Mitch Report

date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-1.8296535
A1BG	-1.6816671
A1BG-AS1	-0.1542764
A1CF	1.0483644
A2M	1.7385426
A2M-AS1	0.9893933

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2725
num_genes_in_profile	21870
duplicated_genes_present	0
num_profile_genes_in_sets	8802
num_profile_genes_not_in_sets	13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1189
num_genesets_included	1536

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Modulation by Mtb of host immune system	7	1.74e-04	-0.819	9.46e-04
Peptide chain elongation	87	1.13e-39	-0.816	1.08e-37
Maturation of spike protein 9683686	5	1.77e-03	-0.807	7.15e-03
Viral mRNA Translation	87	9.11e-39	-0.806	7.98e-37
Formation of ATP by chemiosmotic coupling	20	6.05e-10	-0.799	7.88e-09
Eukaryotic Translation Elongation	92	5.11e-40	-0.797	5.19e-38
Formation of a pool of free 40S subunits	99	7.17e-42	-0.787	9.21e-40
SARS-CoV-1 modulates host translation machinery	36	3.17e-16	-0.786	8.47e-15
Eukaryotic Translation Termination	91	3.33e-38	-0.782	2.68e-36
Glycosphingolipid transport	7	4.07e-04	-0.772	2.04e-03
Selenocysteine synthesis	91	8.71e-37	-0.767	6.21e-35
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	2.12e-37	-0.765	1.57e-35
Sulfide oxidation to sulfate	5	3.28e-03	-0.759	1.21e-02
SRP-dependent cotranslational protein targeting to membrane	110	6.10e-43	-0.757	9.79e-41
L13a-mediated translational silencing of Ceruloplasmin expression	109	5.48e-42	-0.751	7.54e-40
Formation of annular gap junctions	10	4.28e-05	-0.747	2.57e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	110	8.08e-41	-0.737	8.65e-39
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	4.84e-03	-0.728	1.64e-02
Phosphate bond hydrolysis by NUDT proteins	7	9.24e-04	-0.723	4.08e-03
Cap-dependent Translation Initiation	117	1.23e-41	-0.722	1.39e-39
Eukaryotic Translation Initiation	117	1.23e-41	-0.722	1.39e-39
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	1.99e-35	-0.721	1.28e-33
Formation of the ternary complex, and subsequently, the 43S complex	51	4.30e-18	-0.701	1.36e-16
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.07e-19	-0.683	3.98e-18
Translation initiation complex formation	58	3.54e-19	-0.679	1.22e-17
Ribosomal scanning and start codon recognition	58	8.85e-19	-0.671	2.94e-17
SUMO is conjugated to E1 (UBA2:SAE1)	5	9.60e-03	-0.669	2.86e-02
Fructose metabolism	7	2.23e-03	-0.667	8.79e-03
Selenoamino acid metabolism	114	9.64e-35	-0.665	5.99e-33
Prevention of phagosomal-lysosomal fusion	9	5.89e-04	-0.661	2.78e-03
VLDLR internalisation and degradation	15	9.51e-06	-0.660	6.30e-05
Nef Mediated CD4 Down-regulation	9	6.76e-04	-0.654	3.16e-03
Abacavir ADME	5	1.16e-02	0.652	3.34e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.21e-02	-0.648	3.43e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	7.77e-04	-0.647	3.52e-03
Regulation of expression of SLITs and ROBOs	148	3.67e-42	-0.647	5.44e-40
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.24e-02	-0.646	3.49e-02
Formation of xylulose-5-phosphate	5	1.27e-02	-0.643	3.59e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.38e-02	-0.636	3.81e-02
FLT3 signaling by CBL mutants	7	3.56e-03	-0.636	1.28e-02
Pentose phosphate pathway	13	7.55e-05	-0.634	4.36e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	1.22e-30	-0.626	6.05e-29
Nonsense-Mediated Decay (NMD)	113	1.22e-30	-0.626	6.05e-29
Protein repair	6	7.98e-03	-0.625	2.50e-02
Ethanol oxidation	7	4.23e-03	-0.624	1.48e-02
Defective CFTR causes cystic fibrosis	47	1.75e-13	-0.621	3.79e-12
Formyl peptide receptors bind formyl peptides and many other ligands	7	4.58e-03	-0.619	1.57e-02
Josephin domain DUBs	10	7.11e-04	-0.618	3.28e-03
Cellular response to starvation	147	1.11e-37	-0.612	8.55e-36
SARS-CoV-2 modulates host translation machinery	49	1.44e-13	-0.610	3.15e-12

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Modulation by Mtb of host immune system	7	1.74e-04	-0.819000	9.46e-04
Peptide chain elongation	87	1.13e-39	-0.816000	1.08e-37
Maturation of spike protein 9683686	5	1.77e-03	-0.807000	7.15e-03
Viral mRNA Translation	87	9.11e-39	-0.806000	7.98e-37
Formation of ATP by chemiosmotic coupling	20	6.05e-10	-0.799000	7.88e-09
Eukaryotic Translation Elongation	92	5.11e-40	-0.797000	5.19e-38
Formation of a pool of free 40S subunits	99	7.17e-42	-0.787000	9.21e-40
SARS-CoV-1 modulates host translation machinery	36	3.17e-16	-0.786000	8.47e-15
Eukaryotic Translation Termination	91	3.33e-38	-0.782000	2.68e-36
Glycosphingolipid transport	7	4.07e-04	-0.772000	2.04e-03
Selenocysteine synthesis	91	8.71e-37	-0.767000	6.21e-35
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	2.12e-37	-0.765000	1.57e-35
Sulfide oxidation to sulfate	5	3.28e-03	-0.759000	1.21e-02
SRP-dependent cotranslational protein targeting to membrane	110	6.10e-43	-0.757000	9.79e-41
L13a-mediated translational silencing of Ceruloplasmin expression	109	5.48e-42	-0.751000	7.54e-40
Formation of annular gap junctions	10	4.28e-05	-0.747000	2.57e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	110	8.08e-41	-0.737000	8.65e-39
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	4.84e-03	-0.728000	1.64e-02
Phosphate bond hydrolysis by NUDT proteins	7	9.24e-04	-0.723000	4.08e-03
Cap-dependent Translation Initiation	117	1.23e-41	-0.722000	1.39e-39
Eukaryotic Translation Initiation	117	1.23e-41	-0.722000	1.39e-39
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	1.99e-35	-0.721000	1.28e-33
Formation of the ternary complex, and subsequently, the 43S complex	51	4.30e-18	-0.701000	1.36e-16
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.07e-19	-0.683000	3.98e-18
Translation initiation complex formation	58	3.54e-19	-0.679000	1.22e-17
Ribosomal scanning and start codon recognition	58	8.85e-19	-0.671000	2.94e-17
SUMO is conjugated to E1 (UBA2:SAE1)	5	9.60e-03	-0.669000	2.86e-02
Fructose metabolism	7	2.23e-03	-0.667000	8.79e-03
Selenoamino acid metabolism	114	9.64e-35	-0.665000	5.99e-33
Prevention of phagosomal-lysosomal fusion	9	5.89e-04	-0.661000	2.78e-03
VLDLR internalisation and degradation	15	9.51e-06	-0.660000	6.30e-05
Nef Mediated CD4 Down-regulation	9	6.76e-04	-0.654000	3.16e-03
Abacavir ADME	5	1.16e-02	0.652000	3.34e-02
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.21e-02	-0.648000	3.43e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	7.77e-04	-0.647000	3.52e-03
Regulation of expression of SLITs and ROBOs	148	3.67e-42	-0.647000	5.44e-40
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.24e-02	-0.646000	3.49e-02
Formation of xylulose-5-phosphate	5	1.27e-02	-0.643000	3.59e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.38e-02	-0.636000	3.81e-02
FLT3 signaling by CBL mutants	7	3.56e-03	-0.636000	1.28e-02
Pentose phosphate pathway	13	7.55e-05	-0.634000	4.36e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	1.22e-30	-0.626000	6.05e-29
Nonsense-Mediated Decay (NMD)	113	1.22e-30	-0.626000	6.05e-29
Protein repair	6	7.98e-03	-0.625000	2.50e-02
Ethanol oxidation	7	4.23e-03	-0.624000	1.48e-02
Defective CFTR causes cystic fibrosis	47	1.75e-13	-0.621000	3.79e-12
Formyl peptide receptors bind formyl peptides and many other ligands	7	4.58e-03	-0.619000	1.57e-02
Josephin domain DUBs	10	7.11e-04	-0.618000	3.28e-03
Cellular response to starvation	147	1.11e-37	-0.612000	8.55e-36
SARS-CoV-2 modulates host translation machinery	49	1.44e-13	-0.610000	3.15e-12
Hh mutants are degraded by ERAD	42	9.39e-12	-0.607000	1.77e-10
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	2.05e-10	-0.604000	3.04e-09
Regulation of ornithine decarboxylase (ODC)	38	1.18e-10	-0.604000	1.86e-09
Gap junction degradation	11	5.56e-04	-0.601000	2.63e-03
Vif-mediated degradation of APOBEC3G	41	3.15e-11	-0.599000	5.38e-10
Hh mutants abrogate ligand secretion	43	1.18e-11	-0.597000	2.17e-10
GDP-fucose biosynthesis	6	1.13e-02	-0.597000	3.27e-02
Retrograde neurotrophin signalling	12	3.66e-04	-0.594000	1.86e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	1.46e-10	-0.593000	2.23e-09
p53-Independent DNA Damage Response	39	1.46e-10	-0.593000	2.23e-09
p53-Independent G1/S DNA damage checkpoint	39	1.46e-10	-0.593000	2.23e-09
Vpu mediated degradation of CD4	39	1.63e-10	-0.591000	2.45e-09
Influenza Viral RNA Transcription and Replication	134	4.79e-32	-0.589000	2.64e-30
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	1.25e-02	-0.588000	3.54e-02
Pyrimidine salvage	10	1.31e-03	-0.587000	5.55e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	4.66e-11	-0.587000	7.61e-10
Nef Mediated CD8 Down-regulation	7	7.46e-03	-0.584000	2.37e-02
p75NTR recruits signalling complexes	12	4.61e-04	-0.584000	2.25e-03
Cross-presentation of soluble exogenous antigens (endosomes)	35	2.23e-09	-0.584000	2.57e-08
Metabolism of polyamines	46	7.66e-12	-0.583000	1.48e-10
Cristae formation	33	6.76e-09	-0.583000	7.12e-08
CS/DS degradation	9	2.56e-03	-0.580000	9.87e-03
Autodegradation of the E3 ubiquitin ligase COP1	38	5.98e-10	-0.580000	7.84e-09
Classical antibody-mediated complement activation	70	4.54e-17	-0.580000	1.35e-15
Sema4D mediated inhibition of cell attachment and migration	7	7.88e-03	-0.580000	2.48e-02
Ubiquitin-dependent degradation of Cyclin D	39	3.80e-10	-0.579000	5.30e-09
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	4.72e-03	-0.577000	1.60e-02
Negative regulation of NOTCH4 signaling	44	3.68e-11	-0.576000	6.11e-10
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.04e-03	-0.571000	4.48e-03
Translation	292	1.38e-63	-0.571000	8.84e-61
Mitochondrial translation elongation	90	8.29e-21	-0.570000	3.40e-19
Fructose catabolism	5	2.73e-02	-0.570000	6.62e-02
Hedgehog ligand biogenesis	47	1.44e-11	-0.569000	2.62e-10
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	9.14e-03	-0.569000	2.75e-02
FLT3 signaling through SRC family kinases	6	1.59e-02	-0.568000	4.29e-02
Activation of RAC1 downstream of NMDARs	7	9.39e-03	-0.567000	2.81e-02
Degradation of DVL	43	1.49e-10	-0.564000	2.25e-09
Protein hydroxylation	17	5.72e-05	-0.564000	3.38e-04
Creation of C4 and C2 activators	72	1.29e-16	-0.564000	3.60e-15
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	4.37e-10	-0.563000	5.88e-09
p75NTR negatively regulates cell cycle via SC1	5	2.96e-02	-0.562000	7.08e-02
WNT5A-dependent internalization of FZD4	13	4.70e-04	-0.560000	2.27e-03
Citric acid cycle (TCA cycle)	34	2.11e-08	-0.555000	2.06e-07
Asymmetric localization of PCP proteins	49	1.97e-11	-0.554000	3.51e-10
Advanced glycosylation endproduct receptor signaling	12	9.06e-04	-0.553000	4.02e-03
Signaling by ROBO receptors	188	5.70e-39	-0.551000	5.23e-37
Mitochondrial protein import	63	4.04e-14	-0.550000	9.26e-13
Regulation of Apoptosis	40	1.83e-09	-0.549000	2.14e-08
Mitochondrial translation initiation	90	2.75e-19	-0.547000	9.65e-18
SCF-beta-TrCP mediated degradation of Emi1	42	1.07e-09	-0.544000	1.33e-08
Scavenging of heme from plasma	71	3.09e-15	-0.541000	7.45e-14
Influenza Infection	153	6.70e-31	-0.541000	3.49e-29
Negative feedback regulation of MAPK pathway	6	2.19e-02	-0.540000	5.58e-02
Mitochondrial translation termination	90	1.88e-18	-0.534000	6.15e-17
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	3.87e-02	-0.534000	8.73e-02
Glyoxylate metabolism and glycine degradation	13	8.61e-04	-0.534000	3.84e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	2.46e-09	-0.532000	2.79e-08
Abortive elongation of HIV-1 transcript in the absence of Tat	23	1.14e-05	-0.529000	7.47e-05
Degradation of GLI2 by the proteasome	45	8.90e-10	-0.528000	1.14e-08
Complex III assembly	23	1.20e-05	-0.527000	7.82e-05
Complex I biogenesis	66	1.36e-13	-0.526000	3.02e-12
Hyaluronan uptake and degradation	12	1.62e-03	-0.525000	6.68e-03
Initial triggering of complement	80	4.76e-16	-0.525000	1.22e-14
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	2.61e-02	-0.524000	6.39e-02
Aryl hydrocarbon receptor signalling	6	2.64e-02	-0.523000	6.42e-02
Respiratory electron transport	149	2.56e-28	-0.523000	1.24e-26
GLI3 is processed to GLI3R by the proteasome	46	1.02e-09	-0.520000	1.29e-08
FCGR activation	77	2.94e-15	-0.520000	7.16e-14
RNA Polymerase I Promoter Opening	17	2.12e-04	-0.519000	1.12e-03
NF-kB is activated and signals survival	12	1.92e-03	-0.517000	7.72e-03
CD22 mediated BCR regulation	59	8.00e-12	-0.514000	1.53e-10
Maturation of TCA enzymes and regulation of TCA cycle	20	7.00e-05	-0.513000	4.07e-04
Mitochondrial translation	96	3.27e-18	-0.513000	1.05e-16
Degradation of AXIN	42	8.57e-09	-0.513000	8.93e-08
Dermatan sulfate biosynthesis	6	2.97e-02	-0.512000	7.08e-02
Pausing and recovery of Tat-mediated HIV elongation	30	1.27e-06	-0.511000	9.44e-06
Tat-mediated HIV elongation arrest and recovery	30	1.27e-06	-0.511000	9.44e-06
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	4.09e-04	-0.510000	2.04e-03
Miscellaneous substrates	8	1.26e-02	0.510000	3.54e-02
Spry regulation of FGF signaling	16	4.30e-04	-0.508000	2.11e-03
Beta-oxidation of pristanoyl-CoA	9	8.26e-03	-0.508000	2.57e-02
Gluconeogenesis	19	1.30e-04	-0.507000	7.18e-04
Mitochondrial calcium ion transport	22	3.83e-05	-0.507000	2.32e-04
Major pathway of rRNA processing in the nucleolus and cytosol	179	1.04e-31	-0.507000	5.55e-30
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	2.17e-07	-0.506000	1.77e-06
Regulation of RUNX3 expression and activity	45	4.19e-09	-0.506000	4.54e-08
rRNA processing in the nucleus and cytosol	189	2.99e-33	-0.506000	1.69e-31
Synthesis of GDP-mannose	6	3.23e-02	-0.505000	7.62e-02
Proteasome assembly	51	4.82e-10	-0.504000	6.40e-09
Complex IV assembly	45	5.14e-09	-0.503000	5.47e-08
Assembly Of The HIV Virion	15	7.57e-04	-0.502000	3.44e-03
Phenylalanine metabolism	5	5.25e-02	-0.501000	1.13e-01
Degradation of cysteine and homocysteine	12	2.75e-03	-0.499000	1.04e-02
Role of LAT2/NTAL/LAB on calcium mobilization	78	2.53e-14	-0.499000	5.87e-13
DNA methylation	18	2.71e-04	-0.496000	1.41e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	5.74e-05	-0.495000	3.38e-04
Stabilization of p53	43	1.91e-08	-0.495000	1.88e-07
Folding of actin by CCT/TriC	10	7.21e-03	-0.491000	2.32e-02
Metabolism of folate and pterines	16	7.03e-04	-0.489000	3.25e-03
IRE1alpha activates chaperones	46	1.02e-08	-0.488000	1.05e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	1.16e-09	-0.488000	1.43e-08
Dectin-1 mediated noncanonical NF-kB signaling	48	5.54e-09	-0.486000	5.87e-08
Suppression of phagosomal maturation	12	3.54e-03	-0.486000	1.28e-02
NIK–>noncanonical NF-kB signaling	46	1.17e-08	-0.486000	1.19e-07
Pexophagy	10	7.82e-03	-0.486000	2.47e-02
PCP/CE pathway	75	3.69e-13	-0.485000	7.81e-12
MASTL Facilitates Mitotic Progression	10	7.94e-03	-0.485000	2.49e-02
rRNA processing	213	2.59e-34	-0.485000	1.56e-32
Degradation of GLI1 by the proteasome	46	1.31e-08	-0.484000	1.33e-07
XBP1(S) activates chaperone genes	44	2.85e-08	-0.483000	2.74e-07
APC/C:Cdc20 mediated degradation of Securin	55	6.24e-10	-0.482000	8.07e-09
Aerobic respiration and respiratory electron transport	245	1.18e-38	-0.481000	9.89e-37
Mitochondrial protein degradation	96	3.80e-16	-0.481000	1.00e-14
The role of GTSE1 in G2/M progression after G2 checkpoint	59	1.73e-10	-0.480000	2.58e-09
Calnexin/calreticulin cycle	26	2.31e-05	-0.480000	1.44e-04
Autodegradation of Cdh1 by Cdh1:APC/C	54	1.22e-09	-0.478000	1.49e-08
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	9.40e-04	-0.478000	4.13e-03
RHOBTB3 ATPase cycle	10	9.14e-03	-0.476000	2.75e-02
Somitogenesis	41	1.38e-07	-0.475000	1.18e-06
Prostanoid ligand receptors	8	2.03e-02	-0.474000	5.24e-02
Replacement of protamines by nucleosomes in the male pronucleus	13	3.11e-03	-0.473000	1.16e-02
Fatty acids	8	2.07e-02	0.472000	5.32e-02
Maturation of spike protein 9694548	36	9.45e-07	-0.472000	7.23e-06
Synthesis of Dolichyl-phosphate	6	4.54e-02	-0.472000	9.99e-02
ER-Phagosome pathway	75	1.61e-12	-0.472000	3.23e-11
Glycogen synthesis	11	6.78e-03	-0.471000	2.21e-02
Mucopolysaccharidoses	11	6.79e-03	-0.471000	2.21e-02
Cellular response to hypoxia	59	3.74e-10	-0.471000	5.26e-09
Regulation of RAS by GAPs	55	1.49e-09	-0.471000	1.77e-08
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	11	6.89e-03	-0.470000	2.23e-02
Defective EXT2 causes exostoses 2	11	6.89e-03	-0.470000	2.23e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	1.93e-04	-0.470000	1.04e-03
Inhibition of DNA recombination at telomere	33	2.98e-06	-0.470000	2.17e-05
Expression and translocation of olfactory receptors	52	4.58e-09	0.470000	4.93e-08
ERKs are inactivated	13	3.38e-03	-0.469000	1.23e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	7.35e-03	-0.467000	2.35e-02
PDH complex synthesizes acetyl-CoA from PYR	5	7.08e-02	-0.467000	1.43e-01
FCERI mediated NF-kB activation	130	4.20e-20	-0.466000	1.62e-18
p75NTR signals via NF-kB	15	1.82e-03	-0.465000	7.35e-03
Glutamate and glutamine metabolism	12	5.31e-03	-0.465000	1.77e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	12	5.33e-03	-0.465000	1.78e-02
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	7.39e-02	-0.462000	1.48e-01
SLBP independent Processing of Histone Pre-mRNAs	10	1.16e-02	-0.461000	3.34e-02
Malate-aspartate shuttle	8	2.41e-02	-0.461000	6.02e-02
Diseases of carbohydrate metabolism	29	1.79e-05	-0.460000	1.15e-04
Packaging Of Telomere Ends	18	7.24e-04	-0.460000	3.32e-03
Binding and Uptake of Ligands by Scavenger Receptors	93	1.82e-14	-0.459000	4.28e-13
The NLRP3 inflammasome	16	1.48e-03	-0.459000	6.16e-03
G2/M DNA replication checkpoint	5	7.56e-02	-0.459000	1.51e-01
Membrane binding and targetting of GAG proteins	13	4.37e-03	-0.456000	1.51e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	4.37e-03	-0.456000	1.51e-02
Infection with Mycobacterium tuberculosis	26	5.81e-05	-0.455000	3.40e-04
ABC transporter disorders	60	1.12e-09	-0.454000	1.38e-08
HIV elongation arrest and recovery	32	8.61e-06	-0.454000	5.72e-05
Pausing and recovery of HIV elongation	32	8.61e-06	-0.454000	5.72e-05
Zinc influx into cells by the SLC39 gene family	9	1.84e-02	-0.454000	4.84e-02
A tetrasaccharide linker sequence is required for GAG synthesis	18	9.21e-04	-0.451000	4.08e-03
Chondroitin sulfate/dermatan sulfate metabolism	39	1.18e-06	-0.450000	8.88e-06
Glycosphingolipid catabolism	31	1.54e-05	-0.449000	9.91e-05
SCF(Skp2)-mediated degradation of p27/p21	50	4.76e-08	-0.446000	4.35e-07
Role of phospholipids in phagocytosis	89	3.96e-13	-0.445000	8.29e-12
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	2.50e-09	-0.445000	2.82e-08
TGFBR3 PTM regulation	10	1.49e-02	-0.444000	4.04e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	1.94e-09	-0.444000	2.25e-08
Signal attenuation	9	2.13e-02	-0.443000	5.45e-02
LDL clearance	17	1.60e-03	-0.442000	6.60e-03
CDK-mediated phosphorylation and removal of Cdc6	60	3.19e-09	-0.442000	3.55e-08
p53-Dependent G1 DNA Damage Response	52	3.79e-08	-0.441000	3.51e-07
p53-Dependent G1/S DNA damage checkpoint	52	3.79e-08	-0.441000	3.51e-07
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	2.48e-10	-0.440000	3.59e-09
mTORC1-mediated signalling	24	1.88e-04	-0.440000	1.01e-03
Regulation of PTEN stability and activity	55	1.63e-08	-0.440000	1.62e-07
Defective B4GALT7 causes EDS, progeroid type	12	8.35e-03	-0.440000	2.58e-02
FCGR3A-mediated phagocytosis	122	5.09e-17	-0.439000	1.44e-15
Leishmania phagocytosis	122	5.09e-17	-0.439000	1.44e-15
Parasite infection	122	5.09e-17	-0.439000	1.44e-15
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	1.18e-02	-0.439000	3.37e-02
Tandem pore domain potassium channels	5	8.97e-02	-0.438000	1.72e-01
G1/S DNA Damage Checkpoints	54	2.58e-08	-0.438000	2.48e-07
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	1.48e-09	-0.437000	1.77e-08
Lysosome Vesicle Biogenesis	32	1.93e-05	-0.436000	1.23e-04
Interconversion of nucleotide di- and triphosphates	27	8.67e-05	-0.436000	4.96e-04
Platelet sensitization by LDL	16	2.54e-03	-0.436000	9.81e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	4.14e-09	-0.435000	4.50e-08
APC/C:Cdc20 mediated degradation of mitotic proteins	63	2.32e-09	-0.435000	2.64e-08
Regulation of RUNX2 expression and activity	54	3.19e-08	-0.435000	3.03e-07
Prefoldin mediated transfer of substrate to CCT/TriC	25	1.69e-04	-0.435000	9.21e-04
Orc1 removal from chromatin	58	1.47e-08	-0.430000	1.48e-07
Hyaluronan metabolism	15	4.03e-03	-0.429000	1.43e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	6.89e-02	-0.429000	1.41e-01
Cleavage of the damaged purine	22	5.00e-04	-0.429000	2.38e-03
Depurination	22	5.00e-04	-0.429000	2.38e-03
Recognition and association of DNA glycosylase with site containing an affected purine	22	5.00e-04	-0.429000	2.38e-03
Processing of SMDT1	15	4.07e-03	-0.428000	1.43e-02
Formation of the Early Elongation Complex	33	2.07e-05	-0.428000	1.31e-04
Formation of the HIV-1 Early Elongation Complex	33	2.07e-05	-0.428000	1.31e-04
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	9.39e-08	-0.428000	8.15e-07
Regulation of actin dynamics for phagocytic cup formation	124	1.94e-16	-0.427000	5.33e-15
Killing mechanisms	10	1.95e-02	-0.427000	5.07e-02
WNT5:FZD7-mediated leishmania damping	10	1.95e-02	-0.427000	5.07e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	1.44e-02	-0.426000	3.94e-02
Defective B3GAT3 causes JDSSDHD	12	1.06e-02	-0.426000	3.13e-02
Degradation of beta-catenin by the destruction complex	72	4.06e-10	-0.426000	5.63e-09
Plasma lipoprotein clearance	32	3.06e-05	-0.426000	1.88e-04
Activation of NF-kappaB in B cells	54	7.06e-08	-0.424000	6.27e-07
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	5.24e-02	-0.423000	1.13e-01
Chondroitin sulfate biosynthesis	12	1.11e-02	-0.423000	3.25e-02
Activation of NOXA and translocation to mitochondria	5	1.02e-01	-0.423000	1.91e-01
Protein localization	157	6.28e-20	-0.422000	2.37e-18
FCERI mediated MAPK activation	94	1.49e-12	-0.422000	3.01e-11
ATF6 (ATF6-alpha) activates chaperones	12	1.15e-02	-0.421000	3.31e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	2.11e-02	-0.421000	5.41e-02
Erythrocytes take up oxygen and release carbon dioxide	7	5.38e-02	0.421000	1.15e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	1.18e-04	-0.420000	6.59e-04
Metabolism of amino acids and derivatives	305	1.78e-36	-0.419000	1.22e-34
Nuclear events mediated by NFE2L2	82	5.47e-11	-0.419000	8.86e-10
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	1.26e-04	-0.419000	6.98e-04
Noncanonical activation of NOTCH3	8	4.07e-02	-0.418000	9.11e-02
Frs2-mediated activation	11	1.65e-02	-0.418000	4.38e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	1.30e-04	-0.418000	7.18e-04
Response of Mtb to phagocytosis	22	6.96e-04	-0.418000	3.24e-03
Signaling by NOTCH4	68	2.67e-09	-0.417000	2.99e-08
Arachidonate production from DAG	5	1.07e-01	-0.417000	1.99e-01
Purine catabolism	16	3.96e-03	-0.416000	1.41e-02
FCGR3A-mediated IL10 synthesis	100	7.60e-13	-0.415000	1.57e-11
Nef mediated downregulation of MHC class I complex cell surface expression	10	2.32e-02	-0.415000	5.85e-02
Regulation of APC/C activators between G1/S and early anaphase	68	3.44e-09	-0.414000	3.79e-08
Regulation of Complement cascade	97	1.75e-12	-0.414000	3.48e-11
Myoclonic epilepsy of Lafora	8	4.31e-02	-0.413000	9.55e-02
UCH proteinases	73	1.07e-09	-0.413000	1.33e-08
Cytosolic sulfonation of small molecules	18	2.47e-03	-0.412000	9.63e-03
Cytosolic iron-sulfur cluster assembly	13	1.01e-02	-0.412000	3.01e-02
Synthesis of pyrophosphates in the cytosol	8	4.48e-02	-0.410000	9.90e-02
Complement cascade	101	1.15e-12	-0.409000	2.36e-11
Antigen processing-Cross presentation	89	2.56e-11	-0.409000	4.48e-10
NRIF signals cell death from the nucleus	15	6.11e-03	-0.409000	2.00e-02
Methionine salvage pathway	6	8.30e-02	-0.409000	1.63e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	2.52e-02	-0.409000	6.22e-02
Ubiquinol biosynthesis	13	1.10e-02	-0.407000	3.21e-02
Nucleotide biosynthesis	12	1.48e-02	-0.406000	4.02e-02
Sulfur amino acid metabolism	22	1.01e-03	-0.405000	4.39e-03
Heparan sulfate/heparin (HS-GAG) metabolism	41	7.55e-06	-0.404000	5.09e-05
Golgi Cisternae Pericentriolar Stack Reorganization	14	9.07e-03	-0.403000	2.74e-02
Olfactory Signaling Pathway	57	1.55e-07	0.402000	1.29e-06
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	6.80e-06	-0.401000	4.62e-05
HIV Transcription Elongation	42	6.80e-06	-0.401000	4.62e-05
Tat-mediated elongation of the HIV-1 transcript	42	6.80e-06	-0.401000	4.62e-05
DNA Damage Recognition in GG-NER	38	1.90e-05	-0.401000	1.22e-04
Translation of Structural Proteins 9694635	56	2.13e-07	-0.401000	1.74e-06
RNA Pol II CTD phosphorylation and interaction with CE	27	3.23e-04	-0.400000	1.66e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	3.23e-04	-0.400000	1.66e-03
mRNA Splicing - Minor Pathway	50	1.01e-06	-0.400000	7.67e-06
Regulation of mRNA stability by proteins that bind AU-rich elements	76	1.69e-09	-0.400000	2.00e-08
Late SARS-CoV-2 Infection Events	64	3.31e-08	-0.399000	3.13e-07
Release of apoptotic factors from the mitochondria	6	9.06e-02	-0.399000	1.74e-01
DNA Replication Pre-Initiation	103	2.61e-12	-0.399000	5.08e-11
Formation of paraxial mesoderm	52	7.04e-07	-0.398000	5.51e-06
FCERI mediated Ca+2 mobilization	93	3.48e-11	-0.397000	5.86e-10
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	6.92e-02	-0.397000	1.41e-01
Axonal growth inhibition (RHOA activation)	7	6.92e-02	-0.397000	1.41e-01
p75NTR regulates axonogenesis	7	6.92e-02	-0.397000	1.41e-01
Budding and maturation of HIV virion	26	4.65e-04	-0.396000	2.26e-03
Diseases associated with glycosaminoglycan metabolism	26	4.73e-04	-0.396000	2.27e-03
Beta-catenin phosphorylation cascade	17	4.72e-03	-0.396000	1.60e-02
Inactivation of CSF3 (G-CSF) signaling	24	7.98e-04	-0.395000	3.61e-03
ER Quality Control Compartment (ERQC)	21	1.76e-03	-0.394000	7.12e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	84	4.11e-10	-0.394000	5.64e-09
Assembly of the pre-replicative complex	87	2.15e-10	-0.394000	3.17e-09
Acyl chain remodeling of CL	5	1.29e-01	-0.392000	2.29e-01
Attachment of GPI anchor to uPAR	7	7.31e-02	-0.391000	1.47e-01
Zinc transporters	12	1.90e-02	-0.391000	4.97e-02
RNA Polymerase III Chain Elongation	18	4.11e-03	-0.391000	1.44e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	1.96e-03	-0.390000	7.82e-03
Neurodegenerative Diseases	21	1.96e-03	-0.390000	7.82e-03
N-glycan trimming and elongation in the cis-Golgi	5	1.31e-01	-0.390000	2.31e-01
Metabolism of nucleotides	85	5.33e-10	-0.389000	7.03e-09
Biosynthesis of Lipoxins (LX)	6	1.01e-01	-0.387000	1.90e-01
Induction of Cell-Cell Fusion	8	5.84e-02	-0.386000	1.23e-01
MAPK3 (ERK1) activation	10	3.45e-02	-0.386000	8.02e-02
PINK1-PRKN Mediated Mitophagy	31	2.00e-04	-0.386000	1.06e-03
Phenylalanine and tyrosine metabolism	9	4.51e-02	-0.386000	9.92e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	8.59e-04	-0.385000	3.84e-03
Insulin receptor recycling	24	1.13e-03	-0.384000	4.83e-03
NFE2L2 regulating inflammation associated genes	5	1.38e-01	0.383000	2.42e-01
Fcgamma receptor (FCGR) dependent phagocytosis	148	8.03e-16	-0.383000	2.04e-14
RMTs methylate histone arginines	35	9.06e-05	-0.382000	5.16e-04
Cell recruitment (pro-inflammatory response)	25	9.42e-04	-0.382000	4.13e-03
Purinergic signaling in leishmaniasis infection	25	9.42e-04	-0.382000	4.13e-03
Signal transduction by L1	20	3.10e-03	-0.382000	1.15e-02
Amino acids regulate mTORC1	48	4.79e-06	-0.382000	3.35e-05
RUNX2 regulates genes involved in cell migration	6	1.07e-01	-0.380000	1.99e-01
Phosphorylation of Emi1	6	1.08e-01	-0.379000	2.01e-01
Signaling by the B Cell Receptor (BCR)	151	9.22e-16	-0.379000	2.31e-14
Anti-inflammatory response favouring Leishmania parasite infection	133	5.10e-14	-0.378000	1.14e-12
Leishmania parasite growth and survival	133	5.10e-14	-0.378000	1.14e-12
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	1.44e-01	0.378000	2.47e-01
Condensation of Prophase Chromosomes	27	7.00e-04	-0.377000	3.25e-03
Synthesis of Ketone Bodies	6	1.10e-01	-0.377000	2.04e-01
Signaling by CSF3 (G-CSF)	29	4.47e-04	-0.377000	2.19e-03
Caspase-mediated cleavage of cytoskeletal proteins	12	2.41e-02	-0.376000	6.02e-02
Neutrophil degranulation	456	3.50e-43	-0.376000	6.13e-41
SARS-CoV-1-host interactions	94	3.04e-10	-0.376000	4.37e-09
Signaling by FGFR2 IIIa TM	18	5.85e-03	-0.375000	1.93e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	3.88e-04	-0.374000	1.95e-03
Negative regulation of FLT3	15	1.21e-02	-0.374000	3.43e-02
CTLA4 inhibitory signaling	21	2.99e-03	-0.374000	1.12e-02
Nucleotide salvage	21	3.05e-03	-0.373000	1.14e-02
Activated point mutants of FGFR2	7	8.72e-02	0.373000	1.69e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.94e-03	-0.373000	7.81e-03
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.22e-02	-0.373000	7.62e-02
WNT mediated activation of DVL	8	6.80e-02	-0.373000	1.40e-01
Glycogen storage diseases	13	2.01e-02	-0.372000	5.20e-02
The activation of arylsulfatases	10	4.14e-02	-0.372000	9.25e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	4.15e-04	-0.372000	2.06e-03
IRAK1 recruits IKK complex	14	1.60e-02	-0.372000	4.30e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	1.60e-02	-0.372000	4.30e-02
Purine ribonucleoside monophosphate biosynthesis	9	5.37e-02	-0.371000	1.15e-01
HS-GAG degradation	20	4.07e-03	-0.371000	1.43e-02
Azathioprine ADME	20	4.07e-03	-0.371000	1.43e-02
Mitophagy	38	7.68e-05	-0.371000	4.42e-04
Defective Intrinsic Pathway for Apoptosis	24	1.68e-03	-0.370000	6.84e-03
Displacement of DNA glycosylase by APEX1	9	5.45e-02	-0.370000	1.16e-01
STAT5 Activation	7	9.06e-02	-0.369000	1.74e-01
Amyloid fiber formation	51	5.06e-06	-0.369000	3.52e-05
Late endosomal microautophagy	30	4.67e-04	-0.369000	2.26e-03
Diseases associated with N-glycosylation of proteins	20	4.27e-03	-0.369000	1.48e-02
SARS-CoV-2 modulates autophagy	11	3.49e-02	-0.367000	8.06e-02
Cellular response to chemical stress	179	2.73e-17	-0.366000	8.36e-16
Detoxification of Reactive Oxygen Species	30	5.22e-04	-0.366000	2.48e-03
tRNA processing in the mitochondrion	24	1.96e-03	-0.365000	7.82e-03
Base-Excision Repair, AP Site Formation	29	6.65e-04	-0.365000	3.12e-03
Formation of HIV elongation complex in the absence of HIV Tat	44	2.78e-05	-0.365000	1.72e-04
CTNNB1 S33 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
CTNNB1 S37 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
CTNNB1 S45 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
CTNNB1 T41 mutants aren’t phosphorylated	15	1.44e-02	-0.365000	3.94e-02
Signaling by CTNNB1 phospho-site mutants	15	1.44e-02	-0.365000	3.94e-02
Signaling by GSK3beta mutants	15	1.44e-02	-0.365000	3.94e-02
Synthesis of PG	8	7.42e-02	-0.364000	1.49e-01
Formation of TC-NER Pre-Incision Complex	51	6.83e-06	-0.364000	4.62e-05
Glycogen metabolism	22	3.16e-03	-0.364000	1.17e-02
Activation of BAD and translocation to mitochondria	15	1.48e-02	-0.363000	4.02e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	4.66e-02	-0.363000	1.02e-01
Eicosanoid ligand-binding receptors	13	2.34e-02	-0.363000	5.89e-02
KEAP1-NFE2L2 pathway	107	8.77e-11	-0.363000	1.41e-09
TGFBR3 regulates TGF-beta signaling	8	7.60e-02	-0.362000	1.51e-01
APC/C-mediated degradation of cell cycle proteins	75	5.89e-08	-0.362000	5.33e-07
Regulation of mitotic cell cycle	75	5.89e-08	-0.362000	5.33e-07
Cyclin E associated events during G1/S transition	73	8.89e-08	-0.362000	7.75e-07
HS-GAG biosynthesis	21	4.09e-03	-0.362000	1.44e-02
Pregnenolone biosynthesis	10	4.76e-02	-0.362000	1.03e-01
SUMOylation of DNA methylation proteins	16	1.23e-02	-0.361000	3.48e-02
Ephrin signaling	18	8.34e-03	-0.359000	2.58e-02
Synthesis of PIPs at the late endosome membrane	11	3.93e-02	0.359000	8.83e-02
Host Interactions of HIV factors	118	1.75e-11	-0.358000	3.15e-10
Leishmania infection	213	1.89e-19	-0.358000	6.76e-18
Parasitic Infection Pathways	213	1.89e-19	-0.358000	6.76e-18
Regulation of localization of FOXO transcription factors	12	3.17e-02	-0.358000	7.52e-02
Translation of Structural Proteins 9683701	29	8.46e-04	-0.358000	3.80e-03
mRNA Capping	29	8.85e-04	-0.357000	3.94e-03
2-LTR circle formation	7	1.02e-01	-0.357000	1.92e-01
Downstream signaling events of B Cell Receptor (BCR)	68	3.69e-07	-0.356000	2.96e-06
Switching of origins to a post-replicative state	79	4.30e-08	-0.356000	3.94e-07
Cyclin A:Cdk2-associated events at S phase entry	75	9.97e-08	-0.356000	8.61e-07
Gap junction trafficking	28	1.13e-03	-0.356000	4.83e-03
PTK6 Regulates Cell Cycle	6	1.32e-01	-0.355000	2.33e-01
Fc epsilon receptor (FCERI) signaling	180	2.18e-16	-0.355000	5.92e-15
Estrogen-stimulated signaling through PRKCZ	6	1.34e-01	-0.353000	2.36e-01
Translesion Synthesis by POLH	18	9.50e-03	-0.353000	2.84e-02
Unwinding of DNA	12	3.46e-02	-0.352000	8.02e-02
RNA Polymerase III Transcription Termination	22	4.24e-03	-0.352000	1.48e-02
Biotin transport and metabolism	11	4.34e-02	-0.352000	9.60e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	6.61e-03	-0.351000	2.16e-02
Cytoprotection by HMOX1	53	1.00e-05	-0.351000	6.62e-05
Regulation of TLR by endogenous ligand	15	1.89e-02	-0.350000	4.96e-02
Cell surface interactions at the vascular wall	173	1.89e-15	-0.350000	4.68e-14
Hedgehog ‘on’ state	66	9.04e-07	-0.349000	6.94e-06
Cell-extracellular matrix interactions	15	1.93e-02	-0.349000	5.04e-02
RHO GTPases Activate NADPH Oxidases	22	4.61e-03	-0.349000	1.58e-02
Branched-chain ketoacid dehydrogenase kinase deficiency	5	1.78e-01	-0.348000	2.93e-01
Aflatoxin activation and detoxification	14	2.43e-02	-0.348000	6.04e-02
APC truncation mutants have impaired AXIN binding	14	2.44e-02	-0.347000	6.04e-02
AXIN missense mutants destabilize the destruction complex	14	2.44e-02	-0.347000	6.04e-02
Signaling by AMER1 mutants	14	2.44e-02	-0.347000	6.04e-02
Signaling by APC mutants	14	2.44e-02	-0.347000	6.04e-02
Signaling by AXIN mutants	14	2.44e-02	-0.347000	6.04e-02
Truncations of AMER1 destabilize the destruction complex	14	2.44e-02	-0.347000	6.04e-02
Removal of the Flap Intermediate from the C-strand	17	1.32e-02	-0.347000	3.70e-02
NADE modulates death signalling	5	1.79e-01	-0.347000	2.95e-01
Cellular responses to stress	697	4.82e-55	-0.346000	1.16e-52
Reactions specific to the complex N-glycan synthesis pathway	7	1.13e-01	-0.346000	2.08e-01
Nectin/Necl trans heterodimerization	5	1.81e-01	-0.346000	2.96e-01
Unfolded Protein Response (UPR)	85	3.64e-08	-0.345000	3.41e-07
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	3.83e-02	-0.345000	8.65e-02
alpha-linolenic acid (ALA) metabolism	12	3.83e-02	-0.345000	8.65e-02
TP53 Regulates Metabolic Genes	78	1.49e-07	-0.344000	1.24e-06
InlA-mediated entry of Listeria monocytogenes into host cells	9	7.46e-02	-0.343000	1.49e-01
Removal of the Flap Intermediate	14	2.62e-02	-0.343000	6.39e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	29	1.39e-03	-0.343000	5.82e-03
NFE2L2 regulates pentose phosphate pathway genes	8	9.34e-02	-0.343000	1.79e-01
Transcriptional regulation by RUNX2	89	2.42e-08	-0.342000	2.34e-07
Mitochondrial Fatty Acid Beta-Oxidation	36	3.84e-04	-0.342000	1.93e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	7.60e-02	-0.342000	1.51e-01
Eicosanoids	8	9.45e-02	0.341000	1.80e-01
ABC-family proteins mediated transport	81	1.08e-07	-0.341000	9.26e-07
Thyroxine biosynthesis	5	1.87e-01	0.341000	3.03e-01
Negative regulation of FGFR4 signaling	22	5.65e-03	-0.341000	1.87e-02
Downregulation of ERBB4 signaling	8	9.51e-02	-0.341000	1.81e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	3.55e-06	-0.340000	2.55e-05
Downstream TCR signaling	89	2.91e-08	-0.340000	2.78e-07
Regulation of BACH1 activity	11	5.09e-02	-0.340000	1.09e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	3.40e-02	-0.340000	7.91e-02
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	51	2.72e-05	-0.340000	1.69e-04
Glutathione synthesis and recycling	10	6.38e-02	-0.339000	1.32e-01
DNA Replication	128	3.93e-11	-0.338000	6.48e-10
Base Excision Repair	57	1.04e-05	-0.337000	6.87e-05
Translesion synthesis by REV1	16	1.95e-02	-0.337000	5.07e-02
Negative regulation of FGFR3 signaling	21	7.44e-03	-0.337000	2.37e-02
Mitochondrial iron-sulfur cluster biogenesis	13	3.54e-02	-0.337000	8.16e-02
ChREBP activates metabolic gene expression	7	1.23e-01	-0.337000	2.22e-01
Cellular responses to stimuli	778	1.51e-57	-0.336000	4.84e-55
Cleavage of the damaged pyrimidine	27	2.51e-03	-0.336000	9.68e-03
Depyrimidination	27	2.51e-03	-0.336000	9.68e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	2.51e-03	-0.336000	9.68e-03
Glycosaminoglycan metabolism	98	9.04e-09	-0.336000	9.36e-08
Glycine degradation	7	1.24e-01	-0.335000	2.23e-01
G1/S Transition	120	2.30e-10	-0.335000	3.36e-09
Telomere Extension By Telomerase	23	5.49e-03	-0.334000	1.82e-02
PECAM1 interactions	12	4.50e-02	-0.334000	9.92e-02
Digestion	5	1.96e-01	0.334000	3.14e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	4.62e-03	-0.334000	1.58e-02
CLEC7A (Dectin-1) signaling	86	8.70e-08	-0.334000	7.62e-07
Formation of tubulin folding intermediates by CCT/TriC	21	8.23e-03	-0.333000	2.57e-02
Integration of provirus	9	8.36e-02	-0.333000	1.64e-01
Telomere Maintenance	78	3.75e-07	-0.333000	3.00e-06
Erythropoietin activates RAS	13	3.78e-02	-0.333000	8.59e-02
Apoptotic factor-mediated response	19	1.21e-02	-0.333000	3.43e-02
Formation of apoptosome	11	5.62e-02	-0.332000	1.19e-01
Regulation of the apoptosome activity	11	5.62e-02	-0.332000	1.19e-01
Metabolism of carbohydrates	241	6.58e-19	-0.332000	2.23e-17
Protein folding	83	1.84e-07	-0.331000	1.52e-06
FGFR2 alternative splicing	25	4.24e-03	-0.330000	1.48e-02
Biosynthesis of E-series 18(S)-resolvins	5	2.01e-01	-0.330000	3.20e-01
Translesion synthesis by POLI	17	1.84e-02	-0.330000	4.85e-02
Association of TriC/CCT with target proteins during biosynthesis	35	7.25e-04	-0.330000	3.32e-03
Chaperone Mediated Autophagy	20	1.06e-02	-0.330000	3.13e-02
Germ layer formation at gastrulation	9	8.68e-02	0.330000	1.69e-01
SARS-CoV-1 Infection	137	2.86e-11	-0.329000	4.97e-10
Synthesis of DNA	108	3.41e-09	-0.329000	3.77e-08
Activation of PUMA and translocation to mitochondria	9	8.76e-02	-0.329000	1.69e-01
TNFR2 non-canonical NF-kB pathway	84	1.94e-07	-0.328000	1.60e-06
Glutathione conjugation	27	3.16e-03	-0.328000	1.17e-02
Metabolism of cofactors	25	4.52e-03	-0.328000	1.56e-02
Inflammasomes	21	9.28e-03	-0.328000	2.79e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	3.37e-02	-0.328000	7.87e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	3.37e-02	-0.328000	7.87e-02
Ketone body metabolism	8	1.09e-01	-0.328000	2.02e-01
MyD88 deficiency (TLR2/4)	14	3.39e-02	-0.327000	7.89e-02
Viral Infection Pathways	775	1.74e-54	-0.327000	3.73e-52
RHO GTPases Activate WASPs and WAVEs	35	8.27e-04	-0.327000	3.72e-03
RSK activation	7	1.35e-01	-0.326000	2.38e-01
Incretin synthesis, secretion, and inactivation	14	3.47e-02	-0.326000	8.02e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	3.47e-02	-0.326000	8.02e-02
APOBEC3G mediated resistance to HIV-1 infection	5	2.07e-01	-0.326000	3.27e-01
TBC/RABGAPs	45	1.55e-04	-0.326000	8.49e-04
Formation of axial mesoderm	6	1.67e-01	0.326000	2.80e-01
Regulation of signaling by CBL	22	8.17e-03	-0.326000	2.56e-02
Attachment and Entry 9694614	15	2.90e-02	-0.326000	6.97e-02
Nucleotide catabolism	28	2.87e-03	-0.325000	1.09e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	1.36e-01	0.325000	2.39e-01
Maturation of hRSV A proteins	13	4.24e-02	-0.325000	9.45e-02
Regulation of TP53 Activity through Association with Co-factors	13	4.27e-02	-0.325000	9.49e-02
Linoleic acid (LA) metabolism	7	1.37e-01	-0.325000	2.41e-01
Metabolic disorders of biological oxidation enzymes	23	7.13e-03	-0.324000	2.29e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	24	5.99e-03	-0.324000	1.97e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	4.32e-02	-0.324000	9.56e-02
InlB-mediated entry of Listeria monocytogenes into host cell	12	5.26e-02	-0.323000	1.13e-01
CRMPs in Sema3A signaling	14	3.63e-02	-0.323000	8.32e-02
MAPK6/MAPK4 signaling	69	3.80e-06	-0.322000	2.71e-05
DNA Damage Reversal	8	1.15e-01	-0.322000	2.11e-01
Apoptosis induced DNA fragmentation	10	7.83e-02	-0.322000	1.55e-01
Transport and synthesis of PAPS	6	1.73e-01	-0.321000	2.86e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	2.18e-02	-0.321000	5.57e-02
Interleukin-1 signaling	99	3.36e-08	-0.321000	3.16e-07
RAS processing	23	7.72e-03	-0.321000	2.44e-02
Chaperonin-mediated protein folding	77	1.14e-06	-0.321000	8.64e-06
Keratan sulfate degradation	9	9.59e-02	-0.320000	1.82e-01
Cellular response to mitochondrial stress	9	9.69e-02	-0.320000	1.84e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.46e-06	-0.319000	1.08e-05
Activation of BH3-only proteins	30	2.49e-03	-0.319000	9.67e-03
Nef and signal transduction	8	1.19e-01	-0.318000	2.17e-01
ROS and RNS production in phagocytes	30	2.59e-03	-0.318000	9.93e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	3.65e-03	-0.317000	1.32e-02
MAP2K and MAPK activation	36	1.02e-03	-0.316000	4.41e-03
Gap junction trafficking and regulation	30	2.71e-03	-0.316000	1.03e-02
Cytochrome c-mediated apoptotic response	13	4.85e-02	-0.316000	1.05e-01
Phospholipase C-mediated cascade; FGFR2	8	1.23e-01	0.315000	2.22e-01
Glycosphingolipid metabolism	46	2.18e-04	-0.315000	1.14e-03
Regulation of PTEN localization	9	1.02e-01	-0.315000	1.92e-01
Role of ABL in ROBO-SLIT signaling	6	1.83e-01	-0.314000	2.98e-01
Vitamin B1 (thiamin) metabolism	5	2.25e-01	-0.313000	3.49e-01
G beta:gamma signalling through PLC beta	17	2.53e-02	-0.313000	6.22e-02
Presynaptic function of Kainate receptors	17	2.53e-02	-0.313000	6.22e-02
Regulation of PTEN gene transcription	59	3.16e-05	-0.313000	1.92e-04
TYSND1 cleaves peroxisomal proteins	7	1.52e-01	-0.313000	2.58e-01
Plasma lipoprotein assembly, remodeling, and clearance	55	6.03e-05	-0.313000	3.51e-04
E3 ubiquitin ligases ubiquitinate target proteins	51	1.14e-04	-0.312000	6.38e-04
Processive synthesis on the lagging strand	15	3.63e-02	-0.312000	8.32e-02
Infectious disease	958	2.34e-60	-0.312000	9.03e-58
rRNA processing in the mitochondrion	24	8.35e-03	-0.311000	2.58e-02
Intrinsic Pathway for Apoptosis	54	7.97e-05	-0.310000	4.57e-04
Negative regulation of FGFR1 signaling	25	7.28e-03	-0.310000	2.33e-02
Transport of vitamins, nucleosides, and related molecules	31	2.81e-03	-0.310000	1.06e-02
HIV Infection	213	6.01e-15	-0.310000	1.43e-13
MicroRNA (miRNA) biogenesis	24	8.65e-03	-0.310000	2.63e-02
Dual incision in TC-NER	63	2.14e-05	-0.309000	1.35e-04
PTEN Regulation	127	1.75e-09	-0.309000	2.05e-08
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	2.49e-03	-0.309000	9.67e-03
RHO GTPases activate IQGAPs	25	7.56e-03	-0.309000	2.40e-02
Respiratory syncytial virus (RSV) attachment and entry	19	1.99e-02	-0.309000	5.16e-02
Scavenging by Class F Receptors	5	2.33e-01	-0.308000	3.58e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	5.47e-02	-0.308000	1.17e-01
MAPK1 (ERK2) activation	9	1.11e-01	-0.307000	2.04e-01
Mitotic G1 phase and G1/S transition	138	4.76e-10	-0.307000	6.37e-09
Basigin interactions	21	1.50e-02	-0.307000	4.04e-02
Post-chaperonin tubulin folding pathway	18	2.43e-02	-0.307000	6.04e-02
Interaction between L1 and Ankyrins	27	6.02e-03	0.305000	1.98e-02
Recognition of DNA damage by PCNA-containing replication complex	30	3.79e-03	-0.305000	1.36e-02
Peroxisomal protein import	58	5.94e-05	-0.305000	3.47e-04
MTOR signalling	39	9.91e-04	-0.305000	4.34e-03
Transport of nucleotide sugars	9	1.14e-01	-0.305000	2.09e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	1.97e-01	0.304000	3.16e-01
Potential therapeutics for SARS	150	1.32e-10	-0.304000	2.07e-09
Cytosolic tRNA aminoacylation	24	1.01e-02	-0.303000	3.00e-02
Downregulation of ERBB2:ERBB3 signaling	12	6.89e-02	-0.303000	1.41e-01
Prolonged ERK activation events	13	5.91e-02	-0.302000	1.24e-01
Macroautophagy	128	3.65e-09	-0.302000	3.99e-08
Aggrephagy	34	2.32e-03	-0.302000	9.13e-03
Selective autophagy	77	4.69e-06	-0.302000	3.30e-05
FGFR3 ligand binding and activation	5	2.43e-01	0.301000	3.72e-01
FGFR3c ligand binding and activation	5	2.43e-01	0.301000	3.72e-01
SARS-CoV-2 Infection	267	2.41e-17	-0.301000	7.49e-16
Autophagy	142	6.31e-10	-0.300000	8.10e-09
Synthesis of glycosylphosphatidylinositol (GPI)	18	2.74e-02	-0.300000	6.62e-02
Reversible hydration of carbon dioxide	8	1.43e-01	0.299000	2.46e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	7.10e-03	-0.299000	2.29e-02
FGFR2c ligand binding and activation	5	2.47e-01	0.299000	3.77e-01
Signaling by high-kinase activity BRAF mutants	33	2.93e-03	-0.299000	1.10e-02
Senescence-Associated Secretory Phenotype (SASP)	65	3.02e-05	-0.299000	1.86e-04
Nucleotide Excision Repair	108	8.07e-08	-0.299000	7.10e-07
Resolution of Abasic Sites (AP sites)	38	1.44e-03	-0.299000	6.03e-03
Glycogen breakdown (glycogenolysis)	13	6.23e-02	-0.299000	1.30e-01
Calcitonin-like ligand receptors	5	2.48e-01	0.298000	3.78e-01
Innate Immune System	970	8.81e-56	-0.298000	2.42e-53
Activated NOTCH1 Transmits Signal to the Nucleus	27	7.48e-03	-0.297000	2.37e-02
Metabolism	1827	1.80e-99	-0.297000	3.53e-96
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	4.94e-03	-0.296000	1.67e-02
Acetylcholine binding and downstream events	5	2.51e-01	0.296000	3.80e-01
Postsynaptic nicotinic acetylcholine receptors	5	2.51e-01	0.296000	3.80e-01
Trafficking and processing of endosomal TLR	13	6.44e-02	-0.296000	1.33e-01
G2 Phase	5	2.52e-01	-0.296000	3.81e-01
RNA Polymerase I Promoter Escape	45	5.92e-04	-0.296000	2.79e-03
Diseases of programmed cell death	58	9.69e-05	-0.296000	5.50e-04
PIWI-interacting RNA (piRNA) biogenesis	23	1.41e-02	-0.296000	3.90e-02
Defensins	8	1.48e-01	-0.296000	2.52e-01
Metal ion SLC transporters	19	2.62e-02	-0.295000	6.39e-02
PCNA-Dependent Long Patch Base Excision Repair	21	1.95e-02	-0.294000	5.07e-02
Axon guidance	459	3.21e-27	-0.294000	1.47e-25
Cation-coupled Chloride cotransporters	6	2.13e-01	0.294000	3.34e-01
Defective pyroptosis	27	8.30e-03	-0.293000	2.58e-02
Beta-catenin independent WNT signaling	126	1.34e-08	-0.293000	1.36e-07
Regulation of TP53 Activity through Methylation	19	2.74e-02	-0.292000	6.62e-02
SARS-CoV Infections	434	1.40e-25	-0.292000	5.98e-24
Calcineurin activates NFAT	9	1.29e-01	-0.292000	2.29e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	6.91e-02	-0.291000	1.41e-01
Alternative complement activation	5	2.60e-01	-0.291000	3.90e-01
Regulated proteolysis of p75NTR	11	9.47e-02	-0.291000	1.80e-01
rRNA modification in the nucleus and cytosol	60	9.71e-05	-0.291000	5.50e-04
Metabolism of proteins	1775	8.10e-93	-0.291000	7.80e-90
RNA Polymerase I Promoter Clearance	64	5.76e-05	-0.291000	3.38e-04
RNA Polymerase I Transcription	64	5.76e-05	-0.291000	3.38e-04
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.18e-01	-0.291000	3.41e-01
Suppression of apoptosis	7	1.84e-01	-0.290000	2.98e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	1.16e-04	-0.290000	6.51e-04
Nervous system development	478	1.56e-27	-0.290000	7.34e-26
activated TAK1 mediates p38 MAPK activation	23	1.62e-02	-0.290000	4.35e-02
TNFR1-mediated ceramide production	6	2.19e-01	-0.289000	3.43e-01
Recycling pathway of L1	40	1.57e-03	-0.289000	6.49e-03
Asparagine N-linked glycosylation	286	4.47e-17	-0.288000	1.35e-15
CD28 co-stimulation	33	4.21e-03	-0.288000	1.47e-02
Pre-NOTCH Processing in Golgi	18	3.47e-02	-0.287000	8.02e-02
Transcriptional regulation of brown and beige adipocyte differentiation	23	1.73e-02	-0.287000	4.59e-02
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	23	1.73e-02	-0.287000	4.59e-02
NoRC negatively regulates rRNA expression	60	1.23e-04	-0.287000	6.85e-04
ADP signalling through P2Y purinoceptor 1	21	2.31e-02	-0.286000	5.83e-02
Mitochondrial tRNA aminoacylation	21	2.31e-02	-0.286000	5.83e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	5.80e-06	-0.286000	4.00e-05
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	4.80e-02	-0.286000	1.04e-01
Synthesis of diphthamide-EEF2	8	1.63e-01	-0.285000	2.74e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.89e-02	-0.284000	1.06e-01
Platelet degranulation	105	4.77e-07	-0.284000	3.78e-06
CD28 dependent Vav1 pathway	12	8.85e-02	-0.284000	1.70e-01
Cargo recognition for clathrin-mediated endocytosis	87	4.83e-06	-0.284000	3.37e-05
Negative regulation of MAPK pathway	42	1.48e-03	-0.283000	6.16e-03
Voltage gated Potassium channels	27	1.09e-02	0.283000	3.19e-02
PRC2 methylates histones and DNA	27	1.11e-02	-0.282000	3.25e-02
CD163 mediating an anti-inflammatory response	9	1.43e-01	-0.282000	2.46e-01
Coenzyme A biosynthesis	7	1.96e-01	-0.282000	3.15e-01
tRNA Aminoacylation	42	1.60e-03	-0.281000	6.60e-03
Pyroptosis	25	1.49e-02	-0.281000	4.04e-02
Protein ubiquitination	71	4.22e-05	-0.281000	2.54e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	188	3.14e-11	-0.281000	5.38e-10
Thrombin signalling through proteinase activated receptors (PARs)	27	1.16e-02	-0.281000	3.34e-02
Metabolism of fat-soluble vitamins	28	1.02e-02	-0.280000	3.02e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.26e-01	-0.279000	2.25e-01
Transcriptional regulation of granulopoiesis	44	1.38e-03	-0.279000	5.80e-03
Triglyceride catabolism	15	6.22e-02	-0.278000	1.30e-01
Interleukin-1 family signaling	127	6.37e-08	-0.278000	5.71e-07
Translesion synthesis by POLK	17	4.74e-02	-0.278000	1.03e-01
Cholesterol biosynthesis	26	1.43e-02	-0.278000	3.94e-02
DNA replication initiation	8	1.75e-01	-0.277000	2.89e-01
Processing and activation of SUMO	10	1.29e-01	-0.277000	2.30e-01
Neddylation	216	2.44e-12	-0.276000	4.80e-11
TCR signaling	110	5.56e-07	-0.276000	4.39e-06
Zygotic genome activation (ZGA)	5	2.85e-01	0.276000	4.19e-01
Mitochondrial biogenesis	91	5.49e-06	-0.276000	3.81e-05
trans-Golgi Network Vesicle Budding	69	7.53e-05	-0.276000	4.36e-04
RUNX1 regulates expression of components of tight junctions	5	2.87e-01	0.275000	4.20e-01
Response to elevated platelet cytosolic Ca2+	109	7.25e-07	-0.275000	5.66e-06
Early Phase of HIV Life Cycle	14	7.53e-02	-0.275000	1.51e-01
COPI-independent Golgi-to-ER retrograde traffic	45	1.44e-03	-0.274000	6.04e-03
Processing of Capped Intronless Pre-mRNA	29	1.05e-02	-0.274000	3.11e-02
Synthesis, secretion, and deacylation of Ghrelin	11	1.15e-01	-0.274000	2.11e-01
VEGFR2 mediated vascular permeability	25	1.76e-02	-0.274000	4.66e-02
Uptake and function of anthrax toxins	11	1.16e-01	-0.273000	2.13e-01
Synthesis of 5-eicosatetraenoic acids	7	2.11e-01	-0.273000	3.32e-01
Prostacyclin signalling through prostacyclin receptor	16	5.88e-02	-0.273000	1.23e-01
tRNA modification in the mitochondrion	9	1.57e-01	-0.273000	2.65e-01
Cargo concentration in the ER	31	8.64e-03	-0.273000	2.63e-02
IRAK4 deficiency (TLR2/4)	15	6.80e-02	-0.272000	1.40e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	7.83e-02	-0.272000	1.55e-01
Negative epigenetic regulation of rRNA expression	63	1.94e-04	-0.271000	1.04e-03
VEGF binds to VEGFR leading to receptor dimerization	5	2.94e-01	-0.271000	4.26e-01
VEGF ligand-receptor interactions	5	2.94e-01	-0.271000	4.26e-01
RUNX2 regulates osteoblast differentiation	19	4.07e-02	-0.271000	9.11e-02
Activation of the pre-replicative complex	32	8.03e-03	-0.271000	2.52e-02
Metabolism of amine-derived hormones	10	1.39e-01	0.270000	2.42e-01
Oncogene Induced Senescence	33	7.25e-03	-0.270000	2.32e-02
Defective HLCS causes multiple carboxylase deficiency	7	2.16e-01	-0.270000	3.38e-01
FLT3 Signaling	38	4.03e-03	-0.270000	1.43e-02
Diseases associated with glycosylation precursor biosynthesis	15	7.08e-02	-0.269000	1.43e-01
SARS-CoV-2-host interactions	182	3.58e-10	-0.269000	5.07e-09
Signaling by NOTCH	173	1.04e-09	-0.269000	1.31e-08
Early SARS-CoV-2 Infection Events	32	8.52e-03	-0.269000	2.62e-02
Regulation of innate immune responses to cytosolic DNA	14	8.19e-02	-0.269000	1.61e-01
Butyrophilin (BTN) family interactions	10	1.42e-01	0.268000	2.45e-01
Chromatin modifications during the maternal to zygotic transition (MZT)	23	2.62e-02	-0.268000	6.39e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	4.31e-03	-0.268000	1.49e-02
Synthesis of 12-eicosatetraenoic acid derivatives	6	2.57e-01	-0.267000	3.87e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	2.07e-02	-0.267000	5.31e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.25e-01	-0.267000	2.23e-01
IRAK2 mediated activation of TAK1 complex	10	1.43e-01	-0.267000	2.47e-01
Positive epigenetic regulation of rRNA expression	60	3.44e-04	-0.267000	1.76e-03
G2/M Checkpoints	126	2.28e-07	-0.267000	1.84e-06
Sema3A PAK dependent Axon repulsion	16	6.46e-02	-0.267000	1.33e-01
ERK/MAPK targets	22	3.06e-02	-0.266000	7.27e-02
Pyruvate metabolism	44	2.28e-03	-0.266000	8.98e-03
Apoptosis	158	8.17e-09	-0.266000	8.56e-08
Trafficking of GluR2-containing AMPA receptors	11	1.27e-01	-0.266000	2.27e-01
TCF dependent signaling in response to WNT	152	1.64e-08	-0.265000	1.62e-07
GPER1 signaling	38	4.68e-03	-0.265000	1.59e-02
Processive synthesis on the C-strand of the telomere	19	4.61e-02	-0.264000	1.01e-01
Metabolism of RNA	717	1.82e-33	-0.264000	1.06e-31
PI-3K cascade:FGFR2	13	9.99e-02	0.264000	1.88e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	2.64e-01	-0.264000	3.95e-01
C-type lectin receptors (CLRs)	118	7.60e-07	-0.263000	5.91e-06
CD28 dependent PI3K/Akt signaling	22	3.25e-02	-0.263000	7.64e-02
Synthesis of PIPs at the early endosome membrane	16	6.83e-02	0.263000	1.40e-01
mRNA Editing	8	1.98e-01	0.263000	3.16e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	2.28e-01	-0.263000	3.54e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	6.88e-02	-0.263000	1.41e-01
Downregulation of ERBB2 signaling	24	2.59e-02	-0.263000	6.37e-02
Signaling by NTRK1 (TRKA)	102	4.63e-06	-0.262000	3.28e-05
Sphingolipid metabolism	92	1.36e-05	-0.262000	8.82e-05
MHC class II antigen presentation	113	1.47e-06	-0.262000	1.08e-05
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	4.79e-02	-0.262000	1.04e-01
Branched-chain amino acid catabolism	21	3.81e-02	-0.261000	8.64e-02
Na+/Cl- dependent neurotransmitter transporters	8	2.01e-01	0.261000	3.20e-01
Erythropoietin activates STAT5	6	2.68e-01	-0.261000	4.00e-01
Organic anion transporters	7	2.32e-01	-0.261000	3.58e-01
Transferrin endocytosis and recycling	26	2.13e-02	-0.261000	5.44e-02
Costimulation by the CD28 family	74	1.08e-04	-0.260000	6.10e-04
Cellular responses to mechanical stimuli	82	4.61e-05	-0.260000	2.75e-04
Response of endothelial cells to shear stress	82	4.61e-05	-0.260000	2.75e-04
Formation of RNA Pol II elongation complex	56	7.57e-04	-0.260000	3.44e-03
RNA Polymerase II Transcription Elongation	56	7.57e-04	-0.260000	3.44e-03
EPH-ephrin mediated repulsion of cells	43	3.17e-03	-0.260000	1.17e-02
DNA strand elongation	32	1.10e-02	-0.260000	3.21e-02
Activation of RAS in B cells	5	3.15e-01	0.260000	4.48e-01
APC-Cdc20 mediated degradation of Nek2A	26	2.21e-02	-0.259000	5.59e-02
Diseases of Mismatch Repair (MMR)	5	3.16e-01	0.259000	4.49e-01
Iron uptake and transport	52	1.24e-03	-0.259000	5.26e-03
Nuclear Events (kinase and transcription factor activation)	54	1.01e-03	-0.259000	4.39e-03
EPHB-mediated forward signaling	40	4.76e-03	-0.258000	1.61e-02
Protein methylation	15	8.40e-02	-0.258000	1.64e-01
SIRT1 negatively regulates rRNA expression	22	3.68e-02	-0.257000	8.40e-02
Digestion and absorption	7	2.39e-01	0.257000	3.67e-01
COPI-mediated anterograde transport	92	2.16e-05	-0.256000	1.36e-04
S Phase	150	6.28e-08	-0.256000	5.65e-07
HDACs deacetylate histones	45	3.00e-03	-0.256000	1.12e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	2.41e-02	-0.256000	6.02e-02
Hedgehog ‘off’ state	92	2.30e-05	-0.255000	1.44e-04
Diseases of Base Excision Repair	5	3.24e-01	-0.255000	4.58e-01
Assembly of active LPL and LIPC lipase complexes	10	1.64e-01	-0.254000	2.75e-01
Clathrin-mediated endocytosis	126	8.57e-07	-0.254000	6.61e-06
Signal amplification	28	2.02e-02	-0.254000	5.23e-02
Programmed Cell Death	187	2.26e-09	-0.253000	2.59e-08
G1/S-Specific Transcription	29	1.82e-02	-0.253000	4.80e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	7.96e-02	-0.253000	1.57e-01
DNA Damage/Telomere Stress Induced Senescence	42	4.56e-03	-0.253000	1.56e-02
RUNX2 regulates bone development	24	3.22e-02	-0.253000	7.62e-02
HIV Transcription Initiation	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II HIV Promoter Escape	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Promoter Escape	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Transcription Initiation	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	3.40e-03	-0.252000	1.23e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	3.40e-03	-0.252000	1.23e-02
Initiation of Nuclear Envelope (NE) Reformation	19	5.78e-02	-0.251000	1.22e-01
Transcription of the HIV genome	67	3.73e-04	-0.251000	1.88e-03
Inactivation of CDC42 and RAC1	7	2.51e-01	-0.251000	3.80e-01
Glucagon signaling in metabolic regulation	26	2.71e-02	-0.250000	6.58e-02
Depolymerization of the Nuclear Lamina	15	9.37e-02	-0.250000	1.79e-01
Collagen biosynthesis and modifying enzymes	46	3.36e-03	-0.250000	1.23e-02
G beta:gamma signalling through PI3Kgamma	22	4.25e-02	-0.250000	9.45e-02
Type I hemidesmosome assembly	8	2.21e-01	-0.250000	3.45e-01
Regulation of NF-kappa B signaling	18	6.67e-02	-0.250000	1.37e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	2.53e-01	-0.250000	3.82e-01
NGF-stimulated transcription	32	1.45e-02	-0.250000	3.96e-02
Smooth Muscle Contraction	34	1.20e-02	-0.249000	3.41e-02
PD-1 signaling	28	2.27e-02	-0.249000	5.75e-02
Activation of the phototransduction cascade	9	1.97e-01	0.248000	3.16e-01
HSF1 activation	26	2.84e-02	-0.248000	6.86e-02
EPH-Ephrin signaling	81	1.13e-04	-0.248000	6.35e-04
B-WICH complex positively regulates rRNA expression	45	4.07e-03	-0.247000	1.43e-02
Termination of translesion DNA synthesis	32	1.54e-02	-0.247000	4.16e-02
COPII-mediated vesicle transport	67	4.71e-04	-0.247000	2.27e-03
Disease	1623	6.22e-62	-0.247000	3.00e-59
Assembly of the ORC complex at the origin of replication	23	4.11e-02	-0.246000	9.18e-02
Sperm Motility And Taxes	6	2.97e-01	0.246000	4.29e-01
Synthesis of substrates in N-glycan biosythesis	59	1.09e-03	-0.246000	4.66e-03
RAF-independent MAPK1/3 activation	22	4.61e-02	-0.246000	1.01e-01
Reelin signalling pathway	5	3.42e-01	0.245000	4.78e-01
Signaling by NODAL	15	1.00e-01	-0.245000	1.89e-01
RHO GTPases activate PKNs	46	4.03e-03	-0.245000	1.43e-02
MET receptor recycling	9	2.03e-01	-0.245000	3.23e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	1.12e-02	-0.244000	3.25e-02
Post-translational protein phosphorylation	67	5.43e-04	-0.244000	2.58e-03
AMPK inhibits chREBP transcriptional activation activity	6	3.00e-01	-0.244000	4.33e-01
Reversal of alkylation damage by DNA dioxygenases	7	2.63e-01	-0.244000	3.94e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.14e-01	-0.244000	2.09e-01
Signaling by Hedgehog	121	3.56e-06	-0.244000	2.55e-05
Signaling by FLT3 fusion proteins	18	7.32e-02	0.244000	1.47e-01
Activation of HOX genes during differentiation	70	4.26e-04	-0.243000	2.10e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	4.26e-04	-0.243000	2.10e-03
Transport to the Golgi and subsequent modification	171	4.14e-08	-0.243000	3.81e-07
Phase 0 - rapid depolarisation	24	3.96e-02	0.243000	8.88e-02
Heme degradation	10	1.84e-01	-0.243000	2.99e-01
Metabolism of porphyrins	22	4.90e-02	-0.242000	1.06e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	3.48e-01	-0.242000	4.85e-01
Regulation of TP53 Expression and Degradation	36	1.19e-02	-0.242000	3.39e-02
Activation of gene expression by SREBF (SREBP)	42	6.58e-03	-0.242000	2.15e-02
Transcriptional regulation by RUNX3	80	1.91e-04	-0.241000	1.03e-03
Alpha-oxidation of phytanate	6	3.07e-01	-0.241000	4.40e-01
Sphingolipid de novo biosynthesis	35	1.37e-02	-0.241000	3.81e-02
N-glycan antennae elongation in the medial/trans-Golgi	21	5.63e-02	-0.241000	1.19e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	3.94e-03	-0.241000	1.40e-02
Signaling by NTRKs	116	7.99e-06	-0.240000	5.36e-05
FGFR2 mutant receptor activation	23	4.68e-02	-0.240000	1.02e-01
Ribavirin ADME	11	1.69e-01	-0.239000	2.82e-01
Translocation of ZAP-70 to Immunological synapse	24	4.24e-02	-0.239000	9.45e-02
Extension of Telomeres	51	3.15e-03	-0.239000	1.17e-02
Signaling by ERBB2	44	6.22e-03	-0.238000	2.04e-02
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	3.12e-01	-0.238000	4.46e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	3.12e-01	-0.238000	4.46e-01
EGFR downregulation	26	3.56e-02	-0.238000	8.19e-02
Dual Incision in GG-NER	41	8.36e-03	-0.238000	2.58e-02
ER to Golgi Anterograde Transport	145	7.72e-07	-0.238000	5.98e-06
IL-6-type cytokine receptor ligand interactions	13	1.38e-01	0.238000	2.42e-01
ADP signalling through P2Y purinoceptor 12	18	8.12e-02	-0.237000	1.60e-01
Chromosome Maintenance	103	3.13e-05	-0.237000	1.91e-04
Transcriptional regulation by small RNAs	61	1.34e-03	-0.237000	5.67e-03
Glucose metabolism	76	3.56e-04	-0.237000	1.82e-03
DARPP-32 events	22	5.50e-02	-0.236000	1.17e-01
Vesicle-mediated transport	665	2.61e-25	-0.236000	1.09e-23
Golgi Associated Vesicle Biogenesis	55	2.47e-03	-0.236000	9.63e-03
Signalling to ERKs	32	2.10e-02	-0.236000	5.38e-02
Phosphorylation of the APC/C	20	6.79e-02	-0.236000	1.40e-01
Pyrimidine catabolism	9	2.21e-01	-0.236000	3.45e-01
p38MAPK events	13	1.42e-01	-0.235000	2.45e-01
Oxidative Stress Induced Senescence	77	3.54e-04	-0.235000	1.81e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	1.42e-01	-0.235000	2.46e-01
Signaling by NOTCH3	42	8.41e-03	-0.235000	2.59e-02
Recycling of eIF2:GDP	8	2.50e-01	-0.235000	3.80e-01
Regulation of TP53 Degradation	35	1.63e-02	-0.235000	4.37e-02
Signaling by VEGF	99	5.51e-05	-0.235000	3.28e-04
Endogenous sterols	17	9.45e-02	-0.234000	1.80e-01
Signaling by WNT	240	4.36e-10	-0.234000	5.88e-09
Activation of RAC1	11	1.80e-01	-0.234000	2.95e-01
Integrin signaling	22	5.81e-02	-0.233000	1.22e-01
Signaling by Retinoic Acid	29	2.96e-02	-0.233000	7.08e-02
Class I peroxisomal membrane protein import	20	7.08e-02	-0.233000	1.43e-01
Semaphorin interactions	57	2.33e-03	-0.233000	9.16e-03
Regulation of KIT signaling	15	1.18e-01	-0.233000	2.16e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	8.73e-02	-0.233000	1.69e-01
Synthesis of PC	23	5.33e-02	-0.233000	1.14e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	3.24e-01	-0.233000	4.58e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	76	4.62e-04	-0.232000	2.25e-03
Diseases of metabolism	204	1.14e-08	-0.232000	1.17e-07
Formation of Incision Complex in GG-NER	43	8.56e-03	-0.232000	2.62e-02
Nuclear events stimulated by ALK signaling in cancer	33	2.14e-02	-0.231000	5.45e-02
Retinoid metabolism and transport	25	4.55e-02	-0.231000	9.99e-02
G-protein beta:gamma signalling	29	3.12e-02	-0.231000	7.42e-02
Synaptic adhesion-like molecules	17	9.90e-02	-0.231000	1.87e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.64e-02	-0.231000	4.38e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	6.09e-02	-0.231000	1.27e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	3.81e-02	-0.231000	8.64e-02
Signaling by Insulin receptor	63	1.55e-03	-0.231000	6.43e-03
Disorders of transmembrane transporters	136	3.56e-06	-0.230000	2.55e-05
PIP3 activates AKT signaling	234	1.34e-09	-0.230000	1.62e-08
Glycolysis	68	1.07e-03	-0.229000	4.59e-03
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	1.69e-01	-0.229000	2.82e-01
Transport of connexons to the plasma membrane	12	1.69e-01	-0.229000	2.82e-01
Sensing of DNA Double Strand Breaks	6	3.32e-01	0.229000	4.65e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.38e-01	-0.229000	2.42e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	3.32e-02	-0.228000	7.77e-02
Platelet activation, signaling and aggregation	221	4.80e-09	-0.228000	5.14e-08
Histidine catabolism	7	2.97e-01	-0.228000	4.29e-01
Hemostasis	558	3.89e-20	-0.227000	1.53e-18
Golgi-to-ER retrograde transport	123	1.33e-05	-0.227000	8.69e-05
Paracetamol ADME	19	8.63e-02	-0.227000	1.68e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	2.66e-01	-0.227000	3.98e-01
Chemokine receptors bind chemokines	41	1.18e-02	0.227000	3.39e-02
RHO GTPases Activate Rhotekin and Rhophilins	8	2.66e-01	-0.227000	3.98e-01
Proton-coupled monocarboxylate transport	6	3.36e-01	-0.227000	4.70e-01
Phosphate bond hydrolysis by NTPDase proteins	5	3.81e-01	-0.226000	5.16e-01
Signaling by WNT in cancer	30	3.23e-02	-0.226000	7.62e-02
Signalling to RAS	19	8.85e-02	-0.226000	1.70e-01
Formation of definitive endoderm	9	2.41e-01	0.226000	3.70e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	1.45e-01	-0.225000	2.49e-01
MET activates PI3K/AKT signaling	5	3.84e-01	0.225000	5.19e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.30e-02	-0.224000	3.65e-02
Signaling by RAS mutants	41	1.30e-02	-0.224000	3.65e-02
Signaling by moderate kinase activity BRAF mutants	41	1.30e-02	-0.224000	3.65e-02
Signaling downstream of RAS mutants	41	1.30e-02	-0.224000	3.65e-02
VEGFA-VEGFR2 Pathway	92	2.12e-04	-0.223000	1.12e-03
eNOS activation	11	2.00e-01	-0.223000	3.20e-01
Listeria monocytogenes entry into host cells	17	1.12e-01	-0.223000	2.05e-01
Bacterial Infection Pathways	65	1.90e-03	-0.223000	7.64e-03
Signaling by FGFR2	61	2.63e-03	-0.223000	1.01e-02
Thromboxane signalling through TP receptor	20	8.52e-02	-0.222000	1.66e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	5.20e-03	-0.222000	1.74e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	5.20e-03	-0.222000	1.74e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	5.20e-03	-0.222000	1.74e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	5.20e-03	-0.222000	1.74e-02
Signaling by NOTCH1 in Cancer	53	5.20e-03	-0.222000	1.74e-02
PKA activation in glucagon signalling	14	1.51e-01	-0.221000	2.58e-01
Recycling of bile acids and salts	10	2.25e-01	0.221000	3.49e-01
Synthesis of IP3 and IP4 in the cytosol	22	7.22e-02	-0.221000	1.46e-01
Regulation of TP53 Activity through Acetylation	29	3.90e-02	-0.221000	8.77e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	4.53e-03	-0.221000	1.56e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	9.99e-04	-0.221000	4.37e-03
Adaptive Immune System	771	1.35e-25	-0.221000	5.91e-24
HIV Life Cycle	144	4.66e-06	-0.221000	3.29e-05
Metabolism of nitric oxide: NOS3 activation and regulation	14	1.52e-01	-0.221000	2.59e-01
DNA Damage Bypass	47	8.80e-03	-0.221000	2.67e-02
Interleukin-12 signaling	44	1.13e-02	-0.221000	3.27e-02
Interleukin-17 signaling	68	1.65e-03	-0.221000	6.77e-03
RNA Polymerase III Transcription Initiation	36	2.20e-02	-0.221000	5.58e-02
DNA Double Strand Break Response	47	8.97e-03	-0.220000	2.71e-02
Biosynthesis of maresins	6	3.50e-01	0.220000	4.85e-01
Defects in biotin (Btn) metabolism	8	2.82e-01	-0.220000	4.17e-01
MAP kinase activation	63	2.59e-03	-0.219000	9.93e-03
Other semaphorin interactions	16	1.29e-01	-0.219000	2.30e-01
Late Phase of HIV Life Cycle	131	1.50e-05	-0.219000	9.71e-05
Mitotic Prophase	96	2.12e-04	-0.219000	1.12e-03
Condensation of Prometaphase Chromosomes	11	2.10e-01	-0.218000	3.31e-01
Cellular Senescence	143	6.49e-06	-0.218000	4.46e-05
CDC6 association with the ORC:origin complex	8	2.85e-01	0.218000	4.19e-01
Regulation of pyruvate metabolism	32	3.28e-02	-0.218000	7.68e-02
Glucagon-type ligand receptors	20	9.17e-02	-0.218000	1.75e-01
Vitamin D (calciferol) metabolism	11	2.12e-01	-0.217000	3.34e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	2.14e-01	-0.217000	3.35e-01
RNA Polymerase III Abortive And Retractive Initiation	40	1.78e-02	-0.216000	4.71e-02
RNA Polymerase III Transcription	40	1.78e-02	-0.216000	4.71e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	1.13e-02	-0.216000	3.27e-02
Syndecan interactions	25	6.16e-02	-0.216000	1.29e-01
Cross-presentation of particulate exogenous antigens (phagosomes)	8	2.91e-01	-0.216000	4.24e-01
Mitotic Anaphase	211	6.78e-08	-0.215000	6.05e-07
Intracellular signaling by second messengers	267	1.35e-09	-0.215000	1.63e-08
Regulation of FZD by ubiquitination	16	1.36e-01	-0.215000	2.39e-01
TNFs bind their physiological receptors	25	6.33e-02	-0.215000	1.31e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	1.52e-01	-0.214000	2.58e-01
Signaling by Activin	13	1.82e-01	-0.214000	2.97e-01
Sema4D in semaphorin signaling	22	8.26e-02	-0.214000	1.62e-01
Phase II - Conjugation of compounds	70	2.03e-03	-0.213000	8.08e-03
Mismatch Repair	15	1.53e-01	-0.213000	2.60e-01
Class I MHC mediated antigen processing & presentation	345	1.05e-11	-0.213000	1.95e-10
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.29e-01	-0.213000	2.29e-01
RNA Polymerase I Transcription Initiation	47	1.16e-02	-0.213000	3.34e-02
Impaired BRCA2 binding to PALB2	24	7.15e-02	0.213000	1.44e-01
Mitotic Metaphase and Anaphase	212	1.02e-07	-0.212000	8.73e-07
G beta:gamma signalling through CDC42	17	1.30e-01	-0.212000	2.31e-01
Regulation of signaling by NODAL	6	3.69e-01	-0.212000	5.05e-01
Separation of Sister Chromatids	168	2.16e-06	-0.212000	1.58e-05
Carboxyterminal post-translational modifications of tubulin	34	3.26e-02	-0.212000	7.65e-02
Interleukin-2 signaling	11	2.24e-01	-0.212000	3.48e-01
Negative regulation of FGFR2 signaling	24	7.30e-02	-0.211000	1.47e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	9	2.72e-01	-0.211000	4.04e-01
Pre-NOTCH Expression and Processing	63	3.71e-03	-0.211000	1.33e-02
Telomere C-strand synthesis initiation	13	1.87e-01	-0.211000	3.03e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	1.49e-04	-0.211000	8.18e-04
Toll Like Receptor TLR6:TLR2 Cascade	108	1.49e-04	-0.211000	8.18e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	1.88e-01	-0.211000	3.03e-01
ADORA2B mediated anti-inflammatory cytokines production	36	2.85e-02	-0.211000	6.86e-02
mRNA Splicing - Major Pathway	203	2.19e-07	-0.211000	1.78e-06
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	8.03e-02	-0.211000	1.58e-01
Signaling by FGFR	73	1.95e-03	-0.210000	7.82e-03
Post-translational protein modification	1245	1.21e-35	-0.210000	8.07e-34
Interleukin-1 processing	8	3.05e-01	-0.210000	4.38e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	6.23e-07	-0.209000	4.90e-06
HCMV Late Events	67	3.09e-03	-0.209000	1.15e-02
Transcriptional Regulation by TP53	346	2.35e-11	-0.209000	4.16e-10
Cardiogenesis	14	1.76e-01	-0.209000	2.91e-01
Metabolism of vitamins and cofactors	167	3.30e-06	-0.209000	2.39e-05
Molybdenum cofactor biosynthesis	6	3.77e-01	-0.208000	5.12e-01
Gastrulation	76	1.69e-03	-0.208000	6.86e-03
mRNA decay by 5’ to 3’ exoribonuclease	15	1.63e-01	-0.208000	2.74e-01
Platelet homeostasis	69	2.89e-03	-0.207000	1.09e-02
Bicarbonate transporters	9	2.83e-01	0.207000	4.17e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	8.69e-02	-0.206000	1.69e-01
Toll Like Receptor 2 (TLR2) Cascade	109	2.03e-04	-0.206000	1.08e-03
Toll Like Receptor TLR1:TLR2 Cascade	109	2.03e-04	-0.206000	1.08e-03
Defective GALNT3 causes HFTC	9	2.86e-01	0.205000	4.19e-01
Formation of the cornified envelope	37	3.13e-02	-0.205000	7.43e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	3.49e-01	-0.204000	4.85e-01
Regulation of CDH11 gene transcription	5	4.29e-01	-0.204000	5.64e-01
Lagging Strand Synthesis	20	1.14e-01	-0.204000	2.10e-01
RUNX1 regulates estrogen receptor mediated transcription	6	3.87e-01	0.204000	5.21e-01
TP53 Regulates Transcription of DNA Repair Genes	61	5.91e-03	-0.204000	1.95e-02
PI3K/AKT activation	8	3.18e-01	-0.204000	4.52e-01
Diseases of branched-chain amino acid catabolism	13	2.03e-01	-0.204000	3.23e-01
Signaling by Receptor Tyrosine Kinases	443	1.98e-13	-0.204000	4.24e-12
COPI-dependent Golgi-to-ER retrograde traffic	90	8.56e-04	-0.203000	3.84e-03
Developmental Biology	924	1.11e-25	-0.203000	4.96e-24
Peroxisomal lipid metabolism	27	6.78e-02	-0.203000	1.40e-01
Interleukin-18 signaling	6	3.90e-01	-0.203000	5.23e-01
Miro GTPase Cycle	8	3.21e-01	-0.203000	4.55e-01
Immune System	1841	3.06e-47	-0.203000	5.89e-45
Interleukin-12 family signaling	53	1.08e-02	-0.202000	3.18e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	6.89e-02	-0.202000	1.41e-01
CREB3 factors activate genes	6	3.91e-01	-0.202000	5.24e-01
mRNA Splicing	211	4.41e-07	-0.202000	3.51e-06
RND2 GTPase cycle	36	3.64e-02	-0.201000	8.33e-02
RA biosynthesis pathway	13	2.09e-01	-0.201000	3.29e-01
Acetylcholine regulates insulin secretion	9	2.96e-01	-0.201000	4.28e-01
Glycerophospholipid biosynthesis	105	3.67e-04	-0.201000	1.86e-03
Diseases of glycosylation	110	2.67e-04	-0.201000	1.39e-03
AKT phosphorylates targets in the cytosol	14	1.94e-01	-0.201000	3.11e-01
Polymerase switching on the C-strand of the telomere	26	7.67e-02	-0.201000	1.52e-01
Transcriptional regulation by RUNX1	170	6.73e-06	-0.200000	4.61e-05
RNA Polymerase II Pre-transcription Events	77	2.43e-03	-0.200000	9.51e-03
VEGFR2 mediated cell proliferation	18	1.43e-01	-0.199000	2.47e-01
Lipophagy	7	3.63e-01	-0.199000	5.00e-01
Membrane Trafficking	574	3.93e-16	-0.199000	1.02e-14
IRF3-mediated induction of type I IFN	12	2.34e-01	-0.199000	3.59e-01
Signaling by RAF1 mutants	37	3.66e-02	-0.199000	8.35e-02
GPVI-mediated activation cascade	32	5.22e-02	-0.198000	1.12e-01
HCMV Infection	106	4.27e-04	-0.198000	2.10e-03
Free fatty acids regulate insulin secretion	10	2.78e-01	-0.198000	4.12e-01
G beta:gamma signalling through BTK	15	1.85e-01	-0.198000	3.00e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	5.69e-02	-0.198000	1.20e-01
RNA Polymerase II Transcription Termination	66	5.51e-03	-0.198000	1.83e-02
Meiotic recombination	37	3.78e-02	-0.197000	8.59e-02
Keratan sulfate/keratin metabolism	28	7.08e-02	-0.197000	1.43e-01
Urea cycle	7	3.66e-01	-0.197000	5.04e-01
Interleukin-21 signaling	9	3.06e-01	0.197000	4.39e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	4.71e-02	-0.197000	1.03e-01
p75 NTR receptor-mediated signalling	89	1.34e-03	-0.197000	5.66e-03
RNA Polymerase I Transcription Termination	30	6.24e-02	-0.197000	1.30e-01
Gap junction assembly	17	1.61e-01	-0.196000	2.71e-01
AKT phosphorylates targets in the nucleus	10	2.83e-01	-0.196000	4.17e-01
RAB geranylgeranylation	63	7.29e-03	-0.195000	2.33e-02
Collagen formation	64	6.86e-03	-0.195000	2.23e-02
Signaling by NOTCH1	66	6.05e-03	-0.195000	1.99e-02
Nuclear Envelope (NE) Reassembly	68	5.41e-03	-0.195000	1.80e-02
Organic cation transport	8	3.42e-01	0.194000	4.77e-01
Organic cation/anion/zwitterion transport	8	3.42e-01	0.194000	4.77e-01
HATs acetylate histones	92	1.30e-03	-0.194000	5.53e-03
FOXO-mediated transcription of cell death genes	16	1.80e-01	-0.194000	2.95e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	3.15e-01	-0.193000	4.48e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	3.76e-01	-0.193000	5.12e-01
ERBB2 Regulates Cell Motility	10	2.91e-01	-0.193000	4.24e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.70e-01	-0.192000	2.83e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.70e-01	-0.192000	2.83e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.83e-01	-0.192000	2.98e-01
Constitutive Signaling by Overexpressed ERBB2	11	2.71e-01	-0.192000	4.02e-01
Meiotic synapsis	43	2.97e-02	-0.192000	7.08e-02
Evasion by RSV of host interferon responses	20	1.39e-01	-0.191000	2.42e-01
Fatty acid metabolism	157	3.55e-05	-0.191000	2.15e-04
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	1.34e-02	-0.191000	3.73e-02
Uptake of dietary cobalamins into enterocytes	6	4.18e-01	0.191000	5.53e-01
Rab regulation of trafficking	121	2.91e-04	-0.191000	1.51e-03
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	1.22e-01	-0.190000	2.21e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	3.83e-01	-0.190000	5.19e-01
Cyclin D associated events in G1	47	2.40e-02	-0.190000	6.02e-02
G1 Phase	47	2.40e-02	-0.190000	6.02e-02
NOTCH1 Intracellular Domain Regulates Transcription	44	2.91e-02	-0.190000	6.98e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	1.03e-03	-0.190000	4.47e-03
ALK mutants bind TKIs	11	2.76e-01	0.190000	4.10e-01
SMAC (DIABLO) binds to IAPs	7	3.86e-01	-0.189000	5.20e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	3.86e-01	-0.189000	5.20e-01
SMAC, XIAP-regulated apoptotic response	7	3.86e-01	-0.189000	5.20e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	8.23e-04	-0.189000	3.72e-03
Retrograde transport at the Trans-Golgi-Network	49	2.23e-02	-0.189000	5.65e-02
Signaling by Non-Receptor Tyrosine Kinases	47	2.54e-02	-0.188000	6.25e-02
Signaling by PTK6	47	2.54e-02	-0.188000	6.25e-02
Phase 4 - resting membrane potential	9	3.28e-01	-0.188000	4.63e-01
Purine salvage	12	2.59e-01	-0.188000	3.90e-01
Transcriptional regulation of testis differentiation	5	4.66e-01	0.188000	5.94e-01
Signaling by Nuclear Receptors	210	2.66e-06	-0.188000	1.94e-05
Antigen processing: Ubiquitination & Proteasome degradation	276	8.01e-08	-0.188000	7.08e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	1.09e-02	-0.187000	3.19e-02
MyD88 dependent cascade initiated on endosome	101	1.20e-03	-0.187000	5.10e-03
MyD88 cascade initiated on plasma membrane	95	1.68e-03	-0.186000	6.84e-03
Toll Like Receptor 10 (TLR10) Cascade	95	1.68e-03	-0.186000	6.84e-03
Toll Like Receptor 5 (TLR5) Cascade	95	1.68e-03	-0.186000	6.84e-03
MAPK1/MAPK3 signaling	231	1.16e-06	-0.186000	8.79e-06
Biological oxidations	143	1.29e-04	-0.185000	7.12e-04
PKA activation	15	2.14e-01	-0.185000	3.35e-01
RHO GTPase Effectors	259	2.82e-07	-0.185000	2.28e-06
Phosphorylation of CD3 and TCR zeta chains	27	9.58e-02	-0.185000	1.82e-01
Mitotic G2-G2/M phases	179	1.94e-05	-0.185000	1.24e-04
rRNA modification in the mitochondrion	8	3.65e-01	-0.185000	5.03e-01
Metabolism of steroid hormones	21	1.43e-01	-0.185000	2.47e-01
Signaling by FGFR4	32	7.09e-02	-0.184000	1.43e-01
Telomere C-strand (Lagging Strand) Synthesis	34	6.27e-02	-0.184000	1.30e-01
Regulation of HMOX1 expression and activity	5	4.76e-01	-0.184000	6.04e-01
Metabolism of Angiotensinogen to Angiotensins	12	2.71e-01	-0.184000	4.02e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	2.52e-01	-0.184000	3.81e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	1.78e-01	-0.184000	2.93e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	3.52e-02	-0.184000	8.11e-02
Diseases of signal transduction by growth factor receptors and second messengers	401	3.12e-10	-0.183000	4.45e-09
Activation of kainate receptors upon glutamate binding	26	1.07e-01	-0.183000	1.99e-01
Transcriptional regulation of pluripotent stem cells	19	1.69e-01	0.182000	2.82e-01
Post-translational modification: synthesis of GPI-anchored proteins	60	1.47e-02	-0.182000	4.00e-02
Defective LFNG causes SCDO3	5	4.81e-01	-0.182000	6.08e-01
Signaling by BRAF and RAF1 fusions	60	1.49e-02	-0.182000	4.04e-02
G2/M Transition	177	3.07e-05	-0.182000	1.88e-04
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	4.41e-01	-0.182000	5.74e-01
DNA Repair	289	1.09e-07	-0.182000	9.33e-07
FRS-mediated FGFR2 signaling	15	2.24e-01	0.181000	3.48e-01
Heme biosynthesis	13	2.58e-01	-0.181000	3.89e-01
Regulation of CDH11 mRNA translation by microRNAs	8	3.76e-01	0.181000	5.12e-01
Regulation of NPAS4 mRNA translation	8	3.76e-01	0.181000	5.12e-01
Pre-NOTCH Transcription and Translation	47	3.29e-02	-0.180000	7.71e-02
OAS antiviral response	8	3.79e-01	0.180000	5.15e-01
Generation of second messenger molecules	38	5.57e-02	-0.179000	1.18e-01
Cell Cycle Checkpoints	246	1.36e-06	-0.179000	1.01e-05
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	9	3.53e-01	-0.179000	4.88e-01
Signaling by FGFR3 in disease	14	2.47e-01	0.179000	3.78e-01
RAF/MAP kinase cascade	225	3.93e-06	-0.179000	2.80e-05
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	1.24e-01	0.178000	2.22e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	1.24e-01	0.178000	2.22e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	1.24e-01	0.178000	2.22e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	1.24e-01	0.178000	2.22e-01
IFNG signaling activates MAPKs	8	3.84e-01	-0.178000	5.19e-01
Notch-HLH transcription pathway	28	1.04e-01	-0.177000	1.95e-01
Keratinization	38	5.84e-02	-0.177000	1.23e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	1.81e-01	-0.177000	2.96e-01
Signal regulatory protein family interactions	13	2.69e-01	-0.177000	4.01e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.61e-01	-0.177000	2.71e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.61e-01	-0.177000	2.71e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	4.54e-01	0.177000	5.84e-01
SUMOylation of transcription factors	16	2.22e-01	-0.176000	3.45e-01
Negative regulators of DDX58/IFIH1 signaling	34	7.60e-02	-0.176000	1.51e-01
Disorders of Developmental Biology	12	2.92e-01	-0.176000	4.24e-01
Disorders of Nervous System Development	12	2.92e-01	-0.176000	4.24e-01
Loss of function of MECP2 in Rett syndrome	12	2.92e-01	-0.176000	4.24e-01
Pervasive developmental disorders	12	2.92e-01	-0.176000	4.24e-01
Ub-specific processing proteases	153	1.80e-04	-0.175000	9.77e-04
Cytosolic sensors of pathogen-associated DNA	63	1.62e-02	-0.175000	4.35e-02
RHOT2 GTPase cycle	7	4.23e-01	-0.175000	5.57e-01
M Phase	346	2.29e-08	-0.175000	2.23e-07
Signaling by FGFR1	42	5.02e-02	-0.175000	1.08e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	2.01e-01	-0.174000	3.20e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	2.01e-01	-0.174000	3.20e-01
Role of second messengers in netrin-1 signaling	6	4.61e-01	-0.174000	5.90e-01
G0 and Early G1	27	1.18e-01	-0.174000	2.16e-01
Carnitine shuttle	12	3.00e-01	-0.173000	4.32e-01
Uptake and function of diphtheria toxin	6	4.64e-01	-0.173000	5.94e-01
G alpha (z) signalling events	36	7.34e-02	-0.172000	1.47e-01
Other interleukin signaling	19	1.94e-01	-0.172000	3.12e-01
Viral Messenger RNA Synthesis	44	4.84e-02	-0.172000	1.05e-01
RAF activation	33	8.73e-02	-0.172000	1.69e-01
Regulated Necrosis	56	2.61e-02	-0.172000	6.39e-02
FGFR1b ligand binding and activation	5	5.06e-01	-0.172000	6.30e-01
Metabolism of steroids	123	1.01e-03	-0.172000	4.39e-03
Neurofascin interactions	5	5.07e-01	0.171000	6.30e-01
RHOH GTPase cycle	33	8.83e-02	-0.171000	1.70e-01
Ovarian tumor domain proteases	37	7.24e-02	-0.171000	1.46e-01
Common Pathway of Fibrin Clot Formation	13	2.87e-01	-0.171000	4.20e-01
Formation of the active cofactor, UDP-glucuronate	5	5.09e-01	-0.171000	6.32e-01
Mitochondrial RNA degradation	25	1.40e-01	-0.171000	2.43e-01
Fanconi Anemia Pathway	36	7.68e-02	-0.170000	1.52e-01
Erythrocytes take up carbon dioxide and release oxygen	11	3.29e-01	0.170000	4.64e-01
O2/CO2 exchange in erythrocytes	11	3.29e-01	0.170000	4.64e-01
Triglyceride metabolism	24	1.50e-01	-0.170000	2.55e-01
ESR-mediated signaling	157	2.39e-04	-0.170000	1.25e-03
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	3.31e-01	0.169000	4.65e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	1.09e-01	-0.169000	2.02e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	3.10e-01	-0.169000	4.44e-01
Signaling by EGFR in Cancer	22	1.70e-01	-0.169000	2.83e-01
Downstream signaling of activated FGFR2	20	1.91e-01	0.169000	3.08e-01
E2F mediated regulation of DNA replication	22	1.70e-01	-0.169000	2.83e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.20e-06	-0.169000	9.00e-06
Antimicrobial peptides	34	8.86e-02	-0.169000	1.70e-01
Transport of small molecules	556	1.01e-11	-0.169000	1.89e-10
Toll Like Receptor 4 (TLR4) Cascade	138	6.24e-04	-0.169000	2.93e-03
G-protein activation	19	2.04e-01	-0.168000	3.23e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	4.41e-01	-0.168000	5.74e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.24e-01	-0.168000	2.22e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	1.47e-01	-0.168000	2.51e-01
Toll-like Receptor Cascades	162	2.37e-04	-0.167000	1.24e-03
Reduction of cytosolic Ca++ levels	9	3.85e-01	-0.167000	5.20e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	3.16e-01	-0.167000	4.50e-01
Activated NTRK2 signals through RAS	6	4.78e-01	-0.167000	6.05e-01
Activated NTRK3 signals through RAS	6	4.78e-01	-0.167000	6.05e-01
Toll Like Receptor 9 (TLR9) Cascade	108	2.71e-03	-0.167000	1.03e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.34e-01	-0.167000	3.59e-01
RUNX3 regulates NOTCH signaling	14	2.82e-01	-0.166000	4.17e-01
SLC15A4:TASL-dependent IRF5 activation	6	4.82e-01	-0.166000	6.09e-01
Nucleotide-like (purinergic) receptors	14	2.83e-01	-0.166000	4.17e-01
Cell Cycle, Mitotic	488	4.12e-10	-0.165000	5.64e-09
Respiratory Syncytial Virus Infection Pathway	99	4.52e-03	-0.165000	1.56e-02
Response of EIF2AK1 (HRI) to heme deficiency	14	2.85e-01	-0.165000	4.19e-01
Deadenylation-dependent mRNA decay	50	4.36e-02	-0.165000	9.64e-02
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	8.57e-03	-0.165000	2.62e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	8.57e-03	-0.165000	2.62e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	8.57e-03	-0.165000	2.62e-02
RHOG GTPase cycle	70	1.71e-02	-0.165000	4.55e-02
Regulation of TP53 Activity	153	4.46e-04	-0.164000	2.19e-03
Metabolism of water-soluble vitamins and cofactors	116	2.22e-03	-0.164000	8.78e-03
Specification of primordial germ cells	6	4.86e-01	0.164000	6.13e-01
Post-transcriptional silencing by small RNAs	7	4.54e-01	0.163000	5.84e-01
CASP8 activity is inhibited	11	3.49e-01	0.163000	4.85e-01
Dimerization of procaspase-8	11	3.49e-01	0.163000	4.85e-01
Regulation by c-FLIP	11	3.49e-01	0.163000	4.85e-01
RHOQ GTPase cycle	54	3.88e-02	-0.163000	8.73e-02
Deubiquitination	225	2.67e-05	-0.162000	1.66e-04
Polo-like kinase mediated events	16	2.61e-01	-0.162000	3.92e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.99e-02	-0.162000	5.16e-02
PI3K events in ERBB4 signaling	6	4.93e-01	0.162000	6.20e-01
Sodium/Calcium exchangers	9	4.02e-01	-0.161000	5.35e-01
Maturation of protein 3a 9683673	9	4.02e-01	-0.161000	5.35e-01
Maturation of protein 3a 9694719	9	4.02e-01	-0.161000	5.35e-01
Creatine metabolism	6	4.94e-01	0.161000	6.21e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	3.55e-01	0.161000	4.91e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.48e-01	0.161000	2.53e-01
Platelet calcium homeostasis	22	1.92e-01	-0.161000	3.10e-01
Neurotoxicity of clostridium toxins	8	4.32e-01	0.160000	5.67e-01
RAB GEFs exchange GTP for GDP on RABs	88	9.33e-03	-0.160000	2.79e-02
SARS-CoV-1 activates/modulates innate immune responses	40	8.00e-02	-0.160000	1.58e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	3.01e-01	-0.160000	4.33e-01
MAPK family signaling cascades	263	8.46e-06	-0.159000	5.66e-05
TGF-beta receptor signaling activates SMADs	45	6.44e-02	-0.159000	1.33e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	9.81e-02	-0.159000	1.86e-01
Anchoring fibril formation	8	4.38e-01	-0.158000	5.73e-01
Gene Silencing by RNA	87	1.13e-02	-0.157000	3.27e-02
RUNX3 Regulates Immune Response and Cell Migration	5	5.44e-01	-0.157000	6.69e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	4.43e-01	-0.157000	5.74e-01
CDH11 homotypic and heterotypic interactions	5	5.44e-01	-0.157000	6.70e-01
Opioid Signalling	75	1.90e-02	-0.157000	4.98e-02
Intra-Golgi traffic	43	7.61e-02	-0.156000	1.51e-01
Synthesis of PE	12	3.49e-01	-0.156000	4.85e-01
G alpha (s) signalling events	96	8.24e-03	-0.156000	2.57e-02
Inositol phosphate metabolism	42	8.02e-02	-0.156000	1.58e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	3.50e-01	-0.156000	4.85e-01
Elevation of cytosolic Ca2+ levels	13	3.31e-01	-0.156000	4.65e-01
Erythropoietin activates Phospholipase C gamma (PLCG)	6	5.09e-01	-0.156000	6.32e-01
Methylation	13	3.32e-01	-0.155000	4.65e-01
Diseases associated with surfactant metabolism	5	5.48e-01	0.155000	6.72e-01
Cohesin Loading onto Chromatin	10	3.95e-01	0.155000	5.27e-01
Drug ADME	57	4.28e-02	-0.155000	9.49e-02
Maturation of nucleoprotein 9683610	11	3.73e-01	-0.155000	5.10e-01
Signaling by Interleukins	390	1.47e-07	-0.155000	1.23e-06
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	4.22e-01	-0.155000	5.56e-01
Receptor-type tyrosine-protein phosphatases	11	3.75e-01	0.155000	5.12e-01
PKA-mediated phosphorylation of CREB	17	2.70e-01	-0.154000	4.02e-01
Ras activation upon Ca2+ influx through NMDA receptor	18	2.57e-01	0.154000	3.87e-01
Estrogen-dependent gene expression	96	9.02e-03	-0.154000	2.73e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.33e-01	-0.154000	3.58e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	37	1.05e-01	-0.154000	1.97e-01
Downregulation of TGF-beta receptor signaling	26	1.75e-01	-0.154000	2.89e-01
Cell Cycle	611	9.59e-11	-0.153000	1.53e-09
Metabolism of lipids	641	3.50e-11	-0.153000	5.86e-10
NPAS4 regulates expression of target genes	16	2.89e-01	-0.153000	4.22e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	5	5.54e-01	0.153000	6.78e-01
Transcriptional Regulation by E2F6	34	1.23e-01	-0.153000	2.22e-01
Sema4D induced cell migration and growth-cone collapse	19	2.49e-01	-0.153000	3.79e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	3.06e-01	-0.153000	4.39e-01
Diseases associated with the TLR signaling cascade	29	1.56e-01	-0.152000	2.64e-01
Diseases of Immune System	29	1.56e-01	-0.152000	2.64e-01
tRNA processing	128	2.94e-03	-0.152000	1.10e-02
TAK1-dependent IKK and NF-kappa-B activation	43	8.43e-02	-0.152000	1.65e-01
Oncogenic MAPK signaling	76	2.20e-02	-0.152000	5.59e-02
DNA Double-Strand Break Repair	137	2.17e-03	-0.152000	8.59e-03
Signaling by MET	68	3.05e-02	-0.152000	7.26e-02
Interleukin-27 signaling	11	3.85e-01	-0.151000	5.20e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	1.81e-01	-0.151000	2.96e-01
RHOT1 GTPase cycle	5	5.58e-01	-0.151000	6.81e-01
PERK regulates gene expression	31	1.46e-01	-0.151000	2.50e-01
Signaling by PDGFR in disease	19	2.56e-01	0.151000	3.86e-01
SUMOylation of intracellular receptors	26	1.84e-01	-0.150000	2.99e-01
RHOF GTPase cycle	38	1.09e-01	-0.150000	2.03e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	1.11e-01	-0.149000	2.05e-01
Nucleosome assembly	38	1.11e-01	-0.149000	2.05e-01
RHO GTPases Activate Formins	128	3.70e-03	-0.149000	1.33e-02
Activation of caspases through apoptosome-mediated cleavage	6	5.29e-01	-0.148000	6.54e-01
IKK complex recruitment mediated by RIP1	23	2.19e-01	-0.148000	3.43e-01
Integration of energy metabolism	88	1.66e-02	-0.148000	4.41e-02
PI5P Regulates TP53 Acetylation	8	4.70e-01	-0.147000	5.99e-01
Mitochondrial unfolded protein response (UPRmt)	17	2.93e-01	-0.147000	4.25e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	5.00e-01	-0.147000	6.25e-01
TGFBR3 expression	20	2.56e-01	0.147000	3.86e-01
Signaling by LTK in cancer	7	5.02e-01	-0.147000	6.26e-01
Signaling by NOTCH2	33	1.45e-01	-0.146000	2.50e-01
Tie2 Signaling	16	3.11e-01	-0.146000	4.44e-01
MyD88-independent TLR4 cascade	108	8.67e-03	-0.146000	2.63e-02
TRIF (TICAM1)-mediated TLR4 signaling	108	8.67e-03	-0.146000	2.63e-02
Insulin receptor signalling cascade	40	1.11e-01	-0.146000	2.04e-01
Biosynthesis of EPA-derived SPMs	6	5.36e-01	-0.146000	6.62e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	3.46e-01	-0.146000	4.82e-01
Relaxin receptors	5	5.73e-01	-0.145000	6.93e-01
Loss of Function of TGFBR1 in Cancer	7	5.06e-01	-0.145000	6.30e-01
Response to metal ions	6	5.40e-01	-0.144000	6.66e-01
Activation of ATR in response to replication stress	37	1.30e-01	-0.144000	2.31e-01
Signaling by FGFR3	32	1.61e-01	-0.143000	2.71e-01
Homology Directed Repair	110	9.63e-03	-0.143000	2.87e-02
Effects of PIP2 hydrolysis	24	2.26e-01	-0.143000	3.51e-01
Extra-nuclear estrogen signaling	65	4.70e-02	-0.142000	1.03e-01
RHOA GTPase cycle	138	3.92e-03	-0.142000	1.40e-02
N-Glycan antennae elongation	13	3.75e-01	-0.142000	5.12e-01
RHOC GTPase cycle	71	3.84e-02	-0.142000	8.66e-02
Signaling by SCF-KIT	40	1.20e-01	-0.142000	2.18e-01
Maternal to zygotic transition (MZT)	72	3.73e-02	-0.142000	8.51e-02
Physiological factors	9	4.61e-01	0.142000	5.90e-01
Transcription of E2F targets under negative control by DREAM complex	19	2.85e-01	-0.142000	4.19e-01
PI-3K cascade:FGFR3	10	4.38e-01	0.142000	5.73e-01
VxPx cargo-targeting to cilium	19	2.86e-01	-0.142000	4.19e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	4.89e-01	-0.141000	6.16e-01
NR1H2 and NR1H3-mediated signaling	38	1.32e-01	-0.141000	2.33e-01
SUMOylation of transcription cofactors	44	1.06e-01	-0.141000	1.98e-01
tRNA processing in the nucleus	59	6.13e-02	-0.141000	1.28e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	3.80e-01	0.141000	5.15e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	18	3.02e-01	-0.141000	4.34e-01
The canonical retinoid cycle in rods (twilight vision)	9	4.65e-01	-0.141000	5.94e-01
Plasma lipoprotein remodeling	18	3.02e-01	-0.141000	4.34e-01
Negative regulation of the PI3K/AKT network	91	2.05e-02	-0.141000	5.28e-02
RHOU GTPase cycle	40	1.24e-01	-0.140000	2.23e-01
Extracellular matrix organization	219	3.41e-04	-0.140000	1.75e-03
Toll Like Receptor 3 (TLR3) Cascade	104	1.34e-02	-0.140000	3.74e-02
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	4.22e-01	-0.140000	5.56e-01
ECM proteoglycans	47	9.70e-02	-0.140000	1.84e-01
Amine ligand-binding receptors	10	4.47e-01	0.139000	5.79e-01
STAT5 activation downstream of FLT3 ITD mutants	9	4.71e-01	-0.139000	5.99e-01
STING mediated induction of host immune responses	15	3.53e-01	-0.139000	4.88e-01
Aquaporin-mediated transport	38	1.39e-01	-0.139000	2.43e-01
RSV-host interactions	78	3.46e-02	-0.138000	8.02e-02
NFE2L2 regulating ER-stress associated genes	5	5.94e-01	0.138000	7.11e-01
RUNX3 regulates p14-ARF	10	4.53e-01	0.137000	5.84e-01
RAC2 GTPase cycle	85	2.94e-02	-0.137000	7.04e-02
TP53 Regulates Transcription of Cell Death Genes	43	1.22e-01	-0.136000	2.22e-01
Interleukin-10 signaling	39	1.41e-01	0.136000	2.45e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	5.98e-01	-0.136000	7.11e-01
Activation of SMO	14	3.79e-01	-0.136000	5.15e-01
PLC beta mediated events	40	1.38e-01	-0.136000	2.42e-01
RHOJ GTPase cycle	49	1.01e-01	-0.135000	1.90e-01
Metalloprotease DUBs	20	2.96e-01	-0.135000	4.28e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	4.83e-01	0.135000	6.10e-01
Signaling by FGFR4 in disease	11	4.39e-01	0.135000	5.73e-01
Meiosis	67	5.66e-02	-0.135000	1.20e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	2.86e-01	-0.134000	4.20e-01
Passive transport by Aquaporins	6	5.69e-01	0.134000	6.90e-01
Establishment of Sister Chromatid Cohesion	11	4.41e-01	0.134000	5.74e-01
Chromatin modifying enzymes	214	7.21e-04	-0.134000	3.32e-03
Chromatin organization	214	7.21e-04	-0.134000	3.32e-03
SHC1 events in EGFR signaling	11	4.41e-01	-0.134000	5.74e-01
Transport of RCbl within the body	8	5.12e-01	-0.134000	6.34e-01
RHOV GTPase cycle	36	1.65e-01	-0.134000	2.76e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	623	1.53e-08	-0.133000	1.52e-07
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	3.90e-01	-0.133000	5.23e-01
Regulation of PTEN mRNA translation	13	4.08e-01	0.133000	5.41e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	1.35e-02	-0.132000	3.75e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	3.06e-01	-0.132000	4.39e-01
Signaling by EGFR	47	1.17e-01	-0.132000	2.15e-01
Defective binding of VWF variant to GPIb:IX:V	6	5.76e-01	0.132000	6.95e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	6	5.76e-01	0.132000	6.95e-01
Formation of the beta-catenin:TCF transactivating complex	44	1.31e-01	-0.132000	2.31e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	2.06e-02	-0.131000	5.31e-02
Signaling by ALK fusions and activated point mutants	89	3.24e-02	-0.131000	7.62e-02
Signaling by ALK in cancer	89	3.24e-02	-0.131000	7.62e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	35	1.80e-01	-0.131000	2.95e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	5.79e-01	-0.131000	6.97e-01
MITF-M-regulated melanocyte development	113	1.64e-02	-0.131000	4.38e-02
mRNA 3’-end processing	57	8.85e-02	-0.130000	1.70e-01
Formation of the ureteric bud	5	6.14e-01	0.130000	7.24e-01
RAC3 GTPase cycle	87	3.62e-02	-0.130000	8.29e-02
ABC transporters in lipid homeostasis	14	4.00e-01	0.130000	5.33e-01
Adipogenesis	95	2.88e-02	-0.130000	6.92e-02
PI3K events in ERBB2 signaling	11	4.58e-01	0.129000	5.88e-01
FOXO-mediated transcription	58	9.03e-02	-0.129000	1.73e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	6.19e-01	-0.129000	7.27e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	6.19e-01	-0.129000	7.27e-01
Cargo trafficking to the periciliary membrane	48	1.24e-01	-0.128000	2.22e-01
Signaling by TGF-beta Receptor Complex	90	3.57e-02	-0.128000	8.19e-02
Activation of the AP-1 family of transcription factors	10	4.84e-01	-0.128000	6.11e-01
Diseases of mitotic cell cycle	38	1.73e-01	-0.128000	2.87e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	6.22e-01	0.127000	7.29e-01
Signaling by KIT in disease	20	3.28e-01	-0.126000	4.63e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	3.28e-01	-0.126000	4.63e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	6.25e-01	-0.126000	7.30e-01
Acyl chain remodelling of PE	20	3.29e-01	-0.126000	4.64e-01
Apoptotic execution phase	46	1.41e-01	-0.125000	2.45e-01
Fibronectin matrix formation	6	5.96e-01	-0.125000	7.11e-01
Signal Transduction	2051	9.41e-21	-0.125000	3.78e-19
Signaling by Rho GTPases	607	1.45e-07	-0.125000	1.23e-06
Formation of the Editosome	6	5.97e-01	0.125000	7.11e-01
mRNA Editing: C to U Conversion	6	5.97e-01	0.125000	7.11e-01
Transcriptional activation of mitochondrial biogenesis	52	1.21e-01	-0.124000	2.20e-01
NFE2L2 regulating tumorigenic genes	11	4.76e-01	0.124000	6.04e-01
MET promotes cell motility	34	2.11e-01	-0.124000	3.32e-01
Organelle biogenesis and maintenance	278	3.74e-04	-0.124000	1.88e-03
SHC-mediated cascade:FGFR2	13	4.39e-01	0.124000	5.73e-01
SOS-mediated signalling	7	5.70e-01	-0.124000	6.91e-01
RAS signaling downstream of NF1 loss-of-function variants	7	5.71e-01	-0.124000	6.91e-01
p130Cas linkage to MAPK signaling for integrins	11	4.78e-01	-0.123000	6.05e-01
HCMV Early Events	84	5.07e-02	-0.123000	1.09e-01
Downstream signal transduction	27	2.68e-01	-0.123000	4.00e-01
Integrin cell surface interactions	65	8.61e-02	-0.123000	1.68e-01
PKR-mediated signaling	67	8.19e-02	-0.123000	1.61e-01
NOD1/2 Signaling Pathway	36	2.04e-01	-0.122000	3.23e-01
G-protein mediated events	44	1.60e-01	-0.122000	2.71e-01
Rap1 signalling	14	4.29e-01	-0.122000	5.64e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	5.36e-02	-0.122000	1.15e-01
Signaling by RNF43 mutants	7	5.78e-01	-0.121000	6.96e-01
Death Receptor Signaling	145	1.17e-02	-0.121000	3.35e-02
Signaling by TGFB family members	137	1.42e-02	-0.121000	3.94e-02
SHC1 events in ERBB2 signaling	17	3.89e-01	-0.121000	5.23e-01
Non-integrin membrane-ECM interactions	49	1.46e-01	-0.120000	2.50e-01
RHOD GTPase cycle	49	1.46e-01	-0.120000	2.50e-01
Protein lipoylation	10	5.11e-01	-0.120000	6.34e-01
RHOB GTPase cycle	64	9.86e-02	-0.119000	1.87e-01
Cytokine Signaling in Immune system	668	1.49e-07	-0.119000	1.24e-06
Processing of Intronless Pre-mRNAs	20	3.59e-01	-0.118000	4.96e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	4.97e-01	0.118000	6.23e-01
Negative regulation of MET activity	18	3.86e-01	-0.118000	5.20e-01
Interleukin-6 family signaling	20	3.62e-01	0.118000	5.00e-01
SHC-mediated cascade:FGFR1	13	4.63e-01	-0.118000	5.92e-01
HDL assembly	6	6.18e-01	-0.117000	7.27e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	5.95e-01	0.116000	7.11e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	3.76e-02	-0.116000	8.54e-02
Nonhomologous End-Joining (NHEJ)	40	2.05e-01	-0.116000	3.25e-01
Activation of AMPK downstream of NMDARs	20	3.71e-01	-0.116000	5.08e-01
SLC-mediated transmembrane transport	174	8.52e-03	-0.116000	2.62e-02
Leading Strand Synthesis	14	4.54e-01	-0.116000	5.84e-01
Polymerase switching	14	4.54e-01	-0.116000	5.84e-01
Phospholipid metabolism	183	7.10e-03	-0.115000	2.29e-02
Signaling by MAPK mutants	6	6.25e-01	-0.115000	7.30e-01
Regulation of TNFR1 signaling	47	1.72e-01	-0.115000	2.86e-01
Regulation of MITF-M-dependent genes involved in pigmentation	38	2.20e-01	-0.115000	3.43e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	1.68e-01	-0.115000	2.81e-01
SUMO is proteolytically processed	6	6.27e-01	-0.115000	7.32e-01
POLB-Dependent Long Patch Base Excision Repair	8	5.76e-01	-0.114000	6.95e-01
Maturation of nucleoprotein 9694631	15	4.45e-01	-0.114000	5.77e-01
Signaling by PDGF	48	1.73e-01	-0.114000	2.86e-01
DCC mediated attractive signaling	13	4.78e-01	-0.114000	6.05e-01
Dectin-2 family	19	3.91e-01	-0.114000	5.24e-01
Vitamin B5 (pantothenate) metabolism	20	3.80e-01	-0.113000	5.15e-01
Ca-dependent events	30	2.83e-01	-0.113000	4.17e-01
SUMOylation of chromatin organization proteins	57	1.39e-01	-0.113000	2.42e-01
Synthesis of 15-eicosatetraenoic acid derivatives	6	6.31e-01	-0.113000	7.36e-01
CaMK IV-mediated phosphorylation of CREB	9	5.57e-01	0.113000	6.80e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	4.35e-01	0.113000	5.70e-01
Signaling by TGFBR3	39	2.23e-01	-0.113000	3.47e-01
MET activates PTK2 signaling	23	3.50e-01	-0.113000	4.85e-01
Diseases of hemostasis	14	4.66e-01	-0.113000	5.94e-01
Sensory processing of sound by outer hair cells of the cochlea	41	2.14e-01	-0.112000	3.36e-01
Cellular response to heat stress	94	6.10e-02	-0.112000	1.28e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	1.19e-01	-0.111000	2.17e-01
FGFR2b ligand binding and activation	6	6.39e-01	0.110000	7.41e-01
RET signaling	32	2.81e-01	-0.110000	4.16e-01
Degradation of the extracellular matrix	96	6.25e-02	-0.110000	1.30e-01
Impaired BRCA2 binding to RAD51	35	2.62e-01	0.110000	3.93e-01
Signaling by FGFR2 in disease	33	2.76e-01	-0.109000	4.10e-01
RND3 GTPase cycle	35	2.65e-01	-0.109000	3.96e-01
Interleukin-35 Signalling	12	5.14e-01	-0.109000	6.36e-01
MITF-M-dependent gene expression	84	8.46e-02	-0.109000	1.65e-01
MET activates RAP1 and RAC1	10	5.52e-01	-0.109000	6.76e-01
Amino acid transport across the plasma membrane	25	3.47e-01	-0.109000	4.84e-01
PI3K/AKT Signaling in Cancer	84	8.61e-02	-0.108000	1.68e-01
Propionyl-CoA catabolism	5	6.76e-01	-0.108000	7.70e-01
Defects in vitamin and cofactor metabolism	21	3.93e-01	-0.108000	5.26e-01
Phase I - Functionalization of compounds	68	1.25e-01	-0.108000	2.23e-01
MET activates RAS signaling	10	5.56e-01	-0.108000	6.80e-01
Collagen degradation	42	2.30e-01	-0.107000	3.55e-01
LTC4-CYSLTR mediated IL4 production	5	6.79e-01	-0.107000	7.72e-01
Sphingolipid catabolism	11	5.44e-01	-0.106000	6.69e-01
Toxicity of botulinum toxin type D (botD)	5	6.82e-01	0.106000	7.74e-01
Toxicity of botulinum toxin type F (botF)	5	6.82e-01	0.106000	7.74e-01
Synthesis of PIPs at the Golgi membrane	16	4.66e-01	-0.105000	5.94e-01
NFE2L2 regulating MDR associated enzymes	8	6.07e-01	0.105000	7.17e-01
PI3K Cascade	31	3.11e-01	-0.105000	4.44e-01
Receptor Mediated Mitophagy	11	5.47e-01	-0.105000	6.72e-01
Small interfering RNA (siRNA) biogenesis	9	5.90e-01	-0.104000	7.07e-01
TNF signaling	56	1.79e-01	-0.104000	2.94e-01
Platelet Aggregation (Plug Formation)	29	3.36e-01	-0.103000	4.70e-01
RUNX1 regulates transcription of genes involved in WNT signaling	5	6.90e-01	0.103000	7.80e-01
Sensory Perception	194	1.33e-02	0.103000	3.71e-02
Phospholipase C-mediated cascade; FGFR3	5	6.92e-01	0.102000	7.82e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	3.09e-01	-0.102000	4.42e-01
Signaling by Leptin	10	5.76e-01	-0.102000	6.95e-01
RHO GTPases activate PAKs	20	4.30e-01	-0.102000	5.64e-01
Post NMDA receptor activation events	64	1.60e-01	-0.102000	2.70e-01
SUMO E3 ligases SUMOylate target proteins	161	2.62e-02	-0.102000	6.39e-02
Transcriptional regulation of white adipocyte differentiation	77	1.24e-01	-0.102000	2.22e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	3.90e-01	-0.101000	5.23e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	6.43e-01	0.101000	7.44e-01
Hydrolysis of LPC	8	6.20e-01	-0.101000	7.28e-01
Peptide hormone metabolism	53	2.03e-01	-0.101000	3.23e-01
SUMOylation of RNA binding proteins	47	2.31e-01	-0.101000	3.56e-01
Adenylate cyclase inhibitory pathway	11	5.63e-01	-0.101000	6.85e-01
The phototransduction cascade	27	3.68e-01	0.100000	5.05e-01
HDMs demethylate histones	22	4.16e-01	0.100000	5.51e-01
TLR3-mediated TICAM1-dependent programmed cell death	6	6.72e-01	0.099900	7.67e-01
cGMP effects	12	5.49e-01	0.099800	6.74e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	5.85e-01	-0.099700	7.03e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	6.28e-01	-0.098900	7.33e-01
GP1b-IX-V activation signalling	11	5.70e-01	-0.098900	6.91e-01
SUMOylation	167	2.84e-02	-0.098300	6.86e-02
TICAM1, RIP1-mediated IKK complex recruitment	19	4.59e-01	-0.098100	5.89e-01
CLEC7A/inflammasome pathway	6	6.78e-01	-0.098000	7.71e-01
TICAM1-dependent activation of IRF3/IRF7	13	5.41e-01	-0.098000	6.67e-01
RHO GTPase cycle	411	6.69e-04	-0.097800	3.13e-03
Defective C1GALT1C1 causes TNPS	10	5.94e-01	0.097200	7.11e-01
Arachidonate metabolism	47	2.49e-01	-0.097200	3.79e-01
Keratan sulfate biosynthesis	20	4.53e-01	-0.096900	5.84e-01
Surfactant metabolism	20	4.53e-01	-0.096800	5.84e-01
Interleukin-20 family signaling	17	4.90e-01	0.096600	6.18e-01
NRAGE signals death through JNK	52	2.30e-01	-0.096200	3.56e-01
SUMOylation of immune response proteins	12	5.65e-01	-0.095900	6.87e-01
Regulation of HSF1-mediated heat shock response	79	1.41e-01	-0.095800	2.45e-01
RNA polymerase II transcribes snRNA genes	71	1.64e-01	-0.095500	2.75e-01
Interleukin-9 signaling	8	6.40e-01	0.095500	7.41e-01
Regulation of FOXO transcriptional activity by acetylation	10	6.02e-01	-0.095300	7.13e-01
Processing of DNA double-strand break ends	69	1.72e-01	-0.095000	2.86e-01
DAG and IP3 signaling	34	3.39e-01	-0.094700	4.75e-01
Striated Muscle Contraction	27	3.95e-01	0.094600	5.27e-01
Resolution of Sister Chromatid Cohesion	116	7.93e-02	-0.094300	1.57e-01
Inhibition of Signaling by Overexpressed EGFR	5	7.15e-01	-0.094300	7.96e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	7.15e-01	-0.094300	7.96e-01
CDC42 GTPase cycle	140	5.52e-02	-0.093900	1.17e-01
EGFR interacts with phospholipase C-gamma	6	6.91e-01	-0.093800	7.81e-01
FOXO-mediated transcription of cell cycle genes	14	5.45e-01	-0.093400	6.70e-01
HDR through Homologous Recombination (HRR)	68	1.83e-01	-0.093300	2.98e-01
Regulation of NPAS4 gene expression	11	5.92e-01	0.093300	7.10e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	6.69e-01	-0.093300	7.66e-01
Circadian Clock	67	1.88e-01	-0.093000	3.04e-01
TRAF6 mediated NF-kB activation	23	4.42e-01	-0.092600	5.74e-01
Epigenetic regulation of gene expression	264	1.00e-02	-0.092100	2.98e-02
Mitotic Spindle Checkpoint	108	9.87e-02	-0.092000	1.87e-01
Ion channel transport	141	6.02e-02	-0.091700	1.26e-01
RUNX3 regulates WNT signaling	8	6.54e-01	0.091600	7.52e-01
EML4 and NUDC in mitotic spindle formation	107	1.02e-01	-0.091400	1.92e-01
Regulation of TP53 Activity through Phosphorylation	88	1.39e-01	-0.091300	2.42e-01
Nuclear Envelope Breakdown	53	2.51e-01	-0.091200	3.80e-01
Activation of NMDA receptors and postsynaptic events	74	1.75e-01	-0.091200	2.89e-01
PI-3K cascade:FGFR4	11	6.01e-01	0.091100	7.12e-01
Adenylate cyclase activating pathway	8	6.56e-01	-0.091000	7.54e-01
Fatty acyl-CoA biosynthesis	35	3.52e-01	-0.090800	4.88e-01
Signaling by Erythropoietin	24	4.41e-01	-0.090800	5.74e-01
Elastic fibre formation	33	3.68e-01	-0.090500	5.05e-01
TRAF6 mediated IRF7 activation	15	5.46e-01	0.090100	6.70e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	3.19e-01	0.090000	4.52e-01
Diseases of DNA Double-Strand Break Repair	41	3.19e-01	0.090000	4.52e-01
Vitamin B2 (riboflavin) metabolism	6	7.04e-01	-0.089600	7.90e-01
Nuclear signaling by ERBB4	24	4.50e-01	-0.089200	5.81e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	6.83e-01	-0.089000	7.75e-01
Uptake and actions of bacterial toxins	27	4.25e-01	-0.088800	5.59e-01
CaM pathway	28	4.18e-01	-0.088500	5.52e-01
Calmodulin induced events	28	4.18e-01	-0.088500	5.52e-01
Nitric oxide stimulates guanylate cyclase	15	5.53e-01	0.088500	6.77e-01
Intraflagellar transport	47	2.97e-01	-0.088000	4.29e-01
FGFR2 ligand binding and activation	9	6.48e-01	0.088000	7.46e-01
SUMOylation of DNA replication proteins	46	3.03e-01	-0.087800	4.36e-01
Regulation of lipid metabolism by PPARalpha	107	1.19e-01	-0.087200	2.17e-01
Scavenging by Class A Receptors	12	6.01e-01	-0.087200	7.12e-01
RHO GTPases activate KTN1	11	6.17e-01	-0.087200	7.26e-01
Signaling by FGFR1 in disease	32	3.95e-01	0.086800	5.27e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	79	1.83e-01	-0.086600	2.98e-01
RHOBTB2 GTPase cycle	23	4.73e-01	-0.086400	6.01e-01
PPARA activates gene expression	105	1.28e-01	-0.086100	2.27e-01
Xenobiotics	12	6.07e-01	0.085900	7.17e-01
Deactivation of the beta-catenin transactivating complex	36	3.73e-01	-0.085800	5.10e-01
Plasma lipoprotein assembly	10	6.39e-01	-0.085700	7.41e-01
Synthesis of PA	31	4.15e-01	-0.084600	5.49e-01
RHOBTB GTPase Cycle	35	3.87e-01	-0.084400	5.21e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	5.85e-01	-0.084300	7.03e-01
Sensory perception of taste	22	4.95e-01	0.084100	6.21e-01
SHC1 events in ERBB4 signaling	10	6.47e-01	-0.083600	7.46e-01
Reproduction	86	1.81e-01	-0.083400	2.96e-01
RIPK1-mediated regulated necrosis	31	4.23e-01	-0.083100	5.57e-01
Regulation of necroptotic cell death	31	4.23e-01	-0.083100	5.57e-01
Cell junction organization	78	2.05e-01	-0.083000	3.25e-01
Activation of C3 and C5	7	7.06e-01	-0.082400	7.91e-01
Inwardly rectifying K+ channels	23	4.97e-01	-0.081800	6.23e-01
Activation of GABAB receptors	30	4.41e-01	-0.081200	5.74e-01
GABA B receptor activation	30	4.41e-01	-0.081200	5.74e-01
Recruitment of NuMA to mitotic centrosomes	88	1.89e-01	-0.081000	3.05e-01
Apoptotic cleavage of cellular proteins	35	4.07e-01	-0.080900	5.41e-01
Downstream signaling of activated FGFR3	17	5.66e-01	0.080400	6.87e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	3.31e-01	-0.080200	4.65e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	6.95e-01	0.080000	7.85e-01
Endosomal/Vacuolar pathway	12	6.32e-01	-0.079700	7.37e-01
Assembly of collagen fibrils and other multimeric structures	42	3.76e-01	-0.079000	5.12e-01
HDR through Single Strand Annealing (SSA)	37	4.07e-01	0.078800	5.40e-01
Caspase activation via Death Receptors in the presence of ligand	16	5.86e-01	0.078700	7.03e-01
Signaling by activated point mutants of FGFR1	5	7.61e-01	-0.078600	8.34e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	6.37e-01	-0.078600	7.40e-01
Norepinephrine Neurotransmitter Release Cycle	12	6.37e-01	0.078600	7.40e-01
FasL/ CD95L signaling	5	7.61e-01	0.078500	8.34e-01
Metabolism of non-coding RNA	53	3.24e-01	-0.078300	4.58e-01
snRNP Assembly	53	3.24e-01	-0.078300	4.58e-01
G alpha (q) signalling events	139	1.11e-01	-0.078200	2.05e-01
FGFR1c ligand binding and activation	8	7.02e-01	-0.078100	7.89e-01
Presynaptic depolarization and calcium channel opening	8	7.02e-01	0.078000	7.89e-01
NCAM1 interactions	26	4.92e-01	-0.077900	6.19e-01
Homologous DNA Pairing and Strand Exchange	43	3.78e-01	0.077700	5.14e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	7.22e-01	-0.077700	8.03e-01
Phospholipase C-mediated cascade: FGFR1	8	7.06e-01	-0.077100	7.91e-01
MECP2 regulates transcription factors	5	7.66e-01	0.076800	8.36e-01
Transport of Mature Transcript to Cytoplasm	81	2.32e-01	-0.076800	3.58e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	5.63e-01	0.076700	6.85e-01
Synthesis of PIPs at the ER membrane	5	7.67e-01	0.076600	8.37e-01
Synthesis of bile acids and bile salts	26	4.99e-01	-0.076600	6.25e-01
Stimuli-sensing channels	80	2.37e-01	-0.076500	3.64e-01
G alpha (12/13) signalling events	68	2.77e-01	-0.076300	4.10e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	2.09e-01	-0.076200	3.29e-01
Amplification of signal from the kinetochores	91	2.09e-01	-0.076200	3.29e-01
HDL remodeling	6	7.47e-01	0.076100	8.22e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	4.06e-01	0.075900	5.40e-01
HSF1-dependent transactivation	30	4.72e-01	-0.075900	6.00e-01
FGFR1 ligand binding and activation	10	6.79e-01	-0.075700	7.71e-01
L1CAM interactions	101	1.89e-01	-0.075700	3.05e-01
CD209 (DC-SIGN) signaling	20	5.59e-01	-0.075600	6.81e-01
G2/M DNA damage checkpoint	66	2.89e-01	-0.075500	4.22e-01
Nephrin family interactions	20	5.60e-01	0.075300	6.82e-01
Lewis blood group biosynthesis	13	6.40e-01	-0.075000	7.41e-01
Synthesis of UDP-N-acetyl-glucosamine	8	7.14e-01	-0.074900	7.96e-01
Regulation of endogenous retroelements	93	2.14e-01	-0.074500	3.36e-01
Molecules associated with elastic fibres	26	5.13e-01	-0.074200	6.35e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	4.12e-01	-0.074000	5.46e-01
SHC-mediated cascade:FGFR4	11	6.71e-01	-0.073900	7.67e-01
RND1 GTPase cycle	36	4.45e-01	-0.073600	5.77e-01
IRS-mediated signalling	35	4.52e-01	-0.073500	5.84e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	5.70e-01	-0.073300	6.91e-01
Diseases of DNA repair	51	3.68e-01	0.072800	5.05e-01
Antiviral mechanism by IFN-stimulated genes	140	1.38e-01	-0.072600	2.42e-01
Signaling by FGFR in disease	52	3.68e-01	-0.072200	5.05e-01
IGF1R signaling cascade	37	4.49e-01	-0.072000	5.81e-01
Repression of WNT target genes	14	6.44e-01	-0.071400	7.45e-01
Defective factor IX causes hemophilia B	6	7.62e-01	0.071200	8.34e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.83e-01	-0.071200	7.74e-01
Glutamate Neurotransmitter Release Cycle	19	5.92e-01	0.071000	7.10e-01
GAB1 signalosome	14	6.47e-01	-0.070600	7.46e-01
Signaling by NTRK3 (TRKC)	15	6.36e-01	-0.070500	7.40e-01
Interleukin-23 signaling	7	7.49e-01	-0.069900	8.24e-01
Activation of G protein gated Potassium channels	19	5.98e-01	-0.069800	7.11e-01
G protein gated Potassium channels	19	5.98e-01	-0.069800	7.11e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	19	5.98e-01	-0.069800	7.11e-01
Interleukin-37 signaling	19	6.00e-01	-0.069500	7.12e-01
Insulin processing	19	6.02e-01	0.069000	7.13e-01
Signaling by cytosolic FGFR1 fusion mutants	18	6.13e-01	0.068900	7.23e-01
Transcriptional Regulation by VENTX	39	4.58e-01	-0.068700	5.88e-01
Mitotic Prometaphase	193	1.06e-01	-0.067400	1.98e-01
Wax and plasmalogen biosynthesis	5	7.96e-01	-0.066900	8.54e-01
Visual phototransduction	61	3.67e-01	-0.066800	5.04e-01
Fertilization	13	6.78e-01	0.066600	7.71e-01
Inactivation, recovery and regulation of the phototransduction cascade	26	5.60e-01	0.066100	6.82e-01
LGI-ADAM interactions	9	7.33e-01	-0.065600	8.13e-01
Factors involved in megakaryocyte development and platelet production	129	1.98e-01	-0.065600	3.17e-01
Beta-oxidation of very long chain fatty acids	11	7.09e-01	-0.065100	7.92e-01
RHO GTPases activate CIT	18	6.33e-01	-0.064900	7.38e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	6.75e-01	-0.064700	7.69e-01
Activation of Ca-permeable Kainate Receptor	9	7.38e-01	0.064500	8.16e-01
Ionotropic activity of kainate receptors	9	7.38e-01	0.064500	8.16e-01
GPCR downstream signalling	399	2.71e-02	-0.064500	6.58e-02
Acyl chain remodelling of PG	11	7.13e-01	-0.064100	7.96e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	6.21e-01	0.063900	7.28e-01
Cell-Cell communication	110	2.48e-01	-0.063800	3.78e-01
Tryptophan catabolism	12	7.04e-01	-0.063400	7.90e-01
RAC1 GTPase cycle	172	1.52e-01	-0.063400	2.58e-01
Sodium/Proton exchangers	7	7.72e-01	-0.063200	8.39e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	5.02e-01	-0.063000	6.26e-01
EGFR Transactivation by Gastrin	7	7.73e-01	0.062900	8.39e-01
IkBA variant leads to EDA-ID	7	7.73e-01	0.062800	8.39e-01
Ca2+ activated K+ channels	6	7.90e-01	-0.062700	8.51e-01
CYP2E1 reactions	5	8.12e-01	0.061400	8.70e-01
G alpha (i) signalling events	196	1.41e-01	-0.061000	2.44e-01
Interactions of Vpr with host cellular proteins	37	5.22e-01	-0.060800	6.46e-01
DAP12 signaling	28	5.79e-01	-0.060600	6.97e-01
Deadenylation of mRNA	22	6.24e-01	-0.060400	7.30e-01
Ion homeostasis	42	4.99e-01	-0.060200	6.25e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	5.57e-01	-0.060100	6.80e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	6.99e-01	-0.059700	7.87e-01
FRS-mediated FGFR3 signaling	12	7.22e-01	0.059300	8.03e-01
Gain-of-function MRAS complexes activate RAF signaling	8	7.72e-01	0.059200	8.39e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	7.72e-01	0.059200	8.39e-01
Signaling by MRAS-complex mutants	8	7.72e-01	0.059200	8.39e-01
Defective GALNT12 causes CRCS1	9	7.59e-01	0.059000	8.33e-01
Attenuation phase	23	6.24e-01	-0.059000	7.30e-01
Heme signaling	45	4.97e-01	0.058600	6.23e-01
Cobalamin (Cbl) metabolism	7	7.88e-01	0.058600	8.49e-01
Regulation of RUNX1 Expression and Activity	18	6.68e-01	0.058500	7.65e-01
Defective B3GALTL causes PpS	27	5.99e-01	0.058400	7.11e-01
Serine biosynthesis	8	7.75e-01	0.058400	8.39e-01
GABA synthesis, release, reuptake and degradation	11	7.38e-01	-0.058300	8.16e-01
Regulation of IFNA/IFNB signaling	12	7.26e-01	-0.058300	8.06e-01
tRNA modification in the nucleus and cytosol	43	5.08e-01	-0.058300	6.32e-01
Mitochondrial Uncoupling	6	8.05e-01	0.058200	8.64e-01
Alpha-protein kinase 1 signaling pathway	11	7.39e-01	-0.057900	8.17e-01
GRB2 events in EGFR signaling	10	7.52e-01	-0.057700	8.26e-01
Apoptotic cleavage of cell adhesion proteins	8	7.78e-01	0.057500	8.41e-01
Aspirin ADME	15	7.01e-01	0.057300	7.88e-01
Class B/2 (Secretin family receptors)	57	4.55e-01	-0.057200	5.84e-01
Signaling by NTRK2 (TRKB)	20	6.58e-01	-0.057200	7.56e-01
Protein-protein interactions at synapses	58	4.55e-01	-0.056700	5.84e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	4.91e-01	-0.056300	6.18e-01
Neurotransmitter receptors and postsynaptic signal transmission	139	2.52e-01	-0.056200	3.82e-01
Gene expression (Transcription)	1404	4.16e-04	-0.056200	2.06e-03
Transcriptional Regulation by MECP2	49	5.00e-01	-0.055600	6.25e-01
E2F-enabled inhibition of pre-replication complex formation	9	7.75e-01	0.055000	8.39e-01
Centrosome maturation	81	3.94e-01	-0.054800	5.26e-01
Recruitment of mitotic centrosome proteins and complexes	81	3.94e-01	-0.054800	5.26e-01
Signaling by GPCR	446	4.73e-02	-0.054800	1.03e-01
Interleukin-7 signaling	21	6.64e-01	0.054700	7.62e-01
Sialic acid metabolism	28	6.17e-01	-0.054500	7.27e-01
Kidney development	17	6.97e-01	0.054500	7.86e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	7.00e-01	-0.054000	7.87e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	5.99e-01	0.053700	7.11e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	5.99e-01	0.053700	7.11e-01
Mitotic Telophase/Cytokinesis	13	7.38e-01	0.053600	8.16e-01
Downstream signaling of activated FGFR4	18	6.97e-01	0.053000	7.86e-01
PTK6 promotes HIF1A stabilization	6	8.22e-01	0.052900	8.77e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	4.38e-01	-0.052900	5.73e-01
Transcriptional Regulation by NPAS4	27	6.35e-01	-0.052700	7.39e-01
Prolactin receptor signaling	11	7.62e-01	-0.052700	8.34e-01
Signaling by ALK	24	6.57e-01	-0.052300	7.55e-01
Sensory processing of sound	58	4.92e-01	-0.052100	6.19e-01
Nuclear Receptor transcription pathway	38	5.78e-01	-0.052100	6.97e-01
TNFR1-induced proapoptotic signaling	24	6.60e-01	0.052000	7.57e-01
SLC transporter disorders	76	4.36e-01	-0.051600	5.72e-01
RNA Polymerase II Transcription	1197	2.66e-03	-0.051600	1.01e-02
Defects of platelet adhesion to exposed collagen	7	8.14e-01	0.051400	8.70e-01
Potassium Channels	64	4.77e-01	0.051400	6.05e-01
Synthesis of PI	5	8.44e-01	-0.050800	8.91e-01
ZBP1(DAI) mediated induction of type I IFNs	20	6.96e-01	0.050500	7.85e-01
Regulation of Expression and Function of Type II Classical Cadherins	24	6.70e-01	0.050200	7.66e-01
Regulation of Homotypic Cell-Cell Adhesion	24	6.70e-01	0.050200	7.66e-01
Intrinsic Pathway of Fibrin Clot Formation	15	7.37e-01	0.050100	8.16e-01
O-glycosylation of TSR domain-containing proteins	28	6.47e-01	0.050000	7.46e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	6.25e-01	0.050000	7.30e-01
Androgen biosynthesis	5	8.47e-01	0.049900	8.93e-01
Neurexins and neuroligins	38	5.98e-01	-0.049400	7.11e-01
IRS-related events triggered by IGF1R	36	6.11e-01	-0.049000	7.21e-01
Cilium Assembly	187	2.49e-01	-0.048800	3.79e-01
Interleukin-6 signaling	11	7.81e-01	-0.048500	8.43e-01
Regulation of insulin secretion	63	5.06e-01	-0.048400	6.30e-01
CREB phosphorylation	7	8.25e-01	0.048400	8.78e-01
Signaling by ERBB2 KD Mutants	20	7.09e-01	0.048200	7.92e-01
Glycerophospholipid catabolism	7	8.26e-01	0.048100	8.79e-01
Generic Transcription Pathway	1079	7.84e-03	-0.047900	2.47e-02
Biosynthesis of specialized proresolving mediators (SPMs)	16	7.42e-01	-0.047600	8.18e-01
Myogenesis	20	7.14e-01	-0.047300	7.96e-01
Assembly and cell surface presentation of NMDA receptors	34	6.34e-01	-0.047200	7.38e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	6.85e-01	0.046800	7.76e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	8.30e-01	0.046800	8.81e-01
Sensory processing of sound by inner hair cells of the cochlea	54	5.57e-01	-0.046200	6.80e-01
Defective RIPK1-mediated regulated necrosis	7	8.33e-01	-0.045900	8.83e-01
DAP12 interactions	39	6.21e-01	-0.045700	7.28e-01
Transmission across Chemical Synapses	183	2.89e-01	-0.045400	4.22e-01
TRAF3-dependent IRF activation pathway	13	7.77e-01	0.045400	8.40e-01
Export of Viral Ribonucleoproteins from Nucleus	33	6.53e-01	0.045200	7.52e-01
Regulation of CDH19 Expression and Function	6	8.51e-01	-0.044200	8.97e-01
HDR through MMEJ (alt-NHEJ)	12	7.91e-01	0.044100	8.51e-01
Acyl chain remodelling of PC	19	7.40e-01	-0.043900	8.17e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	8.20e-01	-0.043900	8.75e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	16	7.62e-01	0.043700	8.34e-01
Interferon Signaling	240	2.44e-01	-0.043700	3.73e-01
Long-term potentiation	18	7.49e-01	0.043600	8.24e-01
Crosslinking of collagen fibrils	13	7.88e-01	-0.043000	8.49e-01
Interleukin-15 signaling	14	7.81e-01	0.042900	8.43e-01
Transport of bile salts and organic acids, metal ions and amine compounds	53	5.96e-01	-0.042100	7.11e-01
Laminin interactions	26	7.15e-01	-0.041300	7.96e-01
Interferon alpha/beta signaling	64	5.68e-01	0.041200	6.90e-01
Growth hormone receptor signaling	20	7.50e-01	-0.041200	8.24e-01
NS1 Mediated Effects on Host Pathways	40	6.56e-01	0.040800	7.54e-01
MECP2 regulates neuronal receptors and channels	14	7.92e-01	-0.040700	8.52e-01
MECP2 regulates transcription of neuronal ligands	5	8.75e-01	-0.040600	9.16e-01
Signaling by ERBB2 TMD/JMD mutants	17	7.74e-01	-0.040200	8.39e-01
SHC-mediated cascade:FGFR3	10	8.27e-01	-0.039900	8.80e-01
Bile acid and bile salt metabolism	30	7.07e-01	-0.039600	7.92e-01
O-linked glycosylation of mucins	47	6.39e-01	-0.039500	7.41e-01
Signaling by LTK	10	8.29e-01	-0.039500	8.80e-01
BBSome-mediated cargo-targeting to cilium	23	7.46e-01	-0.039000	8.22e-01
Formation of WDR5-containing histone-modifying complexes	42	6.62e-01	-0.038900	7.60e-01
Nuclear Pore Complex (NPC) Disassembly	36	6.86e-01	-0.038900	7.77e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	7.88e-01	0.038800	8.49e-01
Cardiac conduction	89	5.28e-01	0.038700	6.53e-01
Defects in cobalamin (B12) metabolism	13	8.10e-01	-0.038600	8.68e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	6.04e-01	-0.038400	7.14e-01
Glycosphingolipid biosynthesis	15	7.97e-01	-0.038400	8.55e-01
FGFR4 ligand binding and activation	5	8.83e-01	0.038000	9.21e-01
Postmitotic nuclear pore complex (NPC) reformation	27	7.37e-01	-0.037300	8.16e-01
Dissolution of Fibrin Clot	12	8.24e-01	0.037000	8.78e-01
TNFR1-induced NF-kappa-B signaling pathway	32	7.19e-01	-0.036800	8.00e-01
Tight junction interactions	17	7.93e-01	0.036700	8.52e-01
Signaling by ERBB4	45	6.71e-01	-0.036600	7.66e-01
Regulation of NFE2L2 gene expression	8	8.58e-01	0.036500	9.01e-01
Transport of the SLBP independent Mature mRNA	35	7.08e-01	0.036500	7.92e-01
Peptide ligand-binding receptors	102	5.32e-01	0.035800	6.58e-01
FGFR1 mutant receptor activation	25	7.58e-01	0.035700	8.32e-01
Lysosphingolipid and LPA receptors	11	8.38e-01	-0.035600	8.87e-01
STAT3 nuclear events downstream of ALK signaling	11	8.39e-01	-0.035400	8.87e-01
Adherens junctions interactions	38	7.07e-01	-0.035200	7.92e-01
Downstream signaling of activated FGFR1	22	7.76e-01	0.035000	8.40e-01
Regulation of PLK1 Activity at G2/M Transition	87	5.75e-01	-0.034800	6.95e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	7.65e-01	0.034600	8.36e-01
ARMS-mediated activation	6	8.84e-01	0.034300	9.21e-01
AURKA Activation by TPX2	72	6.17e-01	-0.034100	7.26e-01
Regulation of gene expression in beta cells	8	8.70e-01	0.033300	9.12e-01
RIP-mediated NFkB activation via ZBP1	17	8.14e-01	0.033000	8.70e-01
Signaling by PDGFRA extracellular domain mutants	12	8.44e-01	0.032700	8.91e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.44e-01	0.032700	8.91e-01
P2Y receptors	10	8.59e-01	-0.032500	9.01e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	7.74e-01	0.032500	8.39e-01
CHL1 interactions	8	8.75e-01	0.032000	9.16e-01
Nicotinate metabolism	27	7.73e-01	-0.032000	8.39e-01
Kinesins	51	6.93e-01	-0.032000	7.82e-01
Lysine catabolism	11	8.56e-01	-0.031700	8.99e-01
TRAIL signaling	8	8.78e-01	0.031400	9.17e-01
Interleukin-2 family signaling	38	7.38e-01	-0.031300	8.16e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	7.23e-01	-0.031300	8.03e-01
Aspartate and asparagine metabolism	9	8.71e-01	0.031200	9.12e-01
Regulation of IFNG signaling	14	8.41e-01	0.031100	8.88e-01
Interactions of Rev with host cellular proteins	37	7.44e-01	-0.031000	8.20e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	7.66e-01	0.030400	8.36e-01
SUMOylation of DNA damage response and repair proteins	77	6.45e-01	-0.030300	7.46e-01
Biosynthesis of DHA-derived SPMs	14	8.44e-01	0.030300	8.91e-01
Collagen chain trimerization	27	7.88e-01	0.029900	8.49e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	6.99e-01	-0.029700	7.87e-01
Miscellaneous transport and binding events	20	8.19e-01	-0.029600	8.75e-01
Loss of Nlp from mitotic centrosomes	69	6.72e-01	-0.029400	7.67e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	6.72e-01	-0.029400	7.67e-01
WNT ligand biogenesis and trafficking	20	8.23e-01	-0.028900	8.78e-01
O-linked glycosylation	85	6.48e-01	-0.028700	7.46e-01
Nuclear import of Rev protein	34	7.72e-01	-0.028700	8.39e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	7.74e-01	0.028500	8.39e-01
Gamma-carboxylation of protein precursors	6	9.04e-01	-0.028500	9.36e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	8.67e-01	-0.027900	9.09e-01
FRS-mediated FGFR1 signaling	15	8.52e-01	-0.027900	8.97e-01
RHOBTB1 GTPase cycle	23	8.17e-01	-0.027800	8.73e-01
SHC-related events triggered by IGF1R	7	8.99e-01	-0.027700	9.32e-01
Rev-mediated nuclear export of HIV RNA	35	7.77e-01	-0.027600	8.40e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	8.53e-01	0.027600	8.97e-01
NrCAM interactions	6	9.07e-01	-0.027500	9.39e-01
Glucuronidation	8	8.94e-01	0.027100	9.28e-01
Regulation of beta-cell development	22	8.34e-01	-0.025900	8.83e-01
Neuronal System	270	4.65e-01	-0.025800	5.94e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	9.13e-01	-0.025700	9.41e-01
TGFBR1 KD Mutants in Cancer	6	9.13e-01	-0.025700	9.41e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	8.12e-01	-0.025100	8.70e-01
NOTCH2 intracellular domain regulates transcription	11	8.87e-01	0.024800	9.22e-01
Platelet Adhesion to exposed collagen	15	8.69e-01	0.024600	9.11e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	8.83e-01	0.024400	9.21e-01
Resolution of D-Loop Structures	35	8.07e-01	0.023900	8.65e-01
FRS-mediated FGFR4 signaling	13	8.87e-01	0.022900	9.22e-01
Synthesis of very long-chain fatty acyl-CoAs	22	8.53e-01	-0.022900	8.97e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	9.30e-01	-0.022600	9.54e-01
PI-3K cascade:FGFR1	13	8.90e-01	0.022100	9.26e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	18	8.76e-01	0.021200	9.16e-01
Blood group systems biosynthesis	17	8.80e-01	-0.021200	9.18e-01
Signaling by Hippo	18	8.77e-01	0.021100	9.16e-01
Vitamin C (ascorbate) metabolism	8	9.18e-01	-0.021000	9.44e-01
Netrin-1 signaling	35	8.30e-01	-0.021000	8.81e-01
Transport of the SLBP Dependant Mature mRNA	36	8.28e-01	0.021000	8.80e-01
RUNX3 regulates CDKN1A transcription	7	9.25e-01	0.020700	9.49e-01
Acyl chain remodelling of PI	10	9.12e-01	-0.020100	9.40e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	8.27e-01	-0.019500	8.79e-01
Phase 3 - rapid repolarisation	6	9.37e-01	-0.018700	9.60e-01
Interleukin-4 and Interleukin-13 signaling	92	7.63e-01	-0.018200	8.35e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	9.40e-01	0.017600	9.62e-01
Signaling by BMP	23	8.86e-01	-0.017300	9.22e-01
EPHA-mediated growth cone collapse	21	8.93e-01	-0.017000	9.27e-01
Phospholipase C-mediated cascade; FGFR4	6	9.45e-01	0.016400	9.64e-01
Synthesis of PIPs at the plasma membrane	52	8.38e-01	-0.016400	8.87e-01
Signaling by FLT3 ITD and TKD mutants	15	9.15e-01	0.015900	9.42e-01
TRP channels	22	9.01e-01	0.015300	9.34e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	9.53e-01	0.015200	9.69e-01
ISG15 antiviral mechanism	72	8.29e-01	-0.014800	8.80e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	9.10e-01	0.014600	9.39e-01
Trafficking of AMPA receptors	20	9.10e-01	0.014600	9.39e-01
Signaling by ERBB2 in Cancer	21	9.08e-01	0.014600	9.39e-01
Interleukin receptor SHC signaling	23	9.06e-01	0.014200	9.38e-01
Cell-cell junction organization	57	8.54e-01	-0.014100	8.97e-01
Signaling by ERBB2 ECD mutants	15	9.25e-01	0.014100	9.49e-01
Regulation of CDH11 Expression and Function	22	9.11e-01	0.013800	9.39e-01
ERBB2 Activates PTK6 Signaling	8	9.46e-01	0.013800	9.65e-01
Acetylcholine Neurotransmitter Release Cycle	10	9.40e-01	-0.013700	9.62e-01
Regulation of CDH11 function	9	9.44e-01	-0.013500	9.64e-01
Activated NTRK2 signals through FRS2 and FRS3	8	9.48e-01	0.013400	9.65e-01
SUMOylation of ubiquitinylation proteins	39	8.91e-01	-0.012600	9.26e-01
FLT3 signaling in disease	27	9.11e-01	-0.012500	9.39e-01
Cellular hexose transport	15	9.34e-01	-0.012300	9.57e-01
Diseases associated with O-glycosylation of proteins	50	8.81e-01	-0.012300	9.19e-01
Formation of Fibrin Clot (Clotting Cascade)	26	9.14e-01	-0.012300	9.41e-01
ROBO receptors bind AKAP5	7	9.58e-01	-0.011400	9.72e-01
GRB2 events in ERBB2 signaling	11	9.48e-01	-0.011300	9.65e-01
TRIF-mediated programmed cell death	9	9.55e-01	-0.010800	9.71e-01
Triglyceride biosynthesis	9	9.57e-01	0.010500	9.71e-01
Loss of Function of SMAD2/3 in Cancer	7	9.64e-01	0.009950	9.75e-01
Phase 2 - plateau phase	11	9.58e-01	0.009220	9.72e-01
Dopamine Neurotransmitter Release Cycle	18	9.51e-01	-0.008310	9.68e-01
Formation of the nephric duct	8	9.68e-01	-0.008200	9.78e-01
Nicotinamide salvaging	16	9.57e-01	0.007850	9.71e-01
Ca2+ pathway	58	9.23e-01	-0.007300	9.49e-01
Regulation of MECP2 expression and activity	29	9.46e-01	-0.007210	9.65e-01
Acyl chain remodelling of PS	14	9.63e-01	-0.007180	9.75e-01
Interferon gamma signaling	90	9.08e-01	0.007030	9.39e-01
RHO GTPases Activate ROCKs	18	9.59e-01	-0.006980	9.72e-01
GABA receptor activation	36	9.42e-01	0.006970	9.63e-01
PKMTs methylate histone lysines	43	9.41e-01	0.006510	9.62e-01
Neurotransmitter release cycle	35	9.48e-01	-0.006420	9.65e-01
Netrin mediated repulsion signals	5	9.82e-01	-0.005680	9.89e-01
FGFRL1 modulation of FGFR1 signaling	7	9.81e-01	-0.005220	9.88e-01
Nephron development	5	9.87e-01	-0.004340	9.91e-01
Cytochrome P450 - arranged by substrate type	39	9.64e-01	0.004230	9.75e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	9.76e-01	0.004150	9.85e-01
Class A/1 (Rhodopsin-like receptors)	177	9.27e-01	0.004000	9.51e-01
Serotonin Neurotransmitter Release Cycle	13	9.82e-01	-0.003610	9.89e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	9.89e-01	0.003580	9.92e-01
Maple Syrup Urine Disease	5	9.89e-01	0.003580	9.92e-01
Constitutive Signaling by EGFRvIII	14	9.84e-01	0.003180	9.89e-01
Signaling by EGFRvIII in Cancer	14	9.84e-01	0.003180	9.89e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	9.79e-01	-0.003060	9.87e-01
Anchoring of the basal body to the plasma membrane	97	9.59e-01	0.003020	9.72e-01
GPCR ligand binding	245	9.39e-01	-0.002840	9.61e-01
Vpr-mediated nuclear import of PICs	34	9.78e-01	0.002740	9.86e-01
Ion transport by P-type ATPases	44	9.76e-01	0.002610	9.85e-01
PI Metabolism	79	9.71e-01	0.002340	9.81e-01
Muscle contraction	145	9.64e-01	-0.002180	9.75e-01
Activation of Matrix Metalloproteinases	22	9.87e-01	-0.001970	9.91e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	9.91e-01	0.001660	9.93e-01
Termination of O-glycan biosynthesis	16	9.92e-01	0.001500	9.93e-01
NCAM signaling for neurite out-growth	47	9.90e-01	-0.001040	9.93e-01
Neurotransmitter clearance	5	9.97e-01	-0.000851	9.98e-01
RORA activates gene expression	18	9.96e-01	-0.000732	9.97e-01
SUMOylation of SUMOylation proteins	35	9.98e-01	0.000242	9.98e-01

---

Detailed Gene set reports

Modulation by Mtb of host immune system

set	Modulation by Mtb of host immune system
setSize	7
pANOVA	0.000174
s.dist	-0.819
p.adjustANOVA	0.000946

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRC1	-10462
UBA52	-10332
TLR2	-9374
RPS27A	-8754
UBC	-8748
B2M	-7647
UBB	-6271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRC1	-10462
UBA52	-10332
TLR2	-9374
RPS27A	-8754
UBC	-8748
B2M	-7647
UBB	-6271

---

Peptide chain elongation

set	Peptide chain elongation
setSize	87
pANOVA	1.13e-39
s.dist	-0.816
p.adjustANOVA	1.08e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
EEF2	-10571
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
EEF1A1	-10144

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
EEF2	-10571
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
EEF1A1	-10144
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
RPL26L1	-6585
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
RPS27L	697
RPL9	3863
RPS26	9966

---

Maturation of spike protein_9683686

set	Maturation of spike protein_9683686
setSize	5
pANOVA	0.00177
s.dist	-0.807
p.adjustANOVA	0.00715

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKCSH	-9570
GANAB	-9192
CANX	-8726
MGAT1	-8705
MOGS	-7159

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKCSH	-9570
GANAB	-9192
CANX	-8726
MGAT1	-8705
MOGS	-7159

---

Viral mRNA Translation

set	Viral mRNA Translation
setSize	87
pANOVA	9.11e-39
s.dist	-0.806
p.adjustANOVA	7.98e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
GRSF1	-6820
RPL26L1	-6585
RPL36A	-5184
RPSA	-5038
DNAJC3	-4626
RPL39L	-3915
RPS27L	697
RPL9	3863
RPS26	9966

---

Formation of ATP by chemiosmotic coupling

set	Formation of ATP by chemiosmotic coupling
setSize	20
pANOVA	6.05e-10
s.dist	-0.799
p.adjustANOVA	7.88e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5F1B	-10701
ATP5F1A	-10570
ATP5MC2	-10564
ATP5MC3	-10489
ATP5PF	-10427
ATP5MG	-10130
ATP5F1E	-10121
ATP5PO	-10112
ATP5MK	-9924
ATP5MF	-9836
ATP5MJ	-9608
ATP5ME	-9402
ATP5PB	-8223
ATP5MC1	-8110
ATP5F1D	-7706
ATP5PD	-7061
ATP5F1C	-6923
MT-ATP8	-4402
MT-ATP6	-3871
DMAC2L	-3285

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5F1B	-10701
ATP5F1A	-10570
ATP5MC2	-10564
ATP5MC3	-10489
ATP5PF	-10427
ATP5MG	-10130
ATP5F1E	-10121
ATP5PO	-10112
ATP5MK	-9924
ATP5MF	-9836
ATP5MJ	-9608
ATP5ME	-9402
ATP5PB	-8223
ATP5MC1	-8110
ATP5F1D	-7706
ATP5PD	-7061
ATP5F1C	-6923
MT-ATP8	-4402
MT-ATP6	-3871
DMAC2L	-3285

---

Eukaryotic Translation Elongation

set	Eukaryotic Translation Elongation
setSize	92
pANOVA	5.11e-40
s.dist	-0.797
p.adjustANOVA	5.19e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
EEF2	-10571
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
EEF1A1P5	-10175
RPS4X	-10162

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
EEF2	-10571
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
EEF1A1P5	-10175
RPS4X	-10162
EEF1A1	-10144
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
EEF1B2	-9370
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
EEF1D	-8316
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
EEF1G	-7679
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
RPL26L1	-6585
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
RPS27L	697
RPL9	3863
RPS26	9966
EEF1A2	10938

---

Formation of a pool of free 40S subunits

set	Formation of a pool of free 40S subunits
setSize	99
pANOVA	7.17e-42
s.dist	-0.787
p.adjustANOVA	9.21e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EIF3L	-9713
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF3D	-9263
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
RPL14	-8455
EIF3B	-8402
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
EIF3H	-7626
RPL6	-7578
EIF3M	-7487
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
EIF3E	-6765
RPL26L1	-6585
EIF3C	-5490
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
EIF3A	-1312
EIF3J	294
EIF1AX	539
RPS27L	697
RPL9	3863
RPS26	9966

---

SARS-CoV-1 modulates host translation machinery

set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	3.17e-16
s.dist	-0.786
p.adjustANOVA	8.47e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
EEF1A1	-10144
RPS11	-10105
RPS15	-10068
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPS10	-9910
RPS25	-9805
RPS15A	-9793
RPS3	-9754
RPS18	-9326

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
EEF1A1	-10144
RPS11	-10105
RPS15	-10068
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPS10	-9910
RPS25	-9805
RPS15A	-9793
RPS3	-9754
RPS18	-9326
RPS2	-9203
RPS20	-9133
RPS6	-9022
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPS24	-8227
RPS4Y1	-8159
RPS14	-7756
HNRNPA1	-7743
RPS3A	-7225
RPS5	-7123
RPSA	-5038
RPS27L	697
RPS26	9966

---

Eukaryotic Translation Termination

set	Eukaryotic Translation Termination
setSize	91
pANOVA	3.33e-38
s.dist	-0.782
p.adjustANOVA	2.68e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
TRMT112	-10260
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
TRMT112	-10260
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
APEH	-9976
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
RPL26L1	-6585
ETF1	-5979
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
N6AMT1	-819
RPS27L	697
GSPT2	883
RPL9	3863
GSPT1	3980
RPS26	9966

---

Glycosphingolipid transport

set	Glycosphingolipid transport
setSize	7
pANOVA	0.000407
s.dist	-0.772
p.adjustANOVA	0.00204

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARF1	-10398
CPTP	-10224
GLTP	-10057
CLN3	-8908
ESYT1	-7596
ESYT2	-6294
PLEKHA8	-4466

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARF1	-10398
CPTP	-10224
GLTP	-10057
CLN3	-8908
ESYT1	-7596
ESYT2	-6294
PLEKHA8	-4466

---

Selenocysteine synthesis

set	Selenocysteine synthesis
setSize	91
pANOVA	8.71e-37
s.dist	-0.767
p.adjustANOVA	6.21e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EEFSEC	-9700
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
SARS1	-7477
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
RPL26L1	-6585
SEPHS2	-6489
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
RPS27L	697
RPL9	3863
SEPSECS	4289
SECISBP2	4932
PSTK	7423
RPS26	9966

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	93
pANOVA	2.12e-37
s.dist	-0.765
p.adjustANOVA	1.57e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
PABPC1	-9847
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
UPF1	-6634
RPL26L1	-6585
ETF1	-5979
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
NCBP2	-837
RPS27L	697
GSPT2	883
RPL9	3863
GSPT1	3980
NCBP1	6089
RPS26	9966

---

Sulfide oxidation to sulfate

set	Sulfide oxidation to sulfate
setSize	5
pANOVA	0.00328
s.dist	-0.759
p.adjustANOVA	0.0121

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC25A10	-10245
TST	-10122
ETHE1	-9999
SUOX	-6688
TSTD1	-3658

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC25A10	-10245
TST	-10122
ETHE1	-9999
SUOX	-6688
TSTD1	-3658

---

SRP-dependent cotranslational protein targeting to membrane

set	SRP-dependent cotranslational protein targeting to membrane
setSize	110
pANOVA	6.1e-43
s.dist	-0.757
p.adjustANOVA	9.79e-41

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DDOST	-10746
RPL37A	-10648
RPN2	-10641
RPN1	-10592
SSR4	-10535
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
SEC61B	-10437
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
SEC61A1	-10323
RPL23	-10306
RPL15	-10283
SEC61G	-10250
RPS16	-10241

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DDOST	-10746
RPL37A	-10648
RPN2	-10641
RPN1	-10592
SSR4	-10535
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
SEC61B	-10437
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
SEC61A1	-10323
RPL23	-10306
RPL15	-10283
SEC61G	-10250
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
SRPRB	-9683
RPL7	-9677
SSR2	-9664
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
SRP14	-9195
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
SEC11A	-9089
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
SPCS1	-8605
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
SRPRA	-7888
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
SEC11C	-6882
RPL26L1	-6585
SRP72	-6328
TRAM1	-5624
RPL36A	-5184
RPSA	-5038
SPCS3	-4214
SSR3	-4032
SSR1	-4007
RPL39L	-3915
SPCS2	-3886
SRP9	-3790
SRP68	-1451
RPS27L	697
SRP19	3637
RPL9	3863
SRP54	6969
SEC61A2	7904
RPS26	9966

---

L13a-mediated translational silencing of Ceruloplasmin expression

set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	109
pANOVA	5.48e-42
s.dist	-0.751
p.adjustANOVA	7.54e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
PABPC1	-9847
RPL36	-9835
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
RPL14	-8455
EIF3B	-8402
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
EIF3H	-7626
RPL6	-7578
EIF3M	-7487
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
EIF3E	-6765
RPL26L1	-6585
EIF3C	-5490
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF2S2	-4156
RPL39L	-3915
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF4E	2570
RPL9	3863
EIF4A2	4080
RPS26	9966

---

Formation of annular gap junctions

set	Formation of annular gap junctions
setSize	10
pANOVA	4.28e-05
s.dist	-0.747
p.adjustANOVA	0.000257

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTA	-10572
AP2M1	-10048
ACTG1	-9853
DNM2	-9815
CLTB	-9239
CLTCL1	-8385
DAB2	-7871
ACTB	-7107
CLTC	-4506
DNM1	-2696

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTA	-10572
AP2M1	-10048
ACTG1	-9853
DNM2	-9815
CLTB	-9239
CLTCL1	-8385
DAB2	-7871
ACTB	-7107
CLTC	-4506
DNM1	-2696

---

GTP hydrolysis and joining of the 60S ribosomal subunit

set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	110
pANOVA	8.08e-41
s.dist	-0.737
p.adjustANOVA	8.65e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
RPL14	-8455
EIF3B	-8402
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
EIF3H	-7626
RPL6	-7578
EIF3M	-7487
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
EIF3E	-6765
RPL26L1	-6585
EIF3C	-5490
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF5	-4985
EIF2S2	-4156
RPL39L	-3915
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF4E	2570
RPL9	3863
EIF4A2	4080
EIF5B	4271
RPS26	9966

---

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

set	Beta oxidation of hexanoyl-CoA to butanoyl-CoA
setSize	5
pANOVA	0.00484
s.dist	-0.728
p.adjustANOVA	0.0164

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HADHA	-10505
HADHB	-9580
ACADS	-8406
ECHS1	-8253
HADH	-2245

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HADHA	-10505
HADHB	-9580
ACADS	-8406
ECHS1	-8253
HADH	-2245

---

Phosphate bond hydrolysis by NUDT proteins

set	Phosphate bond hydrolysis by NUDT proteins
setSize	7
pANOVA	0.000924
s.dist	-0.723
p.adjustANOVA	0.00408

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUDT16	-10678
NUDT1	-9686
NUDT9	-7274
NUDT18	-6825
NUDT5	-6736
NUDT15	-6669
ADPRM	-6358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUDT16	-10678
NUDT1	-9686
NUDT9	-7274
NUDT18	-6825
NUDT5	-6736
NUDT15	-6669
ADPRM	-6358

---

Cap-dependent Translation Initiation

set	Cap-dependent Translation Initiation
setSize	117
pANOVA	1.23e-41
s.dist	-0.722
p.adjustANOVA	1.39e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
PABPC1	-9847
EIF4EBP1	-9839
RPL36	-9835
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
RPL14	-8455
EIF3B	-8402
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
EIF3H	-7626
RPL6	-7578
EIF3M	-7487
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
EIF2B3	-6949
RPL22	-6932
EIF3E	-6765
RPL26L1	-6585
EIF3C	-5490
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF5	-4985
EIF2B1	-4807
EIF2S2	-4156
RPL39L	-3915
EIF2B4	-3645
EIF2B2	-2627
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF2B5	1904
EIF4E	2570
RPL9	3863
EIF4A2	4080
EIF5B	4271
RPS26	9966

---

Eukaryotic Translation Initiation

set	Eukaryotic Translation Initiation
setSize	117
pANOVA	1.23e-41
s.dist	-0.722
p.adjustANOVA	1.39e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
PABPC1	-9847
EIF4EBP1	-9839
RPL36	-9835
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
RPL14	-8455
EIF3B	-8402
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
EIF3H	-7626
RPL6	-7578
EIF3M	-7487
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
EIF2B3	-6949
RPL22	-6932
EIF3E	-6765
RPL26L1	-6585
EIF3C	-5490
EIF4A1	-5296
RPL36A	-5184
RPSA	-5038
EIF5	-4985
EIF2B1	-4807
EIF2S2	-4156
RPL39L	-3915
EIF2B4	-3645
EIF2B2	-2627
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF2B5	1904
EIF4E	2570
RPL9	3863
EIF4A2	4080
EIF5B	4271
RPS26	9966

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	99
pANOVA	1.99e-35
s.dist	-0.721
p.adjustANOVA	1.28e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
TRIB3	-9890
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
EIF2AK4	-9460
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
ATF4	-7609
RPL6	-7578
RPL23A	-7352
RPS3A	-7225
RPS5	-7123
RPL22	-6932
RPL26L1	-6585
CEBPG	-5771
RPL36A	-5184
RPSA	-5038
GCN1	-4661
EIF2S2	-4156
RPL39L	-3915
IMPACT	-2268
CEBPB	-1721
EIF2S3	210
RPS27L	697
EIF2S1	788
ATF2	3658
RPL9	3863
ATF3	4005
DDIT3	4466
ASNS	9538
RPS26	9966

---

Formation of the ternary complex, and subsequently, the 43S complex

set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	4.3e-18
s.dist	-0.701
p.adjustANOVA	1.36e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
RPS25	-9805
EIF3F	-9801
RPS15A	-9793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPS3	-9754
EIF3L	-9713
RPS18	-9326
EIF3D	-9263
RPS2	-9203
RPS20	-9133
RPS6	-9022
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
EIF3B	-8402
RPS24	-8227
RPS4Y1	-8159
RPS14	-7756
EIF3H	-7626
EIF3M	-7487
RPS3A	-7225
RPS5	-7123
EIF3E	-6765
EIF3C	-5490
RPSA	-5038
EIF2S2	-4156
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
RPS26	9966

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	59
pANOVA	1.07e-19
s.dist	-0.683
p.adjustANOVA	3.98e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
PABPC1	-9847
EIF4EBP1	-9839

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
PABPC1	-9847
EIF4EBP1	-9839
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPS2	-9203
RPS20	-9133
RPS6	-9022
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
EIF3B	-8402
RPS24	-8227
RPS4Y1	-8159
RPS14	-7756
EIF3H	-7626
EIF3M	-7487
RPS3A	-7225
RPS5	-7123
EIF3E	-6765
EIF3C	-5490
EIF4A1	-5296
RPSA	-5038
EIF2S2	-4156
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF4E	2570
EIF4A2	4080
RPS26	9966

---

Translation initiation complex formation

set	Translation initiation complex formation
setSize	58
pANOVA	3.54e-19
s.dist	-0.679
p.adjustANOVA	1.22e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
PABPC1	-9847
RPS25	-9805

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
PABPC1	-9847
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPS2	-9203
RPS20	-9133
RPS6	-9022
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
EIF3B	-8402
RPS24	-8227
RPS4Y1	-8159
RPS14	-7756
EIF3H	-7626
EIF3M	-7487
RPS3A	-7225
RPS5	-7123
EIF3E	-6765
EIF3C	-5490
EIF4A1	-5296
RPSA	-5038
EIF2S2	-4156
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF4E	2570
EIF4A2	4080
RPS26	9966

---

Ribosomal scanning and start codon recognition

set	Ribosomal scanning and start codon recognition
setSize	58
pANOVA	8.85e-19
s.dist	-0.671
p.adjustANOVA	2.94e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4H	-10672
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
RPS25	-9805
EIF3F	-9801

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4H	-10672
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
EIF3K	-10049
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
EIF3I	-9929
RPS19	-9917
RPS10	-9910
RPS25	-9805
EIF3F	-9801
RPS15A	-9793
RPS3	-9754
EIF3L	-9713
EIF4B	-9690
RPS18	-9326
EIF4G1	-9300
EIF3D	-9263
RPS2	-9203
RPS20	-9133
RPS6	-9022
RPS12	-8859
RPS8	-8798
RPS27A	-8754
EIF3G	-8639
RPS17	-8543
EIF3B	-8402
RPS24	-8227
RPS4Y1	-8159
RPS14	-7756
EIF3H	-7626
EIF3M	-7487
RPS3A	-7225
RPS5	-7123
EIF3E	-6765
EIF3C	-5490
EIF4A1	-5296
RPSA	-5038
EIF5	-4985
EIF2S2	-4156
EIF3A	-1312
EIF2S3	210
EIF3J	294
EIF1AX	539
RPS27L	697
EIF2S1	788
EIF4E	2570
EIF4A2	4080
RPS26	9966

---

SUMO is conjugated to E1 (UBA2:SAE1)

set	SUMO is conjugated to E1 (UBA2:SAE1)
setSize	5
pANOVA	0.0096
s.dist	-0.669
p.adjustANOVA	0.0286

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SUMO3	-10588
SAE1	-10344
SUMO2	-5820
UBA2	-5114
SUMO1	-3911

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SUMO3	-10588
SAE1	-10344
SUMO2	-5820
UBA2	-5114
SUMO1	-3911

---

Fructose metabolism

set	Fructose metabolism
setSize	7
pANOVA	0.00223
s.dist	-0.667
p.adjustANOVA	0.00879

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1B1	-10445
KHK	-9236
SORD	-9159
TKFC	-9039
ALDH1A1	-7011
GLYCTK	-6816
ALDOB	1729

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1B1	-10445
KHK	-9236
SORD	-9159
TKFC	-9039
ALDH1A1	-7011
GLYCTK	-6816
ALDOB	1729

---

Selenoamino acid metabolism

set	Selenoamino acid metabolism
setSize	114
pANOVA	9.64e-35
s.dist	-0.665
p.adjustANOVA	5.99e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
QARS1	-10539
AHCY	-10530
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
QARS1	-10539
AHCY	-10530
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
EEFSEC	-9700
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
PAPSS1	-8637
RPS17	-8543
RPL14	-8455
RPL18	-8393
TXNRD1	-8388
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
SARS1	-7477
RPL23A	-7352
GNMT	-7237
RPS3A	-7225
RPS5	-7123
KARS1	-7027
RPL22	-6932
RPL26L1	-6585
CBS	-6565
SEPHS2	-6489
GSR	-6423
AIMP2	-6319
EPRS1	-5278
RPL36A	-5184
RPSA	-5038
EEF1E1	-5012
RPL39L	-3915
MARS1	-3868
DARS1	-2632
PAPSS2	-2073
HNMT	-1897
NNMT	-953
AIMP1	602
RPS27L	697
RARS1	1302
RPL9	3863
SEPSECS	4289
IARS1	4495
SCLY	4593
LARS1	4746
SECISBP2	4932
INMT	5280
PSTK	7423
RPS26	9966
CTH	10820

---

Prevention of phagosomal-lysosomal fusion

set	Prevention of phagosomal-lysosomal fusion
setSize	9
pANOVA	0.000589
s.dist	-0.661
p.adjustANOVA	0.00278

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10332
RAB7A	-9632
CORO1A	-9090
RPS27A	-8754
UBC	-8748
VPS33B	-8152
UBB	-6271
HGS	-4170
RAB5A	1484

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10332
RAB7A	-9632
CORO1A	-9090
RPS27A	-8754
UBC	-8748
VPS33B	-8152
UBB	-6271
HGS	-4170
RAB5A	1484

---

VLDLR internalisation and degradation

set	VLDLR internalisation and degradation
setSize	15
pANOVA	9.51e-06
s.dist	-0.66
p.adjustANOVA	6.3e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CLTA	-10572
UBA52	-10332
AP2M1	-10048
AP2S1	-8994
RPS27A	-8754
UBC	-8748
NR1H2	-8529
NR1H3	-7970
MYLIP	-7310
AP2A1	-6893
UBB	-6271
AP2B1	-5409
AP2A2	-5314
CLTC	-4506
VLDLR	3782

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CLTA	-10572
UBA52	-10332
AP2M1	-10048
AP2S1	-8994
RPS27A	-8754
UBC	-8748
NR1H2	-8529
NR1H3	-7970
MYLIP	-7310
AP2A1	-6893
UBB	-6271
AP2B1	-5409
AP2A2	-5314
CLTC	-4506
VLDLR	3782

---

Nef Mediated CD4 Down-regulation

set	Nef Mediated CD4 Down-regulation
setSize	9
pANOVA	0.000676
s.dist	-0.654
p.adjustANOVA	0.00316

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARF1	-10398
AP2M1	-10048
AP2S1	-8994
LCK	-6909
AP2A1	-6893
AP2B1	-5409
AP2A2	-5314
ATP6V1H	-4897
CD4	-4088

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARF1	-10398
AP2M1	-10048
AP2S1	-8994
LCK	-6909
AP2A1	-6893
AP2B1	-5409
AP2A2	-5314
ATP6V1H	-4897
CD4	-4088

---

Abacavir ADME

set	Abacavir ADME
setSize	5
pANOVA	0.0116
s.dist	0.652
p.adjustANOVA	0.0334

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ABCB1	10090
SLC22A1	10005
ABCG2	6197
ADAL	5768
NT5C2	4351

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ABCB1	10090
SLC22A1	10005
ABCG2	6197
ADAL	5768
NT5C2	4351

---

NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose

set	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
setSize	5
pANOVA	0.0121
s.dist	-0.648
p.adjustANOVA	0.0343

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NR1H2	-8529
NR1H3	-7970
PLIN1	-7420
RXRA	-6249
RXRB	-4475

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NR1H2	-8529
NR1H3	-7970
PLIN1	-7420
RXRA	-6249
RXRB	-4475

---

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

set	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
setSize	9
pANOVA	0.000777
s.dist	-0.647
p.adjustANOVA	0.00352

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10332
AKT1	-10307
RPS27A	-8754
UBC	-8748
ARAP1	-7851
UBB	-6271
PTK6	-4827
DOK1	-4531
CBL	-606

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10332
AKT1	-10307
RPS27A	-8754
UBC	-8748
ARAP1	-7851
UBB	-6271
PTK6	-4827
DOK1	-4531
CBL	-606

---

Regulation of expression of SLITs and ROBOs

set	Regulation of expression of SLITs and ROBOs
setSize	148
pANOVA	3.67e-42
s.dist	-0.647
p.adjustANOVA	5.44e-40

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
PSMB7	-10249
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
PSMC4	-10117

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
PSMB7	-10249
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
PSMC4	-10117
RPS11	-10105
RPS15	-10068
PSMA7	-10066
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
PSMD8	-9935
PSMB6	-9918
RPS19	-9917
RPL12	-9913
RPS10	-9910
PSMC5	-9900
RPL8	-9851
PABPC1	-9847
RPL36	-9835
PSMA6	-9834
RPS25	-9805
PSMB5	-9803
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
PSMD13	-9668
RPL13	-9613
RPL17	-9603
RBX1	-9547
RPL24	-9546
PSMC3	-9417
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
ELOB	-9312
EIF4G1	-9300
RPL11	-9252
RPL36AL	-9238
PSMB1	-9205
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
ADRM1	-8795
RPS27A	-8754
UBC	-8748
ELOC	-8711
PSMA1	-8638
PSMB3	-8560
RPS17	-8543
PSMD3	-8533
RPL14	-8455
RPL18	-8393
PSMD14	-8341
PSMC1	-8337
PSMA2	-8270
RPS24	-8227
RPS4Y1	-8159
PSMB4	-8140
RPL26	-8119
PSMB2	-7917
PSMA5	-7902
RPL21	-7867
RPLP2	-7849
PSMD2	-7819
RPS14	-7756
RPL6	-7578
RPL23A	-7352
DAG1	-7338
RBM8A	-7298
RPS3A	-7225
RPS5	-7123
SEM1	-7005
ZSWIM8	-6942
RPL22	-6932
MAGOH	-6720
RNPS1	-6673
RPL26L1	-6585
ROBO1	-6398
PSMC2	-6390
UBB	-6271
PSMD7	-6230
EIF4A3	-6214
ETF1	-5979
LDB1	-5760
RPL36A	-5184
RPSA	-5038
PSMD1	-5001
PSMA4	-3986
RPL39L	-3915
CASC3	-3707
SLIT1	-3396
NCBP2	-837
RPS27L	697
LHX4	711
GSPT2	883
ROBO3	1470
MAGOHB	2453
PSMC6	3250
USP33	3631
RPL9	3863
GSPT1	3980
PSMD6	4161
PSMD11	4230
PSMD12	4365
UPF3A	5913
NCBP1	6089
COL4A5	6244
PSMA3	6771
UPF3B	8141
UPF2	8369
CUL2	8949
RPS26	9966

---

NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake

set	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
setSize	5
pANOVA	0.0124
s.dist	-0.646
p.adjustANOVA	0.0349

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NR1H2	-8529
NR1H3	-7970
MYLIP	-7310
RXRA	-6249
RXRB	-4475

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NR1H2	-8529
NR1H3	-7970
MYLIP	-7310
RXRA	-6249
RXRB	-4475

---

Formation of xylulose-5-phosphate

set	Formation of xylulose-5-phosphate
setSize	5
pANOVA	0.0127
s.dist	-0.643
p.adjustANOVA	0.0359

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CRYL1	-9878
SORD	-9159
DCXR	-9134
AKR1A1	-8226
XYLB	2014

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CRYL1	-9878
SORD	-9159
DCXR	-9134
AKR1A1	-8226
XYLB	2014

---

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

set	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
setSize	5
pANOVA	0.0138
s.dist	-0.636
p.adjustANOVA	0.0381

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HADHA	-10505
HADHB	-9580
ECHS1	-8253
ACADL	-3410
HADH	-2245

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HADHA	-10505
HADHB	-9580
ECHS1	-8253
ACADL	-3410
HADH	-2245

---

FLT3 signaling by CBL mutants

set	FLT3 signaling by CBL mutants
setSize	7
pANOVA	0.00356
s.dist	-0.636
p.adjustANOVA	0.0128

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FLT3	-10768
UBA52	-10332
RPS27A	-8754
UBC	-8748
UBB	-6271
FLT3LG	-2104
CBL	-606

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FLT3	-10768
UBA52	-10332
RPS27A	-8754
UBC	-8748
UBB	-6271
FLT3LG	-2104
CBL	-606

---

Pentose phosphate pathway

set	Pentose phosphate pathway
setSize	13
pANOVA	7.55e-05
s.dist	-0.634
p.adjustANOVA	0.000436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPIA	-10202
SHPK	-9892
PGD	-9624
PGLS	-9094
PRPS1	-8784
TKT	-8606
TALDO1	-8526
G6PD	-8445
PGM2	-5864
PRPS2	-4009
DERA	-2879
RPE	-2601
RBKS	497

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPIA	-10202
SHPK	-9892
PGD	-9624
PGLS	-9094
PRPS1	-8784
TKT	-8606
TALDO1	-8526
G6PD	-8445
PGM2	-5864
PRPS2	-4009
DERA	-2879
RPE	-2601
RBKS	497

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	113
pANOVA	1.22e-30
s.dist	-0.626
p.adjustANOVA	6.05e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
PABPC1	-9847
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
PPP2R1A	-8938
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RBM8A	-7298
RPS3A	-7225
RPS5	-7123
RPL22	-6932
MAGOH	-6720
RNPS1	-6673
UPF1	-6634
RPL26L1	-6585
EIF4A3	-6214
ETF1	-5979
PPP2CA	-5632
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
CASC3	-3707
SMG5	-3036
NCBP2	-837
SMG8	314
SMG6	520
RPS27L	697
GSPT2	883
PNRC2	1095
SMG9	1865
MAGOHB	2453
DCP1A	2795
RPL9	3863
GSPT1	3980
UPF3A	5913
NCBP1	6089
SMG1	6578
UPF3B	8141
UPF2	8369
PPP2R2A	8795
RPS26	9966
SMG7	10441

---

Nonsense-Mediated Decay (NMD)

set	Nonsense-Mediated Decay (NMD)
setSize	113
pANOVA	1.22e-30
s.dist	-0.626
p.adjustANOVA	6.05e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
RPL8	-9851
PABPC1	-9847
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
EIF4G1	-9300
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
PPP2R1A	-8938
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
RPL21	-7867
RPLP2	-7849
RPS14	-7756
RPL6	-7578
RPL23A	-7352
RBM8A	-7298
RPS3A	-7225
RPS5	-7123
RPL22	-6932
MAGOH	-6720
RNPS1	-6673
UPF1	-6634
RPL26L1	-6585
EIF4A3	-6214
ETF1	-5979
PPP2CA	-5632
RPL36A	-5184
RPSA	-5038
RPL39L	-3915
CASC3	-3707
SMG5	-3036
NCBP2	-837
SMG8	314
SMG6	520
RPS27L	697
GSPT2	883
PNRC2	1095
SMG9	1865
MAGOHB	2453
DCP1A	2795
RPL9	3863
GSPT1	3980
UPF3A	5913
NCBP1	6089
SMG1	6578
UPF3B	8141
UPF2	8369
PPP2R2A	8795
RPS26	9966
SMG7	10441

---

Protein repair

set	Protein repair
setSize	6
pANOVA	0.00798
s.dist	-0.625
p.adjustANOVA	0.025

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TXN	-9467
PCMT1	-9080
MSRB2	-7808
MSRB1	-7737
MSRA	-7677
MSRB3	1687

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TXN	-9467
PCMT1	-9080
MSRB2	-7808
MSRB1	-7737
MSRA	-7677
MSRB3	1687

---

Ethanol oxidation

set	Ethanol oxidation
setSize	7
pANOVA	0.00423
s.dist	-0.624
p.adjustANOVA	0.0148

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ALDH1B1	-10134
ADH5	-10088
ACSS1	-8465
ALDH2	-7438
ALDH1A1	-7011
ACSS2	-3276
ADH1B	-260

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ALDH1B1	-10134
ADH5	-10088
ACSS1	-8465
ALDH2	-7438
ALDH1A1	-7011
ACSS2	-3276
ADH1B	-260

---

Defective CFTR causes cystic fibrosis

set	Defective CFTR causes cystic fibrosis
setSize	47
pANOVA	1.75e-13
s.dist	-0.621
p.adjustANOVA	3.79e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10332
PSMB7	-10249
PSMC4	-10117
PSMA7	-10066
VCP	-10053
PSMD8	-9935
PSMB6	-9918
PSMC5	-9900
PSMA6	-9834
PSMB5	-9803
PSMD13	-9668
PSMC3	-9417
PSMB1	-9205
RNF185	-9095
OS9	-9026
ADRM1	-8795
RPS27A	-8754
UBC	-8748
PSMA1	-8638
PSMB3	-8560

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10332
PSMB7	-10249
PSMC4	-10117
PSMA7	-10066
VCP	-10053
PSMD8	-9935
PSMB6	-9918
PSMC5	-9900
PSMA6	-9834
PSMB5	-9803
PSMD13	-9668
PSMC3	-9417
PSMB1	-9205
RNF185	-9095
OS9	-9026
ADRM1	-8795
RPS27A	-8754
UBC	-8748
PSMA1	-8638
PSMB3	-8560
PSMD3	-8533
RNF5	-8487
PSMD14	-8341
PSMC1	-8337
PSMA2	-8270
PSMB4	-8140
PSMB2	-7917
PSMA5	-7902
PSMD2	-7819
DERL2	-7770
ERLIN2	-7173
SEM1	-7005
PSMC2	-6390
UBB	-6271
PSMD7	-6230
ERLIN1	-5833
ERLEC1	-5657
DERL3	-5542
PSMD1	-5001
PSMA4	-3986
DERL1	-1584
SEL1L	-1445
PSMC6	3250
PSMD6	4161
PSMD11	4230
PSMD12	4365
PSMA3	6771

---

Formyl peptide receptors bind formyl peptides and many other ligands

set	Formyl peptide receptors bind formyl peptides and many other ligands
setSize	7
pANOVA	0.00458
s.dist	-0.619
p.adjustANOVA	0.0157

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APP	-10604
ANXA1	-10292
MT-RNR2	-8799
HEBP1	-8775
FPR3	-8707
FPR1	-5019
FPR2	5948

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APP	-10604
ANXA1	-10292
MT-RNR2	-8799
HEBP1	-8775
FPR3	-8707
FPR1	-5019
FPR2	5948

---

Josephin domain DUBs

set	Josephin domain DUBs
setSize	10
pANOVA	0.000711
s.dist	-0.618
p.adjustANOVA	0.00328

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-10332
VCP	-10053
RAD23A	-9332
RPS27A	-8754
UBC	-8748
JOSD2	-7517
RAD23B	-6552
UBB	-6271
JOSD1	-6070
ATXN3	7626

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-10332
VCP	-10053
RAD23A	-9332
RPS27A	-8754
UBC	-8748
JOSD2	-7517
RAD23B	-6552
UBB	-6271
JOSD1	-6070
ATXN3	7626

---

Cellular response to starvation

set	Cellular response to starvation
setSize	147
pANOVA	1.11e-37
s.dist	-0.612
p.adjustANOVA	8.55e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL37A	-10648
RPS7	-10523
RPL39	-10493
RPL35A	-10475
RPL30	-10461
RPL37	-10428
RPL38	-10407
RPL31	-10367
RPL41	-10334
UBA52	-10332
RPL23	-10306
RPL15	-10283
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPL34	-10201
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPL27	-10037
RPS27	-10010
RPS9	-10004
RPL32	-10001
RPS23	-9991
RPL10A	-9986
SEC13	-9968
ATP6V0B	-9964
RPS21	-9962
LAMTOR4	-9955
RPS28	-9946
RPS19	-9917
RPL12	-9913
RPS10	-9910
TRIB3	-9890
ATP6V1F	-9869
RPL8	-9851
RPL36	-9835
RPS25	-9805
RPS15A	-9793
RPL35	-9790
RPS3	-9754
RPL7	-9677
RPL13	-9613
RPL17	-9603
RPL24	-9546
EIF2AK4	-9460
RPLP0	-9380
RPL10	-9365
RPL5	-9360
RPL28	-9339
RPS18	-9326
ATP6V1E2	-9286
RPL11	-9252
RPL36AL	-9238
RPS2	-9203
ATP6V0E1	-9160
RPLP1	-9141
RPS20	-9133
RPL19	-9122
RPL3	-9098
RPL7A	-9087
RPL27A	-9068
RPL4	-9066
RPL13A	-9051
RPS6	-9022
RPL29	-9015
RPL22L1	-8967
RPL18A	-8962
RPS12	-8859
RPS8	-8798
RPS27A	-8754
LAMTOR1	-8716
LAMTOR2	-8686
MIOS	-8567
RPS17	-8543
RPL14	-8455
RPL18	-8393
RPS24	-8227
RPS4Y1	-8159
RPL26	-8119
TCIRG1	-7952
RPL21	-7867
RPLP2	-7849
KPTN	-7837
RPS14	-7756
ATP6V0C	-7720
ATF4	-7609
RPL6	-7578
RPTOR	-7419
RPL23A	-7352
MLST8	-7309
RPS3A	-7225
FNIP2	-7170
ATP6V1G1	-7149
RPS5	-7123
RRAGA	-7121
RPL22	-6932
LAMTOR5	-6808
RPL26L1	-6585
ATP6V1B2	-6324
RHEB	-6171
CEBPG	-5771
SESN2	-5586
WDR59	-5449
RPL36A	-5184
RRAGD	-5133
ATP6V1E1	-5080
RPSA	-5038
WDR24	-5034
ATP6V1H	-4897
ATP6V0E2	-4838
GCN1	-4661
MTOR	-4637
EIF2S2	-4156
ITFG2	-3987
ATP6V1A	-3962
RPL39L	-3915
NPRL2	-3419
BMT2	-3054
IMPACT	-2268
ATP6V1G2	-2193
RRAGB	-2080
CEBPB	-1721
ATP6V1C1	-1701
RRAGC	-1549
SH3BP4	-1512
EIF2S3	210
NPRL3	217
SEH1L	247
SESN1	383
SZT2	518
RPS27L	697
ATP6V1D	760
EIF2S1	788
LAMTOR3	940
ATF2	3658
RPL9	3863
ATF3	4005
DDIT3	4466
SLC38A9	4639
DEPDC5	4711
FNIP1	6168
FLCN	6466
ASNS	9538
ATP6V1C2	9916
RPS26	9966

---

SARS-CoV-2 modulates host translation machinery

set	SARS-CoV-2 modulates host translation machinery
setSize	49
pANOVA	1.44e-13
s.dist	-0.61
p.adjustANOVA	3.15e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPS10	-9910
RPS25	-9805
RPS15A	-9793
RPS3	-9754
GEMIN4	-9676
SNRPD2	-9619

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS7	-10523
RPS16	-10241
RPS13	-10237
FAU	-10228
RPS29	-10207
RPS4X	-10162
RPS11	-10105
RPS15	-10068
RPS27	-10010
RPS9	-10004
RPS23	-9991
RPS21	-9962
RPS28	-9946
RPS19	-9917
RPS10	-9910
RPS25	-9805
RPS15A	-9793
RPS3	-9754
GEMIN4	-9676
SNRPD2	-9619
SNRPF	-9618
RPS18	-9326
RPS2	-9203
SNRPB	-9152
RPS20	-9133
RPS6	-9022
RPS12	-8859
RPS8	-8798
RPS27A	-8754
RPS17	-8543
RPS24	-8227
RPS4Y1	-8159
SNRPG	-8017
SNRPE	-7769
RPS14	-7756
RPS3A	-7225
RPS5	-7123
SNRPD3	-6833
RPSA	-5038
GEMIN7	-2549
SNRPD1	-1039
RPS27L	697
GEMIN8	2213
DDX20	3645
GEMIN6	4488
GEMIN2	5342
GEMIN5	6436
SMN1	9022
RPS26	9966

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report