date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 0.8879771
A1BG 0.4726792
A1BG-AS1 -1.2166884
A1CF -2.3644174
A2M -0.0234759
A2M-AS1 0.4581555

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2725
num_genes_in_profile 21870
duplicated_genes_present 0
num_profile_genes_in_sets 8802
num_profile_genes_not_in_sets 13068

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1189
num_genesets_included 1536

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Establishment of Sister Chromatid Cohesion 11 6.74e-05 -0.694 0.01080
Diseases of Mismatch Repair (MMR) 5 8.12e-03 -0.684 0.13400
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 8.20e-03 0.683 0.13400
Cohesin Loading onto Chromatin 10 2.11e-04 -0.677 0.02720
SUMO is proteolytically processed 6 4.20e-03 -0.675 0.09740
MET activates PI3K/AKT signaling 5 1.37e-02 -0.637 0.17300
Synthesis of PIPs at the late endosome membrane 11 3.48e-04 -0.623 0.03180
Phosphate bond hydrolysis by NTPDase proteins 5 1.61e-02 -0.621 0.19700
Synthesis of PIPs at the early endosome membrane 16 3.00e-05 -0.603 0.00827
Activation of caspases through apoptosome-mediated cleavage 6 1.35e-02 -0.583 0.17300
Synthesis of wybutosine at G37 of tRNA(Phe) 6 1.37e-02 -0.581 0.17300
Diseases of Base Excision Repair 5 2.80e-02 0.567 0.27700
Formation of the active cofactor, UDP-glucuronate 5 3.38e-02 -0.548 0.30100
Small interfering RNA (siRNA) biogenesis 9 4.50e-03 -0.547 0.10200
Erythrocytes take up oxygen and release carbon dioxide 7 1.28e-02 0.543 0.17300
PI-3K cascade:FGFR3 10 3.25e-03 -0.537 0.08690
Synthesis of GDP-mannose 6 2.29e-02 0.536 0.25100
ALK mutants bind TKIs 11 2.74e-03 -0.522 0.07980
Formation of the ureteric bud 5 4.50e-02 -0.518 0.35400
Gain-of-function MRAS complexes activate RAF signaling 8 1.17e-02 -0.515 0.16100
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.17e-02 -0.515 0.16100
Signaling by MRAS-complex mutants 8 1.17e-02 -0.515 0.16100
H139Hfs13* PPM1K causes a mild variant of MSUD 5 4.97e-02 -0.507 0.37000
Maple Syrup Urine Disease 5 4.97e-02 -0.507 0.37000
Synthesis of PI 5 5.36e-02 0.498 0.37400
Sulfide oxidation to sulfate 5 5.56e-02 0.494 0.37500
Processing and activation of SUMO 10 7.38e-03 -0.489 0.13200
Propionyl-CoA catabolism 5 6.02e-02 -0.485 0.38000
Wax and plasmalogen biosynthesis 5 6.51e-02 -0.476 0.39200
SUMO is conjugated to E1 (UBA2:SAE1) 5 6.71e-02 -0.473 0.39700
SMAC (DIABLO) binds to IAPs 7 3.37e-02 -0.464 0.30100
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 3.37e-02 -0.464 0.30100
SMAC, XIAP-regulated apoptotic response 7 3.37e-02 -0.464 0.30100
Biosynthesis of Lipoxins (LX) 6 4.94e-02 0.463 0.37000
Signaling by cytosolic FGFR1 fusion mutants 18 6.98e-04 -0.462 0.03440
Mitotic Telophase/Cytokinesis 13 4.51e-03 -0.455 0.10200
Cytochrome c-mediated apoptotic response 13 4.61e-03 -0.454 0.10300
Killing mechanisms 10 1.30e-02 0.454 0.17300
WNT5:FZD7-mediated leishmania damping 10 1.30e-02 0.454 0.17300
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.38e-02 -0.450 0.17300
Lysosphingolipid and LPA receptors 11 1.05e-02 0.446 0.15600
FGFR2b ligand binding and activation 6 5.92e-02 0.445 0.38000
Estrogen-stimulated signaling through PRKCZ 6 6.15e-02 -0.441 0.38500
Fructose catabolism 5 9.33e-02 0.433 0.45400
Impaired BRCA2 binding to PALB2 24 2.60e-04 -0.431 0.02950
Phenylalanine metabolism 5 9.76e-02 0.428 0.45800
Sensing of DNA Double Strand Breaks 6 7.50e-02 -0.420 0.40900
Signaling by Hippo 18 2.06e-03 -0.419 0.06740
Phenylalanine and tyrosine metabolism 9 3.13e-02 0.414 0.29500
ARMS-mediated activation 6 7.90e-02 -0.414 0.41400


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Establishment of Sister Chromatid Cohesion 11 6.74e-05 -0.694000 1.08e-02
Diseases of Mismatch Repair (MMR) 5 8.12e-03 -0.684000 1.34e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 8.20e-03 0.683000 1.34e-01
Cohesin Loading onto Chromatin 10 2.11e-04 -0.677000 2.72e-02
SUMO is proteolytically processed 6 4.20e-03 -0.675000 9.74e-02
MET activates PI3K/AKT signaling 5 1.37e-02 -0.637000 1.73e-01
Synthesis of PIPs at the late endosome membrane 11 3.48e-04 -0.623000 3.18e-02
Phosphate bond hydrolysis by NTPDase proteins 5 1.61e-02 -0.621000 1.97e-01
Synthesis of PIPs at the early endosome membrane 16 3.00e-05 -0.603000 8.27e-03
Activation of caspases through apoptosome-mediated cleavage 6 1.35e-02 -0.583000 1.73e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 1.37e-02 -0.581000 1.73e-01
Diseases of Base Excision Repair 5 2.80e-02 0.567000 2.77e-01
Formation of the active cofactor, UDP-glucuronate 5 3.38e-02 -0.548000 3.01e-01
Small interfering RNA (siRNA) biogenesis 9 4.50e-03 -0.547000 1.02e-01
Erythrocytes take up oxygen and release carbon dioxide 7 1.28e-02 0.543000 1.73e-01
PI-3K cascade:FGFR3 10 3.25e-03 -0.537000 8.69e-02
Synthesis of GDP-mannose 6 2.29e-02 0.536000 2.51e-01
ALK mutants bind TKIs 11 2.74e-03 -0.522000 7.98e-02
Formation of the ureteric bud 5 4.50e-02 -0.518000 3.54e-01
Gain-of-function MRAS complexes activate RAF signaling 8 1.17e-02 -0.515000 1.61e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.17e-02 -0.515000 1.61e-01
Signaling by MRAS-complex mutants 8 1.17e-02 -0.515000 1.61e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 4.97e-02 -0.507000 3.70e-01
Maple Syrup Urine Disease 5 4.97e-02 -0.507000 3.70e-01
Synthesis of PI 5 5.36e-02 0.498000 3.74e-01
Sulfide oxidation to sulfate 5 5.56e-02 0.494000 3.75e-01
Processing and activation of SUMO 10 7.38e-03 -0.489000 1.32e-01
Propionyl-CoA catabolism 5 6.02e-02 -0.485000 3.80e-01
Wax and plasmalogen biosynthesis 5 6.51e-02 -0.476000 3.92e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 6.71e-02 -0.473000 3.97e-01
SMAC (DIABLO) binds to IAPs 7 3.37e-02 -0.464000 3.01e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 3.37e-02 -0.464000 3.01e-01
SMAC, XIAP-regulated apoptotic response 7 3.37e-02 -0.464000 3.01e-01
Biosynthesis of Lipoxins (LX) 6 4.94e-02 0.463000 3.70e-01
Signaling by cytosolic FGFR1 fusion mutants 18 6.98e-04 -0.462000 3.44e-02
Mitotic Telophase/Cytokinesis 13 4.51e-03 -0.455000 1.02e-01
Cytochrome c-mediated apoptotic response 13 4.61e-03 -0.454000 1.03e-01
Killing mechanisms 10 1.30e-02 0.454000 1.73e-01
WNT5:FZD7-mediated leishmania damping 10 1.30e-02 0.454000 1.73e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.38e-02 -0.450000 1.73e-01
Lysosphingolipid and LPA receptors 11 1.05e-02 0.446000 1.56e-01
FGFR2b ligand binding and activation 6 5.92e-02 0.445000 3.80e-01
Estrogen-stimulated signaling through PRKCZ 6 6.15e-02 -0.441000 3.85e-01
Fructose catabolism 5 9.33e-02 0.433000 4.54e-01
Impaired BRCA2 binding to PALB2 24 2.60e-04 -0.431000 2.95e-02
Phenylalanine metabolism 5 9.76e-02 0.428000 4.58e-01
Sensing of DNA Double Strand Breaks 6 7.50e-02 -0.420000 4.09e-01
Signaling by Hippo 18 2.06e-03 -0.419000 6.74e-02
Phenylalanine and tyrosine metabolism 9 3.13e-02 0.414000 2.95e-01
ARMS-mediated activation 6 7.90e-02 -0.414000 4.14e-01
Regulation of NFE2L2 gene expression 8 4.26e-02 0.414000 3.42e-01
PDH complex synthesizes acetyl-CoA from PYR 5 1.09e-01 -0.414000 4.82e-01
PI-3K cascade:FGFR4 11 1.89e-02 -0.409000 2.18e-01
Phase 3 - rapid repolarisation 6 8.37e-02 -0.408000 4.24e-01
Glucuronidation 8 4.71e-02 -0.405000 3.64e-01
Calcitonin-like ligand receptors 5 1.18e-01 0.404000 4.88e-01
Organic anion transporters 7 6.50e-02 0.403000 3.92e-01
CREB phosphorylation 7 6.75e-02 -0.399000 3.97e-01
Signaling by LTK in cancer 7 6.93e-02 -0.396000 4.02e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.35e-02 -0.394000 2.53e-01
Post-transcriptional silencing by small RNAs 7 7.07e-02 -0.394000 4.05e-01
Diseases of hemostasis 14 1.09e-02 0.393000 1.56e-01
FGFR1 mutant receptor activation 25 7.14e-04 -0.391000 3.44e-02
Activated NTRK2 signals through FRS2 and FRS3 8 5.56e-02 -0.391000 3.75e-01
Cobalamin (Cbl) metabolism 7 7.36e-02 -0.391000 4.06e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 8.24e-04 -0.386000 3.45e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 8.24e-04 -0.386000 3.45e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 8.24e-04 -0.386000 3.45e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 8.24e-04 -0.386000 3.45e-02
Formation of apoptosome 11 2.65e-02 -0.386000 2.70e-01
Regulation of the apoptosome activity 11 2.65e-02 -0.386000 2.70e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 1.03e-01 0.384000 4.72e-01
Biosynthesis of EPA-derived SPMs 6 1.04e-01 0.383000 4.74e-01
Biosynthesis of E-series 18(S)-resolvins 5 1.39e-01 0.382000 5.28e-01
Signaling by FGFR1 in disease 32 1.90e-04 -0.381000 2.72e-02
Transcriptional regulation of testis differentiation 5 1.40e-01 0.381000 5.30e-01
Heme degradation 10 3.71e-02 0.381000 3.18e-01
Defects of platelet adhesion to exposed collagen 7 8.22e-02 0.379000 4.22e-01
Apoptotic cleavage of cell adhesion proteins 8 6.47e-02 -0.377000 3.92e-01
OAS antiviral response 8 6.49e-02 -0.377000 3.92e-01
Signaling by PDGFR in disease 19 4.95e-03 -0.372000 1.06e-01
Signaling by FGFR3 in disease 14 1.67e-02 -0.369000 1.98e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 7.33e-02 -0.366000 4.06e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 1.22e-01 0.365000 4.97e-01
Loss of Function of SMAD2/3 in Cancer 7 9.58e-02 -0.363000 4.55e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.61e-01 0.362000 5.71e-01
E2F-enabled inhibition of pre-replication complex formation 9 6.36e-02 -0.357000 3.92e-01
ROBO receptors bind AKAP5 7 1.02e-01 -0.357000 4.70e-01
PI3K events in ERBB4 signaling 6 1.30e-01 -0.357000 5.15e-01
ATF6 (ATF6-alpha) activates chaperones 12 3.28e-02 -0.356000 3.01e-01
Interleukin-2 signaling 11 4.11e-02 0.356000 3.37e-01
IFNG signaling activates MAPKs 8 8.23e-02 -0.355000 4.22e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 4.22e-02 -0.354000 3.41e-01
RHOBTB1 GTPase cycle 23 3.36e-03 -0.353000 8.87e-02
NFE2L2 regulating MDR associated enzymes 8 8.51e-02 0.352000 4.27e-01
Alpha-oxidation of phytanate 6 1.38e-01 -0.350000 5.28e-01
Degradation of cysteine and homocysteine 12 3.80e-02 0.346000 3.22e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 1.42e-01 0.346000 5.33e-01
MET activates RAP1 and RAC1 10 5.85e-02 -0.346000 3.79e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 1.16e-01 0.343000 4.88e-01
Synthesis of 5-eicosatetraenoic acids 7 1.18e-01 0.341000 4.88e-01
Repression of WNT target genes 14 2.72e-02 0.341000 2.74e-01
Adenylate cyclase activating pathway 8 9.54e-02 0.340000 4.55e-01
FasL/ CD95L signaling 5 1.89e-01 -0.339000 6.04e-01
TNFs bind their physiological receptors 25 3.46e-03 0.338000 9.00e-02
Interleukin-1 processing 8 9.82e-02 0.338000 4.59e-01
GAB1 signalosome 14 2.96e-02 -0.336000 2.84e-01
Signaling by FGFR4 in disease 11 5.57e-02 -0.333000 3.75e-01
CDC6 association with the ORC:origin complex 8 1.04e-01 -0.332000 4.74e-01
Acyl chain remodelling of PI 10 7.02e-02 -0.331000 4.05e-01
Deadenylation of mRNA 22 7.48e-03 -0.329000 1.32e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 4.82e-02 0.329000 3.67e-01
Transport of connexons to the plasma membrane 12 4.82e-02 0.329000 3.67e-01
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 5 2.02e-01 -0.329000 6.27e-01
Maturation of hRSV A proteins 13 4.05e-02 -0.328000 3.37e-01
Regulation of PTEN mRNA translation 13 4.06e-02 -0.328000 3.37e-01
Heme biosynthesis 13 4.07e-02 0.328000 3.37e-01
NF-kB is activated and signals survival 12 4.97e-02 0.327000 3.70e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 1.37e-03 -0.327000 4.89e-02
Synthesis of UDP-N-acetyl-glucosamine 8 1.09e-01 -0.327000 4.82e-01
CYP2E1 reactions 5 2.06e-01 0.327000 6.28e-01
O-glycosylation of TSR domain-containing proteins 28 2.82e-03 0.326000 7.98e-02
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 1.35e-01 -0.326000 5.26e-01
Metabolism of porphyrins 22 8.19e-03 0.326000 1.34e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 5.19e-02 0.324000 3.70e-01
IkBA variant leads to EDA-ID 7 1.39e-01 0.323000 5.28e-01
Glycerophospholipid catabolism 7 1.41e-01 0.322000 5.30e-01
Apoptosis induced DNA fragmentation 10 7.89e-02 -0.321000 4.14e-01
Impaired BRCA2 binding to RAD51 35 1.11e-03 -0.318000 4.21e-02
Tie2 Signaling 16 2.75e-02 -0.318000 2.75e-01
WNT mediated activation of DVL 8 1.19e-01 0.318000 4.92e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 3.98e-02 0.317000 3.34e-01
Linoleic acid (LA) metabolism 7 1.46e-01 0.317000 5.38e-01
Unwinding of DNA 12 5.83e-02 0.316000 3.79e-01
Relaxin receptors 5 2.23e-01 0.315000 6.47e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 8.49e-02 -0.315000 4.27e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 5.82e-04 -0.314000 3.44e-02
Signaling by PDGFRA extracellular domain mutants 12 5.97e-02 -0.314000 3.80e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 5.97e-02 -0.314000 3.80e-01
P2Y receptors 10 8.57e-02 -0.314000 4.28e-01
FRS-mediated FGFR3 signaling 12 6.06e-02 -0.313000 3.80e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 7.35e-02 0.312000 4.06e-01
CD22 mediated BCR regulation 59 3.60e-05 0.311000 8.27e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 3.20e-03 -0.311000 8.68e-02
Defective B3GALTL causes PpS 27 5.46e-03 0.309000 1.14e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 1.09e-01 -0.309000 4.82e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 6.27e-04 -0.309000 3.44e-02
Diseases of DNA Double-Strand Break Repair 41 6.27e-04 -0.309000 3.44e-02
NS1 Mediated Effects on Host Pathways 40 7.56e-04 -0.308000 3.45e-02
Formation of definitive endoderm 9 1.11e-01 -0.307000 4.86e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 5.99e-03 -0.306000 1.20e-01
Norepinephrine Neurotransmitter Release Cycle 12 6.75e-02 0.305000 3.97e-01
Signaling by FLT3 fusion proteins 18 2.53e-02 -0.305000 2.65e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.15e-01 0.304000 4.87e-01
MAPK1 (ERK2) activation 9 1.15e-01 -0.303000 4.87e-01
Cytosolic iron-sulfur cluster assembly 13 5.88e-02 0.303000 3.80e-01
Downstream signaling of activated FGFR3 17 3.09e-02 -0.302000 2.95e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.39e-01 -0.302000 5.28e-01
Regulation of NPAS4 mRNA translation 8 1.39e-01 -0.302000 5.28e-01
Pregnenolone biosynthesis 10 9.88e-02 0.301000 4.59e-01
Regulation of NPAS4 gene expression 11 8.39e-02 -0.301000 4.25e-01
VEGF binds to VEGFR leading to receptor dimerization 5 2.44e-01 0.301000 6.57e-01
VEGF ligand-receptor interactions 5 2.44e-01 0.301000 6.57e-01
Role of second messengers in netrin-1 signaling 6 2.04e-01 0.299000 6.27e-01
Integration of provirus 9 1.21e-01 -0.298000 4.96e-01
BBSome-mediated cargo-targeting to cilium 23 1.34e-02 -0.298000 1.73e-01
Loss of Function of TGFBR1 in Cancer 7 1.72e-01 -0.298000 5.90e-01
Synthesis of PIPs at the plasma membrane 52 2.07e-04 -0.297000 2.72e-02
Homologous DNA Pairing and Strand Exchange 43 7.51e-04 -0.297000 3.45e-02
N-glycan trimming and elongation in the cis-Golgi 5 2.50e-01 -0.297000 6.64e-01
Diseases associated with surfactant metabolism 5 2.51e-01 0.297000 6.64e-01
Response to metal ions 6 2.09e-01 0.296000 6.31e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 3.94e-03 -0.294000 9.61e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 3.94e-03 -0.294000 9.61e-02
NEP/NS2 Interacts with the Cellular Export Machinery 32 3.99e-03 -0.294000 9.61e-02
RHO GTPases Activate Rhotekin and Rhophilins 8 1.50e-01 0.294000 5.46e-01
SUMOylation of immune response proteins 12 7.89e-02 0.293000 4.14e-01
Fructose metabolism 7 1.80e-01 0.293000 5.96e-01
Sodium/Calcium exchangers 9 1.29e-01 -0.292000 5.13e-01
Elevation of cytosolic Ca2+ levels 13 7.05e-02 0.290000 4.05e-01
Defective binding of VWF variant to GPIb:IX:V 6 2.20e-01 0.289000 6.42e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 6 2.20e-01 0.289000 6.42e-01
ISG15 antiviral mechanism 72 2.29e-05 -0.289000 8.27e-03
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 1.87e-01 0.288000 6.02e-01
GDP-fucose biosynthesis 6 2.22e-01 0.288000 6.46e-01
MASTL Facilitates Mitotic Progression 10 1.15e-01 -0.288000 4.87e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 1.55e-03 -0.286000 5.45e-02
Branched-chain ketoacid dehydrogenase kinase deficiency 5 2.69e-01 -0.285000 6.78e-01
Vpr-mediated nuclear import of PICs 34 3.98e-03 -0.285000 9.61e-02
Acyl chain remodelling of PG 11 1.02e-01 -0.285000 4.70e-01
Signaling by KIT in disease 20 2.73e-02 -0.285000 2.74e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.73e-02 -0.285000 2.74e-01
Synthesis of pyrophosphates in the cytosol 8 1.63e-01 -0.285000 5.77e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.06e-02 -0.284000 1.56e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 2.28e-01 -0.284000 6.48e-01
TGFBR1 KD Mutants in Cancer 6 2.28e-01 -0.284000 6.48e-01
PI-3K cascade:FGFR1 13 7.64e-02 -0.284000 4.11e-01
Nef Mediated CD8 Down-regulation 7 1.94e-01 0.284000 6.11e-01
Defective GALNT12 causes CRCS1 9 1.45e-01 0.281000 5.38e-01
Transport of the SLBP independent Mature mRNA 35 4.14e-03 -0.280000 9.74e-02
Defective factor IX causes hemophilia B 6 2.35e-01 0.280000 6.55e-01
Diseases of branched-chain amino acid catabolism 13 8.13e-02 -0.279000 4.22e-01
Scavenging of heme from plasma 71 4.75e-05 0.279000 8.32e-03
Lipophagy 7 2.03e-01 -0.278000 6.27e-01
PI-3K cascade:FGFR2 13 8.29e-02 -0.278000 4.22e-01
TRIF-mediated programmed cell death 9 1.50e-01 -0.277000 5.46e-01
Golgi Associated Vesicle Biogenesis 55 4.05e-04 -0.276000 3.25e-02
Regulation of CDH11 gene transcription 5 2.86e-01 0.276000 6.94e-01
SUMOylation of SUMOylation proteins 35 4.80e-03 -0.275000 1.04e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 5.65e-02 0.275000 3.75e-01
Digestion and absorption 7 2.08e-01 0.275000 6.31e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 1.54e-01 0.274000 5.55e-01
GRB2 events in EGFR signaling 10 1.36e-01 -0.272000 5.27e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 5.95e-02 -0.272000 3.80e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 2.93e-01 -0.271000 6.97e-01
MAPK3 (ERK1) activation 10 1.38e-01 -0.271000 5.28e-01
Biosynthesis of DHA-derived SPMs 14 7.91e-02 0.271000 4.14e-01
Defective GALNT3 causes HFTC 9 1.59e-01 0.271000 5.68e-01
FLT3 signaling through SRC family kinases 6 2.51e-01 0.271000 6.64e-01
CLEC7A (Dectin-1) induces NFAT activation 11 1.20e-01 -0.270000 4.94e-01
Formation of the Editosome 6 2.51e-01 -0.270000 6.64e-01
mRNA Editing: C to U Conversion 6 2.51e-01 -0.270000 6.64e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 2.17e-01 -0.270000 6.41e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 6.21e-02 0.269000 3.87e-01
TGFBR3 PTM regulation 10 1.41e-01 -0.269000 5.30e-01
Digestion 5 2.99e-01 0.268000 6.97e-01
Activation of PUMA and translocation to mitochondria 9 1.65e-01 0.267000 5.80e-01
Trafficking and processing of endosomal TLR 13 9.62e-02 -0.266000 4.55e-01
Erythropoietin activates STAT5 6 2.58e-01 -0.266000 6.70e-01
Export of Viral Ribonucleoproteins from Nucleus 33 8.24e-03 -0.266000 1.34e-01
HDR through Single Strand Annealing (SSA) 37 5.24e-03 -0.265000 1.11e-01
Termination of O-glycan biosynthesis 16 6.63e-02 0.265000 3.96e-01
Noncanonical activation of NOTCH3 8 1.95e-01 -0.265000 6.12e-01
The canonical retinoid cycle in rods (twilight vision) 9 1.70e-01 0.264000 5.88e-01
FGFR2 ligand binding and activation 9 1.71e-01 0.264000 5.88e-01
Nuclear import of Rev protein 34 7.83e-03 -0.264000 1.34e-01
Transport of the SLBP Dependant Mature mRNA 36 6.21e-03 -0.264000 1.22e-01
RHOBTB GTPase Cycle 35 7.03e-03 -0.263000 1.28e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.89e-02 0.263000 2.81e-01
Induction of Cell-Cell Fusion 8 1.98e-01 0.263000 6.18e-01
Prolactin receptor signaling 11 1.31e-01 -0.263000 5.19e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.15e-01 -0.263000 4.87e-01
Interleukin-35 Signalling 12 1.15e-01 -0.263000 4.87e-01
Nuclear Pore Complex (NPC) Disassembly 36 6.41e-03 -0.263000 1.23e-01
NADE modulates death signalling 5 3.09e-01 -0.263000 7.04e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.01e-01 0.261000 6.25e-01
Endosomal/Vacuolar pathway 12 1.17e-01 -0.261000 4.88e-01
Fatty acids 8 2.03e-01 0.260000 6.27e-01
PI3K events in ERBB2 signaling 11 1.36e-01 -0.260000 5.27e-01
Diseases of DNA repair 51 1.34e-03 -0.260000 4.87e-02
PTK6 promotes HIF1A stabilization 6 2.71e-01 -0.260000 6.81e-01
Displacement of DNA glycosylase by APEX1 9 1.78e-01 0.259000 5.94e-01
Insulin processing 19 5.09e-02 -0.259000 3.70e-01
Post-chaperonin tubulin folding pathway 18 5.76e-02 0.259000 3.79e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 5.81e-02 0.258000 3.79e-01
Activation of RAS in B cells 5 3.19e-01 -0.257000 7.12e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.23e-01 -0.257000 4.97e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.08e-01 -0.257000 4.82e-01
FGFR1b ligand binding and activation 5 3.20e-01 0.257000 7.12e-01
Calcineurin activates NFAT 9 1.83e-01 -0.256000 6.01e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 7.85e-02 -0.254000 4.14e-01
Glutamate Neurotransmitter Release Cycle 19 5.56e-02 0.254000 3.75e-01
Signaling by BMP 23 3.55e-02 -0.253000 3.09e-01
Carboxyterminal post-translational modifications of tubulin 34 1.07e-02 0.253000 1.56e-01
Vitamin B2 (riboflavin) metabolism 6 2.84e-01 0.253000 6.93e-01
Serotonin Neurotransmitter Release Cycle 13 1.15e-01 0.252000 4.87e-01
Alternative complement activation 5 3.30e-01 0.252000 7.17e-01
SUMOylation of RNA binding proteins 47 2.86e-03 -0.251000 7.98e-02
Activation of C3 and C5 7 2.50e-01 0.251000 6.64e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.17e-01 -0.251000 4.88e-01
Constitutive Signaling by EGFRvIII 14 1.05e-01 -0.250000 4.74e-01
Signaling by EGFRvIII in Cancer 14 1.05e-01 -0.250000 4.74e-01
Anchoring fibril formation 8 2.25e-01 0.248000 6.48e-01
Transport of RCbl within the body 8 2.27e-01 0.247000 6.48e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 2.58e-01 0.247000 6.70e-01
SUMOylation of ubiquitinylation proteins 39 7.69e-03 -0.247000 1.34e-01
Interleukin-6 signaling 11 1.58e-01 -0.246000 5.66e-01
Cation-coupled Chloride cotransporters 6 2.98e-01 0.245000 6.97e-01
Metabolism of Angiotensinogen to Angiotensins 12 1.43e-01 0.244000 5.33e-01
Early Phase of HIV Life Cycle 14 1.14e-01 -0.244000 4.87e-01
Acyl chain remodelling of PC 19 6.53e-02 -0.244000 3.92e-01
Antimicrobial peptides 34 1.37e-02 0.244000 1.73e-01
Protein lipoylation 10 1.83e-01 -0.243000 6.00e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 2.13e-02 -0.243000 2.40e-01
Tryptophan catabolism 12 1.45e-01 -0.243000 5.38e-01
p130Cas linkage to MAPK signaling for integrins 11 1.63e-01 -0.243000 5.77e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 2.09e-01 0.242000 6.31e-01
Gluconeogenesis 19 6.80e-02 0.242000 3.97e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 3.49e-01 -0.242000 7.32e-01
Activated NTRK2 signals through RAS 6 3.05e-01 -0.242000 7.00e-01
Activated NTRK3 signals through RAS 6 3.05e-01 -0.242000 7.00e-01
Classical antibody-mediated complement activation 70 4.72e-04 0.242000 3.44e-02
MECP2 regulates transcription factors 5 3.50e-01 -0.241000 7.32e-01
Synthesis of PIPs at the Golgi membrane 16 9.51e-02 -0.241000 4.55e-01
Glycogen breakdown (glycogenolysis) 13 1.33e-01 0.241000 5.24e-01
Nuclear Envelope Breakdown 53 2.45e-03 -0.241000 7.50e-02
Dissolution of Fibrin Clot 12 1.52e-01 -0.239000 5.47e-01
Assembly of the ORC complex at the origin of replication 23 4.79e-02 -0.238000 3.67e-01
Erythrocytes take up carbon dioxide and release oxygen 11 1.73e-01 0.237000 5.90e-01
O2/CO2 exchange in erythrocytes 11 1.73e-01 0.237000 5.90e-01
Initial triggering of complement 80 2.45e-04 0.237000 2.95e-02
DARPP-32 events 22 5.44e-02 -0.237000 3.75e-01
Downstream signaling of activated FGFR4 18 8.21e-02 -0.237000 4.22e-01
LGI-ADAM interactions 9 2.20e-01 0.236000 6.42e-01
Depolymerization of the Nuclear Lamina 15 1.17e-01 -0.234000 4.88e-01
Phospholipase C-mediated cascade; FGFR2 8 2.53e-01 0.233000 6.65e-01
Transcriptional Regulation by E2F6 34 1.85e-02 -0.233000 2.16e-01
Heme signaling 45 6.79e-03 -0.233000 1.28e-01
Fibronectin matrix formation 6 3.24e-01 0.233000 7.16e-01
Regulation of PTEN localization 9 2.27e-01 -0.233000 6.48e-01
Acetylcholine Neurotransmitter Release Cycle 10 2.04e-01 0.232000 6.27e-01
Creation of C4 and C2 activators 72 6.71e-04 0.232000 3.44e-02
Regulation of IFNG signaling 14 1.34e-01 -0.231000 5.24e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 1.21e-01 -0.231000 4.95e-01
2-LTR circle formation 7 2.92e-01 -0.230000 6.97e-01
TICAM1-dependent activation of IRF3/IRF7 13 1.52e-01 0.230000 5.47e-01
G2/M DNA damage checkpoint 66 1.26e-03 -0.229000 4.68e-02
RUNX1 regulates estrogen receptor mediated transcription 6 3.32e-01 -0.229000 7.17e-01
NFE2L2 regulates pentose phosphate pathway genes 8 2.63e-01 0.229000 6.73e-01
Meiotic recombination 37 1.62e-02 -0.228000 1.97e-01
A tetrasaccharide linker sequence is required for GAG synthesis 18 9.38e-02 0.228000 4.55e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 2.37e-01 0.228000 6.57e-01
Interactions of Rev with host cellular proteins 37 1.66e-02 -0.227000 1.98e-01
Pausing and recovery of Tat-mediated HIV elongation 30 3.13e-02 0.227000 2.95e-01
Tat-mediated HIV elongation arrest and recovery 30 3.13e-02 0.227000 2.95e-01
RUNX2 regulates genes involved in cell migration 6 3.35e-01 0.227000 7.18e-01
G2/M DNA replication checkpoint 5 3.81e-01 -0.226000 7.56e-01
Nonhomologous End-Joining (NHEJ) 40 1.36e-02 -0.225000 1.73e-01
Cargo trafficking to the periciliary membrane 48 6.97e-03 -0.225000 1.28e-01
Signaling by FLT3 ITD and TKD mutants 15 1.33e-01 -0.224000 5.23e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 1.20e-01 -0.224000 4.94e-01
TYSND1 cleaves peroxisomal proteins 7 3.04e-01 -0.224000 7.00e-01
HDR through MMEJ (alt-NHEJ) 12 1.79e-01 -0.224000 5.96e-01
Phospholipase C-mediated cascade: FGFR1 8 2.73e-01 0.224000 6.82e-01
RHOBTB2 GTPase cycle 23 6.34e-02 -0.224000 3.92e-01
Apoptotic factor-mediated response 19 9.15e-02 -0.224000 4.48e-01
Diseases associated with O-glycosylation of proteins 50 6.29e-03 0.223000 1.22e-01
Interactions of Vpr with host cellular proteins 37 1.88e-02 -0.223000 2.18e-01
Aryl hydrocarbon receptor signalling 6 3.44e-01 -0.223000 7.27e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 3.45e-01 -0.223000 7.28e-01
Expression and translocation of olfactory receptors 52 5.58e-03 -0.222000 1.16e-01
Maturation of spike protein 9683686 5 3.91e-01 0.222000 7.60e-01
Nectin/Necl trans heterodimerization 5 3.91e-01 0.221000 7.60e-01
Zinc influx into cells by the SLC39 gene family 9 2.50e-01 0.221000 6.64e-01
FRS-mediated FGFR4 signaling 13 1.67e-01 -0.221000 5.82e-01
RHO GTPases Activate WASPs and WAVEs 35 2.43e-02 -0.220000 2.60e-01
Reversible hydration of carbon dioxide 8 2.81e-01 0.220000 6.93e-01
Creatine metabolism 6 3.52e-01 0.220000 7.33e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 3.53e-01 -0.219000 7.33e-01
IRAK4 deficiency (TLR2/4) 15 1.42e-01 -0.219000 5.33e-01
Gamma-carboxylation of protein precursors 6 3.54e-01 0.219000 7.33e-01
Regulation of TP53 Activity through Phosphorylation 88 3.95e-04 -0.218000 3.25e-02
RUNX1 regulates expression of components of tight junctions 5 3.99e-01 -0.218000 7.65e-01
IKK complex recruitment mediated by RIP1 23 7.19e-02 -0.217000 4.05e-01
FCGR activation 77 1.01e-03 0.217000 3.98e-02
Androgen biosynthesis 5 4.02e-01 -0.216000 7.66e-01
Gap junction assembly 17 1.23e-01 0.216000 4.97e-01
Formation of xylulose-5-phosphate 5 4.04e-01 -0.216000 7.66e-01
RUNX3 regulates WNT signaling 8 2.92e-01 0.215000 6.97e-01
Nucleotide-like (purinergic) receptors 14 1.63e-01 -0.215000 5.77e-01
STAT5 Activation 7 3.25e-01 -0.215000 7.17e-01
Signaling by Activin 13 1.81e-01 -0.214000 5.97e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 6.88e-04 0.214000 3.44e-02
Mitochondrial iron-sulfur cluster biogenesis 13 1.81e-01 0.214000 5.97e-01
Apoptotic execution phase 46 1.21e-02 -0.214000 1.66e-01
RAS signaling downstream of NF1 loss-of-function variants 7 3.28e-01 -0.214000 7.17e-01
PI Metabolism 79 1.05e-03 -0.213000 4.05e-02
Vitamin B1 (thiamin) metabolism 5 4.09e-01 -0.213000 7.67e-01
SHC1 events in EGFR signaling 11 2.21e-01 -0.213000 6.45e-01
AKT phosphorylates targets in the nucleus 10 2.44e-01 0.213000 6.57e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 4.42e-02 -0.212000 3.50e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 3.69e-01 0.212000 7.47e-01
RA biosynthesis pathway 13 1.87e-01 0.211000 6.02e-01
Glyoxylate metabolism and glycine degradation 13 1.88e-01 0.211000 6.02e-01
Voltage gated Potassium channels 27 5.80e-02 0.211000 3.79e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.07e-01 0.210000 6.30e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 3.05e-01 -0.210000 7.00e-01
Signaling by ERBB2 in Cancer 21 9.68e-02 -0.209000 4.55e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 4.89e-04 0.209000 3.44e-02
SUMOylation of DNA damage response and repair proteins 77 1.58e-03 -0.208000 5.45e-02
SHC-mediated cascade:FGFR3 10 2.55e-01 -0.208000 6.66e-01
PI5P Regulates TP53 Acetylation 8 3.09e-01 -0.208000 7.04e-01
EPHB-mediated forward signaling 40 2.32e-02 -0.207000 2.51e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 6.29e-04 -0.207000 3.44e-02
Amplification of signal from the kinetochores 91 6.29e-04 -0.207000 3.44e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 34 3.64e-02 -0.207000 3.15e-01
Signaling by ERBB4 45 1.63e-02 -0.207000 1.97e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.80e-01 0.207000 7.56e-01
Regulation of innate immune responses to cytosolic DNA 14 1.81e-01 0.206000 5.97e-01
Regulation of Complement cascade 97 4.52e-04 0.206000 3.44e-02
Cellular response to mitochondrial stress 9 2.84e-01 -0.206000 6.93e-01
E2F mediated regulation of DNA replication 22 9.52e-02 -0.206000 4.55e-01
Downregulation of ERBB4 signaling 8 3.14e-01 -0.205000 7.08e-01
Rev-mediated nuclear export of HIV RNA 35 3.61e-02 -0.205000 3.13e-01
ER Quality Control Compartment (ERQC) 21 1.05e-01 -0.204000 4.74e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 2.88e-01 -0.204000 6.95e-01
FGFR3 ligand binding and activation 5 4.30e-01 -0.204000 7.82e-01
FGFR3c ligand binding and activation 5 4.30e-01 -0.204000 7.82e-01
RHO GTPases Activate NADPH Oxidases 22 9.83e-02 0.204000 4.59e-01
Mitotic Spindle Checkpoint 108 2.76e-04 -0.203000 2.95e-02
Urea cycle 7 3.55e-01 0.202000 7.33e-01
Transport of nucleotide sugars 9 2.95e-01 -0.202000 6.97e-01
LTC4-CYSLTR mediated IL4 production 5 4.35e-01 -0.202000 7.84e-01
Histidine catabolism 7 3.56e-01 0.202000 7.33e-01
Germ layer formation at gastrulation 9 2.96e-01 -0.201000 6.97e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.27e-02 -0.201000 3.70e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 3.19e-04 -0.200000 3.07e-02
Antiviral mechanism by IFN-stimulated genes 140 4.25e-05 -0.200000 8.27e-03
SARS-CoV-2 modulates autophagy 11 2.50e-01 -0.200000 6.64e-01
Aspartate and asparagine metabolism 9 2.99e-01 -0.200000 6.97e-01
CD28 dependent Vav1 pathway 12 2.30e-01 -0.200000 6.48e-01
SUMOylation of chromatin organization proteins 57 9.07e-03 -0.200000 1.44e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 1.81e-01 -0.200000 5.97e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.52e-02 -0.200000 2.65e-01
DNA replication initiation 8 3.28e-01 -0.200000 7.17e-01
Transcriptional Regulation by NPAS4 27 7.48e-02 -0.198000 4.09e-01
Defective HLCS causes multiple carboxylase deficiency 7 3.65e-01 -0.198000 7.42e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.09e-01 -0.198000 4.82e-01
p75NTR signals via NF-kB 15 1.86e-01 0.197000 6.02e-01
Crosslinking of collagen fibrils 13 2.19e-01 0.197000 6.42e-01
Signaling by ERBB2 ECD mutants 15 1.87e-01 -0.197000 6.02e-01
SARS-CoV-1 modulates host translation machinery 36 4.10e-02 0.197000 3.37e-01
Synthesis of PA 31 5.85e-02 -0.196000 3.79e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 9.66e-02 0.196000 4.55e-01
Regulation of TLR by endogenous ligand 15 1.89e-01 -0.196000 6.04e-01
SLC15A4:TASL-dependent IRF5 activation 6 4.06e-01 -0.196000 7.66e-01
Metabolism of non-coding RNA 53 1.37e-02 -0.196000 1.73e-01
snRNP Assembly 53 1.37e-02 -0.196000 1.73e-01
Complement cascade 101 6.85e-04 0.196000 3.44e-02
Glutamate and glutamine metabolism 12 2.41e-01 0.195000 6.57e-01
Signaling by NTRK2 (TRKB) 20 1.32e-01 -0.195000 5.20e-01
Synthesis of Ketone Bodies 6 4.09e-01 0.194000 7.67e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 2.64e-01 0.194000 6.74e-01
Olfactory Signaling Pathway 57 1.15e-02 -0.194000 1.61e-01
G beta:gamma signalling through CDC42 17 1.67e-01 -0.193000 5.82e-01
Type I hemidesmosome assembly 8 3.44e-01 0.193000 7.27e-01
Formation of Incision Complex in GG-NER 43 2.83e-02 -0.193000 2.79e-01
RAF activation 33 5.47e-02 -0.193000 3.75e-01
Incretin synthesis, secretion, and inactivation 14 2.11e-01 -0.193000 6.34e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 2.11e-01 -0.193000 6.34e-01
SHC1 events in ERBB4 signaling 10 2.91e-01 -0.193000 6.96e-01
Sperm Motility And Taxes 6 4.14e-01 0.192000 7.69e-01
RAB geranylgeranylation 63 8.24e-03 -0.192000 1.34e-01
The activation of arylsulfatases 10 2.98e-01 -0.190000 6.97e-01
NrCAM interactions 6 4.22e-01 0.189000 7.77e-01
Signaling by NODAL 15 2.05e-01 -0.189000 6.27e-01
Keratinization 38 4.38e-02 0.189000 3.50e-01
Role of LAT2/NTAL/LAB on calcium mobilization 78 3.92e-03 0.189000 9.61e-02
Caspase activation via Death Receptors in the presence of ligand 16 1.92e-01 -0.189000 6.06e-01
Cargo concentration in the ER 31 6.96e-02 -0.188000 4.03e-01
Calnexin/calreticulin cycle 26 9.65e-02 -0.188000 4.55e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 3.56e-01 0.188000 7.33e-01
trans-Golgi Network Vesicle Budding 69 6.94e-03 -0.188000 1.28e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 3.33e-02 -0.188000 3.01e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 2.83e-01 0.187000 6.93e-01
Bicarbonate transporters 9 3.33e-01 -0.187000 7.17e-01
Acyl chain remodelling of PE 20 1.49e-01 -0.187000 5.45e-01
HIV elongation arrest and recovery 32 6.79e-02 0.186000 3.97e-01
Pausing and recovery of HIV elongation 32 6.79e-02 0.186000 3.97e-01
Resolution of Sister Chromatid Cohesion 116 5.25e-04 -0.186000 3.44e-02
Suppression of apoptosis 7 3.96e-01 0.185000 7.62e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 1.52e-01 -0.185000 5.47e-01
Peptide chain elongation 87 3.00e-03 0.184000 8.26e-02
Activation of the AP-1 family of transcription factors 10 3.14e-01 -0.184000 7.08e-01
Eukaryotic Translation Elongation 92 2.31e-03 0.184000 7.17e-02
Passive transport by Aquaporins 6 4.36e-01 -0.184000 7.85e-01
Deadenylation-dependent mRNA decay 50 2.50e-02 -0.183000 2.65e-01
CaMK IV-mediated phosphorylation of CREB 9 3.44e-01 -0.182000 7.27e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 4.81e-01 -0.182000 8.21e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 4.81e-01 -0.182000 8.21e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 2.39e-01 0.182000 6.57e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 2.39e-01 0.182000 6.57e-01
Neurofascin interactions 5 4.82e-01 0.182000 8.21e-01
DCC mediated attractive signaling 13 2.57e-01 -0.182000 6.68e-01
Plasma lipoprotein clearance 32 7.55e-02 0.182000 4.09e-01
ChREBP activates metabolic gene expression 7 4.07e-01 0.181000 7.66e-01
Regulated proteolysis of p75NTR 11 2.99e-01 -0.181000 6.97e-01
Collagen biosynthesis and modifying enzymes 46 3.41e-02 0.181000 3.02e-01
Assembly of active LPL and LIPC lipase complexes 10 3.23e-01 0.180000 7.16e-01
MECP2 regulates neuronal receptors and channels 14 2.42e-01 -0.180000 6.57e-01
Signaling by FGFR3 32 7.78e-02 -0.180000 4.14e-01
ADP signalling through P2Y purinoceptor 12 18 1.88e-01 -0.179000 6.02e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 2.45e-01 0.179000 6.58e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 5.29e-02 0.179000 3.70e-01
Platelet sensitization by LDL 16 2.16e-01 -0.179000 6.40e-01
Acyl chain remodelling of PS 14 2.47e-01 -0.179000 6.61e-01
Inhibition of Signaling by Overexpressed EGFR 5 4.90e-01 -0.178000 8.28e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 4.90e-01 -0.178000 8.28e-01
SUMOylation of DNA replication proteins 46 3.68e-02 -0.178000 3.16e-01
Hyaluronan metabolism 15 2.34e-01 0.177000 6.55e-01
Regulation of signaling by NODAL 6 4.52e-01 -0.177000 8.02e-01
Josephin domain DUBs 10 3.32e-01 0.177000 7.17e-01
Mitotic Prophase 96 2.76e-03 -0.177000 7.98e-02
Kinesins 51 2.92e-02 0.177000 2.81e-01
Regulation of HSF1-mediated heat shock response 79 6.68e-03 -0.177000 1.27e-01
FLT3 signaling in disease 27 1.14e-01 -0.176000 4.87e-01
Resolution of D-Loop Structures 35 7.25e-02 -0.175000 4.06e-01
SARS-CoV-2 modulates host translation machinery 49 3.37e-02 0.175000 3.01e-01
Formation of the cornified envelope 37 6.55e-02 0.175000 3.92e-01
Protein ubiquitination 71 1.08e-02 -0.175000 1.56e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 2.41e-01 -0.175000 6.57e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 2.41e-01 -0.175000 6.57e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 2.41e-01 -0.175000 6.57e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 2.41e-01 -0.175000 6.57e-01
Signaling by CTNNB1 phospho-site mutants 15 2.41e-01 -0.175000 6.57e-01
Signaling by GSK3beta mutants 15 2.41e-01 -0.175000 6.57e-01
HS-GAG degradation 20 1.76e-01 0.175000 5.93e-01
Signaling by ERBB2 KD Mutants 20 1.77e-01 -0.174000 5.93e-01
FCGR3A-mediated IL10 synthesis 100 2.68e-03 0.174000 7.98e-02
FOXO-mediated transcription of cell death genes 16 2.29e-01 0.174000 6.48e-01
Nef Mediated CD4 Down-regulation 9 3.67e-01 0.174000 7.45e-01
mRNA Editing 8 3.99e-01 -0.172000 7.65e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 9.30e-02 -0.172000 4.54e-01
Retinoid metabolism and transport 25 1.39e-01 0.171000 5.28e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 5.08e-01 0.171000 8.35e-01
Activation of NOXA and translocation to mitochondria 5 5.09e-01 0.171000 8.35e-01
Class I peroxisomal membrane protein import 20 1.88e-01 -0.170000 6.02e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.25e-01 -0.170000 6.48e-01
HSF1-dependent transactivation 30 1.07e-01 0.170000 4.79e-01
Retrograde transport at the Trans-Golgi-Network 49 3.99e-02 -0.170000 3.34e-01
Downstream signaling of activated FGFR2 20 1.91e-01 -0.169000 6.06e-01
Toxicity of botulinum toxin type D (botD) 5 5.15e-01 0.168000 8.36e-01
Toxicity of botulinum toxin type F (botF) 5 5.15e-01 0.168000 8.36e-01
HIV Transcription Initiation 45 5.16e-02 -0.168000 3.70e-01
RNA Polymerase II HIV Promoter Escape 45 5.16e-02 -0.168000 3.70e-01
RNA Polymerase II Promoter Escape 45 5.16e-02 -0.168000 3.70e-01
RNA Polymerase II Transcription Initiation 45 5.16e-02 -0.168000 3.70e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 5.16e-02 -0.168000 3.70e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 5.16e-02 -0.168000 3.70e-01
Uptake of dietary cobalamins into enterocytes 6 4.77e-01 0.168000 8.20e-01
Biosynthesis of maresins 6 4.77e-01 0.168000 8.20e-01
Prostanoid ligand receptors 8 4.13e-01 0.167000 7.69e-01
Platelet Adhesion to exposed collagen 15 2.63e-01 0.167000 6.73e-01
Methylation 13 2.98e-01 -0.167000 6.97e-01
Metabolism of fat-soluble vitamins 28 1.27e-01 0.167000 5.07e-01
Hydrolysis of LPC 8 4.15e-01 -0.167000 7.69e-01
Keratan sulfate degradation 9 3.87e-01 0.166000 7.59e-01
Branched-chain amino acid catabolism 21 1.87e-01 -0.166000 6.02e-01
APC truncation mutants have impaired AXIN binding 14 2.83e-01 -0.166000 6.93e-01
AXIN missense mutants destabilize the destruction complex 14 2.83e-01 -0.166000 6.93e-01
Signaling by AMER1 mutants 14 2.83e-01 -0.166000 6.93e-01
Signaling by APC mutants 14 2.83e-01 -0.166000 6.93e-01
Signaling by AXIN mutants 14 2.83e-01 -0.166000 6.93e-01
Truncations of AMER1 destabilize the destruction complex 14 2.83e-01 -0.166000 6.93e-01
NFE2L2 regulating tumorigenic genes 11 3.43e-01 0.165000 7.27e-01
Meiosis 67 1.96e-02 -0.165000 2.23e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 2.69e-01 0.165000 6.78e-01
CREB3 factors activate genes 6 4.86e-01 -0.164000 8.26e-01
MyD88 deficiency (TLR2/4) 14 2.89e-01 -0.164000 6.95e-01
Phospholipase C-mediated cascade; FGFR4 6 4.87e-01 0.164000 8.27e-01
Viral mRNA Translation 87 8.37e-03 0.164000 1.34e-01
VLDLR internalisation and degradation 15 2.73e-01 0.164000 6.82e-01
Apoptotic cleavage of cellular proteins 35 9.44e-02 -0.163000 4.55e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 1.35e-01 0.163000 5.26e-01
Ca2+ pathway 58 3.16e-02 -0.163000 2.96e-01
Glutathione synthesis and recycling 10 3.73e-01 0.163000 7.50e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 3.09e-01 -0.163000 7.04e-01
Molecules associated with elastic fibres 26 1.52e-01 0.162000 5.47e-01
Activated point mutants of FGFR2 7 4.57e-01 0.162000 8.04e-01
MAP kinase activation 63 2.60e-02 -0.162000 2.68e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 1.98e-01 -0.162000 6.19e-01
Constitutive Signaling by Overexpressed ERBB2 11 3.52e-01 -0.162000 7.33e-01
Role of phospholipids in phagocytosis 89 8.27e-03 0.162000 1.34e-01
TRAIL signaling 8 4.30e-01 -0.161000 7.82e-01
Interleukin-27 signaling 11 3.55e-01 -0.161000 7.33e-01
Eukaryotic Translation Termination 91 8.26e-03 0.160000 1.34e-01
NRIF signals cell death from the nucleus 15 2.83e-01 -0.160000 6.93e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 4.97e-01 -0.160000 8.31e-01
Elastic fibre formation 33 1.12e-01 0.160000 4.87e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.00e-01 -0.160000 6.97e-01
Negative feedback regulation of MAPK pathway 6 4.98e-01 -0.160000 8.31e-01
Neurotoxicity of clostridium toxins 8 4.34e-01 0.160000 7.83e-01
VxPx cargo-targeting to cilium 19 2.28e-01 -0.160000 6.48e-01
Regulation of RUNX1 Expression and Activity 18 2.42e-01 -0.159000 6.57e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.29e-01 -0.159000 6.48e-01
Paracetamol ADME 19 2.30e-01 0.159000 6.48e-01
Metalloprotease DUBs 20 2.20e-01 -0.159000 6.42e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.88e-01 -0.158000 6.95e-01
Signaling by TGFBR3 39 8.74e-02 -0.158000 4.32e-01
Signal amplification 28 1.49e-01 -0.158000 5.45e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 1.72e-01 -0.158000 5.90e-01
Activation of RAC1 downstream of NMDARs 7 4.71e-01 0.157000 8.19e-01
Phosphorylation of the APC/C 20 2.24e-01 -0.157000 6.47e-01
Signaling by SCF-KIT 40 8.61e-02 -0.157000 4.29e-01
Condensation of Prometaphase Chromosomes 11 3.68e-01 -0.157000 7.46e-01
Gap junction trafficking 28 1.52e-01 0.156000 5.47e-01
Interferon Signaling 240 3.05e-05 -0.156000 8.27e-03
Association of TriC/CCT with target proteins during biosynthesis 35 1.11e-01 -0.156000 4.86e-01
Activation of SMO 14 3.15e-01 0.155000 7.08e-01
Prolonged ERK activation events 13 3.33e-01 -0.155000 7.17e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.32e-02 -0.155000 2.51e-01
Initiation of Nuclear Envelope (NE) Reformation 19 2.43e-01 -0.155000 6.57e-01
Interleukin-9 signaling 8 4.49e-01 0.155000 7.99e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 3.75e-01 -0.154000 7.51e-01
FOXO-mediated transcription of cell cycle genes 14 3.17e-01 -0.154000 7.11e-01
Selenocysteine synthesis 91 1.09e-02 0.154000 1.56e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.26e-01 -0.153000 6.48e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.26e-01 -0.153000 6.48e-01
Telomere C-strand synthesis initiation 13 3.42e-01 -0.152000 7.27e-01
Processing of DNA double-strand break ends 69 2.88e-02 -0.152000 2.81e-01
GRB2 events in ERBB2 signaling 11 3.82e-01 -0.152000 7.56e-01
Defects in biotin (Btn) metabolism 8 4.57e-01 -0.152000 8.04e-01
Regulation of TP53 Activity through Association with Co-factors 13 3.43e-01 0.152000 7.27e-01
Cell Cycle Checkpoints 246 4.29e-05 -0.151000 8.27e-03
Defective pyroptosis 27 1.74e-01 -0.151000 5.91e-01
ERBB2 Regulates Cell Motility 10 4.08e-01 -0.151000 7.66e-01
Rap1 signalling 14 3.30e-01 -0.150000 7.17e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 9.60e-02 0.150000 4.55e-01
EGFR Transactivation by Gastrin 7 4.92e-01 -0.150000 8.28e-01
Cellular hexose transport 15 3.14e-01 0.150000 7.08e-01
tRNA processing in the nucleus 59 4.66e-02 -0.150000 3.64e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.01e-02 0.150000 1.56e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 4.93e-01 0.150000 8.28e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 6.51e-02 -0.149000 3.92e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 1.38e-01 -0.149000 5.28e-01
Role of ABL in ROBO-SLIT signaling 6 5.27e-01 -0.149000 8.41e-01
RHO GTPases activate KTN1 11 3.92e-01 0.149000 7.60e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 5.28e-01 -0.149000 8.41e-01
RORA activates gene expression 18 2.76e-01 -0.148000 6.87e-01
Negative regulation of FGFR3 signaling 21 2.39e-01 -0.148000 6.57e-01
SIRT1 negatively regulates rRNA expression 22 2.30e-01 -0.148000 6.48e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 3.75e-01 -0.148000 7.51e-01
Oncogenic MAPK signaling 76 2.59e-02 -0.148000 2.68e-01
Diseases associated with glycosylation precursor biosynthesis 15 3.22e-01 0.148000 7.15e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.55e-01 -0.147000 6.65e-01
Growth hormone receptor signaling 20 2.55e-01 0.147000 6.65e-01
Sulfur amino acid metabolism 22 2.34e-01 0.147000 6.54e-01
Downregulation of ERBB2:ERBB3 signaling 12 3.82e-01 0.146000 7.56e-01
Phase 2 - plateau phase 11 4.03e-01 -0.145000 7.66e-01
Ca2+ activated K+ channels 6 5.37e-01 0.145000 8.46e-01
AKT phosphorylates targets in the cytosol 14 3.47e-01 0.145000 7.30e-01
Sema4D in semaphorin signaling 22 2.39e-01 0.145000 6.57e-01
Defective C1GALT1C1 causes TNPS 10 4.28e-01 0.145000 7.82e-01
EML4 and NUDC in mitotic spindle formation 107 9.75e-03 -0.145000 1.52e-01
Beta-oxidation of very long chain fatty acids 11 4.06e-01 0.145000 7.66e-01
Glycogen synthesis 11 4.06e-01 -0.145000 7.66e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 51 7.49e-02 0.144000 4.09e-01
FCERI mediated Ca+2 mobilization 93 1.63e-02 0.144000 1.97e-01
NR1H2 and NR1H3-mediated signaling 38 1.24e-01 -0.144000 5.00e-01
Vitamin B5 (pantothenate) metabolism 20 2.65e-01 0.144000 6.75e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 5.10e-01 0.144000 8.35e-01
Signaling by FGFR in disease 52 7.34e-02 -0.143000 4.06e-01
TGFBR3 expression 20 2.67e-01 -0.143000 6.77e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 4.83e-01 -0.143000 8.23e-01
Signaling by BRAF and RAF1 fusions 60 5.51e-02 -0.143000 3.75e-01
FCERI mediated MAPK activation 94 1.65e-02 0.143000 1.97e-01
Collagen formation 64 4.77e-02 0.143000 3.67e-01
Gap junction trafficking and regulation 30 1.75e-01 0.143000 5.93e-01
PINK1-PRKN Mediated Mitophagy 31 1.68e-01 -0.143000 5.83e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 3.26e-01 -0.142000 7.17e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.46e-01 -0.142000 5.38e-01
Signaling by EGFR in Cancer 22 2.50e-01 -0.142000 6.64e-01
Processing of Intronless Pre-mRNAs 20 2.73e-01 -0.142000 6.82e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.83e-02 0.142000 2.15e-01
Regulation of MECP2 expression and activity 29 1.87e-01 -0.142000 6.02e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 3.00e-01 -0.141000 6.97e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 3.00e-01 -0.141000 6.97e-01
Sensory processing of sound by outer hair cells of the cochlea 41 1.18e-01 0.141000 4.88e-01
p75NTR negatively regulates cell cycle via SC1 5 5.85e-01 -0.141000 8.70e-01
TNFR2 non-canonical NF-kB pathway 84 2.55e-02 0.141000 2.66e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 2.54e-01 -0.141000 6.65e-01
Laminin interactions 26 2.15e-01 0.141000 6.39e-01
FGFR2 mutant receptor activation 23 2.43e-01 0.141000 6.57e-01
Signaling by FGFR4 32 1.69e-01 -0.140000 5.85e-01
Platelet calcium homeostasis 22 2.54e-01 0.140000 6.65e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 188 9.13e-04 0.140000 3.66e-02
Formation of a pool of free 40S subunits 99 1.59e-02 0.140000 1.97e-01
Interferon alpha/beta signaling 64 5.27e-02 -0.140000 3.70e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 5.92e-02 -0.140000 3.80e-01
Mismatch Repair 15 3.50e-01 -0.139000 7.32e-01
cGMP effects 12 4.03e-01 -0.139000 7.66e-01
Mitotic Prometaphase 193 8.42e-04 -0.139000 3.45e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 5.24e-01 -0.139000 8.40e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.68e-01 -0.139000 7.46e-01
Purine catabolism 16 3.36e-01 0.139000 7.19e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 4.47e-01 -0.139000 7.97e-01
TRP channels 22 2.60e-01 0.139000 6.72e-01
Maternal to zygotic transition (MZT) 72 4.23e-02 -0.138000 3.41e-01
Regulation of BACH1 activity 11 4.27e-01 -0.138000 7.81e-01
RNA polymerase II transcribes snRNA genes 71 4.41e-02 -0.138000 3.50e-01
FRS-mediated FGFR1 signaling 15 3.55e-01 -0.138000 7.33e-01
Downstream signaling of activated FGFR1 22 2.63e-01 -0.138000 6.73e-01
Myogenesis 20 2.87e-01 -0.137000 6.95e-01
Activation of Matrix Metalloproteinases 22 2.65e-01 0.137000 6.74e-01
Assembly of collagen fibrils and other multimeric structures 42 1.23e-01 0.137000 4.98e-01
Ubiquinol biosynthesis 13 3.92e-01 0.137000 7.60e-01
Mucopolysaccharidoses 11 4.31e-01 0.137000 7.83e-01
Extra-nuclear estrogen signaling 65 5.64e-02 -0.137000 3.75e-01
Other interleukin signaling 19 3.02e-01 0.137000 6.99e-01
SUMOylation 167 2.30e-03 -0.137000 7.17e-02
Interleukin-12 family signaling 53 8.57e-02 -0.136000 4.28e-01
Toll Like Receptor 9 (TLR9) Cascade 108 1.46e-02 -0.136000 1.82e-01
Interleukin-17 signaling 68 5.28e-02 -0.136000 3.70e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 5.34e-01 -0.136000 8.46e-01
Chemokine receptors bind chemokines 41 1.34e-01 0.135000 5.24e-01
rRNA modification in the mitochondrion 8 5.10e-01 0.134000 8.35e-01
Abacavir ADME 5 6.04e-01 0.134000 8.75e-01
Stimuli-sensing channels 80 3.86e-02 0.134000 3.26e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 5.40e-01 0.134000 8.46e-01
TRAF3-dependent IRF activation pathway 13 4.04e-01 0.134000 7.66e-01
Pyrimidine salvage 10 4.65e-01 0.134000 8.12e-01
Maturation of nucleoprotein 9694631 15 3.71e-01 -0.134000 7.49e-01
mRNA Splicing - Minor Pathway 50 1.03e-01 0.133000 4.72e-01
RHOH GTPase cycle 33 1.85e-01 -0.133000 6.02e-01
Formation of tubulin folding intermediates by CCT/TriC 21 2.90e-01 0.133000 6.96e-01
Regulation of CDH11 function 9 4.90e-01 0.133000 8.28e-01
NFE2L2 regulating ER-stress associated genes 5 6.07e-01 0.133000 8.77e-01
FRS-mediated FGFR2 signaling 15 3.74e-01 -0.133000 7.51e-01
Ub-specific processing proteases 153 4.63e-03 -0.133000 1.03e-01
TNFR1-induced proapoptotic signaling 24 2.61e-01 0.133000 6.73e-01
RMTs methylate histone arginines 35 1.76e-01 0.132000 5.93e-01
Interleukin-7 signaling 21 2.96e-01 0.132000 6.97e-01
HDR through Homologous Recombination (HRR) 68 6.02e-02 -0.132000 3.80e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 5.77e-01 0.131000 8.66e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 3.34e-01 -0.131000 7.17e-01
Dopamine Neurotransmitter Release Cycle 18 3.34e-01 0.131000 7.17e-01
Gene Silencing by RNA 87 3.50e-02 -0.131000 3.06e-01
RHOF GTPase cycle 38 1.63e-01 -0.131000 5.77e-01
Defensins 8 5.24e-01 -0.130000 8.40e-01
RUNX3 regulates p14-ARF 10 4.78e-01 0.130000 8.20e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.82e-01 0.130000 6.93e-01
Neurotransmitter release cycle 35 1.85e-01 0.129000 6.02e-01
DNA Damage Bypass 47 1.25e-01 -0.129000 5.01e-01
Regulation of HMOX1 expression and activity 5 6.18e-01 -0.129000 8.84e-01
Mitochondrial calcium ion transport 22 2.96e-01 -0.129000 6.97e-01
tRNA processing in the mitochondrion 24 2.77e-01 -0.128000 6.89e-01
SOS-mediated signalling 7 5.57e-01 -0.128000 8.54e-01
Free fatty acids regulate insulin secretion 10 4.84e-01 -0.128000 8.23e-01
Aggrephagy 34 1.97e-01 0.128000 6.17e-01
SHC-related events triggered by IGF1R 7 5.58e-01 -0.128000 8.54e-01
RNA Polymerase II Pre-transcription Events 77 5.26e-02 -0.128000 3.70e-01
SHC1 events in ERBB2 signaling 17 3.62e-01 -0.128000 7.39e-01
RHOD GTPase cycle 49 1.22e-01 -0.128000 4.97e-01
G-protein beta:gamma signalling 29 2.35e-01 -0.127000 6.55e-01
Attachment and Entry 9694614 15 3.93e-01 0.127000 7.60e-01
NPAS4 regulates expression of target genes 16 3.78e-01 -0.127000 7.55e-01
CTLA4 inhibitory signaling 21 3.14e-01 -0.127000 7.08e-01
Attenuation phase 23 2.92e-01 0.127000 6.97e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.29e-01 -0.127000 7.82e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 8.45e-02 -0.127000 4.26e-01
Signaling by Erythropoietin 24 2.83e-01 -0.127000 6.93e-01
tRNA processing 128 1.35e-02 -0.126000 1.73e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 5.63e-01 -0.126000 8.57e-01
Circadian Clock 67 7.37e-02 -0.126000 4.06e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 1.90e-01 -0.126000 6.05e-01
Signaling by FGFR2 IIIa TM 18 3.54e-01 0.126000 7.33e-01
Adenylate cyclase inhibitory pathway 11 4.69e-01 0.126000 8.17e-01
Transport of Mature Transcript to Cytoplasm 81 4.98e-02 -0.126000 3.70e-01
RHO GTPases activate PAKs 20 3.30e-01 -0.126000 7.17e-01
PKA activation in glucagon signalling 14 4.15e-01 0.126000 7.69e-01
Beta-oxidation of pristanoyl-CoA 9 5.14e-01 -0.126000 8.36e-01
Viral Messenger RNA Synthesis 44 1.49e-01 -0.126000 5.46e-01
Cholesterol biosynthesis 26 2.68e-01 0.126000 6.77e-01
Diseases of glycosylation 110 2.31e-02 0.125000 2.51e-01
Formation of paraxial mesoderm 52 1.18e-01 0.125000 4.88e-01
Intra-Golgi traffic 43 1.57e-01 -0.125000 5.63e-01
DAP12 interactions 39 1.78e-01 -0.125000 5.94e-01
Transcriptional activation of mitochondrial biogenesis 52 1.20e-01 -0.125000 4.94e-01
Respiratory Syncytial Virus Infection Pathway 99 3.21e-02 -0.125000 2.99e-01
Synaptic adhesion-like molecules 17 3.74e-01 0.125000 7.51e-01
DAP12 signaling 28 2.54e-01 -0.125000 6.65e-01
Synthesis of bile acids and bile salts 26 2.72e-01 -0.124000 6.82e-01
Phosphate bond hydrolysis by NUDT proteins 7 5.69e-01 -0.124000 8.60e-01
Advanced glycosylation endproduct receptor signaling 12 4.57e-01 -0.124000 8.04e-01
Transcriptional regulation by small RNAs 61 9.41e-02 -0.124000 4.55e-01
CD163 mediating an anti-inflammatory response 9 5.21e-01 0.124000 8.40e-01
ADP signalling through P2Y purinoceptor 1 21 3.27e-01 -0.124000 7.17e-01
HIV Life Cycle 144 1.06e-02 -0.123000 1.56e-01
Interleukin-18 signaling 6 6.01e-01 0.123000 8.75e-01
Packaging Of Telomere Ends 18 3.65e-01 -0.123000 7.42e-01
Interleukin-12 signaling 44 1.57e-01 -0.123000 5.63e-01
Mitotic Anaphase 211 2.06e-03 -0.123000 6.74e-02
PERK regulates gene expression 31 2.36e-01 -0.123000 6.56e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 3.81e-01 0.123000 7.56e-01
Separation of Sister Chromatids 168 6.05e-03 -0.123000 1.20e-01
Cell-extracellular matrix interactions 15 4.10e-01 0.123000 7.68e-01
Mitotic Metaphase and Anaphase 212 2.11e-03 -0.123000 6.76e-02
Nuclear signaling by ERBB4 24 2.99e-01 -0.122000 6.97e-01
TNFR1-mediated ceramide production 6 6.04e-01 0.122000 8.75e-01
Sema3A PAK dependent Axon repulsion 16 3.98e-01 0.122000 7.65e-01
Cellular response to starvation 147 1.06e-02 0.122000 1.56e-01
VEGFR2 mediated cell proliferation 18 3.71e-01 -0.122000 7.49e-01
Miscellaneous substrates 8 5.51e-01 0.122000 8.53e-01
Signal regulatory protein family interactions 13 4.47e-01 -0.122000 7.97e-01
PD-1 signaling 28 2.65e-01 0.122000 6.75e-01
G beta:gamma signalling through BTK 15 4.16e-01 -0.121000 7.69e-01
tRNA modification in the nucleus and cytosol 43 1.69e-01 -0.121000 5.85e-01
Reproduction 86 5.23e-02 -0.121000 3.70e-01
Methionine salvage pathway 6 6.08e-01 -0.121000 8.77e-01
Phospholipid metabolism 183 4.76e-03 -0.121000 1.04e-01
Formation of the beta-catenin:TCF transactivating complex 44 1.66e-01 0.121000 5.80e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 2.96e-01 -0.121000 6.97e-01
Erythropoietin activates RAS 13 4.53e-01 -0.120000 8.03e-01
CRMPs in Sema3A signaling 14 4.36e-01 0.120000 7.85e-01
Toll-like Receptor Cascades 162 8.35e-03 -0.120000 1.34e-01
Regulation of TP53 Activity 153 1.04e-02 -0.120000 1.56e-01
Collagen degradation 42 1.78e-01 0.120000 5.94e-01
PECAM1 interactions 12 4.72e-01 -0.120000 8.19e-01
Transcription of the HIV genome 67 8.96e-02 -0.120000 4.42e-01
RIP-mediated NFkB activation via ZBP1 17 3.93e-01 0.120000 7.60e-01
RHOV GTPase cycle 36 2.15e-01 -0.120000 6.39e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 3.49e-02 -0.119000 3.06e-01
ERK/MAPK targets 22 3.33e-01 -0.119000 7.17e-01
Activation of the pre-replicative complex 32 2.44e-01 -0.119000 6.57e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.14e-01 -0.119000 7.08e-01
FCERI mediated NF-kB activation 130 1.93e-02 0.119000 2.22e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 2.96e-01 0.118000 6.97e-01
Neurexins and neuroligins 38 2.08e-01 0.118000 6.31e-01
Malate-aspartate shuttle 8 5.65e-01 0.117000 8.59e-01
Interferon gamma signaling 90 5.44e-02 -0.117000 3.75e-01
RNA Polymerase I Transcription Termination 30 2.66e-01 -0.117000 6.75e-01
Class B/2 (Secretin family receptors) 57 1.26e-01 0.117000 5.04e-01
Cilium Assembly 187 5.75e-03 -0.117000 1.18e-01
Listeria monocytogenes entry into host cells 17 4.04e-01 -0.117000 7.66e-01
Cellular response to heat stress 94 5.03e-02 -0.117000 3.70e-01
PCP/CE pathway 75 8.10e-02 0.117000 4.22e-01
Opioid Signalling 75 8.12e-02 -0.116000 4.22e-01
Vitamin C (ascorbate) metabolism 8 5.69e-01 0.116000 8.60e-01
Synthesis of PIPs at the ER membrane 5 6.52e-01 -0.116000 9.01e-01
Receptor-type tyrosine-protein phosphatases 11 5.04e-01 -0.116000 8.35e-01
FGFRL1 modulation of FGFR1 signaling 7 5.95e-01 0.116000 8.74e-01
SUMO E3 ligases SUMOylate target proteins 161 1.10e-02 -0.116000 1.56e-01
Diseases of mitotic cell cycle 38 2.16e-01 -0.116000 6.41e-01
Downregulation of TGF-beta receptor signaling 26 3.07e-01 -0.116000 7.03e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 3.70e-01 -0.116000 7.49e-01
Signaling by ALK 24 3.27e-01 0.116000 7.17e-01
Fatty acyl-CoA biosynthesis 35 2.37e-01 -0.115000 6.57e-01
FGFR2 alternative splicing 25 3.18e-01 0.115000 7.12e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 1.26e-01 0.115000 5.04e-01
GABA synthesis, release, reuptake and degradation 11 5.09e-01 0.115000 8.35e-01
Frs2-mediated activation 11 5.09e-01 -0.115000 8.35e-01
Synthesis of PG 8 5.74e-01 0.115000 8.65e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 37 2.27e-01 -0.115000 6.48e-01
Signaling by EGFR 47 1.74e-01 -0.115000 5.91e-01
Anti-inflammatory response favouring Leishmania parasite infection 133 2.26e-02 0.115000 2.50e-01
Leishmania parasite growth and survival 133 2.26e-02 0.115000 2.50e-01
Defective B3GAT3 causes JDSSDHD 12 4.93e-01 0.114000 8.28e-01
Sema4D induced cell migration and growth-cone collapse 19 3.89e-01 0.114000 7.59e-01
RHO GTPases activate IQGAPs 25 3.23e-01 0.114000 7.16e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 3.05e-01 0.114000 7.00e-01
Axonal growth inhibition (RHOA activation) 7 6.04e-01 0.113000 8.75e-01
p75NTR regulates axonogenesis 7 6.04e-01 0.113000 8.75e-01
Pyruvate metabolism 44 1.94e-01 -0.113000 6.11e-01
O-linked glycosylation 85 7.20e-02 0.113000 4.05e-01
Complex I biogenesis 66 1.13e-01 0.113000 4.87e-01
Gene expression (Transcription) 1404 1.40e-12 -0.113000 2.71e-09
Recognition of DNA damage by PCNA-containing replication complex 30 2.85e-01 -0.113000 6.93e-01
COPI-independent Golgi-to-ER retrograde traffic 45 1.92e-01 -0.112000 6.07e-01
RNA Polymerase II Transcription 1197 6.77e-11 -0.112000 6.52e-08
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.68e-01 -0.112000 8.17e-01
Basigin interactions 21 3.75e-01 0.112000 7.51e-01
Formation of annular gap junctions 10 5.41e-01 0.112000 8.47e-01
p75NTR recruits signalling complexes 12 5.03e-01 0.112000 8.34e-01
Phosphorylation of Emi1 6 6.36e-01 0.112000 8.94e-01
PKR-mediated signaling 67 1.14e-01 -0.112000 4.87e-01
Degradation of DVL 43 2.06e-01 0.111000 6.28e-01
Processing of SMDT1 15 4.56e-01 -0.111000 8.04e-01
Sema4D mediated inhibition of cell attachment and migration 7 6.10e-01 0.111000 8.78e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 5.87e-01 -0.111000 8.71e-01
Plasma lipoprotein remodeling 18 4.16e-01 0.111000 7.69e-01
RAB GEFs exchange GTP for GDP on RABs 88 7.30e-02 -0.111000 4.06e-01
Late Phase of HIV Life Cycle 131 2.90e-02 -0.110000 2.81e-01
Transcriptional regulation of granulopoiesis 44 2.05e-01 0.110000 6.27e-01
CASP8 activity is inhibited 11 5.27e-01 -0.110000 8.41e-01
Dimerization of procaspase-8 11 5.27e-01 -0.110000 8.41e-01
Regulation by c-FLIP 11 5.27e-01 -0.110000 8.41e-01
RUNX3 regulates NOTCH signaling 14 4.76e-01 0.110000 8.20e-01
Regulation of expression of SLITs and ROBOs 148 2.09e-02 0.110000 2.37e-01
DNA Damage/Telomere Stress Induced Senescence 42 2.18e-01 -0.110000 6.42e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 4.77e-01 0.110000 8.20e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 2.43e-01 -0.109000 6.57e-01
Nucleosome assembly 38 2.43e-01 -0.109000 6.57e-01
Downstream signal transduction 27 3.25e-01 -0.109000 7.17e-01
Collagen chain trimerization 27 3.25e-01 0.109000 7.17e-01
RHOG GTPase cycle 70 1.14e-01 -0.109000 4.87e-01
Hyaluronan uptake and degradation 12 5.13e-01 0.109000 8.36e-01
Generic Transcription Pathway 1079 1.43e-09 -0.109000 9.18e-07
SHC-mediated cascade:FGFR4 11 5.31e-01 -0.109000 8.45e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 3.46e-01 0.109000 7.30e-01
IL-6-type cytokine receptor ligand interactions 13 4.97e-01 0.109000 8.31e-01
Translocation of ZAP-70 to Immunological synapse 24 3.56e-01 0.109000 7.33e-01
Signaling by TGFB family members 137 2.79e-02 -0.109000 2.77e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 6.03e-02 -0.109000 3.80e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.53e-01 -0.108000 8.53e-01
CD209 (DC-SIGN) signaling 20 4.02e-01 -0.108000 7.66e-01
Extracellular matrix organization 219 5.84e-03 0.108000 1.18e-01
AMPK inhibits chREBP transcriptional activation activity 6 6.47e-01 -0.108000 8.98e-01
DNA strand elongation 32 2.90e-01 0.108000 6.96e-01
Prevention of phagosomal-lysosomal fusion 9 5.77e-01 0.107000 8.66e-01
MyD88 dependent cascade initiated on endosome 101 6.23e-02 -0.107000 3.87e-01
M Phase 346 6.09e-04 -0.107000 3.44e-02
RNA Polymerase I Promoter Escape 45 2.13e-01 -0.107000 6.39e-01
Interleukin-4 and Interleukin-13 signaling 92 7.57e-02 0.107000 4.09e-01
Proton-coupled monocarboxylate transport 6 6.50e-01 -0.107000 8.99e-01
Ribavirin ADME 11 5.39e-01 0.107000 8.46e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.82e-01 0.107000 5.99e-01
APOBEC3G mediated resistance to HIV-1 infection 5 6.79e-01 0.107000 9.15e-01
MyD88 cascade initiated on plasma membrane 95 7.20e-02 -0.107000 4.05e-01
Toll Like Receptor 10 (TLR10) Cascade 95 7.20e-02 -0.107000 4.05e-01
Toll Like Receptor 5 (TLR5) Cascade 95 7.20e-02 -0.107000 4.05e-01
PKA activation 15 4.74e-01 0.107000 8.20e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 5.40e-01 0.107000 8.46e-01
Synthesis of diphthamide-EEF2 8 6.02e-01 0.106000 8.75e-01
Defective B4GALT7 causes EDS, progeroid type 12 5.24e-01 0.106000 8.40e-01
RAF-independent MAPK1/3 activation 22 3.89e-01 -0.106000 7.59e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.32e-01 0.106000 7.17e-01
Response to elevated platelet cytosolic Ca2+ 109 5.61e-02 -0.106000 3.75e-01
TNFR1-induced NF-kappa-B signaling pathway 32 3.01e-01 0.106000 6.98e-01
TP53 Regulates Transcription of Cell Death Genes 43 2.31e-01 0.106000 6.49e-01
SUMOylation of transcription cofactors 44 2.27e-01 -0.105000 6.48e-01
Transcriptional Regulation by MECP2 49 2.03e-01 -0.105000 6.27e-01
NCAM1 interactions 26 3.56e-01 0.105000 7.33e-01
Arachidonate production from DAG 5 6.86e-01 0.105000 9.16e-01
Blood group systems biosynthesis 17 4.56e-01 0.104000 8.04e-01
Anchoring of the basal body to the plasma membrane 97 7.54e-02 -0.104000 4.09e-01
RHO GTPases Activate Formins 128 4.15e-02 -0.104000 3.39e-01
IRAK1 recruits IKK complex 14 5.00e-01 -0.104000 8.33e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 5.00e-01 -0.104000 8.33e-01
Glycosaminoglycan metabolism 98 7.57e-02 0.104000 4.09e-01
Physiological factors 9 5.90e-01 0.104000 8.74e-01
Signaling by MAPK mutants 6 6.60e-01 -0.104000 9.06e-01
G2/M Checkpoints 126 4.50e-02 -0.103000 3.54e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 3.91e-01 -0.103000 7.60e-01
Nef and signal transduction 8 6.13e-01 0.103000 8.80e-01
Platelet degranulation 105 6.72e-02 -0.103000 3.97e-01
PI3K/AKT activation 8 6.13e-01 -0.103000 8.80e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 2.84e-01 -0.103000 6.93e-01
Nitric oxide stimulates guanylate cyclase 15 4.90e-01 -0.103000 8.28e-01
ZBP1(DAI) mediated induction of type I IFNs 20 4.26e-01 0.103000 7.81e-01
Activation of RAC1 11 5.55e-01 -0.103000 8.54e-01
Visual phototransduction 61 1.65e-01 0.103000 5.80e-01
NOD1/2 Signaling Pathway 36 2.87e-01 -0.103000 6.95e-01
Triglyceride catabolism 15 4.92e-01 -0.102000 8.28e-01
SLBP independent Processing of Histone Pre-mRNAs 10 5.77e-01 -0.102000 8.66e-01
SLC transporter disorders 76 1.24e-01 -0.102000 5.00e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 3.34e-01 -0.102000 7.17e-01
Resolution of Abasic Sites (AP sites) 38 2.78e-01 0.102000 6.90e-01
Negative regulation of FGFR4 signaling 22 4.09e-01 -0.102000 7.67e-01
Respiratory electron transport 149 3.29e-02 0.101000 3.01e-01
Potential therapeutics for SARS 150 3.25e-02 0.101000 3.01e-01
Regulation of PTEN gene transcription 59 1.79e-01 0.101000 5.96e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 6.96e-01 0.101000 9.19e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.42e-02 0.101000 3.92e-01
Nonsense-Mediated Decay (NMD) 113 6.42e-02 0.101000 3.92e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 5.46e-01 0.101000 8.50e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 2.23e-01 -0.101000 6.47e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 5.31e-01 -0.100000 8.45e-01
Organelle biogenesis and maintenance 278 3.98e-03 -0.100000 9.61e-02
Nuclear events stimulated by ALK signaling in cancer 33 3.20e-01 0.100000 7.12e-01
Complex III assembly 23 4.06e-01 0.100000 7.66e-01
Processing of Capped Intron-Containing Pre-mRNA 279 4.08e-03 -0.099900 9.70e-02
WNT5A-dependent internalization of FZD4 13 5.34e-01 0.099600 8.46e-01
Cytosolic sulfonation of small molecules 18 4.66e-01 0.099200 8.15e-01
Regulation of TNFR1 signaling 47 2.40e-01 0.099100 6.57e-01
PTK6 Regulates Cell Cycle 6 6.74e-01 -0.099100 9.13e-01
Translesion synthesis by POLK 17 4.80e-01 -0.099000 8.21e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 5.37e-01 0.098900 8.46e-01
MyD88-independent TLR4 cascade 108 7.67e-02 -0.098600 4.11e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 7.67e-02 -0.098600 4.11e-01
Late endosomal microautophagy 30 3.50e-01 0.098600 7.32e-01
Maturation of nucleoprotein 9683610 11 5.72e-01 -0.098500 8.63e-01
Synthesis of PC 23 4.14e-01 -0.098400 7.69e-01
Assembly Of The HIV Virion 15 5.10e-01 0.098200 8.35e-01
Signaling by TGF-beta Receptor Complex 90 1.08e-01 -0.098000 4.81e-01
MAPK6/MAPK4 signaling 69 1.60e-01 -0.097900 5.69e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 7.89e-02 -0.097900 4.14e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 7.89e-02 -0.097900 4.14e-01
Signaling by ERBB2 44 2.63e-01 -0.097500 6.73e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 7.06e-01 -0.097500 9.19e-01
POLB-Dependent Long Patch Base Excision Repair 8 6.34e-01 -0.097300 8.92e-01
Meiotic synapsis 43 2.71e-01 -0.097000 6.81e-01
Class I MHC mediated antigen processing & presentation 345 1.99e-03 -0.096900 6.73e-02
Defective LFNG causes SCDO3 5 7.08e-01 -0.096900 9.19e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 2.14e-01 0.096800 6.39e-01
RND1 GTPase cycle 36 3.15e-01 -0.096800 7.08e-01
ERBB2 Activates PTK6 Signaling 8 6.36e-01 0.096500 8.94e-01
Dual Incision in GG-NER 41 2.85e-01 -0.096500 6.93e-01
MET promotes cell motility 34 3.31e-01 -0.096400 7.17e-01
COPII-mediated vesicle transport 67 1.72e-01 -0.096400 5.90e-01
RAS processing 23 4.24e-01 0.096200 7.80e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 4.05e-01 -0.096200 7.66e-01
Mitochondrial translation elongation 90 1.15e-01 0.096200 4.87e-01
Toll Like Receptor 2 (TLR2) Cascade 109 8.31e-02 -0.096100 4.22e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 8.31e-02 -0.096100 4.22e-01
RHO GTPases Activate ROCKs 18 4.80e-01 -0.096100 8.21e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 7.10e-01 0.096000 9.21e-01
Spry regulation of FGF signaling 16 5.06e-01 -0.096000 8.35e-01
TRAF6 mediated NF-kB activation 23 4.26e-01 0.095800 7.81e-01
RHOJ GTPase cycle 49 2.46e-01 -0.095800 6.59e-01
Smooth Muscle Contraction 34 3.34e-01 -0.095700 7.17e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 4.60e-01 -0.095400 8.06e-01
Trafficking of AMPA receptors 20 4.60e-01 -0.095400 8.06e-01
Regulation of KIT signaling 15 5.26e-01 -0.094700 8.41e-01
Pyrimidine catabolism 9 6.23e-01 0.094600 8.87e-01
RUNX2 regulates osteoblast differentiation 19 4.75e-01 0.094600 8.20e-01
CD28 co-stimulation 33 3.47e-01 -0.094600 7.30e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 4.42e-01 -0.094600 7.93e-01
SUMOylation of intracellular receptors 26 4.04e-01 -0.094600 7.66e-01
RSV-host interactions 78 1.51e-01 -0.094000 5.47e-01
TBC/RABGAPs 45 2.76e-01 0.093900 6.87e-01
EPH-Ephrin signaling 81 1.45e-01 -0.093700 5.38e-01
Diseases of carbohydrate metabolism 29 3.84e-01 0.093300 7.57e-01
Nucleotide catabolism 28 3.93e-01 -0.093200 7.60e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 6.10e-01 -0.093200 8.78e-01
Nicotinamide salvaging 16 5.20e-01 -0.093000 8.40e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.08e-01 -0.092800 8.35e-01
FLT3 signaling by CBL mutants 7 6.71e-01 0.092700 9.13e-01
Glutathione conjugation 27 4.05e-01 0.092600 7.66e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 6.72e-01 -0.092400 9.13e-01
DNA Repair 289 6.93e-03 -0.092300 1.28e-01
Membrane binding and targetting of GAG proteins 13 5.65e-01 0.092300 8.59e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.65e-01 0.092300 8.59e-01
ESR-mediated signaling 157 4.60e-02 -0.092300 3.61e-01
Retrograde neurotrophin signalling 12 5.80e-01 0.092300 8.66e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 5.11e-01 0.092000 8.36e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.46e-01 0.092000 7.30e-01
Sensory perception of taste 22 4.56e-01 0.091900 8.04e-01
Potassium Channels 64 2.04e-01 0.091700 6.27e-01
IRS-mediated signalling 35 3.48e-01 -0.091700 7.30e-01
Negative epigenetic regulation of rRNA expression 63 2.10e-01 -0.091400 6.32e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 5.54e-01 -0.091400 8.54e-01
ECM proteoglycans 47 2.79e-01 0.091200 6.93e-01
PPARA activates gene expression 105 1.08e-01 -0.090900 4.81e-01
L13a-mediated translational silencing of Ceruloplasmin expression 109 1.02e-01 0.090600 4.70e-01
Signaling by the B Cell Receptor (BCR) 151 5.46e-02 0.090600 3.75e-01
Notch-HLH transcription pathway 28 4.07e-01 0.090500 7.66e-01
Synthesis of Dolichyl-phosphate 6 7.01e-01 0.090400 9.19e-01
Selenoamino acid metabolism 114 9.66e-02 0.090100 4.55e-01
XBP1(S) activates chaperone genes 44 3.02e-01 0.089900 6.99e-01
eNOS activation 11 6.06e-01 -0.089900 8.76e-01
Inflammasomes 21 4.78e-01 0.089500 8.20e-01
SARS-CoV-2-host interactions 182 3.76e-02 -0.089400 3.20e-01
Formation of the Early Elongation Complex 33 3.76e-01 0.089100 7.51e-01
Formation of the HIV-1 Early Elongation Complex 33 3.76e-01 0.089100 7.51e-01
Butyrophilin (BTN) family interactions 10 6.26e-01 0.089000 8.87e-01
MECP2 regulates transcription of neuronal ligands 5 7.31e-01 0.088900 9.29e-01
Nuclear Envelope (NE) Reassembly 68 2.05e-01 -0.088900 6.27e-01
RSK activation 7 6.85e-01 -0.088600 9.16e-01
Assembly and cell surface presentation of NMDA receptors 34 3.73e-01 0.088400 7.50e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 5.68e-01 -0.088200 8.60e-01
Glucagon-type ligand receptors 20 4.98e-01 0.087600 8.31e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.62e-01 -0.087500 6.73e-01
Triglyceride metabolism 24 4.58e-01 -0.087400 8.06e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.07e-01 -0.087000 7.03e-01
Defects in vitamin and cofactor metabolism 21 4.90e-01 -0.087000 8.28e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 6.90e-01 0.086900 9.19e-01
Asymmetric localization of PCP proteins 49 2.93e-01 0.086900 6.97e-01
Deubiquitination 225 2.50e-02 -0.086700 2.65e-01
Degradation of the extracellular matrix 96 1.43e-01 0.086500 5.33e-01
Signaling by MET 68 2.18e-01 -0.086400 6.42e-01
Beta-catenin phosphorylation cascade 17 5.38e-01 -0.086300 8.46e-01
Complex IV assembly 45 3.17e-01 0.086300 7.11e-01
CLEC7A/inflammasome pathway 6 7.14e-01 0.086300 9.21e-01
DNA Double-Strand Break Repair 137 8.14e-02 -0.086200 4.22e-01
Sphingolipid catabolism 11 6.21e-01 -0.086200 8.86e-01
PRC2 methylates histones and DNA 27 4.38e-01 -0.086200 7.88e-01
Regulation of PLK1 Activity at G2/M Transition 87 1.66e-01 -0.085900 5.80e-01
Somitogenesis 41 3.42e-01 0.085800 7.27e-01
Mitochondrial RNA degradation 25 4.60e-01 -0.085500 8.06e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 4.18e-02 -0.085400 3.40e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.17e-01 0.085400 9.21e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.17e-01 0.085400 9.21e-01
Cell Cycle 611 3.14e-04 -0.085400 3.07e-02
Generation of second messenger molecules 38 3.63e-01 0.085300 7.40e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 4.27e-01 -0.085300 7.81e-01
HCMV Late Events 67 2.29e-01 -0.085000 6.48e-01
Semaphorin interactions 57 2.67e-01 0.084900 6.77e-01
Fertilization 13 5.96e-01 0.084800 8.75e-01
Regulation of pyruvate metabolism 32 4.06e-01 -0.084800 7.66e-01
Regulation of lipid metabolism by PPARalpha 107 1.30e-01 -0.084800 5.15e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 5.57e-01 -0.084700 8.54e-01
Translesion synthesis by POLI 17 5.46e-01 -0.084500 8.50e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 5.84e-01 0.084400 8.70e-01
Membrane Trafficking 574 5.47e-04 -0.084400 3.44e-02
Cap-dependent Translation Initiation 117 1.15e-01 0.084300 4.87e-01
Eukaryotic Translation Initiation 117 1.15e-01 0.084300 4.87e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 5.99e-01 0.084200 8.75e-01
DNA Double Strand Break Response 47 3.19e-01 -0.084000 7.12e-01
Effects of PIP2 hydrolysis 24 4.77e-01 0.083800 8.20e-01
Ion channel transport 141 8.63e-02 0.083700 4.29e-01
Cell surface interactions at the vascular wall 173 5.81e-02 0.083500 3.79e-01
DNA methylation 18 5.40e-01 0.083500 8.46e-01
FGFR1 ligand binding and activation 10 6.50e-01 0.082900 8.99e-01
Miro GTPase Cycle 8 6.85e-01 -0.082800 9.16e-01
Protein hydroxylation 17 5.56e-01 0.082500 8.54e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 7.50e-01 0.082100 9.32e-01
FLT3 Signaling 38 3.82e-01 -0.082000 7.56e-01
Formation of axial mesoderm 6 7.29e-01 0.081800 9.29e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 1.39e-01 0.081800 5.28e-01
Receptor Mediated Mitophagy 11 6.39e-01 -0.081700 8.96e-01
RAC2 GTPase cycle 85 1.93e-01 -0.081700 6.09e-01
TGFBR3 regulates TGF-beta signaling 8 6.89e-01 -0.081600 9.19e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 6.10e-01 -0.081600 8.78e-01
Mitophagy 38 3.84e-01 -0.081500 7.57e-01
Negative regulation of MET activity 18 5.50e-01 -0.081500 8.52e-01
G alpha (s) signalling events 96 1.68e-01 0.081400 5.83e-01
Senescence-Associated Secretory Phenotype (SASP) 65 2.58e-01 0.081200 6.70e-01
Drug ADME 57 2.90e-01 0.081000 6.96e-01
Clathrin-mediated endocytosis 126 1.17e-01 -0.080900 4.88e-01
Early SARS-CoV-2 Infection Events 32 4.32e-01 -0.080300 7.83e-01
Toll Like Receptor 4 (TLR4) Cascade 138 1.03e-01 -0.080300 4.73e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 5.80e-01 -0.080000 8.66e-01
Netrin-1 signaling 35 4.13e-01 0.079900 7.69e-01
Regulation of TP53 Activity through Acetylation 29 4.57e-01 0.079800 8.04e-01
Sphingolipid de novo biosynthesis 35 4.15e-01 -0.079600 7.69e-01
Cell Cycle, Mitotic 488 2.83e-03 -0.078900 7.98e-02
Integrin cell surface interactions 65 2.72e-01 0.078700 6.82e-01
Interleukin receptor SHC signaling 23 5.13e-01 0.078700 8.36e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 2.13e-01 -0.078500 6.39e-01
RUNX2 regulates bone development 24 5.06e-01 0.078500 8.35e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.16e-01 -0.078100 6.41e-01
Formation of Fibrin Clot (Clotting Cascade) 26 4.93e-01 0.077600 8.28e-01
Diseases of metabolism 204 5.61e-02 0.077600 3.75e-01
Purine salvage 12 6.42e-01 -0.077600 8.97e-01
Activation of ATR in response to replication stress 37 4.15e-01 -0.077400 7.69e-01
Signaling by Non-Receptor Tyrosine Kinases 47 3.59e-01 -0.077300 7.35e-01
Signaling by PTK6 47 3.59e-01 -0.077300 7.35e-01
Processing of Capped Intronless Pre-mRNA 29 4.71e-01 -0.077300 8.19e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 6.44e-01 0.077100 8.97e-01
alpha-linolenic acid (ALA) metabolism 12 6.44e-01 0.077100 8.97e-01
Regulation of TP53 Degradation 35 4.30e-01 -0.077100 7.82e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 5.94e-01 -0.077000 8.74e-01
Regulation of actin dynamics for phagocytic cup formation 124 1.39e-01 0.077000 5.28e-01
Common Pathway of Fibrin Clot Formation 13 6.32e-01 0.076800 8.91e-01
Formation of TC-NER Pre-Incision Complex 51 3.43e-01 -0.076700 7.27e-01
Specification of primordial germ cells 6 7.45e-01 -0.076600 9.32e-01
HIV Infection 213 5.50e-02 -0.076300 3.75e-01
Phase 0 - rapid depolarisation 24 5.18e-01 -0.076300 8.40e-01
Removal of the Flap Intermediate from the C-strand 17 5.86e-01 -0.076200 8.71e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.10e-01 -0.076200 8.35e-01
NoRC negatively regulates rRNA expression 60 3.09e-01 -0.076000 7.04e-01
Nephrin family interactions 20 5.56e-01 -0.076000 8.54e-01
Interleukin-21 signaling 9 6.93e-01 0.076000 9.19e-01
Peroxisomal lipid metabolism 27 4.95e-01 -0.075800 8.31e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 6.25e-01 0.075500 8.87e-01
Reduction of cytosolic Ca++ levels 9 6.95e-01 -0.075400 9.19e-01
Folding of actin by CCT/TriC 10 6.80e-01 -0.075400 9.15e-01
Activation of Ca-permeable Kainate Receptor 9 6.96e-01 0.075300 9.19e-01
Ionotropic activity of kainate receptors 9 6.96e-01 0.075300 9.19e-01
G beta:gamma signalling through PLC beta 17 5.91e-01 -0.075200 8.74e-01
Presynaptic function of Kainate receptors 17 5.91e-01 -0.075200 8.74e-01
ROS and RNS production in phagocytes 30 4.79e-01 0.074700 8.20e-01
Signaling by ALK fusions and activated point mutants 89 2.24e-01 -0.074600 6.47e-01
Signaling by ALK in cancer 89 2.24e-01 -0.074600 6.47e-01
Chondroitin sulfate biosynthesis 12 6.55e-01 0.074600 9.02e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 3.32e-02 -0.074500 3.01e-01
G-protein activation 19 5.74e-01 -0.074500 8.65e-01
EPHA-mediated growth cone collapse 21 5.55e-01 -0.074400 8.54e-01
Toll Like Receptor 3 (TLR3) Cascade 104 1.90e-01 -0.074300 6.05e-01
Signalling to RAS 19 5.75e-01 0.074300 8.66e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.59e-01 0.074200 7.35e-01
NCAM signaling for neurite out-growth 47 3.80e-01 0.074100 7.56e-01
RAC3 GTPase cycle 87 2.32e-01 -0.074100 6.52e-01
Molybdenum cofactor biosynthesis 6 7.53e-01 -0.074000 9.33e-01
Metabolic disorders of biological oxidation enzymes 23 5.39e-01 0.074000 8.46e-01
Interleukin-37 signaling 19 5.77e-01 -0.073800 8.66e-01
Regulation of localization of FOXO transcription factors 12 6.58e-01 0.073800 9.06e-01
IRS-related events triggered by IGF1R 36 4.44e-01 -0.073700 7.94e-01
GPCR ligand binding 245 4.71e-02 0.073700 3.64e-01
Defective Intrinsic Pathway for Apoptosis 24 5.33e-01 0.073600 8.46e-01
Signaling by activated point mutants of FGFR1 5 7.77e-01 0.073200 9.38e-01
APC-Cdc20 mediated degradation of Nek2A 26 5.19e-01 -0.073100 8.40e-01
Mitochondrial translation termination 90 2.35e-01 0.072400 6.55e-01
Signaling by Nuclear Receptors 210 7.11e-02 -0.072300 4.05e-01
G-protein mediated events 44 4.08e-01 -0.072100 7.66e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 7.60e-01 -0.072100 9.34e-01
Interleukin-2 family signaling 38 4.43e-01 0.071900 7.94e-01
Cyclin D associated events in G1 47 3.96e-01 -0.071600 7.62e-01
G1 Phase 47 3.96e-01 -0.071600 7.62e-01
Dual incision in TC-NER 63 3.26e-01 -0.071600 7.17e-01
Nuclear events mediated by NFE2L2 82 2.63e-01 0.071500 6.73e-01
Signaling by FGFR1 42 4.23e-01 -0.071400 7.79e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 6.83e-01 0.071100 9.16e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 4.26e-01 0.071000 7.81e-01
FCGR3A-mediated phagocytosis 122 1.77e-01 0.070800 5.93e-01
Leishmania phagocytosis 122 1.77e-01 0.070800 5.93e-01
Parasite infection 122 1.77e-01 0.070800 5.93e-01
Condensation of Prophase Chromosomes 27 5.24e-01 -0.070800 8.40e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 4.52e-01 0.070600 8.02e-01
Protein-protein interactions at synapses 58 3.53e-01 0.070500 7.33e-01
RHO GTPase Effectors 259 5.10e-02 -0.070400 3.70e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.15e-01 -0.070400 6.39e-01
Platelet activation, signaling and aggregation 221 7.19e-02 -0.070300 4.05e-01
Metabolism of folate and pterines 16 6.27e-01 0.070200 8.87e-01
activated TAK1 mediates p38 MAPK activation 23 5.60e-01 -0.070200 8.56e-01
Glycogen metabolism 22 5.69e-01 0.070200 8.60e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 6.50e-01 -0.070100 8.99e-01
Keratan sulfate/keratin metabolism 28 5.22e-01 0.069800 8.40e-01
Inositol phosphate metabolism 42 4.34e-01 -0.069800 7.83e-01
Insulin receptor signalling cascade 40 4.45e-01 -0.069700 7.95e-01
Mitochondrial translation initiation 90 2.53e-01 0.069700 6.65e-01
Post-translational protein modification 1245 3.73e-05 -0.069500 8.27e-03
Golgi-to-ER retrograde transport 123 1.84e-01 -0.069400 6.01e-01
Interleukin-10 signaling 39 4.55e-01 0.069100 8.04e-01
Tandem pore domain potassium channels 5 7.89e-01 -0.069000 9.42e-01
Oxidative Stress Induced Senescence 77 2.95e-01 -0.069000 6.97e-01
Ethanol oxidation 7 7.52e-01 0.068900 9.33e-01
NGF-stimulated transcription 32 5.01e-01 0.068700 8.34e-01
UCH proteinases 73 3.12e-01 0.068500 7.08e-01
Glycolysis 68 3.30e-01 -0.068300 7.17e-01
MITF-M-regulated melanocyte development 113 2.10e-01 -0.068200 6.33e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 3.27e-01 0.068200 7.17e-01
VEGFA-VEGFR2 Pathway 92 2.59e-01 -0.068100 6.71e-01
Metabolism of carbohydrates 241 6.87e-02 0.068100 4.00e-01
DNA Damage Reversal 8 7.40e-01 -0.067800 9.32e-01
Other semaphorin interactions 16 6.39e-01 0.067700 8.96e-01
Signalling to ERKs 32 5.08e-01 -0.067600 8.35e-01
Interaction between L1 and Ankyrins 27 5.43e-01 0.067600 8.49e-01
Neddylation 216 8.74e-02 -0.067500 4.32e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 7.58e-01 0.067300 9.34e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 5.69e-01 -0.067100 8.60e-01
GPVI-mediated activation cascade 32 5.12e-01 -0.067000 8.36e-01
Syndecan interactions 25 5.62e-01 -0.066900 8.57e-01
IRE1alpha activates chaperones 46 4.32e-01 0.066900 7.83e-01
RHOC GTPase cycle 71 3.30e-01 -0.066900 7.17e-01
Suppression of phagosomal maturation 12 6.89e-01 -0.066800 9.19e-01
Diseases of signal transduction by growth factor receptors and second messengers 401 2.21e-02 -0.066600 2.47e-01
Transport of vitamins, nucleosides, and related molecules 31 5.21e-01 0.066500 8.40e-01
mRNA 3’-end processing 57 3.85e-01 -0.066500 7.57e-01
mRNA Splicing 211 9.62e-02 -0.066400 4.55e-01
HCMV Early Events 84 2.94e-01 -0.066200 6.97e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 3.10e-01 0.066100 7.04e-01
NFE2L2 regulating inflammation associated genes 5 7.99e-01 0.065900 9.47e-01
RHO GTPases activate PKNs 46 4.40e-01 -0.065800 7.90e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 5.21e-01 -0.065500 8.40e-01
Mitochondrial unfolded protein response (UPRmt) 17 6.42e-01 0.065100 8.97e-01
Non-integrin membrane-ECM interactions 49 4.32e-01 0.064900 7.83e-01
Eicosanoid ligand-binding receptors 13 6.86e-01 0.064800 9.16e-01
mRNA Capping 29 5.47e-01 -0.064600 8.50e-01
Alpha-protein kinase 1 signaling pathway 11 7.11e-01 -0.064600 9.21e-01
Reversal of alkylation damage by DNA dioxygenases 7 7.67e-01 -0.064600 9.34e-01
mRNA Splicing - Major Pathway 203 1.13e-01 -0.064500 4.87e-01
Mitochondrial biogenesis 91 2.89e-01 -0.064400 6.95e-01
Amino acids regulate mTORC1 48 4.41e-01 0.064300 7.91e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 7.85e-01 0.064300 9.42e-01
Activation of NMDA receptors and postsynaptic events 74 3.39e-01 -0.064300 7.24e-01
Vif-mediated degradation of APOBEC3G 41 4.77e-01 0.064200 8.20e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 7.12e-01 -0.064200 9.21e-01
Sphingolipid metabolism 92 2.88e-01 -0.064000 6.95e-01
Gap junction degradation 11 7.14e-01 0.063800 9.21e-01
Regulation of beta-cell development 22 6.05e-01 0.063700 8.75e-01
Regulation of TP53 Expression and Degradation 36 5.08e-01 -0.063700 8.35e-01
Reelin signalling pathway 5 8.06e-01 0.063500 9.50e-01
Pentose phosphate pathway 13 6.92e-01 -0.063500 9.19e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 6.60e-01 -0.063500 9.06e-01
NOTCH2 intracellular domain regulates transcription 11 7.16e-01 -0.063400 9.21e-01
Kidney development 17 6.51e-01 -0.063400 9.00e-01
Disorders of Developmental Biology 12 7.04e-01 0.063300 9.19e-01
Disorders of Nervous System Development 12 7.04e-01 0.063300 9.19e-01
Loss of function of MECP2 in Rett syndrome 12 7.04e-01 0.063300 9.19e-01
Pervasive developmental disorders 12 7.04e-01 0.063300 9.19e-01
Mitochondrial protein import 63 3.85e-01 0.063300 7.57e-01
Formation of the nephric duct 8 7.57e-01 0.063200 9.34e-01
Negative regulation of FLT3 15 6.72e-01 0.063200 9.13e-01
Disorders of transmembrane transporters 136 2.05e-01 -0.063000 6.27e-01
RAF/MAP kinase cascade 225 1.05e-01 0.062700 4.74e-01
Negative regulation of the PI3K/AKT network 91 3.02e-01 -0.062500 6.99e-01
Signal attenuation 9 7.46e-01 0.062500 9.32e-01
Triglyceride biosynthesis 9 7.46e-01 -0.062300 9.32e-01
Acetylcholine regulates insulin secretion 9 7.46e-01 0.062300 9.32e-01
Metabolism of lipids 641 7.13e-03 -0.062300 1.28e-01
Bacterial Infection Pathways 65 3.85e-01 -0.062300 7.57e-01
rRNA processing in the nucleus and cytosol 189 1.41e-01 0.062000 5.31e-01
RIPK1-mediated regulated necrosis 31 5.50e-01 -0.062000 8.52e-01
Regulation of necroptotic cell death 31 5.50e-01 -0.062000 8.52e-01
Eicosanoids 8 7.62e-01 -0.061900 9.34e-01
Homology Directed Repair 110 2.62e-01 -0.061900 6.73e-01
G2 Phase 5 8.11e-01 0.061600 9.54e-01
IGF1R signaling cascade 37 5.18e-01 -0.061500 8.40e-01
Platelet Aggregation (Plug Formation) 29 5.68e-01 0.061300 8.60e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 6.12e-01 0.061100 8.80e-01
Apoptosis 158 1.86e-01 -0.061000 6.02e-01
Signaling by Insulin receptor 63 4.03e-01 -0.060900 7.66e-01
Signaling by Rho GTPases 607 1.05e-02 -0.060800 1.56e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 623 9.73e-03 -0.060700 1.52e-01
Signaling by PDGF 48 4.67e-01 -0.060700 8.15e-01
Downstream signaling events of B Cell Receptor (BCR) 68 3.88e-01 -0.060600 7.59e-01
TP53 Regulates Metabolic Genes 78 3.55e-01 -0.060500 7.33e-01
Epigenetic regulation of gene expression 264 9.07e-02 -0.060500 4.45e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 6.48e-01 0.060500 8.99e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 7.98e-01 -0.060400 9.47e-01
TCF dependent signaling in response to WNT 152 1.99e-01 0.060300 6.21e-01
SARS-CoV-2 Infection 267 9.07e-02 -0.060100 4.45e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 1.66e-01 0.060000 5.80e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 7.43e-01 -0.060000 9.32e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 7.32e-01 -0.059700 9.29e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 7.84e-01 0.059700 9.42e-01
Biotin transport and metabolism 11 7.32e-01 0.059700 9.29e-01
Peptide ligand-binding receptors 102 2.98e-01 0.059700 6.97e-01
rRNA processing 213 1.34e-01 0.059600 5.24e-01
Nephron development 5 8.17e-01 0.059600 9.55e-01
Peroxisomal protein import 58 4.33e-01 -0.059500 7.83e-01
PI3K Cascade 31 5.67e-01 -0.059400 8.60e-01
Cargo recognition for clathrin-mediated endocytosis 87 3.39e-01 -0.059300 7.24e-01
Class A/1 (Rhodopsin-like receptors) 177 1.74e-01 0.059200 5.91e-01
Aspirin ADME 15 6.92e-01 0.059100 9.19e-01
B-WICH complex positively regulates rRNA expression 45 4.93e-01 -0.059100 8.28e-01
Signaling by Retinoic Acid 29 5.82e-01 0.059100 8.67e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 7.73e-01 0.058800 9.37e-01
Zygotic genome activation (ZGA) 5 8.20e-01 -0.058700 9.55e-01
Signaling by ERBB2 TMD/JMD mutants 17 6.76e-01 -0.058500 9.14e-01
HATs acetylate histones 92 3.32e-01 -0.058500 7.17e-01
Phase I - Functionalization of compounds 68 4.06e-01 0.058300 7.66e-01
Intrinsic Pathway of Fibrin Clot Formation 15 6.96e-01 0.058200 9.19e-01
ADORA2B mediated anti-inflammatory cytokines production 36 5.46e-01 -0.058100 8.50e-01
Leishmania infection 213 1.46e-01 0.057900 5.38e-01
Parasitic Infection Pathways 213 1.46e-01 0.057900 5.38e-01
Phase 4 - resting membrane potential 9 7.64e-01 0.057800 9.34e-01
Inwardly rectifying K+ channels 23 6.32e-01 -0.057800 8.91e-01
AURKA Activation by TPX2 72 3.97e-01 -0.057700 7.64e-01
DNA Replication Pre-Initiation 103 3.13e-01 -0.057500 7.08e-01
Ubiquitin-dependent degradation of Cyclin D 39 5.34e-01 0.057500 8.46e-01
RHO GTPases activate CIT 18 6.73e-01 -0.057400 9.13e-01
Sialic acid metabolism 28 6.00e-01 -0.057300 8.75e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 5.26e-01 0.057200 8.41e-01
Fanconi Anemia Pathway 36 5.53e-01 -0.057200 8.53e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 5.22e-01 0.057100 8.40e-01
HIV Transcription Elongation 42 5.22e-01 0.057100 8.40e-01
Tat-mediated elongation of the HIV-1 transcript 42 5.22e-01 0.057100 8.40e-01
Adherens junctions interactions 38 5.43e-01 0.057100 8.49e-01
Signaling by RAF1 mutants 37 5.49e-01 -0.057000 8.52e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 5.38e-01 0.056900 8.46e-01
p53-Independent DNA Damage Response 39 5.38e-01 0.056900 8.46e-01
p53-Independent G1/S DNA damage checkpoint 39 5.38e-01 0.056900 8.46e-01
IRAK2 mediated activation of TAK1 complex 10 7.55e-01 -0.056900 9.34e-01
Cytoprotection by HMOX1 53 4.74e-01 0.056800 8.20e-01
Glycerophospholipid biosynthesis 105 3.14e-01 -0.056800 7.08e-01
S Phase 150 2.30e-01 -0.056700 6.48e-01
MET receptor recycling 9 7.68e-01 -0.056700 9.34e-01
Metabolism of RNA 717 9.79e-03 -0.056600 1.52e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 3.93e-01 -0.056600 7.60e-01
Loss of Nlp from mitotic centrosomes 69 4.16e-01 -0.056600 7.69e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 4.16e-01 -0.056600 7.69e-01
Xenobiotics 12 7.34e-01 -0.056500 9.31e-01
rRNA modification in the nucleus and cytosol 60 4.50e-01 -0.056400 8.00e-01
Negative regulation of FGFR2 signaling 24 6.33e-01 -0.056200 8.92e-01
RHO GTPase cycle 411 5.09e-02 -0.056100 3.70e-01
HSF1 activation 26 6.21e-01 0.056000 8.86e-01
Activation of AMPK downstream of NMDARs 20 6.66e-01 0.055700 9.08e-01
Influenza Viral RNA Transcription and Replication 134 2.69e-01 0.055300 6.78e-01
Signaling by ROBO receptors 188 1.91e-01 0.055300 6.06e-01
Signaling by VEGF 99 3.42e-01 -0.055200 7.27e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 5.62e-01 0.055100 8.57e-01
Metabolism of amino acids and derivatives 305 9.88e-02 0.055000 4.59e-01
Negative regulation of FGFR1 signaling 25 6.34e-01 -0.055000 8.92e-01
Nucleotide salvage 21 6.63e-01 0.054900 9.07e-01
Activation of GABAB receptors 30 6.03e-01 0.054800 8.75e-01
GABA B receptor activation 30 6.03e-01 0.054800 8.75e-01
SRP-dependent cotranslational protein targeting to membrane 110 3.22e-01 0.054700 7.15e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.17e-01 -0.054600 8.84e-01
Formation of ATP by chemiosmotic coupling 20 6.74e-01 0.054400 9.13e-01
Interleukin-23 signaling 7 8.04e-01 -0.054300 9.50e-01
LDL clearance 17 6.99e-01 0.054200 9.19e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 7.45e-01 -0.054200 9.32e-01
Processive synthesis on the C-strand of the telomere 19 6.84e-01 -0.053900 9.16e-01
Arachidonate metabolism 47 5.24e-01 0.053800 8.40e-01
Intrinsic Pathway for Apoptosis 54 4.99e-01 -0.053200 8.32e-01
MAPK1/MAPK3 signaling 231 1.64e-01 0.053100 5.79e-01
TGF-beta receptor signaling activates SMADs 45 5.39e-01 -0.052900 8.46e-01
Pre-NOTCH Processing in Golgi 18 6.99e-01 -0.052600 9.19e-01
Gastrulation 76 4.28e-01 0.052600 7.82e-01
Regulation of insulin secretion 63 4.70e-01 -0.052600 8.19e-01
Prostacyclin signalling through prostacyclin receptor 16 7.16e-01 -0.052600 9.21e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 6.37e-01 -0.052500 8.94e-01
Cell junction organization 78 4.24e-01 0.052400 7.80e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 6.45e-01 -0.052300 8.97e-01
Estrogen-dependent gene expression 96 3.78e-01 -0.052000 7.55e-01
Metabolism of vitamins and cofactors 167 2.48e-01 0.051800 6.64e-01
MITF-M-dependent gene expression 84 4.12e-01 -0.051800 7.69e-01
Amyloid fiber formation 51 5.23e-01 0.051700 8.40e-01
Bile acid and bile salt metabolism 30 6.25e-01 -0.051500 8.87e-01
Nucleotide biosynthesis 12 7.58e-01 0.051400 9.34e-01
Asparagine N-linked glycosylation 286 1.35e-01 -0.051300 5.26e-01
Regulation of RUNX3 expression and activity 45 5.52e-01 0.051300 8.53e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 7.90e-01 0.051200 9.42e-01
Metabolism of proteins 1775 3.63e-04 -0.051000 3.18e-02
Intraflagellar transport 47 5.46e-01 -0.050900 8.50e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 5.43e-01 0.050700 8.49e-01
Deactivation of the beta-catenin transactivating complex 36 5.99e-01 0.050600 8.75e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 5.61e-01 0.050600 8.57e-01
RNA Polymerase I Promoter Opening 17 7.18e-01 0.050500 9.22e-01
Glycosphingolipid catabolism 31 6.27e-01 -0.050500 8.87e-01
FGFR4 ligand binding and activation 5 8.46e-01 0.050300 9.60e-01
Cristae formation 33 6.18e-01 0.050100 8.84e-01
Degradation of beta-catenin by the destruction complex 72 4.64e-01 0.049900 8.12e-01
Cellular Senescence 143 3.03e-01 -0.049900 6.99e-01
Translation of Structural Proteins 9683701 29 6.46e-01 0.049200 8.98e-01
Neurotransmitter receptors and postsynaptic signal transmission 139 3.17e-01 -0.049200 7.11e-01
SCF-beta-TrCP mediated degradation of Emi1 42 5.82e-01 0.049100 8.67e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 7.19e-01 -0.049000 9.22e-01
Transcriptional Regulation by TP53 346 1.18e-01 -0.048900 4.88e-01
C-type lectin receptors (CLRs) 118 3.59e-01 -0.048800 7.35e-01
PKMTs methylate histone lysines 43 5.79e-01 -0.048800 8.66e-01
Maturation of protein 3a 9683673 9 8.00e-01 0.048700 9.48e-01
Maturation of protein 3a 9694719 9 8.00e-01 0.048700 9.48e-01
Ion transport by P-type ATPases 44 5.77e-01 0.048500 8.66e-01
Metal ion SLC transporters 19 7.14e-01 -0.048500 9.21e-01
Programmed Cell Death 187 2.53e-01 -0.048500 6.65e-01
RNA Polymerase II Transcription Termination 66 4.96e-01 -0.048400 8.31e-01
Mitochondrial translation 96 4.13e-01 0.048400 7.69e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 5.93e-01 -0.048200 8.74e-01
Signaling by RAS mutants 41 5.93e-01 -0.048200 8.74e-01
Signaling by moderate kinase activity BRAF mutants 41 5.93e-01 -0.048200 8.74e-01
Signaling downstream of RAS mutants 41 5.93e-01 -0.048200 8.74e-01
Peptide hormone metabolism 53 5.44e-01 -0.048200 8.49e-01
Mitochondrial Uncoupling 6 8.38e-01 0.048100 9.59e-01
Nucleotide Excision Repair 108 3.93e-01 -0.047600 7.60e-01
Synthesis, secretion, and deacylation of Ghrelin 11 7.85e-01 -0.047500 9.42e-01
Glycogen storage diseases 13 7.67e-01 0.047500 9.34e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 5.05e-01 -0.047500 8.35e-01
Regulation of signaling by CBL 22 7.01e-01 -0.047300 9.19e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 8.55e-01 0.047200 9.61e-01
Aerobic respiration and respiratory electron transport 245 2.03e-01 0.047200 6.27e-01
G beta:gamma signalling through PI3Kgamma 22 7.02e-01 -0.047100 9.19e-01
Defects in cobalamin (B12) metabolism 13 7.69e-01 -0.047000 9.34e-01
WNT ligand biogenesis and trafficking 20 7.17e-01 -0.046800 9.21e-01
Activation of BAD and translocation to mitochondria 15 7.54e-01 0.046800 9.33e-01
Translesion synthesis by REV1 16 7.46e-01 -0.046800 9.32e-01
Host Interactions of HIV factors 118 3.82e-01 -0.046600 7.56e-01
Na+/Cl- dependent neurotransmitter transporters 8 8.20e-01 0.046600 9.55e-01
Glycosphingolipid metabolism 46 5.85e-01 -0.046600 8.70e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 5.62e-01 0.046500 8.57e-01
Phase II - Conjugation of compounds 70 5.02e-01 -0.046400 8.34e-01
Signaling by CSF3 (G-CSF) 29 6.66e-01 -0.046300 9.08e-01
Defective RIPK1-mediated regulated necrosis 7 8.33e-01 0.046000 9.59e-01
Cytosolic tRNA aminoacylation 24 6.98e-01 -0.045800 9.19e-01
SLC-mediated transmembrane transport 174 2.97e-01 0.045800 6.97e-01
Zinc transporters 12 7.84e-01 -0.045700 9.42e-01
RHOT2 GTPase cycle 7 8.36e-01 0.045100 9.59e-01
RET signaling 32 6.60e-01 -0.045000 9.06e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 7.48e-01 -0.045000 9.32e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 7.48e-01 -0.045000 9.32e-01
MTOR signalling 39 6.28e-01 -0.044900 8.87e-01
Post NMDA receptor activation events 64 5.36e-01 -0.044800 8.46e-01
Neurotransmitter clearance 5 8.64e-01 0.044300 9.64e-01
Insulin receptor recycling 24 7.08e-01 -0.044200 9.19e-01
DNA Replication 128 3.88e-01 -0.044100 7.59e-01
Factors involved in megakaryocyte development and platelet production 129 3.89e-01 0.044000 7.59e-01
ER to Golgi Anterograde Transport 145 3.61e-01 -0.043900 7.39e-01
Metabolism of cofactors 25 7.04e-01 0.043900 9.19e-01
Glucose metabolism 76 5.10e-01 -0.043700 8.35e-01
RUNX3 regulates CDKN1A transcription 7 8.41e-01 0.043700 9.59e-01
Negative regulators of DDX58/IFIH1 signaling 34 6.61e-01 -0.043500 9.06e-01
RAC1 GTPase cycle 172 3.27e-01 -0.043300 7.17e-01
Phosphorylation of CD3 and TCR zeta chains 27 6.98e-01 0.043200 9.19e-01
Pre-NOTCH Expression and Processing 63 5.54e-01 -0.043100 8.54e-01
Hh mutants are degraded by ERAD 42 6.29e-01 0.043100 8.88e-01
Regulation of endogenous retroelements 93 4.75e-01 -0.042800 8.20e-01
NRAGE signals death through JNK 52 5.94e-01 0.042700 8.74e-01
Signaling by NOTCH3 42 6.32e-01 0.042700 8.91e-01
Serine biosynthesis 8 8.35e-01 -0.042400 9.59e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 7.31e-01 0.042400 9.29e-01
Vesicle-mediated transport 665 6.24e-02 -0.042400 3.87e-01
HDMs demethylate histones 22 7.31e-01 -0.042300 9.29e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 8.28e-01 -0.041800 9.59e-01
MHC class II antigen presentation 113 4.44e-01 -0.041700 7.94e-01
Iron uptake and transport 52 6.05e-01 -0.041500 8.75e-01
Transcription of E2F targets under negative control by DREAM complex 19 7.54e-01 0.041500 9.33e-01
Fcgamma receptor (FCGR) dependent phagocytosis 148 3.84e-01 0.041400 7.57e-01
Transport to the Golgi and subsequent modification 171 3.52e-01 -0.041300 7.33e-01
Regulated Necrosis 56 5.93e-01 -0.041300 8.74e-01
Ketone body metabolism 8 8.40e-01 0.041100 9.59e-01
IRF3-mediated induction of type I IFN 12 8.06e-01 -0.041000 9.50e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 6.63e-01 -0.040900 9.07e-01
Citric acid cycle (TCA cycle) 34 6.80e-01 -0.040800 9.15e-01
Uptake and function of anthrax toxins 11 8.15e-01 -0.040700 9.55e-01
Lewis blood group biosynthesis 13 8.01e-01 0.040400 9.48e-01
Downstream TCR signaling 89 5.12e-01 -0.040200 8.36e-01
Axon guidance 459 1.40e-01 0.040200 5.30e-01
Transport of small molecules 556 1.06e-01 0.040100 4.76e-01
rRNA processing in the mitochondrion 24 7.34e-01 0.040100 9.31e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 7.29e-01 0.040000 9.29e-01
Uptake and function of diphtheria toxin 6 8.65e-01 0.040000 9.65e-01
Signaling by FGFR2 in disease 33 6.92e-01 -0.039800 9.19e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 6.27e-01 0.039700 8.87e-01
DNA Damage Recognition in GG-NER 38 6.72e-01 0.039700 9.13e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 6.81e-01 -0.039500 9.16e-01
Vitamin D (calciferol) metabolism 11 8.21e-01 0.039400 9.55e-01
Cellular response to chemical stress 179 3.64e-01 0.039300 7.42e-01
HCMV Infection 106 4.88e-01 -0.039000 8.27e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 5.96e-01 -0.039000 8.75e-01
Transcriptional regulation of pluripotent stem cells 19 7.69e-01 -0.039000 9.34e-01
HS-GAG biosynthesis 21 7.59e-01 0.038700 9.34e-01
TCR signaling 110 4.83e-01 -0.038700 8.23e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 7.60e-01 0.038500 9.34e-01
RNA Polymerase III Chain Elongation 18 7.78e-01 0.038500 9.38e-01
MicroRNA (miRNA) biogenesis 24 7.44e-01 0.038400 9.32e-01
Glycosphingolipid biosynthesis 15 7.97e-01 -0.038400 9.47e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 7.51e-01 -0.038200 9.32e-01
Thyroxine biosynthesis 5 8.82e-01 0.038200 9.75e-01
Autophagy 142 4.34e-01 -0.038000 7.83e-01
Activation of BH3-only proteins 30 7.20e-01 0.037800 9.22e-01
Metabolism of steroid hormones 21 7.65e-01 0.037700 9.34e-01
Cellular response to hypoxia 59 6.17e-01 0.037600 8.84e-01
Cell recruitment (pro-inflammatory response) 25 7.45e-01 0.037500 9.32e-01
Purinergic signaling in leishmaniasis infection 25 7.45e-01 0.037500 9.32e-01
Modulation by Mtb of host immune system 7 8.64e-01 -0.037500 9.64e-01
PLC beta mediated events 40 6.83e-01 -0.037300 9.16e-01
Tight junction interactions 17 7.90e-01 -0.037300 9.42e-01
Detoxification of Reactive Oxygen Species 30 7.25e-01 -0.037200 9.25e-01
Metabolism of steroids 123 4.78e-01 -0.037000 8.20e-01
STAT5 activation downstream of FLT3 ITD mutants 9 8.48e-01 -0.036900 9.60e-01
Activation of the phototransduction cascade 9 8.48e-01 0.036900 9.60e-01
Cytokine Signaling in Immune system 668 1.06e-01 -0.036700 4.76e-01
Signaling by NOTCH2 33 7.19e-01 0.036100 9.22e-01
MET activates RAS signaling 10 8.44e-01 -0.035900 9.60e-01
Oncogene Induced Senescence 33 7.22e-01 -0.035800 9.24e-01
Trafficking of GluR2-containing AMPA receptors 11 8.37e-01 0.035800 9.59e-01
mTORC1-mediated signalling 24 7.62e-01 -0.035700 9.34e-01
Formation of RNA Pol II elongation complex 56 6.45e-01 -0.035600 8.97e-01
RNA Polymerase II Transcription Elongation 56 6.45e-01 -0.035600 8.97e-01
Cleavage of the damaged pyrimidine 27 7.50e-01 -0.035500 9.32e-01
Depyrimidination 27 7.50e-01 -0.035500 9.32e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 7.50e-01 -0.035500 9.32e-01
Response of Mtb to phagocytosis 22 7.74e-01 0.035400 9.37e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 6.86e-01 0.035200 9.16e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 6.74e-01 0.035100 9.13e-01
Cyclin A:Cdk2-associated events at S phase entry 75 6.00e-01 0.035000 8.75e-01
Downregulation of ERBB2 signaling 24 7.66e-01 0.035000 9.34e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 8.48e-01 0.034900 9.60e-01
O-linked glycosylation of mucins 47 6.81e-01 -0.034700 9.15e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 7.89e-01 0.034600 9.42e-01
Diseases of programmed cell death 58 6.50e-01 -0.034500 8.99e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 8.75e-01 0.034400 9.72e-01
Thromboxane signalling through TP receptor 20 7.90e-01 -0.034400 9.42e-01
Regulation of FZD by ubiquitination 16 8.13e-01 0.034200 9.54e-01
Vpu mediated degradation of CD4 39 7.12e-01 0.034200 9.21e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 7.16e-01 -0.034200 9.21e-01
Striated Muscle Contraction 27 7.59e-01 0.034100 9.34e-01
RND2 GTPase cycle 36 7.24e-01 0.034000 9.25e-01
Cytosolic sensors of pathogen-associated DNA 63 6.42e-01 0.033900 8.97e-01
Signaling by FGFR 73 6.17e-01 0.033800 8.84e-01
RHOBTB3 ATPase cycle 10 8.53e-01 0.033700 9.61e-01
Signaling by Leptin 10 8.54e-01 0.033600 9.61e-01
RHOU GTPase cycle 40 7.13e-01 -0.033600 9.21e-01
Transport of bile salts and organic acids, metal ions and amine compounds 53 6.73e-01 -0.033500 9.13e-01
HDL remodeling 6 8.88e-01 -0.033300 9.77e-01
Mitotic G1 phase and G1/S transition 138 5.02e-01 -0.033100 8.34e-01
Fc epsilon receptor (FCERI) signaling 180 4.45e-01 0.033000 7.94e-01
Telomere C-strand (Lagging Strand) Synthesis 34 7.39e-01 -0.033000 9.32e-01
Negative regulation of NOTCH4 signaling 44 7.05e-01 0.032900 9.19e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 7.67e-01 -0.032900 9.34e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 8.99e-01 -0.032900 9.78e-01
Transcriptional regulation by RUNX1 170 4.59e-01 0.032900 8.06e-01
Nervous system development 478 2.19e-01 0.032800 6.42e-01
Interconversion of nucleotide di- and triphosphates 27 7.68e-01 0.032800 9.34e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 6.02e-01 -0.032700 8.75e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 6.02e-01 -0.032700 8.75e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 6.02e-01 -0.032700 8.75e-01
Sensory processing of sound by inner hair cells of the cochlea 54 6.78e-01 0.032700 9.15e-01
APC/C-mediated degradation of cell cycle proteins 75 6.26e-01 -0.032600 8.87e-01
Regulation of mitotic cell cycle 75 6.26e-01 -0.032600 8.87e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 8.52e-01 -0.032600 9.60e-01
RND3 GTPase cycle 35 7.40e-01 -0.032400 9.32e-01
RNA Polymerase I Promoter Clearance 64 6.54e-01 -0.032400 9.02e-01
RNA Polymerase I Transcription 64 6.54e-01 -0.032400 9.02e-01
Nicotinate metabolism 27 7.71e-01 -0.032400 9.36e-01
Translation of Structural Proteins 9694635 56 6.78e-01 -0.032100 9.15e-01
Pre-NOTCH Transcription and Translation 47 7.04e-01 -0.032000 9.19e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 8.06e-01 -0.031800 9.50e-01
Macroautophagy 128 5.36e-01 -0.031700 8.46e-01
Transcriptional regulation by RUNX2 89 6.06e-01 0.031600 8.76e-01
Regulation of Expression and Function of Type II Classical Cadherins 24 7.89e-01 0.031500 9.42e-01
Regulation of Homotypic Cell-Cell Adhesion 24 7.89e-01 0.031500 9.42e-01
ABC transporters in lipid homeostasis 14 8.38e-01 0.031500 9.59e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 9.03e-01 0.031500 9.78e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 7.07e-01 0.031300 9.19e-01
Assembly of the pre-replicative complex 87 6.14e-01 -0.031300 8.81e-01
TP53 Regulates Transcription of DNA Repair Genes 61 6.73e-01 -0.031200 9.13e-01
G1/S Transition 120 5.55e-01 -0.031200 8.54e-01
Signaling by GPCR 446 2.60e-01 0.031100 6.72e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 9.04e-01 -0.031100 9.78e-01
CaM pathway 28 7.76e-01 0.031000 9.38e-01
Calmodulin induced events 28 7.76e-01 0.031000 9.38e-01
Transport and synthesis of PAPS 6 8.96e-01 -0.030800 9.78e-01
Platelet homeostasis 69 6.59e-01 -0.030700 9.06e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 8.61e-01 0.030600 9.64e-01
Defective EXT2 causes exostoses 2 11 8.61e-01 0.030600 9.64e-01
Presynaptic depolarization and calcium channel opening 8 8.81e-01 0.030600 9.75e-01
SUMOylation of DNA methylation proteins 16 8.33e-01 0.030400 9.59e-01
Signaling by high-kinase activity BRAF mutants 33 7.63e-01 -0.030300 9.34e-01
Endogenous sterols 17 8.29e-01 -0.030200 9.59e-01
PTEN Regulation 127 5.57e-01 0.030200 8.54e-01
SHC-mediated cascade:FGFR1 13 8.51e-01 -0.030100 9.60e-01
Netrin mediated repulsion signals 5 9.07e-01 -0.030100 9.79e-01
GLI3 is processed to GLI3R by the proteasome 46 7.25e-01 -0.030000 9.25e-01
Scavenging by Class F Receptors 5 9.08e-01 -0.029900 9.79e-01
Centrosome maturation 81 6.42e-01 -0.029900 8.97e-01
Recruitment of mitotic centrosome proteins and complexes 81 6.42e-01 -0.029900 8.97e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.78e-01 -0.029800 8.66e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 8.24e-01 -0.029500 9.56e-01
Signal transduction by L1 20 8.20e-01 -0.029500 9.55e-01
Chaperonin-mediated protein folding 77 6.55e-01 -0.029500 9.02e-01
TNF signaling 56 7.04e-01 0.029400 9.19e-01
Mitochondrial tRNA aminoacylation 21 8.16e-01 0.029400 9.55e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 8.60e-01 0.029300 9.64e-01
STING mediated induction of host immune responses 15 8.44e-01 -0.029300 9.60e-01
FOXO-mediated transcription 58 7.04e-01 -0.028800 9.19e-01
Synthesis of substrates in N-glycan biosythesis 59 7.02e-01 0.028800 9.19e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 7.07e-01 -0.028800 9.19e-01
Sensory processing of sound 58 7.05e-01 0.028700 9.19e-01
RHOQ GTPase cycle 54 7.15e-01 -0.028700 9.21e-01
RNA Polymerase I Transcription Initiation 47 7.33e-01 -0.028700 9.30e-01
Formation of WDR5-containing histone-modifying complexes 42 7.48e-01 -0.028700 9.32e-01
Post-translational modification: synthesis of GPI-anchored proteins 60 7.01e-01 -0.028600 9.19e-01
Inactivation of CSF3 (G-CSF) signaling 24 8.10e-01 0.028300 9.54e-01
Rab regulation of trafficking 121 5.90e-01 -0.028300 8.74e-01
Regulation of ornithine decarboxylase (ODC) 38 7.63e-01 0.028300 9.34e-01
RHOB GTPase cycle 64 6.98e-01 -0.028100 9.19e-01
Interleukin-1 family signaling 127 5.87e-01 -0.027900 8.72e-01
Signaling by NTRK1 (TRKA) 102 6.27e-01 -0.027800 8.87e-01
CDH11 homotypic and heterotypic interactions 5 9.15e-01 0.027700 9.82e-01
ABC-family proteins mediated transport 81 6.66e-01 0.027700 9.08e-01
ER-Phagosome pathway 75 6.80e-01 -0.027500 9.15e-01
Translation initiation complex formation 58 7.17e-01 0.027500 9.21e-01
Sodium/Proton exchangers 7 9.00e-01 0.027500 9.78e-01
CDC42 GTPase cycle 140 5.81e-01 -0.027000 8.67e-01
Cell-cell junction organization 57 7.25e-01 0.027000 9.25e-01
EGFR interacts with phospholipase C-gamma 6 9.09e-01 -0.026900 9.79e-01
Metabolism of amine-derived hormones 10 8.83e-01 0.026900 9.75e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 8.23e-01 0.026900 9.56e-01
Termination of translesion DNA synthesis 32 7.92e-01 -0.026900 9.44e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 7.32e-01 -0.026500 9.29e-01
Regulation of Apoptosis 40 7.74e-01 0.026200 9.38e-01
Mitochondrial protein degradation 96 6.58e-01 -0.026100 9.06e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 7.43e-01 0.026000 9.32e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 7.43e-01 0.026000 9.32e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 7.43e-01 0.026000 9.32e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 7.43e-01 0.026000 9.32e-01
Signaling by NOTCH1 in Cancer 53 7.43e-01 0.026000 9.32e-01
Hh mutants abrogate ligand secretion 43 7.69e-01 0.025900 9.34e-01
Disease 1623 8.25e-02 -0.025900 4.22e-01
Switching of origins to a post-replicative state 79 6.91e-01 -0.025900 9.19e-01
RNA Polymerase III Abortive And Retractive Initiation 40 7.79e-01 -0.025600 9.38e-01
RNA Polymerase III Transcription 40 7.79e-01 -0.025600 9.38e-01
The phototransduction cascade 27 8.19e-01 -0.025500 9.55e-01
Base-Excision Repair, AP Site Formation 29 8.13e-01 0.025400 9.54e-01
Diseases associated with the TLR signaling cascade 29 8.14e-01 -0.025300 9.54e-01
Diseases of Immune System 29 8.14e-01 -0.025300 9.54e-01
CLEC7A (Dectin-1) signaling 86 6.86e-01 -0.025200 9.16e-01
Recycling pathway of L1 40 7.83e-01 0.025200 9.42e-01
MET activates PTK2 signaling 23 8.35e-01 -0.025100 9.59e-01
Amine ligand-binding receptors 10 8.91e-01 -0.025100 9.77e-01
ERKs are inactivated 13 8.76e-01 -0.025000 9.72e-01
Transcriptional regulation by RUNX3 80 6.99e-01 0.025000 9.19e-01
Plasma lipoprotein assembly 10 8.91e-01 0.024900 9.77e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 7.41e-01 0.024900 9.32e-01
Ribosomal scanning and start codon recognition 58 7.44e-01 0.024800 9.32e-01
TAK1-dependent IKK and NF-kappa-B activation 43 7.78e-01 0.024800 9.38e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 8.21e-01 0.024700 9.55e-01
KEAP1-NFE2L2 pathway 107 6.64e-01 0.024300 9.07e-01
Amino acid transport across the plasma membrane 25 8.34e-01 -0.024200 9.59e-01
Neuronal System 270 4.93e-01 0.024200 8.28e-01
SHC-mediated cascade:FGFR2 13 8.80e-01 -0.024100 9.75e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.35e-01 -0.024100 9.59e-01
FGFR2c ligand binding and activation 5 9.26e-01 -0.024000 9.83e-01
VEGFR2 mediated vascular permeability 25 8.38e-01 0.023600 9.59e-01
Metabolism of water-soluble vitamins and cofactors 116 6.64e-01 0.023300 9.07e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 7.57e-01 0.023300 9.34e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 8.47e-01 -0.023200 9.60e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 8.47e-01 -0.023200 9.60e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 8.38e-01 -0.023200 9.59e-01
Activation of kainate receptors upon glutamate binding 26 8.38e-01 -0.023100 9.59e-01
Influenza Infection 153 6.23e-01 0.023000 8.87e-01
Purine ribonucleoside monophosphate biosynthesis 9 9.05e-01 -0.022900 9.79e-01
Signaling by NTRKs 116 6.75e-01 -0.022500 9.13e-01
Chromosome Maintenance 103 6.93e-01 -0.022500 9.19e-01
Immune System 1841 1.09e-01 -0.022500 4.82e-01
EPH-ephrin mediated repulsion of cells 43 8.00e-01 -0.022300 9.48e-01
Surfactant metabolism 20 8.64e-01 -0.022100 9.64e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 9.25e-01 -0.022100 9.83e-01
Degradation of AXIN 42 8.05e-01 0.022000 9.50e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 8.62e-01 0.022000 9.64e-01
Positive epigenetic regulation of rRNA expression 60 7.69e-01 -0.022000 9.34e-01
p38MAPK events 13 8.92e-01 0.021800 9.77e-01
Ca-dependent events 30 8.37e-01 -0.021700 9.59e-01
Respiratory syncytial virus (RSV) attachment and entry 19 8.70e-01 -0.021700 9.69e-01
Base Excision Repair 57 7.78e-01 0.021600 9.38e-01
Lysosome Vesicle Biogenesis 32 8.33e-01 -0.021500 9.59e-01
Mitotic G2-G2/M phases 179 6.21e-01 -0.021400 8.86e-01
Dectin-2 family 19 8.73e-01 0.021200 9.71e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.49e-01 -0.021200 9.60e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.49e-01 -0.021200 9.60e-01
Proteasome assembly 51 7.94e-01 0.021100 9.45e-01
N-Glycan antennae elongation 13 8.96e-01 0.021000 9.78e-01
Adaptive Immune System 771 3.21e-01 -0.021000 7.15e-01
Phospholipase C-mediated cascade; FGFR3 5 9.36e-01 0.020800 9.83e-01
Chromatin modifying enzymes 214 6.03e-01 -0.020600 8.75e-01
Chromatin organization 214 6.03e-01 -0.020600 8.75e-01
Transcriptional Regulation by VENTX 39 8.26e-01 -0.020300 9.58e-01
Glycine degradation 7 9.27e-01 0.020100 9.83e-01
STAT3 nuclear events downstream of ALK signaling 11 9.08e-01 0.020100 9.79e-01
G2/M Transition 177 6.45e-01 -0.020100 8.97e-01
Cardiogenesis 14 8.97e-01 0.020000 9.78e-01
RUNX3 Regulates Immune Response and Cell Migration 5 9.38e-01 0.020000 9.83e-01
Signaling by LTK 10 9.14e-01 -0.019700 9.82e-01
SCF(Skp2)-mediated degradation of p27/p21 50 8.11e-01 0.019600 9.54e-01
GPCR downstream signalling 399 5.02e-01 0.019600 8.34e-01
SARS-CoV-1 Infection 137 6.92e-01 -0.019600 9.19e-01
Degradation of GLI2 by the proteasome 45 8.21e-01 -0.019500 9.55e-01
tRNA Aminoacylation 42 8.27e-01 -0.019500 9.58e-01
Hedgehog ‘off’ state 92 7.51e-01 0.019200 9.32e-01
Antigen processing-Cross presentation 89 7.55e-01 -0.019100 9.34e-01
Aquaporin-mediated transport 38 8.38e-01 -0.019100 9.59e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 9.02e-01 -0.019000 9.78e-01
Signaling by NTRK3 (TRKC) 15 8.99e-01 -0.019000 9.78e-01
Protein folding 83 7.66e-01 -0.018900 9.34e-01
Orc1 removal from chromatin 58 8.04e-01 0.018800 9.50e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 8.87e-01 0.018800 9.77e-01
Metabolism 1827 1.84e-01 0.018700 6.01e-01
Miscellaneous transport and binding events 20 8.85e-01 -0.018700 9.76e-01
Synthesis of PE 12 9.11e-01 0.018600 9.80e-01
Recycling of bile acids and salts 10 9.19e-01 -0.018500 9.83e-01
Signaling by RNF43 mutants 7 9.33e-01 0.018400 9.83e-01
Budding and maturation of HIV virion 26 8.71e-01 0.018300 9.70e-01
Recycling of eIF2:GDP 8 9.30e-01 -0.018000 9.83e-01
Negative regulation of MAPK pathway 42 8.40e-01 -0.018000 9.59e-01
Muscle contraction 145 7.10e-01 -0.017900 9.21e-01
Ion homeostasis 42 8.42e-01 0.017800 9.59e-01
Adipogenesis 95 7.66e-01 0.017700 9.34e-01
Removal of the Flap Intermediate 14 9.09e-01 -0.017700 9.79e-01
Regulation of RUNX2 expression and activity 54 8.22e-01 -0.017700 9.56e-01
Reactions specific to the complex N-glycan synthesis pathway 7 9.36e-01 -0.017600 9.83e-01
L1CAM interactions 101 7.60e-01 0.017600 9.34e-01
Nuclear Receptor transcription pathway 38 8.51e-01 -0.017600 9.60e-01
Infectious disease 958 3.57e-01 -0.017600 7.34e-01
PKA-mediated phosphorylation of CREB 17 9.00e-01 0.017500 9.78e-01
Selective autophagy 77 7.91e-01 -0.017400 9.43e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 7.97e-01 -0.017300 9.47e-01
Coenzyme A biosynthesis 7 9.37e-01 -0.017200 9.83e-01
Telomere Maintenance 78 7.93e-01 0.017200 9.44e-01
Regulation of RAS by GAPs 55 8.27e-01 0.017000 9.58e-01
Carnitine shuttle 12 9.19e-01 0.017000 9.83e-01
FGFR1c ligand binding and activation 8 9.34e-01 0.017000 9.83e-01
Developmental Biology 924 3.82e-01 0.017000 7.56e-01
Regulation of gene expression in beta cells 8 9.34e-01 -0.017000 9.83e-01
SARS-CoV-1-host interactions 94 7.77e-01 0.016900 9.38e-01
Metabolism of nucleotides 85 7.88e-01 -0.016900 9.42e-01
Lagging Strand Synthesis 20 8.97e-01 -0.016800 9.78e-01
EGFR downregulation 26 8.82e-01 -0.016800 9.75e-01
G alpha (z) signalling events 36 8.62e-01 0.016700 9.64e-01
HDL assembly 6 9.43e-01 -0.016700 9.83e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 8.95e-01 0.016700 9.78e-01
Neurodegenerative Diseases 21 8.95e-01 0.016700 9.78e-01
Interleukin-20 family signaling 17 9.05e-01 0.016700 9.79e-01
Regulation of NF-kappa B signaling 18 9.03e-01 0.016600 9.78e-01
Attachment of GPI anchor to uPAR 7 9.39e-01 0.016600 9.83e-01
Stabilization of p53 43 8.51e-01 0.016500 9.60e-01
Cell death signalling via NRAGE, NRIF and NADE 69 8.14e-01 -0.016400 9.54e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 8.51e-01 0.016400 9.60e-01
SARS-CoV-1 activates/modulates innate immune responses 40 8.64e-01 -0.015600 9.64e-01
Hedgehog ligand biogenesis 47 8.53e-01 0.015600 9.61e-01
Hedgehog ‘on’ state 66 8.27e-01 0.015600 9.58e-01
Cyclin E associated events during G1/S transition 73 8.18e-01 0.015600 9.55e-01
Pyroptosis 25 8.94e-01 -0.015400 9.78e-01
Regulation of CDH19 Expression and Function 6 9.48e-01 0.015300 9.83e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 9.13e-01 -0.015300 9.81e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 8.47e-01 0.015200 9.60e-01
RNA Polymerase III Transcription Initiation 36 8.75e-01 -0.015100 9.72e-01
Viral Infection Pathways 775 4.75e-01 -0.015100 8.20e-01
NIK–>noncanonical NF-kB signaling 46 8.60e-01 0.015100 9.64e-01
Dermatan sulfate biosynthesis 6 9.49e-01 -0.015000 9.83e-01
Integrin signaling 22 9.04e-01 -0.014900 9.78e-01
Processive synthesis on the lagging strand 15 9.21e-01 0.014900 9.83e-01
Cellular responses to mechanical stimuli 82 8.19e-01 -0.014600 9.55e-01
Response of endothelial cells to shear stress 82 8.19e-01 -0.014600 9.55e-01
Organic cation transport 8 9.43e-01 -0.014500 9.83e-01
Organic cation/anion/zwitterion transport 8 9.43e-01 -0.014500 9.83e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 8.97e-01 0.014400 9.78e-01
Release of apoptotic factors from the mitochondria 6 9.52e-01 0.014100 9.83e-01
Post-translational protein phosphorylation 67 8.42e-01 0.014100 9.59e-01
Nuclear Events (kinase and transcription factor activation) 54 8.58e-01 -0.014100 9.64e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 9.18e-01 0.014100 9.83e-01
Transmission across Chemical Synapses 183 7.45e-01 -0.014000 9.32e-01
Hemostasis 558 5.74e-01 0.013900 8.65e-01
GPER1 signaling 38 8.84e-01 -0.013700 9.75e-01
Inhibition of DNA recombination at telomere 33 8.92e-01 -0.013700 9.77e-01
Signaling by WNT in cancer 30 8.97e-01 -0.013700 9.78e-01
Activation of G protein gated Potassium channels 19 9.19e-01 0.013500 9.83e-01
G protein gated Potassium channels 19 9.19e-01 0.013500 9.83e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 9.19e-01 0.013500 9.83e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 8.92e-01 0.013500 9.77e-01
RHOA GTPase cycle 138 7.86e-01 -0.013400 9.42e-01
Unfolded Protein Response (UPR) 85 8.31e-01 -0.013400 9.59e-01
Interleukin-1 signaling 99 8.18e-01 -0.013400 9.55e-01
Metabolism of polyamines 46 8.76e-01 0.013300 9.72e-01
HDACs deacetylate histones 45 8.77e-01 0.013300 9.72e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 8.92e-01 0.013300 9.77e-01
ABC transporter disorders 60 8.59e-01 -0.013200 9.64e-01
Biological oxidations 143 7.86e-01 0.013100 9.42e-01
G1/S-Specific Transcription 29 9.03e-01 0.013000 9.78e-01
Protein methylation 15 9.31e-01 0.013000 9.83e-01
Regulation of PTEN stability and activity 55 8.68e-01 0.013000 9.67e-01
Ovarian tumor domain proteases 37 8.92e-01 -0.012900 9.77e-01
Cytochrome P450 - arranged by substrate type 39 8.90e-01 -0.012800 9.77e-01
Recruitment of NuMA to mitotic centrosomes 88 8.36e-01 -0.012800 9.59e-01
Lysine catabolism 11 9.41e-01 -0.012800 9.83e-01
Transcriptional regulation of white adipocyte differentiation 77 8.51e-01 0.012400 9.60e-01
Fatty acid metabolism 157 7.89e-01 -0.012400 9.42e-01
Ephrin signaling 18 9.29e-01 -0.012200 9.83e-01
GABA receptor activation 36 9.00e-01 -0.012100 9.78e-01
CD28 dependent PI3K/Akt signaling 22 9.25e-01 0.011600 9.83e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 9.58e-01 0.011500 9.84e-01
Signal Transduction 2051 3.89e-01 -0.011500 7.59e-01
TRAF6 mediated IRF7 activation 15 9.39e-01 0.011500 9.83e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 9.33e-01 -0.011400 9.83e-01
MAPK family signaling cascades 263 7.50e-01 0.011400 9.32e-01
Synthesis of DNA 108 8.42e-01 -0.011100 9.59e-01
Signaling by NOTCH1 66 8.77e-01 0.011000 9.72e-01
COPI-mediated anterograde transport 92 8.55e-01 -0.011000 9.61e-01
Cardiac conduction 89 8.60e-01 -0.010800 9.64e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 9.20e-01 -0.010700 9.83e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 9.61e-01 0.010700 9.85e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 8.83e-01 0.010700 9.75e-01
Myoclonic epilepsy of Lafora 8 9.59e-01 0.010600 9.84e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 9.50e-01 0.010500 9.83e-01
Innate Immune System 970 5.80e-01 -0.010500 8.66e-01
CS/DS degradation 9 9.57e-01 0.010400 9.84e-01
Aflatoxin activation and detoxification 14 9.47e-01 -0.010300 9.83e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 9.40e-01 0.010300 9.83e-01
Regulation of TP53 Activity through Methylation 19 9.38e-01 0.010300 9.83e-01
Translation 292 7.64e-01 0.010200 9.34e-01
RNA Polymerase III Transcription Termination 22 9.38e-01 0.009610 9.83e-01
Regulation of APC/C activators between G1/S and early anaphase 68 8.91e-01 -0.009580 9.77e-01
Activation of NF-kappaB in B cells 54 9.03e-01 -0.009550 9.78e-01
MAP2K and MAPK activation 36 9.22e-01 -0.009380 9.83e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.43e-01 -0.009190 9.83e-01
Cellular responses to stimuli 778 6.64e-01 -0.009160 9.07e-01
G0 and Early G1 27 9.35e-01 -0.009120 9.83e-01
RHOT1 GTPase cycle 5 9.72e-01 -0.008950 9.89e-01
Inactivation of CDC42 and RAC1 7 9.68e-01 -0.008850 9.89e-01
Interleukin-15 signaling 14 9.55e-01 0.008650 9.83e-01
PCNA-Dependent Long Patch Base Excision Repair 21 9.46e-01 0.008530 9.83e-01
Signaling by FGFR2 61 9.10e-01 0.008410 9.79e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 9.54e-01 -0.008360 9.83e-01
Glycosphingolipid transport 7 9.69e-01 0.008360 9.89e-01
Polymerase switching on the C-strand of the telomere 26 9.42e-01 0.008260 9.83e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 9.12e-01 -0.008240 9.81e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 9.75e-01 0.008170 9.89e-01
Regulation of MITF-M-dependent genes involved in pigmentation 38 9.33e-01 0.007890 9.83e-01
Costimulation by the CD28 family 74 9.08e-01 -0.007740 9.79e-01
PIP3 activates AKT signaling 234 8.39e-01 -0.007700 9.59e-01
SUMOylation of transcription factors 16 9.58e-01 -0.007620 9.84e-01
Extension of Telomeres 51 9.25e-01 0.007620 9.83e-01
Cleavage of the damaged purine 22 9.51e-01 -0.007610 9.83e-01
Depurination 22 9.51e-01 -0.007610 9.83e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 9.51e-01 -0.007610 9.83e-01
Integration of energy metabolism 88 9.02e-01 -0.007570 9.78e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 9.43e-01 0.007520 9.83e-01
CDK-mediated phosphorylation and removal of Cdc6 60 9.20e-01 0.007510 9.83e-01
Cellular responses to stress 697 7.39e-01 -0.007410 9.32e-01
Evasion by RSV of host interferon responses 20 9.55e-01 -0.007360 9.83e-01
Regulation of CDH11 Expression and Function 22 9.53e-01 0.007220 9.83e-01
Diseases associated with N-glycosylation of proteins 20 9.56e-01 -0.007190 9.83e-01
Inactivation, recovery and regulation of the phototransduction cascade 26 9.50e-01 -0.007120 9.83e-01
Polo-like kinase mediated events 16 9.62e-01 0.006970 9.85e-01
APC/C:Cdc20 mediated degradation of Securin 55 9.29e-01 0.006940 9.83e-01
p53-Dependent G1 DNA Damage Response 52 9.32e-01 0.006860 9.83e-01
p53-Dependent G1/S DNA damage checkpoint 52 9.32e-01 0.006860 9.83e-01
SARS-CoV Infections 434 8.08e-01 -0.006790 9.53e-01
Activation of gene expression by SREBF (SREBP) 42 9.40e-01 -0.006720 9.83e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 76 9.21e-01 0.006580 9.83e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 9.24e-01 0.006320 9.83e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 9.45e-01 -0.006110 9.83e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 9.50e-01 0.006060 9.83e-01
Maturation of spike protein 9694548 36 9.50e-01 0.006060 9.83e-01
Defective CFTR causes cystic fibrosis 47 9.45e-01 -0.005800 9.83e-01
PI3K/AKT Signaling in Cancer 84 9.27e-01 0.005770 9.83e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 9.59e-01 -0.005760 9.84e-01
DAG and IP3 signaling 34 9.54e-01 -0.005710 9.83e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 9.26e-01 0.005700 9.83e-01
Neutrophil degranulation 456 8.35e-01 0.005690 9.59e-01
GP1b-IX-V activation signalling 11 9.74e-01 0.005610 9.89e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 9.72e-01 0.005410 9.89e-01
G alpha (12/13) signalling events 68 9.39e-01 -0.005370 9.83e-01
Translesion Synthesis by POLH 18 9.70e-01 0.005160 9.89e-01
Signaling by Hedgehog 121 9.26e-01 0.004870 9.83e-01
Late SARS-CoV-2 Infection Events 64 9.46e-01 0.004860 9.83e-01
G alpha (q) signalling events 139 9.21e-01 0.004850 9.83e-01
Telomere Extension By Telomerase 23 9.68e-01 0.004780 9.89e-01
Diseases associated with glycosaminoglycan metabolism 26 9.66e-01 -0.004780 9.88e-01
Degradation of GLI1 by the proteasome 46 9.55e-01 -0.004760 9.83e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 9.73e-01 0.004540 9.89e-01
tRNA modification in the mitochondrion 9 9.81e-01 0.004510 9.93e-01
Azathioprine ADME 20 9.73e-01 0.004450 9.89e-01
Glucagon signaling in metabolic regulation 26 9.69e-01 0.004370 9.89e-01
Signaling by Receptor Tyrosine Kinases 443 8.78e-01 -0.004270 9.72e-01
Regulation of IFNA/IFNB signaling 12 9.80e-01 0.004260 9.92e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 9.69e-01 -0.004260 9.89e-01
Signaling by Interleukins 390 8.88e-01 0.004170 9.77e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 9.79e-01 -0.004160 9.92e-01
Infection with Mycobacterium tuberculosis 26 9.71e-01 -0.004070 9.89e-01
Acetylcholine binding and downstream events 5 9.88e-01 -0.003830 9.96e-01
Postsynaptic nicotinic acetylcholine receptors 5 9.88e-01 -0.003830 9.96e-01
G1/S DNA Damage Checkpoints 54 9.61e-01 0.003830 9.85e-01
Intracellular signaling by second messengers 267 9.16e-01 -0.003740 9.83e-01
Keratan sulfate biosynthesis 20 9.79e-01 0.003470 9.92e-01
Signaling by WNT 240 9.27e-01 0.003450 9.83e-01
Sensory Perception 194 9.36e-01 -0.003330 9.83e-01
Transferrin endocytosis and recycling 26 9.77e-01 0.003220 9.91e-01
Death Receptor Signaling 145 9.52e-01 -0.002900 9.83e-01
p75 NTR receptor-mediated signalling 89 9.64e-01 0.002800 9.86e-01
The NLRP3 inflammasome 16 9.85e-01 0.002720 9.95e-01
Protein localization 157 9.53e-01 -0.002710 9.83e-01
Acyl chain remodeling of CL 5 9.92e-01 -0.002550 9.98e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 9.73e-01 -0.002470 9.89e-01
Interleukin-6 family signaling 20 9.86e-01 0.002320 9.95e-01
Scavenging by Class A Receptors 12 9.90e-01 -0.002170 9.97e-01
Signaling by NOTCH 173 9.61e-01 0.002140 9.85e-01
Cell-Cell communication 110 9.70e-01 0.002050 9.89e-01
Pexophagy 10 9.93e-01 0.001500 9.99e-01
Activation of HOX genes during differentiation 70 9.84e-01 -0.001390 9.95e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 9.84e-01 -0.001390 9.95e-01
Chaperone Mediated Autophagy 20 9.91e-01 -0.001390 9.98e-01
CHL1 interactions 8 9.95e-01 -0.001280 9.99e-01
Protein repair 6 9.96e-01 -0.001280 9.99e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 9.86e-01 0.001240 9.95e-01
Beta-catenin independent WNT signaling 126 9.85e-01 0.000957 9.95e-01
Uptake and actions of bacterial toxins 27 9.94e-01 -0.000833 9.99e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 9.96e-01 0.000375 9.99e-01
Long-term potentiation 18 9.99e-01 0.000229 9.99e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 9.99e-01 0.000219 9.99e-01
Synthesis of IP3 and IP4 in the cytosol 22 9.99e-01 -0.000216 9.99e-01
Signaling by NOTCH4 68 9.98e-01 0.000194 9.99e-01
G alpha (i) signalling events 196 9.96e-01 0.000187 9.99e-01
Leading Strand Synthesis 14 9.99e-01 0.000111 9.99e-01
Polymerase switching 14 9.99e-01 0.000111 9.99e-01


Detailed Gene set reports



Establishment of Sister Chromatid Cohesion
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 6.74e-05
s.dist -0.694
p.adjustANOVA 0.0108


Top enriched genes
Top 20 genes
GeneID Gene Rank
ESCO1 -10626
STAG1 -10448
STAG2 -9820
SMC3 -9444
WAPL -8857
PDS5A -8674
PDS5B -8663
RAD21 -7420
ESCO2 -6370
SMC1A -4921
CDCA5 3559

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All member genes
GeneID Gene Rank
ESCO1 -10626
STAG1 -10448
STAG2 -9820
SMC3 -9444
WAPL -8857
PDS5A -8674
PDS5B -8663
RAD21 -7420
ESCO2 -6370
SMC1A -4921
CDCA5 3559


Diseases of Mismatch Repair (MMR)
set Diseases of Mismatch Repair (MMR)
setSize 5
pANOVA 0.00812
s.dist -0.684
p.adjustANOVA 0.134


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH3 -8726
MLH1 -8555
MSH2 -7105
PMS2 -6612
MSH6 -5579

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All member genes
GeneID Gene Rank
MSH3 -8726
MLH1 -8555
MSH2 -7105
PMS2 -6612
MSH6 -5579


Negative regulation of TCF-dependent signaling by DVL-interacting proteins
set Negative regulation of TCF-dependent signaling by DVL-interacting proteins
setSize 5
pANOVA 0.0082
s.dist 0.683
p.adjustANOVA 0.134


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL1 10697
CCDC88C 10275
DVL3 9465
DVL2 7398
CXXC4 271

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All member genes
GeneID Gene Rank
DVL1 10697
CCDC88C 10275
DVL3 9465
DVL2 7398
CXXC4 271


Cohesin Loading onto Chromatin
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 0.000211
s.dist -0.677
p.adjustANOVA 0.0272


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAG1 -10448
STAG2 -9820
SMC3 -9444
NIPBL -9433
WAPL -8857
PDS5A -8674
PDS5B -8663
RAD21 -7420
SMC1A -4921
MAU2 5312

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 -10448
STAG2 -9820
SMC3 -9444
NIPBL -9433
WAPL -8857
PDS5A -8674
PDS5B -8663
RAD21 -7420
SMC1A -4921
MAU2 5312


SUMO is proteolytically processed
set SUMO is proteolytically processed
setSize 6
pANOVA 0.0042
s.dist -0.675
p.adjustANOVA 0.0974


Top enriched genes
Top 20 genes
GeneID Gene Rank
SENP2 -10768
SUMO1 -10213
SENP1 -8965
SENP5 -8323
SUMO2 -6318
SUMO3 1265

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All member genes
GeneID Gene Rank
SENP2 -10768
SUMO1 -10213
SENP1 -8965
SENP5 -8323
SUMO2 -6318
SUMO3 1265


MET activates PI3K/AKT signaling
set MET activates PI3K/AKT signaling
setSize 5
pANOVA 0.0137
s.dist -0.637
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIK3CA -10063
GAB1 -8893
PIK3R1 -7814
GRB2 -4899
HGF -2346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3CA -10063
GAB1 -8893
PIK3R1 -7814
GRB2 -4899
HGF -2346


Synthesis of PIPs at the late endosome membrane
set Synthesis of PIPs at the late endosome membrane
setSize 11
pANOVA 0.000348
s.dist -0.623
p.adjustANOVA 0.0318


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIK3C3 -10600
PIK3C2A -10236
MTMR2 -10100
MTM1 -9713
PIKFYVE -8792
MTMR9 -8367
MTMR7 -7393
FIG4 -7229
PIK3R4 -5562
MTMR4 -3038
VAC14 7903

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3C3 -10600
PIK3C2A -10236
MTMR2 -10100
MTM1 -9713
PIKFYVE -8792
MTMR9 -8367
MTMR7 -7393
FIG4 -7229
PIK3R4 -5562
MTMR4 -3038
VAC14 7903


Phosphate bond hydrolysis by NTPDase proteins
set Phosphate bond hydrolysis by NTPDase proteins
setSize 5
pANOVA 0.0161
s.dist -0.621
p.adjustANOVA 0.197


Top enriched genes
Top 20 genes
GeneID Gene Rank
ENTPD5 -9474
ENTPD7 -7365
ENTPD4 -6031
ENTPD1 -5606
ENTPD6 -4703

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All member genes
GeneID Gene Rank
ENTPD5 -9474
ENTPD7 -7365
ENTPD4 -6031
ENTPD1 -5606
ENTPD6 -4703


Synthesis of PIPs at the early endosome membrane
set Synthesis of PIPs at the early endosome membrane
setSize 16
pANOVA 3e-05
s.dist -0.603
p.adjustANOVA 0.00827


Top enriched genes
Top 20 genes
GeneID Gene Rank
PIK3C3 -10600
PIK3C2A -10236
MTMR10 -10172
MTMR2 -10100
MTMR12 -9832
MTM1 -9713
PIKFYVE -8792
PI4K2B -8270
FIG4 -7229
INPP5F -6666
PI4K2A -6114
PIK3R4 -5562
MTMR4 -3038
INPP4A -2399
INPP4B -2008
VAC14 7903

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3C3 -10600
PIK3C2A -10236
MTMR10 -10172
MTMR2 -10100
MTMR12 -9832
MTM1 -9713
PIKFYVE -8792
PI4K2B -8270
FIG4 -7229
INPP5F -6666
PI4K2A -6114
PIK3R4 -5562
MTMR4 -3038
INPP4A -2399
INPP4B -2008
VAC14 7903


Activation of caspases through apoptosome-mediated cleavage
set Activation of caspases through apoptosome-mediated cleavage
setSize 6
pANOVA 0.0135
s.dist -0.583
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348


Synthesis of wybutosine at G37 of tRNA(Phe)
set Synthesis of wybutosine at G37 of tRNA(Phe)
setSize 6
pANOVA 0.0137
s.dist -0.581
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
TYW3 -10129
TYW5 -9667
TYW1 -9000
TRMT5 -5923
LCMT2 -2577
TRMT12 139

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All member genes
GeneID Gene Rank
TYW3 -10129
TYW5 -9667
TYW1 -9000
TRMT5 -5923
LCMT2 -2577
TRMT12 139


Diseases of Base Excision Repair
set Diseases of Base Excision Repair
setSize 5
pANOVA 0.028
s.dist 0.567
p.adjustANOVA 0.277


Top enriched genes
Top 20 genes
GeneID Gene Rank
NEIL1 10216
MUTYH 10137
OGG1 8592
NTHL1 7240
NEIL3 -4378

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All member genes
GeneID Gene Rank
NEIL1 10216
MUTYH 10137
OGG1 8592
NTHL1 7240
NEIL3 -4378


Formation of the active cofactor, UDP-glucuronate
set Formation of the active cofactor, UDP-glucuronate
setSize 5
pANOVA 0.0338
s.dist -0.548
p.adjustANOVA 0.301


Top enriched genes
Top 20 genes
GeneID Gene Rank
UGP2 -7352
UGDH -7146
SLC35D1 -5636
UXS1 -4760
SLC35D2 -4271

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UGP2 -7352
UGDH -7146
SLC35D1 -5636
UXS1 -4760
SLC35D2 -4271


Small interfering RNA (siRNA) biogenesis
set Small interfering RNA (siRNA) biogenesis
setSize 9
pANOVA 0.0045
s.dist -0.547
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
TSN -10339
PRKRA -10298
AGO4 -9929
TSNAX -9904
AGO3 -9243
DICER1 -8968
AGO1 -2636
AGO2 307
TARBP2 8641

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TSN -10339
PRKRA -10298
AGO4 -9929
TSNAX -9904
AGO3 -9243
DICER1 -8968
AGO1 -2636
AGO2 307
TARBP2 8641


Erythrocytes take up oxygen and release carbon dioxide
set Erythrocytes take up oxygen and release carbon dioxide
setSize 7
pANOVA 0.0128
s.dist 0.543
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC4A1 11044
CA1 10866
HBA1 10842
HBB 10225
CA4 3383
CA2 -1279
AQP1 -2421

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC4A1 11044
CA1 10866
HBA1 10842
HBB 10225
CA4 3383
CA2 -1279
AQP1 -2421


PI-3K cascade:FGFR3
set PI-3K cascade:FGFR3
setSize 10
pANOVA 0.00325
s.dist -0.537
p.adjustANOVA 0.0869


Top enriched genes
Top 20 genes
GeneID Gene Rank
FRS2 -10239
PIK3CA -10063
PTPN11 -9044
GAB1 -8893
PIK3R1 -7814
FGF23 -7573
GRB2 -4899
FGF2 -3453
FGF9 -273
FGF17 5079

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FRS2 -10239
PIK3CA -10063
PTPN11 -9044
GAB1 -8893
PIK3R1 -7814
FGF23 -7573
GRB2 -4899
FGF2 -3453
FGF9 -273
FGF17 5079


Synthesis of GDP-mannose
set Synthesis of GDP-mannose
setSize 6
pANOVA 0.0229
s.dist 0.536
p.adjustANOVA 0.251


Top enriched genes
Top 20 genes
GeneID Gene Rank
PMM2 10682
PMM1 6269
MPI 5618
GMPPB 5547
GMPPA 4732
HK1 3284

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All member genes
GeneID Gene Rank
PMM2 10682
PMM1 6269
MPI 5618
GMPPB 5547
GMPPA 4732
HK1 3284


ALK mutants bind TKIs
set ALK mutants bind TKIs
setSize 11
pANOVA 0.00274
s.dist -0.522
p.adjustANOVA 0.0798


Top enriched genes
Top 20 genes
GeneID Gene Rank
PRKAR1A -9112
STRN -8623
EIF2AK3 -8170
CLTC -8168
NPM1 -6866
EML4 -6208
BCL11A -6104
BIRC6 -4462
PPM1B -3272
HIP1 -1416
FN1 1425

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAR1A -9112
STRN -8623
EIF2AK3 -8170
CLTC -8168
NPM1 -6866
EML4 -6208
BCL11A -6104
BIRC6 -4462
PPM1B -3272
HIP1 -1416
FN1 1425


Formation of the ureteric bud
set Formation of the ureteric bud
setSize 5
pANOVA 0.045
s.dist -0.518
p.adjustANOVA 0.354


Top enriched genes
Top 20 genes
GeneID Gene Rank
WNT11 -8744
RET -7579
GREM1 -6755
ITGB1 -3865
FOXC1 -565

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WNT11 -8744
RET -7579
GREM1 -6755
ITGB1 -3865
FOXC1 -565


Gain-of-function MRAS complexes activate RAF signaling
set Gain-of-function MRAS complexes activate RAF signaling
setSize 8
pANOVA 0.0117
s.dist -0.515
p.adjustANOVA 0.161


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB -10145
SHOC2 -9676
BRAF -9432
PPP1CC -8350
YWHAB -7224
RAF1 -7158
MRAS -289
ARAF 8521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB -10145
SHOC2 -9676
BRAF -9432
PPP1CC -8350
YWHAB -7224
RAF1 -7158
MRAS -289
ARAF 8521


SHOC2 M1731 mutant abolishes MRAS complex function
set SHOC2 M1731 mutant abolishes MRAS complex function
setSize 8
pANOVA 0.0117
s.dist -0.515
p.adjustANOVA 0.161


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB -10145
SHOC2 -9676
BRAF -9432
PPP1CC -8350
YWHAB -7224
RAF1 -7158
MRAS -289
ARAF 8521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB -10145
SHOC2 -9676
BRAF -9432
PPP1CC -8350
YWHAB -7224
RAF1 -7158
MRAS -289
ARAF 8521


Signaling by MRAS-complex mutants
set Signaling by MRAS-complex mutants
setSize 8
pANOVA 0.0117
s.dist -0.515
p.adjustANOVA 0.161


Top enriched genes
Top 20 genes
GeneID Gene Rank
PPP1CB -10145
SHOC2 -9676
BRAF -9432
PPP1CC -8350
YWHAB -7224
RAF1 -7158
MRAS -289
ARAF 8521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP1CB -10145
SHOC2 -9676
BRAF -9432
PPP1CC -8350
YWHAB -7224
RAF1 -7158
MRAS -289
ARAF 8521


H139Hfs13* PPM1K causes a mild variant of MSUD
set H139Hfs13* PPM1K causes a mild variant of MSUD
setSize 5
pANOVA 0.0497
s.dist -0.507
p.adjustANOVA 0.37


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBT -9691
DLD -8714
PPM1K -8597
BCKDHB -4663
BCKDHA 4748

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBT -9691
DLD -8714
PPM1K -8597
BCKDHB -4663
BCKDHA 4748


Maple Syrup Urine Disease
set Maple Syrup Urine Disease
setSize 5
pANOVA 0.0497
s.dist -0.507
p.adjustANOVA 0.37


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBT -9691
DLD -8714
PPM1K -8597
BCKDHB -4663
BCKDHA 4748

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBT -9691
DLD -8714
PPM1K -8597
BCKDHB -4663
BCKDHA 4748


Synthesis of PI
set Synthesis of PI
setSize 5
pANOVA 0.0536
s.dist 0.498
p.adjustANOVA 0.374


Top enriched genes
Top 20 genes
GeneID Gene Rank
PITPNM1 8974
PITPNM2 8172
CDIPT 6633
PITPNM3 2548
CDS1 1705

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PITPNM1 8974
PITPNM2 8172
CDIPT 6633
PITPNM3 2548
CDS1 1705


Sulfide oxidation to sulfate
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0556
s.dist 0.494
p.adjustANOVA 0.375


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC25A10 9345
ETHE1 7861
TST 6509
TSTD1 6196
SUOX -2102

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A10 9345
ETHE1 7861
TST 6509
TSTD1 6196
SUOX -2102


Processing and activation of SUMO
set Processing and activation of SUMO
setSize 10
pANOVA 0.00738
s.dist -0.489
p.adjustANOVA 0.132


Top enriched genes
Top 20 genes
GeneID Gene Rank
SENP2 -10768
SUMO1 -10213
SENP1 -8965
SENP5 -8323
UBA2 -7566
SUMO2 -6318
RWDD3 -6026
SAE1 -2225
SUMO3 1265
UBE2I 7236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SENP2 -10768
SUMO1 -10213
SENP1 -8965
SENP5 -8323
UBA2 -7566
SUMO2 -6318
RWDD3 -6026
SAE1 -2225
SUMO3 1265
UBE2I 7236


Propionyl-CoA catabolism
set Propionyl-CoA catabolism
setSize 5
pANOVA 0.0602
s.dist -0.485
p.adjustANOVA 0.38


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCEE -8670
MMAA -8479
MMUT -4463
PCCA -3440
PCCB -685

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCEE -8670
MMAA -8479
MMUT -4463
PCCA -3440
PCCB -685


Wax and plasmalogen biosynthesis
set Wax and plasmalogen biosynthesis
setSize 5
pANOVA 0.0651
s.dist -0.476
p.adjustANOVA 0.392


Top enriched genes
Top 20 genes
GeneID Gene Rank
FAR1 -10212
GNPAT -9248
AGPS -8941
FAR2 -3250
DHRS7B 6400

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FAR1 -10212
GNPAT -9248
AGPS -8941
FAR2 -3250
DHRS7B 6400


SUMO is conjugated to E1 (UBA2:SAE1)
set SUMO is conjugated to E1 (UBA2:SAE1)
setSize 5
pANOVA 0.0671
s.dist -0.473
p.adjustANOVA 0.397


Top enriched genes
Top 20 genes
GeneID Gene Rank
SUMO1 -10213
UBA2 -7566
SUMO2 -6318
SAE1 -2225
SUMO3 1265

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUMO1 -10213
UBA2 -7566
SUMO2 -6318
SAE1 -2225
SUMO3 1265


SMAC (DIABLO) binds to IAPs
set SMAC (DIABLO) binds to IAPs
setSize 7
pANOVA 0.0337
s.dist -0.464
p.adjustANOVA 0.301


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348
DIABLO 2894

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348
DIABLO 2894


SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
set SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
setSize 7
pANOVA 0.0337
s.dist -0.464
p.adjustANOVA 0.301


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348
DIABLO 2894

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348
DIABLO 2894


SMAC, XIAP-regulated apoptotic response
set SMAC, XIAP-regulated apoptotic response
setSize 7
pANOVA 0.0337
s.dist -0.464
p.adjustANOVA 0.301


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348
DIABLO 2894

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -9729
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
CASP9 348
DIABLO 2894


Biosynthesis of Lipoxins (LX)
set Biosynthesis of Lipoxins (LX)
setSize 6
pANOVA 0.0494
s.dist 0.463
p.adjustANOVA 0.37


Top enriched genes
Top 20 genes
GeneID Gene Rank
LTC4S 10896
ALOX5 10584
ALOX5AP 5433
ALOX12 3715
PTGR1 521
HPGD 186

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All member genes
GeneID Gene Rank
LTC4S 10896
ALOX5 10584
ALOX5AP 5433
ALOX12 3715
PTGR1 521
HPGD 186


Signaling by cytosolic FGFR1 fusion mutants
set Signaling by cytosolic FGFR1 fusion mutants
setSize 18
pANOVA 0.000698
s.dist -0.462
p.adjustANOVA 0.0344


Top enriched genes
Top 20 genes
GeneID Gene Rank
ZMYM2 -10642
LRRFIP1 -10300
CEP43 -10242
PIK3CA -10063
TRIM24 -9457
FGFR1OP2 -7891
PIK3R1 -7814
CPSF6 -6272
GRB2 -4899
CNTRL -4318
STAT1 -4120
GAB2 -3835
CUX1 -329
STAT5B 165
STAT5A 256
BCR 328
MYO18A 416
STAT3 1086

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZMYM2 -10642
LRRFIP1 -10300
CEP43 -10242
PIK3CA -10063
TRIM24 -9457
FGFR1OP2 -7891
PIK3R1 -7814
CPSF6 -6272
GRB2 -4899
CNTRL -4318
STAT1 -4120
GAB2 -3835
CUX1 -329
STAT5B 165
STAT5A 256
BCR 328
MYO18A 416
STAT3 1086


Mitotic Telophase/Cytokinesis
set Mitotic Telophase/Cytokinesis
setSize 13
pANOVA 0.00451
s.dist -0.455
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
STAG1 -10448
STAG2 -9820
SMC3 -9444
NIPBL -9433
WAPL -8857
PDS5A -8674
PDS5B -8663
RAD21 -7420
SMC1A -4921
KIF20A -737
KIF23 3775
MAU2 5312
PLK1 6744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 -10448
STAG2 -9820
SMC3 -9444
NIPBL -9433
WAPL -8857
PDS5A -8674
PDS5B -8663
RAD21 -7420
SMC1A -4921
KIF20A -737
KIF23 3775
MAU2 5312
PLK1 6744


Cytochrome c-mediated apoptotic response
set Cytochrome c-mediated apoptotic response
setSize 13
pANOVA 0.00461
s.dist -0.454
p.adjustANOVA 0.103


Top enriched genes
Top 20 genes
GeneID Gene Rank
CASP3 -9729
APIP -9649
MAPK1 -9026
UACA -8028
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
AVEN -4881
CARD8 -4574
CASP9 348
DIABLO 2894
MAPK3 8108

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP3 -9729
APIP -9649
MAPK1 -9026
UACA -8028
CASP7 -7987
XIAP -7453
CYCS -6425
APAF1 -6022
AVEN -4881
CARD8 -4574
CASP9 348
DIABLO 2894
MAPK3 8108


Killing mechanisms
set Killing mechanisms
setSize 10
pANOVA 0.013
s.dist 0.454
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL1 10697
NOXA1 10436
DVL3 9465
CYBA 9237
NOXO1 8465
DVL2 7398
JUN 5404
RAC1 -227
FZD7 -886
MAPK8 -8832

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DVL1 10697
NOXA1 10436
DVL3 9465
CYBA 9237
NOXO1 8465
DVL2 7398
JUN 5404
RAC1 -227
FZD7 -886
MAPK8 -8832


WNT5:FZD7-mediated leishmania damping
set WNT5:FZD7-mediated leishmania damping
setSize 10
pANOVA 0.013
s.dist 0.454
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
DVL1 10697
NOXA1 10436
DVL3 9465
CYBA 9237
NOXO1 8465
DVL2 7398
JUN 5404
RAC1 -227
FZD7 -886
MAPK8 -8832

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DVL1 10697
NOXA1 10436
DVL3 9465
CYBA 9237
NOXO1 8465
DVL2 7398
JUN 5404
RAC1 -227
FZD7 -886
MAPK8 -8832


NOTCH4 Activation and Transmission of Signal to the Nucleus
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 10
pANOVA 0.0138
s.dist -0.45
p.adjustANOVA 0.173


Top enriched genes
Top 20 genes
GeneID Gene Rank
ADAM10 -10324
YWHAZ -9496
JAG1 -6092
APH1B -5321
PSEN1 -4897
PSENEN -4717
NOTCH4 -3208
NCSTN -2310
APH1A -1502
PSEN2 297

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADAM10 -10324
YWHAZ -9496
JAG1 -6092
APH1B -5321
PSEN1 -4897
PSENEN -4717
NOTCH4 -3208
NCSTN -2310
APH1A -1502
PSEN2 297


Lysosphingolipid and LPA receptors
set Lysosphingolipid and LPA receptors
setSize 11
pANOVA 0.0105
s.dist 0.446
p.adjustANOVA 0.156


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLPPR2 10365
LPAR2 10311
PLPPR3 10265
LPAR1 10179
S1PR4 7568
LPAR5 5573
S1PR3 5419
S1PR5 3826
S1PR1 -1577
LPAR3 -3172
S1PR2 -3462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLPPR2 10365
LPAR2 10311
PLPPR3 10265
LPAR1 10179
S1PR4 7568
LPAR5 5573
S1PR3 5419
S1PR5 3826
S1PR1 -1577
LPAR3 -3172
S1PR2 -3462


FGFR2b ligand binding and activation
set FGFR2b ligand binding and activation
setSize 6
pANOVA 0.0592
s.dist 0.445
p.adjustANOVA 0.38


Top enriched genes
Top 20 genes
GeneID Gene Rank
FGF22 10074
FGFBP2 9918
FGFR2 5697
FGF7 3982
FGFBP3 3896
FGF2 -3453

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF22 10074
FGFBP2 9918
FGFR2 5697
FGF7 3982
FGFBP3 3896
FGF2 -3453


Estrogen-stimulated signaling through PRKCZ
set Estrogen-stimulated signaling through PRKCZ
setSize 6
pANOVA 0.0615
s.dist -0.441
p.adjustANOVA 0.385


Top enriched genes
Top 20 genes
GeneID Gene Rank
NRAS -10628
MAPK1 -9026
KRAS -7826
PDPK1 -4298
PRKCZ -3758
HRAS 7571

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NRAS -10628
MAPK1 -9026
KRAS -7826
PDPK1 -4298
PRKCZ -3758
HRAS 7571


Fructose catabolism
set Fructose catabolism
setSize 5
pANOVA 0.0933
s.dist 0.433
p.adjustANOVA 0.454


Top enriched genes
Top 20 genes
GeneID Gene Rank
GLYCTK 10614
TKFC 8141
KHK 4791
ALDH1A1 4484
ALDOB -3556

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GLYCTK 10614
TKFC 8141
KHK 4791
ALDH1A1 4484
ALDOB -3556


Impaired BRCA2 binding to PALB2
set Impaired BRCA2 binding to PALB2
setSize 24
pANOVA 0.00026
s.dist -0.431
p.adjustANOVA 0.0295


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRE11 -10599
RAD51B -10402
BARD1 -9699
RBBP8 -9470
BRCA2 -8991
WRN -8576
BRIP1 -8306
BRCA1 -8190
DNA2 -7424
NBN -7418
PALB2 -7226
RMI1 -7187
RAD50 -5717
ATM -4333
TOP3A -3919
EXO1 -3422
BLM -2005
RAD51D -1823
RAD51AP1 -79
XRCC2 157

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRE11 -10599
RAD51B -10402
BARD1 -9699
RBBP8 -9470
BRCA2 -8991
WRN -8576
BRIP1 -8306
BRCA1 -8190
DNA2 -7424
NBN -7418
PALB2 -7226
RMI1 -7187
RAD50 -5717
ATM -4333
TOP3A -3919
EXO1 -3422
BLM -2005
RAD51D -1823
RAD51AP1 -79
XRCC2 157
KAT5 734
RAD51 3871
RAD51C 3873
RMI2 7050


Phenylalanine metabolism
set Phenylalanine metabolism
setSize 5
pANOVA 0.0976
s.dist 0.428
p.adjustANOVA 0.458


Top enriched genes
Top 20 genes
GeneID Gene Rank
PCBD1 9907
KYAT1 8498
ASRGL1 7043
IL4I1 4658
QDPR -5936

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCBD1 9907
KYAT1 8498
ASRGL1 7043
IL4I1 4658
QDPR -5936


Sensing of DNA Double Strand Breaks
set Sensing of DNA Double Strand Breaks
setSize 6
pANOVA 0.075
s.dist -0.42
p.adjustANOVA 0.409


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRE11 -10599
NBN -7418
RAD50 -5717
ATM -4333
KAT5 734
KPNA2 751

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRE11 -10599
NBN -7418
RAD50 -5717
ATM -4333
KAT5 734
KPNA2 751


Signaling by Hippo
set Signaling by Hippo
setSize 18
pANOVA 0.00206
s.dist -0.419
p.adjustANOVA 0.0674


Top enriched genes
Top 20 genes
GeneID Gene Rank
MOB1B -10486
MOB1A -10066
STK4 -9937
CASP3 -9729
SAV1 -8276
TJP2 -8001
LATS2 -7522
LATS1 -7388
YWHAB -7224
STK3 -6802
WWTR1 -5876
YWHAE -5830
AMOTL1 -3027
TJP1 -91
WWC1 1014
AMOT 1773
DVL2 7398
NPHP4 10425

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MOB1B -10486
MOB1A -10066
STK4 -9937
CASP3 -9729
SAV1 -8276
TJP2 -8001
LATS2 -7522
LATS1 -7388
YWHAB -7224
STK3 -6802
WWTR1 -5876
YWHAE -5830
AMOTL1 -3027
TJP1 -91
WWC1 1014
AMOT 1773
DVL2 7398
NPHP4 10425


Phenylalanine and tyrosine metabolism
set Phenylalanine and tyrosine metabolism
setSize 9
pANOVA 0.0313
s.dist 0.414
p.adjustANOVA 0.295


Top enriched genes
Top 20 genes
GeneID Gene Rank
PCBD1 9907
GSTZ1 9424
KYAT1 8498
ASRGL1 7043
HPD 6797
IL4I1 4658
HGD 1070
FAH 722
QDPR -5936

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCBD1 9907
GSTZ1 9424
KYAT1 8498
ASRGL1 7043
HPD 6797
IL4I1 4658
HGD 1070
FAH 722
QDPR -5936


ARMS-mediated activation
set ARMS-mediated activation
setSize 6
pANOVA 0.079
s.dist -0.414
p.adjustANOVA 0.414


Top enriched genes
Top 20 genes
GeneID Gene Rank
BRAF -9432
RAP1A -9260
YWHAB -7224
KIDINS220 -3981
CRK -3921
NTRK1 7600

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BRAF -9432
RAP1A -9260
YWHAB -7224
KIDINS220 -3981
CRK -3921
NTRK1 7600


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report