date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.8775125
A1BG -0.3089128
A1BG-AS1 0.1740197
A1CF 0.5073348
A2M 0.1365997
A2M-AS1 -0.4476955

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21253
duplicated_genes_present 0
num_profile_genes_in_sets 8700
num_profile_genes_not_in_sets 12553

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1198
num_genesets_included 1527

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Erythrocytes take up oxygen and release carbon dioxide 7 2.45e-04 0.800 3.85e-03
Biosynthesis of Lipoxins (LX) 6 1.89e-03 0.732 1.94e-02
Propionyl-CoA catabolism 5 5.27e-03 -0.721 4.32e-02
Defects of platelet adhesion to exposed collagen 6 6.24e-03 0.645 4.91e-02
Phosphorylation of Emi1 6 7.43e-03 0.631 5.43e-02
Defective GALNT3 causes HFTC 8 2.21e-03 0.625 2.17e-02
Synthesis of wybutosine at G37 of tRNA(Phe) 6 8.73e-03 -0.618 6.03e-02
CD163 mediating an anti-inflammatory response 8 3.11e-03 0.604 2.80e-02
Wax and plasmalogen biosynthesis 5 1.99e-02 -0.601 1.10e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 1.17e-02 0.594 7.60e-02
Defective GALNT12 causes CRCS1 8 3.61e-03 0.594 3.17e-02
Defective binding of VWF variant to GPIb:IX:V 5 2.18e-02 0.592 1.13e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 2.18e-02 0.592 1.13e-01
Response to metal ions 6 1.36e-02 0.582 8.38e-02
Termination of O-glycan biosynthesis 15 1.15e-04 0.575 1.91e-03
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.69e-02 0.572 1.28e-01
PDH complex synthesizes acetyl-CoA from PYR 5 2.93e-02 -0.563 1.36e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 8.45e-04 0.556 1.08e-02
Transport of connexons to the plasma membrane 12 8.45e-04 0.556 1.08e-02
HDL remodeling 6 1.84e-02 0.556 1.03e-01
Type I hemidesmosome assembly 8 6.96e-03 0.551 5.20e-02
SUMO is proteolytically processed 6 1.99e-02 -0.549 1.10e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.28e-02 -0.537 1.16e-01
G2/M DNA replication checkpoint 5 3.79e-02 0.536 1.59e-01
Processing and activation of SUMO 10 3.92e-03 -0.527 3.40e-02
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.35e-02 0.521 1.76e-01
Vitamin B1 (thiamin) metabolism 5 4.37e-02 -0.521 1.76e-01
Regulation of NFE2L2 gene expression 8 1.10e-02 0.519 7.37e-02
CD22 mediated BCR regulation 58 1.01e-11 0.516 1.08e-09
Diseases of branched-chain amino acid catabolism 13 1.32e-03 -0.514 1.49e-02
Repression of WNT target genes 14 8.92e-04 0.513 1.13e-02
RUNX3 regulates WNT signaling 8 1.25e-02 0.510 7.83e-02
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 3.08e-02 0.509 1.40e-01
Anchoring fibril formation 7 1.99e-02 0.508 1.10e-01
Integration of provirus 9 8.40e-03 -0.507 5.92e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 2.08e-02 0.505 1.12e-01
Activation of caspases through apoptosome-mediated cleavage 6 3.23e-02 -0.505 1.44e-01
Synthesis of PIPs at the late endosome membrane 11 3.89e-03 -0.503 3.40e-02
Synthesis of PI 5 5.25e-02 0.501 1.99e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 5.29e-02 -0.500 1.99e-01
Maple Syrup Urine Disease 5 5.29e-02 -0.500 1.99e-01
Alpha-oxidation of phytanate 6 3.53e-02 -0.496 1.51e-01
Formation of xylulose-5-phosphate 5 5.47e-02 -0.496 2.04e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 9.14e-04 0.494 1.14e-02
SMAC (DIABLO) binds to IAPs 7 2.55e-02 -0.488 1.24e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 2.55e-02 -0.488 1.24e-01
SMAC, XIAP-regulated apoptotic response 7 2.55e-02 -0.488 1.24e-01
Phosphate bond hydrolysis by NUDT proteins 7 2.56e-02 -0.487 1.24e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 1.71e-02 0.487 9.88e-02
Heme degradation 10 7.78e-03 0.486 5.60e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Erythrocytes take up oxygen and release carbon dioxide 7 2.45e-04 8.00e-01 3.85e-03
Biosynthesis of Lipoxins (LX) 6 1.89e-03 7.32e-01 1.94e-02
Propionyl-CoA catabolism 5 5.27e-03 -7.21e-01 4.32e-02
Defects of platelet adhesion to exposed collagen 6 6.24e-03 6.45e-01 4.91e-02
Phosphorylation of Emi1 6 7.43e-03 6.31e-01 5.43e-02
Defective GALNT3 causes HFTC 8 2.21e-03 6.25e-01 2.17e-02
Synthesis of wybutosine at G37 of tRNA(Phe) 6 8.73e-03 -6.18e-01 6.03e-02
CD163 mediating an anti-inflammatory response 8 3.11e-03 6.04e-01 2.80e-02
Wax and plasmalogen biosynthesis 5 1.99e-02 -6.01e-01 1.10e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 1.17e-02 5.94e-01 7.60e-02
Defective GALNT12 causes CRCS1 8 3.61e-03 5.94e-01 3.17e-02
Defective binding of VWF variant to GPIb:IX:V 5 2.18e-02 5.92e-01 1.13e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 2.18e-02 5.92e-01 1.13e-01
Response to metal ions 6 1.36e-02 5.82e-01 8.38e-02
Termination of O-glycan biosynthesis 15 1.15e-04 5.75e-01 1.91e-03
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.69e-02 5.72e-01 1.28e-01
PDH complex synthesizes acetyl-CoA from PYR 5 2.93e-02 -5.63e-01 1.36e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 8.45e-04 5.56e-01 1.08e-02
Transport of connexons to the plasma membrane 12 8.45e-04 5.56e-01 1.08e-02
HDL remodeling 6 1.84e-02 5.56e-01 1.03e-01
Type I hemidesmosome assembly 8 6.96e-03 5.51e-01 5.20e-02
SUMO is proteolytically processed 6 1.99e-02 -5.49e-01 1.10e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.28e-02 -5.37e-01 1.16e-01
G2/M DNA replication checkpoint 5 3.79e-02 5.36e-01 1.59e-01
Processing and activation of SUMO 10 3.92e-03 -5.27e-01 3.40e-02
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.35e-02 5.21e-01 1.76e-01
Vitamin B1 (thiamin) metabolism 5 4.37e-02 -5.21e-01 1.76e-01
Regulation of NFE2L2 gene expression 8 1.10e-02 5.19e-01 7.37e-02
CD22 mediated BCR regulation 58 1.01e-11 5.16e-01 1.08e-09
Diseases of branched-chain amino acid catabolism 13 1.32e-03 -5.14e-01 1.49e-02
Repression of WNT target genes 14 8.92e-04 5.13e-01 1.13e-02
RUNX3 regulates WNT signaling 8 1.25e-02 5.10e-01 7.83e-02
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 3.08e-02 5.09e-01 1.40e-01
Anchoring fibril formation 7 1.99e-02 5.08e-01 1.10e-01
Integration of provirus 9 8.40e-03 -5.07e-01 5.92e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 2.08e-02 5.05e-01 1.12e-01
Activation of caspases through apoptosome-mediated cleavage 6 3.23e-02 -5.05e-01 1.44e-01
Synthesis of PIPs at the late endosome membrane 11 3.89e-03 -5.03e-01 3.40e-02
Synthesis of PI 5 5.25e-02 5.01e-01 1.99e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 5.29e-02 -5.00e-01 1.99e-01
Maple Syrup Urine Disease 5 5.29e-02 -5.00e-01 1.99e-01
Alpha-oxidation of phytanate 6 3.53e-02 -4.96e-01 1.51e-01
Formation of xylulose-5-phosphate 5 5.47e-02 -4.96e-01 2.04e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 9.14e-04 4.94e-01 1.14e-02
SMAC (DIABLO) binds to IAPs 7 2.55e-02 -4.88e-01 1.24e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 2.55e-02 -4.88e-01 1.24e-01
SMAC, XIAP-regulated apoptotic response 7 2.55e-02 -4.88e-01 1.24e-01
Phosphate bond hydrolysis by NUDT proteins 7 2.56e-02 -4.87e-01 1.24e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 1.71e-02 4.87e-01 9.88e-02
Heme degradation 10 7.78e-03 4.86e-01 5.60e-02
Acetylcholine binding and downstream events 5 6.00e-02 4.86e-01 2.15e-01
Postsynaptic nicotinic acetylcholine receptors 5 6.00e-02 4.86e-01 2.15e-01
NFE2L2 regulates pentose phosphate pathway genes 8 1.77e-02 4.84e-01 9.99e-02
STAT5 activation downstream of FLT3 ITD mutants 9 1.22e-02 4.83e-01 7.81e-02
ChREBP activates metabolic gene expression 7 2.71e-02 4.82e-01 1.29e-01
Protein lipoylation 10 8.47e-03 -4.81e-01 5.92e-02
Cellular response to mitochondrial stress 9 1.39e-02 -4.73e-01 8.48e-02
Scavenging of heme from plasma 70 8.03e-12 4.72e-01 9.64e-10
NFE2L2 regulating MDR associated enzymes 8 2.17e-02 4.69e-01 1.13e-01
Miscellaneous substrates 7 3.28e-02 4.66e-01 1.45e-01
Regulation of gene expression in beta cells 7 3.38e-02 4.63e-01 1.47e-01
Fibronectin matrix formation 6 5.02e-02 4.62e-01 1.94e-01
Gap junction assembly 16 1.40e-03 4.61e-01 1.54e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 7.53e-02 -4.59e-01 2.54e-01
2-LTR circle formation 7 3.60e-02 -4.58e-01 1.53e-01
Common Pathway of Fibrin Clot Formation 13 4.33e-03 4.57e-01 3.65e-02
Plasma lipoprotein remodeling 18 8.47e-04 4.54e-01 1.08e-02
Classical antibody-mediated complement activation 69 1.35e-10 4.47e-01 9.98e-09
Activation of Matrix Metalloproteinases 20 6.12e-04 4.42e-01 8.64e-03
Cytochrome c-mediated apoptotic response 13 5.93e-03 -4.41e-01 4.70e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.24e-02 -4.35e-01 7.81e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 2.37e-02 4.35e-01 1.18e-01
Adenylate cyclase activating pathway 8 3.32e-02 4.35e-01 1.46e-01
Vitamin C (ascorbate) metabolism 8 3.32e-02 4.35e-01 1.46e-01
Linoleic acid (LA) metabolism 7 4.69e-02 4.34e-01 1.86e-01
NFE2L2 regulating tumorigenic genes 11 1.33e-02 4.31e-01 8.28e-02
Defects in biotin (Btn) metabolism 8 3.49e-02 -4.31e-01 1.50e-01
Synthesis of UDP-N-acetyl-glucosamine 8 3.54e-02 -4.30e-01 1.51e-01
Gamma-carboxylation of protein precursors 6 6.88e-02 4.29e-01 2.38e-01
rRNA modification in the mitochondrion 8 3.57e-02 -4.29e-01 1.52e-01
Translesion synthesis by POLI 17 2.26e-03 -4.28e-01 2.21e-02
Diseases of Mismatch Repair (MMR) 5 9.90e-02 -4.26e-01 3.00e-01
Defective LFNG causes SCDO3 5 1.01e-01 4.24e-01 3.03e-01
Sensing of DNA Double Strand Breaks 6 7.38e-02 -4.21e-01 2.51e-01
SLBP independent Processing of Histone Pre-mRNAs 10 2.11e-02 -4.21e-01 1.13e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 1.98e-07 -4.21e-01 5.95e-06
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 5.40e-02 -4.21e-01 2.02e-01
Translesion synthesis by POLK 17 2.68e-03 -4.20e-01 2.53e-02
Cohesin Loading onto Chromatin 10 2.17e-02 -4.19e-01 1.13e-01
Diseases associated with surfactant metabolism 5 1.05e-01 4.18e-01 3.11e-01
BBSome-mediated cargo-targeting to cilium 23 5.18e-04 -4.18e-01 7.55e-03
Translation initiation complex formation 58 3.84e-08 -4.17e-01 1.29e-06
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.15e-08 -4.16e-01 1.08e-06
Signaling by RNF43 mutants 7 5.65e-02 4.16e-01 2.07e-01
Binding and Uptake of Ligands by Scavenger Receptors 90 9.54e-12 4.15e-01 1.08e-09
EGFR interacts with phospholipase C-gamma 6 7.83e-02 4.15e-01 2.59e-01
Establishment of Sister Chromatid Cohesion 11 1.74e-02 -4.14e-01 9.88e-02
Formation of the active cofactor, UDP-glucuronate 5 1.09e-01 -4.14e-01 3.15e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 6.44e-14 -4.14e-01 1.38e-11
Creation of C4 and C2 activators 71 1.67e-09 4.14e-01 8.00e-08
Early Phase of HIV Life Cycle 14 7.44e-03 -4.13e-01 5.43e-02
MET activates PI3K/AKT signaling 5 1.10e-01 -4.13e-01 3.15e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 1.11e-01 -4.12e-01 3.16e-01
Ribosomal scanning and start codon recognition 58 6.06e-08 -4.11e-01 1.97e-06
GTP hydrolysis and joining of the 60S ribosomal subunit 111 7.17e-14 -4.11e-01 1.38e-11
Netrin mediated repulsion signals 5 1.13e-01 4.10e-01 3.18e-01
Formation of a pool of free 40S subunits 100 1.63e-12 -4.09e-01 2.23e-10
Pexophagy 10 2.65e-02 -4.05e-01 1.27e-01
Erythrocytes take up carbon dioxide and release oxygen 11 2.00e-02 4.05e-01 1.10e-01
O2/CO2 exchange in erythrocytes 11 2.00e-02 4.05e-01 1.10e-01
Deadenylation of mRNA 22 1.02e-03 -4.05e-01 1.24e-02
Diseases of hemostasis 13 1.23e-02 4.01e-01 7.81e-02
Antimicrobial peptides 33 6.81e-05 4.01e-01 1.25e-03
Interaction between L1 and Ankyrins 26 4.07e-04 4.01e-01 6.11e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.24e-02 -4.01e-01 7.81e-02
Cap-dependent Translation Initiation 118 7.02e-14 -3.99e-01 1.38e-11
Eukaryotic Translation Initiation 118 7.02e-14 -3.99e-01 1.38e-11
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.04e-05 -3.98e-01 2.44e-04
Diseases of DNA Double-Strand Break Repair 41 1.04e-05 -3.98e-01 2.44e-04
FCGR activation 76 2.81e-09 3.94e-01 1.20e-07
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.27e-01 -3.94e-01 3.35e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 1.40e-02 3.94e-01 8.50e-02
Synthesis of PIPs at the early endosome membrane 16 6.44e-03 -3.93e-01 4.98e-02
Processing of SMDT1 15 8.41e-03 -3.93e-01 5.92e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 1.28e-01 3.93e-01 3.36e-01
Synthesis of GDP-mannose 6 9.58e-02 3.93e-01 2.95e-01
Translesion synthesis by REV1 16 6.62e-03 -3.92e-01 5.06e-02
Cation-coupled Chloride cotransporters 6 9.67e-02 3.92e-01 2.97e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.07e-12 -3.91e-01 1.58e-10
Cellular hexose transport 14 1.14e-02 3.90e-01 7.48e-02
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.98e-05 -3.90e-01 4.32e-04
Biosynthesis of E-series 18(S)-resolvins 5 1.31e-01 3.90e-01 3.41e-01
G2 Phase 5 1.31e-01 3.90e-01 3.41e-01
Impaired BRCA2 binding to RAD51 35 6.76e-05 -3.89e-01 1.25e-03
Prostanoid ligand receptors 8 5.73e-02 3.88e-01 2.08e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 5.84e-02 3.86e-01 2.11e-01
Mitochondrial translation 96 5.97e-11 -3.86e-01 5.07e-09
Assembly of active LPL and LIPC lipase complexes 10 3.44e-02 3.86e-01 1.49e-01
Regulation of Complement cascade 96 6.15e-11 3.86e-01 5.07e-09
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 7.88e-02 3.84e-01 2.59e-01
Maturation of hRSV A proteins 13 1.66e-02 -3.84e-01 9.78e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 1.05e-01 -3.82e-01 3.11e-01
Small interfering RNA (siRNA) biogenesis 9 4.79e-02 -3.81e-01 1.88e-01
Maturation of protein 3a 9683673 9 4.79e-02 3.81e-01 1.88e-01
Maturation of protein 3a 9694719 9 4.79e-02 3.81e-01 1.88e-01
Aryl hydrocarbon receptor signalling 6 1.06e-01 -3.81e-01 3.13e-01
HDL assembly 6 1.07e-01 3.80e-01 3.13e-01
Selenocysteine synthesis 92 3.28e-10 -3.79e-01 2.25e-08
Synthesis, secretion, and deacylation of Ghrelin 11 2.96e-02 -3.79e-01 1.37e-01
Initial triggering of complement 79 6.04e-09 3.78e-01 2.32e-07
Killing mechanisms 9 4.96e-02 3.78e-01 1.92e-01
WNT5:FZD7-mediated leishmania damping 9 4.96e-02 3.78e-01 1.92e-01
NS1 Mediated Effects on Host Pathways 40 3.56e-05 -3.78e-01 7.52e-04
Branched-chain ketoacid dehydrogenase kinase deficiency 5 1.45e-01 -3.77e-01 3.61e-01
tRNA processing in the mitochondrion 24 1.43e-03 -3.76e-01 1.54e-02
Defective C1GALT1C1 causes TNPS 9 5.11e-02 3.75e-01 1.96e-01
Peptide chain elongation 88 1.19e-09 -3.75e-01 6.01e-08
Formation of apoptosome 11 3.13e-02 -3.75e-01 1.41e-01
Regulation of the apoptosome activity 11 3.13e-02 -3.75e-01 1.41e-01
Mitochondrial translation termination 90 8.02e-10 -3.75e-01 4.67e-08
Eukaryotic Translation Termination 92 5.25e-10 -3.75e-01 3.15e-08
Mitochondrial translation initiation 90 9.17e-10 -3.73e-01 5.04e-08
HDR through Single Strand Annealing (SSA) 37 8.64e-05 -3.73e-01 1.52e-03
Other semaphorin interactions 16 1.02e-02 3.71e-01 6.89e-02
Urea cycle 6 1.16e-01 3.71e-01 3.20e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 2.63e-02 -3.70e-01 1.26e-01
Retinoid metabolism and transport 23 2.10e-03 3.70e-01 2.11e-02
Viral mRNA Translation 88 2.30e-09 -3.68e-01 1.00e-07
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.54e-01 3.68e-01 3.74e-01
Impaired BRCA2 binding to PALB2 24 1.88e-03 -3.67e-01 1.94e-02
Uptake of dietary cobalamins into enterocytes 5 1.56e-01 3.66e-01 3.77e-01
Serotonin Neurotransmitter Release Cycle 15 1.40e-02 3.66e-01 8.50e-02
Defective HLCS causes multiple carboxylase deficiency 7 9.39e-02 -3.66e-01 2.92e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 1.57e-01 3.65e-01 3.79e-01
Fructose metabolism 7 9.45e-02 -3.65e-01 2.93e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 1.03e-09 -3.64e-01 5.48e-08
Gap junction trafficking 27 1.06e-03 3.64e-01 1.27e-02
Cobalamin (Cbl) metabolism 7 9.58e-02 -3.64e-01 2.95e-01
Homologous DNA Pairing and Strand Exchange 43 3.75e-05 -3.63e-01 7.83e-04
PINK1-PRKN Mediated Mitophagy 31 4.67e-04 -3.63e-01 6.85e-03
Eukaryotic Translation Elongation 93 1.42e-09 -3.63e-01 7.01e-08
Nephron development 5 1.61e-01 3.62e-01 3.84e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 1.30e-08 3.61e-01 4.82e-07
PTK6 Regulates Cell Cycle 6 1.26e-01 3.61e-01 3.33e-01
Mitochondrial RNA degradation 25 1.84e-03 -3.60e-01 1.92e-02
Mitochondrial translation elongation 90 3.89e-09 -3.59e-01 1.52e-07
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 6.75e-03 -3.59e-01 5.07e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 3.14e-02 3.59e-01 1.41e-01
N-Glycan antennae elongation 12 3.15e-02 3.59e-01 1.41e-01
Translation 293 9.89e-26 -3.56e-01 9.50e-23
PI3K events in ERBB4 signaling 6 1.34e-01 -3.53e-01 3.45e-01
Class I peroxisomal membrane protein import 20 6.32e-03 -3.53e-01 4.93e-02
WNT mediated activation of DVL 8 8.41e-02 3.53e-01 2.71e-01
Apoptotic cleavage of cell adhesion proteins 8 8.43e-02 -3.52e-01 2.71e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.68e-04 -3.52e-01 8.21e-03
Regulation of beta-cell development 21 5.29e-03 3.52e-01 4.32e-02
Nectin/Necl trans heterodimerization 5 1.74e-01 3.51e-01 4.00e-01
Zinc influx into cells by the SLC39 gene family 9 6.84e-02 3.51e-01 2.38e-01
Formation of the nephric duct 8 8.64e-02 3.50e-01 2.76e-01
Gap junction trafficking and regulation 29 1.12e-03 3.49e-01 1.33e-02
Sodium/Proton exchangers 7 1.10e-01 3.48e-01 3.15e-01
Chondroitin sulfate biosynthesis 12 3.67e-02 3.48e-01 1.55e-01
RHO GTPases activate IQGAPs 25 2.66e-03 3.47e-01 2.53e-02
Biosynthesis of EPA-derived SPMs 6 1.41e-01 3.47e-01 3.55e-01
OAS antiviral response 8 8.99e-02 -3.46e-01 2.83e-01
Post-chaperonin tubulin folding pathway 18 1.11e-02 3.46e-01 7.38e-02
Signal attenuation 9 7.32e-02 3.45e-01 2.50e-01
Inhibition of Signaling by Overexpressed EGFR 5 1.82e-01 3.45e-01 4.13e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 1.82e-01 3.45e-01 4.13e-01
Kinesins 51 2.09e-05 3.44e-01 4.52e-04
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 1.15e-01 3.44e-01 3.20e-01
Defective factor IX causes hemophilia B 6 1.45e-01 3.44e-01 3.61e-01
Complement cascade 100 2.87e-09 3.44e-01 1.20e-07
Transport of RCbl within the body 8 9.25e-02 3.43e-01 2.90e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.97e-03 -3.43e-01 2.68e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.97e-03 -3.43e-01 2.68e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 2.97e-03 -3.43e-01 2.68e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 2.97e-03 -3.43e-01 2.68e-02
CREB3 factors activate genes 6 1.46e-01 -3.43e-01 3.61e-01
FCGR3A-mediated IL10 synthesis 99 3.74e-09 3.43e-01 1.50e-07
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 3.52e-09 -3.42e-01 1.44e-07
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 3.56e-10 -3.40e-01 2.28e-08
Nonsense-Mediated Decay (NMD) 114 3.56e-10 -3.40e-01 2.28e-08
Plasma lipoprotein assembly 10 6.31e-02 3.39e-01 2.22e-01
DNA replication initiation 8 9.69e-02 -3.39e-01 2.97e-01
Androgen biosynthesis 5 1.90e-01 -3.38e-01 4.25e-01
Metabolism of amine-derived hormones 10 6.45e-02 3.38e-01 2.26e-01
SARS-CoV-1 modulates host translation machinery 36 4.66e-04 -3.37e-01 6.85e-03
DNA methylation 18 1.35e-02 3.36e-01 8.32e-02
RHOBTB1 GTPase cycle 23 5.33e-03 -3.36e-01 4.34e-02
Diseases associated with O-glycosylation of proteins 46 8.29e-05 3.35e-01 1.47e-03
A tetrasaccharide linker sequence is required for GAG synthesis 16 2.04e-02 3.35e-01 1.10e-01
Formation of Incision Complex in GG-NER 43 1.45e-04 -3.35e-01 2.35e-03
Prolactin receptor signaling 11 5.60e-02 -3.33e-01 2.06e-01
Glycosphingolipid biosynthesis 16 2.14e-02 3.32e-01 1.13e-01
Translesion Synthesis by POLH 18 1.50e-02 -3.31e-01 8.98e-02
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 2.21e-02 -3.30e-01 1.14e-01
Interleukin-10 signaling 36 6.34e-04 3.29e-01 8.89e-03
ISG15 antiviral mechanism 72 1.42e-06 -3.29e-01 3.78e-05
mRNA Splicing - Major Pathway 203 6.84e-16 -3.28e-01 2.19e-13
mRNA Splicing 211 2.04e-16 -3.28e-01 9.79e-14
Role of phospholipids in phagocytosis 88 1.07e-07 3.28e-01 3.30e-06
Influenza Infection 154 2.38e-12 -3.27e-01 3.05e-10
Diseases of DNA repair 50 6.43e-05 -3.27e-01 1.20e-03
rRNA processing in the mitochondrion 24 5.66e-03 -3.26e-01 4.56e-02
Lysosphingolipid and LPA receptors 11 6.13e-02 3.26e-01 2.17e-01
Influenza Viral RNA Transcription and Replication 135 6.33e-11 -3.26e-01 5.07e-09
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.44e-03 -3.25e-01 1.54e-02
Formation of the beta-catenin:TCF transactivating complex 44 1.92e-04 3.25e-01 3.09e-03
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.05e-02 -3.25e-01 1.10e-01
Signaling by Leptin 10 7.56e-02 3.24e-01 2.54e-01
Crosslinking of collagen fibrils 12 5.17e-02 3.24e-01 1.97e-01
Loss of Function of SMAD2/3 in Cancer 7 1.38e-01 -3.24e-01 3.51e-01
Selenoamino acid metabolism 115 2.02e-09 -3.24e-01 9.47e-08
Transport of the SLBP Dependant Mature mRNA 36 7.97e-04 -3.23e-01 1.06e-02
Vpr-mediated nuclear import of PICs 34 1.14e-03 -3.22e-01 1.34e-02
Elevation of cytosolic Ca2+ levels 13 4.51e-02 3.21e-01 1.81e-01
Role of LAT2/NTAL/LAB on calcium mobilization 77 1.25e-06 3.19e-01 3.37e-05
Deadenylation-dependent mRNA decay 50 9.34e-05 -3.19e-01 1.62e-03
Metabolism of non-coding RNA 53 5.84e-05 -3.19e-01 1.12e-03
snRNP Assembly 53 5.84e-05 -3.19e-01 1.12e-03
Kidney development 16 2.78e-02 3.18e-01 1.31e-01
Keratan sulfate biosynthesis 19 1.67e-02 3.17e-01 9.78e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 1.99e-02 3.17e-01 1.10e-01
mRNA Editing 8 1.22e-01 3.16e-01 3.26e-01
ARMS-mediated activation 6 1.81e-01 -3.16e-01 4.10e-01
Transport of the SLBP independent Mature mRNA 35 1.23e-03 -3.16e-01 1.41e-02
Suppression of apoptosis 7 1.48e-01 3.15e-01 3.65e-01
IRAK2 mediated activation of TAK1 complex 10 8.45e-02 -3.15e-01 2.71e-01
Chemokine receptors bind chemokines 39 6.61e-04 3.15e-01 9.14e-03
Activation of PUMA and translocation to mitochondria 8 1.23e-01 3.15e-01 3.27e-01
Postmitotic nuclear pore complex (NPC) reformation 27 4.67e-03 -3.14e-01 3.90e-02
Metabolism of fat-soluble vitamins 26 5.68e-03 3.13e-01 4.56e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 10 8.72e-02 3.12e-01 2.77e-01
Processing of Capped Intron-Containing Pre-mRNA 279 4.13e-19 -3.11e-01 2.65e-16
InlA-mediated entry of Listeria monocytogenes into host cells 9 1.07e-01 -3.10e-01 3.13e-01
Organic anion transporters 7 1.56e-01 3.09e-01 3.78e-01
CaMK IV-mediated phosphorylation of CREB 8 1.31e-01 -3.09e-01 3.41e-01
Regulation of BACH1 activity 11 7.64e-02 -3.09e-01 2.56e-01
Platelet calcium homeostasis 22 1.23e-02 3.08e-01 7.81e-02
Growth hormone receptor signaling 20 1.71e-02 3.08e-01 9.88e-02
Signaling by TGF-beta Receptor Complex in Cancer 8 1.32e-01 -3.08e-01 3.42e-01
Molecules associated with elastic fibres 26 6.75e-03 3.07e-01 5.07e-02
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 1.94e-01 3.07e-01 4.28e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 1.94e-01 3.07e-01 4.28e-01
p38MAPK events 13 5.57e-02 3.06e-01 2.06e-01
Platelet Adhesion to exposed collagen 14 4.77e-02 3.06e-01 1.88e-01
Interactions of Vpr with host cellular proteins 37 1.32e-03 -3.05e-01 1.49e-02
Platelet Aggregation (Plug Formation) 28 5.21e-03 3.05e-01 4.30e-02
TYSND1 cleaves peroxisomal proteins 7 1.62e-01 -3.05e-01 3.86e-01
Nuclear import of Rev protein 34 2.12e-03 -3.04e-01 2.11e-02
Apoptotic factor-mediated response 19 2.18e-02 -3.04e-01 1.13e-01
HDR through MMEJ (alt-NHEJ) 12 6.93e-02 -3.03e-01 2.39e-01
Anti-inflammatory response favouring Leishmania parasite infection 131 2.29e-09 3.02e-01 1.00e-07
Leishmania parasite growth and survival 131 2.29e-09 3.02e-01 1.00e-07
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 3.10e-02 3.02e-01 1.41e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 3.10e-02 3.02e-01 1.41e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 5.96e-02 3.02e-01 2.14e-01
tRNA processing in the nucleus 59 6.21e-05 -3.01e-01 1.17e-03
Export of Viral Ribonucleoproteins from Nucleus 33 2.78e-03 -3.01e-01 2.60e-02
Formation of Fibrin Clot (Clotting Cascade) 26 8.01e-03 3.00e-01 5.70e-02
Formation of ATP by chemiosmotic coupling 20 2.01e-02 -3.00e-01 1.10e-01
SUMOylation of ubiquitinylation proteins 39 1.20e-03 -3.00e-01 1.39e-02
Elastic fibre formation 33 2.89e-03 3.00e-01 2.66e-02
STAT5 Activation 7 1.71e-01 2.99e-01 3.96e-01
Defective B3GAT3 causes JDSSDHD 10 1.04e-01 2.97e-01 3.09e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 5.56e-02 2.95e-01 2.06e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.46e-05 -2.95e-01 3.30e-04
NOTCH3 Intracellular Domain Regulates Transcription 20 2.23e-02 2.95e-01 1.15e-01
Free fatty acids regulate insulin secretion 10 1.07e-01 2.94e-01 3.13e-01
SUMOylation of SUMOylation proteins 35 2.67e-03 -2.93e-01 2.53e-02
Aspirin ADME 13 6.72e-02 2.93e-01 2.34e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 1.41e-11 -2.93e-01 1.36e-09
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 2.36e-02 -2.92e-01 1.18e-01
SARS-CoV-2 modulates autophagy 11 9.34e-02 -2.92e-01 2.92e-01
Digestion 5 2.58e-01 2.92e-01 5.07e-01
Defective B4GALT7 causes EDS, progeroid type 10 1.11e-01 2.91e-01 3.15e-01
rRNA processing 213 2.38e-13 -2.91e-01 4.15e-11
TNFs bind their physiological receptors 25 1.18e-02 2.91e-01 7.60e-02
Formation of the Editosome 6 2.17e-01 2.91e-01 4.57e-01
mRNA Editing: C to U Conversion 6 2.17e-01 2.91e-01 4.57e-01
Reduction of cytosolic Ca++ levels 9 1.32e-01 2.90e-01 3.43e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 2.50e-02 2.90e-01 1.23e-01
RUNX3 regulates p14-ARF 10 1.13e-01 2.89e-01 3.18e-01
DNA Damage Bypass 47 5.99e-04 -2.89e-01 8.53e-03
Regulation of expression of SLITs and ROBOs 149 1.16e-09 -2.89e-01 6.00e-08
O-linked glycosylation of mucins 46 7.05e-04 2.89e-01 9.67e-03
Mitochondrial Fatty Acid Beta-Oxidation 36 2.74e-03 -2.89e-01 2.56e-02
Branched-chain amino acid catabolism 21 2.22e-02 -2.88e-01 1.14e-01
O-linked glycosylation 81 7.34e-06 2.88e-01 1.79e-04
Synthesis of diphthamide-EEF2 8 1.59e-01 -2.88e-01 3.80e-01
Voltage gated Potassium channels 26 1.11e-02 2.88e-01 7.40e-02
Telomere C-strand synthesis initiation 13 7.27e-02 -2.87e-01 2.49e-01
GP1b-IX-V activation signalling 10 1.16e-01 2.87e-01 3.20e-01
The canonical retinoid cycle in rods (twilight vision) 9 1.36e-01 2.87e-01 3.49e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 5.48e-02 -2.86e-01 2.04e-01
rRNA processing in the nucleus and cytosol 189 1.19e-11 -2.86e-01 1.20e-09
Interactions of Rev with host cellular proteins 37 2.65e-03 -2.86e-01 2.53e-02
Caspase activation via Dependence Receptors in the absence of ligand 9 1.38e-01 2.85e-01 3.51e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 2.73e-02 -2.85e-01 1.29e-01
Butyrophilin (BTN) family interactions 10 1.19e-01 -2.85e-01 3.23e-01
Gluconeogenesis 19 3.20e-02 2.84e-01 1.43e-01
Sema4D in semaphorin signaling 22 2.12e-02 2.84e-01 1.13e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 5.74e-02 2.83e-01 2.08e-01
Sema4D induced cell migration and growth-cone collapse 19 3.26e-02 2.83e-01 1.45e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 2.73e-01 2.83e-01 5.21e-01
POLB-Dependent Long Patch Base Excision Repair 8 1.67e-01 -2.82e-01 3.90e-01
FCERI mediated MAPK activation 93 2.70e-06 2.81e-01 6.73e-05
Modulation by Mtb of host immune system 7 1.98e-01 -2.81e-01 4.33e-01
CDC6 association with the ORC:origin complex 8 1.70e-01 -2.80e-01 3.95e-01
eNOS activation 10 1.25e-01 -2.80e-01 3.30e-01
Mitochondrial protein degradation 96 2.09e-06 -2.80e-01 5.33e-05
Adenylate cyclase inhibitory pathway 11 1.08e-01 2.80e-01 3.14e-01
N-glycan trimming and elongation in the cis-Golgi 5 2.79e-01 -2.80e-01 5.28e-01
ADP signalling through P2Y purinoceptor 1 21 2.70e-02 2.79e-01 1.28e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 2.81e-01 -2.79e-01 5.29e-01
Transcriptional regulation of granulopoiesis 44 1.41e-03 2.78e-01 1.54e-02
Polo-like kinase mediated events 16 5.41e-02 2.78e-01 2.02e-01
Regulation of actin dynamics for phagocytic cup formation 123 1.02e-07 2.78e-01 3.22e-06
Complex I biogenesis 66 9.50e-05 -2.78e-01 1.63e-03
Recognition of DNA damage by PCNA-containing replication complex 30 8.46e-03 -2.78e-01 5.92e-02
Cell surface interactions at the vascular wall 170 4.73e-10 2.77e-01 2.93e-08
Mitochondrial calcium ion transport 22 2.52e-02 -2.76e-01 1.24e-01
Interleukin-2 signaling 11 1.14e-01 2.75e-01 3.19e-01
PKA activation in glucagon signalling 14 7.50e-02 2.75e-01 2.54e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 4.35e-02 -2.75e-01 1.76e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 8.66e-02 2.74e-01 2.76e-01
tRNA processing 128 8.49e-08 -2.74e-01 2.72e-06
Citric acid cycle (TCA cycle) 34 5.69e-03 -2.74e-01 4.56e-02
Activation of the TFAP2 (AP-2) family of transcription factors 7 2.11e-01 2.73e-01 4.52e-01
RNA Polymerase II Transcription Termination 66 1.27e-04 -2.73e-01 2.10e-03
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.16e-02 -2.73e-01 1.97e-01
Termination of translesion DNA synthesis 32 7.77e-03 -2.72e-01 5.60e-02
SARS-CoV-2 modulates host translation machinery 49 9.97e-04 -2.72e-01 1.22e-02
Biotin transport and metabolism 11 1.20e-01 -2.71e-01 3.23e-01
Acyl chain remodelling of PC 19 4.12e-02 2.71e-01 1.69e-01
O-glycosylation of TSR domain-containing proteins 25 1.92e-02 2.71e-01 1.08e-01
Mitophagy 38 4.01e-03 -2.70e-01 3.46e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 2.17e-01 2.69e-01 4.57e-01
FCERI mediated Ca+2 mobilization 92 8.08e-06 2.69e-01 1.94e-04
Apoptosis induced DNA fragmentation 10 1.41e-01 -2.69e-01 3.55e-01
Acetylcholine regulates insulin secretion 9 1.64e-01 2.68e-01 3.88e-01
Estrogen biosynthesis 5 2.99e-01 2.68e-01 5.52e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.37e-02 -2.68e-01 1.47e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.37e-02 -2.68e-01 1.47e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 9.46e-02 2.68e-01 2.93e-01
FCGR3A-mediated phagocytosis 121 3.80e-07 2.67e-01 1.08e-05
Leishmania phagocytosis 121 3.80e-07 2.67e-01 1.08e-05
Parasite infection 121 3.80e-07 2.67e-01 1.08e-05
Signaling by PDGFR in disease 19 4.38e-02 -2.67e-01 1.76e-01
Defective B3GALTL causes PpS 24 2.37e-02 2.67e-01 1.18e-01
Lagging Strand Synthesis 20 3.91e-02 -2.67e-01 1.62e-01
Complex IV assembly 45 1.99e-03 -2.66e-01 2.03e-02
Axonal growth inhibition (RHOA activation) 7 2.24e-01 2.65e-01 4.63e-01
p75NTR regulates axonogenesis 7 2.24e-01 2.65e-01 4.63e-01
Hydrolysis of LPC 8 1.95e-01 2.65e-01 4.28e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 9.84e-02 -2.65e-01 3.00e-01
Keratinization 34 7.63e-03 2.64e-01 5.53e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 1.71e-01 -2.64e-01 3.96e-01
Telomere C-strand (Lagging Strand) Synthesis 34 7.88e-03 -2.63e-01 5.65e-02
Endosomal/Vacuolar pathway 11 1.31e-01 -2.63e-01 3.41e-01
Dual Incision in GG-NER 41 3.55e-03 -2.63e-01 3.14e-02
mRNA 3’-end processing 57 5.91e-04 -2.63e-01 8.47e-03
Transport of Mature Transcript to Cytoplasm 81 4.32e-05 -2.63e-01 8.56e-04
Relaxin receptors 5 3.09e-01 2.63e-01 5.61e-01
Rev-mediated nuclear export of HIV RNA 35 7.40e-03 -2.62e-01 5.43e-02
Formation of the cornified envelope 33 9.66e-03 2.60e-01 6.58e-02
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 2.70e-01 -2.60e-01 5.17e-01
TGFBR1 KD Mutants in Cancer 6 2.70e-01 -2.60e-01 5.17e-01
Extracellular matrix organization 213 5.89e-11 2.60e-01 5.07e-09
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.20e-05 -2.59e-01 8.42e-04
RHO GTPases Activate NADPH Oxidases 21 4.06e-02 2.58e-01 1.67e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.03e-04 -2.58e-01 1.74e-03
Metabolism of RNA 717 5.89e-32 -2.58e-01 1.13e-28
Chondroitin sulfate/dermatan sulfate metabolism 37 7.09e-03 2.56e-01 5.26e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.24e-02 -2.56e-01 7.81e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.24e-02 -2.56e-01 7.81e-02
CREB phosphorylation 7 2.42e-01 -2.55e-01 4.88e-01
VEGF binds to VEGFR leading to receptor dimerization 5 3.23e-01 2.55e-01 5.77e-01
VEGF ligand-receptor interactions 5 3.23e-01 2.55e-01 5.77e-01
Downregulation of ERBB4 signaling 8 2.12e-01 -2.55e-01 4.52e-01
Regulation of signaling by NODAL 6 2.80e-01 -2.54e-01 5.29e-01
Signalling to RAS 19 5.61e-02 2.53e-01 2.06e-01
FOXO-mediated transcription of cell death genes 16 8.03e-02 2.53e-01 2.62e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 8.03e-02 -2.53e-01 2.62e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 2.32e-02 -2.52e-01 1.18e-01
PKA activation 15 9.06e-02 2.52e-01 2.85e-01
Class B/2 (Secretin family receptors) 54 1.34e-03 2.52e-01 1.49e-02
Nuclear Pore Complex (NPC) Disassembly 36 8.85e-03 -2.52e-01 6.09e-02
Interleukin-4 and Interleukin-13 signaling 89 3.93e-05 2.52e-01 8.04e-04
Methylation 13 1.16e-01 -2.52e-01 3.20e-01
Regulation of TP53 Activity through Association with Co-factors 11 1.49e-01 2.52e-01 3.65e-01
Interleukin-7 signaling 21 4.60e-02 2.51e-01 1.84e-01
Transcriptional Regulation by E2F6 34 1.13e-02 -2.51e-01 7.43e-02
Formation of TC-NER Pre-Incision Complex 51 1.96e-03 -2.51e-01 2.00e-02
Loss of Function of TGFBR1 in Cancer 7 2.51e-01 -2.51e-01 4.99e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 4.47e-03 -2.51e-01 3.75e-02
Phase 4 - resting membrane potential 9 1.93e-01 2.50e-01 4.28e-01
Tryptophan catabolism 12 1.33e-01 -2.50e-01 3.44e-01
Pyrimidine salvage 10 1.70e-01 2.50e-01 3.96e-01
Processing of Capped Intronless Pre-mRNA 29 1.98e-02 -2.50e-01 1.10e-01
Respiratory electron transport 149 1.39e-07 -2.50e-01 4.24e-06
Transcriptional regulation of testis differentiation 5 3.33e-01 2.50e-01 5.87e-01
Collagen degradation 41 5.69e-03 2.50e-01 4.56e-02
FBXW7 Mutants and NOTCH1 in Cancer 5 3.34e-01 -2.49e-01 5.87e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 3.34e-01 -2.49e-01 5.87e-01
Ethanol oxidation 6 2.91e-01 -2.49e-01 5.40e-01
Recycling of eIF2:GDP 8 2.24e-01 -2.49e-01 4.63e-01
PERK regulates gene expression 30 1.87e-02 -2.48e-01 1.05e-01
Laminin interactions 25 3.23e-02 2.47e-01 1.44e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 3.63e-02 2.47e-01 1.54e-01
Fructose catabolism 5 3.39e-01 -2.47e-01 5.92e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 5.67e-02 -2.46e-01 2.07e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 8.66e-03 -2.46e-01 6.01e-02
Viral Messenger RNA Synthesis 44 4.76e-03 -2.46e-01 3.96e-02
Alternative complement activation 5 3.42e-01 -2.45e-01 5.92e-01
Synaptic adhesion-like molecules 14 1.13e-01 2.45e-01 3.18e-01
RUNX2 regulates genes involved in cell migration 6 3.02e-01 2.43e-01 5.56e-01
Cargo trafficking to the periciliary membrane 48 3.59e-03 -2.43e-01 3.16e-02
Sulfide oxidation to sulfate 5 3.47e-01 2.43e-01 5.93e-01
PCNA-Dependent Long Patch Base Excision Repair 21 5.40e-02 -2.43e-01 2.02e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 6.48e-03 -2.43e-01 4.98e-02
Signaling by Hippo 18 7.48e-02 -2.43e-01 2.54e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 1.85e-01 -2.42e-01 4.18e-01
Cellular response to starvation 148 3.83e-07 -2.42e-01 1.08e-05
Attachment and Entry 9694614 13 1.31e-01 2.42e-01 3.41e-01
Mitochondrial protein import 63 9.17e-04 -2.41e-01 1.14e-02
SUMOylation of RNA binding proteins 47 4.31e-03 -2.41e-01 3.65e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 1.07e-01 -2.40e-01 3.13e-01
Activation of GABAB receptors 29 2.57e-02 2.39e-01 1.24e-01
GABA B receptor activation 29 2.57e-02 2.39e-01 1.24e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 74 3.73e-04 2.39e-01 5.64e-03
Replacement of protamines by nucleosomes in the male pronucleus 12 1.52e-01 2.39e-01 3.71e-01
Gain-of-function MRAS complexes activate RAF signaling 8 2.43e-01 -2.38e-01 4.88e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 2.43e-01 -2.38e-01 4.88e-01
Signaling by MRAS-complex mutants 8 2.43e-01 -2.38e-01 4.88e-01
Maturation of nucleoprotein 9683610 11 1.72e-01 -2.38e-01 3.96e-01
Zygotic genome activation (ZGA) 5 3.58e-01 2.37e-01 6.03e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 2.16e-03 2.37e-01 2.13e-02
Fcgamma receptor (FCGR) dependent phagocytosis 147 7.55e-07 2.36e-01 2.10e-05
Biosynthesis of specialized proresolving mediators (SPMs) 15 1.14e-01 2.36e-01 3.19e-01
HDR through Homologous Recombination (HRR) 68 7.65e-04 -2.36e-01 1.03e-02
Potassium Channels 62 1.32e-03 2.36e-01 1.49e-02
Proteasome assembly 50 3.93e-03 -2.36e-01 3.40e-02
Signaling by ROBO receptors 189 2.53e-08 -2.35e-01 9.18e-07
TICAM1,TRAF6-dependent induction of TAK1 complex 11 1.78e-01 -2.34e-01 4.06e-01
mRNA Splicing - Minor Pathway 50 4.30e-03 -2.33e-01 3.65e-02
Glutathione synthesis and recycling 10 2.03e-01 2.33e-01 4.39e-01
Dual incision in TC-NER 63 1.42e-03 -2.32e-01 1.54e-02
Glutamate and glutamine metabolism 12 1.64e-01 2.32e-01 3.88e-01
NRIF signals cell death from the nucleus 15 1.21e-01 -2.31e-01 3.25e-01
IRE1alpha activates chaperones 46 6.70e-03 2.31e-01 5.07e-02
XBP1(S) activates chaperone genes 44 8.02e-03 2.31e-01 5.70e-02
Activation of AMPK downstream of NMDARs 20 7.37e-02 2.31e-01 2.51e-01
Cristae formation 33 2.17e-02 -2.31e-01 1.13e-01
AKT phosphorylates targets in the cytosol 14 1.35e-01 2.31e-01 3.46e-01
Creatine metabolism 7 2.91e-01 2.31e-01 5.40e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 1.06e-02 -2.31e-01 7.17e-02
Regulation of IFNA/IFNB signaling 12 1.67e-01 2.30e-01 3.90e-01
Acetylcholine Neurotransmitter Release Cycle 11 1.86e-01 2.30e-01 4.18e-01
Unwinding of DNA 12 1.67e-01 2.30e-01 3.90e-01
RHOBTB3 ATPase cycle 10 2.08e-01 2.30e-01 4.46e-01
Degradation of the extracellular matrix 92 1.44e-04 2.29e-01 2.35e-03
Calcineurin activates NFAT 9 2.34e-01 -2.29e-01 4.78e-01
Complex III assembly 23 5.71e-02 -2.29e-01 2.08e-01
Nucleotide Excision Repair 108 3.89e-05 -2.29e-01 8.03e-04
Peptide ligand-binding receptors 100 7.74e-05 2.29e-01 1.40e-03
ATF4 activates genes in response to endoplasmic reticulum stress 25 4.80e-02 -2.28e-01 1.88e-01
Vitamin B2 (riboflavin) metabolism 6 3.33e-01 2.28e-01 5.87e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 3.34e-01 2.28e-01 5.87e-01
Aerobic respiration and respiratory electron transport 245 8.72e-10 -2.27e-01 4.93e-08
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 3.35e-01 2.27e-01 5.88e-01
Semaphorin interactions 56 3.25e-03 2.27e-01 2.91e-02
Glucuronidation 8 2.66e-01 -2.27e-01 5.14e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 2.98e-01 -2.27e-01 5.51e-01
Dermatan sulfate biosynthesis 6 3.36e-01 2.27e-01 5.88e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 5.00e-02 -2.26e-01 1.93e-01
Synthesis of PIPs at the ER membrane 5 3.82e-01 -2.26e-01 6.23e-01
Signaling by ALK 24 5.57e-02 2.26e-01 2.06e-01
Factors involved in megakaryocyte development and platelet production 128 1.17e-05 2.24e-01 2.71e-04
Interferon alpha/beta signaling 63 2.10e-03 -2.24e-01 2.11e-02
Attenuation phase 22 6.91e-02 2.24e-01 2.39e-01
LTC4-CYSLTR mediated IL4 production 5 3.88e-01 -2.23e-01 6.31e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 5.37e-02 -2.23e-01 2.01e-01
Gap junction degradation 11 2.02e-01 2.22e-01 4.39e-01
Collagen formation 63 2.32e-03 2.22e-01 2.25e-02
Leishmania infection 210 3.11e-08 2.22e-01 1.08e-06
Parasitic Infection Pathways 210 3.11e-08 2.22e-01 1.08e-06
Glucagon signaling in metabolic regulation 26 5.06e-02 2.21e-01 1.95e-01
Negative regulators of DDX58/IFIH1 signaling 34 2.55e-02 -2.21e-01 1.24e-01
Keratan sulfate/keratin metabolism 27 4.83e-02 2.20e-01 1.89e-01
Inwardly rectifying K+ channels 22 7.52e-02 2.19e-01 2.54e-01
Translocation of ZAP-70 to Immunological synapse 24 6.33e-02 -2.19e-01 2.23e-01
Listeria monocytogenes entry into host cells 17 1.18e-01 -2.19e-01 3.22e-01
Pre-NOTCH Processing in Golgi 18 1.11e-01 2.17e-01 3.15e-01
SUMOylation of DNA damage response and repair proteins 77 9.81e-04 -2.17e-01 1.21e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 34 2.88e-02 -2.17e-01 1.34e-01
Arachidonate metabolism 42 1.52e-02 2.17e-01 9.01e-02
Norepinephrine Neurotransmitter Release Cycle 14 1.61e-01 2.16e-01 3.84e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.34e-01 -2.16e-01 3.45e-01
ER Quality Control Compartment (ERQC) 21 8.64e-02 -2.16e-01 2.76e-01
ERBB2 Regulates Cell Motility 10 2.37e-01 -2.16e-01 4.82e-01
Formation of annular gap junctions 10 2.37e-01 2.16e-01 4.82e-01
APC-Cdc20 mediated degradation of Nek2A 26 5.67e-02 -2.16e-01 2.07e-01
Germ layer formation at gastrulation 9 2.62e-01 -2.16e-01 5.11e-01
RHOBTB GTPase Cycle 35 2.73e-02 -2.16e-01 1.29e-01
Hyaluronan metabolism 15 1.49e-01 2.15e-01 3.65e-01
RUNX3 regulates NOTCH signaling 14 1.64e-01 2.15e-01 3.88e-01
GPCR ligand binding 241 9.38e-09 2.15e-01 3.53e-07
Removal of the Flap Intermediate 14 1.65e-01 -2.14e-01 3.88e-01
Class A/1 (Rhodopsin-like receptors) 176 9.15e-07 2.14e-01 2.51e-05
Activation of G protein gated Potassium channels 18 1.16e-01 2.14e-01 3.20e-01
G protein gated Potassium channels 18 1.16e-01 2.14e-01 3.20e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 1.16e-01 2.14e-01 3.20e-01
Thyroxine biosynthesis 5 4.07e-01 2.14e-01 6.51e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.41e-01 -2.14e-01 4.88e-01
The activation of arylsulfatases 10 2.42e-01 -2.14e-01 4.88e-01
Nuclear events stimulated by ALK signaling in cancer 33 3.39e-02 2.13e-01 1.47e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 9.92e-02 -2.13e-01 3.00e-01
Metabolism of porphyrins 22 8.39e-02 2.13e-01 2.71e-01
Processing of Intronless Pre-mRNAs 20 9.96e-02 -2.13e-01 3.01e-01
HSF1-dependent transactivation 28 5.19e-02 2.12e-01 1.97e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.20e-01 -2.12e-01 3.23e-01
Phospholipase C-mediated cascade; FGFR4 6 3.70e-01 2.12e-01 6.15e-01
Neurofascin interactions 5 4.13e-01 2.12e-01 6.56e-01
Digestion and absorption 7 3.33e-01 2.11e-01 5.87e-01
Post-translational protein phosphorylation 67 2.80e-03 2.11e-01 2.60e-02
Regulation of Apoptosis 40 2.10e-02 -2.11e-01 1.12e-01
Protein localization 157 5.16e-06 -2.11e-01 1.27e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 5.37e-02 2.11e-01 2.01e-01
Olfactory Signaling Pathway 54 7.48e-03 2.10e-01 5.44e-02
SARS-CoV-1-host interactions 94 4.24e-04 -2.10e-01 6.32e-03
Vpu mediated degradation of CD4 39 2.37e-02 -2.09e-01 1.18e-01
G0 and Early G1 27 6.01e-02 2.09e-01 2.15e-01
NOTCH2 intracellular domain regulates transcription 11 2.31e-01 2.09e-01 4.73e-01
Activation of SMO 14 1.77e-01 2.08e-01 4.05e-01
Metabolism of Angiotensinogen to Angiotensins 12 2.13e-01 2.08e-01 4.52e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 107 2.06e-04 -2.08e-01 3.30e-03
rRNA modification in the nucleus and cytosol 59 5.94e-03 -2.07e-01 4.70e-02
Assembly of collagen fibrils and other multimeric structures 41 2.18e-02 2.07e-01 1.13e-01
Dopamine Neurotransmitter Release Cycle 20 1.09e-01 2.07e-01 3.15e-01
Protein methylation 15 1.66e-01 -2.07e-01 3.89e-01
Phenylalanine metabolism 5 4.24e-01 -2.06e-01 6.63e-01
Regulation of CDH11 function 9 2.84e-01 2.06e-01 5.33e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 183 1.52e-06 2.06e-01 4.01e-05
FGFRL1 modulation of FGFR1 signaling 7 3.45e-01 2.06e-01 5.92e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 2.11e-02 -2.06e-01 1.13e-01
Downstream TCR signaling 89 8.04e-04 -2.06e-01 1.06e-02
SARS-CoV-2-host interactions 181 1.89e-06 -2.05e-01 4.89e-05
Carboxyterminal post-translational modifications of tubulin 33 4.14e-02 2.05e-01 1.69e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 3.47e-01 2.05e-01 5.93e-01
HIV Transcription Initiation 45 1.74e-02 -2.05e-01 9.88e-02
RNA Polymerase II HIV Promoter Escape 45 1.74e-02 -2.05e-01 9.88e-02
RNA Polymerase II Promoter Escape 45 1.74e-02 -2.05e-01 9.88e-02
RNA Polymerase II Transcription Initiation 45 1.74e-02 -2.05e-01 9.88e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.74e-02 -2.05e-01 9.88e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.74e-02 -2.05e-01 9.88e-02
Acyl chain remodelling of PG 11 2.40e-01 2.05e-01 4.85e-01
PI-3K cascade:FGFR3 10 2.63e-01 -2.05e-01 5.11e-01
Cell-extracellular matrix interactions 15 1.71e-01 2.04e-01 3.96e-01
RNA Polymerase I Promoter Opening 17 1.46e-01 2.04e-01 3.61e-01
Recycling pathway of L1 40 2.61e-02 2.03e-01 1.25e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 1.29e-02 2.03e-01 8.09e-02
Hemostasis 553 2.99e-16 2.03e-01 1.15e-13
Activation of RAC1 downstream of NMDARs 7 3.52e-01 2.03e-01 5.97e-01
Ubiquinol biosynthesis 13 2.05e-01 -2.03e-01 4.43e-01
Methionine salvage pathway 6 3.90e-01 -2.03e-01 6.32e-01
RHOBTB2 GTPase cycle 23 9.26e-02 -2.03e-01 2.90e-01
G alpha (s) signalling events 93 7.44e-04 2.02e-01 1.01e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 10 2.70e-01 2.01e-01 5.17e-01
Formation of tubulin folding intermediates by CCT/TriC 21 1.13e-01 2.00e-01 3.18e-01
CD28 dependent Vav1 pathway 12 2.33e-01 -1.99e-01 4.77e-01
Regulation of CDH11 gene transcription 5 4.42e-01 1.99e-01 6.73e-01
Polymerase switching on the C-strand of the telomere 26 7.97e-02 -1.99e-01 2.62e-01
G alpha (z) signalling events 36 3.94e-02 1.98e-01 1.63e-01
IKK complex recruitment mediated by RIP1 23 9.99e-02 -1.98e-01 3.01e-01
Scavenging by Class F Receptors 5 4.43e-01 1.98e-01 6.74e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 3.04e-01 1.98e-01 5.58e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.57e-01 -1.97e-01 5.04e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 7.19e-03 -1.97e-01 5.31e-02
Unblocking of NMDA receptors, glutamate binding and activation 12 2.38e-01 -1.97e-01 4.83e-01
Glutamate Neurotransmitter Release Cycle 20 1.27e-01 1.97e-01 3.35e-01
Basigin interactions 21 1.18e-01 1.97e-01 3.23e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 3.07e-01 1.97e-01 5.61e-01
Organic cation transport 8 3.36e-01 1.96e-01 5.88e-01
Organic cation/anion/zwitterion transport 8 3.36e-01 1.96e-01 5.88e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 7.72e-02 1.96e-01 2.56e-01
Regulation of PTEN localization 9 3.08e-01 -1.96e-01 5.61e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 2.06e-01 1.95e-01 4.43e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 2.06e-01 1.95e-01 4.43e-01
Collagen biosynthesis and modifying enzymes 45 2.35e-02 1.95e-01 1.18e-01
Stabilization of p53 43 2.68e-02 -1.95e-01 1.28e-01
RUNX2 regulates bone development 21 1.22e-01 1.95e-01 3.26e-01
SUMOylation of chromatin organization proteins 57 1.10e-02 -1.95e-01 7.37e-02
HIV Life Cycle 144 5.95e-05 -1.94e-01 1.13e-03
Processive synthesis on the lagging strand 15 1.94e-01 -1.94e-01 4.28e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 1.39e-02 -1.94e-01 8.48e-02
IRAK1 recruits IKK complex 14 2.11e-01 -1.93e-01 4.50e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 2.11e-01 -1.93e-01 4.50e-01
MET activates RAP1 and RAC1 10 2.91e-01 -1.93e-01 5.40e-01
Regulation of insulin secretion 62 8.63e-03 1.93e-01 6.01e-02
Respiratory Syncytial Virus Infection Pathway 97 1.05e-03 -1.93e-01 1.27e-02
Glycosaminoglycan metabolism 95 1.19e-03 1.92e-01 1.39e-02
NIK–>noncanonical NF-kB signaling 46 2.40e-02 -1.92e-01 1.19e-01
Leading Strand Synthesis 14 2.13e-01 -1.92e-01 4.52e-01
Polymerase switching 14 2.13e-01 -1.92e-01 4.52e-01
Synthesis of PIPs at the Golgi membrane 16 1.83e-01 -1.92e-01 4.15e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 2.31e-01 -1.92e-01 4.73e-01
Regulation of RUNX2 expression and activity 54 1.50e-02 -1.91e-01 8.98e-02
Peroxisomal protein import 58 1.17e-02 -1.91e-01 7.60e-02
Integrin signaling 22 1.20e-01 1.91e-01 3.25e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.52e-01 1.91e-01 5.01e-01
alpha-linolenic acid (ALA) metabolism 12 2.52e-01 1.91e-01 5.01e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 7.56e-02 -1.91e-01 2.54e-01
Regulation of RUNX1 Expression and Activity 18 1.61e-01 1.91e-01 3.84e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 2.17e-01 -1.91e-01 4.57e-01
RHO GTPases activate KTN1 11 2.76e-01 1.90e-01 5.23e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.76e-01 -1.90e-01 5.24e-01
Fanconi Anemia Pathway 36 4.91e-02 -1.90e-01 1.91e-01
Nuclear Receptor transcription pathway 38 4.33e-02 1.89e-01 1.76e-01
Integration of energy metabolism 87 2.26e-03 1.89e-01 2.21e-02
DNA Damage Recognition in GG-NER 38 4.35e-02 -1.89e-01 1.76e-01
Base-Excision Repair, AP Site Formation 28 8.31e-02 1.89e-01 2.70e-01
Suppression of phagosomal maturation 12 2.57e-01 -1.89e-01 5.04e-01
L1CAM interactions 100 1.10e-03 1.89e-01 1.31e-02
Defective CFTR causes cystic fibrosis 47 2.52e-02 -1.89e-01 1.24e-01
RAF activation 32 6.55e-02 -1.88e-01 2.28e-01
Estrogen-stimulated signaling through PRKCZ 6 4.27e-01 -1.87e-01 6.65e-01
Negative regulation of FLT3 15 2.09e-01 1.87e-01 4.49e-01
Metabolism of nitric oxide: NOS3 activation and regulation 13 2.43e-01 -1.87e-01 4.88e-01
APC/C:Cdc20 mediated degradation of Securin 55 1.63e-02 -1.87e-01 9.63e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 4.69e-01 -1.87e-01 6.98e-01
Non-integrin membrane-ECM interactions 46 2.82e-02 1.87e-01 1.32e-01
Signaling by NOTCH3 42 3.65e-02 1.87e-01 1.54e-01
Phase 0 - rapid depolarisation 23 1.22e-01 1.86e-01 3.26e-01
Nef Mediated CD8 Down-regulation 7 3.93e-01 1.86e-01 6.37e-01
Beta-oxidation of pristanoyl-CoA 9 3.35e-01 -1.85e-01 5.88e-01
Induction of Cell-Cell Fusion 8 3.65e-01 1.85e-01 6.12e-01
Hyaluronan uptake and degradation 12 2.68e-01 1.85e-01 5.15e-01
Bicarbonate transporters 9 3.38e-01 -1.85e-01 5.90e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.18e-01 -1.84e-01 3.22e-01
Phosphorylation of the APC/C 20 1.54e-01 -1.84e-01 3.74e-01
Regulation of PTEN mRNA translation 12 2.70e-01 -1.84e-01 5.17e-01
SUMOylation of immune response proteins 12 2.70e-01 1.84e-01 5.17e-01
Resolution of D-Loop Structures 35 6.05e-02 -1.83e-01 2.15e-01
PI3K events in ERBB2 signaling 11 2.94e-01 -1.83e-01 5.44e-01
SARS-CoV-1 Infection 137 2.20e-04 -1.83e-01 3.50e-03
RUNX1 regulates estrogen receptor mediated transcription 6 4.38e-01 1.83e-01 6.73e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.06e-01 -1.83e-01 4.43e-01
Signaling by MST1 5 4.79e-01 1.83e-01 7.02e-01
Other interleukin signaling 18 1.81e-01 1.82e-01 4.11e-01
Transport of nucleotide sugars 9 3.46e-01 -1.81e-01 5.92e-01
HDMs demethylate histones 22 1.41e-01 1.81e-01 3.55e-01
Interleukin-9 signaling 8 3.76e-01 1.81e-01 6.19e-01
tRNA modification in the nucleus and cytosol 43 4.04e-02 -1.81e-01 1.67e-01
E2F mediated regulation of DNA replication 22 1.44e-01 -1.80e-01 3.59e-01
Cleavage of the damaged pyrimidine 26 1.13e-01 1.80e-01 3.18e-01
Depyrimidination 26 1.13e-01 1.80e-01 3.18e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 1.13e-01 1.80e-01 3.18e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 4.46e-01 1.80e-01 6.76e-01
Signaling by GPCR 441 1.04e-10 1.79e-01 7.97e-09
Recycling of bile acids and salts 8 3.80e-01 1.79e-01 6.23e-01
Mitotic Spindle Checkpoint 107 1.43e-03 -1.78e-01 1.54e-02
Phosphorylation of CD3 and TCR zeta chains 27 1.09e-01 -1.78e-01 3.15e-01
PTK6 promotes HIF1A stabilization 6 4.50e-01 -1.78e-01 6.79e-01
GPER1 signaling 38 5.78e-02 1.78e-01 2.09e-01
Folding of actin by CCT/TriC 10 3.30e-01 -1.78e-01 5.86e-01
RA biosynthesis pathway 13 2.67e-01 -1.78e-01 5.14e-01
AKT phosphorylates targets in the nucleus 9 3.56e-01 1.78e-01 6.01e-01
Defects in vitamin and cofactor metabolism 21 1.60e-01 -1.77e-01 3.84e-01
APOBEC3G mediated resistance to HIV-1 infection 5 4.95e-01 -1.76e-01 7.13e-01
Mitotic Telophase/Cytokinesis 13 2.71e-01 -1.76e-01 5.18e-01
NADE modulates death signalling 5 4.96e-01 -1.76e-01 7.14e-01
SUMOylation of DNA methylation proteins 16 2.23e-01 1.76e-01 4.63e-01
Ca2+ activated K+ channels 6 4.56e-01 1.76e-01 6.86e-01
NFE2L2 regulating ER-stress associated genes 5 4.96e-01 1.76e-01 7.14e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 3.23e-02 1.75e-01 1.44e-01
Expression and translocation of olfactory receptors 49 3.41e-02 1.75e-01 1.48e-01
Dectin-1 mediated noncanonical NF-kB signaling 47 3.82e-02 -1.75e-01 1.59e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.58e-01 -1.74e-01 3.79e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 1.49e-01 1.74e-01 3.65e-01
RET signaling 32 8.88e-02 1.74e-01 2.81e-01
RNA polymerase II transcribes snRNA genes 71 1.14e-02 -1.74e-01 7.47e-02
Aspartate and asparagine metabolism 8 3.95e-01 -1.74e-01 6.38e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 5.02e-01 -1.73e-01 7.17e-01
NRAGE signals death through JNK 52 3.05e-02 1.73e-01 1.40e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 2.62e-01 -1.73e-01 5.10e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 9 3.69e-01 1.73e-01 6.15e-01
Defective EXT2 causes exostoses 2 9 3.69e-01 1.73e-01 6.15e-01
Metabolism of cofactors 25 1.34e-01 -1.73e-01 3.45e-01
TNFR1-induced proapoptotic signaling 24 1.42e-01 1.73e-01 3.57e-01
SUMOylation of transcription factors 16 2.31e-01 -1.73e-01 4.73e-01
Regulation of CDH19 Expression and Function 5 5.03e-01 1.73e-01 7.18e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 2.18e-01 -1.73e-01 4.58e-01
Late Phase of HIV Life Cycle 131 6.51e-04 -1.73e-01 9.06e-03
Signal amplification 28 1.14e-01 1.72e-01 3.20e-01
Reversible hydration of carbon dioxide 8 3.99e-01 1.72e-01 6.42e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 3.02e-01 1.72e-01 5.56e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.37e-01 1.72e-01 3.50e-01
Alpha-protein kinase 1 signaling pathway 11 3.24e-01 -1.72e-01 5.77e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 2.35e-01 1.71e-01 4.80e-01
Degradation of GLI2 by the proteasome 45 4.67e-02 -1.71e-01 1.85e-01
GLI3 is processed to GLI3R by the proteasome 45 4.67e-02 -1.71e-01 1.85e-01
Potential therapeutics for SARS 148 3.33e-04 1.71e-01 5.07e-03
IFNG signaling activates MAPKs 8 4.03e-01 -1.71e-01 6.46e-01
Regulation of HMOX1 expression and activity 5 5.09e-01 1.71e-01 7.22e-01
CRMPs in Sema3A signaling 13 2.87e-01 1.71e-01 5.35e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 7.27e-02 -1.70e-01 2.49e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 3.51e-01 -1.70e-01 5.96e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 1.99e-01 -1.70e-01 4.35e-01
Mismatch Repair 15 2.54e-01 -1.70e-01 5.02e-01
Vif-mediated degradation of APOBEC3G 41 5.97e-02 -1.70e-01 2.14e-01
GABA receptor activation 35 8.20e-02 1.70e-01 2.67e-01
Cardiac conduction 88 5.91e-03 1.70e-01 4.70e-02
Platelet homeostasis 69 1.48e-02 1.70e-01 8.97e-02
Activation of NF-kappaB in B cells 54 3.14e-02 -1.69e-01 1.41e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.21e-01 -1.69e-01 3.25e-01
Tight junction interactions 17 2.27e-01 -1.69e-01 4.68e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.28e-01 -1.69e-01 3.36e-01
Host Interactions of HIV factors 118 1.52e-03 -1.69e-01 1.61e-02
Negative regulation of NOTCH4 signaling 44 5.28e-02 -1.69e-01 1.99e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.10e-01 -1.68e-01 3.15e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 1.30e-01 1.68e-01 3.41e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 4.41e-01 1.68e-01 6.73e-01
Regulation of TP53 Activity through Phosphorylation 88 6.46e-03 -1.68e-01 4.98e-02
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 60 2.45e-02 1.68e-01 1.22e-01
FGFR2b ligand binding and activation 6 4.77e-01 1.68e-01 7.00e-01
Fatty acids 6 4.77e-01 1.68e-01 7.01e-01
Adherens junctions interactions 37 7.85e-02 1.67e-01 2.59e-01
RSV-host interactions 76 1.18e-02 -1.67e-01 7.60e-02
Protein repair 6 4.80e-01 1.67e-01 7.02e-01
Degradation of cysteine and homocysteine 12 3.18e-01 1.66e-01 5.72e-01
HIV Infection 213 3.10e-05 -1.66e-01 6.62e-04
Acyl chain remodelling of PI 10 3.65e-01 1.65e-01 6.12e-01
Integrin cell surface interactions 64 2.24e-02 1.65e-01 1.15e-01
Nuclear Envelope Breakdown 53 3.80e-02 -1.65e-01 1.59e-01
Mitochondrial iron-sulfur cluster biogenesis 13 3.04e-01 -1.65e-01 5.58e-01
G alpha (q) signalling events 139 8.09e-04 1.65e-01 1.06e-02
Cleavage of the damaged purine 21 1.92e-01 1.65e-01 4.26e-01
Depurination 21 1.92e-01 1.65e-01 4.26e-01
Recognition and association of DNA glycosylase with site containing an affected purine 21 1.92e-01 1.65e-01 4.26e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.39e-01 1.65e-01 3.51e-01
Triglyceride biosynthesis 9 3.93e-01 1.64e-01 6.37e-01
Biosynthesis of DHA-derived SPMs 13 3.07e-01 1.64e-01 5.61e-01
Serine biosynthesis 8 4.23e-01 1.63e-01 6.63e-01
PI-3K cascade:FGFR2 13 3.08e-01 -1.63e-01 5.61e-01
Signaling by activated point mutants of FGFR1 5 5.27e-01 1.63e-01 7.30e-01
Intrinsic Pathway of Fibrin Clot Formation 15 2.73e-01 1.63e-01 5.21e-01
Sphingolipid catabolism 11 3.49e-01 1.63e-01 5.94e-01
E2F-enabled inhibition of pre-replication complex formation 9 3.98e-01 -1.63e-01 6.41e-01
G alpha (12/13) signalling events 68 2.03e-02 1.63e-01 1.10e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 4.26e-01 1.63e-01 6.64e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 9.60e-02 -1.63e-01 2.96e-01
SOS-mediated signalling 7 4.57e-01 1.62e-01 6.87e-01
Striated Muscle Contraction 25 1.61e-01 1.62e-01 3.84e-01
DAP12 signaling 28 1.38e-01 -1.62e-01 3.51e-01
Diseases of glycosylation 104 4.34e-03 1.62e-01 3.65e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 2.63e-01 1.62e-01 5.11e-01
ER-Phagosome pathway 74 1.62e-02 -1.62e-01 9.60e-02
The phototransduction cascade 26 1.54e-01 -1.62e-01 3.74e-01
Carnitine shuttle 12 3.33e-01 1.61e-01 5.87e-01
Depolymerization of the Nuclear Lamina 15 2.79e-01 1.61e-01 5.28e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 7.03e-02 -1.61e-01 2.42e-01
Transcription of the HIV genome 67 2.24e-02 -1.61e-01 1.15e-01
Muscle contraction 142 9.07e-04 1.61e-01 1.14e-02
Netrin-1 signaling 34 1.04e-01 1.61e-01 3.09e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 4.30e-01 1.61e-01 6.67e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 4.64e-02 -1.61e-01 1.85e-01
Signaling by high-kinase activity BRAF mutants 33 1.09e-01 1.61e-01 3.15e-01
Surfactant metabolism 20 2.12e-01 1.61e-01 4.52e-01
Signaling by FLT3 ITD and TKD mutants 15 2.82e-01 1.60e-01 5.31e-01
Signaling by FGFR1 in disease 32 1.17e-01 -1.60e-01 3.20e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 4.97e-01 1.60e-01 7.15e-01
Insulin processing 19 2.28e-01 -1.60e-01 4.69e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 1.07e-01 1.60e-01 3.13e-01
Synthesis of PC 23 1.86e-01 -1.59e-01 4.18e-01
Assembly and cell surface presentation of NMDA receptors 30 1.31e-01 1.59e-01 3.41e-01
FGFR1 mutant receptor activation 25 1.68e-01 -1.59e-01 3.91e-01
Downstream signaling events of B Cell Receptor (BCR) 68 2.36e-02 -1.59e-01 1.18e-01
GPCR downstream signalling 396 5.95e-08 1.59e-01 1.97e-06
Regulation of HSF1-mediated heat shock response 78 1.55e-02 -1.59e-01 9.19e-02
DNA Damage/Telomere Stress Induced Senescence 42 7.62e-02 1.58e-01 2.55e-01
Myogenesis 20 2.21e-01 1.58e-01 4.61e-01
Degradation of AXIN 42 7.67e-02 -1.58e-01 2.56e-01
Acyl chain remodelling of PS 14 3.07e-01 1.58e-01 5.61e-01
Neurexins and neuroligins 35 1.07e-01 1.58e-01 3.13e-01
Macroautophagy 128 2.11e-03 -1.57e-01 2.11e-02
Signaling by FGFR2 in disease 33 1.18e-01 -1.57e-01 3.22e-01
Thromboxane signalling through TP receptor 20 2.23e-01 1.57e-01 4.63e-01
IRF3-mediated induction of type I IFN 12 3.46e-01 -1.57e-01 5.92e-01
Aquaporin-mediated transport 38 9.39e-02 1.57e-01 2.92e-01
RHOB GTPase cycle 64 3.00e-02 1.57e-01 1.38e-01
Eicosanoids 6 5.08e-01 1.56e-01 7.22e-01
Interleukin-37 signaling 19 2.40e-01 1.56e-01 4.85e-01
Lipophagy 7 4.76e-01 -1.56e-01 7.00e-01
RHOC GTPase cycle 71 2.35e-02 1.55e-01 1.18e-01
Phospholipase C-mediated cascade; FGFR3 5 5.47e-01 1.55e-01 7.42e-01
Neuronal System 262 1.50e-05 1.55e-01 3.34e-04
Hh mutants are degraded by ERAD 42 8.24e-02 -1.55e-01 2.68e-01
TCR signaling 110 5.02e-03 -1.55e-01 4.16e-02
Autodegradation of the E3 ubiquitin ligase COP1 38 9.92e-02 -1.55e-01 3.00e-01
Calnexin/calreticulin cycle 26 1.73e-01 -1.54e-01 3.98e-01
SUMOylation of DNA replication proteins 46 7.01e-02 -1.54e-01 2.42e-01
Amine ligand-binding receptors 10 3.99e-01 1.54e-01 6.42e-01
Antiviral mechanism by IFN-stimulated genes 140 1.66e-03 -1.54e-01 1.74e-02
GAB1 signalosome 14 3.20e-01 1.54e-01 5.75e-01
FLT3 signaling through SRC family kinases 6 5.15e-01 1.53e-01 7.25e-01
Protein-protein interactions at synapses 54 5.12e-02 1.53e-01 1.96e-01
Signaling by FGFR3 in disease 14 3.21e-01 -1.53e-01 5.75e-01
Neddylation 215 1.08e-04 -1.53e-01 1.81e-03
Regulation of TP53 Activity through Methylation 19 2.48e-01 -1.53e-01 4.95e-01
Effects of PIP2 hydrolysis 24 1.95e-01 1.53e-01 4.30e-01
mRNA Capping 29 1.55e-01 -1.53e-01 3.76e-01
Activation of the AP-1 family of transcription factors 10 4.05e-01 1.52e-01 6.48e-01
Phospholipase C-mediated cascade: FGFR1 8 4.57e-01 1.52e-01 6.87e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 4.19e-02 -1.52e-01 1.71e-01
RHOT1 GTPase cycle 5 5.57e-01 1.52e-01 7.48e-01
Glycosphingolipid catabolism 31 1.44e-01 -1.52e-01 3.59e-01
G alpha (i) signalling events 196 2.62e-04 1.51e-01 4.07e-03
Signaling by FGFR4 in disease 11 3.85e-01 -1.51e-01 6.27e-01
MAP2K and MAPK activation 36 1.17e-01 1.51e-01 3.20e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 9.50e-02 -1.51e-01 2.94e-01
Sialic acid metabolism 27 1.76e-01 1.50e-01 4.04e-01
Hh mutants abrogate ligand secretion 43 8.88e-02 -1.50e-01 2.81e-01
Retrograde neurotrophin signalling 12 3.68e-01 1.50e-01 6.15e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 2.05e-01 1.49e-01 4.43e-01
Signaling by Activin 13 3.52e-01 -1.49e-01 5.96e-01
CLEC7A (Dectin-1) signaling 85 1.77e-02 -1.49e-01 9.99e-02
RUNX1 regulates transcription of genes involved in BCR signaling 6 5.28e-01 1.49e-01 7.30e-01
G1/S-Specific Transcription 29 1.66e-01 1.49e-01 3.90e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 90 1.51e-02 -1.48e-01 8.98e-02
Amplification of signal from the kinetochores 90 1.51e-02 -1.48e-01 8.98e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 4.42e-01 1.48e-01 6.73e-01
WNT5A-dependent internalization of FZD4 13 3.56e-01 1.48e-01 6.01e-01
Signaling by FGFR in disease 52 6.52e-02 -1.48e-01 2.28e-01
Plasma lipoprotein clearance 33 1.42e-01 1.48e-01 3.56e-01
Glycerophospholipid catabolism 6 5.31e-01 1.48e-01 7.31e-01
DNA Repair 288 1.64e-05 -1.48e-01 3.63e-04
Nonhomologous End-Joining (NHEJ) 40 1.08e-01 -1.47e-01 3.14e-01
Interleukin receptor SHC signaling 23 2.23e-01 1.47e-01 4.62e-01
Golgi Associated Vesicle Biogenesis 55 6.05e-02 -1.46e-01 2.15e-01
Degradation of GLI1 by the proteasome 46 8.62e-02 -1.46e-01 2.76e-01
Sema3A PAK dependent Axon repulsion 15 3.27e-01 1.46e-01 5.83e-01
Synthesis of pyrophosphates in the cytosol 8 4.75e-01 -1.46e-01 7.00e-01
EGFR downregulation 26 1.98e-01 1.46e-01 4.34e-01
Ubiquitin-dependent degradation of Cyclin D 39 1.16e-01 -1.45e-01 3.20e-01
Peroxisomal lipid metabolism 27 1.91e-01 -1.45e-01 4.26e-01
ADORA2B mediated anti-inflammatory cytokines production 35 1.37e-01 1.45e-01 3.50e-01
Platelet sensitization by LDL 16 3.15e-01 1.45e-01 5.70e-01
Neurotransmitter release cycle 38 1.22e-01 1.45e-01 3.26e-01
Synthesis of Dolichyl-phosphate 6 5.39e-01 1.45e-01 7.35e-01
Rap1 signalling 14 3.49e-01 1.45e-01 5.94e-01
Activation of gene expression by SREBF (SREBP) 42 1.05e-01 1.45e-01 3.11e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 2.94e-02 -1.44e-01 1.37e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 5.09e-01 1.44e-01 7.22e-01
Triglyceride metabolism 24 2.22e-01 1.44e-01 4.62e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 5.09e-01 -1.44e-01 7.22e-01
Mitochondrial tRNA aminoacylation 21 2.54e-01 -1.44e-01 5.02e-01
RUNX1 regulates expression of components of tight junctions 5 5.77e-01 1.44e-01 7.64e-01
Incretin synthesis, secretion, and inactivation 14 3.51e-01 -1.44e-01 5.96e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 3.51e-01 -1.44e-01 5.96e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 1.97e-01 -1.44e-01 4.31e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 7.43e-02 -1.43e-01 2.52e-01
TRIF-mediated programmed cell death 9 4.58e-01 -1.43e-01 6.87e-01
PKA-mediated phosphorylation of CREB 17 3.08e-01 1.43e-01 5.61e-01
Stimuli-sensing channels 78 2.92e-02 1.43e-01 1.36e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.55e-01 -1.43e-01 6.00e-01
Interleukin-2 family signaling 38 1.28e-01 1.43e-01 3.36e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.85e-01 -1.42e-01 4.17e-01
mTORC1-mediated signalling 24 2.28e-01 -1.42e-01 4.69e-01
SARS-CoV-1 activates/modulates innate immune responses 40 1.21e-01 -1.42e-01 3.25e-01
Gene Silencing by RNA 87 2.24e-02 -1.42e-01 1.15e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 5.59e-02 -1.42e-01 2.06e-01
Maturation of nucleoprotein 9694631 15 3.43e-01 -1.41e-01 5.92e-01
ECM proteoglycans 45 1.01e-01 1.41e-01 3.03e-01
Synthesis of DNA 108 1.12e-02 -1.41e-01 7.42e-02
PI-3K cascade:FGFR4 11 4.18e-01 -1.41e-01 6.60e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.15e-01 -1.40e-01 3.20e-01
Phosphate bond hydrolysis by NTPDase proteins 6 5.52e-01 -1.40e-01 7.44e-01
Ribavirin ADME 11 4.21e-01 1.40e-01 6.63e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.43e-01 -1.40e-01 6.74e-01
NR1H2 and NR1H3-mediated signaling 38 1.35e-01 1.40e-01 3.47e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 2.67e-01 1.40e-01 5.14e-01
Neurodegenerative Diseases 21 2.67e-01 1.40e-01 5.14e-01
RND1 GTPase cycle 36 1.46e-01 -1.40e-01 3.62e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 36 1.47e-01 -1.40e-01 3.62e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 78 3.30e-02 1.40e-01 1.46e-01
Regulation of TP53 Activity through Acetylation 29 1.94e-01 1.39e-01 4.28e-01
Maturation of spike protein 9694548 35 1.54e-01 1.39e-01 3.74e-01
IkBA variant leads to EDA-ID 7 5.25e-01 1.39e-01 7.29e-01
Downstream signal transduction 27 2.13e-01 1.38e-01 4.52e-01
Regulation of KIT signaling 15 3.54e-01 1.38e-01 5.98e-01
Retrograde transport at the Trans-Golgi-Network 49 9.42e-02 -1.38e-01 2.93e-01
Cell junction organization 77 3.62e-02 1.38e-01 1.53e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 6.25e-02 -1.38e-01 2.21e-01
Packaging Of Telomere Ends 18 3.13e-01 1.37e-01 5.67e-01
Telomere Extension By Telomerase 23 2.54e-01 1.37e-01 5.02e-01
Pre-NOTCH Transcription and Translation 47 1.04e-01 1.37e-01 3.09e-01
Transcriptional regulation by small RNAs 61 6.40e-02 -1.37e-01 2.25e-01
Formation of WDR5-containing histone-modifying complexes 42 1.24e-01 -1.37e-01 3.29e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.39e-01 -1.37e-01 3.51e-01
p53-Independent DNA Damage Response 39 1.39e-01 -1.37e-01 3.51e-01
p53-Independent G1/S DNA damage checkpoint 39 1.39e-01 -1.37e-01 3.51e-01
Xenobiotics 9 4.78e-01 -1.37e-01 7.01e-01
Nucleotide salvage 21 2.79e-01 1.36e-01 5.28e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 3.79e-01 -1.36e-01 6.22e-01
FGFR2 alternative splicing 25 2.40e-01 -1.36e-01 4.85e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 1.08e-01 1.36e-01 3.14e-01
Role of second messengers in netrin-1 signaling 6 5.66e-01 1.35e-01 7.56e-01
Sensory Perception 188 1.38e-03 1.35e-01 1.53e-02
Senescence-Associated Secretory Phenotype (SASP) 64 6.13e-02 1.35e-01 2.17e-01
Regulation of RUNX3 expression and activity 45 1.17e-01 -1.35e-01 3.20e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 7.81e-02 1.35e-01 2.59e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.39e-01 -1.35e-01 6.73e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 4.19e-01 -1.35e-01 6.60e-01
Signaling by FGFR2 IIIa TM 18 3.23e-01 -1.35e-01 5.77e-01
Metabolism of amino acids and derivatives 304 5.58e-05 -1.34e-01 1.09e-03
Interleukin-20 family signaling 17 3.38e-01 1.34e-01 5.90e-01
Cardiogenesis 13 4.02e-01 1.34e-01 6.46e-01
Cellular responses to mechanical stimuli 83 3.48e-02 1.34e-01 1.50e-01
Response of endothelial cells to shear stress 83 3.48e-02 1.34e-01 1.50e-01
Protein ubiquitination 71 5.10e-02 -1.34e-01 1.96e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 3.69e-01 -1.34e-01 6.15e-01
RNA Polymerase II Pre-transcription Events 77 4.24e-02 -1.34e-01 1.73e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 2.90e-01 1.33e-01 5.40e-01
Interleukin-35 Signalling 12 4.24e-01 -1.33e-01 6.63e-01
Signaling by PDGF 48 1.10e-01 1.33e-01 3.15e-01
Vitamin B5 (pantothenate) metabolism 20 3.02e-01 1.33e-01 5.56e-01
Abacavir ADME 5 6.07e-01 1.33e-01 7.82e-01
Autophagy 142 6.28e-03 -1.33e-01 4.92e-02
Ca-dependent events 29 2.16e-01 1.33e-01 4.56e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 3.74e-01 -1.33e-01 6.17e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 3.74e-01 -1.33e-01 6.17e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 3.74e-01 -1.33e-01 6.17e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 3.74e-01 -1.33e-01 6.17e-01
Signaling by CTNNB1 phospho-site mutants 15 3.74e-01 -1.33e-01 6.17e-01
Signaling by GSK3beta mutants 15 3.74e-01 -1.33e-01 6.17e-01
Regulation of ornithine decarboxylase (ODC) 38 1.57e-01 -1.33e-01 3.79e-01
Activation of NOXA and translocation to mitochondria 5 6.08e-01 1.32e-01 7.83e-01
Removal of the Flap Intermediate from the C-strand 17 3.45e-01 -1.32e-01 5.92e-01
STING mediated induction of host immune responses 15 3.76e-01 -1.32e-01 6.19e-01
FGFR2 mutant receptor activation 23 2.74e-01 -1.32e-01 5.21e-01
Triglyceride catabolism 15 3.77e-01 1.32e-01 6.19e-01
MAPK6/MAPK4 signaling 69 5.87e-02 -1.32e-01 2.11e-01
LGI-ADAM interactions 9 4.94e-01 1.32e-01 7.13e-01
SHC1 events in ERBB4 signaling 10 4.71e-01 -1.32e-01 6.99e-01
Processive synthesis on the C-strand of the telomere 19 3.21e-01 -1.31e-01 5.75e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.13e-01 -1.31e-01 4.52e-01
Early SARS-CoV-2 Infection Events 30 2.14e-01 -1.31e-01 4.54e-01
SARS-CoV-2 Infection 263 2.59e-04 -1.31e-01 4.04e-03
ALK mutants bind TKIs 11 4.53e-01 -1.31e-01 6.83e-01
DNA Replication Pre-Initiation 103 2.21e-02 -1.31e-01 1.14e-01
Proton-coupled monocarboxylate transport 6 5.80e-01 1.31e-01 7.65e-01
NOD1/2 Signaling Pathway 36 1.76e-01 -1.30e-01 4.04e-01
Physiological factors 9 4.99e-01 1.30e-01 7.16e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 5.82e-01 1.30e-01 7.65e-01
Neutrophil degranulation 456 2.11e-06 1.30e-01 5.33e-05
Tie2 Signaling 16 3.71e-01 -1.29e-01 6.16e-01
Pyruvate metabolism 44 1.38e-01 -1.29e-01 3.51e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 2.64e-01 -1.29e-01 5.12e-01
Switching of origins to a post-replicative state 79 4.74e-02 -1.29e-01 1.87e-01
Pyrimidine catabolism 9 5.03e-01 1.29e-01 7.18e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 3.57e-01 1.29e-01 6.03e-01
Disorders of Developmental Biology 12 4.39e-01 1.29e-01 6.73e-01
Disorders of Nervous System Development 12 4.39e-01 1.29e-01 6.73e-01
Loss of function of MECP2 in Rett syndrome 12 4.39e-01 1.29e-01 6.73e-01
Pervasive developmental disorders 12 4.39e-01 1.29e-01 6.73e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 2.65e-01 1.29e-01 5.14e-01
RUNX2 regulates osteoblast differentiation 16 3.73e-01 1.29e-01 6.17e-01
Signaling by the B Cell Receptor (BCR) 150 6.65e-03 1.28e-01 5.07e-02
Scavenging by Class A Receptors 10 4.82e-01 1.28e-01 7.04e-01
Interleukin-1 processing 8 5.30e-01 1.28e-01 7.31e-01
Separation of Sister Chromatids 167 4.32e-03 -1.28e-01 3.65e-02
DAP12 interactions 39 1.67e-01 -1.28e-01 3.90e-01
Regulation of Expression and Function of Type II Classical Cadherins 23 2.90e-01 1.28e-01 5.40e-01
Regulation of Homotypic Cell-Cell Adhesion 23 2.90e-01 1.28e-01 5.40e-01
PI3K/AKT Signaling in Cancer 83 4.51e-02 1.27e-01 1.81e-01
Formation of definitive endoderm 8 5.33e-01 -1.27e-01 7.32e-01
GRB2 events in EGFR signaling 10 4.87e-01 1.27e-01 7.09e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.93e-01 1.27e-01 5.42e-01
Interleukin-27 signaling 11 4.68e-01 -1.26e-01 6.98e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 4.31e-01 -1.26e-01 6.67e-01
CD209 (DC-SIGN) signaling 20 3.29e-01 -1.26e-01 5.84e-01
FCERI mediated NF-kB activation 129 1.34e-02 1.26e-01 8.30e-02
Antigen processing: Ubiquitination & Proteasome degradation 275 3.25e-04 -1.26e-01 4.99e-03
G2/M DNA damage checkpoint 66 7.69e-02 -1.26e-01 2.56e-01
Activation of the pre-replicative complex 32 2.19e-01 -1.26e-01 4.59e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.08e-01 -1.25e-01 5.61e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 4.72e-01 1.25e-01 6.99e-01
DNA Double-Strand Break Repair 137 1.14e-02 -1.25e-01 7.47e-02
Condensation of Prophase Chromosomes 27 2.60e-01 1.25e-01 5.08e-01
Cellular response to hypoxia 59 9.69e-02 -1.25e-01 2.97e-01
G-protein activation 19 3.46e-01 1.25e-01 5.92e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 5.96e-01 -1.25e-01 7.76e-01
Signalling to ERKs 32 2.22e-01 1.25e-01 4.62e-01
TRP channels 21 3.23e-01 1.25e-01 5.77e-01
Visual phototransduction 58 1.02e-01 1.24e-01 3.04e-01
TBC/RABGAPs 45 1.49e-01 1.24e-01 3.66e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 4.25e-02 1.24e-01 1.73e-01
Cell Cycle Checkpoints 245 8.56e-04 -1.24e-01 1.09e-02
Defective Intrinsic Pathway for Apoptosis 24 2.94e-01 1.24e-01 5.45e-01
PI-3K cascade:FGFR1 13 4.40e-01 -1.24e-01 6.73e-01
Platelet activation, signaling and aggregation 219 1.64e-03 1.23e-01 1.73e-02
Notch-HLH transcription pathway 28 2.59e-01 1.23e-01 5.07e-01
Class I MHC mediated antigen processing & presentation 343 8.84e-05 -1.23e-01 1.54e-03
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.25e-01 1.23e-01 6.64e-01
Lysine catabolism 10 5.00e-01 1.23e-01 7.17e-01
Generation of second messenger molecules 38 1.89e-01 -1.23e-01 4.24e-01
RNA Polymerase I Transcription Termination 30 2.44e-01 -1.23e-01 4.88e-01
Meiotic recombination 36 2.02e-01 -1.23e-01 4.39e-01
PIWI-interacting RNA (piRNA) biogenesis 23 3.07e-01 -1.23e-01 5.61e-01
Long-term potentiation 14 4.26e-01 -1.23e-01 6.64e-01
PECAM1 interactions 12 4.61e-01 1.23e-01 6.90e-01
Glycogen breakdown (glycogenolysis) 12 4.62e-01 1.23e-01 6.91e-01
FLT3 Signaling 38 1.91e-01 1.23e-01 4.26e-01
Glyoxylate metabolism and glycine degradation 13 4.44e-01 1.23e-01 6.75e-01
Pre-NOTCH Expression and Processing 63 9.30e-02 1.22e-01 2.91e-01
Interferon Signaling 237 1.24e-03 -1.22e-01 1.42e-02
ATF6 (ATF6-alpha) activates chaperones 12 4.65e-01 -1.22e-01 6.95e-01
Mitotic Anaphase 210 2.39e-03 -1.22e-01 2.30e-02
PLC beta mediated events 39 1.90e-01 1.21e-01 4.25e-01
Activation of ATR in response to replication stress 37 2.02e-01 -1.21e-01 4.39e-01
Nitric oxide stimulates guanylate cyclase 15 4.17e-01 1.21e-01 6.60e-01
Mitotic Metaphase and Anaphase 211 2.47e-03 -1.21e-01 2.38e-02
Passive transport by Aquaporins 6 6.08e-01 1.21e-01 7.83e-01
Insulin receptor recycling 24 3.06e-01 1.21e-01 5.61e-01
Phenylalanine and tyrosine metabolism 9 5.31e-01 -1.21e-01 7.31e-01
Post-transcriptional silencing by small RNAs 7 5.80e-01 -1.21e-01 7.65e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.04e-01 -1.21e-01 3.09e-01
Sensory processing of sound by outer hair cells of the cochlea 40 1.89e-01 1.20e-01 4.24e-01
Activation of RAC1 11 4.91e-01 -1.20e-01 7.10e-01
Neurotoxicity of clostridium toxins 9 5.35e-01 1.20e-01 7.34e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.01e-01 -1.20e-01 3.03e-01
Metabolism of folate and pterines 16 4.09e-01 1.19e-01 6.52e-01
Drug ADME 55 1.26e-01 1.19e-01 3.33e-01
Negative regulation of the PI3K/AKT network 91 4.99e-02 1.19e-01 1.93e-01
Hedgehog ligand biogenesis 47 1.59e-01 -1.19e-01 3.80e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 3.04e-01 1.19e-01 5.58e-01
Signaling by PDGFRA extracellular domain mutants 12 4.77e-01 -1.19e-01 7.00e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 4.77e-01 -1.19e-01 7.00e-01
Processing of DNA double-strand break ends 69 8.84e-02 -1.19e-01 2.81e-01
CaM pathway 27 2.87e-01 1.18e-01 5.35e-01
Calmodulin induced events 27 2.87e-01 1.18e-01 5.35e-01
Nef Mediated CD4 Down-regulation 9 5.39e-01 1.18e-01 7.35e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.19e-01 1.18e-01 4.59e-01
Apoptotic execution phase 46 1.66e-01 -1.18e-01 3.89e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 9.73e-02 -1.18e-01 2.97e-01
Cellular response to heat stress 92 5.16e-02 -1.17e-01 1.97e-01
S Phase 150 1.31e-02 -1.17e-01 8.17e-02
Mitochondrial Uncoupling 6 6.19e-01 -1.17e-01 7.93e-01
ROS and RNS production in phagocytes 30 2.67e-01 1.17e-01 5.14e-01
Defensins 8 5.67e-01 1.17e-01 7.58e-01
Smooth Muscle Contraction 34 2.39e-01 1.17e-01 4.84e-01
Signaling by SCF-KIT 40 2.02e-01 1.17e-01 4.39e-01
C-type lectin receptors (CLRs) 116 3.02e-02 -1.16e-01 1.39e-01
G beta:gamma signalling through PI3Kgamma 22 3.45e-01 1.16e-01 5.92e-01
SHC1 events in EGFR signaling 11 5.04e-01 1.16e-01 7.19e-01
Regulation of APC/C activators between G1/S and early anaphase 68 9.76e-02 -1.16e-01 2.98e-01
RNA Polymerase III Chain Elongation 18 3.94e-01 -1.16e-01 6.37e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 2.57e-01 1.16e-01 5.04e-01
Cilium Assembly 187 6.39e-03 -1.16e-01 4.97e-02
Specification of primordial germ cells 6 6.26e-01 1.15e-01 7.99e-01
Downregulation of TGF-beta receptor signaling 26 3.11e-01 -1.15e-01 5.63e-01
CDK-mediated phosphorylation and removal of Cdc6 60 1.24e-01 -1.15e-01 3.29e-01
Selective autophagy 77 8.19e-02 -1.15e-01 2.67e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 6.01e-01 -1.14e-01 7.80e-01
CDC42 GTPase cycle 139 2.01e-02 1.14e-01 1.10e-01
Glycogen synthesis 11 5.12e-01 -1.14e-01 7.22e-01
Collagen chain trimerization 26 3.14e-01 1.14e-01 5.69e-01
Transcriptional regulation of white adipocyte differentiation 77 8.43e-02 1.14e-01 2.71e-01
Dectin-2 family 18 4.04e-01 1.14e-01 6.47e-01
Cholesterol biosynthesis 26 3.16e-01 1.14e-01 5.71e-01
MTOR signalling 39 2.20e-01 -1.14e-01 4.60e-01
Release of apoptotic factors from the mitochondria 6 6.30e-01 -1.13e-01 8.01e-01
Signaling by WNT in cancer 30 2.83e-01 1.13e-01 5.31e-01
Regulation of TLR by endogenous ligand 15 4.48e-01 -1.13e-01 6.77e-01
DNA Replication 128 2.76e-02 -1.13e-01 1.30e-01
TRAF3-dependent IRF activation pathway 13 4.82e-01 1.13e-01 7.04e-01
HDACs deacetylate histones 45 1.92e-01 1.12e-01 4.27e-01
Assembly of the pre-replicative complex 87 7.03e-02 -1.12e-01 2.42e-01
STAT3 nuclear events downstream of ALK signaling 11 5.20e-01 1.12e-01 7.27e-01
GABA synthesis, release, reuptake and degradation 12 5.02e-01 1.12e-01 7.17e-01
Histidine catabolism 7 6.08e-01 1.12e-01 7.83e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.85e-01 1.12e-01 7.07e-01
Ion homeostasis 40 2.22e-01 1.12e-01 4.62e-01
Synthesis of IP3 and IP4 in the cytosol 22 3.66e-01 1.11e-01 6.12e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 3.89e-01 1.11e-01 6.32e-01
Organelle biogenesis and maintenance 278 1.42e-03 -1.11e-01 1.54e-02
Transmission across Chemical Synapses 179 1.06e-02 1.11e-01 7.16e-02
APC truncation mutants have impaired AXIN binding 14 4.73e-01 -1.11e-01 6.99e-01
AXIN missense mutants destabilize the destruction complex 14 4.73e-01 -1.11e-01 6.99e-01
Signaling by AMER1 mutants 14 4.73e-01 -1.11e-01 6.99e-01
Signaling by APC mutants 14 4.73e-01 -1.11e-01 6.99e-01
Signaling by AXIN mutants 14 4.73e-01 -1.11e-01 6.99e-01
Truncations of AMER1 destabilize the destruction complex 14 4.73e-01 -1.11e-01 6.99e-01
Eicosanoid ligand-binding receptors 13 4.90e-01 1.11e-01 7.10e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.45e-01 -1.10e-01 7.41e-01
Signaling by KIT in disease 20 3.94e-01 -1.10e-01 6.37e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 3.94e-01 -1.10e-01 6.37e-01
TRAIL signaling 8 5.90e-01 -1.10e-01 7.72e-01
Activation of C3 and C5 7 6.15e-01 1.10e-01 7.89e-01
trans-Golgi Network Vesicle Budding 69 1.15e-01 -1.10e-01 3.20e-01
Dissolution of Fibrin Clot 12 5.12e-01 1.09e-01 7.22e-01
SLC-mediated transmembrane transport 171 1.38e-02 1.09e-01 8.48e-02
Regulation of PTEN stability and activity 55 1.65e-01 -1.08e-01 3.88e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 5.77e-01 -1.07e-01 7.64e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 2.18e-01 1.07e-01 4.58e-01
RHOA GTPase cycle 138 2.96e-02 1.07e-01 1.37e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.28e-01 1.07e-01 5.83e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 2.01e-01 1.07e-01 4.39e-01
Regulation of RAS by GAPs 55 1.71e-01 -1.07e-01 3.96e-01
APC/C-mediated degradation of cell cycle proteins 75 1.11e-01 -1.07e-01 3.15e-01
Regulation of mitotic cell cycle 75 1.11e-01 -1.07e-01 3.15e-01
EPHB-mediated forward signaling 38 2.56e-01 -1.07e-01 5.04e-01
Sensory processing of sound 57 1.65e-01 1.06e-01 3.89e-01
G-protein mediated events 43 2.28e-01 1.06e-01 4.69e-01
Chromosome Maintenance 102 6.43e-02 -1.06e-01 2.25e-01
Transcriptional Regulation by MECP2 47 2.09e-01 1.06e-01 4.48e-01
Transcriptional regulation by RUNX1 170 1.74e-02 1.06e-01 9.88e-02
CHL1 interactions 8 6.05e-01 1.06e-01 7.82e-01
Nicotinate metabolism 26 3.51e-01 -1.06e-01 5.96e-01
TGFBR3 regulates TGF-beta signaling 8 6.06e-01 -1.05e-01 7.82e-01
Metalloprotease DUBs 20 4.15e-01 -1.05e-01 6.58e-01
RHO GTPases activate CIT 18 4.41e-01 1.05e-01 6.73e-01
MECP2 regulates neuronal receptors and channels 13 5.13e-01 1.05e-01 7.22e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 9.67e-02 1.05e-01 2.97e-01
Extension of Telomeres 51 1.96e-01 -1.05e-01 4.31e-01
Regulation of localization of FOXO transcription factors 11 5.48e-01 1.04e-01 7.43e-01
Interleukin-21 signaling 9 5.87e-01 1.04e-01 7.69e-01
Antigen processing-Cross presentation 88 9.04e-02 -1.04e-01 2.85e-01
Interleukin-15 signaling 14 5.00e-01 1.04e-01 7.17e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.50e-01 -1.04e-01 3.66e-01
Metabolism of proteins 1761 4.37e-13 -1.04e-01 6.99e-11
Orc1 removal from chromatin 58 1.72e-01 -1.04e-01 3.98e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 4.47e-01 1.03e-01 6.77e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.52e-01 1.03e-01 7.44e-01
Signaling by ERBB2 KD Mutants 20 4.23e-01 -1.03e-01 6.63e-01
Ion channel transport 136 3.74e-02 1.03e-01 1.57e-01
p130Cas linkage to MAPK signaling for integrins 11 5.53e-01 1.03e-01 7.44e-01
PI5P Regulates TP53 Acetylation 8 6.14e-01 1.03e-01 7.88e-01
Regulation of FZD by ubiquitination 15 4.90e-01 1.03e-01 7.10e-01
p53-Dependent G1 DNA Damage Response 52 2.01e-01 -1.02e-01 4.39e-01
p53-Dependent G1/S DNA damage checkpoint 52 2.01e-01 -1.02e-01 4.39e-01
Adipogenesis 95 8.47e-02 1.02e-01 2.72e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 4.18e-01 1.02e-01 6.60e-01
Budding and maturation of HIV virion 26 3.68e-01 -1.02e-01 6.15e-01
Formation of axial mesoderm 6 6.66e-01 1.02e-01 8.27e-01
Ub-specific processing proteases 153 3.01e-02 -1.02e-01 1.38e-01
RIPK1-mediated regulated necrosis 31 3.31e-01 -1.01e-01 5.87e-01
Regulation of necroptotic cell death 31 3.31e-01 -1.01e-01 5.87e-01
Activation of Ca-permeable Kainate Receptor 8 6.23e-01 1.00e-01 7.96e-01
Ionotropic activity of kainate receptors 8 6.23e-01 1.00e-01 7.96e-01
FGFR4 ligand binding and activation 5 6.98e-01 1.00e-01 8.49e-01
Mitochondrial biogenesis 91 9.90e-02 -1.00e-01 3.00e-01
Cell-Cell communication 108 7.25e-02 1.00e-01 2.49e-01
Regulation of CDH11 mRNA translation by microRNAs 8 6.27e-01 -9.91e-02 8.00e-01
Regulation of NPAS4 mRNA translation 8 6.27e-01 -9.91e-02 8.00e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 2.56e-01 -9.91e-02 5.03e-01
NrCAM interactions 6 6.75e-01 -9.89e-02 8.33e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.54e-01 9.87e-02 7.44e-01
Phase 2 - plateau phase 12 5.54e-01 9.87e-02 7.44e-01
TCF dependent signaling in response to WNT 151 3.69e-02 9.84e-02 1.55e-01
Cytosolic sulfonation of small molecules 18 4.71e-01 9.82e-02 6.99e-01
Paracetamol ADME 19 4.59e-01 9.82e-02 6.88e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 5.73e-01 9.81e-02 7.61e-01
Signaling by NODAL 15 5.13e-01 -9.76e-02 7.22e-01
Signaling by ERBB2 in Cancer 21 4.40e-01 -9.74e-02 6.73e-01
HATs acetylate histones 92 1.07e-01 -9.73e-02 3.13e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.82e-01 -9.72e-02 6.23e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.82e-01 -9.72e-02 6.23e-01
Mitotic Prophase 96 1.00e-01 -9.71e-02 3.01e-01
NPAS4 regulates expression of target genes 16 5.01e-01 9.71e-02 7.17e-01
Homology Directed Repair 110 7.85e-02 -9.71e-02 2.59e-01
Sensory perception of taste 23 4.23e-01 9.66e-02 6.63e-01
Neurotransmitter receptors and postsynaptic signal transmission 132 5.65e-02 9.61e-02 2.07e-01
Metabolism of polyamines 46 2.60e-01 -9.60e-02 5.08e-01
Formation of the Early Elongation Complex 33 3.41e-01 -9.57e-02 5.92e-01
Formation of the HIV-1 Early Elongation Complex 33 3.41e-01 -9.57e-02 5.92e-01
PD-1 signaling 28 3.81e-01 -9.56e-02 6.23e-01
Signaling by BMP 23 4.28e-01 -9.55e-02 6.66e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 3.66e-01 9.54e-02 6.12e-01
Meiosis 66 1.80e-01 -9.54e-02 4.10e-01
Cargo recognition for clathrin-mediated endocytosis 88 1.23e-01 -9.52e-02 3.27e-01
Degradation of DVL 43 2.80e-01 -9.52e-02 5.29e-01
Activation of kainate receptors upon glutamate binding 25 4.10e-01 9.51e-02 6.53e-01
p75NTR recruits signalling complexes 12 5.69e-01 -9.50e-02 7.59e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.04e-01 -9.47e-02 7.82e-01
Respiratory syncytial virus (RSV) attachment and entry 17 5.00e-01 9.46e-02 7.17e-01
TP53 Regulates Metabolic Genes 77 1.53e-01 -9.41e-02 3.74e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 5.15e-01 -9.40e-02 7.25e-01
Synthesis of Ketone Bodies 6 6.90e-01 9.39e-02 8.42e-01
Signaling by EGFR 47 2.66e-01 9.38e-02 5.14e-01
Purine catabolism 16 5.16e-01 -9.37e-02 7.26e-01
Signaling by NOTCH1 66 1.88e-01 9.37e-02 4.22e-01
Regulation of CDH11 Expression and Function 22 4.48e-01 9.35e-02 6.77e-01
Miscellaneous transport and binding events 20 4.69e-01 9.35e-02 6.99e-01
M Phase 345 2.86e-03 -9.35e-02 2.64e-02
ABC-family proteins mediated transport 81 1.46e-01 -9.34e-02 3.61e-01
Sema4D mediated inhibition of cell attachment and migration 7 6.69e-01 9.32e-02 8.28e-01
Chaperonin-mediated protein folding 77 1.58e-01 9.31e-02 3.79e-01
G beta:gamma signalling through PLC beta 17 5.09e-01 9.26e-02 7.22e-01
Presynaptic function of Kainate receptors 17 5.09e-01 9.26e-02 7.22e-01
Viral Infection Pathways 770 1.25e-05 -9.26e-02 2.86e-04
Interconversion of nucleotide di- and triphosphates 27 4.07e-01 -9.23e-02 6.50e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.45e-01 -9.22e-02 5.92e-01
Signaling by Interleukins 387 1.86e-03 9.22e-02 1.93e-02
Signaling by Erythropoietin 24 4.35e-01 9.21e-02 6.71e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 5.81e-01 -9.20e-02 7.65e-01
RHOQ GTPase cycle 54 2.44e-01 9.16e-02 4.89e-01
FGFR3 ligand binding and activation 5 7.23e-01 9.15e-02 8.61e-01
FGFR3c ligand binding and activation 5 7.23e-01 9.15e-02 8.61e-01
Signaling by NOTCH4 68 1.93e-01 -9.14e-02 4.27e-01
Reactions specific to the complex N-glycan synthesis pathway 7 6.76e-01 9.14e-02 8.33e-01
MAPK1 (ERK2) activation 8 6.55e-01 -9.13e-02 8.17e-01
Ephrin signaling 17 5.15e-01 -9.12e-02 7.25e-01
Aggrephagy 34 3.58e-01 9.11e-02 6.03e-01
Interferon gamma signaling 87 1.42e-01 -9.10e-02 3.57e-01
Signaling by RAF1 mutants 36 3.45e-01 9.09e-02 5.92e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 4.41e-01 -9.08e-02 6.73e-01
MAP kinase activation 63 2.15e-01 -9.03e-02 4.55e-01
Erythropoietin activates RAS 13 5.73e-01 9.02e-02 7.61e-01
DAG and IP3 signaling 33 3.74e-01 8.95e-02 6.17e-01
tRNA Aminoacylation 42 3.17e-01 -8.93e-02 5.71e-01
Cytosolic iron-sulfur cluster assembly 13 5.77e-01 8.93e-02 7.64e-01
Zinc transporters 12 5.93e-01 8.92e-02 7.74e-01
Platelet degranulation 104 1.17e-01 8.91e-02 3.20e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.18e-01 -8.90e-02 5.72e-01
HIV Transcription Elongation 42 3.18e-01 -8.90e-02 5.72e-01
Tat-mediated elongation of the HIV-1 transcript 42 3.18e-01 -8.90e-02 5.72e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 1.18e-01 -8.87e-02 3.22e-01
tRNA modification in the mitochondrion 9 6.45e-01 -8.87e-02 8.10e-01
Biosynthesis of maresins 5 7.31e-01 8.86e-02 8.67e-01
G1/S DNA Damage Checkpoints 54 2.61e-01 -8.84e-02 5.10e-01
Anchoring of the basal body to the plasma membrane 97 1.33e-01 -8.83e-02 3.44e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 5.18e-01 -8.80e-02 7.26e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 5.18e-01 -8.80e-02 7.26e-01
Malate-aspartate shuttle 8 6.68e-01 -8.76e-02 8.28e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 5.70e-01 -8.76e-02 7.59e-01
G2/M Checkpoints 126 8.98e-02 -8.75e-02 2.83e-01
Iron uptake and transport 52 2.75e-01 -8.75e-02 5.23e-01
Sensory processing of sound by inner hair cells of the cochlea 54 2.66e-01 8.74e-02 5.14e-01
Resolution of Abasic Sites (AP sites) 38 3.51e-01 -8.74e-02 5.96e-01
Phospholipase C-mediated cascade; FGFR2 8 6.69e-01 8.73e-02 8.28e-01
Presynaptic depolarization and calcium channel opening 8 6.71e-01 -8.69e-02 8.28e-01
Signaling by NTRK2 (TRKB) 20 5.01e-01 -8.69e-02 7.17e-01
RNA Polymerase III Transcription Termination 22 4.81e-01 -8.68e-02 7.03e-01
MAPK3 (ERK1) activation 9 6.52e-01 -8.67e-02 8.16e-01
DNA Damage Reversal 8 6.71e-01 -8.67e-02 8.28e-01
Assembly of the ORC complex at the origin of replication 23 4.73e-01 -8.64e-02 6.99e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 5.37e-01 8.64e-02 7.34e-01
Mitotic Prometaphase 192 3.92e-02 -8.63e-02 1.62e-01
Sodium/Calcium exchangers 9 6.55e-01 8.60e-02 8.17e-01
Signal Transduction 2034 1.82e-10 8.58e-02 1.30e-08
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 4.02e-01 8.56e-02 6.46e-01
RHOV GTPase cycle 36 3.76e-01 -8.53e-02 6.19e-01
Regulation of NPAS4 gene expression 11 6.25e-01 -8.52e-02 7.98e-01
Signaling by ALK fusions and activated point mutants 89 1.65e-01 8.52e-02 3.88e-01
Signaling by ALK in cancer 89 1.65e-01 8.52e-02 3.88e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 1.77e-01 8.48e-02 4.04e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 1.77e-01 8.48e-02 4.04e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 1.77e-01 8.48e-02 4.04e-01
Activation of RAS in B cells 5 7.43e-01 8.45e-02 8.74e-01
Mitochondrial unfolded protein response (UPRmt) 17 5.46e-01 8.45e-02 7.42e-01
Beta-oxidation of very long chain fatty acids 11 6.28e-01 8.43e-02 8.00e-01
RNA Polymerase III Transcription Initiation 36 3.81e-01 -8.43e-02 6.23e-01
Downstream signaling of activated FGFR3 17 5.48e-01 -8.42e-02 7.43e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.80e-01 8.41e-02 5.29e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 7.01e-01 8.38e-02 8.51e-01
Glucagon-type ligand receptors 19 5.28e-01 8.37e-02 7.30e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 4.87e-01 8.37e-02 7.09e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 4.87e-01 8.37e-02 7.09e-01
Regulation of TP53 Activity 151 7.67e-02 -8.35e-02 2.56e-01
Nucleotide-like (purinergic) receptors 14 5.89e-01 8.34e-02 7.71e-01
Interleukin-18 signaling 6 7.24e-01 8.34e-02 8.61e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.30e-01 8.33e-02 7.31e-01
Resolution of Sister Chromatid Cohesion 115 1.23e-01 -8.32e-02 3.28e-01
Transport and synthesis of PAPS 6 7.25e-01 -8.29e-02 8.62e-01
Cytosolic tRNA aminoacylation 24 4.83e-01 -8.27e-02 7.04e-01
Receptor-type tyrosine-protein phosphatases 11 6.36e-01 8.24e-02 8.03e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 6.52e-01 8.24e-02 8.16e-01
Activation of the phototransduction cascade 8 6.87e-01 -8.22e-02 8.39e-01
Response to elevated platelet cytosolic Ca2+ 108 1.40e-01 8.21e-02 3.54e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 4.96e-01 8.20e-02 7.14e-01
Nucleotide catabolism 29 4.45e-01 -8.19e-02 6.76e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 4.80e-01 8.16e-02 7.03e-01
Uptake and function of anthrax toxins 10 6.56e-01 8.13e-02 8.18e-01
RORA activates gene expression 18 5.52e-01 8.10e-02 7.44e-01
Protein folding 83 2.02e-01 8.10e-02 4.39e-01
EGFR Transactivation by Gastrin 7 7.11e-01 8.09e-02 8.57e-01
VEGFA-VEGFR2 Pathway 93 1.78e-01 8.08e-02 4.06e-01
Signaling by NOTCH2 33 4.23e-01 8.06e-02 6.63e-01
Erythropoietin activates STAT5 6 7.33e-01 8.06e-02 8.68e-01
Signal transduction by L1 20 5.33e-01 8.05e-02 7.32e-01
Syndecan interactions 23 5.05e-01 8.03e-02 7.19e-01
DNA strand elongation 32 4.32e-01 -8.03e-02 6.69e-01
Metabolism of carbohydrates 236 3.55e-02 7.95e-02 1.51e-01
Azathioprine ADME 20 5.39e-01 7.94e-02 7.35e-01
Cell Cycle 609 8.26e-04 -7.94e-02 1.08e-02
P2Y receptors 10 6.65e-01 7.91e-02 8.26e-01
Deactivation of the beta-catenin transactivating complex 36 4.12e-01 7.90e-02 6.55e-01
Caspase activation via Death Receptors in the presence of ligand 16 5.86e-01 -7.87e-02 7.68e-01
ABC transporter disorders 59 2.96e-01 -7.87e-02 5.47e-01
EML4 and NUDC in mitotic spindle formation 106 1.62e-01 -7.86e-02 3.86e-01
Endogenous sterols 17 5.75e-01 -7.85e-02 7.62e-01
Cell-cell junction organization 56 3.10e-01 7.85e-02 5.62e-01
Signaling by Insulin receptor 63 2.82e-01 7.83e-02 5.31e-01
Regulation of innate immune responses to cytosolic DNA 14 6.12e-01 -7.82e-02 7.87e-01
Heparan sulfate/heparin (HS-GAG) metabolism 39 3.98e-01 7.82e-02 6.42e-01
SLC15A4:TASL-dependent IRF5 activation 6 7.41e-01 -7.80e-02 8.74e-01
Disorders of transmembrane transporters 134 1.19e-01 -7.80e-02 3.23e-01
Nucleotide biosynthesis 12 6.41e-01 7.78e-02 8.07e-01
SUMOylation 167 8.36e-02 -7.76e-02 2.71e-01
RIP-mediated NFkB activation via ZBP1 17 5.81e-01 7.74e-02 7.65e-01
Negative regulation of MET activity 18 5.70e-01 -7.73e-02 7.59e-01
MicroRNA (miRNA) biogenesis 24 5.12e-01 -7.73e-02 7.22e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 20 5.51e-01 7.70e-02 7.44e-01
SLC transporter disorders 75 2.49e-01 -7.70e-02 4.96e-01
Sperm Motility And Taxes 6 7.45e-01 7.67e-02 8.74e-01
Regulation of TNFR1 signaling 47 3.63e-01 7.66e-02 6.10e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 6.77e-01 -7.62e-02 8.34e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.36e-01 -7.58e-02 8.03e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 7.29e-01 7.57e-02 8.65e-01
Downstream signaling of activated FGFR2 20 5.59e-01 -7.56e-02 7.50e-01
RMTs methylate histone arginines 35 4.40e-01 7.54e-02 6.73e-01
Signaling by Receptor Tyrosine Kinases 443 6.71e-03 7.51e-02 5.07e-02
p75 NTR receptor-mediated signalling 89 2.21e-01 7.51e-02 4.61e-01
Synthesis of PE 12 6.53e-01 -7.50e-02 8.16e-01
Innate Immune System 966 8.18e-05 7.49e-02 1.47e-03
Signaling by ERBB4 45 3.85e-01 -7.48e-02 6.27e-01
Late endosomal microautophagy 30 4.78e-01 7.48e-02 7.01e-01
PI Metabolism 79 2.51e-01 -7.47e-02 4.99e-01
Arachidonate production from DAG 5 7.72e-01 7.47e-02 8.87e-01
Receptor Mediated Mitophagy 11 6.68e-01 -7.46e-02 8.28e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 4.95e-01 -7.46e-02 7.13e-01
Signaling by FGFR2 61 3.15e-01 -7.44e-02 5.69e-01
Ketone body metabolism 8 7.16e-01 7.44e-02 8.59e-01
Regulated Necrosis 55 3.41e-01 -7.42e-02 5.92e-01
Activated NTRK2 signals through RAS 6 7.54e-01 -7.39e-02 8.80e-01
Activated NTRK3 signals through RAS 6 7.54e-01 -7.39e-02 8.80e-01
Prostacyclin signalling through prostacyclin receptor 16 6.10e-01 7.36e-02 7.85e-01
Formation of RNA Pol II elongation complex 56 3.43e-01 -7.33e-02 5.92e-01
RNA Polymerase II Transcription Elongation 56 3.43e-01 -7.33e-02 5.92e-01
Signaling by VEGF 100 2.06e-01 7.33e-02 4.43e-01
Oxidative Stress Induced Senescence 77 2.67e-01 7.32e-02 5.14e-01
Transport of small molecules 548 3.41e-03 7.32e-02 3.03e-02
VLDLR internalisation and degradation 16 6.18e-01 7.21e-02 7.92e-01
Apoptosis 157 1.19e-01 -7.21e-02 3.23e-01
Nuclear events mediated by NFE2L2 81 2.64e-01 7.17e-02 5.13e-01
ZBP1(DAI) mediated induction of type I IFNs 20 5.79e-01 7.16e-02 7.65e-01
RNA Polymerase III Abortive And Retractive Initiation 40 4.34e-01 -7.15e-02 6.70e-01
RNA Polymerase III Transcription 40 4.34e-01 -7.15e-02 6.70e-01
Regulation of PTEN gene transcription 59 3.43e-01 7.14e-02 5.92e-01
RAC1 GTPase cycle 170 1.08e-01 7.14e-02 3.15e-01
Regulation of PLK1 Activity at G2/M Transition 87 2.52e-01 -7.10e-02 5.01e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 3.46e-01 7.10e-02 5.92e-01
Cellular Senescence 142 1.45e-01 7.08e-02 3.61e-01
Fc epsilon receptor (FCERI) signaling 179 1.04e-01 7.04e-02 3.10e-01
MITF-M-dependent gene expression 81 2.75e-01 7.02e-02 5.23e-01
Acyl chain remodeling of CL 5 7.86e-01 -7.00e-02 8.97e-01
Intra-Golgi traffic 43 4.29e-01 -6.97e-02 6.66e-01
Glycine degradation 7 7.50e-01 6.97e-02 8.78e-01
RNA Polymerase I Transcription Initiation 47 4.09e-01 -6.96e-02 6.52e-01
Cytosolic sensors of pathogen-associated DNA 63 3.43e-01 -6.91e-02 5.92e-01
AMPK inhibits chREBP transcriptional activation activity 6 7.70e-01 -6.89e-02 8.87e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 5.22e-01 6.87e-02 7.29e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 5.70e-01 -6.84e-02 7.59e-01
G beta:gamma signalling through BTK 15 6.47e-01 6.83e-02 8.11e-01
Diseases associated with glycosylation precursor biosynthesis 15 6.49e-01 6.78e-02 8.14e-01
Phase II - Conjugation of compounds 68 3.36e-01 -6.75e-02 5.88e-01
Inactivation of CDC42 and RAC1 7 7.58e-01 6.74e-02 8.82e-01
Evasion by RSV of host interferon responses 20 6.02e-01 -6.74e-02 7.80e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 6.90e-01 6.64e-02 8.42e-01
Post NMDA receptor activation events 60 3.74e-01 6.64e-02 6.17e-01
Programmed Cell Death 186 1.19e-01 -6.63e-02 3.23e-01
Gene expression (Transcription) 1391 4.21e-05 -6.56e-02 8.42e-04
Trafficking and processing of endosomal TLR 13 6.82e-01 -6.55e-02 8.37e-01
VEGFR2 mediated vascular permeability 26 5.63e-01 6.55e-02 7.54e-01
Transcriptional Regulation by TP53 343 3.82e-02 -6.51e-02 1.59e-01
LDL clearance 18 6.32e-01 6.51e-02 8.01e-01
Telomere Maintenance 78 3.20e-01 -6.51e-02 5.75e-01
Intraflagellar transport 47 4.40e-01 -6.50e-02 6.73e-01
Synthesis of bile acids and bile salts 25 5.74e-01 -6.49e-02 7.62e-01
Signaling by ERBB2 44 4.59e-01 -6.45e-02 6.88e-01
RSK activation 7 7.68e-01 -6.43e-02 8.87e-01
Signaling by LTK in cancer 7 7.69e-01 -6.42e-02 8.87e-01
Toll Like Receptor 9 (TLR9) Cascade 108 2.50e-01 -6.40e-02 4.99e-01
Glycosphingolipid transport 7 7.69e-01 6.40e-02 8.87e-01
Constitutive Signaling by EGFRvIII 14 6.79e-01 -6.40e-02 8.34e-01
Signaling by EGFRvIII in Cancer 14 6.79e-01 -6.40e-02 8.34e-01
Diseases of metabolism 198 1.23e-01 6.36e-02 3.27e-01
HS-GAG biosynthesis 19 6.32e-01 6.35e-02 8.01e-01
IRAK4 deficiency (TLR2/4) 15 6.70e-01 -6.35e-02 8.28e-01
Advanced glycosylation endproduct receptor signaling 12 7.04e-01 -6.33e-02 8.53e-01
FGFR1c ligand binding and activation 8 7.57e-01 6.32e-02 8.82e-01
Regulation of MITF-M-dependent genes involved in pigmentation 35 5.17e-01 6.32e-02 7.26e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.43e-01 -6.32e-02 7.39e-01
Maturation of spike protein 9683686 5 8.07e-01 -6.31e-02 9.11e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 4.91e-01 6.29e-02 7.10e-01
Signaling by RAS mutants 40 4.91e-01 6.29e-02 7.10e-01
Signaling by moderate kinase activity BRAF mutants 40 4.91e-01 6.29e-02 7.10e-01
Signaling downstream of RAS mutants 40 4.91e-01 6.29e-02 7.10e-01
Intrinsic Pathway for Apoptosis 53 4.29e-01 -6.28e-02 6.66e-01
IL-6-type cytokine receptor ligand interactions 12 7.07e-01 -6.28e-02 8.55e-01
Signaling by NTRKs 116 2.45e-01 6.25e-02 4.89e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 7.20e-01 -6.24e-02 8.61e-01
Synthesis of substrates in N-glycan biosythesis 58 4.13e-01 6.21e-02 6.56e-01
SCF(Skp2)-mediated degradation of p27/p21 50 4.48e-01 -6.21e-02 6.77e-01
Somitogenesis 41 4.93e-01 -6.18e-02 7.13e-01
Cell death signalling via NRAGE, NRIF and NADE 69 3.75e-01 6.18e-02 6.18e-01
Amyloid fiber formation 51 4.46e-01 6.17e-02 6.76e-01
Neurotransmitter clearance 6 7.94e-01 6.15e-02 9.01e-01
Signaling by TGFBR3 39 5.08e-01 6.12e-02 7.22e-01
Opioid Signalling 74 3.63e-01 6.11e-02 6.10e-01
Inflammasomes 21 6.28e-01 6.11e-02 8.00e-01
Reproduction 84 3.34e-01 -6.10e-02 5.87e-01
NGF-stimulated transcription 32 5.51e-01 6.09e-02 7.44e-01
Displacement of DNA glycosylase by APEX1 9 7.52e-01 6.09e-02 8.79e-01
TGFBR3 expression 20 6.38e-01 6.08e-02 8.04e-01
Transferrin endocytosis and recycling 26 5.93e-01 6.05e-02 7.74e-01
Apoptotic cleavage of cellular proteins 35 5.37e-01 -6.04e-02 7.34e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 4.31e-01 -6.03e-02 6.67e-01
Fatty acyl-CoA biosynthesis 35 5.37e-01 6.03e-02 7.34e-01
FasL/ CD95L signaling 5 8.16e-01 -6.02e-02 9.18e-01
Ca2+ pathway 57 4.33e-01 6.01e-02 6.70e-01
Sphingolipid de novo biosynthesis 34 5.46e-01 -5.99e-02 7.41e-01
Signaling by WNT 237 1.12e-01 5.99e-02 3.18e-01
Tandem pore domain potassium channels 5 8.17e-01 5.98e-02 9.19e-01
Cytoprotection by HMOX1 53 4.52e-01 5.97e-02 6.82e-01
FGFR1b ligand binding and activation 5 8.17e-01 5.96e-02 9.19e-01
TGFBR3 PTM regulation 10 7.45e-01 5.95e-02 8.74e-01
PI3K/AKT activation 8 7.72e-01 5.93e-02 8.87e-01
Peptide hormone metabolism 53 4.59e-01 -5.88e-02 6.88e-01
Interleukin-17 signaling 68 4.03e-01 -5.87e-02 6.46e-01
Deposition of new CENPA-containing nucleosomes at the centromere 37 5.37e-01 -5.86e-02 7.34e-01
Nucleosome assembly 37 5.37e-01 -5.86e-02 7.34e-01
Synthesis of 5-eicosatetraenoic acids 7 7.89e-01 5.84e-02 8.97e-01
RNA Polymerase II Transcription 1185 7.22e-04 -5.84e-02 9.84e-03
HCMV Late Events 67 4.09e-01 -5.83e-02 6.52e-01
Signaling by NOTCH 173 1.86e-01 5.83e-02 4.19e-01
Synthesis of PIPs at the plasma membrane 52 4.67e-01 -5.82e-02 6.98e-01
Oncogenic MAPK signaling 75 3.84e-01 -5.81e-02 6.27e-01
MASTL Facilitates Mitotic Progression 10 7.50e-01 -5.81e-02 8.78e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 7.63e-01 5.80e-02 8.86e-01
Cellular responses to stress 694 9.33e-03 -5.79e-02 6.39e-02
Gastrin-CREB signalling pathway via PKC and MAPK 14 7.11e-01 5.72e-02 8.57e-01
Nicotinamide salvaging 15 7.03e-01 -5.69e-02 8.52e-01
Prolonged ERK activation events 13 7.23e-01 -5.67e-02 8.61e-01
Ion transport by P-type ATPases 41 5.31e-01 5.66e-02 7.31e-01
Toxicity of botulinum toxin type D (botD) 5 8.27e-01 -5.65e-02 9.19e-01
Toxicity of botulinum toxin type F (botF) 5 8.27e-01 -5.65e-02 9.19e-01
Deubiquitination 225 1.46e-01 -5.63e-02 3.61e-01
Nuclear signaling by ERBB4 24 6.34e-01 5.62e-02 8.01e-01
Golgi-to-ER retrograde transport 123 2.83e-01 5.61e-02 5.31e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.42e-01 -5.60e-02 8.07e-01
FGFR2 ligand binding and activation 9 7.71e-01 5.59e-02 8.87e-01
Cell Cycle, Mitotic 487 3.47e-02 -5.59e-02 1.50e-01
TP53 Regulates Transcription of Cell Death Genes 42 5.33e-01 5.56e-02 7.32e-01
RHOJ GTPase cycle 49 5.01e-01 5.55e-02 7.17e-01
Association of TriC/CCT with target proteins during biosynthesis 35 5.71e-01 -5.53e-02 7.60e-01
Signaling by MAPK mutants 6 8.15e-01 -5.53e-02 9.18e-01
Transport of vitamins, nucleosides, and related molecules 31 5.96e-01 5.51e-02 7.76e-01
Interleukin-1 signaling 99 3.44e-01 -5.50e-02 5.92e-01
Insulin receptor signalling cascade 40 5.48e-01 5.49e-02 7.43e-01
UCH proteinases 73 4.18e-01 -5.48e-02 6.60e-01
COPI-independent Golgi-to-ER retrograde traffic 45 5.27e-01 5.45e-02 7.30e-01
Heme signaling 45 5.28e-01 -5.44e-02 7.30e-01
Inactivation of CSF3 (G-CSF) signaling 24 6.45e-01 -5.43e-02 8.10e-01
Estrogen-dependent gene expression 96 3.58e-01 5.43e-02 6.03e-01
SUMO E3 ligases SUMOylate target proteins 161 2.35e-01 -5.42e-02 4.80e-01
Hedgehog ‘on’ state 65 4.52e-01 -5.39e-02 6.82e-01
Activation of BAD and translocation to mitochondria 15 7.18e-01 5.39e-02 8.60e-01
Negative epigenetic regulation of rRNA expression 63 4.61e-01 -5.36e-02 6.90e-01
Defective pyroptosis 27 6.30e-01 -5.35e-02 8.01e-01
Regulation of pyruvate metabolism 32 6.01e-01 -5.34e-02 7.80e-01
Signaling by NTRK3 (TRKC) 15 7.22e-01 5.31e-02 8.61e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 6.50e-01 5.24e-02 8.14e-01
CD28 dependent PI3K/Akt signaling 22 6.71e-01 5.23e-02 8.28e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 5.78e-01 5.22e-02 7.64e-01
Downstream signaling of activated FGFR4 18 7.01e-01 -5.22e-02 8.51e-01
NF-kB is activated and signals survival 12 7.56e-01 5.18e-02 8.82e-01
Infectious disease 951 6.99e-03 -5.17e-02 5.21e-02
Vesicle-mediated transport 663 2.49e-02 5.11e-02 1.23e-01
Heme biosynthesis 13 7.50e-01 5.10e-02 8.78e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 5.25e-01 5.05e-02 7.29e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 5.25e-01 5.05e-02 7.29e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 5.25e-01 5.05e-02 7.29e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 5.25e-01 5.05e-02 7.29e-01
Signaling by NOTCH1 in Cancer 53 5.25e-01 5.05e-02 7.29e-01
ROBO receptors bind AKAP5 7 8.20e-01 -4.97e-02 9.19e-01
Signaling by BRAF and RAF1 fusions 59 5.10e-01 -4.96e-02 7.22e-01
Activation of BH3-only proteins 29 6.45e-01 4.94e-02 8.10e-01
RAS processing 23 6.82e-01 -4.93e-02 8.37e-01
PKMTs methylate histone lysines 42 5.80e-01 -4.93e-02 7.65e-01
Signaling by Nuclear Receptors 210 2.20e-01 4.91e-02 4.60e-01
SUMOylation of intracellular receptors 26 6.67e-01 4.87e-02 8.28e-01
Activated NTRK2 signals through FRS2 and FRS3 8 8.13e-01 -4.84e-02 9.16e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 8.38e-01 4.83e-02 9.23e-01
COPI-mediated anterograde transport 92 4.24e-01 4.83e-02 6.63e-01
Regulation of TP53 Degradation 35 6.22e-01 -4.82e-02 7.96e-01
Signaling by TGFB family members 137 3.31e-01 4.81e-02 5.87e-01
Acyl chain remodelling of PE 19 7.17e-01 4.80e-02 8.60e-01
FOXO-mediated transcription 57 5.31e-01 4.80e-02 7.31e-01
Amino acid transport across the plasma membrane 24 6.86e-01 4.76e-02 8.39e-01
cGMP effects 12 7.78e-01 4.71e-02 8.90e-01
RAS signaling downstream of NF1 loss-of-function variants 7 8.29e-01 4.71e-02 9.19e-01
Signal regulatory protein family interactions 13 7.69e-01 4.70e-02 8.87e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 4.19e-01 -4.68e-02 6.60e-01
Regulated proteolysis of p75NTR 11 7.88e-01 4.68e-02 8.97e-01
Circadian Clock 67 5.11e-01 4.64e-02 7.22e-01
G1/S Transition 120 3.80e-01 -4.64e-02 6.23e-01
TGF-beta receptor signaling activates SMADs 45 5.91e-01 4.63e-02 7.72e-01
Signaling by NTRK1 (TRKA) 102 4.19e-01 4.63e-02 6.60e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 5.97e-01 4.61e-02 7.76e-01
Extra-nuclear estrogen signaling 65 5.20e-01 4.61e-02 7.28e-01
Late SARS-CoV-2 Infection Events 63 5.27e-01 4.60e-02 7.30e-01
Negative regulation of MAPK pathway 42 6.06e-01 -4.60e-02 7.82e-01
Nef and signal transduction 8 8.22e-01 -4.58e-02 9.19e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 4.18e-01 -4.58e-02 6.60e-01
Immune System 1828 1.20e-03 4.58e-02 1.39e-02
Regulation of signaling by CBL 22 7.12e-01 4.55e-02 8.57e-01
Death Receptor Signaling 145 3.45e-01 4.55e-02 5.92e-01
Ovarian tumor domain proteases 37 6.34e-01 4.53e-02 8.01e-01
GPVI-mediated activation cascade 31 6.63e-01 4.52e-02 8.25e-01
HCMV Early Events 84 4.77e-01 -4.49e-02 7.00e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 6.82e-01 4.48e-02 8.37e-01
Condensation of Prometaphase Chromosomes 11 7.97e-01 4.47e-02 9.04e-01
MyD88 dependent cascade initiated on endosome 101 4.38e-01 -4.47e-02 6.73e-01
Signaling by Retinoic Acid 29 6.78e-01 -4.46e-02 8.34e-01
Signaling by Non-Receptor Tyrosine Kinases 47 5.97e-01 4.45e-02 7.76e-01
Signaling by PTK6 47 5.97e-01 4.45e-02 7.76e-01
RHO GTPases Activate ROCKs 18 7.44e-01 4.45e-02 8.74e-01
RND2 GTPase cycle 36 6.44e-01 4.45e-02 8.10e-01
Noncanonical activation of NOTCH3 8 8.28e-01 4.44e-02 9.19e-01
HSF1 activation 25 7.01e-01 4.44e-02 8.51e-01
VEGFR2 mediated cell proliferation 18 7.45e-01 -4.43e-02 8.74e-01
Attachment of GPI anchor to uPAR 7 8.39e-01 4.42e-02 9.23e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 6.09e-02 4.41e-02 2.16e-01
CDH11 homotypic and heterotypic interactions 5 8.65e-01 4.41e-02 9.35e-01
Post-translational protein modification 1232 9.34e-03 -4.40e-02 6.39e-02
HS-GAG degradation 18 7.47e-01 4.40e-02 8.76e-01
MAPK1/MAPK3 signaling 227 2.54e-01 4.39e-02 5.02e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 5.72e-01 -4.37e-02 7.60e-01
Bacterial Infection Pathways 65 5.43e-01 -4.36e-02 7.39e-01
Interleukin-12 family signaling 53 5.84e-01 -4.35e-02 7.67e-01
DCC mediated attractive signaling 13 7.86e-01 -4.35e-02 8.97e-01
SHC-mediated cascade:FGFR3 10 8.12e-01 -4.34e-02 9.16e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 7.44e-01 -4.32e-02 8.74e-01
Trafficking of AMPA receptors 19 7.44e-01 -4.32e-02 8.74e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 8.43e-01 -4.32e-02 9.25e-01
Activation of NMDA receptors and postsynaptic events 70 5.35e-01 4.29e-02 7.34e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 7.54e-01 -4.27e-02 8.80e-01
Asymmetric localization of PCP proteins 49 6.05e-01 -4.27e-02 7.82e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 8.35e-01 4.26e-02 9.23e-01
Signaling by Rho GTPases 603 7.70e-02 4.22e-02 2.56e-01
Transport to the Golgi and subsequent modification 170 3.43e-01 4.22e-02 5.92e-01
Rab regulation of trafficking 122 4.22e-01 4.21e-02 6.63e-01
COPII-mediated vesicle transport 67 5.52e-01 -4.21e-02 7.44e-01
Generic Transcription Pathway 1067 2.04e-02 -4.21e-02 1.10e-01
Signaling by ERBB2 ECD mutants 15 7.78e-01 -4.21e-02 8.90e-01
CLEC7A/inflammasome pathway 6 8.59e-01 4.19e-02 9.33e-01
Intracellular signaling by second messengers 264 2.42e-01 4.18e-02 4.88e-01
CS/DS degradation 9 8.28e-01 -4.18e-02 9.19e-01
FOXO-mediated transcription of cell cycle genes 14 7.87e-01 -4.16e-02 8.97e-01
RHO GTPases activate PAKs 20 7.48e-01 4.16e-02 8.76e-01
RAF/MAP kinase cascade 222 2.86e-01 4.16e-02 5.35e-01
RHO GTPases activate PKNs 46 6.26e-01 4.15e-02 7.99e-01
Transcriptional activation of mitochondrial biogenesis 52 6.05e-01 -4.15e-02 7.82e-01
RHO GTPase Effectors 257 2.53e-01 4.14e-02 5.02e-01
PI3K Cascade 31 6.91e-01 4.13e-02 8.42e-01
Signaling by FLT3 fusion proteins 18 7.62e-01 -4.12e-02 8.85e-01
Uptake and function of diphtheria toxin 6 8.61e-01 4.12e-02 9.35e-01
RHO GTPase cycle 408 1.56e-01 4.09e-02 3.78e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 7.01e-01 4.05e-02 8.51e-01
Fertilization 12 8.08e-01 4.05e-02 9.12e-01
Regulation of NF-kappa B signaling 18 7.70e-01 -3.98e-02 8.87e-01
Uptake and actions of bacterial toxins 27 7.21e-01 3.98e-02 8.61e-01
MECP2 regulates transcription factors 5 8.78e-01 -3.97e-02 9.41e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 6.31e-01 -3.96e-02 8.01e-01
Pyroptosis 24 7.37e-01 -3.96e-02 8.72e-01
SHC-mediated cascade:FGFR2 13 8.05e-01 -3.95e-02 9.10e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 5.94e-01 -3.92e-02 7.74e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 6.84e-01 -3.91e-02 8.38e-01
Regulation of endogenous retroelements 92 5.19e-01 3.89e-02 7.27e-01
Synthesis of PG 8 8.49e-01 3.89e-02 9.27e-01
CTLA4 inhibitory signaling 21 7.58e-01 -3.88e-02 8.82e-01
Costimulation by the CD28 family 74 5.68e-01 -3.84e-02 7.58e-01
Metabolism of vitamins and cofactors 163 4.03e-01 3.80e-02 6.46e-01
Diseases associated with N-glycosylation of proteins 20 7.69e-01 -3.80e-02 8.87e-01
WNT ligand biogenesis and trafficking 20 7.69e-01 3.80e-02 8.87e-01
ERBB2 Activates PTK6 Signaling 8 8.54e-01 3.76e-02 9.31e-01
Interleukin-6 signaling 10 8.37e-01 -3.76e-02 9.23e-01
RHOH GTPase cycle 33 7.10e-01 -3.74e-02 8.57e-01
Metabolism 1808 8.38e-03 -3.74e-02 5.92e-02
Phospholipid metabolism 182 3.89e-01 -3.70e-02 6.32e-01
Signaling by FGFR3 32 7.17e-01 -3.70e-02 8.60e-01
Transcriptional regulation of pluripotent stem cells 18 7.86e-01 -3.70e-02 8.97e-01
Cellular responses to stimuli 776 8.01e-02 -3.70e-02 2.62e-01
Glucose metabolism 76 5.81e-01 3.66e-02 7.65e-01
Clathrin-mediated endocytosis 127 4.76e-01 -3.66e-02 7.00e-01
ESR-mediated signaling 157 4.29e-01 3.66e-02 6.66e-01
Transcriptional Regulation by VENTX 38 6.98e-01 -3.64e-02 8.49e-01
Sulfur amino acid metabolism 22 7.68e-01 3.64e-02 8.87e-01
Metabolism of steroid hormones 21 7.74e-01 -3.62e-02 8.89e-01
HCMV Infection 106 5.21e-01 -3.61e-02 7.29e-01
KEAP1-NFE2L2 pathway 106 5.22e-01 3.60e-02 7.29e-01
Aflatoxin activation and detoxification 14 8.17e-01 3.58e-02 9.19e-01
Signaling by FGFR4 32 7.27e-01 -3.56e-02 8.64e-01
Mucopolysaccharidoses 11 8.38e-01 3.56e-02 9.23e-01
NoRC negatively regulates rRNA expression 60 6.33e-01 -3.56e-02 8.01e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 7.28e-01 3.55e-02 8.65e-01
IRS-related events triggered by IGF1R 36 7.14e-01 3.53e-02 8.59e-01
RNA Polymerase I Promoter Escape 45 6.83e-01 -3.52e-02 8.37e-01
Initiation of Nuclear Envelope (NE) Reformation 19 7.91e-01 3.51e-02 8.98e-01
Molybdenum cofactor biosynthesis 6 8.82e-01 -3.49e-02 9.43e-01
IGF1R signaling cascade 37 7.15e-01 3.47e-02 8.59e-01
Nuclear Events (kinase and transcription factor activation) 54 6.62e-01 3.44e-02 8.24e-01
MyD88 cascade initiated on plasma membrane 95 5.63e-01 -3.44e-02 7.54e-01
Toll Like Receptor 10 (TLR10) Cascade 95 5.63e-01 -3.44e-02 7.54e-01
Toll Like Receptor 5 (TLR5) Cascade 95 5.63e-01 -3.44e-02 7.54e-01
Constitutive Signaling by Overexpressed ERBB2 11 8.44e-01 3.43e-02 9.25e-01
SHC-related events triggered by IGF1R 7 8.75e-01 3.42e-02 9.40e-01
SARS-CoV Infections 428 2.26e-01 -3.42e-02 4.66e-01
p75NTR negatively regulates cell cycle via SC1 5 8.95e-01 -3.41e-02 9.47e-01
ADP signalling through P2Y purinoceptor 12 18 8.03e-01 3.40e-02 9.09e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.27e-01 3.39e-02 7.30e-01
Metabolism of nucleotides 86 5.87e-01 -3.39e-02 7.69e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 7.90e-01 -3.36e-02 8.97e-01
Diseases associated with glycosaminoglycan metabolism 24 7.76e-01 3.35e-02 8.90e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 8.88e-01 3.31e-02 9.45e-01
RHOF GTPase cycle 38 7.25e-01 3.30e-02 8.62e-01
RHOT2 GTPase cycle 7 8.81e-01 3.28e-02 9.42e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 8.90e-01 -3.26e-02 9.45e-01
TRAF6 mediated NF-kB activation 23 7.87e-01 3.25e-02 8.97e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 8.40e-01 3.23e-02 9.23e-01
TNFR1-mediated ceramide production 6 8.92e-01 -3.21e-02 9.46e-01
G beta:gamma signalling through CDC42 17 8.20e-01 -3.20e-02 9.19e-01
Amino acids regulate mTORC1 48 7.03e-01 -3.19e-02 8.52e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 8.55e-01 3.18e-02 9.31e-01
FRS-mediated FGFR3 signaling 12 8.50e-01 -3.15e-02 9.28e-01
Signaling by MET 67 6.58e-01 -3.13e-02 8.20e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.29e-01 3.11e-02 9.19e-01
Signaling by CSF3 (G-CSF) 29 7.72e-01 -3.11e-02 8.87e-01
Glycogen storage diseases 13 8.47e-01 3.10e-02 9.27e-01
Diseases of mitotic cell cycle 38 7.42e-01 -3.09e-02 8.74e-01
PIP3 activates AKT signaling 232 4.19e-01 3.08e-02 6.60e-01
FRS-mediated FGFR2 signaling 15 8.38e-01 -3.05e-02 9.23e-01
RUNX3 regulates CDKN1A transcription 7 8.89e-01 3.04e-02 9.45e-01
Frs2-mediated activation 11 8.62e-01 -3.03e-02 9.35e-01
PCP/CE pathway 74 6.55e-01 3.01e-02 8.17e-01
PRC2 methylates histones and DNA 27 7.88e-01 2.99e-02 8.97e-01
RAB geranylgeranylation 62 6.85e-01 -2.98e-02 8.38e-01
Biological oxidations 135 5.53e-01 -2.96e-02 7.44e-01
Cyclin E associated events during G1/S transition 73 6.64e-01 -2.94e-02 8.26e-01
MITF-M-regulated melanocyte development 110 5.98e-01 2.91e-02 7.77e-01
Na+/Cl- dependent neurotransmitter transporters 7 8.95e-01 2.89e-02 9.47e-01
TICAM1-dependent activation of IRF3/IRF7 13 8.57e-01 2.89e-02 9.32e-01
Beta-catenin phosphorylation cascade 17 8.38e-01 -2.87e-02 9.23e-01
Beta-catenin independent WNT signaling 124 5.84e-01 2.84e-02 7.67e-01
Chaperone Mediated Autophagy 20 8.26e-01 2.83e-02 9.19e-01
Developmental Biology 906 1.50e-01 2.82e-02 3.68e-01
Degradation of beta-catenin by the destruction complex 72 6.80e-01 -2.81e-02 8.36e-01
Gastrulation 73 6.79e-01 -2.80e-02 8.34e-01
GRB2 events in ERBB2 signaling 11 8.74e-01 -2.76e-02 9.40e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 8.48e-01 -2.76e-02 9.27e-01
Prevention of phagosomal-lysosomal fusion 9 8.86e-01 -2.75e-02 9.44e-01
Pregnenolone biosynthesis 10 8.80e-01 2.75e-02 9.42e-01
Membrane binding and targetting of GAG proteins 13 8.64e-01 -2.74e-02 9.35e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 8.64e-01 -2.74e-02 9.35e-01
MET promotes cell motility 32 7.89e-01 -2.73e-02 8.97e-01
Cytokine Signaling in Immune system 662 2.38e-01 2.69e-02 4.83e-01
MyD88-independent TLR4 cascade 108 6.31e-01 -2.68e-02 8.01e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 6.31e-01 -2.68e-02 8.01e-01
ABC transporters in lipid homeostasis 14 8.63e-01 -2.65e-02 9.35e-01
Cellular response to chemical stress 178 5.42e-01 2.65e-02 7.39e-01
Nuclear Envelope (NE) Reassembly 68 7.08e-01 -2.63e-02 8.56e-01
Reversal of alkylation damage by DNA dioxygenases 7 9.04e-01 -2.63e-02 9.51e-01
Translation of Structural Proteins 9694635 55 7.41e-01 2.58e-02 8.74e-01
RHOG GTPase cycle 70 7.10e-01 2.57e-02 8.57e-01
Negative regulation of FGFR1 signaling 25 8.25e-01 2.56e-02 9.19e-01
GDP-fucose biosynthesis 6 9.14e-01 2.55e-02 9.59e-01
Maternal to zygotic transition (MZT) 71 7.11e-01 -2.54e-02 8.57e-01
Cell recruitment (pro-inflammatory response) 25 8.26e-01 2.53e-02 9.19e-01
Purinergic signaling in leishmaniasis infection 25 8.26e-01 2.53e-02 9.19e-01
Defective RIPK1-mediated regulated necrosis 7 9.08e-01 -2.53e-02 9.53e-01
NCAM signaling for neurite out-growth 47 7.64e-01 2.53e-02 8.86e-01
Cyclin D associated events in G1 47 7.64e-01 2.53e-02 8.86e-01
G1 Phase 47 7.64e-01 2.53e-02 8.86e-01
Mitotic G2-G2/M phases 179 5.66e-01 -2.49e-02 7.56e-01
Regulation of IFNG signaling 14 8.73e-01 -2.47e-02 9.40e-01
PTEN Regulation 126 6.34e-01 -2.46e-02 8.01e-01
Myoclonic epilepsy of Lafora 8 9.05e-01 2.43e-02 9.51e-01
Formation of paraxial mesoderm 52 7.62e-01 -2.43e-02 8.85e-01
Signaling by LTK 10 8.95e-01 2.42e-02 9.47e-01
Diseases associated with the TLR signaling cascade 29 8.22e-01 2.42e-02 9.19e-01
Diseases of Immune System 29 8.22e-01 2.42e-02 9.19e-01
Purine ribonucleoside monophosphate biosynthesis 9 9.00e-01 -2.41e-02 9.50e-01
activated TAK1 mediates p38 MAPK activation 23 8.41e-01 2.41e-02 9.24e-01
EPHA-mediated growth cone collapse 21 8.49e-01 -2.41e-02 9.27e-01
Signaling by FGFR 73 7.23e-01 -2.40e-02 8.61e-01
Metabolic disorders of biological oxidation enzymes 23 8.42e-01 2.40e-02 9.24e-01
Keratan sulfate degradation 9 9.02e-01 -2.36e-02 9.51e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 9.14e-01 2.35e-02 9.59e-01
Recruitment of NuMA to mitotic centrosomes 88 7.04e-01 2.34e-02 8.53e-01
Diseases of programmed cell death 58 7.60e-01 2.32e-02 8.83e-01
MAPK family signaling cascades 259 5.24e-01 2.30e-02 7.29e-01
Trafficking of GluR2-containing AMPA receptors 11 8.95e-01 2.30e-02 9.47e-01
Coenzyme A biosynthesis 7 9.17e-01 2.28e-02 9.59e-01
Transcriptional Regulation by NPAS4 27 8.37e-01 2.28e-02 9.23e-01
Phase I - Functionalization of compounds 62 7.57e-01 2.27e-02 8.82e-01
SIRT1 negatively regulates rRNA expression 22 8.55e-01 -2.26e-02 9.31e-01
G2/M Transition 177 6.05e-01 -2.26e-02 7.82e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 8.86e-01 2.21e-02 9.44e-01
Unfolded Protein Response (UPR) 84 7.29e-01 2.18e-02 8.65e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 8.76e-01 2.18e-02 9.40e-01
Disease 1606 1.47e-01 -2.18e-02 3.62e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 9.15e-01 -2.17e-02 9.59e-01
HIV elongation arrest and recovery 32 8.33e-01 -2.16e-02 9.22e-01
Pausing and recovery of HIV elongation 32 8.33e-01 -2.16e-02 9.22e-01
Regulation of TP53 Expression and Degradation 36 8.24e-01 -2.14e-02 9.19e-01
RAF-independent MAPK1/3 activation 21 8.66e-01 -2.13e-02 9.36e-01
TNFR2 non-canonical NF-kB pathway 84 7.36e-01 2.13e-02 8.71e-01
MET activates PTK2 signaling 21 8.67e-01 2.12e-02 9.36e-01
Positive epigenetic regulation of rRNA expression 60 7.77e-01 2.11e-02 8.90e-01
Interleukin-23 signaling 7 9.23e-01 2.11e-02 9.62e-01
Centrosome maturation 81 7.44e-01 -2.10e-02 8.74e-01
Recruitment of mitotic centrosome proteins and complexes 81 7.44e-01 -2.10e-02 8.74e-01
Cargo concentration in the ER 31 8.40e-01 -2.09e-02 9.23e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 9.24e-01 -2.08e-02 9.62e-01
Protein hydroxylation 17 8.82e-01 -2.08e-02 9.43e-01
RAC3 GTPase cycle 86 7.40e-01 -2.07e-02 8.74e-01
Defects in cobalamin (B12) metabolism 13 8.97e-01 -2.07e-02 9.48e-01
Synthesis of very long-chain fatty acyl-CoAs 22 8.67e-01 -2.06e-02 9.36e-01
Negative regulation of FGFR2 signaling 24 8.62e-01 -2.05e-02 9.35e-01
Metabolism of water-soluble vitamins and cofactors 114 7.15e-01 1.98e-02 8.59e-01
RUNX3 Regulates Immune Response and Cell Migration 5 9.39e-01 1.97e-02 9.74e-01
Negative regulation of FGFR3 signaling 21 8.76e-01 -1.96e-02 9.40e-01
Epigenetic regulation of gene expression 263 5.86e-01 -1.95e-02 7.68e-01
Interleukin-12 signaling 44 8.24e-01 -1.94e-02 9.19e-01
ERK/MAPK targets 22 8.76e-01 -1.93e-02 9.40e-01
Metabolism of steroids 120 7.20e-01 1.89e-02 8.61e-01
ER to Golgi Anterograde Transport 145 6.94e-01 1.89e-02 8.46e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 8.75e-01 1.89e-02 9.40e-01
Chromatin modifying enzymes 213 6.42e-01 -1.85e-02 8.07e-01
Chromatin organization 213 6.42e-01 -1.85e-02 8.07e-01
Toll-like Receptor Cascades 162 6.86e-01 -1.84e-02 8.39e-01
Diseases of carbohydrate metabolism 29 8.67e-01 1.79e-02 9.36e-01
Bile acid and bile salt metabolism 28 8.70e-01 -1.79e-02 9.37e-01
B-WICH complex positively regulates rRNA expression 45 8.39e-01 1.76e-02 9.23e-01
Reelin signalling pathway 5 9.46e-01 -1.73e-02 9.78e-01
RHOU GTPase cycle 40 8.52e-01 1.71e-02 9.29e-01
SHC1 events in ERBB2 signaling 17 9.03e-01 1.71e-02 9.51e-01
IRS-mediated signalling 35 8.64e-01 1.68e-02 9.35e-01
Cyclin A:Cdk2-associated events at S phase entry 75 8.05e-01 -1.65e-02 9.10e-01
FLT3 signaling in disease 27 8.83e-01 1.63e-02 9.44e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 9.26e-01 1.63e-02 9.63e-01
PKR-mediated signaling 67 8.18e-01 1.63e-02 9.19e-01
Glycerophospholipid biosynthesis 104 7.80e-01 -1.59e-02 8.92e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 9.15e-01 -1.59e-02 9.59e-01
DARPP-32 events 22 8.98e-01 -1.58e-02 9.48e-01
RNA Polymerase I Promoter Clearance 64 8.27e-01 -1.58e-02 9.19e-01
RNA Polymerase I Transcription 64 8.27e-01 -1.58e-02 9.19e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 7.77e-01 -1.58e-02 8.90e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 7.77e-01 -1.58e-02 8.90e-01
TRAF6 mediated IRF7 activation 15 9.17e-01 1.56e-02 9.59e-01
Negative feedback regulation of MAPK pathway 6 9.47e-01 -1.55e-02 9.78e-01
Cytochrome P450 - arranged by substrate type 33 8.78e-01 1.55e-02 9.41e-01
MET receptor recycling 9 9.36e-01 -1.54e-02 9.72e-01
Base Excision Repair 56 8.45e-01 -1.51e-02 9.26e-01
Loss of Nlp from mitotic centrosomes 69 8.29e-01 -1.51e-02 9.19e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 8.29e-01 -1.51e-02 9.19e-01
Phase 3 - rapid repolarisation 7 9.46e-01 1.47e-02 9.78e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 9.56e-01 1.43e-02 9.81e-01
Toll Like Receptor 3 (TLR3) Cascade 104 8.01e-01 -1.43e-02 9.08e-01
Downregulation of ERBB2 signaling 24 9.04e-01 -1.42e-02 9.51e-01
RHO GTPases Activate Formins 127 7.84e-01 -1.41e-02 8.96e-01
TNF signaling 56 8.57e-01 1.39e-02 9.32e-01
Signaling by ERBB2 TMD/JMD mutants 17 9.21e-01 -1.38e-02 9.62e-01
FGFR1 ligand binding and activation 10 9.40e-01 1.37e-02 9.75e-01
Interleukin-1 family signaling 127 7.93e-01 -1.35e-02 9.00e-01
MHC class II antigen presentation 113 8.05e-01 1.35e-02 9.10e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 8.89e-01 -1.34e-02 9.45e-01
Spry regulation of FGF signaling 16 9.26e-01 1.34e-02 9.63e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 8.48e-01 1.33e-02 9.27e-01
Glycosphingolipid metabolism 47 8.77e-01 1.31e-02 9.40e-01
Interleukin-6 family signaling 18 9.24e-01 1.31e-02 9.62e-01
Synthesis of PA 31 9.00e-01 -1.30e-02 9.50e-01
Toll Like Receptor 2 (TLR2) Cascade 109 8.19e-01 -1.27e-02 9.19e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 8.19e-01 -1.27e-02 9.19e-01
SUMOylation of transcription cofactors 44 8.91e-01 -1.20e-02 9.45e-01
Glutathione conjugation 26 9.16e-01 1.20e-02 9.59e-01
EPH-Ephrin signaling 79 8.55e-01 -1.19e-02 9.31e-01
Response of Mtb to phagocytosis 22 9.25e-01 1.17e-02 9.62e-01
Glycolysis 68 8.69e-01 1.16e-02 9.37e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 9.48e-01 1.14e-02 9.78e-01
RAC2 GTPase cycle 85 8.58e-01 1.13e-02 9.32e-01
Nephrin family interactions 19 9.33e-01 1.12e-02 9.69e-01
NCAM1 interactions 26 9.22e-01 1.10e-02 9.62e-01
Signaling by Hedgehog 120 8.38e-01 1.08e-02 9.23e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 8.95e-01 1.07e-02 9.47e-01
Blood group systems biosynthesis 16 9.41e-01 -1.07e-02 9.75e-01
Mitotic G1 phase and G1/S transition 138 8.32e-01 -1.05e-02 9.21e-01
CASP8 activity is inhibited 11 9.52e-01 -1.05e-02 9.80e-01
Dimerization of procaspase-8 11 9.52e-01 -1.05e-02 9.80e-01
Regulation by c-FLIP 11 9.52e-01 -1.05e-02 9.80e-01
Oncogene Induced Senescence 33 9.21e-01 9.99e-03 9.62e-01
Activated point mutants of FGFR2 7 9.64e-01 -9.98e-03 9.86e-01
Activation of HOX genes during differentiation 68 8.88e-01 -9.88e-03 9.45e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 8.88e-01 -9.88e-03 9.45e-01
Nervous system development 473 7.14e-01 -9.83e-03 8.59e-01
Downregulation of ERBB2:ERBB3 signaling 12 9.55e-01 -9.41e-03 9.81e-01
The NLRP3 inflammasome 16 9.48e-01 -9.38e-03 9.78e-01
Inositol phosphate metabolism 42 9.20e-01 8.95e-03 9.62e-01
VxPx cargo-targeting to cilium 19 9.46e-01 -8.95e-03 9.78e-01
Signaling by TGF-beta Receptor Complex 90 8.84e-01 8.88e-03 9.44e-01
Membrane Trafficking 575 7.17e-01 -8.85e-03 8.60e-01
FRS-mediated FGFR4 signaling 13 9.56e-01 8.82e-03 9.81e-01
Diseases of signal transduction by growth factor receptors and second messengers 399 7.66e-01 8.70e-03 8.87e-01
MyD88 deficiency (TLR2/4) 14 9.55e-01 -8.62e-03 9.81e-01
Metabolism of lipids 632 7.22e-01 -8.29e-03 8.61e-01
Miro GTPase Cycle 8 9.68e-01 -8.23e-03 9.87e-01
Transcriptional regulation by RUNX2 87 8.96e-01 8.11e-03 9.47e-01
PPARA activates gene expression 105 8.86e-01 8.11e-03 9.44e-01
Regulation of lipid metabolism by PPARalpha 107 8.86e-01 8.02e-03 9.44e-01
RHOD GTPase cycle 49 9.24e-01 -7.83e-03 9.62e-01
Pentose phosphate pathway 13 9.62e-01 -7.71e-03 9.84e-01
FGFR2c ligand binding and activation 5 9.78e-01 7.13e-03 9.90e-01
Translation of Structural Proteins 9683701 29 9.50e-01 -6.74e-03 9.79e-01
Downstream signaling of activated FGFR1 22 9.57e-01 -6.62e-03 9.81e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 9.49e-01 6.24e-03 9.79e-01
Toll Like Receptor 4 (TLR4) Cascade 138 9.03e-01 6.03e-03 9.51e-01
Inhibition of DNA recombination at telomere 33 9.53e-01 -5.99e-03 9.80e-01
DNA Double Strand Break Response 47 9.45e-01 -5.81e-03 9.78e-01
Axon guidance 455 8.39e-01 -5.57e-03 9.23e-01
TNFR1-induced NF-kappa-B signaling pathway 32 9.57e-01 5.47e-03 9.81e-01
Assembly Of The HIV Virion 15 9.72e-01 5.30e-03 9.90e-01
Josephin domain DUBs 10 9.77e-01 5.28e-03 9.90e-01
SHC-mediated cascade:FGFR4 11 9.76e-01 5.26e-03 9.90e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 9.04e-01 5.08e-03 9.51e-01
EPH-ephrin mediated repulsion of cells 42 9.55e-01 -5.07e-03 9.81e-01
Glycogen metabolism 21 9.69e-01 4.92e-03 9.88e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 9.81e-01 -4.88e-03 9.92e-01
Purine salvage 12 9.77e-01 -4.72e-03 9.90e-01
RND3 GTPase cycle 35 9.65e-01 4.24e-03 9.87e-01
Lysosome Vesicle Biogenesis 32 9.67e-01 4.21e-03 9.87e-01
Sphingolipid metabolism 92 9.46e-01 4.10e-03 9.78e-01
FRS-mediated FGFR1 signaling 15 9.78e-01 4.09e-03 9.90e-01
Negative regulation of FGFR4 signaling 22 9.76e-01 3.66e-03 9.90e-01
AURKA Activation by TPX2 72 9.59e-01 3.50e-03 9.82e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 9.66e-01 3.45e-03 9.87e-01
Regulation of MECP2 expression and activity 28 9.75e-01 -3.36e-03 9.90e-01
Role of ABL in ROBO-SLIT signaling 6 9.89e-01 -3.18e-03 9.95e-01
Detoxification of Reactive Oxygen Species 30 9.76e-01 3.17e-03 9.90e-01
FLT3 signaling by CBL mutants 7 9.90e-01 2.80e-03 9.95e-01
Meiotic synapsis 43 9.75e-01 2.71e-03 9.90e-01
Signaling by EGFR in Cancer 22 9.83e-01 2.67e-03 9.92e-01
Signaling by FGFR1 42 9.76e-01 2.66e-03 9.90e-01
Asparagine N-linked glycosylation 284 9.39e-01 -2.65e-03 9.74e-01
p75NTR signals via NF-kB 15 9.87e-01 2.52e-03 9.94e-01
Transcriptional regulation by RUNX3 80 9.69e-01 -2.49e-03 9.88e-01
Infection with Mycobacterium tuberculosis 26 9.83e-01 -2.46e-03 9.92e-01
Hedgehog ‘off’ state 91 9.68e-01 -2.44e-03 9.87e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 9.78e-01 -2.35e-03 9.90e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.83e-01 -2.30e-03 9.92e-01
Tat-mediated HIV elongation arrest and recovery 30 9.83e-01 -2.30e-03 9.92e-01
Metal ion SLC transporters 19 9.87e-01 2.23e-03 9.94e-01
MET activates RAS signaling 10 9.91e-01 2.17e-03 9.95e-01
Adaptive Immune System 765 9.23e-01 2.07e-03 9.62e-01
TAK1-dependent IKK and NF-kappa-B activation 43 9.83e-01 -1.89e-03 9.92e-01
Lewis blood group biosynthesis 13 9.91e-01 1.80e-03 9.95e-01
CD28 co-stimulation 33 9.87e-01 1.67e-03 9.94e-01
MECP2 regulates transcription of neuronal ligands 5 9.95e-01 -1.60e-03 9.97e-01
G-protein beta:gamma signalling 29 9.90e-01 -1.36e-03 9.95e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 9.95e-01 -1.28e-03 9.97e-01
Fatty acid metabolism 152 9.81e-01 -1.13e-03 9.92e-01
RHO GTPases Activate WASPs and WAVEs 35 9.92e-01 -1.04e-03 9.95e-01
RAB GEFs exchange GTP for GDP on RABs 89 9.89e-01 -8.25e-04 9.95e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 9.94e-01 5.69e-04 9.97e-01
SHC-mediated cascade:FGFR1 13 9.98e-01 3.48e-04 1.00e+00
ERKs are inactivated 13 9.99e-01 -1.74e-04 1.00e+00
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 9.99e-01 9.70e-05 1.00e+00
Vitamin D (calciferol) metabolism 10 1.00e+00 -4.71e-05 1.00e+00


Detailed Gene set reports



Erythrocytes take up oxygen and release carbon dioxide
set Erythrocytes take up oxygen and release carbon dioxide
setSize 7
pANOVA 0.000245
s.dist 0.8
p.adjustANOVA 0.00385


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC4A1 10921
CA1 10911
HBA1 10886
HBB 10875
CA4 10587
AQP1 9052
CA2 -736

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All member genes
GeneID Gene Rank
SLC4A1 10921
CA1 10911
HBA1 10886
HBB 10875
CA4 10587
AQP1 9052
CA2 -736


Biosynthesis of Lipoxins (LX)
set Biosynthesis of Lipoxins (LX)
setSize 6
pANOVA 0.00189
s.dist 0.732
p.adjustANOVA 0.0194


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 10882
PTGR1 10748
HPGD 9736
LTC4S 6988
ALOX12 5774
ALOX5AP 5102

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All member genes
GeneID Gene Rank
ALOX5 10882
PTGR1 10748
HPGD 9736
LTC4S 6988
ALOX12 5774
ALOX5AP 5102


Propionyl-CoA catabolism
set Propionyl-CoA catabolism
setSize 5
pANOVA 0.00527
s.dist -0.721
p.adjustANOVA 0.0432


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCEE -9884
PCCB -9751
MMAA -5925
MMUT -5605
PCCA -4983

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All member genes
GeneID Gene Rank
MCEE -9884
PCCB -9751
MMAA -5925
MMUT -5605
PCCA -4983


Defects of platelet adhesion to exposed collagen
set Defects of platelet adhesion to exposed collagen
setSize 6
pANOVA 0.00624
s.dist 0.645
p.adjustANOVA 0.0491


Top enriched genes
Top 20 genes
GeneID Gene Rank
ADAMTS13 10052
GP1BB 9254
GP9 9198
GP1BA 7464
GP5 5530
VWF 2144

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All member genes
GeneID Gene Rank
ADAMTS13 10052
GP1BB 9254
GP9 9198
GP1BA 7464
GP5 5530
VWF 2144


Phosphorylation of Emi1
set Phosphorylation of Emi1
setSize 6
pANOVA 0.00743
s.dist 0.631
p.adjustANOVA 0.0543


Top enriched genes
Top 20 genes
GeneID Gene Rank
FZR1 10155
PLK1 9583
CDC20 9014
CCNB1 6954
CDK1 6306
FBXO5 760

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All member genes
GeneID Gene Rank
FZR1 10155
PLK1 9583
CDC20 9014
CCNB1 6954
CDK1 6306
FBXO5 760


Defective GALNT3 causes HFTC
set Defective GALNT3 causes HFTC
setSize 8
pANOVA 0.00221
s.dist 0.625
p.adjustANOVA 0.0217


Top enriched genes
Top 20 genes
GeneID Gene Rank
MUC1 11035
MUC6 8257
MUC4 8206
MUC5B 8108
MUC20 6167
MUC12 5650
GALNT3 5189
MUC16 3892

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All member genes
GeneID Gene Rank
MUC1 11035
MUC6 8257
MUC4 8206
MUC5B 8108
MUC20 6167
MUC12 5650
GALNT3 5189
MUC16 3892


Synthesis of wybutosine at G37 of tRNA(Phe)
set Synthesis of wybutosine at G37 of tRNA(Phe)
setSize 6
pANOVA 0.00873
s.dist -0.618
p.adjustANOVA 0.0603


Top enriched genes
Top 20 genes
GeneID Gene Rank
TYW5 -9797
TYW1 -8744
TYW3 -7700
TRMT5 -6811
LCMT2 -2349
TRMT12 -1452

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All member genes
GeneID Gene Rank
TYW5 -9797
TYW1 -8744
TYW3 -7700
TRMT5 -6811
LCMT2 -2349
TRMT12 -1452


CD163 mediating an anti-inflammatory response
set CD163 mediating an anti-inflammatory response
setSize 8
pANOVA 0.00311
s.dist 0.604
p.adjustANOVA 0.028


Top enriched genes
Top 20 genes
GeneID Gene Rank
FURIN 10607
RHBDF2 10542
IL10 9855
MAPK14 9632
MYH9 9072
CD163 6455
ADAM17 3779
PLK2 -5255

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FURIN 10607
RHBDF2 10542
IL10 9855
MAPK14 9632
MYH9 9072
CD163 6455
ADAM17 3779
PLK2 -5255


Wax and plasmalogen biosynthesis
set Wax and plasmalogen biosynthesis
setSize 5
pANOVA 0.0199
s.dist -0.601
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
GNPAT -8891
AGPS -7715
FAR2 -6246
FAR1 -6077
DHRS7B -876

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All member genes
GeneID Gene Rank
GNPAT -8891
AGPS -7715
FAR2 -6246
FAR1 -6077
DHRS7B -876


Removal of aminoterminal propeptides from gamma-carboxylated proteins
set Removal of aminoterminal propeptides from gamma-carboxylated proteins
setSize 6
pANOVA 0.0117
s.dist 0.594
p.adjustANOVA 0.076


Top enriched genes
Top 20 genes
GeneID Gene Rank
GAS6 11023
FURIN 10607
PROC 6884
PROZ 6064
BGLAP 4398
PROS1 1450

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All member genes
GeneID Gene Rank
GAS6 11023
FURIN 10607
PROC 6884
PROZ 6064
BGLAP 4398
PROS1 1450


Defective GALNT12 causes CRCS1
set Defective GALNT12 causes CRCS1
setSize 8
pANOVA 0.00361
s.dist 0.594
p.adjustANOVA 0.0317


Top enriched genes
Top 20 genes
GeneID Gene Rank
MUC1 11035
MUC6 8257
MUC4 8206
MUC5B 8108
MUC20 6167
MUC12 5650
MUC16 3892
GALNT12 2576

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MUC1 11035
MUC6 8257
MUC4 8206
MUC5B 8108
MUC20 6167
MUC12 5650
MUC16 3892
GALNT12 2576


Defective binding of VWF variant to GPIb:IX:V
set Defective binding of VWF variant to GPIb:IX:V
setSize 5
pANOVA 0.0218
s.dist 0.592
p.adjustANOVA 0.113


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BB 9254
GP9 9198
GP1BA 7464
GP5 5530
VWF 2144

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BB 9254
GP9 9198
GP1BA 7464
GP5 5530
VWF 2144


Enhanced binding of GP1BA variant to VWF multimer:collagen
set Enhanced binding of GP1BA variant to VWF multimer:collagen
setSize 5
pANOVA 0.0218
s.dist 0.592
p.adjustANOVA 0.113


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BB 9254
GP9 9198
GP1BA 7464
GP5 5530
VWF 2144

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BB 9254
GP9 9198
GP1BA 7464
GP5 5530
VWF 2144


Response to metal ions
set Response to metal ions
setSize 6
pANOVA 0.0136
s.dist 0.582
p.adjustANOVA 0.0838


Top enriched genes
Top 20 genes
GeneID Gene Rank
MT1E 9643
MT2A 9420
MTF1 8972
MT1X 7803
MT1F 5157
CSRP1 -1368

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All member genes
GeneID Gene Rank
MT1E 9643
MT2A 9420
MTF1 8972
MT1X 7803
MT1F 5157
CSRP1 -1368


Termination of O-glycan biosynthesis
set Termination of O-glycan biosynthesis
setSize 15
pANOVA 0.000115
s.dist 0.575
p.adjustANOVA 0.00191


Top enriched genes
Top 20 genes
GeneID Gene Rank
MUC1 11035
ST3GAL2 10485
ST3GAL4 10331
MUC6 8257
MUC4 8206
MUC5B 8108
ST3GAL1 8100
ST6GALNAC4 8071
ST6GALNAC3 6236
MUC20 6167
MUC12 5650
ST6GAL1 5452
MUC16 3892
ST3GAL3 2268
ST6GALNAC2 -4265

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MUC1 11035
ST3GAL2 10485
ST3GAL4 10331
MUC6 8257
MUC4 8206
MUC5B 8108
ST3GAL1 8100
ST6GALNAC4 8071
ST6GALNAC3 6236
MUC20 6167
MUC12 5650
ST6GAL1 5452
MUC16 3892
ST3GAL3 2268
ST6GALNAC2 -4265


Negative regulation of TCF-dependent signaling by DVL-interacting proteins
set Negative regulation of TCF-dependent signaling by DVL-interacting proteins
setSize 5
pANOVA 0.0269
s.dist 0.572
p.adjustANOVA 0.128


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL1 9175
DVL3 8783
CCDC88C 8531
DVL2 4896
CXXC4 1104

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DVL1 9175
DVL3 8783
CCDC88C 8531
DVL2 4896
CXXC4 1104


PDH complex synthesizes acetyl-CoA from PYR
set PDH complex synthesizes acetyl-CoA from PYR
setSize 5
pANOVA 0.0293
s.dist -0.563
p.adjustANOVA 0.136


Top enriched genes
Top 20 genes
GeneID Gene Rank
PDHX -9307
PDHB -8558
DLAT -4513
PDHA1 -3010
DLD -2375

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDHX -9307
PDHB -8558
DLAT -4513
PDHA1 -3010
DLD -2375


Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
set Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
setSize 12
pANOVA 0.000845
s.dist 0.556
p.adjustANOVA 0.0108


Top enriched genes
Top 20 genes
GeneID Gene Rank
TUBB2A 10351
TUBA1C 9049
TUBA1A 8085
TUBB3 7915
TUBA1B 7765
TUBA8 7540
TUBB6 7474
TUBA4A 5842
TUBB4A 5652
TUBB4B 5305
TUBB1 4950
TUBA4B -3920

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 10351
TUBA1C 9049
TUBA1A 8085
TUBB3 7915
TUBA1B 7765
TUBA8 7540
TUBB6 7474
TUBA4A 5842
TUBB4A 5652
TUBB4B 5305
TUBB1 4950
TUBA4B -3920


Transport of connexons to the plasma membrane
set Transport of connexons to the plasma membrane
setSize 12
pANOVA 0.000845
s.dist 0.556
p.adjustANOVA 0.0108


Top enriched genes
Top 20 genes
GeneID Gene Rank
TUBB2A 10351
TUBA1C 9049
TUBA1A 8085
TUBB3 7915
TUBA1B 7765
TUBA8 7540
TUBB6 7474
TUBA4A 5842
TUBB4A 5652
TUBB4B 5305
TUBB1 4950
TUBA4B -3920

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 10351
TUBA1C 9049
TUBA1A 8085
TUBB3 7915
TUBA1B 7765
TUBA8 7540
TUBB6 7474
TUBA4A 5842
TUBB4A 5652
TUBB4B 5305
TUBB1 4950
TUBA4B -3920


HDL remodeling
set HDL remodeling
setSize 6
pANOVA 0.0184
s.dist 0.556
p.adjustANOVA 0.103


Top enriched genes
Top 20 genes
GeneID Gene Rank
APOE 9952
CETP 9619
PLTP 8917
LCAT 8145
LIPG 2811
ABCG1 -1458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOE 9952
CETP 9619
PLTP 8917
LCAT 8145
LIPG 2811
ABCG1 -1458


Type I hemidesmosome assembly
set Type I hemidesmosome assembly
setSize 8
pANOVA 0.00696
s.dist 0.551
p.adjustANOVA 0.052


Top enriched genes
Top 20 genes
GeneID Gene Rank
CD151 10839
COL17A1 10343
ITGA6 10260
LAMB3 9745
PLEC 8916
ITGB4 6083
KRT5 -2026
DST -3937

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD151 10839
COL17A1 10343
ITGA6 10260
LAMB3 9745
PLEC 8916
ITGB4 6083
KRT5 -2026
DST -3937


SUMO is proteolytically processed
set SUMO is proteolytically processed
setSize 6
pANOVA 0.0199
s.dist -0.549
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
SENP5 -8903
SENP2 -8482
SUMO2 -8281
SENP1 -6015
SUMO1 -4465
SUMO3 3715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SENP5 -8903
SENP2 -8482
SUMO2 -8281
SENP1 -6015
SUMO1 -4465
SUMO3 3715


mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
set mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
setSize 6
pANOVA 0.0228
s.dist -0.537
p.adjustANOVA 0.116


Top enriched genes
Top 20 genes
GeneID Gene Rank
DECR1 -8433
HADHB -6954
HADHA -6661
ECI1 -6220
ACADM -2963
ACADL -426

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DECR1 -8433
HADHB -6954
HADHA -6661
ECI1 -6220
ACADM -2963
ACADL -426


G2/M DNA replication checkpoint
set G2/M DNA replication checkpoint
setSize 5
pANOVA 0.0379
s.dist 0.536
p.adjustANOVA 0.159


Top enriched genes
Top 20 genes
GeneID Gene Rank
PKMYT1 7059
CCNB1 6954
CDK1 6306
WEE1 6018
CCNB2 4258

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKMYT1 7059
CCNB1 6954
CDK1 6306
WEE1 6018
CCNB2 4258


Processing and activation of SUMO
set Processing and activation of SUMO
setSize 10
pANOVA 0.00392
s.dist -0.527
p.adjustANOVA 0.034


Top enriched genes
Top 20 genes
GeneID Gene Rank
SENP5 -8903
RWDD3 -8857
SENP2 -8482
SUMO2 -8281
UBA2 -6579
SENP1 -6015
SUMO1 -4465
SAE1 -3192
UBE2I -642
SUMO3 3715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SENP5 -8903
RWDD3 -8857
SENP2 -8482
SUMO2 -8281
UBA2 -6579
SENP1 -6015
SUMO1 -4465
SAE1 -3192
UBE2I -642
SUMO3 3715


Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
set Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
setSize 5
pANOVA 0.0435
s.dist 0.521
p.adjustANOVA 0.176


Top enriched genes
Top 20 genes
GeneID Gene Rank
GAS6 11023
PROC 6884
PROZ 6064
BGLAP 4398
PROS1 1450

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GAS6 11023
PROC 6884
PROZ 6064
BGLAP 4398
PROS1 1450


Vitamin B1 (thiamin) metabolism
set Vitamin B1 (thiamin) metabolism
setSize 5
pANOVA 0.0437
s.dist -0.521
p.adjustANOVA 0.176


Top enriched genes
Top 20 genes
GeneID Gene Rank
TPK1 -10168
THTPA -8954
SLC19A2 -8296
SLC19A3 -5445
SLC25A19 7321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPK1 -10168
THTPA -8954
SLC19A2 -8296
SLC19A3 -5445
SLC25A19 7321


Regulation of NFE2L2 gene expression
set Regulation of NFE2L2 gene expression
setSize 8
pANOVA 0.011
s.dist 0.519
p.adjustANOVA 0.0737


Top enriched genes
Top 20 genes
GeneID Gene Rank
NOTCH1 10877
MYC 10538
CREBBP 8586
MAFK 8267
RELA 7169
EP300 4881
NFKB1 739
NFE2L2 -3531

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH1 10877
MYC 10538
CREBBP 8586
MAFK 8267
RELA 7169
EP300 4881
NFKB1 739
NFE2L2 -3531


CD22 mediated BCR regulation
set CD22 mediated BCR regulation
setSize 58
pANOVA 1.01e-11
s.dist 0.516
p.adjustANOVA 1.08e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGKV2-29 10896
IGLV3-19 10705
IGLV3-1 10590
IGHV4-34 10498
IGLV1-40 10364
PTPN6 10297
CD22 10092
IGLC3 10075
IGKV5-2 9562
IGKV1D-39 9273
IGLV2-8 9257
IGHV2-5 9209
IGKV1-12 9172
IGHM 9169
IGHV4-59 9141
IGHV3-7 9137
CD79A 9027
IGHV3-13 9017
IGLV3-25 8894
IGHV1-69 8887

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV2-29 10896
IGLV3-19 10705
IGLV3-1 10590
IGHV4-34 10498
IGLV1-40 10364
PTPN6 10297
CD22 10092
IGLC3 10075
IGKV5-2 9562
IGKV1D-39 9273
IGLV2-8 9257
IGHV2-5 9209
IGKV1-12 9172
IGHM 9169
IGHV4-59 9141
IGHV3-7 9137
CD79A 9027
IGHV3-13 9017
IGLV3-25 8894
IGHV1-69 8887
IGKV3-15 8734
IGLC2 8682
IGHV2-70 8320
IGKV3-11 8120
IGKV1-5 7949
IGHV3-33 7286
IGHV1-46 7248
IGKV2-28 7005
IGLV1-44 6955
CD79B 6766
IGHV4-39 6380
IGLV1-51 6356
IGHD 6047
IGKC 5626
IGLV6-57 5564
IGKV2-30 5333
IGKV1-17 5325
IGKV2D-28 5274
IGHV3-53 4652
IGHV3-11 4632
IGLV1-47 4506
IGKV3-20 4353
IGHV3-23 3995
IGLC1 3875
IGHV3-30 3742
IGKV3D-20 3608
IGHV3-48 2951
IGKV1-33 2779
LYN 781
IGKV4-1 600
IGLV7-43 -281
IGHV1-2 -358
IGLV2-14 -871
IGLV2-23 -1509
IGLV3-27 -1560
IGLV3-21 -1707
IGKV1-16 -3102
IGLV2-11 -5318


Diseases of branched-chain amino acid catabolism
set Diseases of branched-chain amino acid catabolism
setSize 13
pANOVA 0.00132
s.dist -0.514
p.adjustANOVA 0.0149


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBT -9819
AUH -9676
MCCC1 -9053
HIBCH -8808
BCKDHB -7262
MCCC2 -6836
IVD -6563
ECHS1 -5098
BCKDHA -4967
DLD -2375
ACAT1 -1559
PPM1K -6
BCKDK 6544

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBT -9819
AUH -9676
MCCC1 -9053
HIBCH -8808
BCKDHB -7262
MCCC2 -6836
IVD -6563
ECHS1 -5098
BCKDHA -4967
DLD -2375
ACAT1 -1559
PPM1K -6
BCKDK 6544


Repression of WNT target genes
set Repression of WNT target genes
setSize 14
pANOVA 0.000892
s.dist 0.513
p.adjustANOVA 0.0113


Top enriched genes
Top 20 genes
GeneID Gene Rank
TLE3 10917
MYC 10538
TCF7L2 9898
CTBP1 9637
TLE1 9566
TCF7L1 8354
LEF1 6108
CTBP2 5162
TCF7 4438
TLE5 3585
AXIN2 2213
TLE4 1830
HDAC1 1446
TLE2 -1502

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLE3 10917
MYC 10538
TCF7L2 9898
CTBP1 9637
TLE1 9566
TCF7L1 8354
LEF1 6108
CTBP2 5162
TCF7 4438
TLE5 3585
AXIN2 2213
TLE4 1830
HDAC1 1446
TLE2 -1502


RUNX3 regulates WNT signaling
set RUNX3 regulates WNT signaling
setSize 8
pANOVA 0.0125
s.dist 0.51
p.adjustANOVA 0.0783


Top enriched genes
Top 20 genes
GeneID Gene Rank
MYC 10538
TCF7L2 9898
TCF7L1 8354
RUNX3 7466
LEF1 6108
TCF7 4438
CCND1 4184
CTNNB1 -4235

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYC 10538
TCF7L2 9898
TCF7L1 8354
RUNX3 7466
LEF1 6108
TCF7 4438
CCND1 4184
CTNNB1 -4235


Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
set Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
setSize 6
pANOVA 0.0308
s.dist 0.509
p.adjustANOVA 0.14


Top enriched genes
Top 20 genes
GeneID Gene Rank
MYC 10538
H19 10281
ACTB 7866
IGF2BP3 7113
IGF2BP2 1861
CD44 -2649

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYC 10538
H19 10281
ACTB 7866
IGF2BP3 7113
IGF2BP2 1861
CD44 -2649


Anchoring fibril formation
set Anchoring fibril formation
setSize 7
pANOVA 0.0199
s.dist 0.508
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
LAMB3 9745
BMP1 9435
COL4A3 8770
COL4A4 8371
COL4A5 7783
COL4A2 830
COL7A1 -4171

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LAMB3 9745
BMP1 9435
COL4A3 8770
COL4A4 8371
COL4A5 7783
COL4A2 830
COL7A1 -4171


Integration of provirus
set Integration of provirus
setSize 9
pANOVA 0.0084
s.dist -0.507
p.adjustANOVA 0.0592


Top enriched genes
Top 20 genes
GeneID Gene Rank
PSIP1 -9375
KPNA1 -8487
XRCC4 -8232
XRCC5 -8157
XRCC6 -6271
PPIA -5127
LIG4 -4672
BANF1 328
HMGA1 5319

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSIP1 -9375
KPNA1 -8487
XRCC4 -8232
XRCC5 -8157
XRCC6 -6271
PPIA -5127
LIG4 -4672
BANF1 328
HMGA1 5319


Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
set Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
setSize 7
pANOVA 0.0208
s.dist 0.505
p.adjustANOVA 0.112


Top enriched genes
Top 20 genes
GeneID Gene Rank
GAS6 11023
FURIN 10607
PROC 6884
PROZ 6064
BGLAP 4398
PROS1 1450
GGCX 78

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GAS6 11023
FURIN 10607
PROC 6884
PROZ 6064
BGLAP 4398
PROS1 1450
GGCX 78


Activation of caspases through apoptosome-mediated cleavage
set Activation of caspases through apoptosome-mediated cleavage
setSize 6
pANOVA 0.0323
s.dist -0.505
p.adjustANOVA 0.144


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
CASP9 1939

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
CASP9 1939


Synthesis of PIPs at the late endosome membrane
set Synthesis of PIPs at the late endosome membrane
setSize 11
pANOVA 0.00389
s.dist -0.503
p.adjustANOVA 0.034


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIK3C3 -9911
MTMR2 -9343
PIK3C2A -8823
FIG4 -8202
MTM1 -8087
MTMR7 -7833
MTMR9 -7437
PIKFYVE -4312
PIK3R4 -731
MTMR4 1992
VAC14 8633

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3C3 -9911
MTMR2 -9343
PIK3C2A -8823
FIG4 -8202
MTM1 -8087
MTMR7 -7833
MTMR9 -7437
PIKFYVE -4312
PIK3R4 -731
MTMR4 1992
VAC14 8633


Synthesis of PI
set Synthesis of PI
setSize 5
pANOVA 0.0525
s.dist 0.501
p.adjustANOVA 0.199


Top enriched genes
Top 20 genes
GeneID Gene Rank
PITPNM2 10390
PITPNM3 9080
PITPNM1 8803
CDS1 624
CDIPT -171

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PITPNM2 10390
PITPNM3 9080
PITPNM1 8803
CDS1 624
CDIPT -171


H139Hfs13* PPM1K causes a mild variant of MSUD
set H139Hfs13* PPM1K causes a mild variant of MSUD
setSize 5
pANOVA 0.0529
s.dist -0.5
p.adjustANOVA 0.199


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBT -9819
BCKDHB -7262
BCKDHA -4967
DLD -2375
PPM1K -6

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBT -9819
BCKDHB -7262
BCKDHA -4967
DLD -2375
PPM1K -6


Maple Syrup Urine Disease
set Maple Syrup Urine Disease
setSize 5
pANOVA 0.0529
s.dist -0.5
p.adjustANOVA 0.199


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBT -9819
BCKDHB -7262
BCKDHA -4967
DLD -2375
PPM1K -6

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBT -9819
BCKDHB -7262
BCKDHA -4967
DLD -2375
PPM1K -6


Alpha-oxidation of phytanate
set Alpha-oxidation of phytanate
setSize 6
pANOVA 0.0353
s.dist -0.496
p.adjustANOVA 0.151


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALDH3A2 -10047
HACL1 -9772
PHYH -4659
SLC25A17 -3580
SLC27A2 -2760
PECR 1734

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALDH3A2 -10047
HACL1 -9772
PHYH -4659
SLC25A17 -3580
SLC27A2 -2760
PECR 1734


Formation of xylulose-5-phosphate
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.0547
s.dist -0.496
p.adjustANOVA 0.204


Top enriched genes
Top 20 genes
GeneID Gene Rank
XYLB -8325
SORD -5333
CRYL1 -4804
AKR1A1 -3505
DCXR -2264

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
XYLB -8325
SORD -5333
CRYL1 -4804
AKR1A1 -3505
DCXR -2264


Synthesis of Leukotrienes (LT) and Eoxins (EX)
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 15
pANOVA 0.000914
s.dist 0.494
p.adjustANOVA 0.0114


Top enriched genes
Top 20 genes
GeneID Gene Rank
ALOX5 10882
PTGR1 10748
GGT1 10189
CYP4F22 8848
ABCC1 8609
MAPKAPK2 8333
CYP4F3 7867
LTC4S 6988
GGT5 6910
ALOX5AP 5102
LTA4H 5019
ALOX15 4009
CYP4F2 2715
CYP4F8 -1677
DPEP2 -9414

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALOX5 10882
PTGR1 10748
GGT1 10189
CYP4F22 8848
ABCC1 8609
MAPKAPK2 8333
CYP4F3 7867
LTC4S 6988
GGT5 6910
ALOX5AP 5102
LTA4H 5019
ALOX15 4009
CYP4F2 2715
CYP4F8 -1677
DPEP2 -9414


SMAC (DIABLO) binds to IAPs
set SMAC (DIABLO) binds to IAPs
setSize 7
pANOVA 0.0255
s.dist -0.488
p.adjustANOVA 0.124


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
DIABLO -3681
CASP9 1939

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
DIABLO -3681
CASP9 1939


SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
set SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
setSize 7
pANOVA 0.0255
s.dist -0.488
p.adjustANOVA 0.124


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
DIABLO -3681
CASP9 1939

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
DIABLO -3681
CASP9 1939


SMAC, XIAP-regulated apoptotic response
set SMAC, XIAP-regulated apoptotic response
setSize 7
pANOVA 0.0255
s.dist -0.488
p.adjustANOVA 0.124


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
DIABLO -3681
CASP9 1939

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP7 -9735
CASP3 -6461
APAF1 -6190
XIAP -5169
CYCS -3992
DIABLO -3681
CASP9 1939


Phosphate bond hydrolysis by NUDT proteins
set Phosphate bond hydrolysis by NUDT proteins
setSize 7
pANOVA 0.0256
s.dist -0.487
p.adjustANOVA 0.124


Top enriched genes
Top 20 genes
GeneID Gene Rank
NUDT15 -9782
ADPRM -8149
NUDT5 -7589
NUDT16 -3493
NUDT1 -2130
NUDT9 -1887
NUDT18 -234

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUDT15 -9782
ADPRM -8149
NUDT5 -7589
NUDT16 -3493
NUDT1 -2130
NUDT9 -1887
NUDT18 -234


Binding of TCF/LEF:CTNNB1 to target gene promoters
set Binding of TCF/LEF:CTNNB1 to target gene promoters
setSize 8
pANOVA 0.0171
s.dist 0.487
p.adjustANOVA 0.0988


Top enriched genes
Top 20 genes
GeneID Gene Rank
MYC 10538
TCF7L2 9898
TCF7L1 8354
RUNX3 7466
LEF1 6108
TCF7 4438
AXIN2 2213
CTNNB1 -4235

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYC 10538
TCF7L2 9898
TCF7L1 8354
RUNX3 7466
LEF1 6108
TCF7 4438
AXIN2 2213
CTNNB1 -4235


Heme degradation
set Heme degradation
setSize 10
pANOVA 0.00778
s.dist 0.486
p.adjustANOVA 0.056


Top enriched genes
Top 20 genes
GeneID Gene Rank
HMOX1 10404
ABCG2 9381
ABCC1 8609
ABCC2 8459
UGT1A1 7235
BLVRB 6328
SLCO2B1 6310
GUSB 2374
HMOX2 1299
BLVRA -4527

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HMOX1 10404
ABCG2 9381
ABCC1 8609
ABCC2 8459
UGT1A1 7235
BLVRB 6328
SLCO2B1 6310
GUSB 2374
HMOX2 1299
BLVRA -4527


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report