino acid metabolism

set	Selenoamino acid metabolism
setSize	115
pANOVA	3.88e-38
s.dist	-0.696
p.adjustANOVA	4.69e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
AIMP1	-10596
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
HNMT	-10094
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
RPS27	-9692
RPSA	-9646
RPL3	-9556
RARS1	-9534
RPL18A	-9497
KARS1	-9395
RPS19	-9394
AHCY	-9348
RPL35	-9342
RPS11	-9331
DARS1	-9320
RPL13	-9291
RPL41	-9239
RPS4X	-9201
RPS21	-8961
QARS1	-8925
RPLP0	-8912
EEF1E1	-8846
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
SARS1	-7729
RPS29	-7614
SECISBP2	-7175
RPL28	-6783
RPS28	-6717
NNMT	-6415
RPS16	-6184
RPL36AL	-4737
GNMT	-4629
PAPSS1	-4321
AIMP2	-4220
EEFSEC	-3510
RPL3L	-3474
MARS1	-2689
PAPSS2	-2555
INMT	-2047
GSR	-1796
PSTK	-1476
RPL9	-823
LARS1	293
EPRS1	593
SEPSECS	3257
SEPHS2	5126
TXNRD1	5382
CBS	8019
IARS1	8116
RPS26	8715
CTH	8722
SCLY	9474

---

RUNX1 regulates transcription of genes involved in WNT signaling

set	RUNX1 regulates transcription of genes involved in WNT signaling
setSize	5
pANOVA	0.00727
s.dist	0.693
p.adjustANOVA	0.0365

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RUNX1	10701
CBFB	8430
AXIN1	7936
FOXP3	5220
ESR1	5162

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RUNX1	10701
CBFB	8430
AXIN1	7936
FOXP3	5220
ESR1	5162

---

SARS-CoV-2 modulates host translation machinery

set	SARS-CoV-2 modulates host translation machinery
setSize	49
pANOVA	6.84e-17
s.dist	-0.689
p.adjustANOVA	2.94e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
RPS7	-10812
RPS25	-10741
RPS27A	-10695
RPS6	-10552
RPS12	-10504
SNRPE	-10495
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
RPS17	-10118
RPS23	-10051
FAU	-9985
SNRPD1	-9967

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3A	-11038
RPS13	-11023
RPS24	-11010
RPS15A	-10987
RPS8	-10939
RPS20	-10873
RPS7	-10812
RPS25	-10741
RPS27A	-10695
RPS6	-10552
RPS12	-10504
SNRPE	-10495
RPS10	-10459
RPS9	-10306
RPS3	-10263
RPS18	-10158
RPS17	-10118
RPS23	-10051
FAU	-9985
SNRPD1	-9967
RPS27	-9692
RPSA	-9646
RPS19	-9394
RPS11	-9331
RPS4X	-9201
GEMIN8	-9076
RPS21	-8961
RPS5	-8804
RPS15	-8480
SNRPB	-8373
SNRPD2	-8311
RPS14	-8304
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
RPS29	-7614
SNRPD3	-7087
RPS28	-6717
GEMIN7	-6435
GEMIN6	-6266
RPS16	-6184
SNRPG	-5139
SNRPF	-4400
GEMIN2	-4339
SMN1	-3156
GEMIN4	675
DDX20	6573
GEMIN5	7146
RPS26	8715

---

Reelin signalling pathway

set	Reelin signalling pathway
setSize	5
pANOVA	0.00824
s.dist	0.682
p.adjustANOVA	0.0394

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VLDLR	10855
DAB1	9837
RELN	8574
FYN	7280
SH3KBP1	303

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VLDLR	10855
DAB1	9837
RELN	8574
FYN	7280
SH3KBP1	303

---

Mitochondrial translation termination

set	Mitochondrial translation termination
setSize	90
pANOVA	4.06e-29
s.dist	-0.682
p.adjustANOVA	2.53e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS28	-11079
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MRRF	-10804
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240
MRPL23	-10174

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS28	-11079
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MRRF	-10804
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240
MRPL23	-10174
PTCD3	-10147
MT-RNR1	-10092
MRPL20	-10074
MRPL36	-10006
MRPL27	-9973
MRPS15	-9872
MRPL11	-9799
MRPL32	-9751
MRPS11	-9725
MRPS6	-9723
MRPL17	-9672
MRPS24	-9647
MRPL12	-9477
GADD45GIP1	-9364
MRPL33	-9359
MRPS25	-9284
MRPL55	-9264
MRPL57	-9152
MRPL9	-9085
MRPS7	-8981
MRPL40	-8940
MRPL34	-8768
MRPS18B	-8747
MRPS9	-8725
MRPL28	-8723
MRPL44	-8722
MRPS16	-8713
MRPS31	-8684
MRPL47	-8527
MRPL46	-8364
MRPS34	-8321
MRPL24	-8302
MRPS18A	-8293
MRPL14	-8229
MRPS18C	-8095
MRPS26	-8071
MRPS33	-7959
MRPL18	-7909
MRPS17	-7743
MRPL39	-7714
MRPL16	-7623
AURKAIP1	-7274
MRPL22	-7116
GFM2	-7113
MRPL13	-7064
MRPS2	-7005
MRPL35	-6642
MRPL41	-6618
MRPS23	-6496
MRPS27	-5917
MRPL43	-5868
MRPS14	-5772
MRPL38	-5605
MRPL4	-5546
MRPS36	-5283
MRPL1	-5205
MRPL21	-5156
MRPL2	-4972
ERAL1	-4390
MRPL3	-3984
MRPL42	-3001
MRPS35	-2623
MRPL10	-2545
MRPL30	-1749
MRPL49	-375
MRPL19	1168
MRPS10	1777
MRPS30	3676
MRPL50	4514
MTRF1L	6873

---

Mitochondrial translation elongation

set	Mitochondrial translation elongation
setSize	90
pANOVA	5.7e-29
s.dist	-0.68
p.adjustANOVA	3.44e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS28	-11079
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240
MRPL23	-10174
PTCD3	-10147

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS28	-11079
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240
MRPL23	-10174
PTCD3	-10147
MT-RNR1	-10092
MRPL20	-10074
MRPL36	-10006
MRPL27	-9973
MRPS15	-9872
MRPL11	-9799
MRPL32	-9751
MRPS11	-9725
MRPS6	-9723
MRPL17	-9672
MRPS24	-9647
MRPL12	-9477
GADD45GIP1	-9364
MRPL33	-9359
MRPS25	-9284
MRPL55	-9264
MRPL57	-9152
MRPL9	-9085
MRPS7	-8981
MRPL40	-8940
MRPL34	-8768
MRPS18B	-8747
MRPS9	-8725
MRPL28	-8723
MRPL44	-8722
MRPS16	-8713
MRPS31	-8684
MRPL47	-8527
MRPL46	-8364
MRPS34	-8321
TSFM	-8315
MRPL24	-8302
MRPS18A	-8293
MRPL14	-8229
TUFM	-8151
MRPS18C	-8095
MRPS26	-8071
MRPS33	-7959
MRPL18	-7909
MRPS17	-7743
MRPL39	-7714
MRPL16	-7623
AURKAIP1	-7274
MRPL22	-7116
MRPL13	-7064
MRPS2	-7005
MRPL35	-6642
MRPL41	-6618
MRPS23	-6496
MRPS27	-5917
MRPL43	-5868
MRPS14	-5772
MRPL38	-5605
MRPL4	-5546
MRPS36	-5283
MRPL1	-5205
MRPL21	-5156
MRPL2	-4972
ERAL1	-4390
MRPL3	-3984
MRPL42	-3001
MRPS35	-2623
MRPL10	-2545
MRPL30	-1749
MRPL49	-375
MRPL19	1168
MRPS10	1777
MRPS30	3676
MRPL50	4514
GFM1	7225

---

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

set	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
setSize	9
pANOVA	0.000443
s.dist	0.676
p.adjustANOVA	0.00357

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NFATC2	10726
RUNX1	10701
CR1	10568
TNFRSF18	9874
CBFB	8430
CTLA4	5961
FOXP3	5220
IL2RA	4978
IFNG	-747

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NFATC2	10726
RUNX1	10701
CR1	10568
TNFRSF18	9874
CBFB	8430
CTLA4	5961
FOXP3	5220
IL2RA	4978
IFNG	-747

---

Processing of SMDT1

set	Processing of SMDT1
setSize	15
pANOVA	6.49e-06
s.dist	-0.672
p.adjustANOVA	8.64e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MICU1	-10693
MCUB	-10558
PMPCB	-9585
PHB2	-9564
MCU	-9541
PARL	-9493
MICU3	-9094
AFG3L2	-8423
PMPCA	-7875
PHB	-7255
STOML2	-6565
SMDT1	-6462
MICU2	-5718
YME1L1	-2657
SPG7	623

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MICU1	-10693
MCUB	-10558
PMPCB	-9585
PHB2	-9564
MCU	-9541
PARL	-9493
MICU3	-9094
AFG3L2	-8423
PMPCA	-7875
PHB	-7255
STOML2	-6565
SMDT1	-6462
MICU2	-5718
YME1L1	-2657
SPG7	623

---

Mitochondrial translation

set	Mitochondrial translation
setSize	96
pANOVA	4.69e-30
s.dist	-0.672
p.adjustANOVA	3.02e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS28	-11079
MTIF3	-11037
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MRRF	-10804
MTIF2	-10718
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS28	-11079
MTIF3	-11037
MRPL52	-11031
MRPL37	-10968
OXA1L	-10961
DAP3	-10920
MRRF	-10804
MTIF2	-10718
MRPL15	-10691
MRPS22	-10639
MRPL54	-10610
CHCHD1	-10547
RPS12	-10504
MRPL45	-10451
MRPL58	-10423
MRPS21	-10319
MRPL53	-10314
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
MRPL51	-10240
MRPL23	-10174
PTCD3	-10147
MT-RNR1	-10092
MRPL20	-10074
MRPL36	-10006
MRPL27	-9973
MRPS15	-9872
MRPL11	-9799
MRPL32	-9751
MRPS11	-9725
MRPS6	-9723
MRPL17	-9672
MRPS24	-9647
MRPL12	-9477
GADD45GIP1	-9364
MRPL33	-9359
MRPS25	-9284
MRPL55	-9264
MRPL57	-9152
MRPL9	-9085
MRPS7	-8981
MRPL40	-8940
MRPL34	-8768
MRPS18B	-8747
MRPS9	-8725
MRPL28	-8723
MRPL44	-8722
MRPS16	-8713
MRPS31	-8684
MRPL47	-8527
MRPL46	-8364
MRPS34	-8321
TSFM	-8315
MRPL24	-8302
MRPS18A	-8293
MRPL14	-8229
TUFM	-8151
MRPS18C	-8095
MRPS26	-8071
MRPS33	-7959
MRPL18	-7909
MRPS17	-7743
MRPL39	-7714
MRPL16	-7623
AURKAIP1	-7274
MRPL22	-7116
GFM2	-7113
MRPL13	-7064
MRPS2	-7005
MRPL35	-6642
MRPL41	-6618
MRPS23	-6496
MRPS27	-5917
MRPL43	-5868
MRPS14	-5772
MRPL38	-5605
MRPL4	-5546
MRPS36	-5283
MRPL1	-5205
MRPL21	-5156
MRPL2	-4972
ERAL1	-4390
MRPL3	-3984
MTFMT	-3487
MRPL42	-3001
MRPS35	-2623
MRPL10	-2545
MRPL30	-1749
MRPL49	-375
MRPL19	1168
MRPS10	1777
MRPS30	3676
MRPL50	4514
MTRF1L	6873
GFM1	7225

---

Signaling by RNF43 mutants

set	Signaling by RNF43 mutants
setSize	7
pANOVA	0.0023
s.dist	0.665
p.adjustANOVA	0.0148

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FZD6	10011
LRP5	9937
FZD8	9905
FZD4	9418
FZD5	9354
RNF43	3872
LRP6	-2221

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FZD6	10011
LRP5	9937
FZD8	9905
FZD4	9418
FZD5	9354
RNF43	3872
LRP6	-2221

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	114
pANOVA	2.12e-34
s.dist	-0.662
p.adjustANOVA	2.05e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
UPF3A	-9722
MAGOH	-9715
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
UPF3B	-9137
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
SMG9	-8446
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
NCBP2	-7786
RPS29	-7614
MAGOHB	-7209
RPL28	-6783
RPS28	-6717
EIF4A3	-6215
RPS16	-6184
PPP2R2A	-5716
PNRC2	-5496
UPF2	-5313
RPL36AL	-4737
PPP2R1A	-4716
PPP2CA	-3841
DCP1A	-3831
RPL3L	-3474
NCBP1	-1375
RPL9	-823
RNPS1	523
ETF1	2451
SMG8	2819
RBM8A	2869
SMG6	2936
GSPT2	4986
UPF1	5843
SMG5	5904
SMG1	8040
GSPT1	8226
CASC3	8646
RPS26	8715
SMG7	8762
EIF4G1	9921

---

Nonsense-Mediated Decay (NMD)

set	Nonsense-Mediated Decay (NMD)
setSize	114
pANOVA	2.12e-34
s.dist	-0.662
p.adjustANOVA	2.05e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
UPF3A	-9722
MAGOH	-9715
RPS27	-9692
RPSA	-9646
RPL3	-9556
RPL18A	-9497
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
RPL13	-9291
RPL41	-9239
RPS4X	-9201
UPF3B	-9137
RPS21	-8961
RPLP0	-8912
RPLP1	-8829
RPS5	-8804
RPL37	-8489
RPS15	-8480
SMG9	-8446
RPS14	-8304
RPL36	-8221
RPS2	-8218
RPS27L	-8084
RPS4Y1	-7931
NCBP2	-7786
RPS29	-7614
MAGOHB	-7209
RPL28	-6783
RPS28	-6717
EIF4A3	-6215
RPS16	-6184
PPP2R2A	-5716
PNRC2	-5496
UPF2	-5313
RPL36AL	-4737
PPP2R1A	-4716
PPP2CA	-3841
DCP1A	-3831
RPL3L	-3474
NCBP1	-1375
RPL9	-823
RNPS1	523
ETF1	2451
SMG8	2819
RBM8A	2869
SMG6	2936
GSPT2	4986
UPF1	5843
SMG5	5904
SMG1	8040
GSPT1	8226
CASC3	8646
RPS26	8715
SMG7	8762
EIF4G1	9921

---

Regulation of expression of SLITs and ROBOs

set	Regulation of expression of SLITs and ROBOs
setSize	149
pANOVA	4.07e-44
s.dist	-0.66
p.adjustANOVA	8.73e-42

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
PSMB1	-11013
RPS24	-11010
RPS15A	-10987
RPL7	-10977
UBC	-10976
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL34	-11053
RPL27A	-11045
RPS3A	-11038
RPS13	-11023
RPL21	-11016
PSMB1	-11013
RPS24	-11010
RPS15A	-10987
RPL7	-10977
UBC	-10976
RPL5	-10975
RPL26	-10951
RPS8	-10939
RPL23	-10908
RPS20	-10873
RPL24	-10862
RPS7	-10812
RPL17	-10784
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
PSMB4	-10750
RPS25	-10741
RPL6	-10725
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
RPL27	-10688
RBX1	-10679
RPL29	-10669
RPL12	-10659
RPL7A	-10638
RPL19	-10580
RPS6	-10552
RPL23A	-10525
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
RPL22	-10448
RPS9	-10306
RPS3	-10263
RPL10A	-10204
RPL37A	-10177
RPS18	-10158
RPS17	-10118
PSMD13	-10087
PSMA5	-10054
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
FAU	-9985
RPL13A	-9961
RPL39	-9954
UBA52	-9927
RPL8	-9862
RPL15	-9812
RPL38	-9802
RPLP2	-9736
UPF3A	-9722
MAGOH	-9715
RPS27	-9692
RPSA	-9646
PSMA6	-9608
PSMD7	-9605
RPL3	-9556
RPL18A	-9497
PSMD8	-9485
PSMA4	-9456
RPS19	-9394
PABPC1	-9362
RPL35	-9342
RPS11	-9331
ELOC	-9319
RPL13	-9291
RPL41	-9239
RPS4X	-9201
UPF3B	-9137
PSMA1	-9120
RPS21	-8961
RPLP0	-8912
PSMB7	-8894
RPLP1	-8829
RPS5	-8804
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
RPL37	-8489
RPS15	-8480
PSMB3	-8478
PSMB6	-8441
RPS14	-8304
PSMD6	-8281
RPL36	-8221
RPS2	-8218
ELOB	-8190
RPS27L	-8084
PSMA2	-8048
PSMC3	-8023
SEM1	-7960
RPS4Y1	-7931
PSMB2	-7796
NCBP2	-7786
RPS29	-7614
PSMB5	-7557
PSMA7	-7539
PSMC4	-7492
MAGOHB	-7209
PSMD14	-6932
RPL28	-6783
CUL2	-6750
RPS28	-6717
EIF4A3	-6215
ROBO3	-6207
RPS16	-6184
UBB	-6070
PSMA3	-5797
UPF2	-5313
RPL36AL	-4737
RPL3L	-3474
PSMD2	-3341
LDB1	-2991
PSMC2	-2794
ADRM1	-2566
PSMD12	-2201
PSMD3	-1534
NCBP1	-1375
SLIT1	-888
RPL9	-823
LHX4	78
PSMD1	125
RNPS1	523
USP33	625
ETF1	2451
RBM8A	2869
GSPT2	4986
PSMD11	5261
ROBO1	6351
ZSWIM8	8085
GSPT1	8226
CASC3	8646
RPS26	8715
COL4A5	9539
EIF4G1	9921
DAG1	10131

---

Formation of xylulose-5-phosphate

set	Formation of xylulose-5-phosphate
setSize	5
pANOVA	0.0109
s.dist	-0.657
p.adjustANOVA	0.0478

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DCXR	-10653
AKR1A1	-10572
CRYL1	-7999
XYLB	-6581
SORD	-1005

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DCXR	-10653
AKR1A1	-10572
CRYL1	-7999
XYLB	-6581
SORD	-1005

---

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

set	Beta oxidation of hexanoyl-CoA to butanoyl-CoA
setSize	5
pANOVA	0.0111
s.dist	-0.656
p.adjustANOVA	0.0478

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ECHS1	-10900
HADH	-8797
ACADS	-7220
HADHA	-6510
HADHB	-3315

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ECHS1	-10900
HADH	-8797
ACADS	-7220
HADHA	-6510
HADHB	-3315

---

Post-transcriptional silencing by small RNAs

set	Post-transcriptional silencing by small RNAs
setSize	7
pANOVA	0.00271
s.dist	0.654
p.adjustANOVA	0.0168

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNRC6C	10316
AGO2	9070
TNRC6B	8997
AGO1	7709
TNRC6A	4732
AGO4	4660
AGO3	3953

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNRC6C	10316
AGO2	9070
TNRC6B	8997
AGO1	7709
TNRC6A	4732
AGO4	4660
AGO3	3953

---

Defective GALNT12 causes CRCS1

set	Defective GALNT12 causes CRCS1
setSize	9
pANOVA	0.000742
s.dist	0.649
p.adjustANOVA	0.0056

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MUC5B	10396
MUC12	10252
MUC16	10196
MUC4	9700
MUC1	9450
MUC20	6292
MUC6	6093
GALNT12	1148
MUCL1	-472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MUC5B	10396
MUC12	10252
MUC16	10196
MUC4	9700
MUC1	9450
MUC20	6292
MUC6	6093
GALNT12	1148
MUCL1	-472

---

Vpu mediated degradation of CD4

set	Vpu mediated degradation of CD4
setSize	39
pANOVA	2.59e-12
s.dist	-0.647
p.adjustANOVA	9.1e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
CD4	-10839
PSMB4	-10750
SKP1	-10724
RPS27A	-10695
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
CD4	-10839
PSMB4	-10750
SKP1	-10724
RPS27A	-10695
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441
PSMD6	-8281
PSMA2	-8048
PSMC3	-8023
SEM1	-7960
PSMB2	-7796
PSMB5	-7557
PSMA7	-7539
PSMC4	-7492
PSMD14	-6932
UBB	-6070
PSMA3	-5797
PSMD2	-3341
PSMC2	-2794
ADRM1	-2566
PSMD12	-2201
PSMD3	-1534
PSMD1	125
BTRC	176
PSMD11	5261

---

YAP1- and WWTR1 (TAZ)-stimulated gene expression

set	YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize	7
pANOVA	0.00335
s.dist	0.64
p.adjustANOVA	0.02

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HIPK2	10795
WWTR1	10186
KAT2B	10139
HIPK1	8828
RUNX2	5193
NPPA	3419
TEAD2	-208

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HIPK2	10795
WWTR1	10186
KAT2B	10139
HIPK1	8828
RUNX2	5193
NPPA	3419
TEAD2	-208

---

Recycling of eIF2:GDP

set	Recycling of eIF2:GDP
setSize	8
pANOVA	0.00199
s.dist	-0.631
p.adjustANOVA	0.0133

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF2B1	-10881
EIF2B2	-10589
EIF2S2	-9450
EIF2B4	-7368
EIF2B3	-7034
EIF2S3	-6914
EIF2B5	-6644
EIF2S1	2301

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF2B1	-10881
EIF2B2	-10589
EIF2S2	-9450
EIF2B4	-7368
EIF2B3	-7034
EIF2S3	-6914
EIF2B5	-6644
EIF2S1	2301

---

Vif-mediated degradation of APOBEC3G

set	Vif-mediated degradation of APOBEC3G
setSize	41
pANOVA	3.43e-12
s.dist	-0.628
p.adjustANOVA	1.18e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
PSMB4	-10750
RPS27A	-10695
RBX1	-10679
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
ELOC	-9319
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
PSMB4	-10750
RPS27A	-10695
RBX1	-10679
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
ELOC	-9319
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441
PSMD6	-8281
ELOB	-8190
PSMA2	-8048
PSMC3	-8023
SEM1	-7960
PSMB2	-7796
PSMB5	-7557
PSMA7	-7539
PSMC4	-7492
PSMD14	-6932
UBB	-6070
PSMA3	-5797
PSMD2	-3341
PSMC2	-2794
ADRM1	-2566
PSMD12	-2201
PSMD3	-1534
APOBEC3G	-1420
PSMD1	125
CUL5	2551
PSMD11	5261

---

Modulation by Mtb of host immune system

set	Modulation by Mtb of host immune system
setSize	7
pANOVA	0.00408
s.dist	-0.627
p.adjustANOVA	0.0234

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBC	-10976
RPS27A	-10695
B2M	-10170
UBA52	-9927
UBB	-6070
TLR2	-1849
MRC1	506

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBC	-10976
RPS27A	-10695
B2M	-10170
UBA52	-9927
UBB	-6070
TLR2	-1849
MRC1	506

---

Physiological factors

set	Physiological factors
setSize	9
pANOVA	0.00121
s.dist	0.623
p.adjustANOVA	0.00865

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HIPK2	10795
WWTR1	10186
MME	10178
KAT2B	10139
CES1	9702
HIPK1	8828
NPPA	3419
CORIN	3117
NPR2	-5930

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HIPK2	10795
WWTR1	10186
MME	10178
KAT2B	10139
CES1	9702
HIPK1	8828
NPPA	3419
CORIN	3117
NPR2	-5930

---

Translation

set	Translation
setSize	293
pANOVA	9.48e-75
s.dist	-0.619
p.adjustANOVA	1.83e-71

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS28	-11079
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
EIF4EBP1	-11041
RPS3A	-11038
MTIF3	-11037
MRPL52	-11031
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
MRPL37	-10968
OXA1L	-10961
RPL26	-10951
RPS8	-10939
DAP3	-10920
RPL23	-10908

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS28	-11079
EIF3M	-11063
RPL34	-11053
RPL27A	-11045
EIF4EBP1	-11041
RPS3A	-11038
MTIF3	-11037
MRPL52	-11031
RPS13	-11023
RPL21	-11016
RPS24	-11010
RPS15A	-10987
RPL7	-10977
RPL5	-10975
MRPL37	-10968
OXA1L	-10961
RPL26	-10951
RPS8	-10939
DAP3	-10920
RPL23	-10908
EIF2B1	-10881
RPS20	-10873
RPL24	-10862
EIF4A1	-10861
EEF1B2	-10852
RPS7	-10812
MRRF	-10804
RPL17	-10784
SEC11A	-10769
RPL36A	-10764
RPL14	-10763
RPL35A	-10753
RPS25	-10741
RPL6	-10725
MTIF2	-10718
RPL26L1	-10707
RPL4	-10699
RPS27A	-10695
MRPL15	-10691
RPL27	-10688
RPL29	-10669
EIF3H	-10666
RPL12	-10659
MRPS22	-10639
RPL7A	-10638
EIF3K	-10630
MRPL54	-10610
AIMP1	-10596
EIF2B2	-10589
RPL19	-10580
RPS6	-10552
CHCHD1	-10547
RPL23A	-10525
SSR2	-10510
RPS12	-10504
RPL30	-10503
RPL39L	-10471
RPL18	-10470
RPL31	-10468
RPL11	-10466
RPS10	-10459
RPL10	-10457
MRPL45	-10451
RPL22	-10448
MRPL58	-10423
SPCS1	-10349
MRPS21	-10319
MRPL53	-10314
RPS9	-10306
MT-RNR2	-10295
MRPS5	-10281
MRPL48	-10275
RPS3	-10263
EEF1A1	-10262
MRPL51	-10240
RPL10A	-10204
RPL37A	-10177
MRPL23	-10174
RPS18	-10158
PTCD3	-10147
EIF3E	-10127
RPS17	-10118
MT-RNR1	-10092
SRP14	-10084
MRPL20	-10074
EIF3D	-10064
RPS23	-10051
RPL22L1	-10017
RPL32	-10010
MRPL36	-10006
FAU	-9985
TRMT112	-9981
MRPL27	-9973
RPL13A	-9961
RPL39	-9954
UBA52	-9927
EEF1G	-9914
MRPS15	-9872
EIF3I	-9868
RPL8	-9862
RPL15	-9812
RPL38	-9802
EIF5	-9800
MRPL11	-9799
MRPL32	-9751
RPLP2	-9736
MRPS11	-9725
MRPS6	-9723
RPS27	-9692
MRPL17	-9672
MRPS24	-9647
RPSA	-9646
EIF3L	-9571
RPL3	-9556
PPA1	-9555
RARS1	-9534
RPL18A	-9497
MRPL12	-9477
EIF2S2	-9450
KARS1	-9395
RPS19	-9394
GADD45GIP1	-9364
PABPC1	-9362
MRPL33	-9359
RPL35	-9342
RPS11	-9331
SEC61G	-9329
DARS1	-9320
RPL13	-9291
MRPS25	-9284
MRPL55	-9264
RPL41	-9239
RPS4X	-9201
MRPL57	-9152
MRPL9	-9085
EIF3G	-9071
SRP9	-9022
MRPS7	-8981
RPS21	-8961
MRPL40	-8940
QARS1	-8925
RPLP0	-8912
EEF1D	-8856
EEF1E1	-8846
RPLP1	-8829
RPS5	-8804
MRPL34	-8768
MRPS18B	-8747
MRPS9	-8725
MRPL28	-8723
MRPL44	-8722
MRPS16	-8713
MRPS31	-8684
MRPL47	-8527
NARS1	-8502
RPL37	-8489
RPS15	-8480
MRPL46	-8364
EIF4A2	-8347
MRPS34	-8321
TSFM	-8315
RPS14	-8304
MRPL24	-8302
MRPS18A	-8293
EIF3C	-8255
EIF3J	-8236
MRPL14	-8229
RPN2	-8225
RPL36	-8221
RPS2	-8218
TUFM	-8151
MRPS18C	-8095
RPS27L	-8084
MRPS26	-8071
MRPS33	-7959
RPS4Y1	-7931
MRPL18	-7909
FARSB	-7795
MRPS17	-7743
SARS1	-7729
MRPL39	-7714
MRPL16	-7623
RPS29	-7614
PPA2	-7464
EIF2B4	-7368
SSR4	-7309
AURKAIP1	-7274
MRPL22	-7116
GFM2	-7113
SSR3	-7099
MRPL13	-7064
EIF2B3	-7034
MRPS2	-7005
EIF2S3	-6914
WARS2	-6860
EIF3F	-6839
RPL28	-6783
APEH	-6755
RPS28	-6717
EIF2B5	-6644
MRPL35	-6642
MRPL41	-6618
SEC61B	-6546
MRPS23	-6496
EIF3B	-6495
EEF1A1P5	-6220
RPS16	-6184
EIF4H	-6015
SEC11C	-5972
FARS2	-5966
MRPS27	-5917
MRPL43	-5868
RPN1	-5820
MRPS14	-5772
EIF3A	-5685
MRPL38	-5605
TARS2	-5577
MRPL4	-5546
GARS1	-5540
EIF5B	-5523
EIF1AX	-5427
CARS1	-5401
MRPS36	-5283
MRPL1	-5205
MRPL21	-5156
SRP19	-5124
MRPL2	-4972
SRP68	-4767
RPL36AL	-4737
DDOST	-4676
SEC61A2	-4650
SARS2	-4546
HARS2	-4480
ERAL1	-4390
SRPRB	-4374
HARS1	-4235
AIMP2	-4220
SRP72	-4161
MRPL3	-3984
RARS2	-3832
MTFMT	-3487
RPL3L	-3474
YARS1	-3301
MRPL42	-3001
YARS2	-2838
EIF4B	-2836
EEF2	-2762
MARS1	-2689
IARS2	-2632
MRPS35	-2623
MRPL10	-2545
EEF1A2	-2354
SPCS2	-1848
MRPL30	-1749
CARS2	-1668
EIF4E	-1272
FARSA	-1191
RPL9	-823
MRPL49	-375
AARS2	80
TRAM1	150
LARS1	293
EPRS1	593
MRPL19	1168
AARS1	1413
MRPS10	1777
SRP54	2009
SSR1	2287
EIF2S1	2301
ETF1	2451
SPCS3	2874
SEC61A1	3378
MRPS30	3676
N6AMT1	3707
VARS1	3793
VARS2	4336
WARS1	4406
MRPL50	4514
GSPT2	4986
EARS2	5263
SRPRA	5695
PARS2	5792
TARS1	6202
MTRF1L	6873
GFM1	7225
IARS1	8116
MARS2	8179
GSPT1	8226
NARS2	8596
RPS26	8715
DARS2	8888
LARS2	9916
EIF4G1	9921

---

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

set	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize	39
pANOVA	2.24e-11
s.dist	-0.619
p.adjustANOVA	6.55e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
PSMB4	-10750
RPS27A	-10695
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441
PSMD6	-8281
PSMA2	-8048

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
PSMB4	-10750
RPS27A	-10695
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441
PSMD6	-8281
PSMA2	-8048
PSMC3	-8023
SEM1	-7960
PSMB2	-7796
CHEK1	-7683
PSMB5	-7557
PSMA7	-7539
PSMC4	-7492
PSMD14	-6932
CHEK2	-6884
UBB	-6070
PSMA3	-5797
PSMD2	-3341
PSMC2	-2794
ADRM1	-2566
PSMD12	-2201
PSMD3	-1534
PSMD1	125
PSMD11	5261
CDC25A	5399

---

p53-Independent DNA Damage Response

set	p53-Independent DNA Damage Response
setSize	39
pANOVA	2.24e-11
s.dist	-0.619
p.adjustANOVA	6.55e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
PSMB4	-10750
RPS27A	-10695
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441
PSMD6	-8281
PSMA2	-8048

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB1	-11013
UBC	-10976
PSMB4	-10750
RPS27A	-10695
PSMD13	-10087
PSMA5	-10054
UBA52	-9927
PSMA6	-9608
PSMD7	-9605
PSMD8	-9485
PSMA4	-9456
PSMA1	-9120
PSMB7	-8894
PSMC6	-8659
PSMC5	-8653
PSMC1	-8520
PSMB3	-8478
PSMB6	-8441
PSMD6	-8281
PSMA2	-8048
PSMC3	-8023
SEM1	-7960
PSMB2	-7796
CHEK1	-7683
PSMB5	-7557
PSMA7	-7539
PSMC4	-7492
PSMD14	-6932
CHEK2	-6884
UBB	-6070
PSMA3	-5797
PSMD2	-3341
PSMC2	-2794
ADRM1	-2566
PSMD12	-2201
PSMD3	-1534
PSMD1	125
PSMD11	5261
CDC25A	5399

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report