Mitch Report

date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	d1	d2	d3	d4	d5	d6
5_8S_rRNA	-0.6891322	-2.4785772	0.1666742	-1.6447949	-2.3372298	1.6789113
A1BG	0.2163555	-1.7542511	-1.0533748	0.7426509	0.1044466	-0.4773423
A1BG-AS1	-0.4425330	-1.0734377	-0.2260162	0.1261025	-0.3112331	0.3881952
A1CF	-0.5935004	0.5521424	1.1773907	-0.0456164	-0.9717789	-0.3059749
A2M	1.2986453	1.6603819	1.7931937	-1.6576434	-2.6139611	0.6340902
A2M-AS1	0.4479278	1.3818491	0.7455551	-2.2029246	-2.4240570	-1.0223656

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	21032
duplicated_genes_present	0
num_profile_genes_in_sets	8664
num_profile_genes_not_in_sets	12368

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1199
num_genesets_included	1526

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_t0_adj	s.crp_eos_adj	s.crp_pod1_adj	s.avb_t0_adj	s.avb_eos_adj	s.avb_pod1_adj	p.crp_t0_adj	p.crp_eos_adj	p.crp_pod1_adj	p.avb_t0_adj	p.avb_eos_adj	p.avb_pod1_adj
Regulation of NFE2L2 gene expression	8	5.25e-06	2.66e-05	1.37	5.89e-01	0.6430	0.5940	0.85300	0.162000	-0.0422	3.91e-03	1.64e-03	3.63e-03	2.95e-05	4.28e-01	8.36e-01
Protein repair	6	3.70e-03	9.59e-03	1.35	-5.13e-01	-0.4710	0.3860	-0.45400	-0.744000	0.6460	2.95e-02	4.56e-02	1.01e-01	5.40e-02	1.59e-03	6.11e-03
G2/M DNA replication checkpoint	5	3.62e-04	1.23e-03	1.34	-1.56e-01	-0.5450	0.6960	0.41600	-0.603000	0.6740	5.45e-01	3.47e-02	7.06e-03	1.07e-01	1.96e-02	9.03e-03
Interleukin-21 signaling	9	1.07e-05	5.11e-05	1.32	2.43e-01	0.6310	0.3240	0.70700	0.511000	0.6570	2.07e-01	1.05e-03	9.28e-02	2.37e-04	7.95e-03	6.47e-04
Response to metal ions	6	6.42e-04	2.02e-03	1.24	2.24e-01	-0.4390	0.7770	0.12700	-0.500000	0.6560	3.42e-01	6.25e-02	9.76e-04	5.91e-01	3.38e-02	5.37e-03
Formation of xylulose-5-phosphate	5	4.31e-03	1.10e-02	1.24	-5.65e-01	-0.5990	-0.7190	0.02570	0.551000	-0.2090	2.88e-02	2.03e-02	5.37e-03	9.21e-01	3.28e-02	4.18e-01
MECP2 regulates transcription of neuronal ligands	5	2.47e-02	4.82e-02	1.21	2.89e-01	0.4720	-0.1090	0.75500	0.726000	0.2340	2.63e-01	6.78e-02	6.72e-01	3.44e-03	4.90e-03	3.65e-01
CD163 mediating an anti-inflammatory response	8	2.08e-07	1.30e-06	1.19	-1.68e-01	0.0306	0.8750	-0.03820	-0.784000	-0.0578	4.12e-01	8.81e-01	1.80e-05	8.52e-01	1.22e-04	7.77e-01
Defective binding of VWF variant to GPIb:IX:V	5	7.13e-04	2.21e-03	1.18	4.13e-01	-0.7070	0.3280	-0.28200	-0.725000	0.1210	1.10e-01	6.16e-03	2.04e-01	2.75e-01	4.98e-03	6.39e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	5	7.13e-04	2.21e-03	1.18	4.13e-01	-0.7070	0.3280	-0.28200	-0.725000	0.1210	1.10e-01	6.16e-03	2.04e-01	2.75e-01	4.98e-03	6.39e-01
SUMO is conjugated to E1 (UBA2:SAE1)	5	1.67e-02	3.46e-02	1.16	-6.69e-01	-0.7380	-0.2370	-0.00341	-0.366000	0.4090	9.56e-03	4.25e-03	3.59e-01	9.89e-01	1.57e-01	1.13e-01
Formation of a pool of free 40S subunits	99	7.50e-58	7.58e-56	1.16	-2.57e-01	-0.8480	-0.6830	-0.11300	-0.032600	-0.2670	1.02e-05	2.07e-48	5.66e-32	5.16e-02	5.75e-01	4.42e-06
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	5	4.06e-02	7.37e-02	1.16	4.96e-01	0.5310	0.4840	0.35500	0.097600	0.6600	5.48e-02	3.96e-02	6.07e-02	1.69e-01	7.05e-01	1.06e-02
Peptide chain elongation	87	1.23e-51	1.02e-49	1.15	-2.30e-01	-0.8500	-0.6810	-0.11000	-0.003250	-0.2730	2.08e-04	6.93e-43	4.40e-28	7.65e-02	9.58e-01	1.06e-05
Eukaryotic Translation Elongation	92	1.27e-53	1.22e-51	1.13	-2.15e-01	-0.8410	-0.6690	-0.10300	0.000647	-0.2640	3.64e-04	2.38e-44	1.27e-28	8.73e-02	9.91e-01	1.22e-05
Tandem pore domain potassium channels	5	3.28e-03	8.65e-03	1.12	-2.74e-01	0.4670	0.3650	0.42400	0.684000	0.4320	2.88e-01	7.06e-02	1.58e-01	1.00e-01	8.09e-03	9.41e-02
Viral mRNA Translation	87	4.37e-49	3.00e-47	1.12	-2.36e-01	-0.8380	-0.6550	-0.11300	-0.017800	-0.2420	1.44e-04	9.14e-42	4.10e-26	6.76e-02	7.75e-01	9.39e-05
L13a-mediated translational silencing of Ceruloplasmin expression	109	1.40e-58	1.58e-56	1.12	-2.89e-01	-0.8310	-0.6400	-0.13200	-0.070300	-0.2270	1.77e-07	4.72e-51	7.21e-31	1.75e-02	2.05e-01	4.20e-05
MET activates PI3K/AKT signaling	5	2.38e-03	6.47e-03	1.12	-4.46e-01	0.5910	0.4900	-0.23700	-0.436000	0.4580	8.41e-02	2.21e-02	5.78e-02	3.58e-01	9.12e-02	7.62e-02
Type I hemidesmosome assembly	8	2.40e-03	6.52e-03	1.11	1.84e-01	0.3570	0.5690	0.59400	0.275000	0.5740	3.68e-01	8.05e-02	5.35e-03	3.59e-03	1.78e-01	4.93e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	110	4.14e-58	4.41e-56	1.11	-2.88e-01	-0.8270	-0.6270	-0.13700	-0.069500	-0.2220	1.77e-07	5.92e-51	5.23e-30	1.32e-02	2.08e-01	5.62e-05
Modulation by Mtb of host immune system	7	1.11e-02	2.45e-02	1.11	-4.33e-01	-0.8230	-0.3280	-0.14300	-0.486000	0.0329	4.73e-02	1.64e-04	1.33e-01	5.12e-01	2.61e-02	8.80e-01
Selenocysteine synthesis	91	2.18e-49	1.67e-47	1.11	-2.29e-01	-0.8110	-0.6630	-0.08950	0.003510	-0.2580	1.64e-04	6.76e-41	6.47e-28	1.40e-01	9.54e-01	2.17e-05
SARS-CoV-1 modulates host translation machinery	36	8.89e-19	1.54e-17	1.10	-1.98e-01	-0.8160	-0.6550	-0.12200	-0.017500	-0.2660	4.00e-02	2.26e-17	1.04e-11	2.04e-01	8.56e-01	5.75e-03
Formation of the ternary complex, and subsequently, the 43S complex	51	2.16e-25	4.45e-24	1.10	-2.81e-01	-0.8090	-0.6420	-0.14200	-0.084400	-0.2150	5.28e-04	1.40e-23	2.13e-15	8.04e-02	2.97e-01	7.91e-03
Cap-dependent Translation Initiation	117	3.54e-61	4.25e-59	1.10	-2.79e-01	-0.8210	-0.6230	-0.13000	-0.061200	-0.2300	1.82e-07	2.52e-53	1.96e-31	1.53e-02	2.53e-01	1.73e-05
Eukaryotic Translation Initiation	117	3.54e-61	4.25e-59	1.10	-2.79e-01	-0.8210	-0.6230	-0.13000	-0.061200	-0.2300	1.82e-07	2.52e-53	1.96e-31	1.53e-02	2.53e-01	1.73e-05
Phosphate bond hydrolysis by NUDT proteins	7	2.00e-02	4.01e-02	1.10	-5.90e-01	-0.7450	-0.4330	-0.25700	-0.231000	-0.0153	6.88e-03	6.38e-04	4.73e-02	2.39e-01	2.91e-01	9.44e-01
Eukaryotic Translation Termination	91	2.42e-49	1.72e-47	1.10	-2.20e-01	-0.8160	-0.6520	-0.08550	-0.002980	-0.2420	2.84e-04	2.01e-41	5.47e-27	1.59e-01	9.61e-01	6.79e-05
POLB-Dependent Long Patch Base Excision Repair	8	1.94e-03	5.42e-03	1.09	1.60e-01	-0.2590	-0.5700	0.65900	0.552000	-0.1610	4.33e-01	2.04e-01	5.20e-03	1.25e-03	6.82e-03	4.31e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	6.12e-48	3.79e-46	1.08	-2.29e-01	-0.8080	-0.6340	-0.08590	-0.037000	-0.2440	1.37e-04	1.72e-41	3.72e-26	1.52e-01	5.37e-01	4.64e-05
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	6.42e-27	1.45e-25	1.08	-3.25e-01	-0.7930	-0.5960	-0.15500	-0.134000	-0.2060	1.53e-05	5.37e-26	2.33e-15	3.91e-02	7.60e-02	6.10e-03
Translation initiation complex formation	58	4.05e-26	8.93e-25	1.07	-3.19e-01	-0.7900	-0.5900	-0.14700	-0.133000	-0.1940	2.59e-05	2.16e-25	7.05e-15	5.27e-02	8.07e-02	1.07e-02
Ribosomal scanning and start codon recognition	58	1.15e-25	2.42e-24	1.07	-3.20e-01	-0.7880	-0.5770	-0.15400	-0.134000	-0.2000	2.54e-05	2.74e-25	2.91e-14	4.27e-02	7.79e-02	8.44e-03
Fructose metabolism	7	7.23e-03	1.71e-02	1.06	-2.75e-01	-0.2260	-0.5790	-0.14000	0.388000	-0.7030	2.08e-01	3.01e-01	7.96e-03	5.21e-01	7.55e-02	1.28e-03
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.86e-02	5.47e-02	1.05	6.62e-02	0.2210	0.8170	0.12700	-0.016700	0.6100	7.79e-01	3.49e-01	5.29e-04	5.89e-01	9.44e-01	9.64e-03
SRP-dependent cotranslational protein targeting to membrane	110	6.87e-53	6.27e-51	1.05	-3.14e-01	-0.8100	-0.5610	-0.09840	-0.104000	-0.0969	1.30e-08	5.61e-49	2.56e-24	7.45e-02	5.87e-02	7.90e-02
Acetylcholine binding and downstream events	5	5.08e-02	8.77e-02	1.04	2.68e-01	0.2850	0.6440	0.59100	-0.078200	0.4080	2.99e-01	2.70e-01	1.27e-02	2.20e-02	7.62e-01	1.14e-01
Postsynaptic nicotinic acetylcholine receptors	5	5.08e-02	8.77e-02	1.04	2.68e-01	0.2850	0.6440	0.59100	-0.078200	0.4080	2.99e-01	2.70e-01	1.27e-02	2.20e-02	7.62e-01	1.14e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	8.88e-03	2.02e-02	1.04	7.93e-05	0.3430	0.5940	-0.15000	-0.690000	0.3420	1.00e+00	1.46e-01	1.18e-02	5.26e-01	3.42e-03	1.47e-01
Replacement of protamines by nucleosomes in the male pronucleus	12	3.11e-04	1.07e-03	1.04	-2.82e-01	-0.6130	0.2510	-0.28600	-0.629000	0.3000	9.13e-02	2.37e-04	1.33e-01	8.66e-02	1.63e-04	7.15e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	6.63e-02	1.09e-01	1.04	-4.12e-01	-0.6780	-0.5750	0.23300	0.037800	-0.2560	1.11e-01	8.61e-03	2.60e-02	3.67e-01	8.84e-01	3.22e-01
Activation of caspases through apoptosome-mediated cleavage	6	6.57e-03	1.57e-02	1.04	-5.97e-01	-0.2860	0.1480	-0.09980	0.027400	0.7810	1.13e-02	2.25e-01	5.30e-01	6.72e-01	9.08e-01	9.27e-04
Phosphorylation of Emi1	6	4.76e-03	1.19e-02	1.03	2.32e-01	-0.2470	0.4390	0.73400	-0.098600	0.4530	3.26e-01	2.94e-01	6.28e-02	1.85e-03	6.76e-01	5.46e-02
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	2.11e-08	1.57e-07	1.02	-9.45e-02	-0.7230	-0.0367	-0.14000	-0.691000	-0.1460	4.76e-01	4.93e-08	7.82e-01	2.91e-01	1.84e-07	2.70e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	3.51e-46	1.98e-44	1.02	-2.31e-01	-0.7690	-0.5830	-0.13700	-0.033000	-0.2130	7.38e-05	4.63e-40	1.04e-23	1.83e-02	5.71e-01	2.42e-04
Post-transcriptional silencing by small RNAs	7	1.57e-03	4.48e-03	1.02	-2.11e-01	0.7140	0.3230	0.24500	0.377000	0.4190	3.33e-01	1.06e-03	1.39e-01	2.61e-01	8.43e-02	5.46e-02
CD22 mediated BCR regulation	57	1.32e-36	4.97e-35	1.01	1.55e-01	-0.5510	0.2320	0.41000	-0.520000	0.4500	4.31e-02	5.94e-13	2.44e-03	8.39e-08	1.06e-11	4.24e-09
G2 Phase	5	4.84e-02	8.42e-02	1.01	-6.50e-02	-0.5030	0.4510	0.11300	-0.615000	0.4030	8.01e-01	5.14e-02	8.10e-02	6.60e-01	1.72e-02	1.19e-01
Mitochondrial translation initiation	90	2.27e-46	1.36e-44	1.00	-1.12e-01	-0.8030	-0.5660	0.09000	-0.101000	-0.0876	6.58e-02	9.09e-40	1.53e-20	1.40e-01	9.64e-02	1.51e-01

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Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_t0_adj	s.crp_eos_adj	s.crp_pod1_adj	s.avb_t0_adj	s.avb_eos_adj	s.avb_pod1_adj	p.crp_t0_adj	p.crp_eos_adj	p.crp_pod1_adj	p.avb_t0_adj	p.avb_eos_adj	p.avb_pod1_adj
Regulation of NFE2L2 gene expression	8	5.25e-06	2.66e-05	1.370	5.89e-01	6.43e-01	5.94e-01	8.53e-01	1.62e-01	-0.042200	3.91e-03	1.64e-03	3.63e-03	2.95e-05	4.28e-01	8.36e-01
Protein repair	6	3.70e-03	9.59e-03	1.350	-5.13e-01	-4.71e-01	3.86e-01	-4.54e-01	-7.44e-01	0.646000	2.95e-02	4.56e-02	1.01e-01	5.40e-02	1.59e-03	6.11e-03
G2/M DNA replication checkpoint	5	3.62e-04	1.23e-03	1.340	-1.56e-01	-5.45e-01	6.96e-01	4.16e-01	-6.03e-01	0.674000	5.45e-01	3.47e-02	7.06e-03	1.07e-01	1.96e-02	9.03e-03
Interleukin-21 signaling	9	1.07e-05	5.11e-05	1.320	2.43e-01	6.31e-01	3.24e-01	7.07e-01	5.11e-01	0.657000	2.07e-01	1.05e-03	9.28e-02	2.37e-04	7.95e-03	6.47e-04
Response to metal ions	6	6.42e-04	2.02e-03	1.240	2.24e-01	-4.39e-01	7.77e-01	1.27e-01	-5.00e-01	0.656000	3.42e-01	6.25e-02	9.76e-04	5.91e-01	3.38e-02	5.37e-03
Formation of xylulose-5-phosphate	5	4.31e-03	1.10e-02	1.240	-5.65e-01	-5.99e-01	-7.19e-01	2.57e-02	5.51e-01	-0.209000	2.88e-02	2.03e-02	5.37e-03	9.21e-01	3.28e-02	4.18e-01
MECP2 regulates transcription of neuronal ligands	5	2.47e-02	4.82e-02	1.210	2.89e-01	4.72e-01	-1.09e-01	7.55e-01	7.26e-01	0.234000	2.63e-01	6.78e-02	6.72e-01	3.44e-03	4.90e-03	3.65e-01
CD163 mediating an anti-inflammatory response	8	2.08e-07	1.30e-06	1.190	-1.68e-01	3.06e-02	8.75e-01	-3.82e-02	-7.84e-01	-0.057800	4.12e-01	8.81e-01	1.80e-05	8.52e-01	1.22e-04	7.77e-01
Defective binding of VWF variant to GPIb:IX:V	5	7.13e-04	2.21e-03	1.180	4.13e-01	-7.07e-01	3.28e-01	-2.82e-01	-7.25e-01	0.121000	1.10e-01	6.16e-03	2.04e-01	2.75e-01	4.98e-03	6.39e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	5	7.13e-04	2.21e-03	1.180	4.13e-01	-7.07e-01	3.28e-01	-2.82e-01	-7.25e-01	0.121000	1.10e-01	6.16e-03	2.04e-01	2.75e-01	4.98e-03	6.39e-01
SUMO is conjugated to E1 (UBA2:SAE1)	5	1.67e-02	3.46e-02	1.160	-6.69e-01	-7.38e-01	-2.37e-01	-3.41e-03	-3.66e-01	0.409000	9.56e-03	4.25e-03	3.59e-01	9.89e-01	1.57e-01	1.13e-01
Formation of a pool of free 40S subunits	99	7.50e-58	7.58e-56	1.160	-2.57e-01	-8.48e-01	-6.83e-01	-1.13e-01	-3.26e-02	-0.267000	1.02e-05	2.07e-48	5.66e-32	5.16e-02	5.75e-01	4.42e-06
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	5	4.06e-02	7.37e-02	1.160	4.96e-01	5.31e-01	4.84e-01	3.55e-01	9.76e-02	0.660000	5.48e-02	3.96e-02	6.07e-02	1.69e-01	7.05e-01	1.06e-02
Peptide chain elongation	87	1.23e-51	1.02e-49	1.150	-2.30e-01	-8.50e-01	-6.81e-01	-1.10e-01	-3.25e-03	-0.273000	2.08e-04	6.93e-43	4.40e-28	7.65e-02	9.58e-01	1.06e-05
Eukaryotic Translation Elongation	92	1.27e-53	1.22e-51	1.130	-2.15e-01	-8.41e-01	-6.69e-01	-1.03e-01	6.47e-04	-0.264000	3.64e-04	2.38e-44	1.27e-28	8.73e-02	9.91e-01	1.22e-05
Tandem pore domain potassium channels	5	3.28e-03	8.65e-03	1.120	-2.74e-01	4.67e-01	3.65e-01	4.24e-01	6.84e-01	0.432000	2.88e-01	7.06e-02	1.58e-01	1.00e-01	8.09e-03	9.41e-02
Viral mRNA Translation	87	4.37e-49	3.00e-47	1.120	-2.36e-01	-8.38e-01	-6.55e-01	-1.13e-01	-1.78e-02	-0.242000	1.44e-04	9.14e-42	4.10e-26	6.76e-02	7.75e-01	9.39e-05
L13a-mediated translational silencing of Ceruloplasmin expression	109	1.40e-58	1.58e-56	1.120	-2.89e-01	-8.31e-01	-6.40e-01	-1.32e-01	-7.03e-02	-0.227000	1.77e-07	4.72e-51	7.21e-31	1.75e-02	2.05e-01	4.20e-05
MET activates PI3K/AKT signaling	5	2.38e-03	6.47e-03	1.120	-4.46e-01	5.91e-01	4.90e-01	-2.37e-01	-4.36e-01	0.458000	8.41e-02	2.21e-02	5.78e-02	3.58e-01	9.12e-02	7.62e-02
Type I hemidesmosome assembly	8	2.40e-03	6.52e-03	1.110	1.84e-01	3.57e-01	5.69e-01	5.94e-01	2.75e-01	0.574000	3.68e-01	8.05e-02	5.35e-03	3.59e-03	1.78e-01	4.93e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	110	4.14e-58	4.41e-56	1.110	-2.88e-01	-8.27e-01	-6.27e-01	-1.37e-01	-6.95e-02	-0.222000	1.77e-07	5.92e-51	5.23e-30	1.32e-02	2.08e-01	5.62e-05
Modulation by Mtb of host immune system	7	1.11e-02	2.45e-02	1.110	-4.33e-01	-8.23e-01	-3.28e-01	-1.43e-01	-4.86e-01	0.032900	4.73e-02	1.64e-04	1.33e-01	5.12e-01	2.61e-02	8.80e-01
Selenocysteine synthesis	91	2.18e-49	1.67e-47	1.110	-2.29e-01	-8.11e-01	-6.63e-01	-8.95e-02	3.51e-03	-0.258000	1.64e-04	6.76e-41	6.47e-28	1.40e-01	9.54e-01	2.17e-05
SARS-CoV-1 modulates host translation machinery	36	8.89e-19	1.54e-17	1.100	-1.98e-01	-8.16e-01	-6.55e-01	-1.22e-01	-1.75e-02	-0.266000	4.00e-02	2.26e-17	1.04e-11	2.04e-01	8.56e-01	5.75e-03
Formation of the ternary complex, and subsequently, the 43S complex	51	2.16e-25	4.45e-24	1.100	-2.81e-01	-8.09e-01	-6.42e-01	-1.42e-01	-8.44e-02	-0.215000	5.28e-04	1.40e-23	2.13e-15	8.04e-02	2.97e-01	7.91e-03
Cap-dependent Translation Initiation	117	3.54e-61	4.25e-59	1.100	-2.79e-01	-8.21e-01	-6.23e-01	-1.30e-01	-6.12e-02	-0.230000	1.82e-07	2.52e-53	1.96e-31	1.53e-02	2.53e-01	1.73e-05
Eukaryotic Translation Initiation	117	3.54e-61	4.25e-59	1.100	-2.79e-01	-8.21e-01	-6.23e-01	-1.30e-01	-6.12e-02	-0.230000	1.82e-07	2.52e-53	1.96e-31	1.53e-02	2.53e-01	1.73e-05
Phosphate bond hydrolysis by NUDT proteins	7	2.00e-02	4.01e-02	1.100	-5.90e-01	-7.45e-01	-4.33e-01	-2.57e-01	-2.31e-01	-0.015300	6.88e-03	6.38e-04	4.73e-02	2.39e-01	2.91e-01	9.44e-01
Eukaryotic Translation Termination	91	2.42e-49	1.72e-47	1.100	-2.20e-01	-8.16e-01	-6.52e-01	-8.55e-02	-2.98e-03	-0.242000	2.84e-04	2.01e-41	5.47e-27	1.59e-01	9.61e-01	6.79e-05
POLB-Dependent Long Patch Base Excision Repair	8	1.94e-03	5.42e-03	1.090	1.60e-01	-2.59e-01	-5.70e-01	6.59e-01	5.52e-01	-0.161000	4.33e-01	2.04e-01	5.20e-03	1.25e-03	6.82e-03	4.31e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	6.12e-48	3.79e-46	1.080	-2.29e-01	-8.08e-01	-6.34e-01	-8.59e-02	-3.70e-02	-0.244000	1.37e-04	1.72e-41	3.72e-26	1.52e-01	5.37e-01	4.64e-05
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	6.42e-27	1.45e-25	1.080	-3.25e-01	-7.93e-01	-5.96e-01	-1.55e-01	-1.34e-01	-0.206000	1.53e-05	5.37e-26	2.33e-15	3.91e-02	7.60e-02	6.10e-03
Translation initiation complex formation	58	4.05e-26	8.93e-25	1.070	-3.19e-01	-7.90e-01	-5.90e-01	-1.47e-01	-1.33e-01	-0.194000	2.59e-05	2.16e-25	7.05e-15	5.27e-02	8.07e-02	1.07e-02
Ribosomal scanning and start codon recognition	58	1.15e-25	2.42e-24	1.070	-3.20e-01	-7.88e-01	-5.77e-01	-1.54e-01	-1.34e-01	-0.200000	2.54e-05	2.74e-25	2.91e-14	4.27e-02	7.79e-02	8.44e-03
Fructose metabolism	7	7.23e-03	1.71e-02	1.060	-2.75e-01	-2.26e-01	-5.79e-01	-1.40e-01	3.88e-01	-0.703000	2.08e-01	3.01e-01	7.96e-03	5.21e-01	7.55e-02	1.28e-03
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.86e-02	5.47e-02	1.050	6.62e-02	2.21e-01	8.17e-01	1.27e-01	-1.67e-02	0.610000	7.79e-01	3.49e-01	5.29e-04	5.89e-01	9.44e-01	9.64e-03
SRP-dependent cotranslational protein targeting to membrane	110	6.87e-53	6.27e-51	1.050	-3.14e-01	-8.10e-01	-5.61e-01	-9.84e-02	-1.04e-01	-0.096900	1.30e-08	5.61e-49	2.56e-24	7.45e-02	5.87e-02	7.90e-02
Acetylcholine binding and downstream events	5	5.08e-02	8.77e-02	1.040	2.68e-01	2.85e-01	6.44e-01	5.91e-01	-7.82e-02	0.408000	2.99e-01	2.70e-01	1.27e-02	2.20e-02	7.62e-01	1.14e-01
Postsynaptic nicotinic acetylcholine receptors	5	5.08e-02	8.77e-02	1.040	2.68e-01	2.85e-01	6.44e-01	5.91e-01	-7.82e-02	0.408000	2.99e-01	2.70e-01	1.27e-02	2.20e-02	7.62e-01	1.14e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	8.88e-03	2.02e-02	1.040	7.93e-05	3.43e-01	5.94e-01	-1.50e-01	-6.90e-01	0.342000	1.00e+00	1.46e-01	1.18e-02	5.26e-01	3.42e-03	1.47e-01
Replacement of protamines by nucleosomes in the male pronucleus	12	3.11e-04	1.07e-03	1.040	-2.82e-01	-6.13e-01	2.51e-01	-2.86e-01	-6.29e-01	0.300000	9.13e-02	2.37e-04	1.33e-01	8.66e-02	1.63e-04	7.15e-02
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	6.63e-02	1.09e-01	1.040	-4.12e-01	-6.78e-01	-5.75e-01	2.33e-01	3.78e-02	-0.256000	1.11e-01	8.61e-03	2.60e-02	3.67e-01	8.84e-01	3.22e-01
Activation of caspases through apoptosome-mediated cleavage	6	6.57e-03	1.57e-02	1.040	-5.97e-01	-2.86e-01	1.48e-01	-9.98e-02	2.74e-02	0.781000	1.13e-02	2.25e-01	5.30e-01	6.72e-01	9.08e-01	9.27e-04
Phosphorylation of Emi1	6	4.76e-03	1.19e-02	1.030	2.32e-01	-2.47e-01	4.39e-01	7.34e-01	-9.86e-02	0.453000	3.26e-01	2.94e-01	6.28e-02	1.85e-03	6.76e-01	5.46e-02
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	2.11e-08	1.57e-07	1.020	-9.45e-02	-7.23e-01	-3.67e-02	-1.40e-01	-6.91e-01	-0.146000	4.76e-01	4.93e-08	7.82e-01	2.91e-01	1.84e-07	2.70e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	3.51e-46	1.98e-44	1.020	-2.31e-01	-7.69e-01	-5.83e-01	-1.37e-01	-3.30e-02	-0.213000	7.38e-05	4.63e-40	1.04e-23	1.83e-02	5.71e-01	2.42e-04
Post-transcriptional silencing by small RNAs	7	1.57e-03	4.48e-03	1.020	-2.11e-01	7.14e-01	3.23e-01	2.45e-01	3.77e-01	0.419000	3.33e-01	1.06e-03	1.39e-01	2.61e-01	8.43e-02	5.46e-02
CD22 mediated BCR regulation	57	1.32e-36	4.97e-35	1.010	1.55e-01	-5.51e-01	2.32e-01	4.10e-01	-5.20e-01	0.450000	4.31e-02	5.94e-13	2.44e-03	8.39e-08	1.06e-11	4.24e-09
G2 Phase	5	4.84e-02	8.42e-02	1.010	-6.50e-02	-5.03e-01	4.51e-01	1.13e-01	-6.15e-01	0.403000	8.01e-01	5.14e-02	8.10e-02	6.60e-01	1.72e-02	1.19e-01
Mitochondrial translation initiation	90	2.27e-46	1.36e-44	1.000	-1.12e-01	-8.03e-01	-5.66e-01	9.00e-02	-1.01e-01	-0.087600	6.58e-02	9.09e-40	1.53e-20	1.40e-01	9.64e-02	1.51e-01
Regulation of NPAS4 gene expression	11	4.20e-05	1.80e-04	0.999	-1.50e-01	6.11e-01	2.83e-01	3.27e-01	4.09e-01	0.497000	3.90e-01	4.46e-04	1.04e-01	6.04e-02	1.88e-02	4.34e-03
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	8.76e-03	1.99e-02	0.999	-4.93e-01	-6.90e-01	-3.92e-01	7.17e-02	-2.20e-01	0.266000	2.38e-02	1.57e-03	7.28e-02	7.43e-01	3.14e-01	2.22e-01
Formation of ATP by chemiosmotic coupling	20	3.91e-08	2.73e-07	0.998	-3.10e-01	-8.50e-01	-2.99e-01	2.91e-02	-2.92e-01	0.035100	1.63e-02	4.58e-11	2.08e-02	8.22e-01	2.37e-02	7.86e-01
Wax and plasmalogen biosynthesis	5	5.28e-02	9.08e-02	0.992	-6.33e-01	-3.52e-01	6.92e-02	-2.84e-01	-3.39e-02	0.611000	1.43e-02	1.72e-01	7.89e-01	2.72e-01	8.96e-01	1.80e-02
ARMS-mediated activation	6	4.24e-02	7.57e-02	0.991	-4.50e-01	5.99e-02	3.56e-01	-3.25e-01	-2.98e-01	0.675000	5.63e-02	8.00e-01	1.31e-01	1.68e-01	2.06e-01	4.17e-03
Mitochondrial translation elongation	90	1.42e-44	7.00e-43	0.988	-1.01e-01	-7.90e-01	-5.57e-01	9.70e-02	-1.00e-01	-0.111000	9.76e-02	1.62e-38	5.97e-20	1.12e-01	9.99e-02	6.94e-02
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	9.18e-03	2.07e-02	0.983	2.11e-02	-3.72e-02	4.60e-01	4.83e-01	-1.37e-01	0.708000	9.23e-01	8.65e-01	3.49e-02	2.70e-02	5.29e-01	1.17e-03
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	7.57e-03	1.77e-02	0.980	-4.19e-02	1.36e-01	-8.41e-02	6.94e-01	4.58e-01	-0.491000	8.71e-01	5.99e-01	7.45e-01	7.18e-03	7.60e-02	5.70e-02
PDH complex synthesizes acetyl-CoA from PYR	5	1.27e-01	1.85e-01	0.974	-5.71e-01	-6.20e-01	-1.64e-01	-2.44e-01	-1.95e-01	0.338000	2.70e-02	1.64e-02	5.26e-01	3.45e-01	4.50e-01	1.91e-01
Mitochondrial translation termination	90	3.40e-43	1.63e-41	0.973	-1.05e-01	-7.80e-01	-5.48e-01	8.07e-02	-1.00e-01	-0.100000	8.47e-02	1.48e-37	2.30e-19	1.86e-01	9.95e-02	1.01e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	4.08e-02	7.38e-02	0.968	1.02e-01	-1.38e-01	-5.02e-01	5.22e-01	5.51e-01	-0.281000	6.41e-01	5.27e-01	2.15e-02	1.67e-02	1.16e-02	1.98e-01
Mitochondrial translation	96	8.37e-45	4.34e-43	0.968	-1.26e-01	-7.73e-01	-5.48e-01	6.52e-02	-9.44e-02	-0.101000	3.31e-02	3.05e-39	1.60e-20	2.70e-01	1.10e-01	8.65e-02
Erythrocytes take up oxygen and release carbon dioxide	7	4.38e-02	7.76e-02	0.967	5.22e-01	3.97e-01	6.17e-01	2.32e-01	-1.81e-01	0.193000	1.68e-02	6.91e-02	4.67e-03	2.88e-01	4.08e-01	3.76e-01
Selenoamino acid metabolism	114	2.62e-45	1.40e-43	0.967	-2.45e-01	-7.16e-01	-5.52e-01	-8.07e-02	-1.76e-02	-0.224000	6.07e-06	5.87e-40	2.07e-24	1.36e-01	7.46e-01	3.62e-05
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	5.39e-02	9.26e-02	0.965	-4.72e-01	-6.33e-01	-5.26e-01	9.41e-02	1.30e-01	-0.073900	4.54e-02	7.23e-03	2.57e-02	6.90e-01	5.80e-01	7.54e-01
Complex III assembly	23	2.11e-08	1.57e-07	0.964	-2.20e-01	-7.58e-01	-4.75e-01	5.34e-02	-7.26e-02	-0.271000	6.78e-02	3.11e-10	7.95e-05	6.58e-01	5.47e-01	2.46e-02
Cohesin Loading onto Chromatin	10	6.56e-06	3.25e-05	0.964	-4.44e-01	4.62e-01	3.94e-01	2.76e-01	6.09e-02	0.532000	1.49e-02	1.14e-02	3.08e-02	1.31e-01	7.39e-01	3.60e-03
RNA Polymerase I Promoter Opening	17	3.09e-06	1.63e-05	0.963	-1.88e-01	-6.73e-01	2.13e-01	-1.93e-01	-5.10e-01	0.312000	1.79e-01	1.57e-06	1.29e-01	1.68e-01	2.69e-04	2.61e-02
Abacavir ADME	5	1.11e-01	1.65e-01	0.962	5.66e-01	5.56e-01	3.16e-01	3.68e-01	-3.05e-02	0.246000	2.85e-02	3.14e-02	2.21e-01	1.54e-01	9.06e-01	3.40e-01
Fructose catabolism	5	7.93e-02	1.27e-01	0.961	-1.25e-01	-2.53e-01	-4.84e-01	-3.02e-01	2.66e-01	-0.668000	6.28e-01	3.27e-01	6.08e-02	2.42e-01	3.03e-01	9.66e-03
Regulation of CDH11 mRNA translation by microRNAs	8	2.66e-03	7.12e-03	0.961	-1.16e-01	6.33e-01	2.04e-01	3.22e-01	4.50e-01	0.401000	5.70e-01	1.93e-03	3.17e-01	1.15e-01	2.75e-02	4.97e-02
Regulation of NPAS4 mRNA translation	8	2.66e-03	7.12e-03	0.961	-1.16e-01	6.33e-01	2.04e-01	3.22e-01	4.50e-01	0.401000	5.70e-01	1.93e-03	3.17e-01	1.15e-01	2.75e-02	4.97e-02
Propionyl-CoA catabolism	5	5.82e-02	9.89e-02	0.960	-3.55e-01	-3.08e-01	-5.13e-01	2.50e-01	6.01e-01	-0.124000	1.69e-01	2.33e-01	4.72e-02	3.33e-01	2.00e-02	6.31e-01
Interleukin-9 signaling	8	1.71e-02	3.51e-02	0.951	2.11e-01	4.32e-01	2.48e-01	5.57e-01	2.84e-01	0.469000	3.01e-01	3.42e-02	2.25e-01	6.35e-03	1.65e-01	2.17e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.76e-04	6.44e-04	0.946	-3.31e-01	-4.99e-01	3.34e-01	1.56e-02	-4.72e-01	0.449000	3.89e-02	1.83e-03	3.68e-02	9.22e-01	3.24e-03	5.03e-03
Cation-coupled Chloride cotransporters	6	1.41e-01	2.01e-01	0.943	4.43e-01	6.01e-01	3.67e-01	2.95e-01	3.27e-01	-0.047100	6.01e-02	1.08e-02	1.19e-01	2.11e-01	1.65e-01	8.42e-01
Mitochondrial RNA degradation	25	7.35e-09	5.71e-08	0.941	-1.19e-01	-6.79e-01	-9.76e-02	-1.55e-01	-6.06e-01	-0.094700	3.01e-01	4.05e-09	3.98e-01	1.79e-01	1.54e-07	4.13e-01
Regulation of IFNA/IFNB signaling	12	7.92e-04	2.43e-03	0.941	2.84e-03	3.15e-01	4.43e-01	2.96e-01	2.03e-01	0.679000	9.86e-01	5.86e-02	7.82e-03	7.56e-02	2.24e-01	4.65e-05
Formyl peptide receptors bind formyl peptides and many other ligands	7	6.06e-02	1.02e-01	0.941	-4.90e-01	-4.39e-01	8.65e-02	-2.98e-01	-3.53e-01	0.481000	2.46e-02	4.45e-02	6.92e-01	1.72e-01	1.06e-01	2.77e-02
SARS-CoV-2 modulates host translation machinery	49	5.70e-21	1.07e-19	0.939	-6.89e-02	-7.26e-01	-5.49e-01	-3.80e-02	1.23e-02	-0.213000	4.04e-01	1.34e-18	2.79e-11	6.45e-01	8.81e-01	9.97e-03
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	2.10e-04	7.55e-04	0.936	-4.74e-02	2.57e-01	2.84e-01	7.55e-01	3.71e-01	-0.139000	8.28e-01	2.39e-01	1.93e-01	5.43e-04	8.88e-02	5.23e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	4.61e-02	8.07e-02	0.935	-3.81e-01	-6.14e-01	-4.49e-01	-2.58e-01	-2.05e-01	0.205000	1.06e-01	9.16e-03	5.69e-02	2.74e-01	3.84e-01	3.84e-01
Defective LFNG causes SCDO3	5	3.07e-02	5.81e-02	0.933	2.43e-02	1.59e-01	3.70e-01	6.02e-01	5.43e-01	0.229000	9.25e-01	5.39e-01	1.52e-01	1.98e-02	3.56e-02	3.76e-01
Maturation of spike protein 9683686	5	4.13e-02	7.42e-02	0.933	-2.46e-01	-5.58e-01	-3.66e-01	3.98e-01	-2.73e-01	-0.362000	3.40e-01	3.06e-02	1.56e-01	1.24e-01	2.90e-01	1.61e-01
Mitotic Telophase/Cytokinesis	13	1.35e-05	6.29e-05	0.932	-2.01e-01	3.40e-01	4.52e-01	4.16e-01	1.27e-01	0.565000	2.09e-01	3.37e-02	4.75e-03	9.40e-03	4.29e-01	4.23e-04
Butyrophilin (BTN) family interactions	9	1.39e-02	2.97e-02	0.930	1.45e-01	1.01e-01	-5.62e-01	-4.98e-03	2.58e-01	-0.672000	4.51e-01	5.99e-01	3.53e-03	9.79e-01	1.80e-01	4.83e-04
Synthesis of diphthamide-EEF2	8	3.52e-02	6.53e-02	0.927	-1.16e-01	-5.21e-01	-6.35e-01	-7.15e-02	-1.07e-01	-0.393000	5.69e-01	1.07e-02	1.86e-03	7.26e-01	6.01e-01	5.42e-02
Mitochondrial calcium ion transport	22	3.60e-06	1.88e-05	0.924	-3.99e-01	-6.95e-01	-3.93e-01	-1.16e-01	-1.69e-01	-0.117000	1.18e-03	1.62e-08	1.41e-03	3.47e-01	1.69e-01	3.42e-01
Scavenging of heme from plasma	69	7.07e-36	2.51e-34	0.923	4.40e-02	-5.23e-01	2.23e-01	3.72e-01	-4.59e-01	0.422000	5.27e-01	5.58e-14	1.35e-03	8.74e-08	4.24e-11	1.39e-09
Classical antibody-mediated complement activation	68	5.87e-36	2.13e-34	0.923	1.25e-02	-5.55e-01	1.99e-01	3.86e-01	-4.64e-01	0.375000	8.59e-01	2.48e-15	4.64e-03	3.66e-08	3.52e-11	9.07e-08
ATF6 (ATF6-alpha) activates chaperones	12	1.27e-04	4.87e-04	0.922	-5.09e-01	-4.46e-01	2.42e-01	8.19e-02	-4.84e-01	0.304000	2.25e-03	7.51e-03	1.47e-01	6.23e-01	3.66e-03	6.78e-02
Inhibition of Signaling by Overexpressed EGFR	5	2.24e-04	7.98e-04	0.922	-2.91e-01	3.69e-01	7.56e-01	-1.10e-01	7.79e-02	-0.202000	2.60e-01	1.53e-01	3.43e-03	6.71e-01	7.63e-01	4.33e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	2.24e-04	7.98e-04	0.922	-2.91e-01	3.69e-01	7.56e-01	-1.10e-01	7.79e-02	-0.202000	2.60e-01	1.53e-01	3.43e-03	6.71e-01	7.63e-01	4.33e-01
Establishment of Sister Chromatid Cohesion	11	7.22e-05	2.91e-04	0.921	-4.11e-01	1.70e-01	3.48e-01	2.33e-01	-1.66e-02	0.689000	1.82e-02	3.28e-01	4.56e-02	1.80e-01	9.24e-01	7.51e-05
Formation of the active cofactor, UDP-glucuronate	5	1.61e-01	2.23e-01	0.920	-4.25e-01	-4.52e-01	2.03e-01	-2.28e-02	-4.77e-01	0.438000	9.97e-02	7.99e-02	4.32e-01	9.30e-01	6.48e-02	9.00e-02
Translation	292	4.03e-116	7.73e-113	0.918	-2.25e-01	-7.30e-01	-4.94e-01	-5.38e-03	-8.70e-02	-0.088300	3.78e-11	2.42e-103	5.32e-48	8.74e-01	1.06e-02	9.45e-03
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	3.69e-03	9.59e-03	0.915	-2.67e-01	-1.42e-01	-1.48e-01	4.39e-01	3.78e-01	-0.623000	3.00e-01	5.83e-01	5.66e-01	8.94e-02	1.44e-01	1.58e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	1.42e-01	2.02e-01	0.914	-4.82e-01	-5.66e-01	-5.06e-01	8.58e-02	1.43e-01	0.010100	6.18e-02	2.85e-02	5.02e-02	7.40e-01	5.80e-01	9.69e-01
Interleukin-6 signaling	10	4.63e-04	1.53e-03	0.912	-2.19e-01	4.70e-01	3.35e-01	2.61e-01	1.63e-01	0.597000	2.30e-01	1.01e-02	6.65e-02	1.53e-01	3.72e-01	1.09e-03
ATF6 (ATF6-alpha) activates chaperone genes	10	4.78e-04	1.57e-03	0.912	-4.65e-01	-4.35e-01	3.04e-01	1.16e-01	-5.05e-01	0.255000	1.08e-02	1.73e-02	9.63e-02	5.24e-01	5.70e-03	1.63e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.62e-42	1.17e-40	0.911	-1.80e-01	-6.92e-01	-5.38e-01	-8.89e-03	-1.57e-02	-0.172000	9.48e-04	4.40e-37	4.52e-23	8.70e-01	7.74e-01	1.58e-03
Nonsense-Mediated Decay (NMD)	113	2.62e-42	1.17e-40	0.911	-1.80e-01	-6.92e-01	-5.38e-01	-8.89e-03	-1.57e-02	-0.172000	9.48e-04	4.40e-37	4.52e-23	8.70e-01	7.74e-01	1.58e-03
Biosynthesis of Lipoxins (LX)	6	1.04e-01	1.58e-01	0.910	2.53e-02	-1.81e-02	5.19e-01	-4.22e-01	-5.97e-01	0.149000	9.14e-01	9.39e-01	2.76e-02	7.34e-02	1.13e-02	5.26e-01
Defective GALNT3 causes HFTC	8	6.39e-02	1.06e-01	0.906	3.90e-01	5.13e-01	5.86e-01	1.00e-01	8.67e-02	0.209000	5.59e-02	1.19e-02	4.08e-03	6.24e-01	6.71e-01	3.05e-01
Synthesis of PI	5	1.92e-01	2.58e-01	0.902	3.60e-01	4.73e-01	1.82e-01	3.09e-01	5.23e-01	-0.240000	1.63e-01	6.67e-02	4.81e-01	2.31e-01	4.29e-02	3.53e-01
tRNA processing in the mitochondrion	24	1.86e-07	1.18e-06	0.901	-2.17e-01	-6.31e-01	-1.27e-01	-8.49e-02	-5.72e-01	-0.133000	6.62e-02	8.81e-08	2.81e-01	4.72e-01	1.25e-06	2.60e-01
HDMs demethylate histones	22	4.32e-09	3.48e-08	0.900	9.52e-02	6.18e-01	3.55e-01	4.90e-01	2.19e-01	0.071900	4.40e-01	5.22e-07	3.91e-03	6.98e-05	7.50e-02	5.59e-01
Processing of SMDT1	15	1.56e-04	5.85e-04	0.900	-3.45e-01	-6.75e-01	-4.68e-01	-1.03e-01	3.64e-02	-0.062800	2.06e-02	5.96e-06	1.69e-03	4.92e-01	8.07e-01	6.74e-01
Packaging Of Telomere Ends	18	4.59e-06	2.33e-05	0.900	-2.61e-01	-6.94e-01	9.38e-02	-3.12e-03	-4.16e-01	0.279000	5.49e-02	3.40e-07	4.91e-01	9.82e-01	2.26e-03	4.06e-02
Major pathway of rRNA processing in the nucleolus and cytosol	178	4.90e-63	7.23e-61	0.899	-1.60e-01	-6.74e-01	-5.20e-01	-4.19e-03	-8.05e-02	-0.225000	2.26e-04	1.56e-54	3.89e-33	9.23e-01	6.39e-02	2.18e-07
Defects of platelet adhesion to exposed collagen	6	6.10e-03	1.47e-02	0.898	4.64e-01	-5.06e-01	2.37e-01	-1.24e-01	-5.12e-01	0.027300	4.89e-02	3.17e-02	3.14e-01	5.99e-01	2.98e-02	9.08e-01
Maturation of protein 3a 9683673	9	1.71e-02	3.51e-02	0.896	1.47e-01	9.81e-02	4.57e-01	4.10e-01	1.41e-01	0.612000	4.46e-01	6.10e-01	1.75e-02	3.31e-02	4.64e-01	1.47e-03
Maturation of protein 3a 9694719	9	1.71e-02	3.51e-02	0.896	1.47e-01	9.81e-02	4.57e-01	4.10e-01	1.41e-01	0.612000	4.46e-01	6.10e-01	1.75e-02	3.31e-02	4.64e-01	1.47e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	5.11e-03	1.27e-02	0.892	-5.85e-01	-4.20e-01	9.16e-02	-5.24e-02	-4.56e-01	0.240000	1.35e-03	2.14e-02	6.16e-01	7.74e-01	1.25e-02	1.89e-01
rRNA processing in the nucleus and cytosol	188	4.10e-65	7.15e-63	0.892	-1.65e-01	-6.66e-01	-5.17e-01	-1.23e-04	-8.25e-02	-0.224000	9.46e-05	3.87e-56	1.57e-34	9.98e-01	5.11e-02	1.20e-07
NFE2L2 regulates pentose phosphate pathway genes	8	3.70e-03	9.59e-03	0.891	-8.64e-02	2.55e-01	7.04e-01	9.63e-02	-4.10e-01	0.218000	6.72e-01	2.11e-01	5.64e-04	6.37e-01	4.44e-02	2.85e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.29e-01	1.87e-01	0.889	-1.62e-01	-6.23e-01	-5.86e-01	1.74e-01	2.22e-02	-0.045000	5.30e-01	1.58e-02	2.33e-02	5.00e-01	9.31e-01	8.62e-01
APOBEC3G mediated resistance to HIV-1 infection	5	9.17e-02	1.42e-01	0.889	1.46e-01	-3.54e-01	-5.29e-01	4.54e-01	3.96e-01	0.023200	5.72e-01	1.70e-01	4.05e-02	7.85e-02	1.25e-01	9.29e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	3.37e-02	6.28e-02	0.884	1.29e-01	3.22e-01	1.52e-01	7.05e-01	3.60e-01	0.108000	5.54e-01	1.41e-01	4.85e-01	1.24e-03	9.91e-02	6.21e-01
NADE modulates death signalling	5	1.48e-01	2.07e-01	0.881	-4.30e-01	-5.31e-01	5.37e-02	7.95e-02	-3.28e-01	0.440000	9.60e-02	3.99e-02	8.35e-01	7.58e-01	2.04e-01	8.81e-02
RHOT1 GTPase cycle	5	2.38e-01	3.07e-01	0.881	-7.36e-02	-1.58e-01	5.65e-01	-1.84e-01	-5.49e-01	0.303000	7.76e-01	5.40e-01	2.86e-02	4.75e-01	3.36e-02	2.41e-01
Zygotic genome activation (ZGA)	5	9.21e-02	1.43e-01	0.880	3.17e-01	5.41e-01	2.25e-01	4.56e-01	1.47e-01	-0.319000	2.20e-01	3.62e-02	3.84e-01	7.72e-02	5.69e-01	2.17e-01
Signal attenuation	9	4.78e-03	1.20e-02	0.877	-3.08e-01	-2.05e-01	4.76e-01	-4.01e-01	-4.95e-01	-0.021100	1.10e-01	2.86e-01	1.34e-02	3.73e-02	1.01e-02	9.13e-01
Cellular response to mitochondrial stress	9	8.92e-03	2.02e-02	0.877	-4.61e-01	-6.15e-01	-2.52e-01	-1.71e-01	-3.11e-02	0.292000	1.67e-02	1.40e-03	1.91e-01	3.75e-01	8.72e-01	1.29e-01
rRNA processing	212	1.31e-71	5.03e-69	0.874	-1.52e-01	-6.68e-01	-4.84e-01	-6.23e-03	-1.24e-01	-0.211000	1.39e-04	1.61e-63	4.35e-34	8.76e-01	1.81e-03	1.27e-07
p130Cas linkage to MAPK signaling for integrins	11	8.12e-03	1.88e-02	0.873	-3.73e-01	-5.79e-01	1.61e-01	-2.16e-01	-3.87e-01	0.255000	3.23e-02	8.82e-04	3.56e-01	2.14e-01	2.61e-02	1.43e-01
Branched-chain ketoacid dehydrogenase kinase deficiency	5	2.72e-01	3.41e-01	0.872	-6.32e-01	-2.97e-01	-2.63e-01	-2.79e-01	-3.52e-01	-0.039700	1.44e-02	2.49e-01	3.08e-01	2.80e-01	1.73e-01	8.78e-01
Condensation of Prometaphase Chromosomes	11	5.61e-04	1.79e-03	0.871	5.11e-03	-3.38e-01	2.90e-01	3.95e-01	-2.90e-01	0.565000	9.77e-01	5.19e-02	9.56e-02	2.34e-02	9.62e-02	1.16e-03
ROBO receptors bind AKAP5	7	3.25e-02	6.11e-02	0.867	-1.16e-01	2.30e-01	2.68e-01	3.03e-01	4.07e-01	0.597000	5.95e-01	2.92e-01	2.20e-01	1.65e-01	6.21e-02	6.20e-03
Recycling of bile acids and salts	8	5.41e-02	9.27e-02	0.866	1.93e-01	4.36e-01	3.49e-01	4.92e-01	3.60e-01	0.174000	3.44e-01	3.28e-02	8.75e-02	1.60e-02	7.78e-02	3.95e-01
RUNX1 regulates transcription of genes involved in WNT signaling	5	1.36e-01	1.95e-01	0.866	4.26e-01	4.29e-01	3.51e-01	3.42e-01	-1.95e-01	0.325000	9.93e-02	9.67e-02	1.74e-01	1.85e-01	4.50e-01	2.08e-01
Estrogen-stimulated signaling through PRKCZ	6	9.78e-02	1.50e-01	0.864	-5.68e-01	-2.90e-01	4.89e-02	-1.16e-01	-5.18e-01	0.237000	1.60e-02	2.19e-01	8.36e-01	6.22e-01	2.81e-02	3.14e-01
Creation of C4 and C2 activators	70	3.70e-32	1.16e-30	0.862	9.51e-04	-5.26e-01	1.70e-01	3.63e-01	-4.29e-01	0.347000	9.89e-01	2.54e-14	1.37e-02	1.44e-07	5.49e-10	5.14e-07
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	5.70e-06	2.87e-05	0.861	-1.41e-01	-5.78e-01	2.52e-01	-1.51e-01	-4.77e-01	0.273000	2.76e-01	7.56e-06	5.11e-02	2.43e-01	2.24e-04	3.44e-02
Apoptosis induced DNA fragmentation	10	3.23e-02	6.07e-02	0.861	-5.00e-01	-5.08e-01	-4.30e-02	-2.17e-01	-3.27e-01	0.277000	6.14e-03	5.37e-03	8.14e-01	2.35e-01	7.30e-02	1.30e-01
FCGR activation	75	4.26e-34	1.41e-32	0.859	3.04e-02	-4.28e-01	1.94e-01	3.69e-01	-4.10e-01	0.459000	6.49e-01	1.47e-10	3.70e-03	3.14e-08	8.00e-10	6.00e-12
Arachidonate production from DAG	5	1.43e-01	2.02e-01	0.858	-4.39e-02	-7.38e-01	-3.40e-01	9.80e-02	-1.47e-01	-0.209000	8.65e-01	4.28e-03	1.88e-01	7.04e-01	5.70e-01	4.19e-01
NFE2L2 regulating MDR associated enzymes	8	1.31e-02	2.84e-02	0.858	4.11e-01	2.35e-01	4.74e-01	4.91e-01	-2.11e-01	0.042300	4.39e-02	2.49e-01	2.02e-02	1.62e-02	3.02e-01	8.36e-01
Phenylalanine metabolism	5	1.46e-01	2.06e-01	0.858	8.41e-02	-1.55e-01	-5.24e-01	-7.19e-02	5.11e-01	-0.405000	7.45e-01	5.49e-01	4.26e-02	7.81e-01	4.78e-02	1.17e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	4.20e-02	7.51e-02	0.856	-4.10e-01	-3.81e-01	4.86e-02	-3.88e-01	-3.11e-01	0.413000	3.32e-02	4.79e-02	8.01e-01	4.39e-02	1.06e-01	3.19e-02
TGFBR3 expression	20	7.41e-06	3.63e-05	0.856	7.87e-02	5.84e-01	1.50e-01	4.11e-01	4.06e-01	0.171000	5.42e-01	6.17e-06	2.45e-01	1.44e-03	1.66e-03	1.87e-01
Scavenging by Class F Receptors	5	1.18e-01	1.74e-01	0.853	1.47e-03	2.00e-02	4.89e-01	5.16e-01	7.26e-02	0.466000	9.95e-01	9.38e-01	5.84e-02	4.58e-02	7.78e-01	7.11e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	7.85e-04	2.41e-03	0.853	-2.29e-01	5.33e-01	2.56e-01	2.16e-01	2.09e-01	0.484000	2.10e-01	3.52e-03	1.60e-01	2.36e-01	2.52e-01	8.04e-03
MASTL Facilitates Mitotic Progression	10	6.10e-03	1.47e-02	0.852	-4.79e-01	-3.88e-01	1.40e-01	6.19e-02	-2.95e-01	0.485000	8.75e-03	3.35e-02	4.43e-01	7.35e-01	1.07e-01	7.88e-03
Disorders of Developmental Biology	12	4.65e-03	1.17e-02	0.852	1.66e-01	3.28e-01	1.92e-01	6.16e-01	3.58e-01	0.215000	3.19e-01	4.94e-02	2.50e-01	2.19e-04	3.18e-02	1.98e-01
Disorders of Nervous System Development	12	4.65e-03	1.17e-02	0.852	1.66e-01	3.28e-01	1.92e-01	6.16e-01	3.58e-01	0.215000	3.19e-01	4.94e-02	2.50e-01	2.19e-04	3.18e-02	1.98e-01
Loss of function of MECP2 in Rett syndrome	12	4.65e-03	1.17e-02	0.852	1.66e-01	3.28e-01	1.92e-01	6.16e-01	3.58e-01	0.215000	3.19e-01	4.94e-02	2.50e-01	2.19e-04	3.18e-02	1.98e-01
Pervasive developmental disorders	12	4.65e-03	1.17e-02	0.852	1.66e-01	3.28e-01	1.92e-01	6.16e-01	3.58e-01	0.215000	3.19e-01	4.94e-02	2.50e-01	2.19e-04	3.18e-02	1.98e-01
Acetylcholine Neurotransmitter Release Cycle	10	7.32e-03	1.73e-02	0.852	2.80e-01	2.13e-01	2.24e-02	4.24e-01	5.76e-01	-0.299000	1.25e-01	2.44e-01	9.02e-01	2.03e-02	1.61e-03	1.01e-01
Neurotransmitter clearance	5	1.29e-01	1.87e-01	0.849	-1.32e-01	-1.86e-01	-2.06e-01	-1.91e-01	-3.60e-01	-0.679000	6.10e-01	4.71e-01	4.25e-01	4.60e-01	1.63e-01	8.56e-03
Influenza Viral RNA Transcription and Replication	134	1.16e-41	5.04e-40	0.849	-1.96e-01	-6.13e-01	-5.15e-01	4.75e-02	3.77e-02	-0.198000	9.03e-05	1.44e-34	7.06e-25	3.43e-01	4.52e-01	7.69e-05
rRNA processing in the mitochondrion	24	1.84e-07	1.17e-06	0.849	-4.59e-02	-6.76e-01	-2.18e-01	-5.36e-02	-4.47e-01	-0.103000	6.97e-01	9.73e-09	6.46e-02	6.50e-01	1.49e-04	3.82e-01
SMAC (DIABLO) binds to IAPs	7	1.97e-02	3.96e-02	0.847	-4.54e-01	-3.05e-01	8.00e-03	-3.68e-02	7.71e-02	0.641000	3.74e-02	1.62e-01	9.71e-01	8.66e-01	7.24e-01	3.32e-03
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	1.97e-02	3.96e-02	0.847	-4.54e-01	-3.05e-01	8.00e-03	-3.68e-02	7.71e-02	0.641000	3.74e-02	1.62e-01	9.71e-01	8.66e-01	7.24e-01	3.32e-03
SMAC, XIAP-regulated apoptotic response	7	1.97e-02	3.96e-02	0.847	-4.54e-01	-3.05e-01	8.00e-03	-3.68e-02	7.71e-02	0.641000	3.74e-02	1.62e-01	9.71e-01	8.66e-01	7.24e-01	3.32e-03
H139Hfs13* PPM1K causes a mild variant of MSUD	5	1.86e-01	2.51e-01	0.847	-5.58e-01	-2.16e-01	-3.65e-01	-3.92e-01	-2.24e-01	0.150000	3.08e-02	4.03e-01	1.58e-01	1.29e-01	3.87e-01	5.62e-01
Maple Syrup Urine Disease	5	1.86e-01	2.51e-01	0.847	-5.58e-01	-2.16e-01	-3.65e-01	-3.92e-01	-2.24e-01	0.150000	3.08e-02	4.03e-01	1.58e-01	1.29e-01	3.87e-01	5.62e-01
Miscellaneous substrates	7	6.55e-02	1.08e-01	0.846	5.42e-01	5.10e-01	3.07e-01	-2.61e-02	1.51e-01	-0.209000	1.30e-02	1.94e-02	1.60e-01	9.05e-01	4.88e-01	3.38e-01
Platelet sensitization by LDL	16	2.72e-05	1.21e-04	0.845	-4.24e-01	2.15e-01	4.40e-01	-4.46e-02	-1.22e-01	0.527000	3.29e-03	1.37e-01	2.32e-03	7.57e-01	4.00e-01	2.61e-04
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	7.51e-05	3.02e-04	0.845	-1.35e-01	3.87e-02	1.90e-01	5.95e-01	5.18e-01	-0.188000	5.09e-01	8.50e-01	3.52e-01	3.56e-03	1.12e-02	3.57e-01
EGFR interacts with phospholipase C-gamma	6	4.85e-04	1.59e-03	0.844	-1.18e-01	4.32e-01	6.57e-01	3.82e-03	1.74e-01	-0.224000	6.16e-01	6.70e-02	5.28e-03	9.87e-01	4.61e-01	3.43e-01
SUMO is proteolytically processed	6	3.14e-02	5.92e-02	0.843	-6.45e-01	-1.99e-01	-1.86e-01	6.27e-02	1.14e-01	0.451000	6.18e-03	3.98e-01	4.30e-01	7.90e-01	6.30e-01	5.56e-02
Translocation of ZAP-70 to Immunological synapse	24	3.62e-06	1.88e-05	0.843	1.76e-01	6.46e-02	-4.47e-01	3.40e-01	5.89e-01	-0.121000	1.35e-01	5.84e-01	1.52e-04	3.98e-03	5.98e-07	3.05e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	9.13e-02	1.42e-01	0.841	1.71e-01	3.73e-01	2.52e-01	5.51e-01	4.03e-01	0.094000	4.33e-01	8.72e-02	2.49e-01	1.16e-02	6.49e-02	6.67e-01
Sulfide oxidation to sulfate	5	1.97e-01	2.63e-01	0.838	-1.17e-01	-6.00e-01	-4.78e-01	7.33e-02	1.81e-01	-0.250000	6.50e-01	2.02e-02	6.41e-02	7.77e-01	4.84e-01	3.32e-01
Eicosanoids	6	4.56e-02	8.00e-02	0.836	-2.38e-03	1.29e-01	4.93e-01	-6.29e-01	-1.63e-01	0.133000	9.92e-01	5.85e-01	3.66e-02	7.63e-03	4.89e-01	5.74e-01
Glucuronidation	8	8.05e-02	1.28e-01	0.834	-3.27e-01	-4.78e-01	1.85e-01	-1.11e-01	-4.18e-01	0.374000	1.09e-01	1.93e-02	3.64e-01	5.87e-01	4.06e-02	6.72e-02
Mitochondrial protein import	63	2.08e-17	3.36e-16	0.832	-2.14e-01	-6.40e-01	-4.52e-01	-3.33e-02	-8.99e-02	-0.154000	3.35e-03	1.49e-18	5.55e-10	6.48e-01	2.17e-01	3.48e-02
Regulation of TP53 Activity through Association with Co-factors	11	6.83e-04	2.14e-03	0.830	3.00e-02	2.34e-01	-2.32e-01	4.19e-01	2.31e-01	-0.593000	8.63e-01	1.79e-01	1.83e-01	1.62e-02	1.84e-01	6.62e-04
DNA methylation	18	9.32e-06	4.47e-05	0.830	-6.08e-02	-5.71e-01	2.91e-01	-1.30e-02	-3.84e-01	0.356000	6.55e-01	2.70e-05	3.25e-02	9.24e-01	4.80e-03	9.02e-03
MET activates RAP1 and RAC1	10	3.79e-03	9.76e-03	0.825	-4.31e-01	1.30e-01	3.12e-01	-1.81e-01	-4.92e-01	0.324000	1.83e-02	4.77e-01	8.73e-02	3.21e-01	7.05e-03	7.62e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.32e-02	2.86e-02	0.824	-2.00e-01	-6.09e-01	-4.81e-01	4.99e-02	2.99e-02	-0.181000	2.51e-01	4.67e-04	5.70e-03	7.75e-01	8.63e-01	2.99e-01
rRNA modification in the mitochondrion	8	1.84e-03	5.19e-03	0.824	1.48e-01	-4.82e-01	-6.37e-01	1.34e-01	-9.44e-03	0.002270	4.69e-01	1.82e-02	1.80e-03	5.10e-01	9.63e-01	9.91e-01
Vitamin B1 (thiamin) metabolism	5	3.89e-01	4.54e-01	0.823	-4.07e-01	-4.04e-01	-5.13e-01	-7.69e-02	-1.54e-01	-0.237000	1.15e-01	1.18e-01	4.69e-02	7.66e-01	5.50e-01	3.60e-01
STAT3 nuclear events downstream of ALK signaling	11	1.75e-02	3.56e-02	0.822	1.36e-01	3.88e-01	2.38e-01	4.89e-01	4.15e-01	0.196000	4.35e-01	2.60e-02	1.71e-01	4.97e-03	1.70e-02	2.61e-01
Interleukin-20 family signaling	17	3.89e-04	1.30e-03	0.821	9.51e-02	3.81e-01	2.91e-01	3.78e-01	2.28e-01	0.489000	4.97e-01	6.60e-03	3.75e-02	6.94e-03	1.03e-01	4.77e-04
Role of LAT2/NTAL/LAB on calcium mobilization	76	3.73e-30	1.07e-28	0.820	6.65e-03	-3.90e-01	2.24e-01	3.20e-01	-4.18e-01	0.440000	9.20e-01	4.26e-09	7.48e-04	1.39e-06	2.94e-10	3.31e-11
PINK1-PRKN Mediated Mitophagy	31	5.62e-08	3.83e-07	0.814	-3.06e-01	-5.54e-01	-2.57e-01	-1.90e-01	-3.56e-01	0.182000	3.15e-03	9.16e-08	1.34e-02	6.74e-02	6.07e-04	7.93e-02
Processing and activation of SUMO	10	3.73e-03	9.64e-03	0.813	-5.26e-01	-4.00e-01	-3.58e-01	1.15e-01	-4.21e-02	0.284000	3.97e-03	2.86e-02	4.97e-02	5.28e-01	8.18e-01	1.20e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	8.56e-02	1.34e-01	0.812	3.52e-02	3.70e-01	4.61e-01	-2.18e-01	1.66e-01	0.483000	8.72e-01	9.03e-02	3.46e-02	3.17e-01	4.46e-01	2.68e-02
Ethanol oxidation	6	1.92e-01	2.57e-01	0.812	-3.40e-01	-2.37e-01	-5.67e-01	1.65e-01	9.93e-02	-0.358000	1.49e-01	3.15e-01	1.62e-02	4.84e-01	6.74e-01	1.28e-01
Regulation of PTEN localization	9	6.55e-02	1.08e-01	0.811	-3.31e-01	-4.51e-01	1.45e-01	-2.02e-01	-3.39e-01	0.409000	8.52e-02	1.91e-02	4.51e-01	2.95e-01	7.79e-02	3.35e-02
Regulation of expression of SLITs and ROBOs	148	5.78e-46	3.17e-44	0.809	-2.07e-01	-6.69e-01	-3.95e-01	-3.67e-02	-6.19e-02	-0.050700	1.40e-05	4.85e-45	1.10e-16	4.40e-01	1.94e-01	2.87e-01
tRNA modification in the mitochondrion	9	5.02e-02	8.67e-02	0.803	-1.50e-01	-5.87e-01	-3.75e-01	-9.81e-02	-7.33e-02	-0.351000	4.37e-01	2.30e-03	5.15e-02	6.10e-01	7.03e-01	6.83e-02
SLBP independent Processing of Histone Pre-mRNAs	10	3.64e-02	6.70e-02	0.802	-2.48e-01	-5.77e-01	-4.61e-01	-1.95e-02	5.18e-02	-0.182000	1.75e-01	1.58e-03	1.15e-02	9.15e-01	7.77e-01	3.18e-01
Cytosolic iron-sulfur cluster assembly	13	1.30e-03	3.78e-03	0.802	1.27e-01	-3.72e-01	-3.34e-01	2.95e-01	1.59e-01	-0.515000	4.29e-01	2.04e-02	3.71e-02	6.60e-02	3.20e-01	1.32e-03
Defective CFTR causes cystic fibrosis	47	2.44e-14	3.28e-13	0.800	-3.28e-01	-5.71e-01	8.59e-02	-1.29e-02	-2.05e-01	0.397000	9.99e-05	1.25e-11	3.08e-01	8.78e-01	1.51e-02	2.47e-06
SIRT1 negatively regulates rRNA expression	22	6.24e-05	2.56e-04	0.799	-2.29e-01	-6.11e-01	-5.84e-03	-1.87e-01	-4.09e-01	0.103000	6.27e-02	6.97e-07	9.62e-01	1.30e-01	9.01e-04	4.02e-01
Defective HLCS causes multiple carboxylase deficiency	7	1.22e-01	1.79e-01	0.797	-2.45e-01	-3.32e-01	-4.84e-01	2.84e-01	3.17e-01	-0.222000	2.61e-01	1.29e-01	2.66e-02	1.93e-01	1.46e-01	3.10e-01
Phosphate bond hydrolysis by NTPDase proteins	5	7.76e-02	1.24e-01	0.796	-7.07e-01	4.00e-03	-3.18e-01	2.36e-02	1.58e-01	0.082200	6.18e-03	9.88e-01	2.18e-01	9.27e-01	5.40e-01	7.50e-01
Regulation of RUNX1 Expression and Activity	18	3.74e-04	1.26e-03	0.793	1.77e-02	4.15e-01	3.41e-01	2.36e-01	2.00e-01	0.494000	8.97e-01	2.31e-03	1.22e-02	8.26e-02	1.43e-01	2.81e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	8.28e-13	9.69e-12	0.791	-2.34e-01	-6.21e-01	6.09e-02	7.78e-03	-1.71e-01	0.390000	1.15e-02	1.91e-11	5.11e-01	9.33e-01	6.52e-02	2.50e-05
p53-Independent DNA Damage Response	39	8.28e-13	9.69e-12	0.791	-2.34e-01	-6.21e-01	6.09e-02	7.78e-03	-1.71e-01	0.390000	1.15e-02	1.91e-11	5.11e-01	9.33e-01	6.52e-02	2.50e-05
p53-Independent G1/S DNA damage checkpoint	39	8.28e-13	9.69e-12	0.791	-2.34e-01	-6.21e-01	6.09e-02	7.78e-03	-1.71e-01	0.390000	1.15e-02	1.91e-11	5.11e-01	9.33e-01	6.52e-02	2.50e-05
GDP-fucose biosynthesis	6	1.63e-01	2.25e-01	0.789	-5.02e-02	-4.73e-01	-3.77e-01	2.08e-01	8.35e-02	-0.451000	8.31e-01	4.48e-02	1.10e-01	3.77e-01	7.23e-01	5.56e-02
NRIF signals cell death from the nucleus	15	6.20e-03	1.49e-02	0.788	-4.49e-01	-5.07e-01	-2.35e-01	-6.52e-02	-3.21e-01	-0.003970	2.60e-03	6.69e-04	1.15e-01	6.62e-01	3.12e-02	9.79e-01
Cristae formation	33	5.02e-09	4.01e-08	0.788	-2.06e-01	-7.00e-01	-2.38e-01	-1.17e-02	-1.77e-01	0.021800	4.05e-02	3.30e-12	1.79e-02	9.07e-01	7.78e-02	8.29e-01
LTC4-CYSLTR mediated IL4 production	5	1.06e-01	1.60e-01	0.788	-2.60e-01	-5.03e-02	-8.12e-02	2.74e-01	5.72e-01	0.377000	3.14e-01	8.46e-01	7.53e-01	2.88e-01	2.68e-02	1.44e-01
Polo-like kinase mediated events	16	7.04e-05	2.85e-04	0.788	1.59e-01	-2.99e-01	3.38e-01	4.25e-01	-1.91e-01	0.418000	2.70e-01	3.86e-02	1.92e-02	3.27e-03	1.87e-01	3.80e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.08e-02	2.39e-02	0.787	-3.51e-01	-4.77e-01	2.19e-01	-2.39e-01	-2.86e-01	0.288000	3.52e-02	4.23e-03	1.90e-01	1.52e-01	8.64e-02	8.44e-02
Influenza Infection	153	3.61e-40	1.51e-38	0.786	-2.13e-01	-5.62e-01	-4.78e-01	5.66e-02	2.35e-02	-0.157000	5.29e-06	2.85e-33	1.63e-24	2.27e-01	6.16e-01	8.05e-04
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	3.73e-03	9.64e-03	0.784	-4.79e-01	-4.45e-01	6.36e-02	-1.83e-01	-2.83e-01	0.264000	9.04e-04	2.05e-03	6.60e-01	2.05e-01	5.01e-02	6.70e-02
Regulation of ornithine decarboxylase (ODC)	38	2.43e-11	2.52e-10	0.783	-2.91e-01	-5.71e-01	9.84e-02	-5.32e-02	-1.77e-01	0.399000	1.88e-03	1.11e-09	2.94e-01	5.71e-01	5.84e-02	2.11e-05
Interleukin-2 signaling	11	1.64e-02	3.41e-02	0.783	2.08e-01	4.08e-01	2.08e-01	5.24e-01	1.65e-01	0.241000	2.32e-01	1.92e-02	2.33e-01	2.62e-03	3.44e-01	1.66e-01
Hh mutants are degraded by ERAD	42	3.13e-12	3.45e-11	0.781	-2.83e-01	-5.68e-01	8.41e-02	1.21e-02	-2.15e-01	0.392000	1.50e-03	1.84e-10	3.46e-01	8.92e-01	1.58e-02	1.11e-05
Alpha-oxidation of phytanate	6	1.99e-01	2.65e-01	0.781	-3.81e-01	-5.08e-01	-3.71e-01	-2.17e-01	1.26e-01	-0.073900	1.06e-01	3.12e-02	1.15e-01	3.57e-01	5.94e-01	7.54e-01
RUNX1 regulates expression of components of tight junctions	5	3.26e-01	3.93e-01	0.780	4.82e-02	1.22e-01	3.64e-01	-3.60e-01	-4.86e-01	0.306000	8.52e-01	6.38e-01	1.58e-01	1.64e-01	5.99e-02	2.37e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	5.11e-11	5.03e-10	0.780	-2.64e-01	-5.98e-01	5.84e-02	-3.55e-02	-1.87e-01	0.376000	5.39e-03	3.05e-10	5.39e-01	7.09e-01	4.88e-02	7.63e-05
Vif-mediated degradation of APOBEC3G	41	1.22e-12	1.40e-11	0.779	-2.38e-01	-6.13e-01	1.61e-02	4.30e-03	-1.84e-01	0.375000	8.29e-03	1.06e-11	8.58e-01	9.62e-01	4.17e-02	3.29e-05
Assembly of the ORC complex at the origin of replication	23	5.93e-05	2.46e-04	0.778	-2.85e-01	-5.30e-01	3.62e-02	-1.69e-01	-3.38e-01	0.316000	1.78e-02	1.09e-05	7.64e-01	1.62e-01	5.07e-03	8.61e-03
Defects in biotin (Btn) metabolism	8	1.17e-01	1.73e-01	0.777	-2.28e-01	-2.37e-01	-5.31e-01	1.73e-01	3.68e-01	-0.220000	2.65e-01	2.46e-01	9.24e-03	3.96e-01	7.17e-02	2.81e-01
Binding and Uptake of Ligands by Scavenger Receptors	89	8.03e-32	2.48e-30	0.776	-1.28e-02	-4.66e-01	2.32e-01	2.90e-01	-3.73e-01	0.328000	8.35e-01	2.91e-14	1.56e-04	2.19e-06	1.18e-09	8.96e-08
NFE2L2 regulating tumorigenic genes	11	6.87e-03	1.64e-02	0.775	3.05e-01	2.77e-01	5.39e-01	2.86e-01	-2.35e-01	0.052800	7.96e-02	1.12e-01	1.95e-03	1.00e-01	1.77e-01	7.62e-01
Termination of O-glycan biosynthesis	15	1.64e-02	3.41e-02	0.775	3.09e-01	2.72e-01	5.04e-01	2.27e-01	5.69e-02	0.349000	3.81e-02	6.84e-02	7.23e-04	1.28e-01	7.03e-01	1.91e-02
Cytochrome c-mediated apoptotic response	13	3.84e-03	9.87e-03	0.774	-5.41e-01	-3.38e-01	-1.45e-01	-1.33e-01	-9.00e-02	0.382000	7.31e-04	3.50e-02	3.65e-01	4.08e-01	5.74e-01	1.71e-02
Processive synthesis on the lagging strand	15	1.57e-04	5.86e-04	0.773	1.35e-01	-4.57e-01	-2.94e-01	4.36e-01	3.05e-01	-0.019800	3.65e-01	2.16e-03	4.89e-02	3.46e-03	4.11e-02	8.94e-01
Cleavage of the damaged purine	21	7.69e-06	3.74e-05	0.772	-1.36e-01	-6.75e-01	-2.27e-02	6.74e-02	-3.14e-01	0.137000	2.82e-01	8.60e-08	8.57e-01	5.93e-01	1.28e-02	2.78e-01
Depurination	21	7.69e-06	3.74e-05	0.772	-1.36e-01	-6.75e-01	-2.27e-02	6.74e-02	-3.14e-01	0.137000	2.82e-01	8.60e-08	8.57e-01	5.93e-01	1.28e-02	2.78e-01
Recognition and association of DNA glycosylase with site containing an affected purine	21	7.69e-06	3.74e-05	0.772	-1.36e-01	-6.75e-01	-2.27e-02	6.74e-02	-3.14e-01	0.137000	2.82e-01	8.60e-08	8.57e-01	5.93e-01	1.28e-02	2.78e-01
Initial triggering of complement	78	5.18e-29	1.40e-27	0.770	1.76e-02	-4.92e-01	1.40e-01	3.45e-01	-3.60e-01	0.286000	7.88e-01	5.43e-14	3.31e-02	1.31e-07	3.76e-08	1.25e-05
ChREBP activates metabolic gene expression	7	7.54e-02	1.22e-01	0.769	6.78e-02	8.91e-03	4.29e-01	4.29e-01	-2.34e-01	0.405000	7.56e-01	9.67e-01	4.95e-02	4.95e-02	2.83e-01	6.35e-02
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	2.80e-01	3.49e-01	0.769	1.48e-01	8.34e-02	5.09e-01	3.12e-01	-8.70e-03	0.453000	5.30e-01	7.24e-01	3.07e-02	1.86e-01	9.71e-01	5.48e-02
Hedgehog ligand biogenesis	47	2.77e-12	3.07e-11	0.768	-2.94e-01	-5.42e-01	9.20e-02	-2.58e-02	-2.61e-01	0.362000	4.85e-04	1.24e-10	2.75e-01	7.59e-01	1.92e-03	1.72e-05
Maturation of hRSV A proteins	13	6.11e-03	1.47e-02	0.766	-3.97e-01	-3.45e-01	6.10e-02	-1.37e-02	-3.70e-01	0.411000	1.31e-02	3.14e-02	7.04e-01	9.32e-01	2.09e-02	1.02e-02
Cellular response to starvation	147	3.66e-36	1.35e-34	0.766	-1.99e-01	-6.02e-01	-3.84e-01	-7.33e-02	-9.32e-02	-0.152000	3.12e-05	1.69e-36	8.67e-16	1.25e-01	5.10e-02	1.46e-03
PI3K events in ERBB4 signaling	6	1.63e-02	3.40e-02	0.766	-3.20e-01	5.41e-01	3.04e-01	-1.59e-01	2.36e-01	-0.134000	1.75e-01	2.16e-02	1.98e-01	5.01e-01	3.17e-01	5.70e-01
Complex I biogenesis	66	3.80e-19	6.74e-18	0.766	-1.42e-01	-6.63e-01	-3.46e-01	-4.05e-02	-6.61e-02	-0.031800	4.56e-02	1.17e-20	1.16e-06	5.69e-01	3.53e-01	6.56e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	3.01e-01	3.70e-01	0.765	1.93e-01	-3.17e-03	4.21e-01	2.12e-01	1.67e-01	0.546000	4.54e-01	9.90e-01	1.03e-01	4.12e-01	5.18e-01	3.45e-02
Chromatin modifications during the maternal to zygotic transition (MZT)	23	6.63e-05	2.69e-04	0.765	-1.14e-01	-3.84e-01	2.91e-01	-7.67e-02	-5.05e-01	0.282000	3.43e-01	1.45e-03	1.57e-02	5.24e-01	2.75e-05	1.92e-02
Interaction between L1 and Ankyrins	25	2.59e-04	9.12e-04	0.765	3.19e-01	3.02e-01	4.99e-01	8.85e-02	4.29e-02	0.365000	5.78e-03	8.96e-03	1.55e-05	4.44e-01	7.11e-01	1.60e-03
Fatty acids	6	1.09e-01	1.63e-01	0.764	3.07e-01	4.28e-01	4.00e-01	-3.48e-01	1.23e-01	0.102000	1.93e-01	6.95e-02	8.94e-02	1.40e-01	6.01e-01	6.66e-01
Methionine salvage pathway	6	1.10e-01	1.65e-01	0.763	-1.48e-01	-4.76e-01	-5.01e-01	-9.79e-02	2.67e-01	-0.041800	5.30e-01	4.34e-02	3.35e-02	6.78e-01	2.57e-01	8.59e-01
rRNA modification in the nucleus and cytosol	59	1.29e-13	1.60e-12	0.762	-1.59e-01	-5.54e-01	-4.17e-01	8.39e-02	-1.58e-01	-0.206000	3.42e-02	1.83e-13	2.90e-08	2.65e-01	3.58e-02	6.14e-03
Noncanonical activation of NOTCH3	8	4.27e-02	7.62e-02	0.761	-4.88e-01	-3.72e-01	2.78e-02	9.00e-02	-3.96e-01	0.193000	1.69e-02	6.83e-02	8.92e-01	6.60e-01	5.22e-02	3.45e-01
Diseases of branched-chain amino acid catabolism	13	9.84e-03	2.19e-02	0.761	-4.57e-01	-3.88e-01	-4.47e-01	-1.22e-01	-1.47e-02	0.075500	4.35e-03	1.55e-02	5.31e-03	4.45e-01	9.27e-01	6.37e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	82	1.17e-27	2.74e-26	0.760	1.08e-01	-3.31e-01	2.37e-01	3.07e-01	-3.62e-01	0.418000	9.01e-02	2.10e-07	2.11e-04	1.51e-06	1.48e-08	5.95e-11
Common Pathway of Fibrin Clot Formation	13	3.07e-02	5.81e-02	0.759	-1.87e-01	2.55e-02	4.52e-01	-2.00e-01	-2.97e-01	0.456000	2.42e-01	8.74e-01	4.75e-03	2.12e-01	6.40e-02	4.46e-03
Repression of WNT target genes	14	2.26e-02	4.45e-02	0.759	3.78e-01	2.10e-01	3.28e-01	4.67e-01	1.69e-01	0.187000	1.43e-02	1.74e-01	3.38e-02	2.50e-03	2.75e-01	2.25e-01
Removal of the Flap Intermediate	14	2.86e-04	9.99e-04	0.758	8.90e-02	-4.93e-01	-2.61e-01	4.26e-01	2.67e-01	0.044000	5.64e-01	1.40e-03	9.13e-02	5.73e-03	8.33e-02	7.75e-01
RORA activates gene expression	18	1.68e-06	9.22e-06	0.756	-1.81e-02	5.09e-01	2.99e-01	4.53e-01	9.57e-02	0.094200	8.94e-01	1.87e-04	2.83e-02	8.65e-04	4.82e-01	4.89e-01
Regulation of Apoptosis	40	6.31e-11	6.17e-10	0.755	-2.65e-01	-5.72e-01	4.15e-02	-4.79e-02	-1.84e-01	0.367000	3.79e-03	3.83e-10	6.49e-01	6.00e-01	4.44e-02	5.89e-05
Hh mutants abrogate ligand secretion	43	2.52e-11	2.58e-10	0.755	-2.87e-01	-5.48e-01	7.07e-02	6.66e-03	-2.22e-01	0.364000	1.13e-03	4.84e-10	4.23e-01	9.40e-01	1.20e-02	3.65e-05
N-Glycan antennae elongation	12	1.80e-02	3.66e-02	0.754	8.83e-02	5.38e-02	4.76e-01	3.40e-01	-6.68e-02	0.459000	5.96e-01	7.47e-01	4.27e-03	4.12e-02	6.89e-01	5.85e-03
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	4.76e-11	4.73e-10	0.754	-6.59e-02	2.76e-01	1.28e-01	5.69e-01	3.83e-01	0.028200	5.19e-01	6.81e-03	2.09e-01	2.50e-08	1.74e-04	7.83e-01
Toxicity of botulinum toxin type D (botD)	5	4.76e-01	5.34e-01	0.753	3.21e-01	1.69e-01	-2.32e-01	2.00e-01	3.61e-01	-0.461000	2.14e-01	5.12e-01	3.69e-01	4.39e-01	1.62e-01	7.45e-02
Toxicity of botulinum toxin type F (botF)	5	4.76e-01	5.34e-01	0.753	3.21e-01	1.69e-01	-2.32e-01	2.00e-01	3.61e-01	-0.461000	2.14e-01	5.12e-01	3.69e-01	4.39e-01	1.62e-01	7.45e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	1.51e-12	1.72e-11	0.753	-2.13e-01	-5.97e-01	4.62e-02	2.36e-03	-1.43e-01	0.378000	1.85e-02	3.61e-11	6.09e-01	9.79e-01	1.14e-01	2.74e-05
RHO GTPases activate IQGAPs	25	1.66e-05	7.62e-05	0.753	-1.45e-01	-1.49e-01	5.06e-01	-2.06e-02	-3.80e-01	0.351000	2.10e-01	1.96e-01	1.19e-05	8.59e-01	9.98e-04	2.37e-03
Recycling of eIF2:GDP	8	4.13e-02	7.42e-02	0.753	-1.52e-01	-6.48e-01	-3.19e-01	-1.45e-01	-1.90e-02	0.036100	4.57e-01	1.51e-03	1.18e-01	4.77e-01	9.26e-01	8.60e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	8.71e-04	2.65e-03	0.752	-1.89e-01	-2.40e-01	3.93e-01	2.59e-01	-1.39e-01	0.481000	2.20e-01	1.20e-01	1.08e-02	9.35e-02	3.68e-01	1.84e-03
Vpu mediated degradation of CD4	39	1.91e-11	1.99e-10	0.752	-2.65e-01	-6.06e-01	4.52e-03	-6.99e-03	-1.25e-01	0.336000	4.24e-03	5.81e-11	9.61e-01	9.40e-01	1.78e-01	2.83e-04
Signaling by RNF43 mutants	7	9.73e-02	1.50e-01	0.751	3.80e-02	5.59e-01	4.52e-01	6.71e-02	-9.71e-02	0.176000	8.62e-01	1.04e-02	3.82e-02	7.59e-01	6.57e-01	4.19e-01
Regulation of CDH19 Expression and Function	5	1.73e-02	3.55e-02	0.751	-1.31e-01	4.41e-01	2.84e-01	5.94e-02	2.37e-01	-0.461000	6.11e-01	8.79e-02	2.72e-01	8.18e-01	3.59e-01	7.41e-02
Neurotoxicity of clostridium toxins	8	8.27e-02	1.31e-01	0.751	3.18e-01	2.62e-01	1.19e-01	2.84e-01	4.94e-01	-0.235000	1.19e-01	1.99e-01	5.61e-01	1.64e-01	1.55e-02	2.50e-01
Signaling by ALK	24	1.73e-04	6.36e-04	0.751	1.88e-01	3.61e-01	3.30e-01	4.26e-01	2.56e-01	0.206000	1.11e-01	2.22e-03	5.13e-03	3.03e-04	3.00e-02	8.07e-02
NFE2L2 regulating ER-stress associated genes	5	6.80e-02	1.11e-01	0.750	2.38e-01	3.14e-01	2.74e-01	4.83e-01	-1.71e-01	-0.265000	3.58e-01	2.25e-01	2.89e-01	6.14e-02	5.07e-01	3.06e-01
Norepinephrine Neurotransmitter Release Cycle	12	2.12e-02	4.21e-02	0.749	3.85e-01	2.15e-01	1.10e-01	3.94e-01	3.68e-01	-0.252000	2.09e-02	1.97e-01	5.09e-01	1.82e-02	2.72e-02	1.30e-01
Pentose phosphate pathway	13	6.09e-03	1.47e-02	0.749	-3.95e-01	-4.80e-01	1.55e-01	-6.13e-03	-2.48e-01	0.299000	1.38e-02	2.75e-03	3.34e-01	9.69e-01	1.21e-01	6.19e-02
Removal of the Flap Intermediate from the C-strand	17	4.91e-05	2.08e-04	0.748	-6.93e-03	-3.85e-01	-1.89e-01	5.27e-01	2.45e-01	0.197000	9.61e-01	6.00e-03	1.78e-01	1.69e-04	8.05e-02	1.61e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	5.16e-03	1.28e-02	0.747	2.00e-01	3.02e-01	5.81e-01	-1.84e-01	-1.33e-01	0.193000	1.79e-01	4.29e-02	9.77e-05	2.17e-01	3.72e-01	1.96e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	1.35e-01	1.93e-01	0.746	1.23e-01	-4.46e-01	-3.39e-01	2.39e-01	2.92e-01	-0.293000	6.03e-01	5.84e-02	1.50e-01	3.11e-01	2.16e-01	2.15e-01
Maturation of TCA enzymes and regulation of TCA cycle	20	1.52e-04	5.75e-04	0.745	-2.43e-01	-6.19e-01	-3.35e-01	1.65e-02	-6.80e-03	0.002010	5.95e-02	1.63e-06	9.57e-03	8.98e-01	9.58e-01	9.88e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	2.28e-01	2.96e-01	0.744	-2.47e-01	-4.26e-01	-5.54e-01	-5.58e-02	4.02e-02	-0.023800	2.95e-01	7.10e-02	1.88e-02	8.13e-01	8.64e-01	9.19e-01
PTK6 promotes HIF1A stabilization	6	1.05e-01	1.59e-01	0.744	-4.67e-01	2.58e-01	2.71e-01	-4.33e-01	-7.49e-02	0.051100	4.78e-02	2.74e-01	2.50e-01	6.62e-02	7.51e-01	8.29e-01
Negative regulation of NOTCH4 signaling	44	8.68e-13	1.01e-11	0.743	-2.55e-01	-5.78e-01	5.26e-02	7.25e-03	-1.34e-01	0.364000	3.43e-03	3.15e-11	5.46e-01	9.34e-01	1.24e-01	2.96e-05
Displacement of DNA glycosylase by APEX1	9	4.82e-02	8.39e-02	0.743	1.03e-01	-4.83e-01	-4.49e-01	1.94e-01	1.24e-01	-0.231000	5.91e-01	1.21e-02	1.96e-02	3.15e-01	5.18e-01	2.29e-01
Unwinding of DNA	12	1.93e-03	5.40e-03	0.743	3.74e-01	-2.31e-01	-3.51e-02	5.18e-01	7.53e-02	0.289000	2.48e-02	1.66e-01	8.33e-01	1.88e-03	6.51e-01	8.30e-02
Sodium/Proton exchangers	7	1.59e-01	2.19e-01	0.742	-2.49e-02	3.99e-01	4.68e-01	1.32e-01	2.29e-01	0.320000	9.09e-01	6.78e-02	3.20e-02	5.44e-01	2.94e-01	1.43e-01
RNA Polymerase III Chain Elongation	18	1.47e-03	4.22e-03	0.739	-1.54e-01	-5.62e-01	-3.85e-01	4.05e-02	-2.04e-01	-0.121000	2.57e-01	3.62e-05	4.72e-03	7.66e-01	1.33e-01	3.73e-01
Expression and translocation of olfactory receptors	48	7.26e-12	7.83e-11	0.738	8.49e-02	2.48e-01	4.52e-01	-4.32e-01	-2.75e-01	0.093600	3.09e-01	2.92e-03	5.83e-08	2.24e-07	9.69e-04	2.62e-01
Respiratory electron transport	149	7.11e-40	2.90e-38	0.736	-1.55e-01	-6.31e-01	-3.35e-01	-1.55e-03	-6.94e-02	-0.046000	1.11e-03	1.71e-40	1.57e-12	9.74e-01	1.44e-01	3.32e-01
Defective factor IX causes hemophilia B	6	9.06e-02	1.41e-01	0.736	3.16e-01	-3.11e-01	2.30e-01	-2.64e-01	-4.65e-01	0.080600	1.80e-01	1.88e-01	3.28e-01	2.63e-01	4.87e-02	7.32e-01
Ubiquitin-dependent degradation of Cyclin D	39	6.77e-11	6.56e-10	0.735	-2.37e-01	-5.82e-01	4.53e-02	-2.42e-02	-1.43e-01	0.350000	1.03e-02	3.22e-10	6.25e-01	7.93e-01	1.22e-01	1.57e-04
Cross-presentation of particulate exogenous antigens (phagosomes)	8	3.72e-02	6.83e-02	0.734	-1.48e-01	1.30e-01	3.64e-01	-5.32e-01	1.86e-02	0.290000	4.68e-01	5.25e-01	7.47e-02	9.16e-03	9.27e-01	1.56e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	6.51e-02	1.08e-01	0.732	-2.12e-01	-1.65e-02	-2.42e-01	6.10e-02	-4.73e-01	-0.454000	4.13e-01	9.49e-01	3.49e-01	8.13e-01	6.72e-02	7.88e-02
RUNX1 regulates estrogen receptor mediated transcription	6	4.11e-01	4.76e-01	0.729	2.50e-01	4.36e-01	3.00e-01	1.91e-01	1.25e-01	0.371000	2.90e-01	6.46e-02	2.03e-01	4.17e-01	5.97e-01	1.16e-01
N-glycan trimming and elongation in the cis-Golgi	5	1.79e-01	2.43e-01	0.729	-3.87e-01	-3.68e-01	-1.55e-01	3.08e-01	-8.11e-02	0.347000	1.34e-01	1.54e-01	5.48e-01	2.32e-01	7.53e-01	1.79e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	6.50e-11	6.34e-10	0.728	-2.40e-01	-5.76e-01	3.73e-02	4.01e-03	-1.87e-01	0.324000	7.04e-03	1.05e-10	6.76e-01	9.64e-01	3.56e-02	2.82e-04
GAB1 signalosome	14	1.40e-05	6.51e-05	0.728	-3.25e-01	2.93e-01	5.59e-01	2.87e-02	-9.58e-02	0.125000	3.53e-02	5.79e-02	2.90e-04	8.52e-01	5.35e-01	4.19e-01
FCGR3A-mediated phagocytosis	120	5.80e-37	2.23e-35	0.728	-8.90e-02	-3.15e-01	2.28e-01	2.86e-01	-3.36e-01	0.419000	9.22e-02	2.46e-09	1.65e-05	6.21e-08	2.14e-10	2.02e-15
Leishmania phagocytosis	120	5.80e-37	2.23e-35	0.728	-8.90e-02	-3.15e-01	2.28e-01	2.86e-01	-3.36e-01	0.419000	9.22e-02	2.46e-09	1.65e-05	6.21e-08	2.14e-10	2.02e-15
Parasite infection	120	5.80e-37	2.23e-35	0.728	-8.90e-02	-3.15e-01	2.28e-01	2.86e-01	-3.36e-01	0.419000	9.22e-02	2.46e-09	1.65e-05	6.21e-08	2.14e-10	2.02e-15
Inactivation of CDC42 and RAC1	7	1.73e-01	2.37e-01	0.727	-2.39e-01	-3.24e-01	3.70e-01	-2.15e-01	-4.09e-01	0.129000	2.74e-01	1.37e-01	8.99e-02	3.25e-01	6.11e-02	5.55e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	4.34e-11	4.33e-10	0.726	-2.58e-01	-5.52e-01	5.65e-02	6.81e-03	-1.53e-01	0.360000	3.80e-03	5.91e-10	5.27e-01	9.39e-01	8.61e-02	5.48e-05
PD-1 signaling	28	7.24e-05	2.91e-04	0.725	2.03e-01	7.72e-02	-2.77e-01	3.87e-01	4.99e-01	-0.049700	6.25e-02	4.80e-01	1.13e-02	3.94e-04	4.83e-06	6.49e-01
Netrin mediated repulsion signals	5	2.32e-01	3.01e-01	0.723	3.55e-02	1.70e-01	5.08e-01	8.50e-02	3.07e-01	0.366000	8.91e-01	5.11e-01	4.92e-02	7.42e-01	2.35e-01	1.56e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	5.29e-06	2.67e-05	0.722	1.78e-02	-3.78e-01	-3.70e-01	3.41e-01	3.46e-01	-0.073900	8.78e-01	1.08e-03	1.38e-03	3.15e-03	2.74e-03	5.23e-01
Serotonin Neurotransmitter Release Cycle	13	2.83e-02	5.42e-02	0.722	3.17e-01	2.40e-01	1.77e-01	4.03e-01	4.04e-01	-0.078400	4.80e-02	1.34e-01	2.69e-01	1.19e-02	1.18e-02	6.25e-01
FCERI mediated Ca+2 mobilization	91	1.03e-27	2.45e-26	0.721	3.32e-02	-3.08e-01	2.18e-01	3.19e-01	-3.19e-01	0.416000	5.84e-01	3.75e-07	3.25e-04	1.48e-07	1.47e-07	6.74e-12
Folding of actin by CCT/TriC	10	2.91e-02	5.55e-02	0.721	-2.67e-01	-5.95e-01	-8.44e-02	1.12e-01	-1.41e-01	0.234000	1.44e-01	1.12e-03	6.44e-01	5.39e-01	4.41e-01	2.00e-01
OAS antiviral response	8	2.49e-02	4.86e-02	0.720	-1.81e-01	-9.17e-02	-9.63e-02	2.60e-01	3.28e-01	0.541000	3.76e-01	6.53e-01	6.37e-01	2.02e-01	1.09e-01	8.03e-03
Metabolism of polyamines	46	2.74e-11	2.80e-10	0.720	-2.86e-01	-5.54e-01	4.02e-02	-4.50e-02	-1.73e-01	0.309000	7.95e-04	7.54e-11	6.37e-01	5.97e-01	4.25e-02	2.86e-04
Adenylate cyclase activating pathway	8	4.45e-02	7.85e-02	0.719	1.69e-01	5.14e-01	2.19e-01	2.86e-01	1.52e-01	-0.267000	4.08e-01	1.18e-02	2.82e-01	1.61e-01	4.56e-01	1.90e-01
Regulation of IFNG signaling	14	2.00e-02	4.01e-02	0.719	-2.19e-01	1.25e-01	3.84e-01	-1.43e-01	-2.06e-01	0.492000	1.56e-01	4.16e-01	1.29e-02	3.55e-01	1.82e-01	1.42e-03
Proteasome assembly	50	3.80e-14	5.03e-13	0.718	-2.25e-01	-5.95e-01	-7.47e-02	3.05e-02	-8.43e-02	0.312000	5.89e-03	3.38e-13	3.61e-01	7.09e-01	3.02e-01	1.34e-04
Signaling by FLT3 fusion proteins	18	4.28e-04	1.42e-03	0.717	-8.62e-02	4.00e-01	3.89e-01	2.41e-01	1.92e-01	0.318000	5.26e-01	3.27e-03	4.31e-03	7.68e-02	1.58e-01	1.96e-02
Purine ribonucleoside monophosphate biosynthesis	9	9.44e-02	1.46e-01	0.717	-1.75e-01	-5.03e-01	-4.12e-01	2.03e-01	8.12e-02	-0.110000	3.63e-01	8.92e-03	3.22e-02	2.91e-01	6.73e-01	5.68e-01
Processive synthesis on the C-strand of the telomere	19	4.88e-05	2.08e-04	0.717	6.97e-02	-3.61e-01	-1.78e-01	5.31e-01	2.14e-01	0.138000	5.99e-01	6.43e-03	1.78e-01	6.15e-05	1.06e-01	2.98e-01
Role of phospholipids in phagocytosis	87	3.95e-28	9.97e-27	0.717	4.30e-02	-3.26e-01	1.73e-01	3.73e-01	-3.20e-01	0.367000	4.88e-01	1.46e-07	5.26e-03	1.87e-09	2.56e-07	3.18e-09
Prostanoid ligand receptors	8	1.36e-01	1.95e-01	0.717	-3.35e-01	-2.91e-01	3.53e-01	-2.11e-01	-3.15e-01	0.221000	1.00e-01	1.54e-01	8.39e-02	3.02e-01	1.23e-01	2.80e-01
Axonal growth inhibition (RHOA activation)	7	5.96e-02	1.01e-01	0.715	-2.85e-01	-3.07e-01	4.59e-01	-1.86e-01	-2.32e-01	0.190000	1.92e-01	1.60e-01	3.53e-02	3.93e-01	2.87e-01	3.84e-01
p75NTR regulates axonogenesis	7	5.96e-02	1.01e-01	0.715	-2.85e-01	-3.07e-01	4.59e-01	-1.86e-01	-2.32e-01	0.190000	1.92e-01	1.60e-01	3.53e-02	3.93e-01	2.87e-01	3.84e-01
SARS-CoV-2 modulates autophagy	11	4.71e-03	1.18e-02	0.715	-3.54e-01	-2.67e-01	-2.77e-01	3.57e-01	2.64e-01	-0.200000	4.22e-02	1.25e-01	1.11e-01	4.02e-02	1.29e-01	2.51e-01
Prolonged ERK activation events	13	1.41e-02	3.02e-02	0.715	-3.78e-01	-4.35e-02	3.18e-01	-7.48e-02	-3.55e-01	0.365000	1.83e-02	7.86e-01	4.68e-02	6.41e-01	2.67e-02	2.28e-02
Bicarbonate transporters	9	2.59e-02	5.02e-02	0.714	8.22e-02	4.84e-01	-2.79e-02	4.31e-01	2.42e-01	0.157000	6.69e-01	1.20e-02	8.85e-01	2.51e-02	2.08e-01	4.16e-01
Olfactory Signaling Pathway	53	7.30e-12	7.83e-11	0.714	5.89e-02	2.36e-01	4.57e-01	-3.82e-01	-2.96e-01	0.089900	4.58e-01	2.96e-03	8.39e-09	1.48e-06	1.90e-04	2.57e-01
Malate-aspartate shuttle	8	6.69e-02	1.10e-01	0.714	-8.53e-03	-5.20e-01	-3.71e-01	2.71e-01	1.68e-01	-0.005370	9.67e-01	1.08e-02	6.91e-02	1.84e-01	4.12e-01	9.79e-01
Activation of PUMA and translocation to mitochondria	8	4.54e-02	7.97e-02	0.714	2.23e-01	2.74e-01	-1.79e-02	6.02e-01	7.79e-02	-0.128000	2.76e-01	1.80e-01	9.30e-01	3.19e-03	7.03e-01	5.29e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	1.34e-02	2.89e-02	0.712	3.89e-01	2.77e-01	2.48e-01	-1.32e-01	-4.23e-01	0.147000	4.34e-02	1.50e-01	1.97e-01	4.92e-01	2.81e-02	4.44e-01
Cross-presentation of soluble exogenous antigens (endosomes)	35	4.18e-09	3.39e-08	0.712	-2.23e-01	-5.25e-01	1.23e-01	1.05e-02	-1.45e-01	0.381000	2.23e-02	7.39e-08	2.06e-01	9.14e-01	1.38e-01	9.64e-05
Citric acid cycle (TCA cycle)	34	1.79e-07	1.13e-06	0.711	-3.01e-01	-5.91e-01	-2.44e-01	1.48e-02	-3.29e-02	0.067200	2.35e-03	2.36e-09	1.37e-02	8.81e-01	7.40e-01	4.98e-01
PCNA-Dependent Long Patch Base Excision Repair	21	5.22e-05	2.20e-04	0.711	-1.65e-02	-4.21e-01	-3.77e-01	2.68e-01	3.29e-01	-0.076900	8.96e-01	8.38e-04	2.81e-03	3.37e-02	8.96e-03	5.42e-01
Mitochondrial protein degradation	96	1.30e-20	2.40e-19	0.709	-2.38e-01	-5.75e-01	-3.20e-01	2.88e-02	-1.11e-01	-0.018200	5.44e-05	1.90e-22	6.25e-08	6.26e-01	6.00e-02	7.58e-01
Platelet Adhesion to exposed collagen	14	5.48e-03	1.35e-02	0.709	2.23e-01	-2.31e-01	3.78e-01	-9.59e-02	-4.09e-01	0.282000	1.49e-01	1.35e-01	1.42e-02	5.34e-01	7.98e-03	6.76e-02
Regulation of Complement cascade	95	8.23e-29	2.19e-27	0.709	2.69e-02	-4.19e-01	1.90e-01	2.67e-01	-3.95e-01	0.251000	6.51e-01	1.69e-12	1.37e-03	6.93e-06	2.73e-11	2.40e-05
RUNX3 regulates CDKN1A transcription	7	2.17e-01	2.83e-01	0.708	1.09e-01	1.01e-01	-3.80e-01	9.52e-02	6.42e-02	-0.568000	6.19e-01	6.45e-01	8.15e-02	6.63e-01	7.69e-01	9.31e-03
Signaling by LTK in cancer	7	9.41e-02	1.45e-01	0.707	-3.21e-01	2.29e-01	4.21e-01	8.42e-02	-8.52e-02	0.391000	1.41e-01	2.94e-01	5.40e-02	7.00e-01	6.96e-01	7.30e-02
Coenzyme A biosynthesis	7	7.62e-02	1.23e-01	0.707	-1.87e-01	-2.15e-01	-1.86e-01	3.67e-01	4.95e-01	0.071900	3.92e-01	3.26e-01	3.94e-01	9.30e-02	2.34e-02	7.42e-01
Transport of nucleotide sugars	9	2.39e-01	3.08e-01	0.705	-4.41e-01	-3.15e-01	-2.74e-01	-2.58e-01	-8.38e-02	-0.233000	2.18e-02	1.02e-01	1.54e-01	1.80e-01	6.63e-01	2.26e-01
Inhibition of DNA recombination at telomere	33	1.29e-07	8.35e-07	0.704	-1.79e-01	-5.85e-01	-6.29e-02	1.07e-01	-2.65e-01	0.186000	7.43e-02	5.80e-09	5.32e-01	2.86e-01	8.36e-03	6.51e-02
Frs2-mediated activation	11	4.89e-02	8.48e-02	0.703	-3.86e-01	-1.07e-01	2.95e-01	-7.80e-02	-3.55e-01	0.339000	2.66e-02	5.37e-01	9.03e-02	6.54e-01	4.13e-02	5.19e-02
Diseases of Mismatch Repair (MMR)	5	2.71e-01	3.41e-01	0.701	-2.53e-01	-3.13e-01	4.48e-03	1.29e-01	-7.75e-02	0.554000	3.26e-01	2.26e-01	9.86e-01	6.17e-01	7.64e-01	3.19e-02
Degradation of GLI2 by the proteasome	45	7.71e-11	7.33e-10	0.701	-2.64e-01	-5.04e-01	8.00e-02	3.15e-02	-1.58e-01	0.367000	2.14e-03	4.76e-09	3.53e-01	7.15e-01	6.69e-02	2.00e-05
GLI3 is processed to GLI3R by the proteasome	45	7.71e-11	7.33e-10	0.701	-2.64e-01	-5.04e-01	8.00e-02	3.15e-02	-1.58e-01	0.367000	2.14e-03	4.76e-09	3.53e-01	7.15e-01	6.69e-02	2.00e-05
G0 and Early G1	27	3.89e-06	2.01e-05	0.701	8.31e-02	-1.52e-01	3.13e-01	3.94e-01	-4.38e-02	0.454000	4.55e-01	1.72e-01	4.87e-03	3.90e-04	6.94e-01	4.42e-05
Autodegradation of the E3 ubiquitin ligase COP1	38	1.04e-09	9.06e-09	0.701	-2.13e-01	-5.57e-01	2.76e-02	7.34e-03	-1.28e-01	0.344000	2.29e-02	2.85e-09	7.69e-01	9.38e-01	1.71e-01	2.44e-04
Regulation of Expression and Function of Type II Classical Cadherins	23	1.85e-04	6.75e-04	0.700	5.87e-02	5.24e-01	2.34e-01	2.07e-01	3.31e-01	0.073200	6.26e-01	1.35e-05	5.18e-02	8.59e-02	6.01e-03	5.43e-01
Regulation of Homotypic Cell-Cell Adhesion	23	1.85e-04	6.75e-04	0.700	5.87e-02	5.24e-01	2.34e-01	2.07e-01	3.31e-01	0.073200	6.26e-01	1.35e-05	5.18e-02	8.59e-02	6.01e-03	5.43e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	2.14e-03	5.94e-03	0.700	-2.56e-01	2.05e-01	5.55e-01	2.53e-01	-3.54e-02	0.094000	2.10e-01	3.16e-01	6.54e-03	2.14e-01	8.62e-01	6.45e-01
Resolution of Abasic Sites (AP sites)	38	2.54e-08	1.86e-07	0.699	6.76e-02	-3.51e-01	-3.74e-01	3.33e-01	3.02e-01	-0.133000	4.71e-01	1.77e-04	6.48e-05	3.79e-04	1.28e-03	1.55e-01
SCF-beta-TrCP mediated degradation of Emi1	42	4.95e-11	4.90e-10	0.698	-2.01e-01	-5.56e-01	5.06e-02	4.58e-02	-1.27e-01	0.343000	2.42e-02	4.58e-10	5.70e-01	6.07e-01	1.53e-01	1.19e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	63	1.14e-15	1.72e-14	0.698	-1.90e-01	-5.45e-01	3.95e-02	-2.63e-02	-1.94e-01	0.339000	9.10e-03	7.39e-14	5.88e-01	7.18e-01	7.65e-03	3.24e-06
Interleukin-15 signaling	14	1.78e-02	3.63e-02	0.698	6.16e-02	4.37e-01	2.69e-01	3.06e-01	1.95e-01	0.298000	6.90e-01	4.65e-03	8.09e-02	4.78e-02	2.06e-01	5.39e-02
Interleukin receptor SHC signaling	23	6.98e-04	2.18e-03	0.697	1.16e-01	4.26e-01	3.09e-01	2.82e-01	1.31e-01	0.314000	3.35e-01	4.04e-04	1.02e-02	1.90e-02	2.78e-01	9.10e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	8.40e-04	2.57e-03	0.697	1.51e-02	-4.21e-01	-1.64e-01	3.99e-01	2.77e-01	0.211000	9.22e-01	6.36e-03	2.87e-01	9.66e-03	7.28e-02	1.72e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	9.11e-15	1.25e-13	0.696	-2.04e-01	-5.58e-01	9.93e-03	-2.37e-02	-1.81e-01	0.314000	6.32e-03	7.27e-14	8.94e-01	7.51e-01	1.53e-02	2.61e-05
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	1.62e-02	3.39e-02	0.696	1.55e-01	-3.25e-01	2.42e-01	-1.92e-01	-4.88e-01	0.146000	3.52e-01	5.13e-02	1.46e-01	2.49e-01	3.44e-03	3.83e-01
SCF(Skp2)-mediated degradation of p27/p21	50	4.22e-14	5.54e-13	0.694	-1.96e-01	-5.61e-01	1.02e-01	8.40e-03	-1.11e-01	0.327000	1.67e-02	6.74e-12	2.12e-01	9.18e-01	1.74e-01	6.42e-05
Biosynthesis of EPA-derived SPMs	6	8.59e-02	1.35e-01	0.694	3.38e-02	2.20e-01	3.45e-01	-5.59e-01	2.13e-02	-0.026800	8.86e-01	3.51e-01	1.44e-01	1.77e-02	9.28e-01	9.09e-01
Regulation of actin dynamics for phagocytic cup formation	122	5.49e-34	1.78e-32	0.694	-6.39e-02	-2.96e-01	2.37e-01	2.90e-01	-3.00e-01	0.399000	2.23e-01	1.59e-08	5.97e-06	3.09e-08	1.05e-08	2.50e-14
RHO GTPases activate PKNs	46	4.14e-08	2.88e-07	0.694	-1.75e-01	-3.87e-01	2.04e-01	-9.53e-02	-4.21e-01	0.270000	4.04e-02	5.62e-06	1.67e-02	2.63e-01	7.55e-07	1.52e-03
RUNX3 regulates WNT signaling	8	3.07e-01	3.76e-01	0.693	3.37e-01	2.13e-01	4.62e-01	1.43e-01	5.88e-02	0.290000	9.86e-02	2.97e-01	2.36e-02	4.83e-01	7.73e-01	1.55e-01
Advanced glycosylation endproduct receptor signaling	12	7.55e-02	1.22e-01	0.692	-4.80e-01	-3.22e-01	-6.68e-03	-1.40e-01	-2.92e-01	0.200000	3.95e-03	5.36e-02	9.68e-01	4.01e-01	7.95e-02	2.31e-01
DNA replication initiation	8	2.30e-01	2.99e-01	0.692	-1.67e-01	-4.30e-01	-4.17e-01	1.78e-01	6.09e-02	-0.238000	4.14e-01	3.53e-02	4.10e-02	3.82e-01	7.65e-01	2.44e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	8.25e-16	1.25e-14	0.689	-1.75e-01	-5.37e-01	4.82e-02	-1.08e-02	-1.87e-01	0.343000	1.52e-02	1.04e-13	5.05e-01	8.81e-01	9.87e-03	2.06e-06
Beta-oxidation of pristanoyl-CoA	9	7.70e-02	1.24e-01	0.688	-5.42e-01	-2.91e-01	-8.43e-02	-1.35e-01	7.07e-02	0.252000	4.84e-03	1.30e-01	6.61e-01	4.82e-01	7.13e-01	1.91e-01
Alternative complement activation	5	3.69e-01	4.34e-01	0.687	1.64e-02	-3.43e-01	-3.59e-01	2.78e-01	3.81e-01	-0.056000	9.49e-01	1.84e-01	1.64e-01	2.81e-01	1.40e-01	8.28e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	4.53e-01	5.16e-01	0.687	2.61e-01	3.06e-01	1.56e-02	2.98e-01	2.54e-01	-0.394000	3.12e-01	2.36e-01	9.52e-01	2.48e-01	3.25e-01	1.27e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	1.59e-08	1.20e-07	0.686	-4.65e-01	-2.52e-01	-5.18e-03	2.15e-01	-2.03e-01	0.321000	1.46e-05	1.89e-02	9.62e-01	4.46e-02	5.81e-02	2.73e-03
Incretin synthesis, secretion, and inactivation	14	2.71e-02	5.22e-02	0.686	-4.33e-01	-3.37e-01	8.91e-02	-2.47e-01	-1.40e-01	0.284000	4.99e-03	2.89e-02	5.64e-01	1.10e-01	3.64e-01	6.54e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	2.71e-02	5.22e-02	0.686	-4.33e-01	-3.37e-01	8.91e-02	-2.47e-01	-1.40e-01	0.284000	4.99e-03	2.89e-02	5.64e-01	1.10e-01	3.64e-01	6.54e-02
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	6.10e-03	1.47e-02	0.686	-2.90e-01	-3.66e-01	7.46e-02	3.60e-02	-3.08e-01	0.387000	4.47e-02	1.12e-02	6.06e-01	8.03e-01	3.28e-02	7.28e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	2.36e-14	3.18e-13	0.685	-1.96e-01	-5.40e-01	2.36e-02	-2.55e-02	-1.90e-01	0.320000	8.17e-03	3.01e-13	7.50e-01	7.30e-01	1.01e-02	1.52e-05
Regulation of CDH11 Expression and Function	22	4.57e-04	1.51e-03	0.685	3.35e-02	5.05e-01	2.05e-01	2.22e-01	3.28e-01	0.117000	7.85e-01	4.07e-05	9.57e-02	7.14e-02	7.79e-03	3.43e-01
Passive transport by Aquaporins	6	3.39e-01	4.05e-01	0.685	-1.58e-01	1.51e-02	-2.07e-02	-5.09e-01	-4.15e-01	-0.107000	5.04e-01	9.49e-01	9.30e-01	3.08e-02	7.80e-02	6.49e-01
FCGR3A-mediated IL10 synthesis	98	1.98e-27	4.51e-26	0.683	3.12e-02	-2.53e-01	2.11e-01	3.38e-01	-2.94e-01	0.396000	5.94e-01	1.48e-05	3.06e-04	7.37e-09	5.07e-07	1.19e-11
Activation of the AP-1 family of transcription factors	10	1.09e-01	1.64e-01	0.683	-4.07e-01	3.60e-02	2.57e-01	-3.95e-01	-2.17e-01	0.175000	2.58e-02	8.44e-01	1.60e-01	3.06e-02	2.34e-01	3.37e-01
PTK6 Regulates Cell Cycle	6	1.88e-02	3.81e-02	0.682	-2.27e-01	-3.31e-01	1.14e-01	3.92e-01	3.67e-01	0.056500	3.35e-01	1.60e-01	6.30e-01	9.65e-02	1.20e-01	8.11e-01
Activation of NOXA and translocation to mitochondria	5	4.63e-01	5.23e-01	0.682	1.61e-01	2.58e-01	-1.83e-01	4.35e-01	3.66e-01	0.131000	5.34e-01	3.17e-01	4.77e-01	9.24e-02	1.57e-01	6.12e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	14	3.97e-02	7.23e-02	0.682	1.43e-01	2.86e-01	-2.13e-01	1.09e-01	4.91e-01	-0.255000	3.53e-01	6.42e-02	1.68e-01	4.78e-01	1.48e-03	9.85e-02
Synthesis of glycosylphosphatidylinositol (GPI)	18	1.88e-02	3.81e-02	0.682	-2.96e-01	-3.27e-01	-4.22e-01	-9.68e-02	9.61e-02	-0.272000	2.99e-02	1.64e-02	1.93e-03	4.77e-01	4.80e-01	4.56e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	59	5.64e-15	7.85e-14	0.682	-1.19e-01	-5.14e-01	1.80e-01	2.34e-02	-2.14e-01	0.327000	1.13e-01	8.06e-12	1.70e-02	7.55e-01	4.45e-03	1.35e-05
STAT5 activation downstream of FLT3 ITD mutants	9	1.23e-02	2.69e-02	0.681	-1.23e-01	1.08e-01	5.94e-01	1.54e-01	-1.92e-01	0.153000	5.21e-01	5.76e-01	2.04e-03	4.24e-01	3.20e-01	4.27e-01
Mitochondrial iron-sulfur cluster biogenesis	13	1.09e-03	3.23e-03	0.680	6.78e-02	-5.90e-01	-3.17e-01	-9.88e-05	9.36e-02	-0.032400	6.72e-01	2.30e-04	4.81e-02	1.00e+00	5.59e-01	8.40e-01
Urea cycle	6	2.91e-01	3.60e-01	0.680	-4.76e-02	-5.13e-01	8.41e-02	-2.48e-02	-4.35e-01	-0.021500	8.40e-01	2.96e-02	7.21e-01	9.16e-01	6.53e-02	9.27e-01
Nef and signal transduction	8	4.70e-02	8.23e-02	0.679	3.76e-02	3.37e-01	1.39e-01	4.58e-01	4.05e-02	0.340000	8.54e-01	9.86e-02	4.95e-01	2.49e-02	8.43e-01	9.63e-02
Presynaptic depolarization and calcium channel opening	8	1.46e-01	2.06e-01	0.678	8.74e-02	3.83e-01	-2.47e-01	-1.31e-01	3.17e-01	-0.356000	6.68e-01	6.08e-02	2.26e-01	5.22e-01	1.20e-01	8.15e-02
Mitophagy	38	1.01e-06	5.74e-06	0.678	-2.36e-01	-4.91e-01	-2.09e-01	-1.11e-01	-2.96e-01	0.138000	1.20e-02	1.60e-07	2.61e-02	2.36e-01	1.59e-03	1.41e-01
APC/C:Cdc20 mediated degradation of Securin	55	1.56e-12	1.77e-11	0.677	-2.23e-01	-5.58e-01	-3.79e-02	-5.65e-02	-1.47e-01	0.267000	4.21e-03	8.22e-13	6.27e-01	4.69e-01	5.95e-02	6.16e-04
Defective GALNT12 causes CRCS1	8	2.53e-01	3.22e-01	0.676	2.13e-01	4.44e-01	4.47e-01	-7.30e-02	1.91e-02	0.101000	2.98e-01	2.97e-02	2.87e-02	7.21e-01	9.26e-01	6.22e-01
FCERI mediated NF-kB activation	128	1.05e-31	3.20e-30	0.676	-8.74e-02	-4.07e-01	1.57e-01	1.68e-01	-3.01e-01	0.374000	8.78e-02	1.72e-15	2.09e-03	1.05e-03	3.81e-09	2.66e-13
Protein methylation	15	3.19e-02	6.01e-02	0.675	-2.03e-01	-5.15e-01	-3.53e-01	-7.59e-02	-1.00e-01	-0.098300	1.72e-01	5.56e-04	1.81e-02	6.11e-01	5.01e-01	5.10e-01
Regulation of MECP2 expression and activity	28	7.81e-06	3.79e-05	0.675	-2.92e-02	3.40e-01	1.35e-01	4.00e-01	2.89e-01	0.277000	7.89e-01	1.82e-03	2.15e-01	2.52e-04	8.05e-03	1.11e-02
Apoptotic cleavage of cell adhesion proteins	8	2.64e-01	3.33e-01	0.675	-4.81e-01	-9.40e-02	1.31e-01	-2.69e-01	-2.20e-01	0.277000	1.85e-02	6.45e-01	5.21e-01	1.87e-01	2.81e-01	1.74e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	5.84e-02	9.91e-02	0.674	-3.15e-01	-5.24e-03	1.64e-01	1.23e-01	8.11e-02	0.553000	1.02e-01	9.78e-01	3.93e-01	5.23e-01	6.74e-01	4.05e-03
Negative feedback regulation of MAPK pathway	6	3.31e-01	3.98e-01	0.673	-4.74e-01	-2.65e-01	1.01e-01	-1.63e-01	-3.46e-01	-0.039300	4.42e-02	2.61e-01	6.69e-01	4.89e-01	1.42e-01	8.68e-01
CREB phosphorylation	7	6.16e-02	1.03e-01	0.673	-4.22e-01	2.03e-01	1.18e-01	5.91e-02	-2.77e-02	0.465000	5.33e-02	3.53e-01	5.88e-01	7.86e-01	8.99e-01	3.31e-02
Cleavage of the damaged pyrimidine	26	2.86e-05	1.26e-04	0.672	-1.32e-01	-5.67e-01	-1.20e-02	5.11e-02	-2.81e-01	0.176000	2.46e-01	5.56e-07	9.16e-01	6.52e-01	1.31e-02	1.20e-01
Depyrimidination	26	2.86e-05	1.26e-04	0.672	-1.32e-01	-5.67e-01	-1.20e-02	5.11e-02	-2.81e-01	0.176000	2.46e-01	5.56e-07	9.16e-01	6.52e-01	1.31e-02	1.20e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	26	2.86e-05	1.26e-04	0.672	-1.32e-01	-5.67e-01	-1.20e-02	5.11e-02	-2.81e-01	0.176000	2.46e-01	5.56e-07	9.16e-01	6.52e-01	1.31e-02	1.20e-01
Phosphorylation of CD3 and TCR zeta chains	27	2.35e-04	8.35e-04	0.672	1.31e-01	7.70e-02	-2.76e-01	3.28e-01	4.94e-01	0.007930	2.37e-01	4.89e-01	1.31e-02	3.13e-03	8.92e-06	9.43e-01
FCERI mediated MAPK activation	92	1.82e-23	3.64e-22	0.671	-1.99e-02	-3.21e-01	2.06e-01	2.64e-01	-3.14e-01	0.370000	7.41e-01	9.86e-08	6.54e-04	1.20e-05	1.99e-07	8.84e-10
NR1H2 and NR1H3-mediated signaling	38	2.65e-12	2.96e-11	0.671	-9.75e-02	2.20e-01	1.66e-01	5.14e-01	3.17e-01	0.006090	2.98e-01	1.89e-02	7.60e-02	4.12e-08	7.25e-04	9.48e-01
TGFBR3 regulates TGF-beta signaling	8	3.92e-02	7.16e-02	0.671	-2.21e-01	1.47e-01	-2.26e-01	4.81e-01	3.04e-01	0.070000	2.78e-01	4.71e-01	2.68e-01	1.85e-02	1.36e-01	7.32e-01
RNA Polymerase I Promoter Escape	45	2.06e-07	1.30e-06	0.670	-2.35e-01	-5.48e-01	-1.12e-01	-1.02e-01	-2.63e-01	0.015700	6.30e-03	1.94e-10	1.92e-01	2.39e-01	2.23e-03	8.56e-01
Formation of apoptosome	11	5.14e-02	8.85e-02	0.669	-4.87e-01	-2.59e-01	-1.72e-01	-1.31e-01	-5.63e-02	0.305000	5.15e-03	1.36e-01	3.24e-01	4.53e-01	7.47e-01	7.96e-02
Regulation of the apoptosome activity	11	5.14e-02	8.85e-02	0.669	-4.87e-01	-2.59e-01	-1.72e-01	-1.31e-01	-5.63e-02	0.305000	5.15e-03	1.36e-01	3.24e-01	4.53e-01	7.47e-01	7.96e-02
Synthesis of Dolichyl-phosphate	6	7.74e-02	1.24e-01	0.669	-1.28e-01	-5.26e-01	2.14e-01	2.76e-01	-1.07e-01	0.146000	5.86e-01	2.57e-02	3.65e-01	2.42e-01	6.49e-01	5.36e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	2.05e-01	2.72e-01	0.668	-3.50e-01	-4.43e-01	-1.92e-01	-8.21e-02	-2.50e-01	-0.149000	5.54e-02	1.52e-02	2.94e-01	6.53e-01	1.72e-01	4.15e-01
Digestion	5	4.46e-01	5.08e-01	0.667	2.09e-01	-8.53e-03	4.18e-01	-1.16e-02	-4.68e-01	0.086300	4.17e-01	9.74e-01	1.06e-01	9.64e-01	7.00e-02	7.38e-01
Gain-of-function MRAS complexes activate RAF signaling	8	8.00e-02	1.27e-01	0.664	-4.56e-01	9.44e-02	2.76e-01	-1.38e-01	8.69e-02	0.348000	2.55e-02	6.44e-01	1.76e-01	5.00e-01	6.70e-01	8.81e-02
SHOC2 M1731 mutant abolishes MRAS complex function	8	8.00e-02	1.27e-01	0.664	-4.56e-01	9.44e-02	2.76e-01	-1.38e-01	8.69e-02	0.348000	2.55e-02	6.44e-01	1.76e-01	5.00e-01	6.70e-01	8.81e-02
Signaling by MRAS-complex mutants	8	8.00e-02	1.27e-01	0.664	-4.56e-01	9.44e-02	2.76e-01	-1.38e-01	8.69e-02	0.348000	2.55e-02	6.44e-01	1.76e-01	5.00e-01	6.70e-01	8.81e-02
TP53 Regulates Transcription of Death Receptors and Ligands	11	2.90e-02	5.53e-02	0.664	1.57e-01	4.21e-01	2.42e-02	1.90e-01	1.95e-01	-0.405000	3.66e-01	1.57e-02	8.90e-01	2.76e-01	2.63e-01	2.00e-02
ABC transporter disorders	59	3.80e-12	4.17e-11	0.664	-2.61e-01	-4.53e-01	1.31e-01	6.46e-04	-1.98e-01	0.333000	5.27e-04	1.69e-09	8.16e-02	9.93e-01	8.69e-03	9.88e-06
MAPK3 (ERK1) activation	9	1.26e-02	2.73e-02	0.662	-4.38e-01	3.98e-02	2.42e-01	2.11e-01	-1.73e-01	0.335000	2.29e-02	8.36e-01	2.09e-01	2.73e-01	3.68e-01	8.21e-02
Keratan sulfate degradation	9	2.63e-01	3.32e-01	0.661	-1.84e-01	-1.86e-01	-1.73e-02	-4.29e-01	-3.78e-01	-0.204000	3.40e-01	3.33e-01	9.28e-01	2.58e-02	4.95e-02	2.89e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	3.64e-02	6.70e-02	0.661	6.67e-02	-2.63e-01	4.01e-01	-1.45e-01	-3.83e-01	0.187000	6.89e-01	1.14e-01	1.61e-02	3.84e-01	2.15e-02	2.63e-01
Transport of connexons to the plasma membrane	12	3.64e-02	6.70e-02	0.661	6.67e-02	-2.63e-01	4.01e-01	-1.45e-01	-3.83e-01	0.187000	6.89e-01	1.14e-01	1.61e-02	3.84e-01	2.15e-02	2.63e-01
Glycosphingolipid transport	7	6.76e-02	1.11e-01	0.661	-4.03e-01	-1.28e-01	-1.87e-01	3.40e-01	3.21e-01	-0.068400	6.51e-02	5.56e-01	3.91e-01	1.19e-01	1.41e-01	7.54e-01
RHO GTPases Activate WASPs and WAVEs	35	3.33e-07	2.00e-06	0.660	-3.47e-01	-1.69e-01	2.74e-01	8.20e-02	-1.96e-01	0.409000	3.84e-04	8.30e-02	5.07e-03	4.01e-01	4.49e-02	2.81e-05
Degradation of GLI1 by the proteasome	46	1.55e-09	1.33e-08	0.660	-2.46e-01	-4.69e-01	8.22e-02	4.16e-02	-1.71e-01	0.343000	3.94e-03	3.65e-08	3.35e-01	6.26e-01	4.45e-02	5.71e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	2.94e-11	2.98e-10	0.660	-2.16e-01	-4.83e-01	8.02e-02	-2.38e-02	-1.50e-01	0.355000	7.08e-03	1.67e-09	3.17e-01	7.67e-01	6.17e-02	9.45e-06
Lagging Strand Synthesis	20	4.02e-04	1.34e-03	0.660	7.63e-02	-3.74e-01	-3.49e-01	2.69e-01	3.02e-01	-0.063500	5.55e-01	3.79e-03	6.97e-03	3.72e-02	1.92e-02	6.23e-01
Lipophagy	7	2.66e-01	3.35e-01	0.660	-3.44e-01	-3.59e-01	-5.41e-02	2.84e-02	-3.88e-01	0.181000	1.15e-01	9.96e-02	8.04e-01	8.96e-01	7.52e-02	4.07e-01
Platelet degranulation	104	3.45e-18	5.87e-17	0.659	-2.72e-01	-3.78e-01	2.05e-01	-1.19e-01	-3.19e-01	0.244000	1.62e-06	2.55e-11	3.10e-04	3.56e-02	1.96e-08	1.71e-05
Nucleotide biosynthesis	12	3.88e-02	7.10e-02	0.658	-9.71e-02	-3.48e-01	-3.31e-01	3.54e-01	2.32e-01	-0.112000	5.60e-01	3.67e-02	4.68e-02	3.37e-02	1.64e-01	5.01e-01
GRB2 events in EGFR signaling	10	3.29e-03	8.67e-03	0.657	-2.56e-01	2.30e-01	5.43e-01	-1.09e-01	1.83e-02	0.077500	1.61e-01	2.07e-01	2.93e-03	5.50e-01	9.20e-01	6.71e-01
Regulation of HMOX1 expression and activity	5	2.05e-02	4.10e-02	0.657	-1.58e-01	2.39e-01	3.50e-01	3.76e-01	8.82e-02	-0.279000	5.42e-01	3.54e-01	1.75e-01	1.45e-01	7.33e-01	2.81e-01
EGFR Transactivation by Gastrin	7	1.69e-01	2.32e-01	0.657	-9.55e-02	1.42e-01	4.91e-01	-1.28e-01	1.30e-01	0.358000	6.62e-01	5.15e-01	2.45e-02	5.57e-01	5.51e-01	1.01e-01
Phase 4 - resting membrane potential	9	1.42e-01	2.02e-01	0.657	-4.87e-02	2.86e-01	4.01e-01	2.12e-01	1.80e-01	0.330000	8.00e-01	1.37e-01	3.72e-02	2.71e-01	3.49e-01	8.65e-02
G1/S-Specific Transcription	29	2.58e-06	1.38e-05	0.656	8.20e-02	-2.41e-01	2.06e-01	3.61e-01	-4.15e-02	0.437000	4.44e-01	2.45e-02	5.47e-02	7.75e-04	6.99e-01	4.56e-05
Complement cascade	99	5.47e-26	1.18e-24	0.656	1.79e-02	-4.05e-01	1.50e-01	2.63e-01	-3.51e-01	0.226000	7.59e-01	3.31e-12	9.74e-03	6.09e-06	1.51e-09	1.05e-04
Release of apoptotic factors from the mitochondria	6	2.15e-01	2.82e-01	0.656	-3.22e-02	-5.60e-01	-2.18e-01	2.41e-01	6.44e-02	0.075600	8.91e-01	1.76e-02	3.55e-01	3.07e-01	7.85e-01	7.48e-01
Ca2+ activated K+ channels	6	1.28e-01	1.86e-01	0.656	2.20e-01	-2.43e-01	-8.29e-03	-1.36e-01	-1.74e-01	-0.523000	3.50e-01	3.02e-01	9.72e-01	5.63e-01	4.59e-01	2.67e-02
Regulation of CDH11 gene transcription	5	2.65e-01	3.34e-01	0.655	-4.95e-02	3.87e-01	1.14e-01	9.93e-02	4.55e-01	-0.218000	8.48e-01	1.34e-01	6.59e-01	7.01e-01	7.83e-02	3.99e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	9.48e-05	3.74e-04	0.655	-3.74e-03	-4.95e-01	-2.67e-01	3.20e-01	-4.45e-02	-0.094600	9.75e-01	4.03e-05	2.68e-02	7.92e-03	7.12e-01	4.32e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	2.43e-02	4.75e-02	0.655	-6.53e-02	-4.45e-01	-4.53e-01	1.19e-02	1.17e-01	-0.087900	6.83e-01	5.49e-03	4.72e-03	9.41e-01	4.64e-01	5.83e-01
MAPK1 (ERK2) activation	8	3.56e-02	6.57e-02	0.654	-4.00e-01	1.04e-01	2.23e-01	2.06e-01	-1.20e-01	0.388000	5.03e-02	6.10e-01	2.75e-01	3.13e-01	5.56e-01	5.71e-02
Glycogen synthesis	11	8.90e-02	1.39e-01	0.654	-3.25e-01	-3.44e-01	-3.50e-02	-4.15e-02	-3.30e-01	0.303000	6.18e-02	4.82e-02	8.41e-01	8.12e-01	5.84e-02	8.20e-02
Complex IV assembly	45	1.37e-07	8.82e-07	0.653	-1.85e-01	-5.44e-01	-2.88e-01	-3.93e-02	-1.05e-01	-0.036800	3.17e-02	2.77e-10	8.28e-04	6.48e-01	2.22e-01	6.69e-01
Signaling by PDGFRA extracellular domain mutants	12	7.42e-02	1.20e-01	0.653	-1.14e-01	1.72e-01	3.67e-01	1.00e-01	-2.50e-02	0.488000	4.93e-01	3.01e-01	2.77e-02	5.47e-01	8.81e-01	3.42e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	7.42e-02	1.20e-01	0.653	-1.14e-01	1.72e-01	3.67e-01	1.00e-01	-2.50e-02	0.488000	4.93e-01	3.01e-01	2.77e-02	5.47e-01	8.81e-01	3.42e-03
Response to elevated platelet cytosolic Ca2+	108	7.37e-19	1.29e-17	0.652	-2.71e-01	-3.73e-01	2.11e-01	-1.16e-01	-3.02e-01	0.252000	1.09e-06	2.10e-11	1.57e-04	3.67e-02	5.67e-08	6.17e-06
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.23e-02	2.69e-02	0.651	-2.98e-01	3.58e-01	3.49e-01	2.61e-02	-7.41e-02	0.281000	8.65e-02	3.97e-02	4.53e-02	8.81e-01	6.70e-01	1.07e-01
Condensation of Prophase Chromosomes	27	9.87e-05	3.87e-04	0.651	-1.76e-01	-4.42e-01	1.71e-01	1.19e-02	-2.90e-01	0.289000	1.13e-01	6.97e-05	1.24e-01	9.15e-01	9.13e-03	9.31e-03
Regulation of PTEN mRNA translation	12	1.49e-02	3.15e-02	0.650	-2.06e-01	3.23e-01	2.46e-01	1.77e-01	8.34e-02	0.421000	2.18e-01	5.26e-02	1.40e-01	2.87e-01	6.17e-01	1.16e-02
Translesion synthesis by POLI	17	6.35e-03	1.53e-02	0.649	-1.60e-01	-4.47e-01	-4.33e-01	2.58e-02	8.80e-02	-0.014100	2.55e-01	1.42e-03	1.97e-03	8.54e-01	5.30e-01	9.20e-01
Scavenging by Class A Receptors	10	5.99e-03	1.46e-02	0.649	-1.80e-01	-4.69e-01	3.23e-01	-4.82e-02	-2.50e-01	0.005870	3.23e-01	1.03e-02	7.65e-02	7.92e-01	1.71e-01	9.74e-01
CS/DS degradation	9	1.54e-01	2.14e-01	0.649	-3.73e-01	-1.16e-01	-2.64e-01	-1.71e-01	3.10e-02	-0.412000	5.28e-02	5.46e-01	1.71e-01	3.75e-01	8.72e-01	3.25e-02
Synthesis of 15-eicosatetraenoic acid derivatives	6	5.00e-01	5.57e-01	0.649	-1.26e-01	-2.60e-01	-2.50e-01	-3.93e-01	-1.42e-01	-0.316000	5.93e-01	2.69e-01	2.88e-01	9.51e-02	5.46e-01	1.80e-01
Base-Excision Repair, AP Site Formation	28	1.18e-05	5.53e-05	0.649	-8.10e-02	-5.72e-01	-5.69e-02	8.33e-02	-2.51e-01	0.120000	4.58e-01	1.61e-07	6.02e-01	4.46e-01	2.17e-02	2.72e-01
RNA Polymerase III Transcription Termination	22	3.46e-03	9.07e-03	0.648	-1.45e-01	-5.01e-01	-3.21e-01	1.41e-02	-1.68e-01	-0.129000	2.38e-01	4.69e-05	9.13e-03	9.09e-01	1.72e-01	2.96e-01
p75NTR negatively regulates cell cycle via SC1	5	3.21e-01	3.89e-01	0.648	-3.79e-01	-3.53e-01	1.31e-01	1.19e-01	2.76e-02	0.345000	1.42e-01	1.71e-01	6.12e-01	6.44e-01	9.15e-01	1.81e-01
Degradation of DVL	43	5.35e-09	4.26e-08	0.648	-1.91e-01	-5.01e-01	6.83e-02	3.85e-02	-1.64e-01	0.315000	3.05e-02	1.27e-08	4.38e-01	6.63e-01	6.28e-02	3.59e-04
Crosslinking of collagen fibrils	12	1.41e-02	3.00e-02	0.648	-4.61e-02	1.48e-01	4.30e-03	-3.61e-01	-2.33e-01	-0.459000	7.82e-01	3.76e-01	9.79e-01	3.05e-02	1.62e-01	5.87e-03
Stabilization of p53	43	6.14e-09	4.82e-08	0.648	-2.24e-01	-5.14e-01	-9.85e-03	-1.12e-02	-1.19e-01	0.301000	1.12e-02	5.45e-09	9.11e-01	8.99e-01	1.76e-01	6.30e-04
IRAK1 recruits IKK complex	14	1.55e-01	2.15e-01	0.645	-3.98e-01	-2.89e-01	-5.40e-02	-2.84e-01	-3.02e-01	0.009100	9.96e-03	6.15e-02	7.26e-01	6.63e-02	5.04e-02	9.53e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	1.55e-01	2.15e-01	0.645	-3.98e-01	-2.89e-01	-5.40e-02	-2.84e-01	-3.02e-01	0.009100	9.96e-03	6.15e-02	7.26e-01	6.63e-02	5.04e-02	9.53e-01
Transcriptional regulation of testis differentiation	5	4.58e-01	5.19e-01	0.644	2.77e-01	2.90e-01	-6.88e-02	-3.82e-02	7.47e-02	-0.492000	2.83e-01	2.61e-01	7.90e-01	8.82e-01	7.72e-01	5.65e-02
Insulin receptor recycling	24	5.31e-04	1.71e-03	0.644	-2.95e-01	-3.02e-01	2.80e-01	-9.49e-02	-3.48e-01	0.168000	1.25e-02	1.03e-02	1.74e-02	4.21e-01	3.16e-03	1.55e-01
Synthesis of UDP-N-acetyl-glucosamine	8	4.79e-02	8.36e-02	0.644	-3.15e-01	1.86e-02	-5.05e-01	8.49e-02	-4.97e-02	-0.225000	1.23e-01	9.27e-01	1.34e-02	6.78e-01	8.08e-01	2.70e-01
Activation of SMO	13	9.42e-02	1.46e-01	0.644	1.51e-01	4.02e-01	1.86e-01	3.47e-01	2.39e-01	0.135000	3.45e-01	1.21e-02	2.46e-01	3.01e-02	1.35e-01	4.00e-01
Telomere C-strand synthesis initiation	13	2.76e-02	5.31e-02	0.644	-1.02e-01	-2.13e-01	-4.09e-01	3.72e-01	2.29e-01	-0.024200	5.25e-01	1.83e-01	1.06e-02	2.04e-02	1.53e-01	8.80e-01
Orc1 removal from chromatin	58	9.08e-14	1.15e-12	0.644	-1.32e-01	-5.13e-01	2.15e-02	7.68e-02	-1.11e-01	0.339000	8.10e-02	1.40e-11	7.77e-01	3.12e-01	1.44e-01	7.80e-06
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	4.54e-01	5.16e-01	0.643	3.48e-01	2.62e-01	3.65e-01	2.49e-01	8.24e-02	0.147000	8.82e-02	2.00e-01	7.34e-02	2.22e-01	6.86e-01	4.72e-01
Signaling by Erythropoietin	24	1.04e-05	4.96e-05	0.643	-1.49e-01	3.65e-01	3.61e-01	2.43e-01	5.43e-02	0.256000	2.07e-01	1.95e-03	2.21e-03	3.93e-02	6.45e-01	3.00e-02
Miro GTPase Cycle	8	3.38e-01	4.04e-01	0.643	-1.94e-01	-2.40e-01	2.58e-01	-1.11e-01	-4.57e-01	0.172000	3.41e-01	2.39e-01	2.06e-01	5.87e-01	2.51e-02	4.00e-01
IFNG signaling activates MAPKs	8	3.31e-01	3.98e-01	0.642	-4.26e-01	-1.66e-02	8.17e-02	-3.51e-01	-2.90e-01	0.127000	3.70e-02	9.35e-01	6.89e-01	8.53e-02	1.56e-01	5.33e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	6.16e-01	6.65e-01	0.641	-8.23e-02	-2.45e-01	-4.01e-01	-5.32e-02	2.40e-01	-0.351000	7.50e-01	3.42e-01	1.20e-01	8.37e-01	3.53e-01	1.74e-01
Aerobic respiration and respiratory electron transport	245	9.08e-50	7.26e-48	0.641	-1.76e-01	-5.48e-01	-2.73e-01	1.97e-02	-6.50e-02	0.013900	2.10e-06	1.28e-49	1.97e-13	5.96e-01	7.97e-02	7.08e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	4.02e-01	4.67e-01	0.641	-2.13e-01	-2.14e-02	2.59e-01	-8.48e-02	-4.71e-01	0.262000	3.66e-01	9.28e-01	2.73e-01	7.19e-01	4.56e-02	2.67e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	3.32e-02	6.21e-02	0.639	-2.38e-01	-2.96e-01	1.21e-01	-4.47e-01	-1.98e-01	0.105000	1.24e-01	5.52e-02	4.33e-01	3.78e-03	2.00e-01	4.98e-01
Degradation of AXIN	42	2.99e-08	2.16e-07	0.639	-2.49e-01	-4.85e-01	2.07e-02	2.28e-02	-1.25e-01	0.307000	5.23e-03	5.30e-08	8.16e-01	7.98e-01	1.61e-01	5.68e-04
Acyl chain remodelling of PI	10	2.06e-01	2.72e-01	0.638	-2.35e-01	6.25e-02	2.34e-01	-4.45e-01	-2.33e-01	0.200000	1.97e-01	7.32e-01	2.00e-01	1.48e-02	2.01e-01	2.74e-01
Defective C1GALT1C1 causes TNPS	9	2.95e-01	3.65e-01	0.638	1.25e-01	3.49e-01	4.58e-01	-8.18e-02	-4.64e-03	0.229000	5.15e-01	6.99e-02	1.73e-02	6.71e-01	9.81e-01	2.33e-01
2-LTR circle formation	7	1.57e-01	2.17e-01	0.637	-2.37e-01	-2.71e-01	-3.29e-01	1.66e-01	2.80e-01	0.250000	2.78e-01	2.14e-01	1.31e-01	4.47e-01	2.00e-01	2.52e-01
Role of ABL in ROBO-SLIT signaling	6	1.52e-01	2.12e-01	0.637	-3.12e-01	2.01e-01	4.02e-01	1.51e-01	-1.07e-01	0.270000	1.86e-01	3.94e-01	8.85e-02	5.21e-01	6.50e-01	2.53e-01
The activation of arylsulfatases	10	3.19e-01	3.87e-01	0.637	-3.64e-01	-3.26e-01	-2.68e-01	-1.48e-01	-2.33e-01	-0.139000	4.62e-02	7.46e-02	1.42e-01	4.18e-01	2.02e-01	4.48e-01
Autodegradation of Cdh1 by Cdh1:APC/C	54	1.50e-10	1.42e-09	0.637	-2.23e-01	-5.33e-01	-6.21e-02	-4.91e-02	-1.29e-01	0.221000	4.61e-03	1.24e-11	4.30e-01	5.33e-01	1.00e-01	4.91e-03
Signaling by ROBO receptors	188	5.61e-35	1.92e-33	0.637	-2.10e-01	-5.30e-01	-2.77e-01	-2.78e-02	-5.76e-02	-0.002970	7.02e-07	4.35e-36	5.63e-11	5.11e-01	1.73e-01	9.44e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	3.54e-02	6.55e-02	0.636	2.41e-02	3.33e-01	1.24e-01	-1.36e-01	-5.07e-01	-0.053000	9.12e-01	1.27e-01	5.70e-01	5.33e-01	2.02e-02	8.08e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	9.63e-02	1.48e-01	0.636	2.31e-01	3.42e-01	-1.87e-01	1.10e-03	3.49e-01	-0.278000	1.67e-01	4.04e-02	2.61e-01	9.95e-01	3.61e-02	9.56e-02
TGFBR3 PTM regulation	10	2.06e-02	4.11e-02	0.635	-4.70e-01	-2.49e-01	4.40e-02	1.46e-01	-2.99e-01	0.087600	1.01e-02	1.72e-01	8.09e-01	4.24e-01	1.01e-01	6.31e-01
Protein lipoylation	10	7.07e-02	1.15e-01	0.635	-2.82e-01	-3.72e-01	-3.77e-01	-6.38e-02	1.09e-01	0.165000	1.23e-01	4.17e-02	3.91e-02	7.27e-01	5.51e-01	3.66e-01
Signaling by FLT3 ITD and TKD mutants	15	8.62e-03	1.97e-02	0.634	-1.39e-01	2.02e-01	4.97e-01	8.24e-02	-1.22e-01	0.271000	3.52e-01	1.75e-01	8.67e-04	5.81e-01	4.15e-01	6.89e-02
Biotin transport and metabolism	11	1.43e-01	2.02e-01	0.634	-9.73e-02	-1.98e-01	-4.33e-01	2.65e-01	2.70e-01	-0.149000	5.76e-01	2.56e-01	1.28e-02	1.27e-01	1.21e-01	3.94e-01
Deposition of new CENPA-containing nucleosomes at the centromere	37	6.09e-07	3.52e-06	0.634	-7.82e-02	-5.08e-01	-2.25e-02	3.98e-04	-3.00e-01	0.218000	4.10e-01	9.03e-08	8.13e-01	9.97e-01	1.59e-03	2.16e-02
Nucleosome assembly	37	6.09e-07	3.52e-06	0.634	-7.82e-02	-5.08e-01	-2.25e-02	3.98e-04	-3.00e-01	0.218000	4.10e-01	9.03e-08	8.13e-01	9.97e-01	1.59e-03	2.16e-02
COPI-independent Golgi-to-ER retrograde traffic	45	4.89e-07	2.88e-06	0.634	-2.25e-01	-2.31e-01	2.74e-01	9.11e-03	-2.86e-01	0.375000	8.93e-03	7.36e-03	1.45e-03	9.16e-01	8.87e-04	1.36e-05
ALK mutants bind TKIs	11	8.44e-02	1.33e-01	0.634	-1.37e-01	2.01e-01	3.30e-01	1.65e-01	1.31e-01	0.435000	4.32e-01	2.48e-01	5.78e-02	3.43e-01	4.52e-01	1.25e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	2.08e-02	4.15e-02	0.633	-2.21e-01	-1.78e-01	2.93e-01	5.72e-02	-4.49e-01	0.175000	1.68e-01	2.66e-01	6.78e-02	7.21e-01	5.10e-03	2.75e-01
Small interfering RNA (siRNA) biogenesis	9	4.44e-02	7.84e-02	0.633	-5.61e-01	7.45e-02	-7.49e-02	-1.29e-01	-7.65e-02	0.231000	3.59e-03	6.99e-01	6.97e-01	5.03e-01	6.91e-01	2.31e-01
Integration of provirus	9	1.17e-01	1.73e-01	0.632	-3.04e-01	-2.64e-01	-4.20e-01	1.17e-01	1.91e-01	0.106000	1.14e-01	1.71e-01	2.90e-02	5.44e-01	3.21e-01	5.81e-01
Anti-inflammatory response favouring Leishmania parasite infection	130	3.53e-29	9.69e-28	0.632	-3.20e-02	-2.30e-01	2.45e-01	2.58e-01	-2.91e-01	0.367000	5.29e-01	6.20e-06	1.43e-06	3.83e-07	9.72e-09	4.58e-13
Leishmania parasite growth and survival	130	3.53e-29	9.69e-28	0.632	-3.20e-02	-2.30e-01	2.45e-01	2.58e-01	-2.91e-01	0.367000	5.29e-01	6.20e-06	1.43e-06	3.83e-07	9.72e-09	4.58e-13
Signaling by CSF1 (M-CSF) in myeloid cells	30	3.93e-06	2.03e-05	0.632	-1.15e-01	2.45e-01	2.58e-01	3.09e-01	7.45e-02	0.398000	2.75e-01	2.03e-02	1.43e-02	3.38e-03	4.80e-01	1.61e-04
Synthesis of 5-eicosatetraenoic acids	7	3.15e-01	3.84e-01	0.631	-4.37e-02	-7.63e-02	-1.13e-01	-3.21e-01	-3.74e-01	-0.367000	8.41e-01	7.27e-01	6.03e-01	1.42e-01	8.64e-02	9.28e-02
Telomere C-strand (Lagging Strand) Synthesis	34	5.12e-06	2.60e-05	0.631	5.05e-02	-2.76e-01	-3.63e-01	3.58e-01	2.41e-01	-0.028800	6.10e-01	5.32e-03	2.44e-04	3.01e-04	1.52e-02	7.71e-01
SOS-mediated signalling	7	2.14e-01	2.81e-01	0.630	-1.63e-01	5.23e-02	4.43e-01	-3.20e-01	-2.64e-01	0.011700	4.56e-01	8.11e-01	4.25e-02	1.43e-01	2.27e-01	9.57e-01
Nectin/Necl trans heterodimerization	5	5.06e-01	5.62e-01	0.630	-3.93e-03	4.52e-01	2.86e-01	1.27e-01	2.96e-01	0.085700	9.88e-01	8.03e-02	2.68e-01	6.23e-01	2.51e-01	7.40e-01
Erythropoietin activates STAT5	6	8.39e-02	1.32e-01	0.630	-5.43e-01	6.71e-03	2.26e-01	-3.95e-02	1.55e-01	0.160000	2.13e-02	9.77e-01	3.38e-01	8.67e-01	5.12e-01	4.96e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	5.31e-04	1.71e-03	0.630	-1.42e-01	-4.57e-01	-3.50e-01	7.00e-02	-1.45e-01	-0.137000	1.94e-01	2.81e-05	1.33e-03	5.21e-01	1.84e-01	2.09e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	2.31e-03	6.31e-03	0.630	1.08e-02	-4.78e-01	-1.39e-01	2.74e-01	1.78e-01	0.205000	9.44e-01	1.97e-03	3.69e-01	7.57e-02	2.50e-01	1.84e-01
CDH11 homotypic and heterotypic interactions	5	3.34e-01	4.01e-01	0.629	-9.48e-02	4.24e-01	6.63e-02	2.20e-01	3.54e-01	-0.169000	7.13e-01	1.00e-01	7.97e-01	3.94e-01	1.71e-01	5.12e-01
CDK-mediated phosphorylation and removal of Cdc6	60	4.00e-12	4.37e-11	0.629	-2.12e-01	-5.23e-01	5.85e-03	-1.60e-02	-1.33e-01	0.243000	4.46e-03	2.40e-12	9.37e-01	8.30e-01	7.53e-02	1.13e-03
Regulation of APC/C activators between G1/S and early anaphase	68	1.70e-14	2.31e-13	0.628	-1.69e-01	-5.09e-01	2.64e-02	3.96e-02	-1.36e-01	0.293000	1.62e-02	3.77e-13	7.07e-01	5.73e-01	5.29e-02	2.94e-05
Translesion synthesis by REV1	16	8.90e-03	2.02e-02	0.627	-1.12e-01	-4.48e-01	-4.02e-01	8.55e-02	1.02e-01	0.019900	4.37e-01	1.90e-03	5.42e-03	5.54e-01	4.82e-01	8.90e-01
Proton-coupled monocarboxylate transport	6	3.77e-01	4.42e-01	0.626	-1.66e-01	-5.48e-02	3.37e-01	5.66e-02	-4.26e-01	0.250000	4.81e-01	8.16e-01	1.52e-01	8.10e-01	7.06e-02	2.88e-01
Mismatch Repair	15	1.57e-03	4.48e-03	0.626	1.13e-03	-4.28e-01	-9.47e-02	3.16e-01	2.07e-01	0.239000	9.94e-01	4.11e-03	5.25e-01	3.44e-02	1.65e-01	1.09e-01
Initiation of Nuclear Envelope (NE) Reformation	19	3.23e-03	8.55e-03	0.625	-2.37e-01	-2.88e-01	2.27e-01	1.29e-01	-2.20e-01	0.368000	7.33e-02	2.95e-02	8.73e-02	3.32e-01	9.75e-02	5.50e-03
Carnitine shuttle	12	4.46e-02	7.85e-02	0.624	-5.21e-02	1.08e-01	-7.20e-02	3.77e-01	4.74e-01	-0.059500	7.55e-01	5.17e-01	6.66e-01	2.37e-02	4.47e-03	7.21e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	9.34e-05	3.70e-04	0.624	-7.28e-02	-4.53e-01	-3.21e-01	1.54e-01	2.17e-01	-0.067600	5.29e-01	8.83e-05	5.47e-03	1.82e-01	6.06e-02	5.59e-01
p75NTR recruits signalling complexes	12	1.17e-01	1.73e-01	0.623	-3.25e-01	-4.21e-01	-1.64e-01	-1.10e-01	-1.35e-01	-0.219000	5.13e-02	1.15e-02	3.25e-01	5.08e-01	4.17e-01	1.88e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	2.24e-13	2.76e-12	0.623	-1.29e-01	-4.51e-01	1.40e-01	-2.11e-02	-2.11e-01	0.323000	6.33e-02	9.47e-11	4.41e-02	7.62e-01	2.44e-03	3.54e-06
CREB3 factors activate genes	6	3.77e-01	4.42e-01	0.623	-2.97e-01	-2.39e-01	-3.82e-01	-5.21e-02	-2.83e-01	-0.118000	2.08e-01	3.11e-01	1.05e-01	8.25e-01	2.29e-01	6.18e-01
Intrinsic Pathway of Fibrin Clot Formation	15	9.15e-03	2.06e-02	0.622	6.76e-02	-3.53e-01	2.01e-01	-2.08e-01	-2.96e-01	0.293000	6.51e-01	1.78e-02	1.78e-01	1.63e-01	4.74e-02	4.92e-02
Androgen biosynthesis	5	1.97e-01	2.63e-01	0.622	-1.54e-01	-4.80e-01	4.74e-02	-3.26e-01	3.09e-02	0.151000	5.52e-01	6.29e-02	8.54e-01	2.07e-01	9.05e-01	5.58e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	1.61e-03	4.58e-03	0.621	-1.20e-01	-4.55e-01	1.07e-01	-6.30e-02	-2.96e-01	0.248000	3.19e-01	1.57e-04	3.74e-01	6.01e-01	1.41e-02	3.98e-02
Formation of annular gap junctions	10	2.53e-03	6.84e-03	0.621	-3.63e-01	-1.40e-01	1.82e-01	4.16e-01	-8.68e-02	0.143000	4.69e-02	4.42e-01	3.20e-01	2.26e-02	6.35e-01	4.35e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	9.24e-04	2.80e-03	0.620	-1.35e-01	-4.39e-01	-3.59e-01	9.56e-02	-1.20e-01	-0.144000	2.25e-01	7.75e-05	1.26e-03	3.90e-01	2.81e-01	1.95e-01
Telomere Extension By Telomerase	23	5.57e-05	2.33e-04	0.620	-9.41e-02	-4.20e-01	7.34e-02	3.25e-01	-2.06e-01	0.212000	4.35e-01	4.89e-04	5.42e-01	6.90e-03	8.68e-02	7.84e-02
Regulation of CDH11 function	9	3.45e-01	4.11e-01	0.620	2.12e-01	4.57e-01	2.56e-01	2.01e-01	1.48e-01	0.049800	2.70e-01	1.77e-02	1.83e-01	2.96e-01	4.42e-01	7.96e-01
Formation of Fibrin Clot (Clotting Cascade)	26	2.16e-03	5.97e-03	0.619	-1.59e-02	-1.56e-01	2.76e-01	-2.59e-01	-3.48e-01	0.307000	8.88e-01	1.68e-01	1.50e-02	2.24e-02	2.12e-03	6.69e-03
Relaxin receptors	5	1.49e-01	2.09e-01	0.618	5.30e-02	5.64e-02	5.95e-01	-1.44e-01	-2.19e-02	0.017000	8.37e-01	8.27e-01	2.12e-02	5.77e-01	9.32e-01	9.47e-01
Suppression of apoptosis	7	7.72e-02	1.24e-01	0.617	4.70e-02	-1.56e-01	2.30e-01	4.19e-01	-3.52e-01	0.045200	8.30e-01	4.76e-01	2.92e-01	5.46e-02	1.07e-01	8.36e-01
Cobalamin (Cbl) metabolism	7	1.63e-01	2.25e-01	0.617	-2.11e-01	2.07e-02	5.69e-03	8.31e-02	2.61e-01	0.511000	3.34e-01	9.24e-01	9.79e-01	7.04e-01	2.32e-01	1.92e-02
Fcgamma receptor (FCGR) dependent phagocytosis	146	9.67e-33	3.09e-31	0.617	-7.43e-02	-2.13e-01	2.25e-01	2.88e-01	-2.37e-01	0.374000	1.21e-01	8.52e-06	2.60e-06	1.76e-09	8.01e-07	5.92e-15
Thyroxine biosynthesis	5	4.55e-01	5.16e-01	0.617	1.83e-01	2.41e-01	-1.25e-01	-2.62e-01	8.34e-02	-0.444000	4.80e-01	3.50e-01	6.27e-01	3.11e-01	7.47e-01	8.52e-02
PI-3K cascade:FGFR3	10	4.32e-02	7.68e-02	0.616	-3.65e-01	2.30e-01	2.64e-01	-1.23e-01	-2.63e-01	0.200000	4.57e-02	2.08e-01	1.48e-01	5.01e-01	1.50e-01	2.74e-01
Anchoring fibril formation	7	5.82e-02	9.89e-02	0.614	-1.74e-01	2.19e-01	3.30e-01	-2.13e-01	-2.46e-01	-0.290000	4.26e-01	3.16e-01	1.30e-01	3.30e-01	2.59e-01	1.83e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	2.20e-02	4.36e-02	0.614	-5.10e-03	3.86e-01	1.86e-01	3.69e-02	2.90e-01	0.328000	9.72e-01	7.45e-03	1.98e-01	7.98e-01	4.46e-02	2.29e-02
IRAK4 deficiency (TLR2/4)	15	3.91e-03	1.00e-02	0.614	-4.13e-01	2.60e-01	1.39e-01	-1.38e-01	5.86e-02	0.311000	5.58e-03	8.10e-02	3.50e-01	3.54e-01	6.94e-01	3.73e-02
Uptake of dietary cobalamins into enterocytes	5	5.76e-01	6.27e-01	0.614	2.40e-01	-5.56e-03	1.40e-01	3.19e-01	2.91e-01	0.335000	3.52e-01	9.83e-01	5.87e-01	2.17e-01	2.60e-01	1.94e-01
Pexophagy	10	1.79e-01	2.43e-01	0.613	-2.14e-01	-3.98e-01	-3.68e-01	1.09e-01	1.52e-01	-0.040900	2.42e-01	2.94e-02	4.42e-02	5.49e-01	4.06e-01	8.23e-01
Regulation of RUNX3 expression and activity	45	6.12e-08	4.08e-07	0.613	-2.22e-01	-4.94e-01	2.23e-02	-5.22e-04	-1.55e-01	0.240000	1.01e-02	9.68e-09	7.95e-01	9.95e-01	7.15e-02	5.42e-03
DNA strand elongation	32	1.65e-06	9.08e-06	0.613	1.88e-01	-3.21e-01	-2.31e-01	3.63e-01	2.17e-01	0.068800	6.55e-02	1.70e-03	2.37e-02	3.81e-04	3.33e-02	5.01e-01
Regulation of RAS by GAPs	55	1.05e-09	9.06e-09	0.612	-1.92e-01	-4.09e-01	1.15e-01	4.16e-02	-1.82e-01	0.350000	1.36e-02	1.51e-07	1.39e-01	5.93e-01	1.98e-02	7.09e-06
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.16e-02	2.56e-02	0.612	2.44e-02	-2.18e-02	1.36e-01	3.71e-01	1.09e-01	0.452000	8.66e-01	8.80e-01	3.45e-01	1.01e-02	4.49e-01	1.73e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	2.61e-03	7.01e-03	0.611	-1.90e-01	-4.77e-01	-2.60e-01	1.72e-01	-6.53e-02	-0.087100	1.22e-01	1.08e-04	3.44e-02	1.62e-01	5.96e-01	4.79e-01
HDL remodeling	6	1.03e-01	1.57e-01	0.611	2.08e-01	-1.28e-01	2.67e-01	4.55e-01	-9.58e-03	-0.186000	3.78e-01	5.87e-01	2.57e-01	5.37e-02	9.68e-01	4.29e-01
Somitogenesis	41	3.85e-08	2.70e-07	0.611	-1.46e-01	-4.32e-01	1.45e-01	6.76e-02	-1.13e-01	0.356000	1.06e-01	1.68e-06	1.09e-01	4.54e-01	2.12e-01	8.02e-05
Spry regulation of FGF signaling	16	3.91e-02	7.15e-02	0.611	-3.69e-01	-2.93e-01	8.79e-02	-3.94e-02	-3.14e-01	0.206000	1.05e-02	4.24e-02	5.43e-01	7.85e-01	2.96e-02	1.54e-01
G1/S DNA Damage Checkpoints	54	1.75e-10	1.64e-09	0.608	-2.07e-01	-4.95e-01	4.17e-02	1.69e-02	-1.15e-01	0.257000	8.49e-03	3.00e-10	5.96e-01	8.30e-01	1.42e-01	1.11e-03
MyD88 deficiency (TLR2/4)	14	8.74e-03	1.99e-02	0.608	-3.81e-01	2.85e-01	1.63e-01	-1.48e-01	7.49e-02	0.299000	1.36e-02	6.52e-02	2.90e-01	3.39e-01	6.27e-01	5.31e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	1.25e-02	2.73e-02	0.608	2.77e-01	7.00e-02	1.88e-01	4.87e-01	1.58e-02	0.120000	4.19e-02	6.07e-01	1.67e-01	3.44e-04	9.08e-01	3.79e-01
Formation of tubulin folding intermediates by CCT/TriC	21	2.64e-03	7.07e-03	0.607	-9.69e-02	-4.61e-01	1.54e-01	-6.49e-02	-2.90e-01	0.187000	4.42e-01	2.53e-04	2.23e-01	6.07e-01	2.14e-02	1.38e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	1.96e-03	5.45e-03	0.607	-1.38e-02	-1.68e-01	3.27e-01	2.89e-01	-1.81e-01	0.343000	9.15e-01	1.93e-01	1.14e-02	2.53e-02	1.61e-01	7.92e-03
Synthesis of PE	12	1.42e-01	2.02e-01	0.607	-2.86e-01	-1.42e-01	-2.11e-01	-2.20e-01	-3.08e-01	-0.282000	8.63e-02	3.94e-01	2.06e-01	1.87e-01	6.51e-02	9.13e-02
Early Phase of HIV Life Cycle	14	6.04e-02	1.02e-01	0.607	-1.85e-01	-3.01e-01	-3.93e-01	1.94e-01	2.18e-01	-0.068800	2.32e-01	5.13e-02	1.10e-02	2.08e-01	1.58e-01	6.56e-01
Assembly of the pre-replicative complex	87	1.11e-16	1.74e-15	0.607	-1.70e-01	-4.99e-01	-2.68e-02	5.16e-03	-1.50e-01	0.259000	6.03e-03	7.79e-16	6.65e-01	9.34e-01	1.56e-02	3.01e-05
Lysosphingolipid and LPA receptors	11	2.45e-01	3.14e-01	0.605	4.07e-01	2.28e-01	3.31e-02	3.61e-01	1.30e-01	0.021600	1.94e-02	1.90e-01	8.49e-01	3.81e-02	4.55e-01	9.01e-01
TNFR1-mediated ceramide production	6	3.51e-01	4.16e-01	0.605	-3.01e-02	-2.77e-01	-2.79e-01	2.11e-01	4.07e-01	-0.023700	8.98e-01	2.39e-01	2.37e-01	3.71e-01	8.42e-02	9.20e-01
HDR through MMEJ (alt-NHEJ)	12	1.08e-01	1.63e-01	0.605	9.46e-02	2.35e-03	-1.12e-01	4.62e-01	3.31e-01	0.146000	5.70e-01	9.89e-01	5.03e-01	5.59e-03	4.72e-02	3.81e-01
Defective pyroptosis	27	8.54e-05	3.39e-04	0.604	-1.60e-01	-5.40e-01	-1.09e-02	3.17e-02	-1.50e-01	0.157000	1.50e-01	1.20e-06	9.22e-01	7.75e-01	1.76e-01	1.57e-01
TYSND1 cleaves peroxisomal proteins	7	4.94e-01	5.51e-01	0.604	-3.56e-01	-4.07e-01	-2.58e-01	-7.00e-02	5.73e-03	0.032100	1.03e-01	6.24e-02	2.37e-01	7.48e-01	9.79e-01	8.83e-01
Class I peroxisomal membrane protein import	20	3.78e-03	9.75e-03	0.604	-2.57e-01	-3.54e-01	-3.51e-01	1.14e-01	1.76e-01	0.076200	4.66e-02	6.10e-03	6.50e-03	3.77e-01	1.74e-01	5.55e-01
Degradation of cysteine and homocysteine	12	1.22e-01	1.79e-01	0.603	-1.36e-01	-3.23e-01	-3.33e-01	2.25e-02	1.80e-01	-0.312000	4.15e-01	5.30e-02	4.60e-02	8.93e-01	2.80e-01	6.10e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	3.10e-11	3.13e-10	0.603	-1.90e-01	-4.99e-01	-2.57e-02	-2.27e-02	-1.23e-01	0.248000	1.03e-02	1.48e-11	7.29e-01	7.59e-01	9.61e-02	8.13e-04
Amyloid fiber formation	51	2.91e-07	1.77e-06	0.602	-1.36e-01	-4.12e-01	5.83e-03	-4.09e-02	-4.03e-01	0.098800	9.25e-02	3.45e-07	9.43e-01	6.13e-01	6.25e-07	2.22e-01
Protein localization	157	6.09e-25	1.24e-23	0.601	-2.05e-01	-4.73e-01	-3.08e-01	1.21e-02	-7.17e-03	-0.033100	9.70e-06	1.35e-24	2.67e-11	7.93e-01	8.77e-01	4.74e-01
PI3K/AKT activation	8	2.51e-01	3.21e-01	0.601	-1.74e-01	1.04e-01	4.64e-01	-1.95e-01	-2.10e-01	0.150000	3.95e-01	6.10e-01	2.31e-02	3.39e-01	3.05e-01	4.62e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	2.78e-03	7.41e-03	0.601	-2.17e-01	-5.00e-01	-1.75e-01	-4.93e-02	-1.38e-01	0.107000	6.60e-02	2.22e-05	1.38e-01	6.76e-01	2.41e-01	3.65e-01
NIK–>noncanonical NF-kB signaling	46	1.60e-08	1.21e-07	0.600	-2.18e-01	-4.75e-01	1.49e-04	1.41e-02	-7.83e-02	0.284000	1.04e-02	2.47e-08	9.99e-01	8.69e-01	3.58e-01	8.50e-04
Regulated proteolysis of p75NTR	11	4.04e-02	7.34e-02	0.600	-3.91e-01	-1.85e-01	2.07e-01	-1.09e-02	-3.58e-01	0.045200	2.49e-02	2.88e-01	2.34e-01	9.50e-01	3.97e-02	7.95e-01
TRAF3-dependent IRF activation pathway	13	1.47e-01	2.07e-01	0.600	1.81e-01	2.64e-01	3.60e-02	4.35e-01	2.46e-01	0.083500	2.58e-01	9.90e-02	8.22e-01	6.67e-03	1.25e-01	6.02e-01
Interleukin-7 signaling	21	1.58e-02	3.32e-02	0.599	1.35e-01	4.36e-01	3.34e-01	9.03e-02	2.66e-02	0.173000	2.84e-01	5.39e-04	8.01e-03	4.74e-01	8.33e-01	1.70e-01
Smooth Muscle Contraction	34	1.56e-04	5.85e-04	0.599	-2.33e-01	-2.77e-01	2.73e-01	-9.77e-02	-2.69e-01	0.266000	1.89e-02	5.16e-03	5.80e-03	3.24e-01	6.65e-03	7.19e-03
Biosynthesis of E-series 18(S)-resolvins	5	3.67e-01	4.33e-01	0.598	1.23e-03	1.10e-01	3.46e-01	-4.71e-01	-4.30e-02	0.037900	9.96e-01	6.70e-01	1.80e-01	6.80e-02	8.68e-01	8.83e-01
RNA Polymerase I Transcription Termination	30	1.80e-03	5.09e-03	0.598	-2.20e-01	-4.52e-01	-2.80e-01	-5.29e-02	-6.52e-02	-0.138000	3.68e-02	1.83e-05	7.92e-03	6.16e-01	5.36e-01	1.90e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	3.96e-06	2.04e-05	0.597	-4.41e-01	-3.14e-01	5.89e-03	6.92e-02	-1.76e-01	0.167000	6.44e-06	1.30e-03	9.52e-01	4.79e-01	7.08e-02	8.76e-02
Downregulation of ERBB4 signaling	8	3.56e-01	4.22e-01	0.597	-3.46e-01	-3.82e-01	-1.51e-01	-1.52e-01	-4.25e-02	0.208000	9.01e-02	6.16e-02	4.60e-01	4.58e-01	8.35e-01	3.08e-01
Apoptotic factor-mediated response	19	9.27e-03	2.08e-02	0.596	-3.33e-01	-4.03e-01	-2.02e-01	1.44e-02	-1.68e-02	0.202000	1.20e-02	2.33e-03	1.27e-01	9.13e-01	8.99e-01	1.28e-01
Leading Strand Synthesis	14	6.92e-03	1.65e-02	0.596	5.40e-02	-3.24e-01	-2.77e-01	1.02e-01	3.84e-01	-0.115000	7.27e-01	3.57e-02	7.31e-02	5.10e-01	1.28e-02	4.57e-01
Polymerase switching	14	6.92e-03	1.65e-02	0.596	5.40e-02	-3.24e-01	-2.77e-01	1.02e-01	3.84e-01	-0.115000	7.27e-01	3.57e-02	7.31e-02	5.10e-01	1.28e-02	4.57e-01
mRNA Splicing - Minor Pathway	50	3.00e-08	2.16e-07	0.596	-3.36e-02	-4.34e-01	-3.52e-01	1.93e-01	-5.13e-04	-0.066100	6.81e-01	1.11e-07	1.63e-05	1.80e-02	9.95e-01	4.19e-01
Specification of primordial germ cells	6	2.00e-01	2.66e-01	0.596	-1.41e-02	4.07e-01	2.88e-01	-1.74e-01	-4.69e-02	-0.271000	9.52e-01	8.40e-02	2.22e-01	4.61e-01	8.42e-01	2.50e-01
Signaling by PDGFR in disease	19	4.33e-03	1.10e-02	0.596	-1.74e-01	1.46e-01	2.50e-01	1.82e-01	9.95e-03	0.455000	1.88e-01	2.70e-01	5.96e-02	1.69e-01	9.40e-01	5.90e-04
Josephin domain DUBs	10	2.06e-01	2.72e-01	0.595	-2.17e-01	-4.63e-01	6.54e-03	3.50e-02	-2.88e-01	0.095200	2.34e-01	1.13e-02	9.71e-01	8.48e-01	1.15e-01	6.02e-01
Transcription of E2F targets under negative control by DREAM complex	19	6.12e-03	1.48e-02	0.595	1.52e-01	-6.51e-02	1.63e-01	3.42e-01	2.18e-02	0.428000	2.52e-01	6.23e-01	2.18e-01	9.82e-03	8.69e-01	1.25e-03
TP53 Regulates Transcription of Caspase Activators and Caspases	11	6.34e-02	1.06e-01	0.595	-4.48e-02	2.96e-01	-2.26e-01	3.25e-01	3.26e-01	0.024900	7.97e-01	8.89e-02	1.94e-01	6.19e-02	6.10e-02	8.86e-01
Translesion synthesis by POLK	17	1.05e-02	2.34e-02	0.594	-1.40e-01	-4.26e-01	-3.74e-01	4.35e-02	8.88e-02	0.056100	3.17e-01	2.38e-03	7.64e-03	7.56e-01	5.26e-01	6.89e-01
RUNX3 regulates p14-ARF	10	1.12e-01	1.67e-01	0.594	3.07e-01	2.40e-01	2.72e-01	2.13e-01	-2.62e-01	0.113000	9.29e-02	1.88e-01	1.37e-01	2.43e-01	1.52e-01	5.35e-01
SHC1 events in EGFR signaling	11	6.77e-03	1.62e-02	0.594	-2.46e-01	2.31e-01	4.81e-01	-2.87e-02	7.56e-03	0.077400	1.58e-01	1.86e-01	5.70e-03	8.69e-01	9.65e-01	6.57e-01
Reduction of cytosolic Ca++ levels	9	9.86e-02	1.51e-01	0.593	-1.86e-01	3.25e-02	4.14e-01	2.17e-01	-8.21e-02	0.302000	3.33e-01	8.66e-01	3.15e-02	2.59e-01	6.70e-01	1.17e-01
Reelin signalling pathway	5	3.49e-01	4.16e-01	0.593	2.24e-01	7.07e-02	1.67e-01	-9.44e-03	-2.70e-01	0.443000	3.85e-01	7.84e-01	5.17e-01	9.71e-01	2.96e-01	8.65e-02
Polymerase switching on the C-strand of the telomere	26	8.48e-04	2.59e-03	0.593	1.13e-02	-2.57e-01	-3.53e-01	2.60e-01	3.03e-01	-0.052000	9.21e-01	2.35e-02	1.85e-03	2.19e-02	7.55e-03	6.46e-01
Protein hydroxylation	17	2.73e-02	5.25e-02	0.593	-1.61e-01	-4.83e-01	-2.40e-01	1.22e-01	-1.13e-01	-0.086700	2.51e-01	5.66e-04	8.64e-02	3.86e-01	4.18e-01	5.36e-01
Biosynthesis of maresins	5	6.88e-01	7.27e-01	0.593	4.50e-01	1.75e-01	1.64e-01	1.66e-01	2.03e-01	0.151000	8.15e-02	4.99e-01	5.25e-01	5.19e-01	4.32e-01	5.59e-01
ADP signalling through P2Y purinoceptor 12	18	2.10e-02	4.17e-02	0.592	-2.53e-01	-1.37e-01	2.34e-01	2.76e-02	-2.76e-01	0.370000	6.34e-02	3.16e-01	8.62e-02	8.39e-01	4.27e-02	6.59e-03
Digestion and absorption	7	3.11e-01	3.80e-01	0.592	1.83e-01	-1.68e-01	3.06e-01	8.20e-02	-4.26e-01	0.082300	4.03e-01	4.41e-01	1.61e-01	7.07e-01	5.08e-02	7.06e-01
p53-Dependent G1 DNA Damage Response	52	1.65e-09	1.40e-08	0.591	-2.16e-01	-4.85e-01	3.04e-02	1.04e-02	-1.00e-01	0.239000	7.15e-03	1.42e-09	7.04e-01	8.96e-01	2.12e-01	2.90e-03
p53-Dependent G1/S DNA damage checkpoint	52	1.65e-09	1.40e-08	0.591	-2.16e-01	-4.85e-01	3.04e-02	1.04e-02	-1.00e-01	0.239000	7.15e-03	1.42e-09	7.04e-01	8.96e-01	2.12e-01	2.90e-03
Interleukin-23 signaling	7	1.67e-01	2.29e-01	0.591	-8.99e-02	2.12e-01	-2.01e-02	4.63e-01	1.76e-01	0.225000	6.80e-01	3.32e-01	9.27e-01	3.38e-02	4.19e-01	3.02e-01
Physiological factors	9	3.20e-02	6.03e-02	0.591	1.40e-01	3.80e-01	1.53e-01	-1.33e-01	-3.32e-01	0.184000	4.66e-01	4.83e-02	4.27e-01	4.90e-01	8.43e-02	3.39e-01
Maturation of spike protein 9694548	35	1.02e-06	5.77e-06	0.591	-2.22e-01	-2.40e-01	2.10e-01	2.27e-01	-2.32e-01	0.304000	2.29e-02	1.40e-02	3.19e-02	2.02e-02	1.75e-02	1.83e-03
Signaling by the B Cell Receptor (BCR)	149	3.65e-28	9.34e-27	0.590	-4.46e-02	-3.09e-01	1.69e-01	1.74e-01	-2.57e-01	0.355000	3.48e-01	7.18e-11	3.82e-04	2.37e-04	5.94e-08	7.53e-14
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.09e-02	7.39e-02	0.590	-3.19e-01	-4.05e-01	-1.35e-01	5.90e-02	-2.46e-01	-0.019800	2.71e-02	5.02e-03	3.51e-01	6.83e-01	8.85e-02	8.91e-01
APC/C-mediated degradation of cell cycle proteins	75	8.37e-14	1.06e-12	0.590	-1.54e-01	-4.69e-01	3.17e-02	1.75e-02	-1.40e-01	0.288000	2.11e-02	2.01e-12	6.35e-01	7.93e-01	3.64e-02	1.66e-05
Regulation of mitotic cell cycle	75	8.37e-14	1.06e-12	0.590	-1.54e-01	-4.69e-01	3.17e-02	1.75e-02	-1.40e-01	0.288000	2.11e-02	2.01e-12	6.35e-01	7.93e-01	3.64e-02	1.66e-05
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	1.08e-04	4.23e-04	0.589	-1.18e-01	-4.80e-01	8.89e-02	-1.69e-02	-1.82e-01	0.247000	2.78e-01	1.11e-05	4.16e-01	8.77e-01	9.55e-02	2.34e-02
Glycosphingolipid biosynthesis	15	2.63e-02	5.08e-02	0.587	-2.29e-02	3.97e-01	3.23e-01	1.21e-01	-5.40e-02	0.256000	8.78e-01	7.80e-03	3.05e-02	4.17e-01	7.17e-01	8.59e-02
Interactions of Vpr with host cellular proteins	37	1.82e-05	8.28e-05	0.587	-1.45e-01	-1.00e-01	-3.44e-01	3.14e-01	2.11e-01	-0.230000	1.26e-01	2.92e-01	2.95e-04	9.65e-04	2.63e-02	1.56e-02
Antimicrobial peptides	33	5.36e-04	1.72e-03	0.587	5.24e-02	-1.32e-01	3.46e-01	-7.46e-02	-2.77e-01	0.351000	6.02e-01	1.89e-01	5.89e-04	4.58e-01	5.97e-03	4.88e-04
Interleukin-18 signaling	6	2.35e-01	3.05e-01	0.586	8.59e-02	4.49e-01	1.86e-01	-1.44e-01	-2.67e-01	0.090200	7.15e-01	5.69e-02	4.30e-01	5.42e-01	2.57e-01	7.02e-01
Dermatan sulfate biosynthesis	6	4.09e-01	4.75e-01	0.586	-4.39e-01	-9.69e-02	1.20e-01	-2.19e-01	-2.65e-01	-0.098500	6.27e-02	6.81e-01	6.12e-01	3.53e-01	2.62e-01	6.76e-01
Reactions specific to the complex N-glycan synthesis pathway	7	3.19e-01	3.87e-01	0.586	-2.03e-01	-4.36e-01	2.93e-03	1.63e-01	-2.88e-01	0.052700	3.53e-01	4.58e-02	9.89e-01	4.56e-01	1.86e-01	8.09e-01
Synthesis of GDP-mannose	6	2.62e-01	3.32e-01	0.586	5.24e-02	-3.66e-01	-4.07e-02	3.76e-01	-2.16e-01	-0.133000	8.24e-01	1.20e-01	8.63e-01	1.11e-01	3.61e-01	5.74e-01
Ubiquinol biosynthesis	13	1.72e-01	2.35e-01	0.586	-1.65e-01	-4.33e-01	-3.29e-01	1.36e-02	-3.93e-02	-0.138000	3.04e-01	6.89e-03	3.99e-02	9.32e-01	8.06e-01	3.90e-01
RSK activation	7	3.22e-01	3.89e-01	0.586	-3.27e-01	-1.10e-01	1.12e-01	-1.13e-02	-3.87e-01	0.248000	1.35e-01	6.13e-01	6.07e-01	9.59e-01	7.62e-02	2.55e-01
Triglyceride catabolism	15	4.39e-02	7.77e-02	0.586	-2.51e-01	3.01e-02	3.34e-01	3.68e-02	-1.30e-01	0.387000	9.25e-02	8.40e-01	2.52e-02	8.05e-01	3.84e-01	9.52e-03
Diseases of hemostasis	13	4.15e-02	7.45e-02	0.586	1.99e-01	-2.62e-01	2.07e-01	-1.26e-01	-4.08e-01	0.100000	2.15e-01	1.02e-01	1.96e-01	4.31e-01	1.09e-02	5.31e-01
Synthesis of PIPs at the Golgi membrane	16	9.60e-04	2.89e-03	0.586	-3.17e-01	2.22e-01	-1.35e-01	1.77e-01	3.10e-01	-0.218000	2.79e-02	1.25e-01	3.51e-01	2.21e-01	3.19e-02	1.31e-01
BBSome-mediated cargo-targeting to cilium	22	8.83e-04	2.68e-03	0.585	-2.51e-01	-2.25e-01	-3.48e-01	-3.42e-03	3.14e-01	0.095700	4.14e-02	6.79e-02	4.72e-03	9.78e-01	1.07e-02	4.37e-01
MECP2 regulates neuronal receptors and channels	13	1.27e-01	1.85e-01	0.585	-8.25e-03	2.79e-01	2.53e-01	1.88e-01	1.56e-01	0.376000	9.59e-01	8.17e-02	1.15e-01	2.42e-01	3.31e-01	1.89e-02
Calnexin/calreticulin cycle	26	1.23e-04	4.75e-04	0.585	-4.47e-01	-2.41e-01	6.49e-02	7.52e-02	-1.92e-01	0.193000	8.07e-05	3.31e-02	5.67e-01	5.07e-01	8.94e-02	8.79e-02
Long-term potentiation	14	8.02e-02	1.28e-01	0.584	1.62e-01	1.78e-01	-2.54e-01	-2.74e-02	3.85e-01	-0.263000	2.93e-01	2.50e-01	9.96e-02	8.59e-01	1.25e-02	8.82e-02
AKT phosphorylates targets in the nucleus	9	1.20e-01	1.77e-01	0.584	-1.50e-03	1.42e-01	-9.53e-02	1.34e-01	3.11e-01	-0.444000	9.94e-01	4.62e-01	6.20e-01	4.86e-01	1.06e-01	2.11e-02
GABA synthesis, release, reuptake and degradation	11	1.86e-01	2.51e-01	0.584	1.63e-01	1.12e-01	5.66e-02	3.17e-01	4.44e-01	0.029400	3.50e-01	5.21e-01	7.45e-01	6.88e-02	1.08e-02	8.66e-01
STAT5 Activation	7	2.76e-02	5.31e-02	0.583	-3.67e-01	1.34e-01	3.60e-01	2.25e-01	7.79e-03	0.084400	9.25e-02	5.38e-01	9.88e-02	3.04e-01	9.72e-01	6.99e-01
Vpr-mediated nuclear import of PICs	34	2.53e-05	1.13e-04	0.583	-1.48e-01	-5.50e-02	-3.14e-01	3.50e-01	2.35e-01	-0.197000	1.36e-01	5.79e-01	1.54e-03	4.18e-04	1.75e-02	4.65e-02
Sperm Motility And Taxes	6	1.74e-01	2.38e-01	0.583	2.71e-01	-1.66e-01	-2.61e-02	1.74e-01	4.52e-01	-0.061500	2.50e-01	4.81e-01	9.12e-01	4.61e-01	5.53e-02	7.94e-01
IkBA variant leads to EDA-ID	7	1.31e-01	1.89e-01	0.583	1.01e-01	3.73e-01	1.64e-01	2.69e-01	1.63e-02	-0.302000	6.45e-01	8.77e-02	4.52e-01	2.18e-01	9.40e-01	1.67e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	8.59e-08	5.61e-07	0.582	-6.79e-02	2.82e-01	2.75e-01	2.71e-01	1.75e-02	0.324000	4.36e-01	1.22e-03	1.57e-03	1.85e-03	8.41e-01	1.97e-04
Post-chaperonin tubulin folding pathway	18	1.46e-02	3.10e-02	0.582	2.59e-03	-3.94e-01	1.86e-01	-5.23e-02	-3.43e-01	0.169000	9.85e-01	3.84e-03	1.72e-01	7.01e-01	1.18e-02	2.15e-01
Meiotic recombination	36	3.65e-05	1.59e-04	0.581	-1.76e-01	-4.62e-01	-3.05e-02	3.16e-02	-2.16e-01	0.210000	6.81e-02	1.61e-06	7.51e-01	7.43e-01	2.46e-02	2.93e-02
RHO GTPases Activate NADPH Oxidases	21	2.10e-02	4.17e-02	0.580	-1.25e-01	1.16e-01	3.37e-01	-1.30e-01	-4.72e-02	0.418000	3.21e-01	3.59e-01	7.58e-03	3.02e-01	7.08e-01	9.08e-04
Interleukin-2 family signaling	38	8.24e-05	3.29e-04	0.580	6.86e-02	3.43e-01	2.26e-01	2.79e-01	1.47e-01	0.252000	4.64e-01	2.55e-04	1.57e-02	2.92e-03	1.18e-01	7.22e-03
RHO GTPases activate KTN1	11	2.06e-01	2.72e-01	0.580	4.15e-02	6.95e-02	4.48e-01	1.66e-01	-8.26e-02	0.307000	8.12e-01	6.90e-01	1.01e-02	3.41e-01	6.35e-01	7.75e-02
Mitochondrial Fatty Acid Beta-Oxidation	36	1.17e-05	5.51e-05	0.579	-1.59e-01	-4.35e-01	-3.22e-01	-7.23e-03	1.29e-01	-0.005050	9.86e-02	6.18e-06	8.12e-04	9.40e-01	1.79e-01	9.58e-01
DNA Replication Pre-Initiation	103	9.94e-18	1.66e-16	0.579	-1.77e-01	-4.83e-01	-5.87e-02	4.80e-02	-1.42e-01	0.213000	1.96e-03	2.43e-17	3.04e-01	4.00e-01	1.30e-02	1.90e-04
Synthesis of pyrophosphates in the cytosol	8	6.48e-02	1.08e-01	0.578	-4.51e-01	-5.15e-02	-1.47e-01	2.93e-01	1.31e-01	0.055200	2.70e-02	8.01e-01	4.71e-01	1.51e-01	5.22e-01	7.87e-01
Cellular response to hypoxia	59	1.05e-09	9.06e-09	0.577	-2.22e-01	-4.06e-01	1.12e-01	2.52e-02	-1.32e-01	0.297000	3.19e-03	6.78e-08	1.38e-01	7.38e-01	7.97e-02	7.88e-05
VLDLR internalisation and degradation	15	7.95e-03	1.85e-02	0.577	-1.80e-01	-4.42e-01	-6.09e-02	2.69e-01	-1.52e-01	-0.069900	2.26e-01	3.04e-03	6.83e-01	7.08e-02	3.07e-01	6.39e-01
Mitochondrial tRNA aminoacylation	21	3.53e-03	9.23e-03	0.576	-8.89e-03	-4.30e-01	-2.87e-01	2.19e-01	1.13e-01	-0.060600	9.44e-01	6.40e-04	2.26e-02	8.27e-02	3.71e-01	6.31e-01
Pausing and recovery of Tat-mediated HIV elongation	30	3.69e-05	1.60e-04	0.576	2.45e-03	-4.00e-01	-2.01e-01	3.54e-01	-4.30e-02	-0.063000	9.81e-01	1.48e-04	5.68e-02	7.91e-04	6.83e-01	5.50e-01
Tat-mediated HIV elongation arrest and recovery	30	3.69e-05	1.60e-04	0.576	2.45e-03	-4.00e-01	-2.01e-01	3.54e-01	-4.30e-02	-0.063000	9.81e-01	1.48e-04	5.68e-02	7.91e-04	6.83e-01	5.50e-01
Interferon alpha/beta signaling	63	3.87e-15	5.54e-14	0.575	-3.94e-02	-1.58e-01	-1.28e-01	2.71e-01	1.53e-01	0.437000	5.89e-01	3.02e-02	7.99e-02	1.96e-04	3.60e-02	1.88e-09
Formation of the nephric duct	8	4.39e-01	5.02e-01	0.575	1.01e-01	6.16e-03	4.10e-01	-1.49e-03	-4.45e-02	0.388000	6.22e-01	9.76e-01	4.45e-02	9.94e-01	8.28e-01	5.76e-02
Caspase activation via Dependence Receptors in the absence of ligand	9	3.29e-01	3.96e-01	0.574	8.39e-02	-3.09e-02	3.75e-01	1.62e-01	9.51e-03	0.393000	6.63e-01	8.72e-01	5.13e-02	4.01e-01	9.61e-01	4.10e-02
CHL1 interactions	8	4.60e-01	5.21e-01	0.574	1.42e-01	-5.89e-02	3.82e-01	-7.06e-02	-2.53e-01	0.302000	4.87e-01	7.73e-01	6.16e-02	7.30e-01	2.15e-01	1.39e-01
Regulation of PTEN stability and activity	55	8.49e-08	5.56e-07	0.574	-2.27e-01	-4.04e-01	7.93e-02	-4.32e-02	-1.74e-01	0.276000	3.63e-03	2.21e-07	3.09e-01	5.80e-01	2.55e-02	3.90e-04
Formation of the beta-catenin:TCF transactivating complex	44	6.45e-06	3.21e-05	0.573	1.68e-01	-2.40e-02	3.56e-01	2.89e-01	-7.76e-02	0.289000	5.45e-02	7.83e-01	4.31e-05	9.10e-04	3.73e-01	8.96e-04
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	2.50e-01	3.20e-01	0.573	2.40e-02	2.29e-01	3.56e-01	3.69e-01	-9.59e-02	-0.061500	9.26e-01	3.76e-01	1.69e-01	1.53e-01	7.10e-01	8.12e-01
Sodium/Calcium exchangers	9	3.50e-01	4.16e-01	0.573	-3.44e-01	-2.28e-01	2.14e-01	-1.84e-01	-2.33e-01	0.157000	7.37e-02	2.36e-01	2.67e-01	3.39e-01	2.27e-01	4.15e-01
Heme degradation	10	7.51e-03	1.76e-02	0.573	1.81e-01	-3.17e-01	3.72e-01	1.46e-01	-1.72e-01	-0.077800	3.22e-01	8.23e-02	4.19e-02	4.23e-01	3.45e-01	6.70e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	2.37e-01	3.06e-01	0.571	-3.15e-01	-2.70e-01	7.37e-02	-1.11e-01	-3.70e-01	-0.013600	7.08e-02	1.20e-01	6.72e-01	5.25e-01	3.38e-02	9.38e-01
Synthesis of Ketone Bodies	6	3.68e-01	4.34e-01	0.571	-7.30e-02	-4.75e-01	-1.24e-01	8.40e-02	-5.73e-02	0.265000	7.57e-01	4.40e-02	6.00e-01	7.22e-01	8.08e-01	2.61e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	9.95e-04	2.98e-03	0.571	2.15e-03	-2.71e-01	2.17e-01	1.88e-01	-1.55e-01	0.382000	9.85e-01	1.89e-02	5.98e-02	1.04e-01	1.79e-01	9.46e-04
Dectin-1 mediated noncanonical NF-kB signaling	47	5.89e-08	3.97e-07	0.571	-2.10e-01	-4.53e-01	9.45e-03	3.46e-02	-6.91e-02	0.265000	1.29e-02	7.44e-08	9.11e-01	6.82e-01	4.12e-01	1.66e-03
Erythrocytes take up carbon dioxide and release oxygen	11	2.46e-01	3.15e-01	0.571	9.79e-02	1.93e-01	4.06e-01	1.60e-03	-2.79e-01	0.192000	5.74e-01	2.69e-01	1.97e-02	9.93e-01	1.10e-01	2.70e-01
O2/CO2 exchange in erythrocytes	11	2.46e-01	3.15e-01	0.571	9.79e-02	1.93e-01	4.06e-01	1.60e-03	-2.79e-01	0.192000	5.74e-01	2.69e-01	1.97e-02	9.93e-01	1.10e-01	2.70e-01
HSF1-dependent transactivation	28	1.32e-04	5.07e-04	0.571	2.43e-01	-3.19e-02	1.79e-01	4.49e-01	1.76e-01	-0.023700	2.58e-02	7.70e-01	1.01e-01	3.86e-05	1.07e-01	8.28e-01
Transcriptional regulation of granulopoiesis	44	1.29e-05	6.02e-05	0.570	2.16e-02	-1.24e-01	3.11e-01	1.23e-01	-2.30e-01	0.380000	8.04e-01	1.54e-01	3.55e-04	1.57e-01	8.28e-03	1.30e-05
Nephrin family interactions	19	4.10e-02	7.40e-02	0.570	1.04e-01	2.41e-01	3.32e-01	1.50e-01	-1.11e-01	0.334000	4.34e-01	6.93e-02	1.24e-02	2.56e-01	4.03e-01	1.17e-02
ER-Phagosome pathway	74	3.78e-10	3.48e-09	0.569	-3.05e-01	-3.62e-01	-2.67e-02	-2.62e-02	-1.51e-01	0.276000	5.80e-06	7.03e-08	6.91e-01	6.97e-01	2.46e-02	4.15e-05
Attenuation phase	22	1.89e-03	5.30e-03	0.569	2.03e-01	-2.47e-02	2.88e-01	3.98e-01	1.53e-01	0.134000	1.00e-01	8.41e-01	1.96e-02	1.23e-03	2.15e-01	2.78e-01
Signaling by cytosolic FGFR1 fusion mutants	18	7.11e-04	2.21e-03	0.569	-3.27e-01	2.00e-01	2.19e-01	1.85e-01	2.43e-02	0.307000	1.62e-02	1.42e-01	1.07e-01	1.75e-01	8.58e-01	2.43e-02
Nef mediated downregulation of MHC class I complex cell surface expression	10	7.69e-02	1.23e-01	0.569	-3.44e-01	-2.49e-01	-3.39e-02	1.52e-01	-3.27e-01	0.112000	5.96e-02	1.72e-01	8.53e-01	4.07e-01	7.38e-02	5.41e-01
LGI-ADAM interactions	9	4.61e-01	5.22e-01	0.568	1.40e-01	2.65e-01	-2.93e-02	2.66e-01	3.70e-01	-0.157000	4.66e-01	1.69e-01	8.79e-01	1.67e-01	5.45e-02	4.16e-01
Sema4D mediated inhibition of cell attachment and migration	7	5.68e-02	9.72e-02	0.568	-1.49e-01	-3.78e-01	1.78e-01	1.06e-01	-2.22e-01	-0.255000	4.94e-01	8.31e-02	4.15e-01	6.29e-01	3.10e-01	2.42e-01
Ketone body metabolism	8	2.70e-01	3.39e-01	0.567	-1.10e-01	-4.77e-01	-7.97e-02	1.08e-01	-1.25e-01	0.222000	5.90e-01	1.96e-02	6.96e-01	5.98e-01	5.41e-01	2.77e-01
Base Excision Repair	56	7.69e-10	6.86e-09	0.567	-3.83e-02	-4.62e-01	-2.24e-01	2.25e-01	7.12e-02	-0.000855	6.20e-01	2.17e-09	3.72e-03	3.54e-03	3.57e-01	9.91e-01
Activation of NF-kappaB in B cells	54	1.08e-07	7.01e-07	0.566	-2.47e-01	-3.84e-01	9.45e-02	-1.40e-02	-1.51e-01	0.283000	1.69e-03	1.03e-06	2.30e-01	8.59e-01	5.49e-02	3.18e-04
Prefoldin mediated transfer of substrate to CCT/TriC	25	4.04e-04	1.34e-03	0.566	-1.28e-01	-4.67e-01	7.63e-02	-1.28e-02	-1.17e-01	0.257000	2.69e-01	5.27e-05	5.09e-01	9.12e-01	3.11e-01	2.61e-02
Cargo concentration in the ER	31	4.06e-05	1.75e-04	0.566	-3.37e-01	1.15e-02	2.74e-01	4.89e-02	-3.73e-02	0.357000	1.17e-03	9.12e-01	8.28e-03	6.37e-01	7.19e-01	5.76e-04
Vitamin C (ascorbate) metabolism	8	4.66e-01	5.25e-01	0.566	1.82e-01	3.23e-01	3.73e-01	1.06e-01	1.61e-01	0.081400	3.73e-01	1.13e-01	6.81e-02	6.04e-01	4.31e-01	6.90e-01
Sulfur amino acid metabolism	22	2.40e-02	4.69e-02	0.565	-1.28e-01	-3.31e-01	-3.37e-01	-4.05e-02	1.03e-01	-0.259000	2.97e-01	7.23e-03	6.18e-03	7.42e-01	4.03e-01	3.53e-02
Nuclear events stimulated by ALK signaling in cancer	33	2.15e-03	5.95e-03	0.565	1.29e-01	1.90e-01	1.74e-01	3.23e-01	2.19e-01	0.289000	2.01e-01	5.88e-02	8.44e-02	1.30e-03	2.98e-02	4.05e-03
Nef Mediated CD4 Down-regulation	9	4.59e-02	8.04e-02	0.564	-1.07e-01	-3.72e-01	4.77e-02	3.94e-01	-8.72e-02	-0.058300	5.78e-01	5.36e-02	8.04e-01	4.06e-02	6.50e-01	7.62e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	2.79e-01	3.48e-01	0.564	-4.23e-03	1.64e-02	-1.43e-01	6.64e-02	-2.83e-02	-0.540000	9.85e-01	9.40e-01	5.11e-01	7.61e-01	8.97e-01	1.34e-02
Keratan sulfate biosynthesis	19	4.07e-02	7.38e-02	0.563	1.00e-01	9.24e-02	3.40e-01	2.95e-01	4.13e-02	0.306000	4.50e-01	4.86e-01	1.03e-02	2.59e-02	7.55e-01	2.09e-02
Molybdenum cofactor biosynthesis	6	4.67e-01	5.26e-01	0.563	-1.74e-01	-1.19e-01	-2.07e-01	2.62e-01	3.97e-01	0.058300	4.62e-01	6.13e-01	3.80e-01	2.66e-01	9.25e-02	8.05e-01
Nef Mediated CD8 Down-regulation	7	2.07e-01	2.73e-01	0.562	5.08e-02	-2.85e-01	1.85e-01	3.76e-01	-2.22e-01	0.086100	8.16e-01	1.91e-01	3.97e-01	8.49e-02	3.08e-01	6.93e-01
Mitochondrial Uncoupling	6	5.65e-01	6.17e-01	0.562	2.16e-02	-1.19e-01	-3.14e-01	3.35e-02	3.78e-01	-0.243000	9.27e-01	6.13e-01	1.83e-01	8.87e-01	1.09e-01	3.03e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	8.11e-02	1.29e-01	0.562	-2.50e-01	-4.01e-01	-1.66e-01	8.76e-02	-6.44e-02	0.232000	1.19e-01	1.24e-02	3.01e-01	5.85e-01	6.88e-01	1.48e-01
Uptake and function of anthrax toxins	10	1.42e-01	2.02e-01	0.562	-2.74e-01	-1.85e-03	3.42e-01	8.57e-02	-1.55e-01	0.304000	1.34e-01	9.92e-01	6.10e-02	6.39e-01	3.97e-01	9.63e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	1.29e-03	3.76e-03	0.561	-2.58e-01	7.28e-03	4.31e-01	1.35e-01	-7.96e-02	0.197000	7.42e-02	9.60e-01	2.86e-03	3.51e-01	5.81e-01	1.73e-01
Glycosphingolipid catabolism	31	6.02e-03	1.46e-02	0.561	-3.63e-01	-3.27e-01	-1.32e-01	-1.85e-01	-1.24e-01	-0.093500	4.73e-04	1.61e-03	2.05e-01	7.42e-02	2.31e-01	3.68e-01
MET receptor recycling	9	1.09e-01	1.64e-01	0.561	-2.29e-01	1.26e-01	1.91e-01	-6.24e-02	-4.22e-01	0.166000	2.33e-01	5.14e-01	3.20e-01	7.46e-01	2.85e-02	3.87e-01
Reversible hydration of carbon dioxide	8	1.98e-01	2.64e-01	0.559	3.26e-01	1.69e-01	1.95e-01	9.25e-02	-2.15e-01	-0.292000	1.11e-01	4.07e-01	3.40e-01	6.50e-01	2.91e-01	1.53e-01
Erythropoietin activates RAS	13	3.00e-02	5.70e-02	0.559	-2.99e-01	1.67e-01	3.09e-01	9.06e-02	-5.07e-02	0.298000	6.23e-02	2.97e-01	5.35e-02	5.72e-01	7.52e-01	6.30e-02
Switching of origins to a post-replicative state	79	6.97e-14	8.98e-13	0.559	-1.43e-01	-4.71e-01	-3.56e-02	5.23e-02	-8.07e-02	0.244000	2.83e-02	4.58e-13	5.84e-01	4.22e-01	2.15e-01	1.78e-04
Linoleic acid (LA) metabolism	7	3.02e-01	3.71e-01	0.558	-7.74e-02	2.31e-01	4.20e-01	-5.77e-02	1.74e-01	0.205000	7.23e-01	2.91e-01	5.42e-02	7.91e-01	4.26e-01	3.48e-01
Regulation of RUNX2 expression and activity	54	6.89e-08	4.57e-07	0.556	-2.18e-01	-4.28e-01	5.23e-04	-2.50e-02	-1.05e-01	0.259000	5.64e-03	5.27e-08	9.95e-01	7.51e-01	1.82e-01	9.76e-04
InlA-mediated entry of Listeria monocytogenes into host cells	9	5.15e-01	5.71e-01	0.556	-2.26e-01	-4.04e-01	-2.79e-01	-5.55e-02	-7.08e-02	-0.091700	2.40e-01	3.56e-02	1.47e-01	7.73e-01	7.13e-01	6.34e-01
Creatine metabolism	6	3.27e-01	3.94e-01	0.556	3.02e-01	7.34e-02	1.18e-01	7.25e-02	4.33e-01	0.079900	2.01e-01	7.55e-01	6.17e-01	7.58e-01	6.64e-02	7.35e-01
Activated NTRK2 signals through FRS2 and FRS3	8	3.31e-01	3.98e-01	0.556	-2.27e-01	1.39e-01	3.32e-01	4.71e-02	-1.40e-01	0.326000	2.66e-01	4.97e-01	1.04e-01	8.18e-01	4.93e-01	1.11e-01
Termination of translesion DNA synthesis	32	8.28e-05	3.30e-04	0.554	-6.99e-02	-4.03e-01	-3.30e-01	1.29e-01	1.10e-01	0.040900	4.93e-01	7.82e-05	1.22e-03	2.06e-01	2.82e-01	6.89e-01
EPHB-mediated forward signaling	38	2.80e-05	1.24e-04	0.554	-2.74e-01	-1.06e-01	2.15e-01	7.90e-02	-1.32e-01	0.389000	3.44e-03	2.58e-01	2.20e-02	4.00e-01	1.60e-01	3.39e-05
Other interleukin signaling	18	1.16e-01	1.72e-01	0.554	1.59e-01	2.51e-01	9.46e-02	3.58e-01	2.56e-01	0.124000	2.43e-01	6.51e-02	4.87e-01	8.48e-03	5.99e-02	3.61e-01
Regulation of TLR by endogenous ligand	15	1.25e-02	2.73e-02	0.554	-3.96e-01	1.27e-01	6.27e-02	-1.22e-01	2.26e-01	0.253000	7.95e-03	3.95e-01	6.74e-01	4.12e-01	1.30e-01	9.03e-02
Generation of second messenger molecules	38	2.83e-04	9.89e-04	0.553	1.37e-01	6.19e-02	-2.86e-01	2.47e-01	3.74e-01	-0.029800	1.44e-01	5.09e-01	2.32e-03	8.48e-03	6.48e-05	7.50e-01
Gap junction assembly	16	4.34e-02	7.69e-02	0.553	1.64e-01	-1.40e-01	3.93e-01	-2.95e-02	-2.24e-01	0.231000	2.56e-01	3.32e-01	6.45e-03	8.38e-01	1.20e-01	1.10e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	3.05e-05	1.34e-04	0.552	-1.77e-01	-7.57e-03	-2.83e-01	3.54e-01	2.02e-01	-0.165000	8.29e-02	9.41e-01	5.54e-03	5.33e-04	4.76e-02	1.06e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	1.06e-01	1.60e-01	0.552	-2.25e-01	-3.69e-01	-1.07e-01	8.17e-02	-9.14e-02	0.302000	1.77e-01	2.70e-02	5.22e-01	6.24e-01	5.84e-01	6.98e-02
Interleukin-10 signaling	35	1.66e-08	1.25e-07	0.551	2.29e-02	3.34e-01	3.85e-01	-5.11e-02	1.37e-01	-0.149000	8.15e-01	6.31e-04	8.10e-05	6.01e-01	1.60e-01	1.26e-01
APC-Cdc20 mediated degradation of Nek2A	26	2.20e-03	6.04e-03	0.550	-1.29e-01	-4.50e-01	-1.84e-01	-6.63e-02	-1.67e-01	0.136000	2.56e-01	7.20e-05	1.05e-01	5.59e-01	1.41e-01	2.31e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	1.12e-01	1.67e-01	0.550	-5.47e-02	-4.13e-01	-2.87e-01	2.39e-02	1.89e-01	-0.103000	7.54e-01	1.77e-02	9.90e-02	8.91e-01	2.78e-01	5.54e-01
PRC2 methylates histones and DNA	27	9.63e-04	2.89e-03	0.550	-1.37e-01	-4.70e-01	3.47e-02	3.87e-02	-1.87e-01	0.160000	2.17e-01	2.37e-05	7.55e-01	7.28e-01	9.20e-02	1.51e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.12e-02	1.03e-01	0.550	-2.99e-01	1.98e-01	2.81e-01	6.43e-02	-1.30e-01	0.274000	8.64e-02	2.57e-01	1.07e-01	7.12e-01	4.55e-01	1.16e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.79e-03	5.06e-03	0.550	-3.21e-01	-2.88e-01	3.29e-02	-8.22e-03	-1.84e-01	0.286000	2.32e-03	6.39e-03	7.55e-01	9.38e-01	8.15e-02	6.66e-03
Attachment and Entry 9694614	13	1.01e-01	1.54e-01	0.550	8.55e-02	1.21e-01	3.59e-01	3.18e-01	1.14e-01	0.193000	5.93e-01	4.50e-01	2.50e-02	4.69e-02	4.78e-01	2.28e-01
Regulation of signaling by CBL	22	3.95e-04	1.32e-03	0.549	-1.62e-01	2.59e-01	2.11e-01	2.63e-01	-1.56e-04	0.307000	1.87e-01	3.52e-02	8.71e-02	3.27e-02	9.99e-01	1.28e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	6.75e-02	1.11e-01	0.549	-2.22e-01	-3.09e-01	-3.82e-01	4.85e-02	9.28e-02	-0.019800	1.14e-01	2.76e-02	6.45e-03	7.29e-01	5.08e-01	8.88e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	6.05e-02	1.02e-01	0.549	-2.10e-01	-3.63e-01	-3.48e-01	-3.47e-02	4.78e-02	0.015900	1.34e-01	9.48e-03	1.29e-02	8.04e-01	7.33e-01	9.10e-01
Endosomal/Vacuolar pathway	11	3.64e-01	4.31e-01	0.549	-2.95e-01	-3.37e-01	-3.12e-01	-4.97e-02	-2.07e-02	-0.016300	9.08e-02	5.27e-02	7.34e-02	7.75e-01	9.06e-01	9.25e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	5.83e-01	6.33e-01	0.548	-2.20e-01	-4.00e-01	4.47e-03	-1.09e-01	-2.73e-01	0.077800	2.81e-01	5.02e-02	9.83e-01	5.92e-01	1.82e-01	7.03e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	6.06e-06	3.03e-05	0.548	-8.04e-02	-2.32e-01	3.02e-01	-4.88e-04	-2.02e-01	0.329000	3.35e-01	5.48e-03	3.00e-04	9.95e-01	1.54e-02	7.82e-05
Formation of TC-NER Pre-Incision Complex	51	3.32e-06	1.75e-05	0.547	-2.33e-01	-3.99e-01	-2.81e-01	7.17e-02	-2.71e-02	0.038400	4.01e-03	8.24e-07	5.20e-04	3.76e-01	7.38e-01	6.35e-01
Recognition of DNA damage by PCNA-containing replication complex	30	4.80e-04	1.58e-03	0.547	-1.83e-01	-4.19e-01	-2.68e-01	8.15e-02	8.53e-02	0.066200	8.23e-02	7.06e-05	1.10e-02	4.40e-01	4.19e-01	5.30e-01
Kidney development	16	1.29e-01	1.87e-01	0.547	5.03e-02	-2.94e-02	3.92e-01	-1.62e-02	-1.36e-01	0.351000	7.28e-01	8.39e-01	6.63e-03	9.11e-01	3.45e-01	1.51e-02
Cell surface interactions at the vascular wall	168	6.03e-28	1.45e-26	0.546	-6.85e-02	-2.55e-01	2.02e-01	2.00e-01	-2.48e-01	0.294000	1.26e-01	1.14e-08	6.39e-06	7.82e-06	2.75e-08	4.87e-11
Pre-NOTCH Processing in Golgi	18	2.11e-03	5.86e-03	0.546	-7.35e-02	7.23e-02	2.84e-01	4.11e-01	-2.14e-03	0.195000	5.89e-01	5.95e-01	3.72e-02	2.54e-03	9.87e-01	1.52e-01
Formation of Incision Complex in GG-NER	43	2.83e-04	9.89e-04	0.545	-2.75e-01	-3.76e-01	-2.71e-01	-6.30e-02	-5.00e-02	0.011700	1.81e-03	1.96e-05	2.10e-03	4.75e-01	5.70e-01	8.95e-01
Kinesins	51	2.55e-06	1.37e-05	0.545	2.56e-01	-5.50e-02	3.47e-01	1.64e-01	-1.24e-01	0.257000	1.59e-03	4.97e-01	1.81e-05	4.25e-02	1.26e-01	1.50e-03
Fc epsilon receptor (FCERI) signaling	178	1.81e-27	4.19e-26	0.544	-1.07e-01	-2.53e-01	1.72e-01	1.45e-01	-2.40e-01	0.336000	1.42e-02	6.04e-09	7.88e-05	8.19e-04	3.14e-08	1.04e-14
G beta:gamma signalling through BTK	15	1.25e-01	1.82e-01	0.544	-1.72e-01	-1.43e-01	2.44e-01	3.85e-02	-2.22e-01	0.369000	2.48e-01	3.39e-01	1.02e-01	7.96e-01	1.37e-01	1.34e-02
Branched-chain amino acid catabolism	21	4.44e-02	7.84e-02	0.544	-3.29e-01	-3.21e-01	-2.86e-01	-4.65e-02	1.85e-03	0.022300	9.00e-03	1.09e-02	2.31e-02	7.12e-01	9.88e-01	8.60e-01
Asymmetric localization of PCP proteins	49	1.15e-06	6.48e-06	0.544	-2.33e-01	-4.22e-01	4.79e-02	2.05e-02	-1.48e-01	0.198000	4.71e-03	3.29e-07	5.62e-01	8.04e-01	7.34e-02	1.68e-02
RHOBTB1 GTPase cycle	23	1.65e-02	3.42e-02	0.543	-2.59e-01	-2.88e-01	1.07e-01	-9.24e-03	-1.85e-01	0.315000	3.13e-02	1.68e-02	3.73e-01	9.39e-01	1.25e-01	8.88e-03
HIV elongation arrest and recovery	32	5.86e-05	2.44e-04	0.542	-2.97e-03	-3.70e-01	-1.83e-01	3.44e-01	-5.62e-02	-0.044900	9.77e-01	2.93e-04	7.35e-02	7.57e-04	5.82e-01	6.60e-01
Pausing and recovery of HIV elongation	32	5.86e-05	2.44e-04	0.542	-2.97e-03	-3.70e-01	-1.83e-01	3.44e-01	-5.62e-02	-0.044900	9.77e-01	2.93e-04	7.35e-02	7.57e-04	5.82e-01	6.60e-01
Dual Incision in GG-NER	41	2.27e-05	1.02e-04	0.542	-1.54e-01	-4.18e-01	-2.81e-01	5.18e-02	1.11e-01	-0.038900	8.71e-02	3.68e-06	1.86e-03	5.66e-01	2.21e-01	6.66e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	4.30e-02	7.65e-02	0.542	-5.29e-04	3.39e-04	3.23e-01	2.43e-01	8.94e-02	0.350000	9.97e-01	9.98e-01	2.13e-02	8.29e-02	5.23e-01	1.25e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	4.30e-02	7.65e-02	0.542	-5.29e-04	3.39e-04	3.23e-01	2.43e-01	8.94e-02	0.350000	9.97e-01	9.98e-01	2.13e-02	8.29e-02	5.23e-01	1.25e-02
NPAS4 regulates expression of target genes	16	8.56e-03	1.96e-02	0.542	-2.90e-01	4.75e-02	3.32e-01	-1.94e-01	-2.41e-01	-0.032600	4.43e-02	7.42e-01	2.16e-02	1.78e-01	9.57e-02	8.21e-01
Glycerophospholipid catabolism	6	7.06e-01	7.43e-01	0.541	1.78e-01	1.67e-01	-1.67e-01	1.13e-01	4.28e-01	-0.098300	4.51e-01	4.78e-01	4.79e-01	6.30e-01	6.95e-02	6.77e-01
Metabolism of non-coding RNA	53	4.50e-06	2.30e-05	0.540	-9.78e-02	-2.71e-01	-3.31e-01	2.38e-01	1.35e-01	-0.155000	2.18e-01	6.49e-04	3.02e-05	2.70e-03	9.01e-02	5.14e-02
snRNP Assembly	53	4.50e-06	2.30e-05	0.540	-9.78e-02	-2.71e-01	-3.31e-01	2.38e-01	1.35e-01	-0.155000	2.18e-01	6.49e-04	3.02e-05	2.70e-03	9.01e-02	5.14e-02
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	6.80e-02	1.11e-01	0.539	-6.70e-02	1.93e-01	1.23e-01	1.40e-01	1.48e-01	-0.438000	7.59e-01	3.78e-01	5.73e-01	5.21e-01	4.97e-01	4.46e-02
Gastrin-CREB signalling pathway via PKC and MAPK	14	1.33e-01	1.91e-01	0.539	-2.01e-01	6.00e-02	3.25e-01	1.19e-02	-5.57e-02	0.370000	1.92e-01	6.98e-01	3.52e-02	9.39e-01	7.18e-01	1.64e-02
Beta-catenin phosphorylation cascade	17	1.00e-02	2.23e-02	0.539	-2.96e-01	1.02e-01	2.31e-01	6.53e-02	-1.97e-01	0.309000	3.46e-02	4.66e-01	9.93e-02	6.41e-01	1.59e-01	2.73e-02
Dectin-2 family	18	6.15e-02	1.03e-01	0.538	-1.06e-01	2.62e-01	2.90e-01	-1.33e-01	-8.08e-02	0.319000	4.36e-01	5.41e-02	3.31e-02	3.30e-01	5.53e-01	1.93e-02
APC truncation mutants have impaired AXIN binding	14	1.69e-02	3.48e-02	0.538	-2.96e-01	2.03e-01	1.82e-01	5.24e-02	-1.37e-01	0.326000	5.54e-02	1.89e-01	2.39e-01	7.34e-01	3.76e-01	3.45e-02
AXIN missense mutants destabilize the destruction complex	14	1.69e-02	3.48e-02	0.538	-2.96e-01	2.03e-01	1.82e-01	5.24e-02	-1.37e-01	0.326000	5.54e-02	1.89e-01	2.39e-01	7.34e-01	3.76e-01	3.45e-02
Signaling by AMER1 mutants	14	1.69e-02	3.48e-02	0.538	-2.96e-01	2.03e-01	1.82e-01	5.24e-02	-1.37e-01	0.326000	5.54e-02	1.89e-01	2.39e-01	7.34e-01	3.76e-01	3.45e-02
Signaling by APC mutants	14	1.69e-02	3.48e-02	0.538	-2.96e-01	2.03e-01	1.82e-01	5.24e-02	-1.37e-01	0.326000	5.54e-02	1.89e-01	2.39e-01	7.34e-01	3.76e-01	3.45e-02
Signaling by AXIN mutants	14	1.69e-02	3.48e-02	0.538	-2.96e-01	2.03e-01	1.82e-01	5.24e-02	-1.37e-01	0.326000	5.54e-02	1.89e-01	2.39e-01	7.34e-01	3.76e-01	3.45e-02
Truncations of AMER1 destabilize the destruction complex	14	1.69e-02	3.48e-02	0.538	-2.96e-01	2.03e-01	1.82e-01	5.24e-02	-1.37e-01	0.326000	5.54e-02	1.89e-01	2.39e-01	7.34e-01	3.76e-01	3.45e-02
ER Quality Control Compartment (ERQC)	21	9.00e-03	2.03e-02	0.538	-4.66e-01	-1.63e-01	1.86e-03	-3.48e-02	-1.44e-01	0.153000	2.16e-04	1.95e-01	9.88e-01	7.82e-01	2.53e-01	2.24e-01
Telomere Maintenance	78	6.01e-13	7.25e-12	0.537	-4.53e-02	-4.50e-01	-1.34e-01	2.30e-01	-8.09e-02	0.083500	4.89e-01	6.27e-12	4.13e-02	4.41e-04	2.17e-01	2.03e-01
Golgi Associated Vesicle Biogenesis	55	2.37e-07	1.46e-06	0.537	-3.76e-01	-2.15e-01	1.11e-01	-2.30e-03	-2.26e-01	0.194000	1.43e-06	5.92e-03	1.53e-01	9.76e-01	3.71e-03	1.29e-02
Metabolism of amino acids and derivatives	302	2.42e-40	1.03e-38	0.536	-1.83e-01	-4.38e-01	-2.35e-01	-7.20e-02	-2.30e-02	-0.017300	4.26e-08	2.23e-39	2.20e-12	3.14e-02	4.93e-01	6.04e-01
Signaling by activated point mutants of FGFR1	5	8.07e-01	8.38e-01	0.536	-9.55e-02	-1.80e-01	-3.69e-02	-3.02e-01	-3.22e-01	-0.222000	7.11e-01	4.85e-01	8.86e-01	2.42e-01	2.13e-01	3.90e-01
Signaling by FGFR4 in disease	11	1.61e-01	2.23e-01	0.536	-1.12e-01	3.76e-01	2.79e-01	3.82e-02	1.41e-02	0.230000	5.18e-01	3.06e-02	1.09e-01	8.26e-01	9.36e-01	1.86e-01
PERK regulates gene expression	30	2.04e-02	4.08e-02	0.535	-2.83e-01	-3.60e-01	-1.50e-01	-1.86e-01	-1.39e-01	0.003280	7.29e-03	6.34e-04	1.56e-01	7.84e-02	1.88e-01	9.75e-01
Acyl chain remodelling of PG	11	2.13e-01	2.80e-01	0.535	-2.57e-01	5.89e-02	2.79e-01	-2.93e-01	-3.18e-02	0.227000	1.40e-01	7.35e-01	1.09e-01	9.22e-02	8.55e-01	1.92e-01
RAS signaling downstream of NF1 loss-of-function variants	7	4.63e-01	5.23e-01	0.534	-1.98e-01	2.24e-01	3.04e-01	4.01e-02	-5.79e-02	0.314000	3.64e-01	3.04e-01	1.64e-01	8.54e-01	7.91e-01	1.50e-01
CTNNB1 S33 mutants aren’t phosphorylated	15	8.51e-03	1.95e-02	0.534	-3.35e-01	1.93e-01	1.86e-01	3.71e-02	-1.62e-01	0.271000	2.45e-02	1.95e-01	2.13e-01	8.03e-01	2.78e-01	6.91e-02
CTNNB1 S37 mutants aren’t phosphorylated	15	8.51e-03	1.95e-02	0.534	-3.35e-01	1.93e-01	1.86e-01	3.71e-02	-1.62e-01	0.271000	2.45e-02	1.95e-01	2.13e-01	8.03e-01	2.78e-01	6.91e-02
CTNNB1 S45 mutants aren’t phosphorylated	15	8.51e-03	1.95e-02	0.534	-3.35e-01	1.93e-01	1.86e-01	3.71e-02	-1.62e-01	0.271000	2.45e-02	1.95e-01	2.13e-01	8.03e-01	2.78e-01	6.91e-02
CTNNB1 T41 mutants aren’t phosphorylated	15	8.51e-03	1.95e-02	0.534	-3.35e-01	1.93e-01	1.86e-01	3.71e-02	-1.62e-01	0.271000	2.45e-02	1.95e-01	2.13e-01	8.03e-01	2.78e-01	6.91e-02
Signaling by CTNNB1 phospho-site mutants	15	8.51e-03	1.95e-02	0.534	-3.35e-01	1.93e-01	1.86e-01	3.71e-02	-1.62e-01	0.271000	2.45e-02	1.95e-01	2.13e-01	8.03e-01	2.78e-01	6.91e-02
Signaling by GSK3beta mutants	15	8.51e-03	1.95e-02	0.534	-3.35e-01	1.93e-01	1.86e-01	3.71e-02	-1.62e-01	0.271000	2.45e-02	1.95e-01	2.13e-01	8.03e-01	2.78e-01	6.91e-02
Gap junction degradation	11	1.13e-02	2.48e-02	0.534	-2.84e-01	-3.83e-02	2.08e-01	3.51e-01	-1.21e-01	0.148000	1.03e-01	8.26e-01	2.32e-01	4.38e-02	4.89e-01	3.94e-01
PECAM1 interactions	12	3.95e-02	7.20e-02	0.534	-2.39e-01	1.91e-01	1.83e-01	2.36e-01	1.64e-02	0.319000	1.51e-01	2.52e-01	2.74e-01	1.56e-01	9.22e-01	5.57e-02
Retrograde neurotrophin signalling	12	1.24e-02	2.69e-02	0.534	-2.64e-01	-2.97e-01	9.27e-02	3.21e-01	-1.21e-01	0.024500	1.14e-01	7.44e-02	5.78e-01	5.41e-02	4.68e-01	8.83e-01
DARPP-32 events	22	1.56e-02	3.29e-02	0.534	-2.24e-01	-8.15e-02	2.59e-01	6.60e-02	-1.84e-01	0.350000	6.84e-02	5.08e-01	3.58e-02	5.92e-01	1.35e-01	4.47e-03
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	9.69e-02	1.49e-01	0.532	2.93e-01	3.12e-01	1.13e-02	1.87e-01	-2.18e-01	0.132000	1.79e-01	1.53e-01	9.59e-01	3.92e-01	3.18e-01	5.46e-01
Voltage gated Potassium channels	25	9.89e-03	2.20e-02	0.532	3.76e-01	2.78e-01	2.40e-01	-2.22e-02	5.25e-02	-0.058000	1.13e-03	1.63e-02	3.77e-02	8.48e-01	6.49e-01	6.16e-01
Synthesis of PG	8	2.09e-01	2.75e-01	0.532	-1.47e-01	8.06e-02	-9.92e-02	4.19e-01	2.49e-01	-0.087200	4.72e-01	6.93e-01	6.27e-01	4.03e-02	2.24e-01	6.69e-01
Translesion Synthesis by POLH	18	2.67e-02	5.17e-02	0.532	-8.77e-02	-3.54e-01	-3.77e-01	8.07e-02	2.30e-02	0.017500	5.20e-01	9.26e-03	5.64e-03	5.53e-01	8.66e-01	8.98e-01
E2F-enabled inhibition of pre-replication complex formation	9	2.82e-01	3.51e-01	0.531	-1.33e-01	-2.83e-01	5.88e-02	6.95e-02	-7.90e-02	0.413000	4.91e-01	1.42e-01	7.60e-01	7.18e-01	6.81e-01	3.20e-02
VEGF binds to VEGFR leading to receptor dimerization	5	4.23e-01	4.88e-01	0.531	4.48e-02	-4.16e-01	2.23e-01	-8.02e-02	-2.24e-01	-0.021400	8.62e-01	1.07e-01	3.87e-01	7.56e-01	3.86e-01	9.34e-01
VEGF ligand-receptor interactions	5	4.23e-01	4.88e-01	0.531	4.48e-02	-4.16e-01	2.23e-01	-8.02e-02	-2.24e-01	-0.021400	8.62e-01	1.07e-01	3.87e-01	7.56e-01	3.86e-01	9.34e-01
Negative regulation of FGFR3 signaling	21	5.97e-02	1.01e-01	0.531	-3.29e-01	-2.40e-01	7.55e-02	-8.88e-02	-2.83e-01	0.151000	9.09e-03	5.74e-02	5.49e-01	4.81e-01	2.48e-02	2.31e-01
Infection with Mycobacterium tuberculosis	26	5.41e-04	1.74e-03	0.531	-2.59e-01	-2.73e-01	6.77e-02	1.72e-01	-2.85e-01	0.156000	2.23e-02	1.59e-02	5.50e-01	1.29e-01	1.18e-02	1.69e-01
RHO GTPases Activate ROCKs	18	1.11e-01	1.66e-01	0.530	-1.40e-01	-1.49e-02	2.85e-01	-4.74e-02	-2.70e-01	0.324000	3.03e-01	9.13e-01	3.65e-02	7.28e-01	4.76e-02	1.73e-02
Phase 3 - rapid repolarisation	6	4.30e-01	4.92e-01	0.529	-3.33e-01	6.37e-02	-4.32e-02	-1.25e-01	2.48e-01	0.293000	1.58e-01	7.87e-01	8.54e-01	5.96e-01	2.92e-01	2.15e-01
Formation of the Early Elongation Complex	33	5.15e-04	1.67e-03	0.529	-1.30e-01	-4.32e-01	-2.23e-01	1.61e-01	-1.68e-02	-0.024800	1.96e-01	1.76e-05	2.68e-02	1.10e-01	8.67e-01	8.05e-01
Formation of the HIV-1 Early Elongation Complex	33	5.15e-04	1.67e-03	0.529	-1.30e-01	-4.32e-01	-2.23e-01	1.61e-01	-1.68e-02	-0.024800	1.96e-01	1.76e-05	2.68e-02	1.10e-01	8.67e-01	8.05e-01
Budding and maturation of HIV virion	26	2.32e-03	6.31e-03	0.529	-1.54e-01	-4.17e-01	-3.25e-03	1.07e-01	-1.33e-01	0.230000	1.75e-01	2.30e-04	9.77e-01	3.44e-01	2.40e-01	4.27e-02
Metabolism of RNA	716	7.41e-97	4.74e-94	0.528	-1.37e-01	-4.19e-01	-2.73e-01	9.38e-02	-3.06e-02	-0.028100	4.81e-10	9.31e-82	1.20e-35	1.94e-05	1.64e-01	2.00e-01
DNA Replication	128	1.07e-20	2.00e-19	0.528	-1.27e-01	-4.57e-01	-5.46e-02	6.62e-02	-7.73e-02	0.202000	1.29e-02	4.32e-19	2.86e-01	1.96e-01	1.31e-01	7.77e-05
tRNA modification in the nucleus and cytosol	43	1.60e-05	7.36e-05	0.528	-1.97e-02	-3.99e-01	-2.98e-01	3.48e-02	9.51e-02	-0.141000	8.23e-01	5.98e-06	7.18e-04	6.93e-01	2.81e-01	1.09e-01
Induction of Cell-Cell Fusion	8	2.84e-01	3.53e-01	0.528	-1.52e-01	1.26e-02	4.32e-01	-2.35e-02	-4.54e-03	0.261000	4.56e-01	9.51e-01	3.43e-02	9.08e-01	9.82e-01	2.02e-01
Adherens junctions interactions	36	6.19e-04	1.96e-03	0.527	4.01e-02	3.93e-01	2.17e-01	1.38e-01	2.23e-01	0.077100	6.77e-01	4.58e-05	2.43e-02	1.51e-01	2.09e-02	4.23e-01
tRNA processing	128	4.26e-14	5.56e-13	0.526	-1.13e-01	-3.76e-01	-2.96e-01	8.83e-02	-4.39e-02	-0.159000	2.67e-02	2.03e-13	7.16e-09	8.46e-02	3.92e-01	1.93e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.80e-01	3.49e-01	0.526	-1.46e-01	-3.88e-01	-2.93e-01	-5.34e-02	8.90e-02	-0.088000	4.02e-01	2.57e-02	9.26e-02	7.59e-01	6.09e-01	6.13e-01
B-WICH complex positively regulates rRNA expression	45	7.04e-05	2.85e-04	0.525	-1.51e-01	-4.19e-01	-1.31e-02	-3.03e-02	-2.74e-01	-0.021000	7.93e-02	1.13e-06	8.79e-01	7.25e-01	1.48e-03	8.07e-01
Hydrolysis of LPC	8	1.66e-01	2.29e-01	0.525	-2.26e-01	-5.90e-02	3.24e-01	-3.24e-01	-1.00e-01	-0.031600	2.69e-01	7.73e-01	1.12e-01	1.13e-01	6.24e-01	8.77e-01
tRNA processing in the nucleus	59	1.33e-06	7.47e-06	0.524	-1.50e-01	-2.47e-01	-3.45e-01	2.14e-01	7.95e-02	-0.140000	4.56e-02	1.01e-03	4.59e-06	4.38e-03	2.91e-01	6.21e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	4.14e-09	3.38e-08	0.524	-1.70e-01	-3.69e-01	-2.99e-01	1.18e-01	7.72e-02	-0.014700	1.03e-02	2.67e-08	6.47e-06	7.62e-02	2.45e-01	8.24e-01
DNA Damage Recognition in GG-NER	38	3.27e-04	1.12e-03	0.524	-1.32e-01	-3.82e-01	-2.80e-01	1.64e-01	-3.64e-02	-0.066900	1.59e-01	4.61e-05	2.79e-03	8.03e-02	6.98e-01	4.75e-01
VxPx cargo-targeting to cilium	19	1.43e-02	3.04e-02	0.524	-2.63e-01	1.70e-01	2.64e-01	2.63e-02	-8.89e-02	0.313000	4.76e-02	1.99e-01	4.61e-02	8.43e-01	5.02e-01	1.81e-02
Regulation of TP53 Activity through Acetylation	29	3.74e-04	1.26e-03	0.524	1.03e-01	1.06e-01	-6.10e-02	4.61e-01	1.11e-01	-0.156000	3.36e-01	3.21e-01	5.70e-01	1.76e-05	3.01e-01	1.47e-01
Signal transduction by L1	20	3.44e-02	6.39e-02	0.523	-2.41e-01	-2.94e-01	2.02e-01	-5.24e-02	-2.41e-01	0.165000	6.17e-02	2.26e-02	1.17e-01	6.85e-01	6.20e-02	2.03e-01
Prevention of phagosomal-lysosomal fusion	9	3.35e-01	4.01e-01	0.523	-2.59e-01	-3.79e-01	-3.23e-02	1.23e-01	-2.05e-01	0.063000	1.78e-01	4.90e-02	8.67e-01	5.21e-01	2.86e-01	7.44e-01
Synthesis of PIPs at the ER membrane	5	5.33e-01	5.88e-01	0.523	-5.75e-02	3.65e-01	-1.31e-01	1.60e-01	2.65e-01	0.155000	8.24e-01	1.58e-01	6.13e-01	5.36e-01	3.06e-01	5.48e-01
Nuclear events mediated by NFE2L2	81	1.79e-11	1.88e-10	0.522	-1.50e-01	-3.03e-01	2.45e-01	3.99e-02	-1.79e-01	0.255000	1.98e-02	2.34e-06	1.39e-04	5.35e-01	5.37e-03	7.41e-05
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.03e-02	4.06e-02	0.522	-1.39e-01	-4.28e-01	-1.90e-01	-5.31e-02	-1.19e-01	0.129000	2.70e-01	6.81e-04	1.32e-01	6.73e-01	3.46e-01	3.06e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.03e-02	4.06e-02	0.522	-1.39e-01	-4.28e-01	-1.90e-01	-5.31e-02	-1.19e-01	0.129000	2.70e-01	6.81e-04	1.32e-01	6.73e-01	3.46e-01	3.06e-01
GP1b-IX-V activation signalling	10	2.59e-01	3.29e-01	0.522	2.83e-02	-3.15e-01	2.36e-01	-1.23e-01	-3.07e-01	0.087100	8.77e-01	8.50e-02	1.97e-01	5.00e-01	9.32e-02	6.33e-01
Viral Messenger RNA Synthesis	44	8.91e-06	4.30e-05	0.521	-1.18e-01	-1.84e-01	-2.61e-01	3.46e-01	1.38e-01	-0.129000	1.76e-01	3.44e-02	2.75e-03	7.19e-05	1.12e-01	1.38e-01
Inwardly rectifying K+ channels	22	6.39e-02	1.06e-01	0.520	-1.75e-01	6.09e-02	3.17e-01	-1.95e-01	-2.21e-01	0.221000	1.55e-01	6.21e-01	1.02e-02	1.14e-01	7.27e-02	7.33e-02
Apoptotic execution phase	46	6.57e-05	2.68e-04	0.519	-2.90e-01	-1.19e-01	1.15e-01	-5.73e-02	-2.07e-01	0.334000	6.67e-04	1.61e-01	1.77e-01	5.01e-01	1.50e-02	8.71e-05
Interleukin-6 family signaling	18	3.33e-02	6.22e-02	0.519	-9.07e-02	3.89e-01	1.94e-01	-5.39e-02	2.08e-01	0.161000	5.05e-01	4.28e-03	1.54e-01	6.92e-01	1.26e-01	2.38e-01
Translation of Structural Proteins 9694635	55	4.68e-08	3.22e-07	0.519	-2.08e-01	-2.15e-01	1.29e-01	1.83e-01	-2.16e-01	0.288000	7.72e-03	5.85e-03	9.75e-02	1.87e-02	5.62e-03	2.22e-04
Regulation of innate immune responses to cytosolic DNA	14	1.25e-01	1.82e-01	0.518	7.22e-02	-2.82e-01	-3.66e-01	1.85e-01	7.03e-02	-0.105000	6.40e-01	6.81e-02	1.78e-02	2.30e-01	6.49e-01	4.98e-01
Organic anion transporters	7	6.37e-01	6.83e-01	0.518	1.55e-01	-9.13e-02	-2.25e-01	2.64e-01	3.34e-01	-0.062700	4.78e-01	6.76e-01	3.04e-01	2.26e-01	1.25e-01	7.74e-01
Cytosolic tRNA aminoacylation	24	2.09e-03	5.80e-03	0.518	-1.06e-01	-4.77e-01	-1.06e-01	1.05e-01	-6.90e-03	0.085700	3.69e-01	5.23e-05	3.70e-01	3.71e-01	9.53e-01	4.67e-01
Extension of Telomeres	51	2.24e-07	1.38e-06	0.518	1.91e-02	-3.41e-01	-1.86e-01	3.34e-01	5.78e-02	0.041900	8.13e-01	2.51e-05	2.13e-02	3.69e-05	4.75e-01	6.05e-01
RHO GTPases activate PAKs	20	5.81e-02	9.89e-02	0.517	-1.26e-01	9.77e-03	3.09e-01	4.58e-02	-2.21e-01	0.325000	3.31e-01	9.40e-01	1.68e-02	7.23e-01	8.77e-02	1.19e-02
Interconversion of nucleotide di- and triphosphates	27	1.76e-03	4.98e-03	0.517	-1.20e-01	-4.70e-01	-1.38e-01	1.40e-02	-4.37e-02	0.101000	2.82e-01	2.32e-05	2.14e-01	9.00e-01	6.94e-01	3.62e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.01e-01	1.54e-01	0.516	-2.92e-01	-3.01e-01	-2.61e-01	-1.01e-01	-1.36e-02	0.112000	3.69e-02	3.19e-02	6.27e-02	4.73e-01	9.22e-01	4.23e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	1.01e-03	3.00e-03	0.516	-4.30e-02	2.89e-01	3.89e-01	1.41e-01	-2.11e-03	0.099600	7.10e-01	1.24e-02	7.59e-04	2.22e-01	9.85e-01	3.88e-01
Elevation of cytosolic Ca2+ levels	13	2.29e-01	2.97e-01	0.516	2.10e-01	-3.44e-02	3.44e-01	1.49e-01	-4.56e-02	0.280000	1.91e-01	8.30e-01	3.16e-02	3.52e-01	7.76e-01	8.06e-02
Adenylate cyclase inhibitory pathway	11	6.99e-02	1.14e-01	0.515	-1.10e-02	3.89e-01	2.61e-01	2.07e-01	2.70e-02	-0.050500	9.49e-01	2.55e-02	1.34e-01	2.34e-01	8.77e-01	7.72e-01
Golgi-to-ER retrograde transport	123	7.20e-16	1.10e-14	0.514	-1.05e-01	-1.85e-01	2.34e-01	1.43e-01	-1.75e-01	0.336000	4.38e-02	3.88e-04	7.39e-06	6.26e-03	8.06e-04	1.24e-10
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	1.81e-01	2.45e-01	0.514	-3.11e-01	-2.41e-01	6.14e-02	-5.37e-02	-3.05e-01	0.094900	3.69e-02	1.06e-01	6.81e-01	7.19e-01	4.06e-02	5.25e-01
Transcriptional Regulation by NPAS4	27	2.95e-04	1.02e-03	0.513	-2.33e-01	2.77e-01	3.12e-01	1.81e-02	2.42e-02	0.183000	3.60e-02	1.26e-02	4.98e-03	8.70e-01	8.28e-01	9.95e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	7.36e-01	7.70e-01	0.513	1.08e-01	1.34e-01	3.50e-01	1.71e-01	-6.12e-02	0.279000	6.21e-01	5.38e-01	1.09e-01	4.34e-01	7.79e-01	2.00e-01
Activation of BAD and translocation to mitochondria	15	3.42e-01	4.08e-01	0.512	-2.14e-01	-3.12e-01	-9.83e-05	-1.80e-01	-2.96e-01	-0.005060	1.52e-01	3.66e-02	9.99e-01	2.27e-01	4.75e-02	9.73e-01
tRNA Aminoacylation	42	6.57e-06	3.25e-05	0.512	-4.51e-02	-4.35e-01	-1.86e-01	1.80e-01	5.62e-02	0.019000	6.13e-01	1.05e-06	3.70e-02	4.31e-02	5.28e-01	8.31e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	9.60e-10	8.45e-09	0.512	-2.11e-01	-3.88e-01	-3.43e-02	2.43e-02	-7.68e-02	0.243000	1.45e-03	4.88e-09	6.05e-01	7.14e-01	2.47e-01	2.49e-04
Synthesis of DNA	108	8.20e-18	1.38e-16	0.512	-8.51e-02	-4.48e-01	-9.44e-02	1.06e-01	-9.27e-03	0.183000	1.26e-01	8.13e-16	9.02e-02	5.67e-02	8.68e-01	1.04e-03
Regulation of KIT signaling	15	8.15e-02	1.29e-01	0.512	-1.67e-01	1.64e-01	2.69e-01	1.46e-01	7.74e-02	0.327000	2.63e-01	2.71e-01	7.10e-02	3.29e-01	6.04e-01	2.82e-02
TLR3-mediated TICAM1-dependent programmed cell death	6	7.32e-01	7.67e-01	0.511	6.65e-02	1.68e-01	1.27e-01	3.49e-01	1.74e-01	0.245000	7.78e-01	4.75e-01	5.89e-01	1.39e-01	4.59e-01	2.99e-01
Cyclin E associated events during G1/S transition	73	3.39e-10	3.16e-09	0.511	-1.31e-01	-3.73e-01	8.69e-02	5.54e-02	-9.68e-02	0.292000	5.22e-02	3.66e-08	1.99e-01	4.14e-01	1.53e-01	1.62e-05
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	2.62e-01	3.32e-01	0.511	-2.13e-01	6.33e-02	2.29e-01	2.53e-01	2.81e-01	0.129000	3.65e-01	7.88e-01	3.32e-01	2.84e-01	2.34e-01	5.85e-01
Depolymerization of the Nuclear Lamina	15	4.44e-02	7.84e-02	0.511	-2.87e-01	-1.38e-01	2.69e-01	7.48e-02	-2.01e-01	0.203000	5.45e-02	3.56e-01	7.16e-02	6.16e-01	1.78e-01	1.73e-01
SLC15A4:TASL-dependent IRF5 activation	6	2.51e-01	3.20e-01	0.510	-4.37e-01	-6.99e-02	-1.02e-01	1.83e-01	-1.42e-01	0.000238	6.36e-02	7.67e-01	6.64e-01	4.37e-01	5.46e-01	9.99e-01
Acetylcholine regulates insulin secretion	9	1.10e-01	1.65e-01	0.510	-8.65e-03	1.98e-01	1.12e-01	1.16e-01	3.78e-01	-0.227000	9.64e-01	3.03e-01	5.59e-01	5.45e-01	4.93e-02	2.38e-01
E3 ubiquitin ligases ubiquitinate target proteins	51	1.47e-05	6.83e-05	0.510	-2.38e-01	-3.14e-01	3.00e-02	2.31e-02	-1.55e-01	0.282000	3.31e-03	1.03e-04	7.11e-01	7.75e-01	5.54e-02	5.04e-04
Platelet calcium homeostasis	22	3.23e-02	6.07e-02	0.510	4.76e-02	-7.01e-03	3.73e-01	1.77e-01	-6.06e-02	0.289000	6.99e-01	9.55e-01	2.46e-03	1.51e-01	6.23e-01	1.89e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	9	1.25e-01	1.82e-01	0.510	1.57e-01	2.83e-01	-3.31e-02	-3.15e-02	2.14e-01	0.327000	4.14e-01	1.42e-01	8.63e-01	8.70e-01	2.66e-01	8.90e-02
Organic cation transport	8	4.29e-01	4.92e-01	0.510	-8.88e-02	1.09e-01	3.12e-01	-1.92e-01	-3.24e-01	-0.032100	6.64e-01	5.94e-01	1.27e-01	3.48e-01	1.12e-01	8.75e-01
Organic cation/anion/zwitterion transport	8	4.29e-01	4.92e-01	0.510	-8.88e-02	1.09e-01	3.12e-01	-1.92e-01	-3.24e-01	-0.032100	6.64e-01	5.94e-01	1.27e-01	3.48e-01	1.12e-01	8.75e-01
Aryl hydrocarbon receptor signalling	6	5.39e-01	5.93e-01	0.510	-3.08e-01	-3.28e-01	-1.55e-01	6.01e-02	1.71e-01	-0.007290	1.91e-01	1.64e-01	5.10e-01	7.99e-01	4.69e-01	9.75e-01
Nuclear import of Rev protein	34	1.55e-04	5.84e-04	0.510	-1.50e-01	-8.82e-02	-2.51e-01	3.51e-01	1.71e-01	-0.118000	1.29e-01	3.74e-01	1.13e-02	3.95e-04	8.51e-02	2.33e-01
MAPK6/MAPK4 signaling	69	6.13e-08	4.08e-07	0.509	-2.44e-01	-2.45e-01	1.30e-01	-2.65e-02	-8.56e-02	0.339000	4.57e-04	4.37e-04	6.27e-02	7.03e-01	2.19e-01	1.14e-06
WNT5A-dependent internalization of FZD4	13	7.02e-03	1.67e-02	0.509	-1.82e-01	-2.29e-01	1.24e-01	3.94e-01	-5.01e-02	0.012100	2.55e-01	1.53e-01	4.40e-01	1.39e-02	7.54e-01	9.40e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	10	4.08e-02	7.38e-02	0.507	-1.08e-01	-1.86e-01	5.92e-02	4.43e-01	-8.63e-02	-0.062000	5.55e-01	3.08e-01	7.46e-01	1.52e-02	6.36e-01	7.34e-01
Glutathione synthesis and recycling	10	3.66e-02	6.71e-02	0.507	-5.21e-02	-2.85e-01	1.92e-01	5.38e-02	2.19e-01	0.293000	7.75e-01	1.18e-01	2.92e-01	7.68e-01	2.31e-01	1.09e-01
Activation of the pre-replicative complex	32	1.68e-04	6.21e-04	0.507	-2.17e-02	-3.29e-01	-1.59e-01	3.28e-01	1.20e-02	0.127000	8.32e-01	1.29e-03	1.19e-01	1.34e-03	9.06e-01	2.15e-01
MECP2 regulates transcription factors	5	5.04e-01	5.61e-01	0.507	-2.03e-01	4.25e-01	-8.49e-03	-1.36e-01	1.07e-01	0.070400	4.32e-01	9.96e-02	9.74e-01	5.99e-01	6.80e-01	7.85e-01
mRNA Capping	29	4.81e-03	1.20e-02	0.507	-2.45e-01	-3.82e-01	-1.92e-01	1.14e-01	-1.48e-02	0.012000	2.22e-02	3.65e-04	7.40e-02	2.86e-01	8.90e-01	9.11e-01
RHOT2 GTPase cycle	7	6.01e-01	6.51e-01	0.506	-8.00e-02	-2.07e-01	1.89e-01	7.14e-03	-4.02e-01	0.098100	7.14e-01	3.42e-01	3.87e-01	9.74e-01	6.55e-02	6.53e-01
FLT3 signaling by CBL mutants	7	6.66e-01	7.08e-01	0.506	-1.73e-01	-4.27e-01	-1.94e-01	1.62e-02	-7.12e-02	-0.027400	4.27e-01	5.03e-02	3.75e-01	9.41e-01	7.44e-01	9.00e-01
Serine biosynthesis	8	6.16e-01	6.65e-01	0.506	-1.24e-01	4.03e-02	3.28e-01	-1.59e-01	-6.97e-02	0.318000	5.43e-01	8.44e-01	1.08e-01	4.36e-01	7.33e-01	1.19e-01
EGFR downregulation	26	1.22e-03	3.59e-03	0.506	-1.52e-01	-3.52e-02	4.02e-01	-1.97e-02	-2.35e-01	0.118000	1.80e-01	7.56e-01	3.86e-04	8.62e-01	3.78e-02	2.98e-01
mRNA Splicing	211	5.69e-28	1.38e-26	0.506	-1.18e-01	-3.64e-01	-2.83e-01	1.67e-01	2.89e-02	0.023100	3.21e-03	7.68e-20	1.34e-12	2.97e-05	4.70e-01	5.64e-01
Signaling by LTK	10	3.50e-01	4.16e-01	0.505	1.37e-02	3.76e-01	2.57e-01	1.10e-01	1.76e-01	0.068800	9.40e-01	3.93e-02	1.60e-01	5.46e-01	3.36e-01	7.06e-01
SHC-related events triggered by IGF1R	7	5.89e-01	6.39e-01	0.505	-4.24e-02	2.40e-01	3.12e-01	1.69e-01	-3.00e-02	0.262000	8.46e-01	2.72e-01	1.53e-01	4.38e-01	8.91e-01	2.29e-01
PI-3K cascade:FGFR1	13	4.85e-02	8.42e-02	0.505	-2.83e-01	1.94e-01	1.14e-01	-1.72e-01	-3.05e-01	0.043400	7.76e-02	2.27e-01	4.77e-01	2.83e-01	5.66e-02	7.86e-01
SUMOylation of ubiquitinylation proteins	39	2.46e-05	1.11e-04	0.505	-1.41e-01	-1.18e-01	-2.60e-01	3.23e-01	8.11e-02	-0.205000	1.27e-01	2.01e-01	4.93e-03	4.86e-04	3.81e-01	2.64e-02
Rev-mediated nuclear export of HIV RNA	35	2.29e-04	8.16e-04	0.505	-9.42e-02	-1.20e-01	-2.43e-01	3.56e-01	1.33e-01	-0.166000	3.35e-01	2.18e-01	1.29e-02	2.64e-04	1.73e-01	8.94e-02
G2/M Checkpoints	126	1.25e-17	2.05e-16	0.504	-1.22e-01	-3.62e-01	6.88e-02	1.24e-01	-1.31e-01	0.266000	1.78e-02	2.32e-12	1.82e-01	1.58e-02	1.13e-02	2.45e-07
Signalling to ERKs	32	3.38e-03	8.88e-03	0.504	-2.27e-01	1.46e-02	3.00e-01	-2.99e-02	-1.77e-01	0.283000	2.65e-02	8.87e-01	3.30e-03	7.69e-01	8.36e-02	5.66e-03
Tight junction interactions	17	1.81e-01	2.45e-01	0.503	3.87e-02	-1.20e-01	-3.70e-01	-3.70e-02	6.88e-02	-0.307000	7.83e-01	3.91e-01	8.23e-03	7.92e-01	6.23e-01	2.83e-02
Glycine degradation	7	4.26e-01	4.91e-01	0.503	-4.57e-02	-1.86e-01	1.98e-01	3.26e-01	-1.10e-01	0.242000	8.34e-01	3.95e-01	3.65e-01	1.35e-01	6.14e-01	2.68e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	8.24e-02	1.30e-01	0.503	-1.85e-01	-1.10e-01	5.22e-02	1.06e-01	-3.26e-01	0.293000	2.67e-01	5.08e-01	7.54e-01	5.26e-01	5.04e-02	7.83e-02
RHOBTB GTPase Cycle	35	1.23e-03	3.59e-03	0.503	-2.25e-01	-2.34e-01	1.42e-01	5.63e-02	-1.61e-01	0.312000	2.10e-02	1.66e-02	1.45e-01	5.65e-01	9.85e-02	1.38e-03
Chromosome Maintenance	102	4.44e-15	6.26e-14	0.502	-3.28e-02	-4.16e-01	-1.40e-01	1.99e-01	-8.80e-02	0.108000	5.67e-01	3.97e-13	1.42e-02	5.23e-04	1.25e-01	6.02e-02
Interleukin-1 processing	8	4.97e-01	5.55e-01	0.502	5.31e-02	2.78e-01	-1.78e-02	1.63e-01	2.87e-01	-0.251000	7.95e-01	1.74e-01	9.30e-01	4.25e-01	1.59e-01	2.19e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	5.73e-01	6.25e-01	0.502	-1.00e-01	-9.31e-02	2.52e-01	1.11e-01	2.12e-01	0.336000	6.98e-01	7.18e-01	3.30e-01	6.66e-01	4.12e-01	1.93e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	5.73e-01	6.25e-01	0.502	-1.00e-01	-9.31e-02	2.52e-01	1.11e-01	2.12e-01	0.336000	6.98e-01	7.18e-01	3.30e-01	6.66e-01	4.12e-01	1.93e-01
SUMOylation of SUMOylation proteins	35	2.04e-04	7.37e-04	0.502	-1.29e-01	-9.12e-02	-2.35e-01	3.49e-01	1.74e-01	-0.141000	1.86e-01	3.50e-01	1.61e-02	3.58e-04	7.54e-02	1.50e-01
mRNA Splicing - Major Pathway	203	3.52e-26	7.85e-25	0.502	-1.23e-01	-3.55e-01	-2.80e-01	1.76e-01	2.93e-02	0.014500	2.54e-03	2.46e-18	6.32e-12	1.50e-05	4.72e-01	7.21e-01
Export of Viral Ribonucleoproteins from Nucleus	33	3.15e-04	1.08e-03	0.502	-1.18e-01	-4.10e-02	-2.38e-01	3.48e-01	1.69e-01	-0.173000	2.41e-01	6.83e-01	1.79e-02	5.47e-04	9.29e-02	8.55e-02
NOTCH2 intracellular domain regulates transcription	11	4.39e-02	7.77e-02	0.502	-3.71e-02	3.31e-01	3.17e-01	1.04e-01	1.09e-01	-0.133000	8.31e-01	5.70e-02	6.91e-02	5.52e-01	5.33e-01	4.46e-01
Synthesis of PIPs at the late endosome membrane	11	3.38e-02	6.29e-02	0.501	-3.74e-01	1.09e-01	-8.19e-02	-2.79e-02	-1.51e-01	0.263000	3.17e-02	5.30e-01	6.38e-01	8.73e-01	3.85e-01	1.31e-01
Negative regulation of MET activity	18	6.69e-02	1.10e-01	0.501	-9.39e-02	9.31e-02	2.58e-01	6.43e-02	-2.18e-01	0.339000	4.90e-01	4.94e-01	5.77e-02	6.37e-01	1.10e-01	1.28e-02
Insulin processing	18	3.61e-02	6.66e-02	0.501	-2.48e-01	1.98e-01	1.84e-01	-2.24e-02	5.28e-02	0.335000	6.83e-02	1.45e-01	1.76e-01	8.69e-01	6.98e-01	1.38e-02
Histidine catabolism	7	4.12e-01	4.76e-01	0.500	-8.72e-02	1.71e-01	1.78e-02	-4.62e-01	2.72e-03	0.012500	6.89e-01	4.34e-01	9.35e-01	3.44e-02	9.90e-01	9.54e-01
RHO GTPases activate CIT	18	7.40e-02	1.20e-01	0.500	5.29e-04	-1.43e-01	2.49e-01	1.89e-01	-1.46e-01	0.333000	9.97e-01	2.94e-01	6.74e-02	1.64e-01	2.85e-01	1.45e-02
PI-3K cascade:FGFR4	11	1.29e-01	1.87e-01	0.500	-2.59e-01	2.52e-01	2.44e-01	-4.69e-02	-1.54e-01	0.183000	1.37e-01	1.48e-01	1.60e-01	7.88e-01	3.76e-01	2.94e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	1.17e-02	2.56e-02	0.499	-5.46e-02	-3.49e-01	1.92e-01	-3.80e-02	-2.33e-01	0.176000	6.43e-01	3.05e-03	1.03e-01	7.48e-01	4.79e-02	1.36e-01
Platelet Aggregation (Plug Formation)	28	1.55e-02	3.26e-02	0.499	-3.90e-02	-2.66e-01	1.86e-01	-1.34e-01	-3.44e-01	0.072100	7.21e-01	1.49e-02	8.87e-02	2.18e-01	1.60e-03	5.09e-01
Interactions of Rev with host cellular proteins	37	1.36e-04	5.18e-04	0.498	-1.23e-01	-1.24e-01	-2.55e-01	3.46e-01	1.34e-01	-0.124000	1.94e-01	1.92e-01	7.34e-03	2.72e-04	1.60e-01	1.92e-01
Myogenesis	20	2.17e-03	5.98e-03	0.497	-1.63e-01	3.72e-01	2.77e-01	5.24e-02	3.74e-02	0.034800	2.06e-01	3.96e-03	3.20e-02	6.85e-01	7.72e-01	7.87e-01
Assembly of active LPL and LIPC lipase complexes	10	3.60e-01	4.26e-01	0.497	1.54e-02	-1.81e-01	2.77e-01	-4.03e-02	-3.66e-01	0.049900	9.33e-01	3.23e-01	1.30e-01	8.25e-01	4.53e-02	7.85e-01
NrCAM interactions	6	7.93e-01	8.25e-01	0.497	1.99e-01	2.52e-01	-1.50e-01	6.89e-02	3.21e-01	-0.116000	3.98e-01	2.85e-01	5.25e-01	7.70e-01	1.73e-01	6.22e-01
Signaling by CSF3 (G-CSF)	29	1.37e-03	3.96e-03	0.496	-2.98e-01	5.10e-02	1.68e-01	4.38e-02	-4.20e-02	0.351000	5.49e-03	6.34e-01	1.17e-01	6.83e-01	6.95e-01	1.09e-03
Synthesis of PIPs at the early endosome membrane	16	9.00e-03	2.03e-02	0.495	-3.09e-01	2.31e-01	-2.79e-03	8.63e-02	1.10e-01	0.277000	3.23e-02	1.10e-01	9.85e-01	5.50e-01	4.46e-01	5.47e-02
ATF4 activates genes in response to endoplasmic reticulum stress	25	8.45e-02	1.33e-01	0.495	-2.14e-01	-3.29e-01	-2.19e-01	-1.66e-01	-6.07e-02	-0.109000	6.34e-02	4.39e-03	5.85e-02	1.50e-01	5.99e-01	3.47e-01
Activation of RAS in B cells	5	8.64e-01	8.87e-01	0.495	3.75e-02	2.87e-01	2.54e-01	4.48e-02	5.50e-02	0.304000	8.85e-01	2.67e-01	3.26e-01	8.62e-01	8.31e-01	2.40e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	5.19e-04	1.68e-03	0.495	-1.44e-01	-7.13e-02	-2.48e-01	3.31e-01	1.52e-01	-0.156000	1.57e-01	4.85e-01	1.51e-02	1.18e-03	1.38e-01	1.26e-01
Late SARS-CoV-2 Infection Events	63	4.52e-08	3.12e-07	0.494	-2.01e-01	-1.86e-01	1.68e-01	1.57e-01	-1.89e-01	0.285000	5.86e-03	1.07e-02	2.12e-02	3.11e-02	9.43e-03	9.36e-05
MET promotes cell motility	31	1.18e-02	2.58e-02	0.494	-3.16e-01	-5.44e-02	1.77e-01	-2.23e-01	-2.23e-01	0.101000	2.30e-03	6.00e-01	8.88e-02	3.13e-02	3.16e-02	3.29e-01
IRE1alpha activates chaperones	46	4.10e-10	3.75e-09	0.493	-1.61e-01	-1.56e-01	1.62e-01	3.20e-01	-2.48e-01	0.049100	5.93e-02	6.75e-02	5.68e-02	1.71e-04	3.59e-03	5.64e-01
Surfactant metabolism	19	1.11e-01	1.66e-01	0.493	-1.63e-01	-1.43e-01	1.71e-01	-3.36e-01	-1.67e-01	0.159000	2.18e-01	2.81e-01	1.96e-01	1.11e-02	2.08e-01	2.31e-01
G1/S Transition	120	2.39e-17	3.79e-16	0.492	-8.83e-02	-3.57e-01	3.85e-02	1.48e-01	-6.46e-02	0.282000	9.49e-02	1.36e-11	4.66e-01	5.20e-03	2.22e-01	9.84e-08
Metabolism of cofactors	25	1.09e-02	2.42e-02	0.492	-1.73e-01	-4.28e-01	-1.64e-01	-3.54e-02	1.54e-02	-0.024500	1.35e-01	2.11e-04	1.55e-01	7.60e-01	8.94e-01	8.32e-01
Transport of the SLBP Dependant Mature mRNA	36	2.02e-04	7.33e-04	0.492	-1.41e-01	-1.07e-01	-2.52e-01	3.12e-01	1.16e-01	-0.191000	1.43e-01	2.64e-01	8.82e-03	1.22e-03	2.29e-01	4.72e-02
NF-kB is activated and signals survival	12	1.65e-01	2.27e-01	0.492	-1.62e-01	-3.06e-01	-8.60e-02	3.53e-02	-1.65e-01	-0.294000	3.30e-01	6.67e-02	6.06e-01	8.32e-01	3.23e-01	7.79e-02
Signaling by NOTCH4	68	2.09e-07	1.31e-06	0.492	-2.19e-01	-3.49e-01	8.61e-02	8.15e-03	-1.55e-01	0.201000	1.78e-03	6.28e-07	2.19e-01	9.07e-01	2.74e-02	4.17e-03
Postmitotic nuclear pore complex (NPC) reformation	27	1.58e-03	4.51e-03	0.492	-1.99e-01	-1.74e-01	-2.45e-01	3.05e-01	5.28e-02	-0.126000	7.35e-02	1.18e-01	2.74e-02	6.08e-03	6.35e-01	2.58e-01
Signal amplification	28	4.86e-03	1.21e-02	0.491	-2.61e-01	-1.13e-01	2.79e-01	-9.18e-03	-1.72e-01	0.230000	1.69e-02	3.00e-01	1.07e-02	9.33e-01	1.14e-01	3.50e-02
Signal regulatory protein family interactions	13	1.07e-01	1.62e-01	0.491	-2.66e-01	-1.16e-01	2.59e-01	8.23e-02	-2.47e-02	0.286000	9.67e-02	4.70e-01	1.06e-01	6.07e-01	8.77e-01	7.38e-02
NS1 Mediated Effects on Host Pathways	40	3.92e-05	1.69e-04	0.491	-2.00e-01	-4.39e-02	-3.00e-01	2.71e-01	1.51e-01	-0.109000	2.85e-02	6.31e-01	1.01e-03	2.98e-03	9.79e-02	2.33e-01
Downstream signaling events of B Cell Receptor (BCR)	68	5.35e-07	3.12e-06	0.490	-2.30e-01	-2.83e-01	9.32e-02	6.92e-03	-1.31e-01	0.285000	1.05e-03	5.52e-05	1.84e-01	9.21e-01	6.09e-02	4.75e-05
O-linked glycosylation of mucins	46	4.98e-04	1.62e-03	0.490	-4.53e-02	1.46e-01	3.77e-01	1.49e-02	-4.21e-02	0.268000	5.95e-01	8.57e-02	9.65e-06	8.62e-01	6.21e-01	1.64e-03
Global Genome Nucleotide Excision Repair (GG-NER)	84	2.84e-08	2.07e-07	0.489	-1.84e-01	-3.51e-01	-2.68e-01	7.20e-02	6.32e-02	-0.043900	3.61e-03	2.69e-08	2.22e-05	2.54e-01	3.17e-01	4.87e-01
Phosphorylation of the APC/C	20	6.66e-02	1.10e-01	0.489	-1.90e-01	-4.11e-01	-1.38e-01	-2.71e-02	-6.54e-02	0.103000	1.40e-01	1.48e-03	2.87e-01	8.34e-01	6.13e-01	4.25e-01
FGFR2b ligand binding and activation	6	3.53e-01	4.19e-01	0.489	4.19e-01	1.08e-01	-1.37e-01	1.72e-01	-3.97e-02	0.039400	7.53e-02	6.48e-01	5.60e-01	4.66e-01	8.66e-01	8.67e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	5.79e-03	1.41e-02	0.489	-2.17e-01	-3.75e-01	-1.50e-01	1.61e-01	7.04e-03	0.056000	5.13e-02	7.52e-04	1.79e-01	1.48e-01	9.50e-01	6.14e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	5.79e-03	1.41e-02	0.489	-2.17e-01	-3.75e-01	-1.50e-01	1.61e-01	7.04e-03	0.056000	5.13e-02	7.52e-04	1.79e-01	1.48e-01	9.50e-01	6.14e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	1.14e-06	6.43e-06	0.488	-1.59e-01	-3.48e-01	-2.53e-01	1.42e-01	9.08e-02	0.006880	3.04e-02	2.18e-06	5.81e-04	5.32e-02	2.16e-01	9.25e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	2.23e-04	7.98e-04	0.487	-1.29e-01	-3.77e-01	-2.09e-01	1.80e-01	-3.43e-02	-0.040400	1.49e-01	2.30e-05	1.93e-02	4.39e-02	7.00e-01	6.51e-01
HIV Transcription Elongation	42	2.23e-04	7.98e-04	0.487	-1.29e-01	-3.77e-01	-2.09e-01	1.80e-01	-3.43e-02	-0.040400	1.49e-01	2.30e-05	1.93e-02	4.39e-02	7.00e-01	6.51e-01
Tat-mediated elongation of the HIV-1 transcript	42	2.23e-04	7.98e-04	0.487	-1.29e-01	-3.77e-01	-2.09e-01	1.80e-01	-3.43e-02	-0.040400	1.49e-01	2.30e-05	1.93e-02	4.39e-02	7.00e-01	6.51e-01
Dual incision in TC-NER	63	1.43e-06	7.99e-06	0.487	-1.80e-01	-3.50e-01	-2.59e-01	9.84e-02	7.04e-02	0.026400	1.32e-02	1.52e-06	3.80e-04	1.77e-01	3.34e-01	7.17e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	6.17e-02	1.03e-01	0.487	1.76e-01	6.77e-04	2.88e-01	3.31e-01	-1.07e-01	-0.048800	2.71e-01	9.97e-01	7.19e-02	3.89e-02	5.06e-01	7.60e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	32	4.14e-03	1.06e-02	0.487	-1.52e-01	4.54e-02	2.60e-01	5.49e-02	-1.87e-01	0.327000	1.38e-01	6.57e-01	1.10e-02	5.91e-01	6.78e-02	1.37e-03
Leishmania infection	209	4.83e-28	1.19e-26	0.487	-1.17e-01	-1.76e-01	2.21e-01	1.76e-01	-1.99e-01	0.270000	3.66e-03	1.22e-05	3.88e-08	1.09e-05	6.81e-07	1.72e-11
Parasitic Infection Pathways	209	4.83e-28	1.19e-26	0.487	-1.17e-01	-1.76e-01	2.21e-01	1.76e-01	-1.99e-01	0.270000	3.66e-03	1.22e-05	3.88e-08	1.09e-05	6.81e-07	1.72e-11
Signaling by MAPK mutants	6	5.72e-01	6.25e-01	0.486	-8.65e-02	-8.86e-03	-1.29e-01	-1.36e-01	1.51e-01	-0.414000	7.14e-01	9.70e-01	5.85e-01	5.64e-01	5.23e-01	7.91e-02
Phenylalanine and tyrosine metabolism	9	1.31e-01	1.89e-01	0.486	1.92e-01	-3.83e-01	-1.86e-01	3.43e-02	1.25e-01	-0.031500	3.18e-01	4.64e-02	3.33e-01	8.58e-01	5.18e-01	8.70e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	29	2.60e-03	7.00e-03	0.486	-1.48e-01	-3.26e-01	1.13e-02	1.50e-01	-9.45e-02	0.276000	1.68e-01	2.37e-03	9.16e-01	1.61e-01	3.78e-01	1.00e-02
Prolactin receptor signaling	11	1.90e-01	2.56e-01	0.486	-2.96e-01	-1.24e-01	-1.73e-01	2.92e-02	2.07e-01	0.244000	8.97e-02	4.76e-01	3.22e-01	8.67e-01	2.35e-01	1.61e-01
Chemokine receptors bind chemokines	38	2.89e-04	1.01e-03	0.485	2.57e-01	4.44e-02	3.06e-01	-1.02e-01	-2.52e-01	-0.010100	6.16e-03	6.36e-01	1.11e-03	2.76e-01	7.09e-03	9.14e-01
Mucopolysaccharidoses	11	2.18e-01	2.84e-01	0.485	-2.60e-01	-1.27e-01	-1.34e-01	-2.20e-02	-1.56e-01	-0.331000	1.36e-01	4.67e-01	4.42e-01	9.00e-01	3.71e-01	5.75e-02
Free fatty acids regulate insulin secretion	10	3.65e-02	6.71e-02	0.485	-2.74e-01	1.53e-01	3.66e-01	-5.16e-02	1.16e-02	-0.014900	1.34e-01	4.01e-01	4.50e-02	7.77e-01	9.50e-01	9.35e-01
Pyrimidine catabolism	9	5.26e-01	5.82e-01	0.485	-1.57e-03	-1.95e-01	2.68e-01	-6.37e-02	-1.77e-01	0.300000	9.93e-01	3.10e-01	1.64e-01	7.41e-01	3.57e-01	1.20e-01
Antigen processing-Cross presentation	88	1.29e-08	9.81e-08	0.485	-2.57e-01	-2.81e-01	2.72e-02	-5.48e-02	-1.13e-01	0.272000	3.16e-05	5.32e-06	6.59e-01	3.74e-01	6.57e-02	1.02e-05
Interleukin-37 signaling	19	6.62e-02	1.09e-01	0.485	-5.85e-02	2.42e-01	3.11e-01	7.23e-02	-1.19e-01	0.238000	6.59e-01	6.73e-02	1.88e-02	5.86e-01	3.70e-01	7.30e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	9	4.01e-01	4.67e-01	0.485	3.88e-03	3.86e-01	1.23e-01	2.01e-01	1.40e-01	0.103000	9.84e-01	4.51e-02	5.24e-01	2.95e-01	4.66e-01	5.93e-01
Protein ubiquitination	71	2.64e-07	1.62e-06	0.484	-2.44e-01	-2.70e-01	4.93e-02	4.15e-02	-1.51e-01	0.274000	3.72e-04	8.54e-05	4.73e-01	5.46e-01	2.77e-02	6.53e-05
Signaling by Leptin	10	2.81e-01	3.50e-01	0.484	-1.27e-01	1.74e-01	4.02e-01	-6.18e-02	-7.72e-02	0.129000	4.87e-01	3.41e-01	2.78e-02	7.35e-01	6.73e-01	4.80e-01
Neurofascin interactions	5	8.18e-01	8.46e-01	0.484	1.44e-01	8.07e-02	2.77e-01	-2.53e-01	-2.29e-01	0.118000	5.78e-01	7.55e-01	2.84e-01	3.28e-01	3.75e-01	6.47e-01
Metabolism of Angiotensinogen to Angiotensins	12	2.58e-01	3.28e-01	0.483	-4.60e-02	2.01e-01	2.50e-01	-3.04e-01	1.18e-02	0.189000	7.83e-01	2.27e-01	1.33e-01	6.83e-02	9.44e-01	2.58e-01
Dissolution of Fibrin Clot	12	2.37e-03	6.45e-03	0.483	-1.84e-01	-2.23e-01	2.51e-01	-2.49e-01	3.74e-02	-0.152000	2.69e-01	1.81e-01	1.31e-01	1.36e-01	8.22e-01	3.63e-01
Degradation of beta-catenin by the destruction complex	72	3.69e-08	2.61e-07	0.483	-1.50e-01	-2.63e-01	1.37e-01	1.00e-01	-1.07e-01	0.318000	2.79e-02	1.16e-04	4.50e-02	1.42e-01	1.16e-01	2.97e-06
DNA Damage Reversal	8	4.84e-01	5.41e-01	0.483	-2.57e-02	-3.41e-01	-1.77e-01	2.50e-01	4.89e-02	-0.140000	9.00e-01	9.51e-02	3.85e-01	2.20e-01	8.11e-01	4.93e-01
Suppression of phagosomal maturation	12	1.88e-01	2.53e-01	0.482	-3.22e-01	-2.54e-01	-7.00e-02	1.46e-01	-1.14e-01	0.159000	5.37e-02	1.28e-01	6.75e-01	3.80e-01	4.94e-01	3.40e-01
Signaling by high-kinase activity BRAF mutants	33	2.27e-03	6.22e-03	0.482	-2.58e-01	-2.26e-01	2.21e-01	-6.36e-02	-1.71e-01	0.182000	1.04e-02	2.49e-02	2.79e-02	5.27e-01	9.00e-02	6.98e-02
Uptake and function of diphtheria toxin	6	1.73e-01	2.37e-01	0.482	-1.36e-01	-1.65e-01	3.53e-01	-1.11e-01	1.51e-01	0.164000	5.63e-01	4.84e-01	1.35e-01	6.38e-01	5.21e-01	4.86e-01
Heme biosynthesis	13	2.77e-01	3.47e-01	0.482	2.29e-01	-8.57e-02	-1.33e-01	2.72e-01	2.84e-01	-0.008250	1.52e-01	5.93e-01	4.05e-01	8.98e-02	7.63e-02	9.59e-01
PCP/CE pathway	74	2.04e-09	1.71e-08	0.481	-1.66e-01	-3.64e-01	9.83e-02	1.06e-01	-1.40e-01	0.176000	1.34e-02	6.15e-08	1.44e-01	1.16e-01	3.71e-02	8.68e-03
XBP1(S) activates chaperone genes	44	3.99e-09	3.28e-08	0.480	-1.32e-01	-1.72e-01	1.40e-01	3.40e-01	-2.19e-01	0.028700	1.29e-01	4.78e-02	1.07e-01	9.74e-05	1.21e-02	7.42e-01
Vitamin B2 (riboflavin) metabolism	6	6.31e-01	6.78e-01	0.480	3.55e-01	-7.21e-02	-5.34e-02	1.76e-01	2.45e-01	-0.073700	1.32e-01	7.60e-01	8.21e-01	4.55e-01	2.98e-01	7.55e-01
ADP signalling through P2Y purinoceptor 1	21	2.84e-02	5.45e-02	0.480	-2.37e-01	-3.03e-02	3.11e-01	8.95e-03	-9.06e-02	0.262000	6.00e-02	8.10e-01	1.36e-02	9.43e-01	4.72e-01	3.78e-02
CD28 dependent Vav1 pathway	12	1.31e-01	1.89e-01	0.480	-2.57e-01	1.35e-01	1.84e-02	9.77e-02	1.89e-01	0.317000	1.23e-01	4.18e-01	9.12e-01	5.58e-01	2.58e-01	5.70e-02
DNA Damage/Telomere Stress Induced Senescence	42	3.18e-05	1.39e-04	0.480	-1.27e-01	-3.48e-01	1.34e-01	1.35e-01	-1.55e-01	0.179000	1.53e-01	9.36e-05	1.32e-01	1.29e-01	8.15e-02	4.46e-02
Transport of the SLBP independent Mature mRNA	35	3.45e-04	1.18e-03	0.479	-1.53e-01	-8.39e-02	-2.40e-01	2.99e-01	1.25e-01	-0.192000	1.17e-01	3.91e-01	1.40e-02	2.19e-03	2.02e-01	4.96e-02
Class C/3 (Metabotropic glutamate/pheromone receptors)	10	4.06e-01	4.71e-01	0.479	-6.49e-02	8.81e-02	-1.76e-01	-2.63e-01	-8.63e-02	-0.332000	7.22e-01	6.30e-01	3.35e-01	1.50e-01	6.37e-01	6.95e-02
SARS-CoV-1-host interactions	94	8.53e-09	6.55e-08	0.479	-1.61e-01	-3.68e-01	-2.54e-01	4.25e-02	1.71e-02	-0.039100	7.03e-03	6.75e-10	2.10e-05	4.76e-01	7.74e-01	5.12e-01
G beta:gamma signalling through CDC42	17	1.55e-01	2.15e-01	0.479	-2.64e-01	-5.20e-02	1.49e-01	-4.80e-02	-1.16e-01	0.344000	5.98e-02	7.10e-01	2.86e-01	7.32e-01	4.08e-01	1.39e-02
Apoptotic cleavage of cellular proteins	35	1.42e-03	4.11e-03	0.478	-2.13e-01	-2.85e-02	1.55e-01	3.38e-02	-1.69e-01	0.359000	2.91e-02	7.70e-01	1.13e-01	7.29e-01	8.28e-02	2.38e-04
Activation of RAC1	11	2.07e-01	2.74e-01	0.478	-2.31e-01	2.10e-01	7.51e-02	-1.55e-01	3.79e-02	0.317000	1.85e-01	2.28e-01	6.66e-01	3.72e-01	8.28e-01	6.90e-02
Triglyceride biosynthesis	9	2.05e-01	2.72e-01	0.478	-1.64e-01	3.56e-01	6.30e-02	-2.13e-01	-1.26e-01	-0.098000	3.95e-01	6.47e-02	7.44e-01	2.69e-01	5.12e-01	6.11e-01
RHOBTB3 ATPase cycle	10	5.96e-02	1.01e-01	0.478	-2.09e-01	-2.16e-01	9.29e-02	3.37e-01	-1.24e-01	-0.018700	2.53e-01	2.37e-01	6.11e-01	6.52e-02	4.97e-01	9.18e-01
Na+/Cl- dependent neurotransmitter transporters	7	6.49e-01	6.94e-01	0.477	1.38e-01	2.01e-01	2.46e-01	-2.04e-01	-2.56e-01	0.031000	5.29e-01	3.57e-01	2.61e-01	3.49e-01	2.41e-01	8.87e-01
Evasion by RSV of host interferon responses	20	1.34e-02	2.89e-02	0.477	-4.00e-02	4.36e-02	-2.25e-02	3.56e-01	1.05e-01	0.293000	7.57e-01	7.36e-01	8.62e-01	5.81e-03	4.18e-01	2.33e-02
trans-Golgi Network Vesicle Budding	69	4.29e-07	2.54e-06	0.477	-3.30e-01	-2.48e-01	6.95e-02	-6.24e-04	-1.79e-01	0.143000	2.13e-06	3.62e-04	3.18e-01	9.93e-01	1.03e-02	4.04e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	3.06e-04	1.06e-03	0.477	-8.90e-02	-3.19e-01	-2.54e-01	1.77e-01	1.24e-01	0.080100	3.43e-01	6.68e-04	6.63e-03	5.85e-02	1.87e-01	3.93e-01
Selective autophagy	77	1.64e-06	9.03e-06	0.477	-1.68e-01	-3.54e-01	-6.45e-02	-4.62e-02	-2.32e-01	0.120000	1.09e-02	8.09e-08	3.28e-01	4.84e-01	4.37e-04	6.87e-02
FLT3 signaling in disease	27	7.20e-03	1.71e-02	0.477	-9.66e-02	1.80e-01	2.70e-01	2.01e-01	7.09e-02	0.259000	3.85e-01	1.05e-01	1.50e-02	7.08e-02	5.24e-01	1.99e-02
Heme signaling	45	5.49e-08	3.76e-07	0.476	-1.29e-01	3.13e-01	1.66e-01	2.62e-01	1.22e-01	0.037100	1.33e-01	2.81e-04	5.46e-02	2.34e-03	1.58e-01	6.67e-01
Signaling by BMP	23	2.74e-03	7.31e-03	0.476	-2.55e-01	3.27e-01	1.22e-01	-9.87e-03	1.33e-01	0.148000	3.42e-02	6.63e-03	3.10e-01	9.35e-01	2.70e-01	2.20e-01
Mitotic G1 phase and G1/S transition	138	1.80e-18	3.08e-17	0.476	-7.77e-02	-3.16e-01	8.22e-02	1.47e-01	-6.35e-02	0.296000	1.15e-01	1.37e-10	9.56e-02	2.93e-03	1.98e-01	1.84e-09
CLEC7A (Dectin-1) induces NFAT activation	11	2.00e-01	2.66e-01	0.475	-1.19e-01	2.62e-01	1.11e-01	1.96e-01	9.67e-02	0.288000	4.95e-01	1.32e-01	5.25e-01	2.61e-01	5.79e-01	9.85e-02
SUMOylation of DNA replication proteins	46	4.44e-06	2.28e-05	0.475	-6.58e-02	-1.27e-01	-1.24e-01	4.12e-01	1.30e-01	-0.055900	4.40e-01	1.37e-01	1.44e-01	1.36e-06	1.26e-01	5.12e-01
Syndecan interactions	23	3.09e-02	5.84e-02	0.473	-1.43e-01	-2.43e-01	1.73e-01	-1.77e-01	-2.83e-01	-0.060600	2.36e-01	4.41e-02	1.52e-01	1.42e-01	1.87e-02	6.15e-01
Glucagon signaling in metabolic regulation	26	1.05e-02	2.34e-02	0.473	-1.41e-01	8.82e-02	2.81e-01	1.26e-01	-1.34e-01	0.289000	2.13e-01	4.36e-01	1.32e-02	2.65e-01	2.36e-01	1.07e-02
Interleukin-35 Signalling	12	1.45e-01	2.05e-01	0.473	-2.67e-01	1.23e-02	1.62e-01	1.02e-01	-2.00e-01	0.275000	1.09e-01	9.41e-01	3.31e-01	5.41e-01	2.29e-01	9.90e-02
MAP2K and MAPK activation	36	9.15e-04	2.77e-03	0.473	-2.36e-01	-2.33e-01	2.29e-01	-4.28e-02	-1.58e-01	0.186000	1.44e-02	1.57e-02	1.75e-02	6.57e-01	1.00e-01	5.29e-02
Assembly Of The HIV Virion	15	6.11e-02	1.03e-01	0.473	-5.91e-02	-2.73e-01	-6.35e-02	3.37e-01	-1.01e-01	0.131000	6.92e-01	6.68e-02	6.70e-01	2.37e-02	4.99e-01	3.79e-01
COPI-dependent Golgi-to-ER retrograde traffic	90	1.00e-09	8.76e-09	0.473	-2.18e-02	-1.72e-01	2.35e-01	1.71e-01	-1.46e-01	0.295000	7.21e-01	4.73e-03	1.13e-04	5.11e-03	1.63e-02	1.27e-06
Regulation of gene expression in beta cells	7	6.85e-01	7.25e-01	0.472	4.35e-02	3.33e-01	2.89e-01	9.62e-02	1.12e-01	0.071700	8.42e-01	1.28e-01	1.85e-01	6.60e-01	6.08e-01	7.42e-01
AMPK inhibits chREBP transcriptional activation activity	6	8.55e-01	8.78e-01	0.472	-2.49e-01	-1.46e-01	-2.26e-01	-1.29e-01	-1.54e-01	-0.220000	2.91e-01	5.34e-01	3.38e-01	5.86e-01	5.13e-01	3.52e-01
Aflatoxin activation and detoxification	14	4.39e-03	1.11e-02	0.472	-2.28e-01	-3.01e-01	4.14e-02	1.12e-02	2.76e-01	0.045400	1.39e-01	5.12e-02	7.88e-01	9.42e-01	7.35e-02	7.69e-01
eNOS activation	10	3.03e-01	3.72e-01	0.472	-1.28e-01	-3.36e-01	-1.39e-01	6.28e-02	-5.77e-02	0.259000	4.85e-01	6.55e-02	4.47e-01	7.31e-01	7.52e-01	1.57e-01
Tie2 Signaling	16	7.30e-02	1.19e-01	0.472	-2.66e-01	5.88e-02	2.02e-01	1.01e-01	-3.42e-02	0.311000	6.53e-02	6.84e-01	1.63e-01	4.85e-01	8.13e-01	3.15e-02
mRNA Editing	8	7.54e-01	7.88e-01	0.472	1.10e-01	2.00e-01	3.00e-01	1.78e-01	-1.04e-02	0.220000	5.88e-01	3.27e-01	1.42e-01	3.82e-01	9.60e-01	2.82e-01
Signaling by KIT in disease	20	8.28e-03	1.91e-02	0.472	-2.29e-01	2.25e-01	7.90e-02	1.42e-01	9.91e-02	0.288000	7.58e-02	8.15e-02	5.41e-01	2.73e-01	4.43e-01	2.56e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	8.28e-03	1.91e-02	0.472	-2.29e-01	2.25e-01	7.90e-02	1.42e-01	9.91e-02	0.288000	7.58e-02	8.15e-02	5.41e-01	2.73e-01	4.43e-01	2.56e-02
HIV Transcription Initiation	45	1.60e-04	5.92e-04	0.472	-2.68e-01	-3.34e-01	-1.24e-01	3.11e-02	2.70e-02	0.148000	1.86e-03	1.06e-04	1.48e-01	7.18e-01	7.54e-01	8.61e-02
RNA Polymerase II HIV Promoter Escape	45	1.60e-04	5.92e-04	0.472	-2.68e-01	-3.34e-01	-1.24e-01	3.11e-02	2.70e-02	0.148000	1.86e-03	1.06e-04	1.48e-01	7.18e-01	7.54e-01	8.61e-02
RNA Polymerase II Promoter Escape	45	1.60e-04	5.92e-04	0.472	-2.68e-01	-3.34e-01	-1.24e-01	3.11e-02	2.70e-02	0.148000	1.86e-03	1.06e-04	1.48e-01	7.18e-01	7.54e-01	8.61e-02
RNA Polymerase II Transcription Initiation	45	1.60e-04	5.92e-04	0.472	-2.68e-01	-3.34e-01	-1.24e-01	3.11e-02	2.70e-02	0.148000	1.86e-03	1.06e-04	1.48e-01	7.18e-01	7.54e-01	8.61e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	1.60e-04	5.92e-04	0.472	-2.68e-01	-3.34e-01	-1.24e-01	3.11e-02	2.70e-02	0.148000	1.86e-03	1.06e-04	1.48e-01	7.18e-01	7.54e-01	8.61e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	1.60e-04	5.92e-04	0.472	-2.68e-01	-3.34e-01	-1.24e-01	3.11e-02	2.70e-02	0.148000	1.86e-03	1.06e-04	1.48e-01	7.18e-01	7.54e-01	8.61e-02
Membrane binding and targetting of GAG proteins	13	1.36e-01	1.94e-01	0.471	-4.46e-02	-2.80e-01	-9.11e-02	3.19e-01	-1.25e-02	0.178000	7.81e-01	8.06e-02	5.70e-01	4.65e-02	9.38e-01	2.66e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	1.36e-01	1.94e-01	0.471	-4.46e-02	-2.80e-01	-9.11e-02	3.19e-01	-1.25e-02	0.178000	7.81e-01	8.06e-02	5.70e-01	4.65e-02	9.38e-01	2.66e-01
Detoxification of Reactive Oxygen Species	30	2.06e-03	5.72e-03	0.471	-2.13e-01	-2.34e-01	1.68e-01	-1.39e-01	-1.09e-02	0.272000	4.31e-02	2.67e-02	1.12e-01	1.86e-01	9.17e-01	9.79e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	7.66e-02	1.23e-01	0.471	-1.01e-01	-4.22e-01	1.48e-02	2.15e-03	1.40e-01	0.117000	5.80e-01	2.08e-02	9.36e-01	9.91e-01	4.43e-01	5.20e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	8.70e-03	1.98e-02	0.471	-1.80e-01	-2.87e-01	1.15e-01	4.08e-02	-2.23e-01	0.207000	7.86e-02	5.00e-03	2.60e-01	6.89e-01	2.93e-02	4.26e-02
Fibronectin matrix formation	6	6.07e-01	6.56e-01	0.471	-6.90e-02	-1.50e-01	3.02e-01	9.09e-02	-2.98e-01	0.078300	7.70e-01	5.26e-01	2.00e-01	7.00e-01	2.07e-01	7.40e-01
Formation of axial mesoderm	6	8.25e-01	8.52e-01	0.471	2.81e-01	2.56e-01	2.30e-01	1.48e-01	-4.28e-02	-0.023700	2.34e-01	2.78e-01	3.29e-01	5.31e-01	8.56e-01	9.20e-01
Signaling by WNT in cancer	30	2.43e-04	8.62e-04	0.471	-1.15e-01	3.17e-01	2.22e-01	1.09e-01	-9.86e-02	0.192000	2.77e-01	2.69e-03	3.50e-02	3.02e-01	3.50e-01	6.81e-02
Activated NTRK2 signals through RAS	6	7.24e-01	7.59e-01	0.470	-2.09e-01	1.15e-01	2.53e-01	3.88e-02	-5.11e-02	0.310000	3.76e-01	6.25e-01	2.84e-01	8.69e-01	8.28e-01	1.88e-01
Activated NTRK3 signals through RAS	6	7.24e-01	7.59e-01	0.470	-2.09e-01	1.15e-01	2.53e-01	3.88e-02	-5.11e-02	0.310000	3.76e-01	6.25e-01	2.84e-01	8.69e-01	8.28e-01	1.88e-01
Activation of the phototransduction cascade	8	2.66e-01	3.34e-01	0.470	2.19e-01	1.75e-01	1.06e-01	-9.31e-02	-3.41e-01	0.079000	2.82e-01	3.91e-01	6.03e-01	6.48e-01	9.53e-02	6.99e-01
Synthesis of PIPs at the plasma membrane	52	5.63e-08	3.83e-07	0.470	-2.44e-01	2.69e-01	2.23e-01	6.07e-02	2.01e-02	0.188000	2.29e-03	8.03e-04	5.45e-03	4.49e-01	8.02e-01	1.92e-02
HDL assembly	6	4.02e-01	4.67e-01	0.470	-5.79e-02	3.39e-01	1.92e-01	2.55e-01	-1.05e-02	-0.001540	8.06e-01	1.50e-01	4.15e-01	2.79e-01	9.65e-01	9.95e-01
Other semaphorin interactions	16	7.60e-02	1.23e-01	0.470	-4.24e-02	2.13e-01	3.42e-01	1.11e-01	-1.65e-01	0.131000	7.69e-01	1.40e-01	1.79e-02	4.41e-01	2.54e-01	3.63e-01
Diseases associated with N-glycosylation of proteins	20	1.22e-01	1.79e-01	0.470	-2.11e-01	-3.82e-01	-1.35e-01	-1.29e-02	-8.01e-02	-0.072800	1.02e-01	3.10e-03	2.96e-01	9.20e-01	5.35e-01	5.73e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	5.62e-02	9.62e-02	0.469	1.45e-02	1.68e-01	4.04e-01	4.14e-02	-1.21e-01	0.112000	9.11e-01	1.95e-01	1.76e-03	7.48e-01	3.48e-01	3.86e-01
NoRC negatively regulates rRNA expression	60	1.95e-05	8.86e-05	0.469	-2.12e-01	-3.95e-01	-6.82e-02	-8.24e-03	-1.10e-01	0.051000	4.52e-03	1.23e-07	3.61e-01	9.12e-01	1.39e-01	4.95e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	8.08e-08	5.33e-07	0.469	-1.45e-01	1.01e-01	2.72e-01	2.48e-01	9.18e-04	0.232000	6.23e-02	1.93e-01	4.94e-04	1.50e-03	9.91e-01	2.94e-03
PI3K events in ERBB2 signaling	11	8.43e-02	1.33e-01	0.469	-2.22e-01	3.31e-01	1.71e-01	-1.25e-01	-5.50e-02	-0.116000	2.03e-01	5.70e-02	3.27e-01	4.75e-01	7.52e-01	5.07e-01
Negative epigenetic regulation of rRNA expression	63	9.20e-06	4.42e-05	0.469	-2.12e-01	-3.94e-01	-8.70e-02	1.43e-02	-1.02e-01	0.036500	3.60e-03	6.26e-08	2.33e-01	8.44e-01	1.60e-01	6.16e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.24e-03	3.62e-03	0.469	-1.11e-01	-3.17e-02	-1.95e-01	3.45e-01	1.79e-01	-0.130000	2.78e-01	7.56e-01	5.62e-02	7.29e-04	7.89e-02	2.02e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.24e-03	3.62e-03	0.469	-1.11e-01	-3.17e-02	-1.95e-01	3.45e-01	1.79e-01	-0.130000	2.78e-01	7.56e-01	5.62e-02	7.29e-04	7.89e-02	2.02e-01
Receptor Mediated Mitophagy	11	3.50e-01	4.16e-01	0.469	-5.14e-02	-3.55e-01	2.99e-02	9.05e-02	-2.27e-01	0.174000	7.68e-01	4.16e-02	8.64e-01	6.03e-01	1.91e-01	3.18e-01
Nucleotide Excision Repair	108	3.72e-10	3.45e-09	0.468	-1.56e-01	-3.23e-01	-2.65e-01	1.25e-01	5.44e-02	-0.042600	5.11e-03	6.45e-09	1.96e-06	2.45e-02	3.29e-01	4.44e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.72e-31	5.17e-30	0.468	-1.35e-01	-3.21e-01	-2.55e-01	1.80e-01	2.90e-02	0.007570	1.09e-04	2.91e-20	2.13e-13	2.36e-07	4.05e-01	8.28e-01
Sphingolipid de novo biosynthesis	34	9.01e-03	2.03e-02	0.468	-1.94e-01	-2.31e-01	9.25e-02	6.51e-03	-2.90e-01	0.188000	5.06e-02	1.96e-02	3.50e-01	9.48e-01	3.41e-03	5.78e-02
Constitutive Signaling by EGFRvIII	14	1.49e-01	2.09e-01	0.467	-1.29e-01	2.20e-01	2.57e-01	1.45e-01	-1.53e-02	0.257000	4.04e-01	1.54e-01	9.60e-02	3.49e-01	9.21e-01	9.54e-02
Signaling by EGFRvIII in Cancer	14	1.49e-01	2.09e-01	0.467	-1.29e-01	2.20e-01	2.57e-01	1.45e-01	-1.53e-02	0.257000	4.04e-01	1.54e-01	9.60e-02	3.49e-01	9.21e-01	9.54e-02
Signaling by FGFR2 IIIa TM	18	8.81e-02	1.37e-01	0.467	-7.82e-02	-3.86e-01	-1.84e-01	1.68e-01	-2.48e-02	0.025300	5.66e-01	4.59e-03	1.76e-01	2.17e-01	8.56e-01	8.52e-01
Metabolism of folate and pterines	16	4.18e-02	7.49e-02	0.467	-8.59e-02	-4.43e-01	-2.54e-02	9.73e-02	-5.05e-02	-0.047700	5.52e-01	2.17e-03	8.60e-01	5.00e-01	7.27e-01	7.41e-01
Potential therapeutics for SARS	147	2.22e-19	3.98e-18	0.466	1.61e-02	-1.74e-01	1.23e-01	2.94e-01	-1.23e-01	0.265000	7.36e-01	2.61e-04	1.00e-02	7.50e-10	1.01e-02	3.05e-08
COPI-mediated anterograde transport	92	4.84e-10	4.40e-09	0.466	-1.27e-01	-1.67e-01	1.81e-01	1.54e-01	-1.71e-01	0.296000	3.55e-02	5.70e-03	2.69e-03	1.06e-02	4.55e-03	9.39e-07
Erythropoietin activates Phospholipase C gamma (PLCG)	6	6.55e-01	6.97e-01	0.466	-2.14e-01	1.82e-01	3.20e-01	-4.56e-02	-3.74e-02	0.180000	3.65e-01	4.41e-01	1.75e-01	8.47e-01	8.74e-01	4.44e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	3.14e-04	1.08e-03	0.465	-1.27e-01	-3.56e-01	-1.95e-01	1.80e-01	-4.43e-02	-0.028300	1.46e-01	4.28e-05	2.52e-02	3.85e-02	6.11e-01	7.46e-01
Cyclin A:Cdk2-associated events at S phase entry	75	7.41e-09	5.73e-08	0.465	-1.09e-01	-3.48e-01	7.00e-02	6.94e-02	-7.70e-02	0.260000	1.02e-01	1.89e-07	2.94e-01	2.99e-01	2.49e-01	9.69e-05
Signaling by EGFR	47	7.91e-06	3.84e-05	0.465	-1.52e-01	4.94e-02	3.66e-01	4.52e-02	-1.72e-01	0.157000	7.10e-02	5.58e-01	1.39e-05	5.92e-01	4.16e-02	6.25e-02
HSF1 activation	25	1.85e-03	5.21e-03	0.465	2.73e-02	-2.29e-01	6.95e-02	3.52e-01	1.57e-01	0.093300	8.13e-01	4.71e-02	5.47e-01	2.28e-03	1.73e-01	4.19e-01
Negative regulation of FGFR1 signaling	25	1.30e-01	1.88e-01	0.464	-2.52e-01	-2.13e-01	4.05e-02	-1.31e-01	-2.92e-01	0.050400	2.94e-02	6.50e-02	7.26e-01	2.55e-01	1.15e-02	6.63e-01
RNA Polymerase II Transcription Termination	66	7.37e-06	3.63e-05	0.463	-1.35e-01	-3.22e-01	-2.59e-01	1.49e-01	-1.66e-02	-0.054300	5.84e-02	6.19e-06	2.74e-04	3.66e-02	8.16e-01	4.45e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	2.79e-01	3.48e-01	0.462	2.08e-01	-1.94e-01	1.30e-01	2.20e-01	-3.00e-02	-0.257000	3.40e-01	3.73e-01	5.51e-01	3.13e-01	8.91e-01	2.39e-01
DNA Damage Bypass	47	6.09e-05	2.52e-04	0.461	-1.56e-01	-2.99e-01	-2.43e-01	1.36e-01	8.74e-02	0.116000	6.40e-02	3.88e-04	3.94e-03	1.06e-01	3.00e-01	1.67e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	3.15e-01	3.84e-01	0.461	2.29e-01	3.17e-01	8.05e-02	-1.34e-02	2.30e-01	0.000542	1.24e-01	3.35e-02	5.90e-01	9.28e-01	1.23e-01	9.97e-01
RUNX3 regulates NOTCH signaling	14	2.16e-02	4.28e-02	0.461	-2.05e-02	3.00e-01	2.60e-01	6.42e-02	-1.35e-01	-0.180000	8.94e-01	5.22e-02	9.22e-02	6.78e-01	3.80e-01	2.44e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.93e-01	2.59e-01	0.461	-1.47e-01	-3.39e-01	-2.51e-01	-8.31e-02	-6.40e-02	-0.048000	2.56e-01	8.73e-03	5.20e-02	5.20e-01	6.20e-01	7.10e-01
Activation of G protein gated Potassium channels	18	2.63e-01	3.32e-01	0.461	-6.14e-02	6.39e-02	2.61e-01	-6.86e-02	-2.15e-01	0.292000	6.52e-01	6.39e-01	5.51e-02	6.14e-01	1.14e-01	3.17e-02
G protein gated Potassium channels	18	2.63e-01	3.32e-01	0.461	-6.14e-02	6.39e-02	2.61e-01	-6.86e-02	-2.15e-01	0.292000	6.52e-01	6.39e-01	5.51e-02	6.14e-01	1.14e-01	3.17e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	2.63e-01	3.32e-01	0.461	-6.14e-02	6.39e-02	2.61e-01	-6.86e-02	-2.15e-01	0.292000	6.52e-01	6.39e-01	5.51e-02	6.14e-01	1.14e-01	3.17e-02
Regulation of BACH1 activity	11	4.78e-01	5.36e-01	0.461	-2.50e-01	-2.88e-01	-1.71e-01	-1.18e-01	-4.14e-02	0.149000	1.50e-01	9.86e-02	3.27e-01	4.98e-01	8.12e-01	3.93e-01
Cardiogenesis	13	5.29e-02	9.09e-02	0.461	-1.44e-01	6.52e-02	-7.73e-02	3.94e-01	1.32e-01	-0.094400	3.69e-01	6.84e-01	6.29e-01	1.40e-02	4.10e-01	5.56e-01
Attachment of GPI anchor to uPAR	7	2.09e-01	2.75e-01	0.459	-2.24e-01	-1.01e-01	1.45e-01	1.44e-01	3.10e-01	0.113000	3.04e-01	6.44e-01	5.05e-01	5.10e-01	1.56e-01	6.04e-01
Downstream signal transduction	27	1.33e-02	2.86e-02	0.459	-1.24e-01	9.27e-02	2.91e-01	1.50e-01	4.95e-03	0.283000	2.64e-01	4.04e-01	8.89e-03	1.78e-01	9.64e-01	1.10e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	8.09e-05	3.24e-04	0.459	-2.27e-01	-1.66e-01	1.41e-01	-3.00e-02	-1.80e-01	0.281000	2.01e-03	2.39e-02	5.51e-02	6.83e-01	1.45e-02	1.31e-04
Transport to the Golgi and subsequent modification	170	6.87e-20	1.26e-18	0.459	-1.52e-01	-1.36e-01	1.91e-01	1.67e-01	-1.25e-01	0.298000	6.26e-04	2.21e-03	1.73e-05	1.73e-04	4.82e-03	1.87e-11
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	3.61e-07	2.16e-06	0.459	-1.44e-01	-2.11e-01	-2.52e-01	2.41e-01	5.86e-02	-0.142000	3.43e-02	1.95e-03	2.21e-04	3.99e-04	3.90e-01	3.74e-02
FGFR2 alternative splicing	25	5.81e-02	9.89e-02	0.459	-1.06e-01	-3.69e-01	-1.91e-01	7.79e-02	-1.17e-01	-0.085700	3.61e-01	1.42e-03	9.83e-02	5.00e-01	3.12e-01	4.58e-01
RNA Polymerase III Transcription Initiation	36	6.62e-03	1.58e-02	0.459	-6.06e-02	-3.58e-01	-2.34e-01	9.58e-02	-6.85e-02	-0.097500	5.29e-01	1.98e-04	1.50e-02	3.20e-01	4.77e-01	3.11e-01
Sema4D induced cell migration and growth-cone collapse	19	7.40e-02	1.20e-01	0.459	1.95e-02	-1.23e-01	2.90e-01	3.09e-02	-3.25e-01	0.064900	8.83e-01	3.54e-01	2.88e-02	8.16e-01	1.41e-02	6.24e-01
RIP-mediated NFkB activation via ZBP1	17	6.76e-02	1.11e-01	0.459	2.49e-02	2.31e-01	1.79e-01	2.81e-01	2.10e-01	-0.035600	8.59e-01	9.94e-02	2.03e-01	4.49e-02	1.33e-01	7.99e-01
Trafficking and processing of endosomal TLR	13	6.53e-02	1.08e-01	0.458	-3.29e-01	-2.14e-03	1.04e-01	7.99e-02	2.24e-01	0.183000	4.00e-02	9.89e-01	5.16e-01	6.18e-01	1.61e-01	2.52e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	7.12e-01	7.48e-01	0.457	-2.27e-01	8.75e-02	1.70e-01	-8.61e-02	-4.37e-02	0.333000	2.97e-01	6.89e-01	4.36e-01	6.93e-01	8.41e-01	1.27e-01
Lysosome Vesicle Biogenesis	32	2.48e-03	6.71e-03	0.457	-2.70e-01	-3.30e-01	-1.68e-02	1.08e-01	-1.05e-01	0.058900	8.14e-03	1.22e-03	8.69e-01	2.90e-01	3.04e-01	5.64e-01
PKA activation	15	2.06e-01	2.72e-01	0.456	-1.06e-02	1.90e-01	3.45e-01	1.35e-01	-7.11e-02	0.170000	9.43e-01	2.02e-01	2.06e-02	3.65e-01	6.33e-01	2.53e-01
Platelet activation, signaling and aggregation	219	1.19e-19	2.16e-18	0.455	-1.80e-01	-1.98e-01	2.01e-01	-2.26e-02	-2.38e-01	0.194000	4.69e-06	4.24e-07	2.92e-07	5.65e-01	1.27e-09	7.97e-07
ABC transporters in lipid homeostasis	14	2.99e-01	3.68e-01	0.455	2.32e-01	3.15e-01	-4.02e-02	1.73e-02	9.59e-02	-0.206000	1.32e-01	4.16e-02	7.95e-01	9.11e-01	5.34e-01	1.81e-01
Aggrephagy	34	1.17e-02	2.58e-02	0.454	-6.92e-02	-3.21e-01	1.09e-01	-8.25e-02	-2.53e-01	0.126000	4.85e-01	1.21e-03	2.73e-01	4.05e-01	1.06e-02	2.02e-01
Phospholipase C-mediated cascade; FGFR2	8	4.47e-01	5.09e-01	0.454	3.97e-01	1.34e-01	1.39e-02	-1.25e-02	1.73e-01	0.008810	5.16e-02	5.13e-01	9.46e-01	9.51e-01	3.98e-01	9.66e-01
Separation of Sister Chromatids	167	1.45e-17	2.36e-16	0.454	-1.40e-01	-2.95e-01	4.56e-02	7.32e-02	-1.35e-01	0.271000	1.74e-03	4.49e-11	3.09e-01	1.03e-01	2.67e-03	1.53e-09
ABC-family proteins mediated transport	81	2.19e-07	1.36e-06	0.453	-1.40e-01	-3.20e-01	9.46e-02	-2.56e-02	-1.51e-01	0.226000	2.95e-02	6.42e-07	1.41e-01	6.91e-01	1.88e-02	4.34e-04
Neutrophil degranulation	456	2.38e-49	1.72e-47	0.453	-2.51e-01	-7.46e-02	2.33e-01	-4.33e-04	-1.49e-01	0.246000	4.25e-20	6.37e-03	1.59e-17	9.87e-01	5.10e-08	2.23e-19
Gamma-carboxylation of protein precursors	6	8.42e-01	8.65e-01	0.452	1.39e-01	7.07e-02	2.49e-01	6.36e-02	7.65e-02	0.328000	5.55e-01	7.64e-01	2.90e-01	7.87e-01	7.46e-01	1.64e-01
Signaling by SCF-KIT	40	3.50e-04	1.19e-03	0.451	-1.65e-01	9.84e-02	2.79e-01	1.31e-01	-3.77e-02	0.265000	7.13e-02	2.81e-01	2.27e-03	1.51e-01	6.80e-01	3.78e-03
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	4.12e-02	7.42e-02	0.451	-7.42e-02	-3.68e-01	-2.20e-01	4.18e-02	-8.34e-02	-0.073300	4.97e-01	7.56e-04	4.40e-02	7.02e-01	4.45e-01	5.02e-01
Recycling pathway of L1	40	2.65e-04	9.33e-04	0.450	-1.59e-01	-2.05e-01	2.32e-01	8.91e-02	-2.30e-01	0.144000	8.27e-02	2.47e-02	1.12e-02	3.29e-01	1.18e-02	1.15e-01
Nephron development	5	9.19e-01	9.32e-01	0.450	1.97e-01	9.28e-02	2.34e-01	2.59e-01	1.04e-01	0.150000	4.46e-01	7.19e-01	3.64e-01	3.16e-01	6.88e-01	5.62e-01
Activation of gene expression by SREBF (SREBP)	42	5.98e-05	2.48e-04	0.449	-6.34e-02	1.38e-01	2.70e-01	2.67e-01	7.92e-02	0.167000	4.77e-01	1.21e-01	2.42e-03	2.77e-03	3.75e-01	6.07e-02
Laminin interactions	25	6.13e-02	1.03e-01	0.449	2.94e-02	1.11e-01	3.32e-01	-2.11e-01	-1.61e-01	0.087000	7.99e-01	3.38e-01	4.05e-03	6.76e-02	1.64e-01	4.52e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.88e-01	2.52e-01	0.449	-2.75e-01	-2.33e-02	2.53e-01	-8.27e-02	6.01e-02	0.226000	9.95e-02	8.89e-01	1.29e-01	6.20e-01	7.19e-01	1.75e-01
alpha-linolenic acid (ALA) metabolism	12	1.88e-01	2.52e-01	0.449	-2.75e-01	-2.33e-02	2.53e-01	-8.27e-02	6.01e-02	0.226000	9.95e-02	8.89e-01	1.29e-01	6.20e-01	7.19e-01	1.75e-01
Interleukin-4 and Interleukin-13 signaling	88	1.13e-06	6.37e-06	0.449	6.65e-02	2.03e-01	3.61e-01	-3.58e-02	-2.99e-02	0.152000	2.81e-01	1.01e-03	4.66e-09	5.61e-01	6.27e-01	1.39e-02
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	4.26e-01	4.91e-01	0.448	-1.30e-01	-3.00e-01	-1.09e-01	2.83e-01	2.05e-02	0.043700	5.01e-01	1.19e-01	5.70e-01	1.42e-01	9.15e-01	8.20e-01
Negative regulation of FGFR4 signaling	22	1.49e-01	2.08e-01	0.448	-2.78e-01	-2.07e-01	7.42e-02	-5.24e-02	-2.27e-01	0.145000	2.42e-02	9.26e-02	5.47e-01	6.71e-01	6.48e-02	2.40e-01
Processing of Capped Intronless Pre-mRNA	29	4.00e-02	7.28e-02	0.448	-1.69e-01	-3.08e-01	-2.59e-01	9.28e-02	-1.91e-02	-0.032000	1.15e-01	4.06e-03	1.58e-02	3.87e-01	8.59e-01	7.65e-01
activated TAK1 mediates p38 MAPK activation	23	7.12e-02	1.16e-01	0.448	-2.55e-01	-9.57e-02	2.41e-01	-9.98e-02	-1.38e-01	0.197000	3.43e-02	4.27e-01	4.50e-02	4.07e-01	2.52e-01	1.01e-01
Glutathione conjugation	26	5.28e-05	2.22e-04	0.447	-7.26e-02	-3.87e-01	4.18e-02	-1.34e-01	1.08e-01	0.119000	5.22e-01	6.41e-04	7.12e-01	2.39e-01	3.42e-01	2.93e-01
Activation of AMPK downstream of NMDARs	20	2.42e-01	3.12e-01	0.447	-4.53e-02	-1.30e-01	2.19e-01	-6.88e-02	-2.97e-01	0.201000	7.26e-01	3.13e-01	9.04e-02	5.94e-01	2.15e-02	1.21e-01
RUNX2 regulates genes involved in cell migration	6	5.07e-01	5.64e-01	0.447	-1.04e-01	1.13e-01	-9.62e-02	1.60e-01	4.34e-02	-0.374000	6.59e-01	6.33e-01	6.83e-01	4.98e-01	8.54e-01	1.13e-01
Activation of RAC1 downstream of NMDARs	7	4.71e-01	5.29e-01	0.447	-2.45e-01	-2.47e-01	1.83e-01	5.07e-02	-2.06e-01	0.013100	2.62e-01	2.58e-01	4.01e-01	8.16e-01	3.45e-01	9.52e-01
Nuclear Receptor transcription pathway	38	1.35e-05	6.29e-05	0.447	-5.47e-02	2.94e-01	1.53e-01	1.48e-01	2.06e-01	-0.149000	5.59e-01	1.72e-03	1.03e-01	1.14e-01	2.77e-02	1.12e-01
Interleukin-27 signaling	11	2.50e-01	3.19e-01	0.446	-2.64e-01	-1.14e-02	1.32e-01	8.51e-02	-2.12e-01	0.244000	1.30e-01	9.48e-01	4.50e-01	6.25e-01	2.23e-01	1.60e-01
Gap junction trafficking	27	1.87e-02	3.79e-02	0.446	-1.86e-02	-9.86e-02	3.18e-01	1.26e-01	-1.82e-01	0.197000	8.67e-01	3.75e-01	4.23e-03	2.59e-01	1.01e-01	7.60e-02
Synthesis of very long-chain fatty acyl-CoAs	22	2.05e-01	2.72e-01	0.446	-2.37e-01	-8.69e-02	1.59e-01	-2.07e-01	-1.44e-01	0.216000	5.45e-02	4.81e-01	1.96e-01	9.25e-02	2.43e-01	8.00e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	2.73e-01	3.42e-01	0.446	-1.95e-01	-2.72e-01	-2.62e-01	-1.22e-01	-2.75e-02	-0.052700	1.31e-01	3.53e-02	4.25e-02	3.45e-01	8.31e-01	6.83e-01
Growth hormone receptor signaling	20	1.46e-01	2.06e-01	0.446	-1.87e-02	9.97e-02	3.33e-01	-1.25e-01	9.71e-04	0.249000	8.85e-01	4.40e-01	9.90e-03	3.33e-01	9.94e-01	5.41e-02
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	1.10e-03	3.25e-03	0.446	-1.19e-01	-3.50e-01	-1.88e-01	3.78e-02	-1.13e-01	-0.112000	1.37e-01	1.30e-05	1.88e-02	6.38e-01	1.57e-01	1.62e-01
SHC1 events in ERBB4 signaling	10	1.38e-01	1.97e-01	0.445	-2.49e-01	2.40e-01	2.28e-01	-1.01e-01	1.27e-01	-0.023000	1.72e-01	1.89e-01	2.12e-01	5.80e-01	4.88e-01	9.00e-01
Prostacyclin signalling through prostacyclin receptor	16	2.58e-01	3.29e-01	0.445	-1.63e-01	-2.13e-01	1.31e-01	5.62e-02	-1.80e-01	0.272000	2.58e-01	1.40e-01	3.66e-01	6.97e-01	2.13e-01	6.00e-02
SUMOylation of transcription factors	16	3.43e-01	4.10e-01	0.445	-9.73e-02	-1.18e-01	-2.73e-01	1.28e-01	9.17e-02	-0.274000	5.00e-01	4.14e-01	5.83e-02	3.75e-01	5.25e-01	5.81e-02
Mitotic Anaphase	210	1.54e-21	2.93e-20	0.443	-1.50e-01	-2.95e-01	4.09e-02	8.77e-02	-1.32e-01	0.246000	1.88e-04	1.76e-13	3.07e-01	2.86e-02	1.00e-03	7.63e-10
FGFR1 mutant receptor activation	25	6.69e-03	1.60e-02	0.443	-3.09e-01	9.19e-02	1.84e-01	3.84e-02	-6.35e-02	0.230000	7.41e-03	4.26e-01	1.12e-01	7.39e-01	5.82e-01	4.69e-02
Nuclear Pore Complex (NPC) Disassembly	36	2.03e-04	7.37e-04	0.442	-1.35e-01	-4.04e-02	-1.50e-01	3.68e-01	1.29e-01	-0.039700	1.62e-01	6.75e-01	1.21e-01	1.34e-04	1.81e-01	6.80e-01
SUMOylation of immune response proteins	12	2.06e-01	2.72e-01	0.442	1.46e-01	4.54e-02	7.81e-02	3.41e-01	7.75e-02	-0.209000	3.82e-01	7.85e-01	6.40e-01	4.08e-02	6.42e-01	2.10e-01
Mitotic Metaphase and Anaphase	211	1.54e-21	2.93e-20	0.441	-1.46e-01	-2.94e-01	3.99e-02	9.02e-02	-1.30e-01	0.246000	2.63e-04	1.78e-13	3.17e-01	2.39e-02	1.12e-03	7.81e-10
ER to Golgi Anterograde Transport	145	3.49e-15	5.07e-14	0.441	-1.63e-01	-1.23e-01	1.84e-01	1.45e-01	-1.19e-01	0.290000	7.21e-04	1.04e-02	1.33e-04	2.63e-03	1.35e-02	1.68e-09
RHOC GTPase cycle	71	8.43e-08	5.54e-07	0.440	-6.82e-02	4.38e-02	2.99e-01	2.11e-01	-8.87e-02	0.213000	3.20e-01	5.24e-01	1.28e-05	2.16e-03	1.96e-01	1.90e-03
Defective RIPK1-mediated regulated necrosis	7	7.01e-01	7.39e-01	0.440	1.06e-01	3.60e-02	-1.54e-01	3.59e-01	1.55e-01	0.067500	6.26e-01	8.69e-01	4.81e-01	1.00e-01	4.78e-01	7.57e-01
Response of Mtb to phagocytosis	22	1.28e-02	2.78e-02	0.440	-2.01e-01	-1.89e-01	7.84e-02	2.17e-01	-2.00e-01	0.155000	1.02e-01	1.25e-01	5.24e-01	7.79e-02	1.04e-01	2.09e-01
DCC mediated attractive signaling	13	3.17e-01	3.85e-01	0.439	-1.61e-01	-3.14e-01	1.23e-01	4.26e-02	-1.82e-01	0.133000	3.14e-01	5.02e-02	4.41e-01	7.90e-01	2.55e-01	4.05e-01
Glycogen metabolism	21	1.16e-01	1.72e-01	0.438	-2.15e-01	-1.72e-01	4.19e-02	-9.05e-03	-2.94e-01	0.167000	8.84e-02	1.72e-01	7.40e-01	9.43e-01	1.96e-02	1.85e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	6.11e-02	1.03e-01	0.438	-9.75e-03	-2.64e-01	1.62e-01	3.07e-01	-1.39e-02	0.037000	9.51e-01	9.98e-02	3.12e-01	5.50e-02	9.31e-01	8.17e-01
SUMOylation of RNA binding proteins	47	1.37e-04	5.23e-04	0.437	-2.02e-01	-1.55e-01	-2.14e-01	2.26e-01	1.04e-01	-0.137000	1.65e-02	6.55e-02	1.10e-02	7.48e-03	2.19e-01	1.05e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	3.20e-01	3.87e-01	0.437	-3.37e-01	-7.49e-03	-1.63e-01	8.44e-02	-2.04e-02	0.207000	9.87e-02	9.71e-01	4.24e-01	6.79e-01	9.20e-01	3.11e-01
RNA Polymerase III Abortive And Retractive Initiation	40	7.39e-03	1.74e-02	0.436	-6.49e-02	-3.45e-01	-2.14e-01	7.57e-02	-6.23e-02	-0.104000	4.77e-01	1.58e-04	1.90e-02	4.08e-01	4.96e-01	2.55e-01
RNA Polymerase III Transcription	40	7.39e-03	1.74e-02	0.436	-6.49e-02	-3.45e-01	-2.14e-01	7.57e-02	-6.23e-02	-0.104000	4.77e-01	1.58e-04	1.90e-02	4.08e-01	4.96e-01	2.55e-01
Signaling by NODAL	15	4.68e-01	5.27e-01	0.436	-2.83e-01	-1.35e-01	-9.40e-03	-1.70e-01	-2.47e-01	-0.040900	5.79e-02	3.67e-01	9.50e-01	2.54e-01	9.78e-02	7.84e-01
KEAP1-NFE2L2 pathway	106	1.59e-10	1.49e-09	0.435	-1.60e-01	-2.44e-01	1.92e-01	5.78e-02	-1.66e-01	0.190000	4.39e-03	1.37e-05	6.42e-04	3.04e-01	3.08e-03	7.08e-04
Cell Cycle Checkpoints	245	1.30e-25	2.71e-24	0.435	-1.24e-01	-3.05e-01	2.51e-02	1.13e-01	-1.19e-01	0.230000	8.24e-04	2.00e-16	4.99e-01	2.40e-03	1.28e-03	5.32e-10
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	6.31e-01	6.78e-01	0.433	-2.15e-01	-2.19e-03	-7.13e-02	-1.28e-01	6.50e-02	-0.341000	3.62e-01	9.93e-01	7.62e-01	5.88e-01	7.83e-01	1.48e-01
Transcriptional Regulation by MECP2	47	6.97e-04	2.18e-03	0.433	-5.33e-02	2.26e-01	1.91e-01	1.81e-01	1.08e-01	0.230000	5.27e-01	7.41e-03	2.33e-02	3.20e-02	2.00e-01	6.32e-03
Sema4D in semaphorin signaling	22	4.20e-02	7.51e-02	0.433	1.81e-02	-1.49e-01	2.70e-01	4.63e-02	-2.98e-01	0.037900	8.83e-01	2.27e-01	2.81e-02	7.07e-01	1.57e-02	7.58e-01
Cell-extracellular matrix interactions	15	2.85e-01	3.53e-01	0.433	-8.94e-02	-1.93e-01	1.65e-01	1.16e-01	-2.00e-01	0.248000	5.49e-01	1.96e-01	2.69e-01	4.35e-01	1.80e-01	9.58e-02
COPII-mediated vesicle transport	67	5.61e-07	3.26e-06	0.433	-2.32e-01	-8.32e-02	1.71e-01	1.29e-01	-5.54e-02	0.279000	1.05e-03	2.39e-01	1.52e-02	6.78e-02	4.33e-01	7.77e-05
Late endosomal microautophagy	30	4.41e-03	1.12e-02	0.433	-8.18e-02	-3.13e-01	1.07e-01	1.74e-01	-9.31e-02	0.180000	4.38e-01	3.00e-03	3.11e-01	9.85e-02	3.78e-01	8.78e-02
Methylation	13	6.34e-01	6.80e-01	0.433	-2.58e-01	-2.47e-01	-2.05e-01	-8.15e-02	-9.99e-02	-0.032800	1.08e-01	1.23e-01	2.00e-01	6.11e-01	5.33e-01	8.38e-01
RHOV GTPase cycle	36	1.93e-04	7.05e-04	0.433	-1.11e-01	1.98e-01	8.55e-02	2.49e-01	4.79e-02	0.253000	2.50e-01	3.97e-02	3.75e-01	9.74e-03	6.19e-01	8.55e-03
CLEC7A/inflammasome pathway	6	3.68e-01	4.34e-01	0.432	-1.17e-01	2.13e-01	1.33e-01	5.62e-02	1.92e-01	-0.265000	6.21e-01	3.66e-01	5.72e-01	8.11e-01	4.14e-01	2.62e-01
Pyrimidine salvage	10	5.19e-01	5.74e-01	0.432	-1.94e-01	-2.90e-01	7.99e-02	4.05e-02	-2.34e-01	0.045500	2.88e-01	1.12e-01	6.62e-01	8.24e-01	2.00e-01	8.03e-01
Respiratory syncytial virus (RSV) attachment and entry	17	1.93e-02	3.89e-02	0.432	-8.72e-02	1.55e-01	2.54e-01	2.81e-01	-7.45e-02	0.080000	5.34e-01	2.69e-01	6.99e-02	4.51e-02	5.95e-01	5.68e-01
RHOBTB2 GTPase cycle	23	5.64e-02	9.65e-02	0.432	-1.25e-01	-1.58e-01	9.74e-02	1.40e-01	-7.45e-02	0.334000	2.98e-01	1.90e-01	4.19e-01	2.44e-01	5.36e-01	5.61e-03
Triglyceride metabolism	24	4.24e-02	7.57e-02	0.432	-2.18e-01	1.52e-01	2.32e-01	-5.69e-02	-1.29e-01	0.205000	6.42e-02	1.97e-01	4.88e-02	6.29e-01	2.76e-01	8.22e-02
Gluconeogenesis	19	3.70e-03	9.59e-03	0.432	-6.41e-02	-2.24e-01	2.07e-01	1.91e-01	1.66e-01	0.159000	6.29e-01	9.07e-02	1.19e-01	1.50e-01	2.09e-01	2.30e-01
RNA Polymerase I Transcription Initiation	47	4.20e-03	1.07e-02	0.431	-8.34e-02	-2.30e-01	-2.61e-01	1.52e-01	9.89e-02	-0.159000	3.23e-01	6.46e-03	1.98e-03	7.06e-02	2.41e-01	5.97e-02
Synthesis, secretion, and deacylation of Ghrelin	11	2.53e-01	3.22e-01	0.431	-1.88e-01	-1.58e-01	-2.13e-01	-1.65e-01	1.31e-01	0.189000	2.80e-01	3.65e-01	2.22e-01	3.43e-01	4.52e-01	2.79e-01
Host Interactions of HIV factors	118	2.39e-12	2.70e-11	0.430	-1.77e-01	-3.01e-01	-1.14e-01	1.98e-01	-3.06e-02	0.101000	8.82e-04	1.64e-08	3.27e-02	2.00e-04	5.66e-01	5.84e-02
Transport of RCbl within the body	8	6.24e-01	6.74e-01	0.430	7.30e-02	-2.89e-01	-4.90e-03	-5.78e-02	-3.01e-01	0.045600	7.21e-01	1.57e-01	9.81e-01	7.77e-01	1.40e-01	8.23e-01
Trafficking of GluR2-containing AMPA receptors	11	1.97e-01	2.63e-01	0.430	-4.21e-02	-1.98e-01	2.23e-01	2.60e-01	-1.32e-01	0.097400	8.09e-01	2.56e-01	2.00e-01	1.36e-01	4.48e-01	5.76e-01
Neurexins and neuroligins	34	2.98e-02	5.66e-02	0.430	8.62e-02	2.59e-01	1.51e-02	1.29e-01	2.76e-01	-0.133000	3.84e-01	9.04e-03	8.79e-01	1.92e-01	5.39e-03	1.79e-01
P2Y receptors	10	5.38e-01	5.93e-01	0.430	-1.03e-01	1.70e-01	1.51e-01	5.38e-03	1.65e-01	0.309000	5.73e-01	3.52e-01	4.09e-01	9.77e-01	3.66e-01	9.10e-02
Peroxisomal protein import	58	6.58e-05	2.68e-04	0.429	-1.95e-01	-3.27e-01	-1.70e-01	-3.08e-02	5.43e-02	0.081800	1.02e-02	1.63e-05	2.54e-02	6.85e-01	4.74e-01	2.81e-01
RHO GTPase Effectors	257	1.38e-22	2.74e-21	0.429	-1.19e-01	-1.64e-01	1.81e-01	7.96e-02	-1.63e-01	0.278000	1.07e-03	5.72e-06	5.46e-07	2.80e-02	6.97e-06	1.47e-14
RHO GTPases Activate Rhotekin and Rhophilins	8	5.21e-01	5.76e-01	0.429	1.02e-01	-3.13e-01	-2.06e-01	-9.12e-02	-1.48e-01	-0.061400	6.18e-01	1.26e-01	3.14e-01	6.55e-01	4.69e-01	7.64e-01
UCH proteinases	73	4.11e-07	2.44e-06	0.429	-1.37e-01	-3.05e-01	7.97e-02	1.22e-01	-1.04e-01	0.200000	4.31e-02	6.36e-06	2.39e-01	7.21e-02	1.25e-01	3.18e-03
Transcription of the HIV genome	67	9.97e-06	4.77e-05	0.429	-2.08e-01	-3.19e-01	-1.32e-01	1.23e-01	-2.92e-02	0.071400	3.19e-03	6.30e-06	6.08e-02	8.16e-02	6.80e-01	3.13e-01
Mitochondrial unfolded protein response (UPRmt)	17	1.38e-01	1.97e-01	0.429	6.91e-02	-1.97e-02	-8.73e-02	1.87e-01	1.78e-01	-0.323000	6.22e-01	8.88e-01	5.33e-01	1.81e-01	2.04e-01	2.11e-02
Downregulation of ERBB2:ERBB3 signaling	12	6.35e-01	6.82e-01	0.428	-3.94e-02	-1.06e-01	-3.37e-01	3.52e-02	6.63e-02	-0.227000	8.13e-01	5.27e-01	4.32e-02	8.33e-01	6.91e-01	1.73e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	2.65e-01	3.34e-01	0.428	-1.88e-01	-8.17e-02	1.49e-01	-5.26e-02	-1.28e-01	0.316000	1.55e-01	5.37e-01	2.62e-01	6.91e-01	3.32e-01	1.70e-02
Senescence-Associated Secretory Phenotype (SASP)	64	5.03e-05	2.13e-04	0.427	-8.18e-02	-3.30e-01	8.66e-02	-4.28e-02	-2.31e-01	0.065100	2.58e-01	4.98e-06	2.31e-01	5.53e-01	1.41e-03	3.68e-01
RNA Polymerase I Promoter Clearance	64	1.09e-04	4.23e-04	0.427	-1.36e-01	-3.67e-01	-1.34e-01	4.05e-02	-9.14e-02	-0.026200	6.01e-02	3.66e-07	6.32e-02	5.76e-01	2.06e-01	7.17e-01
RNA Polymerase I Transcription	64	1.09e-04	4.23e-04	0.427	-1.36e-01	-3.67e-01	-1.34e-01	4.05e-02	-9.14e-02	-0.026200	6.01e-02	3.66e-07	6.32e-02	5.76e-01	2.06e-01	7.17e-01
Phase 0 - rapid depolarisation	22	2.34e-01	3.03e-01	0.427	1.63e-01	2.37e-01	2.83e-01	-4.98e-02	3.36e-02	0.126000	1.87e-01	5.46e-02	2.14e-02	6.86e-01	7.85e-01	3.07e-01
Calcineurin activates NFAT	9	2.98e-01	3.67e-01	0.426	-2.72e-01	1.15e-02	-4.92e-03	1.11e-01	-1.16e-01	0.285000	1.57e-01	9.53e-01	9.80e-01	5.64e-01	5.45e-01	1.39e-01
Resolution of Sister Chromatid Cohesion	115	6.82e-11	6.58e-10	0.426	-1.04e-01	-1.83e-01	1.03e-01	1.48e-01	-1.41e-01	0.291000	5.34e-02	7.09e-04	5.52e-02	6.06e-03	9.11e-03	7.30e-08
NGF-stimulated transcription	32	5.96e-04	1.89e-03	0.425	-2.86e-01	1.72e-01	6.17e-02	-2.00e-01	1.55e-01	-0.042900	5.17e-03	9.21e-02	5.46e-01	4.99e-02	1.29e-01	6.74e-01
Transport of Mature Transcript to Cytoplasm	81	5.19e-07	3.04e-06	0.425	-1.29e-01	-2.28e-01	-2.19e-01	2.23e-01	2.69e-02	-0.116000	4.48e-02	3.93e-04	6.38e-04	5.26e-04	6.75e-01	7.10e-02
IL-6-type cytokine receptor ligand interactions	12	2.43e-01	3.13e-01	0.425	-8.15e-02	2.48e-01	5.68e-02	-2.65e-01	1.25e-01	-0.151000	6.25e-01	1.37e-01	7.33e-01	1.11e-01	4.55e-01	3.64e-01
GPVI-mediated activation cascade	31	3.28e-03	8.65e-03	0.424	-1.43e-01	1.16e-01	2.21e-01	1.75e-01	-8.99e-02	0.243000	1.69e-01	2.65e-01	3.29e-02	9.26e-02	3.86e-01	1.94e-02
Purine catabolism	16	3.72e-01	4.37e-01	0.424	-1.07e-01	-3.57e-01	-1.18e-01	-1.05e-01	-1.23e-01	-0.030900	4.59e-01	1.33e-02	4.14e-01	4.69e-01	3.94e-01	8.30e-01
SUMOylation of chromatin organization proteins	57	1.50e-05	6.93e-05	0.424	-1.58e-01	-1.04e-01	-1.91e-01	2.78e-01	1.47e-01	-0.093000	3.90e-02	1.74e-01	1.28e-02	2.82e-04	5.43e-02	2.25e-01
Activation of Matrix Metalloproteinases	20	4.11e-02	7.40e-02	0.424	1.08e-01	8.10e-02	3.77e-01	1.71e-02	-1.35e-01	-0.025500	4.02e-01	5.30e-01	3.47e-03	8.95e-01	2.97e-01	8.43e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	73	1.67e-07	1.06e-06	0.424	-1.64e-01	-3.18e-02	3.33e-01	-3.05e-02	-9.75e-02	0.175000	1.55e-02	6.39e-01	8.72e-07	6.52e-01	1.50e-01	9.68e-03
Inactivation of CSF3 (G-CSF) signaling	24	4.94e-02	8.55e-02	0.424	-2.56e-01	-1.13e-02	9.31e-02	1.06e-02	1.68e-02	0.323000	2.97e-02	9.24e-01	4.30e-01	9.28e-01	8.87e-01	6.11e-03
Azathioprine ADME	20	2.95e-02	5.62e-02	0.424	-1.57e-01	-3.51e-01	3.71e-02	6.29e-02	4.59e-02	0.156000	2.25e-01	6.58e-03	7.74e-01	6.26e-01	7.22e-01	2.28e-01
RAB geranylgeranylation	61	9.57e-05	3.76e-04	0.423	-2.67e-01	-8.11e-02	1.18e-01	-5.69e-03	-1.29e-01	0.265000	3.02e-04	2.73e-01	1.12e-01	9.39e-01	8.09e-02	3.44e-04
cGMP effects	12	1.08e-01	1.62e-01	0.423	8.54e-02	-9.61e-02	5.53e-02	1.31e-01	-1.00e-01	-0.363000	6.09e-01	5.64e-01	7.40e-01	4.33e-01	5.47e-01	2.92e-02
Synthesis of 12-eicosatetraenoic acid derivatives	6	7.64e-01	7.97e-01	0.423	1.09e-01	-2.94e-01	-1.31e-01	-1.00e-01	-1.92e-01	-0.126000	6.44e-01	2.12e-01	5.78e-01	6.71e-01	4.15e-01	5.92e-01
HIV Infection	213	6.07e-22	1.18e-20	0.423	-1.78e-01	-3.05e-01	-9.68e-02	1.71e-01	-3.36e-02	0.118000	7.23e-06	1.65e-14	1.49e-02	1.62e-05	3.99e-01	3.10e-03
MET activates RAS signaling	10	5.41e-01	5.95e-01	0.422	-7.04e-02	2.13e-01	2.42e-01	3.52e-03	-1.57e-01	0.212000	7.00e-01	2.43e-01	1.86e-01	9.85e-01	3.90e-01	2.46e-01
Cholesterol biosynthesis	26	9.26e-03	2.08e-02	0.422	6.69e-02	-2.74e-01	1.81e-01	1.17e-01	-4.43e-02	0.225000	5.55e-01	1.58e-02	1.10e-01	3.03e-01	6.96e-01	4.70e-02
Formation of paraxial mesoderm	52	1.45e-04	5.51e-04	0.422	-8.30e-02	-2.80e-01	1.35e-01	8.18e-02	-1.07e-01	0.238000	3.00e-01	4.75e-04	9.28e-02	3.07e-01	1.81e-01	3.02e-03
Sema3A PAK dependent Axon repulsion	15	3.19e-01	3.87e-01	0.422	-4.49e-02	9.14e-02	2.53e-01	1.81e-01	-5.68e-02	0.261000	7.63e-01	5.40e-01	9.02e-02	2.26e-01	7.04e-01	8.03e-02
TRAF6 mediated IRF7 activation	15	3.91e-01	4.56e-01	0.422	6.26e-02	2.19e-01	8.22e-02	2.84e-01	1.51e-01	0.125000	6.75e-01	1.41e-01	5.81e-01	5.68e-02	3.12e-01	4.04e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	7.79e-01	8.12e-01	0.421	1.58e-01	-3.07e-02	1.56e-01	6.56e-02	2.08e-01	0.283000	5.41e-01	9.05e-01	5.47e-01	7.99e-01	4.20e-01	2.74e-01
ADORA2B mediated anti-inflammatory cytokines production	35	1.53e-02	3.24e-02	0.421	-1.47e-01	-2.46e-03	2.30e-01	6.74e-02	-1.43e-01	0.279000	1.33e-01	9.80e-01	1.84e-02	4.90e-01	1.42e-01	4.33e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	6.81e-02	1.11e-01	0.421	-2.32e-02	2.42e-01	3.02e-01	2.69e-02	-1.05e-01	-0.124000	8.80e-01	1.17e-01	5.06e-02	8.61e-01	4.96e-01	4.22e-01
Inactivation, recovery and regulation of the phototransduction cascade	25	2.52e-02	4.91e-02	0.421	1.13e-02	-1.89e-01	-7.79e-02	-2.14e-01	-2.89e-01	0.077200	9.22e-01	1.02e-01	5.00e-01	6.43e-02	1.24e-02	5.04e-01
EPH-Ephrin signaling	79	2.42e-07	1.48e-06	0.420	-1.93e-01	-1.04e-01	1.73e-01	1.00e-01	-1.97e-01	0.223000	2.96e-03	1.10e-01	7.68e-03	1.23e-01	2.53e-03	6.05e-04
Chaperone Mediated Autophagy	20	1.51e-01	2.11e-01	0.420	-1.97e-01	-3.08e-01	9.52e-02	-5.21e-02	-1.36e-01	0.112000	1.27e-01	1.73e-02	4.61e-01	6.87e-01	2.91e-01	3.84e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	7.37e-04	2.28e-03	0.420	-1.12e-01	-1.32e-01	-2.05e-01	2.73e-01	6.92e-02	-0.157000	2.03e-01	1.34e-01	2.01e-02	1.92e-03	4.32e-01	7.45e-02
Glutamate Neurotransmitter Release Cycle	19	4.07e-01	4.72e-01	0.419	2.04e-01	2.02e-01	1.61e-01	1.33e-01	2.17e-01	0.048000	1.23e-01	1.27e-01	2.23e-01	3.16e-01	1.02e-01	7.17e-01
Synthesis of PC	23	1.60e-01	2.21e-01	0.419	-2.80e-01	-1.59e-01	-3.62e-03	-7.99e-02	-2.56e-01	0.008090	2.02e-02	1.87e-01	9.76e-01	5.07e-01	3.36e-02	9.46e-01
ZBP1(DAI) mediated induction of type I IFNs	20	9.98e-02	1.53e-01	0.418	3.65e-02	2.44e-01	1.69e-01	2.25e-01	1.84e-01	-0.031900	7.78e-01	5.88e-02	1.91e-01	8.11e-02	1.54e-01	8.05e-01
Nucleotide catabolism	28	9.05e-02	1.41e-01	0.418	-2.50e-01	-2.92e-01	-3.05e-02	-7.11e-02	-7.71e-02	0.122000	2.21e-02	7.39e-03	7.80e-01	5.15e-01	4.80e-01	2.63e-01
Cellular hexose transport	14	1.35e-01	1.93e-01	0.418	1.48e-01	3.29e-03	4.72e-02	1.39e-01	3.47e-01	-0.103000	3.38e-01	9.83e-01	7.60e-01	3.66e-01	2.44e-02	5.06e-01
p75NTR signals via NF-kB	15	1.06e-01	1.60e-01	0.418	-2.11e-01	-2.39e-01	-7.60e-03	-2.54e-02	-1.02e-01	-0.249000	1.58e-01	1.10e-01	9.59e-01	8.65e-01	4.95e-01	9.45e-02
Myoclonic epilepsy of Lafora	8	7.34e-01	7.69e-01	0.418	-1.39e-01	-3.07e-01	-1.55e-01	3.32e-02	-1.67e-01	0.087900	4.95e-01	1.32e-01	4.48e-01	8.71e-01	4.14e-01	6.67e-01
Plasma lipoprotein remodeling	18	2.11e-02	4.19e-02	0.417	2.37e-02	-1.36e-01	3.10e-01	1.19e-01	-2.09e-01	-0.034500	8.62e-01	3.17e-01	2.27e-02	3.81e-01	1.25e-01	8.00e-01
Constitutive Signaling by Overexpressed ERBB2	11	4.82e-01	5.39e-01	0.417	-1.33e-01	1.13e-02	2.31e-01	1.49e-01	-6.13e-02	0.277000	4.46e-01	9.48e-01	1.85e-01	3.92e-01	7.25e-01	1.12e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.10e-01	4.75e-01	0.416	-2.53e-01	-2.26e-01	4.39e-02	-2.27e-02	-1.98e-01	0.131000	8.02e-02	1.18e-01	7.61e-01	8.75e-01	1.71e-01	3.65e-01
Transport and synthesis of PAPS	6	8.35e-01	8.59e-01	0.416	-3.58e-01	-1.56e-01	-6.15e-03	-7.98e-02	-1.00e-02	0.119000	1.28e-01	5.09e-01	9.79e-01	7.35e-01	9.66e-01	6.15e-01
Metabolism of nucleotides	85	2.41e-07	1.48e-06	0.416	-1.59e-01	-3.55e-01	-1.09e-01	6.90e-02	-1.08e-03	0.069900	1.13e-02	1.45e-08	8.14e-02	2.71e-01	9.86e-01	2.65e-01
Signaling by RAF1 mutants	36	1.30e-02	2.82e-02	0.416	-2.27e-01	-2.04e-01	1.73e-01	-5.05e-02	-1.46e-01	0.162000	1.83e-02	3.45e-02	7.25e-02	6.00e-01	1.31e-01	9.16e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	1.73e-02	3.55e-02	0.416	-1.77e-01	-2.13e-01	1.35e-02	2.71e-01	-1.37e-01	0.059100	1.61e-01	9.04e-02	9.15e-01	3.14e-02	2.76e-01	6.39e-01
Signaling by FGFR3 in disease	14	3.15e-01	3.84e-01	0.416	-1.69e-01	2.22e-01	2.15e-01	-1.05e-01	-1.07e-01	0.163000	2.73e-01	1.51e-01	1.65e-01	4.98e-01	4.87e-01	2.90e-01
Phase 2 - plateau phase	11	4.41e-01	5.04e-01	0.416	-9.64e-02	2.08e-01	1.37e-01	-1.04e-01	2.04e-01	0.221000	5.80e-01	2.32e-01	4.33e-01	5.48e-01	2.42e-01	2.04e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	5.72e-02	9.78e-02	0.415	-2.25e-02	-2.95e-02	-6.69e-02	2.14e-01	1.58e-01	-0.309000	8.69e-01	8.29e-01	6.23e-01	1.16e-01	2.45e-01	2.31e-02
Deactivation of the beta-catenin transactivating complex	36	2.66e-02	5.14e-02	0.415	7.55e-02	1.16e-01	6.00e-02	3.16e-01	1.53e-01	0.163000	4.33e-01	2.29e-01	5.33e-01	1.04e-03	1.13e-01	9.15e-02
mRNA 3’-end processing	57	4.47e-04	1.48e-03	0.415	-1.39e-01	-2.72e-01	-2.33e-01	1.44e-01	-3.58e-02	-0.048400	6.85e-02	3.91e-04	2.31e-03	5.92e-02	6.40e-01	5.28e-01
Vesicle-mediated transport	660	1.58e-66	3.36e-64	0.414	-1.32e-01	-1.50e-01	1.64e-01	1.51e-01	-1.40e-01	0.249000	6.58e-09	5.02e-11	6.02e-13	3.80e-11	7.85e-10	8.16e-28
GABA receptor activation	35	3.24e-02	6.08e-02	0.413	-3.10e-02	2.03e-01	2.76e-01	-7.15e-02	-1.52e-01	0.155000	7.51e-01	3.76e-02	4.76e-03	4.64e-01	1.20e-01	1.12e-01
Gap junction trafficking and regulation	29	4.11e-02	7.40e-02	0.413	-7.58e-03	-7.94e-02	3.02e-01	9.82e-02	-1.54e-01	0.198000	9.44e-01	4.59e-01	4.85e-03	3.60e-01	1.50e-01	6.51e-02
Pregnenolone biosynthesis	10	2.79e-01	3.48e-01	0.412	1.11e-01	-3.01e-01	-7.76e-02	1.50e-01	1.67e-01	-0.105000	5.45e-01	9.97e-02	6.71e-01	4.11e-01	3.61e-01	5.65e-01
ERBB2 Regulates Cell Motility	10	3.33e-01	3.99e-01	0.412	-3.27e-01	3.90e-02	2.00e-03	-1.60e-01	3.01e-03	-0.189000	7.31e-02	8.31e-01	9.91e-01	3.80e-01	9.87e-01	3.01e-01
p38MAPK events	13	4.45e-01	5.08e-01	0.412	-1.01e-01	2.50e-02	2.78e-01	1.04e-01	-3.59e-02	0.264000	5.29e-01	8.76e-01	8.28e-02	5.17e-01	8.23e-01	9.87e-02
Downstream signaling of activated FGFR3	17	1.18e-01	1.75e-01	0.412	-1.51e-01	2.21e-01	2.16e-01	1.69e-02	-1.36e-01	0.181000	2.81e-01	1.15e-01	1.23e-01	9.04e-01	3.30e-01	1.97e-01
Regulation of beta-cell development	21	2.77e-02	5.32e-02	0.412	-9.72e-04	2.72e-01	2.98e-01	5.00e-02	-3.27e-02	-0.058800	9.94e-01	3.07e-02	1.82e-02	6.91e-01	7.95e-01	6.41e-01
Activation of C3 and C5	7	6.26e-01	6.75e-01	0.412	8.66e-02	-1.88e-01	-6.27e-02	4.69e-02	-3.54e-02	-0.346000	6.92e-01	3.90e-01	7.74e-01	8.30e-01	8.71e-01	1.13e-01
RAS processing	23	1.36e-01	1.95e-01	0.412	-6.05e-02	-2.86e-01	-1.87e-02	-7.85e-02	-2.31e-01	0.156000	6.15e-01	1.76e-02	8.77e-01	5.14e-01	5.53e-02	1.96e-01
PKA activation in glucagon signalling	14	3.36e-01	4.02e-01	0.412	-1.54e-02	1.83e-01	2.64e-01	1.81e-01	-4.91e-02	0.175000	9.21e-01	2.36e-01	8.68e-02	2.41e-01	7.51e-01	2.56e-01
O-glycosylation of TSR domain-containing proteins	25	2.54e-02	4.94e-02	0.411	1.41e-01	3.07e-01	-1.63e-02	1.46e-01	9.13e-03	-0.183000	2.24e-01	7.79e-03	8.88e-01	2.08e-01	9.37e-01	1.13e-01
S Phase	150	1.20e-15	1.78e-14	0.411	-8.46e-02	-3.12e-01	-2.87e-02	1.23e-01	-3.61e-03	0.220000	7.39e-02	4.05e-11	5.44e-01	9.15e-03	9.39e-01	3.45e-06
FGFR2 mutant receptor activation	23	8.80e-02	1.37e-01	0.411	1.04e-02	-3.26e-01	-2.19e-01	1.17e-01	1.28e-02	-0.028400	9.31e-01	6.81e-03	6.93e-02	3.32e-01	9.15e-01	8.14e-01
Rap1 signalling	14	3.65e-01	4.31e-01	0.410	-2.18e-01	4.53e-02	2.37e-01	-3.92e-02	-1.72e-01	0.178000	1.59e-01	7.69e-01	1.25e-01	8.00e-01	2.65e-01	2.49e-01
MET activates PTK2 signaling	21	1.96e-01	2.62e-01	0.410	-2.53e-01	-7.67e-02	1.42e-01	-2.50e-01	-9.66e-02	0.078100	4.45e-02	5.43e-01	2.60e-01	4.71e-02	4.44e-01	5.35e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	5.31e-01	5.86e-01	0.410	-1.52e-01	1.25e-01	5.78e-03	-1.85e-01	3.08e-01	-0.005250	4.87e-01	5.66e-01	9.79e-01	3.97e-01	1.58e-01	9.81e-01
Signaling by FGFR1 in disease	32	3.98e-03	1.02e-02	0.409	-2.59e-01	1.40e-01	1.86e-01	1.50e-02	-6.09e-02	0.206000	1.14e-02	1.70e-01	6.86e-02	8.83e-01	5.51e-01	4.38e-02
Transcriptional regulation of pluripotent stem cells	18	1.43e-01	2.03e-01	0.409	2.92e-02	2.16e-01	1.56e-01	-1.22e-01	-1.69e-01	0.228000	8.30e-01	1.13e-01	2.51e-01	3.70e-01	2.14e-01	9.42e-02
Activation of ATR in response to replication stress	37	1.83e-03	5.17e-03	0.409	8.98e-03	-2.41e-01	-1.35e-01	2.63e-01	2.05e-02	0.145000	9.25e-01	1.12e-02	1.54e-01	5.70e-03	8.29e-01	1.27e-01
Plasma lipoprotein assembly	10	1.54e-01	2.14e-01	0.408	-1.29e-01	1.33e-01	3.24e-01	1.65e-01	-1.61e-02	0.014500	4.79e-01	4.68e-01	7.63e-02	3.67e-01	9.30e-01	9.37e-01
Nucleotide-like (purinergic) receptors	13	5.03e-01	5.60e-01	0.408	-8.88e-02	6.57e-02	2.27e-01	-3.61e-02	6.32e-02	0.312000	5.79e-01	6.82e-01	1.56e-01	8.22e-01	6.93e-01	5.12e-02
Signaling by TGFBR3	39	6.61e-05	2.69e-04	0.408	-1.58e-01	1.91e-01	7.39e-02	2.73e-01	1.15e-01	0.107000	8.76e-02	3.92e-02	4.24e-01	3.13e-03	2.15e-01	2.46e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	2.35e-17	3.76e-16	0.408	-1.38e-01	-1.36e-01	1.45e-01	1.45e-01	-1.25e-01	0.267000	1.05e-03	1.20e-03	5.34e-04	5.60e-04	2.87e-03	2.07e-10
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	6.14e-02	1.03e-01	0.407	-1.90e-01	-2.88e-01	1.02e-01	-5.54e-02	-1.71e-01	-0.061800	1.31e-01	2.23e-02	4.18e-01	6.60e-01	1.74e-01	6.24e-01
Neurodegenerative Diseases	21	6.14e-02	1.03e-01	0.407	-1.90e-01	-2.88e-01	1.02e-01	-5.54e-02	-1.71e-01	-0.061800	1.31e-01	2.23e-02	4.18e-01	6.60e-01	1.74e-01	6.24e-01
Translation of Structural Proteins 9683701	29	1.08e-02	2.39e-02	0.407	-8.18e-02	-1.98e-01	3.58e-02	2.53e-01	-1.08e-01	0.207000	4.46e-01	6.54e-02	7.39e-01	1.84e-02	3.14e-01	5.34e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	182	1.02e-17	1.69e-16	0.407	4.14e-02	-1.20e-01	1.12e-01	2.05e-01	-1.51e-01	0.268000	3.36e-01	5.30e-03	8.88e-03	1.80e-06	4.24e-04	4.37e-10
Hemostasis	551	4.83e-48	3.20e-46	0.407	-8.03e-02	-1.55e-01	2.19e-01	9.16e-02	-1.85e-01	0.211000	1.28e-03	5.16e-10	1.27e-18	2.37e-04	1.14e-13	2.54e-17
Post-translational protein phosphorylation	66	1.55e-06	8.62e-06	0.407	-1.76e-01	-3.50e-02	3.11e-01	-1.89e-02	-6.02e-02	0.181000	1.32e-02	6.23e-01	1.25e-05	7.90e-01	3.98e-01	1.12e-02
Signaling by Hippo	18	2.17e-01	2.83e-01	0.407	-3.04e-01	7.22e-02	4.09e-02	-1.99e-01	-1.43e-01	0.078300	2.54e-02	5.96e-01	7.64e-01	1.44e-01	2.94e-01	5.65e-01
Xenobiotics	9	6.90e-01	7.29e-01	0.406	6.13e-02	1.64e-01	5.77e-02	1.50e-01	3.28e-01	-0.033400	7.50e-01	3.95e-01	7.64e-01	4.36e-01	8.86e-02	8.62e-01
Regulation of signaling by NODAL	6	8.03e-01	8.34e-01	0.406	-2.67e-01	1.23e-01	-8.56e-02	-2.66e-01	-1.25e-02	-0.002570	2.57e-01	6.02e-01	7.17e-01	2.59e-01	9.58e-01	9.91e-01
HS-GAG biosynthesis	19	1.67e-01	2.29e-01	0.405	-2.41e-02	-7.25e-02	2.07e-01	2.13e-01	-1.29e-01	0.232000	8.55e-01	5.84e-01	1.18e-01	1.08e-01	3.32e-01	8.05e-02
Defects in vitamin and cofactor metabolism	21	1.43e-01	2.02e-01	0.405	-9.95e-02	-1.35e-01	-2.41e-01	1.21e-01	2.49e-01	0.040500	4.30e-01	2.84e-01	5.63e-02	3.36e-01	4.85e-02	7.48e-01
CD209 (DC-SIGN) signaling	20	1.16e-01	1.72e-01	0.405	-3.74e-02	2.94e-01	4.69e-03	1.96e-01	1.95e-01	0.005970	7.72e-01	2.30e-02	9.71e-01	1.30e-01	1.31e-01	9.63e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	1.36e-03	3.95e-03	0.405	-1.22e-01	-1.13e-01	-1.94e-01	2.62e-01	7.53e-02	-0.157000	1.73e-01	2.06e-01	3.00e-02	3.29e-03	3.98e-01	7.84e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	1.06e-02	2.34e-02	0.405	-7.22e-02	2.26e-01	1.82e-01	2.34e-01	5.96e-02	0.127000	5.09e-01	3.87e-02	9.59e-02	3.17e-02	5.85e-01	2.44e-01
Diseases associated with glycosylation precursor biosynthesis	15	2.30e-01	2.99e-01	0.405	-2.91e-02	-3.01e-01	-7.44e-02	2.28e-01	-1.17e-01	-0.031000	8.46e-01	4.36e-02	6.18e-01	1.26e-01	4.33e-01	8.35e-01
HIV Life Cycle	144	9.94e-13	1.15e-11	0.404	-1.60e-01	-2.76e-01	-1.53e-01	1.92e-01	1.62e-02	0.035100	9.48e-04	1.10e-08	1.51e-03	7.05e-05	7.38e-01	4.67e-01
Glycogen breakdown (glycogenolysis)	12	2.77e-01	3.47e-01	0.404	-1.43e-01	4.38e-02	1.47e-01	3.94e-02	-3.07e-01	0.153000	3.91e-01	7.93e-01	3.78e-01	8.13e-01	6.54e-02	3.59e-01
Glyoxylate metabolism and glycine degradation	13	2.37e-01	3.06e-01	0.404	-1.78e-01	-2.57e-01	-3.41e-02	2.38e-01	-8.26e-02	0.029000	2.66e-01	1.08e-01	8.32e-01	1.38e-01	6.06e-01	8.57e-01
Formation of definitive endoderm	8	8.19e-01	8.47e-01	0.404	-2.77e-01	-1.36e-02	8.17e-02	-2.08e-01	-1.87e-01	0.030600	1.75e-01	9.47e-01	6.89e-01	3.07e-01	3.59e-01	8.81e-01
Unfolded Protein Response (UPR)	84	3.28e-08	2.34e-07	0.403	-2.06e-01	-2.45e-01	2.20e-02	1.23e-01	-2.09e-01	0.025700	1.09e-03	1.03e-04	7.28e-01	5.07e-02	9.03e-04	6.83e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	1.75e-03	4.98e-03	0.403	-1.41e-01	-9.01e-02	5.90e-02	3.09e-01	-1.24e-01	0.142000	1.97e-01	4.09e-01	5.89e-01	4.64e-03	2.55e-01	1.92e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	90	2.21e-08	1.63e-07	0.402	-8.96e-02	-2.01e-01	2.33e-02	1.76e-01	-1.18e-01	0.261000	1.42e-01	1.01e-03	7.02e-01	3.95e-03	5.37e-02	1.82e-05
Amplification of signal from the kinetochores	90	2.21e-08	1.63e-07	0.402	-8.96e-02	-2.01e-01	2.33e-02	1.76e-01	-1.18e-01	0.261000	1.42e-01	1.01e-03	7.02e-01	3.95e-03	5.37e-02	1.82e-05
CDC6 association with the ORC:origin complex	8	4.57e-01	5.18e-01	0.402	-3.38e-02	-1.82e-01	-4.82e-02	-2.56e-02	5.21e-02	0.349000	8.69e-01	3.71e-01	8.13e-01	9.00e-01	7.99e-01	8.76e-02
Regulation of TP53 Activity through Methylation	19	3.70e-01	4.35e-01	0.402	-7.89e-02	-1.15e-01	-2.66e-01	1.61e-01	1.75e-01	-0.122000	5.52e-01	3.87e-01	4.48e-02	2.25e-01	1.87e-01	3.56e-01
Acyl chain remodelling of PC	19	1.76e-01	2.40e-01	0.402	-2.11e-01	1.07e-01	2.48e-01	-6.65e-02	-1.80e-02	0.198000	1.11e-01	4.21e-01	6.14e-02	6.16e-01	8.92e-01	1.34e-01
Association of TriC/CCT with target proteins during biosynthesis	35	3.56e-03	9.27e-03	0.402	-2.50e-01	-2.50e-01	-3.50e-02	1.65e-01	-4.55e-02	0.076200	1.04e-02	1.05e-02	7.20e-01	9.13e-02	6.41e-01	4.35e-01
Synaptic adhesion-like molecules	14	5.35e-01	5.90e-01	0.402	1.41e-01	2.86e-01	2.66e-02	1.62e-01	1.32e-01	-0.123000	3.60e-01	6.42e-02	8.63e-01	2.93e-01	3.91e-01	4.27e-01
Hedgehog ‘on’ state	64	3.97e-05	1.71e-04	0.402	-1.53e-01	-2.15e-01	7.96e-02	1.24e-01	-6.58e-02	0.256000	3.46e-02	2.89e-03	2.71e-01	8.57e-02	3.63e-01	4.01e-04
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	2.96e-01	3.66e-01	0.401	-2.87e-01	-1.76e-01	8.68e-03	-1.46e-01	-1.59e-01	-0.023100	1.96e-02	1.54e-01	9.44e-01	2.37e-01	1.97e-01	8.51e-01
G-protein activation	19	2.45e-01	3.14e-01	0.401	-1.21e-01	-1.17e-01	2.37e-01	5.59e-02	-1.69e-01	0.210000	3.62e-01	3.77e-01	7.31e-02	6.73e-01	2.02e-01	1.13e-01
TRAIL signaling	8	2.49e-01	3.19e-01	0.400	-2.45e-01	2.81e-01	-8.58e-02	3.15e-02	5.17e-03	0.113000	2.30e-01	1.69e-01	6.74e-01	8.77e-01	9.80e-01	5.79e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	12	3.09e-01	3.78e-01	0.400	-1.40e-01	-2.88e-01	-2.83e-02	-2.35e-01	1.64e-02	0.030900	4.00e-01	8.37e-02	8.65e-01	1.59e-01	9.22e-01	8.53e-01
Transcriptional regulation by small RNAs	61	3.22e-05	1.41e-04	0.400	-1.57e-01	-2.78e-01	-1.18e-01	2.03e-01	-5.17e-02	-0.013200	3.44e-02	1.73e-04	1.10e-01	6.15e-03	4.85e-01	8.58e-01
Tryptophan catabolism	12	4.55e-01	5.16e-01	0.400	-2.70e-01	-1.50e-01	-1.60e-01	-7.09e-03	1.44e-01	0.135000	1.05e-01	3.70e-01	3.37e-01	9.66e-01	3.89e-01	4.18e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	9	3.22e-01	3.89e-01	0.399	-7.04e-02	-1.11e-01	2.67e-01	2.44e-01	-5.59e-02	0.092200	7.15e-01	5.64e-01	1.65e-01	2.06e-01	7.72e-01	6.32e-01
Defective EXT2 causes exostoses 2	9	3.22e-01	3.89e-01	0.399	-7.04e-02	-1.11e-01	2.67e-01	2.44e-01	-5.59e-02	0.092200	7.15e-01	5.64e-01	1.65e-01	2.06e-01	7.72e-01	6.32e-01
Dopamine Neurotransmitter Release Cycle	18	3.17e-01	3.85e-01	0.399	1.38e-01	2.06e-01	1.11e-01	1.71e-01	2.06e-01	-0.118000	3.12e-01	1.29e-01	4.17e-01	2.09e-01	1.31e-01	3.86e-01
Protein folding	83	2.66e-06	1.42e-05	0.399	-1.56e-01	-2.68e-01	8.05e-02	8.03e-02	-1.50e-01	0.165000	1.42e-02	2.37e-05	2.05e-01	2.06e-01	1.83e-02	9.39e-03
Maturation of nucleoprotein 9694631	15	1.26e-01	1.84e-01	0.398	-1.33e-01	-8.21e-03	7.10e-02	1.60e-01	-1.90e-01	0.272000	3.73e-01	9.56e-01	6.34e-01	2.83e-01	2.02e-01	6.82e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	1.76e-02	3.59e-02	0.398	-5.40e-02	-3.44e-01	3.62e-03	1.37e-01	-8.92e-02	0.101000	6.09e-01	1.10e-03	9.73e-01	1.94e-01	3.98e-01	3.37e-01
Acyl chain remodeling of CL	5	8.15e-01	8.44e-01	0.398	-2.07e-01	1.71e-01	6.92e-02	3.62e-02	3.52e-02	0.281000	4.23e-01	5.07e-01	7.89e-01	8.88e-01	8.92e-01	2.77e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	5.78e-03	1.41e-02	0.398	8.93e-02	-6.38e-02	2.58e-01	9.65e-02	-1.63e-01	0.209000	2.75e-01	4.35e-01	1.58e-03	2.38e-01	4.61e-02	1.07e-02
Late Phase of HIV Life Cycle	131	2.46e-11	2.53e-10	0.397	-1.57e-01	-2.78e-01	-1.32e-01	1.91e-01	-9.20e-03	0.043400	1.89e-03	3.84e-08	9.29e-03	1.64e-04	8.56e-01	3.92e-01
Purine salvage	12	2.96e-01	3.65e-01	0.397	-1.56e-02	-2.09e-01	1.97e-02	1.72e-01	1.79e-01	0.227000	9.26e-01	2.09e-01	9.06e-01	3.03e-01	2.82e-01	1.74e-01
Signaling by ERBB2 ECD mutants	15	2.59e-01	3.29e-01	0.397	-7.16e-02	2.02e-01	2.16e-01	1.39e-01	-6.99e-02	0.201000	6.31e-01	1.76e-01	1.47e-01	3.50e-01	6.39e-01	1.79e-01
PI-3K cascade:FGFR2	13	4.66e-01	5.25e-01	0.397	-6.77e-02	2.45e-01	2.00e-01	-5.57e-02	-9.10e-02	0.202000	6.73e-01	1.26e-01	2.11e-01	7.28e-01	5.70e-01	2.06e-01
RUNX3 Regulates Immune Response and Cell Migration	5	8.39e-01	8.63e-01	0.396	-8.30e-02	3.06e-01	8.57e-02	-1.36e-01	2.11e-02	0.174000	7.48e-01	2.36e-01	7.40e-01	5.98e-01	9.35e-01	5.01e-01
Diseases of carbohydrate metabolism	29	1.48e-01	2.07e-01	0.396	-2.39e-01	-2.33e-01	-1.17e-01	-3.88e-02	-1.27e-01	-0.117000	2.59e-02	2.99e-02	2.77e-01	7.18e-01	2.35e-01	2.74e-01
Metabolism of nitric oxide: NOS3 activation and regulation	13	3.10e-01	3.79e-01	0.395	-4.71e-02	-2.42e-01	-1.00e-01	1.98e-01	-1.20e-02	0.214000	7.69e-01	1.30e-01	5.32e-01	2.16e-01	9.40e-01	1.81e-01
E2F mediated regulation of DNA replication	22	5.81e-02	9.89e-02	0.395	-1.19e-01	-1.85e-01	-6.09e-02	9.77e-02	-4.65e-02	0.304000	3.36e-01	1.34e-01	6.21e-01	4.28e-01	7.06e-01	1.37e-02
ISG15 antiviral mechanism	72	2.86e-07	1.74e-06	0.395	-2.14e-01	-1.43e-01	-1.67e-01	2.10e-01	3.40e-02	0.128000	1.72e-03	3.61e-02	1.43e-02	2.05e-03	6.18e-01	5.98e-02
Macroautophagy	128	2.82e-08	2.05e-07	0.395	-1.76e-01	-2.93e-01	-9.09e-02	3.24e-02	-1.46e-01	0.090000	5.66e-04	1.02e-08	7.57e-02	5.27e-01	4.37e-03	7.88e-02
Killing mechanisms	9	1.52e-01	2.12e-01	0.394	-2.00e-02	-8.57e-02	4.40e-02	7.03e-04	1.89e-01	-0.332000	9.17e-01	6.56e-01	8.19e-01	9.97e-01	3.27e-01	8.48e-02
WNT5:FZD7-mediated leishmania damping	9	1.52e-01	2.12e-01	0.394	-2.00e-02	-8.57e-02	4.40e-02	7.03e-04	1.89e-01	-0.332000	9.17e-01	6.56e-01	8.19e-01	9.97e-01	3.27e-01	8.48e-02
Signaling by ALK fusions and activated point mutants	89	2.66e-06	1.42e-05	0.394	-3.24e-02	9.23e-02	2.16e-01	2.06e-01	3.88e-02	0.235000	5.97e-01	1.32e-01	4.26e-04	8.01e-04	5.27e-01	1.25e-04
Signaling by ALK in cancer	89	2.66e-06	1.42e-05	0.394	-3.24e-02	9.23e-02	2.16e-01	2.06e-01	3.88e-02	0.235000	5.97e-01	1.32e-01	4.26e-04	8.01e-04	5.27e-01	1.25e-04
RAF activation	32	4.09e-02	7.39e-02	0.394	-3.02e-01	-5.39e-02	7.33e-02	-5.86e-02	-6.90e-02	0.218000	3.12e-03	5.97e-01	4.73e-01	5.66e-01	5.00e-01	3.28e-02
Phospholipase C-mediated cascade: FGFR1	8	6.91e-01	7.29e-01	0.393	4.80e-02	4.97e-02	-1.26e-01	-2.02e-01	-1.76e-01	-0.249000	8.14e-01	8.08e-01	5.36e-01	3.24e-01	3.90e-01	2.22e-01
G alpha (z) signalling events	36	2.29e-02	4.49e-02	0.393	-8.79e-02	1.52e-02	2.20e-01	-1.19e-02	-2.82e-01	0.135000	3.62e-01	8.75e-01	2.25e-02	9.01e-01	3.39e-03	1.61e-01
RHOJ GTPase cycle	49	5.89e-04	1.88e-03	0.393	-1.20e-01	-3.18e-02	2.38e-01	4.55e-02	-2.61e-01	0.109000	1.45e-01	7.01e-01	3.91e-03	5.82e-01	1.59e-03	1.89e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	40	1.61e-02	3.36e-02	0.393	-2.32e-01	-2.17e-01	1.16e-01	-2.89e-02	-1.42e-01	0.136000	1.11e-02	1.73e-02	2.04e-01	7.52e-01	1.21e-01	1.36e-01
Signaling by RAS mutants	40	1.61e-02	3.36e-02	0.393	-2.32e-01	-2.17e-01	1.16e-01	-2.89e-02	-1.42e-01	0.136000	1.11e-02	1.73e-02	2.04e-01	7.52e-01	1.21e-01	1.36e-01
Signaling by moderate kinase activity BRAF mutants	40	1.61e-02	3.36e-02	0.393	-2.32e-01	-2.17e-01	1.16e-01	-2.89e-02	-1.42e-01	0.136000	1.11e-02	1.73e-02	2.04e-01	7.52e-01	1.21e-01	1.36e-01
Signaling downstream of RAS mutants	40	1.61e-02	3.36e-02	0.393	-2.32e-01	-2.17e-01	1.16e-01	-2.89e-02	-1.42e-01	0.136000	1.11e-02	1.73e-02	2.04e-01	7.52e-01	1.21e-01	1.36e-01
TRP channels	21	2.87e-01	3.56e-01	0.392	8.15e-02	3.33e-01	1.10e-01	8.03e-02	1.33e-01	0.010900	5.18e-01	8.28e-03	3.83e-01	5.24e-01	2.92e-01	9.31e-01
Diseases of programmed cell death	58	1.72e-04	6.34e-04	0.392	-1.09e-01	-3.58e-01	-2.40e-02	5.54e-02	-9.54e-02	0.021600	1.50e-01	2.34e-06	7.51e-01	4.66e-01	2.09e-01	7.76e-01
Ribavirin ADME	11	2.05e-01	2.72e-01	0.392	-6.14e-03	-3.39e-01	9.75e-02	-4.02e-02	2.53e-02	0.164000	9.72e-01	5.18e-02	5.76e-01	8.17e-01	8.85e-01	3.45e-01
Asparagine N-linked glycosylation	284	5.28e-26	1.15e-24	0.392	-2.00e-01	-1.92e-01	9.51e-02	1.21e-01	-1.25e-01	0.193000	7.12e-09	2.57e-08	5.86e-03	4.72e-04	2.86e-04	2.04e-08
Germ layer formation at gastrulation	9	3.00e-01	3.70e-01	0.391	7.17e-02	3.07e-01	2.16e-02	9.15e-02	-5.73e-02	0.204000	7.10e-01	1.11e-01	9.10e-01	6.34e-01	7.66e-01	2.90e-01
Cargo trafficking to the periciliary membrane	47	4.02e-04	1.34e-03	0.391	-2.68e-01	-5.00e-02	-9.63e-02	4.45e-02	1.71e-01	0.196000	1.50e-03	5.53e-01	2.53e-01	5.98e-01	4.31e-02	1.99e-02
Amine ligand-binding receptors	10	6.15e-01	6.65e-01	0.391	2.88e-02	2.71e-01	1.02e-01	-5.70e-02	2.55e-01	-0.000771	8.75e-01	1.38e-01	5.77e-01	7.55e-01	1.63e-01	9.97e-01
Collagen degradation	41	3.56e-03	9.27e-03	0.391	-6.15e-02	1.62e-01	3.31e-01	-2.30e-02	-6.43e-02	0.092000	4.96e-01	7.26e-02	2.44e-04	7.99e-01	4.76e-01	3.08e-01
Non-integrin membrane-ECM interactions	46	4.30e-03	1.10e-02	0.391	-5.76e-02	-6.37e-02	1.77e-01	-2.12e-01	-2.48e-01	-0.086100	4.99e-01	4.55e-01	3.75e-02	1.30e-02	3.56e-03	3.12e-01
Diseases associated with surfactant metabolism	5	7.67e-01	8.00e-01	0.390	2.79e-01	1.32e-02	1.97e-01	-1.77e-01	-3.72e-02	0.051000	2.79e-01	9.59e-01	4.46e-01	4.92e-01	8.86e-01	8.43e-01
ROS and RNS production in phagocytes	30	1.39e-01	1.99e-01	0.390	-1.34e-01	-8.34e-02	2.31e-01	-6.16e-02	-1.41e-01	0.225000	2.05e-01	4.29e-01	2.85e-02	5.59e-01	1.83e-01	3.31e-02
Hyaluronan uptake and degradation	12	1.01e-01	1.53e-01	0.390	-2.01e-01	-2.25e-01	2.05e-01	3.03e-02	-1.18e-01	-0.065600	2.27e-01	1.78e-01	2.19e-01	8.56e-01	4.81e-01	6.94e-01
Role of second messengers in netrin-1 signaling	6	9.58e-01	9.66e-01	0.390	1.52e-01	2.44e-01	1.03e-01	1.72e-01	1.54e-01	0.073400	5.19e-01	3.01e-01	6.61e-01	4.66e-01	5.14e-01	7.56e-01
Chondroitin sulfate biosynthesis	12	1.75e-01	2.39e-01	0.389	-1.21e-01	2.53e-01	2.24e-01	5.05e-02	-1.42e-01	-0.009710	4.69e-01	1.29e-01	1.79e-01	7.62e-01	3.94e-01	9.54e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	5.46e-01	5.98e-01	0.389	-1.48e-02	7.95e-02	3.52e-01	1.41e-01	-2.30e-02	-0.024500	9.50e-01	7.36e-01	1.35e-01	5.50e-01	9.22e-01	9.17e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	5.46e-01	5.98e-01	0.389	-1.48e-02	7.95e-02	3.52e-01	1.41e-01	-2.30e-02	-0.024500	9.50e-01	7.36e-01	1.35e-01	5.50e-01	9.22e-01	9.17e-01
Loss of Function of SMAD2/3 in Cancer	7	4.29e-01	4.92e-01	0.389	-2.65e-01	6.22e-02	-2.09e-01	1.07e-01	1.43e-02	0.149000	2.25e-01	7.76e-01	3.39e-01	6.24e-01	9.48e-01	4.94e-01
Reversal of alkylation damage by DNA dioxygenases	7	7.40e-01	7.74e-01	0.389	1.95e-02	-2.88e-01	-8.29e-02	2.33e-01	-1.86e-02	-0.078400	9.29e-01	1.87e-01	7.04e-01	2.85e-01	9.32e-01	7.19e-01
Metabolism of porphyrins	22	2.31e-02	4.53e-02	0.388	1.79e-01	-2.34e-01	4.71e-02	2.23e-01	8.81e-02	-0.065200	1.45e-01	5.77e-02	7.02e-01	7.01e-02	4.74e-01	5.96e-01
Metabolic disorders of biological oxidation enzymes	21	2.84e-01	3.53e-01	0.388	-2.09e-01	-2.49e-01	1.12e-02	-1.86e-01	-9.91e-02	-0.012500	9.74e-02	4.78e-02	9.29e-01	1.39e-01	4.32e-01	9.21e-01
DAP12 signaling	28	1.68e-02	3.48e-02	0.388	-3.69e-02	9.88e-02	1.21e-01	2.03e-01	-9.40e-02	0.273000	7.35e-01	3.66e-01	2.66e-01	6.24e-02	3.89e-01	1.24e-02
Defective B3GALTL causes PpS	24	4.84e-02	8.42e-02	0.388	1.32e-01	3.03e-01	1.10e-02	1.30e-01	-8.10e-03	-0.154000	2.62e-01	1.01e-02	9.26e-01	2.70e-01	9.45e-01	1.92e-01
Nuclear Envelope (NE) Reassembly	68	2.39e-05	1.07e-04	0.387	-1.60e-01	-2.81e-01	3.71e-02	1.23e-01	-1.35e-01	0.104000	2.26e-02	6.19e-05	5.97e-01	7.96e-02	5.39e-02	1.40e-01
Platelet homeostasis	69	1.10e-04	4.29e-04	0.387	-1.02e-01	-9.82e-03	2.60e-01	9.56e-02	-8.24e-02	0.236000	1.42e-01	8.88e-01	1.91e-04	1.70e-01	2.37e-01	6.89e-04
FRS-mediated FGFR3 signaling	12	6.49e-01	6.94e-01	0.387	-1.79e-01	4.53e-02	2.20e-01	-6.65e-02	-1.53e-01	0.198000	2.82e-01	7.86e-01	1.87e-01	6.90e-01	3.58e-01	2.36e-01
CD28 dependent PI3K/Akt signaling	22	3.41e-02	6.34e-02	0.387	-6.53e-02	1.09e-01	-1.40e-01	2.47e-01	5.53e-02	-0.223000	5.96e-01	3.78e-01	2.56e-01	4.49e-02	6.53e-01	7.00e-02
Thromboxane signalling through TP receptor	20	1.54e-01	2.14e-01	0.386	-1.19e-01	-1.42e-01	2.36e-01	7.52e-02	-1.81e-01	0.144000	3.59e-01	2.71e-01	6.71e-02	5.60e-01	1.62e-01	2.64e-01
EML4 and NUDC in mitotic spindle formation	106	2.24e-08	1.65e-07	0.386	-6.85e-02	-1.73e-01	7.25e-02	1.41e-01	-1.35e-01	0.267000	2.23e-01	2.09e-03	1.97e-01	1.24e-02	1.65e-02	2.03e-06
VEGFA-VEGFR2 Pathway	92	9.45e-07	5.40e-06	0.386	-1.83e-01	-2.74e-02	2.37e-01	3.10e-02	-8.30e-02	0.225000	2.40e-03	6.50e-01	8.42e-05	6.07e-01	1.69e-01	1.90e-04
Factors involved in megakaryocyte development and platelet production	128	5.86e-08	3.96e-07	0.386	6.66e-02	1.74e-02	2.79e-01	1.57e-01	-5.30e-02	0.197000	1.93e-01	7.34e-01	4.87e-08	2.17e-03	3.01e-01	1.19e-04
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	1.84e-03	5.19e-03	0.385	-2.65e-01	-1.03e-01	2.17e-01	-2.52e-02	-1.39e-01	-0.017800	1.35e-02	3.39e-01	4.28e-02	8.14e-01	1.94e-01	8.69e-01
SARS-CoV-1 Infection	137	1.31e-09	1.13e-08	0.385	-1.58e-01	-3.01e-01	-1.44e-01	8.04e-02	-1.32e-02	0.075300	1.45e-03	1.23e-09	3.59e-03	1.04e-01	7.90e-01	1.28e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	6.68e-01	7.09e-01	0.385	1.58e-01	1.60e-01	-9.38e-02	1.58e-01	2.45e-01	-0.064000	2.73e-01	2.69e-01	5.16e-01	2.75e-01	8.98e-02	6.58e-01
Signalling to RAS	19	3.31e-01	3.98e-01	0.385	-8.35e-02	6.47e-02	2.84e-01	-8.61e-03	-2.25e-03	0.237000	5.29e-01	6.25e-01	3.19e-02	9.48e-01	9.86e-01	7.43e-02
Activation of GABAB receptors	29	7.61e-02	1.23e-01	0.385	-4.23e-02	1.87e-01	2.61e-01	3.61e-02	-1.23e-01	0.162000	6.93e-01	8.09e-02	1.49e-02	7.37e-01	2.50e-01	1.30e-01
GABA B receptor activation	29	7.61e-02	1.23e-01	0.385	-4.23e-02	1.87e-01	2.61e-01	3.61e-02	-1.23e-01	0.162000	6.93e-01	8.09e-02	1.49e-02	7.37e-01	2.50e-01	1.30e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	2.13e-02	4.22e-02	0.384	-3.49e-01	2.35e-03	3.90e-02	-9.74e-02	-1.12e-01	0.048200	7.71e-04	9.82e-01	7.07e-01	3.48e-01	2.82e-01	6.42e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.21e-01	1.78e-01	0.384	-1.98e-01	5.36e-02	-1.89e-01	2.55e-01	1.65e-02	0.067400	2.36e-01	7.48e-01	2.57e-01	1.26e-01	9.21e-01	6.86e-01
FOXO-mediated transcription of cell death genes	16	3.73e-02	6.83e-02	0.384	5.58e-02	3.58e-02	1.34e-01	2.37e-01	-6.18e-02	-0.254000	6.99e-01	8.04e-01	3.52e-01	1.00e-01	6.68e-01	7.84e-02
Metalloprotease DUBs	20	3.21e-01	3.89e-01	0.383	-1.34e-01	-1.73e-01	1.84e-01	-9.69e-02	-1.18e-01	0.204000	3.00e-01	1.80e-01	1.53e-01	4.53e-01	3.60e-01	1.14e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	4.33e-02	7.68e-02	0.383	2.23e-01	-1.14e-01	1.92e-01	8.14e-02	2.00e-01	0.029100	1.35e-01	4.45e-01	1.98e-01	5.85e-01	1.81e-01	8.46e-01
RMTs methylate histone arginines	35	6.55e-03	1.57e-02	0.383	1.92e-02	-2.45e-01	-5.46e-02	2.87e-01	-9.66e-03	-0.037100	8.44e-01	1.23e-02	5.76e-01	3.34e-03	9.21e-01	7.04e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.10e-03	3.23e-03	0.383	-1.01e-01	3.14e-02	2.60e-01	1.59e-01	-1.82e-01	0.096800	2.97e-01	7.45e-01	6.91e-03	9.86e-02	5.86e-02	3.15e-01
Chaperonin-mediated protein folding	77	2.02e-05	9.14e-05	0.383	-1.58e-01	-2.38e-01	1.06e-01	7.61e-02	-1.41e-01	0.167000	1.65e-02	3.04e-04	1.09e-01	2.48e-01	3.24e-02	1.11e-02
Activated point mutants of FGFR2	7	4.84e-01	5.41e-01	0.383	3.48e-01	4.60e-02	-7.90e-03	-9.60e-02	1.04e-01	0.057300	1.11e-01	8.33e-01	9.71e-01	6.60e-01	6.34e-01	7.93e-01
RHOF GTPase cycle	38	5.07e-03	1.26e-02	0.382	-1.86e-01	8.60e-02	2.55e-01	3.98e-02	-8.26e-02	0.175000	4.70e-02	3.59e-01	6.57e-03	6.71e-01	3.79e-01	6.13e-02
Downstream signaling of activated FGFR4	18	1.84e-01	2.49e-01	0.382	-9.83e-02	2.35e-01	2.07e-01	5.55e-02	-7.69e-02	0.172000	4.70e-01	8.44e-02	1.29e-01	6.84e-01	5.72e-01	2.08e-01
Cell recruitment (pro-inflammatory response)	25	5.69e-03	1.40e-02	0.382	-3.05e-01	-1.06e-01	2.22e-02	-9.41e-02	5.45e-02	-0.171000	8.19e-03	3.61e-01	8.48e-01	4.16e-01	6.37e-01	1.39e-01
Purinergic signaling in leishmaniasis infection	25	5.69e-03	1.40e-02	0.382	-3.05e-01	-1.06e-01	2.22e-02	-9.41e-02	5.45e-02	-0.171000	8.19e-03	3.61e-01	8.48e-01	4.16e-01	6.37e-01	1.39e-01
Paracetamol ADME	19	1.50e-02	3.17e-02	0.382	-6.15e-02	-3.35e-01	5.80e-02	1.43e-01	5.70e-02	-0.050700	6.43e-01	1.14e-02	6.62e-01	2.82e-01	6.67e-01	7.02e-01
Fanconi Anemia Pathway	36	3.27e-02	6.13e-02	0.382	-9.03e-02	-1.95e-01	-2.56e-01	1.55e-01	1.00e-01	0.004690	3.48e-01	4.28e-02	7.89e-03	1.09e-01	2.98e-01	9.61e-01
Ca2+ pathway	57	8.30e-04	2.54e-03	0.380	-9.49e-02	1.51e-01	2.33e-01	9.79e-02	-2.56e-02	0.220000	2.15e-01	4.88e-02	2.33e-03	2.01e-01	7.38e-01	4.12e-03
SARS-CoV-2-host interactions	181	1.33e-11	1.40e-10	0.380	-1.75e-01	-2.26e-01	-2.05e-01	1.19e-01	5.24e-02	-0.059500	4.92e-05	1.50e-07	2.02e-06	5.82e-03	2.24e-01	1.67e-01
RHOG GTPase cycle	70	2.01e-05	9.09e-05	0.379	-1.10e-01	-3.09e-02	2.36e-01	1.22e-01	-1.65e-01	0.182000	1.12e-01	6.54e-01	6.26e-04	7.85e-02	1.69e-02	8.57e-03
RHOU GTPase cycle	40	7.68e-03	1.79e-02	0.378	-3.80e-02	2.21e-01	1.65e-01	1.78e-01	3.04e-02	0.181000	6.77e-01	1.55e-02	7.05e-02	5.14e-02	7.39e-01	4.72e-02
RHOB GTPase cycle	64	6.07e-06	3.04e-05	0.378	-3.72e-03	5.84e-02	2.60e-01	2.21e-01	-1.16e-01	0.098500	9.59e-01	4.19e-01	3.20e-04	2.20e-03	1.09e-01	1.73e-01
mTORC1-mediated signalling	24	2.47e-01	3.16e-01	0.378	-2.05e-01	-2.76e-01	-2.68e-02	-9.68e-04	-1.04e-01	0.113000	8.15e-02	1.91e-02	8.20e-01	9.93e-01	3.78e-01	3.37e-01
PKA-mediated phosphorylation of CREB	17	2.81e-01	3.50e-01	0.377	-8.35e-02	1.91e-01	2.31e-01	1.27e-01	1.84e-02	0.170000	5.51e-01	1.72e-01	9.99e-02	3.65e-01	8.95e-01	2.25e-01
Apoptosis	157	8.36e-10	7.39e-09	0.377	-1.88e-01	-2.15e-01	3.26e-02	1.61e-02	-1.14e-01	0.216000	4.97e-05	3.48e-06	4.81e-01	7.27e-01	1.41e-02	3.10e-06
The NLRP3 inflammasome	16	3.07e-02	5.81e-02	0.377	-2.71e-01	-1.12e-02	1.04e-02	5.78e-02	1.73e-01	-0.187000	6.06e-02	9.38e-01	9.43e-01	6.89e-01	2.31e-01	1.95e-01
Viral Infection Pathways	768	2.98e-65	5.72e-63	0.377	-1.36e-01	-2.79e-01	-7.07e-02	1.53e-01	-5.87e-02	0.117000	1.69e-10	9.83e-40	8.58e-04	5.82e-13	5.66e-03	3.66e-08
Autophagy	142	6.08e-09	4.80e-08	0.376	-1.74e-01	-2.73e-01	-6.51e-02	5.72e-02	-1.38e-01	0.101000	3.38e-04	1.91e-08	1.81e-01	2.39e-01	4.60e-03	3.79e-02
Pyruvate metabolism	44	4.96e-03	1.23e-02	0.376	-1.65e-01	-2.31e-01	-6.37e-02	1.01e-01	-6.18e-02	0.206000	5.75e-02	8.01e-03	4.65e-01	2.45e-01	4.78e-01	1.79e-02
Diseases associated with O-glycosylation of proteins	46	1.50e-02	3.17e-02	0.376	1.19e-01	2.60e-01	1.29e-01	1.72e-01	9.46e-02	-0.064300	1.61e-01	2.25e-03	1.29e-01	4.39e-02	2.67e-01	4.51e-01
Interleukin-12 signaling	44	9.85e-03	2.19e-02	0.376	-1.95e-01	-1.17e-01	1.58e-01	3.24e-02	-5.79e-02	0.245000	2.49e-02	1.81e-01	6.94e-02	7.10e-01	5.06e-01	4.92e-03
HuR (ELAVL1) binds and stabilizes mRNA	10	6.06e-01	6.56e-01	0.376	-3.66e-02	-6.56e-02	-1.45e-02	2.59e-01	1.02e-01	0.240000	8.41e-01	7.19e-01	9.37e-01	1.56e-01	5.77e-01	1.88e-01
L1CAM interactions	99	1.17e-05	5.51e-05	0.375	-1.40e-02	-3.77e-02	2.93e-01	1.36e-03	-1.63e-01	0.164000	8.09e-01	5.17e-01	4.83e-07	9.81e-01	5.00e-03	4.83e-03
Integrin signaling	22	3.20e-01	3.87e-01	0.375	-1.85e-01	-1.44e-01	1.35e-01	-5.17e-02	-2.38e-01	0.090800	1.33e-01	2.41e-01	2.73e-01	6.75e-01	5.38e-02	4.61e-01
Meiotic synapsis	43	1.66e-02	3.44e-02	0.374	-1.59e-01	-2.05e-01	7.32e-02	6.43e-02	-1.34e-01	0.213000	7.21e-02	1.97e-02	4.07e-01	4.66e-01	1.28e-01	1.58e-02
Mitotic Spindle Checkpoint	107	3.14e-08	2.25e-07	0.374	-1.10e-01	-2.32e-01	-2.68e-02	1.23e-01	-1.06e-01	0.216000	4.85e-02	3.31e-05	6.33e-01	2.75e-02	5.79e-02	1.14e-04
TP53 Regulates Metabolic Genes	77	2.94e-04	1.02e-03	0.372	-2.23e-01	-2.24e-01	2.94e-02	1.18e-02	-1.41e-01	0.134000	7.14e-04	6.95e-04	6.55e-01	8.58e-01	3.23e-02	4.18e-02
Signaling by NTRK3 (TRKC)	15	6.27e-01	6.75e-01	0.372	6.99e-02	2.15e-01	2.13e-01	1.38e-01	1.17e-01	0.097900	6.39e-01	1.50e-01	1.54e-01	3.56e-01	4.31e-01	5.12e-01
Signaling by BRAF and RAF1 fusions	59	2.46e-03	6.66e-03	0.372	-2.98e-01	-1.49e-01	5.72e-02	-8.23e-02	-9.82e-02	0.089100	7.66e-05	4.79e-02	4.47e-01	2.74e-01	1.92e-01	2.37e-01
Cytosolic sulfonation of small molecules	18	4.20e-01	4.85e-01	0.372	-2.20e-01	-1.66e-01	7.64e-03	-8.19e-02	-2.19e-01	-0.088500	1.06e-01	2.24e-01	9.55e-01	5.48e-01	1.08e-01	5.16e-01
G2/M DNA damage checkpoint	66	2.56e-04	9.03e-04	0.372	-1.32e-01	-2.40e-01	5.51e-02	1.05e-01	-1.15e-01	0.190000	6.41e-02	7.53e-04	4.39e-01	1.40e-01	1.05e-01	7.72e-03
Diseases associated with the TLR signaling cascade	29	1.21e-02	2.65e-02	0.372	-1.80e-01	2.71e-01	1.11e-01	4.12e-02	1.15e-01	0.071400	9.39e-02	1.16e-02	3.00e-01	7.01e-01	2.84e-01	5.05e-01
Diseases of Immune System	29	1.21e-02	2.65e-02	0.372	-1.80e-01	2.71e-01	1.11e-01	4.12e-02	1.15e-01	0.071400	9.39e-02	1.16e-02	3.00e-01	7.01e-01	2.84e-01	5.05e-01
EPHA-mediated growth cone collapse	21	1.48e-01	2.07e-01	0.371	-3.59e-02	2.67e-02	1.43e-01	1.20e-01	-1.89e-01	0.255000	7.76e-01	8.32e-01	2.56e-01	3.42e-01	1.33e-01	4.28e-02
Maturation of nucleoprotein 9683610	11	3.24e-01	3.92e-01	0.371	-1.59e-01	-5.01e-02	3.44e-02	1.93e-01	-1.78e-01	0.199000	3.60e-01	7.74e-01	8.44e-01	2.68e-01	3.07e-01	2.54e-01
RSV-host interactions	76	1.39e-06	7.77e-06	0.371	-5.21e-02	-2.38e-02	-6.06e-02	2.84e-01	8.86e-02	0.204000	4.32e-01	7.20e-01	3.61e-01	1.81e-05	1.82e-01	2.07e-03
Deadenylation of mRNA	22	1.14e-01	1.70e-01	0.371	-2.63e-01	-1.34e-01	-1.24e-01	5.28e-02	-8.39e-02	0.158000	3.25e-02	2.78e-01	3.14e-01	6.68e-01	4.96e-01	1.99e-01
Pyroptosis	24	8.14e-02	1.29e-01	0.370	-1.36e-01	-2.05e-01	-1.91e-02	1.44e-01	1.04e-01	0.212000	2.49e-01	8.18e-02	8.71e-01	2.23e-01	3.80e-01	7.28e-02
Caspase activation via Death Receptors in the presence of ligand	16	2.23e-01	2.91e-01	0.370	-1.43e-01	2.75e-01	-7.04e-02	1.24e-02	1.89e-01	0.012200	3.23e-01	5.69e-02	6.26e-01	9.32e-01	1.91e-01	9.33e-01
WNT mediated activation of DVL	8	4.76e-01	5.34e-01	0.370	8.80e-02	6.04e-02	1.51e-01	2.47e-01	-2.86e-02	-0.202000	6.67e-01	7.67e-01	4.61e-01	2.26e-01	8.89e-01	3.23e-01
Ion transport by P-type ATPases	41	9.51e-02	1.47e-01	0.370	1.04e-01	1.49e-01	1.58e-01	2.26e-01	9.31e-02	0.139000	2.50e-01	9.83e-02	8.06e-02	1.25e-02	3.03e-01	1.24e-01
PKMTs methylate histone lysines	42	3.27e-02	6.12e-02	0.370	5.49e-02	1.59e-01	5.24e-02	2.79e-01	1.64e-01	0.031100	5.38e-01	7.40e-02	5.57e-01	1.79e-03	6.52e-02	7.27e-01
Interleukin-12 family signaling	53	3.24e-03	8.56e-03	0.370	-1.96e-01	-1.15e-01	1.47e-01	4.64e-02	-7.98e-02	0.234000	1.35e-02	1.48e-01	6.44e-02	5.59e-01	3.15e-01	3.16e-03
Deadenylation-dependent mRNA decay	50	3.84e-03	9.87e-03	0.369	-1.70e-01	-2.34e-01	-1.93e-01	5.76e-02	9.88e-03	0.112000	3.81e-02	4.28e-03	1.85e-02	4.81e-01	9.04e-01	1.70e-01
PI Metabolism	78	4.33e-08	3.00e-07	0.369	-1.63e-01	2.46e-01	1.07e-01	1.34e-01	9.15e-02	0.107000	1.28e-02	1.73e-04	1.04e-01	4.07e-02	1.63e-01	1.02e-01
Positive epigenetic regulation of rRNA expression	60	7.08e-04	2.21e-03	0.369	-8.88e-02	-3.15e-01	-6.21e-02	9.88e-02	-1.17e-01	-0.037400	2.34e-01	2.41e-05	4.06e-01	1.86e-01	1.15e-01	6.16e-01
Interleukin-1 signaling	99	6.25e-06	3.12e-05	0.369	-2.30e-01	-1.85e-01	1.16e-01	-5.06e-02	-9.93e-02	0.152000	7.64e-05	1.50e-03	4.62e-02	3.84e-01	8.76e-02	8.99e-03
Membrane Trafficking	573	2.47e-46	1.44e-44	0.369	-1.52e-01	-1.01e-01	1.50e-01	1.26e-01	-1.02e-01	0.232000	4.43e-10	3.51e-05	8.40e-10	2.61e-07	2.87e-05	2.62e-21
RHO GTPases Activate Formins	127	4.13e-09	3.38e-08	0.368	-8.16e-02	-1.87e-01	8.04e-02	1.46e-01	-9.71e-02	0.238000	1.12e-01	2.68e-04	1.18e-01	4.38e-03	5.89e-02	3.60e-06
Sphingolipid catabolism	11	6.61e-01	7.03e-01	0.368	-5.68e-02	-1.20e-01	2.02e-01	-2.04e-01	-1.88e-01	0.013400	7.44e-01	4.89e-01	2.47e-01	2.42e-01	2.79e-01	9.39e-01
TNFR1-induced proapoptotic signaling	24	4.66e-01	5.25e-01	0.368	1.36e-01	2.53e-01	9.75e-02	1.12e-01	1.73e-01	0.017900	2.49e-01	3.17e-02	4.09e-01	3.42e-01	1.41e-01	8.80e-01
TRIF-mediated programmed cell death	9	5.09e-01	5.66e-01	0.367	-2.13e-01	1.94e-01	-1.65e-02	1.35e-01	1.78e-01	0.045800	2.69e-01	3.14e-01	9.32e-01	4.83e-01	3.56e-01	8.12e-01
Mitotic G2-G2/M phases	179	5.42e-14	7.03e-13	0.367	-5.76e-02	-2.42e-01	6.48e-02	1.27e-01	-4.89e-02	0.224000	1.84e-01	2.45e-08	1.35e-01	3.44e-03	2.59e-01	2.23e-07
GPER1 signaling	38	2.26e-02	4.45e-02	0.367	-1.72e-01	-4.76e-02	2.14e-01	4.68e-02	-1.41e-01	0.187000	6.72e-02	6.11e-01	2.25e-02	6.18e-01	1.33e-01	4.57e-02
HCMV Late Events	67	4.52e-05	1.93e-04	0.366	-1.18e-01	-2.82e-01	-3.45e-02	1.69e-01	-1.04e-01	0.007820	9.44e-02	6.37e-05	6.26e-01	1.68e-02	1.42e-01	9.12e-01
Cellular response to chemical stress	178	2.44e-13	2.99e-12	0.366	-1.44e-01	-2.04e-01	1.51e-01	7.59e-02	-1.28e-01	0.164000	9.21e-04	2.60e-06	5.29e-04	8.06e-02	3.27e-03	1.62e-04
DNA Repair	288	5.74e-22	1.12e-20	0.366	-9.96e-02	-2.35e-01	-1.51e-01	1.98e-01	5.66e-02	0.054400	3.63e-03	6.56e-12	9.78e-06	6.82e-09	9.87e-02	1.12e-01
FGFR1 ligand binding and activation	10	7.23e-01	7.59e-01	0.365	2.77e-02	-2.81e-02	-2.09e-01	-1.55e-01	-1.04e-01	-0.232000	8.80e-01	8.78e-01	2.54e-01	3.96e-01	5.69e-01	2.05e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	3.55e-02	6.56e-02	0.365	-1.99e-01	-1.48e-01	1.38e-01	1.22e-02	-3.97e-02	0.226000	3.83e-02	1.24e-01	1.52e-01	8.99e-01	6.80e-01	1.90e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	1.00e-01	1.53e-01	0.365	-1.04e-01	-1.70e-01	5.95e-03	1.39e-01	-2.25e-02	0.272000	3.68e-01	1.41e-01	9.59e-01	2.30e-01	8.46e-01	1.86e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	1.00e-01	1.53e-01	0.365	-1.04e-01	-1.70e-01	5.95e-03	1.39e-01	-2.25e-02	0.272000	3.68e-01	1.41e-01	9.59e-01	2.30e-01	8.46e-01	1.86e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	1.00e-01	1.53e-01	0.365	-1.04e-01	-1.70e-01	5.95e-03	1.39e-01	-2.25e-02	0.272000	3.68e-01	1.41e-01	9.59e-01	2.30e-01	8.46e-01	1.86e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	1.00e-01	1.53e-01	0.365	-1.04e-01	-1.70e-01	5.95e-03	1.39e-01	-2.25e-02	0.272000	3.68e-01	1.41e-01	9.59e-01	2.30e-01	8.46e-01	1.86e-02
Loss of Function of TGFBR1 in Cancer	7	7.55e-01	7.88e-01	0.365	-2.88e-01	-6.29e-02	-1.19e-01	1.12e-02	-5.36e-02	0.169000	1.86e-01	7.73e-01	5.85e-01	9.59e-01	8.06e-01	4.39e-01
Amino acids regulate mTORC1	48	4.42e-03	1.12e-02	0.365	-1.32e-01	-2.52e-01	2.90e-02	5.89e-02	-2.16e-01	-0.024300	1.13e-01	2.49e-03	7.28e-01	4.80e-01	9.49e-03	7.71e-01
TBC/RABGAPs	45	1.16e-04	4.47e-04	0.364	-6.76e-02	1.12e-03	1.16e-01	3.20e-01	-5.32e-02	0.098700	4.33e-01	9.90e-01	1.78e-01	2.07e-04	5.37e-01	2.52e-01
Zinc influx into cells by the SLC39 gene family	9	6.45e-01	6.90e-01	0.364	6.63e-02	6.70e-03	1.92e-01	2.33e-01	-1.71e-01	0.088200	7.30e-01	9.72e-01	3.18e-01	2.26e-01	3.75e-01	6.47e-01
Formation of the cornified envelope	32	1.70e-01	2.33e-01	0.364	-1.18e-02	-4.27e-03	2.30e-01	-1.32e-01	-2.41e-01	0.064900	9.08e-01	9.67e-01	2.44e-02	1.95e-01	1.84e-02	5.25e-01
Respiratory Syncytial Virus Infection Pathway	97	6.15e-09	4.82e-08	0.364	-9.68e-02	-7.53e-02	-2.20e-02	2.49e-01	-3.10e-03	0.235000	9.94e-02	2.00e-01	7.08e-01	2.27e-05	9.58e-01	6.54e-05
SUMOylation of DNA damage response and repair proteins	77	1.50e-05	6.94e-05	0.363	-1.11e-01	-7.01e-02	-1.53e-01	2.69e-01	1.37e-01	-0.010400	9.26e-02	2.87e-01	2.04e-02	4.39e-05	3.76e-02	8.74e-01
Downstream signaling of activated FGFR1	22	1.43e-01	2.03e-01	0.363	-1.09e-01	2.34e-01	1.78e-01	-8.23e-02	-1.28e-01	0.101000	3.74e-01	5.70e-02	1.49e-01	5.04e-01	2.99e-01	4.13e-01
ERBB2 Activates PTK6 Signaling	8	5.17e-01	5.73e-01	0.363	-6.39e-02	1.81e-01	1.29e-01	-1.25e-01	2.37e-02	-0.249000	7.54e-01	3.76e-01	5.27e-01	5.39e-01	9.08e-01	2.22e-01
SUMOylation of DNA methylation proteins	16	1.15e-01	1.71e-01	0.363	-9.63e-02	-1.83e-01	-1.36e-02	2.35e-01	1.63e-01	-0.081600	5.05e-01	2.04e-01	9.25e-01	1.04e-01	2.58e-01	5.72e-01
G2/M Transition	177	1.26e-13	1.57e-12	0.363	-5.61e-02	-2.38e-01	6.55e-02	1.28e-01	-4.02e-02	0.223000	1.98e-01	4.84e-08	1.33e-01	3.23e-03	3.56e-01	3.27e-07
Signaling by MET	65	7.65e-04	2.36e-03	0.363	-1.96e-01	2.06e-02	1.74e-01	-2.25e-02	-1.70e-01	0.182000	6.20e-03	7.74e-01	1.54e-02	7.54e-01	1.79e-02	1.13e-02
M Phase	345	9.84e-26	2.10e-24	0.362	-1.18e-01	-2.23e-01	3.87e-02	1.20e-01	-8.33e-02	0.211000	1.62e-04	1.08e-12	2.17e-01	1.24e-04	7.84e-03	1.48e-11
RAB GEFs exchange GTP for GDP on RABs	88	2.34e-06	1.27e-05	0.362	-1.70e-01	-2.54e-02	1.88e-01	1.10e-01	-7.48e-02	0.220000	5.88e-03	6.81e-01	2.32e-03	7.54e-02	2.25e-01	3.53e-04
MicroRNA (miRNA) biogenesis	24	2.01e-01	2.67e-01	0.362	-1.10e-01	-2.45e-01	-1.69e-01	1.54e-01	-6.35e-02	-0.049400	3.52e-01	3.77e-02	1.51e-01	1.93e-01	5.90e-01	6.75e-01
Maternal to zygotic transition (MZT)	71	5.44e-04	1.74e-03	0.361	-1.26e-01	-1.28e-01	1.30e-01	3.22e-02	-2.47e-01	0.138000	6.70e-02	6.26e-02	5.76e-02	6.39e-01	3.13e-04	4.40e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.32e-01	1.90e-01	0.361	-1.79e-01	-2.31e-01	1.44e-02	1.29e-01	-1.56e-01	0.060100	1.37e-01	5.57e-02	9.05e-01	2.83e-01	1.96e-01	6.18e-01
Retinoid metabolism and transport	23	2.86e-02	5.47e-02	0.360	4.88e-02	6.48e-02	3.29e-01	1.14e-01	3.97e-02	0.014500	6.86e-01	5.91e-01	6.24e-03	3.45e-01	7.42e-01	9.04e-01
Impaired BRCA2 binding to PALB2	24	1.25e-01	1.82e-01	0.360	-1.36e-01	-1.58e-01	-4.62e-03	1.35e-01	-1.82e-02	0.260000	2.49e-01	1.81e-01	9.69e-01	2.52e-01	8.77e-01	2.73e-02
MAP kinase activation	63	3.70e-04	1.25e-03	0.359	-3.03e-01	-4.06e-02	9.67e-02	-7.34e-02	-1.22e-01	0.074900	3.14e-05	5.77e-01	1.85e-01	3.14e-01	9.43e-02	3.04e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	6.89e-01	7.28e-01	0.359	-3.32e-02	1.59e-01	2.05e-01	1.09e-01	5.60e-02	0.214000	8.36e-01	3.22e-01	2.02e-01	4.97e-01	7.27e-01	1.82e-01
Ub-specific processing proteases	153	3.95e-09	3.27e-08	0.359	-1.89e-01	-1.79e-01	5.80e-02	4.23e-02	-9.77e-02	0.215000	5.35e-05	1.34e-04	2.16e-01	3.66e-01	3.70e-02	4.47e-06
Transport of vitamins, nucleosides, and related molecules	31	1.44e-01	2.04e-01	0.359	-1.30e-01	-2.91e-01	-1.28e-01	-6.63e-03	-2.67e-02	-0.101000	2.12e-01	5.08e-03	2.19e-01	9.49e-01	7.97e-01	3.29e-01
Processing of DNA double-strand break ends	69	1.18e-04	4.56e-04	0.358	-7.92e-02	-2.65e-01	1.12e-02	1.47e-01	-7.15e-02	0.157000	2.55e-01	1.39e-04	8.73e-01	3.50e-02	3.05e-01	2.37e-02
Thrombin signalling through proteinase activated receptors (PARs)	27	8.54e-02	1.34e-01	0.358	-1.36e-01	-1.06e-01	2.03e-01	4.00e-02	-2.20e-01	0.084000	2.21e-01	3.40e-01	6.76e-02	7.19e-01	4.77e-02	4.50e-01
Transcriptional regulation by RUNX2	86	1.22e-05	5.72e-05	0.358	-1.45e-01	-2.69e-01	5.81e-02	4.02e-02	-6.05e-02	0.161000	2.03e-02	1.57e-05	3.51e-01	5.19e-01	3.32e-01	9.98e-03
Vasopressin regulates renal water homeostasis via Aquaporins	34	8.24e-02	1.30e-01	0.357	-8.51e-02	4.80e-02	2.32e-01	8.51e-02	-9.74e-02	0.219000	3.90e-01	6.28e-01	1.94e-02	3.91e-01	3.26e-01	2.74e-02
M-decay: degradation of maternal mRNAs by maternally stored factors	41	4.39e-03	1.11e-02	0.357	-2.20e-01	-7.04e-02	4.80e-02	6.72e-02	-2.03e-01	0.162000	1.48e-02	4.35e-01	5.95e-01	4.57e-01	2.46e-02	7.23e-02
Signaling by Insulin receptor	63	9.60e-04	2.89e-03	0.357	-1.89e-01	-3.95e-02	1.91e-01	-4.43e-02	-2.10e-01	0.087700	9.61e-03	5.87e-01	8.77e-03	5.43e-01	3.89e-03	2.29e-01
Transcriptional Regulation by E2F6	34	3.11e-02	5.87e-02	0.357	-2.04e-01	-1.64e-01	-1.48e-01	1.15e-01	4.29e-02	0.147000	3.91e-02	9.71e-02	1.35e-01	2.47e-01	6.65e-01	1.38e-01
NRAGE signals death through JNK	52	5.84e-03	1.42e-02	0.357	8.14e-02	1.48e-01	1.52e-01	2.62e-01	8.42e-02	0.018400	3.10e-01	6.57e-02	5.80e-02	1.10e-03	2.93e-01	8.19e-01
Negative regulation of FGFR2 signaling	24	4.29e-01	4.92e-01	0.356	-1.72e-01	-1.73e-01	6.44e-02	-5.67e-02	-1.87e-01	0.159000	1.44e-01	1.43e-01	5.85e-01	6.31e-01	1.12e-01	1.79e-01
Basigin interactions	21	1.10e-01	1.64e-01	0.356	-4.28e-02	-2.09e-01	4.81e-02	2.30e-01	-1.57e-01	0.039800	7.34e-01	9.68e-02	7.03e-01	6.86e-02	2.12e-01	7.52e-01
The phototransduction cascade	26	3.93e-02	7.17e-02	0.356	4.79e-02	-1.50e-01	-1.12e-01	-1.70e-01	-2.43e-01	0.039400	6.73e-01	1.85e-01	3.21e-01	1.33e-01	3.23e-02	7.28e-01
Signaling by FGFR3	32	7.75e-02	1.24e-01	0.356	-1.91e-01	-1.30e-02	1.42e-01	8.73e-03	-1.80e-01	0.194000	6.20e-02	8.99e-01	1.64e-01	9.32e-01	7.85e-02	5.80e-02
Netrin-1 signaling	34	1.79e-01	2.43e-01	0.355	1.76e-02	5.70e-02	2.44e-01	-1.09e-02	-1.94e-01	0.158000	8.59e-01	5.65e-01	1.37e-02	9.13e-01	5.05e-02	1.10e-01
Meiosis	66	6.31e-04	1.99e-03	0.355	-1.38e-01	-2.24e-01	2.98e-04	9.65e-02	-8.99e-02	0.198000	5.19e-02	1.65e-03	9.97e-01	1.75e-01	2.07e-01	5.51e-03
RND2 GTPase cycle	36	9.78e-03	2.19e-02	0.354	4.34e-03	1.27e-01	1.14e-01	3.03e-01	3.41e-02	0.058700	9.64e-01	1.87e-01	2.35e-01	1.67e-03	7.24e-01	5.42e-01
TCF dependent signaling in response to WNT	150	4.51e-09	3.62e-08	0.354	-4.33e-02	-4.97e-02	1.81e-01	1.59e-01	-7.06e-02	0.241000	3.60e-01	2.94e-01	1.33e-04	7.80e-04	1.36e-01	3.41e-07
Aquaporin-mediated transport	38	9.16e-02	1.42e-01	0.354	-9.37e-02	4.72e-02	2.19e-01	3.50e-03	-1.54e-01	0.206000	3.18e-01	6.15e-01	1.93e-02	9.70e-01	1.01e-01	2.77e-02
IKK complex recruitment mediated by RIP1	23	2.26e-01	2.95e-01	0.354	-2.83e-01	-1.05e-02	4.99e-02	-6.59e-02	-4.61e-02	0.190000	1.89e-02	9.31e-01	6.79e-01	5.84e-01	7.02e-01	1.14e-01
Peptide hormone metabolism	52	6.44e-03	1.55e-02	0.354	-1.78e-01	3.90e-02	1.37e-01	-1.35e-01	4.18e-02	0.230000	2.60e-02	6.27e-01	8.77e-02	9.27e-02	6.02e-01	4.04e-03
Activation of Ca-permeable Kainate Receptor	8	8.40e-01	8.64e-01	0.354	1.21e-01	2.22e-01	1.32e-01	4.93e-02	-3.55e-02	0.200000	5.55e-01	2.77e-01	5.17e-01	8.09e-01	8.62e-01	3.27e-01
Ionotropic activity of kainate receptors	8	8.40e-01	8.64e-01	0.354	1.21e-01	2.22e-01	1.32e-01	4.93e-02	-3.55e-02	0.200000	5.55e-01	2.77e-01	5.17e-01	8.09e-01	8.62e-01	3.27e-01
Retrograde transport at the Trans-Golgi-Network	49	6.16e-04	1.95e-03	0.354	-2.62e-01	-3.20e-02	-3.23e-02	1.01e-01	1.33e-02	0.210000	1.50e-03	6.98e-01	6.96e-01	2.23e-01	8.72e-01	1.11e-02
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	9.57e-04	2.89e-03	0.354	3.42e-02	-2.03e-01	1.25e-01	2.12e-01	-1.22e-01	0.085400	6.76e-01	1.30e-02	1.27e-01	9.53e-03	1.36e-01	2.96e-01
Downstream signaling of activated FGFR2	20	3.78e-01	4.43e-01	0.354	1.01e-02	2.32e-01	1.82e-01	3.95e-02	-4.36e-02	0.185000	9.38e-01	7.21e-02	1.59e-01	7.60e-01	7.36e-01	1.51e-01
Circadian Clock	67	3.26e-08	2.34e-07	0.353	-1.37e-01	1.52e-01	2.00e-01	1.95e-01	6.20e-02	0.018600	5.17e-02	3.11e-02	4.70e-03	5.72e-03	3.80e-01	7.92e-01
Signaling by VEGF	99	3.11e-06	1.64e-05	0.352	-1.73e-01	-5.09e-02	2.10e-01	3.39e-02	-6.18e-02	0.206000	2.99e-03	3.82e-01	3.12e-04	5.61e-01	2.88e-01	3.92e-04
Signaling by EGFR in Cancer	22	8.86e-02	1.38e-01	0.352	-1.65e-01	1.20e-01	2.55e-01	5.28e-02	1.17e-03	0.121000	1.80e-01	3.31e-01	3.87e-02	6.68e-01	9.92e-01	3.26e-01
Signaling by PDGF	48	2.29e-03	6.26e-03	0.351	-1.44e-01	9.35e-02	2.65e-01	2.12e-02	-9.00e-02	0.122000	8.39e-02	2.62e-01	1.49e-03	7.99e-01	2.81e-01	1.45e-01
Metabolism of steroid hormones	20	1.79e-01	2.43e-01	0.351	-6.44e-02	-3.06e-01	-3.11e-02	-1.37e-01	-4.19e-02	-0.061500	6.18e-01	1.79e-02	8.10e-01	2.89e-01	7.46e-01	6.34e-01
RNA Polymerase II Pre-transcription Events	77	6.47e-05	2.65e-04	0.351	-1.79e-01	-2.36e-01	-5.46e-02	1.20e-01	9.82e-03	0.132000	6.60e-03	3.37e-04	4.08e-01	6.79e-02	8.82e-01	4.52e-02
Early SARS-CoV-2 Infection Events	30	8.68e-02	1.36e-01	0.349	-1.38e-01	-1.52e-01	9.05e-02	1.21e-01	-1.97e-02	0.238000	1.92e-01	1.50e-01	3.91e-01	2.50e-01	8.52e-01	2.40e-02
Glucagon-type ligand receptors	19	3.41e-01	4.08e-01	0.349	-2.88e-02	-7.14e-02	1.19e-01	1.75e-01	-9.63e-02	0.248000	8.28e-01	5.90e-01	3.67e-01	1.85e-01	4.67e-01	6.17e-02
Negative regulation of FLT3	15	4.58e-01	5.19e-01	0.349	-2.02e-02	-1.17e-02	1.41e-01	2.47e-01	1.08e-01	0.169000	8.93e-01	9.38e-01	3.43e-01	9.81e-02	4.70e-01	2.57e-01
Beta-catenin independent WNT signaling	124	3.81e-08	2.68e-07	0.349	-1.43e-01	-1.53e-01	1.43e-01	1.04e-01	-8.49e-02	0.198000	6.04e-03	3.27e-03	5.82e-03	4.47e-02	1.03e-01	1.45e-04
HS-GAG degradation	18	4.29e-01	4.92e-01	0.348	-6.68e-02	-4.99e-02	-1.41e-01	3.64e-03	8.17e-03	-0.307000	6.24e-01	7.14e-01	3.01e-01	9.79e-01	9.52e-01	2.39e-02
Aspartate and asparagine metabolism	8	6.34e-01	6.80e-01	0.348	8.34e-03	2.20e-02	-6.46e-02	-3.32e-01	5.83e-02	-0.052600	9.67e-01	9.14e-01	7.52e-01	1.04e-01	7.75e-01	7.97e-01
Transferrin endocytosis and recycling	26	1.09e-01	1.63e-01	0.348	-1.53e-01	-8.85e-02	2.28e-01	-1.54e-02	-1.80e-01	0.071400	1.78e-01	4.35e-01	4.37e-02	8.92e-01	1.11e-01	5.29e-01
Fatty acyl-CoA biosynthesis	35	1.74e-01	2.38e-01	0.348	-1.42e-01	-6.97e-02	1.68e-01	-3.88e-02	-1.02e-01	0.237000	1.47e-01	4.76e-01	8.61e-02	6.91e-01	2.95e-01	1.52e-02
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	1.00e-03	2.99e-03	0.348	-7.14e-02	-4.81e-02	2.10e-01	3.30e-02	-1.36e-01	0.224000	2.55e-01	4.44e-01	8.21e-04	5.99e-01	3.08e-02	3.54e-04
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	1.00e-03	2.99e-03	0.348	-7.14e-02	-4.81e-02	2.10e-01	3.30e-02	-1.36e-01	0.224000	2.55e-01	4.44e-01	8.21e-04	5.99e-01	3.08e-02	3.54e-04
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	1.00e-03	2.99e-03	0.348	-7.14e-02	-4.81e-02	2.10e-01	3.30e-02	-1.36e-01	0.224000	2.55e-01	4.44e-01	8.21e-04	5.99e-01	3.08e-02	3.54e-04
Regulation of pyruvate metabolism	32	8.54e-02	1.34e-01	0.348	-1.21e-01	-1.78e-01	5.53e-02	1.09e-01	-1.26e-01	0.209000	2.35e-01	8.16e-02	5.89e-01	2.84e-01	2.18e-01	4.03e-02
FLT3 Signaling	38	2.51e-03	6.77e-03	0.348	-1.61e-01	7.00e-02	1.99e-01	1.76e-01	-5.82e-03	0.141000	8.68e-02	4.55e-01	3.38e-02	6.10e-02	9.51e-01	1.33e-01
Diseases of DNA repair	50	2.81e-03	7.46e-03	0.347	-7.84e-02	-1.90e-01	-1.92e-01	1.56e-01	6.43e-02	0.116000	3.37e-01	2.04e-02	1.89e-02	5.71e-02	4.31e-01	1.55e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	3.00e-01	3.69e-01	0.347	1.02e-01	7.13e-02	2.83e-01	9.15e-02	-8.28e-02	-0.098500	5.24e-01	6.56e-01	7.71e-02	5.68e-01	6.05e-01	5.39e-01
Signaling by ERBB2 KD Mutants	20	1.78e-01	2.42e-01	0.347	-1.12e-01	2.56e-01	1.88e-01	1.77e-02	6.05e-02	0.055100	3.87e-01	4.76e-02	1.45e-01	8.91e-01	6.39e-01	6.69e-01
G-protein mediated events	43	1.56e-03	4.48e-03	0.347	-1.10e-01	1.87e-01	1.62e-01	1.45e-01	1.53e-01	0.049800	2.14e-01	3.43e-02	6.56e-02	9.95e-02	8.27e-02	5.72e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	3.69e-01	4.34e-01	0.346	-2.95e-01	4.23e-02	-1.14e-01	-5.66e-02	1.23e-01	0.001680	4.14e-02	7.70e-01	4.31e-01	6.95e-01	3.95e-01	9.91e-01
Programmed Cell Death	186	6.25e-10	5.63e-09	0.345	-1.74e-01	-1.76e-01	4.60e-02	2.04e-02	-9.49e-02	0.215000	4.43e-05	3.33e-05	2.80e-01	6.31e-01	2.56e-02	4.41e-07
mRNA decay by 5’ to 3’ exoribonuclease	15	4.38e-01	5.01e-01	0.344	-1.22e-01	-1.96e-01	-6.68e-02	1.04e-01	5.42e-02	0.217000	4.15e-01	1.90e-01	6.54e-01	4.86e-01	7.16e-01	1.46e-01
Infectious disease	948	4.54e-69	1.24e-66	0.344	-1.45e-01	-2.37e-01	-1.18e-02	1.40e-01	-6.60e-02	0.130000	3.31e-14	3.84e-35	5.38e-01	3.00e-13	5.82e-04	1.22e-11
Regulation of FOXO transcriptional activity by acetylation	10	4.98e-01	5.55e-01	0.343	-9.83e-02	1.03e-01	1.30e-01	-2.09e-02	-2.79e-01	-0.047100	5.90e-01	5.71e-01	4.77e-01	9.09e-01	1.26e-01	7.96e-01
Interleukin-1 family signaling	127	3.86e-06	2.00e-05	0.343	-2.04e-01	-1.02e-01	1.47e-01	-4.61e-02	-1.18e-01	0.167000	7.45e-05	4.73e-02	4.14e-03	3.70e-01	2.17e-02	1.14e-03
CTLA4 inhibitory signaling	21	4.47e-02	7.86e-02	0.343	-2.83e-01	1.32e-01	-3.39e-02	5.50e-02	1.19e-03	0.125000	2.45e-02	2.95e-01	7.88e-01	6.62e-01	9.92e-01	3.23e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	3.55e-03	9.27e-03	0.343	-6.55e-02	-2.08e-01	3.42e-02	2.31e-01	-4.07e-02	0.117000	4.42e-01	1.44e-02	6.88e-01	6.77e-03	6.33e-01	1.71e-01
Phase II - Conjugation of compounds	68	5.15e-03	1.28e-02	0.343	-1.84e-01	-2.46e-01	-3.20e-04	-1.21e-01	-7.30e-02	0.056600	8.61e-03	4.60e-04	9.96e-01	8.48e-02	2.98e-01	4.20e-01
Innate Immune System	965	9.07e-65	1.45e-62	0.343	-1.83e-01	-8.13e-02	1.46e-01	6.38e-02	-1.06e-01	0.201000	6.55e-22	1.93e-05	1.43e-14	7.91e-04	2.28e-08	2.92e-26
Mitotic Prophase	96	9.33e-07	5.34e-06	0.343	-2.07e-01	-1.81e-01	2.00e-02	1.38e-01	-7.60e-02	0.130000	4.63e-04	2.19e-03	7.34e-01	1.99e-02	1.98e-01	2.83e-02
Defective Intrinsic Pathway for Apoptosis	24	1.25e-01	1.82e-01	0.342	-1.14e-01	-2.68e-01	-7.74e-04	-6.76e-03	-1.06e-01	-0.144000	3.32e-01	2.30e-02	9.95e-01	9.54e-01	3.67e-01	2.21e-01
Biosynthesis of specialized proresolving mediators (SPMs)	15	3.61e-01	4.27e-01	0.342	1.68e-01	7.57e-02	2.17e-01	-1.75e-01	9.32e-03	0.072200	2.61e-01	6.12e-01	1.45e-01	2.40e-01	9.50e-01	6.29e-01
Metabolism of proteins	1756	2.67e-102	2.56e-99	0.342	-1.77e-01	-2.56e-01	-7.74e-02	6.55e-02	-6.14e-02	0.079700	8.57e-35	3.59e-71	7.50e-08	5.29e-06	1.97e-05	3.06e-08
Cell Cycle, Mitotic	487	2.79e-35	9.73e-34	0.342	-5.93e-02	-1.96e-01	4.33e-02	1.64e-01	-3.58e-02	0.212000	2.51e-02	1.11e-13	1.02e-01	5.60e-10	1.76e-01	1.20e-15
Defensins	8	7.92e-01	8.25e-01	0.342	-2.26e-01	-1.54e-01	6.33e-03	1.74e-02	-1.91e-01	-0.071300	2.69e-01	4.50e-01	9.75e-01	9.32e-01	3.48e-01	7.27e-01
MHC class II antigen presentation	113	1.28e-08	9.81e-08	0.341	-1.27e-01	-2.18e-01	1.12e-01	1.30e-01	-4.62e-02	0.145000	1.94e-02	6.03e-05	3.97e-02	1.69e-02	3.96e-01	7.80e-03
Bile acid and bile salt metabolism	28	7.32e-02	1.19e-01	0.341	-6.41e-02	2.44e-01	8.27e-02	1.14e-01	5.97e-02	0.172000	5.57e-01	2.55e-02	4.49e-01	2.96e-01	5.84e-01	1.16e-01
Gastrulation	73	7.02e-04	2.19e-03	0.341	-1.02e-01	-1.85e-01	1.59e-01	-4.93e-03	-8.17e-02	0.200000	1.33e-01	6.33e-03	1.91e-02	9.42e-01	2.28e-01	3.13e-03
Cellular responses to stress	693	8.69e-45	4.39e-43	0.341	-1.69e-01	-2.72e-01	-2.17e-02	6.65e-02	-7.85e-02	0.052700	3.81e-14	2.77e-34	3.32e-01	2.87e-03	4.32e-04	1.81e-02
Cytoprotection by HMOX1	53	3.40e-05	1.48e-04	0.341	-8.45e-02	-6.06e-02	1.45e-01	2.52e-01	-1.30e-01	0.061700	2.87e-01	4.46e-01	6.85e-02	1.48e-03	1.02e-01	4.37e-01
Signaling by ERBB2 in Cancer	21	1.58e-01	2.19e-01	0.340	-1.54e-01	2.01e-01	2.09e-01	2.64e-03	1.31e-02	0.086600	2.23e-01	1.11e-01	9.75e-02	9.83e-01	9.17e-01	4.92e-01
Acyl chain remodelling of PE	19	5.41e-01	5.95e-01	0.339	-2.54e-01	-7.73e-02	-2.69e-02	-2.05e-01	-3.03e-02	-0.033000	5.54e-02	5.60e-01	8.39e-01	1.22e-01	8.19e-01	8.03e-01
Eicosanoid ligand-binding receptors	13	6.81e-01	7.22e-01	0.339	-2.89e-01	-7.71e-02	2.14e-02	-7.45e-02	-2.62e-02	0.138000	7.14e-02	6.30e-01	8.94e-01	6.42e-01	8.70e-01	3.90e-01
Vitamin D (calciferol) metabolism	10	4.35e-01	4.98e-01	0.338	-8.49e-02	-1.31e-01	4.18e-02	1.60e-01	2.46e-01	0.047900	6.42e-01	4.73e-01	8.19e-01	3.81e-01	1.78e-01	7.93e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	17	5.04e-01	5.61e-01	0.338	-5.39e-02	1.65e-01	9.02e-02	5.46e-02	1.28e-01	0.238000	7.00e-01	2.38e-01	5.20e-01	6.97e-01	3.61e-01	8.89e-02
HDR through Homologous Recombination (HRR)	68	9.63e-04	2.89e-03	0.338	-9.08e-02	-2.42e-01	-1.53e-01	1.28e-01	5.79e-02	0.068100	1.96e-01	5.68e-04	2.88e-02	6.83e-02	4.09e-01	3.32e-01
Cellular responses to mechanical stimuli	82	1.62e-06	8.98e-06	0.338	-1.91e-01	-2.59e-02	2.19e-01	5.25e-02	-1.23e-01	0.105000	2.77e-03	6.85e-01	5.94e-04	4.12e-01	5.45e-02	1.01e-01
Response of endothelial cells to shear stress	82	1.62e-06	8.98e-06	0.338	-1.91e-01	-2.59e-02	2.19e-01	5.25e-02	-1.23e-01	0.105000	2.77e-03	6.85e-01	5.94e-04	4.12e-01	5.45e-02	1.01e-01
Signaling by NTRK2 (TRKB)	20	2.43e-01	3.13e-01	0.338	-1.29e-01	1.16e-01	1.48e-01	9.29e-02	-7.71e-02	0.218000	3.19e-01	3.69e-01	2.50e-01	4.72e-01	5.51e-01	9.15e-02
Semaphorin interactions	56	1.34e-03	3.88e-03	0.338	-6.80e-02	-9.73e-03	2.64e-01	8.61e-02	-1.42e-01	0.110000	3.78e-01	9.00e-01	6.38e-04	2.65e-01	6.67e-02	1.53e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	5.90e-02	1.00e-01	0.338	-2.39e-01	5.08e-02	2.12e-01	-8.32e-02	-4.56e-02	-0.013800	5.80e-02	6.87e-01	9.21e-02	5.09e-01	7.18e-01	9.13e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	2.59e-01	3.29e-01	0.338	5.09e-02	2.24e-01	2.05e-01	8.52e-02	2.86e-03	-0.110000	7.16e-01	1.10e-01	1.44e-01	5.43e-01	9.84e-01	4.32e-01
Regulation of lipid metabolism by PPARalpha	107	1.26e-07	8.18e-07	0.337	-6.45e-02	6.52e-02	1.31e-01	2.45e-01	1.12e-01	0.125000	2.49e-01	2.44e-01	1.95e-02	1.19e-05	4.46e-02	2.50e-02
Sphingolipid metabolism	91	1.60e-03	4.56e-03	0.337	-2.07e-01	-1.47e-01	6.76e-02	-6.56e-02	-1.83e-01	0.082500	6.36e-04	1.51e-02	2.65e-01	2.80e-01	2.55e-03	1.74e-01
DNA Double Strand Break Response	47	3.65e-03	9.50e-03	0.337	-6.84e-02	-2.18e-01	2.89e-02	2.20e-01	-4.52e-02	0.098600	4.17e-01	9.56e-03	7.32e-01	9.04e-03	5.92e-01	2.42e-01
PPARA activates gene expression	105	2.11e-07	1.31e-06	0.336	-6.74e-02	5.18e-02	1.44e-01	2.36e-01	9.95e-02	0.140000	2.33e-01	3.59e-01	1.08e-02	2.89e-05	7.82e-02	1.33e-02
Pre-NOTCH Transcription and Translation	47	4.76e-02	8.32e-02	0.336	-5.42e-02	1.07e-02	2.29e-01	7.77e-02	-9.48e-02	0.206000	5.20e-01	8.99e-01	6.65e-03	3.57e-01	2.61e-01	1.46e-02
PLC beta mediated events	39	7.42e-03	1.74e-02	0.336	-8.08e-02	1.86e-01	1.53e-01	1.38e-01	1.69e-01	0.025400	3.83e-01	4.48e-02	9.72e-02	1.36e-01	6.78e-02	7.84e-01
FGFR1b ligand binding and activation	5	7.02e-01	7.40e-01	0.336	1.29e-01	2.42e-02	-2.79e-01	6.21e-02	-1.04e-01	-0.055000	6.17e-01	9.25e-01	2.80e-01	8.10e-01	6.86e-01	8.31e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	3.50e-01	4.16e-01	0.335	-1.09e-01	-1.16e-01	-1.44e-01	1.17e-01	-2.39e-02	0.228000	4.97e-01	4.67e-01	3.69e-01	4.65e-01	8.81e-01	1.55e-01
Formation of RNA Pol II elongation complex	56	2.23e-03	6.12e-03	0.335	-1.22e-01	-2.30e-01	-5.83e-02	1.82e-01	3.46e-03	0.088700	1.13e-01	2.92e-03	4.50e-01	1.84e-02	9.64e-01	2.51e-01
RNA Polymerase II Transcription Elongation	56	2.23e-03	6.12e-03	0.335	-1.22e-01	-2.30e-01	-5.83e-02	1.82e-01	3.46e-03	0.088700	1.13e-01	2.92e-03	4.50e-01	1.84e-02	9.64e-01	2.51e-01
Cardiac conduction	86	5.38e-03	1.33e-02	0.335	3.60e-02	1.51e-01	2.31e-01	6.29e-02	1.39e-02	0.175000	5.64e-01	1.58e-02	2.12e-04	3.13e-01	8.24e-01	5.14e-03
Intrinsic Pathway for Apoptosis	53	1.39e-02	2.97e-02	0.335	-1.75e-01	-2.25e-01	-9.59e-02	8.65e-02	-1.06e-01	0.050900	2.75e-02	4.52e-03	2.27e-01	2.76e-01	1.83e-01	5.22e-01
Peptide ligand-binding receptors	96	1.76e-05	8.06e-05	0.334	5.11e-02	2.28e-02	2.70e-01	-1.02e-01	-1.60e-01	0.007330	3.87e-01	6.99e-01	5.00e-06	8.49e-02	6.70e-03	9.01e-01
Transcriptional regulation of brown and beige adipocyte differentiation	23	1.12e-01	1.67e-01	0.334	-8.42e-02	1.38e-01	2.69e-02	2.48e-01	1.53e-01	-0.009660	4.84e-01	2.52e-01	8.24e-01	3.95e-02	2.05e-01	9.36e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	23	1.12e-01	1.67e-01	0.334	-8.42e-02	1.38e-01	2.69e-02	2.48e-01	1.53e-01	-0.009660	4.84e-01	2.52e-01	8.24e-01	3.95e-02	2.05e-01	9.36e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	35	2.00e-01	2.66e-01	0.334	-2.73e-01	-1.58e-01	-5.39e-02	-6.94e-02	-6.29e-02	0.023900	5.17e-03	1.06e-01	5.81e-01	4.78e-01	5.19e-01	8.07e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	5.31e-01	5.86e-01	0.334	-1.17e-02	-9.04e-02	1.05e-02	1.58e-01	9.05e-02	0.264000	9.40e-01	5.58e-01	9.46e-01	3.05e-01	5.58e-01	8.70e-02
Class B/2 (Secretin family receptors)	52	6.77e-02	1.11e-01	0.334	7.17e-02	2.15e-01	1.72e-01	1.30e-01	6.25e-02	0.097900	3.71e-01	7.38e-03	3.15e-02	1.04e-01	4.36e-01	2.22e-01
CLEC7A (Dectin-1) signaling	85	3.75e-04	1.26e-03	0.334	-2.10e-01	-1.76e-01	4.86e-02	-2.48e-03	-4.30e-02	0.179000	8.01e-04	5.05e-03	4.39e-01	9.69e-01	4.93e-01	4.44e-03
Homologous DNA Pairing and Strand Exchange	43	1.63e-02	3.40e-02	0.333	-1.27e-01	-1.81e-01	-1.60e-01	1.24e-01	5.17e-02	0.137000	1.50e-01	4.05e-02	6.91e-02	1.60e-01	5.57e-01	1.19e-01
Downstream TCR signaling	89	4.56e-05	1.95e-04	0.333	-1.45e-01	-2.21e-01	-2.56e-02	5.73e-02	7.25e-03	0.193000	1.84e-02	3.04e-04	6.77e-01	3.50e-01	9.06e-01	1.66e-03
Homology Directed Repair	110	3.04e-07	1.83e-06	0.333	-3.14e-02	-2.58e-01	-4.41e-02	1.87e-01	7.22e-03	0.080900	5.69e-01	2.84e-06	4.24e-01	7.23e-04	8.96e-01	1.43e-01
Antiviral mechanism by IFN-stimulated genes	140	5.13e-10	4.64e-09	0.332	-1.76e-01	-1.40e-01	-6.44e-02	1.68e-01	-3.94e-03	0.166000	3.16e-04	4.32e-03	1.89e-01	6.16e-04	9.36e-01	6.88e-04
DNA Double-Strand Break Repair	137	6.19e-09	4.83e-08	0.332	-5.79e-02	-2.23e-01	-6.29e-02	2.08e-01	3.66e-02	0.092300	2.42e-01	6.37e-06	2.04e-01	2.61e-05	4.60e-01	6.23e-02
Regulation of insulin secretion	62	9.39e-03	2.11e-02	0.332	-5.52e-02	1.29e-01	2.59e-01	-1.91e-03	-2.68e-02	0.151000	4.52e-01	7.94e-02	4.21e-04	9.79e-01	7.15e-01	3.95e-02
Cell Cycle	609	2.04e-42	9.53e-41	0.332	-6.30e-02	-2.00e-01	1.52e-02	1.64e-01	-3.05e-02	0.195000	7.95e-03	3.47e-17	5.22e-01	4.53e-12	1.99e-01	1.98e-16
Peroxisomal lipid metabolism	27	2.36e-01	3.05e-01	0.332	-1.83e-01	-2.19e-01	-1.33e-01	-4.11e-02	7.18e-02	0.064300	9.99e-02	4.89e-02	2.33e-01	7.12e-01	5.19e-01	5.63e-01
Aspirin ADME	13	3.25e-01	3.92e-01	0.331	4.32e-02	-8.24e-02	3.06e-01	2.53e-02	-2.00e-02	0.080600	7.87e-01	6.07e-01	5.62e-02	8.75e-01	9.01e-01	6.15e-01
Regulation of localization of FOXO transcription factors	11	5.53e-01	6.06e-01	0.331	-1.93e-01	-1.06e-01	8.00e-02	-5.95e-02	-1.71e-01	-0.148000	2.67e-01	5.44e-01	6.46e-01	7.33e-01	3.27e-01	3.95e-01
RHOH GTPase cycle	33	6.82e-02	1.11e-01	0.331	-2.24e-01	4.74e-02	1.00e-01	-2.56e-02	-1.32e-01	0.170000	2.57e-02	6.38e-01	3.20e-01	7.99e-01	1.90e-01	9.12e-02
Cellular responses to stimuli	774	6.10e-48	3.79e-46	0.331	-1.71e-01	-2.52e-01	7.80e-03	6.08e-02	-8.96e-02	0.068400	5.21e-16	7.16e-33	7.12e-01	4.01e-03	2.24e-05	1.23e-03
EPH-ephrin mediated repulsion of cells	42	3.19e-03	8.46e-03	0.331	-8.49e-02	-8.09e-03	2.65e-02	3.03e-01	3.85e-02	0.088900	3.41e-01	9.28e-01	7.66e-01	6.70e-04	6.66e-01	3.19e-01
Nuclear Events (kinase and transcription factor activation)	54	3.88e-04	1.30e-03	0.331	-2.78e-01	1.08e-01	6.21e-02	-1.08e-01	6.92e-02	0.006340	4.10e-04	1.71e-01	4.30e-01	1.70e-01	3.79e-01	9.36e-01
Keratinization	33	2.36e-01	3.05e-01	0.330	9.85e-03	1.77e-02	2.08e-01	-1.39e-01	-2.11e-01	0.039300	9.22e-01	8.60e-01	3.84e-02	1.67e-01	3.58e-02	6.96e-01
Clathrin-mediated endocytosis	126	4.26e-09	3.45e-08	0.330	-1.90e-01	-1.07e-01	1.13e-01	1.11e-01	-1.45e-01	0.125000	2.34e-04	3.88e-02	2.87e-02	3.15e-02	5.05e-03	1.57e-02
Neddylation	215	1.13e-11	1.20e-10	0.330	-1.62e-01	-2.30e-01	-7.54e-02	7.39e-02	-5.53e-02	0.124000	4.05e-05	6.25e-09	5.68e-02	6.20e-02	1.62e-01	1.71e-03
Processing of Intronless Pre-mRNAs	20	4.23e-01	4.88e-01	0.330	-1.99e-01	-1.60e-01	-1.86e-01	5.57e-02	-7.50e-02	-0.005090	1.24e-01	2.15e-01	1.49e-01	6.66e-01	5.61e-01	9.69e-01
TGF-beta receptor signaling activates SMADs	45	4.46e-02	7.85e-02	0.329	-1.34e-01	-1.07e-01	1.37e-01	6.91e-02	-1.08e-01	0.209000	1.19e-01	2.16e-01	1.12e-01	4.23e-01	2.08e-01	1.52e-02
Signaling by FGFR4	32	1.28e-01	1.86e-01	0.329	-1.89e-01	-2.71e-02	1.15e-01	3.15e-03	-1.79e-01	0.163000	6.46e-02	7.91e-01	2.61e-01	9.75e-01	7.96e-02	1.10e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	2.25e-02	4.43e-02	0.329	-1.40e-01	-1.59e-01	-1.54e-01	9.40e-02	6.05e-02	0.164000	1.25e-01	8.11e-02	9.21e-02	3.04e-01	5.08e-01	7.25e-02
PI5P Regulates TP53 Acetylation	8	3.47e-01	4.14e-01	0.328	-2.05e-01	1.04e-01	1.34e-01	1.53e-01	-1.18e-02	-0.117000	3.15e-01	6.12e-01	5.13e-01	4.55e-01	9.54e-01	5.68e-01
FGFR2c ligand binding and activation	5	9.15e-01	9.29e-01	0.328	1.23e-01	7.90e-02	1.82e-01	-1.81e-01	4.58e-02	0.135000	6.33e-01	7.60e-01	4.81e-01	4.83e-01	8.59e-01	6.01e-01
PKR-mediated signaling	67	1.02e-03	3.04e-03	0.328	-1.39e-01	-1.29e-01	3.45e-02	1.19e-01	-6.81e-02	0.227000	4.87e-02	6.68e-02	6.25e-01	9.13e-02	3.35e-01	1.31e-03
Cyclin D associated events in G1	47	1.97e-02	3.96e-02	0.328	-1.02e-01	-1.42e-01	9.48e-02	2.93e-02	1.68e-02	0.259000	2.27e-01	9.26e-02	2.61e-01	7.29e-01	8.42e-01	2.15e-03
G1 Phase	47	1.97e-02	3.96e-02	0.328	-1.02e-01	-1.42e-01	9.48e-02	2.93e-02	1.68e-02	0.259000	2.27e-01	9.26e-02	2.61e-01	7.29e-01	8.42e-01	2.15e-03
TP53 Regulates Transcription of DNA Repair Genes	61	4.46e-03	1.13e-02	0.328	-9.04e-02	-2.04e-01	-1.58e-01	1.75e-01	3.11e-02	0.027000	2.22e-01	5.76e-03	3.23e-02	1.81e-02	6.74e-01	7.16e-01
SARS-CoV Infections	427	3.01e-30	8.76e-29	0.328	-1.08e-01	-2.06e-01	-2.05e-02	1.88e-01	-4.87e-02	0.122000	1.33e-04	2.71e-13	4.67e-01	2.43e-11	8.47e-02	1.50e-05
Fertilization	12	4.55e-01	5.16e-01	0.327	1.85e-01	-6.11e-02	8.05e-02	1.33e-01	2.04e-01	-0.057500	2.68e-01	7.14e-01	6.29e-01	4.23e-01	2.21e-01	7.30e-01
Notch-HLH transcription pathway	28	6.46e-02	1.07e-01	0.327	3.23e-02	9.18e-02	7.73e-02	2.35e-01	1.44e-01	-0.126000	7.67e-01	4.01e-01	4.79e-01	3.17e-02	1.87e-01	2.49e-01
Interleukin-17 signaling	68	3.38e-04	1.15e-03	0.327	-2.80e-01	-2.65e-02	1.03e-01	-4.56e-02	-1.05e-01	0.066100	6.67e-05	7.05e-01	1.43e-01	5.16e-01	1.34e-01	3.46e-01
HCMV Infection	106	2.13e-06	1.16e-05	0.327	-8.51e-02	-2.55e-01	-2.92e-02	1.57e-01	-8.96e-02	0.034000	1.30e-01	5.81e-06	6.04e-01	5.25e-03	1.11e-01	5.46e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	9.88e-04	2.96e-03	0.327	-1.63e-01	-3.42e-02	1.98e-01	7.12e-02	-1.36e-01	0.128000	3.03e-02	6.49e-01	8.55e-03	3.44e-01	7.10e-02	8.98e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	2.21e-02	4.37e-02	0.327	-1.24e-01	-1.66e-01	-1.65e-01	1.15e-01	5.30e-02	0.143000	1.71e-01	6.53e-02	6.75e-02	2.01e-01	5.57e-01	1.14e-01
Diseases of DNA Double-Strand Break Repair	41	2.21e-02	4.37e-02	0.327	-1.24e-01	-1.66e-01	-1.65e-01	1.15e-01	5.30e-02	0.143000	1.71e-01	6.53e-02	6.75e-02	2.01e-01	5.57e-01	1.14e-01
Mitotic Prometaphase	192	6.07e-12	6.58e-11	0.326	-6.96e-02	-1.37e-01	4.55e-02	1.67e-01	-5.36e-02	0.224000	9.63e-02	1.04e-03	2.77e-01	6.81e-05	2.00e-01	9.08e-08
AURKA Activation by TPX2	72	5.23e-04	1.69e-03	0.326	9.37e-03	-1.22e-01	6.20e-02	2.38e-01	1.93e-02	0.175000	8.91e-01	7.38e-02	3.63e-01	4.90e-04	7.77e-01	1.02e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	2.04e-06	1.11e-05	0.326	-4.87e-02	-2.64e-01	-2.33e-02	1.55e-01	-1.78e-02	0.097000	3.91e-01	3.40e-06	6.81e-01	6.32e-03	7.53e-01	8.73e-02
FGFR2 ligand binding and activation	9	6.26e-01	6.75e-01	0.325	2.60e-01	1.90e-02	-1.75e-01	5.12e-02	3.75e-04	-0.066500	1.76e-01	9.21e-01	3.63e-01	7.90e-01	9.98e-01	7.30e-01
Nonhomologous End-Joining (NHEJ)	40	8.15e-02	1.29e-01	0.325	-1.50e-01	-2.00e-01	2.34e-02	5.55e-02	-8.01e-02	0.182000	1.01e-01	2.89e-02	7.98e-01	5.43e-01	3.81e-01	4.61e-02
Sialic acid metabolism	27	1.85e-01	2.49e-01	0.325	-4.88e-02	6.58e-02	2.28e-01	9.47e-02	9.10e-02	0.172000	6.61e-01	5.54e-01	4.05e-02	3.94e-01	4.13e-01	1.21e-01
Adipogenesis	95	4.37e-05	1.87e-04	0.324	4.97e-03	1.19e-01	1.03e-01	2.50e-01	1.15e-01	0.065200	9.33e-01	4.44e-02	8.37e-02	2.45e-05	5.26e-02	2.72e-01
Transcriptional regulation of white adipocyte differentiation	77	4.94e-04	1.62e-03	0.324	6.34e-03	1.21e-01	1.39e-01	2.37e-01	7.98e-02	0.091000	9.23e-01	6.61e-02	3.46e-02	3.25e-04	2.26e-01	1.68e-01
Nuclear Envelope Breakdown	53	3.69e-04	1.25e-03	0.323	-1.65e-01	-7.60e-02	-6.40e-02	2.57e-01	3.83e-02	0.017500	3.79e-02	3.38e-01	4.20e-01	1.23e-03	6.30e-01	8.25e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.77e-01	2.41e-01	0.323	-6.27e-02	-1.60e-01	3.76e-02	1.68e-01	-1.19e-02	0.212000	5.73e-01	1.50e-01	7.35e-01	1.30e-01	9.14e-01	5.63e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	4.02e-02	7.31e-02	0.323	5.88e-02	-1.90e-01	1.19e-01	2.07e-01	-7.99e-02	-0.039900	5.97e-01	8.78e-02	2.86e-01	6.30e-02	4.72e-01	7.20e-01
Pre-NOTCH Expression and Processing	63	2.57e-03	6.92e-03	0.322	-7.73e-02	5.50e-03	1.98e-01	1.33e-01	-9.98e-02	0.176000	2.89e-01	9.40e-01	6.62e-03	6.86e-02	1.71e-01	1.57e-02
G beta:gamma signalling through PLC beta	17	3.96e-01	4.61e-01	0.322	-2.09e-01	-6.49e-02	1.26e-01	7.89e-02	-1.09e-01	0.147000	1.35e-01	6.43e-01	3.70e-01	5.73e-01	4.37e-01	2.94e-01
Presynaptic function of Kainate receptors	17	3.96e-01	4.61e-01	0.322	-2.09e-01	-6.49e-02	1.26e-01	7.89e-02	-1.09e-01	0.147000	1.35e-01	6.43e-01	3.70e-01	5.73e-01	4.37e-01	2.94e-01
ERKs are inactivated	13	4.46e-01	5.08e-01	0.322	-2.27e-01	-1.62e-01	1.13e-04	6.49e-02	-1.01e-01	-0.106000	1.57e-01	3.12e-01	9.99e-01	6.85e-01	5.28e-01	5.07e-01
GRB2 events in ERBB2 signaling	11	4.11e-01	4.76e-01	0.321	-1.63e-01	1.41e-01	1.97e-01	-9.61e-02	-1.82e-02	-0.092000	3.49e-01	4.17e-01	2.59e-01	5.81e-01	9.17e-01	5.97e-01
Signaling by WNT	236	1.78e-13	2.20e-12	0.321	-9.53e-02	-3.67e-02	1.57e-01	1.35e-01	-7.56e-02	0.210000	1.17e-02	3.31e-01	3.30e-05	3.39e-04	4.54e-02	2.80e-08
Ca-dependent events	29	1.16e-01	1.72e-01	0.321	-7.85e-02	1.69e-01	1.83e-01	1.04e-01	1.18e-01	0.100000	4.64e-01	1.14e-01	8.86e-02	3.34e-01	2.71e-01	3.51e-01
RHOQ GTPase cycle	54	2.17e-03	5.98e-03	0.320	-1.41e-01	-6.33e-03	1.81e-01	2.74e-02	-2.15e-01	0.052600	7.22e-02	9.36e-01	2.13e-02	7.28e-01	6.25e-03	5.04e-01
Plasma lipoprotein clearance	32	1.63e-02	3.40e-02	0.320	-4.11e-02	-1.50e-01	1.98e-02	2.67e-01	4.96e-02	-0.066100	6.87e-01	1.41e-01	8.46e-01	9.03e-03	6.27e-01	5.18e-01
Metabolism of amine-derived hormones	10	5.48e-01	6.00e-01	0.320	2.05e-02	1.18e-01	1.65e-01	-2.01e-01	4.79e-02	-0.136000	9.11e-01	5.19e-01	3.68e-01	2.72e-01	7.93e-01	4.56e-01
Negative regulators of DDX58/IFIH1 signaling	34	4.90e-02	8.50e-02	0.320	-1.61e-01	-1.23e-01	-1.87e-01	9.07e-02	3.39e-02	0.131000	1.05e-01	2.15e-01	5.98e-02	3.60e-01	7.33e-01	1.86e-01
SUMO E3 ligases SUMOylate target proteins	161	1.00e-11	1.07e-10	0.320	-7.59e-02	1.61e-02	-3.58e-03	2.81e-01	1.29e-01	0.018100	9.66e-02	7.24e-01	9.37e-01	7.31e-10	4.60e-03	6.92e-01
Hyaluronan metabolism	15	4.95e-02	8.56e-02	0.320	-4.85e-02	-1.41e-01	1.88e-01	1.40e-01	-2.98e-02	-0.155000	7.45e-01	3.46e-01	2.08e-01	3.47e-01	8.42e-01	2.97e-01
SUMOylation	167	2.65e-12	2.96e-11	0.320	-9.25e-02	7.50e-03	-1.86e-02	2.76e-01	1.26e-01	0.029500	3.91e-02	8.67e-01	6.79e-01	6.99e-10	5.00e-03	5.11e-01
IRF3-mediated induction of type I IFN	12	6.55e-01	6.97e-01	0.318	-1.09e-01	-1.03e-01	-1.77e-01	1.59e-01	-5.37e-02	-0.140000	5.13e-01	5.36e-01	2.88e-01	3.41e-01	7.47e-01	4.03e-01
Transcriptional regulation by RUNX1	170	3.47e-07	2.08e-06	0.318	-2.18e-02	-1.08e-01	1.87e-01	4.72e-02	-1.29e-01	0.189000	6.23e-01	1.56e-02	2.70e-05	2.89e-01	3.66e-03	2.19e-05
PIWI-interacting RNA (piRNA) biogenesis	23	1.84e-01	2.48e-01	0.318	-7.25e-02	-1.36e-01	-1.93e-01	1.26e-01	7.30e-02	0.137000	5.47e-01	2.58e-01	1.09e-01	2.95e-01	5.44e-01	2.54e-01
RHOA GTPase cycle	138	3.24e-09	2.69e-08	0.318	-3.18e-02	3.91e-02	2.11e-01	1.95e-01	-5.37e-02	0.115000	5.19e-01	4.28e-01	1.91e-05	7.88e-05	2.76e-01	1.95e-02
Signaling by Activin	13	4.67e-01	5.26e-01	0.318	-2.80e-01	1.82e-02	-7.99e-02	2.48e-02	-1.75e-02	0.121000	8.01e-02	9.10e-01	6.18e-01	8.77e-01	9.13e-01	4.48e-01
Cellular response to heat stress	92	2.71e-06	1.44e-05	0.317	-8.76e-02	-1.39e-01	-4.98e-02	2.58e-01	6.67e-02	-0.021000	1.46e-01	2.15e-02	4.09e-01	1.93e-05	2.69e-01	7.28e-01
Nitric oxide stimulates guanylate cyclase	15	2.41e-01	3.10e-01	0.317	1.24e-01	-5.43e-02	1.04e-01	1.50e-01	1.34e-02	-0.221000	4.04e-01	7.16e-01	4.86e-01	3.14e-01	9.28e-01	1.39e-01
Estrogen-dependent gene expression	96	1.80e-04	6.59e-04	0.317	-7.48e-02	-1.18e-03	1.91e-01	1.14e-01	-6.22e-03	0.213000	2.05e-01	9.84e-01	1.20e-03	5.36e-02	9.16e-01	3.08e-04
CRMPs in Sema3A signaling	13	3.62e-01	4.28e-01	0.317	-1.47e-01	6.66e-02	1.74e-01	1.84e-01	-3.39e-02	0.096300	3.59e-01	6.78e-01	2.76e-01	2.51e-01	8.32e-01	5.48e-01
CASP8 activity is inhibited	11	6.55e-01	6.97e-01	0.317	-2.37e-02	2.52e-01	-7.66e-02	4.15e-02	1.55e-01	0.068300	8.92e-01	1.47e-01	6.60e-01	8.12e-01	3.73e-01	6.95e-01
Dimerization of procaspase-8	11	6.55e-01	6.97e-01	0.317	-2.37e-02	2.52e-01	-7.66e-02	4.15e-02	1.55e-01	0.068300	8.92e-01	1.47e-01	6.60e-01	8.12e-01	3.73e-01	6.95e-01
Regulation by c-FLIP	11	6.55e-01	6.97e-01	0.317	-2.37e-02	2.52e-01	-7.66e-02	4.15e-02	1.55e-01	0.068300	8.92e-01	1.47e-01	6.60e-01	8.12e-01	3.73e-01	6.95e-01
TP53 Regulates Transcription of Cell Cycle Genes	47	3.50e-02	6.49e-02	0.316	6.97e-02	-1.15e-02	1.46e-01	2.49e-01	1.32e-02	0.108000	4.08e-01	8.92e-01	8.28e-02	3.16e-03	8.76e-01	2.01e-01
RHOD GTPase cycle	49	1.95e-03	5.43e-03	0.316	-1.37e-01	3.44e-02	2.00e-01	1.37e-01	-8.07e-02	0.122000	9.81e-02	6.77e-01	1.55e-02	9.61e-02	3.28e-01	1.40e-01
Nucleotide salvage	21	2.13e-01	2.80e-01	0.316	-7.43e-02	-2.43e-01	5.86e-02	1.31e-01	2.04e-02	0.120000	5.56e-01	5.39e-02	6.42e-01	2.98e-01	8.71e-01	3.42e-01
SARS-CoV-2 Infection	263	3.96e-15	5.64e-14	0.316	-1.73e-01	-2.08e-01	-8.45e-02	1.31e-01	-3.81e-03	0.047000	1.37e-06	6.22e-09	1.84e-02	2.44e-04	9.15e-01	1.89e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	5.96e-03	1.45e-02	0.316	-6.93e-02	-6.16e-02	8.73e-02	1.69e-01	-1.36e-02	-0.234000	5.49e-01	5.94e-01	4.50e-01	1.44e-01	9.06e-01	4.31e-02
Glycogen storage diseases	13	8.28e-01	8.54e-01	0.315	-1.30e-01	-1.90e-01	-8.13e-02	-2.33e-02	-1.98e-01	-0.000743	4.15e-01	2.36e-01	6.12e-01	8.84e-01	2.17e-01	9.96e-01
Regulation of HSF1-mediated heat shock response	78	5.53e-05	2.32e-04	0.315	-1.34e-01	-1.51e-01	-6.37e-02	2.26e-01	5.27e-02	0.019200	4.04e-02	2.08e-02	3.30e-01	5.53e-04	4.21e-01	7.69e-01
Synthesis of PA	31	1.48e-01	2.07e-01	0.314	-2.82e-01	1.01e-02	-9.16e-03	-1.23e-01	3.77e-02	0.051800	6.65e-03	9.22e-01	9.30e-01	2.35e-01	7.17e-01	6.18e-01
Zinc transporters	12	4.80e-01	5.38e-01	0.314	-1.56e-01	-7.71e-02	8.99e-02	2.09e-01	-7.53e-02	0.104000	3.50e-01	6.44e-01	5.90e-01	2.11e-01	6.52e-01	5.34e-01
FRS-mediated FGFR4 signaling	13	8.02e-01	8.34e-01	0.313	-1.04e-01	7.82e-02	2.07e-01	-6.68e-03	-6.95e-02	0.184000	5.16e-01	6.26e-01	1.97e-01	9.67e-01	6.64e-01	2.52e-01
DAG and IP3 signaling	33	1.32e-01	1.90e-01	0.313	-2.08e-02	1.81e-01	1.31e-01	1.61e-01	1.38e-01	0.050200	8.36e-01	7.20e-02	1.92e-01	1.09e-01	1.69e-01	6.18e-01
FRS-mediated FGFR1 signaling	15	6.89e-01	7.28e-01	0.311	-1.45e-01	5.07e-02	9.86e-02	-1.21e-01	-2.12e-01	0.062700	3.30e-01	7.34e-01	5.09e-01	4.19e-01	1.55e-01	6.74e-01
Biosynthesis of DHA-derived SPMs	13	3.71e-01	4.36e-01	0.311	2.23e-01	5.16e-02	1.05e-01	-1.27e-01	1.18e-01	-0.057900	1.64e-01	7.47e-01	5.12e-01	4.29e-01	4.62e-01	7.18e-01
Acyl chain remodelling of PS	14	6.05e-01	6.55e-01	0.311	-1.31e-01	7.80e-02	1.49e-01	-2.26e-01	-1.19e-02	0.008530	3.98e-01	6.13e-01	3.34e-01	1.43e-01	9.38e-01	9.56e-01
IRAK2 mediated activation of TAK1 complex	10	8.99e-01	9.17e-01	0.311	-2.09e-01	-1.52e-01	-7.75e-02	-1.01e-01	-1.74e-02	0.115000	2.54e-01	4.04e-01	6.71e-01	5.80e-01	9.24e-01	5.27e-01
Oncogenic MAPK signaling	75	1.79e-03	5.06e-03	0.311	-2.68e-01	-8.97e-02	6.03e-02	-6.05e-02	-5.38e-02	0.080000	5.94e-05	1.79e-01	3.66e-01	3.65e-01	4.20e-01	2.31e-01
VEGFR2 mediated cell proliferation	18	3.50e-01	4.16e-01	0.311	-1.83e-01	-1.07e-01	1.52e-01	4.70e-02	1.35e-02	0.161000	1.78e-01	4.30e-01	2.65e-01	7.30e-01	9.21e-01	2.38e-01
CaM pathway	27	2.74e-01	3.43e-01	0.310	-1.97e-02	1.73e-01	1.44e-01	1.52e-01	1.30e-01	0.073600	8.60e-01	1.20e-01	1.97e-01	1.73e-01	2.43e-01	5.08e-01
Calmodulin induced events	27	2.74e-01	3.43e-01	0.310	-1.97e-02	1.73e-01	1.44e-01	1.52e-01	1.30e-01	0.073600	8.60e-01	1.20e-01	1.97e-01	1.73e-01	2.43e-01	5.08e-01
DAP12 interactions	39	9.84e-03	2.19e-02	0.310	-4.37e-02	1.49e-01	1.29e-01	1.57e-01	-1.14e-01	0.132000	6.37e-01	1.07e-01	1.64e-01	8.93e-02	2.17e-01	1.53e-01
Formation of WDR5-containing histone-modifying complexes	42	4.75e-02	8.31e-02	0.310	1.36e-02	5.66e-02	-1.27e-01	2.56e-01	9.39e-02	-0.043600	8.79e-01	5.25e-01	1.54e-01	4.07e-03	2.92e-01	6.25e-01
FGFR1c ligand binding and activation	8	9.39e-01	9.49e-01	0.310	1.98e-02	-1.04e-01	-1.37e-01	-1.10e-01	-7.37e-02	-0.220000	9.23e-01	6.10e-01	5.03e-01	5.91e-01	7.18e-01	2.81e-01
Downregulation of TGF-beta receptor signaling	26	3.78e-01	4.42e-01	0.309	-1.76e-01	-1.53e-01	7.21e-02	3.13e-02	-1.17e-01	0.145000	1.21e-01	1.76e-01	5.24e-01	7.83e-01	3.00e-01	2.00e-01
Signaling by Retinoic Acid	29	3.11e-01	3.80e-01	0.309	-3.68e-02	-2.06e-02	-1.03e-01	2.05e-01	2.03e-01	0.005270	7.32e-01	8.47e-01	3.38e-01	5.65e-02	5.87e-02	9.61e-01
RAC2 GTPase cycle	85	8.53e-05	3.39e-04	0.308	-1.17e-01	1.18e-01	2.15e-01	6.55e-02	1.70e-03	0.131000	6.26e-02	5.95e-02	6.29e-04	2.96e-01	9.78e-01	3.70e-02
SHC1 events in ERBB2 signaling	17	3.01e-01	3.70e-01	0.308	-1.99e-01	5.11e-02	2.10e-01	-6.80e-02	-5.97e-02	0.022600	1.56e-01	7.15e-01	1.35e-01	6.27e-01	6.70e-01	8.72e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	8.15e-01	8.45e-01	0.307	-1.93e-01	-8.97e-02	7.29e-02	1.30e-02	-9.44e-02	0.186000	2.46e-01	5.91e-01	6.62e-01	9.38e-01	5.71e-01	2.64e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	6.11e-01	6.60e-01	0.307	-2.74e-01	6.46e-03	-7.06e-02	-8.46e-02	7.60e-02	0.039900	6.64e-02	9.65e-01	6.36e-01	5.71e-01	6.10e-01	7.89e-01
SHC-mediated cascade:FGFR3	10	9.20e-01	9.32e-01	0.306	-1.59e-01	1.24e-02	1.50e-01	-9.42e-02	-1.03e-01	0.163000	3.85e-01	9.46e-01	4.12e-01	6.06e-01	5.74e-01	3.72e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	2.53e-06	1.37e-05	0.306	-2.58e-01	5.11e-02	1.06e-01	-6.16e-02	-2.65e-02	0.093700	3.68e-06	3.59e-01	5.71e-02	2.69e-01	6.34e-01	9.25e-02
Toll Like Receptor TLR6:TLR2 Cascade	108	2.53e-06	1.37e-05	0.306	-2.58e-01	5.11e-02	1.06e-01	-6.16e-02	-2.65e-02	0.093700	3.68e-06	3.59e-01	5.71e-02	2.69e-01	6.34e-01	9.25e-02
Potassium Channels	61	2.58e-02	5.01e-02	0.305	1.12e-01	1.51e-01	2.31e-01	-5.81e-02	-2.67e-02	0.016100	1.29e-01	4.17e-02	1.77e-03	4.32e-01	7.19e-01	8.28e-01
Integration of energy metabolism	87	8.66e-04	2.64e-03	0.305	-7.89e-02	8.34e-02	2.39e-01	2.64e-02	-5.72e-02	0.137000	2.04e-01	1.79e-01	1.17e-04	6.70e-01	3.56e-01	2.69e-02
RET signaling	32	5.86e-02	9.95e-02	0.305	-1.33e-01	1.14e-01	2.29e-01	3.81e-02	-4.14e-02	0.082400	1.94e-01	2.66e-01	2.47e-02	7.09e-01	6.85e-01	4.20e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	107	5.91e-08	3.97e-07	0.305	-2.06e-01	-1.59e-02	-8.18e-02	1.91e-01	8.32e-02	0.012200	2.30e-04	7.76e-01	1.44e-01	6.39e-04	1.37e-01	8.27e-01
Disorders of transmembrane transporters	134	2.96e-07	1.79e-06	0.305	-1.64e-01	-2.04e-01	1.95e-02	1.10e-01	-4.69e-02	0.099600	1.08e-03	4.61e-05	6.97e-01	2.82e-02	3.49e-01	4.65e-02
Impaired BRCA2 binding to RAD51	35	6.56e-02	1.08e-01	0.304	-9.72e-02	-8.83e-02	-1.08e-01	1.61e-01	8.15e-02	0.176000	3.20e-01	3.66e-01	2.71e-01	1.00e-01	4.04e-01	7.11e-02
Toll Like Receptor 2 (TLR2) Cascade	109	3.44e-06	1.80e-05	0.303	-2.51e-01	4.46e-02	1.12e-01	-5.73e-02	-1.81e-02	0.102000	5.78e-06	4.21e-01	4.32e-02	3.01e-01	7.44e-01	6.59e-02
Toll Like Receptor TLR1:TLR2 Cascade	109	3.44e-06	1.80e-05	0.303	-2.51e-01	4.46e-02	1.12e-01	-5.73e-02	-1.81e-02	0.102000	5.78e-06	4.21e-01	4.32e-02	3.01e-01	7.44e-01	6.59e-02
Degradation of the extracellular matrix	92	1.47e-04	5.58e-04	0.303	-6.97e-02	1.14e-01	2.52e-01	-1.73e-02	-6.84e-02	0.073200	2.48e-01	5.90e-02	2.92e-05	7.74e-01	2.57e-01	2.25e-01
Synthesis of bile acids and bile salts	25	1.14e-01	1.70e-01	0.302	-9.94e-02	2.33e-01	2.90e-02	7.44e-02	4.43e-02	0.137000	3.90e-01	4.39e-02	8.02e-01	5.19e-01	7.02e-01	2.36e-01
Vitamin B5 (pantothenate) metabolism	20	4.53e-01	5.16e-01	0.301	6.05e-02	-6.38e-02	9.22e-02	1.73e-01	1.45e-01	0.153000	6.40e-01	6.21e-01	4.75e-01	1.79e-01	2.62e-01	2.35e-01
Receptor-type tyrosine-protein phosphatases	11	6.80e-01	7.21e-01	0.301	-3.52e-02	1.38e-01	6.90e-02	-1.86e-01	2.99e-02	-0.173000	8.40e-01	4.27e-01	6.92e-01	2.84e-01	8.63e-01	3.21e-01
Inositol phosphate metabolism	42	8.30e-03	1.91e-02	0.300	-1.29e-01	9.16e-02	8.06e-02	2.10e-01	9.42e-02	0.075500	1.46e-01	3.04e-01	3.66e-01	1.88e-02	2.91e-01	3.97e-01
Glycosphingolipid metabolism	46	1.19e-01	1.76e-01	0.300	-2.52e-01	-9.12e-02	1.66e-02	-8.54e-02	-1.01e-01	0.020600	3.10e-03	2.85e-01	8.45e-01	3.16e-01	2.34e-01	8.09e-01
Iron uptake and transport	52	6.82e-02	1.11e-01	0.300	-1.97e-01	-1.99e-01	2.26e-02	-3.34e-02	-9.35e-02	0.034100	1.39e-02	1.30e-02	7.78e-01	6.77e-01	2.43e-01	6.71e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	17	5.12e-01	5.68e-01	0.300	2.67e-02	-9.44e-02	4.44e-02	8.79e-02	5.89e-02	0.259000	8.49e-01	5.00e-01	7.51e-01	5.31e-01	6.74e-01	6.44e-02
Ion homeostasis	40	1.27e-01	1.85e-01	0.300	3.29e-03	4.08e-02	1.65e-01	1.91e-01	4.97e-02	0.148000	9.71e-01	6.55e-01	7.01e-02	3.67e-02	5.86e-01	1.06e-01
Protein-protein interactions at synapses	53	4.18e-02	7.49e-02	0.300	4.34e-02	2.09e-01	4.47e-02	3.95e-02	1.65e-01	-0.116000	5.85e-01	8.59e-03	5.74e-01	6.19e-01	3.74e-02	1.44e-01
Bacterial Infection Pathways	64	1.03e-03	3.05e-03	0.299	-1.95e-01	-6.86e-02	1.42e-01	8.05e-02	-7.19e-02	0.123000	7.12e-03	3.43e-01	4.90e-02	2.66e-01	3.20e-01	8.99e-02
RND3 GTPase cycle	35	1.28e-01	1.86e-01	0.299	-6.63e-02	1.04e-01	1.86e-01	1.13e-01	-5.86e-02	0.153000	4.97e-01	2.86e-01	5.68e-02	2.48e-01	5.48e-01	1.18e-01
Signaling by NOTCH	173	7.69e-09	5.93e-08	0.298	-9.71e-02	-1.30e-01	1.29e-01	1.20e-01	-6.64e-02	0.165000	2.76e-02	3.18e-03	3.32e-03	6.58e-03	1.32e-01	1.80e-04
Rab regulation of trafficking	121	3.98e-07	2.37e-06	0.298	-1.13e-01	-2.28e-02	1.44e-01	1.66e-01	-5.24e-02	0.157000	3.24e-02	6.64e-01	6.37e-03	1.57e-03	3.20e-01	2.88e-03
Synthesis of IP3 and IP4 in the cytosol	22	3.50e-02	6.49e-02	0.298	-1.47e-01	1.33e-01	1.02e-01	1.75e-01	3.14e-02	-0.086800	2.32e-01	2.80e-01	4.07e-01	1.56e-01	7.99e-01	4.81e-01
Defects in cobalamin (B12) metabolism	13	6.31e-01	6.78e-01	0.297	-2.07e-02	-7.24e-02	-6.14e-02	8.92e-02	1.75e-01	0.201000	8.97e-01	6.51e-01	7.02e-01	5.77e-01	2.74e-01	2.10e-01
Toll-like Receptor Cascades	162	6.97e-10	6.25e-09	0.297	-2.20e-01	5.73e-02	1.20e-01	1.49e-02	3.72e-02	0.143000	1.33e-06	2.08e-01	8.21e-03	7.43e-01	4.14e-01	1.71e-03
TICAM1-dependent activation of IRF3/IRF7	13	8.07e-01	8.38e-01	0.297	1.76e-01	3.61e-02	-4.37e-02	1.11e-01	1.97e-01	0.053700	2.73e-01	8.22e-01	7.85e-01	4.88e-01	2.19e-01	7.37e-01
HDACs deacetylate histones	45	7.82e-03	1.82e-02	0.296	-3.38e-02	-1.57e-01	9.52e-02	2.20e-01	1.77e-02	0.066800	6.95e-01	6.85e-02	2.69e-01	1.08e-02	8.37e-01	4.38e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	2.04e-04	7.37e-04	0.296	-1.37e-01	1.27e-01	2.06e-01	-4.01e-02	-6.60e-02	0.066700	2.97e-02	4.35e-02	1.13e-03	5.26e-01	2.96e-01	2.90e-01
Collagen chain trimerization	26	5.82e-01	6.33e-01	0.296	2.59e-02	1.99e-01	1.72e-01	2.25e-02	6.26e-02	0.117000	8.19e-01	7.98e-02	1.29e-01	8.43e-01	5.81e-01	3.04e-01
Cell-cell junction organization	55	6.89e-02	1.12e-01	0.296	3.58e-02	2.30e-01	4.96e-02	7.50e-02	1.53e-01	-0.044500	6.46e-01	3.14e-03	5.25e-01	3.36e-01	5.03e-02	5.68e-01
Gene Silencing by RNA	87	4.85e-04	1.59e-03	0.296	-1.56e-01	-1.69e-01	-1.10e-01	1.41e-01	-1.84e-02	0.049600	1.19e-02	6.37e-03	7.66e-02	2.33e-02	7.67e-01	4.24e-01
Hedgehog ‘off’ state	90	1.31e-03	3.81e-03	0.296	-1.18e-01	-1.72e-01	7.50e-02	3.45e-02	-4.46e-02	0.188000	5.39e-02	4.72e-03	2.19e-01	5.72e-01	4.65e-01	2.08e-03
Interferon Signaling	237	2.75e-13	3.34e-12	0.296	-1.11e-01	-1.00e-01	-6.82e-02	1.78e-01	7.55e-02	0.152000	3.21e-03	7.87e-03	7.06e-02	2.29e-06	4.54e-02	5.85e-05
TNFR2 non-canonical NF-kB pathway	83	9.46e-05	3.74e-04	0.295	-5.25e-02	-2.40e-01	4.93e-03	-4.37e-03	2.30e-02	0.162000	4.08e-01	1.58e-04	9.38e-01	9.45e-01	7.17e-01	1.06e-02
ESR-mediated signaling	157	1.46e-07	9.33e-07	0.295	-1.38e-01	-2.71e-02	1.79e-01	6.26e-02	-5.27e-02	0.170000	2.86e-03	5.58e-01	1.12e-04	1.76e-01	2.54e-01	2.43e-04
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	5.60e-01	6.12e-01	0.295	-1.39e-01	-1.03e-02	1.09e-01	8.62e-02	-7.18e-02	0.207000	3.06e-01	9.40e-01	4.21e-01	5.27e-01	5.98e-01	1.29e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	5.60e-01	6.12e-01	0.295	-1.39e-01	-1.03e-02	1.09e-01	8.62e-02	-7.18e-02	0.207000	3.06e-01	9.40e-01	4.21e-01	5.27e-01	5.98e-01	1.29e-01
Sensing of DNA Double Strand Breaks	6	9.45e-01	9.53e-01	0.294	-8.28e-02	8.78e-02	-1.08e-01	8.98e-02	2.04e-01	0.103000	7.25e-01	7.09e-01	6.47e-01	7.03e-01	3.86e-01	6.61e-01
Activation of BH3-only proteins	29	2.86e-01	3.55e-01	0.294	-1.36e-01	-1.58e-01	-1.02e-01	6.76e-02	-1.02e-01	-0.133000	2.05e-01	1.40e-01	3.40e-01	5.29e-01	3.43e-01	2.15e-01
Glutamate and glutamine metabolism	12	9.24e-01	9.35e-01	0.294	-1.51e-01	-2.12e-01	-2.73e-02	-6.69e-02	-1.12e-01	0.024200	3.65e-01	2.03e-01	8.70e-01	6.88e-01	5.01e-01	8.84e-01
Oxidative Stress Induced Senescence	77	5.77e-03	1.41e-02	0.293	-1.57e-01	-1.20e-01	1.28e-01	1.21e-02	-7.25e-02	0.159000	1.72e-02	6.76e-02	5.30e-02	8.55e-01	2.72e-01	1.59e-02
Regulation of TP53 Activity through Phosphorylation	88	1.14e-03	3.34e-03	0.293	-1.78e-01	-1.76e-01	-4.96e-02	8.51e-02	-2.80e-02	0.113000	3.96e-03	4.34e-03	4.21e-01	1.68e-01	6.50e-01	6.65e-02
NCAM1 interactions	26	2.28e-01	2.96e-01	0.293	-5.86e-02	2.29e-01	-3.93e-02	-3.02e-02	8.26e-02	-0.144000	6.05e-01	4.37e-02	7.29e-01	7.90e-01	4.66e-01	2.03e-01
Blood group systems biosynthesis	16	6.85e-01	7.25e-01	0.293	-5.37e-02	1.85e-02	-1.59e-01	-1.36e-01	-1.03e-01	-0.167000	7.10e-01	8.98e-01	2.70e-01	3.46e-01	4.77e-01	2.47e-01
G beta:gamma signalling through PI3Kgamma	22	2.84e-01	3.53e-01	0.290	-1.78e-01	-9.64e-03	1.18e-01	8.28e-02	-1.29e-01	0.123000	1.48e-01	9.38e-01	3.40e-01	5.01e-01	2.96e-01	3.16e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	2.73e-02	5.25e-02	0.290	-7.61e-03	1.97e-01	2.11e-01	2.39e-03	-2.41e-03	0.034800	9.21e-01	1.02e-02	5.97e-03	9.75e-01	9.75e-01	6.50e-01
Cell-Cell communication	107	1.93e-03	5.40e-03	0.290	3.44e-03	1.45e-01	1.64e-01	1.21e-01	5.67e-02	0.135000	9.51e-01	9.46e-03	3.41e-03	3.04e-02	3.11e-01	1.56e-02
Alpha-protein kinase 1 signaling pathway	11	8.32e-01	8.58e-01	0.289	-9.83e-02	-4.13e-02	5.78e-02	-1.84e-01	-8.01e-03	0.187000	5.73e-01	8.13e-01	7.40e-01	2.90e-01	9.63e-01	2.82e-01
Muscle contraction	140	7.27e-04	2.25e-03	0.289	-6.57e-04	6.67e-02	2.20e-01	2.11e-02	-5.20e-02	0.167000	9.89e-01	1.73e-01	7.12e-06	6.67e-01	2.88e-01	6.63e-04
Regulation of PLK1 Activity at G2/M Transition	87	6.82e-04	2.14e-03	0.289	-3.72e-02	-1.20e-01	2.35e-02	1.85e-01	3.68e-02	0.178000	5.48e-01	5.27e-02	7.05e-01	2.89e-03	5.52e-01	4.13e-03
Phospholipase C-mediated cascade; FGFR4	6	9.71e-01	9.76e-01	0.289	2.01e-01	1.09e-01	3.28e-02	1.80e-02	1.45e-01	-0.091600	3.93e-01	6.45e-01	8.89e-01	9.39e-01	5.39e-01	6.97e-01
AKT phosphorylates targets in the cytosol	14	1.53e-01	2.13e-01	0.288	-3.31e-02	-5.02e-02	1.61e-01	1.53e-01	-1.74e-02	-0.173000	8.30e-01	7.45e-01	2.98e-01	3.20e-01	9.10e-01	2.63e-01
Opioid Signalling	74	4.73e-04	1.56e-03	0.288	-1.43e-01	5.36e-02	1.80e-01	9.57e-02	-7.69e-03	0.133000	3.31e-02	4.25e-01	7.33e-03	1.55e-01	9.09e-01	4.72e-02
HDR through Single Strand Annealing (SSA)	37	1.10e-01	1.64e-01	0.288	-1.04e-01	-9.17e-02	-1.17e-01	1.65e-01	9.36e-02	0.117000	2.73e-01	3.34e-01	2.16e-01	8.20e-02	3.25e-01	2.17e-01
FRS-mediated FGFR2 signaling	15	8.81e-01	9.02e-01	0.287	4.11e-02	9.55e-02	1.73e-01	-1.97e-02	-2.62e-02	0.200000	7.83e-01	5.22e-01	2.45e-01	8.95e-01	8.61e-01	1.79e-01
TCR signaling	110	9.44e-05	3.74e-04	0.286	-1.08e-01	-1.36e-01	1.56e-02	7.28e-02	2.46e-02	0.214000	4.95e-02	1.41e-02	7.77e-01	1.87e-01	6.56e-01	1.09e-04
Loss of Nlp from mitotic centrosomes	69	5.39e-03	1.33e-02	0.286	-1.28e-02	-1.14e-01	3.79e-02	2.14e-01	2.66e-02	0.145000	8.55e-01	1.03e-01	5.86e-01	2.16e-03	7.03e-01	3.73e-02
Loss of proteins required for interphase microtubule organization from the centrosome	69	5.39e-03	1.33e-02	0.286	-1.28e-02	-1.14e-01	3.79e-02	2.14e-01	2.66e-02	0.145000	8.55e-01	1.03e-01	5.86e-01	2.16e-03	7.03e-01	3.73e-02
STING mediated induction of host immune responses	15	6.05e-01	6.55e-01	0.286	-5.40e-02	-2.91e-02	-1.12e-01	2.43e-01	5.06e-02	-0.059400	7.17e-01	8.45e-01	4.51e-01	1.03e-01	7.34e-01	6.91e-01
G alpha (12/13) signalling events	68	1.74e-02	3.55e-02	0.286	3.05e-02	8.38e-02	1.87e-01	1.70e-01	4.55e-03	0.099100	6.63e-01	2.32e-01	7.74e-03	1.51e-02	9.48e-01	1.58e-01
RAC1 GTPase cycle	170	2.00e-09	1.69e-08	0.286	-6.59e-02	1.48e-01	1.88e-01	1.15e-01	2.01e-02	0.079400	1.38e-01	8.96e-04	2.24e-05	9.91e-03	6.52e-01	7.40e-02
Caspase activation via extrinsic apoptotic signalling pathway	25	4.71e-01	5.29e-01	0.285	-6.11e-02	1.65e-01	9.01e-02	6.62e-02	1.24e-01	0.150000	5.97e-01	1.53e-01	4.36e-01	5.67e-01	2.82e-01	1.96e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	619	6.16e-30	1.74e-28	0.285	-9.17e-02	-3.04e-02	1.62e-01	1.09e-01	-7.47e-02	0.168000	9.93e-05	1.97e-01	5.79e-12	3.47e-06	1.53e-03	1.10e-12
HCMV Early Events	84	1.09e-03	3.23e-03	0.285	-6.69e-02	-2.24e-01	-4.09e-02	1.39e-01	-7.29e-02	-0.011800	2.89e-01	3.76e-04	5.17e-01	2.82e-02	2.48e-01	8.52e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	5.75e-02	9.82e-02	0.285	-3.50e-02	2.26e-01	1.41e-01	6.76e-02	-4.56e-02	0.045900	7.09e-01	1.58e-02	1.32e-01	4.71e-01	6.26e-01	6.24e-01
FOXO-mediated transcription of cell cycle genes	14	5.42e-01	5.95e-01	0.285	-2.37e-01	1.09e-01	7.39e-02	-5.79e-02	-6.24e-02	0.017400	1.25e-01	4.80e-01	6.32e-01	7.07e-01	6.86e-01	9.10e-01
SARS-CoV-1 activates/modulates innate immune responses	40	9.91e-02	1.52e-01	0.284	-9.26e-02	-6.29e-02	-5.15e-02	1.88e-01	1.59e-01	0.070200	3.11e-01	4.91e-01	5.73e-01	3.93e-02	8.14e-02	4.42e-01
HATs acetylate histones	92	6.15e-05	2.53e-04	0.284	-1.18e-01	-1.61e-01	-2.28e-02	1.41e-01	-1.42e-01	-0.016400	5.06e-02	7.45e-03	7.06e-01	1.98e-02	1.84e-02	7.86e-01
G alpha (s) signalling events	93	7.96e-04	2.44e-03	0.284	-3.05e-02	7.94e-02	1.74e-01	1.59e-01	4.15e-02	0.127000	6.12e-01	1.86e-01	3.77e-03	7.91e-03	4.89e-01	3.50e-02
Class I MHC mediated antigen processing & presentation	343	5.41e-15	7.57e-14	0.284	-1.76e-01	-1.27e-01	-1.41e-02	4.97e-02	-7.34e-02	0.159000	2.25e-08	5.13e-05	6.53e-01	1.14e-01	1.96e-02	4.10e-07
Signaling by Rho GTPases	603	2.67e-28	7.01e-27	0.283	-8.66e-02	-2.32e-02	1.63e-01	1.10e-01	-6.86e-02	0.170000	2.81e-04	3.30e-01	7.85e-12	4.40e-06	4.02e-03	9.93e-13
Toll Like Receptor 4 (TLR4) Cascade	138	4.39e-07	2.59e-06	0.283	-2.00e-01	7.81e-02	1.33e-01	-1.26e-02	1.36e-02	0.127000	5.06e-05	1.13e-01	7.16e-03	7.99e-01	7.83e-01	9.78e-03
Signaling by NTRK1 (TRKA)	102	6.04e-06	3.03e-05	0.283	-2.30e-01	4.84e-02	1.34e-01	-2.25e-02	-2.01e-02	0.076300	5.91e-05	3.99e-01	1.90e-02	6.95e-01	7.26e-01	1.83e-01
Uptake and actions of bacterial toxins	26	9.23e-02	1.43e-01	0.283	-8.59e-02	4.23e-02	2.39e-01	2.40e-02	8.53e-02	0.076000	4.49e-01	7.09e-01	3.48e-02	8.33e-01	4.52e-01	5.02e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	8.34e-01	8.59e-01	0.283	-2.28e-01	-7.71e-03	-9.71e-02	-1.47e-02	-1.21e-01	0.060000	2.64e-01	9.70e-01	6.35e-01	9.43e-01	5.53e-01	7.69e-01
Transport of bile salts and organic acids, metal ions and amine compounds	51	8.60e-02	1.35e-01	0.282	-6.39e-02	3.51e-02	1.93e-01	-3.06e-02	-1.79e-01	0.060800	4.30e-01	6.65e-01	1.70e-02	7.05e-01	2.72e-02	4.52e-01
Signaling by ERBB2 TMD/JMD mutants	17	4.53e-01	5.16e-01	0.281	-7.17e-02	1.70e-01	1.63e-01	3.62e-02	1.32e-01	0.008610	6.09e-01	2.26e-01	2.46e-01	7.96e-01	3.46e-01	9.51e-01
Cargo recognition for clathrin-mediated endocytosis	87	3.06e-03	8.13e-03	0.281	-2.06e-01	-1.36e-01	1.88e-02	2.26e-02	-1.20e-01	0.054500	9.13e-04	2.89e-02	7.62e-01	7.16e-01	5.34e-02	3.80e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	9.15e-01	9.29e-01	0.281	-2.16e-01	-9.31e-02	-5.04e-02	-1.06e-01	1.47e-03	0.097100	2.14e-01	5.93e-01	7.72e-01	5.43e-01	9.93e-01	5.77e-01
Chromatin modifying enzymes	213	7.62e-13	9.09e-12	0.280	-1.76e-02	4.94e-02	4.22e-02	2.67e-01	4.86e-02	0.005230	6.57e-01	2.14e-01	2.89e-01	1.75e-11	2.22e-01	8.95e-01
Chromatin organization	213	7.62e-13	9.09e-12	0.280	-1.76e-02	4.94e-02	4.22e-02	2.67e-01	4.86e-02	0.005230	6.57e-01	2.14e-01	2.89e-01	1.75e-11	2.22e-01	8.95e-01
Negative regulation of the PI3K/AKT network	91	2.06e-04	7.42e-04	0.280	-1.30e-01	1.26e-01	1.92e-01	-3.70e-02	-6.41e-02	0.053500	3.23e-02	3.72e-02	1.53e-03	5.42e-01	2.91e-01	3.77e-01
Signaling by Interleukins	385	2.07e-15	3.06e-14	0.279	-9.38e-02	5.02e-02	2.07e-01	1.25e-02	-3.47e-02	0.150000	1.59e-03	9.12e-02	3.02e-12	6.73e-01	2.42e-01	4.22e-07
Signaling by TGFB family members	137	6.61e-07	3.81e-06	0.279	-1.38e-01	5.44e-02	1.31e-01	1.09e-01	-2.23e-02	0.162000	5.29e-03	2.72e-01	8.01e-03	2.80e-02	6.52e-01	1.06e-03
Intra-Golgi traffic	43	1.37e-02	2.94e-02	0.279	-2.21e-01	-2.79e-02	4.52e-02	1.18e-01	-6.04e-02	0.093300	1.23e-02	7.51e-01	6.08e-01	1.80e-01	4.93e-01	2.90e-01
Extra-nuclear estrogen signaling	65	1.48e-02	3.14e-02	0.278	-1.77e-01	-9.39e-03	1.65e-01	-3.36e-02	-9.02e-02	0.098500	1.38e-02	8.96e-01	2.12e-02	6.40e-01	2.09e-01	1.69e-01
Arachidonate metabolism	42	8.72e-02	1.36e-01	0.277	-6.20e-02	-4.28e-02	1.23e-01	-2.30e-01	-5.49e-02	0.009620	4.87e-01	6.31e-01	1.66e-01	9.88e-03	5.38e-01	9.14e-01
RUNX2 regulates bone development	21	5.44e-01	5.97e-01	0.277	-1.24e-01	4.67e-02	1.69e-01	4.68e-02	-7.81e-02	0.150000	3.26e-01	7.11e-01	1.81e-01	7.10e-01	5.36e-01	2.35e-01
C-type lectin receptors (CLRs)	116	5.15e-04	1.67e-03	0.277	-1.89e-01	-6.88e-02	6.71e-02	-1.24e-02	-1.70e-02	0.177000	4.43e-04	2.01e-01	2.12e-01	8.17e-01	7.52e-01	1.01e-03
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	8.77e-01	8.99e-01	0.275	-1.43e-01	-2.14e-01	-7.38e-02	1.81e-02	-2.21e-02	0.056500	3.72e-01	1.81e-01	6.45e-01	9.10e-01	8.90e-01	7.24e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	8.87e-01	9.07e-01	0.275	-1.96e-01	9.21e-03	-1.65e-01	2.51e-02	-1.86e-02	0.095400	4.06e-01	9.69e-01	4.85e-01	9.15e-01	9.37e-01	6.86e-01
TGFBR1 KD Mutants in Cancer	6	8.87e-01	9.07e-01	0.275	-1.96e-01	9.21e-03	-1.65e-01	2.51e-02	-1.86e-02	0.095400	4.06e-01	9.69e-01	4.85e-01	9.15e-01	9.37e-01	6.86e-01
O-linked glycosylation	81	7.43e-03	1.74e-02	0.275	3.31e-02	1.73e-01	1.85e-01	9.67e-02	1.96e-03	0.032100	6.06e-01	7.18e-03	4.03e-03	1.32e-01	9.76e-01	6.17e-01
G-protein beta:gamma signalling	29	1.82e-01	2.46e-01	0.274	-2.53e-01	1.88e-02	3.82e-02	1.12e-02	-2.42e-02	0.093700	1.84e-02	8.61e-01	7.22e-01	9.17e-01	8.21e-01	3.82e-01
Mitochondrial biogenesis	91	1.54e-03	4.43e-03	0.274	-1.31e-01	-1.86e-01	-5.88e-02	1.27e-01	-2.69e-02	0.055600	3.02e-02	2.21e-03	3.32e-01	3.65e-02	6.57e-01	3.59e-01
Formation of the Editosome	6	9.64e-01	9.70e-01	0.274	-6.53e-03	8.64e-02	1.57e-01	-4.28e-02	-2.02e-01	-0.000380	9.78e-01	7.14e-01	5.05e-01	8.56e-01	3.91e-01	9.99e-01
mRNA Editing: C to U Conversion	6	9.64e-01	9.70e-01	0.274	-6.53e-03	8.64e-02	1.57e-01	-4.28e-02	-2.02e-01	-0.000380	9.78e-01	7.14e-01	5.05e-01	8.56e-01	3.91e-01	9.99e-01
Ephrin signaling	17	5.88e-01	6.38e-01	0.274	-1.55e-01	7.93e-02	-6.13e-03	5.83e-02	1.20e-01	0.163000	2.67e-01	5.71e-01	9.65e-01	6.77e-01	3.92e-01	2.45e-01
Regulation of MITF-M-dependent genes involved in pigmentation	35	2.58e-02	5.01e-02	0.273	-3.27e-02	1.03e-01	1.01e-01	2.26e-01	-2.53e-02	-0.028500	7.38e-01	2.93e-01	3.00e-01	2.05e-02	7.96e-01	7.70e-01
Signaling by TGF-beta Receptor Complex	90	5.78e-04	1.85e-03	0.273	-1.24e-01	-6.26e-03	1.12e-01	1.06e-01	-9.62e-02	0.161000	4.28e-02	9.18e-01	6.54e-02	8.25e-02	1.15e-01	8.14e-03
Signaling by Hedgehog	119	2.75e-04	9.64e-04	0.272	-1.32e-01	-1.11e-01	8.28e-02	7.20e-02	-5.12e-02	0.173000	1.31e-02	3.61e-02	1.19e-01	1.75e-01	3.35e-01	1.12e-03
Activation of HOX genes during differentiation	68	1.54e-02	3.25e-02	0.272	-9.07e-02	-2.01e-01	-1.74e-02	1.19e-01	-8.53e-02	0.060700	1.96e-01	4.10e-03	8.04e-01	9.03e-02	2.24e-01	3.87e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	68	1.54e-02	3.25e-02	0.272	-9.07e-02	-2.01e-01	-1.74e-02	1.19e-01	-8.53e-02	0.060700	1.96e-01	4.10e-03	8.04e-01	9.03e-02	2.24e-01	3.87e-01
Regulation of NF-kappa B signaling	18	6.83e-01	7.23e-01	0.272	-1.51e-01	-1.18e-01	-1.84e-01	5.35e-02	-2.39e-02	0.011400	2.67e-01	3.85e-01	1.78e-01	6.94e-01	8.61e-01	9.33e-01
Axon guidance	453	3.73e-15	5.38e-14	0.272	-1.13e-01	-2.05e-01	2.35e-02	1.30e-02	-1.21e-01	0.062800	3.78e-05	8.54e-14	3.91e-01	6.37e-01	1.08e-05	2.20e-02
Transcriptional activation of mitochondrial biogenesis	52	6.04e-03	1.47e-02	0.272	-9.70e-02	9.30e-02	4.02e-02	2.17e-01	5.48e-02	0.061700	2.26e-01	2.46e-01	6.16e-01	6.70e-03	4.94e-01	4.41e-01
Costimulation by the CD28 family	74	1.93e-02	3.89e-02	0.271	-3.89e-02	7.43e-02	-7.80e-02	1.82e-01	1.64e-01	0.021600	5.63e-01	2.69e-01	2.46e-01	6.68e-03	1.48e-02	7.48e-01
Transcriptional regulation by RUNX3	80	7.80e-03	1.81e-02	0.271	-8.98e-02	-1.93e-01	9.68e-02	1.72e-02	-1.05e-01	0.086100	1.65e-01	2.86e-03	1.34e-01	7.90e-01	1.03e-01	1.83e-01
Metabolism	1801	1.07e-68	2.57e-66	0.271	-1.35e-01	-2.20e-01	-6.31e-02	3.71e-02	-6.02e-03	0.031500	1.63e-21	1.83e-54	9.22e-06	9.17e-03	6.72e-01	2.68e-02
Deubiquitination	225	2.32e-09	1.94e-08	0.270	-1.42e-01	-6.97e-02	9.62e-02	8.58e-02	-7.39e-02	0.161000	2.51e-04	7.16e-02	1.30e-02	2.67e-02	5.63e-02	3.05e-05
Post-translational modification: synthesis of GPI-anchored proteins	57	1.07e-01	1.62e-01	0.270	-1.65e-01	-1.22e-01	-1.21e-01	-5.95e-02	8.33e-02	-0.075100	3.10e-02	1.10e-01	1.15e-01	4.37e-01	2.76e-01	3.27e-01
Miscellaneous transport and binding events	20	7.10e-01	7.46e-01	0.270	1.09e-02	-9.72e-02	1.09e-01	1.73e-02	-2.11e-01	0.081500	9.33e-01	4.52e-01	4.00e-01	8.93e-01	1.02e-01	5.28e-01
SHC-mediated cascade:FGFR1	13	8.78e-01	9.00e-01	0.269	-1.24e-01	2.63e-02	2.61e-02	-1.50e-01	-1.82e-01	0.015200	4.39e-01	8.70e-01	8.70e-01	3.49e-01	2.56e-01	9.24e-01
Regulation of TP53 Degradation	35	2.19e-01	2.85e-01	0.269	-1.52e-01	-1.48e-01	-6.93e-02	9.33e-02	-9.36e-02	0.071500	1.19e-01	1.29e-01	4.78e-01	3.40e-01	3.38e-01	4.64e-01
Diseases associated with glycosaminoglycan metabolism	24	3.32e-01	3.99e-01	0.269	-1.68e-01	-1.57e-01	4.62e-02	6.81e-02	-1.13e-01	-0.008620	1.55e-01	1.82e-01	6.95e-01	5.64e-01	3.37e-01	9.42e-01
Insulin receptor signalling cascade	40	8.54e-02	1.34e-01	0.269	-1.38e-01	9.44e-02	1.42e-01	-3.72e-02	-1.47e-01	0.034600	1.30e-01	3.02e-01	1.19e-01	6.84e-01	1.08e-01	7.05e-01
MyD88 cascade initiated on plasma membrane	95	1.53e-04	5.78e-04	0.269	-2.40e-01	1.97e-02	9.17e-02	-4.12e-02	-3.17e-02	0.059200	5.36e-05	7.40e-01	1.23e-01	4.88e-01	5.93e-01	3.19e-01
Toll Like Receptor 10 (TLR10) Cascade	95	1.53e-04	5.78e-04	0.269	-2.40e-01	1.97e-02	9.17e-02	-4.12e-02	-3.17e-02	0.059200	5.36e-05	7.40e-01	1.23e-01	4.88e-01	5.93e-01	3.19e-01
Toll Like Receptor 5 (TLR5) Cascade	95	1.53e-04	5.78e-04	0.269	-2.40e-01	1.97e-02	9.17e-02	-4.12e-02	-3.17e-02	0.059200	5.36e-05	7.40e-01	1.23e-01	4.88e-01	5.93e-01	3.19e-01
Interferon gamma signaling	87	7.12e-03	1.69e-02	0.269	-4.60e-02	-5.35e-03	-6.94e-02	1.59e-01	1.83e-01	0.080700	4.59e-01	9.31e-01	2.63e-01	1.03e-02	3.13e-03	1.93e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	2.13e-01	2.81e-01	0.269	-8.36e-02	-1.43e-01	-4.67e-02	1.66e-01	5.03e-03	0.123000	3.99e-01	1.49e-01	6.37e-01	9.47e-02	9.60e-01	2.14e-01
Keratan sulfate/keratin metabolism	27	4.97e-01	5.55e-01	0.269	5.69e-03	-6.05e-03	2.15e-01	7.83e-02	-7.63e-02	0.117000	9.59e-01	9.57e-01	5.26e-02	4.81e-01	4.93e-01	2.91e-01
FGFR3 ligand binding and activation	5	9.88e-01	9.90e-01	0.268	8.12e-02	7.12e-02	1.81e-01	-5.70e-02	3.91e-02	0.151000	7.53e-01	7.83e-01	4.83e-01	8.25e-01	8.80e-01	5.59e-01
FGFR3c ligand binding and activation	5	9.88e-01	9.90e-01	0.268	8.12e-02	7.12e-02	1.81e-01	-5.70e-02	3.91e-02	0.151000	7.53e-01	7.83e-01	4.83e-01	8.25e-01	8.80e-01	5.59e-01
Signaling by Non-Receptor Tyrosine Kinases	47	7.29e-03	1.72e-02	0.268	-1.82e-01	-6.32e-02	1.13e-01	1.19e-01	-7.28e-02	0.050600	3.10e-02	4.54e-01	1.81e-01	1.57e-01	3.88e-01	5.48e-01
Signaling by PTK6	47	7.29e-03	1.72e-02	0.268	-1.82e-01	-6.32e-02	1.13e-01	1.19e-01	-7.28e-02	0.050600	3.10e-02	4.54e-01	1.81e-01	1.57e-01	3.88e-01	5.48e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	7.07e-01	7.44e-01	0.268	-8.14e-02	1.25e-01	-7.73e-02	7.21e-02	1.95e-01	-0.008330	5.50e-01	3.59e-01	5.70e-01	5.96e-01	1.51e-01	9.51e-01
Metabolism of steroids	119	1.12e-04	4.33e-04	0.268	-9.64e-02	-1.41e-02	1.29e-01	1.27e-01	-4.08e-03	0.171000	6.94e-02	7.90e-01	1.47e-02	1.66e-02	9.39e-01	1.28e-03
Glutamate binding, activation of AMPA receptors and synaptic plasticity	19	5.83e-01	6.33e-01	0.268	2.87e-02	-3.27e-03	1.90e-01	1.67e-01	-2.54e-03	0.083800	8.29e-01	9.80e-01	1.52e-01	2.09e-01	9.85e-01	5.27e-01
Trafficking of AMPA receptors	19	5.83e-01	6.33e-01	0.268	2.87e-02	-3.27e-03	1.90e-01	1.67e-01	-2.54e-03	0.083800	8.29e-01	9.80e-01	1.52e-01	2.09e-01	9.85e-01	5.27e-01
CDC42 GTPase cycle	139	2.75e-09	2.29e-08	0.268	-4.26e-02	9.48e-02	1.81e-01	1.56e-01	-6.12e-02	0.006680	3.86e-01	5.36e-02	2.33e-04	1.51e-03	2.13e-01	8.92e-01
FGFRL1 modulation of FGFR1 signaling	7	9.35e-01	9.44e-01	0.267	4.00e-02	2.17e-01	5.16e-02	-1.24e-01	-1.55e-02	0.067300	8.54e-01	3.21e-01	8.13e-01	5.68e-01	9.43e-01	7.58e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	6.72e-01	7.13e-01	0.267	1.00e-01	-7.45e-02	9.61e-02	2.03e-01	-1.37e-03	-0.072300	5.31e-01	6.42e-01	5.49e-01	2.06e-01	9.93e-01	6.52e-01
TNFs bind their physiological receptors	24	4.23e-01	4.88e-01	0.266	1.68e-01	8.73e-02	3.78e-02	-1.80e-02	1.75e-01	0.053400	1.54e-01	4.59e-01	7.49e-01	8.79e-01	1.39e-01	6.50e-01
FasL/ CD95L signaling	5	8.91e-01	9.09e-01	0.266	-2.13e-01	6.88e-02	-9.31e-02	6.73e-02	-7.37e-02	0.048000	4.10e-01	7.90e-01	7.19e-01	7.94e-01	7.75e-01	8.52e-01
Downregulation of ERBB2 signaling	24	5.76e-01	6.28e-01	0.266	-1.37e-01	-1.15e-01	-1.11e-01	2.08e-02	4.11e-02	-0.156000	2.45e-01	3.31e-01	3.45e-01	8.60e-01	7.27e-01	1.86e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	1.14e-05	5.42e-05	0.265	-2.46e-01	4.78e-02	7.01e-02	-1.67e-02	1.24e-03	0.049900	1.36e-05	3.98e-01	2.15e-01	7.67e-01	9.82e-01	3.77e-01
Effects of PIP2 hydrolysis	24	3.11e-01	3.80e-01	0.265	9.01e-02	1.14e-01	-2.34e-02	2.16e-01	-2.94e-02	-0.030700	4.45e-01	3.34e-01	8.43e-01	6.68e-02	8.03e-01	7.95e-01
FLT3 signaling through SRC family kinases	6	9.11e-01	9.28e-01	0.265	-3.76e-03	2.17e-01	7.02e-03	1.47e-01	6.10e-03	0.039200	9.87e-01	3.58e-01	9.76e-01	5.33e-01	9.79e-01	8.68e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	4.28e-01	4.92e-01	0.264	-2.16e-01	9.51e-02	7.26e-03	-5.05e-02	1.03e-01	0.027700	8.65e-02	4.51e-01	9.54e-01	6.89e-01	4.14e-01	8.26e-01
Signaling by NTRKs	116	9.01e-06	4.35e-05	0.264	-1.92e-01	5.29e-02	1.48e-01	-2.73e-03	-4.16e-02	0.079500	3.49e-04	3.25e-01	5.99e-03	9.60e-01	4.40e-01	1.39e-01
Disease	1601	1.16e-71	5.03e-69	0.264	-1.29e-01	-1.59e-01	1.22e-02	1.19e-01	-4.28e-02	0.106000	6.95e-18	2.03e-26	4.17e-01	2.09e-15	4.37e-03	1.33e-12
Drug ADME	55	2.72e-03	7.27e-03	0.264	-4.76e-03	-1.89e-01	8.81e-02	1.26e-01	7.21e-02	0.071100	9.51e-01	1.56e-02	2.58e-01	1.05e-01	3.55e-01	3.61e-01
ECM proteoglycans	45	2.86e-01	3.55e-01	0.263	-6.30e-02	3.57e-04	1.23e-01	-1.59e-01	-1.56e-01	-0.022500	4.64e-01	9.97e-01	1.54e-01	6.44e-02	7.03e-02	7.94e-01
Regulation of TP53 Expression and Degradation	36	2.58e-01	3.28e-01	0.263	-1.64e-01	-1.40e-01	-4.25e-02	6.57e-02	-1.18e-01	0.050700	8.85e-02	1.46e-01	6.59e-01	4.95e-01	2.19e-01	5.98e-01
CD28 co-stimulation	33	3.40e-02	6.33e-02	0.262	-1.92e-01	9.19e-02	-1.39e-02	1.47e-01	2.76e-02	0.027400	5.61e-02	3.61e-01	8.90e-01	1.43e-01	7.84e-01	7.86e-01
Transcriptional Regulation by VENTX	38	4.62e-01	5.23e-01	0.262	1.41e-02	5.31e-02	-7.61e-02	1.25e-01	2.11e-01	-0.000010	8.80e-01	5.71e-01	4.17e-01	1.84e-01	2.45e-02	1.00e+00
Adaptive Immune System	763	3.48e-31	1.03e-29	0.262	-9.28e-02	-9.06e-02	5.96e-02	1.06e-01	-7.61e-02	0.177000	1.31e-05	2.09e-05	5.12e-03	5.75e-07	3.52e-04	9.50e-17
Metabolism of fat-soluble vitamins	26	9.64e-02	1.48e-01	0.262	2.00e-02	-2.94e-02	2.35e-01	1.11e-01	4.78e-03	-0.004250	8.60e-01	7.95e-01	3.84e-02	3.26e-01	9.66e-01	9.70e-01
IGF1R signaling cascade	37	6.66e-02	1.10e-01	0.262	-6.29e-02	2.05e-01	1.23e-01	4.33e-02	-7.10e-02	0.024800	5.08e-01	3.06e-02	1.97e-01	6.49e-01	4.55e-01	7.94e-01
Signaling by NOTCH3	42	7.77e-02	1.24e-01	0.262	-8.06e-02	-4.58e-02	1.77e-01	8.17e-02	-1.35e-01	0.062700	3.66e-01	6.07e-01	4.77e-02	3.60e-01	1.30e-01	4.82e-01
IRS-related events triggered by IGF1R	36	9.84e-02	1.51e-01	0.262	-6.06e-02	2.05e-01	1.30e-01	2.29e-02	-7.01e-02	0.023400	5.29e-01	3.36e-02	1.78e-01	8.12e-01	4.66e-01	8.08e-01
Regulation of PTEN gene transcription	59	1.37e-02	2.94e-02	0.261	-3.29e-02	-5.86e-02	-1.86e-02	1.87e-01	1.56e-01	-0.066100	6.62e-01	4.36e-01	8.05e-01	1.31e-02	3.86e-02	3.80e-01
Cell junction organization	76	7.05e-02	1.15e-01	0.261	3.05e-02	1.62e-01	1.11e-01	1.22e-01	1.01e-01	0.057400	6.46e-01	1.47e-02	9.37e-02	6.55e-02	1.27e-01	3.87e-01
Diseases of signal transduction by growth factor receptors and second messengers	399	6.07e-19	1.07e-17	0.261	-1.36e-01	1.17e-03	1.28e-01	1.04e-01	-2.26e-02	0.147000	3.25e-06	9.68e-01	1.09e-05	3.77e-04	4.39e-01	4.47e-07
Toll Like Receptor 9 (TLR9) Cascade	108	6.99e-06	3.45e-05	0.261	-2.43e-01	4.63e-02	5.98e-02	5.51e-03	1.33e-02	0.053500	1.27e-05	4.06e-01	2.83e-01	9.21e-01	8.11e-01	3.37e-01
PTEN Regulation	126	2.67e-05	1.19e-04	0.260	-1.19e-01	-1.59e-01	4.49e-02	1.06e-01	1.60e-02	0.122000	2.15e-02	2.05e-03	3.84e-01	4.03e-02	7.56e-01	1.77e-02
MAPK family signaling cascades	259	8.57e-07	4.93e-06	0.260	-6.31e-02	-1.01e-02	1.66e-01	1.96e-02	-5.62e-02	0.180000	8.04e-02	7.79e-01	4.15e-06	5.88e-01	1.20e-01	5.98e-07
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	3.30e-02	6.18e-02	0.260	-1.20e-01	-1.95e-01	-8.19e-02	8.47e-02	-1.83e-02	-0.022800	7.59e-02	3.88e-03	2.26e-01	2.11e-01	7.87e-01	7.36e-01
MTOR signalling	39	1.35e-01	1.93e-01	0.259	-1.63e-01	-1.31e-01	-6.21e-02	1.25e-01	-5.98e-02	0.018500	7.79e-02	1.58e-01	5.02e-01	1.76e-01	5.18e-01	8.42e-01
RAF-independent MAPK1/3 activation	21	1.05e-01	1.59e-01	0.259	-2.03e-01	3.63e-02	1.06e-01	6.02e-02	-4.01e-02	-0.089500	1.06e-01	7.73e-01	4.02e-01	6.33e-01	7.50e-01	4.78e-01
Nervous system development	471	3.37e-14	4.49e-13	0.259	-1.18e-01	-1.93e-01	1.91e-02	1.21e-02	-1.06e-01	0.063600	1.11e-05	7.86e-13	4.77e-01	6.52e-01	7.65e-05	1.82e-02
Activation of kainate receptors upon glutamate binding	25	5.18e-01	5.73e-01	0.259	-1.04e-01	2.70e-02	1.28e-01	6.95e-02	-8.54e-02	0.164000	3.69e-01	8.16e-01	2.68e-01	5.48e-01	4.60e-01	1.56e-01
LDL clearance	17	2.98e-01	3.67e-01	0.258	-1.57e-01	-5.04e-02	4.84e-02	1.89e-01	-2.03e-02	-0.029100	2.61e-01	7.19e-01	7.30e-01	1.77e-01	8.85e-01	8.36e-01
Signaling by Nuclear Receptors	210	7.37e-11	7.07e-10	0.258	-1.18e-01	-1.93e-02	1.36e-01	1.38e-01	1.72e-02	0.119000	3.28e-03	6.30e-01	6.63e-04	5.62e-04	6.67e-01	2.86e-03
Molecules associated with elastic fibres	26	2.60e-01	3.30e-01	0.258	2.81e-02	-2.30e-02	2.22e-01	-4.63e-02	4.16e-02	0.109000	8.04e-01	8.39e-01	4.99e-02	6.83e-01	7.13e-01	3.38e-01
ERK/MAPK targets	22	3.65e-01	4.31e-01	0.257	-2.50e-01	-5.88e-04	2.74e-03	1.17e-02	-5.65e-02	0.009670	4.20e-02	9.96e-01	9.82e-01	9.24e-01	6.46e-01	9.37e-01
Centrosome maturation	81	7.71e-03	1.79e-02	0.257	-1.27e-02	-1.15e-01	-1.23e-02	2.01e-01	5.68e-02	0.093700	8.44e-01	7.24e-02	8.49e-01	1.76e-03	3.77e-01	1.45e-01
Recruitment of mitotic centrosome proteins and complexes	81	7.71e-03	1.79e-02	0.257	-1.27e-02	-1.15e-01	-1.23e-02	2.01e-01	5.68e-02	0.093700	8.44e-01	7.24e-02	8.49e-01	1.76e-03	3.77e-01	1.45e-01
Resolution of D-Loop Structures	35	2.46e-01	3.16e-01	0.257	-6.24e-02	-1.41e-01	-2.19e-02	1.72e-01	-3.40e-05	0.110000	5.23e-01	1.49e-01	8.23e-01	7.83e-02	1.00e+00	2.59e-01
Signaling by FGFR2	61	8.40e-02	1.33e-01	0.257	-1.12e-01	-1.61e-01	-4.46e-02	4.88e-02	-1.46e-01	0.044300	1.32e-01	2.95e-02	5.47e-01	5.10e-01	4.93e-02	5.50e-01
A tetrasaccharide linker sequence is required for GAG synthesis	16	3.10e-01	3.79e-01	0.257	-3.49e-02	-4.29e-02	6.18e-02	6.42e-02	-1.36e-02	-0.234000	8.09e-01	7.66e-01	6.69e-01	6.57e-01	9.25e-01	1.05e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	4.95e-05	2.10e-04	0.256	-2.38e-01	5.21e-02	6.62e-02	-2.81e-02	3.10e-03	0.032900	3.97e-05	3.68e-01	2.52e-01	6.28e-01	9.57e-01	5.70e-01
Plasma lipoprotein assembly, remodeling, and clearance	55	7.51e-04	2.32e-03	0.256	-6.97e-02	-8.93e-02	1.20e-01	1.88e-01	-3.77e-02	-0.036900	3.71e-01	2.52e-01	1.25e-01	1.57e-02	6.29e-01	6.36e-01
Immune System	1823	1.41e-69	4.52e-67	0.255	-1.20e-01	-4.40e-02	1.04e-01	8.40e-02	-5.46e-02	0.167000	1.82e-17	1.86e-03	1.70e-13	2.87e-09	1.13e-04	4.54e-32
TRAF6 mediated NF-kB activation	23	3.78e-01	4.42e-01	0.254	-8.77e-02	1.32e-01	-3.04e-02	1.37e-01	1.12e-01	-0.086800	4.66e-01	2.72e-01	8.01e-01	2.57e-01	3.54e-01	4.71e-01
Chondroitin sulfate/dermatan sulfate metabolism	37	1.92e-02	3.88e-02	0.254	-8.64e-02	-2.60e-02	5.18e-02	6.75e-02	-9.99e-02	-0.198000	3.63e-01	7.85e-01	5.86e-01	4.77e-01	2.93e-01	3.69e-02
Class A/1 (Rhodopsin-like receptors)	170	6.16e-05	2.53e-04	0.253	4.32e-02	8.64e-02	2.21e-01	-4.63e-02	-3.72e-02	0.050900	3.31e-01	5.20e-02	6.98e-07	2.98e-01	4.03e-01	2.52e-01
Glycolysis	68	1.05e-03	3.10e-03	0.253	-1.66e-01	-6.40e-02	2.56e-02	1.72e-01	1.48e-02	0.038600	1.76e-02	3.61e-01	7.16e-01	1.41e-02	8.33e-01	5.82e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	8.89e-01	9.08e-01	0.252	5.12e-02	-1.58e-01	-1.78e-02	9.02e-02	-3.57e-02	-0.163000	7.90e-01	4.13e-01	9.27e-01	6.39e-01	8.53e-01	3.98e-01
Neurotransmitter release cycle	35	6.41e-01	6.87e-01	0.252	7.53e-02	1.64e-01	1.31e-01	5.85e-02	9.30e-02	0.043000	4.41e-01	9.38e-02	1.80e-01	5.50e-01	3.41e-01	6.60e-01
MyD88 dependent cascade initiated on endosome	101	6.43e-05	2.64e-04	0.251	-2.31e-01	5.04e-02	7.23e-02	-1.97e-02	7.31e-03	0.042300	6.14e-05	3.82e-01	2.09e-01	7.32e-01	8.99e-01	4.63e-01
RHO GTPase cycle	408	5.27e-17	8.29e-16	0.251	-8.07e-02	5.90e-02	1.57e-01	1.12e-01	-1.02e-02	0.125000	5.16e-03	4.11e-02	5.09e-08	1.04e-04	7.25e-01	1.51e-05
Post-translational protein modification	1230	1.10e-51	9.61e-50	0.250	-1.59e-01	-1.17e-01	2.07e-02	9.80e-02	-4.00e-02	0.110000	6.14e-21	6.23e-12	2.22e-01	7.49e-09	1.83e-02	8.43e-11
SLC transporter disorders	75	3.40e-03	8.92e-03	0.250	-8.60e-02	-6.29e-03	-6.85e-02	1.95e-01	7.20e-02	-0.084400	1.98e-01	9.25e-01	3.05e-01	3.49e-03	2.81e-01	2.07e-01
MITF-M-dependent gene expression	81	1.81e-02	3.69e-02	0.250	-5.29e-02	3.90e-02	1.60e-01	1.14e-01	-9.71e-03	0.140000	4.10e-01	5.44e-01	1.30e-02	7.67e-02	8.80e-01	2.92e-02
Glucose metabolism	76	5.11e-04	1.66e-03	0.249	-1.35e-01	-6.77e-02	3.71e-02	1.83e-01	5.69e-02	0.032600	4.24e-02	3.07e-01	5.76e-01	5.76e-03	3.91e-01	6.24e-01
Integrin cell surface interactions	64	9.90e-02	1.52e-01	0.249	-5.00e-02	3.78e-02	2.02e-01	-5.28e-02	-1.93e-02	0.119000	4.89e-01	6.01e-01	5.24e-03	4.65e-01	7.90e-01	1.00e-01
MAPK1/MAPK3 signaling	227	1.96e-05	8.88e-05	0.249	-3.88e-02	-4.02e-02	1.61e-01	3.02e-02	-6.86e-02	0.165000	3.13e-01	2.97e-01	2.82e-05	4.33e-01	7.51e-02	1.92e-05
Lysine catabolism	10	9.29e-01	9.39e-01	0.248	-1.03e-01	1.72e-02	1.36e-01	-1.15e-01	3.08e-02	0.135000	5.73e-01	9.25e-01	4.58e-01	5.29e-01	8.66e-01	4.59e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	5.61e-09	4.44e-08	0.248	-1.29e-01	-1.37e-01	-2.78e-02	6.48e-02	-6.17e-02	0.132000	2.31e-04	9.56e-05	4.27e-01	6.46e-02	7.81e-02	1.66e-04
Amino acid transport across the plasma membrane	24	3.79e-01	4.43e-01	0.247	-6.00e-02	-9.90e-02	-3.50e-02	9.03e-02	-1.83e-01	0.070500	6.11e-01	4.01e-01	7.67e-01	4.44e-01	1.21e-01	5.50e-01
PI3K Cascade	31	1.21e-01	1.78e-01	0.247	-9.19e-02	1.89e-01	9.53e-02	1.01e-02	-8.64e-02	-0.017300	3.76e-01	6.88e-02	3.59e-01	9.23e-01	4.05e-01	8.68e-01
Listeria monocytogenes entry into host cells	17	7.91e-01	8.25e-01	0.247	-2.15e-01	-8.52e-02	-7.87e-04	7.54e-03	-4.07e-02	0.075800	1.25e-01	5.43e-01	9.96e-01	9.57e-01	7.71e-01	5.88e-01
IRS-mediated signalling	35	1.46e-01	2.06e-01	0.246	-8.97e-02	1.82e-01	1.14e-01	-3.71e-03	-7.49e-02	0.024800	3.59e-01	6.21e-02	2.42e-01	9.70e-01	4.43e-01	8.00e-01
SUMOylation of intracellular receptors	26	7.01e-02	1.14e-01	0.246	-1.66e-01	8.72e-02	1.16e-01	7.10e-02	4.31e-02	-0.070800	1.42e-01	4.42e-01	3.08e-01	5.31e-01	7.04e-01	5.32e-01
Intraflagellar transport	47	8.50e-02	1.34e-01	0.246	-8.23e-02	-5.37e-02	-1.05e-01	-2.23e-02	1.73e-01	0.096100	3.29e-01	5.24e-01	2.14e-01	7.91e-01	4.01e-02	2.55e-01
SHC-mediated cascade:FGFR2	13	9.10e-01	9.28e-01	0.244	9.10e-02	7.80e-02	1.12e-01	-3.38e-02	3.25e-02	0.174000	5.70e-01	6.26e-01	4.83e-01	8.33e-01	8.39e-01	2.77e-01
RA biosynthesis pathway	13	8.18e-01	8.46e-01	0.243	2.58e-02	-2.90e-02	-2.21e-01	6.58e-02	6.57e-02	-0.019200	8.72e-01	8.56e-01	1.68e-01	6.81e-01	6.82e-01	9.05e-01
Defective B4GALT7 causes EDS, progeroid type	10	5.17e-01	5.73e-01	0.243	-3.47e-02	-4.70e-02	1.38e-01	1.24e-01	7.70e-02	-0.125000	8.49e-01	7.97e-01	4.51e-01	4.98e-01	6.73e-01	4.94e-01
Striated Muscle Contraction	25	8.02e-01	8.34e-01	0.243	1.03e-01	1.39e-01	1.38e-01	-2.44e-02	-3.94e-02	0.087900	3.75e-01	2.29e-01	2.31e-01	8.33e-01	7.33e-01	4.47e-01
Cellular Senescence	142	5.81e-05	2.43e-04	0.242	-1.27e-01	-1.10e-01	9.88e-02	7.46e-02	-4.95e-02	0.112000	8.75e-03	2.40e-02	4.22e-02	1.25e-01	3.09e-01	2.10e-02
Adrenaline,noradrenaline inhibits insulin secretion	24	5.85e-01	6.35e-01	0.241	-1.04e-01	5.96e-02	1.31e-01	-7.18e-03	-1.43e-01	0.076000	3.77e-01	6.13e-01	2.65e-01	9.51e-01	2.24e-01	5.20e-01
Signaling by ERBB4	45	1.66e-01	2.29e-01	0.241	-1.61e-01	-3.74e-03	1.45e-01	-5.81e-02	-2.30e-02	0.084100	6.14e-02	9.65e-01	9.23e-02	5.00e-01	7.90e-01	3.29e-01
Recruitment of NuMA to mitotic centrosomes	88	8.01e-03	1.86e-02	0.240	-2.38e-02	-1.46e-01	2.63e-02	1.55e-01	2.86e-04	0.106000	6.99e-01	1.83e-02	6.69e-01	1.19e-02	9.96e-01	8.68e-02
Cytosolic sensors of pathogen-associated DNA	63	5.19e-02	8.93e-02	0.240	-7.38e-02	-1.33e-01	-8.56e-02	1.62e-01	-2.12e-02	-0.023000	3.11e-01	6.74e-02	2.40e-01	2.64e-02	7.71e-01	7.52e-01
G alpha (q) signalling events	136	1.11e-03	3.27e-03	0.240	-1.58e-02	1.12e-01	1.74e-01	6.27e-02	-5.31e-02	0.087100	7.51e-01	2.48e-02	4.45e-04	2.07e-01	2.85e-01	7.96e-02
Reproduction	84	2.50e-02	4.88e-02	0.239	-8.33e-02	-1.56e-01	3.24e-02	8.26e-02	-4.48e-02	0.128000	1.87e-01	1.36e-02	6.08e-01	1.91e-01	4.78e-01	4.31e-02
Oncogene Induced Senescence	33	4.08e-01	4.73e-01	0.239	-1.66e-01	3.11e-02	9.32e-02	6.28e-03	-3.40e-02	0.137000	9.83e-02	7.57e-01	3.54e-01	9.50e-01	7.35e-01	1.73e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	9.65e-01	9.71e-01	0.239	-1.34e-01	8.16e-03	-1.95e-02	-6.91e-03	1.20e-01	0.156000	5.38e-01	9.70e-01	9.29e-01	9.75e-01	5.84e-01	4.75e-01
Regulation of TP53 Activity	151	2.92e-06	1.55e-05	0.239	-1.26e-01	-9.53e-02	-5.58e-02	1.69e-01	-9.13e-03	0.020700	7.50e-03	4.33e-02	2.37e-01	3.40e-04	8.46e-01	6.61e-01
RNA polymerase II transcribes snRNA genes	71	4.82e-02	8.39e-02	0.239	-1.45e-01	-1.40e-01	-6.43e-02	9.60e-02	1.79e-02	0.052700	3.51e-02	4.07e-02	3.49e-01	1.62e-01	7.94e-01	4.43e-01
Sensory Perception	185	3.49e-04	1.19e-03	0.239	6.42e-02	9.73e-02	1.80e-01	-5.97e-02	-8.35e-02	0.022900	1.32e-01	2.25e-02	2.48e-05	1.61e-01	5.01e-02	5.91e-01
Extracellular matrix organization	213	1.44e-07	9.22e-07	0.239	-3.76e-02	3.06e-02	2.18e-01	-1.25e-03	-6.38e-02	0.055400	3.44e-01	4.41e-01	4.26e-08	9.75e-01	1.09e-01	1.64e-01
RAF/MAP kinase cascade	222	9.94e-05	3.89e-04	0.239	-2.96e-02	-4.54e-02	1.54e-01	2.04e-02	-6.99e-02	0.158000	4.47e-01	2.44e-01	7.33e-05	6.01e-01	7.29e-02	5.23e-05
Regulated Necrosis	55	1.15e-01	1.71e-01	0.238	-1.10e-01	-5.01e-02	7.05e-03	6.89e-02	2.32e-02	0.192000	1.60e-01	5.21e-01	9.28e-01	3.77e-01	7.66e-01	1.37e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	9.20e-01	9.32e-01	0.238	-7.83e-02	2.07e-01	5.59e-02	6.55e-02	1.09e-02	0.003460	7.20e-01	3.42e-01	7.98e-01	7.64e-01	9.60e-01	9.87e-01
RAC3 GTPase cycle	86	2.23e-02	4.39e-02	0.238	-1.31e-01	4.79e-02	1.54e-01	-3.30e-02	-3.86e-02	0.103000	3.52e-02	4.43e-01	1.38e-02	5.97e-01	5.36e-01	9.76e-02
Defective B3GAT3 causes JDSSDHD	10	5.74e-01	6.26e-01	0.237	2.39e-02	-3.02e-02	1.73e-01	8.79e-02	8.24e-02	-0.102000	8.96e-01	8.69e-01	3.43e-01	6.30e-01	6.52e-01	5.78e-01
MyD88-independent TLR4 cascade	108	3.22e-04	1.10e-03	0.237	-1.92e-01	6.39e-02	9.07e-02	6.79e-04	-1.81e-04	0.085100	5.82e-04	2.51e-01	1.03e-01	9.90e-01	9.97e-01	1.27e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	3.22e-04	1.10e-03	0.237	-1.92e-01	6.39e-02	9.07e-02	6.79e-04	-1.81e-04	0.085100	5.82e-04	2.51e-01	1.03e-01	9.90e-01	9.97e-01	1.27e-01
GPCR ligand binding	232	2.55e-05	1.14e-04	0.235	4.52e-02	1.16e-01	1.93e-01	-1.60e-02	-1.69e-02	0.045100	2.36e-01	2.36e-03	3.86e-07	6.75e-01	6.57e-01	2.37e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	2.23e-02	4.39e-02	0.235	-7.44e-02	1.13e-01	7.09e-02	1.28e-01	-7.92e-02	0.097500	3.68e-01	1.71e-01	3.91e-01	1.22e-01	3.38e-01	2.38e-01
Diseases of mitotic cell cycle	38	3.08e-01	3.78e-01	0.235	-7.71e-02	-1.49e-01	-1.52e-02	7.19e-02	4.94e-02	0.139000	4.11e-01	1.12e-01	8.72e-01	4.43e-01	5.98e-01	1.37e-01
Sensory processing of sound by inner hair cells of the cochlea	54	2.15e-01	2.82e-01	0.234	4.64e-02	1.10e-01	9.88e-02	1.66e-01	5.93e-02	0.006990	5.55e-01	1.63e-01	2.09e-01	3.53e-02	4.51e-01	9.29e-01
Synthesis of substrates in N-glycan biosythesis	58	6.06e-02	1.02e-01	0.234	-9.85e-02	-1.62e-01	-2.91e-02	1.34e-01	-9.71e-03	-0.009380	1.94e-01	3.29e-02	7.01e-01	7.75e-02	8.98e-01	9.02e-01
Signaling by FGFR1	42	2.67e-01	3.36e-01	0.233	-1.59e-01	5.09e-02	6.88e-02	-5.02e-02	-1.16e-01	0.078100	7.48e-02	5.68e-01	4.40e-01	5.74e-01	1.95e-01	3.81e-01
Sensory processing of sound	57	1.50e-01	2.10e-01	0.233	3.65e-02	9.25e-02	1.03e-01	1.78e-01	4.04e-02	0.023700	6.33e-01	2.27e-01	1.78e-01	2.02e-02	5.98e-01	7.57e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	3.92e-01	4.57e-01	0.231	-1.35e-01	-8.63e-02	-3.26e-02	1.20e-01	-9.31e-02	0.061400	2.23e-01	4.38e-01	7.70e-01	2.82e-01	4.02e-01	5.81e-01
Signaling by Receptor Tyrosine Kinases	440	1.86e-16	2.89e-15	0.231	-1.38e-01	-3.40e-03	1.54e-01	9.73e-03	-6.39e-02	0.081400	6.71e-07	9.03e-01	3.30e-08	7.26e-01	2.16e-02	3.43e-03
Activated NOTCH1 Transmits Signal to the Nucleus	27	1.81e-01	2.45e-01	0.231	-1.44e-01	-1.51e-02	8.46e-02	1.43e-01	-6.67e-02	0.020500	1.94e-01	8.92e-01	4.47e-01	1.99e-01	5.49e-01	8.54e-01
SUMOylation of transcription cofactors	44	3.08e-02	5.83e-02	0.230	-1.19e-01	-3.21e-02	-6.03e-03	1.88e-01	-1.78e-02	-0.046800	1.72e-01	7.12e-01	9.45e-01	3.11e-02	8.39e-01	5.91e-01
Cilium Assembly	186	1.14e-05	5.42e-05	0.230	-1.04e-01	-4.91e-02	-6.75e-02	8.69e-02	1.21e-01	0.114000	1.41e-02	2.49e-01	1.12e-01	4.11e-02	4.53e-03	7.22e-03
NOD1/2 Signaling Pathway	36	3.03e-01	3.72e-01	0.229	-1.98e-01	8.11e-02	1.49e-02	-6.95e-02	-5.68e-03	0.040800	3.97e-02	4.00e-01	8.77e-01	4.70e-01	9.53e-01	6.71e-01
p75 NTR receptor-mediated signalling	89	5.90e-04	1.88e-03	0.229	-6.24e-02	-3.39e-02	9.64e-02	1.91e-01	6.99e-03	0.037400	3.09e-01	5.80e-01	1.16e-01	1.84e-03	9.09e-01	5.42e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.87e-01	4.52e-01	0.228	-8.75e-02	-1.60e-01	-1.42e-02	5.88e-02	4.11e-02	0.116000	3.63e-01	9.77e-02	8.82e-01	5.41e-01	6.70e-01	2.28e-01
Neurotransmitter receptors and postsynaptic signal transmission	132	7.51e-03	1.76e-02	0.228	-5.57e-02	7.16e-02	1.61e-01	4.95e-03	-8.21e-02	0.105000	2.69e-01	1.55e-01	1.44e-03	9.22e-01	1.03e-01	3.77e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	10	5.53e-01	6.05e-01	0.227	-5.27e-02	-5.30e-02	1.74e-01	8.11e-02	4.25e-02	-0.085000	7.73e-01	7.72e-01	3.39e-01	6.57e-01	8.16e-01	6.42e-01
Fatty acid metabolism	152	1.27e-04	4.89e-04	0.227	-1.28e-01	-1.56e-01	-2.94e-02	-4.96e-02	5.79e-02	0.063900	6.35e-03	9.04e-04	5.32e-01	2.91e-01	2.18e-01	1.74e-01
Regulation of endogenous retroelements	92	2.57e-02	4.99e-02	0.227	1.99e-02	-5.71e-02	3.00e-02	1.91e-01	4.43e-02	0.092200	7.42e-01	3.44e-01	6.19e-01	1.54e-03	4.63e-01	1.26e-01
Glycerophospholipid biosynthesis	104	1.40e-02	2.98e-02	0.227	-2.11e-01	-4.36e-02	4.70e-03	-4.37e-02	-5.09e-02	0.024100	2.07e-04	4.42e-01	9.34e-01	4.42e-01	3.69e-01	6.71e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.39e-02	2.97e-02	0.226	-3.27e-02	-1.34e-02	5.56e-02	2.13e-01	-2.84e-03	0.036200	6.39e-01	8.48e-01	4.24e-01	2.17e-03	9.68e-01	6.03e-01
SHC-mediated cascade:FGFR4	11	9.72e-01	9.77e-01	0.225	-7.16e-02	5.43e-02	1.41e-01	-2.10e-02	-8.15e-03	0.149000	6.81e-01	7.55e-01	4.19e-01	9.04e-01	9.63e-01	3.91e-01
Organelle biogenesis and maintenance	277	3.77e-08	2.66e-07	0.225	-1.14e-01	-9.46e-02	-6.50e-02	1.01e-01	7.25e-02	0.095500	1.10e-03	6.74e-03	6.25e-02	3.96e-03	3.80e-02	6.26e-03
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	9.02e-01	9.20e-01	0.225	-8.92e-02	1.02e-01	-9.66e-02	-5.28e-02	1.32e-01	-0.050800	5.63e-01	5.08e-01	5.31e-01	7.33e-01	3.91e-01	7.42e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	8.06e-01	8.37e-01	0.224	1.39e-02	1.83e-01	7.03e-02	-6.31e-03	5.54e-02	0.091200	9.08e-01	1.28e-01	5.60e-01	9.58e-01	6.46e-01	4.49e-01
Phospholipid metabolism	181	5.64e-08	3.83e-07	0.223	-1.89e-01	8.27e-02	5.16e-02	3.23e-02	1.18e-02	0.058000	1.12e-05	5.49e-02	2.31e-01	4.53e-01	7.85e-01	1.79e-01
Signaling by NOTCH1	66	3.92e-03	1.00e-02	0.223	-6.80e-02	5.04e-02	1.11e-01	1.73e-01	1.24e-02	0.000457	3.40e-01	4.79e-01	1.17e-01	1.48e-02	8.62e-01	9.95e-01
Ovarian tumor domain proteases	37	1.78e-01	2.42e-01	0.223	-8.03e-02	9.93e-02	1.13e-01	1.23e-01	-3.40e-02	0.066000	3.98e-01	2.96e-01	2.35e-01	1.94e-01	7.20e-01	4.87e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	3.86e-02	7.07e-02	0.223	-1.35e-01	-2.57e-02	-7.65e-02	1.28e-01	5.12e-02	0.075500	5.70e-02	7.18e-01	2.83e-01	7.27e-02	4.72e-01	2.89e-01
Transcriptional Regulation by TP53	343	4.02e-11	4.04e-10	0.222	-1.14e-01	-1.28e-01	-2.24e-02	1.25e-01	-2.61e-02	0.058100	2.72e-04	4.72e-05	4.76e-01	7.43e-05	4.07e-01	6.46e-02
WNT ligand biogenesis and trafficking	19	7.08e-01	7.44e-01	0.222	-9.61e-02	1.80e-01	1.47e-02	-1.59e-02	6.38e-02	0.055100	4.68e-01	1.74e-01	9.12e-01	9.05e-01	6.30e-01	6.78e-01
PI3K/AKT Signaling in Cancer	83	1.44e-03	4.15e-03	0.221	-3.82e-02	1.07e-01	1.80e-01	4.22e-02	-1.77e-02	-0.035800	5.48e-01	9.06e-02	4.48e-03	5.06e-01	7.81e-01	5.73e-01
Toll Like Receptor 3 (TLR3) Cascade	104	2.73e-03	7.30e-03	0.221	-1.69e-01	5.48e-02	9.48e-02	5.63e-03	-1.48e-03	0.091000	2.97e-03	3.35e-01	9.48e-02	9.21e-01	9.79e-01	1.09e-01
Signaling by ERBB2	44	1.76e-01	2.40e-01	0.220	-2.08e-01	-2.49e-02	1.30e-02	2.72e-02	-4.68e-02	0.042200	1.72e-02	7.75e-01	8.81e-01	7.55e-01	5.91e-01	6.28e-01
Metal ion SLC transporters	19	5.41e-01	5.95e-01	0.220	-1.55e-01	-3.76e-05	9.53e-02	8.35e-02	-8.46e-02	0.036900	2.44e-01	1.00e+00	4.72e-01	5.28e-01	5.23e-01	7.81e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	3.57e-01	4.23e-01	0.219	-1.21e-01	2.88e-02	4.98e-02	6.40e-02	-1.11e-01	0.117000	2.53e-01	7.85e-01	6.37e-01	5.44e-01	2.94e-01	2.69e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	1.35e-01	1.94e-01	0.218	-9.51e-03	3.19e-02	9.85e-02	1.84e-01	5.34e-02	-0.007850	9.13e-01	7.14e-01	2.58e-01	3.46e-02	5.40e-01	9.28e-01
CaMK IV-mediated phosphorylation of CREB	8	9.73e-01	9.77e-01	0.218	-9.79e-02	-3.08e-02	-1.35e-01	-8.09e-03	1.25e-01	0.056400	6.31e-01	8.80e-01	5.10e-01	9.68e-01	5.41e-01	7.82e-01
G alpha (i) signalling events	192	5.92e-04	1.88e-03	0.217	-5.11e-02	2.27e-02	1.77e-01	-5.12e-02	-5.94e-02	0.079900	2.22e-01	5.87e-01	2.39e-05	2.22e-01	1.56e-01	5.63e-02
RIPK1-mediated regulated necrosis	31	4.28e-01	4.92e-01	0.216	-8.90e-02	7.02e-02	2.73e-02	1.09e-02	-3.92e-02	0.177000	3.91e-01	4.99e-01	7.93e-01	9.16e-01	7.06e-01	8.84e-02
Regulation of necroptotic cell death	31	4.28e-01	4.92e-01	0.216	-8.90e-02	7.02e-02	2.73e-02	1.09e-02	-3.92e-02	0.177000	3.91e-01	4.99e-01	7.93e-01	9.16e-01	7.06e-01	8.84e-02
Signal Transduction	2022	2.21e-61	3.03e-59	0.215	-6.93e-02	2.59e-02	1.47e-01	8.46e-02	-3.42e-02	0.104000	2.91e-07	5.51e-02	9.20e-28	3.64e-10	1.14e-02	1.20e-14
Transport of inorganic cations/anions and amino acids/oligopeptides	78	9.99e-02	1.53e-01	0.215	1.08e-02	1.00e-01	7.34e-02	1.54e-01	3.07e-02	0.077800	8.69e-01	1.27e-01	2.62e-01	1.91e-02	6.39e-01	2.35e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	1.43e-02	3.04e-02	0.214	-4.38e-02	-2.59e-02	1.07e-01	9.95e-02	-6.49e-02	0.133000	4.13e-01	6.28e-01	4.50e-02	6.31e-02	2.25e-01	1.28e-02
Biological oxidations	133	4.65e-03	1.17e-02	0.214	-1.20e-01	-1.59e-01	-3.12e-02	-6.48e-02	6.99e-03	-0.033100	1.73e-02	1.56e-03	5.35e-01	1.97e-01	8.89e-01	5.09e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	1.77e-01	2.41e-01	0.214	-2.04e-02	-7.44e-02	1.61e-03	1.48e-01	8.49e-02	0.104000	7.83e-01	3.15e-01	9.83e-01	4.60e-02	2.51e-01	1.61e-01
Heparan sulfate/heparin (HS-GAG) metabolism	39	3.15e-01	3.84e-01	0.212	-1.20e-01	-5.82e-02	-5.29e-02	4.04e-02	-9.20e-02	-0.120000	1.95e-01	5.29e-01	5.67e-01	6.62e-01	3.20e-01	1.97e-01
Anchoring of the basal body to the plasma membrane	97	2.90e-02	5.54e-02	0.211	-4.37e-02	-4.87e-02	-2.13e-02	1.49e-01	6.99e-02	0.113000	4.57e-01	4.07e-01	7.18e-01	1.14e-02	2.34e-01	5.42e-02
Glycosaminoglycan metabolism	95	6.54e-04	2.06e-03	0.211	-7.15e-02	-1.64e-02	1.47e-01	1.12e-01	-6.76e-02	0.018900	2.29e-01	7.82e-01	1.36e-02	5.92e-02	2.55e-01	7.50e-01
Signaling by GPCR	432	8.07e-10	7.17e-09	0.209	-2.36e-03	1.12e-01	1.61e-01	4.79e-02	7.66e-03	0.051300	9.33e-01	6.30e-05	9.06e-09	8.79e-02	7.85e-01	6.76e-02
Regulation of FZD by ubiquitination	15	8.89e-01	9.08e-01	0.208	-9.44e-02	1.18e-01	7.73e-02	-5.38e-02	-7.81e-02	0.072700	5.27e-01	4.27e-01	6.04e-01	7.18e-01	6.00e-01	6.26e-01
Signaling by FGFR in disease	52	1.99e-01	2.65e-01	0.208	-1.33e-01	-3.79e-02	1.89e-02	9.74e-02	6.42e-05	0.119000	9.75e-02	6.37e-01	8.14e-01	2.25e-01	9.99e-01	1.37e-01
Death Receptor Signaling	145	2.71e-04	9.53e-04	0.207	-5.74e-02	5.84e-02	8.96e-02	1.47e-01	5.17e-02	0.061600	2.33e-01	2.25e-01	6.27e-02	2.21e-03	2.82e-01	2.00e-01
Metabolism of water-soluble vitamins and cofactors	114	9.80e-03	2.19e-02	0.207	-3.94e-02	-1.03e-01	-3.41e-02	1.17e-01	1.08e-01	0.063700	4.67e-01	5.65e-02	5.30e-01	3.09e-02	4.61e-02	2.40e-01
Nuclear signaling by ERBB4	24	1.96e-01	2.62e-01	0.205	-1.42e-01	-6.29e-02	1.07e-01	4.13e-02	5.02e-02	-0.046800	2.27e-01	5.94e-01	3.62e-01	7.26e-01	6.70e-01	6.91e-01
NCAM signaling for neurite out-growth	47	4.80e-01	5.38e-01	0.205	1.68e-02	1.87e-01	5.53e-02	2.80e-02	5.13e-02	0.016800	8.42e-01	2.67e-02	5.12e-01	7.40e-01	5.43e-01	8.42e-01
TP53 Regulates Transcription of Cell Death Genes	42	3.05e-01	3.74e-01	0.204	-6.84e-03	6.28e-02	4.07e-03	1.00e-01	9.80e-02	-0.135000	9.39e-01	4.81e-01	9.64e-01	2.62e-01	2.72e-01	1.31e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	9.22e-01	9.34e-01	0.204	1.54e-03	1.16e-01	-5.86e-02	7.76e-02	1.35e-01	-0.024700	9.90e-01	3.68e-01	6.50e-01	5.48e-01	2.96e-01	8.48e-01
Cytokine Signaling in Immune system	659	3.96e-16	6.08e-15	0.204	-8.61e-02	-8.64e-03	9.40e-02	7.60e-02	1.82e-02	0.139000	1.64e-04	7.05e-01	3.90e-05	8.84e-04	4.25e-01	1.14e-09
MITF-M-regulated melanocyte development	109	1.11e-02	2.45e-02	0.203	-1.17e-01	-1.39e-02	1.05e-01	6.19e-02	-3.82e-02	0.104000	3.41e-02	8.03e-01	5.75e-02	2.64e-01	4.90e-01	6.11e-02
Ion channel transport	136	8.20e-03	1.90e-02	0.203	2.46e-03	6.59e-02	1.62e-01	7.83e-02	1.46e-02	0.063600	9.61e-01	1.85e-01	1.08e-03	1.15e-01	7.68e-01	2.00e-01
PIP3 activates AKT signaling	232	5.04e-07	2.96e-06	0.202	-1.26e-01	-4.04e-02	1.16e-01	4.87e-02	-1.47e-02	0.085500	9.20e-04	2.89e-01	2.42e-03	2.01e-01	7.00e-01	2.49e-02
Inflammasomes	21	4.39e-01	5.02e-01	0.202	-1.53e-01	6.46e-02	9.99e-02	4.20e-03	2.81e-02	-0.048800	2.24e-01	6.08e-01	4.28e-01	9.73e-01	8.24e-01	6.99e-01
GPCR downstream signalling	389	3.51e-08	2.50e-07	0.201	-1.79e-02	9.46e-02	1.57e-01	4.70e-02	1.74e-03	0.065900	5.44e-01	1.36e-03	1.12e-07	1.12e-01	9.53e-01	2.58e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	1.27e-01	1.85e-01	0.198	-1.71e-01	6.48e-02	6.35e-02	-4.32e-02	-1.04e-02	0.006470	2.72e-02	4.02e-01	4.11e-01	5.76e-01	8.93e-01	9.33e-01
Metabolism of vitamins and cofactors	163	2.50e-04	8.85e-04	0.198	-4.82e-02	-1.41e-01	-1.43e-02	9.94e-02	7.31e-02	0.037100	2.88e-01	1.84e-03	7.52e-01	2.86e-02	1.07e-01	4.14e-01
Assembly and cell surface presentation of NMDA receptors	30	6.46e-01	6.91e-01	0.198	5.65e-02	9.94e-02	1.14e-01	-9.27e-02	-6.43e-03	-0.066200	5.92e-01	3.46e-01	2.81e-01	3.79e-01	9.51e-01	5.30e-01
Cytochrome P450 - arranged by substrate type	32	3.87e-01	4.52e-01	0.197	-3.44e-02	6.34e-02	1.32e-01	-9.77e-02	8.03e-02	0.012700	7.36e-01	5.35e-01	1.98e-01	3.39e-01	4.32e-01	9.01e-01
Assembly of collagen fibrils and other multimeric structures	41	4.82e-01	5.39e-01	0.196	1.11e-02	1.20e-01	1.51e-01	-2.09e-02	2.57e-02	-0.007710	9.02e-01	1.82e-01	9.43e-02	8.17e-01	7.76e-01	9.32e-01
Metabolism of carbohydrates	236	1.76e-08	1.32e-07	0.196	-1.32e-01	-8.99e-02	3.79e-02	1.03e-01	-2.97e-02	0.004790	4.83e-04	1.74e-02	3.16e-01	6.30e-03	4.33e-01	8.99e-01
Collagen biosynthesis and modifying enzymes	45	1.33e-01	1.91e-01	0.196	-1.06e-01	1.49e-02	1.18e-01	8.92e-02	5.33e-02	0.046100	2.19e-01	8.63e-01	1.70e-01	3.00e-01	5.36e-01	5.93e-01
Nicotinate metabolism	26	8.27e-01	8.53e-01	0.196	-7.15e-02	3.85e-02	5.54e-02	2.08e-03	3.38e-02	0.166000	5.28e-01	7.34e-01	6.25e-01	9.85e-01	7.65e-01	1.43e-01
Negative regulation of MAPK pathway	42	6.27e-01	6.75e-01	0.194	-1.45e-01	-4.23e-02	6.85e-02	-3.21e-02	-7.64e-02	0.056600	1.03e-01	6.35e-01	4.42e-01	7.19e-01	3.92e-01	5.26e-01
Stimuli-sensing channels	78	1.20e-01	1.77e-01	0.193	1.47e-02	8.71e-02	1.66e-01	1.65e-02	3.34e-02	0.025400	8.22e-01	1.84e-01	1.14e-02	8.01e-01	6.10e-01	6.98e-01
Intracellular signaling by second messengers	264	7.81e-08	5.17e-07	0.193	-1.11e-01	-1.35e-02	1.20e-01	6.28e-02	2.51e-03	0.080200	1.98e-03	7.05e-01	8.10e-04	7.92e-02	9.44e-01	2.49e-02
Elastic fibre formation	33	2.83e-01	3.52e-01	0.192	1.70e-02	2.84e-02	1.84e-01	-1.93e-02	3.42e-02	-0.015100	8.66e-01	7.78e-01	6.74e-02	8.48e-01	7.34e-01	8.80e-01
Gene expression (Transcription)	1390	1.74e-34	5.85e-33	0.191	-7.83e-02	-4.42e-02	-2.17e-02	1.35e-01	5.85e-02	0.078300	1.01e-06	5.80e-03	1.77e-01	3.11e-17	2.60e-04	1.03e-06
Phospholipase C-mediated cascade; FGFR3	5	9.94e-01	9.94e-01	0.191	8.20e-02	3.59e-02	2.99e-02	-1.21e-01	-1.32e-02	-0.113000	7.51e-01	8.89e-01	9.08e-01	6.40e-01	9.59e-01	6.62e-01
Neuronal System	258	3.10e-04	1.07e-03	0.190	1.80e-02	1.14e-01	1.49e-01	4.63e-03	-2.81e-03	0.023300	6.18e-01	1.66e-03	3.88e-05	8.98e-01	9.38e-01	5.19e-01
RNA Polymerase II Transcription	1184	2.83e-28	7.33e-27	0.189	-7.17e-02	-3.68e-02	-8.39e-03	1.32e-01	6.33e-02	0.087700	3.26e-05	3.31e-02	6.27e-01	1.72e-14	2.48e-04	3.76e-07
Nicotinamide salvaging	15	9.71e-01	9.76e-01	0.187	-8.46e-02	-7.21e-02	5.47e-02	3.16e-03	-1.27e-01	0.058200	5.70e-01	6.29e-01	7.14e-01	9.83e-01	3.94e-01	6.96e-01
VEGFR2 mediated vascular permeability	25	3.77e-01	4.42e-01	0.187	-1.33e-01	-9.47e-03	5.53e-02	1.11e-01	7.27e-03	-0.040800	2.50e-01	9.35e-01	6.32e-01	3.35e-01	9.50e-01	7.24e-01
Generic Transcription Pathway	1066	3.28e-24	6.63e-23	0.186	-6.59e-02	-2.11e-02	-2.45e-03	1.33e-01	6.96e-02	0.085000	2.81e-04	2.44e-01	8.92e-01	2.56e-13	1.25e-04	2.83e-06
Metabolism of lipids	629	5.77e-15	7.97e-14	0.185	-1.36e-01	-4.43e-02	5.85e-02	4.41e-02	3.59e-03	0.092800	6.35e-09	5.80e-02	1.23e-02	5.91e-02	8.78e-01	7.17e-05
Transmission across Chemical Synapses	176	1.35e-02	2.91e-02	0.183	-2.72e-02	9.20e-02	1.37e-01	9.88e-03	-3.66e-02	0.064600	5.34e-01	3.54e-02	1.70e-03	8.21e-01	4.02e-01	1.39e-01
Collagen formation	63	9.00e-02	1.40e-01	0.179	-5.23e-02	3.35e-02	1.42e-01	6.30e-02	5.26e-02	0.033500	4.73e-01	6.46e-01	5.07e-02	3.87e-01	4.70e-01	6.46e-01
Sensory processing of sound by outer hair cells of the cochlea	40	6.66e-01	7.08e-01	0.178	8.25e-02	6.15e-02	6.84e-02	1.21e-01	-3.02e-02	-0.032900	3.67e-01	5.01e-01	4.54e-01	1.86e-01	7.41e-01	7.19e-01
RUNX2 regulates osteoblast differentiation	16	8.77e-01	8.99e-01	0.176	-1.41e-01	9.00e-02	4.52e-02	-2.10e-02	-2.26e-02	0.010800	3.30e-01	5.33e-01	7.54e-01	8.84e-01	8.76e-01	9.41e-01
RND1 GTPase cycle	36	6.42e-01	6.87e-01	0.175	-4.94e-02	1.53e-02	5.65e-02	9.51e-02	-5.33e-02	0.113000	6.08e-01	8.74e-01	5.58e-01	3.23e-01	5.80e-01	2.39e-01
Endogenous sterols	16	9.14e-01	9.29e-01	0.175	-9.00e-02	3.65e-02	-3.12e-02	1.79e-02	1.06e-01	-0.092300	5.33e-01	8.00e-01	8.29e-01	9.01e-01	4.61e-01	5.23e-01
Epigenetic regulation of gene expression	263	1.72e-05	7.89e-05	0.174	-4.81e-02	-3.55e-02	1.17e-02	1.52e-01	1.63e-02	0.057400	1.79e-01	3.21e-01	7.43e-01	2.26e-05	6.50e-01	1.09e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	9.82e-01	9.84e-01	0.174	9.69e-02	6.36e-02	-3.98e-02	1.27e-02	1.18e-01	0.031500	5.78e-01	7.15e-01	8.19e-01	9.42e-01	4.98e-01	8.56e-01
The canonical retinoid cycle in rods (twilight vision)	9	9.41e-01	9.50e-01	0.173	-2.04e-02	-1.93e-02	4.92e-02	-3.72e-02	3.32e-03	-0.160000	9.16e-01	9.20e-01	7.98e-01	8.47e-01	9.86e-01	4.07e-01
FOXO-mediated transcription	57	2.32e-01	3.00e-01	0.173	-8.96e-02	5.07e-02	1.19e-01	7.67e-03	-7.21e-02	0.010000	2.42e-01	5.08e-01	1.21e-01	9.20e-01	3.47e-01	8.96e-01
Developmental Biology	902	3.03e-15	4.44e-14	0.171	-7.86e-02	-8.67e-02	6.15e-02	5.00e-02	-6.34e-02	0.071200	6.25e-05	1.02e-05	1.75e-03	1.09e-02	1.24e-03	2.91e-04
Signaling by FGFR2 in disease	33	8.16e-01	8.45e-01	0.170	-5.45e-02	-1.16e-01	-6.09e-02	7.27e-02	-1.47e-02	0.056700	5.88e-01	2.49e-01	5.45e-01	4.70e-01	8.83e-01	5.73e-01
Diseases of metabolism	196	9.50e-03	2.13e-02	0.168	-9.55e-02	-1.26e-01	-3.47e-02	3.94e-02	-8.76e-03	-0.019500	2.11e-02	2.44e-03	4.02e-01	3.41e-01	8.33e-01	6.37e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	35	2.65e-01	3.34e-01	0.165	-2.82e-02	5.71e-02	-3.18e-02	9.59e-02	-1.10e-01	-0.028500	7.73e-01	5.59e-01	7.45e-01	3.26e-01	2.59e-01	7.71e-01
Transport of small molecules	547	3.99e-10	3.66e-09	0.165	-6.17e-02	-5.53e-02	9.86e-02	6.31e-02	-4.06e-02	0.069700	1.36e-02	2.69e-02	8.04e-05	1.16e-02	1.04e-01	5.35e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	9.34e-01	9.44e-01	0.163	-7.72e-02	-9.53e-02	-6.60e-02	5.59e-02	3.98e-02	-0.051200	5.21e-01	4.29e-01	5.84e-01	6.43e-01	7.41e-01	6.71e-01
TNFR1-induced NF-kappa-B signaling pathway	32	9.17e-01	9.30e-01	0.163	1.81e-02	1.11e-01	-1.09e-02	3.63e-02	1.07e-01	0.031600	8.59e-01	2.78e-01	9.15e-01	7.23e-01	2.93e-01	7.57e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	9.11e-01	9.28e-01	0.162	-5.45e-02	9.27e-02	9.25e-02	1.40e-02	5.11e-02	0.058000	6.44e-01	4.32e-01	4.33e-01	9.06e-01	6.65e-01	6.23e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	18	9.76e-01	9.79e-01	0.161	-5.44e-02	3.02e-02	-1.66e-02	-1.19e-01	-6.39e-02	-0.060200	6.90e-01	8.25e-01	9.03e-01	3.83e-01	6.39e-01	6.58e-01
Beta-oxidation of very long chain fatty acids	11	9.89e-01	9.90e-01	0.161	7.39e-02	-5.27e-02	6.34e-02	-3.02e-02	-9.91e-02	0.053900	6.71e-01	7.62e-01	7.16e-01	8.62e-01	5.69e-01	7.57e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	2.16e-01	2.83e-01	0.152	-7.70e-02	-4.23e-02	4.38e-02	1.11e-01	2.51e-03	-0.031700	3.32e-01	5.94e-01	5.81e-01	1.62e-01	9.75e-01	6.90e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	2.16e-01	2.83e-01	0.152	-7.70e-02	-4.23e-02	4.38e-02	1.11e-01	2.51e-03	-0.031700	3.32e-01	5.94e-01	5.81e-01	1.62e-01	9.75e-01	6.90e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	2.16e-01	2.83e-01	0.152	-7.70e-02	-4.23e-02	4.38e-02	1.11e-01	2.51e-03	-0.031700	3.32e-01	5.94e-01	5.81e-01	1.62e-01	9.75e-01	6.90e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	2.16e-01	2.83e-01	0.152	-7.70e-02	-4.23e-02	4.38e-02	1.11e-01	2.51e-03	-0.031700	3.32e-01	5.94e-01	5.81e-01	1.62e-01	9.75e-01	6.90e-01
Signaling by NOTCH1 in Cancer	53	2.16e-01	2.83e-01	0.152	-7.70e-02	-4.23e-02	4.38e-02	1.11e-01	2.51e-03	-0.031700	3.32e-01	5.94e-01	5.81e-01	1.62e-01	9.75e-01	6.90e-01
TNF signaling	56	6.54e-01	6.97e-01	0.149	-6.06e-02	6.46e-02	4.31e-02	5.26e-02	6.25e-02	0.077200	4.33e-01	4.03e-01	5.77e-01	4.96e-01	4.19e-01	3.17e-01
FGFR4 ligand binding and activation	5	9.95e-01	9.95e-01	0.146	9.30e-02	-1.88e-02	6.12e-03	-9.27e-02	4.34e-02	-0.043800	7.19e-01	9.42e-01	9.81e-01	7.20e-01	8.67e-01	8.65e-01
Post NMDA receptor activation events	60	8.21e-01	8.48e-01	0.142	-7.34e-02	-1.16e-02	7.03e-02	-5.76e-03	-4.52e-02	0.087700	3.26e-01	8.77e-01	3.46e-01	9.38e-01	5.45e-01	2.40e-01
Signaling by FGFR	73	5.40e-01	5.95e-01	0.141	-8.30e-02	-6.73e-02	-2.76e-02	3.95e-02	-7.53e-02	0.022000	2.20e-01	3.20e-01	6.83e-01	5.60e-01	2.66e-01	7.45e-01
Diseases of glycosylation	104	6.18e-02	1.03e-01	0.140	-3.02e-02	-3.92e-02	2.44e-02	1.18e-01	-7.94e-03	-0.050500	5.95e-01	4.90e-01	6.67e-01	3.83e-02	8.89e-01	3.74e-01
Lewis blood group biosynthesis	13	9.57e-01	9.65e-01	0.138	-2.09e-02	5.78e-02	-8.67e-02	-8.52e-03	-6.30e-02	-0.060700	8.96e-01	7.18e-01	5.88e-01	9.58e-01	6.94e-01	7.05e-01
Visual phototransduction	58	7.26e-01	7.61e-01	0.137	5.21e-02	-3.62e-02	8.83e-02	-1.09e-02	-8.24e-02	-0.007910	4.92e-01	6.34e-01	2.45e-01	8.86e-01	2.78e-01	9.17e-01
Activation of NMDA receptors and postsynaptic events	70	6.90e-01	7.29e-01	0.137	-9.36e-02	9.79e-03	6.94e-02	-2.56e-02	-4.22e-02	0.050600	1.76e-01	8.87e-01	3.15e-01	7.11e-01	5.41e-01	4.64e-01
Regulation of TNFR1 signaling	47	8.84e-01	9.04e-01	0.133	-1.13e-02	8.26e-02	5.38e-02	6.42e-02	4.00e-02	0.046100	8.94e-01	3.27e-01	5.23e-01	4.46e-01	6.36e-01	5.84e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	9.15e-01	9.29e-01	0.130	-2.12e-02	-6.37e-02	8.73e-02	5.90e-02	2.71e-02	-0.025300	8.91e-01	6.80e-01	5.72e-01	7.02e-01	8.61e-01	8.70e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	9.15e-01	9.29e-01	0.130	-2.12e-02	-6.37e-02	8.73e-02	5.90e-02	2.71e-02	-0.025300	8.91e-01	6.80e-01	5.72e-01	7.02e-01	8.61e-01	8.70e-01
Carboxyterminal post-translational modifications of tubulin	33	7.78e-01	8.11e-01	0.129	2.38e-02	-5.60e-02	9.67e-02	1.41e-02	-4.66e-02	-0.034900	8.13e-01	5.78e-01	3.37e-01	8.89e-01	6.43e-01	7.29e-01
Signaling by NOTCH2	33	6.50e-01	6.94e-01	0.128	-5.53e-02	1.93e-02	5.05e-02	7.05e-02	3.96e-02	-0.062100	5.83e-01	8.48e-01	6.16e-01	4.83e-01	6.94e-01	5.37e-01
Sensory perception of taste	21	9.73e-01	9.77e-01	0.124	4.82e-02	7.25e-02	-3.13e-02	-4.05e-02	-2.67e-02	-0.066100	7.02e-01	5.65e-01	8.04e-01	7.48e-01	8.33e-01	6.00e-01
SLC-mediated transmembrane transport	171	9.84e-02	1.51e-01	0.116	-2.42e-02	-2.39e-03	6.99e-02	8.30e-02	-1.41e-02	0.027900	5.85e-01	9.57e-01	1.15e-01	6.11e-02	7.50e-01	5.29e-01
Phase I - Functionalization of compounds	60	7.04e-01	7.42e-01	0.115	-3.59e-02	-4.24e-02	-8.98e-03	-5.38e-02	2.95e-02	-0.078800	6.31e-01	5.70e-01	9.04e-01	4.71e-01	6.92e-01	2.91e-01
TAK1-dependent IKK and NF-kappa-B activation	43	8.27e-01	8.53e-01	0.112	-1.02e-01	3.00e-02	2.71e-02	-2.48e-03	2.22e-02	-0.001800	2.49e-01	7.34e-01	7.59e-01	9.78e-01	8.01e-01	9.84e-01

---

Detailed Gene set reports

Regulation of NFE2L2 gene expression

Regulation of NFE2L2 gene expression

metric	value
setSize	8
pMANOVA	5.25e-06
p.adjustMANOVA	2.66e-05
s.dist	1.37
s.crp_t0_adj	0.589
s.crp_eos_adj	0.643
s.crp_pod1_adj	0.594
s.avb_t0_adj	0.853
s.avb_eos_adj	0.162
s.avb_pod1_adj	-0.0422
p.crp_t0_adj	0.00391
p.crp_eos_adj	0.00164
p.crp_pod1_adj	0.00363
p.avb_t0_adj	2.95e-05
p.avb_eos_adj	0.428
p.avb_pod1_adj	0.836

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d4	d2
NOTCH1	10717	10316
NFKB1	10396	10187
CREBBP	9800	10039
EP300	9504	9857
RELA	10502	6020
MAFK	6807	4370
NFE2L2	7845	3778
MYC	8106	2541

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CREBBP	6238	10039	9002	9800	-4716	211
EP300	7113	9857	7992	9504	2793	18
MAFK	6860	4370	-92	6807	3982	-4073
MYC	9278	2541	8751	8106	-4148	4618
NFE2L2	45	3778	3371	7845	743	-737
NFKB1	9648	10187	4822	10396	7820	4643
NOTCH1	9237	10316	9149	10717	9360	1012
RELA	2071	6020	4255	10502	4556	-6049

---

---

Protein repair

Protein repair

metric	value
setSize	6
pMANOVA	0.0037
p.adjustMANOVA	0.00959
s.dist	1.35
s.crp_t0_adj	-0.513
s.crp_eos_adj	-0.471
s.crp_pod1_adj	0.386
s.avb_t0_adj	-0.454
s.avb_eos_adj	-0.744
s.avb_pod1_adj	0.646
p.crp_t0_adj	0.0295
p.crp_eos_adj	0.0456
p.crp_pod1_adj	0.101
p.avb_t0_adj	0.054
p.avb_eos_adj	0.00159
p.avb_pod1_adj	0.00611

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d5	d6
TXN	-8016	9385
MSRB3	-8426	8161
PCMT1	-6687	9631
MSRA	-5030	9627
MSRB1	-5907	7581

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
MSRA	-1424	-2043	-930	-3283	-5030	9627
MSRB1	737	2691	7462	672	-5907	7581
MSRB2	-7814	-7959	-4343	-8335	-7804	-1216
MSRB3	-4752	-9379	8005	-4088	-8426	8161
PCMT1	-9196	-4006	6197	-6076	-6687	9631
TXN	-9198	-6735	5973	-6072	-8016	9385

---

---

G2/M DNA replication checkpoint

G2/M DNA replication checkpoint

metric	value
setSize	5
pMANOVA	0.000362
p.adjustMANOVA	0.00123
s.dist	1.34
s.crp_t0_adj	-0.156
s.crp_eos_adj	-0.545
s.crp_pod1_adj	0.696
s.avb_t0_adj	0.416
s.avb_eos_adj	-0.603
s.avb_pod1_adj	0.674
p.crp_t0_adj	0.545
p.crp_eos_adj	0.0347
p.crp_pod1_adj	0.00706
p.avb_t0_adj	0.107
p.avb_eos_adj	0.0196
p.avb_pod1_adj	0.00903

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d3	d6
CDK1	8788	10765
CCNB1	7289	10032
CCNB2	5259	8940
PKMYT1	6434	4269
WEE1	7121	3433

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CCNB1	-5231	-7397	7289	2798	-4729	10032
CCNB2	5533	-8664	5259	7537	-5259	8940
CDK1	-3151	-6440	8788	9454	-2555	10765
PKMYT1	1010	-6601	6434	10103	-5574	4269
WEE1	-5795	2348	7121	-6779	-9318	3433

---

---

Interleukin-21 signaling

Interleukin-21 signaling

metric	value
setSize	9
pMANOVA	1.07e-05
p.adjustMANOVA	5.11e-05
s.dist	1.32
s.crp_t0_adj	0.243
s.crp_eos_adj	0.631
s.crp_pod1_adj	0.324
s.avb_t0_adj	0.707
s.avb_eos_adj	0.511
s.avb_pod1_adj	0.657
p.crp_t0_adj	0.207
p.crp_eos_adj	0.00105
p.crp_pod1_adj	0.0928
p.avb_t0_adj	0.000237
p.avb_eos_adj	0.00795
p.avb_pod1_adj	0.000647

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d4	d6
JAK3	10043	10547
IL21R	10358	10136
STAT3	10015	9798
JAK1	9178	9080
IL2RG	7215	7976
STAT4	5894	6484
STAT5B	5525	3303
STAT1	1356	10814

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
IL21R	10364	10570	9474	10358	11142	10136
IL2RG	10268	8206	-3560	7215	10146	7976
JAK1	-1543	8993	4148	9178	-922	9080
JAK3	10162	9089	10110	10043	4917	10547
STAT1	-34	2336	-2817	1356	9248	10814
STAT3	3376	7290	9778	10015	-5507	9798
STAT4	-3060	10104	-4469	5894	8217	6484
STAT5A	-971	-906	1695	9556	8898	-2429
STAT5B	-4531	7415	3235	5525	9818	3303

---

---

Response to metal ions

Response to metal ions

metric	value
setSize	6
pMANOVA	0.000642
p.adjustMANOVA	0.00202
s.dist	1.24
s.crp_t0_adj	0.224
s.crp_eos_adj	-0.439
s.crp_pod1_adj	0.777
s.avb_t0_adj	0.127
s.avb_eos_adj	-0.5
s.avb_pod1_adj	0.656
p.crp_t0_adj	0.342
p.crp_eos_adj	0.0625
p.crp_pod1_adj	0.000976
p.avb_t0_adj	0.591
p.avb_eos_adj	0.0338
p.avb_pod1_adj	0.00537

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d3	d6
MTF1	9647	8868
MT1X	9022	9443
MT2A	8747	5281
MT1E	8651	4877
CSRP1	5076	8280
MT1F	5871	7046

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CSRP1	269	-8842	5076	4423	-4466	8280
MT1E	3658	-8102	8651	-2731	-8864	4877
MT1F	5873	-4287	5871	2380	-5175	7046
MT1X	2467	-9473	9022	7315	-7750	9443
MT2A	10134	-5056	8747	3236	-9433	5281
MTF1	-7569	10355	9647	-5164	9206	8868

---

---

Formation of xylulose-5-phosphate

Formation of xylulose-5-phosphate

metric	value
setSize	5
pMANOVA	0.00431
p.adjustMANOVA	0.011
s.dist	1.24
s.crp_t0_adj	-0.565
s.crp_eos_adj	-0.599
s.crp_pod1_adj	-0.719
s.avb_t0_adj	0.0257
s.avb_eos_adj	0.551
s.avb_pod1_adj	-0.209
p.crp_t0_adj	0.0288
p.crp_eos_adj	0.0203
p.crp_pod1_adj	0.00537
p.avb_t0_adj	0.921
p.avb_eos_adj	0.0328
p.avb_pod1_adj	0.418

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d3	d2
XYLB	-10062	-8946
CRYL1	-9077	-8426
AKR1A1	-7171	-8841
DCXR	-6103	-9298

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
AKR1A1	-302	-8841	-7171	960	5917	-6249
CRYL1	-9560	-8426	-9077	-7512	6500	480
DCXR	-7399	-9298	-6103	6011	3004	2771
SORD	-7959	5918	-7051	4109	11049	-6317
XYLB	-3867	-8946	-10062	-990	6746	323

---

---

MECP2 regulates transcription of neuronal ligands

MECP2 regulates transcription of neuronal ligands

metric	value
setSize	5
pMANOVA	0.0247
p.adjustMANOVA	0.0482
s.dist	1.21
s.crp_t0_adj	0.289
s.crp_eos_adj	0.472
s.crp_pod1_adj	-0.109
s.avb_t0_adj	0.755
s.avb_eos_adj	0.726
s.avb_pod1_adj	0.234
p.crp_t0_adj	0.263
p.crp_eos_adj	0.0678
p.crp_pod1_adj	0.672
p.avb_t0_adj	0.00344
p.avb_eos_adj	0.0049
p.avb_pod1_adj	0.365

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d4	d5
HDAC1	9193	11070
MECP2	10446	9255
SIN3A	10484	8043
DLL1	9151	7591
CREB1	1667	6467

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CREB1	-8614	2791	-4296	1667	6467	4069
DLL1	10091	2685	789	9151	7591	6110
HDAC1	5951	2307	3131	9193	11070	8579
MECP2	5233	9029	-2506	10446	9255	-491
SIN3A	3132	9894	-4548	10484	8043	-3965

---

---

CD163 mediating an anti-inflammatory response

CD163 mediating an anti-inflammatory response

metric	value
setSize	8
pMANOVA	2.08e-07
p.adjustMANOVA	1.3e-06
s.dist	1.19
s.crp_t0_adj	-0.168
s.crp_eos_adj	0.0306
s.crp_pod1_adj	0.875
s.avb_t0_adj	-0.0382
s.avb_eos_adj	-0.784
s.avb_pod1_adj	-0.0578
p.crp_t0_adj	0.412
p.crp_eos_adj	0.881
p.crp_pod1_adj	1.8e-05
p.avb_t0_adj	0.852
p.avb_eos_adj	0.000122
p.avb_pod1_adj	0.777

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d3	d5
CD163	8603	-9662
ADAM17	9008	-9148
FURIN	9658	-8481
IL10	9654	-8357
RHBDF2	8262	-9071
MYH9	8518	-7695
PLK2	7226	-5292
MAPK14	9997	-1463

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
ADAM17	-9719	-5712	9008	-9318	-9148	912
CD163	-10095	-9779	8603	-10169	-9662	-8871
FURIN	-709	5808	9658	8793	-8481	268
IL10	7100	10073	9654	3351	-8357	992
MAPK14	-9140	10226	9997	209	-1463	10530
MYH9	700	1973	8518	7787	-7695	6358
PLK2	3275	-2674	7226	-6635	-5292	-8467
RHBDF2	5446	-4278	8262	4733	-9071	-3388

---

---

Defective binding of VWF variant to GPIb:IX:V

Defective binding of VWF variant to GPIb:IX:V

metric	value
setSize	5
pMANOVA	0.000713
p.adjustMANOVA	0.00221
s.dist	1.18
s.crp_t0_adj	0.413
s.crp_eos_adj	-0.707
s.crp_pod1_adj	0.328
s.avb_t0_adj	-0.282
s.avb_eos_adj	-0.725
s.avb_pod1_adj	0.121
p.crp_t0_adj	0.11
p.crp_eos_adj	0.00616
p.crp_pod1_adj	0.204
p.avb_t0_adj	0.275
p.avb_eos_adj	0.00498
p.avb_pod1_adj	0.639

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d5	d2
GP9	-8955	-9687
GP1BB	-8335	-9570
VWF	-7952	-8776
GP1BA	-6774	-6711
GP5	-1865	-528

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
GP1BA	8110	-6711	3557	-2557	-6774	-7240
GP1BB	6835	-9570	3904	-3787	-8335	5258
GP5	7429	-528	1605	3950	-1865	5276
GP9	4949	-9687	5296	-6915	-8955	1304
VWF	-5023	-8776	1186	-4282	-7952	3772

---

---

Enhanced binding of GP1BA variant to VWF multimer:collagen

Enhanced binding of GP1BA variant to VWF multimer:collagen

metric	value
setSize	5
pMANOVA	0.000713
p.adjustMANOVA	0.00221
s.dist	1.18
s.crp_t0_adj	0.413
s.crp_eos_adj	-0.707
s.crp_pod1_adj	0.328
s.avb_t0_adj	-0.282
s.avb_eos_adj	-0.725
s.avb_pod1_adj	0.121
p.crp_t0_adj	0.11
p.crp_eos_adj	0.00616
p.crp_pod1_adj	0.204
p.avb_t0_adj	0.275
p.avb_eos_adj	0.00498
p.avb_pod1_adj	0.639

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d5	d2
GP9	-8955	-9687
GP1BB	-8335	-9570
VWF	-7952	-8776
GP1BA	-6774	-6711
GP5	-1865	-528

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
GP1BA	8110	-6711	3557	-2557	-6774	-7240
GP1BB	6835	-9570	3904	-3787	-8335	5258
GP5	7429	-528	1605	3950	-1865	5276
GP9	4949	-9687	5296	-6915	-8955	1304
VWF	-5023	-8776	1186	-4282	-7952	3772

---

---

SUMO is conjugated to E1 (UBA2:SAE1)

SUMO is conjugated to E1 (UBA2:SAE1)

metric	value
setSize	5
pMANOVA	0.0167
p.adjustMANOVA	0.0346
s.dist	1.16
s.crp_t0_adj	-0.669
s.crp_eos_adj	-0.738
s.crp_pod1_adj	-0.237
s.avb_t0_adj	-0.00341
s.avb_eos_adj	-0.366
s.avb_pod1_adj	0.409
p.crp_t0_adj	0.00956
p.crp_eos_adj	0.00425
p.crp_pod1_adj	0.359
p.avb_t0_adj	0.989
p.avb_eos_adj	0.157
p.avb_pod1_adj	0.113

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d1
SUMO2	-7758	-7463
UBA2	-7027	-7996
SAE1	-9688	-5228
SUMO1	-4939	-9534
SUMO3	-7485	-4360

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
SAE1	-5228	-9688	-6183	8428	-6304	2211
SUMO1	-9534	-4939	3748	-669	1591	9997
SUMO2	-7463	-7758	-6535	-5700	-510	7226
SUMO3	-4360	-7485	-1098	4220	-3108	2213
UBA2	-7996	-7027	-4074	-5231	-6654	1871

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	99
pMANOVA	7.5e-58
p.adjustMANOVA	7.58e-56
s.dist	1.16
s.crp_t0_adj	-0.257
s.crp_eos_adj	-0.848
s.crp_pod1_adj	-0.683
s.avb_t0_adj	-0.113
s.avb_eos_adj	-0.0326
s.avb_pod1_adj	-0.267
p.crp_t0_adj	1.02e-05
p.crp_eos_adj	2.07e-48
p.crp_pod1_adj	5.66e-32
p.avb_t0_adj	0.0516
p.avb_eos_adj	0.575
p.avb_pod1_adj	4.42e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
EIF3L	-8972	-10506
EIF3E	-9493	-9929
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
FAU	-307	-8617	-7795	3589	-499	-4729
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

metric	value
setSize	5
pMANOVA	0.0406
p.adjustMANOVA	0.0737
s.dist	1.16
s.crp_t0_adj	0.496
s.crp_eos_adj	0.531
s.crp_pod1_adj	0.484
s.avb_t0_adj	0.355
s.avb_eos_adj	0.0976
s.avb_pod1_adj	0.66
p.crp_t0_adj	0.0548
p.crp_eos_adj	0.0396
p.crp_pod1_adj	0.0607
p.avb_t0_adj	0.169
p.avb_eos_adj	0.705
p.avb_pod1_adj	0.0106

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d6	d2
KREMEN1	8230	7635
LRP5	10156	4965
LRP6	9406	4065
WNT4	7362	5046
KREMEN2	1526	8139

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
KREMEN1	10416	7635	10096	-1436	-3575	8230
KREMEN2	4811	8139	-3520	8566	4020	1526
LRP5	8914	4965	9962	9275	-67	10156
LRP6	-4291	4065	-2248	3443	9387	9406
WNT4	6813	5046	9498	67	-395	7362

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	87
pMANOVA	1.23e-51
p.adjustMANOVA	1.02e-49
s.dist	1.15
s.crp_t0_adj	-0.23
s.crp_eos_adj	-0.85
s.crp_pod1_adj	-0.681
s.avb_t0_adj	-0.11
s.avb_eos_adj	-0.00325
s.avb_pod1_adj	-0.273
p.crp_t0_adj	0.000208
p.crp_eos_adj	6.93e-43
p.crp_pod1_adj	4.4e-28
p.avb_t0_adj	0.0765
p.avb_eos_adj	0.958
p.avb_pod1_adj	1.06e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
EEF1A1	-9339	-10184
RPL29	-9652	-9844
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EEF1A1	-7903	-9339	-10184	-4180	1634	-5310
EEF2	-5679	-6915	-9722	1088	-550	-8735
FAU	-307	-8617	-7795	3589	-499	-4729
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	92
pMANOVA	1.27e-53
p.adjustMANOVA	1.22e-51
s.dist	1.13
s.crp_t0_adj	-0.215
s.crp_eos_adj	-0.841
s.crp_pod1_adj	-0.669
s.avb_t0_adj	-0.103
s.avb_eos_adj	0.000647
s.avb_pod1_adj	-0.264
p.crp_t0_adj	0.000364
p.crp_eos_adj	2.38e-44
p.crp_pod1_adj	1.27e-28
p.avb_t0_adj	0.0873
p.avb_eos_adj	0.991
p.avb_pod1_adj	1.22e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
EEF1A1	-9339	-10184
RPL29	-9652	-9844
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EEF1A1	-7903	-9339	-10184	-4180	1634	-5310
EEF1A1P5	-6632	-8493	-9311	3073	2189	-1589
EEF1A2	9391	-103	4387	-938	-334	3206
EEF1B2	-2826	-9241	-7973	-3209	4140	-1733
EEF1D	5859	-7186	-6086	4063	328	-2708
EEF1G	-2715	-8875	-6647	-992	1501	-350
EEF2	-5679	-6915	-9722	1088	-550	-8735
FAU	-307	-8617	-7795	3589	-499	-4729
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Tandem pore domain potassium channels

Tandem pore domain potassium channels

metric	value
setSize	5
pMANOVA	0.00328
p.adjustMANOVA	0.00865
s.dist	1.12
s.crp_t0_adj	-0.274
s.crp_eos_adj	0.467
s.crp_pod1_adj	0.365
s.avb_t0_adj	0.424
s.avb_eos_adj	0.684
s.avb_pod1_adj	0.432
p.crp_t0_adj	0.288
p.crp_eos_adj	0.0706
p.crp_pod1_adj	0.158
p.avb_t0_adj	0.1
p.avb_eos_adj	0.00809
p.avb_pod1_adj	0.0941

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d5	d2
KCNK13	6361	10451
KCNK10	10803	5732
KCNK7	4052	10025
KCNK17	8015	1594

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
KCNK10	-5432	5732	8357	4717	10803	10770
KCNK13	-8283	10451	9525	6120	6361	9517
KCNK17	-2671	1594	62	2686	8015	10637
KCNK6	-848	-1342	-8730	5877	10957	2256
KCNK7	3406	10025	8277	4142	4052	-8455

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	87
pMANOVA	4.37e-49
p.adjustMANOVA	3e-47
s.dist	1.12
s.crp_t0_adj	-0.236
s.crp_eos_adj	-0.838
s.crp_pod1_adj	-0.655
s.avb_t0_adj	-0.113
s.avb_eos_adj	-0.0178
s.avb_pod1_adj	-0.242
p.crp_t0_adj	0.000144
p.crp_eos_adj	9.14e-42
p.crp_pod1_adj	4.1e-26
p.avb_t0_adj	0.0676
p.avb_eos_adj	0.775
p.avb_pod1_adj	9.39e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137
RPL15	-9523	-8791

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
DNAJC3	-10118	3479	9870	1788	-6914	9880
FAU	-307	-8617	-7795	3589	-499	-4729
GRSF1	-8594	-9170	-6295	-8071	-5227	4285
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	109
pMANOVA	1.4e-58
p.adjustMANOVA	1.58e-56
s.dist	1.12
s.crp_t0_adj	-0.289
s.crp_eos_adj	-0.831
s.crp_pod1_adj	-0.64
s.avb_t0_adj	-0.132
s.avb_eos_adj	-0.0703
s.avb_pod1_adj	-0.227
p.crp_t0_adj	1.77e-07
p.crp_eos_adj	4.72e-51
p.crp_pod1_adj	7.21e-31
p.avb_t0_adj	0.0175
p.avb_eos_adj	0.205
p.avb_pod1_adj	4.2e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
EIF3L	-8972	-10506
EIF3E	-9493	-9929
PABPC1	-9229	-10178
RPL4	-9745	-9578
RPL7	-9819	-9495
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
FAU	-307	-8617	-7795	3589	-499	-4729
PABPC1	-9924	-9229	-10178	-1450	-1281	2182
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

MET activates PI3K/AKT signaling

MET activates PI3K/AKT signaling

metric	value
setSize	5
pMANOVA	0.00238
p.adjustMANOVA	0.00647
s.dist	1.12
s.crp_t0_adj	-0.446
s.crp_eos_adj	0.591
s.crp_pod1_adj	0.49
s.avb_t0_adj	-0.237
s.avb_eos_adj	-0.436
s.avb_pod1_adj	0.458
p.crp_t0_adj	0.0841
p.crp_eos_adj	0.0221
p.crp_pod1_adj	0.0578
p.avb_t0_adj	0.358
p.avb_eos_adj	0.0912
p.avb_pod1_adj	0.0762

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d2	d3
HGF	8640	8488
PIK3R1	10317	5017
PIK3CA	6653	5409

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
GAB1	-3376	7647	-870	-5568	-8351	-3093
GRB2	-8480	-276	6035	-820	-1924	4438
HGF	-4080	8640	8488	-8418	-8455	10382
PIK3CA	-5737	6653	5409	1360	4068	8795
PIK3R1	-1187	10317	5017	2193	-4031	5544

---

---

Type I hemidesmosome assembly

Type I hemidesmosome assembly

metric	value
setSize	8
pMANOVA	0.0024
p.adjustMANOVA	0.00652
s.dist	1.11
s.crp_t0_adj	0.184
s.crp_eos_adj	0.357
s.crp_pod1_adj	0.569
s.avb_t0_adj	0.594
s.avb_eos_adj	0.275
s.avb_pod1_adj	0.574
p.crp_t0_adj	0.368
p.crp_eos_adj	0.0805
p.crp_pod1_adj	0.00535
p.avb_t0_adj	0.00359
p.avb_eos_adj	0.178
p.avb_pod1_adj	0.00493

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d4	d6
KRT5	10525	10915
LAMB3	9554	10831
ITGA6	5773	9594
COL17A1	5023	9132
DST	9290	4219
ITGB4	7260	5135
PLEC	8231	523

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CD151	-1118	-5763	3719	-3698	-4304	1120
COL17A1	363	6832	8998	5023	-3017	9132
DST	5676	8578	-3787	9290	11308	4219
ITGA6	3545	10163	9670	5773	1766	9594
ITGB4	7231	1058	61	7260	9775	5135
KRT5	-1889	5611	7975	10525	11269	10915
LAMB3	-5967	-211	10048	9554	10082	10831
PLEC	8569	6798	8448	8231	-6988	523

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	110
pMANOVA	4.14e-58
p.adjustMANOVA	4.41e-56
s.dist	1.11
s.crp_t0_adj	-0.288
s.crp_eos_adj	-0.827
s.crp_pod1_adj	-0.627
s.avb_t0_adj	-0.137
s.avb_eos_adj	-0.0695
s.avb_pod1_adj	-0.222
p.crp_t0_adj	1.77e-07
p.crp_eos_adj	5.92e-51
p.crp_pod1_adj	5.23e-30
p.avb_t0_adj	0.0132
p.avb_eos_adj	0.208
p.avb_pod1_adj	5.62e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
EIF3L	-8972	-10506
EIF3E	-9493	-9929
RPL4	-9745	-9578
RPL7	-9819	-9495
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
EIF5	-10136	-8192	-1813	-5537	-2061	-1505
EIF5B	-1210	-4022	-1173	-2906	1825	7209
FAU	-307	-8617	-7795	3589	-499	-4729
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Modulation by Mtb of host immune system

Modulation by Mtb of host immune system

metric	value
setSize	7
pMANOVA	0.0111
p.adjustMANOVA	0.0245
s.dist	1.11
s.crp_t0_adj	-0.433
s.crp_eos_adj	-0.823
s.crp_pod1_adj	-0.328
s.avb_t0_adj	-0.143
s.avb_eos_adj	-0.486
s.avb_pod1_adj	0.0329
p.crp_t0_adj	0.0473
p.crp_eos_adj	0.000164
p.crp_pod1_adj	0.133
p.avb_t0_adj	0.512
p.avb_eos_adj	0.0261
p.avb_pod1_adj	0.88

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d5
UBC	-9557	-7895
TLR2	-7197	-9582
MRC1	-7904	-6945
B2M	-9924	-5339
UBA52	-9138	-3439
UBB	-5392	-139

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
B2M	-9787	-9924	-9859	-3506	-5339	5049
MRC1	-3997	-7904	5038	8840	-6945	873
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
TLR2	-10296	-7197	-3205	-10181	-9582	-3565
UBA52	-2556	-9138	-8674	-1579	-3439	-4257
UBB	8771	-5392	442	6104	-139	4805
UBC	-9037	-9557	-1562	-4448	-7895	4268

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	91
pMANOVA	2.18e-49
p.adjustMANOVA	1.67e-47
s.dist	1.11
s.crp_t0_adj	-0.229
s.crp_eos_adj	-0.811
s.crp_pod1_adj	-0.663
s.avb_t0_adj	-0.0895
s.avb_eos_adj	0.00351
s.avb_pod1_adj	-0.258
p.crp_t0_adj	0.000164
p.crp_eos_adj	6.76e-41
p.crp_pod1_adj	6.47e-28
p.avb_t0_adj	0.14
p.avb_eos_adj	0.954
p.avb_pod1_adj	2.17e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137
RPL15	-9523	-8791

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EEFSEC	-7327	-8156	-5902	5822	129	-6508
FAU	-307	-8617	-7795	3589	-499	-4729
PSTK	596	-114	-6930	-179	1703	-1005
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
SARS1	-5180	-6648	-6233	3800	2019	-264
SECISBP2	-3891	-1702	-9271	-2065	3209	-4003
SEPHS2	392	1542	4023	10082	805	8065
SEPSECS	-5825	2121	-8966	-4752	2914	-5200
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

metric	value
setSize	36
pMANOVA	8.89e-19
p.adjustMANOVA	1.54e-17
s.dist	1.1
s.crp_t0_adj	-0.198
s.crp_eos_adj	-0.816
s.crp_pod1_adj	-0.655
s.avb_t0_adj	-0.122
s.avb_eos_adj	-0.0175
s.avb_pod1_adj	-0.266
p.crp_t0_adj	0.04
p.crp_eos_adj	2.26e-17
p.crp_pod1_adj	1.04e-11
p.avb_t0_adj	0.204
p.avb_eos_adj	0.856
p.avb_pod1_adj	0.00575

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
EEF1A1	-9339	-10184
RPS3A	-9728	-9449
RPS7	-9828	-9245
RPS20	-9658	-9149
RPS3	-9159	-9204
RPS11	-8989	-8781
RPS25	-9637	-8163
RPS24	-9539	-8118
RPS10	-8920	-8524
RPS27A	-8742	-8642
RPS6	-9462	-7590
RPS8	-9563	-7489
RPS15A	-9501	-7169
FAU	-8617	-7795
RPS23	-9376	-7077
RPS27L	-8401	-7829
RPS4Y1	-6839	-9414
RPS14	-7774	-8249

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EEF1A1	-7903	-9339	-10184	-4180	1634	-5310
FAU	-307	-8617	-7795	3589	-499	-4729
HNRNPA1	-6635	-8677	-7160	-5716	-3680	-1338
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804

---

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

metric	value
setSize	51
pMANOVA	2.16e-25
p.adjustMANOVA	4.45e-24
s.dist	1.1
s.crp_t0_adj	-0.281
s.crp_eos_adj	-0.809
s.crp_pod1_adj	-0.642
s.avb_t0_adj	-0.142
s.avb_eos_adj	-0.0844
s.avb_pod1_adj	-0.215
p.crp_t0_adj	0.000528
p.crp_eos_adj	1.4e-23
p.crp_pod1_adj	2.13e-15
p.avb_t0_adj	0.0804
p.avb_eos_adj	0.297
p.avb_pod1_adj	0.00791

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
EIF3L	-8972	-10506
EIF3E	-9493	-9929
RPS3A	-9728	-9449
RPS7	-9828	-9245
RPS20	-9658	-9149
RPS3	-9159	-9204
EIF3K	-9403	-8817
EIF3H	-9541	-8402
RPS11	-8989	-8781
RPS25	-9637	-8163
RPS24	-9539	-8118
EIF3G	-8614	-8858
RPS10	-8920	-8524
RPS27A	-8742	-8642
EIF3D	-8726	-8591
RPS6	-9462	-7590
RPS8	-9563	-7489

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
FAU	-307	-8617	-7795	3589	-499	-4729
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804

---

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

metric	value
setSize	117
pMANOVA	3.54e-61
p.adjustMANOVA	4.25e-59
s.dist	1.1
s.crp_t0_adj	-0.279
s.crp_eos_adj	-0.821
s.crp_pod1_adj	-0.623
s.avb_t0_adj	-0.13
s.avb_eos_adj	-0.0612
s.avb_pod1_adj	-0.23
p.crp_t0_adj	1.82e-07
p.crp_eos_adj	2.52e-53
p.crp_pod1_adj	1.96e-31
p.avb_t0_adj	0.0153
p.avb_eos_adj	0.253
p.avb_pod1_adj	1.73e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
EIF4EBP1	-9839	-9862
RPL29	-9652	-9844
EIF3L	-8972	-10506
EIF3E	-9493	-9929
PABPC1	-9229	-10178
RPL4	-9745	-9578
RPL7	-9819	-9495
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2B1	-3010	-8459	-10113	-2026	7965	-8148
EIF2B2	-1827	-8703	2531	4635	-2635	4393
EIF2B3	-3856	-5761	-4297	-2567	7397	5547
EIF2B4	8703	-5210	-6155	2141	-3582	-8034
EIF2B5	7805	-2989	-5212	5927	4298	-9317
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4EBP1	-7043	-9839	-9862	-6367	-1139	-9377
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
EIF5	-10136	-8192	-1813	-5537	-2061	-1505
EIF5B	-1210	-4022	-1173	-2906	1825	7209
FAU	-307	-8617	-7795	3589	-499	-4729
PABPC1	-9924	-9229	-10178	-1450	-1281	2182
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

metric	value
setSize	117
pMANOVA	3.54e-61
p.adjustMANOVA	4.25e-59
s.dist	1.1
s.crp_t0_adj	-0.279
s.crp_eos_adj	-0.821
s.crp_pod1_adj	-0.623
s.avb_t0_adj	-0.13
s.avb_eos_adj	-0.0612
s.avb_pod1_adj	-0.23
p.crp_t0_adj	1.82e-07
p.crp_eos_adj	2.52e-53
p.crp_pod1_adj	1.96e-31
p.avb_t0_adj	0.0153
p.avb_eos_adj	0.253
p.avb_pod1_adj	1.73e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
EIF4EBP1	-9839	-9862
RPL29	-9652	-9844
EIF3L	-8972	-10506
EIF3E	-9493	-9929
PABPC1	-9229	-10178
RPL4	-9745	-9578
RPL7	-9819	-9495
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2B1	-3010	-8459	-10113	-2026	7965	-8148
EIF2B2	-1827	-8703	2531	4635	-2635	4393
EIF2B3	-3856	-5761	-4297	-2567	7397	5547
EIF2B4	8703	-5210	-6155	2141	-3582	-8034
EIF2B5	7805	-2989	-5212	5927	4298	-9317
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4EBP1	-7043	-9839	-9862	-6367	-1139	-9377
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
EIF5	-10136	-8192	-1813	-5537	-2061	-1505
EIF5B	-1210	-4022	-1173	-2906	1825	7209
FAU	-307	-8617	-7795	3589	-499	-4729
PABPC1	-9924	-9229	-10178	-1450	-1281	2182
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Phosphate bond hydrolysis by NUDT proteins

Phosphate bond hydrolysis by NUDT proteins

metric	value
setSize	7
pMANOVA	0.02
p.adjustMANOVA	0.0401
s.dist	1.1
s.crp_t0_adj	-0.59
s.crp_eos_adj	-0.745
s.crp_pod1_adj	-0.433
s.avb_t0_adj	-0.257
s.avb_eos_adj	-0.231
s.avb_pod1_adj	-0.0153
p.crp_t0_adj	0.00688
p.crp_eos_adj	0.000638
p.crp_pod1_adj	0.0473
p.avb_t0_adj	0.239
p.avb_eos_adj	0.291
p.avb_pod1_adj	0.944

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d1
NUDT16	-9908	-10293
NUDT15	-8372	-10367
ADPRM	-9550	-8228
NUDT5	-6935	-9621
NUDT9	-1760	-7866

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
ADPRM	-8228	-9550	-8422	-1043	-7917	4860
NUDT1	1030	-9042	-8697	7643	6134	-5523
NUDT15	-10367	-8372	-9945	-8857	-5422	-1528
NUDT16	-10293	-9908	-1484	-10216	-9666	-4275
NUDT18	2766	-6596	-4280	-794	1307	4612
NUDT5	-9621	-6935	-6707	-1544	-4150	3283
NUDT9	-7866	-1760	5324	-2381	8677	242

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	91
pMANOVA	2.42e-49
p.adjustMANOVA	1.72e-47
s.dist	1.1
s.crp_t0_adj	-0.22
s.crp_eos_adj	-0.816
s.crp_pod1_adj	-0.652
s.avb_t0_adj	-0.0855
s.avb_eos_adj	-0.00298
s.avb_pod1_adj	-0.242
p.crp_t0_adj	0.000284
p.crp_eos_adj	2.01e-41
p.crp_pod1_adj	5.47e-27
p.avb_t0_adj	0.159
p.avb_eos_adj	0.961
p.avb_pod1_adj	6.79e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137
RPL15	-9523	-8791

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
APEH	-3460	-7853	-5896	5121	-870	-4346
ETF1	-10271	-2236	1844	-1393	-4296	2806
FAU	-307	-8617	-7795	3589	-499	-4729
GSPT1	6043	-2598	2463	3739	-8204	4931
GSPT2	-2408	-1588	-4149	4013	6238	7998
N6AMT1	1646	5023	-9534	3134	8617	-4648
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
TRMT112	-4789	-8852	-6781	1924	3113	-462
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

POLB-Dependent Long Patch Base Excision Repair

POLB-Dependent Long Patch Base Excision Repair

metric	value
setSize	8
pMANOVA	0.00194
p.adjustMANOVA	0.00542
s.dist	1.09
s.crp_t0_adj	0.16
s.crp_eos_adj	-0.259
s.crp_pod1_adj	-0.57
s.avb_t0_adj	0.659
s.avb_eos_adj	0.552
s.avb_pod1_adj	-0.161
p.crp_t0_adj	0.433
p.crp_eos_adj	0.204
p.crp_pod1_adj	0.0052
p.avb_t0_adj	0.00125
p.avb_eos_adj	0.00682
p.avb_pod1_adj	0.431

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d4	d3
FEN1	10644	-8527
ADPRS	9972	-6645
PARP2	5799	-10734
LIG1	6228	-8278
APEX1	4476	-10659
POLB	4525	-7875
PARP1	9582	-2209

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
ADPRS	1927	-6117	-6645	9972	2589	1423
APEX1	-3430	-9145	-10659	4476	7328	-8000
FEN1	9471	-4875	-8527	10644	3940	-2118
LIG1	8305	832	-8278	6228	9532	-9198
PARG	-5755	3769	4268	6158	9904	5043
PARP1	4648	-1594	-2209	9582	-975	2708
PARP2	7969	-858	-10734	5799	10063	-10002
POLB	-8732	-763	-7875	4525	10850	9812

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	93
pMANOVA	6.12e-48
p.adjustMANOVA	3.79e-46
s.dist	1.08
s.crp_t0_adj	-0.229
s.crp_eos_adj	-0.808
s.crp_pod1_adj	-0.634
s.avb_t0_adj	-0.0859
s.avb_eos_adj	-0.037
s.avb_pod1_adj	-0.244
p.crp_t0_adj	0.000137
p.crp_eos_adj	1.72e-41
p.crp_pod1_adj	3.72e-26
p.avb_t0_adj	0.152
p.avb_eos_adj	0.537
p.avb_pod1_adj	4.64e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
PABPC1	-9229	-10178
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF4G1	1507	739	9083	10566	-8323	-2261
ETF1	-10271	-2236	1844	-1393	-4296	2806
FAU	-307	-8617	-7795	3589	-499	-4729
GSPT1	6043	-2598	2463	3739	-8204	4931
GSPT2	-2408	-1588	-4149	4013	6238	7998
NCBP1	-4403	-1825	-6270	-2540	-2883	-1755
NCBP2	-8636	-7612	-10360	-7760	-1917	-9675
PABPC1	-9924	-9229	-10178	-1450	-1281	2182
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
UBA52	-2556	-9138	-8674	-1579	-3439	-4257
UPF1	2086	-2133	-1555	9636	-6271	-4872

---

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

metric	value
setSize	59
pMANOVA	6.42e-27
p.adjustMANOVA	1.45e-25
s.dist	1.08
s.crp_t0_adj	-0.325
s.crp_eos_adj	-0.793
s.crp_pod1_adj	-0.596
s.avb_t0_adj	-0.155
s.avb_eos_adj	-0.134
s.avb_pod1_adj	-0.206
p.crp_t0_adj	1.53e-05
p.crp_eos_adj	5.37e-26
p.crp_pod1_adj	2.33e-15
p.avb_t0_adj	0.0391
p.avb_eos_adj	0.076
p.avb_pod1_adj	0.0061

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
EIF4EBP1	-9839	-9862
EIF3L	-8972	-10506
EIF3E	-9493	-9929
PABPC1	-9229	-10178
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPS7	-9828	-9245
RPS20	-9658	-9149
RPS3	-9159	-9204
EIF3K	-9403	-8817
EIF3H	-9541	-8402
RPS11	-8989	-8781
RPS25	-9637	-8163
RPS24	-9539	-8118
EIF3G	-8614	-8858
RPS10	-8920	-8524
RPS27A	-8742	-8642

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4EBP1	-7043	-9839	-9862	-6367	-1139	-9377
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
FAU	-307	-8617	-7795	3589	-499	-4729
PABPC1	-9924	-9229	-10178	-1450	-1281	2182
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804

---

---

Translation initiation complex formation

Translation initiation complex formation

metric	value
setSize	58
pMANOVA	4.05e-26
p.adjustMANOVA	8.93e-25
s.dist	1.07
s.crp_t0_adj	-0.319
s.crp_eos_adj	-0.79
s.crp_pod1_adj	-0.59
s.avb_t0_adj	-0.147
s.avb_eos_adj	-0.133
s.avb_pod1_adj	-0.194
p.crp_t0_adj	2.59e-05
p.crp_eos_adj	2.16e-25
p.crp_pod1_adj	7.05e-15
p.avb_t0_adj	0.0527
p.avb_eos_adj	0.0807
p.avb_pod1_adj	0.0107

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
EIF3L	-8972	-10506
EIF3E	-9493	-9929
PABPC1	-9229	-10178
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPS7	-9828	-9245
RPS20	-9658	-9149
RPS3	-9159	-9204
EIF3K	-9403	-8817
EIF3H	-9541	-8402
RPS11	-8989	-8781
RPS25	-9637	-8163
RPS24	-9539	-8118
EIF3G	-8614	-8858
RPS10	-8920	-8524
RPS27A	-8742	-8642
EIF3D	-8726	-8591

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
FAU	-307	-8617	-7795	3589	-499	-4729
PABPC1	-9924	-9229	-10178	-1450	-1281	2182
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804

---

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

metric	value
setSize	58
pMANOVA	1.15e-25
p.adjustMANOVA	2.42e-24
s.dist	1.07
s.crp_t0_adj	-0.32
s.crp_eos_adj	-0.788
s.crp_pod1_adj	-0.577
s.avb_t0_adj	-0.154
s.avb_eos_adj	-0.134
s.avb_pod1_adj	-0.2
p.crp_t0_adj	2.54e-05
p.crp_eos_adj	2.74e-25
p.crp_pod1_adj	2.91e-14
p.avb_t0_adj	0.0427
p.avb_eos_adj	0.0779
p.avb_pod1_adj	0.00844

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
EIF3M	-10013	-10530
RPS13	-9834	-9986
RPS4X	-9724	-10093
EIF3L	-8972	-10506
EIF3E	-9493	-9929
EIF4B	-8995	-10271
RPS3A	-9728	-9449
RPS7	-9828	-9245
RPS20	-9658	-9149
RPS3	-9159	-9204
EIF3K	-9403	-8817
EIF3H	-9541	-8402
RPS11	-8989	-8781
RPS25	-9637	-8163
RPS24	-9539	-8118
EIF3G	-8614	-8858
RPS10	-8920	-8524
RPS27A	-8742	-8642
EIF3D	-8726	-8591
RPS6	-9462	-7590

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
EIF1AX	-8886	-6145	-4195	-7317	-4997	3159
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
EIF3A	-6555	-6532	-5661	3892	-2067	-1004
EIF3B	2442	-8019	-7890	5467	-5432	-9464
EIF3C	-91	-6910	-7679	6610	5977	-4926
EIF3D	-3648	-8726	-8591	413	-386	-2324
EIF3E	-9652	-9493	-9929	-7421	-454	-1968
EIF3F	-2465	-6438	-8899	-1946	3572	-7920
EIF3G	1955	-8614	-8858	659	-1485	-7542
EIF3H	-8189	-9541	-8402	-7090	-2343	-1930
EIF3I	-5272	-9182	-5901	-583	-2761	1841
EIF3J	-7172	-8539	-6153	-359	-5731	8956
EIF3K	-2840	-9403	-8817	2867	-829	-3943
EIF3L	-7983	-8972	-10506	-4780	915	-6963
EIF3M	-10102	-10013	-10530	-7758	-3580	-2925
EIF4A1	-6051	-8877	-6399	-4401	-5881	-8116
EIF4A2	-3658	-5014	-6118	-7889	-1630	554
EIF4B	-9518	-8995	-10271	-5522	-2697	-2456
EIF4E	-6052	-4841	7683	-6222	-6003	9479
EIF4G1	1507	739	9083	10566	-8323	-2261
EIF4H	-9587	-8396	-1985	2878	-3749	510
EIF5	-10136	-8192	-1813	-5537	-2061	-1505
FAU	-307	-8617	-7795	3589	-499	-4729
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804

---

---

Fructose metabolism

Fructose metabolism

metric	value
setSize	7
pMANOVA	0.00723
p.adjustMANOVA	0.0171
s.dist	1.06
s.crp_t0_adj	-0.275
s.crp_eos_adj	-0.226
s.crp_pod1_adj	-0.579
s.avb_t0_adj	-0.14
s.avb_eos_adj	0.388
s.avb_pod1_adj	-0.703
p.crp_t0_adj	0.208
p.crp_eos_adj	0.301
p.crp_pod1_adj	0.00796
p.avb_t0_adj	0.521
p.avb_eos_adj	0.0755
p.avb_pod1_adj	0.00128

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d6	d3
ALDH1A1	-10085	-10851
TKFC	-9936	-10624
AKR1B1	-9492	-10785
KHK	-9178	-10511
SORD	-6317	-7051

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
AKR1B1	-5430	-8466	-10785	1978	5204	-9492
ALDH1A1	-4671	773	-10851	-6603	8961	-10085
ALDOB	-3621	2211	2348	-7480	583	66
GLYCTK	8982	224	2505	4328	-3509	-3996
KHK	-5902	-8572	-10511	-4196	8330	-9178
SORD	-7959	5918	-7051	4109	11049	-6317
TKFC	-782	-6026	-10624	-719	3858	-9936

---

---

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

metric	value
setSize	6
pMANOVA	0.0286
p.adjustMANOVA	0.0547
s.dist	1.05
s.crp_t0_adj	0.0662
s.crp_eos_adj	0.221
s.crp_pod1_adj	0.817
s.avb_t0_adj	0.127
s.avb_eos_adj	-0.0167
s.avb_pod1_adj	0.61
p.crp_t0_adj	0.779
p.crp_eos_adj	0.349
p.crp_pod1_adj	0.000529
p.avb_t0_adj	0.589
p.avb_eos_adj	0.944
p.avb_pod1_adj	0.00964

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d3	d6
H19	9837	10890
IGF2BP3	9711	10797
CD44	8592	10568
ACTB	7523	7306
MYC	8751	4618

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
ACTB	1836	6408	7523	8061	1685	7306
CD44	-5979	5422	8592	-7094	9104	10568
H19	6122	10153	9837	5183	3976	10890
IGF2BP2	2844	-3698	5102	-2048	-5066	-3293
IGF2BP3	-9214	-4615	9711	-2707	-1519	10797
MYC	9278	2541	8751	8106	-4148	4618

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	110
pMANOVA	6.87e-53
p.adjustMANOVA	6.27e-51
s.dist	1.05
s.crp_t0_adj	-0.314
s.crp_eos_adj	-0.81
s.crp_pod1_adj	-0.561
s.avb_t0_adj	-0.0984
s.avb_eos_adj	-0.104
s.avb_pod1_adj	-0.0969
p.crp_t0_adj	1.3e-08
p.crp_eos_adj	5.61e-49
p.crp_pod1_adj	2.56e-24
p.avb_t0_adj	0.0745
p.avb_eos_adj	0.0587
p.avb_pod1_adj	0.079

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
SEC11A	-9803	-10401
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
SSR2	-9507	-9852
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
DDOST	-8930	-8701	-1142	3049	-3395	5377
FAU	-307	-8617	-7795	3589	-499	-4729
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPN1	-6748	-8935	4327	6051	-7877	6275
RPN2	-9385	-8855	7309	1263	-5893	6994
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
SEC11A	-9636	-9803	-10401	-5100	5650	549
SEC11C	-5740	-8741	-7142	-1948	-6159	7249
SEC61A1	-7699	-7801	-637	871	-7627	3520
SEC61A2	-3281	4413	-6570	37	-971	-966
SEC61B	-4835	-7705	-3103	917	-6209	2833
SEC61G	-8352	-8141	-3426	-425	-6513	5441
SPCS1	-6283	-9620	-6320	-4686	-5517	5813
SPCS2	-6412	-6756	3513	160	-6402	10097
SPCS3	-9898	-2908	1178	-4946	-5940	6015
SRP14	-3094	-9001	1480	1373	472	9070
SRP19	-2682	-4054	2331	-1158	-3924	9442
SRP54	-2543	-957	6814	-636	-2747	9836
SRP68	2334	-6940	-3114	7819	263	3725
SRP72	-8913	-8746	-4387	-4760	-7242	547
SRP9	-9348	-8500	-7551	-7310	-2896	6280
SRPRA	-3921	1934	2008	10115	-620	4589
SRPRB	-8573	-9412	-6590	1116	-4202	4769
SSR1	-9647	-1028	-3957	-3204	545	7120
SSR2	-7574	-9507	-9852	-2876	-4192	282
SSR3	-9011	-9452	-4909	-5567	-6547	9216
SSR4	-2536	-9049	-4003	1246	-3308	-1106
TRAM1	-9520	-6952	1123	-2005	-5284	9539
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Acetylcholine binding and downstream events

Acetylcholine binding and downstream events

metric	value
setSize	5
pMANOVA	0.0508
p.adjustMANOVA	0.0877
s.dist	1.04
s.crp_t0_adj	0.268
s.crp_eos_adj	0.285
s.crp_pod1_adj	0.644
s.avb_t0_adj	0.591
s.avb_eos_adj	-0.0782
s.avb_pod1_adj	0.408
p.crp_t0_adj	0.299
p.crp_eos_adj	0.27
p.crp_pod1_adj	0.0127
p.avb_t0_adj	0.022
p.avb_eos_adj	0.762
p.avb_pod1_adj	0.114

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d3	d4
CHRNB2	8686	10698
CHRNA2	8871	8322
CHRNE	4669	8653
CHRNA5	5059	2795
CHRNA7	4866	1840

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CHRNA2	7443	1993	8871	8322	1702	2727
CHRNA5	445	4780	5059	2795	-2606	8461
CHRNA7	-3372	-4040	4866	1840	-2296	8865
CHRNB2	10474	5728	8686	10698	-1549	-2336
CHRNE	-310	8420	4669	8653	4878	5740

---

---

Postsynaptic nicotinic acetylcholine receptors

Postsynaptic nicotinic acetylcholine receptors

metric	value
setSize	5
pMANOVA	0.0508
p.adjustMANOVA	0.0877
s.dist	1.04
s.crp_t0_adj	0.268
s.crp_eos_adj	0.285
s.crp_pod1_adj	0.644
s.avb_t0_adj	0.591
s.avb_eos_adj	-0.0782
s.avb_pod1_adj	0.408
p.crp_t0_adj	0.299
p.crp_eos_adj	0.27
p.crp_pod1_adj	0.0127
p.avb_t0_adj	0.022
p.avb_eos_adj	0.762
p.avb_pod1_adj	0.114

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d3	d4
CHRNB2	8686	10698
CHRNA2	8871	8322
CHRNE	4669	8653
CHRNA5	5059	2795
CHRNA7	4866	1840

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CHRNA2	7443	1993	8871	8322	1702	2727
CHRNA5	445	4780	5059	2795	-2606	8461
CHRNA7	-3372	-4040	4866	1840	-2296	8865
CHRNB2	10474	5728	8686	10698	-1549	-2336
CHRNE	-310	8420	4669	8653	4878	5740

---

---

RUNX1 regulates transcription of genes involved in BCR signaling

RUNX1 regulates transcription of genes involved in BCR signaling

metric	value
setSize	6
pMANOVA	0.00888
p.adjustMANOVA	0.0202
s.dist	1.04
s.crp_t0_adj	7.93e-05
s.crp_eos_adj	0.343
s.crp_pod1_adj	0.594
s.avb_t0_adj	-0.15
s.avb_eos_adj	-0.69
s.avb_pod1_adj	0.342
p.crp_t0_adj	1
p.crp_eos_adj	0.146
p.crp_pod1_adj	0.0118
p.avb_t0_adj	0.526
p.avb_eos_adj	0.00342
p.avb_pod1_adj	0.147

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d5	d3
BLK	-8019	7735
RUNX1	-5408	10159
PAX5	-5439	7193
ELF2	-6078	4056
CBFB	-5007	4917
ELF1	-8488	1368

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
BLK	4503	-1649	7735	-7618	-8019	-3475
CBFB	-7025	162	4917	-6769	-5007	9367
ELF1	-9183	824	1368	-4040	-8488	4679
ELF2	-6536	8048	4056	2150	-6078	1162
PAX5	9468	5937	7193	-86	-5439	1610
RUNX1	9489	10602	10159	8402	-5408	10639

---

---

Replacement of protamines by nucleosomes in the male pronucleus

Replacement of protamines by nucleosomes in the male pronucleus

metric	value
setSize	12
pMANOVA	0.000311
p.adjustMANOVA	0.00107
s.dist	1.04
s.crp_t0_adj	-0.282
s.crp_eos_adj	-0.613
s.crp_pod1_adj	0.251
s.avb_t0_adj	-0.286
s.avb_eos_adj	-0.629
s.avb_pod1_adj	0.3
p.crp_t0_adj	0.0913
p.crp_eos_adj	0.000237
p.crp_pod1_adj	0.133
p.avb_t0_adj	0.0866
p.avb_eos_adj	0.000163
p.avb_pod1_adj	0.0715

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d5	d2
H2BC21	-9222	-10053
H2BC11	-9213	-9885
H2BC12	-9044	-9707
H2BC4	-9241	-9409
H2BC9	-9332	-8938
H2BC5	-8941	-9201
H2BC17	-8844	-9191
H2BC15	-8762	-7716
H3-3A	-6952	-7308
METTL23	-308	-6196

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
H2BC11	-1531	-9885	2780	-5255	-9213	4417
H2BC12	4197	-9707	7248	-2347	-9044	1873
H2BC15	-9014	-7716	3551	-4117	-8762	5326
H2BC17	-1777	-9191	1441	218	-8844	6062
H2BC21	-5909	-10053	840	-4326	-9222	7353
H2BC4	585	-9409	1191	234	-9241	835
H2BC5	-5703	-9201	3020	-5854	-8941	-7957
H2BC9	-8218	-8938	3740	-6798	-9332	3121
H3-3A	-9371	-7308	-1646	-7693	-6952	9839
HIRA	1340	4577	2771	10559	8110	994
METTL23	-3182	-6196	-7125	-4045	-308	1267
SRPK1	4498	10332	9791	-3661	2648	9560

---

---

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

metric	value
setSize	5
pMANOVA	0.0663
p.adjustMANOVA	0.109
s.dist	1.04
s.crp_t0_adj	-0.412
s.crp_eos_adj	-0.678
s.crp_pod1_adj	-0.575
s.avb_t0_adj	0.233
s.avb_eos_adj	0.0378
s.avb_pod1_adj	-0.256
p.crp_t0_adj	0.111
p.crp_eos_adj	0.00861
p.crp_pod1_adj	0.026
p.avb_t0_adj	0.367
p.avb_eos_adj	0.884
p.avb_pod1_adj	0.322

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
ECHS1	-8779	-10322
HADHA	-7908	-7151
HADH	-4754	-8364
ACADS	-8296	-3173
HADHB	-4014	-2878

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
ACADS	-2919	-8296	-3173	2238	-1597	-6306
ECHS1	-2	-8779	-10322	4140	9679	-6442
HADH	-1616	-4754	-8364	8746	4759	-3558
HADHA	-8643	-7908	-7151	-301	-3238	-185
HADHB	-7891	-4014	-2878	-1355	-3377	5034

---

---

Activation of caspases through apoptosome-mediated cleavage

Activation of caspases through apoptosome-mediated cleavage

metric	value
setSize	6
pMANOVA	0.00657
p.adjustMANOVA	0.0157
s.dist	1.04
s.crp_t0_adj	-0.597
s.crp_eos_adj	-0.286
s.crp_pod1_adj	0.148
s.avb_t0_adj	-0.0998
s.avb_eos_adj	0.0274
s.avb_pod1_adj	0.781
p.crp_t0_adj	0.0113
p.crp_eos_adj	0.225
p.crp_pod1_adj	0.53
p.avb_t0_adj	0.672
p.avb_eos_adj	0.908
p.avb_pod1_adj	0.000927

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d6	d1
CASP3	10456	-8204
APAF1	8848	-7565
CASP7	7233	-9154
XIAP	9972	-3582
CYCS	5726	-5812
CASP9	9402	-2618

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
APAF1	-7565	9722	512	1301	9434	8848
CASP3	-8204	-6353	2355	5955	-350	10456
CASP7	-9154	-9023	-2999	-8460	-3742	7233
CASP9	-2618	-5401	1565	9129	6013	9402
CYCS	-5812	-7008	2342	-8485	-7167	5726
XIAP	-3582	2315	3550	-4265	2623	9972

---

---

Phosphorylation of Emi1

Phosphorylation of Emi1

metric	value
setSize	6
pMANOVA	0.00476
p.adjustMANOVA	0.0119
s.dist	1.03
s.crp_t0_adj	0.232
s.crp_eos_adj	-0.247
s.crp_pod1_adj	0.439
s.avb_t0_adj	0.734
s.avb_eos_adj	-0.0986
s.avb_pod1_adj	0.453
p.crp_t0_adj	0.326
p.crp_eos_adj	0.294
p.crp_pod1_adj	0.0628
p.avb_t0_adj	0.00185
p.avb_eos_adj	0.676
p.avb_pod1_adj	0.0546

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d4	d6
CDK1	9454	10765
CDC20	8605	10659
PLK1	10389	6653
CCNB1	2798	10032
FBXO5	6724	1330

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CCNB1	-5231	-7397	7289	2798	-4729	10032
CDC20	687	-5685	7798	8605	-5734	10659
CDK1	-3151	-6440	8788	9454	-2555	10765
FBXO5	6883	-980	-1961	6724	2979	1330
FZR1	8216	7443	-2182	9793	4870	-8462
PLK1	7911	-247	5923	10389	4033	6653

---

---

FASTK family proteins regulate processing and stability of mitochondrial RNAs

FASTK family proteins regulate processing and stability of mitochondrial RNAs

metric	value
setSize	19
pMANOVA	2.11e-08
p.adjustMANOVA	1.57e-07
s.dist	1.02
s.crp_t0_adj	-0.0945
s.crp_eos_adj	-0.723
s.crp_pod1_adj	-0.0367
s.avb_t0_adj	-0.14
s.avb_eos_adj	-0.691
s.avb_pod1_adj	-0.146
p.crp_t0_adj	0.476
p.crp_eos_adj	4.93e-08
p.crp_pod1_adj	0.782
p.avb_t0_adj	0.291
p.avb_eos_adj	1.84e-07
p.avb_pod1_adj	0.27

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d2	d5
MT-RNR2	-10132	-9027
MT-RNR1	-10133	-8717
MT-ND2	-9880	-8861
MT-ND1	-9805	-8925
MT-ND3	-9807	-7668
MT-CO2	-9228	-7902
MT-ATP6	-8566	-8107
MT-CYB	-7412	-8486
MT-CO3	-8734	-7109
MT-ND4	-7202	-8306
MT-ND4L	-8124	-7175
TBRG4	-7210	-7978
MT-ND5	-6455	-8545
MT-CO1	-6897	-7065
FASTKD5	-2801	-7785
MT-ATP8	-4968	-2170

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
FASTK	8506	-3629	-1413	5893	1861	-3281
FASTKD2	-5425	-6580	-10265	4146	7236	-3855
FASTKD5	-4547	-2801	163	-2141	-7785	-2575
MT-ATP6	339	-8566	3532	104	-8107	12
MT-ATP8	1714	-4968	3908	1307	-2170	1555
MT-CO1	1232	-6897	-4563	-4418	-7065	-7906
MT-CO2	-1701	-9228	-1410	-1379	-7902	-4171
MT-CO3	-3311	-8734	-2651	-3470	-7109	-170
MT-CYB	1722	-7412	1478	-2189	-8486	-3490
MT-ND1	-4232	-9805	-5013	-2663	-8925	-739
MT-ND2	-3916	-9880	-6082	-7654	-8861	-4189
MT-ND3	-4870	-9807	-4356	-4129	-7668	-1049
MT-ND4	-279	-7202	3150	-4211	-8306	-2644
MT-ND4L	3212	-8124	5915	3157	-7175	674
MT-ND5	-1648	-6455	3463	-5459	-8545	-2296
MT-ND6	4260	601	5885	-4793	-7070	210
MT-RNR1	-8059	-10133	-4946	-2980	-8717	8148
MT-RNR2	-7592	-10132	-3527	-958	-9027	9774
TBRG4	7983	-7210	3039	8560	-7978	-5613

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	99
pMANOVA	3.51e-46
p.adjustMANOVA	1.98e-44
s.dist	1.02
s.crp_t0_adj	-0.231
s.crp_eos_adj	-0.769
s.crp_pod1_adj	-0.583
s.avb_t0_adj	-0.137
s.avb_eos_adj	-0.033
s.avb_pod1_adj	-0.213
p.crp_t0_adj	7.38e-05
p.crp_eos_adj	4.63e-40
p.crp_pod1_adj	1.04e-23
p.avb_t0_adj	0.0183
p.avb_eos_adj	0.571
p.avb_pod1_adj	0.000242

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
RPS13	-9834	-9986
RPS4X	-9724	-10093
RPL29	-9652	-9844
RPL4	-9745	-9578
RPL7	-9819	-9495
RPS3A	-9728	-9449
RPL35A	-9810	-9364
RPL22L1	-9774	-9345
RPS7	-9828	-9245
RPL5	-9726	-9296
RPL26	-9387	-9522
RPL34	-9432	-9406
RPS20	-9658	-9149
RPL6	-9635	-8939
RPL18	-9242	-9308
RPL7A	-9533	-8984
RPL12	-9532	-8915
RPS3	-9159	-9204
RPL10	-9167	-9137
RPL15	-9523	-8791

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
ASNS	6976	8383	-1418	-2817	6514	2918
ATF2	-9476	-288	227	942	-4667	5956
ATF3	-3145	7932	8963	-10034	10495	4137
ATF4	-7176	-9644	-7553	-7333	-7568	-7327
CEBPB	6586	7206	7970	1327	-3532	7563
CEBPG	-7272	-7475	-5033	-5269	-201	-2888
DDIT3	3589	-7560	932	-8052	-5207	-5831
EIF2AK4	-9906	-9045	-7548	-4943	-3586	-5402
EIF2S1	-6582	-4155	1124	-6654	-5406	7600
EIF2S2	-5329	-7707	999	-3535	-999	8801
EIF2S3	-7740	-8442	-8388	-8157	-1854	5387
FAU	-307	-8617	-7795	3589	-499	-4729
GCN1	7081	5561	3488	10550	-3508	-6483
IMPACT	-9770	-6280	-6422	-3359	-1837	1926
RPL10	-3705	-9167	-9137	-260	1694	-5198
RPL10A	-1979	-9579	-8043	-283	682	-1296
RPL11	-3089	-9263	-8876	-654	588	-2520
RPL12	-2752	-9532	-8915	373	4403	2316
RPL13	5917	-7041	-5763	2104	6501	2464
RPL13A	1072	-9131	-8577	-487	1888	-4029
RPL14	-5556	-9615	-8205	-4360	1128	509
RPL15	-6557	-9523	-8791	-3699	-1586	-4994
RPL17	-3771	-9211	-8307	-1318	1770	54
RPL18	-835	-9242	-9308	-618	1086	-5236
RPL18A	-218	-9027	-8172	-1102	403	-5581
RPL19	-2231	-9236	-8248	-691	908	-2496
RPL21	-5820	-9627	-8521	-4771	1793	-1138
RPL22	-6366	-9248	-9002	-3603	3957	52
RPL22L1	-8058	-9774	-9345	-7761	-5643	581
RPL23	-7249	-9420	-7803	-2425	1304	-1573
RPL23A	-6304	-8773	-8640	-7182	555	-3392
RPL24	-6905	-9799	-7959	-4361	-593	782
RPL26	-3994	-9387	-9522	-222	379	-4607
RPL26L1	-3775	-8443	1506	-1254	-4671	3840
RPL27	-2120	-9517	-7209	-2440	-72	-1560
RPL27A	-1124	-8915	-7166	2709	4684	1491
RPL28	4558	-7064	-6507	2471	-394	-2856
RPL29	-4076	-9652	-9844	-3937	-855	-7173
RPL3	-3185	-8502	-8670	-1991	1351	-4095
RPL30	-2372	-9198	-8610	-510	-384	-4911
RPL31	-2271	-9112	-8328	146	3518	-3516
RPL32	-1227	-9273	-7765	1693	-547	-3264
RPL34	-4086	-9432	-9406	-842	1705	-5248
RPL35	5207	-8962	-5290	4185	3131	-2729
RPL35A	-4602	-9810	-9364	-2137	535	-2149
RPL36	3025	-7125	-5804	363	2651	-3238
RPL36A	-4529	-9682	-8580	-4795	1682	-3387
RPL36AL	3974	-6334	314	3561	-5086	3574
RPL37	2174	-7802	-6596	4357	-752	-4024
RPL37A	-797	-9181	-6452	3270	1168	-2045
RPL38	-2767	-8226	-7482	546	645	-5149
RPL39	-7773	-9081	-8028	-4974	-1335	-5117
RPL39L	-2179	-8103	-9774	9197	4471	-6715
RPL4	-7404	-9745	-9578	-4759	468	-2919
RPL41	-2134	-9061	-6688	4053	-151	-221
RPL5	-7820	-9726	-9296	-5906	1947	-1347
RPL6	-6768	-9635	-8939	-5292	674	-1097
RPL7	-7395	-9819	-9495	-3808	3689	-2235
RPL7A	-4924	-9533	-8984	-4385	-1202	-2703
RPL8	-2894	-9466	-8839	-2437	-1803	-7318
RPL9	4794	-203	453	7430	4384	1761
RPLP0	-2819	-8953	-5802	-1710	-756	-2991
RPLP1	3361	-6765	-4215	2475	4472	-541
RPLP2	3116	-6920	-6938	-538	2802	-3189
RPS10	-1940	-8920	-8524	-376	2180	-3511
RPS11	-2049	-8989	-8781	-1743	-837	-6413
RPS12	2670	-7905	-7479	-1734	4054	-552
RPS13	-5717	-9834	-9986	-4338	1796	-5727
RPS14	-1829	-7774	-8249	-5742	-2138	-6905
RPS15	-96	-8450	-7544	972	1735	-4373
RPS15A	-4150	-9501	-7169	-629	-415	-1163
RPS16	4719	-6172	-6969	-1629	284	-6786
RPS17	4656	-8299	-4903	1086	4235	-158
RPS18	-421	-7994	-6273	2604	1504	-1903
RPS19	1476	-8791	-6314	3211	859	-1542
RPS2	-1660	-7525	-7597	1222	2227	-6500
RPS20	-4082	-9658	-9149	-3237	2009	-2788
RPS21	952	-6537	-6291	1717	2144	-2270
RPS23	-1234	-9376	-7077	502	1540	-2873
RPS24	-6272	-9539	-8118	177	1637	-976
RPS25	-5113	-9637	-8163	-3423	1743	285
RPS26	10194	7452	6217	6219	5245	3258
RPS27	-2121	-9329	-5996	198	-545	-1744
RPS27A	-4122	-8742	-8642	-4052	3532	-1954
RPS27L	-917	-8401	-7829	-5357	-1687	4867
RPS28	1971	-6410	-7057	1324	245	-4879
RPS29	1441	-6901	-2879	443	-225	-964
RPS3	-1921	-9159	-9204	-1766	-38	-3224
RPS3A	-6349	-9728	-9449	-3926	3247	-2334
RPS4X	-9204	-9724	-10093	-5889	-3337	-6275
RPS4Y1	-5531	-6839	-9414	3682	-3724	-9581
RPS5	4857	-8051	-5749	-2584	398	-4109
RPS6	-4548	-9462	-7590	-2074	1712	2638
RPS7	-6829	-9828	-9245	-2078	390	-292
RPS8	-6025	-9563	-7489	-7057	815	-937
RPS9	-3610	-9188	-4802	3710	-323	4130
RPSA	-2829	-9209	-6565	-528	-3825	804
TRIB3	768	-2854	4504	5072	1430	2094
UBA52	-2556	-9138	-8674	-1579	-3439	-4257

---

---

Post-transcriptional silencing by small RNAs

Post-transcriptional silencing by small RNAs

metric	value
setSize	7
pMANOVA	0.00157
p.adjustMANOVA	0.00448
s.dist	1.02
s.crp_t0_adj	-0.211
s.crp_eos_adj	0.714
s.crp_pod1_adj	0.323
s.avb_t0_adj	0.245
s.avb_eos_adj	0.377
s.avb_pod1_adj	0.419
p.crp_t0_adj	0.333
p.crp_eos_adj	0.00106
p.crp_pod1_adj	0.139
p.avb_t0_adj	0.261
p.avb_eos_adj	0.0843
p.avb_pod1_adj	0.0546

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d2	d6
TNRC6C	10742	8684
AGO4	8435	8271
TNRC6B	9767	4751
AGO3	4353	6096
AGO2	6659	2813
TNRC6A	5766	3145

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
AGO1	-7318	9530	2874	3335	11262	-97
AGO2	-651	6659	1404	6750	-4591	2813
AGO3	-5669	4353	2374	-2041	4027	6096
AGO4	-10178	8435	2792	-6955	2738	8271
TNRC6A	1269	5766	1477	9194	7012	3145
TNRC6B	-1395	9767	5112	1163	3912	4751
TNRC6C	9238	10742	5379	8316	9294	8684

---

---

CD22 mediated BCR regulation

CD22 mediated BCR regulation

metric	value
setSize	57
pMANOVA	1.32e-36
p.adjustMANOVA	4.97e-35
s.dist	1.01
s.crp_t0_adj	0.155
s.crp_eos_adj	-0.551
s.crp_pod1_adj	0.232
s.avb_t0_adj	0.41
s.avb_eos_adj	-0.52
s.avb_pod1_adj	0.45
p.crp_t0_adj	0.0431
p.crp_eos_adj	5.94e-13
p.crp_pod1_adj	0.00244
p.avb_t0_adj	8.39e-08
p.avb_eos_adj	1.06e-11
p.avb_pod1_adj	4.24e-09

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d2	d5
IGLV1-44	-9860	-8740
IGKV1-33	-10098	-8134
IGLV2-23	-9567	-8069
IGLV1-51	-9956	-7584
IGHV3-13	-8520	-8402
IGKC	-9089	-7541
IGKV4-1	-10039	-6801
IGKV1-16	-9218	-7396
IGHV2-5	-7185	-8946
IGLC1	-8437	-7572
IGKV2-30	-7419	-8346
IGHV3-48	-8567	-7024
IGHV3-23	-7395	-7388
IGHV3-7	-6819	-7548
IGLV2-11	-9127	-5622
IGLV7-43	-9279	-5018
IGLC2	-8663	-5322
IGHV1-2	-7483	-6048
IGKV2-28	-9761	-4554
IGLV3-27	-9480	-4629

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CD22	8459	-1089	6346	4499	-4746	814
CD79A	6026	-3284	4257	189	-7230	1125
CD79B	8191	-4684	1982	3265	3849	5453
IGHD	2752	-5883	-2561	-4742	-6556	-6185
IGHM	10080	-26	7824	6291	-7514	3542
IGHV1-2	2070	-7483	-937	9896	-6048	9103
IGHV1-46	-363	-6964	4528	8867	-4662	5742
IGHV1-69	6180	849	5197	5297	-5853	7334
IGHV2-5	6695	-7185	4466	4378	-8946	6443
IGHV2-70	6210	-1434	4195	7670	-3832	8358
IGHV3-11	-2065	-7827	1234	5488	-5121	234
IGHV3-13	-9016	-8520	3728	319	-8402	7126
IGHV3-23	-3188	-7395	-1580	7988	-7388	7774
IGHV3-30	1238	295	826	6697	-1350	620
IGHV3-33	8144	-5592	7514	6618	-6673	9371
IGHV3-48	-7604	-8567	-787	336	-7024	2568
IGHV3-53	8266	-732	7242	-6078	-6838	-356
IGHV3-7	871	-6819	6924	2624	-7548	4854
IGHV4-34	10450	-4671	7706	10730	-6861	9633
IGHV4-39	8578	-4489	5199	10692	-102	10282
IGHV4-59	7846	-5850	6639	10585	-5810	9416
IGKC	3109	-9089	2037	6705	-7541	7614
IGKV1-12	-248	-6962	2457	-7027	-5848	-501
IGKV1-16	-8414	-9218	-5200	-4108	-7396	5952
IGKV1-17	9849	-3387	4444	10565	-5361	8810
IGKV1-33	-230	-10098	-4163	5763	-8134	486
IGKV1-5	4235	-6635	4041	9693	-5929	8711
IGKV1D-39	8768	-7554	4003	9217	-5377	9102
IGKV2-28	1586	-9761	-4139	8892	-4554	7493
IGKV2-29	7735	10825	5094	-10045	-4250	-4093
IGKV2-30	272	-7419	-1608	-3305	-8346	-7487
IGKV2D-28	-796	-405	8038	-2549	-2957	4052
IGKV3-11	9382	-1738	8125	-865	-7343	2007
IGKV3-15	4226	-3604	6665	10222	-6091	10067
IGKV3-20	6774	-9321	1136	9483	-4543	9785
IGKV3D-20	1741	-9092	233	7046	-817	5748
IGKV4-1	52	-10039	332	10314	-6801	10290
IGLC1	-6983	-8437	-5794	-4675	-7572	-970
IGLC2	4091	-8663	-556	8711	-5322	7791
IGLC3	-1591	-6796	4245	-1381	-6106	1467
IGLV1-40	1199	-6430	3783	6032	-5135	5392
IGLV1-44	-3234	-9860	-3594	3278	-8740	-719
IGLV1-47	5010	-2886	-4330	10175	2011	8698
IGLV1-51	-8540	-9956	-3032	-2737	-7584	5225
IGLV2-11	-9434	-9127	-5916	9229	-5622	1452
IGLV2-14	4387	-6036	1725	5772	1473	9294
IGLV2-23	-9751	-9567	-6004	-4393	-8069	629
IGLV2-8	-596	-4185	-150	1186	-4051	4245
IGLV3-1	9763	3901	6729	10427	5371	7751
IGLV3-19	6777	-5435	5707	8988	-6039	3174
IGLV3-21	-4959	-7601	-3956	9589	2538	9860
IGLV3-25	-223	-6821	6545	9984	-1186	10367
IGLV3-27	-4552	-9480	-3313	10193	-4629	7558
IGLV6-57	-5834	-9478	1634	1986	-1633	7354
IGLV7-43	-1937	-9279	-2141	8174	-5018	6811
LYN	-7116	7500	9091	-1698	6351	10501
PTPN6	4998	1802	7484	8765	2153	4430

---

---

G2 Phase

G2 Phase

metric	value
setSize	5
pMANOVA	0.0484
p.adjustMANOVA	0.0842
s.dist	1.01
s.crp_t0_adj	-0.065
s.crp_eos_adj	-0.503
s.crp_pod1_adj	0.451
s.avb_t0_adj	0.113
s.avb_eos_adj	-0.615
s.avb_pod1_adj	0.403
p.crp_t0_adj	0.801
p.crp_eos_adj	0.0514
p.crp_pod1_adj	0.081
p.avb_t0_adj	0.66
p.avb_eos_adj	0.0172
p.avb_pod1_adj	0.119

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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	d5	d2
CCNA1	-9472	-6350
E2F1	-6102	-9835
CCNA2	-3778	-5008
E2F3	-9381	-1508

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
CCNA1	1391	-6350	9919	-8703	-9472	10662
CCNA2	-263	-5008	9861	6535	-3778	9978
CDK2	-264	-1836	2712	9085	618	-6371
E2F1	4729	-9835	-1708	5006	-6102	4485
E2F3	-8418	-1508	1229	-4732	-9381	4415

---

---

Mitochondrial translation initiation

Mitochondrial translation initiation

metric	value
setSize	90
pMANOVA	2.27e-46
p.adjustMANOVA	1.36e-44
s.dist	1
s.crp_t0_adj	-0.112
s.crp_eos_adj	-0.803
s.crp_pod1_adj	-0.566
s.avb_t0_adj	0.09
s.avb_eos_adj	-0.101
s.avb_pod1_adj	-0.0876
p.crp_t0_adj	0.0658
p.crp_eos_adj	9.09e-40
p.crp_pod1_adj	1.53e-20
p.avb_t0_adj	0.14
p.avb_eos_adj	0.0964
p.avb_pod1_adj	0.151

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	d2	d3
MRPS21	-9960	-10070
MRPL32	-9534	-10452
MRPL45	-9354	-10303
MTIF2	-9414	-9753
MRPL37	-10052	-9109
DAP3	-9663	-9320
MRPL34	-9449	-9410
MRPL15	-10076	-8792
MRPS7	-9673	-9018
MRPS18B	-9136	-9508
MRPL57	-9531	-8929
MRPL20	-9239	-8959
MRPS27	-9156	-8842
OXA1L	-8551	-9294
MRPL40	-9574	-8088
MRPL48	-9297	-8060
MRPS14	-7692	-9701
MRPL55	-7747	-9409
MRPL46	-9258	-7864
MRPL27	-8639	-8425

Click HERE to show all gene set members

All member genes

	crp_t0_adj	crp_eos_adj	crp_pod1_adj	avb_t0_adj	avb_eos_adj	avb_pod1_adj
AURKAIP1	38	-6862	-6345	3935	-472	-2626
CHCHD1	-1363	-9197	-4558	5414	1015	5963
DAP3	-8357	-9663	-9320	-2701	710	1177
ERAL1	4164	-7639	-7579	5055	1443	-8443
GADD45GIP1	4102	-9067	-2295	1381	-3389	-2611
MRPL1	533	-6587	-5909	-5022	-3249	9204
MRPL10	-6572	-6914	-9967	5972	-1571	-2208
MRPL11	756	-9363	-7688	2603	-1222	-3564
MRPL12	-2004	-9344	-5499	2220	1512	-5785
MRPL13	-3449	-7447	-4473	-2542	3112	1843
MRPL14	5374	-8178	-8828	1595	1582	-6889
MRPL15	-1161	-10076	-8792	-643	-8307	-3728
MRPL16	-1139	-9091	-7620	3607	536	-1388
MRPL17	1913	-9551	-7403	1028	-721	153
MRPL18	7093	-8407	2170	6065	4010	6446
MRPL19	-2801	-6451	-4138	-6761	-1831	4189
MRPL2	6841	-5278	-9404	8905	9693	-7217
MRPL20	-2595	-9239	-8959	5162	-2234	-5406
MRPL21	5950	-7779	-3914	1605	-3811	-5412
MRPL22	-5789	-7108	-5704	-3630	543	7445
MRPL23	-154	-8040	-974	8906	483	2286
MRPL24	3957	-8956	-5408	9686	-4456	-3291
MRPL27	-1090	-8639	-8425	2035	3830	-4948
MRPL28	1559	-5939	445	7823	813	3919
MRPL3	-9501	-10015	-7112	-8212	-9556	-204
MRPL30	-3414	-5866	-6689	-3582	7213	3799
MRPL32	-9310	-9534	-10452	-7219	-4312	-8848
MRPL33	-6214	-7045	-3820	2225	5025	8882
MRPL34	-9262	-9449	-9410	-5717	-1728	-7348
MRPL35	3177	-5306	-7006	1833	4328	5014
MRPL36	2612	-8945	-1858	6848	-5250	1336
MRPL37	-8485	-10052	-9109	1383	-250	-7079
MRPL38	5984	-6723	-3892	8078	91	-7995
MRPL39	3490	-5678	-9021	-1244	1028	-8142
MRPL4	6289	-8193	-6336	6684	-4243	-7744
MRPL40	-3285	-9574	-8088	-4523	-4809	-5027
MRPL41	9339	-4860	-6954	8008	3915	-8930
MRPL42	-7007	-3759	-6306	-6684	142	2102
MRPL43	4739	-7299	-7972	7774	4554	-4135
MRPL44	-3393	-9129	-5477	2551	-1937	4378
MRPL45	-5707	-9354	-10303	-3849	4507	-988
MRPL46	3089	-9258	-7864	8199	2653	-1874
MRPL47	-3679	-8154	-3287	2382	-2744	7846
MRPL48	-3799	-9297	-8060	-2382	-4386	-6208
MRPL49	-1523	-8262	-6705	9708	-2712	-81
MRPL50	2415	-1459	-5517	98	-673	6155
MRPL51	-204	-9760	-2970	7515	-465	5519
MRPL52	8978	-9006	-567	7406	1580	3814
MRPL53	477	-8769	-2818	4932	-311	3363
MRPL54	523	-8921	-7424	2341	6125	-4949
MRPL55	2572	-7747	-9409	5398	-1919	-7722
MRPL57	672	-9531	-8929	4433	1333	-6013
MRPL58	-2407	-8672	-4377	832	-290	-10
MRPL9	-632	-8505	-7480	5486	-13	-4881
MRPS10	-2997	-5853	-4083	-3239	-563	7810
MRPS11	5926	-8785	3311	6646	1417	1030
MRPS14	-6534	-7692	-9701	2130	1083	-2605
MRPS15	-4171	-9765	-3766	142	-3600	-1530
MRPS16	819	-9947	-6697	3734	-3767	4746
MRPS17	-1639	-8913	-7136	3976	-6500	-426
MRPS18A	2969	-8113	-5917	1234	-1049	491
MRPS18B	388	-9136	-9508	-3465	-1476	-1989
MRPS18C	-6267	-9118	-5848	-2700	5544	8160
MRPS2	6429	-8064	-8900	4087	-6114	-8829
MRPS21	-1266	-9960	-10070	374	-3935	-7732
MRPS22	-8010	-9733	-7054	2653	-4419	2868
MRPS23	-2769	-8298	-3317	1068	2708	6399
MRPS24	-746	-8138	-6694	2790	2085	-3828
MRPS25	-6410	-6105	-10782	-6759	8002	-10088
MRPS26	4509	-8431	-6280	2879	-1791	-5509
MRPS27	-5281	-9156	-8842	-4650	-4256	-5137
MRPS28	-735	-9901	-5293	-1206	626	-628
MRPS30	-7992	-6978	-8581	-507	-6237	-2776
MRPS31	5260	-5343	363	-5413	1559	9194
MRPS33	-3475	-6704	-6231	3296	8070	6687
MRPS34	2175	-7507	-5545	5093	356	-5187
MRPS35	-8740	-8697	-6061	-6613	-4389	5676
MRPS36	-4238	-6490	-2154	-6469	-337	7328
MRPS5	7725	-8671	-2548	157	-4263	-118
MRPS6	3646	3380	-7877	9104	11310	2972
MRPS7	1595	-9673	-9018	801	-1672	-4186
MRPS9	-575	-7005	-8421	2783	10167	5301
MT-RNR1	-8059	-10133	-4946	-2980	-8717	8148
MT-RNR2	-7592	-10132	-3527	-958	-9027	9774
MTFMT	-7117	-7825	-9228	2893	-138	2291
MTIF2	-7096	-9414	-9753	-4451	-345	1031
MTIF3	-4414	-8646	-3172	-6297	2436	5030
OXA1L	-6360	-8551	-9294	-5956	1906	-5964
PTCD3	-9065	-8233	-7808	-7957	-2916	-7594
RPS12	2670	-7905	-7479	-1734	4054	-552

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report