date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.0342206
A1BG -0.7880530
A1BG-AS1 -0.2972136
A1CF 0.2853810
A2M 1.2471435
A2M-AS1 1.4413708

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21253
duplicated_genes_present 0
num_profile_genes_in_sets 8700
num_profile_genes_not_in_sets 12553

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1198
num_genesets_included 1527

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
MET activates PI3K/AKT signaling 5 1.39e-03 0.825 0.008780
CD163 mediating an anti-inflammatory response 8 6.18e-05 0.818 0.000698
NFE2L2 regulates pentose phosphate pathway genes 8 1.50e-04 0.774 0.001370
Cohesin Loading onto Chromatin 10 3.09e-05 0.761 0.000420
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 2.29e-03 0.719 0.013200
Establishment of Sister Chromatid Cohesion 11 9.33e-05 0.680 0.000944
Scavenging by Class A Receptors 10 3.15e-04 0.658 0.002560
MET activates RAP1 and RAC1 10 3.16e-04 0.658 0.002560
RUNX1 regulates transcription of genes involved in BCR signaling 6 6.91e-03 0.637 0.032100
ATF6 (ATF6-alpha) activates chaperone genes 10 7.20e-04 0.618 0.004980
Gain-of-function MRAS complexes activate RAF signaling 8 2.87e-03 0.609 0.015800
SHOC2 M1731 mutant abolishes MRAS complex function 8 2.87e-03 0.609 0.015800
Signaling by MRAS-complex mutants 8 2.87e-03 0.609 0.015800
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 5.38e-03 -0.607 0.026000
Sulfide oxidation to sulfate 5 1.92e-02 -0.605 0.071400
Relaxin receptors 5 2.07e-02 0.598 0.076100
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.33e-04 0.595 0.004460
STAT5 activation downstream of FLT3 ITD mutants 9 2.01e-03 0.594 0.012000
Cross-presentation of particulate exogenous antigens (phagosomes) 8 3.78e-03 0.591 0.019600
Erythrocytes take up oxygen and release carbon dioxide 7 6.84e-03 0.590 0.031900
Wax and plasmalogen biosynthesis 5 2.41e-02 0.582 0.084500
Eicosanoids 6 1.36e-02 0.582 0.054100
Regulation of gene expression by Hypoxia-inducible Factor 8 4.59e-03 0.579 0.022700
Inhibition of Signaling by Overexpressed EGFR 5 2.57e-02 0.576 0.087900
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 2.57e-02 0.576 0.087900
Signaling by FLT3 ITD and TKD mutants 15 1.39e-04 0.568 0.001290
Platelet sensitization by LDL 16 8.90e-05 0.566 0.000919
EGFR Transactivation by Gastrin 7 9.74e-03 0.564 0.041900
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 1.04e-02 0.559 0.044300
FBXW7 Mutants and NOTCH1 in Cancer 5 3.06e-02 0.558 0.098700
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 3.06e-02 0.558 0.098700
Mitotic Telophase/Cytokinesis 13 4.96e-04 0.558 0.003610
Regulation of IFNG signaling 14 3.03e-04 0.558 0.002500
PI-3K cascade:FGFR3 10 3.10e-03 0.540 0.016700
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 2.34e-02 -0.534 0.082500
GAB1 signalosome 14 5.80e-04 0.531 0.004190
Response to metal ions 6 2.47e-02 0.529 0.085500
Maturation of hRSV A proteins 13 1.03e-03 0.526 0.006820
Displacement of DNA glycosylase by APEX1 9 6.43e-03 -0.525 0.030400
ARMS-mediated activation 6 2.64e-02 0.524 0.089600
Organic cation transport 8 1.04e-02 0.523 0.044200
Organic cation/anion/zwitterion transport 8 1.04e-02 0.523 0.044200
GRB2 events in EGFR signaling 10 4.91e-03 0.514 0.023900
RHOT1 GTPase cycle 5 4.67e-02 0.514 0.135000
Uptake and function of diphtheria toxin 6 3.02e-02 0.511 0.098100
Scavenging by Class F Receptors 5 4.83e-02 0.510 0.138000
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 4.32e-04 0.508 0.003220
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 4.76e-04 0.504 0.003500
SOS-mediated signalling 7 2.09e-02 0.504 0.076800
POLB-Dependent Long Patch Base Excision Repair 8 1.36e-02 -0.504 0.054100


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
MET activates PI3K/AKT signaling 5 1.39e-03 0.825000 8.78e-03
CD163 mediating an anti-inflammatory response 8 6.18e-05 0.818000 6.98e-04
NFE2L2 regulates pentose phosphate pathway genes 8 1.50e-04 0.774000 1.37e-03
Cohesin Loading onto Chromatin 10 3.09e-05 0.761000 4.20e-04
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 2.29e-03 0.719000 1.32e-02
Establishment of Sister Chromatid Cohesion 11 9.33e-05 0.680000 9.44e-04
Scavenging by Class A Receptors 10 3.15e-04 0.658000 2.56e-03
MET activates RAP1 and RAC1 10 3.16e-04 0.658000 2.56e-03
RUNX1 regulates transcription of genes involved in BCR signaling 6 6.91e-03 0.637000 3.21e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 7.20e-04 0.618000 4.98e-03
Gain-of-function MRAS complexes activate RAF signaling 8 2.87e-03 0.609000 1.58e-02
SHOC2 M1731 mutant abolishes MRAS complex function 8 2.87e-03 0.609000 1.58e-02
Signaling by MRAS-complex mutants 8 2.87e-03 0.609000 1.58e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 5.38e-03 -0.607000 2.60e-02
Sulfide oxidation to sulfate 5 1.92e-02 -0.605000 7.14e-02
Relaxin receptors 5 2.07e-02 0.598000 7.61e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.33e-04 0.595000 4.46e-03
STAT5 activation downstream of FLT3 ITD mutants 9 2.01e-03 0.594000 1.20e-02
Cross-presentation of particulate exogenous antigens (phagosomes) 8 3.78e-03 0.591000 1.96e-02
Erythrocytes take up oxygen and release carbon dioxide 7 6.84e-03 0.590000 3.19e-02
Wax and plasmalogen biosynthesis 5 2.41e-02 0.582000 8.45e-02
Eicosanoids 6 1.36e-02 0.582000 5.41e-02
Regulation of gene expression by Hypoxia-inducible Factor 8 4.59e-03 0.579000 2.27e-02
Inhibition of Signaling by Overexpressed EGFR 5 2.57e-02 0.576000 8.79e-02
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 2.57e-02 0.576000 8.79e-02
Signaling by FLT3 ITD and TKD mutants 15 1.39e-04 0.568000 1.29e-03
Platelet sensitization by LDL 16 8.90e-05 0.566000 9.19e-04
EGFR Transactivation by Gastrin 7 9.74e-03 0.564000 4.19e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 1.04e-02 0.559000 4.43e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 3.06e-02 0.558000 9.87e-02
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 3.06e-02 0.558000 9.87e-02
Mitotic Telophase/Cytokinesis 13 4.96e-04 0.558000 3.61e-03
Regulation of IFNG signaling 14 3.03e-04 0.558000 2.50e-03
PI-3K cascade:FGFR3 10 3.10e-03 0.540000 1.67e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 2.34e-02 -0.534000 8.25e-02
GAB1 signalosome 14 5.80e-04 0.531000 4.19e-03
Response to metal ions 6 2.47e-02 0.529000 8.55e-02
Maturation of hRSV A proteins 13 1.03e-03 0.526000 6.82e-03
Displacement of DNA glycosylase by APEX1 9 6.43e-03 -0.525000 3.04e-02
ARMS-mediated activation 6 2.64e-02 0.524000 8.96e-02
Organic cation transport 8 1.04e-02 0.523000 4.42e-02
Organic cation/anion/zwitterion transport 8 1.04e-02 0.523000 4.42e-02
GRB2 events in EGFR signaling 10 4.91e-03 0.514000 2.39e-02
RHOT1 GTPase cycle 5 4.67e-02 0.514000 1.35e-01
Uptake and function of diphtheria toxin 6 3.02e-02 0.511000 9.81e-02
Scavenging by Class F Receptors 5 4.83e-02 0.510000 1.38e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 4.32e-04 0.508000 3.22e-03
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 4.76e-04 0.504000 3.50e-03
SOS-mediated signalling 7 2.09e-02 0.504000 7.68e-02
POLB-Dependent Long Patch Base Excision Repair 8 1.36e-02 -0.504000 5.41e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.86e-03 0.498000 1.13e-02
Organic anion transporters 7 2.32e-02 -0.495000 8.24e-02
Butyrophilin (BTN) family interactions 10 6.68e-03 -0.495000 3.12e-02
Phenylalanine metabolism 5 5.54e-02 -0.495000 1.53e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 5.55e-02 -0.494000 1.53e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 6.20e-04 0.494000 4.41e-03
Translocation of ZAP-70 to Immunological synapse 24 2.80e-05 -0.494000 3.89e-04
Signal attenuation 9 1.03e-02 0.494000 4.42e-02
APOBEC3G mediated resistance to HIV-1 infection 5 5.62e-02 -0.493000 1.54e-01
Signaling by FLT3 fusion proteins 18 3.26e-04 0.489000 2.62e-03
Signaling by Leptin 10 7.38e-03 0.489000 3.38e-02
RUNX1 regulates expression of components of tight junctions 5 5.99e-02 0.486000 1.61e-01
ATF6 (ATF6-alpha) activates chaperones 12 3.64e-03 0.485000 1.90e-02
Lysosphingolipid and LPA receptors 11 5.70e-03 -0.481000 2.74e-02
Synthesis of diphthamide-EEF2 8 1.91e-02 -0.478000 7.13e-02
RHO GTPases Activate WASPs and WAVEs 35 1.19e-06 0.474000 3.63e-05
Dissolution of Fibrin Clot 12 4.55e-03 0.473000 2.25e-02
Protein repair 6 4.64e-02 0.470000 1.35e-01
Erythrocytes take up carbon dioxide and release oxygen 11 7.42e-03 0.466000 3.38e-02
O2/CO2 exchange in erythrocytes 11 7.42e-03 0.466000 3.38e-02
RHO GTPases activate KTN1 11 7.59e-03 0.465000 3.45e-02
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 7.19e-02 0.465000 1.82e-01
rRNA modification in the mitochondrion 8 2.29e-02 -0.465000 8.15e-02
Fructose metabolism 7 3.37e-02 -0.463000 1.06e-01
Axonal growth inhibition (RHOA activation) 7 3.52e-02 0.460000 1.09e-01
p75NTR regulates axonogenesis 7 3.52e-02 0.460000 1.09e-01
Insulin receptor recycling 24 1.11e-04 0.456000 1.07e-03
Role of ABL in ROBO-SLIT signaling 6 5.38e-02 0.455000 1.50e-01
Signaling by LTK in cancer 7 3.73e-02 0.455000 1.13e-01
SHC1 events in EGFR signaling 11 9.46e-03 0.452000 4.14e-02
Formation of the active cofactor, UDP-glucuronate 5 8.16e-02 0.450000 1.99e-01
Negative regulation of MET activity 18 1.04e-03 0.446000 6.87e-03
PI3K/AKT activation 8 2.97e-02 0.444000 9.70e-02
IFNG signaling activates MAPKs 8 2.99e-02 0.443000 9.73e-02
Cross-presentation of soluble exogenous antigens (endosomes) 35 5.66e-06 0.443000 1.16e-04
Activated NTRK2 signals through FRS2 and FRS3 8 3.02e-02 0.442000 9.81e-02
Nucleotide biosynthesis 12 8.19e-03 -0.441000 3.67e-02
Platelet Adhesion to exposed collagen 14 4.37e-03 0.440000 2.19e-02
RHO GTPases Activate ROCKs 18 1.32e-03 0.437000 8.42e-03
Digestion 5 9.10e-02 0.436000 2.15e-01
Trafficking of GluR2-containing AMPA receptors 11 1.26e-02 0.434000 5.15e-02
Fructose catabolism 5 9.31e-02 -0.434000 2.18e-01
TNFR1-mediated ceramide production 6 6.68e-02 -0.432000 1.73e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 1.32e-06 0.431000 3.91e-05
Signaling by PDGFR in disease 19 1.14e-03 0.431000 7.38e-03
RHOBTB1 GTPase cycle 23 3.49e-04 0.431000 2.76e-03
Androgen biosynthesis 5 9.78e-02 0.428000 2.26e-01
Purine ribonucleoside monophosphate biosynthesis 9 2.71e-02 -0.425000 9.13e-02
ALK mutants bind TKIs 11 1.47e-02 0.425000 5.80e-02
Ethanol oxidation 6 7.36e-02 -0.422000 1.85e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 4.72e-03 0.421000 2.32e-02
Uptake and function of anthrax toxins 10 2.25e-02 0.417000 8.11e-02
Synthesis of 12-eicosatetraenoic acid derivatives 6 7.81e-02 -0.415000 1.92e-01
Resolution of Abasic Sites (AP sites) 38 9.90e-06 -0.414000 1.71e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 1.34e-05 0.413000 2.21e-04
PI-3K cascade:FGFR4 11 1.80e-02 0.412000 6.77e-02
Regulation of Apoptosis 40 6.58e-06 0.412000 1.26e-04
Signaling by cytosolic FGFR1 fusion mutants 18 2.51e-03 0.411000 1.42e-02
Reversible hydration of carbon dioxide 8 4.39e-02 0.411000 1.30e-01
Activation of NOXA and translocation to mitochondria 5 1.11e-01 -0.411000 2.47e-01
Activation of NF-kappaB in B cells 54 1.71e-07 0.411000 8.20e-06
Degradation of GLI2 by the proteasome 45 1.82e-06 0.411000 4.99e-05
GLI3 is processed to GLI3R by the proteasome 45 1.82e-06 0.411000 4.99e-05
Signaling by Erythropoietin 24 4.96e-04 0.411000 3.61e-03
Nuclear events mediated by NFE2L2 81 2.13e-10 0.408000 1.95e-08
EGFR downregulation 26 3.16e-04 0.408000 2.56e-03
RHO GTPases activate IQGAPs 25 4.22e-04 0.407000 3.18e-03
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 8.42e-02 0.407000 2.02e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.15e-02 0.405000 4.81e-02
Smooth Muscle Contraction 34 4.41e-05 0.405000 5.40e-04
CHL1 interactions 8 4.79e-02 0.404000 1.38e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 2.35e-03 0.403000 1.35e-02
Hh mutants are degraded by ERAD 42 6.55e-06 0.402000 1.26e-04
RHO GTPases Activate NADPH Oxidases 21 1.44e-03 0.402000 9.02e-03
Regulation of HMOX1 expression and activity 5 1.20e-01 0.402000 2.60e-01
Alpha-protein kinase 1 signaling pathway 11 2.13e-02 0.401000 7.81e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 1.69e-06 0.399000 4.76e-05
Defective CFTR causes cystic fibrosis 47 2.20e-06 0.399000 5.64e-05
Regulation of ornithine decarboxylase (ODC) 38 2.10e-05 0.399000 3.11e-04
Degradation of GLI1 by the proteasome 46 3.10e-06 0.397000 7.63e-05
PTK6 promotes HIF1A stabilization 6 9.25e-02 0.397000 2.18e-01
RHO GTPases activate PAKs 20 2.31e-03 0.394000 1.33e-02
MAPK1 (ERK2) activation 8 5.48e-02 0.392000 1.52e-01
activated TAK1 mediates p38 MAPK activation 23 1.24e-03 0.389000 7.96e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 1.29e-05 0.389000 2.14e-04
Prolonged ERK activation events 13 1.53e-02 0.388000 5.99e-02
Biotin transport and metabolism 11 2.59e-02 -0.388000 8.83e-02
Negative regulation of NOTCH4 signaling 44 8.52e-06 0.388000 1.52e-04
DNA replication initiation 8 5.76e-02 -0.388000 1.56e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 2.03e-02 0.387000 7.50e-02
IRAK4 deficiency (TLR2/4) 15 9.49e-03 0.387000 4.14e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 4.52e-02 -0.386000 1.32e-01
Formation of the nephric duct 8 5.94e-02 0.385000 1.61e-01
Inactivation of CDC42 and RAC1 7 7.80e-02 0.385000 1.92e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 7.74e-03 0.385000 3.50e-02
Regulation of TP53 Activity through Association with Co-factors 11 2.74e-02 -0.384000 9.20e-02
Hh mutants abrogate ligand secretion 43 1.39e-05 0.383000 2.26e-04
PD-1 signaling 28 4.53e-04 -0.383000 3.35e-03
EGFR interacts with phospholipase C-gamma 6 1.05e-01 0.382000 2.37e-01
Signaling by FGFR3 in disease 14 1.33e-02 0.382000 5.34e-02
Synthesis of PIPs at the late endosome membrane 11 2.85e-02 0.381000 9.41e-02
Defects in biotin (Btn) metabolism 8 6.22e-02 -0.381000 1.66e-01
Signaling by EGFR 47 6.34e-06 0.381000 1.26e-04
RHO GTPases activate PKNs 46 8.04e-06 0.380000 1.46e-04
Signaling by PDGFRA extracellular domain mutants 12 2.26e-02 0.380000 8.12e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.26e-02 0.380000 8.12e-02
Degradation of cysteine and homocysteine 12 2.27e-02 -0.380000 8.14e-02
Signal regulatory protein family interactions 13 1.81e-02 0.379000 6.78e-02
PI3K events in ERBB4 signaling 6 1.08e-01 0.379000 2.43e-01
Regulated proteolysis of p75NTR 11 2.98e-02 0.378000 9.73e-02
Vpu mediated degradation of CD4 39 4.36e-05 0.378000 5.37e-04
NFE2L2 regulating ER-stress associated genes 5 1.44e-01 0.377000 2.92e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 3.55e-03 0.377000 1.87e-02
Interleukin-6 signaling 10 3.95e-02 0.376000 1.19e-01
Fatty acids 6 1.12e-01 0.375000 2.48e-01
FGFR1b ligand binding and activation 5 1.47e-01 -0.375000 2.95e-01
Cargo concentration in the ER 31 3.08e-04 0.374000 2.53e-03
MAPK3 (ERK1) activation 9 5.18e-02 0.374000 1.45e-01
Insulin processing 19 4.73e-03 0.374000 2.32e-02
Hedgehog ligand biogenesis 47 9.08e-06 0.374000 1.59e-04
CTNNB1 S33 mutants aren’t phosphorylated 15 1.21e-02 0.374000 5.00e-02
CTNNB1 S37 mutants aren’t phosphorylated 15 1.21e-02 0.374000 5.00e-02
CTNNB1 S45 mutants aren’t phosphorylated 15 1.21e-02 0.374000 5.00e-02
CTNNB1 T41 mutants aren’t phosphorylated 15 1.21e-02 0.374000 5.00e-02
Signaling by CTNNB1 phospho-site mutants 15 1.21e-02 0.374000 5.00e-02
Signaling by GSK3beta mutants 15 1.21e-02 0.374000 5.00e-02
Metalloprotease DUBs 20 3.81e-03 0.374000 1.97e-02
MyD88 deficiency (TLR2/4) 14 1.59e-02 0.372000 6.15e-02
Biosynthesis of Lipoxins (LX) 6 1.15e-01 0.371000 2.53e-01
PI-3K cascade:FGFR2 13 2.06e-02 0.371000 7.60e-02
DARPP-32 events 22 2.72e-03 0.369000 1.51e-02
Erythropoietin activates Phospholipase C gamma (PLCG) 6 1.18e-01 0.369000 2.57e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 4.56e-05 0.368000 5.50e-04
Cellular hexose transport 14 1.73e-02 -0.368000 6.60e-02
Unwinding of DNA 12 2.76e-02 -0.367000 9.22e-02
CD22 mediated BCR regulation 58 1.31e-06 -0.367000 3.91e-05
STAT5 Activation 7 9.28e-02 0.367000 2.18e-01
Ubiquitin-dependent degradation of Cyclin D 39 7.39e-05 0.367000 8.16e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 7.73e-05 0.366000 8.33e-04
p53-Independent DNA Damage Response 39 7.73e-05 0.366000 8.33e-04
p53-Independent G1/S DNA damage checkpoint 39 7.73e-05 0.366000 8.33e-04
GPVI-mediated activation cascade 31 4.30e-04 0.365000 3.22e-03
RHOBTB GTPase Cycle 35 1.90e-04 0.365000 1.64e-03
Erythropoietin activates STAT5 6 1.23e-01 0.364000 2.65e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 1.88e-02 0.363000 7.02e-02
G2/M DNA replication checkpoint 5 1.62e-01 0.361000 3.18e-01
SCF-beta-TrCP mediated degradation of Emi1 42 5.21e-05 0.361000 6.10e-04
FLT3 signaling in disease 27 1.20e-03 0.360000 7.71e-03
GDP-fucose biosynthesis 6 1.28e-01 -0.359000 2.69e-01
Degradation of DVL 43 4.68e-05 0.359000 5.58e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.19e-02 0.358000 1.02e-01
COPI-independent Golgi-to-ER retrograde traffic 45 3.32e-05 0.358000 4.36e-04
Synthesis of UDP-N-acetyl-glucosamine 8 8.03e-02 -0.357000 1.96e-01
Signaling by Hippo 18 8.77e-03 0.357000 3.87e-02
Erythropoietin activates RAS 13 2.61e-02 0.356000 8.87e-02
Autodegradation of the E3 ubiquitin ligase COP1 38 1.43e-04 0.356000 1.33e-03
NPAS4 regulates expression of target genes 16 1.36e-02 0.356000 5.41e-02
Methionine salvage pathway 6 1.32e-01 -0.355000 2.74e-01
Somitogenesis 41 8.63e-05 0.354000 9.01e-04
Downstream signaling events of B Cell Receptor (BCR) 68 4.36e-07 0.354000 1.75e-05
FGFR1 mutant receptor activation 25 2.28e-03 0.352000 1.32e-02
FRS-mediated FGFR3 signaling 12 3.49e-02 0.352000 1.08e-01
Cytosolic iron-sulfur cluster assembly 13 2.82e-02 -0.352000 9.39e-02
Peptide chain elongation 88 1.19e-08 -0.351000 7.50e-07
Pentose phosphate pathway 13 2.85e-02 0.351000 9.41e-02
Dectin-1 mediated noncanonical NF-kB signaling 47 3.15e-05 0.351000 4.23e-04
SARS-CoV-1 modulates host translation machinery 36 2.71e-04 -0.351000 2.27e-03
Attenuation phase 22 4.41e-03 0.351000 2.20e-02
Vif-mediated degradation of APOBEC3G 41 1.04e-04 0.350000 1.02e-03
NIK–>noncanonical NF-kB signaling 46 4.07e-05 0.350000 5.07e-04
Downregulation of TGF-beta receptor signaling 26 2.07e-03 0.349000 1.22e-02
MET receptor recycling 9 7.02e-02 0.349000 1.79e-01
Cellular response to hypoxia 59 3.67e-06 0.348000 8.48e-05
Activated NTRK2 signals through RAS 6 1.40e-01 0.348000 2.87e-01
Activated NTRK3 signals through RAS 6 1.40e-01 0.348000 2.87e-01
Chaperone Mediated Autophagy 20 7.08e-03 0.348000 3.28e-02
APC truncation mutants have impaired AXIN binding 14 2.45e-02 0.347000 8.50e-02
AXIN missense mutants destabilize the destruction complex 14 2.45e-02 0.347000 8.50e-02
Signaling by AMER1 mutants 14 2.45e-02 0.347000 8.50e-02
Signaling by APC mutants 14 2.45e-02 0.347000 8.50e-02
Signaling by AXIN mutants 14 2.45e-02 0.347000 8.50e-02
Truncations of AMER1 destabilize the destruction complex 14 2.45e-02 0.347000 8.50e-02
Reduction of cytosolic Ca++ levels 9 7.14e-02 0.347000 1.81e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 3.03e-02 0.347000 9.81e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 3.27e-04 0.346000 2.62e-03
Signaling by FGFR4 in disease 11 4.72e-02 0.345000 1.36e-01
Degradation of AXIN 42 1.08e-04 0.345000 1.05e-03
Defective HLCS causes multiple carboxylase deficiency 7 1.14e-01 -0.345000 2.51e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 5.07e-06 0.343000 1.08e-04
KEAP1-NFE2L2 pathway 106 1.03e-09 0.343000 8.26e-08
MAPK6/MAPK4 signaling 69 8.59e-07 0.343000 2.85e-05
Nef and signal transduction 8 9.34e-02 0.343000 2.18e-01
Eukaryotic Translation Elongation 93 1.17e-08 -0.342000 7.50e-07
Netrin mediated repulsion signals 5 1.85e-01 0.342000 3.46e-01
Interleukin-1 signaling 99 4.13e-09 0.342000 3.06e-07
Frs2-mediated activation 11 4.98e-02 0.342000 1.41e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 3.12e-03 -0.342000 1.67e-02
Signaling by FGFR1 in disease 32 8.33e-04 0.341000 5.62e-03
Downstream signaling of activated FGFR3 17 1.49e-02 0.341000 5.86e-02
Signal transduction by L1 20 8.31e-03 0.341000 3.71e-02
Constitutive Signaling by EGFRvIII 14 2.75e-02 0.340000 9.20e-02
Signaling by EGFRvIII in Cancer 14 2.75e-02 0.340000 9.20e-02
Depolymerization of the Nuclear Lamina 15 2.26e-02 0.340000 8.12e-02
PDH complex synthesizes acetyl-CoA from PYR 5 1.88e-01 0.340000 3.49e-01
Presynaptic depolarization and calcium channel opening 8 9.61e-02 -0.340000 2.23e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 1.67e-04 0.340000 1.50e-03
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.20e-01 0.339000 2.60e-01
SCF(Skp2)-mediated degradation of p27/p21 50 3.39e-05 0.339000 4.44e-04
DAP12 interactions 39 2.61e-04 0.338000 2.20e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 2.52e-05 0.338000 3.61e-04
Abacavir ADME 5 1.91e-01 0.338000 3.54e-01
Proton-coupled monocarboxylate transport 6 1.53e-01 0.337000 3.04e-01
Synthesis of PIPs at the early endosome membrane 16 1.99e-02 0.336000 7.37e-02
Laminin interactions 25 3.63e-03 0.336000 1.90e-02
Regulation of RUNX3 expression and activity 45 1.01e-04 0.335000 1.00e-03
MET promotes cell motility 32 1.06e-03 0.334000 6.95e-03
Transferrin endocytosis and recycling 26 3.22e-03 0.334000 1.72e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 6.79e-02 0.333000 1.75e-01
SHC-related events triggered by IGF1R 7 1.27e-01 0.333000 2.69e-01
Dectin-2 family 18 1.46e-02 0.332000 5.78e-02
tRNA modification in the mitochondrion 9 8.49e-02 -0.332000 2.04e-01
Signaling by NOTCH4 68 2.25e-06 0.332000 5.68e-05
Free fatty acids regulate insulin secretion 10 6.97e-02 0.331000 1.79e-01
Degradation of beta-catenin by the destruction complex 72 1.17e-06 0.331000 3.63e-05
EPHB-mediated forward signaling 38 4.15e-04 0.331000 3.15e-03
Heme signaling 45 1.24e-04 0.331000 1.17e-03
HDMs demethylate histones 22 7.33e-03 0.330000 3.38e-02
ABC transporter disorders 59 1.15e-05 0.330000 1.96e-04
Signaling by CSF3 (G-CSF) 29 2.09e-03 0.330000 1.23e-02
ROS and RNS production in phagocytes 30 1.78e-03 0.330000 1.09e-02
FGFR2c ligand binding and activation 5 2.02e-01 0.330000 3.68e-01
PCNA-Dependent Long Patch Base Excision Repair 21 9.08e-03 -0.329000 4.00e-02
Digestion and absorption 7 1.32e-01 0.329000 2.74e-01
Activation of the AP-1 family of transcription factors 10 7.18e-02 0.329000 1.82e-01
Selenocysteine synthesis 92 5.12e-08 -0.328000 2.73e-06
Nephrin family interactions 19 1.33e-02 0.328000 5.34e-02
Expression and translocation of olfactory receptors 49 7.45e-05 0.327000 8.18e-04
NFE2L2 regulating MDR associated enzymes 8 1.09e-01 0.327000 2.44e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 5.04e-02 0.326000 1.43e-01
alpha-linolenic acid (ALA) metabolism 12 5.04e-02 0.326000 1.43e-01
Eukaryotic Translation Termination 92 6.64e-08 -0.326000 3.45e-06
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.29e-02 0.324000 1.67e-01
Regulation of NFE2L2 gene expression 8 1.13e-01 0.324000 2.50e-01
Interleukin-27 signaling 11 6.33e-02 0.323000 1.68e-01
Replacement of protamines by nucleosomes in the male pronucleus 12 5.25e-02 0.323000 1.47e-01
Viral mRNA Translation 88 1.88e-07 -0.321000 8.82e-06
Deadenylation of mRNA 22 9.16e-03 0.321000 4.03e-02
Signaling by MET 67 5.59e-06 0.321000 1.16e-04
Kidney development 16 2.64e-02 0.321000 8.96e-02
Interleukin-12 signaling 44 2.40e-04 0.320000 2.04e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 4.52e-06 0.319000 9.98e-05
Caspase activation via Dependence Receptors in the absence of ligand 9 9.77e-02 0.319000 2.26e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 4.67e-02 -0.319000 1.35e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 3.28e-02 0.318000 1.04e-01
Apoptotic cleavage of cell adhesion proteins 8 1.19e-01 0.318000 2.60e-01
Neutrophil degranulation 456 2.08e-31 0.318000 4.00e-28
Olfactory Signaling Pathway 54 5.28e-05 0.318000 6.15e-04
Beta-catenin phosphorylation cascade 17 2.33e-02 0.318000 8.24e-02
Signaling by EGFR in Cancer 22 9.89e-03 0.318000 4.24e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 1.46e-01 0.317000 2.95e-01
Activation of caspases through apoptosome-mediated cleavage 6 1.79e-01 0.317000 3.38e-01
Miro GTPase Cycle 8 1.21e-01 0.317000 2.61e-01
Regulation of PTEN stability and activity 55 5.06e-05 0.316000 5.97e-04
Initiation of Nuclear Envelope (NE) Reformation 19 1.72e-02 0.316000 6.60e-02
Antigen processing-Cross presentation 88 3.18e-07 0.315000 1.33e-05
Malate-aspartate shuttle 8 1.23e-01 -0.315000 2.64e-01
Alternative complement activation 5 2.23e-01 -0.315000 3.95e-01
RAF activation 32 2.15e-03 0.313000 1.26e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 4.29e-02 0.313000 1.28e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 1.55e-02 0.312000 6.05e-02
Mitochondrial RNA degradation 25 6.85e-03 0.312000 3.19e-02
Signaling by ERBB2 ECD mutants 15 3.64e-02 0.312000 1.12e-01
tRNA processing in the mitochondrion 24 8.15e-03 0.312000 3.67e-02
Stabilization of p53 43 4.01e-04 0.312000 3.08e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.86e-01 0.312000 3.46e-01
Formation of xylulose-5-phosphate 5 2.29e-01 -0.310000 3.99e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.25e-07 -0.309000 9.82e-06
Response to elevated platelet cytosolic Ca2+ 108 2.96e-08 0.309000 1.62e-06
DNA strand elongation 32 2.51e-03 -0.309000 1.42e-02
Detoxification of Reactive Oxygen Species 30 3.44e-03 0.309000 1.82e-02
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 4.03e-03 0.309000 2.06e-02
Induction of Cell-Cell Fusion 8 1.31e-01 0.308000 2.74e-01
RAC2 GTPase cycle 85 8.98e-07 0.308000 2.92e-05
Synthesis of PIPs at the plasma membrane 52 1.22e-04 0.308000 1.16e-03
PI-3K cascade:FGFR1 13 5.49e-02 0.307000 1.52e-01
Signal amplification 28 4.86e-03 0.307000 2.37e-02
p75NTR negatively regulates cell cycle via SC1 5 2.34e-01 0.307000 4.05e-01
Regulation of FOXO transcriptional activity by acetylation 10 9.32e-02 0.307000 2.18e-01
Cellular response to chemical stress 178 1.78e-12 0.306000 3.12e-10
DCC mediated attractive signaling 13 5.61e-02 0.306000 1.53e-01
Acetylcholine binding and downstream events 5 2.38e-01 0.305000 4.10e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.38e-01 0.305000 4.10e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 1.62e-01 0.305000 3.18e-01
Interleukin-12 family signaling 53 1.24e-04 0.305000 1.17e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 3.42e-05 0.304000 4.44e-04
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.64e-03 0.303000 1.01e-02
Regulation of RAS by GAPs 55 1.02e-04 0.303000 1.00e-03
Hydrolysis of LPC 8 1.38e-01 0.303000 2.84e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 2.65e-02 -0.302000 8.97e-02
Phosphorylation of CD3 and TCR zeta chains 27 6.60e-03 -0.302000 3.09e-02
IRAK2 mediated activation of TAK1 complex 10 9.82e-02 0.302000 2.27e-01
Regulation of TLR by endogenous ligand 15 4.30e-02 0.302000 1.28e-01
Regulation of KIT signaling 15 4.31e-02 0.302000 1.28e-01
Metabolism of polyamines 46 4.05e-04 0.301000 3.10e-03
InlB-mediated entry of Listeria monocytogenes into host cell 12 7.12e-02 0.301000 1.81e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.33e-02 0.301000 8.24e-02
Formation of paraxial mesoderm 52 1.77e-04 0.301000 1.56e-03
Signaling by RNF43 mutants 7 1.69e-01 0.300000 3.24e-01
VEGFA-VEGFR2 Pathway 93 5.89e-07 0.300000 2.22e-05
RUNX2 regulates genes involved in cell migration 6 2.04e-01 -0.300000 3.70e-01
Uptake of dietary cobalamins into enterocytes 5 2.47e-01 -0.299000 4.21e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 9.62e-03 0.299000 4.16e-02
Classical antibody-mediated complement activation 69 1.77e-05 -0.299000 2.70e-04
NrCAM interactions 6 2.05e-01 -0.299000 3.71e-01
Platelet degranulation 104 1.45e-07 0.298000 7.15e-06
Nef Mediated CD8 Down-regulation 7 1.72e-01 0.298000 3.28e-01
Serine biosynthesis 8 1.45e-01 0.298000 2.93e-01
Cytoprotection by HMOX1 53 1.78e-04 0.298000 1.56e-03
UCH proteinases 73 1.13e-05 0.297000 1.93e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 6.01e-05 0.297000 6.89e-04
p130Cas linkage to MAPK signaling for integrins 11 8.81e-02 0.297000 2.10e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 4.58e-05 0.297000 5.50e-04
DAP12 signaling 28 6.59e-03 0.297000 3.09e-02
IRAK1 recruits IKK complex 14 5.51e-02 0.296000 1.52e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 5.51e-02 0.296000 1.52e-01
PI3K events in ERBB2 signaling 11 8.93e-02 0.296000 2.12e-01
Creation of C4 and C2 activators 71 1.64e-05 -0.296000 2.62e-04
SUMO is conjugated to E1 (UBA2:SAE1) 5 2.52e-01 0.296000 4.28e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 1.06e-01 0.295000 2.40e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 7.76e-05 0.295000 8.33e-04
Golgi Associated Vesicle Biogenesis 55 1.54e-04 0.295000 1.41e-03
CLEC7A (Dectin-1) signaling 85 2.66e-06 0.295000 6.63e-05
Na+/Cl- dependent neurotransmitter transporters 7 1.77e-01 0.295000 3.35e-01
RHOG GTPase cycle 70 2.03e-05 0.295000 3.05e-04
Scavenging of heme from plasma 70 2.07e-05 -0.294000 3.08e-04
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 6.65e-02 0.294000 1.73e-01
G2 Phase 5 2.55e-01 0.294000 4.31e-01
Asymmetric localization of PCP proteins 49 3.76e-04 0.294000 2.91e-03
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 7.82e-02 0.294000 1.92e-01
Transport of connexons to the plasma membrane 12 7.82e-02 0.294000 1.92e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 4.90e-02 0.294000 1.40e-01
LGI-ADAM interactions 9 1.28e-01 -0.293000 2.70e-01
Toxicity of botulinum toxin type D (botD) 5 2.57e-01 -0.293000 4.32e-01
Toxicity of botulinum toxin type F (botF) 5 2.57e-01 -0.293000 4.32e-01
Signaling by SCF-KIT 40 1.38e-03 0.292000 8.73e-03
Diseases of Mismatch Repair (MMR) 5 2.59e-01 0.292000 4.33e-01
WNT5A-dependent internalization of FZD4 13 6.88e-02 0.292000 1.77e-01
Signaling by FGFR3 32 4.35e-03 0.291000 2.18e-02
Formation of a pool of free 40S subunits 100 4.83e-07 -0.291000 1.89e-05
Golgi Cisternae Pericentriolar Stack Reorganization 14 5.92e-02 0.291000 1.60e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 5.81e-03 0.291000 2.77e-02
Sema4D mediated inhibition of cell attachment and migration 7 1.83e-01 0.291000 3.43e-01
RHOF GTPase cycle 38 1.93e-03 0.291000 1.17e-02
Generation of second messenger molecules 38 1.95e-03 -0.290000 1.18e-02
Interleukin-10 signaling 36 2.58e-03 0.290000 1.45e-02
RORA activates gene expression 18 3.32e-02 0.290000 1.05e-01
APC/C:Cdc20 mediated degradation of Securin 55 2.13e-04 0.289000 1.83e-03
RAC3 GTPase cycle 86 3.77e-06 0.288000 8.63e-05
PCP/CE pathway 74 1.80e-05 0.288000 2.72e-04
Interleukin-1 family signaling 127 2.14e-08 0.288000 1.29e-06
Synthesis of Ketone Bodies 6 2.23e-01 -0.287000 3.95e-01
Alpha-oxidation of phytanate 6 2.24e-01 -0.287000 3.95e-01
Negative feedback regulation of MAPK pathway 6 2.24e-01 0.287000 3.95e-01
Recycling of bile acids and salts 8 1.61e-01 0.286000 3.18e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.50e-02 0.285000 1.88e-01
MAP kinase activation 63 9.10e-05 0.285000 9.30e-04
ADP signalling through P2Y purinoceptor 12 18 3.65e-02 0.285000 1.12e-01
Signaling by LTK 10 1.19e-01 0.284000 2.60e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 1.03e-01 -0.284000 2.35e-01
Growth hormone receptor signaling 20 2.84e-02 0.283000 9.41e-02
Late endosomal microautophagy 30 7.35e-03 0.283000 3.38e-02
Josephin domain DUBs 10 1.22e-01 0.283000 2.62e-01
Pyrimidine catabolism 9 1.42e-01 0.283000 2.89e-01
Incretin synthesis, secretion, and inactivation 14 6.71e-02 0.283000 1.73e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 6.71e-02 0.283000 1.73e-01
TNFs bind their physiological receptors 25 1.45e-02 -0.283000 5.72e-02
Spry regulation of FGF signaling 16 5.05e-02 0.282000 1.43e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 2.74e-01 -0.282000 4.48e-01
rRNA processing in the nucleus and cytosol 189 2.22e-11 -0.282000 2.85e-09
Maternal to zygotic transition (MZT) 71 3.97e-05 0.282000 4.99e-04
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 1.43e-01 0.282000 2.91e-01
Regulation of innate immune responses to cytosolic DNA 14 6.82e-02 -0.282000 1.76e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 9.81e-05 0.282000 9.82e-04
O-linked glycosylation of mucins 46 9.60e-04 0.281000 6.38e-03
PTK6 Regulates Cell Cycle 6 2.33e-01 -0.281000 4.04e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 9.41e-11 -0.281000 1.06e-08
Initial triggering of complement 79 1.69e-05 -0.280000 2.67e-04
FGFR3 ligand binding and activation 5 2.79e-01 0.280000 4.53e-01
FGFR3c ligand binding and activation 5 2.79e-01 0.280000 4.53e-01
Negative regulation of FGFR3 signaling 21 2.65e-02 0.280000 8.97e-02
Sulfur amino acid metabolism 22 2.32e-02 -0.280000 8.24e-02
CDK-mediated phosphorylation and removal of Cdc6 60 1.81e-04 0.279000 1.58e-03
Signalling to ERKs 32 6.33e-03 0.279000 3.01e-02
Sensing of DNA Double Strand Breaks 6 2.38e-01 0.278000 4.10e-01
Proteasome assembly 50 6.64e-04 0.278000 4.64e-03
Autodegradation of Cdh1 by Cdh1:APC/C 54 4.14e-04 0.278000 3.15e-03
Common Pathway of Fibrin Clot Formation 13 8.30e-02 0.278000 2.01e-01
VxPx cargo-targeting to cilium 19 3.63e-02 0.277000 1.12e-01
Sodium/Calcium exchangers 9 1.50e-01 0.277000 2.99e-01
Post-translational protein phosphorylation 67 8.78e-05 0.277000 9.12e-04
Estrogen biosynthesis 5 2.84e-01 0.277000 4.56e-01
SHC-mediated cascade:FGFR3 10 1.30e-01 0.277000 2.71e-01
Signaling by ERBB2 in Cancer 21 2.81e-02 0.277000 9.37e-02
G-protein activation 19 3.69e-02 0.277000 1.12e-01
Constitutive Signaling by Overexpressed ERBB2 11 1.13e-01 0.276000 2.50e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 2.43e-01 -0.276000 4.17e-01
RHOBTB2 GTPase cycle 23 2.23e-02 0.275000 8.07e-02
ER-Phagosome pathway 74 4.28e-05 0.275000 5.30e-04
Downregulation of ERBB2:ERBB3 signaling 12 9.90e-02 -0.275000 2.27e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 6.80e-04 0.275000 4.73e-03
Gastrulation 73 5.00e-05 0.274000 5.93e-04
p53-Dependent G1 DNA Damage Response 52 6.22e-04 0.274000 4.41e-03
p53-Dependent G1/S DNA damage checkpoint 52 6.22e-04 0.274000 4.41e-03
Transcriptional regulation by RUNX3 80 2.23e-05 0.274000 3.27e-04
Downstream signaling of activated FGFR4 18 4.44e-02 0.274000 1.31e-01
FLT3 Signaling 38 3.54e-03 0.273000 1.87e-02
EPH-Ephrin signaling 79 2.69e-05 0.273000 3.80e-04
Lagging Strand Synthesis 20 3.45e-02 -0.273000 1.07e-01
TGF-beta receptor signaling activates SMADs 45 1.60e-03 0.272000 9.95e-03
Inactivation of CSF3 (G-CSF) signaling 24 2.17e-02 0.271000 7.89e-02
Molybdenum cofactor biosynthesis 6 2.51e-01 -0.270000 4.26e-01
MAP2K and MAPK activation 36 5.01e-03 0.270000 2.43e-02
Chromatin modifications during the maternal to zygotic transition (MZT) 23 2.50e-02 0.270000 8.62e-02
Folding of actin by CCT/TriC 10 1.40e-01 0.269000 2.88e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 1.75e-05 0.269000 2.70e-04
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 1.75e-05 0.269000 2.70e-04
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 1.75e-05 0.269000 2.70e-04
Uptake and actions of bacterial toxins 27 1.56e-02 0.269000 6.05e-02
ADP signalling through P2Y purinoceptor 1 21 3.30e-02 0.269000 1.04e-01
Transcriptional Regulation by NPAS4 27 1.58e-02 0.268000 6.12e-02
RNA Polymerase I Promoter Opening 17 5.59e-02 0.268000 1.53e-01
Signaling by Insulin receptor 63 2.46e-04 0.267000 2.08e-03
Linoleic acid (LA) metabolism 7 2.22e-01 0.267000 3.94e-01
Regulation of PTEN localization 9 1.66e-01 0.267000 3.22e-01
C-type lectin receptors (CLRs) 116 7.10e-07 0.266000 2.44e-05
L1CAM interactions 100 4.34e-06 0.266000 9.82e-05
Signaling by WNT in cancer 30 1.18e-02 0.266000 4.94e-02
Platelet activation, signaling and aggregation 219 1.43e-11 0.265000 1.97e-09
Aggrephagy 34 7.55e-03 0.265000 3.44e-02
MET activates RAS signaling 10 1.47e-01 0.265000 2.96e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.59e-02 0.264000 1.11e-01
Downstream signaling of activated FGFR1 22 3.18e-02 0.264000 1.02e-01
Calnexin/calreticulin cycle 26 1.98e-02 0.264000 7.33e-02
FasL/ CD95L signaling 5 3.07e-01 -0.264000 4.84e-01
Interleukin-17 signaling 68 1.72e-04 0.263000 1.53e-03
SARS-CoV-2 modulates host translation machinery 49 1.43e-03 -0.263000 9.02e-03
Platelet homeostasis 69 1.56e-04 0.263000 1.42e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 5.32e-02 0.263000 1.49e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 5.32e-02 0.263000 1.49e-01
Glycogen breakdown (glycogenolysis) 12 1.15e-01 0.263000 2.52e-01
RAS signaling downstream of NF1 loss-of-function variants 7 2.29e-01 0.263000 3.99e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.31e-02 0.262000 1.05e-01
SHC1 events in ERBB2 signaling 17 6.11e-02 0.262000 1.64e-01
Signaling by VEGF 100 5.81e-06 0.262000 1.16e-04
IKK complex recruitment mediated by RIP1 23 2.95e-02 0.262000 9.66e-02
SHC1 events in ERBB4 signaling 10 1.51e-01 0.262000 3.02e-01
Regulation of APC/C activators between G1/S and early anaphase 68 1.95e-04 0.261000 1.68e-03
Regulation of RUNX2 expression and activity 54 9.13e-04 0.261000 6.11e-03
Downstream signaling of activated FGFR2 20 4.35e-02 0.261000 1.29e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 74 1.07e-04 0.260000 1.04e-03
Early SARS-CoV-2 Infection Events 30 1.37e-02 0.260000 5.43e-02
Noncanonical activation of NOTCH3 8 2.03e-01 0.260000 3.70e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 1.37e-02 0.260000 5.43e-02
Regulation of CDH19 Expression and Function 5 3.14e-01 0.260000 4.90e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 1.37e-01 0.259000 2.83e-01
G1/S DNA Damage Checkpoints 54 1.01e-03 0.259000 6.68e-03
Toll Like Receptor 2 (TLR2) Cascade 109 3.31e-06 0.258000 7.84e-05
Toll Like Receptor TLR1:TLR2 Cascade 109 3.31e-06 0.258000 7.84e-05
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 9.43e-04 0.258000 6.29e-03
FRS-mediated FGFR4 signaling 13 1.08e-01 0.258000 2.42e-01
Processive synthesis on the lagging strand 15 8.40e-02 -0.258000 2.02e-01
Sodium/Proton exchangers 7 2.38e-01 0.258000 4.10e-01
G beta:gamma signalling through BTK 15 8.43e-02 0.257000 2.02e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 8.68e-06 -0.257000 1.53e-04
Ketone body metabolism 8 2.08e-01 -0.257000 3.75e-01
Heme degradation 10 1.61e-01 0.256000 3.17e-01
Syndecan interactions 23 3.37e-02 0.256000 1.06e-01
Golgi-to-ER retrograde transport 123 9.56e-07 0.256000 3.06e-05
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 10 1.62e-01 0.256000 3.18e-01
Formation of the beta-catenin:TCF transactivating complex 44 3.40e-03 0.255000 1.80e-02
Hedgehog ‘on’ state 65 3.75e-04 0.255000 2.91e-03
Clathrin-mediated endocytosis 127 6.94e-07 0.255000 2.42e-05
FCGR activation 76 1.24e-04 -0.255000 1.17e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 4.90e-06 0.254000 1.06e-04
Toll Like Receptor TLR6:TLR2 Cascade 108 4.90e-06 0.254000 1.06e-04
RHOJ GTPase cycle 49 2.06e-03 0.254000 1.22e-02
FGFR2b ligand binding and activation 6 2.81e-01 -0.254000 4.54e-01
Signaling by ERBB2 KD Mutants 20 4.92e-02 0.254000 1.40e-01
GABA synthesis, release, reuptake and degradation 12 1.28e-01 -0.254000 2.69e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 8.14e-02 -0.252000 1.99e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 2.18e-02 0.250000 7.91e-02
NFE2L2 regulating tumorigenic genes 11 1.50e-01 0.250000 3.00e-01
Triglyceride catabolism 15 9.35e-02 0.250000 2.18e-01
Tie2 Signaling 16 8.34e-02 0.250000 2.01e-01
Signaling by high-kinase activity BRAF mutants 33 1.30e-02 0.250000 5.27e-02
Signaling by ERBB4 45 3.74e-03 0.250000 1.94e-02
Thyroxine biosynthesis 5 3.33e-01 -0.250000 5.08e-01
Cellular responses to mechanical stimuli 83 8.43e-05 0.250000 8.89e-04
Response of endothelial cells to shear stress 83 8.43e-05 0.250000 8.89e-04
Reelin signalling pathway 5 3.36e-01 0.248000 5.09e-01
Recycling pathway of L1 40 6.59e-03 0.248000 3.09e-02
Circadian Clock 67 4.47e-04 0.248000 3.32e-03
Tight junction interactions 17 7.69e-02 -0.248000 1.91e-01
Thromboxane signalling through TP receptor 20 5.56e-02 0.247000 1.53e-01
ABC-family proteins mediated transport 81 1.20e-04 0.247000 1.15e-03
CLEC7A/inflammasome pathway 6 2.94e-01 0.247000 4.68e-01
Estrogen-dependent gene expression 96 2.86e-05 0.247000 3.95e-04
Formation of annular gap junctions 10 1.77e-01 0.247000 3.35e-01
Platelet calcium homeostasis 22 4.52e-02 0.247000 1.32e-01
Protein ubiquitination 71 3.29e-04 0.246000 2.62e-03
Myogenesis 20 5.68e-02 0.246000 1.55e-01
Gap junction assembly 16 8.85e-02 0.246000 2.11e-01
Gap junction trafficking 27 2.72e-02 0.246000 9.15e-02
Netrin-1 signaling 34 1.33e-02 0.245000 5.34e-02
CREB3 factors activate genes 6 2.98e-01 -0.245000 4.73e-01
PI5P Regulates TP53 Acetylation 8 2.30e-01 0.245000 3.99e-01
RHOD GTPase cycle 49 2.99e-03 0.245000 1.63e-02
Gap junction degradation 11 1.60e-01 0.245000 3.16e-01
MyD88 cascade initiated on plasma membrane 95 3.82e-05 0.244000 4.82e-04
Toll Like Receptor 10 (TLR10) Cascade 95 3.82e-05 0.244000 4.82e-04
Toll Like Receptor 5 (TLR5) Cascade 95 3.82e-05 0.244000 4.82e-04
RHOC GTPase cycle 71 3.75e-04 0.244000 2.91e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 6.83e-06 -0.244000 1.27e-04
Nonsense-Mediated Decay (NMD) 114 6.83e-06 -0.244000 1.27e-04
Sema4D in semaphorin signaling 22 4.80e-02 0.244000 1.38e-01
Respiratory syncytial virus (RSV) attachment and entry 17 8.23e-02 0.243000 2.00e-01
Ub-specific processing proteases 153 2.06e-07 0.243000 9.21e-06
trans-Golgi Network Vesicle Budding 69 4.88e-04 0.243000 3.58e-03
Inwardly rectifying K+ channels 22 4.88e-02 0.243000 1.39e-01
ERBB2 Regulates Cell Motility 10 1.84e-01 0.243000 3.45e-01
FRS-mediated FGFR2 signaling 15 1.04e-01 0.243000 2.35e-01
Beta-catenin independent WNT signaling 124 3.16e-06 0.242000 7.68e-05
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.17e-02 0.242000 7.89e-02
LDL clearance 18 7.53e-02 0.242000 1.89e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 2.79e-03 0.242000 1.55e-02
cGMP effects 12 1.47e-01 0.242000 2.95e-01
Interleukin-35 Signalling 12 1.47e-01 0.242000 2.96e-01
Signaling by FGFR4 32 1.80e-02 0.242000 6.78e-02
Iron uptake and transport 52 2.59e-03 0.241000 1.45e-02
Diseases of branched-chain amino acid catabolism 13 1.32e-01 -0.241000 2.74e-01
Lipophagy 7 2.69e-01 0.241000 4.44e-01
APC/C-mediated degradation of cell cycle proteins 75 3.00e-04 0.241000 2.48e-03
Regulation of mitotic cell cycle 75 3.00e-04 0.241000 2.48e-03
Sealing of the nuclear envelope (NE) by ESCRT-III 24 4.11e-02 0.241000 1.23e-01
Interleukin-15 signaling 14 1.19e-01 0.240000 2.60e-01
G beta:gamma signalling through CDC42 17 8.64e-02 0.240000 2.07e-01
Long-term potentiation 14 1.20e-01 -0.240000 2.60e-01
PKA activation 15 1.07e-01 0.240000 2.42e-01
Interleukin-4 and Interleukin-13 signaling 89 9.17e-05 0.240000 9.32e-04
Activation of gene expression by SREBF (SREBP) 42 7.19e-03 0.240000 3.32e-02
Deubiquitination 225 5.86e-10 0.240000 4.89e-08
Activation of RAC1 downstream of NMDARs 7 2.72e-01 0.240000 4.47e-01
ER to Golgi Anterograde Transport 145 6.36e-07 0.240000 2.31e-05
Signaling by NTRK2 (TRKB) 20 6.43e-02 0.239000 1.70e-01
Semaphorin interactions 56 2.00e-03 0.239000 1.20e-02
Defective RIPK1-mediated regulated necrosis 7 2.74e-01 -0.239000 4.48e-01
VLDLR internalisation and degradation 16 9.87e-02 0.238000 2.27e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 3.91e-02 0.238000 1.18e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 3.56e-01 -0.238000 5.29e-01
O-glycosylation of TSR domain-containing proteins 25 3.99e-02 -0.237000 1.20e-01
GP1b-IX-V activation signalling 10 1.94e-01 0.237000 3.57e-01
Selenoamino acid metabolism 115 1.17e-05 -0.237000 1.96e-04
Regulation of mRNA stability by proteins that bind AU-rich elements 76 3.83e-04 0.236000 2.96e-03
rRNA processing 213 3.19e-09 -0.235000 2.45e-07
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 9.30e-02 -0.235000 2.18e-01
COPI-mediated anterograde transport 92 1.01e-04 0.235000 1.00e-03
Gap junction trafficking and regulation 29 2.89e-02 0.234000 9.50e-02
Rap1 signalling 14 1.29e-01 0.234000 2.71e-01
RAB GEFs exchange GTP for GDP on RABs 89 1.44e-04 0.233000 1.33e-03
RHO GTPase Effectors 257 1.24e-10 0.233000 1.27e-08
PI Metabolism 79 3.44e-04 0.233000 2.73e-03
Other semaphorin interactions 16 1.07e-01 0.233000 2.42e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 2.48e-05 -0.233000 3.59e-04
RUNX3 regulates p14-ARF 10 2.03e-01 0.232000 3.70e-01
TP53 Regulates Metabolic Genes 77 4.33e-04 0.232000 3.22e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 2.28e-01 0.232000 3.99e-01
Orc1 removal from chromatin 58 2.27e-03 0.232000 1.32e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 6.63e-02 0.231000 1.73e-01
Neurodegenerative Diseases 21 6.63e-02 0.231000 1.73e-01
Activation of RAC1 11 1.85e-01 0.231000 3.46e-01
RA biosynthesis pathway 13 1.49e-01 -0.231000 2.98e-01
MECP2 regulates transcription of neuronal ligands 5 3.71e-01 -0.231000 5.48e-01
Creatine metabolism 7 2.91e-01 -0.231000 4.64e-01
Activation of the pre-replicative complex 32 2.40e-02 -0.231000 8.44e-02
COPII-mediated vesicle transport 67 1.10e-03 0.230000 7.19e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 8.21e-03 0.230000 3.68e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 3.19e-02 0.230000 1.02e-01
Sema4D induced cell migration and growth-cone collapse 19 8.27e-02 0.230000 2.01e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 2.09e-01 0.229000 3.77e-01
Membrane Trafficking 575 5.07e-21 0.229000 2.44e-18
Signaling by TGF-beta Receptor Complex 90 1.71e-04 0.229000 1.53e-03
Synthesis of GDP-mannose 6 3.31e-01 -0.229000 5.06e-01
Sema3A PAK dependent Axon repulsion 15 1.25e-01 0.229000 2.66e-01
MyD88 dependent cascade initiated on endosome 101 6.95e-05 0.229000 7.72e-04
Signaling by RAF1 mutants 36 1.74e-02 0.229000 6.64e-02
Negative regulation of FLT3 15 1.25e-01 0.229000 2.66e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 7.83e-05 0.229000 8.36e-04
Cyclin E associated events during G1/S transition 73 7.68e-04 0.228000 5.27e-03
Signaling by Interleukins 387 1.46e-14 0.228000 3.12e-12
Amino acids regulate mTORC1 48 6.37e-03 0.228000 3.02e-02
Negative regulation of FGFR4 signaling 22 6.48e-02 0.227000 1.71e-01
Peptide hormone metabolism 53 4.20e-03 0.227000 2.12e-02
Advanced glycosylation endproduct receptor signaling 12 1.73e-01 0.227000 3.30e-01
Interleukin-7 signaling 21 7.14e-02 0.227000 1.81e-01
Regulation of IFNA/IFNB signaling 12 1.73e-01 0.227000 3.30e-01
RAC1 GTPase cycle 170 3.36e-07 0.227000 1.37e-05
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 3.37e-01 0.226000 5.09e-01
GRB2 events in ERBB2 signaling 11 1.94e-01 0.226000 3.57e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 3.82e-01 -0.226000 5.59e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 6.48e-05 0.226000 7.28e-04
tRNA modification in the nucleus and cytosol 43 1.06e-02 -0.225000 4.49e-02
RHOT2 GTPase cycle 7 3.03e-01 0.225000 4.78e-01
Mitochondrial Uncoupling 6 3.42e-01 -0.224000 5.15e-01
Toll Like Receptor 9 (TLR9) Cascade 108 5.72e-05 0.224000 6.62e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 2.48e-03 0.224000 1.41e-02
Interleukin-6 family signaling 18 1.00e-01 0.224000 2.29e-01
Budding and maturation of HIV virion 26 4.83e-02 0.224000 1.38e-01
Toll Like Receptor 4 (TLR4) Cascade 138 5.72e-06 0.224000 1.16e-04
TCF dependent signaling in response to WNT 151 2.19e-06 0.223000 5.64e-05
Leading Strand Synthesis 14 1.48e-01 -0.223000 2.97e-01
Polymerase switching 14 1.48e-01 -0.223000 2.97e-01
Transcriptional regulation by RUNX1 170 5.37e-07 0.223000 2.06e-05
Influenza Viral RNA Transcription and Replication 135 8.35e-06 -0.222000 1.50e-04
Role of phospholipids in phagocytosis 88 3.28e-04 -0.222000 2.62e-03
Cap-dependent Translation Initiation 118 3.27e-05 -0.221000 4.33e-04
Eukaryotic Translation Initiation 118 3.27e-05 -0.221000 4.33e-04
Transport to the Golgi and subsequent modification 170 6.63e-07 0.221000 2.36e-05
Regulation of signaling by CBL 22 7.33e-02 0.221000 1.84e-01
Negative regulation of FGFR2 signaling 24 6.15e-02 0.220000 1.65e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.40e-02 0.220000 8.44e-02
CREB phosphorylation 7 3.13e-01 0.220000 4.89e-01
Factors involved in megakaryocyte development and platelet production 128 1.67e-05 0.220000 2.64e-04
GTP hydrolysis and joining of the 60S ribosomal subunit 111 6.06e-05 -0.220000 6.89e-04
mTORC1-mediated signalling 24 6.17e-02 0.220000 1.65e-01
Defensins 8 2.81e-01 -0.220000 4.54e-01
Removal of the Flap Intermediate 14 1.55e-01 -0.220000 3.07e-01
Activation of AMPK downstream of NMDARs 20 8.94e-02 0.219000 2.12e-01
Acyl chain remodelling of PI 10 2.31e-01 0.219000 4.01e-01
Zygotic genome activation (ZGA) 5 3.98e-01 0.218000 5.76e-01
Apoptotic execution phase 46 1.05e-02 0.218000 4.46e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 1.27e-02 0.217000 5.15e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 3.57e-01 -0.217000 5.30e-01
Telomere C-strand (Lagging Strand) Synthesis 34 2.84e-02 -0.217000 9.41e-02
Aryl hydrocarbon receptor signalling 6 3.57e-01 0.217000 5.30e-01
Transcriptional regulation of pluripotent stem cells 18 1.11e-01 0.217000 2.47e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.93e-01 -0.217000 3.56e-01
Maturation of nucleoprotein 9694631 15 1.47e-01 0.216000 2.95e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.35e-01 0.216000 2.78e-01
NOTCH2 intracellular domain regulates transcription 11 2.15e-01 0.216000 3.86e-01
Mitochondrial protein import 63 3.05e-03 -0.216000 1.65e-02
Toll-like Receptor Cascades 162 2.14e-06 0.216000 5.64e-05
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 4.48e-02 0.215000 1.31e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 4.05e-01 -0.215000 5.83e-01
Maple Syrup Urine Disease 5 4.05e-01 -0.215000 5.83e-01
Signaling by WNT 237 1.21e-08 0.215000 7.50e-07
Listeria monocytogenes entry into host cells 17 1.26e-01 0.214000 2.68e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 60 4.10e-03 0.214000 2.08e-02
RHOQ GTPase cycle 54 6.49e-03 0.214000 3.06e-02
Neurofascin interactions 5 4.07e-01 0.214000 5.85e-01
Receptor Mediated Mitophagy 11 2.19e-01 0.214000 3.91e-01
Attachment of GPI anchor to uPAR 7 3.27e-01 0.214000 5.02e-01
Cholesterol biosynthesis 26 5.92e-02 0.214000 1.60e-01
Collagen degradation 41 1.79e-02 0.214000 6.77e-02
SUMOylation of intracellular receptors 26 5.97e-02 0.213000 1.61e-01
Base Excision Repair 56 5.76e-03 -0.213000 2.76e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 3.69e-02 0.213000 1.12e-01
Peptide ligand-binding receptors 100 2.33e-04 0.213000 1.99e-03
Bacterial Infection Pathways 65 3.03e-03 0.213000 1.65e-02
Separation of Sister Chromatids 167 2.18e-06 0.212000 5.64e-05
MASTL Facilitates Mitotic Progression 10 2.45e-01 0.212000 4.19e-01
rRNA modification in the nucleus and cytosol 59 4.80e-03 -0.212000 2.35e-02
ESR-mediated signaling 157 4.45e-06 0.212000 9.95e-05
ADORA2B mediated anti-inflammatory cytokines production 35 2.99e-02 0.212000 9.73e-02
MECP2 regulates neuronal receptors and channels 13 1.86e-01 0.212000 3.46e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 6.69e-02 -0.212000 1.73e-01
Packaging Of Telomere Ends 18 1.21e-01 0.211000 2.61e-01
Arachidonate production from DAG 5 4.14e-01 -0.211000 5.89e-01
Polymerase switching on the C-strand of the telomere 26 6.24e-02 -0.211000 1.67e-01
Branched-chain amino acid catabolism 21 9.50e-02 -0.210000 2.21e-01
RUNX3 regulates NOTCH signaling 14 1.73e-01 0.210000 3.30e-01
Regulation of gene expression in beta cells 7 3.35e-01 -0.210000 5.09e-01
Glycine degradation 7 3.36e-01 0.210000 5.09e-01
Defective B3GALTL causes PpS 24 7.52e-02 -0.210000 1.88e-01
Mitochondrial translation initiation 90 5.88e-04 -0.210000 4.23e-03
Prolactin receptor signaling 11 2.29e-01 0.209000 3.99e-01
Negative regulation of FGFR1 signaling 25 7.01e-02 0.209000 1.79e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 7.01e-02 0.209000 1.79e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 7.01e-02 0.209000 1.79e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 7.01e-02 0.209000 1.79e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 7.01e-02 0.209000 1.79e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 6.03e-04 0.209000 4.32e-03
Intra-Golgi and retrograde Golgi-to-ER traffic 191 6.20e-07 0.209000 2.29e-05
Signaling by NOTCH 173 2.09e-06 0.209000 5.64e-05
Cytochrome P450 - arranged by substrate type 33 3.78e-02 0.209000 1.15e-01
Intra-Golgi traffic 43 1.80e-02 0.209000 6.77e-02
Pre-NOTCH Transcription and Translation 47 1.34e-02 0.208000 5.38e-02
Neurotransmitter clearance 6 3.77e-01 0.208000 5.53e-01
Apoptotic cleavage of cellular proteins 35 3.32e-02 0.208000 1.05e-01
Mitotic Anaphase 210 2.03e-07 0.208000 9.21e-06
N-Glycan antennae elongation 12 2.13e-01 0.208000 3.83e-01
G alpha (z) signalling events 36 3.13e-02 0.207000 1.00e-01
Transcriptional regulation of granulopoiesis 44 1.74e-02 0.207000 6.64e-02
Opioid Signalling 74 2.07e-03 0.207000 1.22e-02
RHOH GTPase cycle 33 3.96e-02 0.207000 1.19e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 3.43e-01 0.207000 5.16e-01
Acyl chain remodeling of CL 5 4.23e-01 0.207000 5.99e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.67e-04 -0.207000 1.50e-03
Hedgehog ‘off’ state 91 6.56e-04 0.207000 4.60e-03
RHOB GTPase cycle 64 4.29e-03 0.206000 2.16e-02
Formation of definitive endoderm 8 3.13e-01 0.206000 4.90e-01
Downstream signal transduction 27 6.43e-02 0.206000 1.70e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.42e-01 -0.206000 2.89e-01
Mitotic Metaphase and Anaphase 211 2.92e-07 0.205000 1.25e-05
Glutathione synthesis and recycling 10 2.63e-01 0.204000 4.38e-01
Nonhomologous End-Joining (NHEJ) 40 2.54e-02 0.204000 8.73e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 1.24e-01 0.204000 2.65e-01
Trafficking of AMPA receptors 19 1.24e-01 0.204000 2.65e-01
Keratan sulfate biosynthesis 19 1.24e-01 0.204000 2.65e-01
GABA receptor activation 35 3.71e-02 0.204000 1.13e-01
Histidine catabolism 7 3.51e-01 -0.204000 5.25e-01
Role of LAT2/NTAL/LAB on calcium mobilization 77 2.03e-03 -0.203000 1.21e-02
SMAC (DIABLO) binds to IAPs 7 3.52e-01 0.203000 5.25e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 3.52e-01 0.203000 5.25e-01
SMAC, XIAP-regulated apoptotic response 7 3.52e-01 0.203000 5.25e-01
Vitamin C (ascorbate) metabolism 8 3.20e-01 0.203000 4.94e-01
DNA Damage/Telomere Stress Induced Senescence 42 2.28e-02 0.203000 8.15e-02
RHO GTPases Activate Rhotekin and Rhophilins 8 3.21e-01 -0.203000 4.95e-01
Nef Mediated CD4 Down-regulation 9 2.93e-01 0.203000 4.66e-01
Interleukin-37 signaling 19 1.27e-01 0.202000 2.69e-01
ER Quality Control Compartment (ERQC) 21 1.09e-01 0.202000 2.44e-01
Glycogen metabolism 21 1.09e-01 0.202000 2.44e-01
The NLRP3 inflammasome 16 1.62e-01 0.202000 3.18e-01
Late SARS-CoV-2 Infection Events 63 5.63e-03 0.202000 2.71e-02
Downregulation of ERBB4 signaling 8 3.24e-01 0.202000 4.97e-01
Defects in vitamin and cofactor metabolism 21 1.10e-01 -0.202000 2.45e-01
G2/M Checkpoints 126 9.47e-05 0.201000 9.52e-04
Diseases of signal transduction by growth factor receptors and second messengers 399 5.04e-12 0.201000 7.45e-10
Formation of the ternary complex, and subsequently, the 43S complex 51 1.29e-02 -0.201000 5.22e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 3.58e-01 0.201000 5.30e-01
MAPK family signaling cascades 259 2.68e-08 0.201000 1.51e-06
Signaling by Rho GTPases 603 3.93e-17 0.201000 1.20e-14
Regulation of pyruvate metabolism 32 4.96e-02 0.201000 1.41e-01
Signaling by Receptor Tyrosine Kinases 443 4.94e-13 0.200000 9.49e-11
SUMO is proteolytically processed 6 3.98e-01 0.199000 5.76e-01
Impaired BRCA2 binding to PALB2 24 9.12e-02 0.199000 2.15e-01
Mitochondrial translation elongation 90 1.09e-03 -0.199000 7.13e-03
Defective binding of VWF variant to GPIb:IX:V 5 4.41e-01 0.199000 6.16e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 4.41e-01 0.199000 6.16e-01
Cargo recognition for clathrin-mediated endocytosis 88 1.25e-03 0.199000 8.00e-03
Assembly of the ORC complex at the origin of replication 23 9.96e-02 0.198000 2.28e-01
MyD88-independent TLR4 cascade 108 3.73e-04 0.198000 2.91e-03
TRIF (TICAM1)-mediated TLR4 signaling 108 3.73e-04 0.198000 2.91e-03
Cyclin A:Cdk2-associated events at S phase entry 75 3.02e-03 0.198000 1.64e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 4.36e-17 0.198000 1.20e-14
Oncogenic MAPK signaling 75 3.09e-03 0.198000 1.67e-02
Signaling by PDGF 48 1.79e-02 0.197000 6.77e-02
Signaling by BRAF and RAF1 fusions 59 8.75e-03 0.197000 3.87e-02
Thrombin signalling through proteinase activated receptors (PARs) 27 7.61e-02 0.197000 1.90e-01
RHOA GTPase cycle 138 6.84e-05 0.196000 7.64e-04
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 1.75e-02 0.196000 6.64e-02
Ca2+ pathway 57 1.05e-02 0.196000 4.44e-02
Intrinsic Pathway of Fibrin Clot Formation 15 1.89e-01 0.196000 3.50e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 1.68e-02 0.195000 6.48e-02
FOXO-mediated transcription 57 1.07e-02 0.195000 4.52e-02
Aquaporin-mediated transport 38 3.74e-02 0.195000 1.13e-01
MITF-M-dependent gene expression 81 2.46e-03 0.195000 1.41e-02
Signaling by NOTCH3 42 2.91e-02 0.195000 9.57e-02
HSF1-dependent transactivation 28 7.54e-02 0.194000 1.89e-01
Condensation of Prometaphase Chromosomes 11 2.65e-01 0.194000 4.41e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 3.43e-02 0.193000 1.07e-01
Signaling by RAS mutants 40 3.43e-02 0.193000 1.07e-01
Signaling by moderate kinase activity BRAF mutants 40 3.43e-02 0.193000 1.07e-01
Signaling downstream of RAS mutants 40 3.43e-02 0.193000 1.07e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 8.28e-02 0.193000 2.01e-01
Innate Immune System 966 3.23e-24 0.193000 2.07e-21
Specification of primordial germ cells 6 4.14e-01 0.193000 5.89e-01
Hyaluronan uptake and degradation 12 2.48e-01 0.193000 4.22e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 1.02e-01 0.193000 2.33e-01
MET activates PTK2 signaling 21 1.27e-01 0.192000 2.69e-01
Formation of the cornified envelope 33 5.61e-02 0.192000 1.53e-01
RUNX3 regulates CDKN1A transcription 7 3.79e-01 -0.192000 5.56e-01
Maturation of nucleoprotein 9683610 11 2.70e-01 0.192000 4.45e-01
RHO GTPase cycle 408 3.20e-11 0.191000 3.84e-09
Signaling by Hedgehog 120 2.95e-04 0.191000 2.46e-03
CASP8 activity is inhibited 11 2.72e-01 -0.191000 4.46e-01
Dimerization of procaspase-8 11 2.72e-01 -0.191000 4.46e-01
Regulation by c-FLIP 11 2.72e-01 -0.191000 4.46e-01
FOXO-mediated transcription of cell death genes 16 1.86e-01 0.191000 3.46e-01
EPHA-mediated growth cone collapse 21 1.30e-01 0.191000 2.72e-01
Activation of PUMA and translocation to mitochondria 8 3.50e-01 -0.191000 5.25e-01
Interaction between L1 and Ankyrins 26 9.27e-02 0.190000 2.18e-01
GPER1 signaling 38 4.23e-02 0.190000 1.26e-01
Programmed Cell Death 186 7.75e-06 0.190000 1.42e-04
MAPK1/MAPK3 signaling 227 8.08e-07 0.190000 2.72e-05
RAB geranylgeranylation 62 9.69e-03 0.190000 4.18e-02
RNA Polymerase III Chain Elongation 18 1.63e-01 -0.190000 3.19e-01
Mitochondrial translation termination 90 1.85e-03 -0.190000 1.13e-02
Signaling by NTRKs 116 4.20e-04 0.190000 3.18e-03
PPARA activates gene expression 105 7.95e-04 0.189000 5.42e-03
Plasma lipoprotein assembly 10 3.00e-01 0.189000 4.74e-01
Interleukin-20 family signaling 17 1.77e-01 0.189000 3.35e-01
FGFR2 ligand binding and activation 9 3.26e-01 -0.189000 5.00e-01
CDC42 GTPase cycle 139 1.22e-04 0.189000 1.16e-03
Activation of G protein gated Potassium channels 18 1.66e-01 0.188000 3.22e-01
G protein gated Potassium channels 18 1.66e-01 0.188000 3.22e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 1.66e-01 0.188000 3.22e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 5.73e-02 0.188000 1.56e-01
ChREBP activates metabolic gene expression 7 3.88e-01 0.188000 5.64e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 2.86e-03 0.188000 1.58e-02
FOXO-mediated transcription of cell cycle genes 14 2.23e-01 0.188000 3.95e-01
Endogenous sterols 17 1.79e-01 0.188000 3.38e-01
FRS-mediated FGFR1 signaling 15 2.08e-01 0.188000 3.75e-01
DNA methylation 18 1.68e-01 0.188000 3.23e-01
Influenza Infection 154 6.02e-05 -0.187000 6.89e-04
MITF-M-regulated melanocyte development 110 6.95e-04 0.187000 4.82e-03
HS-GAG biosynthesis 19 1.58e-01 0.187000 3.12e-01
Nuclear Envelope (NE) Reassembly 68 7.83e-03 0.186000 3.54e-02
RAF/MAP kinase cascade 222 1.68e-06 0.186000 4.76e-05
STAT3 nuclear events downstream of ALK signaling 11 2.85e-01 0.186000 4.57e-01
Translation of Structural Proteins 9694635 55 1.70e-02 0.186000 6.55e-02
Switching of origins to a post-replicative state 79 4.27e-03 0.186000 2.15e-02
Signaling by TGFB family members 137 1.78e-04 0.185000 1.56e-03
Toll Like Receptor 3 (TLR3) Cascade 104 1.12e-03 0.185000 7.29e-03
TCR signaling 110 8.11e-04 0.185000 5.49e-03
Autophagy 142 1.44e-04 0.185000 1.33e-03
RET signaling 32 7.08e-02 0.185000 1.80e-01
Signaling by NOTCH1 66 9.61e-03 0.184000 4.16e-02
Assembly of the pre-replicative complex 87 2.97e-03 0.184000 1.63e-02
CLEC7A (Dectin-1) induces NFAT activation 11 2.90e-01 0.184000 4.64e-01
Signaling by NTRK3 (TRKC) 15 2.17e-01 0.184000 3.89e-01
Trafficking and processing of endosomal TLR 13 2.51e-01 0.184000 4.26e-01
Signaling by ALK fusions and activated point mutants 89 2.71e-03 0.184000 1.51e-02
Signaling by ALK in cancer 89 2.71e-03 0.184000 1.51e-02
G2/M DNA damage checkpoint 66 9.81e-03 0.184000 4.21e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 7.20e-02 0.184000 1.82e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 4.00e-01 0.184000 5.79e-01
Condensation of Prophase Chromosomes 27 9.89e-02 0.183000 2.27e-01
Complement cascade 100 1.53e-03 -0.183000 9.54e-03
MAPK targets/ Nuclear events mediated by MAP kinases 31 7.76e-02 0.183000 1.92e-01
PKA-mediated phosphorylation of CREB 17 1.91e-01 0.183000 3.54e-01
Platelet Aggregation (Plug Formation) 28 9.37e-02 0.183000 2.18e-01
Maturation of protein 3a 9683673 9 3.42e-01 0.183000 5.15e-01
Maturation of protein 3a 9694719 9 3.42e-01 0.183000 5.15e-01
NADE modulates death signalling 5 4.79e-01 0.183000 6.47e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 2.95e-01 -0.183000 4.68e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 1.93e-01 0.182000 3.55e-01
Diseases associated with the TLR signaling cascade 29 8.98e-02 0.182000 2.13e-01
Diseases of Immune System 29 8.98e-02 0.182000 2.13e-01
RND3 GTPase cycle 35 6.31e-02 0.182000 1.68e-01
Resolution of Sister Chromatid Cohesion 115 7.79e-04 0.181000 5.33e-03
Signaling by ALK 24 1.24e-01 0.181000 2.66e-01
Sphingolipid de novo biosynthesis 34 6.76e-02 0.181000 1.75e-01
Termination of translesion DNA synthesis 32 7.63e-02 -0.181000 1.90e-01
Anchoring fibril formation 7 4.08e-01 0.181000 5.85e-01
Glycogen synthesis 11 3.00e-01 0.181000 4.74e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.62e-01 0.180000 3.18e-01
Metabolic disorders of biological oxidation enzymes 23 1.34e-01 0.180000 2.78e-01
RHOU GTPase cycle 40 4.88e-02 0.180000 1.39e-01
Glycerophospholipid catabolism 6 4.45e-01 -0.180000 6.19e-01
Signaling by NTRK1 (TRKA) 102 1.70e-03 0.180000 1.04e-02
RHO GTPases activate CIT 18 1.87e-01 0.180000 3.48e-01
RUNX1 regulates estrogen receptor mediated transcription 6 4.46e-01 0.180000 6.19e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 3.03e-01 0.179000 4.77e-01
Nitric oxide stimulates guanylate cyclase 15 2.29e-01 0.179000 3.99e-01
Glycosphingolipid biosynthesis 16 2.14e-01 0.179000 3.85e-01
Maturation of spike protein 9694548 35 6.65e-02 0.179000 1.73e-01
Negative regulation of MAPK pathway 42 4.45e-02 0.179000 1.31e-01
Integration of energy metabolism 87 3.90e-03 0.179000 2.01e-02
Glucagon signaling in metabolic regulation 26 1.15e-01 0.179000 2.52e-01
Vesicle-mediated transport 663 4.18e-15 0.179000 1.00e-12
Mitochondrial translation 96 2.49e-03 -0.179000 1.42e-02
Inflammasomes 21 1.57e-01 0.178000 3.11e-01
Transcriptional regulation by RUNX2 87 4.04e-03 0.178000 2.06e-02
Vitamin B1 (thiamin) metabolism 5 4.90e-01 -0.178000 6.57e-01
Signaling by FGFR1 42 4.62e-02 0.178000 1.34e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 2.67e-01 0.178000 4.43e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 36 6.50e-02 0.178000 1.71e-01
Pre-NOTCH Processing in Golgi 18 1.92e-01 0.178000 3.54e-01
Signaling by BMP 23 1.41e-01 0.177000 2.88e-01
Macroautophagy 128 5.38e-04 0.177000 3.90e-03
Elevation of cytosolic Ca2+ levels 13 2.69e-01 0.177000 4.44e-01
Pre-NOTCH Expression and Processing 63 1.54e-02 0.176000 6.02e-02
Downstream TCR signaling 89 4.05e-03 0.176000 2.06e-02
Regulation of localization of FOXO transcription factors 11 3.12e-01 0.176000 4.89e-01
Synthesis of PI 5 4.96e-01 -0.176000 6.62e-01
Apoptosis induced DNA fragmentation 10 3.37e-01 0.175000 5.10e-01
HATs acetylate histones 92 3.75e-03 0.175000 1.94e-02
Defective C1GALT1C1 causes TNPS 9 3.64e-01 0.175000 5.38e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 2.57e-01 -0.175000 4.32e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.49e-01 0.174000 2.97e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 4.61e-01 0.174000 6.31e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 4.61e-01 0.174000 6.31e-01
Glutathione conjugation 26 1.26e-01 0.174000 2.68e-01
Interleukin receptor SHC signaling 23 1.50e-01 0.173000 2.99e-01
Apoptosis 157 1.78e-04 0.173000 1.56e-03
Oxidative Stress Induced Senescence 77 8.55e-03 0.173000 3.79e-02
TGFBR3 PTM regulation 10 3.44e-01 0.173000 5.17e-01
SHC-mediated cascade:FGFR4 11 3.22e-01 0.173000 4.95e-01
Regulation of lipid metabolism by PPARalpha 107 2.04e-03 0.173000 1.22e-02
Acetylcholine Neurotransmitter Release Cycle 11 3.23e-01 -0.172000 4.96e-01
TYSND1 cleaves peroxisomal proteins 7 4.30e-01 0.172000 6.06e-01
Regulation of Complement cascade 96 3.57e-03 -0.172000 1.87e-02
PIP3 activates AKT signaling 232 6.44e-06 0.172000 1.26e-04
Small interfering RNA (siRNA) biogenesis 9 3.72e-01 0.172000 5.48e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.23e-01 0.172000 2.65e-01
Cyclin D associated events in G1 47 4.23e-02 0.171000 1.26e-01
G1 Phase 47 4.23e-02 0.171000 1.26e-01
G2/M Transition 177 8.97e-05 0.171000 9.22e-04
IL-6-type cytokine receptor ligand interactions 12 3.06e-01 0.171000 4.82e-01
CD28 dependent PI3K/Akt signaling 22 1.66e-01 -0.171000 3.22e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 3.28e-01 -0.170000 5.02e-01
Mitotic G2-G2/M phases 179 8.58e-05 0.170000 9.01e-04
Heme biosynthesis 13 2.89e-01 -0.170000 4.62e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.34e-01 0.170000 2.77e-01
Cell-extracellular matrix interactions 15 2.55e-01 0.170000 4.31e-01
Estrogen-stimulated signaling through PRKCZ 6 4.72e-01 0.170000 6.42e-01
N-glycan trimming and elongation in the cis-Golgi 5 5.13e-01 0.169000 6.73e-01
Mitochondrial tRNA aminoacylation 21 1.80e-01 -0.169000 3.40e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 1.44e-01 0.169000 2.92e-01
Activation of ATR in response to replication stress 37 7.63e-02 -0.168000 1.90e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 3.13e-01 -0.168000 4.89e-01
SHC-mediated cascade:FGFR2 13 2.94e-01 0.168000 4.68e-01
Metal ion SLC transporters 19 2.04e-01 0.168000 3.70e-01
Selective autophagy 77 1.08e-02 0.168000 4.53e-02
Regulation of MITF-M-dependent genes involved in pigmentation 35 8.58e-02 0.168000 2.06e-01
CD28 dependent Vav1 pathway 12 3.15e-01 0.168000 4.91e-01
Signaling by FGFR in disease 52 3.67e-02 0.167000 1.12e-01
Calcineurin activates NFAT 9 3.84e-01 0.167000 5.61e-01
Crosslinking of collagen fibrils 12 3.15e-01 -0.167000 4.91e-01
ROBO receptors bind AKAP5 7 4.43e-01 0.167000 6.18e-01
Synthesis of PC 23 1.65e-01 0.167000 3.22e-01
Chaperonin-mediated protein folding 77 1.14e-02 0.167000 4.78e-02
Epigenetic regulation by WDR5-containing histone modifying complexes 117 1.83e-03 0.167000 1.12e-02
MHC class II antigen presentation 113 2.20e-03 0.167000 1.29e-02
Rab regulation of trafficking 122 1.47e-03 0.167000 9.23e-03
Zinc transporters 12 3.18e-01 0.167000 4.94e-01
Keratinization 34 9.33e-02 0.166000 2.18e-01
Miscellaneous transport and binding events 20 1.98e-01 0.166000 3.63e-01
Chromatin modifying enzymes 213 3.10e-05 0.166000 4.20e-04
Chromatin organization 213 3.10e-05 0.166000 4.20e-04
Signaling by Nuclear Receptors 210 3.81e-05 0.165000 4.82e-04
M Phase 345 1.43e-07 0.165000 7.15e-06
Fanconi Anemia Pathway 36 8.71e-02 -0.165000 2.08e-01
HS-GAG degradation 18 2.27e-01 -0.165000 3.99e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 4.44e-02 0.164000 1.31e-01
Triglyceride metabolism 24 1.64e-01 0.164000 3.19e-01
Signaling by Non-Receptor Tyrosine Kinases 47 5.17e-02 0.164000 1.45e-01
Signaling by PTK6 47 5.17e-02 0.164000 1.45e-01
Phospholipase C-mediated cascade: FGFR1 8 4.22e-01 -0.164000 5.99e-01
Class I peroxisomal membrane protein import 20 2.05e-01 -0.164000 3.71e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 3.45e-02 0.163000 1.07e-01
HSF1 activation 25 1.58e-01 0.163000 3.12e-01
Regulation of PTEN mRNA translation 12 3.28e-01 0.163000 5.02e-01
Ubiquinol biosynthesis 13 3.09e-01 -0.163000 4.85e-01
Glycosphingolipid transport 7 4.55e-01 -0.163000 6.25e-01
Regulation of insulin secretion 62 2.68e-02 0.163000 9.04e-02
Blood group systems biosynthesis 16 2.60e-01 -0.163000 4.35e-01
Protein methylation 15 2.76e-01 -0.163000 4.49e-01
RIP-mediated NFkB activation via ZBP1 17 2.46e-01 0.162000 4.21e-01
PTEN Regulation 126 1.65e-03 0.162000 1.02e-02
Phosphorylation of Emi1 6 4.92e-01 -0.162000 6.58e-01
Signaling by ERBB2 TMD/JMD mutants 17 2.48e-01 0.162000 4.22e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 4.94e-01 -0.161000 6.60e-01
Insulin receptor signalling cascade 40 7.75e-02 0.161000 1.92e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.90e-01 0.161000 3.53e-01
Carnitine shuttle 12 3.34e-01 -0.161000 5.08e-01
Intracellular signaling by second messengers 264 6.73e-06 0.161000 1.27e-04
Telomere C-strand synthesis initiation 13 3.15e-01 -0.161000 4.91e-01
Activation of GABAB receptors 29 1.34e-01 0.161000 2.78e-01
GABA B receptor activation 29 1.34e-01 0.161000 2.78e-01
HDACs deacetylate histones 45 6.27e-02 0.160000 1.67e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.42e-01 0.160000 2.89e-01
Hemostasis 553 1.25e-10 0.160000 1.27e-08
A tetrasaccharide linker sequence is required for GAG synthesis 16 2.68e-01 -0.160000 4.44e-01
p38MAPK events 13 3.18e-01 0.160000 4.94e-01
Integrin signaling 22 1.95e-01 0.160000 3.57e-01
Acyl chain remodelling of PC 19 2.28e-01 0.160000 3.99e-01
Synthesis of PIPs at the Golgi membrane 16 2.69e-01 0.160000 4.44e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 1.22e-02 -0.159000 5.00e-02
Gluconeogenesis 19 2.31e-01 0.159000 4.01e-01
Glutamate and glutamine metabolism 12 3.42e-01 -0.159000 5.15e-01
Defective LFNG causes SCDO3 5 5.40e-01 0.158000 6.98e-01
OAS antiviral response 8 4.38e-01 -0.158000 6.15e-01
Regulation of FZD by ubiquitination 15 2.89e-01 0.158000 4.63e-01
Translesion Synthesis by POLH 18 2.46e-01 -0.158000 4.21e-01
Muscle contraction 142 1.18e-03 0.158000 7.60e-03
Kinesins 51 5.20e-02 0.157000 1.46e-01
Activation of the phototransduction cascade 8 4.44e-01 0.156000 6.18e-01
The canonical retinoid cycle in rods (twilight vision) 9 4.18e-01 -0.156000 5.94e-01
Biosynthesis of EPA-derived SPMs 6 5.09e-01 0.156000 6.73e-01
RNA Polymerase II Pre-transcription Events 77 1.83e-02 0.156000 6.84e-02
Keratan sulfate/keratin metabolism 27 1.62e-01 0.155000 3.18e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 3.15e-01 0.155000 4.91e-01
Asparagine N-linked glycosylation 284 7.29e-06 0.155000 1.35e-04
Signal Transduction 2034 1.56e-30 0.154000 1.50e-27
VEGFR2 mediated cell proliferation 18 2.57e-01 0.154000 4.32e-01
PECAM1 interactions 12 3.55e-01 0.154000 5.28e-01
Sperm Motility And Taxes 6 5.13e-01 -0.154000 6.73e-01
Formation of ATP by chemiosmotic coupling 20 2.33e-01 0.154000 4.04e-01
Synthesis of PE 12 3.56e-01 -0.154000 5.29e-01
Integrin cell surface interactions 64 3.33e-02 0.154000 1.05e-01
RAF-independent MAPK1/3 activation 21 2.22e-01 0.154000 3.95e-01
Signaling by NODAL 15 3.03e-01 0.154000 4.77e-01
Complex III assembly 23 2.04e-01 -0.153000 3.70e-01
FCGR3A-mediated IL10 synthesis 99 8.55e-03 -0.153000 3.79e-02
Disorders of transmembrane transporters 134 2.24e-03 0.153000 1.31e-02
Cellular Senescence 142 1.67e-03 0.153000 1.03e-02
Metabolism of steroids 120 4.04e-03 0.152000 2.06e-02
E2F-enabled inhibition of pre-replication complex formation 9 4.30e-01 0.152000 6.06e-01
Degradation of the extracellular matrix 92 1.19e-02 0.152000 4.97e-02
Negative regulation of the PI3K/AKT network 91 1.25e-02 0.152000 5.10e-02
RNA Polymerase I Transcription Initiation 47 7.23e-02 -0.152000 1.82e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.80e-01 0.151000 4.53e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.80e-01 0.151000 4.53e-01
Cell Cycle Checkpoints 245 4.49e-05 0.151000 5.46e-04
Defective GALNT3 causes HFTC 8 4.60e-01 0.151000 6.30e-01
SARS-CoV-2 modulates autophagy 11 3.87e-01 0.151000 5.63e-01
Non-integrin membrane-ECM interactions 46 7.73e-02 0.151000 1.92e-01
FCERI mediated Ca+2 mobilization 92 1.32e-02 -0.150000 5.34e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 4.38e-01 -0.149000 6.15e-01
Physiological factors 9 4.38e-01 0.149000 6.15e-01
Cellular response to mitochondrial stress 9 4.39e-01 0.149000 6.15e-01
Effects of PIP2 hydrolysis 24 2.07e-01 -0.149000 3.74e-01
CD209 (DC-SIGN) signaling 20 2.50e-01 0.149000 4.25e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 5.29e-01 -0.148000 6.87e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.83e-01 -0.148000 3.43e-01
RNA Polymerase III Transcription Termination 22 2.30e-01 -0.148000 3.99e-01
Prevention of phagosomal-lysosomal fusion 9 4.42e-01 0.148000 6.18e-01
NOD1/2 Signaling Pathway 36 1.25e-01 0.148000 2.66e-01
Glucuronidation 8 4.69e-01 0.148000 6.39e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 5.51e-02 0.147000 1.52e-01
Surfactant metabolism 20 2.56e-01 0.147000 4.31e-01
Cellular responses to stimuli 776 4.13e-12 0.146000 6.61e-10
Post-chaperonin tubulin folding pathway 18 2.83e-01 0.146000 4.56e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 5.72e-01 0.146000 7.25e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 5.73e-01 -0.146000 7.26e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 6.65e-02 0.146000 1.73e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 6.65e-02 0.146000 1.73e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 6.65e-02 0.146000 1.73e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 6.65e-02 0.146000 1.73e-01
Signaling by NOTCH1 in Cancer 53 6.65e-02 0.146000 1.73e-01
ZBP1(DAI) mediated induction of type I IFNs 20 2.60e-01 0.146000 4.34e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 3.14e-01 0.145000 4.90e-01
PKA activation in glucagon signalling 14 3.46e-01 0.145000 5.20e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 4.26e-01 0.145000 6.03e-01
Mitotic G1 phase and G1/S transition 138 3.23e-03 0.145000 1.72e-02
Chemokine receptors bind chemokines 39 1.17e-01 0.145000 2.56e-01
Interactions of Vpr with host cellular proteins 37 1.28e-01 -0.145000 2.69e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 5.09e-01 0.144000 6.73e-01
Signaling by ERBB2 44 9.84e-02 0.144000 2.27e-01
Protein folding 83 2.33e-02 0.144000 8.24e-02
Phospholipid metabolism 182 8.11e-04 0.144000 5.49e-03
G beta:gamma signalling through PI3Kgamma 22 2.43e-01 0.144000 4.17e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 5.61e-02 -0.144000 1.53e-01
Synthesis of PG 8 4.82e-01 -0.144000 6.49e-01
PRC2 methylates histones and DNA 27 1.97e-01 0.143000 3.61e-01
Endosomal/Vacuolar pathway 11 4.11e-01 0.143000 5.87e-01
Post-transcriptional silencing by small RNAs 7 5.12e-01 0.143000 6.73e-01
Senescence-Associated Secretory Phenotype (SASP) 64 4.80e-02 0.143000 1.38e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 3.73e-01 0.143000 5.50e-01
Translation 293 2.72e-05 -0.142000 3.82e-04
Activation of Ca-permeable Kainate Receptor 8 4.86e-01 -0.142000 6.52e-01
Ionotropic activity of kainate receptors 8 4.86e-01 -0.142000 6.52e-01
Attachment and Entry 9694614 13 3.74e-01 0.142000 5.50e-01
Extra-nuclear estrogen signaling 65 4.75e-02 0.142000 1.37e-01
IkBA variant leads to EDA-ID 7 5.16e-01 0.142000 6.75e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 1.42e-01 -0.141000 2.89e-01
Translation initiation complex formation 58 6.28e-02 -0.141000 1.67e-01
Sialic acid metabolism 27 2.04e-01 0.141000 3.70e-01
Ovarian tumor domain proteases 37 1.37e-01 0.141000 2.83e-01
Ion channel transport 136 4.63e-03 0.141000 2.28e-02
Notch-HLH transcription pathway 28 1.99e-01 0.140000 3.63e-01
Mitotic Prophase 96 1.76e-02 0.140000 6.70e-02
BBSome-mediated cargo-targeting to cilium 23 2.45e-01 -0.140000 4.19e-01
Regulation of NPAS4 gene expression 11 4.22e-01 0.140000 5.98e-01
Binding and Uptake of Ligands by Scavenger Receptors 90 2.19e-02 -0.140000 7.93e-02
p75NTR signals via NF-kB 15 3.49e-01 0.140000 5.23e-01
Cristae formation 33 1.66e-01 0.139000 3.22e-01
Suppression of phagosomal maturation 12 4.04e-01 0.139000 5.83e-01
VEGF binds to VEGFR leading to receptor dimerization 5 5.90e-01 0.139000 7.40e-01
VEGF ligand-receptor interactions 5 5.90e-01 0.139000 7.40e-01
PI3K/AKT Signaling in Cancer 83 2.87e-02 0.139000 9.47e-02
Signaling by KIT in disease 20 2.83e-01 0.139000 4.56e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.83e-01 0.139000 4.56e-01
Regulation of TP53 Activity through Methylation 19 2.96e-01 -0.138000 4.71e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 5.26e-01 0.138000 6.86e-01
Beta-oxidation of pristanoyl-CoA 9 4.73e-01 0.138000 6.42e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 1.02e-01 0.138000 2.32e-01
B-WICH complex positively regulates rRNA expression 45 1.10e-01 0.138000 2.45e-01
IRS-related events triggered by IGF1R 36 1.53e-01 0.138000 3.04e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 5.95e-01 -0.137000 7.41e-01
Amine ligand-binding receptors 10 4.52e-01 0.137000 6.24e-01
Inhibition of DNA recombination at telomere 33 1.73e-01 0.137000 3.30e-01
Tandem pore domain potassium channels 5 5.97e-01 0.137000 7.42e-01
Gamma-carboxylation of protein precursors 6 5.63e-01 -0.136000 7.17e-01
Acyl chain remodelling of PG 11 4.34e-01 0.136000 6.10e-01
HIV Infection 213 6.32e-04 0.136000 4.46e-03
Class I MHC mediated antigen processing & presentation 343 1.62e-05 0.136000 2.61e-04
Sensory perception of taste 23 2.62e-01 -0.135000 4.37e-01
SIRT1 negatively regulates rRNA expression 22 2.73e-01 0.135000 4.47e-01
Metabolism of steroid hormones 21 2.85e-01 0.135000 4.58e-01
IRS-mediated signalling 35 1.68e-01 0.135000 3.23e-01
Transport and synthesis of PAPS 6 5.68e-01 0.134000 7.23e-01
Passive transport by Aquaporins 6 5.69e-01 0.134000 7.23e-01
FCERI mediated MAPK activation 93 2.51e-02 -0.134000 8.65e-02
Transcriptional regulation of white adipocyte differentiation 77 4.18e-02 0.134000 1.25e-01
rRNA processing in the mitochondrion 24 2.55e-01 0.134000 4.31e-01
Defective pyroptosis 27 2.28e-01 0.134000 3.99e-01
TAK1-dependent IKK and NF-kappa-B activation 43 1.29e-01 0.134000 2.70e-01
Amyloid fiber formation 51 9.96e-02 0.133000 2.28e-01
Coenzyme A biosynthesis 7 5.43e-01 -0.133000 7.02e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.10e-01 0.132000 5.87e-01
Regulation of BACH1 activity 11 4.50e-01 0.132000 6.21e-01
ERKs are inactivated 13 4.11e-01 0.132000 5.88e-01
FLT3 signaling through SRC family kinases 6 5.77e-01 0.131000 7.30e-01
Ca-dependent events 29 2.21e-01 0.131000 3.94e-01
NR1H2 and NR1H3-mediated signaling 38 1.62e-01 0.131000 3.18e-01
Neurotransmitter receptors and postsynaptic signal transmission 132 9.33e-03 0.131000 4.09e-02
G-protein beta:gamma signalling 29 2.22e-01 0.131000 3.94e-01
FGFR1 ligand binding and activation 10 4.74e-01 -0.131000 6.42e-01
Cellular responses to stress 694 5.00e-09 0.130000 3.55e-07
EML4 and NUDC in mitotic spindle formation 106 2.07e-02 0.130000 7.61e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.34e-01 -0.130000 4.04e-01
tRNA processing in the nucleus 59 8.42e-02 -0.130000 2.02e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.77e-01 0.130000 6.45e-01
Meiotic synapsis 43 1.41e-01 0.130000 2.89e-01
Retinoid metabolism and transport 23 2.83e-01 0.129000 4.56e-01
IGF1R signaling cascade 37 1.73e-01 0.129000 3.30e-01
Activation of BAD and translocation to mitochondria 15 3.86e-01 0.129000 5.62e-01
Phospholipase C-mediated cascade; FGFR4 6 5.84e-01 -0.129000 7.35e-01
Signalling to RAS 19 3.31e-01 0.129000 5.06e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 5.55e-01 0.129000 7.14e-01
MTOR signalling 39 1.65e-01 0.128000 3.22e-01
Ribosomal scanning and start codon recognition 58 9.13e-02 -0.128000 2.15e-01
Defective Intrinsic Pathway for Apoptosis 24 2.77e-01 0.128000 4.52e-01
Nucleotide-like (purinergic) receptors 14 4.09e-01 0.128000 5.85e-01
Immune System 1828 2.03e-19 0.127000 7.79e-17
RIPK1-mediated regulated necrosis 31 2.21e-01 0.127000 3.93e-01
Regulation of necroptotic cell death 31 2.21e-01 0.127000 3.93e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 3.14e-01 0.127000 4.90e-01
Cytokine Signaling in Immune system 662 2.64e-08 0.127000 1.51e-06
Miscellaneous substrates 7 5.63e-01 0.126000 7.17e-01
G-protein mediated events 43 1.52e-01 0.126000 3.03e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.97e-01 0.126000 4.71e-01
Developmental Biology 906 1.45e-10 0.126000 1.39e-08
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 183 3.39e-03 -0.126000 1.80e-02
Interleukin-1 processing 8 5.39e-01 -0.126000 6.97e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 3.20e-01 0.125000 4.94e-01
Respiratory Syncytial Virus Infection Pathway 97 3.31e-02 0.125000 1.05e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 5.96e-01 0.125000 7.41e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.19e-01 -0.125000 2.60e-01
Biosynthesis of E-series 18(S)-resolvins 5 6.29e-01 0.125000 7.65e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.43e-02 0.125000 1.31e-01
Prostacyclin signalling through prostacyclin receptor 16 3.89e-01 0.124000 5.65e-01
Interleukin-2 signaling 11 4.76e-01 0.124000 6.45e-01
Impaired BRCA2 binding to RAD51 35 2.04e-01 0.124000 3.70e-01
Ion transport by P-type ATPases 41 1.70e-01 0.124000 3.25e-01
IRE1alpha activates chaperones 46 1.46e-01 0.124000 2.95e-01
Formation of axial mesoderm 6 6.01e-01 0.123000 7.46e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.80e-01 -0.123000 5.57e-01
AMPK inhibits chREBP transcriptional activation activity 6 6.03e-01 0.123000 7.46e-01
Killing mechanisms 9 5.28e-01 -0.122000 6.87e-01
WNT5:FZD7-mediated leishmania damping 9 5.28e-01 -0.122000 6.87e-01
Signaling by FGFR2 in disease 33 2.27e-01 0.121000 3.99e-01
RNA polymerase II transcribes snRNA genes 71 7.70e-02 0.121000 1.91e-01
Defective factor IX causes hemophilia B 6 6.07e-01 0.121000 7.50e-01
Processing of DNA double-strand break ends 69 8.24e-02 0.121000 2.00e-01
Oncogene Induced Senescence 33 2.29e-01 0.121000 3.99e-01
Hyaluronan metabolism 15 4.18e-01 0.121000 5.94e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.69e-01 -0.121000 4.44e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 2.70e-01 0.121000 4.44e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 4.19e-01 0.120000 5.95e-01
G alpha (s) signalling events 93 4.48e-02 0.120000 1.31e-01
G0 and Early G1 27 2.79e-01 0.120000 4.53e-01
Type I hemidesmosome assembly 8 5.56e-01 0.120000 7.14e-01
Regulated Necrosis 55 1.23e-01 0.120000 2.65e-01
RUNX3 regulates WNT signaling 8 5.56e-01 0.120000 7.14e-01
Cell Cycle, Mitotic 487 5.80e-06 0.120000 1.16e-04
Striated Muscle Contraction 25 2.99e-01 0.120000 4.73e-01
Transport of small molecules 548 1.59e-06 0.120000 4.63e-05
Host Interactions of HIV factors 118 2.48e-02 0.120000 8.55e-02
Modulation by Mtb of host immune system 7 5.84e-01 0.119000 7.35e-01
Signaling by FGFR2 61 1.08e-01 0.119000 2.43e-01
RNA Polymerase I Transcription Termination 30 2.59e-01 -0.119000 4.34e-01
HIV Transcription Initiation 45 1.68e-01 0.119000 3.22e-01
RNA Polymerase II HIV Promoter Escape 45 1.68e-01 0.119000 3.22e-01
RNA Polymerase II Promoter Escape 45 1.68e-01 0.119000 3.22e-01
RNA Polymerase II Transcription Initiation 45 1.68e-01 0.119000 3.22e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.68e-01 0.119000 3.22e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.68e-01 0.119000 3.22e-01
Mitotic Prometaphase 192 4.53e-03 0.119000 2.25e-02
Response of Mtb to phagocytosis 22 3.36e-01 0.119000 5.09e-01
mRNA Editing 8 5.62e-01 0.118000 7.17e-01
Regulation of RUNX1 Expression and Activity 18 3.86e-01 0.118000 5.62e-01
Formation of RNA Pol II elongation complex 56 1.27e-01 0.118000 2.69e-01
RNA Polymerase II Transcription Elongation 56 1.27e-01 0.118000 2.69e-01
Molecules associated with elastic fibres 26 2.99e-01 0.118000 4.73e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 4.99e-01 -0.118000 6.65e-01
Metabolism of Angiotensinogen to Angiotensins 12 4.80e-01 0.118000 6.48e-01
Nuclear signaling by ERBB4 24 3.20e-01 0.117000 4.94e-01
Defective B4GALT7 causes EDS, progeroid type 10 5.21e-01 -0.117000 6.80e-01
Plasma lipoprotein clearance 33 2.45e-01 0.117000 4.19e-01
RHO GTPases Activate Formins 127 2.28e-02 0.117000 8.15e-02
Nicotinamide salvaging 15 4.34e-01 0.117000 6.10e-01
Telomere Extension By Telomerase 23 3.34e-01 0.116000 5.08e-01
RSK activation 7 5.94e-01 0.116000 7.41e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 2.57e-01 0.116000 4.32e-01
Axon guidance 455 2.31e-05 0.116000 3.36e-04
RAS processing 23 3.37e-01 0.116000 5.09e-01
PKR-mediated signaling 67 1.02e-01 0.116000 2.32e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 2.18e-01 0.115000 3.90e-01
Early Phase of HIV Life Cycle 14 4.55e-01 -0.115000 6.25e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.90e-01 0.115000 6.56e-01
G beta:gamma signalling through PLC beta 17 4.12e-01 0.115000 5.88e-01
Presynaptic function of Kainate receptors 17 4.12e-01 0.115000 5.88e-01
PKMTs methylate histone lysines 42 1.98e-01 0.115000 3.61e-01
Adenylate cyclase inhibitory pathway 11 5.10e-01 0.115000 6.73e-01
DNA Replication Pre-Initiation 103 4.43e-02 0.115000 1.31e-01
Translation of Structural Proteins 9683701 29 2.85e-01 0.115000 4.58e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 6.58e-01 -0.114000 7.92e-01
RUNX2 regulates osteoblast differentiation 16 4.29e-01 -0.114000 6.06e-01
Ribavirin ADME 11 5.12e-01 0.114000 6.73e-01
G1/S Transition 120 3.09e-02 0.114000 9.95e-02
Cardiogenesis 13 4.77e-01 -0.114000 6.45e-01
Interleukin-21 signaling 9 5.56e-01 0.113000 7.14e-01
Class A/1 (Rhodopsin-like receptors) 176 9.59e-03 0.113000 4.16e-02
Bicarbonate transporters 9 5.57e-01 0.113000 7.15e-01
G alpha (q) signalling events 139 2.15e-02 0.113000 7.86e-02
Nervous system development 473 2.62e-05 0.113000 3.72e-04
VEGFR2 mediated vascular permeability 26 3.21e-01 0.112000 4.95e-01
Protein localization 157 1.52e-02 -0.112000 5.95e-02
PLC beta mediated events 39 2.26e-01 0.112000 3.99e-01
Cell-Cell communication 108 4.48e-02 0.112000 1.31e-01
Transcription of the HIV genome 67 1.14e-01 0.112000 2.51e-01
Transcriptional Regulation by MECP2 47 1.85e-01 0.112000 3.46e-01
Elastic fibre formation 33 2.68e-01 0.111000 4.44e-01
Sphingolipid metabolism 92 6.52e-02 0.111000 1.71e-01
Activation of HOX genes during differentiation 68 1.13e-01 0.111000 2.50e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 1.13e-01 0.111000 2.50e-01
Ion homeostasis 40 2.24e-01 0.111000 3.95e-01
DNA Double Strand Break Response 47 1.88e-01 0.111000 3.49e-01
Mitochondrial iron-sulfur cluster biogenesis 13 4.88e-01 -0.111000 6.55e-01
Extracellular matrix organization 213 5.29e-03 0.111000 2.56e-02
Pyroptosis 24 3.48e-01 0.111000 5.22e-01
HCMV Late Events 67 1.17e-01 0.111000 2.57e-01
Dual Incision in GG-NER 41 2.21e-01 -0.111000 3.94e-01
Diseases associated with O-glycosylation of proteins 46 1.95e-01 -0.110000 3.58e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 1.96e-01 0.110000 3.59e-01
HCMV Infection 106 5.08e-02 0.110000 1.43e-01
Regulation of HSF1-mediated heat shock response 78 9.37e-02 0.110000 2.18e-01
Acetylcholine regulates insulin secretion 9 5.69e-01 0.110000 7.23e-01
Disorders of Developmental Biology 12 5.11e-01 0.110000 6.73e-01
Disorders of Nervous System Development 12 5.11e-01 0.110000 6.73e-01
Loss of function of MECP2 in Rett syndrome 12 5.11e-01 0.110000 6.73e-01
Pervasive developmental disorders 12 5.11e-01 0.110000 6.73e-01
Infection with Mycobacterium tuberculosis 26 3.35e-01 0.109000 5.08e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 4.23e-01 0.109000 5.99e-01
Nucleotide catabolism 29 3.10e-01 0.109000 4.86e-01
NRIF signals cell death from the nucleus 15 4.65e-01 0.109000 6.35e-01
Regulation of TP53 Activity through Phosphorylation 88 7.75e-02 0.109000 1.92e-01
CRMPs in Sema3A signaling 13 4.98e-01 0.108000 6.64e-01
Phase I - Functionalization of compounds 62 1.41e-01 0.108000 2.89e-01
HDL remodeling 6 6.47e-01 -0.108000 7.82e-01
TRAF3-dependent IRF activation pathway 13 5.00e-01 -0.108000 6.66e-01
p75 NTR receptor-mediated signalling 89 7.87e-02 0.108000 1.93e-01
Lewis blood group biosynthesis 13 5.02e-01 -0.108000 6.67e-01
Post-translational protein modification 1232 2.32e-10 0.107000 2.03e-08
Arachidonate metabolism 42 2.29e-01 0.107000 3.99e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.54e-01 -0.107000 4.30e-01
Glycolysis 68 1.28e-01 0.107000 2.69e-01
Purine salvage 12 5.22e-01 0.107000 6.81e-01
Metabolism of lipids 632 5.37e-06 0.106000 1.13e-04
Mitochondrial biogenesis 91 8.06e-02 0.106000 1.97e-01
Synthesis of PIPs at the ER membrane 5 6.82e-01 -0.106000 8.11e-01
PI3K Cascade 31 3.08e-01 0.106000 4.84e-01
CS/DS degradation 9 5.83e-01 -0.106000 7.35e-01
SLBP independent Processing of Histone Pre-mRNAs 10 5.63e-01 -0.106000 7.17e-01
Meiotic recombination 36 2.73e-01 0.106000 4.47e-01
AKT phosphorylates targets in the nucleus 9 5.84e-01 -0.105000 7.35e-01
Role of second messengers in netrin-1 signaling 6 6.55e-01 -0.105000 7.90e-01
Nicotinate metabolism 26 3.53e-01 0.105000 5.26e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 4.96e-01 0.105000 6.62e-01
SHC-mediated cascade:FGFR1 13 5.12e-01 0.105000 6.73e-01
Fc epsilon receptor (FCERI) signaling 179 1.56e-02 0.105000 6.06e-02
Transcriptional Regulation by TP53 343 8.78e-04 0.105000 5.90e-03
NCAM1 interactions 26 3.58e-01 -0.104000 5.30e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 5.16e-01 -0.104000 6.75e-01
Cell Cycle 609 1.17e-05 0.104000 1.96e-04
ECM proteoglycans 45 2.28e-01 0.104000 3.99e-01
Loss of Function of TGFBR1 in Cancer 7 6.35e-01 0.104000 7.70e-01
TRAIL signaling 8 6.13e-01 -0.103000 7.53e-01
PINK1-PRKN Mediated Mitophagy 31 3.19e-01 0.103000 4.94e-01
Glucose metabolism 76 1.19e-01 0.103000 2.60e-01
Nucleotide salvage 21 4.13e-01 0.103000 5.89e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 5.38e-01 0.103000 6.96e-01
Transcriptional regulation of testis differentiation 5 6.91e-01 -0.103000 8.20e-01
Regulation of NF-kappa B signaling 18 4.52e-01 -0.102000 6.24e-01
XBP1(S) activates chaperone genes 44 2.41e-01 0.102000 4.15e-01
Removal of the Flap Intermediate from the C-strand 17 4.67e-01 -0.102000 6.36e-01
TGFBR3 regulates TGF-beta signaling 8 6.18e-01 -0.102000 7.57e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 10 5.79e-01 -0.101000 7.32e-01
Interferon alpha/beta signaling 63 1.64e-01 -0.101000 3.20e-01
Adipogenesis 95 8.92e-02 0.101000 2.12e-01
RHOV GTPase cycle 36 2.97e-01 0.100000 4.71e-01
ABC transporters in lipid homeostasis 14 5.16e-01 -0.100000 6.75e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 90 1.00e-01 0.100000 2.29e-01
Amplification of signal from the kinetochores 90 1.00e-01 0.100000 2.29e-01
Cellular response to starvation 148 3.55e-02 -0.100000 1.10e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 6.04e-01 0.099900 7.47e-01
Stimuli-sensing channels 78 1.28e-01 0.099600 2.70e-01
Vpr-mediated nuclear import of PICs 34 3.19e-01 -0.098700 4.94e-01
Extension of Telomeres 51 2.23e-01 -0.098700 3.95e-01
Regulation of CDH11 gene transcription 5 7.03e-01 -0.098400 8.30e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.08e-01 0.097600 5.85e-01
Pyruvate metabolism 44 2.62e-01 0.097600 4.38e-01
Pregnenolone biosynthesis 10 5.93e-01 -0.097500 7.41e-01
Mitotic Spindle Checkpoint 107 8.22e-02 0.097300 2.00e-01
G alpha (i) signalling events 196 1.89e-02 0.097200 7.06e-02
mRNA Splicing - Major Pathway 203 1.71e-02 0.097100 6.58e-02
Meiosis 66 1.73e-01 0.096900 3.30e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 3.84e-01 0.096800 5.61e-01
Cellular response to heat stress 92 1.09e-01 0.096600 2.44e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 20 4.55e-01 -0.096600 6.25e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 4.55e-01 0.096500 6.25e-01
Reproduction 84 1.27e-01 0.096300 2.69e-01
RNA Polymerase III Transcription Initiation 36 3.18e-01 -0.096200 4.94e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 6.08e-03 0.096100 2.90e-02
Late Phase of HIV Life Cycle 131 5.83e-02 0.095800 1.58e-01
ERK/MAPK targets 22 4.37e-01 0.095800 6.14e-01
Citric acid cycle (TCA cycle) 34 3.34e-01 0.095700 5.08e-01
Keratan sulfate degradation 9 6.19e-01 0.095700 7.58e-01
Zinc influx into cells by the SLC39 gene family 9 6.20e-01 0.095600 7.58e-01
Receptor-type tyrosine-protein phosphatases 11 5.83e-01 0.095600 7.35e-01
Amino acid transport across the plasma membrane 24 4.19e-01 -0.095300 5.95e-01
Unfolded Protein Response (UPR) 84 1.32e-01 0.095200 2.74e-01
TBC/RABGAPs 45 2.70e-01 0.095100 4.44e-01
TRIF-mediated programmed cell death 9 6.21e-01 0.095100 7.59e-01
Fatty acyl-CoA biosynthesis 35 3.31e-01 0.094900 5.06e-01
Deadenylation-dependent mRNA decay 50 2.47e-01 0.094600 4.21e-01
Nuclear Events (kinase and transcription factor activation) 54 2.29e-01 0.094600 3.99e-01
Termination of O-glycan biosynthesis 15 5.28e-01 0.094100 6.87e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 5.32e-01 0.093300 6.89e-01
RND1 GTPase cycle 36 3.35e-01 0.092900 5.08e-01
HCMV Early Events 84 1.42e-01 0.092700 2.89e-01
Synaptic adhesion-like molecules 14 5.49e-01 -0.092500 7.08e-01
CaM pathway 27 4.07e-01 0.092200 5.84e-01
Calmodulin induced events 27 4.07e-01 0.092200 5.84e-01
Loss of Nlp from mitotic centrosomes 69 1.85e-01 0.092200 3.46e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 1.85e-01 0.092200 3.46e-01
Propionyl-CoA catabolism 5 7.21e-01 -0.092100 8.44e-01
Retrograde neurotrophin signalling 12 5.82e-01 0.091700 7.35e-01
Translesion synthesis by POLI 17 5.15e-01 -0.091200 6.75e-01
Defects in cobalamin (B12) metabolism 13 5.69e-01 -0.091100 7.23e-01
Signaling by Retinoic Acid 29 3.96e-01 -0.091000 5.74e-01
Translesion synthesis by REV1 16 5.29e-01 -0.091000 6.87e-01
Signaling by FGFR 73 1.79e-01 0.090900 3.38e-01
Activation of NMDA receptors and postsynaptic events 70 1.89e-01 0.090900 3.50e-01
AURKA Activation by TPX2 72 1.83e-01 0.090900 3.43e-01
Cardiac conduction 88 1.44e-01 0.090100 2.92e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 107 1.07e-01 0.090100 2.42e-01
DNA Replication 128 7.85e-02 0.090000 1.93e-01
S Phase 150 5.71e-02 0.090000 1.56e-01
Assembly of active LPL and LIPC lipase complexes 10 6.22e-01 0.090000 7.59e-01
Transcriptional activation of mitochondrial biogenesis 52 2.63e-01 0.089800 4.38e-01
TNFR1-induced proapoptotic signaling 24 4.48e-01 -0.089400 6.21e-01
mRNA Splicing 211 2.58e-02 0.089000 8.83e-02
Infectious disease 951 3.44e-06 0.088900 8.06e-05
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.10e-01 -0.088800 7.52e-01
DAG and IP3 signaling 33 3.78e-01 0.088800 5.54e-01
Tryptophan catabolism 12 5.95e-01 0.088700 7.41e-01
PERK regulates gene expression 30 4.01e-01 0.088700 5.79e-01
Transmission across Chemical Synapses 179 4.08e-02 0.088600 1.23e-01
Nuclear Receptor transcription pathway 38 3.45e-01 0.088600 5.18e-01
Metabolism of amine-derived hormones 10 6.29e-01 -0.088100 7.65e-01
Activation of Matrix Metalloproteinases 20 4.96e-01 0.087900 6.62e-01
Mitophagy 38 3.52e-01 0.087200 5.26e-01
Phase 2 - plateau phase 12 6.02e-01 -0.087000 7.46e-01
Association of TriC/CCT with target proteins during biosynthesis 35 3.74e-01 0.086800 5.50e-01
Diseases of programmed cell death 58 2.54e-01 0.086700 4.29e-01
tRNA processing 128 9.06e-02 -0.086600 2.14e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 4.54e-01 0.086600 6.25e-01
2-LTR circle formation 7 6.92e-01 0.086500 8.21e-01
Phase II - Conjugation of compounds 68 2.18e-01 0.086400 3.90e-01
Bile acid and bile salt metabolism 28 4.30e-01 0.086200 6.06e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 4.57e-01 0.086000 6.26e-01
Defective B3GAT3 causes JDSSDHD 10 6.38e-01 -0.085900 7.73e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.35e-02 0.085900 5.41e-02
Plasma lipoprotein assembly, remodeling, and clearance 56 2.67e-01 0.085800 4.43e-01
G alpha (12/13) signalling events 68 2.21e-01 0.085800 3.94e-01
Disease 1606 1.03e-08 0.085800 7.08e-07
Phenylalanine and tyrosine metabolism 9 6.57e-01 -0.085600 7.90e-01
Leishmania infection 210 3.30e-02 0.085400 1.04e-01
Parasitic Infection Pathways 210 3.30e-02 0.085400 1.04e-01
Interleukin-2 family signaling 38 3.65e-01 0.085000 5.39e-01
Processive synthesis on the C-strand of the telomere 19 5.22e-01 -0.084800 6.81e-01
SUMOylation of transcription cofactors 44 3.31e-01 0.084800 5.06e-01
Phosphorylation of the APC/C 20 5.13e-01 0.084600 6.73e-01
GPCR downstream signalling 396 3.92e-03 0.084500 2.01e-02
Phase 4 - resting membrane potential 9 6.61e-01 0.084400 7.94e-01
Costimulation by the CD28 family 74 2.12e-01 -0.083900 3.82e-01
Sphingolipid catabolism 11 6.31e-01 0.083700 7.66e-01
Metabolism of amino acids and derivatives 304 1.24e-02 -0.083400 5.07e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 4.54e-01 0.083200 6.25e-01
Death Receptor Signaling 145 8.40e-02 0.083100 2.02e-01
Cell recruitment (pro-inflammatory response) 25 4.74e-01 0.082800 6.42e-01
Purinergic signaling in leishmaniasis infection 25 4.74e-01 0.082800 6.42e-01
Chondroitin sulfate/dermatan sulfate metabolism 37 3.84e-01 -0.082700 5.61e-01
Metabolism of fat-soluble vitamins 26 4.66e-01 0.082600 6.36e-01
Collagen chain trimerization 26 4.66e-01 0.082600 6.36e-01
RNA Polymerase III Abortive And Retractive Initiation 40 3.67e-01 -0.082500 5.41e-01
RNA Polymerase III Transcription 40 3.67e-01 -0.082500 5.41e-01
Cytochrome c-mediated apoptotic response 13 6.09e-01 0.081900 7.52e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 7.51e-01 -0.081800 8.61e-01
Maturation of spike protein 9683686 5 7.52e-01 -0.081600 8.61e-01
Antiviral mechanism by IFN-stimulated genes 140 9.62e-02 0.081400 2.23e-01
MECP2 regulates transcription factors 5 7.53e-01 0.081400 8.62e-01
Glycosaminoglycan metabolism 95 1.70e-01 0.081400 3.26e-01
GPCR ligand binding 241 3.08e-02 0.080800 9.91e-02
Synthesis of Dolichyl-phosphate 6 7.32e-01 0.080600 8.52e-01
Transport of RCbl within the body 8 6.94e-01 -0.080300 8.22e-01
Repression of WNT target genes 14 6.04e-01 0.080100 7.47e-01
Assembly and cell surface presentation of NMDA receptors 30 4.48e-01 0.080000 6.21e-01
Potassium Channels 62 2.80e-01 0.079400 4.53e-01
Post NMDA receptor activation events 60 2.89e-01 0.079100 4.63e-01
Phosphate bond hydrolysis by NTPDase proteins 6 7.38e-01 -0.079000 8.55e-01
Nuclear Envelope Breakdown 53 3.20e-01 0.079000 4.94e-01
Signaling by GPCR 441 4.46e-03 0.079000 2.22e-02
Sensory Perception 188 6.34e-02 0.078500 1.68e-01
FGFR1c ligand binding and activation 8 7.01e-01 -0.078300 8.29e-01
Regulation of expression of SLITs and ROBOs 149 1.02e-01 -0.077700 2.32e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.15e-01 0.077600 7.54e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.15e-01 0.077600 7.54e-01
The activation of arylsulfatases 10 6.71e-01 -0.077500 8.02e-01
EPH-ephrin mediated repulsion of cells 42 3.86e-01 0.077300 5.63e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 4.29e-01 0.077200 6.06e-01
Collagen formation 63 2.90e-01 0.077100 4.63e-01
TICAM1-dependent activation of IRF3/IRF7 13 6.30e-01 -0.077100 7.66e-01
Signaling by NOTCH2 33 4.44e-01 0.077000 6.18e-01
Glycerophospholipid biosynthesis 104 1.76e-01 0.076900 3.33e-01
Prostanoid ligand receptors 8 7.07e-01 0.076800 8.33e-01
Neuronal System 262 3.28e-02 0.076600 1.04e-01
HIV Life Cycle 144 1.13e-01 0.076500 2.50e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.71e-01 0.076000 6.41e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 7.28e-01 0.076000 8.48e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 2.64e-01 -0.075600 4.39e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 7.50e-01 -0.075000 8.61e-01
Signaling by MST1 5 7.72e-01 -0.074900 8.71e-01
Polo-like kinase mediated events 16 6.05e-01 0.074600 7.48e-01
G1/S-Specific Transcription 29 4.87e-01 0.074600 6.54e-01
Diseases of glycosylation 104 1.91e-01 -0.074100 3.54e-01
Cation-coupled Chloride cotransporters 6 7.55e-01 0.073700 8.62e-01
Epigenetic regulation of gene expression 263 4.00e-02 0.073600 1.20e-01
HDR through Single Strand Annealing (SSA) 37 4.39e-01 0.073500 6.15e-01
Suppression of apoptosis 7 7.37e-01 -0.073300 8.55e-01
Cleavage of the damaged purine 21 5.62e-01 0.073100 7.17e-01
Depurination 21 5.62e-01 0.073100 7.17e-01
Recognition and association of DNA glycosylase with site containing an affected purine 21 5.62e-01 0.073100 7.17e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 3.20e-01 -0.073100 4.94e-01
Glycogen storage diseases 13 6.48e-01 0.073100 7.84e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 2.75e-01 -0.072400 4.49e-01
Interleukin-9 signaling 8 7.23e-01 0.072200 8.45e-01
Regulation of TP53 Activity through Acetylation 29 5.03e-01 -0.071800 6.68e-01
Adaptive Immune System 765 7.37e-04 0.071800 5.08e-03
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 7.25e-01 0.071700 8.47e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 6.10e-01 -0.071400 7.52e-01
SUMOylation of DNA methylation proteins 16 6.21e-01 -0.071300 7.59e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 7.28e-01 0.070900 8.48e-01
Retrograde transport at the Trans-Golgi-Network 49 3.90e-01 0.070900 5.67e-01
SUMO E3 ligases SUMOylate target proteins 161 1.21e-01 0.070800 2.62e-01
Activation of RAS in B cells 5 7.84e-01 0.070700 8.79e-01
Lysosome Vesicle Biogenesis 32 4.91e-01 0.070400 6.57e-01
Metabolism of proteins 1761 1.04e-06 0.070100 3.28e-05
Adherens junctions interactions 37 4.61e-01 0.070000 6.31e-01
SARS-CoV-1 activates/modulates innate immune responses 40 4.45e-01 0.069800 6.19e-01
Neddylation 215 7.88e-02 0.069600 1.93e-01
TNFR2 non-canonical NF-kB pathway 84 2.73e-01 0.069300 4.47e-01
Diseases associated with N-glycosylation of proteins 20 5.92e-01 -0.069200 7.41e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.55e-01 -0.068900 7.90e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 5.69e-01 -0.068600 7.23e-01
Signaling by the B Cell Receptor (BCR) 150 1.47e-01 0.068500 2.96e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 7.72e-01 -0.068300 8.71e-01
tRNA Aminoacylation 42 4.44e-01 -0.068200 6.19e-01
NS1 Mediated Effects on Host Pathways 40 4.56e-01 -0.068200 6.25e-01
Assembly of collagen fibrils and other multimeric structures 41 4.53e-01 0.067800 6.25e-01
Dual incision in TC-NER 63 3.54e-01 -0.067500 5.27e-01
Regulation of MECP2 expression and activity 28 5.37e-01 0.067400 6.96e-01
SARS-CoV-2 Infection 263 5.98e-02 0.067400 1.61e-01
Methylation 13 6.74e-01 -0.067400 8.04e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 7.75e-01 0.067400 8.72e-01
TGFBR1 KD Mutants in Cancer 6 7.75e-01 0.067400 8.72e-01
Phosphate bond hydrolysis by NUDT proteins 7 7.58e-01 -0.067300 8.64e-01
Diseases of mitotic cell cycle 38 4.73e-01 0.067300 6.42e-01
SUMOylation 167 1.34e-01 0.067300 2.78e-01
Glycosphingolipid metabolism 47 4.30e-01 0.066600 6.06e-01
Eicosanoid ligand-binding receptors 13 6.79e-01 -0.066300 8.09e-01
Other interleukin signaling 18 6.27e-01 -0.066200 7.65e-01
Recruitment of NuMA to mitotic centrosomes 88 2.85e-01 0.065900 4.58e-01
Azathioprine ADME 20 6.12e-01 0.065600 7.52e-01
Pyrimidine salvage 10 7.20e-01 0.065500 8.43e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 5.81e-01 0.065100 7.34e-01
Neurexins and neuroligins 35 5.06e-01 -0.065000 6.70e-01
Chondroitin sulfate biosynthesis 12 6.99e-01 0.064400 8.27e-01
Ca2+ activated K+ channels 6 7.85e-01 -0.064300 8.79e-01
Neurotoxicity of clostridium toxins 9 7.39e-01 -0.064000 8.56e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 5.09e-01 0.063600 6.73e-01
Mucopolysaccharidoses 11 7.15e-01 -0.063500 8.40e-01
Metabolism of carbohydrates 236 9.84e-02 0.062500 2.27e-01
mRNA Splicing - Minor Pathway 50 4.46e-01 -0.062300 6.19e-01
Transcriptional regulation by small RNAs 61 4.01e-01 0.062200 5.79e-01
Biological oxidations 135 2.15e-01 0.061800 3.86e-01
Germ layer formation at gastrulation 9 7.48e-01 0.061800 8.60e-01
Cell death signalling via NRAGE, NRIF and NADE 69 3.76e-01 0.061600 5.52e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 7.50e-01 -0.061400 8.61e-01
TRAF6 mediated NF-kB activation 23 6.12e-01 0.061200 7.52e-01
Plasma lipoprotein remodeling 18 6.54e-01 0.061100 7.89e-01
Phospholipase C-mediated cascade; FGFR2 8 7.66e-01 -0.060900 8.69e-01
Synthesis of DNA 108 2.74e-01 0.060900 4.48e-01
Regulation of CDH11 function 9 7.52e-01 0.060800 8.61e-01
eNOS activation 10 7.39e-01 0.060800 8.56e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.52e-01 -0.060800 7.11e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 5.06e-01 0.060100 6.70e-01
Diseases of DNA Double-Strand Break Repair 41 5.06e-01 0.060100 6.70e-01
Protein hydroxylation 17 6.70e-01 -0.059700 8.02e-01
Base-Excision Repair, AP Site Formation 28 5.85e-01 -0.059700 7.35e-01
Recognition of DNA damage by PCNA-containing replication complex 30 5.73e-01 -0.059400 7.26e-01
Signaling by FGFR2 IIIa TM 18 6.65e-01 0.058900 7.98e-01
Reversal of alkylation damage by DNA dioxygenases 7 7.88e-01 0.058600 8.79e-01
PIWI-interacting RNA (piRNA) biogenesis 23 6.28e-01 -0.058300 7.65e-01
NGF-stimulated transcription 32 5.71e-01 0.057900 7.24e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 7.08e-01 0.057800 8.34e-01
Transport of vitamins, nucleosides, and related molecules 31 5.80e-01 -0.057400 7.34e-01
Peroxisomal lipid metabolism 27 6.08e-01 -0.057000 7.51e-01
Viral Infection Pathways 770 8.38e-03 0.055900 3.74e-02
Nectin/Necl trans heterodimerization 5 8.31e-01 0.055200 9.08e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 6.70e-01 0.055000 8.02e-01
APC-Cdc20 mediated degradation of Nek2A 26 6.28e-01 0.055000 7.65e-01
Evasion by RSV of host interferon responses 20 6.71e-01 0.054800 8.02e-01
SARS-CoV-1 Infection 137 2.69e-01 0.054700 4.44e-01
Regulation of TP53 Activity 151 2.50e-01 0.054300 4.24e-01
SUMOylation of immune response proteins 12 7.45e-01 -0.054300 8.59e-01
HDR through Homologous Recombination (HRR) 68 4.39e-01 -0.054200 6.15e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 7.37e-01 -0.053700 8.55e-01
Pexophagy 10 7.69e-01 0.053700 8.71e-01
Metabolism of non-coding RNA 53 5.02e-01 -0.053300 6.67e-01
snRNP Assembly 53 5.02e-01 -0.053300 6.67e-01
Synthesis of substrates in N-glycan biosythesis 58 4.84e-01 -0.053100 6.51e-01
Negative regulators of DDX58/IFIH1 signaling 34 5.94e-01 -0.052900 7.41e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 8.09e-01 0.052800 8.93e-01
Positive epigenetic regulation of rRNA expression 60 4.80e-01 0.052800 6.47e-01
NoRC negatively regulates rRNA expression 60 4.81e-01 0.052600 6.49e-01
NF-kB is activated and signals survival 12 7.54e-01 0.052200 8.62e-01
Diseases associated with glycosylation precursor biosynthesis 15 7.26e-01 -0.052200 8.47e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 8.11e-01 -0.052100 8.93e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 9 7.88e-01 0.051700 8.79e-01
Defective EXT2 causes exostoses 2 9 7.88e-01 0.051700 8.79e-01
ISG15 antiviral mechanism 72 4.49e-01 0.051600 6.21e-01
NRAGE signals death through JNK 52 5.20e-01 0.051500 6.80e-01
Diseases associated with surfactant metabolism 5 8.43e-01 -0.051200 9.15e-01
Regulation of TP53 Expression and Degradation 36 5.95e-01 0.051200 7.41e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 8.03e-01 0.051000 8.91e-01
Phase 3 - rapid repolarisation 7 8.15e-01 0.051000 8.94e-01
Cobalamin (Cbl) metabolism 7 8.15e-01 0.051000 8.94e-01
Mitochondrial unfolded protein response (UPRmt) 17 7.18e-01 -0.050600 8.42e-01
Assembly Of The HIV Virion 15 7.37e-01 0.050200 8.55e-01
SARS-CoV-1-host interactions 94 4.02e-01 -0.050100 5.80e-01
Recycling of eIF2:GDP 8 8.07e-01 0.049800 8.93e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 6.88e-01 -0.049400 8.18e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 6.95e-01 0.049400 8.23e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 6.95e-01 0.049400 8.23e-01
Metabolism of water-soluble vitamins and cofactors 114 3.64e-01 -0.049300 5.38e-01
CDC6 association with the ORC:origin complex 8 8.10e-01 0.049100 8.93e-01
Processing of SMDT1 15 7.42e-01 -0.049100 8.57e-01
Synthesis of bile acids and bile salts 25 6.71e-01 0.049000 8.02e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 7.38e-01 0.048300 8.55e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 7.06e-01 0.047600 8.33e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 6.03e-01 0.047600 7.46e-01
TP53 Regulates Transcription of Cell Death Genes 42 5.94e-01 0.047500 7.41e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 7.14e-01 -0.047400 8.40e-01
ERBB2 Activates PTK6 Signaling 8 8.17e-01 0.047300 8.94e-01
O-linked glycosylation 81 4.65e-01 0.047000 6.35e-01
Antimicrobial peptides 33 6.44e-01 0.046500 7.80e-01
RND2 GTPase cycle 36 6.33e-01 0.046000 7.68e-01
Collagen biosynthesis and modifying enzymes 45 5.93e-01 0.046000 7.41e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 8.34e-01 -0.045700 9.10e-01
RNA Polymerase II Transcription 1185 8.13e-03 0.045700 3.66e-02
Regulation of PTEN gene transcription 59 5.47e-01 0.045400 7.06e-01
Synthesis of pyrophosphates in the cytosol 8 8.24e-01 -0.045300 9.02e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 7.08e-01 0.045100 8.34e-01
Caspase activation via Death Receptors in the presence of ligand 16 7.55e-01 -0.045100 8.62e-01
Anchoring of the basal body to the plasma membrane 97 4.48e-01 0.044600 6.21e-01
Formation of Incision Complex in GG-NER 43 6.13e-01 0.044500 7.53e-01
Fertilization 12 7.93e-01 0.043800 8.82e-01
HDL assembly 6 8.53e-01 -0.043800 9.21e-01
Negative epigenetic regulation of rRNA expression 63 5.49e-01 0.043700 7.08e-01
Viral Messenger RNA Synthesis 44 6.17e-01 -0.043600 7.56e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 7.49e-01 -0.043500 8.61e-01
MicroRNA (miRNA) biogenesis 24 7.13e-01 -0.043400 8.39e-01
Synthesis of 5-eicosatetraenoic acids 7 8.43e-01 0.043300 9.15e-01
CDH11 homotypic and heterotypic interactions 5 8.67e-01 -0.043300 9.34e-01
Beta-oxidation of very long chain fatty acids 11 8.04e-01 -0.043200 8.92e-01
Cytosolic tRNA aminoacylation 24 7.15e-01 0.043100 8.40e-01
Cytosolic sulfonation of small molecules 18 7.54e-01 0.042700 8.62e-01
Ephrin signaling 17 7.62e-01 0.042300 8.67e-01
Interactions of Rev with host cellular proteins 37 6.56e-01 -0.042300 7.90e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 7.64e-01 0.042100 8.67e-01
Acyl chain remodelling of PS 14 7.86e-01 0.042000 8.79e-01
SUMOylation of ubiquitinylation proteins 39 6.53e-01 -0.041600 7.89e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 8.11e-01 -0.041600 8.93e-01
Gene expression (Transcription) 1391 9.55e-03 0.041500 4.16e-02
FGFR2 alternative splicing 25 7.20e-01 0.041300 8.43e-01
mRNA 3’-end processing 57 5.90e-01 0.041300 7.40e-01
IRF3-mediated induction of type I IFN 12 8.05e-01 0.041100 8.92e-01
Voltage gated Potassium channels 26 7.18e-01 0.041000 8.42e-01
Adenylate cyclase activating pathway 8 8.41e-01 -0.040900 9.15e-01
Drug ADME 55 6.01e-01 0.040800 7.46e-01
Potential therapeutics for SARS 148 3.93e-01 -0.040700 5.70e-01
Diseases of metabolism 198 3.26e-01 -0.040500 5.00e-01
Organelle biogenesis and maintenance 278 2.47e-01 0.040400 4.21e-01
RNA Polymerase I Promoter Escape 45 6.43e-01 0.040000 7.78e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 4.06e-01 0.039700 5.84e-01
Nuclear import of Rev protein 34 6.90e-01 -0.039600 8.19e-01
AKT phosphorylates targets in the cytosol 14 7.98e-01 0.039400 8.87e-01
Translesion synthesis by POLK 17 7.79e-01 -0.039300 8.74e-01
Transport of nucleotide sugars 9 8.38e-01 0.039300 9.14e-01
Basigin interactions 21 7.56e-01 0.039200 8.62e-01
Formation of WDR5-containing histone-modifying complexes 42 6.61e-01 -0.039100 7.94e-01
Signaling by TGFBR3 39 6.72e-01 0.039100 8.03e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 78 5.55e-01 -0.038600 7.14e-01
TNF signaling 56 6.19e-01 0.038400 7.58e-01
Diseases of hemostasis 13 8.12e-01 0.038000 8.93e-01
FGFR4 ligand binding and activation 5 8.83e-01 -0.037900 9.42e-01
SUMOylation of transcription factors 16 7.93e-01 -0.037800 8.82e-01
Transport of Mature Transcript to Cytoplasm 81 5.57e-01 0.037800 7.14e-01
Centrosome maturation 81 5.61e-01 0.037300 7.17e-01
Recruitment of mitotic centrosome proteins and complexes 81 5.61e-01 0.037300 7.17e-01
Aspartate and asparagine metabolism 8 8.57e-01 -0.036700 9.24e-01
Serotonin Neurotransmitter Release Cycle 15 8.06e-01 -0.036600 8.92e-01
Fibronectin matrix formation 6 8.77e-01 -0.036600 9.39e-01
Nucleotide Excision Repair 108 5.13e-01 -0.036500 6.73e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 7.43e-01 0.036400 8.57e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 7.43e-01 0.036400 8.57e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 5.64e-01 -0.036400 7.18e-01
Synthesis, secretion, and deacylation of Ghrelin 11 8.35e-01 0.036300 9.11e-01
Carboxyterminal post-translational modifications of tubulin 33 7.20e-01 0.036000 8.43e-01
Chromosome Maintenance 102 5.31e-01 -0.035900 6.89e-01
Urea cycle 6 8.80e-01 -0.035500 9.41e-01
Transcription of E2F targets under negative control by DREAM complex 19 7.90e-01 0.035300 8.80e-01
Loss of Function of SMAD2/3 in Cancer 7 8.72e-01 0.035200 9.37e-01
Xenobiotics 9 8.56e-01 0.035000 9.23e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 7.72e-01 0.034900 8.71e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 7.72e-01 0.034900 8.71e-01
RHOBTB3 ATPase cycle 10 8.49e-01 -0.034900 9.19e-01
Generic Transcription Pathway 1067 5.45e-02 0.034900 1.52e-01
Glutamate Neurotransmitter Release Cycle 20 7.87e-01 -0.034800 8.79e-01
Resolution of D-Loop Structures 35 7.25e-01 0.034400 8.47e-01
Regulation of Expression and Function of Type II Classical Cadherins 23 7.78e-01 0.034000 8.73e-01
Regulation of Homotypic Cell-Cell Adhesion 23 7.78e-01 0.034000 8.73e-01
p75NTR recruits signalling complexes 12 8.39e-01 0.034000 9.14e-01
Regulation of beta-cell development 21 7.92e-01 0.033200 8.82e-01
Heparan sulfate/heparin (HS-GAG) metabolism 39 7.20e-01 -0.033100 8.43e-01
Neurotransmitter release cycle 38 7.26e-01 0.032800 8.47e-01
Gene Silencing by RNA 87 5.98e-01 0.032700 7.43e-01
Activation of kainate receptors upon glutamate binding 25 7.78e-01 0.032600 8.73e-01
Myoclonic epilepsy of Lafora 8 8.73e-01 0.032500 9.37e-01
Mitochondrial protein degradation 96 5.85e-01 0.032200 7.35e-01
Downregulation of ERBB2 signaling 24 7.86e-01 -0.032000 8.79e-01
SUMOylation of DNA damage response and repair proteins 77 6.28e-01 0.031900 7.65e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 9.02e-01 0.031800 9.51e-01
Interleukin-18 signaling 6 8.93e-01 0.031700 9.48e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 7.95e-01 0.031300 8.84e-01
Metabolism 1808 2.83e-02 0.031100 9.41e-02
Cell surface interactions at the vascular wall 170 4.84e-01 -0.031100 6.51e-01
Rev-mediated nuclear export of HIV RNA 35 7.51e-01 -0.031000 8.61e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 8.41e-01 -0.030900 9.15e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.11e-01 0.030800 8.93e-01
SARS-CoV Infections 428 2.78e-01 0.030600 4.52e-01
Formation of the Early Elongation Complex 33 7.61e-01 -0.030600 8.66e-01
Formation of the HIV-1 Early Elongation Complex 33 7.61e-01 -0.030600 8.66e-01
E2F mediated regulation of DNA replication 22 8.05e-01 0.030400 8.92e-01
Biosynthesis of DHA-derived SPMs 13 8.50e-01 -0.030300 9.20e-01
RMTs methylate histone arginines 35 7.57e-01 0.030300 8.63e-01
Regulation of TP53 Degradation 35 7.58e-01 0.030100 8.64e-01
Cytosolic sensors of pathogen-associated DNA 63 6.80e-01 0.030100 8.10e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 8.76e-01 -0.030000 9.39e-01
Visual phototransduction 58 6.94e-01 0.029900 8.22e-01
Mitochondrial calcium ion transport 22 8.09e-01 -0.029800 8.93e-01
Synthesis of IP3 and IP4 in the cytosol 22 8.11e-01 -0.029500 8.93e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 7.66e-01 0.029500 8.69e-01
FGFR2 mutant receptor activation 23 8.10e-01 -0.029000 8.93e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 9.11e-01 -0.029000 9.55e-01
Nephron development 5 9.11e-01 -0.028900 9.55e-01
Inositol phosphate metabolism 42 7.48e-01 0.028700 8.60e-01
Interferon Signaling 237 4.47e-01 0.028700 6.20e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 8.04e-01 0.028600 8.92e-01
DNA Damage Bypass 47 7.41e-01 -0.027900 8.56e-01
Metabolism of vitamins and cofactors 163 5.42e-01 -0.027700 7.00e-01
mRNA Capping 29 7.97e-01 0.027600 8.86e-01
Processing and activation of SUMO 10 8.81e-01 0.027300 9.41e-01
Anti-inflammatory response favouring Leishmania parasite infection 131 5.91e-01 -0.027200 7.40e-01
Leishmania parasite growth and survival 131 5.91e-01 -0.027200 7.40e-01
Protein lipoylation 10 8.82e-01 0.027200 9.41e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 7.15e-01 -0.027000 8.40e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 9.03e-01 0.026500 9.51e-01
CTLA4 inhibitory signaling 21 8.33e-01 0.026500 9.10e-01
FLT3 signaling by CBL mutants 7 9.04e-01 -0.026400 9.51e-01
Acyl chain remodelling of PE 19 8.43e-01 0.026300 9.15e-01
Interconversion of nucleotide di- and triphosphates 27 8.13e-01 -0.026200 8.93e-01
Sensory processing of sound by outer hair cells of the cochlea 40 7.76e-01 -0.026000 8.73e-01
Class B/2 (Secretin family receptors) 54 7.47e-01 0.025400 8.60e-01
Activation of BH3-only proteins 29 8.13e-01 -0.025300 8.93e-01
Metabolism of cofactors 25 8.28e-01 -0.025100 9.06e-01
Regulation of endogenous retroelements 92 6.80e-01 0.024900 8.10e-01
NCAM signaling for neurite out-growth 47 7.69e-01 0.024800 8.71e-01
Processing of Intronless Pre-mRNAs 20 8.48e-01 0.024800 9.19e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 7.31e-01 0.024500 8.50e-01
Metabolism of nucleotides 86 7.02e-01 -0.023800 8.30e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 8.17e-01 -0.023700 8.94e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 8.17e-01 -0.023700 8.94e-01
RNA Polymerase II Transcription Termination 66 7.40e-01 0.023600 8.56e-01
Formation of TC-NER Pre-Incision Complex 51 7.73e-01 0.023400 8.71e-01
Cargo trafficking to the periciliary membrane 48 7.79e-01 0.023400 8.74e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 9.15e-01 0.023300 9.57e-01
Interleukin-23 signaling 7 9.16e-01 -0.023100 9.57e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 7.63e-01 -0.023100 8.67e-01
Defective GALNT12 causes CRCS1 8 9.11e-01 -0.022800 9.55e-01
TRAF6 mediated IRF7 activation 15 8.79e-01 0.022700 9.40e-01
SLC-mediated transmembrane transport 171 6.11e-01 0.022600 7.52e-01
Activation of SMO 14 8.84e-01 -0.022500 9.42e-01
FCERI mediated NF-kB activation 129 6.66e-01 0.022000 7.98e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 7.47e-01 0.022000 8.60e-01
Regulation of actin dynamics for phagocytic cup formation 123 6.76e-01 0.021800 8.06e-01
Activation of C3 and C5 7 9.21e-01 -0.021700 9.61e-01
Dermatan sulfate biosynthesis 6 9.27e-01 0.021500 9.62e-01
Respiratory electron transport 149 6.55e-01 -0.021200 7.90e-01
RNA Polymerase I Promoter Clearance 64 7.70e-01 -0.021100 8.71e-01
RNA Polymerase I Transcription 64 7.70e-01 -0.021100 8.71e-01
Homologous DNA Pairing and Strand Exchange 43 8.11e-01 0.021100 8.93e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.84e-01 0.021000 9.42e-01
Regulation of signaling by NODAL 6 9.29e-01 -0.021000 9.63e-01
Cell-cell junction organization 56 7.86e-01 -0.021000 8.79e-01
Triglyceride biosynthesis 9 9.13e-01 0.021000 9.56e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 8.14e-01 0.020600 8.93e-01
STING mediated induction of host immune responses 15 8.91e-01 0.020400 9.48e-01
TRP channels 21 8.72e-01 0.020300 9.37e-01
RSV-host interactions 76 7.62e-01 0.020100 8.67e-01
HDR through MMEJ (alt-NHEJ) 12 9.05e-01 0.020000 9.51e-01
FGFRL1 modulation of FGFR1 signaling 7 9.28e-01 -0.019700 9.63e-01
SUMOylation of SUMOylation proteins 35 8.41e-01 -0.019600 9.15e-01
Diseases associated with glycosaminoglycan metabolism 24 8.70e-01 0.019300 9.37e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 9.25e-01 -0.019100 9.62e-01
Cell junction organization 77 7.73e-01 0.019000 8.71e-01
Deactivation of the beta-catenin transactivating complex 36 8.44e-01 0.019000 9.16e-01
P2Y receptors 10 9.18e-01 -0.018800 9.58e-01
Phospholipase C-mediated cascade; FGFR3 5 9.42e-01 0.018800 9.70e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 8.74e-01 -0.018300 9.37e-01
Phase 0 - rapid depolarisation 23 8.79e-01 -0.018300 9.40e-01
Interferon gamma signaling 87 7.69e-01 -0.018200 8.71e-01
Signaling by Activin 13 9.10e-01 -0.018200 9.55e-01
Defects of platelet adhesion to exposed collagen 6 9.40e-01 0.017900 9.69e-01
Integration of provirus 9 9.26e-01 0.017800 9.62e-01
TGFBR3 expression 20 8.93e-01 -0.017400 9.48e-01
Purine catabolism 16 9.04e-01 -0.017400 9.51e-01
Metabolism of porphyrins 22 8.90e-01 -0.017000 9.48e-01
Transcriptional Regulation by VENTX 38 8.57e-01 -0.016900 9.24e-01
Vitamin B5 (pantothenate) metabolism 20 8.96e-01 -0.016800 9.50e-01
Dopamine Neurotransmitter Release Cycle 20 8.97e-01 0.016700 9.50e-01
Regulation of TNFR1 signaling 47 8.46e-01 0.016400 9.17e-01
HIV elongation arrest and recovery 32 8.74e-01 0.016300 9.37e-01
Pausing and recovery of HIV elongation 32 8.74e-01 0.016300 9.37e-01
Vitamin B2 (riboflavin) metabolism 6 9.45e-01 -0.016200 9.73e-01
Aerobic respiration and respiratory electron transport 245 6.64e-01 0.016100 7.97e-01
Glyoxylate metabolism and glycine degradation 13 9.22e-01 -0.015600 9.61e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 7.87e-01 0.015300 8.79e-01
Norepinephrine Neurotransmitter Release Cycle 14 9.21e-01 -0.015300 9.61e-01
LTC4-CYSLTR mediated IL4 production 5 9.53e-01 0.015200 9.77e-01
DNA Repair 288 6.60e-01 -0.015100 7.93e-01
Aflatoxin activation and detoxification 14 9.24e-01 -0.014800 9.62e-01
Paracetamol ADME 19 9.12e-01 0.014600 9.55e-01
SUMOylation of chromatin organization proteins 57 8.49e-01 -0.014600 9.19e-01
Release of apoptotic factors from the mitochondria 6 9.51e-01 -0.014500 9.76e-01
Signaling by ROBO receptors 189 7.36e-01 -0.014200 8.55e-01
Activated point mutants of FGFR2 7 9.49e-01 0.014100 9.75e-01
Peroxisomal protein import 58 8.53e-01 -0.014100 9.21e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.46e-01 -0.013900 9.73e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 8.92e-01 -0.013900 9.48e-01
Glucagon-type ligand receptors 19 9.17e-01 0.013800 9.58e-01
Cleavage of the damaged pyrimidine 26 9.04e-01 -0.013700 9.51e-01
Depyrimidination 26 9.04e-01 -0.013700 9.51e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 9.04e-01 -0.013700 9.51e-01
Complex IV assembly 45 8.75e-01 0.013500 9.38e-01
The phototransduction cascade 26 9.05e-01 0.013500 9.51e-01
SLC transporter disorders 75 8.51e-01 0.012500 9.20e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 9.33e-01 -0.012500 9.64e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 8.92e-01 0.012000 9.48e-01
Deposition of new CENPA-containing nucleosomes at the centromere 37 9.01e-01 0.011800 9.51e-01
Nucleosome assembly 37 9.01e-01 0.011800 9.51e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 9.31e-01 0.011800 9.64e-01
Sensory processing of sound 57 8.86e-01 0.011000 9.43e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 9.60e-01 0.010900 9.81e-01
RUNX2 regulates bone development 21 9.32e-01 -0.010800 9.64e-01
Telomere Maintenance 78 8.70e-01 -0.010700 9.37e-01
Formation of apoptosome 11 9.51e-01 0.010700 9.76e-01
Regulation of the apoptosome activity 11 9.51e-01 0.010700 9.76e-01
DNA Damage Reversal 8 9.59e-01 -0.010500 9.81e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 9.08e-01 0.010300 9.53e-01
Processing of Capped Intronless Pre-mRNA 29 9.24e-01 -0.010200 9.62e-01
Nuclear Pore Complex (NPC) Disassembly 36 9.17e-01 0.010000 9.58e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.26e-01 -0.009730 9.62e-01
Tat-mediated HIV elongation arrest and recovery 30 9.26e-01 -0.009730 9.62e-01
TP53 Regulates Transcription of DNA Repair Genes 61 8.95e-01 -0.009730 9.50e-01
Metabolism of nitric oxide: NOS3 activation and regulation 13 9.52e-01 -0.009710 9.76e-01
Complex I biogenesis 66 8.97e-01 0.009220 9.50e-01
RUNX3 Regulates Immune Response and Cell Migration 5 9.73e-01 0.008750 9.90e-01
Signaling by activated point mutants of FGFR1 5 9.73e-01 -0.008720 9.90e-01
Homology Directed Repair 110 8.79e-01 -0.008400 9.40e-01
Glycosphingolipid catabolism 31 9.36e-01 0.008300 9.66e-01
Export of Viral Ribonucleoproteins from Nucleus 33 9.36e-01 -0.008100 9.66e-01
Cilium Assembly 187 8.51e-01 0.007960 9.20e-01
Synthesis of PA 31 9.41e-01 0.007620 9.70e-01
WNT mediated activation of DVL 8 9.70e-01 0.007600 9.88e-01
Sensory processing of sound by inner hair cells of the cochlea 54 9.27e-01 0.007240 9.62e-01
Intraflagellar transport 47 9.33e-01 -0.007040 9.64e-01
Biosynthesis of maresins 5 9.79e-01 0.006680 9.91e-01
Formation of the Editosome 6 9.78e-01 -0.006460 9.91e-01
mRNA Editing: C to U Conversion 6 9.78e-01 -0.006460 9.91e-01
Lysine catabolism 10 9.72e-01 0.006440 9.89e-01
FCGR3A-mediated phagocytosis 121 9.03e-01 0.006410 9.51e-01
Leishmania phagocytosis 121 9.03e-01 0.006410 9.51e-01
Parasite infection 121 9.03e-01 0.006410 9.51e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 9.67e-01 -0.006100 9.86e-01
Postmitotic nuclear pore complex (NPC) reformation 27 9.62e-01 0.005310 9.82e-01
Transcriptional Regulation by E2F6 34 9.60e-01 -0.004930 9.81e-01
Membrane binding and targetting of GAG proteins 13 9.76e-01 -0.004870 9.91e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 9.76e-01 -0.004870 9.91e-01
Vitamin D (calciferol) metabolism 10 9.80e-01 0.004680 9.91e-01
SUMOylation of DNA replication proteins 46 9.56e-01 -0.004670 9.79e-01
Diseases of DNA repair 50 9.55e-01 0.004630 9.78e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 9.81e-01 -0.004410 9.91e-01
DNA Double-Strand Break Repair 137 9.31e-01 0.004260 9.64e-01
Metabolism of folate and pterines 16 9.77e-01 -0.004150 9.91e-01
Reactions specific to the complex N-glycan synthesis pathway 7 9.85e-01 0.004100 9.93e-01
TNFR1-induced NF-kappa-B signaling pathway 32 9.69e-01 0.004030 9.87e-01
Protein-protein interactions at synapses 54 9.61e-01 0.003890 9.81e-01
CaMK IV-mediated phosphorylation of CREB 8 9.85e-01 0.003860 9.93e-01
DNA Damage Recognition in GG-NER 38 9.67e-01 -0.003850 9.86e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 9.82e-01 0.003800 9.92e-01
SARS-CoV-2-host interactions 181 9.32e-01 0.003670 9.64e-01
Intrinsic Pathway for Apoptosis 53 9.64e-01 -0.003610 9.84e-01
Regulation of CDH11 Expression and Function 22 9.78e-01 0.003340 9.91e-01
Fatty acid metabolism 152 9.51e-01 -0.002870 9.76e-01
Signaling by MAPK mutants 6 9.92e-01 0.002420 9.96e-01
SLC15A4:TASL-dependent IRF5 activation 6 9.92e-01 0.002240 9.96e-01
CD28 co-stimulation 33 9.82e-01 -0.002220 9.92e-01
Regulation of CDH11 mRNA translation by microRNAs 8 9.91e-01 0.002210 9.96e-01
Regulation of NPAS4 mRNA translation 8 9.91e-01 0.002210 9.96e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 9.80e-01 0.002180 9.91e-01
HIV Transcription Elongation 42 9.80e-01 0.002180 9.91e-01
Tat-mediated elongation of the HIV-1 transcript 42 9.80e-01 0.002180 9.91e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 9.94e-01 -0.002000 9.97e-01
Metabolism of RNA 717 9.30e-01 -0.001910 9.64e-01
WNT ligand biogenesis and trafficking 20 9.89e-01 -0.001840 9.95e-01
Aspirin ADME 13 9.91e-01 0.001830 9.96e-01
Transport of the SLBP Dependant Mature mRNA 36 9.87e-01 0.001580 9.94e-01
SUMOylation of RNA binding proteins 47 9.87e-01 0.001380 9.94e-01
Diseases of carbohydrate metabolism 29 9.90e-01 -0.001280 9.96e-01
Mismatch Repair 15 9.95e-01 0.000917 9.97e-01
Nuclear events stimulated by ALK signaling in cancer 33 9.94e-01 0.000737 9.97e-01
Transport of the SLBP independent Mature mRNA 35 9.94e-01 -0.000681 9.97e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 9.97e-01 0.000659 9.98e-01
Apoptotic factor-mediated response 19 9.97e-01 -0.000535 9.98e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 9.99e-01 0.000146 9.99e-01


Detailed Gene set reports



MET activates PI3K/AKT signaling
set MET activates PI3K/AKT signaling
setSize 5
pANOVA 0.00139
s.dist 0.825
p.adjustANOVA 0.00878


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF 9945
PIK3R1 9177
PIK3CA 8513
GRB2 8372
GAB1 5835

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HGF 9945
PIK3R1 9177
PIK3CA 8513
GRB2 8372
GAB1 5835


CD163 mediating an anti-inflammatory response
set CD163 mediating an anti-inflammatory response
setSize 8
pANOVA 6.18e-05
s.dist 0.818
p.adjustANOVA 0.000698


Top enriched genes
Top 20 genes
GeneID Gene Rank
ADAM17 9686
CD163 9669
MAPK14 9667
PLK2 9360
FURIN 9107
IL10 8604
MYH9 6748
RHBDF2 3445

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADAM17 9686
CD163 9669
MAPK14 9667
PLK2 9360
FURIN 9107
IL10 8604
MYH9 6748
RHBDF2 3445


NFE2L2 regulates pentose phosphate pathway genes
set NFE2L2 regulates pentose phosphate pathway genes
setSize 8
pANOVA 0.00015
s.dist 0.774
p.adjustANOVA 0.00137


Top enriched genes
Top 20 genes
GeneID Gene Rank
PGD 10141
TKT 8627
G6PD 7825
CREBBP 7663
EP300 7331
TALDO1 7288
MAFG 7128
NFE2L2 6552

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PGD 10141
TKT 8627
G6PD 7825
CREBBP 7663
EP300 7331
TALDO1 7288
MAFG 7128
NFE2L2 6552


Cohesin Loading onto Chromatin
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 3.09e-05
s.dist 0.761
p.adjustANOVA 0.00042


Top enriched genes
Top 20 genes
GeneID Gene Rank
NIPBL 9494
RAD21 9429
PDS5A 9380
STAG2 9130
STAG1 9104
PDS5B 8887
WAPL 8590
SMC3 7527
SMC1A 7032
MAU2 -1773

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NIPBL 9494
RAD21 9429
PDS5A 9380
STAG2 9130
STAG1 9104
PDS5B 8887
WAPL 8590
SMC3 7527
SMC1A 7032
MAU2 -1773


Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
set Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
setSize 6
pANOVA 0.00229
s.dist 0.719
p.adjustANOVA 0.0132


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD44 9911
IGF2BP2 8905
IGF2BP3 8503
ACTB 6684
H19 6596
MYC 2822

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD44 9911
IGF2BP2 8905
IGF2BP3 8503
ACTB 6684
H19 6596
MYC 2822


Establishment of Sister Chromatid Cohesion
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 9.33e-05
s.dist 0.68
p.adjustANOVA 0.000944


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD21 9429
PDS5A 9380
STAG2 9130
STAG1 9104
PDS5B 8887
WAPL 8590
SMC3 7527
SMC1A 7032
ESCO1 4121
ESCO2 4111
CDCA5 -2245

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD21 9429
PDS5A 9380
STAG2 9130
STAG1 9104
PDS5B 8887
WAPL 8590
SMC3 7527
SMC1A 7032
ESCO1 4121
ESCO2 4111
CDCA5 -2245


Scavenging by Class A Receptors
set Scavenging by Class A Receptors
setSize 10
pANOVA 0.000315
s.dist 0.658
p.adjustANOVA 0.00256


Top enriched genes
Top 20 genes
GeneID Gene Rank
CALR 9987
HSP90B1 9964
MARCO 9708
COLEC12 8260
MSR1 7725
FTL 7628
APOE 5185
COL4A2 4868
FTH1 2574
SCGB3A2 -39

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CALR 9987
HSP90B1 9964
MARCO 9708
COLEC12 8260
MSR1 7725
FTL 7628
APOE 5185
COL4A2 4868
FTH1 2574
SCGB3A2 -39


MET activates RAP1 and RAC1
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.000316
s.dist 0.658
p.adjustANOVA 0.00256


Top enriched genes
Top 20 genes
GeneID Gene Rank
HGF 9945
RAP1B 9931
RAP1A 8935
GRB2 8372
DOCK7 8003
RAC1 7718
GAB1 5835
CRK 3941
CRKL 1753
RAPGEF1 1408

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HGF 9945
RAP1B 9931
RAP1A 8935
GRB2 8372
DOCK7 8003
RAC1 7718
GAB1 5835
CRK 3941
CRKL 1753
RAPGEF1 1408


RUNX1 regulates transcription of genes involved in BCR signaling
set RUNX1 regulates transcription of genes involved in BCR signaling
setSize 6
pANOVA 0.00691
s.dist 0.637
p.adjustANOVA 0.0321


Top enriched genes
Top 20 genes
GeneID Gene Rank
RUNX1 10206
ELF1 9821
ELF2 9691
CBFB 6637
PAX5 1548
BLK 279

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUNX1 10206
ELF1 9821
ELF2 9691
CBFB 6637
PAX5 1548
BLK 279


ATF6 (ATF6-alpha) activates chaperone genes
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.00072
s.dist 0.618
p.adjustANOVA 0.00498


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 10016
CALR 9987
HSP90B1 9964
ATF6 9692
NFYA 7987
XBP1 5378
ATF4 4820
NFYC 4809
DDIT3 1935
NFYB -3010

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 10016
CALR 9987
HSP90B1 9964
ATF6 9692
NFYA 7987
XBP1 5378
ATF4 4820
NFYC 4809
DDIT3 1935
NFYB -3010


Gain-of-function MRAS complexes activate RAF signaling
set Gain-of-function MRAS complexes activate RAF signaling
setSize 8
pANOVA 0.00287
s.dist 0.609
p.adjustANOVA 0.0158


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB 10027
SHOC2 9851
YWHAB 8310
BRAF 5844
PPP1CC 5696
ARAF 3849
RAF1 2475
MRAS 2462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB 10027
SHOC2 9851
YWHAB 8310
BRAF 5844
PPP1CC 5696
ARAF 3849
RAF1 2475
MRAS 2462


SHOC2 M1731 mutant abolishes MRAS complex function
set SHOC2 M1731 mutant abolishes MRAS complex function
setSize 8
pANOVA 0.00287
s.dist 0.609
p.adjustANOVA 0.0158


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB 10027
SHOC2 9851
YWHAB 8310
BRAF 5844
PPP1CC 5696
ARAF 3849
RAF1 2475
MRAS 2462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB 10027
SHOC2 9851
YWHAB 8310
BRAF 5844
PPP1CC 5696
ARAF 3849
RAF1 2475
MRAS 2462


Signaling by MRAS-complex mutants
set Signaling by MRAS-complex mutants
setSize 8
pANOVA 0.00287
s.dist 0.609
p.adjustANOVA 0.0158


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB 10027
SHOC2 9851
YWHAB 8310
BRAF 5844
PPP1CC 5696
ARAF 3849
RAF1 2475
MRAS 2462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB 10027
SHOC2 9851
YWHAB 8310
BRAF 5844
PPP1CC 5696
ARAF 3849
RAF1 2475
MRAS 2462


APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
set APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
setSize 7
pANOVA 0.00538
s.dist -0.607
p.adjustANOVA 0.026


Top enriched genes
Top 20 genes
GeneID Gene Rank
PNKP -10609
OGG1 -10517
NEIL1 -10376
NEIL2 -8856
XRCC1 -5795
LIG3 -3035
POLB 1212

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PNKP -10609
OGG1 -10517
NEIL1 -10376
NEIL2 -8856
XRCC1 -5795
LIG3 -3035
POLB 1212


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0192
s.dist -0.605
p.adjustANOVA 0.0714


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 -10868
TSTD1 -8099
TST -7628
SUOX -7208
ETHE1 -320

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 -10868
TSTD1 -8099
TST -7628
SUOX -7208
ETHE1 -320


Relaxin receptors
set Relaxin receptors
setSize 5
pANOVA 0.0207
s.dist 0.598
p.adjustANOVA 0.0761


Top enriched genes
Top 20 genes
GeneID Gene Rank
RLN3 8038
RXFP2 7305
RXFP4 7190
RLN2 6272
INSL3 931

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RLN3 8038
RXFP2 7305
RXFP4 7190
RLN2 6272
INSL3 931


Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
set Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize 11
pANOVA 0.000633
s.dist 0.595
p.adjustANOVA 0.00446


Top enriched genes
Top 20 genes
GeneID Gene Rank
LYN 9820
PIK3CB 9583
PIK3CG 9343
PIK3R1 9177
IRS2 8653
PIK3CA 8513
GAB1 5835
JAK2 4832
PIK3R5 3309
PIK3CD 679
EPOR -4649

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LYN 9820
PIK3CB 9583
PIK3CG 9343
PIK3R1 9177
IRS2 8653
PIK3CA 8513
GAB1 5835
JAK2 4832
PIK3R5 3309
PIK3CD 679
EPOR -4649


STAT5 activation downstream of FLT3 ITD mutants
set STAT5 activation downstream of FLT3 ITD mutants
setSize 9
pANOVA 0.00201
s.dist 0.594
p.adjustANOVA 0.012


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIM1 10190
PTPN11 9106
GRB2 8372
CDKN1A 7780
GAB2 7558
FLT3 6373
STAT5B 4600
BCL2L1 1736
STAT5A -2491

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIM1 10190
PTPN11 9106
GRB2 8372
CDKN1A 7780
GAB2 7558
FLT3 6373
STAT5B 4600
BCL2L1 1736
STAT5A -2491


Cross-presentation of particulate exogenous antigens (phagosomes)
set Cross-presentation of particulate exogenous antigens (phagosomes)
setSize 8
pANOVA 0.00378
s.dist 0.591
p.adjustANOVA 0.0196


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD36 10111
ITGAV 8395
NCF4 8296
CYBB 8058
NCF2 6134
NCF1 5509
ITGB5 1686
CYBA -1155

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD36 10111
ITGAV 8395
NCF4 8296
CYBB 8058
NCF2 6134
NCF1 5509
ITGB5 1686
CYBA -1155


Erythrocytes take up oxygen and release carbon dioxide
set Erythrocytes take up oxygen and release carbon dioxide
setSize 7
pANOVA 0.00684
s.dist 0.59
p.adjustANOVA 0.0319


Top enriched genes
Top 20 genes
GeneID Gene Rank
CA4 9682
CA1 9645
HBB 8884
HBA1 5379
AQP1 4742
SLC4A1 3017
CA2 -261

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CA4 9682
CA1 9645
HBB 8884
HBA1 5379
AQP1 4742
SLC4A1 3017
CA2 -261


Wax and plasmalogen biosynthesis
set Wax and plasmalogen biosynthesis
setSize 5
pANOVA 0.0241
s.dist 0.582
p.adjustANOVA 0.0845


Top enriched genes
Top 20 genes
GeneID Gene Rank
FAR1 9845
AGPS 8398
FAR2 5069
GNPAT 4766
DHRS7B 858

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FAR1 9845
AGPS 8398
FAR2 5069
GNPAT 4766
DHRS7B 858


Eicosanoids
set Eicosanoids
setSize 6
pANOVA 0.0136
s.dist 0.582
p.adjustANOVA 0.0541


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP4F8 9677
TBXAS1 8189
CYP4F22 8079
CYP4F3 7991
CYP4F2 5934
CYP4F12 -5191

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F8 9677
TBXAS1 8189
CYP4F22 8079
CYP4F3 7991
CYP4F2 5934
CYP4F12 -5191


Regulation of gene expression by Hypoxia-inducible Factor
set Regulation of gene expression by Hypoxia-inducible Factor
setSize 8
pANOVA 0.00459
s.dist 0.579
p.adjustANOVA 0.0227


Top enriched genes
Top 20 genes
GeneID Gene Rank
HIF1A 9792
HIGD1A 9513
CREBBP 7663
EP300 7331
CITED2 6284
VEGFA 5190
ARNT 3039
HIF3A -2849

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIF1A 9792
HIGD1A 9513
CREBBP 7663
EP300 7331
CITED2 6284
VEGFA 5190
ARNT 3039
HIF3A -2849


Inhibition of Signaling by Overexpressed EGFR
set Inhibition of Signaling by Overexpressed EGFR
setSize 5
pANOVA 0.0257
s.dist 0.576
p.adjustANOVA 0.0879


Top enriched genes
Top 20 genes
GeneID Gene Rank
TGFA 9884
HBEGF 7903
EGF 6300
AREG 3129
EREG 1382

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGFA 9884
HBEGF 7903
EGF 6300
AREG 3129
EREG 1382


Signaling by Overexpressed Wild-Type EGFR in Cancer
set Signaling by Overexpressed Wild-Type EGFR in Cancer
setSize 5
pANOVA 0.0257
s.dist 0.576
p.adjustANOVA 0.0879


Top enriched genes
Top 20 genes
GeneID Gene Rank
TGFA 9884
HBEGF 7903
EGF 6300
AREG 3129
EREG 1382

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGFA 9884
HBEGF 7903
EGF 6300
AREG 3129
EREG 1382


Signaling by FLT3 ITD and TKD mutants
set Signaling by FLT3 ITD and TKD mutants
setSize 15
pANOVA 0.000139
s.dist 0.568
p.adjustANOVA 0.00129


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIM1 10190
PIK3R1 9177
PTPN11 9106
PIK3CA 8513
NRAS 8452
GRB2 8372
CDKN1A 7780
KRAS 7742
GAB2 7558
FLT3 6373
SOS1 6051
STAT5B 4600
BCL2L1 1736
STAT5A -2491
HRAS -8666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIM1 10190
PIK3R1 9177
PTPN11 9106
PIK3CA 8513
NRAS 8452
GRB2 8372
CDKN1A 7780
KRAS 7742
GAB2 7558
FLT3 6373
SOS1 6051
STAT5B 4600
BCL2L1 1736
STAT5A -2491
HRAS -8666


Platelet sensitization by LDL
set Platelet sensitization by LDL
setSize 16
pANOVA 8.9e-05
s.dist 0.566
p.adjustANOVA 0.000919


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK14 9667
PPP2CA 9613
PTPN11 9106
PECAM1 9017
LRP8 8892
FGR 8689
PPP2R5E 8385
PPP2R5A 7897
PPP2CB 6442
PLA2G4A 3927
PTPN6 3707
PPP2R5B 3071
PPP2R1B 2089
PPP2R5C 2065
PPP2R5D 323
PPP2R1A -3185

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK14 9667
PPP2CA 9613
PTPN11 9106
PECAM1 9017
LRP8 8892
FGR 8689
PPP2R5E 8385
PPP2R5A 7897
PPP2CB 6442
PLA2G4A 3927
PTPN6 3707
PPP2R5B 3071
PPP2R1B 2089
PPP2R5C 2065
PPP2R5D 323
PPP2R1A -3185


EGFR Transactivation by Gastrin
set EGFR Transactivation by Gastrin
setSize 7
pANOVA 0.00974
s.dist 0.564
p.adjustANOVA 0.0419


Top enriched genes
Top 20 genes
GeneID Gene Rank
PRKCA 9291
NRAS 8452
GRB2 8372
HBEGF 7903
KRAS 7742
SOS1 6051
HRAS -8666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKCA 9291
NRAS 8452
GRB2 8372
HBEGF 7903
KRAS 7742
SOS1 6051
HRAS -8666


RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
set RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
setSize 7
pANOVA 0.0104
s.dist 0.559
p.adjustANOVA 0.0443


Top enriched genes
Top 20 genes
GeneID Gene Rank
RUNX1 10206
SOCS3 10178
CTSL 10130
CTSV 7451
CBFB 6637
SOCS4 -583
CTSK -5252

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUNX1 10206
SOCS3 10178
CTSL 10130
CTSV 7451
CBFB 6637
SOCS4 -583
CTSK -5252


FBXW7 Mutants and NOTCH1 in Cancer
set FBXW7 Mutants and NOTCH1 in Cancer
setSize 5
pANOVA 0.0306
s.dist 0.558
p.adjustANOVA 0.0987


Top enriched genes
Top 20 genes
GeneID Gene Rank
CUL1 9491
SKP1 9054
FBXW7 8073
RBX1 917
NOTCH1 125

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CUL1 9491
SKP1 9054
FBXW7 8073
RBX1 917
NOTCH1 125


Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
set Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
setSize 5
pANOVA 0.0306
s.dist 0.558
p.adjustANOVA 0.0987


Top enriched genes
Top 20 genes
GeneID Gene Rank
CUL1 9491
SKP1 9054
FBXW7 8073
RBX1 917
NOTCH1 125

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CUL1 9491
SKP1 9054
FBXW7 8073
RBX1 917
NOTCH1 125


Mitotic Telophase/Cytokinesis
set Mitotic Telophase/Cytokinesis
setSize 13
pANOVA 0.000496
s.dist 0.558
p.adjustANOVA 0.00361


Top enriched genes
Top 20 genes
GeneID Gene Rank
NIPBL 9494
RAD21 9429
PDS5A 9380
STAG2 9130
STAG1 9104
PDS5B 8887
WAPL 8590
SMC3 7527
SMC1A 7032
KIF23 2779
KIF20A -74
MAU2 -1773
PLK1 -7699

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NIPBL 9494
RAD21 9429
PDS5A 9380
STAG2 9130
STAG1 9104
PDS5B 8887
WAPL 8590
SMC3 7527
SMC1A 7032
KIF23 2779
KIF20A -74
MAU2 -1773
PLK1 -7699


Regulation of IFNG signaling
set Regulation of IFNG signaling
setSize 14
pANOVA 0.000303
s.dist 0.558
p.adjustANOVA 0.0025


Top enriched genes
Top 20 genes
GeneID Gene Rank
SOCS3 10178
PTPN1 10128
PTPN2 9990
PTPN11 9106
JAK1 8786
SUMO1 8379
IFNGR1 6984
IFNGR2 6805
JAK2 4832
PTPN6 3707
SOCS1 2968
PIAS1 2876
IFNG 1448
STAT1 -8907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SOCS3 10178
PTPN1 10128
PTPN2 9990
PTPN11 9106
JAK1 8786
SUMO1 8379
IFNGR1 6984
IFNGR2 6805
JAK2 4832
PTPN6 3707
SOCS1 2968
PIAS1 2876
IFNG 1448
STAT1 -8907


PI-3K cascade:FGFR3
set PI-3K cascade:FGFR3
setSize 10
pANOVA 0.0031
s.dist 0.54
p.adjustANOVA 0.0167


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIK3R1 9177
PTPN11 9106
FGF2 8708
PIK3CA 8513
GRB2 8372
FGF17 7882
FRS2 6741
GAB1 5835
FGF9 -4804
FGF23 -6167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3R1 9177
PTPN11 9106
FGF2 8708
PIK3CA 8513
GRB2 8372
FGF17 7882
FRS2 6741
GAB1 5835
FGF9 -4804
FGF23 -6167


Negative regulation of activity of TFAP2 (AP-2) family transcription factors
set Negative regulation of activity of TFAP2 (AP-2) family transcription factors
setSize 6
pANOVA 0.0234
s.dist -0.534
p.adjustANOVA 0.0825


Top enriched genes
Top 20 genes
GeneID Gene Rank
KCTD1 -10218
TFAP2E -10175
WWOX -9806
UBE2I -7502
KCTD15 -7143
SUMO1 8379

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCTD1 -10218
TFAP2E -10175
WWOX -9806
UBE2I -7502
KCTD15 -7143
SUMO1 8379


GAB1 signalosome
set GAB1 signalosome
setSize 14
pANOVA 0.00058
s.dist 0.531
p.adjustANOVA 0.00419


Top enriched genes
Top 20 genes
GeneID Gene Rank
PAG1 10173
TGFA 9884
PIK3R1 9177
PTPN11 9106
PIK3CA 8513
GRB2 8372
HBEGF 7903
EGF 6300
GAB1 5835
AREG 3129
PXN 2841
EREG 1382
CSK -1199
SRC -8073

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAG1 10173
TGFA 9884
PIK3R1 9177
PTPN11 9106
PIK3CA 8513
GRB2 8372
HBEGF 7903
EGF 6300
GAB1 5835
AREG 3129
PXN 2841
EREG 1382
CSK -1199
SRC -8073


Response to metal ions
set Response to metal ions
setSize 6
pANOVA 0.0247
s.dist 0.529
p.adjustANOVA 0.0855


Top enriched genes
Top 20 genes
GeneID Gene Rank
MTF1 8723
CSRP1 7947
MT2A 5872
MT1X 3910
MT1E 2922
MT1F 1959

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTF1 8723
CSRP1 7947
MT2A 5872
MT1X 3910
MT1E 2922
MT1F 1959


Maturation of hRSV A proteins
set Maturation of hRSV A proteins
setSize 13
pANOVA 0.00103
s.dist 0.526
p.adjustANOVA 0.00682


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB 10027
CSNK2A1 9255
FURIN 9107
CSNK2A2 8547
XPO1 8451
SPCS3 7448
SPCS1 6809
SPCS2 6568
PPP1CC 5696
CSNK2B 1387
SEC11A -813
PPP1CA -1575
SEC11C -3560

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB 10027
CSNK2A1 9255
FURIN 9107
CSNK2A2 8547
XPO1 8451
SPCS3 7448
SPCS1 6809
SPCS2 6568
PPP1CC 5696
CSNK2B 1387
SEC11A -813
PPP1CA -1575
SEC11C -3560


Displacement of DNA glycosylase by APEX1
set Displacement of DNA glycosylase by APEX1
setSize 9
pANOVA 0.00643
s.dist -0.525
p.adjustANOVA 0.0304


Top enriched genes
Top 20 genes
GeneID Gene Rank
APEX1 -10877
MUTYH -10622
OGG1 -10517
UNG -9964
NTHL1 -9266
SMUG1 -8914
MPG -4126
MBD4 2263
TDG 8267

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APEX1 -10877
MUTYH -10622
OGG1 -10517
UNG -9964
NTHL1 -9266
SMUG1 -8914
MPG -4126
MBD4 2263
TDG 8267


ARMS-mediated activation
set ARMS-mediated activation
setSize 6
pANOVA 0.0264
s.dist 0.524
p.adjustANOVA 0.0896


Top enriched genes
Top 20 genes
GeneID Gene Rank
KIDINS220 8964
RAP1A 8935
YWHAB 8310
BRAF 5844
CRK 3941
NTRK1 -5029

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KIDINS220 8964
RAP1A 8935
YWHAB 8310
BRAF 5844
CRK 3941
NTRK1 -5029


Organic cation transport
set Organic cation transport
setSize 8
pANOVA 0.0104
s.dist 0.523
p.adjustANOVA 0.0442


Top enriched genes
Top 20 genes
GeneID Gene Rank
RUNX1 10206
SLC22A5 8161
SLC22A1 7358
SLC22A4 5784
SLC22A15 5450
RSC1A1 5394
SLC22A16 3773
SLC22A18 -4872

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUNX1 10206
SLC22A5 8161
SLC22A1 7358
SLC22A4 5784
SLC22A15 5450
RSC1A1 5394
SLC22A16 3773
SLC22A18 -4872


Organic cation/anion/zwitterion transport
set Organic cation/anion/zwitterion transport
setSize 8
pANOVA 0.0104
s.dist 0.523
p.adjustANOVA 0.0442


Top enriched genes
Top 20 genes
GeneID Gene Rank
RUNX1 10206
SLC22A5 8161
SLC22A1 7358
SLC22A4 5784
SLC22A15 5450
RSC1A1 5394
SLC22A16 3773
SLC22A18 -4872

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUNX1 10206
SLC22A5 8161
SLC22A1 7358
SLC22A4 5784
SLC22A15 5450
RSC1A1 5394
SLC22A16 3773
SLC22A18 -4872


GRB2 events in EGFR signaling
set GRB2 events in EGFR signaling
setSize 10
pANOVA 0.00491
s.dist 0.514
p.adjustANOVA 0.0239


Top enriched genes
Top 20 genes
GeneID Gene Rank
TGFA 9884
NRAS 8452
GRB2 8372
HBEGF 7903
KRAS 7742
EGF 6300
SOS1 6051
AREG 3129
EREG 1382
HRAS -8666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGFA 9884
NRAS 8452
GRB2 8372
HBEGF 7903
KRAS 7742
EGF 6300
SOS1 6051
AREG 3129
EREG 1382
HRAS -8666


RHOT1 GTPase cycle
set RHOT1 GTPase cycle
setSize 5
pANOVA 0.0467
s.dist 0.514
p.adjustANOVA 0.135


Top enriched genes
Top 20 genes
GeneID Gene Rank
RHOT1 9803
TRAK2 9214
RAP1GDS1 7951
TRAK1 7241
MYO19 -8932

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RHOT1 9803
TRAK2 9214
RAP1GDS1 7951
TRAK1 7241
MYO19 -8932


Uptake and function of diphtheria toxin
set Uptake and function of diphtheria toxin
setSize 6
pANOVA 0.0302
s.dist 0.511
p.adjustANOVA 0.0981


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD9 9640
HSP90AA1 9264
TXNRD1 8092
HBEGF 7903
HSP90AB1 3313
EEF2 -8051

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD9 9640
HSP90AA1 9264
TXNRD1 8092
HBEGF 7903
HSP90AB1 3313
EEF2 -8051


Scavenging by Class F Receptors
set Scavenging by Class F Receptors
setSize 5
pANOVA 0.0483
s.dist 0.51
p.adjustANOVA 0.138


Top enriched genes
Top 20 genes
GeneID Gene Rank
CALR 9987
HSP90AA1 9264
HYOU1 8910
HSPH1 7942
SCARF1 -11023

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CALR 9987
HSP90AA1 9264
HYOU1 8910
HSPH1 7942
SCARF1 -11023


Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
set Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
setSize 16
pANOVA 0.000432
s.dist 0.508
p.adjustANOVA 0.00322


Top enriched genes
Top 20 genes
GeneID Gene Rank
ATP6V1C1 9730
ATP6V1H 9648
ATP6V1A 9134
ATP6AP2 9083
ATP6V1E1 7956
ATP6V1D 7563
ATP6V0E1 7437
ASAH1 6968
ATP6V0A1 5024
ATP6V0B 3016
ATP6V0C 2977
ATP6V1G1 2827
MITF 2117
ATP6V1F -193
ATP6V1B2 -221
ATP6V0E2 -3144

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP6V1C1 9730
ATP6V1H 9648
ATP6V1A 9134
ATP6AP2 9083
ATP6V1E1 7956
ATP6V1D 7563
ATP6V0E1 7437
ASAH1 6968
ATP6V0A1 5024
ATP6V0B 3016
ATP6V0C 2977
ATP6V1G1 2827
MITF 2117
ATP6V1F -193
ATP6V1B2 -221
ATP6V0E2 -3144


Respiratory syncytial virus (RSV) genome replication, transcription and translation
set Respiratory syncytial virus (RSV) genome replication, transcription and translation
setSize 16
pANOVA 0.000476
s.dist 0.504
p.adjustANOVA 0.0035


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB 10027
HSP90AA1 9264
CSNK2A1 9255
FURIN 9107
CSNK2A2 8547
XPO1 8451
SPCS3 7448
SPCS1 6809
SPCS2 6568
PPP1CC 5696
HSP90AB1 3313
CSNK2B 1387
HSPA8 -636
SEC11A -813
PPP1CA -1575
SEC11C -3560

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB 10027
HSP90AA1 9264
CSNK2A1 9255
FURIN 9107
CSNK2A2 8547
XPO1 8451
SPCS3 7448
SPCS1 6809
SPCS2 6568
PPP1CC 5696
HSP90AB1 3313
CSNK2B 1387
HSPA8 -636
SEC11A -813
PPP1CA -1575
SEC11C -3560


SOS-mediated signalling
set SOS-mediated signalling
setSize 7
pANOVA 0.0209
s.dist 0.504
p.adjustANOVA 0.0768


Top enriched genes
Top 20 genes
GeneID Gene Rank
IRS2 8653
NRAS 8452
GRB2 8372
KRAS 7742
SOS1 6051
IRS1 4063
HRAS -8666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 8653
NRAS 8452
GRB2 8372
KRAS 7742
SOS1 6051
IRS1 4063
HRAS -8666


POLB-Dependent Long Patch Base Excision Repair
set POLB-Dependent Long Patch Base Excision Repair
setSize 8
pANOVA 0.0136
s.dist -0.504
p.adjustANOVA 0.0541


Top enriched genes
Top 20 genes
GeneID Gene Rank
APEX1 -10877
LIG1 -8795
FEN1 -8650
ADPRS -7398
PARP2 -7154
PARP1 -4184
PARG -179
POLB 1212

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APEX1 -10877
LIG1 -8795
FEN1 -8650
ADPRS -7398
PARP2 -7154
PARP1 -4184
PARG -179
POLB 1212


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report