date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.6891322
A1BG 0.2163555
A1BG-AS1 -0.4425330
A1CF -0.5935004
A2M 1.2986453
A2M-AS1 0.4479278

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21870
duplicated_genes_present 0
num_profile_genes_in_sets 8802
num_profile_genes_not_in_sets 13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1189
num_genesets_included 1536

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Phosphate bond hydrolysis by NTPDase proteins 5 5.96e-03 -0.710 0.042800
SUMO is conjugated to E1 (UBA2:SAE1) 5 9.18e-03 -0.673 0.058000
SUMO is proteolytically processed 6 5.89e-03 -0.649 0.042500
Wax and plasmalogen biosynthesis 5 1.37e-02 -0.637 0.076700
Branched-chain ketoacid dehydrogenase kinase deficiency 5 1.38e-02 -0.636 0.076900
Calcitonin-like ligand receptors 5 1.61e-02 0.621 0.084300
Activation of caspases through apoptosome-mediated cleavage 6 1.08e-02 -0.601 0.064500
Phosphate bond hydrolysis by NUDT proteins 7 6.58e-03 -0.593 0.046300
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.27e-03 -0.588 0.014500
Regulation of NFE2L2 gene expression 8 4.28e-03 0.583 0.034300
PDH complex synthesizes acetyl-CoA from PYR 5 2.59e-02 -0.575 0.111000
Estrogen-stimulated signaling through PRKCZ 6 1.54e-02 -0.571 0.082500
Formation of xylulose-5-phosphate 5 2.76e-02 -0.569 0.115000
Small interfering RNA (siRNA) biogenesis 9 3.38e-03 -0.564 0.029000
Abacavir ADME 5 2.95e-02 0.562 0.120000
H139Hfs13* PPM1K causes a mild variant of MSUD 5 2.95e-02 -0.562 0.120000
Maple Syrup Urine Disease 5 2.95e-02 -0.562 0.120000
Erythropoietin activates STAT5 6 2.02e-02 -0.547 0.096900
Beta-oxidation of pristanoyl-CoA 9 4.50e-03 -0.547 0.035300
Cytochrome c-mediated apoptotic response 13 6.67e-04 -0.545 0.008880
Processing and activation of SUMO 10 3.66e-03 -0.531 0.030400
Erythrocytes take up oxygen and release carbon dioxide 7 1.74e-02 0.519 0.087500
Protein repair 6 2.82e-02 -0.517 0.117000
ATF6 (ATF6-alpha) activates chaperones 12 2.06e-03 -0.514 0.020300
Apoptosis induced DNA fragmentation 10 5.77e-03 -0.504 0.042000
Miscellaneous substrates 8 1.45e-02 0.499 0.079100
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 2.25e-02 -0.498 0.103000
Formyl peptide receptors bind formyl peptides and many other ligands 7 2.34e-02 -0.495 0.105000
Noncanonical activation of NOTCH3 8 1.61e-02 -0.492 0.084300
Formation of apoptosome 11 4.76e-03 -0.491 0.036400
Regulation of the apoptosome activity 11 4.76e-03 -0.491 0.036400
CYP2E1 reactions 5 5.78e-02 0.490 0.186000
MAPK3 (ERK1) activation 10 7.32e-03 -0.490 0.049700
Defects of platelet adhesion to exposed collagen 7 2.53e-02 0.488 0.110000
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 5.91e-02 -0.487 0.188000
Apoptotic cleavage of cell adhesion proteins 8 1.75e-02 -0.485 0.087500
Advanced glycosylation endproduct receptor signaling 12 3.67e-03 -0.484 0.030400
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 8.09e-04 -0.484 0.010300
MASTL Facilitates Mitotic Progression 10 8.10e-03 -0.484 0.053600
Negative feedback regulation of MAPK pathway 6 4.25e-02 -0.478 0.154000
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 4.30e-02 -0.477 0.155000
TGFBR3 PTM regulation 10 9.46e-03 -0.474 0.059000
PTK6 promotes HIF1A stabilization 6 4.56e-02 -0.471 0.162000
ER Quality Control Compartment (ERQC) 21 1.92e-04 -0.470 0.003400
ATF6 (ATF6-alpha) activates chaperone genes 10 1.01e-02 -0.470 0.061200
Cellular response to mitochondrial stress 9 1.55e-02 -0.466 0.082500
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 1.04e-05 -0.465 0.000364
Diseases of branched-chain amino acid catabolism 13 3.93e-03 -0.462 0.031800
Gain-of-function MRAS complexes activate RAF signaling 8 2.41e-02 -0.461 0.107000
SHOC2 M1731 mutant abolishes MRAS complex function 8 2.41e-02 -0.461 0.107000


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Phosphate bond hydrolysis by NTPDase proteins 5 5.96e-03 -7.10e-01 4.28e-02
SUMO is conjugated to E1 (UBA2:SAE1) 5 9.18e-03 -6.73e-01 5.80e-02
SUMO is proteolytically processed 6 5.89e-03 -6.49e-01 4.25e-02
Wax and plasmalogen biosynthesis 5 1.37e-02 -6.37e-01 7.67e-02
Branched-chain ketoacid dehydrogenase kinase deficiency 5 1.38e-02 -6.36e-01 7.69e-02
Calcitonin-like ligand receptors 5 1.61e-02 6.21e-01 8.43e-02
Activation of caspases through apoptosome-mediated cleavage 6 1.08e-02 -6.01e-01 6.45e-02
Phosphate bond hydrolysis by NUDT proteins 7 6.58e-03 -5.93e-01 4.63e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.27e-03 -5.88e-01 1.45e-02
Regulation of NFE2L2 gene expression 8 4.28e-03 5.83e-01 3.43e-02
PDH complex synthesizes acetyl-CoA from PYR 5 2.59e-02 -5.75e-01 1.11e-01
Estrogen-stimulated signaling through PRKCZ 6 1.54e-02 -5.71e-01 8.25e-02
Formation of xylulose-5-phosphate 5 2.76e-02 -5.69e-01 1.15e-01
Small interfering RNA (siRNA) biogenesis 9 3.38e-03 -5.64e-01 2.90e-02
Abacavir ADME 5 2.95e-02 5.62e-01 1.20e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 2.95e-02 -5.62e-01 1.20e-01
Maple Syrup Urine Disease 5 2.95e-02 -5.62e-01 1.20e-01
Erythropoietin activates STAT5 6 2.02e-02 -5.47e-01 9.69e-02
Beta-oxidation of pristanoyl-CoA 9 4.50e-03 -5.47e-01 3.53e-02
Cytochrome c-mediated apoptotic response 13 6.67e-04 -5.45e-01 8.88e-03
Processing and activation of SUMO 10 3.66e-03 -5.31e-01 3.04e-02
Erythrocytes take up oxygen and release carbon dioxide 7 1.74e-02 5.19e-01 8.75e-02
Protein repair 6 2.82e-02 -5.17e-01 1.17e-01
ATF6 (ATF6-alpha) activates chaperones 12 2.06e-03 -5.14e-01 2.03e-02
Apoptosis induced DNA fragmentation 10 5.77e-03 -5.04e-01 4.20e-02
Miscellaneous substrates 8 1.45e-02 4.99e-01 7.91e-02
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 2.25e-02 -4.98e-01 1.03e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 2.34e-02 -4.95e-01 1.05e-01
Noncanonical activation of NOTCH3 8 1.61e-02 -4.92e-01 8.43e-02
Formation of apoptosome 11 4.76e-03 -4.91e-01 3.64e-02
Regulation of the apoptosome activity 11 4.76e-03 -4.91e-01 3.64e-02
CYP2E1 reactions 5 5.78e-02 4.90e-01 1.86e-01
MAPK3 (ERK1) activation 10 7.32e-03 -4.90e-01 4.97e-02
Defects of platelet adhesion to exposed collagen 7 2.53e-02 4.88e-01 1.10e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 5.91e-02 -4.87e-01 1.88e-01
Apoptotic cleavage of cell adhesion proteins 8 1.75e-02 -4.85e-01 8.75e-02
Advanced glycosylation endproduct receptor signaling 12 3.67e-03 -4.84e-01 3.04e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 8.09e-04 -4.84e-01 1.03e-02
MASTL Facilitates Mitotic Progression 10 8.10e-03 -4.84e-01 5.36e-02
Negative feedback regulation of MAPK pathway 6 4.25e-02 -4.78e-01 1.54e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 4.30e-02 -4.77e-01 1.55e-01
TGFBR3 PTM regulation 10 9.46e-03 -4.74e-01 5.90e-02
PTK6 promotes HIF1A stabilization 6 4.56e-02 -4.71e-01 1.62e-01
ER Quality Control Compartment (ERQC) 21 1.92e-04 -4.70e-01 3.40e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 1.01e-02 -4.70e-01 6.12e-02
Cellular response to mitochondrial stress 9 1.55e-02 -4.66e-01 8.25e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 1.04e-05 -4.65e-01 3.64e-04
Diseases of branched-chain amino acid catabolism 13 3.93e-03 -4.62e-01 3.18e-02
Gain-of-function MRAS complexes activate RAF signaling 8 2.41e-02 -4.61e-01 1.07e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 2.41e-02 -4.61e-01 1.07e-01
Signaling by MRAS-complex mutants 8 2.41e-02 -4.61e-01 1.07e-01
MAPK1 (ERK2) activation 9 1.68e-02 -4.60e-01 8.51e-02
SMAC (DIABLO) binds to IAPs 7 3.55e-02 -4.59e-01 1.35e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 3.55e-02 -4.59e-01 1.35e-01
SMAC, XIAP-regulated apoptotic response 7 3.55e-02 -4.59e-01 1.35e-01
Synthesis of pyrophosphates in the cytosol 8 2.56e-02 -4.56e-01 1.10e-01
ARMS-mediated activation 6 5.35e-02 -4.55e-01 1.78e-01
NRIF signals cell death from the nucleus 15 2.38e-03 -4.53e-01 2.26e-02
MET activates PI3K/AKT signaling 5 8.03e-02 -4.52e-01 2.31e-01
Calnexin/calreticulin cycle 26 6.95e-05 -4.51e-01 1.54e-03
Defective binding of VWF variant to GPIb:IX:V 6 5.61e-02 4.50e-01 1.82e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 6 5.61e-02 4.50e-01 1.82e-01
Cohesin Loading onto Chromatin 10 1.38e-02 -4.50e-01 7.69e-02
Transport of nucleotide sugars 9 2.05e-02 -4.46e-01 9.78e-02
Diseases of Base Excision Repair 5 8.44e-02 4.46e-01 2.39e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 5.23e-06 -4.45e-01 2.19e-04
Dermatan sulfate biosynthesis 6 6.04e-02 -4.43e-01 1.91e-01
SLC15A4:TASL-dependent IRF5 activation 6 6.06e-02 -4.42e-01 1.91e-01
Incretin synthesis, secretion, and inactivation 14 4.59e-03 -4.38e-01 3.55e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 4.59e-03 -4.38e-01 3.55e-02
Modulation by Mtb of host immune system 7 4.55e-02 -4.37e-01 1.62e-01
MET activates RAP1 and RAC1 10 1.69e-02 -4.36e-01 8.52e-02
Cation-coupled Chloride cotransporters 6 6.42e-02 4.36e-01 2.00e-01
NADE modulates death signalling 5 9.24e-02 -4.35e-01 2.55e-01
Formation of the active cofactor, UDP-glucuronate 5 9.53e-02 -4.31e-01 2.59e-01
IFNG signaling activates MAPKs 8 3.51e-02 -4.30e-01 1.35e-01
Platelet sensitization by LDL 16 2.96e-03 -4.29e-01 2.65e-02
CREB phosphorylation 7 5.13e-02 -4.25e-01 1.74e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 1.03e-01 4.20e-01 2.71e-01
IRAK4 deficiency (TLR2/4) 15 5.06e-03 -4.18e-01 3.81e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 1.06e-01 -4.18e-01 2.74e-01
Establishment of Sister Chromatid Cohesion 11 1.68e-02 -4.16e-01 8.51e-02
NFE2L2 regulating inflammation associated genes 5 1.08e-01 4.15e-01 2.79e-01
FGFR2b ligand binding and activation 6 7.88e-02 4.14e-01 2.28e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 3.15e-02 -4.14e-01 1.26e-01
Activation of the AP-1 family of transcription factors 10 2.43e-02 -4.11e-01 1.07e-01
Vitamin B1 (thiamin) metabolism 5 1.13e-01 -4.09e-01 2.86e-01
Glycosphingolipid transport 7 6.20e-02 -4.07e-01 1.94e-01
NFE2L2 regulating MDR associated enzymes 8 4.76e-02 4.05e-01 1.68e-01
Mitochondrial calcium ion transport 22 1.04e-03 -4.04e-01 1.24e-02
IRAK1 recruits IKK complex 14 9.11e-03 -4.03e-01 5.79e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 9.11e-03 -4.03e-01 5.79e-02
Maturation of hRSV A proteins 13 1.21e-02 -4.02e-01 6.98e-02
Lysosphingolipid and LPA receptors 11 2.13e-02 4.01e-01 1.01e-01
Regulation of TLR by endogenous ligand 15 7.18e-03 -4.01e-01 4.91e-02
Pentose phosphate pathway 13 1.25e-02 -4.00e-01 7.15e-02
Regulated proteolysis of p75NTR 11 2.36e-02 -3.94e-01 1.06e-01
Formation of the ureteric bud 5 1.29e-01 -3.92e-01 3.08e-01
Phospholipase C-mediated cascade; FGFR2 8 5.48e-02 3.92e-01 1.80e-01
Frs2-mediated activation 11 2.47e-02 -3.91e-01 1.08e-01
N-glycan trimming and elongation in the cis-Golgi 5 1.30e-01 -3.91e-01 3.10e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.01e-01 3.87e-01 2.68e-01
MyD88 deficiency (TLR2/4) 14 1.25e-02 -3.86e-01 7.15e-02
Alpha-oxidation of phytanate 6 1.02e-01 -3.85e-01 2.70e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 1.03e-01 -3.84e-01 2.71e-01
p75NTR negatively regulates cell cycle via SC1 5 1.37e-01 -3.84e-01 3.20e-01
Prolonged ERK activation events 13 1.67e-02 -3.83e-01 8.51e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 4.70e-02 3.82e-01 1.66e-01
Golgi Associated Vesicle Biogenesis 55 1.04e-06 -3.81e-01 5.90e-05
Synthesis of PIPs at the late endosome membrane 11 2.95e-02 -3.79e-01 1.20e-01
Norepinephrine Neurotransmitter Release Cycle 12 2.31e-02 3.79e-01 1.05e-01
p130Cas linkage to MAPK signaling for integrins 11 2.98e-02 -3.78e-01 1.20e-01
CS/DS degradation 9 5.12e-02 -3.75e-01 1.74e-01
Fatty acids 8 6.63e-02 3.75e-01 2.04e-01
Spry regulation of FGF signaling 16 9.60e-03 -3.74e-01 5.91e-02
Repression of WNT target genes 14 1.59e-02 3.72e-01 8.43e-02
STAT5 Activation 7 8.90e-02 -3.71e-01 2.48e-01
PI-3K cascade:FGFR3 10 4.25e-02 -3.70e-01 1.54e-01
Formation of annular gap junctions 10 4.34e-02 -3.69e-01 1.56e-01
The activation of arylsulfatases 10 4.39e-02 -3.68e-01 1.57e-01
Unwinding of DNA 12 2.77e-02 3.67e-01 1.15e-01
Glycosphingolipid catabolism 31 4.12e-04 -3.66e-01 6.20e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 1.57e-01 3.65e-01 3.49e-01
Transport and synthesis of PAPS 6 1.23e-01 -3.63e-01 3.00e-01
TYSND1 cleaves peroxisomal proteins 7 9.83e-02 -3.61e-01 2.63e-01
Propionyl-CoA catabolism 5 1.63e-01 -3.60e-01 3.58e-01
Voltage gated Potassium channels 27 1.21e-03 3.60e-01 1.41e-02
SARS-CoV-2 modulates autophagy 11 3.91e-02 -3.59e-01 1.45e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.25e-02 -3.56e-01 1.28e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 5.19e-02 -3.55e-01 1.75e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 6.58e-04 -3.53e-01 8.88e-03
Synthesis of PI 5 1.72e-01 3.53e-01 3.72e-01
RHO GTPases Activate WASPs and WAVEs 35 3.13e-04 -3.52e-01 5.11e-03
Downregulation of ERBB4 signaling 8 8.58e-02 -3.51e-01 2.41e-01
Processing of SMDT1 15 1.89e-02 -3.50e-01 9.25e-02
Nef mediated downregulation of MHC class I complex cell surface expression 10 5.58e-02 -3.49e-01 1.82e-01
Vitamin B2 (riboflavin) metabolism 6 1.39e-01 3.49e-01 3.22e-01
Sodium/Calcium exchangers 9 7.02e-02 -3.49e-01 2.11e-01
Lipophagy 7 1.11e-01 -3.48e-01 2.83e-01
Activated point mutants of FGFR2 7 1.17e-01 3.43e-01 2.90e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 9.36e-02 3.42e-01 2.57e-01
Cargo concentration in the ER 31 9.83e-04 -3.42e-01 1.20e-02
Signaling by TGF-beta Receptor Complex in Cancer 8 9.41e-02 -3.42e-01 2.57e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 2.23e-02 -3.41e-01 1.03e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 2.23e-02 -3.41e-01 1.03e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 2.23e-02 -3.41e-01 1.03e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 2.23e-02 -3.41e-01 1.03e-01
Signaling by CTNNB1 phospho-site mutants 15 2.23e-02 -3.41e-01 1.03e-01
Signaling by GSK3beta mutants 15 2.23e-02 -3.41e-01 1.03e-01
Prostanoid ligand receptors 8 9.55e-02 -3.40e-01 2.59e-01
Apoptotic factor-mediated response 19 1.08e-02 -3.38e-01 6.45e-02
Phase 3 - rapid repolarisation 6 1.53e-01 -3.37e-01 3.40e-01
Regulation of PTEN localization 9 8.10e-02 -3.36e-01 2.32e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 3.64e-02 -3.35e-01 1.38e-01
trans-Golgi Network Vesicle Budding 69 1.50e-06 -3.35e-01 8.25e-05
Branched-chain amino acid catabolism 21 7.97e-03 -3.34e-01 5.33e-02
Negative regulation of FGFR3 signaling 21 8.09e-03 -3.34e-01 5.36e-02
Defective CFTR causes cystic fibrosis 47 7.64e-05 -3.33e-01 1.64e-03
Trafficking and processing of endosomal TLR 13 3.75e-02 -3.33e-01 1.41e-01
Glucuronidation 8 1.03e-01 -3.33e-01 2.71e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.46e-02 -3.33e-01 7.91e-02
ERBB2 Regulates Cell Motility 10 6.91e-02 -3.32e-01 2.09e-01
RUNX3 regulates WNT signaling 8 1.05e-01 3.31e-01 2.72e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 1.08e-05 -3.31e-01 3.73e-04
GAB1 signalosome 14 3.21e-02 -3.31e-01 1.27e-01
RSK activation 7 1.30e-01 -3.30e-01 3.10e-01
Glycogen synthesis 11 5.80e-02 -3.30e-01 1.86e-01
p75NTR recruits signalling complexes 12 4.78e-02 -3.30e-01 1.68e-01
Suppression of phagosomal maturation 12 5.02e-02 -3.26e-01 1.74e-01
Signaling by LTK in cancer 7 1.35e-01 -3.26e-01 3.16e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.98e-03 -3.26e-01 1.97e-02
PI3K events in ERBB4 signaling 6 1.67e-01 -3.26e-01 3.63e-01
Ribosomal scanning and start codon recognition 58 1.82e-05 -3.25e-01 5.75e-04
Translation initiation complex formation 58 1.86e-05 -3.25e-01 5.77e-04
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 2.47e-02 -3.24e-01 1.08e-01
Synthesis of PIPs at the Golgi membrane 16 2.56e-02 -3.22e-01 1.10e-01
Synthesis of UDP-N-acetyl-glucosamine 8 1.16e-01 -3.21e-01 2.90e-01
Reversible hydration of carbon dioxide 8 1.16e-01 3.21e-01 2.90e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 9.64e-02 -3.20e-01 2.60e-01
SRP-dependent cotranslational protein targeting to membrane 110 6.98e-09 -3.20e-01 7.08e-07
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 6.66e-02 -3.19e-01 2.05e-01
Role of ABL in ROBO-SLIT signaling 6 1.77e-01 -3.18e-01 3.79e-01
Formation of ATP by chemiosmotic coupling 20 1.45e-02 -3.16e-01 7.91e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 3.44e-02 -3.16e-01 1.33e-01
Toxicity of botulinum toxin type D (botD) 5 2.22e-01 3.15e-01 4.33e-01
Toxicity of botulinum toxin type F (botF) 5 2.22e-01 3.15e-01 4.33e-01
FGFR1 mutant receptor activation 25 6.41e-03 -3.15e-01 4.56e-02
Synthesis of PIPs at the early endosome membrane 16 2.95e-02 -3.14e-01 1.20e-01
Aryl hydrocarbon receptor signalling 6 1.84e-01 -3.14e-01 3.88e-01
Neurotoxicity of clostridium toxins 8 1.26e-01 3.12e-01 3.06e-01
Signal attenuation 9 1.05e-01 -3.12e-01 2.73e-01
PINK1-PRKN Mediated Mitophagy 31 2.72e-03 -3.11e-01 2.51e-02
ER-Phagosome pathway 75 3.27e-06 -3.11e-01 1.54e-04
Cell recruitment (pro-inflammatory response) 25 7.21e-03 -3.10e-01 4.91e-02
Purinergic signaling in leishmaniasis infection 25 7.21e-03 -3.10e-01 4.91e-02
Zygotic genome activation (ZGA) 5 2.30e-01 3.10e-01 4.43e-01
Integration of provirus 9 1.08e-01 -3.10e-01 2.77e-01
Serotonin Neurotransmitter Release Cycle 13 5.32e-02 3.10e-01 1.78e-01
Defective factor IX causes hemophilia B 6 1.89e-01 3.09e-01 3.96e-01
Signaling by Hippo 18 2.31e-02 -3.09e-01 1.05e-01
MAP kinase activation 63 2.33e-05 -3.08e-01 6.84e-04
Citric acid cycle (TCA cycle) 34 1.96e-03 -3.07e-01 1.96e-02
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 5 2.39e-01 -3.04e-01 4.54e-01
Erythropoietin activates RAS 13 5.79e-02 -3.04e-01 1.86e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 8.11e-02 -3.04e-01 2.32e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 8.12e-02 -3.04e-01 2.32e-01
Signaling by CSF3 (G-CSF) 29 4.67e-03 -3.03e-01 3.60e-02
Endosomal/Vacuolar pathway 12 6.90e-02 -3.03e-01 2.09e-01
CREB3 factors activate genes 6 2.01e-01 -3.02e-01 4.10e-01
Prolactin receptor signaling 11 8.34e-02 -3.01e-01 2.38e-01
Beta-catenin phosphorylation cascade 17 3.14e-02 -3.01e-01 1.26e-01
APC truncation mutants have impaired AXIN binding 14 5.10e-02 -3.01e-01 1.74e-01
AXIN missense mutants destabilize the destruction complex 14 5.10e-02 -3.01e-01 1.74e-01
Signaling by AMER1 mutants 14 5.10e-02 -3.01e-01 1.74e-01
Signaling by APC mutants 14 5.10e-02 -3.01e-01 1.74e-01
Signaling by AXIN mutants 14 5.10e-02 -3.01e-01 1.74e-01
Truncations of AMER1 destabilize the destruction complex 14 5.10e-02 -3.01e-01 1.74e-01
RUNX3 regulates p14-ARF 10 9.92e-02 3.01e-01 2.64e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 2.73e-02 -3.00e-01 1.15e-01
Insulin receptor recycling 24 1.10e-02 -3.00e-01 6.53e-02
Hedgehog ligand biogenesis 47 3.80e-04 -3.00e-01 5.91e-03
NFE2L2 regulating tumorigenic genes 11 8.56e-02 2.99e-01 2.41e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 3.82e-02 -2.99e-01 1.43e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.34e-02 -2.98e-01 1.31e-01
Regulation of ornithine decarboxylase (ODC) 38 1.51e-03 -2.97e-01 1.61e-02
Inhibition of Signaling by Overexpressed EGFR 5 2.50e-01 -2.97e-01 4.62e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 2.50e-01 -2.97e-01 4.62e-01
NPAS4 regulates expression of target genes 16 4.04e-02 -2.96e-01 1.49e-01
L13a-mediated translational silencing of Ceruloplasmin expression 109 9.82e-08 -2.95e-01 7.97e-06
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 4.08e-02 -2.95e-01 1.50e-01
Creatine metabolism 6 2.11e-01 2.95e-01 4.22e-01
Apoptotic execution phase 46 5.45e-04 -2.95e-01 7.90e-03
Eicosanoid ligand-binding receptors 13 6.62e-02 -2.94e-01 2.04e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 9.75e-08 -2.94e-01 7.97e-06
Loss of Function of TGFBR1 in Cancer 7 1.79e-01 -2.93e-01 3.81e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.75e-02 -2.93e-01 8.75e-02
Hh mutants abrogate ligand secretion 43 9.06e-04 -2.92e-01 1.13e-02
Depolymerization of the Nuclear Lamina 15 5.02e-02 -2.92e-01 1.74e-01
Metabolism of polyamines 46 6.17e-04 -2.92e-01 8.55e-03
Synthesis of PE 12 8.10e-02 -2.91e-01 2.32e-01
NGF-stimulated transcription 32 4.44e-03 -2.91e-01 3.50e-02
Gap junction degradation 11 9.56e-02 -2.90e-01 2.59e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 7.00e-02 -2.90e-01 2.11e-01
Assembly of the ORC complex at the origin of replication 23 1.60e-02 -2.90e-01 8.43e-02
Axonal growth inhibition (RHOA activation) 7 1.85e-01 -2.89e-01 3.90e-01
p75NTR regulates axonogenesis 7 1.85e-01 -2.89e-01 3.90e-01
CTLA4 inhibitory signaling 21 2.19e-02 -2.89e-01 1.03e-01
Hh mutants are degraded by ERAD 42 1.21e-03 -2.89e-01 1.41e-02
Protein lipoylation 10 1.15e-01 -2.88e-01 2.88e-01
IKK complex recruitment mediated by RIP1 23 1.69e-02 -2.88e-01 8.52e-02
PI-3K cascade:FGFR1 13 7.23e-02 -2.88e-01 2.15e-01
Signaling by NODAL 15 5.37e-02 -2.88e-01 1.78e-01
Interleukin-6 signaling 11 9.90e-02 -2.87e-01 2.64e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 1.88e-01 2.87e-01 3.95e-01
Signaling by BRAF and RAF1 fusions 60 1.20e-04 -2.87e-01 2.36e-03
Synthesis of PA 31 5.68e-03 -2.87e-01 4.18e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 4.00e-04 -2.87e-01 6.16e-03
Signaling by Activin 13 7.47e-02 -2.86e-01 2.19e-01
Cap-dependent Translation Initiation 117 9.93e-08 -2.85e-01 7.97e-06
Eukaryotic Translation Initiation 117 9.93e-08 -2.85e-01 7.97e-06
Defective GALNT3 causes HFTC 9 1.39e-01 2.85e-01 3.22e-01
Synthesis of PC 23 1.81e-02 -2.85e-01 9.00e-02
Interleukin-17 signaling 68 4.92e-05 -2.85e-01 1.16e-03
MECP2 regulates transcription of neuronal ligands 5 2.72e-01 2.84e-01 4.84e-01
Platelet degranulation 105 5.42e-07 -2.83e-01 3.38e-05
Nuclear Events (kinase and transcription factor activation) 54 3.24e-04 -2.83e-01 5.21e-03
Negative regulation of FGFR4 signaling 22 2.18e-02 -2.83e-01 1.03e-01
Response to elevated platelet cytosolic Ca2+ 109 3.60e-07 -2.82e-01 2.40e-05
Tandem pore domain potassium channels 5 2.77e-01 -2.80e-01 4.88e-01
Formation of Incision Complex in GG-NER 43 1.46e-03 -2.80e-01 1.60e-02
Fructose metabolism 7 2.00e-01 -2.80e-01 4.08e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 9.34e-02 -2.80e-01 2.56e-01
alpha-linolenic acid (ALA) metabolism 12 9.34e-02 -2.80e-01 2.56e-01
Activation of the phototransduction cascade 9 1.47e-01 2.79e-01 3.33e-01
Free fatty acids regulate insulin secretion 10 1.27e-01 -2.79e-01 3.06e-01
RAF activation 33 5.57e-03 -2.79e-01 4.13e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.18e-02 -2.79e-01 1.94e-01
Formation of axial mesoderm 6 2.38e-01 2.78e-01 4.54e-01
Calcineurin activates NFAT 9 1.49e-01 -2.78e-01 3.36e-01
Lysosome Vesicle Biogenesis 32 6.92e-03 -2.76e-01 4.78e-02
GLI3 is processed to GLI3R by the proteasome 46 1.22e-03 -2.76e-01 1.41e-02
Tryptophan catabolism 12 9.86e-02 -2.75e-01 2.63e-01
The NLRP3 inflammasome 16 5.65e-02 -2.75e-01 1.83e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 2.89e-01 -2.74e-01 4.99e-01
HIV Transcription Initiation 45 1.49e-03 -2.74e-01 1.60e-02
RNA Polymerase II HIV Promoter Escape 45 1.49e-03 -2.74e-01 1.60e-02
RNA Polymerase II Promoter Escape 45 1.49e-03 -2.74e-01 1.60e-02
RNA Polymerase II Transcription Initiation 45 1.49e-03 -2.74e-01 1.60e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.49e-03 -2.74e-01 1.60e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.49e-03 -2.74e-01 1.60e-02
Folding of actin by CCT/TriC 10 1.34e-01 -2.73e-01 3.16e-01
Acetylcholine Neurotransmitter Release Cycle 10 1.35e-01 2.73e-01 3.16e-01
Regulation of signaling by NODAL 6 2.47e-01 -2.73e-01 4.61e-01
Interleukin-35 Signalling 12 1.02e-01 -2.73e-01 2.70e-01
Diseases associated with surfactant metabolism 5 2.91e-01 2.73e-01 4.99e-01
Transcriptional regulation of testis differentiation 5 2.91e-01 2.73e-01 4.99e-01
PERK regulates gene expression 31 8.75e-03 -2.72e-01 5.64e-02
Tie2 Signaling 16 6.01e-02 -2.71e-01 1.90e-01
Signal regulatory protein family interactions 13 9.02e-02 -2.71e-01 2.51e-01
ABC transporter disorders 60 2.82e-04 -2.71e-01 4.65e-03
Vpu mediated degradation of CD4 39 3.46e-03 -2.71e-01 2.92e-02
Degradation of GLI2 by the proteasome 45 1.69e-03 -2.71e-01 1.76e-02
Regulation of Apoptosis 40 3.08e-03 -2.70e-01 2.71e-02
RAB geranylgeranylation 63 2.06e-04 -2.70e-01 3.54e-03
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 1.17e-02 -2.70e-01 6.83e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 4.45e-03 -2.70e-01 3.50e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 4.72e-02 2.70e-01 1.67e-01
Loss of Function of SMAD2/3 in Cancer 7 2.16e-01 -2.70e-01 4.30e-01
Retrograde neurotrophin signalling 12 1.06e-01 -2.69e-01 2.74e-01
Interleukin-27 signaling 11 1.22e-01 -2.69e-01 2.97e-01
G beta:gamma signalling through CDC42 17 5.50e-02 -2.69e-01 1.80e-01
Deadenylation of mRNA 22 2.91e-02 -2.69e-01 1.19e-01
EPHB-mediated forward signaling 40 3.36e-03 -2.68e-01 2.89e-02
Retrograde transport at the Trans-Golgi-Network 49 1.21e-03 -2.67e-01 1.41e-02
Packaging Of Telomere Ends 18 4.97e-02 -2.67e-01 1.73e-01
VxPx cargo-targeting to cilium 19 4.40e-02 -2.67e-01 1.57e-01
LTC4-CYSLTR mediated IL4 production 5 3.03e-01 -2.66e-01 5.10e-01
Signal amplification 28 1.49e-02 -2.66e-01 8.04e-02
RHOBTB1 GTPase cycle 23 2.76e-02 -2.65e-01 1.15e-01
Sperm Motility And Taxes 6 2.61e-01 2.65e-01 4.71e-01
PI-3K cascade:FGFR4 11 1.29e-01 -2.65e-01 3.08e-01
Prevention of phagosomal-lysosomal fusion 9 1.70e-01 -2.64e-01 3.68e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 3.06e-03 -2.64e-01 2.70e-02
Signaling by FGFR1 in disease 32 9.73e-03 -2.64e-01 5.97e-02
Infection with Mycobacterium tuberculosis 26 1.98e-02 -2.64e-01 9.52e-02
Mucopolysaccharidoses 11 1.30e-01 -2.64e-01 3.10e-01
Methylation 13 1.00e-01 -2.63e-01 2.66e-01
CD28 dependent Vav1 pathway 12 1.14e-01 -2.63e-01 2.88e-01
Antigen processing-Cross presentation 89 1.78e-05 -2.63e-01 5.71e-04
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 6.87e-02 -2.63e-01 2.09e-01
Formation of a pool of free 40S subunits 99 6.17e-06 -2.63e-01 2.48e-04
Signaling by high-kinase activity BRAF mutants 33 8.96e-03 -2.63e-01 5.74e-02
Class I peroxisomal membrane protein import 20 4.19e-02 -2.63e-01 1.53e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 2.38e-06 -2.63e-01 1.18e-04
Toll Like Receptor TLR6:TLR2 Cascade 108 2.38e-06 -2.63e-01 1.18e-04
Acyl chain remodelling of PG 11 1.32e-01 -2.62e-01 3.12e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.63e-02 -2.62e-01 1.11e-01
Acetylcholine binding and downstream events 5 3.10e-01 2.62e-01 5.17e-01
Postsynaptic nicotinic acetylcholine receptors 5 3.10e-01 2.62e-01 5.17e-01
GRB2 events in EGFR signaling 10 1.52e-01 -2.62e-01 3.40e-01
Oncogenic MAPK signaling 76 8.14e-05 -2.61e-01 1.72e-03
Negative regulation of NOTCH4 signaling 44 2.76e-03 -2.61e-01 2.52e-02
Regulation of gene expression by Hypoxia-inducible Factor 8 2.02e-01 -2.61e-01 4.10e-01
Cargo trafficking to the periciliary membrane 48 1.80e-03 -2.60e-01 1.84e-02
activated TAK1 mediates p38 MAPK activation 23 3.08e-02 -2.60e-01 1.24e-01
Diseases of Mismatch Repair (MMR) 5 3.14e-01 -2.60e-01 5.21e-01
Signaling by BMP 23 3.14e-02 -2.59e-01 1.26e-01
G-protein beta:gamma signalling 29 1.60e-02 -2.58e-01 8.43e-02
ADP signalling through P2Y purinoceptor 12 18 5.81e-02 -2.58e-01 1.86e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 7.43e-02 -2.58e-01 2.18e-01
Biosynthesis of maresins 6 2.75e-01 2.57e-01 4.86e-01
Acyl chain remodelling of PE 20 4.68e-02 -2.57e-01 1.66e-01
Glycosphingolipid metabolism 46 2.59e-03 -2.57e-01 2.41e-02
Triglyceride catabolism 15 8.52e-02 -2.57e-01 2.40e-01
Negative regulation of FGFR1 signaling 25 2.64e-02 -2.57e-01 1.11e-01
Toll Like Receptor 2 (TLR2) Cascade 109 3.75e-06 -2.56e-01 1.61e-04
Toll Like Receptor TLR1:TLR2 Cascade 109 3.75e-06 -2.56e-01 1.61e-04
Neutrophil degranulation 456 7.36e-21 -2.56e-01 2.84e-18
Regulation of BACH1 activity 11 1.42e-01 -2.56e-01 3.26e-01
Association of TriC/CCT with target proteins during biosynthesis 35 8.87e-03 -2.56e-01 5.70e-02
ERK/MAPK targets 22 3.83e-02 -2.55e-01 1.43e-01
FGFR2 ligand binding and activation 9 1.85e-01 2.55e-01 3.91e-01
Degradation of AXIN 42 4.26e-03 -2.55e-01 3.43e-02
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 3.24e-01 2.55e-01 5.32e-01
Nucleotide catabolism 28 1.96e-02 -2.55e-01 9.51e-02
SHC1 events in ERBB4 signaling 10 1.63e-01 -2.55e-01 3.59e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.12e-01 -2.54e-01 2.85e-01
Interaction between L1 and Ankyrins 27 2.22e-02 2.54e-01 1.03e-01
CD163 mediating an anti-inflammatory response 9 1.87e-01 -2.54e-01 3.93e-01
HSF1-dependent transactivation 30 1.61e-02 2.54e-01 8.43e-02
SLBP independent Processing of Histone Pre-mRNAs 10 1.65e-01 -2.54e-01 3.61e-01
Activation of NF-kappaB in B cells 54 1.30e-03 -2.53e-01 1.47e-02
Synthesis of wybutosine at G37 of tRNA(Phe) 6 2.84e-01 -2.53e-01 4.95e-01
Termination of O-glycan biosynthesis 16 8.03e-02 2.53e-01 2.31e-01
AMPK inhibits chREBP transcriptional activation activity 6 2.84e-01 -2.52e-01 4.95e-01
Maturation of spike protein 9683686 5 3.29e-01 -2.52e-01 5.39e-01
SHC1 events in EGFR signaling 11 1.48e-01 -2.52e-01 3.34e-01
Degradation of GLI1 by the proteasome 46 3.16e-03 -2.52e-01 2.77e-02
Defective HLCS causes multiple carboxylase deficiency 7 2.49e-01 -2.52e-01 4.62e-01
Selenoamino acid metabolism 114 3.56e-06 -2.51e-01 1.60e-04
Activation of RAC1 downstream of NMDARs 7 2.50e-01 -2.51e-01 4.62e-01
mRNA Capping 29 1.93e-02 -2.51e-01 9.41e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 9.07e-06 -2.51e-01 3.30e-04
TRAIL signaling 8 2.20e-01 -2.50e-01 4.33e-01
Protein ubiquitination 71 2.69e-04 -2.50e-01 4.47e-03
MAPK6/MAPK4 signaling 69 3.35e-04 -2.50e-01 5.34e-03
Synthesis of PIPs at the plasma membrane 52 1.84e-03 -2.50e-01 1.88e-02
Kinesins 51 2.08e-03 2.49e-01 2.03e-02
Maturation of TCA enzymes and regulation of TCA cycle 20 5.40e-02 -2.49e-01 1.79e-01
Toll Like Receptor 9 (TLR9) Cascade 108 8.37e-06 -2.48e-01 3.15e-04
Ethanol oxidation 7 2.57e-01 -2.47e-01 4.67e-01
Platelet Adhesion to exposed collagen 15 9.82e-02 2.47e-01 2.63e-01
Signal transduction by L1 20 5.62e-02 -2.47e-01 1.82e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 5.79e-03 -2.46e-01 4.20e-02
Chemokine receptors bind chemokines 41 6.63e-03 2.45e-01 4.64e-02
PECAM1 interactions 12 1.42e-01 -2.45e-01 3.26e-01
MyD88 cascade initiated on plasma membrane 95 3.73e-05 -2.45e-01 9.59e-04
Toll Like Receptor 10 (TLR10) Cascade 95 3.73e-05 -2.45e-01 9.59e-04
Toll Like Receptor 5 (TLR5) Cascade 95 3.73e-05 -2.45e-01 9.59e-04
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 5.22e-02 -2.45e-01 1.75e-01
Inactivation of CDC42 and RAC1 7 2.62e-01 -2.45e-01 4.72e-01
RUNX1 regulates estrogen receptor mediated transcription 6 3.01e-01 2.44e-01 5.10e-01
Mitochondrial protein degradation 96 3.57e-05 -2.44e-01 9.56e-04
Vif-mediated degradation of APOBEC3G 41 6.85e-03 -2.44e-01 4.75e-02
Diseases of carbohydrate metabolism 29 2.30e-02 -2.44e-01 1.05e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 2.61e-03 -2.44e-01 2.41e-02
MET promotes cell motility 34 1.40e-02 -2.43e-01 7.73e-02
Ubiquitin-dependent degradation of Cyclin D 39 8.56e-03 -2.43e-01 5.58e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 1.15e-01 -2.43e-01 2.89e-01
2-LTR circle formation 7 2.65e-01 -2.43e-01 4.76e-01
Initiation of Nuclear Envelope (NE) Reformation 19 6.69e-02 -2.43e-01 2.06e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 2.72e-05 -2.43e-01 7.73e-04
ADP signalling through P2Y purinoceptor 1 21 5.47e-02 -2.42e-01 1.80e-01
Viral mRNA Translation 87 9.49e-05 -2.42e-01 1.97e-03
Synthesis of very long-chain fatty acyl-CoAs 22 4.95e-02 -2.42e-01 1.73e-01
Insulin processing 19 6.79e-02 -2.42e-01 2.08e-01
FOXO-mediated transcription of cell cycle genes 14 1.17e-01 -2.42e-01 2.92e-01
MAP2K and MAPK activation 36 1.24e-02 -2.41e-01 7.13e-02
RAF-independent MAPK1/3 activation 22 5.05e-02 -2.41e-01 1.74e-01
Mitophagy 38 1.02e-02 -2.41e-01 6.21e-02
RNA Polymerase I Promoter Escape 45 5.22e-03 -2.41e-01 3.91e-02
Acyl chain remodelling of PI 10 1.88e-01 -2.40e-01 3.95e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 9.59e-03 -2.40e-01 5.91e-02
p53-Independent DNA Damage Response 39 9.59e-03 -2.40e-01 5.91e-02
p53-Independent G1/S DNA damage checkpoint 39 9.59e-03 -2.40e-01 5.91e-02
Asymmetric localization of PCP proteins 49 3.76e-03 -2.39e-01 3.06e-02
Transcriptional Regulation by NPAS4 27 3.17e-02 -2.39e-01 1.27e-01
Formation of TC-NER Pre-Incision Complex 51 3.21e-03 -2.39e-01 2.79e-02
Smooth Muscle Contraction 34 1.62e-02 -2.38e-01 8.45e-02
Interleukin-21 signaling 9 2.18e-01 2.37e-01 4.30e-01
COPII-mediated vesicle transport 67 7.87e-04 -2.37e-01 1.01e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 4.69e-05 -2.37e-01 1.13e-03
Activation of RAC1 11 1.74e-01 -2.37e-01 3.74e-01
Peptide chain elongation 87 1.37e-04 -2.36e-01 2.56e-03
MyD88 dependent cascade initiated on endosome 101 4.23e-05 -2.36e-01 1.06e-03
Interleukin-1 signaling 99 5.14e-05 -2.35e-01 1.19e-03
Downstream signaling events of B Cell Receptor (BCR) 68 7.87e-04 -2.35e-01 1.01e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 8.87e-05 -2.35e-01 1.86e-03
Signaling by NTRK1 (TRKA) 102 4.07e-05 -2.35e-01 1.03e-03
Selenocysteine synthesis 91 1.07e-04 -2.35e-01 2.12e-03
Signaling by KIT in disease 20 6.89e-02 -2.35e-01 2.09e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.89e-02 -2.35e-01 2.09e-01
Aflatoxin activation and detoxification 14 1.28e-01 -2.35e-01 3.08e-01
MET receptor recycling 9 2.23e-01 -2.35e-01 4.33e-01
SIRT1 negatively regulates rRNA expression 22 5.70e-02 -2.34e-01 1.84e-01
Defects in biotin (Btn) metabolism 8 2.52e-01 -2.34e-01 4.63e-01
PTK6 Regulates Cell Cycle 6 3.23e-01 -2.33e-01 5.30e-01
Regulation of PTEN stability and activity 55 2.84e-03 -2.33e-01 2.57e-02
ERKs are inactivated 13 1.47e-01 -2.32e-01 3.33e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 1.55e-03 -2.32e-01 1.63e-02
BBSome-mediated cargo-targeting to cilium 23 5.39e-02 -2.32e-01 1.78e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 2.88e-01 -2.32e-01 4.98e-01
Defensins 8 2.56e-01 -2.32e-01 4.67e-01
Activated NTRK2 signals through FRS2 and FRS3 8 2.57e-01 -2.32e-01 4.67e-01
Signalling to ERKs 32 2.34e-02 -2.32e-01 1.05e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 37 1.48e-02 -2.32e-01 8.01e-02
RHOBTB GTPase Cycle 35 1.79e-02 -2.31e-01 8.92e-02
NFE2L2 regulating ER-stress associated genes 5 3.71e-01 2.31e-01 5.70e-01
Hydrolysis of LPC 8 2.58e-01 -2.31e-01 4.68e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 2.58e-01 -2.31e-01 4.68e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 2.30e-01 -2.31e-01 4.43e-01
Translation 292 1.15e-11 -2.31e-01 2.01e-09
COPI-independent Golgi-to-ER retrograde traffic 45 7.47e-03 -2.30e-01 5.03e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.68e-01 -2.30e-01 3.64e-01
Attachment of GPI anchor to uPAR 7 2.92e-01 -2.30e-01 5.00e-01
DARPP-32 events 22 6.18e-02 -2.30e-01 1.94e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 1.88e-02 -2.29e-01 9.25e-02
Stabilization of p53 43 9.27e-03 -2.29e-01 5.84e-02
RHOH GTPase cycle 33 2.26e-02 -2.29e-01 1.04e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.38e-01 2.29e-01 3.21e-01
APC/C:Cdc20 mediated degradation of Securin 55 3.32e-03 -2.29e-01 2.87e-02
Autodegradation of Cdh1 by Cdh1:APC/C 54 3.67e-03 -2.29e-01 3.04e-02
TGFBR3 regulates TGF-beta signaling 8 2.64e-01 -2.28e-01 4.74e-01
Cellular response to hypoxia 59 2.47e-03 -2.28e-01 2.32e-02
PI3K events in ERBB2 signaling 11 1.92e-01 -2.27e-01 3.97e-01
Regulation of RUNX3 expression and activity 45 8.34e-03 -2.27e-01 5.47e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.05e-01 -2.27e-01 2.72e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.57e-01 -2.27e-01 3.48e-01
ABC transporters in lipid homeostasis 14 1.42e-01 2.27e-01 3.26e-01
Eukaryotic Translation Termination 91 1.87e-04 -2.27e-01 3.33e-03
Diseases of hemostasis 14 1.42e-01 2.27e-01 3.26e-01
RNA Polymerase I Transcription Termination 30 3.22e-02 -2.26e-01 1.27e-01
Intra-Golgi traffic 43 1.04e-02 -2.26e-01 6.30e-02
M-decay: degradation of maternal mRNAs by maternally stored factors 41 1.24e-02 -2.26e-01 7.14e-02
Complex III assembly 23 6.12e-02 -2.26e-01 1.93e-01
Phosphorylation of Emi1 6 3.39e-01 2.25e-01 5.45e-01
Cytosolic sulfonation of small molecules 18 9.81e-02 -2.25e-01 2.63e-01
Toll-like Receptor Cascades 162 7.60e-07 -2.25e-01 4.58e-05
TP53 Regulates Metabolic Genes 78 5.88e-04 -2.25e-01 8.40e-03
Signaling by NOTCH4 68 1.36e-03 -2.25e-01 1.52e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 2.72e-01 -2.24e-01 4.83e-01
Triglyceride metabolism 24 5.71e-02 -2.24e-01 1.84e-01
Regulation of IFNG signaling 14 1.46e-01 -2.24e-01 3.32e-01
NIK–>noncanonical NF-kB signaling 46 8.57e-03 -2.24e-01 5.58e-02
Regulation of RUNX2 expression and activity 54 4.45e-03 -2.24e-01 3.50e-02
tRNA processing in the mitochondrion 24 5.84e-02 -2.23e-01 1.86e-01
Heme biosynthesis 13 1.64e-01 2.23e-01 3.60e-01
Josephin domain DUBs 10 2.23e-01 -2.23e-01 4.33e-01
Rap1 signalling 14 1.50e-01 -2.22e-01 3.36e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 4.55e-02 -2.22e-01 1.62e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.55e-02 -2.22e-01 1.62e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 5.96e-02 -2.22e-01 1.89e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 5.63e-03 -2.22e-01 4.16e-02
Maturation of spike protein 9694548 36 2.12e-02 -2.22e-01 1.00e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 2.03e-01 -2.22e-01 4.13e-01
p53-Dependent G1 DNA Damage Response 52 5.72e-03 -2.21e-01 4.18e-02
p53-Dependent G1/S DNA damage checkpoint 52 5.72e-03 -2.21e-01 4.18e-02
Eukaryotic Translation Elongation 92 2.41e-04 -2.21e-01 4.05e-03
Glycerophospholipid catabolism 7 3.12e-01 2.21e-01 5.19e-01
Proteasome assembly 51 6.47e-03 -2.20e-01 4.58e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.50e-01 -2.20e-01 5.54e-01
Reelin signalling pathway 5 3.94e-01 2.20e-01 5.94e-01
Listeria monocytogenes entry into host cells 17 1.17e-01 -2.20e-01 2.91e-01
ISG15 antiviral mechanism 72 1.28e-03 -2.19e-01 1.45e-02
Mitochondrial protein import 63 2.59e-03 -2.19e-01 2.41e-02
Influenza Infection 153 2.80e-06 -2.19e-01 1.35e-04
Autodegradation of the E3 ubiquitin ligase COP1 38 1.93e-02 -2.19e-01 9.41e-02
Activation of BAD and translocation to mitochondria 15 1.42e-01 -2.19e-01 3.26e-01
Detoxification of Reactive Oxygen Species 30 3.78e-02 -2.19e-01 1.42e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 3.53e-01 -2.19e-01 5.55e-01
Pexophagy 10 2.31e-01 -2.19e-01 4.44e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.54e-02 -2.19e-01 8.25e-02
Apoptotic cleavage of cellular proteins 35 2.55e-02 -2.18e-01 1.10e-01
CDK-mediated phosphorylation and removal of Cdc6 60 3.47e-03 -2.18e-01 2.92e-02
Erythropoietin activates Phospholipase C gamma (PLCG) 6 3.56e-01 -2.18e-01 5.57e-01
Negative epigenetic regulation of rRNA expression 63 2.82e-03 -2.18e-01 2.56e-02
TRIF-mediated programmed cell death 9 2.58e-01 -2.18e-01 4.68e-01
FasL/ CD95L signaling 5 4.00e-01 -2.17e-01 5.98e-01
Response to metal ions 6 3.56e-01 2.17e-01 5.58e-01
Cobalamin (Cbl) metabolism 7 3.19e-01 -2.17e-01 5.27e-01
NoRC negatively regulates rRNA expression 60 3.59e-03 -2.17e-01 3.01e-02
Diseases associated with N-glycosylation of proteins 20 9.26e-02 -2.17e-01 2.56e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 3.57e-01 -2.17e-01 5.59e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 1.46e-01 2.17e-01 3.32e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 1.08e-03 -2.17e-01 1.29e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 1.65e-02 -2.16e-01 8.47e-02
Signaling by RAS mutants 41 1.65e-02 -2.16e-01 8.47e-02
Signaling by moderate kinase activity BRAF mutants 41 1.65e-02 -2.16e-01 8.47e-02
Signaling downstream of RAS mutants 41 1.65e-02 -2.16e-01 8.47e-02
Acyl chain remodelling of PC 19 1.03e-01 -2.16e-01 2.71e-01
Post-transcriptional silencing by small RNAs 7 3.22e-01 -2.16e-01 5.30e-01
Signaling by ROBO receptors 188 3.26e-07 -2.16e-01 2.24e-05
p75NTR signals via NF-kB 15 1.48e-01 -2.16e-01 3.34e-01
Glycerophospholipid biosynthesis 105 1.34e-04 -2.16e-01 2.54e-03
RUNX3 regulates BCL2L11 (BIM) transcription 5 4.04e-01 -2.15e-01 6.01e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.24e-01 -2.15e-01 3.03e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 1.14e-01 2.15e-01 2.88e-01
G beta:gamma signalling through PLC beta 17 1.25e-01 -2.15e-01 3.04e-01
Presynaptic function of Kainate receptors 17 1.25e-01 -2.15e-01 3.04e-01
RHOBTB3 ATPase cycle 10 2.40e-01 -2.15e-01 4.55e-01
Transcription of the HIV genome 67 2.45e-03 -2.14e-01 2.32e-02
Activated NTRK2 signals through RAS 6 3.64e-01 -2.14e-01 5.64e-01
Activated NTRK3 signals through RAS 6 3.64e-01 -2.14e-01 5.64e-01
IRAK2 mediated activation of TAK1 complex 10 2.42e-01 -2.14e-01 4.57e-01
Ca2+ activated K+ channels 6 3.66e-01 2.13e-01 5.65e-01
Regulation of expression of SLITs and ROBOs 148 7.53e-06 -2.13e-01 2.90e-04
Signaling by ERBB2 44 1.45e-02 -2.13e-01 7.91e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 1.31e-04 -2.13e-01 2.54e-03
G1/S DNA Damage Checkpoints 54 6.80e-03 -2.13e-01 4.73e-02
Uptake of dietary cobalamins into enterocytes 6 3.68e-01 2.12e-01 5.67e-01
Mitotic Prophase 96 3.24e-04 -2.12e-01 5.21e-03
Cristae formation 33 3.52e-02 -2.12e-01 1.35e-01
mTORC1-mediated signalling 24 7.31e-02 -2.11e-01 2.16e-01
Acyl chain remodeling of CL 5 4.14e-01 -2.11e-01 6.12e-01
Cargo recognition for clathrin-mediated endocytosis 87 6.68e-04 -2.11e-01 8.88e-03
PI5P Regulates TP53 Acetylation 8 3.02e-01 -2.11e-01 5.10e-01
Protein localization 157 5.51e-06 -2.10e-01 2.26e-04
Transcriptional Regulation by E2F6 34 3.41e-02 -2.10e-01 1.33e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 4.94e-03 -2.10e-01 3.75e-02
Translation of Structural Proteins 9694635 56 6.65e-03 -2.10e-01 4.64e-02
Signaling by RAF1 mutants 37 2.76e-02 -2.09e-01 1.15e-01
Protein methylation 15 1.61e-01 -2.09e-01 3.55e-01
Interleukin-1 family signaling 127 4.76e-05 -2.09e-01 1.13e-03
Reactions specific to the complex N-glycan synthesis pathway 7 3.39e-01 -2.09e-01 5.45e-01
MECP2 regulates transcription factors 5 4.19e-01 -2.09e-01 6.15e-01
Activation of Ca-permeable Kainate Receptor 9 2.78e-01 2.09e-01 4.89e-01
Ionotropic activity of kainate receptors 9 2.78e-01 2.09e-01 4.89e-01
SUMOylation of RNA binding proteins 47 1.36e-02 -2.08e-01 7.64e-02
Regulation of CDH11 function 9 2.80e-01 2.08e-01 4.91e-01
SCF-beta-TrCP mediated degradation of Emi1 42 2.03e-02 -2.07e-01 9.69e-02
Response of Mtb to phagocytosis 22 9.31e-02 -2.07e-01 2.56e-01
Mitotic Telophase/Cytokinesis 13 1.97e-01 -2.06e-01 4.05e-01
Unfolded Protein Response (UPR) 85 9.99e-04 -2.06e-01 1.21e-02
Gastrin-CREB signalling pathway via PKC and MAPK 14 1.82e-01 -2.06e-01 3.86e-01
NS1 Mediated Effects on Host Pathways 40 2.41e-02 -2.06e-01 1.07e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 2.37e-01 -2.06e-01 4.52e-01
Hyaluronan uptake and degradation 12 2.17e-01 -2.06e-01 4.30e-01
Digestion 5 4.26e-01 2.05e-01 6.23e-01
CLEC7A (Dectin-1) signaling 86 1.01e-03 -2.05e-01 1.21e-02
Cellular response to starvation 147 1.78e-05 -2.05e-01 5.71e-04
Toll Like Receptor 4 (TLR4) Cascade 138 3.24e-05 -2.05e-01 8.89e-04
Interleukin-9 signaling 8 3.16e-01 2.05e-01 5.23e-01
Processing of Intronless Pre-mRNAs 20 1.13e-01 -2.05e-01 2.86e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 3.36e-02 -2.05e-01 1.31e-01
Postmitotic nuclear pore complex (NPC) reformation 27 6.58e-02 -2.05e-01 2.03e-01
HDL remodeling 6 3.86e-01 2.04e-01 5.85e-01
SARS-CoV-1 modulates host translation machinery 36 3.39e-02 -2.04e-01 1.33e-01
SHC1 events in ERBB2 signaling 17 1.46e-01 -2.04e-01 3.32e-01
RAS signaling downstream of NF1 loss-of-function variants 7 3.51e-01 -2.04e-01 5.54e-01
NOD1/2 Signaling Pathway 36 3.46e-02 -2.03e-01 1.34e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.22e-01 -2.03e-01 4.33e-01
Diseases associated with glycosaminoglycan metabolism 26 7.26e-02 -2.03e-01 2.15e-01
Late SARS-CoV-2 Infection Events 64 4.91e-03 -2.03e-01 3.74e-02
ATF4 activates genes in response to endoplasmic reticulum stress 26 7.28e-02 -2.03e-01 2.16e-01
Asparagine N-linked glycosylation 286 3.32e-09 -2.03e-01 4.00e-07
Attenuation phase 23 9.17e-02 2.03e-01 2.54e-01
Elevation of cytosolic Ca2+ levels 13 2.05e-01 2.03e-01 4.15e-01
Iron uptake and transport 52 1.15e-02 -2.03e-01 6.70e-02
Interleukin-2 signaling 11 2.46e-01 2.02e-01 4.60e-01
Influenza Viral RNA Transcription and Replication 134 5.33e-05 -2.02e-01 1.21e-03
Activation of the TFAP2 (AP-2) family of transcription factors 7 3.55e-01 2.02e-01 5.56e-01
SCF(Skp2)-mediated degradation of p27/p21 50 1.35e-02 -2.02e-01 7.64e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 6.41e-03 -2.02e-01 4.56e-02
Chaperone Mediated Autophagy 20 1.18e-01 -2.02e-01 2.92e-01
Interleukin-12 family signaling 53 1.11e-02 -2.02e-01 6.53e-02
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 3.94e-01 -2.01e-01 5.93e-01
TGFBR1 KD Mutants in Cancer 6 3.94e-01 -2.01e-01 5.93e-01
Interleukin-12 signaling 44 2.12e-02 -2.01e-01 1.00e-01
Sphingolipid metabolism 92 8.84e-04 -2.01e-01 1.11e-02
Peroxisomal protein import 58 8.31e-03 -2.00e-01 5.46e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 1.21e-01 -2.00e-01 2.97e-01
Pyrimidine salvage 10 2.73e-01 -2.00e-01 4.85e-01
Miro GTPase Cycle 8 3.30e-01 -1.99e-01 5.39e-01
Glutamate Neurotransmitter Release Cycle 19 1.33e-01 1.99e-01 3.14e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 2.34e-01 -1.98e-01 4.49e-01
Ephrin signaling 18 1.45e-01 -1.98e-01 3.32e-01
Activation of PUMA and translocation to mitochondria 9 3.03e-01 1.98e-01 5.11e-01
CD28 co-stimulation 33 4.89e-02 -1.98e-01 1.71e-01
Regulation of RAS by GAPs 55 1.11e-02 -1.98e-01 6.53e-02
Signaling by NTRKs 116 2.41e-04 -1.97e-01 4.05e-03
PD-1 signaling 28 7.08e-02 1.97e-01 2.12e-01
MyD88-independent TLR4 cascade 108 4.15e-04 -1.97e-01 6.20e-03
TRIF (TICAM1)-mediated TLR4 signaling 108 4.15e-04 -1.97e-01 6.20e-03
Degradation of DVL 43 2.57e-02 -1.97e-01 1.10e-01
Cellular responses to mechanical stimuli 82 2.10e-03 -1.96e-01 2.03e-02
Response of endothelial cells to shear stress 82 2.10e-03 -1.96e-01 2.03e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 1.74e-01 1.96e-01 3.74e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 1.87e-02 -1.96e-01 9.24e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 63 7.12e-03 -1.96e-01 4.90e-02
Signaling by FGFR3 32 5.52e-02 -1.96e-01 1.80e-01
Phosphorylation of the APC/C 20 1.30e-01 -1.96e-01 3.10e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 8.23e-03 -1.96e-01 5.43e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 1.13e-01 -1.95e-01 2.86e-01
EPH-Ephrin signaling 81 2.37e-03 -1.95e-01 2.26e-02
Clathrin-mediated endocytosis 126 1.55e-04 -1.95e-01 2.81e-03
Phospholipase C-mediated cascade; FGFR4 6 4.08e-01 1.95e-01 6.06e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 1.22e-01 -1.95e-01 2.97e-01
Neurodegenerative Diseases 21 1.22e-01 -1.95e-01 2.97e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.07e-01 -1.95e-01 4.16e-01
Ub-specific processing proteases 153 3.24e-05 -1.95e-01 8.89e-04
Na+/Cl- dependent neurotransmitter transporters 8 3.41e-01 1.94e-01 5.45e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 1.15e-01 -1.94e-01 2.88e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 1.43e-01 -1.94e-01 3.28e-01
Signaling by FGFR4 32 5.75e-02 -1.94e-01 1.85e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 76 3.46e-03 -1.94e-01 2.92e-02
Common Pathway of Fibrin Clot Formation 13 2.26e-01 -1.94e-01 4.38e-01
NrCAM interactions 6 4.11e-01 1.94e-01 6.09e-01
Signaling by Insulin receptor 63 7.88e-03 -1.94e-01 5.29e-02
RNA Polymerase I Promoter Opening 17 1.68e-01 -1.93e-01 3.64e-01
Synthesis, secretion, and deacylation of Ghrelin 11 2.69e-01 -1.92e-01 4.81e-01
Post-translational protein phosphorylation 67 6.49e-03 -1.92e-01 4.58e-02
Coenzyme A biosynthesis 7 3.79e-01 -1.92e-01 5.78e-01
Reduction of cytosolic Ca++ levels 9 3.19e-01 -1.92e-01 5.27e-01
Meiotic recombination 37 4.36e-02 -1.92e-01 1.57e-01
Nephron development 5 4.58e-01 1.92e-01 6.51e-01
RHOF GTPase cycle 38 4.10e-02 -1.92e-01 1.50e-01
Apoptosis 158 3.27e-05 -1.91e-01 8.89e-04
Integrin signaling 22 1.21e-01 -1.91e-01 2.97e-01
Complex IV assembly 45 2.66e-02 -1.91e-01 1.12e-01
Phospholipid metabolism 183 8.50e-06 -1.91e-01 3.15e-04
Early Phase of HIV Life Cycle 14 2.18e-01 -1.90e-01 4.30e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 2.55e-01 -1.90e-01 4.66e-01
O-glycosylation of TSR domain-containing proteins 28 8.22e-02 1.90e-01 2.35e-01
Dissolution of Fibrin Clot 12 2.55e-01 -1.90e-01 4.66e-01
C-type lectin receptors (CLRs) 118 3.80e-04 -1.89e-01 5.91e-03
MET activates PTK2 signaling 23 1.16e-01 -1.89e-01 2.90e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.73e-03 -1.89e-01 2.51e-02
Recognition of DNA damage by PCNA-containing replication complex 30 7.36e-02 -1.89e-01 2.17e-01
VEGFR2 mediated cell proliferation 18 1.66e-01 -1.89e-01 3.61e-01
VEGFA-VEGFR2 Pathway 92 1.78e-03 -1.88e-01 1.84e-02
WNT5A-dependent internalization of FZD4 13 2.40e-01 -1.88e-01 4.54e-01
Peroxisomal lipid metabolism 27 9.07e-02 -1.88e-01 2.52e-01
Keratan sulfate degradation 9 3.29e-01 -1.88e-01 5.39e-01
Signaling by Non-Receptor Tyrosine Kinases 47 2.61e-02 -1.88e-01 1.11e-01
Signaling by PTK6 47 2.61e-02 -1.88e-01 1.11e-01
OAS antiviral response 8 3.59e-01 -1.87e-01 5.60e-01
Recycling of bile acids and salts 10 3.05e-01 1.87e-01 5.12e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 4.69e-01 1.87e-01 6.59e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.16e-04 -1.86e-01 8.55e-03
Nonsense-Mediated Decay (NMD) 113 6.16e-04 -1.86e-01 8.55e-03
Phenylalanine and tyrosine metabolism 9 3.33e-01 1.86e-01 5.42e-01
Dual incision in TC-NER 63 1.06e-02 -1.86e-01 6.35e-02
VLDLR internalisation and degradation 15 2.13e-01 -1.86e-01 4.25e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 6.94e-02 -1.85e-01 2.09e-01
Metabolism of amino acids and derivatives 305 2.54e-08 -1.85e-01 2.44e-06
Inhibition of DNA recombination at telomere 33 6.54e-02 -1.85e-01 2.03e-01
Innate Immune System 970 1.33e-22 -1.85e-01 1.28e-19
Phase II - Conjugation of compounds 70 7.36e-03 -1.85e-01 4.98e-02
RNA Polymerase II Pre-transcription Events 77 5.03e-03 -1.85e-01 3.80e-02
Diseases associated with the TLR signaling cascade 29 8.49e-02 -1.85e-01 2.40e-01
Diseases of Immune System 29 8.49e-02 -1.85e-01 2.40e-01
FRS-mediated FGFR3 signaling 12 2.68e-01 -1.85e-01 4.80e-01
Defective B3GALTL causes PpS 27 9.68e-02 1.85e-01 2.61e-01
Bacterial Infection Pathways 65 1.01e-02 -1.85e-01 6.12e-02
HIV Infection 213 3.55e-06 -1.84e-01 1.60e-04
Platelet activation, signaling and aggregation 221 2.35e-06 -1.84e-01 1.18e-04
G beta:gamma signalling through PI3Kgamma 22 1.36e-01 -1.84e-01 3.17e-01
Glyoxylate metabolism and glycine degradation 13 2.51e-01 -1.84e-01 4.63e-01
Regulation of TP53 Activity through Phosphorylation 88 2.96e-03 -1.83e-01 2.65e-02
Host Interactions of HIV factors 118 5.84e-04 -1.83e-01 8.40e-03
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.28e-01 -1.83e-01 3.08e-01
Signaling by ALK 24 1.21e-01 1.83e-01 2.97e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 7.33e-02 -1.83e-01 2.17e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.47e-01 -1.83e-01 3.34e-01
Uptake and function of anthrax toxins 11 2.94e-01 -1.83e-01 5.04e-01
Class I MHC mediated antigen processing & presentation 345 5.64e-09 -1.83e-01 6.03e-07
Antiviral mechanism by IFN-stimulated genes 140 1.97e-04 -1.82e-01 3.41e-03
DNA Replication Pre-Initiation 103 1.40e-03 -1.82e-01 1.56e-02
Extra-nuclear estrogen signaling 65 1.11e-02 -1.82e-01 6.53e-02
Purine ribonucleoside monophosphate biosynthesis 9 3.44e-01 -1.82e-01 5.48e-01
Macroautophagy 128 3.79e-04 -1.82e-01 5.91e-03
Regulation of localization of FOXO transcription factors 12 2.76e-01 -1.82e-01 4.86e-01
DNA strand elongation 32 7.51e-02 1.82e-01 2.20e-01
SARS-CoV-2 Infection 267 3.16e-07 -1.82e-01 2.24e-05
SARS-CoV-2-host interactions 182 2.34e-05 -1.82e-01 6.84e-04
Aerobic respiration and respiratory electron transport 245 9.58e-07 -1.82e-01 5.60e-05
Condensation of Prophase Chromosomes 27 1.02e-01 -1.82e-01 2.70e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.20e-02 -1.81e-01 6.98e-02
Metabolism of proteins 1775 7.40e-37 -1.81e-01 1.43e-33
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 2.99e-01 -1.81e-01 5.08e-01
Downregulation of TGF-beta receptor signaling 26 1.10e-01 -1.81e-01 2.83e-01
Peptide hormone metabolism 53 2.28e-02 -1.81e-01 1.04e-01
Signaling by PDGFR in disease 19 1.74e-01 -1.80e-01 3.74e-01
RHO GTPases activate PKNs 46 3.47e-02 -1.80e-01 1.34e-01
Autophagy 142 2.18e-04 -1.80e-01 3.72e-03
Butyrophilin (BTN) family interactions 10 3.27e-01 1.79e-01 5.36e-01
Molybdenum cofactor biosynthesis 6 4.49e-01 -1.79e-01 6.43e-01
Thyroxine biosynthesis 5 4.90e-01 1.78e-01 6.71e-01
Signaling by VEGF 99 2.19e-03 -1.78e-01 2.11e-02
Metabolism of cofactors 25 1.23e-01 -1.78e-01 3.01e-01
G beta:gamma signalling through BTK 15 2.33e-01 -1.78e-01 4.48e-01
Programmed Cell Death 187 2.73e-05 -1.78e-01 7.73e-04
PI3K/AKT activation 8 3.84e-01 -1.78e-01 5.84e-01
FLT3 signaling by CBL mutants 7 4.16e-01 -1.77e-01 6.13e-01
Metabolic disorders of biological oxidation enzymes 23 1.41e-01 -1.77e-01 3.25e-01
Digestion and absorption 7 4.17e-01 1.77e-01 6.13e-01
GPER1 signaling 38 5.88e-02 -1.77e-01 1.87e-01
Type I hemidesmosome assembly 8 3.86e-01 1.77e-01 5.85e-01
Negative regulation of FGFR2 signaling 24 1.33e-01 -1.77e-01 3.14e-01
Intrinsic Pathway for Apoptosis 54 2.53e-02 -1.76e-01 1.10e-01
Assembly of the pre-replicative complex 87 4.55e-03 -1.76e-01 3.55e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 8.02e-03 -1.76e-01 5.35e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 2.29e-02 -1.76e-01 1.04e-01
Cellular responses to stimuli 778 7.28e-17 -1.76e-01 1.75e-14
Processing of Capped Intronless Pre-mRNA 29 1.02e-01 -1.76e-01 2.70e-01
Vitamin C (ascorbate) metabolism 8 3.90e-01 1.76e-01 5.89e-01
RAB GEFs exchange GTP for GDP on RABs 88 4.45e-03 -1.75e-01 3.50e-02
TRAF3-dependent IRF activation pathway 13 2.74e-01 1.75e-01 4.85e-01
Deadenylation-dependent mRNA decay 50 3.22e-02 -1.75e-01 1.27e-01
Signaling by FGFR3 in disease 14 2.57e-01 -1.75e-01 4.67e-01
Regulation of APC/C activators between G1/S and early anaphase 68 1.28e-02 -1.75e-01 7.28e-02
Toll Like Receptor 3 (TLR3) Cascade 104 2.20e-03 -1.74e-01 2.11e-02
Heme degradation 10 3.42e-01 1.74e-01 5.45e-01
Post-translational modification: synthesis of GPI-anchored proteins 60 2.00e-02 -1.74e-01 9.62e-02
ADORA2B mediated anti-inflammatory cytokines production 36 7.17e-02 -1.73e-01 2.14e-01
Regulation of KIT signaling 15 2.46e-01 -1.73e-01 4.60e-01
Selective autophagy 77 8.65e-03 -1.73e-01 5.62e-02
Cellular responses to stress 697 6.78e-15 -1.73e-01 1.31e-12
Glycogen metabolism 22 1.60e-01 -1.73e-01 3.55e-01
Metabolism of porphyrins 22 1.61e-01 1.72e-01 3.56e-01
Glycolysis 68 1.41e-02 -1.72e-01 7.77e-02
Proton-coupled monocarboxylate transport 6 4.66e-01 -1.72e-01 6.58e-01
DNA replication initiation 8 4.00e-01 -1.72e-01 5.99e-01
SUMOylation of intracellular receptors 26 1.30e-01 -1.72e-01 3.10e-01
Oncogene Induced Senescence 33 8.89e-02 -1.71e-01 2.48e-01
Signaling by SCF-KIT 40 6.14e-02 -1.71e-01 1.93e-01
Pyruvate metabolism 44 4.99e-02 -1.71e-01 1.73e-01
Signaling by EGFR in Cancer 22 1.66e-01 -1.71e-01 3.61e-01
Nuclear Envelope Breakdown 53 3.16e-02 -1.71e-01 1.27e-01
TICAM1-dependent activation of IRF3/IRF7 13 2.87e-01 1.71e-01 4.97e-01
Translocation of ZAP-70 to Immunological synapse 24 1.48e-01 1.70e-01 3.34e-01
Triglyceride biosynthesis 9 3.77e-01 -1.70e-01 5.77e-01
Ubiquinol biosynthesis 13 2.89e-01 -1.70e-01 4.99e-01
Regulation of TP53 Expression and Degradation 36 7.81e-02 -1.70e-01 2.26e-01
Neddylation 216 1.74e-05 -1.70e-01 5.71e-04
Early SARS-CoV-2 Infection Events 32 9.71e-02 -1.69e-01 2.61e-01
Prostacyclin signalling through prostacyclin receptor 16 2.42e-01 -1.69e-01 4.57e-01
MTOR signalling 39 6.81e-02 -1.69e-01 2.08e-01
Sphingolipid de novo biosynthesis 35 8.40e-02 -1.69e-01 2.39e-01
GRB2 events in ERBB2 signaling 11 3.34e-01 -1.68e-01 5.43e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 2.53e-02 -1.68e-01 1.10e-01
ER to Golgi Anterograde Transport 145 4.74e-04 -1.68e-01 6.97e-03
NF-kB is activated and signals survival 12 3.14e-01 -1.68e-01 5.20e-01
Regulation of signaling by CBL 22 1.73e-01 -1.68e-01 3.73e-01
Signaling by MET 68 1.67e-02 -1.68e-01 8.51e-02
DCC mediated attractive signaling 13 2.95e-01 -1.68e-01 5.04e-01
Myogenesis 20 1.94e-01 -1.68e-01 4.01e-01
rRNA processing in the nucleus and cytosol 189 7.42e-05 -1.67e-01 1.62e-03
Regulation of PTEN mRNA translation 13 2.97e-01 -1.67e-01 5.07e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 5.18e-01 -1.67e-01 6.92e-01
Signaling by ERBB4 45 5.30e-02 -1.67e-01 1.77e-01
SARS-CoV-1-host interactions 94 5.27e-03 -1.66e-01 3.94e-02
SOS-mediated signalling 7 4.46e-01 -1.66e-01 6.42e-01
IRE1alpha activates chaperones 46 5.11e-02 -1.66e-01 1.74e-01
FLT3 Signaling 38 7.63e-02 -1.66e-01 2.23e-01
Negative regulators of DDX58/IFIH1 signaling 34 9.39e-02 -1.66e-01 2.57e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 4.47e-01 1.66e-01 6.43e-01
Protein hydroxylation 17 2.37e-01 -1.66e-01 4.52e-01
Disorders of transmembrane transporters 136 8.45e-04 -1.66e-01 1.07e-02
Nuclear Envelope (NE) Reassembly 68 1.81e-02 -1.66e-01 9.00e-02
HIV Life Cycle 144 6.09e-04 -1.65e-01 8.55e-03
Translesion synthesis by POLI 17 2.38e-01 -1.65e-01 4.53e-01
Maturation of nucleoprotein 9683610 11 3.43e-01 -1.65e-01 5.47e-01
Defective pyroptosis 27 1.38e-01 -1.65e-01 3.21e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 8.72e-02 -1.65e-01 2.45e-01
Passive transport by Aquaporins 6 4.85e-01 -1.65e-01 6.70e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 2.49e-02 -1.65e-01 1.09e-01
SHC-mediated cascade:FGFR3 10 3.67e-01 -1.65e-01 5.67e-01
Recycling pathway of L1 40 7.17e-02 -1.65e-01 2.14e-01
Metabolism of nucleotides 85 8.75e-03 -1.64e-01 5.64e-02
Meiotic synapsis 43 6.21e-02 -1.64e-01 1.94e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 3.45e-01 -1.64e-01 5.49e-01
Defective EXT2 causes exostoses 2 11 3.45e-01 -1.64e-01 5.49e-01
Signaling by FGFR1 42 6.57e-02 -1.64e-01 2.03e-01
SUMOylation of chromatin organization proteins 57 3.22e-02 -1.64e-01 1.27e-01
Chaperonin-mediated protein folding 77 1.29e-02 -1.64e-01 7.31e-02
CD22 mediated BCR regulation 59 2.98e-02 1.64e-01 1.20e-01
Signaling by TGFBR3 39 7.72e-02 -1.64e-01 2.24e-01
Regulation of HMOX1 expression and activity 5 5.27e-01 -1.63e-01 6.98e-01
G2/M DNA replication checkpoint 5 5.28e-01 -1.63e-01 6.98e-01
Late Phase of HIV Life Cycle 131 1.26e-03 -1.63e-01 1.45e-02
SARS-CoV-1 Infection 137 9.78e-04 -1.63e-01 1.20e-02
Post-translational protein modification 1245 3.87e-22 -1.63e-01 2.49e-19
Adenylate cyclase activating pathway 8 4.26e-01 1.63e-01 6.23e-01
LDL clearance 17 2.46e-01 -1.62e-01 4.61e-01
Transcriptional regulation by small RNAs 61 2.83e-02 -1.62e-01 1.17e-01
KEAP1-NFE2L2 pathway 107 3.73e-03 -1.62e-01 3.05e-02
Azathioprine ADME 20 2.09e-01 -1.62e-01 4.20e-01
Oxidative Stress Induced Senescence 77 1.39e-02 -1.62e-01 7.69e-02
Major pathway of rRNA processing in the nucleolus and cytosol 179 1.84e-04 -1.62e-01 3.31e-03
DNA Damage Bypass 47 5.47e-02 -1.62e-01 1.80e-01
Formation of the beta-catenin:TCF transactivating complex 44 6.31e-02 1.62e-01 1.97e-01
Protein folding 83 1.08e-02 -1.62e-01 6.45e-02
Zinc transporters 12 3.32e-01 -1.62e-01 5.42e-01
Nucleotide Excision Repair 108 3.70e-03 -1.62e-01 3.05e-02
Gene Silencing by RNA 87 9.18e-03 -1.62e-01 5.80e-02
Respiratory electron transport 149 7.04e-04 -1.61e-01 9.21e-03
RNA Polymerase III Chain Elongation 18 2.39e-01 -1.60e-01 4.54e-01
APC/C-mediated degradation of cell cycle proteins 75 1.65e-02 -1.60e-01 8.47e-02
Regulation of mitotic cell cycle 75 1.65e-02 -1.60e-01 8.47e-02
Dual Incision in GG-NER 41 7.63e-02 -1.60e-01 2.23e-01
PI Metabolism 79 1.40e-02 -1.60e-01 7.73e-02
Budding and maturation of HIV virion 26 1.59e-01 -1.60e-01 3.52e-01
Metal ion SLC transporters 19 2.28e-01 -1.60e-01 4.42e-01
Androgen biosynthesis 5 5.37e-01 -1.59e-01 7.05e-01
Signaling by ERBB2 in Cancer 21 2.06e-01 -1.59e-01 4.16e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 4.66e-01 -1.59e-01 6.58e-01
Transport of the SLBP independent Mature mRNA 35 1.04e-01 -1.59e-01 2.71e-01
Formation of definitive endoderm 9 4.09e-01 -1.59e-01 6.07e-01
Disorders of Developmental Biology 12 3.41e-01 1.59e-01 5.45e-01
Disorders of Nervous System Development 12 3.41e-01 1.59e-01 5.45e-01
Loss of function of MECP2 in Rett syndrome 12 3.41e-01 1.59e-01 5.45e-01
Pervasive developmental disorders 12 3.41e-01 1.59e-01 5.45e-01
Membrane Trafficking 574 8.00e-11 -1.59e-01 1.19e-08
Transferrin endocytosis and recycling 26 1.63e-01 -1.58e-01 3.58e-01
Regulation of TP53 Degradation 35 1.06e-01 -1.58e-01 2.74e-01
Induction of Cell-Cell Fusion 8 4.40e-01 -1.58e-01 6.35e-01
Inflammasomes 21 2.11e-01 -1.58e-01 4.22e-01
Signaling by EGFR 47 6.14e-02 -1.58e-01 1.93e-01
EGFR downregulation 26 1.65e-01 -1.57e-01 3.60e-01
Recycling of eIF2:GDP 8 4.41e-01 -1.57e-01 6.37e-01
Activation of SMO 14 3.09e-01 1.57e-01 5.16e-01
B-WICH complex positively regulates rRNA expression 45 6.87e-02 -1.57e-01 2.09e-01
Transport to the Golgi and subsequent modification 171 4.04e-04 -1.57e-01 6.18e-03
Hedgehog ‘on’ state 66 2.77e-02 -1.57e-01 1.15e-01
PCP/CE pathway 75 1.90e-02 -1.57e-01 9.28e-02
tRNA processing in the nucleus 59 3.74e-02 -1.57e-01 1.41e-01
Downstream signaling of activated FGFR3 17 2.64e-01 -1.57e-01 4.74e-01
Nuclear import of Rev protein 34 1.14e-01 -1.56e-01 2.88e-01
Glutamate and glutamine metabolism 12 3.48e-01 -1.56e-01 5.52e-01
Regulation of NF-kappa B signaling 18 2.51e-01 -1.56e-01 4.63e-01
GABA synthesis, release, reuptake and degradation 11 3.71e-01 1.56e-01 5.70e-01
Nonhomologous End-Joining (NHEJ) 40 8.81e-02 -1.56e-01 2.47e-01
Degradation of beta-catenin by the destruction complex 72 2.24e-02 -1.56e-01 1.03e-01
Regulation of NPAS4 gene expression 11 3.72e-01 -1.55e-01 5.71e-01
Sema4D mediated inhibition of cell attachment and migration 7 4.77e-01 -1.55e-01 6.64e-01
Mitotic Anaphase 211 1.06e-04 -1.55e-01 2.12e-03
POLB-Dependent Long Patch Base Excision Repair 8 4.49e-01 1.55e-01 6.43e-01
Signaling by Erythropoietin 24 1.90e-01 -1.55e-01 3.96e-01
rRNA processing 213 1.02e-04 -1.54e-01 2.08e-03
Cross-presentation of particulate exogenous antigens (phagosomes) 8 4.50e-01 -1.54e-01 6.43e-01
Polo-like kinase mediated events 16 2.86e-01 1.54e-01 4.96e-01
tRNA modification in the mitochondrion 9 4.24e-01 -1.54e-01 6.22e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.52e-01 -1.54e-01 3.40e-01
Vpr-mediated nuclear import of PICs 34 1.21e-01 -1.54e-01 2.97e-01
Synthesis of IP3 and IP4 in the cytosol 22 2.13e-01 -1.53e-01 4.25e-01
Biosynthesis of DHA-derived SPMs 14 3.21e-01 1.53e-01 5.29e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 2.90e-01 1.53e-01 4.99e-01
Activation of NOXA and translocation to mitochondria 5 5.54e-01 1.53e-01 7.18e-01
Methionine salvage pathway 6 5.18e-01 -1.53e-01 6.92e-01
rRNA modification in the nucleus and cytosol 60 4.10e-02 -1.52e-01 1.50e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.38e-01 -1.52e-01 4.54e-01
Synthesis of PG 8 4.56e-01 -1.52e-01 6.50e-01
Somitogenesis 41 9.31e-02 -1.52e-01 2.56e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 3.85e-01 -1.51e-01 5.84e-01
Interactions of Vpr with host cellular proteins 37 1.11e-01 -1.51e-01 2.83e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 5.25e-02 -1.51e-01 1.76e-01
Mitotic Metaphase and Anaphase 212 1.50e-04 -1.51e-01 2.75e-03
Drug-mediated inhibition of CDK4/CDK6 activity 5 5.59e-01 1.51e-01 7.21e-01
Nuclear events mediated by NFE2L2 82 1.82e-02 -1.51e-01 9.02e-02
RNA Polymerase III Transcription Termination 22 2.21e-01 -1.51e-01 4.33e-01
Negative regulation of MAPK pathway 42 9.11e-02 -1.51e-01 2.53e-01
RHO GTPases activate IQGAPs 25 1.92e-01 -1.51e-01 3.97e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 4.34e-01 1.51e-01 6.31e-01
Meiosis 67 3.31e-02 -1.51e-01 1.30e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.40e-01 -1.51e-01 3.25e-01
RNA polymerase II transcribes snRNA genes 71 2.83e-02 -1.51e-01 1.17e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.73e-02 -1.50e-01 1.15e-01
Downstream TCR signaling 89 1.42e-02 -1.50e-01 7.81e-02
FRS-mediated FGFR1 signaling 15 3.14e-01 -1.50e-01 5.20e-01
Signaling by PDGF 48 7.18e-02 -1.50e-01 2.14e-01
Infectious disease 958 3.83e-15 -1.50e-01 8.20e-13
Organic anion transporters 7 4.94e-01 1.49e-01 6.74e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 3.72e-01 1.49e-01 5.71e-01
Switching of origins to a post-replicative state 79 2.22e-02 -1.49e-01 1.03e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 3.54e-01 -1.49e-01 5.55e-01
Complex I biogenesis 66 3.70e-02 -1.48e-01 1.40e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 3.36e-01 -1.48e-01 5.44e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.82e-01 -1.48e-01 3.86e-01
Caspase activation via Death Receptors in the presence of ligand 16 3.05e-01 -1.48e-01 5.12e-01
Nuclear signaling by ERBB4 24 2.10e-01 -1.48e-01 4.21e-01
Cellular response to chemical stress 179 6.43e-04 -1.48e-01 8.85e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.76e-01 -1.48e-01 3.77e-01
SUMOylation of ubiquitinylation proteins 39 1.12e-01 -1.47e-01 2.85e-01
Fatty acyl-CoA biosynthesis 35 1.32e-01 -1.47e-01 3.12e-01
Deubiquitination 225 1.44e-04 -1.47e-01 2.67e-03
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.78e-01 -1.47e-01 3.80e-01
Transport of the SLBP Dependant Mature mRNA 36 1.27e-01 -1.47e-01 3.06e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 1.04e-01 -1.47e-01 2.71e-01
RHOQ GTPase cycle 54 6.23e-02 -1.47e-01 1.94e-01
RHO GTPases Activate ROCKs 18 2.82e-01 -1.46e-01 4.93e-01
Glucagon signaling in metabolic regulation 26 1.96e-01 -1.46e-01 4.03e-01
Translesion synthesis by POLK 17 2.97e-01 -1.46e-01 5.06e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.10e-01 -1.46e-01 2.82e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 2.59e-01 -1.46e-01 4.68e-01
mRNA 3’-end processing 57 5.68e-02 -1.46e-01 1.84e-01
Role of second messengers in netrin-1 signaling 6 5.36e-01 1.46e-01 7.05e-01
Separation of Sister Chromatids 168 1.12e-03 -1.46e-01 1.32e-02
Transcription of E2F targets under negative control by DREAM complex 19 2.73e-01 1.45e-01 4.84e-01
PKR-mediated signaling 67 3.97e-02 -1.45e-01 1.47e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 2.86e-01 -1.45e-01 4.96e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 2.86e-01 -1.45e-01 4.96e-01
ABC-family proteins mediated transport 81 2.39e-02 -1.45e-01 1.07e-01
Myoclonic epilepsy of Lafora 8 4.77e-01 -1.45e-01 6.64e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.50e-01 -1.45e-01 4.62e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.50e-01 -1.45e-01 4.62e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 3.86e-01 1.44e-01 5.85e-01
Circadian Clock 67 4.21e-02 -1.44e-01 1.53e-01
Signaling by TGFB family members 137 3.73e-03 -1.44e-01 3.05e-02
Signaling by FLT3 ITD and TKD mutants 15 3.36e-01 -1.43e-01 5.44e-01
ESR-mediated signaling 157 1.93e-03 -1.43e-01 1.95e-02
Insulin receptor signalling cascade 40 1.17e-01 -1.43e-01 2.91e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 6.60e-04 -1.43e-01 8.88e-03
ALK mutants bind TKIs 11 4.12e-01 -1.43e-01 6.10e-01
Downregulation of ERBB2 signaling 24 2.26e-01 -1.43e-01 4.38e-01
UCH proteinases 73 3.50e-02 -1.43e-01 1.35e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 3.92e-01 -1.43e-01 5.92e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 2.39e-02 -1.43e-01 1.07e-01
Uptake and function of diphtheria toxin 6 5.46e-01 -1.42e-01 7.14e-01
rRNA modification in the mitochondrion 8 4.86e-01 1.42e-01 6.70e-01
Cleavage of the damaged purine 22 2.48e-01 -1.42e-01 4.62e-01
Depurination 22 2.48e-01 -1.42e-01 4.62e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 2.48e-01 -1.42e-01 4.62e-01
PRC2 methylates histones and DNA 27 2.01e-01 -1.42e-01 4.10e-01
Respiratory syncytial virus (RSV) attachment and entry 19 2.83e-01 -1.42e-01 4.94e-01
Impaired BRCA2 binding to PALB2 24 2.29e-01 -1.42e-01 4.42e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 4.87e-01 -1.42e-01 6.70e-01
RHOD GTPase cycle 49 8.57e-02 -1.42e-01 2.41e-01
Degradation of cysteine and homocysteine 12 3.95e-01 -1.42e-01 5.94e-01
Maturation of protein 3a 9683673 9 4.61e-01 1.42e-01 6.54e-01
Maturation of protein 3a 9694719 9 4.61e-01 1.42e-01 6.54e-01
Metabolism of RNA 717 1.05e-10 -1.42e-01 1.45e-08
Thrombin signalling through proteinase activated receptors (PARs) 27 2.03e-01 -1.41e-01 4.13e-01
RNA Polymerase I Promoter Clearance 64 5.04e-02 -1.41e-01 1.74e-01
RNA Polymerase I Transcription 64 5.04e-02 -1.41e-01 1.74e-01
Syndecan interactions 25 2.21e-01 -1.41e-01 4.33e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 5.49e-01 1.41e-01 7.15e-01
Amyloid fiber formation 51 8.08e-02 -1.41e-01 2.32e-01
RNA Polymerase II Transcription Termination 66 4.73e-02 -1.41e-01 1.67e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 2.04e-01 -1.41e-01 4.14e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 4.77e-02 -1.41e-01 1.68e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.05e-01 -1.41e-01 4.15e-01
Inwardly rectifying K+ channels 23 2.42e-01 -1.41e-01 4.57e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.44e-01 -1.41e-01 3.29e-01
Processing of Capped Intron-Containing Pre-mRNA 279 5.23e-05 -1.41e-01 1.20e-03
Viral Infection Pathways 775 2.89e-11 -1.40e-01 4.64e-09
Glucose metabolism 76 3.44e-02 -1.40e-01 1.33e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 5.21e-01 -1.40e-01 6.95e-01
TGF-beta receptor signaling activates SMADs 45 1.04e-01 -1.40e-01 2.71e-01
SUMOylation of immune response proteins 12 4.02e-01 1.40e-01 5.99e-01
Cellular hexose transport 15 3.50e-01 1.39e-01 5.54e-01
ROS and RNS production in phagocytes 30 1.87e-01 -1.39e-01 3.93e-01
APOBEC3G mediated resistance to HIV-1 infection 5 5.90e-01 1.39e-01 7.45e-01
Diseases of signal transduction by growth factor receptors and second messengers 401 1.81e-06 -1.39e-01 9.70e-05
Signaling by Receptor Tyrosine Kinases 443 5.44e-07 -1.39e-01 3.38e-05
Orc1 removal from chromatin 58 6.75e-02 -1.39e-01 2.07e-01
VEGFR2 mediated vascular permeability 25 2.30e-01 -1.39e-01 4.43e-01
Opioid Signalling 75 3.80e-02 -1.39e-01 1.43e-01
eNOS activation 11 4.26e-01 -1.39e-01 6.23e-01
Maturation of nucleoprotein 9694631 15 3.53e-01 -1.38e-01 5.55e-01
Cellular Senescence 143 4.29e-03 -1.38e-01 3.43e-02
E2F-enabled inhibition of pre-replication complex formation 9 4.72e-01 -1.38e-01 6.61e-01
Signaling by FGFR in disease 52 8.45e-02 -1.38e-01 2.39e-01
Cleavage of the damaged pyrimidine 27 2.14e-01 -1.38e-01 4.25e-01
Depyrimidination 27 2.14e-01 -1.38e-01 4.25e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 2.14e-01 -1.38e-01 4.25e-01
Metalloprotease DUBs 20 2.84e-01 -1.38e-01 4.95e-01
XBP1(S) activates chaperone genes 44 1.13e-01 -1.38e-01 2.86e-01
Amino acids regulate mTORC1 48 9.84e-02 -1.38e-01 2.63e-01
Constitutive Signaling by Overexpressed ERBB2 11 4.29e-01 -1.38e-01 6.25e-01
RET signaling 32 1.77e-01 -1.38e-01 3.79e-01
DNA Damage Recognition in GG-NER 38 1.42e-01 -1.38e-01 3.26e-01
G2/M DNA damage checkpoint 66 5.34e-02 -1.37e-01 1.78e-01
Cyclin E associated events during G1/S transition 73 4.23e-02 -1.37e-01 1.54e-01
Neurofascin interactions 5 5.95e-01 1.37e-01 7.49e-01
Mitochondrial biogenesis 91 2.38e-02 -1.37e-01 1.07e-01
Signaling by Hedgehog 121 9.31e-03 -1.37e-01 5.84e-02
Phase 0 - rapid depolarisation 24 2.46e-01 1.37e-01 4.60e-01
Transcriptional regulation by RUNX2 89 2.60e-02 -1.37e-01 1.11e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 4.80e-01 -1.36e-01 6.65e-01
Neurotransmitter clearance 5 5.98e-01 -1.36e-01 7.50e-01
Formation of the Early Elongation Complex 33 1.76e-01 -1.36e-01 3.77e-01
Formation of the HIV-1 Early Elongation Complex 33 1.76e-01 -1.36e-01 3.77e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 1.01e-04 -1.36e-01 2.08e-03
Acyl chain remodelling of PS 14 3.79e-01 -1.36e-01 5.78e-01
Inositol phosphate metabolism 42 1.28e-01 -1.36e-01 3.08e-01
Glycogen storage diseases 13 3.97e-01 -1.36e-01 5.96e-01
Transport of vitamins, nucleosides, and related molecules 31 1.92e-01 -1.36e-01 3.97e-01
CHL1 interactions 8 5.07e-01 1.36e-01 6.83e-01
Metabolism 1827 7.79e-22 -1.35e-01 3.75e-19
Activation of BH3-only proteins 30 2.00e-01 -1.35e-01 4.08e-01
Negative regulation of the PI3K/AKT network 91 2.57e-02 -1.35e-01 1.10e-01
Transport of Mature Transcript to Cytoplasm 81 3.54e-02 -1.35e-01 1.35e-01
Metabolism of lipids 641 5.15e-09 -1.35e-01 5.84e-07
SUMOylation of SUMOylation proteins 35 1.67e-01 -1.35e-01 3.63e-01
Vesicle-mediated transport 665 2.90e-09 -1.35e-01 3.72e-07
LGI-ADAM interactions 9 4.83e-01 1.35e-01 6.68e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 5.27e-02 -1.35e-01 1.77e-01
Constitutive Signaling by EGFRvIII 14 3.82e-01 -1.35e-01 5.82e-01
Signaling by EGFRvIII in Cancer 14 3.82e-01 -1.35e-01 5.82e-01
Heme signaling 45 1.18e-01 -1.35e-01 2.92e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.31e-01 -1.35e-01 3.11e-01
HIV Transcription Elongation 42 1.31e-01 -1.35e-01 3.11e-01
Tat-mediated elongation of the HIV-1 transcript 42 1.31e-01 -1.35e-01 3.11e-01
APC-Cdc20 mediated degradation of Nek2A 26 2.36e-01 -1.34e-01 4.51e-01
Plasma lipoprotein assembly 10 4.62e-01 -1.34e-01 6.54e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.45e-01 -1.34e-01 4.60e-01
Maternal to zygotic transition (MZT) 72 4.91e-02 -1.34e-01 1.72e-01
Signaling by NTRK2 (TRKB) 20 2.99e-01 -1.34e-01 5.09e-01
Pyroptosis 25 2.46e-01 -1.34e-01 4.60e-01
Sulfur amino acid metabolism 22 2.77e-01 -1.34e-01 4.88e-01
Regulation of HSF1-mediated heat shock response 79 3.99e-02 -1.34e-01 1.47e-01
DNA Damage/Telomere Stress Induced Senescence 42 1.34e-01 -1.34e-01 3.15e-01
Physiological factors 9 4.88e-01 1.34e-01 6.70e-01
Synthesis of Dolichyl-phosphate 6 5.71e-01 -1.33e-01 7.31e-01
Diseases associated with O-glycosylation of proteins 50 1.03e-01 1.33e-01 2.71e-01
Beta-catenin independent WNT signaling 126 9.81e-03 -1.33e-01 6.00e-02
DNA Replication 128 9.36e-03 -1.33e-01 5.86e-02
Xenobiotics 12 4.25e-01 1.33e-01 6.23e-01
RAC3 GTPase cycle 87 3.21e-02 -1.33e-01 1.27e-01
Homologous DNA Pairing and Strand Exchange 43 1.32e-01 -1.33e-01 3.12e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 1.28e-01 -1.33e-01 3.08e-01
MHC class II antigen presentation 113 1.49e-02 -1.33e-01 8.02e-02
Gamma-carboxylation of protein precursors 6 5.74e-01 1.33e-01 7.32e-01
Mitochondrial translation 96 2.51e-02 -1.32e-01 1.09e-01
Dectin-2 family 19 3.18e-01 -1.32e-01 5.26e-01
COPI-mediated anterograde transport 92 2.85e-02 -1.32e-01 1.17e-01
Signaling by Leptin 10 4.70e-01 -1.32e-01 6.59e-01
RHO GTPases activate PAKs 20 3.08e-01 -1.32e-01 5.14e-01
RHOBTB2 GTPase cycle 23 2.74e-01 -1.32e-01 4.85e-01
Dopamine Neurotransmitter Release Cycle 18 3.34e-01 1.32e-01 5.43e-01
STAT3 nuclear events downstream of ALK signaling 11 4.50e-01 1.31e-01 6.43e-01
Disease 1623 1.17e-18 -1.31e-01 3.74e-16
Synthesis of 15-eicosatetraenoic acid derivatives 6 5.78e-01 -1.31e-01 7.34e-01
Fructose catabolism 5 6.11e-01 -1.31e-01 7.61e-01
Generation of second messenger molecules 38 1.63e-01 1.31e-01 3.58e-01
Downstream signal transduction 27 2.41e-01 -1.30e-01 4.55e-01
Serine biosynthesis 8 5.23e-01 -1.30e-01 6.96e-01
Interleukin-7 signaling 21 3.02e-01 1.30e-01 5.10e-01
Metabolism of carbohydrates 241 5.21e-04 -1.30e-01 7.61e-03
TNFR1-induced proapoptotic signaling 24 2.72e-01 1.30e-01 4.83e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.51e-01 -1.30e-01 3.38e-01
Diseases of DNA Double-Strand Break Repair 41 1.51e-01 -1.30e-01 3.38e-01
Cell Cycle Checkpoints 246 4.66e-04 -1.30e-01 6.90e-03
SHC-mediated cascade:FGFR1 13 4.19e-01 -1.29e-01 6.15e-01
Interactions of Rev with host cellular proteins 37 1.73e-01 -1.29e-01 3.73e-01
PIP3 activates AKT signaling 234 6.52e-04 -1.29e-01 8.88e-03
Signaling by TGF-beta Receptor Complex 90 3.42e-02 -1.29e-01 1.33e-01
Processive synthesis on the lagging strand 15 3.87e-01 1.29e-01 5.85e-01
mRNA Splicing - Major Pathway 203 1.53e-03 -1.29e-01 1.62e-02
Regulation of TP53 Activity 153 5.99e-03 -1.29e-01 4.29e-02
Formation of RNA Pol II elongation complex 56 9.64e-02 -1.28e-01 2.60e-01
RNA Polymerase II Transcription Elongation 56 9.64e-02 -1.28e-01 2.60e-01
Fatty acid metabolism 157 5.53e-03 -1.28e-01 4.11e-02
G2/M Checkpoints 126 1.29e-02 -1.28e-01 7.31e-02
Lysine catabolism 11 4.63e-01 -1.28e-01 6.54e-01
Defective B4GALT7 causes EDS, progeroid type 12 4.43e-01 -1.28e-01 6.40e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.52e-01 -1.28e-01 3.40e-01
STAT5 activation downstream of FLT3 ITD mutants 9 5.08e-01 -1.27e-01 6.84e-01
TNFs bind their physiological receptors 25 2.71e-01 1.27e-01 4.83e-01
Regulation of pyruvate metabolism 32 2.13e-01 -1.27e-01 4.25e-01
Defective GALNT12 causes CRCS1 9 5.09e-01 1.27e-01 6.85e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 3.97e-01 -1.26e-01 5.96e-01
Chondroitin sulfate biosynthesis 12 4.49e-01 -1.26e-01 6.43e-01
RHOJ GTPase cycle 49 1.26e-01 -1.26e-01 3.06e-01
G-protein activation 19 3.41e-01 -1.26e-01 5.45e-01
Nucleotide-like (purinergic) receptors 14 4.14e-01 -1.26e-01 6.12e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 9.50e-02 -1.26e-01 2.59e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.34e-01 -1.26e-01 4.49e-01
Mitochondrial RNA degradation 25 2.78e-01 -1.25e-01 4.88e-01
Interconversion of nucleotide di- and triphosphates 27 2.60e-01 -1.25e-01 4.68e-01
Phosphorylation of CD3 and TCR zeta chains 27 2.60e-01 1.25e-01 4.68e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 2.98e-01 -1.25e-01 5.08e-01
SUMOylation of transcription cofactors 44 1.51e-01 -1.25e-01 3.38e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 2.52e-01 -1.25e-01 4.63e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.20e-01 -1.25e-01 2.97e-01
CLEC7A (Dectin-1) induces NFAT activation 11 4.75e-01 -1.24e-01 6.63e-01
E2F mediated regulation of DNA replication 22 3.13e-01 -1.24e-01 5.20e-01
EGFR interacts with phospholipase C-gamma 6 5.98e-01 -1.24e-01 7.50e-01
Thromboxane signalling through TP receptor 20 3.37e-01 -1.24e-01 5.44e-01
Sulfide oxidation to sulfate 5 6.31e-01 -1.24e-01 7.78e-01
Viral Messenger RNA Synthesis 44 1.55e-01 -1.24e-01 3.44e-01
Export of Viral Ribonucleoproteins from Nucleus 33 2.18e-01 -1.24e-01 4.30e-01
HCMV Late Events 67 7.95e-02 -1.24e-01 2.30e-01
mRNA Splicing 211 1.94e-03 -1.24e-01 1.95e-02
HATs acetylate histones 92 4.02e-02 -1.24e-01 1.48e-01
M Phase 346 7.60e-05 -1.24e-01 1.64e-03
Fertilization 13 4.40e-01 1.24e-01 6.35e-01
Immune System 1841 1.43e-18 -1.24e-01 3.94e-16
Signaling by Nuclear Receptors 210 2.04e-03 -1.23e-01 2.02e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 2.20e-01 -1.23e-01 4.33e-01
Hedgehog ‘off’ state 92 4.14e-02 -1.23e-01 1.51e-01
GPVI-mediated activation cascade 32 2.29e-01 -1.23e-01 4.42e-01
Synthesis of diphthamide-EEF2 8 5.48e-01 -1.23e-01 7.15e-01
Synthesis of bile acids and bile salts 26 2.79e-01 -1.23e-01 4.89e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 6.81e-02 -1.23e-01 2.08e-01
FGFR1b ligand binding and activation 5 6.35e-01 1.23e-01 7.81e-01
Nuclear events stimulated by ALK signaling in cancer 33 2.23e-01 1.23e-01 4.34e-01
RHO GTPase Effectors 259 6.86e-04 -1.23e-01 9.05e-03
RAC2 GTPase cycle 85 5.14e-02 -1.22e-01 1.74e-01
CLEC7A/inflammasome pathway 6 6.05e-01 -1.22e-01 7.55e-01
ROBO receptors bind AKAP5 7 5.76e-01 -1.22e-01 7.34e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 5.77e-01 1.22e-01 7.34e-01
HS-GAG degradation 20 3.47e-01 -1.22e-01 5.50e-01
Regulation of CDH11 mRNA translation by microRNAs 8 5.53e-01 -1.21e-01 7.18e-01
Regulation of NPAS4 mRNA translation 8 5.53e-01 -1.21e-01 7.18e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.51e-01 -1.21e-01 4.62e-01
Cytosolic iron-sulfur cluster assembly 13 4.50e-01 1.21e-01 6.43e-01
PTEN Regulation 127 1.87e-02 -1.21e-01 9.24e-02
Signaling by PDGFRA extracellular domain mutants 12 4.70e-01 -1.20e-01 6.59e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 4.70e-01 -1.20e-01 6.59e-01
Potassium Channels 64 9.65e-02 1.20e-01 2.60e-01
Nervous system development 478 6.86e-06 -1.20e-01 2.70e-04
Signaling by WNT in cancer 30 2.55e-01 -1.20e-01 4.66e-01
tRNA processing 128 1.94e-02 -1.20e-01 9.42e-02
Chromatin modifications during the maternal to zygotic transition (MZT) 23 3.21e-01 -1.20e-01 5.29e-01
Defective Intrinsic Pathway for Apoptosis 24 3.12e-01 -1.19e-01 5.19e-01
Mitochondrial translation initiation 90 5.17e-02 -1.19e-01 1.74e-01
Surfactant metabolism 20 3.58e-01 -1.19e-01 5.60e-01
Interferon Signaling 240 1.55e-03 -1.19e-01 1.63e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.79e-01 -1.18e-01 3.81e-01
Nitric oxide stimulates guanylate cyclase 15 4.28e-01 1.18e-01 6.25e-01
Translesion synthesis by REV1 16 4.13e-01 -1.18e-01 6.11e-01
Rab regulation of trafficking 121 2.47e-02 -1.18e-01 1.08e-01
Organelle biogenesis and maintenance 278 7.08e-04 -1.18e-01 9.21e-03
Leishmania infection 213 3.05e-03 -1.18e-01 2.70e-02
Parasitic Infection Pathways 213 3.05e-03 -1.18e-01 2.70e-02
Signaling by ERBB2 KD Mutants 20 3.63e-01 -1.18e-01 5.63e-01
Signaling by FGFR4 in disease 11 5.00e-01 -1.18e-01 6.78e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 6.18e-01 1.17e-01 7.67e-01
Signaling by FGFR2 61 1.13e-01 -1.17e-01 2.86e-01
FGFR2c ligand binding and activation 5 6.50e-01 1.17e-01 7.90e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 2.53e-01 -1.17e-01 4.64e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 2.53e-01 -1.17e-01 4.64e-01
SUMOylation of DNA damage response and repair proteins 77 7.69e-02 -1.17e-01 2.24e-01
Transcriptional Regulation by TP53 346 1.96e-04 -1.17e-01 3.41e-03
Ketone body metabolism 8 5.68e-01 -1.16e-01 7.29e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 2.10e-01 -1.16e-01 4.21e-01
RHOV GTPase cycle 36 2.28e-01 -1.16e-01 4.42e-01
Axon guidance 459 2.09e-05 -1.16e-01 6.38e-04
MicroRNA (miRNA) biogenesis 24 3.26e-01 -1.16e-01 5.36e-01
RHOG GTPase cycle 70 9.42e-02 -1.16e-01 2.57e-01
Mitotic Spindle Checkpoint 108 3.81e-02 -1.15e-01 1.43e-01
Cyclin A:Cdk2-associated events at S phase entry 75 8.44e-02 -1.15e-01 2.39e-01
IRF3-mediated induction of type I IFN 12 4.90e-01 -1.15e-01 6.71e-01
RHO GTPases Activate NADPH Oxidases 22 3.50e-01 -1.15e-01 5.54e-01
Downstream signaling of activated FGFR1 22 3.52e-01 -1.15e-01 5.55e-01
Keratan sulfate biosynthesis 20 3.75e-01 1.15e-01 5.75e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.75e-01 -1.14e-01 6.63e-01
TCR signaling 110 3.83e-02 -1.14e-01 1.43e-01
Diseases of programmed cell death 58 1.33e-01 -1.14e-01 3.13e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 7.15e-02 1.14e-01 2.14e-01
Nef Mediated CD4 Down-regulation 9 5.56e-01 -1.13e-01 7.19e-01
Gap junction assembly 17 4.18e-01 1.13e-01 6.15e-01
Regulated Necrosis 56 1.45e-01 -1.12e-01 3.32e-01
SARS-CoV Infections 434 5.93e-05 -1.12e-01 1.33e-03
Purine catabolism 16 4.38e-01 -1.12e-01 6.34e-01
FGFR2 alternative splicing 25 3.33e-01 -1.12e-01 5.42e-01
Respiratory Syncytial Virus Infection Pathway 99 5.44e-02 -1.12e-01 1.80e-01
Cytosolic tRNA aminoacylation 24 3.43e-01 -1.12e-01 5.47e-01
Mitochondrial translation termination 90 6.73e-02 -1.12e-01 2.06e-01
Intracellular signaling by second messengers 267 1.74e-03 -1.11e-01 1.80e-02
RUNX2 regulates genes involved in cell migration 6 6.39e-01 -1.11e-01 7.83e-01
Golgi-to-ER retrograde transport 123 3.41e-02 -1.11e-01 1.33e-01
Interleukin receptor SHC signaling 23 3.59e-01 1.10e-01 5.60e-01
HDR through Single Strand Annealing (SSA) 37 2.46e-01 -1.10e-01 4.60e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 3.41e-01 -1.10e-01 5.45e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 3.41e-01 -1.10e-01 5.45e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 3.41e-01 -1.10e-01 5.45e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 3.41e-01 -1.10e-01 5.45e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 3.51e-01 -1.10e-01 5.54e-01
Resolution of Sister Chromatid Cohesion 116 4.13e-02 -1.10e-01 1.51e-01
FRS-mediated FGFR4 signaling 13 4.95e-01 -1.09e-01 6.74e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 4.50e-01 1.09e-01 6.43e-01
Telomere C-strand synthesis initiation 13 4.97e-01 -1.09e-01 6.77e-01
P2Y receptors 10 5.54e-01 -1.08e-01 7.18e-01
Platelet homeostasis 69 1.21e-01 -1.08e-01 2.97e-01
Cyclin D associated events in G1 47 2.01e-01 -1.08e-01 4.10e-01
G1 Phase 47 2.01e-01 -1.08e-01 4.10e-01
Cilium Assembly 187 1.11e-02 -1.08e-01 6.53e-02
EPH-ephrin mediated repulsion of cells 43 2.22e-01 -1.08e-01 4.33e-01
Mitochondrial translation elongation 90 7.79e-02 -1.08e-01 2.26e-01
Long-term potentiation 18 4.30e-01 1.07e-01 6.26e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.57e-01 -1.07e-01 7.20e-01
TAK1-dependent IKK and NF-kappa-B activation 43 2.25e-01 -1.07e-01 4.36e-01
MITF-M-regulated melanocyte development 113 4.99e-02 -1.07e-01 1.73e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.70e-01 -1.06e-01 4.82e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 6.81e-01 -1.06e-01 8.12e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 6.81e-01 -1.06e-01 8.12e-01
Defects in vitamin and cofactor metabolism 21 4.01e-01 -1.06e-01 5.99e-01
DNA Repair 289 1.96e-03 -1.06e-01 1.96e-02
p38MAPK events 13 5.10e-01 -1.05e-01 6.86e-01
Fc epsilon receptor (FCERI) signaling 180 1.55e-02 -1.05e-01 8.25e-02
Pregnenolone biosynthesis 10 5.68e-01 1.04e-01 7.29e-01
Metabolism of non-coding RNA 53 1.90e-01 -1.04e-01 3.96e-01
snRNP Assembly 53 1.90e-01 -1.04e-01 3.96e-01
Biotin transport and metabolism 11 5.50e-01 -1.04e-01 7.17e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.70e-01 -1.04e-01 7.30e-01
Formation of tubulin folding intermediates by CCT/TriC 21 4.10e-01 -1.04e-01 6.08e-01
Nucleotide biosynthesis 12 5.34e-01 -1.04e-01 7.03e-01
Downstream signaling of activated FGFR4 18 4.46e-01 -1.04e-01 6.42e-01
mRNA Editing 8 6.11e-01 1.04e-01 7.61e-01
NR1H2 and NR1H3-mediated signaling 38 2.70e-01 -1.03e-01 4.82e-01
Impaired BRCA2 binding to RAD51 35 2.90e-01 -1.03e-01 4.99e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 6.62e-01 1.03e-01 7.98e-01
Alpha-protein kinase 1 signaling pathway 11 5.54e-01 -1.03e-01 7.18e-01
Transcriptional activation of mitochondrial biogenesis 52 1.99e-01 -1.03e-01 4.08e-01
Other interleukin signaling 19 4.38e-01 1.03e-01 6.34e-01
Signaling by NOTCH 173 1.97e-02 -1.03e-01 9.52e-02
Signaling by activated point mutants of FGFR1 5 6.91e-01 -1.03e-01 8.16e-01
SUMOylation of DNA methylation proteins 16 4.78e-01 -1.03e-01 6.64e-01
Phase 2 - plateau phase 11 5.57e-01 -1.02e-01 7.20e-01
RUNX3 regulates CDKN1A transcription 7 6.39e-01 1.02e-01 7.84e-01
SUMOylation of transcription factors 16 4.79e-01 -1.02e-01 6.65e-01
WNT ligand biogenesis and trafficking 20 4.29e-01 -1.02e-01 6.26e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 4.69e-01 1.01e-01 6.59e-01
Glutathione conjugation 27 3.62e-01 -1.01e-01 5.62e-01
FLT3 signaling in disease 27 3.62e-01 -1.01e-01 5.63e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 6.43e-01 1.01e-01 7.85e-01
EGFR Transactivation by Gastrin 7 6.43e-01 -1.01e-01 7.85e-01
Ion transport by P-type ATPases 44 2.46e-01 1.01e-01 4.60e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.46e-01 -1.01e-01 6.42e-01
Defective RIPK1-mediated regulated necrosis 7 6.45e-01 1.01e-01 7.87e-01
Synthesis of substrates in N-glycan biosythesis 59 1.82e-01 -1.00e-01 3.86e-01
Rev-mediated nuclear export of HIV RNA 35 3.04e-01 -1.00e-01 5.11e-01
Telomere Extension By Telomerase 23 4.05e-01 -1.00e-01 6.02e-01
Reproduction 86 1.09e-01 -9.99e-02 2.81e-01
Senescence-Associated Secretory Phenotype (SASP) 65 1.64e-01 -9.97e-02 3.60e-01
Biological oxidations 143 3.99e-02 -9.95e-02 1.47e-01
A tetrasaccharide linker sequence is required for GAG synthesis 18 4.66e-01 -9.93e-02 6.58e-01
Aquaporin-mediated transport 38 2.90e-01 -9.92e-02 4.99e-01
Negative regulation of MET activity 18 4.66e-01 -9.92e-02 6.58e-01
Scavenging by Class A Receptors 12 5.53e-01 -9.88e-02 7.18e-01
G-protein mediated events 44 2.58e-01 -9.85e-02 4.68e-01
SUMOylation 167 2.83e-02 -9.83e-02 1.17e-01
CDH11 homotypic and heterotypic interactions 5 7.04e-01 -9.82e-02 8.23e-01
SARS-CoV-1 activates/modulates innate immune responses 40 2.83e-01 -9.81e-02 4.94e-01
Signaling by Interleukins 390 9.29e-04 -9.77e-02 1.15e-02
Activation of NMDA receptors and postsynaptic events 74 1.48e-01 -9.72e-02 3.34e-01
Formation of the cornified envelope 37 3.06e-01 -9.72e-02 5.13e-01
Regulation of TP53 Activity through Acetylation 29 3.66e-01 9.70e-02 5.66e-01
Interleukin-23 signaling 7 6.58e-01 -9.67e-02 7.94e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 6.58e-01 9.66e-02 7.94e-01
HDR through Homologous Recombination (HRR) 68 1.68e-01 -9.66e-02 3.65e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.92e-01 -9.66e-02 3.97e-01
PI3K Cascade 31 3.52e-01 -9.65e-02 5.55e-01
Displacement of DNA glycosylase by APEX1 9 6.16e-01 9.65e-02 7.66e-01
Fanconi Anemia Pathway 36 3.16e-01 -9.65e-02 5.24e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 6.38e-01 9.62e-02 7.83e-01
Formation of the nephric duct 8 6.39e-01 9.59e-02 7.83e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 623 4.50e-05 -9.57e-02 1.10e-03
Transcriptional regulation by RUNX3 80 1.40e-01 -9.54e-02 3.25e-01
Collagen biosynthesis and modifying enzymes 46 2.65e-01 -9.49e-02 4.76e-01
IkBA variant leads to EDA-ID 7 6.64e-01 9.49e-02 7.99e-01
RIPK1-mediated regulated necrosis 31 3.61e-01 -9.48e-02 5.62e-01
Regulation of necroptotic cell death 31 3.61e-01 -9.48e-02 5.62e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 1.18e-01 -9.48e-02 2.92e-01
Amplification of signal from the kinetochores 91 1.18e-01 -9.48e-02 2.92e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 3.12e-01 -9.48e-02 5.19e-01
Cell-extracellular matrix interactions 15 5.25e-01 -9.48e-02 6.96e-01
Erythrocytes take up carbon dioxide and release oxygen 11 5.87e-01 9.47e-02 7.41e-01
O2/CO2 exchange in erythrocytes 11 5.87e-01 9.47e-02 7.41e-01
IRS-mediated signalling 35 3.34e-01 -9.44e-02 5.43e-01
Positive epigenetic regulation of rRNA expression 60 2.06e-01 -9.44e-02 4.16e-01
G1/S Transition 120 7.42e-02 -9.44e-02 2.18e-01
Diseases of metabolism 204 2.12e-02 -9.36e-02 1.00e-01
Translesion Synthesis by POLH 18 4.92e-01 -9.36e-02 6.73e-01
Adaptive Immune System 771 1.02e-05 -9.34e-02 3.63e-04
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 5.60e-01 9.34e-02 7.22e-01
TRAF6 mediated NF-kB activation 23 4.38e-01 -9.34e-02 6.34e-01
G alpha (z) signalling events 36 3.32e-01 -9.34e-02 5.42e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 4.93e-01 9.33e-02 6.73e-01
FOXO-mediated transcription 58 2.19e-01 -9.33e-02 4.31e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 5.46e-01 -9.33e-02 7.14e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 5.46e-01 9.33e-02 7.14e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 3.33e-01 -9.33e-02 5.42e-01
Organic cation transport 8 6.48e-01 -9.31e-02 7.89e-01
Organic cation/anion/zwitterion transport 8 6.48e-01 -9.31e-02 7.89e-01
Histidine catabolism 7 6.70e-01 -9.31e-02 8.03e-01
NFE2L2 regulates pentose phosphate pathway genes 8 6.50e-01 -9.27e-02 7.90e-01
Cytokine Signaling in Immune system 668 4.45e-05 -9.26e-02 1.10e-03
Metabolism of steroids 123 7.71e-02 -9.23e-02 2.24e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 5.96e-01 9.23e-02 7.49e-01
Metabolism of folate and pterines 16 5.24e-01 -9.21e-02 6.96e-01
Signaling by FLT3 fusion proteins 18 5.01e-01 -9.15e-02 6.79e-01
Signaling by MAPK mutants 6 6.99e-01 -9.13e-02 8.21e-01
Synthesis of DNA 108 1.02e-01 -9.11e-02 2.70e-01
HCMV Infection 106 1.06e-01 -9.10e-02 2.74e-01
Cytoprotection by HMOX1 53 2.53e-01 -9.08e-02 4.64e-01
Activation of HOX genes during differentiation 70 1.89e-01 -9.08e-02 3.96e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 1.89e-01 -9.08e-02 3.96e-01
Signaling by Rho GTPases 607 1.35e-04 -9.07e-02 2.54e-03
S Phase 150 5.58e-02 -9.05e-02 1.82e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.61e-01 -9.05e-02 5.62e-01
Signaling by WNT 240 1.59e-02 -9.04e-02 8.43e-02
Interleukin-6 family signaling 20 4.86e-01 -9.01e-02 6.70e-01
RUNX3 Regulates Immune Response and Cell Migration 5 7.27e-01 -9.00e-02 8.41e-01
Sensing of DNA Double Strand Breaks 6 7.03e-01 -8.98e-02 8.23e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 3.65e-01 -8.97e-02 5.65e-01
Interleukin-20 family signaling 17 5.22e-01 8.96e-02 6.96e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 4.57e-01 -8.96e-02 6.50e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 4.57e-01 -8.96e-02 6.50e-01
Base-Excision Repair, AP Site Formation 29 4.04e-01 -8.96e-02 6.01e-01
PKA-mediated phosphorylation of CREB 17 5.24e-01 -8.92e-02 6.96e-01
RNA Polymerase I Transcription Initiation 47 2.90e-01 -8.92e-02 4.99e-01
HDMs demethylate histones 22 4.70e-01 8.91e-02 6.59e-01
Class B/2 (Secretin family receptors) 57 2.45e-01 8.90e-02 4.60e-01
Formation of paraxial mesoderm 52 2.68e-01 -8.88e-02 4.80e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 7.31e-01 -8.88e-02 8.44e-01
HDR through MMEJ (alt-NHEJ) 12 5.95e-01 8.86e-02 7.49e-01
Signaling by FGFR 73 1.91e-01 -8.86e-02 3.96e-01
Signalling to RAS 19 5.05e-01 -8.84e-02 6.82e-01
Intraflagellar transport 47 2.95e-01 -8.84e-02 5.04e-01
Ca2+ pathway 58 2.47e-01 -8.78e-02 4.62e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 5.21e-01 -8.74e-02 6.95e-01
Late endosomal microautophagy 30 4.08e-01 -8.73e-02 6.06e-01
RHO GTPases Activate Formins 128 8.82e-02 -8.73e-02 2.47e-01
Translation of Structural Proteins 9683701 29 4.17e-01 -8.72e-02 6.13e-01
FGFR4 ligand binding and activation 5 7.38e-01 8.63e-02 8.45e-01
Synaptic adhesion-like molecules 17 5.38e-01 8.62e-02 7.06e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 3.02e-01 -8.61e-02 5.10e-01
Gastrulation 76 1.95e-01 -8.61e-02 4.01e-01
Diseases of DNA repair 51 2.88e-01 -8.60e-02 4.98e-01
SHC-mediated cascade:FGFR2 13 5.92e-01 8.58e-02 7.47e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 5.29e-01 -8.56e-02 6.99e-01
Signaling by NOTCH3 42 3.37e-01 -8.56e-02 5.44e-01
RHOT2 GTPase cycle 7 6.96e-01 -8.53e-02 8.19e-01
Ovarian tumor domain proteases 37 3.69e-01 -8.53e-02 5.69e-01
Processing of DNA double-strand break ends 69 2.21e-01 -8.52e-02 4.33e-01
Regulation of TP53 Activity through Methylation 19 5.25e-01 -8.43e-02 6.96e-01
RHO GTPase cycle 411 3.40e-03 -8.42e-02 2.90e-02
Signaling by FGFR2 IIIa TM 18 5.37e-01 -8.41e-02 7.05e-01
Mitotic G1 phase and G1/S transition 138 8.91e-02 -8.38e-02 2.48e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 3.05e-01 8.38e-02 5.12e-01
Linoleic acid (LA) metabolism 7 7.02e-01 -8.36e-02 8.23e-01
FCGR3A-mediated phagocytosis 122 1.11e-01 -8.35e-02 2.83e-01
Leishmania phagocytosis 122 1.11e-01 -8.35e-02 2.83e-01
Parasite infection 122 1.11e-01 -8.35e-02 2.83e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 7.02e-01 -8.35e-02 8.23e-01
Effects of PIP2 hydrolysis 24 4.81e-01 8.31e-02 6.66e-01
Removal of the Flap Intermediate 14 5.91e-01 8.31e-02 7.45e-01
Pre-NOTCH Expression and Processing 63 2.55e-01 -8.30e-02 4.66e-01
Sensory perception of taste 22 5.01e-01 8.30e-02 6.78e-01
Diseases of mitotic cell cycle 38 3.77e-01 -8.29e-02 5.77e-01
FCERI mediated NF-kB activation 130 1.03e-01 -8.28e-02 2.71e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 3.78e-01 -8.26e-02 5.77e-01
Nucleosome assembly 38 3.78e-01 -8.26e-02 5.77e-01
Developmental Biology 924 2.21e-05 -8.23e-02 6.66e-04
Hemostasis 558 9.10e-04 -8.21e-02 1.13e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 3.03e-01 -8.19e-02 5.10e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 3.03e-01 -8.19e-02 5.10e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 3.03e-01 -8.19e-02 5.10e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 3.03e-01 -8.19e-02 5.10e-01
Signaling by NOTCH1 in Cancer 53 3.03e-01 -8.19e-02 5.10e-01
Presynaptic depolarization and calcium channel opening 8 6.89e-01 8.18e-02 8.15e-01
SUMO E3 ligases SUMOylate target proteins 161 7.35e-02 -8.17e-02 2.17e-01
Gene expression (Transcription) 1404 2.89e-07 -8.17e-02 2.14e-05
SLC transporter disorders 76 2.18e-01 -8.17e-02 4.30e-01
GP1b-IX-V activation signalling 11 6.40e-01 8.15e-02 7.84e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 4.99e-01 -8.14e-02 6.77e-01
Cellular response to heat stress 94 1.74e-01 -8.11e-02 3.74e-01
WNT mediated activation of DVL 8 6.91e-01 8.11e-02 8.16e-01
Glycosaminoglycan metabolism 98 1.65e-01 -8.11e-02 3.61e-01
Cardiogenesis 14 6.01e-01 -8.08e-02 7.53e-01
HS-GAG biosynthesis 21 5.23e-01 -8.06e-02 6.96e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 4.62e-01 -8.04e-02 6.54e-01
Estrogen-dependent gene expression 96 1.74e-01 -8.04e-02 3.74e-01
RUNX2 regulates osteoblast differentiation 19 5.45e-01 -8.03e-02 7.13e-01
Activation of C3 and C5 7 7.13e-01 8.03e-02 8.32e-01
Nucleotide salvage 21 5.25e-01 -8.02e-02 6.96e-01
Interleukin-18 signaling 6 7.34e-01 8.01e-02 8.45e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 3.34e-01 -7.97e-02 5.43e-01
Cytosolic sensors of pathogen-associated DNA 63 2.74e-01 -7.97e-02 4.85e-01
Pre-NOTCH Processing in Golgi 18 5.59e-01 -7.96e-02 7.21e-01
Synthesis of Ketone Bodies 6 7.36e-01 -7.96e-02 8.45e-01
cGMP effects 12 6.35e-01 7.92e-02 7.81e-01
Urea cycle 7 7.17e-01 7.91e-02 8.35e-01
RUNX2 regulates bone development 24 5.02e-01 -7.91e-02 6.80e-01
Defective B3GAT3 causes JDSSDHD 12 6.36e-01 -7.88e-02 7.82e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 6.83e-01 7.85e-02 8.12e-01
PIWI-interacting RNA (piRNA) biogenesis 23 5.15e-01 -7.84e-02 6.89e-01
RHOT1 GTPase cycle 5 7.62e-01 -7.83e-02 8.62e-01
Post NMDA receptor activation events 64 2.80e-01 -7.81e-02 4.90e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.99e-01 -7.81e-02 6.77e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 4.76e-01 -7.79e-02 6.64e-01
Sensory processing of sound by outer hair cells of the cochlea 41 3.88e-01 7.78e-02 5.88e-01
Phenylalanine metabolism 5 7.64e-01 7.76e-02 8.64e-01
Signaling by ERBB2 TMD/JMD mutants 17 5.80e-01 -7.76e-02 7.36e-01
SHC-mediated cascade:FGFR4 11 6.57e-01 -7.74e-02 7.94e-01
Signaling by ERBB2 ECD mutants 15 6.04e-01 -7.73e-02 7.55e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 2.18e-01 -7.72e-02 4.30e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 2.18e-01 -7.72e-02 4.30e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 2.18e-01 -7.72e-02 4.30e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 3.57e-01 7.68e-02 5.59e-01
Bicarbonate transporters 9 6.90e-01 7.68e-02 8.16e-01
MET activates RAS signaling 10 6.75e-01 -7.65e-02 8.08e-01
G0 and Early G1 27 4.92e-01 7.64e-02 6.73e-01
Keratinization 38 4.16e-01 -7.63e-02 6.13e-01
Termination of translesion DNA synthesis 32 4.59e-01 -7.57e-02 6.51e-01
SARS-CoV-2 modulates host translation machinery 49 3.59e-01 -7.57e-02 5.60e-01
G1/S-Specific Transcription 29 4.81e-01 7.56e-02 6.66e-01
Mitotic Prometaphase 193 7.10e-02 -7.54e-02 2.13e-01
Phospholipase C-mediated cascade; FGFR3 5 7.71e-01 7.52e-02 8.71e-01
NRAGE signals death through JNK 52 3.48e-01 7.52e-02 5.52e-01
Aggrephagy 34 4.49e-01 -7.50e-02 6.43e-01
RNA Polymerase II Transcription 1197 1.26e-05 -7.50e-02 4.25e-04
Fibronectin matrix formation 6 7.51e-01 -7.49e-02 8.54e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 3.37e-01 -7.48e-02 5.44e-01
Anchoring fibril formation 8 7.15e-01 -7.46e-02 8.33e-01
FGFR3 ligand binding and activation 5 7.73e-01 7.44e-02 8.72e-01
FGFR3c ligand binding and activation 5 7.73e-01 7.44e-02 8.72e-01
Glycogen breakdown (glycogenolysis) 13 6.42e-01 -7.44e-02 7.85e-01
DNA Double Strand Break Response 47 3.78e-01 -7.44e-02 5.77e-01
EML4 and NUDC in mitotic spindle formation 107 1.84e-01 -7.43e-02 3.89e-01
RHOC GTPase cycle 71 2.83e-01 -7.37e-02 4.94e-01
N-Glycan antennae elongation 13 6.46e-01 7.35e-02 7.88e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 3.99e-01 -7.35e-02 5.98e-01
PPARA activates gene expression 105 1.94e-01 -7.33e-02 4.01e-01
TBC/RABGAPs 45 3.96e-01 -7.32e-02 5.95e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 7.37e-01 -7.32e-02 8.45e-01
Signaling by NOTCH1 66 3.05e-01 -7.30e-02 5.12e-01
TGFBR3 expression 20 5.72e-01 7.29e-02 7.31e-01
HCMV Early Events 84 2.50e-01 -7.27e-02 4.62e-01
Endogenous sterols 17 6.04e-01 -7.26e-02 7.55e-01
PI-3K cascade:FGFR2 13 6.51e-01 -7.26e-02 7.90e-01
Integration of energy metabolism 88 2.41e-01 -7.24e-02 4.55e-01
G2 Phase 5 7.80e-01 -7.23e-02 8.77e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 5.25e-01 -7.20e-02 6.96e-01
RND3 GTPase cycle 35 4.62e-01 -7.19e-02 6.54e-01
SUMOylation of DNA replication proteins 46 3.99e-01 -7.19e-02 5.98e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 4.82e-01 -7.18e-02 6.67e-01
CD28 dependent PI3K/Akt signaling 22 5.60e-01 -7.17e-02 7.22e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 6.54e-01 -7.17e-02 7.93e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 4.02e-01 -7.14e-02 5.99e-01
Fcgamma receptor (FCGR) dependent phagocytosis 148 1.36e-01 -7.10e-02 3.18e-01
RNA Polymerase III Abortive And Retractive Initiation 40 4.37e-01 -7.10e-02 6.34e-01
RNA Polymerase III Transcription 40 4.37e-01 -7.10e-02 6.34e-01
RSV-host interactions 78 2.79e-01 -7.09e-02 4.89e-01
Signal Transduction 2051 1.19e-07 -7.09e-02 9.20e-06
CRMPs in Sema3A signaling 14 6.46e-01 -7.08e-02 7.88e-01
Neurexins and neuroligins 38 4.51e-01 7.07e-02 6.43e-01
Regulation of lipid metabolism by PPARalpha 107 2.08e-01 -7.04e-02 4.19e-01
Lagging Strand Synthesis 20 5.86e-01 7.04e-02 7.41e-01
ERBB2 Activates PTK6 Signaling 8 7.30e-01 -7.04e-02 8.44e-01
Vitamin D (calciferol) metabolism 11 6.87e-01 -7.02e-02 8.14e-01
Gluconeogenesis 19 5.96e-01 -7.02e-02 7.49e-01
Neurotransmitter release cycle 35 4.73e-01 7.01e-02 6.62e-01
The phototransduction cascade 27 5.29e-01 7.01e-02 6.99e-01
Cell Cycle 611 3.22e-03 -6.98e-02 2.79e-02
Deactivation of the beta-catenin transactivating complex 36 4.70e-01 6.96e-02 6.59e-01
Activation of gene expression by SREBF (SREBP) 42 4.36e-01 -6.95e-02 6.33e-01
MAPK family signaling cascades 263 5.39e-02 -6.91e-02 1.78e-01
Generic Transcription Pathway 1079 1.34e-04 -6.88e-02 2.54e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 5.36e-01 -6.88e-02 7.05e-01
Eicosanoids 8 7.36e-01 6.88e-02 8.45e-01
PLC beta mediated events 40 4.52e-01 -6.87e-02 6.45e-01
Resolution of D-Loop Structures 35 4.83e-01 -6.86e-02 6.68e-01
Germ layer formation at gastrulation 9 7.23e-01 6.82e-02 8.38e-01
Activation of kainate receptors upon glutamate binding 26 5.47e-01 -6.82e-02 7.14e-01
Interleukin-4 and Interleukin-13 signaling 92 2.59e-01 6.81e-02 4.68e-01
Beta-oxidation of very long chain fatty acids 11 6.96e-01 6.81e-02 8.19e-01
p75 NTR receptor-mediated signalling 89 2.68e-01 -6.80e-02 4.80e-01
MECP2 regulates neuronal receptors and channels 14 6.61e-01 -6.77e-02 7.97e-01
IGF1R signaling cascade 37 4.77e-01 -6.76e-02 6.64e-01
Paracetamol ADME 19 6.11e-01 -6.74e-02 7.61e-01
Regulation of Expression and Function of Type II Classical Cadherins 24 5.68e-01 6.74e-02 7.29e-01
Regulation of Homotypic Cell-Cell Adhesion 24 5.68e-01 6.74e-02 7.29e-01
Transport of RCbl within the body 8 7.43e-01 6.70e-02 8.48e-01
RNA Polymerase III Transcription Initiation 36 4.87e-01 -6.69e-02 6.70e-01
Factors involved in megakaryocyte development and platelet production 129 1.91e-01 6.67e-02 3.96e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 5.65e-01 -6.65e-02 7.27e-01
TNFR2 non-canonical NF-kB pathway 84 2.94e-01 -6.62e-02 5.04e-01
TNF signaling 56 3.93e-01 -6.60e-02 5.93e-01
Assembly Of The HIV Virion 15 6.58e-01 -6.60e-02 7.94e-01
Regulation of innate immune responses to cytosolic DNA 14 6.70e-01 6.57e-02 8.03e-01
RAS processing 23 5.86e-01 -6.57e-02 7.41e-01
RAC1 GTPase cycle 172 1.38e-01 -6.55e-02 3.21e-01
DNA methylation 18 6.31e-01 -6.54e-02 7.78e-01
IRS-related events triggered by IGF1R 36 4.98e-01 -6.52e-02 6.77e-01
Cell Cycle, Mitotic 488 1.37e-02 -6.52e-02 7.67e-02
Transcriptional regulation of pluripotent stem cells 19 6.25e-01 6.49e-02 7.73e-01
HDL assembly 6 7.86e-01 -6.42e-02 8.82e-01
NCAM1 interactions 26 5.72e-01 -6.41e-02 7.31e-01
Signaling by NTRK3 (TRKC) 15 6.68e-01 6.40e-02 8.03e-01
DNA Double-Strand Break Repair 137 1.96e-01 -6.39e-02 4.03e-01
Synthesis of PIPs at the ER membrane 5 8.05e-01 -6.38e-02 8.95e-01
Interleukin-37 signaling 19 6.31e-01 -6.37e-02 7.78e-01
Transport of small molecules 556 1.05e-02 -6.35e-02 6.31e-02
Mitotic G2-G2/M phases 179 1.43e-01 -6.35e-02 3.28e-01
Processive synthesis on the C-strand of the telomere 19 6.32e-01 6.34e-02 7.78e-01
Degradation of the extracellular matrix 96 2.85e-01 -6.31e-02 4.95e-01
Death Receptor Signaling 145 1.90e-01 -6.31e-02 3.96e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 6.83e-01 -6.30e-02 8.12e-01
Cell surface interactions at the vascular wall 173 1.53e-01 -6.30e-02 3.40e-01
Sphingolipid catabolism 11 7.18e-01 -6.29e-02 8.36e-01
Mitochondrial unfolded protein response (UPRmt) 17 6.54e-01 6.29e-02 7.93e-01
Mitochondrial iron-sulfur cluster biogenesis 13 6.95e-01 6.28e-02 8.19e-01
Interleukin-2 family signaling 38 5.05e-01 6.24e-02 6.82e-01
G2/M Transition 177 1.55e-01 -6.20e-02 3.44e-01
Nicotinamide salvaging 16 6.68e-01 -6.19e-02 8.03e-01
ChREBP activates metabolic gene expression 7 7.77e-01 6.17e-02 8.75e-01
Resolution of Abasic Sites (AP sites) 38 5.11e-01 6.17e-02 6.86e-01
Intrinsic Pathway of Fibrin Clot Formation 15 6.80e-01 6.15e-02 8.12e-01
Nuclear Receptor transcription pathway 38 5.14e-01 -6.12e-02 6.89e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 6.04e-01 -6.11e-02 7.55e-01
Nicotinate metabolism 27 5.84e-01 -6.09e-02 7.40e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 7.27e-01 -6.09e-02 8.41e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 7.97e-01 6.07e-02 8.91e-01
Cholesterol biosynthesis 26 5.92e-01 6.07e-02 7.47e-01
Ca-dependent events 30 5.66e-01 -6.05e-02 7.28e-01
STING mediated induction of host immune responses 15 6.85e-01 -6.05e-02 8.12e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 7.98e-01 6.04e-02 8.92e-01
Signaling by FGFR2 in disease 33 5.50e-01 -6.01e-02 7.17e-01
O-linked glycosylation of mucins 47 4.76e-01 -6.00e-02 6.64e-01
Pre-NOTCH Transcription and Translation 47 4.78e-01 -5.98e-02 6.64e-01
Signaling by NOTCH2 33 5.53e-01 -5.97e-02 7.18e-01
Transcriptional Regulation by MECP2 49 4.72e-01 -5.93e-02 6.61e-01
Zinc influx into cells by the SLC39 gene family 9 7.58e-01 5.93e-02 8.59e-01
Glutathione synthesis and recycling 10 7.46e-01 -5.93e-02 8.51e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 7.22e-01 5.93e-02 8.38e-01
Transport of connexons to the plasma membrane 12 7.22e-01 5.93e-02 8.38e-01
Activation of Matrix Metalloproteinases 22 6.30e-01 5.93e-02 7.78e-01
Regulation of actin dynamics for phagocytic cup formation 124 2.56e-01 -5.91e-02 4.66e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 5.75e-01 -5.91e-02 7.34e-01
Uptake and actions of bacterial toxins 27 5.96e-01 -5.90e-02 7.49e-01
Carnitine shuttle 12 7.28e-01 -5.80e-02 8.42e-01
Interferon gamma signaling 90 3.42e-01 -5.80e-02 5.45e-01
Receptor Mediated Mitophagy 11 7.42e-01 -5.74e-02 8.48e-01
TRAF6 mediated IRF7 activation 15 7.03e-01 5.70e-02 8.23e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 6.22e-01 -5.69e-02 7.71e-01
Metabolism of vitamins and cofactors 167 2.06e-01 -5.67e-02 4.16e-01
Arachidonate metabolism 47 5.03e-01 -5.65e-02 6.80e-01
Defective C1GALT1C1 causes TNPS 10 7.57e-01 5.65e-02 8.58e-01
Interleukin-15 signaling 14 7.16e-01 5.61e-02 8.35e-01
GDP-fucose biosynthesis 6 8.13e-01 -5.59e-02 9.00e-01
Semaphorin interactions 57 4.67e-01 -5.57e-02 6.58e-01
Vitamin B5 (pantothenate) metabolism 20 6.70e-01 5.51e-02 8.03e-01
Expression and translocation of olfactory receptors 52 4.93e-01 5.49e-02 6.73e-01
Regulation of FZD by ubiquitination 16 7.04e-01 -5.48e-02 8.23e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 8.02e-01 -5.48e-02 8.93e-01
Phase 4 - resting membrane potential 9 7.76e-01 -5.48e-02 8.74e-01
RND1 GTPase cycle 36 5.70e-01 -5.47e-02 7.30e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 3.35e-01 -5.47e-02 5.44e-01
Regulation of CDH11 gene transcription 5 8.32e-01 -5.47e-02 9.11e-01
Sensory Perception 194 1.91e-01 5.45e-02 3.96e-01
Antimicrobial peptides 34 5.85e-01 5.41e-02 7.41e-01
Scavenging of heme from plasma 71 4.33e-01 5.38e-02 6.30e-01
Non-integrin membrane-ECM interactions 49 5.15e-01 -5.38e-02 6.89e-01
Neurotransmitter receptors and postsynaptic signal transmission 139 2.74e-01 -5.37e-02 4.85e-01
Hyaluronan metabolism 15 7.20e-01 -5.35e-02 8.37e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 6.80e-01 5.33e-02 8.12e-01
Trafficking of AMPA receptors 20 6.80e-01 5.33e-02 8.12e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 6.32e-01 5.32e-02 7.78e-01
Epigenetic regulation of gene expression 264 1.38e-01 -5.30e-02 3.21e-01
Bile acid and bile salt metabolism 30 6.17e-01 -5.28e-02 7.66e-01
rRNA processing in the mitochondrion 24 6.56e-01 -5.25e-02 7.94e-01
G alpha (i) signalling events 196 2.06e-01 -5.24e-02 4.16e-01
Metabolism of Angiotensinogen to Angiotensins 12 7.55e-01 -5.21e-02 8.58e-01
Metabolism of steroid hormones 21 6.81e-01 -5.19e-02 8.12e-01
Activation of AMPK downstream of NMDARs 20 6.88e-01 -5.19e-02 8.15e-01
Nephrin family interactions 20 6.88e-01 5.18e-02 8.15e-01
Peptide ligand-binding receptors 102 3.67e-01 5.17e-02 5.67e-01
Membrane binding and targetting of GAG proteins 13 7.49e-01 -5.13e-02 8.53e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 7.49e-01 -5.13e-02 8.53e-01
Telomere Maintenance 78 4.33e-01 -5.13e-02 6.30e-01
tRNA Aminoacylation 42 5.65e-01 -5.13e-02 7.27e-01
Glycine degradation 7 8.14e-01 -5.13e-02 9.00e-01
Arachidonate production from DAG 5 8.43e-01 -5.11e-02 9.18e-01
Interferon alpha/beta signaling 64 4.85e-01 -5.04e-02 6.70e-01
CDC42 GTPase cycle 140 3.03e-01 -5.04e-02 5.10e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 188 2.34e-01 5.03e-02 4.49e-01
MITF-M-dependent gene expression 84 4.28e-01 -5.00e-02 6.25e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 8.47e-01 -4.99e-02 9.19e-01
Relaxin receptors 5 8.47e-01 4.98e-02 9.19e-01
Synthesis of 5-eicosatetraenoic acids 7 8.20e-01 -4.97e-02 9.02e-01
Collagen degradation 42 5.77e-01 -4.97e-02 7.34e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 3.53e-01 -4.97e-02 5.55e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 6.67e-01 -4.97e-02 8.03e-01
Role of phospholipids in phagocytosis 89 4.18e-01 4.96e-02 6.15e-01
FOXO-mediated transcription of cell death genes 16 7.32e-01 4.95e-02 8.44e-01
GPCR ligand binding 245 1.82e-01 4.95e-02 3.86e-01
Anchoring of the basal body to the plasma membrane 97 4.01e-01 -4.93e-02 5.99e-01
Regulation of gene expression in beta cells 8 8.09e-01 4.93e-02 8.98e-01
DAP12 interactions 39 5.95e-01 -4.92e-02 7.49e-01
Other semaphorin interactions 16 7.34e-01 -4.90e-02 8.45e-01
Sialic acid metabolism 28 6.56e-01 -4.87e-02 7.94e-01
Regulation of CDH19 Expression and Function 6 8.36e-01 -4.87e-02 9.14e-01
Basigin interactions 21 7.01e-01 -4.83e-02 8.23e-01
Leading Strand Synthesis 14 7.56e-01 4.80e-02 8.58e-01
Polymerase switching 14 7.56e-01 4.80e-02 8.58e-01
Trafficking of GluR2-containing AMPA receptors 11 7.84e-01 -4.77e-02 8.81e-01
Interleukin-1 processing 8 8.16e-01 4.75e-02 9.01e-01
SHC-related events triggered by IGF1R 7 8.29e-01 -4.71e-02 9.09e-01
Synthesis of GDP-mannose 6 8.42e-01 4.70e-02 9.17e-01
Collagen formation 64 5.18e-01 -4.68e-02 6.92e-01
Plasma lipoprotein clearance 32 6.51e-01 -4.62e-02 7.90e-01
Base Excision Repair 57 5.47e-01 -4.61e-02 7.14e-01
Evasion by RSV of host interferon responses 20 7.22e-01 -4.60e-02 8.38e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 8.13e-01 4.55e-02 9.00e-01
MAPK1/MAPK3 signaling 231 2.36e-01 -4.53e-02 4.51e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 7.47e-01 4.53e-02 8.51e-01
Downregulation of ERBB2:ERBB3 signaling 12 7.86e-01 -4.52e-02 8.82e-01
Gap junction trafficking 28 6.79e-01 -4.52e-02 8.12e-01
TCF dependent signaling in response to WNT 152 3.36e-01 -4.52e-02 5.44e-01
Integrin cell surface interactions 65 5.30e-01 -4.51e-02 6.99e-01
Costimulation by the CD28 family 74 5.05e-01 -4.49e-02 6.82e-01
Regulation of insulin secretion 63 5.42e-01 -4.44e-02 7.11e-01
Transport of bile salts and organic acids, metal ions and amine compounds 53 5.78e-01 -4.42e-02 7.34e-01
Telomere C-strand (Lagging Strand) Synthesis 34 6.56e-01 4.42e-02 7.94e-01
RHOU GTPase cycle 40 6.30e-01 -4.40e-02 7.78e-01
Nef Mediated CD8 Down-regulation 7 8.41e-01 4.39e-02 9.17e-01
Signaling by Retinoic Acid 29 6.84e-01 -4.37e-02 8.12e-01
O-linked glycosylation 85 4.90e-01 4.33e-02 6.71e-01
PI3K/AKT Signaling in Cancer 84 4.93e-01 -4.32e-02 6.73e-01
CD209 (DC-SIGN) signaling 20 7.39e-01 -4.31e-02 8.45e-01
Collagen chain trimerization 27 6.98e-01 4.31e-02 8.21e-01
ECM proteoglycans 47 6.09e-01 -4.31e-02 7.60e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.88e-01 -4.30e-02 6.70e-01
RUNX1 regulates expression of components of tight junctions 5 8.69e-01 4.25e-02 9.30e-01
DAP12 signaling 28 6.97e-01 -4.25e-02 8.20e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 8.16e-01 -4.24e-02 9.01e-01
Phospholipase C-mediated cascade: FGFR1 8 8.36e-01 4.24e-02 9.13e-01
EPHA-mediated growth cone collapse 21 7.38e-01 -4.22e-02 8.45e-01
NOTCH2 intracellular domain regulates transcription 11 8.09e-01 -4.21e-02 8.98e-01
Signaling by the B Cell Receptor (BCR) 151 3.73e-01 -4.20e-02 5.72e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 8.02e-01 -4.18e-02 8.93e-01
TRP channels 22 7.36e-01 4.15e-02 8.45e-01
Platelet calcium homeostasis 22 7.36e-01 4.15e-02 8.45e-01
Receptor-type tyrosine-protein phosphatases 11 8.13e-01 -4.12e-02 9.00e-01
Suppression of apoptosis 7 8.52e-01 4.08e-02 9.22e-01
Sensory processing of sound by inner hair cells of the cochlea 54 6.07e-01 4.05e-02 7.56e-01
Metabolism of water-soluble vitamins and cofactors 116 4.53e-01 -4.04e-02 6.45e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 8.02e-01 -4.02e-02 8.93e-01
mRNA Splicing - Minor Pathway 50 6.24e-01 -4.01e-02 7.73e-01
Extracellular matrix organization 219 3.07e-01 -4.00e-02 5.14e-01
CDC6 association with the ORC:origin complex 8 8.45e-01 -3.99e-02 9.18e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 6.73e-01 -3.96e-02 8.05e-01
HDACs deacetylate histones 45 6.47e-01 -3.94e-02 7.89e-01
Release of apoptotic factors from the mitochondria 6 8.68e-01 -3.93e-02 9.29e-01
FCERI mediated Ca+2 mobilization 93 5.13e-01 3.92e-02 6.88e-01
AKT phosphorylates targets in the cytosol 14 8.00e-01 -3.92e-02 8.93e-01
FCGR activation 77 5.53e-01 3.91e-02 7.18e-01
Regulation of PTEN gene transcription 59 6.05e-01 -3.89e-02 7.55e-01
Chromosome Maintenance 103 4.97e-01 -3.87e-02 6.77e-01
Cell death signalling via NRAGE, NRIF and NADE 69 5.81e-01 -3.84e-02 7.37e-01
Laminin interactions 26 7.35e-01 3.83e-02 8.45e-01
VEGF binds to VEGFR leading to receptor dimerization 5 8.82e-01 3.83e-02 9.37e-01
VEGF ligand-receptor interactions 5 8.82e-01 3.83e-02 9.37e-01
Visual phototransduction 61 6.05e-01 3.83e-02 7.55e-01
Class A/1 (Rhodopsin-like receptors) 177 3.82e-01 3.81e-02 5.82e-01
Signaling by ALK fusions and activated point mutants 89 5.35e-01 -3.81e-02 7.04e-01
Signaling by ALK in cancer 89 5.35e-01 -3.81e-02 7.04e-01
RHO GTPases activate KTN1 11 8.27e-01 3.81e-02 9.08e-01
Amino acid transport across the plasma membrane 25 7.44e-01 -3.78e-02 8.49e-01
Interleukin-10 signaling 39 6.85e-01 3.76e-02 8.12e-01
RHOA GTPase cycle 138 4.47e-01 -3.75e-02 6.43e-01
Assembly and cell surface presentation of NMDA receptors 34 7.06e-01 3.74e-02 8.24e-01
Homology Directed Repair 110 4.98e-01 -3.74e-02 6.77e-01
FCGR3A-mediated IL10 synthesis 100 5.27e-01 3.66e-02 6.98e-01
FRS-mediated FGFR2 signaling 15 8.07e-01 3.63e-02 8.97e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 7.52e-01 3.58e-02 8.55e-01
TNFR1-mediated ceramide production 6 8.80e-01 -3.56e-02 9.36e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 8.17e-01 3.56e-02 9.01e-01
PKMTs methylate histone lysines 43 6.92e-01 3.49e-02 8.16e-01
Anti-inflammatory response favouring Leishmania parasite infection 133 4.87e-01 -3.49e-02 6.70e-01
Leishmania parasite growth and survival 133 4.87e-01 -3.49e-02 6.70e-01
Regulation of TP53 Activity through Association with Co-factors 13 8.28e-01 3.47e-02 9.09e-01
FGFRL1 modulation of FGFR1 signaling 7 8.74e-01 3.46e-02 9.31e-01
Diseases associated with glycosylation precursor biosynthesis 15 8.19e-01 -3.41e-02 9.02e-01
HSF1 activation 26 7.64e-01 3.41e-02 8.64e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 7.31e-01 -3.36e-02 8.44e-01
Gap junction trafficking and regulation 30 7.52e-01 -3.33e-02 8.55e-01
Olfactory Signaling Pathway 57 6.67e-01 3.30e-02 8.03e-01
Regulation of Complement cascade 97 5.76e-01 3.29e-02 7.34e-01
Netrin-1 signaling 35 7.37e-01 3.28e-02 8.45e-01
Sensory processing of sound 58 6.69e-01 3.25e-02 8.03e-01
Tight junction interactions 17 8.17e-01 3.24e-02 9.01e-01
DNA Damage Reversal 8 8.74e-01 -3.24e-02 9.31e-01
Signaling by RNF43 mutants 7 8.82e-01 3.24e-02 9.37e-01
RAF/MAP kinase cascade 225 4.03e-01 -3.23e-02 6.01e-01
Activation of RAS in B cells 5 9.00e-01 3.23e-02 9.49e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 51 6.91e-01 3.22e-02 8.16e-01
Sodium/Proton exchangers 7 8.83e-01 -3.21e-02 9.37e-01
Kidney development 17 8.22e-01 3.16e-02 9.03e-01
Diseases of glycosylation 110 5.72e-01 -3.12e-02 7.31e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 8.88e-01 3.09e-02 9.41e-01
Carboxyterminal post-translational modifications of tubulin 34 7.56e-01 3.08e-02 8.58e-01
Nef and signal transduction 8 8.82e-01 3.04e-02 9.37e-01
ZBP1(DAI) mediated induction of type I IFNs 20 8.14e-01 3.04e-02 9.00e-01
Aspirin ADME 15 8.40e-01 3.01e-02 9.16e-01
Netrin mediated repulsion signals 5 9.07e-01 3.00e-02 9.50e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 9.08e-01 -3.00e-02 9.50e-01
CASP8 activity is inhibited 11 8.64e-01 -2.98e-02 9.27e-01
Dimerization of procaspase-8 11 8.64e-01 -2.98e-02 9.27e-01
Regulation by c-FLIP 11 8.64e-01 -2.98e-02 9.27e-01
Recruitment of NuMA to mitotic centrosomes 88 6.29e-01 -2.98e-02 7.78e-01
Glycosphingolipid biosynthesis 15 8.44e-01 -2.93e-02 9.18e-01
L1CAM interactions 101 6.15e-01 -2.89e-02 7.65e-01
Regulation of CDH11 Expression and Function 22 8.17e-01 2.85e-02 9.01e-01
Cardiac conduction 89 6.42e-01 2.85e-02 7.85e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 8.55e-01 -2.82e-02 9.23e-01
Transmission across Chemical Synapses 183 5.12e-01 -2.81e-02 6.87e-01
Activation of the pre-replicative complex 32 7.84e-01 -2.80e-02 8.81e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 8.06e-01 2.79e-02 8.96e-01
Lewis blood group biosynthesis 13 8.62e-01 -2.79e-02 9.27e-01
Transcriptional regulation by RUNX1 170 5.33e-01 -2.77e-02 7.03e-01
Biosynthesis of EPA-derived SPMs 6 9.07e-01 2.77e-02 9.50e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 6.51e-01 -2.76e-02 7.90e-01
Striated Muscle Contraction 27 8.04e-01 2.75e-02 8.95e-01
Metabolism of fat-soluble vitamins 28 8.02e-01 -2.74e-02 8.93e-01
The canonical retinoid cycle in rods (twilight vision) 9 8.88e-01 -2.70e-02 9.42e-01
Defects in cobalamin (B12) metabolism 13 8.66e-01 -2.69e-02 9.29e-01
Protein-protein interactions at synapses 58 7.23e-01 2.69e-02 8.38e-01
Initial triggering of complement 80 6.83e-01 2.64e-02 8.12e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 7.22e-01 -2.64e-02 8.38e-01
Chromatin modifying enzymes 214 5.08e-01 -2.63e-02 6.83e-01
Chromatin organization 214 5.08e-01 -2.63e-02 6.83e-01
Notch-HLH transcription pathway 28 8.10e-01 2.62e-02 8.99e-01
tRNA modification in the nucleus and cytosol 43 7.69e-01 -2.59e-02 8.69e-01
Negative regulation of FLT3 15 8.63e-01 -2.58e-02 9.27e-01
RUNX3 regulates NOTCH signaling 14 8.69e-01 -2.55e-02 9.30e-01
Activation of G protein gated Potassium channels 19 8.50e-01 -2.51e-02 9.20e-01
G protein gated Potassium channels 19 8.50e-01 -2.51e-02 9.20e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 8.50e-01 -2.51e-02 9.20e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 8.54e-01 2.50e-02 9.23e-01
RORA activates gene expression 18 8.56e-01 -2.47e-02 9.24e-01
G alpha (12/13) signalling events 68 7.27e-01 2.45e-02 8.41e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.74e-01 -2.44e-02 9.31e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.74e-01 -2.44e-02 9.31e-01
Growth hormone receptor signaling 20 8.53e-01 -2.39e-02 9.23e-01
Classical antibody-mediated complement activation 70 7.33e-01 2.36e-02 8.44e-01
Complement cascade 101 6.83e-01 2.35e-02 8.12e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 8.60e-01 -2.34e-02 9.27e-01
Amine ligand-binding receptors 10 9.02e-01 2.25e-02 9.50e-01
CaMK IV-mediated phosphorylation of CREB 9 9.08e-01 -2.24e-02 9.50e-01
Formation of Fibrin Clot (Clotting Cascade) 26 8.44e-01 -2.23e-02 9.18e-01
Activation of GABAB receptors 30 8.34e-01 -2.22e-02 9.12e-01
GABA B receptor activation 30 8.34e-01 -2.22e-02 9.12e-01
SLC-mediated transmembrane transport 174 6.19e-01 -2.19e-02 7.68e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.63e-01 -2.18e-02 9.27e-01
Molecules associated with elastic fibres 26 8.50e-01 2.15e-02 9.20e-01
FGFR1 ligand binding and activation 10 9.07e-01 2.14e-02 9.50e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 9.02e-01 2.14e-02 9.50e-01
Purine salvage 12 8.99e-01 -2.13e-02 9.48e-01
Cytochrome P450 - arranged by substrate type 39 8.19e-01 2.12e-02 9.01e-01
Regulation of MITF-M-dependent genes involved in pigmentation 38 8.21e-01 -2.12e-02 9.03e-01
PKA activation in glucagon signalling 14 8.91e-01 -2.11e-02 9.42e-01
Assembly of collagen fibrils and other multimeric structures 42 8.16e-01 2.07e-02 9.01e-01
Platelet Aggregation (Plug Formation) 29 8.48e-01 -2.06e-02 9.20e-01
Cell-cell junction organization 57 7.89e-01 2.05e-02 8.84e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 8.71e-01 -2.05e-02 9.31e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 9.38e-01 2.02e-02 9.69e-01
Adherens junctions interactions 38 8.29e-01 2.02e-02 9.09e-01
G alpha (s) signalling events 96 7.36e-01 -1.99e-02 8.45e-01
Biosynthesis of Lipoxins (LX) 6 9.35e-01 1.93e-02 9.69e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 9.31e-01 1.89e-02 9.66e-01
Plasma lipoprotein remodeling 18 8.90e-01 1.89e-02 9.42e-01
Specification of primordial germ cells 6 9.36e-01 -1.88e-02 9.69e-01
RIP-mediated NFkB activation via ZBP1 17 8.93e-01 1.88e-02 9.43e-01
RA biosynthesis pathway 13 9.07e-01 1.87e-02 9.50e-01
Loss of Nlp from mitotic centrosomes 69 7.90e-01 -1.86e-02 8.84e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 7.90e-01 -1.86e-02 8.84e-01
Centrosome maturation 81 7.74e-01 -1.85e-02 8.72e-01
Recruitment of mitotic centrosome proteins and complexes 81 7.74e-01 -1.85e-02 8.72e-01
G alpha (q) signalling events 139 7.09e-01 -1.84e-02 8.27e-01
Muscle contraction 145 7.03e-01 -1.83e-02 8.23e-01
Keratan sulfate/keratin metabolism 28 8.67e-01 1.83e-02 9.29e-01
Potential therapeutics for SARS 150 6.99e-01 1.83e-02 8.21e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.00e-01 1.81e-02 9.49e-01
Defective LFNG causes SCDO3 5 9.44e-01 1.81e-02 9.72e-01
Cell junction organization 78 7.84e-01 1.79e-02 8.81e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 9.08e-01 -1.78e-02 9.50e-01
Metabolism of amine-derived hormones 10 9.24e-01 1.74e-02 9.62e-01
Adenylate cyclase inhibitory pathway 11 9.22e-01 -1.70e-02 9.62e-01
GPCR downstream signalling 399 5.61e-01 -1.70e-02 7.23e-01
Regulation of TNFR1 signaling 47 8.41e-01 -1.69e-02 9.17e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.43e-01 -1.69e-02 9.72e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.43e-01 -1.69e-02 9.72e-01
PKA activation 15 9.12e-01 -1.66e-02 9.53e-01
Mitochondrial Uncoupling 6 9.46e-01 1.61e-02 9.73e-01
Regulation of endogenous retroelements 93 7.89e-01 1.60e-02 8.84e-01
Role of LAT2/NTAL/LAB on calcium mobilization 78 8.10e-01 1.58e-02 8.98e-01
Transcriptional regulation of granulopoiesis 44 8.57e-01 1.57e-02 9.25e-01
GABA receptor activation 36 8.71e-01 -1.56e-02 9.31e-01
IL-6-type cytokine receptor ligand interactions 13 9.23e-01 -1.56e-02 9.62e-01
Mitochondrial tRNA aminoacylation 21 9.02e-01 -1.56e-02 9.50e-01
Glucagon-type ligand receptors 20 9.06e-01 1.53e-02 9.50e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 8.62e-01 -1.52e-02 9.27e-01
Ion homeostasis 42 8.66e-01 1.51e-02 9.28e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 9.46e-01 1.49e-02 9.73e-01
Transcriptional Regulation by VENTX 39 8.75e-01 -1.45e-02 9.32e-01
Neuronal System 270 6.84e-01 1.44e-02 8.12e-01
Malate-aspartate shuttle 8 9.44e-01 -1.44e-02 9.72e-01
Formation of the Editosome 6 9.52e-01 -1.42e-02 9.77e-01
mRNA Editing: C to U Conversion 6 9.52e-01 -1.42e-02 9.77e-01
Cell-Cell communication 110 7.98e-01 -1.41e-02 8.92e-01
Acetylcholine regulates insulin secretion 9 9.42e-01 -1.40e-02 9.72e-01
Sema3A PAK dependent Axon repulsion 16 9.24e-01 1.38e-02 9.62e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 9.37e-01 -1.37e-02 9.69e-01
RMTs methylate histone arginines 35 8.92e-01 1.33e-02 9.42e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 8.62e-01 -1.33e-02 9.27e-01
Removal of the Flap Intermediate from the C-strand 17 9.24e-01 -1.33e-02 9.62e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 8.40e-01 1.31e-02 9.16e-01
Extension of Telomeres 51 8.74e-01 1.29e-02 9.31e-01
Reversal of alkylation damage by DNA dioxygenases 7 9.53e-01 1.29e-02 9.77e-01
FCERI mediated MAPK activation 94 8.31e-01 -1.27e-02 9.10e-01
Sema4D induced cell migration and growth-cone collapse 19 9.24e-01 1.26e-02 9.62e-01
Ribavirin ADME 11 9.42e-01 -1.26e-02 9.72e-01
FGFR1c ligand binding and activation 8 9.51e-01 1.25e-02 9.77e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 9.15e-01 1.23e-02 9.56e-01
Regulation of MECP2 expression and activity 29 9.09e-01 -1.22e-02 9.51e-01
Regulation of RUNX1 Expression and Activity 18 9.30e-01 1.20e-02 9.65e-01
TNFR1-induced NF-kappa-B signaling pathway 32 9.07e-01 1.20e-02 9.50e-01
Creation of C4 and C2 activators 72 8.61e-01 1.19e-02 9.27e-01
NCAM signaling for neurite out-growth 47 8.91e-01 1.15e-02 9.42e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 9.37e-01 -1.14e-02 9.69e-01
Sema4D in semaphorin signaling 22 9.27e-01 1.13e-02 9.63e-01
TP53 Regulates Transcription of Cell Death Genes 43 9.04e-01 -1.07e-02 9.50e-01
Drug ADME 57 8.91e-01 -1.05e-02 9.42e-01
Elastic fibre formation 33 9.17e-01 1.05e-02 9.57e-01
Nectin/Necl trans heterodimerization 5 9.68e-01 -1.02e-02 9.85e-01
Assembly of active LPL and LIPC lipase complexes 10 9.56e-01 1.00e-02 9.80e-01
Alternative complement activation 5 9.69e-01 1.00e-02 9.85e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 9.35e-01 -9.85e-03 9.69e-01
RHOB GTPase cycle 64 8.93e-01 -9.69e-03 9.43e-01
HIV elongation arrest and recovery 32 9.27e-01 -9.41e-03 9.63e-01
Pausing and recovery of HIV elongation 32 9.27e-01 -9.41e-03 9.63e-01
FLT3 signaling through SRC family kinases 6 9.69e-01 -9.21e-03 9.85e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 9.53e-01 9.05e-03 9.77e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 9.48e-01 8.35e-03 9.75e-01
Pyrimidine catabolism 9 9.67e-01 -8.06e-03 9.85e-01
Signaling by LTK 10 9.66e-01 7.89e-03 9.85e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 9.53e-01 -7.88e-03 9.77e-01
Stimuli-sensing channels 80 9.04e-01 7.77e-03 9.50e-01
Formation of WDR5-containing histone-modifying complexes 42 9.32e-01 7.57e-03 9.67e-01
DAG and IP3 signaling 34 9.41e-01 -7.37e-03 9.72e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.74e-01 -7.22e-03 9.85e-01
AKT phosphorylates targets in the nucleus 10 9.71e-01 -6.72e-03 9.85e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 9.62e-01 -6.69e-03 9.83e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 9.62e-01 -6.69e-03 9.83e-01
Scavenging by Class F Receptors 5 9.80e-01 -6.58e-03 9.89e-01
Attachment and Entry 9694614 15 9.66e-01 -6.35e-03 9.85e-01
Retinoid metabolism and transport 25 9.59e-01 -5.90e-03 9.82e-01
RHO GTPases activate CIT 18 9.66e-01 -5.79e-03 9.85e-01
Mismatch Repair 15 9.73e-01 -5.05e-03 9.85e-01
Downstream signaling of activated FGFR2 20 9.69e-01 4.97e-03 9.85e-01
Miscellaneous transport and binding events 20 9.69e-01 4.97e-03 9.85e-01
Polymerase switching on the C-strand of the telomere 26 9.66e-01 4.84e-03 9.85e-01
Post-chaperonin tubulin folding pathway 18 9.72e-01 -4.77e-03 9.85e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 9.76e-01 4.73e-03 9.86e-01
FGFR2 mutant receptor activation 23 9.69e-01 4.64e-03 9.85e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 9.73e-01 -4.34e-03 9.85e-01
Biosynthesis of E-series 18(S)-resolvins 5 9.87e-01 -4.29e-03 9.91e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 9.87e-01 -3.92e-03 9.91e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.70e-01 -3.92e-03 9.85e-01
Tat-mediated HIV elongation arrest and recovery 30 9.70e-01 -3.92e-03 9.85e-01
Regulation of IFNA/IFNB signaling 12 9.82e-01 -3.84e-03 9.90e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 9.75e-01 -3.59e-03 9.86e-01
AURKA Activation by TPX2 72 9.59e-01 3.50e-03 9.82e-01
Crosslinking of collagen fibrils 13 9.84e-01 3.25e-03 9.91e-01
Killing mechanisms 10 9.87e-01 -3.03e-03 9.91e-01
WNT5:FZD7-mediated leishmania damping 10 9.87e-01 -3.03e-03 9.91e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 9.88e-01 -2.96e-03 9.92e-01
Activation of ATR in response to replication stress 37 9.78e-01 2.67e-03 9.88e-01
CaM pathway 28 9.82e-01 -2.44e-03 9.90e-01
Calmodulin induced events 28 9.82e-01 -2.44e-03 9.90e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 9.71e-01 2.16e-03 9.85e-01
RND2 GTPase cycle 36 9.85e-01 -1.87e-03 9.91e-01
Aspartate and asparagine metabolism 9 9.94e-01 1.48e-03 9.97e-01
Condensation of Prometaphase Chromosomes 11 9.94e-01 -1.30e-03 9.97e-01
Adipogenesis 95 9.85e-01 -1.11e-03 9.91e-01
Blood group systems biosynthesis 17 9.95e-01 8.80e-04 9.97e-01
Ion channel transport 141 9.89e-01 -6.52e-04 9.93e-01
Phase I - Functionalization of compounds 68 9.96e-01 -3.20e-04 9.97e-01
Signaling by GPCR 446 9.96e-01 1.44e-04 9.97e-01
Transcriptional regulation of white adipocyte differentiation 77 9.98e-01 1.26e-04 9.99e-01
Regulation of beta-cell development 22 1.00e+00 -4.16e-05 1.00e+00


Detailed Gene set reports



Phosphate bond hydrolysis by NTPDase proteins
set Phosphate bond hydrolysis by NTPDase proteins
setSize 5
pANOVA 0.00596
s.dist -0.71
p.adjustANOVA 0.0428


Top enriched genes
Top 20 genes
GeneID Gene Rank
ENTPD6 -9757
ENTPD4 -9131
ENTPD1 -8429
ENTPD5 -7178
ENTPD7 -3217

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ENTPD6 -9757
ENTPD4 -9131
ENTPD1 -8429
ENTPD5 -7178
ENTPD7 -3217


SUMO is conjugated to E1 (UBA2:SAE1)
set SUMO is conjugated to E1 (UBA2:SAE1)
setSize 5
pANOVA 0.00918
s.dist -0.673
p.adjustANOVA 0.058


Top enriched genes
Top 20 genes
GeneID Gene Rank
SUMO1 -9821
UBA2 -8248
SUMO2 -7700
SAE1 -5393
SUMO3 -4502

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUMO1 -9821
UBA2 -8248
SUMO2 -7700
SAE1 -5393
SUMO3 -4502


SUMO is proteolytically processed
set SUMO is proteolytically processed
setSize 6
pANOVA 0.00589
s.dist -0.649
p.adjustANOVA 0.0425


Top enriched genes
Top 20 genes
GeneID Gene Rank
SENP2 -9962
SUMO1 -9821
SUMO2 -7700
SENP5 -4801
SUMO3 -4502
SENP1 -4462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SENP2 -9962
SUMO1 -9821
SUMO2 -7700
SENP5 -4801
SUMO3 -4502
SENP1 -4462


Wax and plasmalogen biosynthesis
set Wax and plasmalogen biosynthesis
setSize 5
pANOVA 0.0137
s.dist -0.637
p.adjustANOVA 0.0767


Top enriched genes
Top 20 genes
GeneID Gene Rank
FAR2 -10315
AGPS -7521
GNPAT -7517
FAR1 -6406
DHRS7B -1928

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FAR2 -10315
AGPS -7521
GNPAT -7517
FAR1 -6406
DHRS7B -1928


Branched-chain ketoacid dehydrogenase kinase deficiency
set Branched-chain ketoacid dehydrogenase kinase deficiency
setSize 5
pANOVA 0.0138
s.dist -0.636
p.adjustANOVA 0.0769


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLD -9782
BCKDHB -6081
BCKDK -5985
DBT -5926
BCKDHA -5881

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLD -9782
BCKDHB -6081
BCKDK -5985
DBT -5926
BCKDHA -5881


Calcitonin-like ligand receptors
set Calcitonin-like ligand receptors
setSize 5
pANOVA 0.0161
s.dist 0.621
p.adjustANOVA 0.0843


Top enriched genes
Top 20 genes
GeneID Gene Rank
ADM2 10898
ADM 10623
CALCB 9193
RAMP1 8194
CALCRL -3844

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADM2 10898
ADM 10623
CALCB 9193
RAMP1 8194
CALCRL -3844


Activation of caspases through apoptosome-mediated cleavage
set Activation of caspases through apoptosome-mediated cleavage
setSize 6
pANOVA 0.0108
s.dist -0.601
p.adjustANOVA 0.0645


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP7 -9434
CASP3 -8463
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP7 -9434
CASP3 -8463
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699


Phosphate bond hydrolysis by NUDT proteins
set Phosphate bond hydrolysis by NUDT proteins
setSize 7
pANOVA 0.00658
s.dist -0.593
p.adjustANOVA 0.0463


Top enriched genes
Top 20 genes
GeneID Gene Rank
NUDT15 -10680
NUDT16 -10602
NUDT5 -9910
ADPRM -8488
NUDT9 -8113
NUDT1 1074
NUDT18 2888

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUDT15 -10680
NUDT16 -10602
NUDT5 -9910
ADPRM -8488
NUDT9 -8113
NUDT1 1074
NUDT18 2888


NOTCH4 Activation and Transmission of Signal to the Nucleus
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 10
pANOVA 0.00127
s.dist -0.588
p.adjustANOVA 0.0145


Top enriched genes
Top 20 genes
GeneID Gene Rank
JAG1 -9875
YWHAZ -9856
ADAM10 -9570
NCSTN -8931
APH1A -8858
PSENEN -7897
PSEN1 -7392
APH1B -5088
NOTCH4 -2061
PSEN2 7437

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JAG1 -9875
YWHAZ -9856
ADAM10 -9570
NCSTN -8931
APH1A -8858
PSENEN -7897
PSEN1 -7392
APH1B -5088
NOTCH4 -2061
PSEN2 7437


Regulation of NFE2L2 gene expression
set Regulation of NFE2L2 gene expression
setSize 8
pANOVA 0.00428
s.dist 0.583
p.adjustANOVA 0.0343


Top enriched genes
Top 20 genes
GeneID Gene Rank
NFKB1 10096
MYC 9706
NOTCH1 9662
EP300 7435
MAFK 7161
CREBBP 6506
RELA 2153
NFE2L2 49

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NFKB1 10096
MYC 9706
NOTCH1 9662
EP300 7435
MAFK 7161
CREBBP 6506
RELA 2153
NFE2L2 49


PDH complex synthesizes acetyl-CoA from PYR
set PDH complex synthesizes acetyl-CoA from PYR
setSize 5
pANOVA 0.0259
s.dist -0.575
p.adjustANOVA 0.111


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLD -9782
DLAT -8559
PDHX -5437
PDHB -4644
PDHA1 -1919

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLD -9782
DLAT -8559
PDHX -5437
PDHB -4644
PDHA1 -1919


Estrogen-stimulated signaling through PRKCZ
set Estrogen-stimulated signaling through PRKCZ
setSize 6
pANOVA 0.0154
s.dist -0.571
p.adjustANOVA 0.0825


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 -10540
NRAS -10257
PDPK1 -9575
PRKCZ -8185
KRAS -4290
HRAS 6727

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -10540
NRAS -10257
PDPK1 -9575
PRKCZ -8185
KRAS -4290
HRAS 6727


Formation of xylulose-5-phosphate
set Formation of xylulose-5-phosphate
setSize 5
pANOVA 0.0276
s.dist -0.569
p.adjustANOVA 0.115


Top enriched genes
Top 20 genes
GeneID Gene Rank
CRYL1 -9848
SORD -8209
DCXR -7632
XYLB -3993
AKR1A1 -309

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRYL1 -9848
SORD -8209
DCXR -7632
XYLB -3993
AKR1A1 -309


Small interfering RNA (siRNA) biogenesis
set Small interfering RNA (siRNA) biogenesis
setSize 9
pANOVA 0.00338
s.dist -0.564
p.adjustANOVA 0.029


Top enriched genes
Top 20 genes
GeneID Gene Rank
AGO4 -10483
TSN -10039
TSNAX -9517
PRKRA -9201
AGO1 -7549
AGO3 -5848
DICER1 -5413
AGO2 -669
TARBP2 5218

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGO4 -10483
TSN -10039
TSNAX -9517
PRKRA -9201
AGO1 -7549
AGO3 -5848
DICER1 -5413
AGO2 -669
TARBP2 5218


Abacavir ADME
set Abacavir ADME
setSize 5
pANOVA 0.0295
s.dist 0.562
p.adjustANOVA 0.12


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC22A1 11051
ABCB1 10074
ABCG2 9416
ADAL 7207
NT5C2 -5921

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC22A1 11051
ABCB1 10074
ABCG2 9416
ADAL 7207
NT5C2 -5921


H139Hfs13* PPM1K causes a mild variant of MSUD
set H139Hfs13* PPM1K causes a mild variant of MSUD
setSize 5
pANOVA 0.0295
s.dist -0.562
p.adjustANOVA 0.12


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLD -9782
BCKDHB -6081
DBT -5926
BCKDHA -5881
PPM1K -1941

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLD -9782
BCKDHB -6081
DBT -5926
BCKDHA -5881
PPM1K -1941


Maple Syrup Urine Disease
set Maple Syrup Urine Disease
setSize 5
pANOVA 0.0295
s.dist -0.562
p.adjustANOVA 0.12


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLD -9782
BCKDHB -6081
DBT -5926
BCKDHA -5881
PPM1K -1941

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLD -9782
BCKDHB -6081
DBT -5926
BCKDHA -5881
PPM1K -1941


Erythropoietin activates STAT5
set Erythropoietin activates STAT5
setSize 6
pANOVA 0.0202
s.dist -0.547
p.adjustANOVA 0.0969


Top enriched genes
Top 20 genes
GeneID Gene Rank
IRS2 -10322
LYN -7341
JAK2 -6948
STAT5B -4676
EPOR -4291
STAT5A -996

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 -10322
LYN -7341
JAK2 -6948
STAT5B -4676
EPOR -4291
STAT5A -996


Beta-oxidation of pristanoyl-CoA
set Beta-oxidation of pristanoyl-CoA
setSize 9
pANOVA 0.0045
s.dist -0.547
p.adjustANOVA 0.0353


Top enriched genes
Top 20 genes
GeneID Gene Rank
SCP2 -10092
ACOT8 -8348
ACOXL -7967
CRAT -7130
HSD17B4 -6250
CROT -5497
AMACR -5438
ACOX3 -1709
ACOX2 633

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SCP2 -10092
ACOT8 -8348
ACOXL -7967
CRAT -7130
HSD17B4 -6250
CROT -5497
AMACR -5438
ACOX3 -1709
ACOX2 633


Cytochrome c-mediated apoptotic response
set Cytochrome c-mediated apoptotic response
setSize 13
pANOVA 0.000667
s.dist -0.545
p.adjustANOVA 0.00888


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 -10540
APIP -10099
UACA -10000
CASP7 -9434
AVEN -9119
CASP3 -8463
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699
CARD8 -1228
MAPK3 7
DIABLO 4526

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -10540
APIP -10099
UACA -10000
CASP7 -9434
AVEN -9119
CASP3 -8463
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699
CARD8 -1228
MAPK3 7
DIABLO 4526


Processing and activation of SUMO
set Processing and activation of SUMO
setSize 10
pANOVA 0.00366
s.dist -0.531
p.adjustANOVA 0.0304


Top enriched genes
Top 20 genes
GeneID Gene Rank
SENP2 -9962
SUMO1 -9821
UBA2 -8248
SUMO2 -7700
SAE1 -5393
SENP5 -4801
SUMO3 -4502
SENP1 -4462
RWDD3 -1163
UBE2I 270

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SENP2 -9962
SUMO1 -9821
UBA2 -8248
SUMO2 -7700
SAE1 -5393
SENP5 -4801
SUMO3 -4502
SENP1 -4462
RWDD3 -1163
UBE2I 270


Erythrocytes take up oxygen and release carbon dioxide
set Erythrocytes take up oxygen and release carbon dioxide
setSize 7
pANOVA 0.0174
s.dist 0.519
p.adjustANOVA 0.0875


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC4A1 11154
CA1 11140
HBA1 11118
HBB 11056
CA4 5732
CA2 -2593
AQP1 -6335

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC4A1 11154
CA1 11140
HBA1 11118
HBB 11056
CA4 5732
CA2 -2593
AQP1 -6335


Protein repair
set Protein repair
setSize 6
pANOVA 0.0282
s.dist -0.517
p.adjustANOVA 0.117


Top enriched genes
Top 20 genes
GeneID Gene Rank
TXN -9480
PCMT1 -9478
MSRB2 -8058
MSRB3 -4901
MSRA -1461
MSRB1 771

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TXN -9480
PCMT1 -9478
MSRB2 -8058
MSRB3 -4901
MSRA -1461
MSRB1 771


ATF6 (ATF6-alpha) activates chaperones
set ATF6 (ATF6-alpha) activates chaperones
setSize 12
pANOVA 0.00206
s.dist -0.514
p.adjustANOVA 0.0203


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 -10141
ATF6 -9733
HSP90B1 -9271
MBTPS1 -7789
MBTPS2 -7772
ATF4 -7404
NFYB -6602
NFYC -3165
CALR -2661
XBP1 -2557
NFYA -1353
DDIT3 3741

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 -10141
ATF6 -9733
HSP90B1 -9271
MBTPS1 -7789
MBTPS2 -7772
ATF4 -7404
NFYB -6602
NFYC -3165
CALR -2661
XBP1 -2557
NFYA -1353
DDIT3 3741


Apoptosis induced DNA fragmentation
set Apoptosis induced DNA fragmentation
setSize 10
pANOVA 0.00577
s.dist -0.504
p.adjustANOVA 0.042


Top enriched genes
Top 20 genes
GeneID Gene Rank
HMGB1 -10517
H1-0 -9645
HMGB2 -9631
KPNA1 -9083
CASP3 -8463
DFFA -6777
KPNB1 -5983
DFFB -2511
H1-2 2652
H1-4 7076

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HMGB1 -10517
H1-0 -9645
HMGB2 -9631
KPNA1 -9083
CASP3 -8463
DFFA -6777
KPNB1 -5983
DFFB -2511
H1-2 2652
H1-4 7076


Miscellaneous substrates
set Miscellaneous substrates
setSize 8
pANOVA 0.0145
s.dist 0.499
p.adjustANOVA 0.0791


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP3A43 10032
CYP4F3 9847
CYP2S1 9653
CYP2D6 9605
CYP4F22 5938
CYP4F2 3578
CYP4F11 2765
CYP2U1 -5999

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP3A43 10032
CYP4F3 9847
CYP2S1 9653
CYP2D6 9605
CYP4F22 5938
CYP4F2 3578
CYP4F11 2765
CYP2U1 -5999


SUMO is transferred from E1 to E2 (UBE2I, UBC9)
set SUMO is transferred from E1 to E2 (UBE2I, UBC9)
setSize 7
pANOVA 0.0225
s.dist -0.498
p.adjustANOVA 0.103


Top enriched genes
Top 20 genes
GeneID Gene Rank
SUMO1 -9821
UBA2 -8248
SUMO2 -7700
SAE1 -5393
SUMO3 -4502
RWDD3 -1163
UBE2I 270

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUMO1 -9821
UBA2 -8248
SUMO2 -7700
SAE1 -5393
SUMO3 -4502
RWDD3 -1163
UBE2I 270


Formyl peptide receptors bind formyl peptides and many other ligands
set Formyl peptide receptors bind formyl peptides and many other ligands
setSize 7
pANOVA 0.0234
s.dist -0.495
p.adjustANOVA 0.105


Top enriched genes
Top 20 genes
GeneID Gene Rank
ANXA1 -10663
APP -9078
MT-RNR2 -7832
FPR1 -7205
HEBP1 -6869
FPR3 2195
FPR2 3153

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANXA1 -10663
APP -9078
MT-RNR2 -7832
FPR1 -7205
HEBP1 -6869
FPR3 2195
FPR2 3153


Noncanonical activation of NOTCH3
set Noncanonical activation of NOTCH3
setSize 8
pANOVA 0.0161
s.dist -0.492
p.adjustANOVA 0.0843


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCSTN -8931
APH1A -8858
PSENEN -7897
PSEN1 -7392
YBX1 -5724
APH1B -5088
NOTCH3 -4760
PSEN2 7437

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCSTN -8931
APH1A -8858
PSENEN -7897
PSEN1 -7392
YBX1 -5724
APH1B -5088
NOTCH3 -4760
PSEN2 7437


Formation of apoptosome
set Formation of apoptosome
setSize 11
pANOVA 0.00476
s.dist -0.491
p.adjustANOVA 0.0364


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 -10540
APIP -10099
UACA -10000
AVEN -9119
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699
CARD8 -1228
MAPK3 7
DIABLO 4526

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -10540
APIP -10099
UACA -10000
AVEN -9119
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699
CARD8 -1228
MAPK3 7
DIABLO 4526


Regulation of the apoptosome activity
set Regulation of the apoptosome activity
setSize 11
pANOVA 0.00476
s.dist -0.491
p.adjustANOVA 0.0364


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 -10540
APIP -10099
UACA -10000
AVEN -9119
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699
CARD8 -1228
MAPK3 7
DIABLO 4526

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -10540
APIP -10099
UACA -10000
AVEN -9119
APAF1 -7805
CYCS -5994
XIAP -3701
CASP9 -2699
CARD8 -1228
MAPK3 7
DIABLO 4526


CYP2E1 reactions
set CYP2E1 reactions
setSize 5
pANOVA 0.0578
s.dist 0.49
p.adjustANOVA 0.186


Top enriched genes
Top 20 genes
GeneID Gene Rank
CYP2S1 9653
CYP2D6 9605
CYP2A6 8868
CYP2E1 6865
CYP2C8 -7103

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP2S1 9653
CYP2D6 9605
CYP2A6 8868
CYP2E1 6865
CYP2C8 -7103


MAPK3 (ERK1) activation
set MAPK3 (ERK1) activation
setSize 10
pANOVA 0.00732
s.dist -0.49
p.adjustANOVA 0.0497


Top enriched genes
Top 20 genes
GeneID Gene Rank
IL6 -9670
MAP2K1 -9637
PTPN11 -8818
JAK2 -6948
IL6ST -6928
IL6R -3763
CDK1 -3252
JAK1 -1590
TYK2 -714
MAPK3 7

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL6 -9670
MAP2K1 -9637
PTPN11 -8818
JAK2 -6948
IL6ST -6928
IL6R -3763
CDK1 -3252
JAK1 -1590
TYK2 -714
MAPK3 7


Defects of platelet adhesion to exposed collagen
set Defects of platelet adhesion to exposed collagen
setSize 7
pANOVA 0.0253
s.dist 0.488
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA 8479
ADAMTS13 8053
GP5 7760
COL1A1 7515
GP1BB 7133
GP9 5155
VWF -5180

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA 8479
ADAMTS13 8053
GP5 7760
COL1A1 7515
GP1BB 7133
GP9 5155
VWF -5180


Beta oxidation of octanoyl-CoA to hexanoyl-CoA
set Beta oxidation of octanoyl-CoA to hexanoyl-CoA
setSize 5
pANOVA 0.0591
s.dist -0.487
p.adjustANOVA 0.188


Top enriched genes
Top 20 genes
GeneID Gene Rank
HADHA -8911
HADHB -8138
ACADM -6822
HADH -1665
ECHS1 -2

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HADHA -8911
HADHB -8138
ACADM -6822
HADH -1665
ECHS1 -2


Apoptotic cleavage of cell adhesion proteins
set Apoptotic cleavage of cell adhesion proteins
setSize 8
pANOVA 0.0175
s.dist -0.485
p.adjustANOVA 0.0875


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTNNB1 -9540
TJP2 -9172
CASP3 -8463
CDH1 -7219
DSG2 -6787
OCLN -5089
DSP 488
TJP1 5129

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTNNB1 -9540
TJP2 -9172
CASP3 -8463
CDH1 -7219
DSG2 -6787
OCLN -5089
DSP 488
TJP1 5129


Advanced glycosylation endproduct receptor signaling
set Advanced glycosylation endproduct receptor signaling
setSize 12
pANOVA 0.00367
s.dist -0.484
p.adjustANOVA 0.0304


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 -10540
HMGB1 -10517
CAPZA2 -10265
DDOST -9205
APP -9078
CAPZA1 -8994
LGALS3 -8358
PRKCSH -2166
S100A12 -930
MAPK3 7
S100B 2706
AGER 6484

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 -10540
HMGB1 -10517
CAPZA2 -10265
DDOST -9205
APP -9078
CAPZA1 -8994
LGALS3 -8358
PRKCSH -2166
S100A12 -930
MAPK3 7
S100B 2706
AGER 6484


Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
set Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
setSize 16
pANOVA 0.000809
s.dist -0.484
p.adjustANOVA 0.0103


Top enriched genes
Top 20 genes
GeneID Gene Rank
ASAH1 -10660
ATP6AP2 -10262
ATP6V1A -9893
ATP6V1C1 -9150
ATP6V1B2 -9080
ATP6V0E1 -6971
ATP6V0B -6239
ATP6V1G1 -6198
ATP6V1E1 -6134
MITF -4559
ATP6V1D -3050
ATP6V1F -2495
ATP6V1H -1089
ATP6V0A1 -834
ATP6V0C -765
ATP6V0E2 6367

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ASAH1 -10660
ATP6AP2 -10262
ATP6V1A -9893
ATP6V1C1 -9150
ATP6V1B2 -9080
ATP6V0E1 -6971
ATP6V0B -6239
ATP6V1G1 -6198
ATP6V1E1 -6134
MITF -4559
ATP6V1D -3050
ATP6V1F -2495
ATP6V1H -1089
ATP6V0A1 -834
ATP6V0C -765
ATP6V0E2 6367


MASTL Facilitates Mitotic Progression
set MASTL Facilitates Mitotic Progression
setSize 10
pANOVA 0.0081
s.dist -0.484
p.adjustANOVA 0.0536


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPP19 -10153
PPP2CB -9444
PPP2CA -8949
MASTL -5984
PPP2R1B -5914
CCNB1 -5396
CDK1 -3252
ENSA -2969
PPP2R1A 0
PPP2R2D 1423

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPP19 -10153
PPP2CB -9444
PPP2CA -8949
MASTL -5984
PPP2R1B -5914
CCNB1 -5396
CDK1 -3252
ENSA -2969
PPP2R1A 0
PPP2R2D 1423


Negative feedback regulation of MAPK pathway
set Negative feedback regulation of MAPK pathway
setSize 6
pANOVA 0.0425
s.dist -0.478
p.adjustANOVA 0.154


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAF1 -10584
MAPK1 -10540
MAP2K1 -9637
BRAF -4950
MAPK3 7
MAP2K2 5672

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAF1 -10584
MAPK1 -10540
MAP2K1 -9637
BRAF -4950
MAPK3 7
MAP2K2 5672


Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
set Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
setSize 6
pANOVA 0.043
s.dist -0.477
p.adjustANOVA 0.155


Top enriched genes
Top 20 genes
GeneID Gene Rank
HADHA -8911
HADHB -8138
ACADM -6822
MECR -4424
HADH -1665
ECHS1 -2

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HADHA -8911
HADHB -8138
ACADM -6822
MECR -4424
HADH -1665
ECHS1 -2


TGFBR3 PTM regulation
set TGFBR3 PTM regulation
setSize 10
pANOVA 0.00946
s.dist -0.474
p.adjustANOVA 0.059


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCSTN -8931
APH1A -8858
MMP14 -8305
PSENEN -7897
TIMP2 -7493
PSEN1 -7392
APH1B -5088
TGFBR3 -1707
TIMP1 -1348
PSEN2 7437

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCSTN -8931
APH1A -8858
MMP14 -8305
PSENEN -7897
TIMP2 -7493
PSEN1 -7392
APH1B -5088
TGFBR3 -1707
TIMP1 -1348
PSEN2 7437


PTK6 promotes HIF1A stabilization
set PTK6 promotes HIF1A stabilization
setSize 6
pANOVA 0.0456
s.dist -0.471
p.adjustANOVA 0.162


Top enriched genes
Top 20 genes
GeneID Gene Rank
LRRK2 -10109
HIF1A -9644
GPNMB -5543
LINC01139 -5034
HBEGF -416
PTK6 1158

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LRRK2 -10109
HIF1A -9644
GPNMB -5543
LINC01139 -5034
HBEGF -416
PTK6 1158


ER Quality Control Compartment (ERQC)
set ER Quality Control Compartment (ERQC)
setSize 21
pANOVA 0.000192
s.dist -0.47
p.adjustANOVA 0.0034


Top enriched genes
Top 20 genes
GeneID Gene Rank
MARCHF6 -10429
RNF139 -10408
DERL2 -10018
UBC -9313
SEL1L -8879
EDEM3 -8381
TRIM13 -8291
AMFR -7836
RNF5 -7578
UGGT2 -7330
RNF103 -6966
UGGT1 -6945
OS9 -6651
RNF185 -5485
EDEM2 -5045
RPS27A -4259
UBA52 -2636
MAN1B1 -1574
EDEM1 6622
SYVN1 9066

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MARCHF6 -10429
RNF139 -10408
DERL2 -10018
UBC -9313
SEL1L -8879
EDEM3 -8381
TRIM13 -8291
AMFR -7836
RNF5 -7578
UGGT2 -7330
RNF103 -6966
UGGT1 -6945
OS9 -6651
RNF185 -5485
EDEM2 -5045
RPS27A -4259
UBA52 -2636
MAN1B1 -1574
EDEM1 6622
SYVN1 9066
UBB 9170


ATF6 (ATF6-alpha) activates chaperone genes
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.0101
s.dist -0.47
p.adjustANOVA 0.0612


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPA5 -10141
ATF6 -9733
HSP90B1 -9271
ATF4 -7404
NFYB -6602
NFYC -3165
CALR -2661
XBP1 -2557
NFYA -1353
DDIT3 3741

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA5 -10141
ATF6 -9733
HSP90B1 -9271
ATF4 -7404
NFYB -6602
NFYC -3165
CALR -2661
XBP1 -2557
NFYA -1353
DDIT3 3741


Cellular response to mitochondrial stress
set Cellular response to mitochondrial stress
setSize 9
pANOVA 0.0155
s.dist -0.466
p.adjustANOVA 0.0825


Top enriched genes
Top 20 genes
GeneID Gene Rank
YME1L1 -8623
EIF2S3 -7982
EIF2S1 -6790
EIF2AK1 -6165
EIF2S2 -5498
PHB2 -4238
OMA1 -3277
DELE1 -1670
STOML2 403

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YME1L1 -8623
EIF2S3 -7982
EIF2S1 -6790
EIF2AK1 -6165
EIF2S2 -5498
PHB2 -4238
OMA1 -3277
DELE1 -1670
STOML2 403


Antigen Presentation: Folding, assembly and peptide loading of class I MHC
set Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize 30
pANOVA 1.04e-05
s.dist -0.465
p.adjustANOVA 0.000364


Top enriched genes
Top 20 genes
GeneID Gene Rank
BECN1 -10440
CANX -10427
HSPA5 -10141
ATG14 -10129
B2M -10080
SAR1B -9664
SEC24D -9519
ERAP2 -9262
HLA-H -9128
SEC31A -8995
SEC23A -8895
PIK3C3 -8708
ERAP1 -8242
HLA-E -8155
PDIA3 -7261
HLA-F -6774
BCAP31 -4842
SEC13 -3814
HLA-A -3650
HLA-G -3548

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BECN1 -10440
CANX -10427
HSPA5 -10141
ATG14 -10129
B2M -10080
SAR1B -9664
SEC24D -9519
ERAP2 -9262
HLA-H -9128
SEC31A -8995
SEC23A -8895
PIK3C3 -8708
ERAP1 -8242
HLA-E -8155
PDIA3 -7261
HLA-F -6774
BCAP31 -4842
SEC13 -3814
HLA-A -3650
HLA-G -3548
SEC24B -3215
CALR -2661
HLA-B -2577
SEC24A -1256
PIK3R4 -1131
SEC24C 1744
HLA-C 5748
TAP1 6112
TAP2 6322
TAPBP 6914


Diseases of branched-chain amino acid catabolism
set Diseases of branched-chain amino acid catabolism
setSize 13
pANOVA 0.00393
s.dist -0.462
p.adjustANOVA 0.0318


Top enriched genes
Top 20 genes
GeneID Gene Rank
DLD -9782
MCCC1 -8755
HIBCH -6617
BCKDHB -6081
BCKDK -5985
DBT -5926
BCKDHA -5881
AUH -5442
IVD -4821
PPM1K -1941
MCCC2 -1032
ACAT1 -483
ECHS1 -2

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DLD -9782
MCCC1 -8755
HIBCH -6617
BCKDHB -6081
BCKDK -5985
DBT -5926
BCKDHA -5881
AUH -5442
IVD -4821
PPM1K -1941
MCCC2 -1032
ACAT1 -483
ECHS1 -2


Gain-of-function MRAS complexes activate RAF signaling
set Gain-of-function MRAS complexes activate RAF signaling
setSize 8
pANOVA 0.0241
s.dist -0.461
p.adjustANOVA 0.107


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAF1 -10584
YWHAB -8173
PPP1CC -7595
SHOC2 -7211
PPP1CB -5395
BRAF -4950
MRAS -652
ARAF 6057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAF1 -10584
YWHAB -8173
PPP1CC -7595
SHOC2 -7211
PPP1CB -5395
BRAF -4950
MRAS -652
ARAF 6057


SHOC2 M1731 mutant abolishes MRAS complex function
set SHOC2 M1731 mutant abolishes MRAS complex function
setSize 8
pANOVA 0.0241
s.dist -0.461
p.adjustANOVA 0.107


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAF1 -10584
YWHAB -8173
PPP1CC -7595
SHOC2 -7211
PPP1CB -5395
BRAF -4950
MRAS -652
ARAF 6057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAF1 -10584
YWHAB -8173
PPP1CC -7595
SHOC2 -7211
PPP1CB -5395
BRAF -4950
MRAS -652
ARAF 6057


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          rmarkdown_2.28          zlibbioc_1.50.0        
##   [7] vctrs_0.6.5             memoise_2.0.1.9000      base64enc_0.1-3        
##  [10] htmltools_0.5.8.1       S4Arrays_1.4.1          SparseArray_1.4.8      
##  [13] Formula_1.2-5           sass_0.4.9              KernSmooth_2.23-24     
##  [16] bslib_0.8.0             htmlwidgets_1.6.4       plyr_1.8.9             
##  [19] impute_1.78.0           cachem_1.1.0            mime_0.12              
##  [22] lifecycle_1.0.4         iterators_1.0.14        pkgconfig_2.0.3        
##  [25] Matrix_1.7-0            R6_2.5.1                fastmap_1.2.0          
##  [28] GenomeInfoDbData_1.2.12 shiny_1.9.1             digest_0.6.37          
##  [31] colorspace_2.1-1        AnnotationDbi_1.66.0    Hmisc_5.1-3            
##  [34] RSQLite_2.3.7           fansi_1.0.6             httr_1.4.7             
##  [37] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [40] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [43] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [46] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [49] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [52] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [55] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [58] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [61] preprocessCore_1.66.0   tidyr_1.3.1             data.table_1.16.0      
##  [64] xml2_1.3.6              utf8_1.2.4              XVector_0.44.0         
##  [67] foreach_1.5.2           pillar_1.9.0            stringr_1.5.1          
##  [70] later_1.3.2             rJava_1.0-11            splines_4.4.1          
##  [73] lattice_0.22-6          survival_3.7-0          bit_4.5.0              
##  [76] tidyselect_1.2.1        GO.db_3.19.1            locfit_1.5-9.10        
##  [79] Biostrings_2.72.1       knitr_1.48              gridExtra_2.3          
##  [82] svglite_2.1.3           xfun_0.48               stringi_1.8.4          
##  [85] UCSC.utils_1.0.0        yaml_2.3.10             xlsxjars_0.6.1         
##  [88] evaluate_1.0.1          codetools_0.2-20        cli_3.6.3              
##  [91] rpart_4.1.23            xtable_1.8-4            systemfonts_1.1.0      
##  [94] munsell_0.5.1           jquerylib_0.1.4         Rcpp_1.0.13            
##  [97] png_0.1-8               parallel_4.4.1          blob_1.2.4             
## [100] bitops_1.0-9            viridisLite_0.4.2       scales_1.3.0           
## [103] purrr_1.0.2             crayon_1.5.3            rlang_1.1.4            
## [106] KEGGREST_1.44.1

END of report