date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
crp_pod1_adj avb_pod1_adj
5_8S_rRNA 0.1666742 1.6789113
A1BG -1.0533748 -0.4773423
A1BG-AS1 -0.2260162 0.3881952
A1CF 1.1773907 -0.3059749
A2M 1.7931937 0.6340902
A2M-AS1 0.7455551 -1.0223656

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 21253
duplicated_genes_present 0
num_profile_genes_in_sets 8700
num_profile_genes_not_in_sets 12553
profile_pearson_correl 0.55004
profile_spearman_correl 0.51465

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1198
num_genesets_included 1527

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 564

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.crp_pod1_adj s.avb_pod1_adj p.crp_pod1_adj p.avb_pod1_adj
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 1.64e-03 8.75e-03 1.020 0.814 0.6100 5.54e-04 9.64e-03
Response to metal ions 6 2.02e-03 1.03e-02 1.010 0.774 0.6560 1.03e-03 5.36e-03
G2/M DNA replication checkpoint 5 9.83e-03 3.72e-02 0.966 0.692 0.6740 7.40e-03 9.00e-03
Fructose metabolism 7 2.81e-03 1.35e-02 0.912 -0.581 -0.7030 7.78e-03 1.27e-03
CD163 mediating an anti-inflammatory response 8 1.62e-06 2.08e-05 0.875 0.873 -0.0579 1.91e-05 7.77e-01
Butyrophilin (BTN) family interactions 10 7.71e-04 4.50e-03 0.849 -0.575 -0.6250 1.64e-03 6.21e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 4.57e-03 1.99e-02 0.843 0.456 0.7080 3.65e-02 1.17e-03
Fructose catabolism 5 2.86e-02 8.21e-02 0.826 -0.486 -0.6680 5.97e-02 9.65e-03
Regulation of IFNA/IFNB signaling 12 2.03e-04 1.45e-03 0.810 0.441 0.6790 8.20e-03 4.63e-05
Type I hemidesmosome assembly 8 5.83e-03 2.36e-02 0.806 0.566 0.5740 5.60e-03 4.92e-03
Activation of caspases through apoptosome-mediated cleavage 6 1.84e-03 9.58e-03 0.794 0.144 0.7810 5.42e-01 9.26e-04
Inhibition of Signaling by Overexpressed EGFR 5 4.08e-04 2.59e-03 0.780 0.753 -0.2020 3.54e-03 4.33e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 4.08e-04 2.59e-03 0.780 0.753 -0.2020 3.54e-03 4.33e-01
Establishment of Sister Chromatid Cohesion 11 3.92e-04 2.54e-03 0.770 0.344 0.6890 4.84e-02 7.49e-05
Maturation of protein 3a 9683673 9 4.46e-03 1.96e-02 0.762 0.454 0.6120 1.84e-02 1.46e-03
Maturation of protein 3a 9694719 9 4.46e-03 1.96e-02 0.762 0.454 0.6120 1.84e-02 1.46e-03
ARMS-mediated activation 6 1.65e-02 5.40e-02 0.761 0.351 0.6760 1.36e-01 4.16e-03
Acetylcholine binding and downstream events 5 4.36e-02 1.12e-01 0.759 0.640 0.4080 1.32e-02 1.14e-01
Postsynaptic nicotinic acetylcholine receptors 5 4.36e-02 1.12e-01 0.759 0.640 0.4080 1.32e-02 1.14e-01
Neurotransmitter clearance 6 5.46e-03 2.25e-02 0.755 -0.192 -0.7300 4.16e-01 1.96e-03
Protein repair 6 2.26e-02 6.83e-02 0.751 0.383 0.6460 1.05e-01 6.10e-03
Formation of xylulose-5-phosphate 5 1.56e-02 5.21e-02 0.750 -0.720 -0.2090 5.28e-03 4.18e-01
Synthesis of diphthamide-EEF2 8 7.19e-03 2.83e-02 0.748 -0.637 -0.3930 1.81e-03 5.41e-02
NFE2L2 regulates pentose phosphate pathway genes 8 1.97e-03 1.02e-02 0.734 0.701 0.2180 5.94e-04 2.85e-01
Formation of a pool of free 40S subunits 100 4.02e-32 1.29e-29 0.733 -0.686 -0.2580 1.71e-32 8.39e-06
Peptide chain elongation 88 4.71e-28 6.46e-26 0.732 -0.683 -0.2630 1.39e-28 2.04e-05
Interleukin-21 signaling 9 2.95e-03 1.39e-02 0.731 0.321 0.6570 9.58e-02 6.46e-04
Mitotic Telophase/Cytokinesis 13 1.04e-03 5.84e-03 0.721 0.448 0.5650 5.16e-03 4.22e-04
Eukaryotic Translation Elongation 93 1.14e-28 1.82e-26 0.718 -0.671 -0.2540 3.95e-29 2.31e-05
Selenocysteine synthesis 92 5.14e-28 6.58e-26 0.711 -0.666 -0.2480 2.01e-28 4.03e-05
SARS-CoV-1 modulates host translation machinery 36 5.45e-11 1.29e-09 0.708 -0.656 -0.2660 9.12e-12 5.74e-03
Viral mRNA Translation 88 2.32e-26 2.12e-24 0.697 -0.658 -0.2320 1.31e-26 1.68e-04
Eukaryotic Translation Termination 92 2.95e-27 3.15e-25 0.694 -0.655 -0.2320 1.70e-27 1.21e-04
EGFR interacts with phospholipase C-gamma 6 4.51e-04 2.84e-03 0.692 0.655 -0.2240 5.49e-03 3.42e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 8.84e-02 1.87e-01 0.687 0.418 0.5460 1.06e-01 3.45e-02
RUNX3 regulates CDKN1A transcription 7 3.02e-02 8.61e-02 0.685 -0.383 -0.5680 7.95e-02 9.30e-03
Platelet sensitization by LDL 16 5.21e-04 3.18e-03 0.685 0.436 0.5270 2.50e-03 2.59e-04
Interleukin-6 signaling 10 4.74e-03 2.04e-02 0.683 0.332 0.5970 6.90e-02 1.08e-03
RUNX1 regulates transcription of genes involved in BCR signaling 6 4.28e-02 1.11e-01 0.682 0.590 0.3420 1.23e-02 1.47e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 6.33e-02 1.47e-01 0.679 0.506 0.4530 3.17e-02 5.48e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.98e-26 2.61e-24 0.679 -0.637 -0.2350 1.16e-26 8.33e-05
L13a-mediated translational silencing of Ceruloplasmin expression 110 1.93e-31 4.12e-29 0.679 -0.642 -0.2190 2.14e-31 7.19e-05
Formation of the ternary complex, and subsequently, the 43S complex 51 4.41e-15 1.77e-13 0.679 -0.644 -0.2150 1.77e-15 7.89e-03
Scavenging by Class F Receptors 5 1.05e-01 2.13e-01 0.674 0.487 0.4660 5.94e-02 7.11e-02
Ethanol oxidation 6 5.20e-02 1.27e-01 0.672 -0.568 -0.3580 1.60e-02 1.29e-01
MET activates PI3K/AKT signaling 5 1.10e-01 2.17e-01 0.668 0.486 0.4580 5.99e-02 7.62e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 4.57e-02 1.16e-01 0.667 0.459 0.4830 3.53e-02 2.68e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.45e-30 2.54e-28 0.666 -0.630 -0.2140 1.55e-30 9.50e-05
Cap-dependent Translation Initiation 118 7.60e-32 1.83e-29 0.665 -0.626 -0.2220 5.65e-32 2.98e-05
Eukaryotic Translation Initiation 118 7.60e-32 1.83e-29 0.665 -0.626 -0.2220 5.65e-32 2.98e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.crp_pod1_adj s.avb_pod1_adj p.crp_pod1_adj p.avb_pod1_adj
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 1.64e-03 8.75e-03 1.02000 0.814000 6.10e-01 5.54e-04 9.64e-03
Response to metal ions 6 2.02e-03 1.03e-02 1.01000 0.774000 6.56e-01 1.03e-03 5.36e-03
G2/M DNA replication checkpoint 5 9.83e-03 3.72e-02 0.96600 0.692000 6.74e-01 7.40e-03 9.00e-03
Fructose metabolism 7 2.81e-03 1.35e-02 0.91200 -0.581000 -7.03e-01 7.78e-03 1.27e-03
CD163 mediating an anti-inflammatory response 8 1.62e-06 2.08e-05 0.87500 0.873000 -5.79e-02 1.91e-05 7.77e-01
Butyrophilin (BTN) family interactions 10 7.71e-04 4.50e-03 0.84900 -0.575000 -6.25e-01 1.64e-03 6.21e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 4.57e-03 1.99e-02 0.84300 0.456000 7.08e-01 3.65e-02 1.17e-03
Fructose catabolism 5 2.86e-02 8.21e-02 0.82600 -0.486000 -6.68e-01 5.97e-02 9.65e-03
Regulation of IFNA/IFNB signaling 12 2.03e-04 1.45e-03 0.81000 0.441000 6.79e-01 8.20e-03 4.63e-05
Type I hemidesmosome assembly 8 5.83e-03 2.36e-02 0.80600 0.566000 5.74e-01 5.60e-03 4.92e-03
Activation of caspases through apoptosome-mediated cleavage 6 1.84e-03 9.58e-03 0.79400 0.144000 7.81e-01 5.42e-01 9.26e-04
Inhibition of Signaling by Overexpressed EGFR 5 4.08e-04 2.59e-03 0.78000 0.753000 -2.02e-01 3.54e-03 4.33e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 4.08e-04 2.59e-03 0.78000 0.753000 -2.02e-01 3.54e-03 4.33e-01
Establishment of Sister Chromatid Cohesion 11 3.92e-04 2.54e-03 0.77000 0.344000 6.89e-01 4.84e-02 7.49e-05
Maturation of protein 3a 9683673 9 4.46e-03 1.96e-02 0.76200 0.454000 6.12e-01 1.84e-02 1.46e-03
Maturation of protein 3a 9694719 9 4.46e-03 1.96e-02 0.76200 0.454000 6.12e-01 1.84e-02 1.46e-03
ARMS-mediated activation 6 1.65e-02 5.40e-02 0.76100 0.351000 6.76e-01 1.36e-01 4.16e-03
Acetylcholine binding and downstream events 5 4.36e-02 1.12e-01 0.75900 0.640000 4.08e-01 1.32e-02 1.14e-01
Postsynaptic nicotinic acetylcholine receptors 5 4.36e-02 1.12e-01 0.75900 0.640000 4.08e-01 1.32e-02 1.14e-01
Neurotransmitter clearance 6 5.46e-03 2.25e-02 0.75500 -0.192000 -7.30e-01 4.16e-01 1.96e-03
Protein repair 6 2.26e-02 6.83e-02 0.75100 0.383000 6.46e-01 1.05e-01 6.10e-03
Formation of xylulose-5-phosphate 5 1.56e-02 5.21e-02 0.75000 -0.720000 -2.09e-01 5.28e-03 4.18e-01
Synthesis of diphthamide-EEF2 8 7.19e-03 2.83e-02 0.74800 -0.637000 -3.93e-01 1.81e-03 5.41e-02
NFE2L2 regulates pentose phosphate pathway genes 8 1.97e-03 1.02e-02 0.73400 0.701000 2.18e-01 5.94e-04 2.85e-01
Formation of a pool of free 40S subunits 100 4.02e-32 1.29e-29 0.73300 -0.686000 -2.58e-01 1.71e-32 8.39e-06
Peptide chain elongation 88 4.71e-28 6.46e-26 0.73200 -0.683000 -2.63e-01 1.39e-28 2.04e-05
Interleukin-21 signaling 9 2.95e-03 1.39e-02 0.73100 0.321000 6.57e-01 9.58e-02 6.46e-04
Mitotic Telophase/Cytokinesis 13 1.04e-03 5.84e-03 0.72100 0.448000 5.65e-01 5.16e-03 4.22e-04
Eukaryotic Translation Elongation 93 1.14e-28 1.82e-26 0.71800 -0.671000 -2.54e-01 3.95e-29 2.31e-05
Selenocysteine synthesis 92 5.14e-28 6.58e-26 0.71100 -0.666000 -2.48e-01 2.01e-28 4.03e-05
SARS-CoV-1 modulates host translation machinery 36 5.45e-11 1.29e-09 0.70800 -0.656000 -2.66e-01 9.12e-12 5.74e-03
Viral mRNA Translation 88 2.32e-26 2.12e-24 0.69700 -0.658000 -2.32e-01 1.31e-26 1.68e-04
Eukaryotic Translation Termination 92 2.95e-27 3.15e-25 0.69400 -0.655000 -2.32e-01 1.70e-27 1.21e-04
EGFR interacts with phospholipase C-gamma 6 4.51e-04 2.84e-03 0.69200 0.655000 -2.24e-01 5.49e-03 3.42e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 8.84e-02 1.87e-01 0.68700 0.418000 5.46e-01 1.06e-01 3.45e-02
RUNX3 regulates CDKN1A transcription 7 3.02e-02 8.61e-02 0.68500 -0.383000 -5.68e-01 7.95e-02 9.30e-03
Platelet sensitization by LDL 16 5.21e-04 3.18e-03 0.68500 0.436000 5.27e-01 2.50e-03 2.59e-04
Interleukin-6 signaling 10 4.74e-03 2.04e-02 0.68300 0.332000 5.97e-01 6.90e-02 1.08e-03
RUNX1 regulates transcription of genes involved in BCR signaling 6 4.28e-02 1.11e-01 0.68200 0.590000 3.42e-01 1.23e-02 1.47e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 6.33e-02 1.47e-01 0.67900 0.506000 4.53e-01 3.17e-02 5.48e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.98e-26 2.61e-24 0.67900 -0.637000 -2.35e-01 1.16e-26 8.33e-05
L13a-mediated translational silencing of Ceruloplasmin expression 110 1.93e-31 4.12e-29 0.67900 -0.642000 -2.19e-01 2.14e-31 7.19e-05
Formation of the ternary complex, and subsequently, the 43S complex 51 4.41e-15 1.77e-13 0.67900 -0.644000 -2.15e-01 1.77e-15 7.89e-03
Scavenging by Class F Receptors 5 1.05e-01 2.13e-01 0.67400 0.487000 4.66e-01 5.94e-02 7.11e-02
Ethanol oxidation 6 5.20e-02 1.27e-01 0.67200 -0.568000 -3.58e-01 1.60e-02 1.29e-01
MET activates PI3K/AKT signaling 5 1.10e-01 2.17e-01 0.66800 0.486000 4.58e-01 5.99e-02 7.62e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 4.57e-02 1.16e-01 0.66700 0.459000 4.83e-01 3.53e-02 2.68e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.45e-30 2.54e-28 0.66600 -0.630000 -2.14e-01 1.55e-30 9.50e-05
Cap-dependent Translation Initiation 118 7.60e-32 1.83e-29 0.66500 -0.626000 -2.22e-01 5.65e-32 2.98e-05
Eukaryotic Translation Initiation 118 7.60e-32 1.83e-29 0.66500 -0.626000 -2.22e-01 5.65e-32 2.98e-05
Phenylalanine metabolism 5 1.05e-01 2.12e-01 0.66400 -0.526000 -4.05e-01 4.18e-02 1.17e-01
Cohesin Loading onto Chromatin 10 1.09e-02 4.01e-02 0.65900 0.390000 5.32e-01 3.27e-02 3.59e-03
N-Glycan antennae elongation 12 5.71e-03 2.32e-02 0.65900 0.473000 4.60e-01 4.57e-03 5.84e-03
ROBO receptors bind AKAP5 7 2.30e-02 6.91e-02 0.65300 0.264000 5.97e-01 2.26e-01 6.19e-03
Erythrocytes take up oxygen and release carbon dioxide 7 1.55e-02 5.19e-02 0.64300 0.614000 1.93e-01 4.92e-03 3.76e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 4.04e-02 1.06e-01 0.64200 -0.152000 -6.24e-01 5.56e-01 1.57e-02
SMAC (DIABLO) binds to IAPs 7 2.94e-03 1.39e-02 0.64100 0.004120 6.41e-01 9.85e-01 3.31e-03
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 2.94e-03 1.39e-02 0.64100 0.004120 6.41e-01 9.85e-01 3.31e-03
SMAC, XIAP-regulated apoptotic response 7 2.94e-03 1.39e-02 0.64100 0.004120 6.41e-01 9.85e-01 3.31e-03
Common Pathway of Fibrin Clot Formation 13 5.18e-03 2.16e-02 0.63900 0.449000 4.56e-01 5.08e-03 4.45e-03
rRNA modification in the mitochondrion 8 1.24e-03 6.81e-03 0.63900 -0.639000 2.21e-03 1.74e-03 9.91e-01
Regulation of TP53 Activity through Association with Co-factors 11 2.71e-03 1.32e-02 0.63800 -0.235000 -5.93e-01 1.78e-01 6.61e-04
RHOT1 GTPase cycle 5 9.43e-02 1.95e-01 0.63700 0.561000 3.03e-01 2.98e-02 2.41e-01
Condensation of Prometaphase Chromosomes 11 5.11e-03 2.14e-02 0.63400 0.287000 5.66e-01 9.98e-02 1.16e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 5.63e-15 2.21e-13 0.63200 -0.598000 -2.06e-01 1.91e-15 6.09e-03
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 8.11e-02 1.75e-01 0.63100 -0.577000 -2.56e-01 2.55e-02 3.21e-01
Phosphorylation of Emi1 6 9.59e-02 1.97e-01 0.62800 0.435000 4.53e-01 6.51e-02 5.46e-02
Netrin mediated repulsion signals 5 1.32e-01 2.49e-01 0.62400 0.505000 3.66e-01 5.04e-02 1.56e-01
Translation initiation complex formation 58 1.34e-14 4.69e-13 0.62300 -0.592000 -1.94e-01 5.79e-15 1.06e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 7.78e-02 1.70e-01 0.62300 0.330000 5.28e-01 1.61e-01 2.50e-02
Regulation of IFNG signaling 14 3.86e-03 1.76e-02 0.62300 0.381000 4.93e-01 1.36e-02 1.41e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 6.07e-24 4.49e-22 0.62200 -0.587000 -2.05e-01 3.25e-24 4.01e-04
Interaction between L1 and Ankyrins 26 3.58e-05 3.27e-04 0.62100 0.490000 3.80e-01 1.50e-05 7.85e-04
Defective GALNT3 causes HFTC 8 1.48e-02 5.04e-02 0.61900 0.583000 2.10e-01 4.30e-03 3.05e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.39e-03 1.94e-02 0.61900 0.389000 4.81e-01 1.16e-02 1.84e-03
Cytosolic iron-sulfur cluster assembly 13 5.01e-03 2.13e-02 0.61500 -0.336000 -5.15e-01 3.57e-02 1.31e-03
Wax and plasmalogen biosynthesis 5 3.22e-02 9.05e-02 0.61500 0.065100 6.11e-01 8.01e-01 1.80e-02
RHO GTPases activate IQGAPs 25 5.09e-05 4.37e-04 0.61300 0.502000 3.51e-01 1.38e-05 2.36e-03
Ribosomal scanning and start codon recognition 58 7.49e-14 2.32e-12 0.61200 -0.579000 -2.00e-01 2.39e-14 8.42e-03
Termination of O-glycan biosynthesis 15 2.76e-03 1.33e-02 0.61100 0.501000 3.50e-01 7.89e-04 1.91e-02
STAT5 activation downstream of FLT3 ITD mutants 9 6.00e-03 2.42e-02 0.61000 0.590000 1.53e-01 2.17e-03 4.26e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.88e-04 2.53e-03 0.61000 0.578000 1.93e-01 1.05e-04 1.96e-01
Signaling by PDGFRA extracellular domain mutants 12 1.01e-02 3.79e-02 0.60800 0.363000 4.88e-01 2.94e-02 3.41e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.01e-02 3.79e-02 0.60800 0.363000 4.88e-01 2.94e-02 3.41e-03
EGFR Transactivation by Gastrin 7 7.01e-02 1.57e-01 0.60500 0.488000 3.58e-01 2.55e-02 1.01e-01
G2 Phase 5 1.64e-01 2.87e-01 0.60200 0.448000 4.03e-01 8.30e-02 1.19e-01
Regulation of RUNX1 Expression and Activity 18 1.06e-03 5.91e-03 0.59900 0.338000 4.95e-01 1.31e-02 2.80e-04
Selenoamino acid metabolism 115 2.66e-24 2.04e-22 0.59600 -0.556000 -2.16e-01 6.38e-25 6.14e-05
POLB-Dependent Long Patch Base Excision Repair 8 1.47e-02 5.00e-02 0.59500 -0.572000 -1.61e-01 5.05e-03 4.31e-01
Regulation of NFE2L2 gene expression 8 2.17e-03 1.10e-02 0.59200 0.590000 -4.23e-02 3.85e-03 8.36e-01
Relaxin receptors 5 3.13e-02 8.86e-02 0.59200 0.591000 1.69e-02 2.20e-02 9.48e-01
SARS-CoV-2 modulates host translation machinery 49 1.20e-10 2.72e-09 0.59100 -0.552000 -2.13e-01 2.33e-11 9.96e-03
GDP-fucose biosynthesis 6 1.23e-01 2.36e-01 0.59000 -0.380000 -4.51e-01 1.07e-01 5.56e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 3.81e-02 1.02e-01 0.59000 -0.588000 -4.50e-02 2.28e-02 8.62e-01
ChREBP activates metabolic gene expression 7 9.13e-02 1.91e-01 0.58700 0.425000 4.05e-01 5.13e-02 6.34e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 6.91e-02 1.56e-01 0.57700 -0.504000 -2.81e-01 2.10e-02 1.98e-01
Defects in biotin (Btn) metabolism 8 3.15e-02 8.93e-02 0.57700 -0.533000 -2.20e-01 9.03e-03 2.81e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 1.21e-02 4.35e-02 0.57600 0.161000 5.53e-01 4.03e-01 4.04e-03
Mitochondrial translation initiation 90 5.83e-23 3.86e-21 0.57500 -0.568000 -8.76e-02 1.09e-20 1.51e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.12e-27 1.27e-25 0.57200 -0.565000 -9.01e-02 7.74e-25 1.01e-01
Signaling by LTK in cancer 7 1.03e-01 2.09e-01 0.57200 0.417000 3.91e-01 5.62e-02 7.31e-02
Mitochondrial translation elongation 90 1.56e-21 9.09e-20 0.57000 -0.559000 -1.11e-01 4.25e-20 6.93e-02
Regulation of NPAS4 gene expression 11 1.68e-02 5.49e-02 0.57000 0.279000 4.97e-01 1.09e-01 4.32e-03
GAB1 signalosome 14 7.23e-04 4.25e-03 0.57000 0.556000 1.25e-01 3.15e-04 4.19e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 6.06e-33 2.33e-30 0.56800 -0.524000 -2.20e-01 9.60e-34 3.69e-07
Interleukin-20 family signaling 17 2.13e-03 1.08e-02 0.56800 0.289000 4.89e-01 3.94e-02 4.76e-04
Vitamin B1 (thiamin) metabolism 5 1.35e-01 2.54e-01 0.56700 -0.515000 -2.37e-01 4.59e-02 3.60e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 8.54e-24 5.86e-22 0.56700 -0.542000 -1.65e-01 1.39e-23 2.36e-03
Nonsense-Mediated Decay (NMD) 114 8.54e-24 5.86e-22 0.56700 -0.542000 -1.65e-01 1.39e-23 2.36e-03
rRNA processing in the nucleus and cytosol 189 2.33e-34 1.49e-31 0.56500 -0.521000 -2.19e-01 3.75e-35 2.02e-07
Sodium/Proton exchangers 7 9.42e-02 1.95e-01 0.56400 0.465000 3.20e-01 3.32e-02 1.43e-01
Tandem pore domain potassium channels 5 2.02e-01 3.30e-01 0.56400 0.362000 4.32e-01 1.61e-01 9.40e-02
Signaling by FLT3 ITD and TKD mutants 15 4.21e-03 1.88e-02 0.56300 0.493000 2.71e-01 9.51e-04 6.88e-02
Formation of the nephric duct 8 8.14e-02 1.76e-01 0.56200 0.408000 3.88e-01 4.59e-02 5.76e-02
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 3.66e-02 9.89e-02 0.56000 -0.147000 -5.40e-01 5.02e-01 1.33e-02
Mitochondrial translation termination 90 3.95e-21 2.23e-19 0.56000 -0.551000 -1.00e-01 1.65e-19 1.01e-01
Mitochondrial translation 96 2.03e-22 1.26e-20 0.55900 -0.550000 -1.01e-01 1.12e-20 8.64e-02
Regulation of gene expression by Hypoxia-inducible Factor 8 1.45e-02 4.94e-02 0.55900 0.551000 9.39e-02 6.92e-03 6.46e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.50e-02 5.08e-02 0.55800 0.330000 4.49e-01 3.91e-02 5.02e-03
Synthesis of wybutosine at G37 of tRNA(Phe) 6 2.65e-02 7.73e-02 0.55700 -0.556000 -2.36e-02 1.83e-02 9.20e-01
Synthesis of UDP-N-acetyl-glucosamine 8 4.48e-02 1.15e-01 0.55500 -0.507000 -2.25e-01 1.30e-02 2.70e-01
Diseases of Mismatch Repair (MMR) 5 4.40e-02 1.13e-01 0.55400 0.001410 5.54e-01 9.96e-01 3.19e-02
Influenza Viral RNA Transcription and Replication 135 5.72e-25 4.57e-23 0.55300 -0.519000 -1.91e-01 2.07e-25 1.22e-04
OAS antiviral response 8 2.90e-03 1.38e-02 0.55000 -0.099400 5.41e-01 6.27e-01 8.03e-03
G0 and Early G1 27 1.73e-04 1.27e-03 0.55000 0.310000 4.54e-01 5.36e-03 4.40e-05
Complex III assembly 23 3.72e-04 2.45e-03 0.54900 -0.478000 -2.71e-01 7.30e-05 2.45e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.97e-02 8.48e-02 0.54600 0.252000 4.84e-01 1.67e-01 8.00e-03
GRB2 events in EGFR signaling 10 5.57e-03 2.29e-02 0.54600 0.540000 7.75e-02 3.11e-03 6.71e-01
ALK mutants bind TKIs 11 3.47e-02 9.50e-02 0.54400 0.328000 4.35e-01 6.00e-02 1.25e-02
RUNX3 regulates WNT signaling 8 7.68e-02 1.68e-01 0.54200 0.458000 2.90e-01 2.48e-02 1.55e-01
Sulfide oxidation to sulfate 5 1.77e-01 3.02e-01 0.54200 -0.481000 -2.50e-01 6.26e-02 3.32e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 7.34e-02 1.63e-01 0.54100 0.371000 3.93e-01 5.37e-02 4.10e-02
RHO GTPases activate KTN1 11 3.36e-02 9.30e-02 0.54000 0.444000 3.07e-01 1.07e-02 7.74e-02
Regulation of CDH19 Expression and Function 5 1.32e-02 4.61e-02 0.54000 0.280000 -4.61e-01 2.78e-01 7.40e-02
Biosynthesis of Lipoxins (LX) 6 7.62e-02 1.67e-01 0.53800 0.517000 1.49e-01 2.82e-02 5.27e-01
NFE2L2 regulating tumorigenic genes 11 2.88e-03 1.38e-02 0.53800 0.536000 5.26e-02 2.09e-03 7.62e-01
Polo-like kinase mediated events 16 9.50e-03 3.60e-02 0.53500 0.335000 4.18e-01 2.05e-02 3.79e-03
RHO GTPases Activate NADPH Oxidases 21 2.23e-03 1.12e-02 0.53500 0.334000 4.18e-01 8.09e-03 9.07e-04
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 2.39e-01 3.69e-01 0.53500 -0.404000 -3.51e-01 1.18e-01 1.74e-01
Defective HLCS causes multiple carboxylase deficiency 7 8.32e-02 1.78e-01 0.53400 -0.486000 -2.22e-01 2.61e-02 3.10e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 5.04e-02 1.23e-01 0.53300 -0.528000 -7.40e-02 2.51e-02 7.54e-01
APOBEC3G mediated resistance to HIV-1 infection 5 4.90e-02 1.21e-01 0.53200 -0.531000 2.31e-02 3.96e-02 9.29e-01
rRNA processing 213 6.49e-34 3.12e-31 0.53000 -0.488000 -2.06e-01 9.90e-35 2.06e-07
Propionyl-CoA catabolism 5 1.12e-01 2.20e-01 0.52900 -0.515000 -1.24e-01 4.63e-02 6.31e-01
Interleukin-9 signaling 8 7.16e-02 1.60e-01 0.52900 0.244000 4.69e-01 2.31e-01 2.17e-02
Post-transcriptional silencing by small RNAs 7 1.36e-01 2.54e-01 0.52700 0.318000 4.20e-01 1.45e-01 5.45e-02
Kidney development 16 1.27e-02 4.48e-02 0.52400 0.389000 3.51e-01 7.06e-03 1.51e-02
Ca2+ activated K+ channels 6 3.81e-02 1.02e-01 0.52300 -0.011200 -5.22e-01 9.62e-01 2.67e-02
Signaling by PDGFR in disease 19 2.70e-03 1.32e-02 0.51700 0.246000 4.55e-01 6.38e-02 5.87e-04
Maturation of spike protein 9683686 5 2.66e-01 3.94e-01 0.51700 -0.369000 -3.62e-01 1.53e-01 1.61e-01
Phase 4 - resting membrane potential 9 8.87e-02 1.88e-01 0.51700 0.398000 3.30e-01 3.88e-02 8.63e-02
Toxicity of botulinum toxin type D (botD) 5 2.04e-01 3.31e-01 0.51700 -0.234000 -4.61e-01 3.64e-01 7.45e-02
Toxicity of botulinum toxin type F (botF) 5 2.04e-01 3.31e-01 0.51700 -0.234000 -4.61e-01 3.64e-01 7.45e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.90e-02 6.03e-02 0.51600 -0.484000 -1.81e-01 5.46e-03 2.99e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 2.13e-01 3.41e-01 0.51600 -0.245000 -4.54e-01 3.43e-01 7.88e-02
tRNA modification in the mitochondrion 9 9.31e-02 1.94e-01 0.51500 -0.378000 -3.51e-01 4.98e-02 6.83e-02
CD22 mediated BCR regulation 58 1.36e-08 2.43e-07 0.51400 0.237000 4.57e-01 1.81e-03 1.75e-09
Cobalamin (Cbl) metabolism 7 2.43e-02 7.19e-02 0.51100 0.002170 5.11e-01 9.92e-01 1.92e-02
Reduction of cytosolic Ca++ levels 9 8.87e-02 1.88e-01 0.50900 0.410000 3.02e-01 3.31e-02 1.17e-01
Defective C1GALT1C1 causes TNPS 9 6.15e-02 1.44e-01 0.50900 0.455000 2.30e-01 1.82e-02 2.33e-01
Triglyceride catabolism 15 2.05e-02 6.36e-02 0.50800 0.330000 3.87e-01 2.69e-02 9.51e-03
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 6.81e-02 1.55e-01 0.50800 -0.508000 1.00e-02 4.91e-02 9.69e-01
Displacement of DNA glycosylase by APEX1 9 6.39e-02 1.47e-01 0.50700 -0.452000 -2.31e-01 1.90e-02 2.29e-01
Eicosanoids 6 9.77e-02 2.00e-01 0.50700 0.489000 1.33e-01 3.80e-02 5.73e-01
Methionine salvage pathway 6 5.71e-02 1.36e-01 0.50600 -0.504000 -4.17e-02 3.26e-02 8.60e-01
Influenza Infection 154 3.33e-25 2.78e-23 0.50500 -0.482000 -1.52e-01 4.71e-25 1.16e-03
FCGR activation 76 1.68e-11 4.37e-10 0.50500 0.197000 4.65e-01 2.93e-03 2.46e-12
Translation 293 5.40e-55 1.04e-51 0.50500 -0.497000 -8.57e-02 9.11e-49 1.16e-02
Synthesis of glycosylphosphatidylinositol (GPI) 18 6.92e-03 2.75e-02 0.50500 -0.425000 -2.72e-01 1.81e-03 4.55e-02
MASTL Facilitates Mitotic Progression 10 2.25e-02 6.83e-02 0.50400 0.136000 4.85e-01 4.55e-01 7.87e-03
Induction of Cell-Cell Fusion 8 1.08e-01 2.15e-01 0.50200 0.428000 2.61e-01 3.59e-02 2.01e-01
Role of LAT2/NTAL/LAB on calcium mobilization 77 1.20e-10 2.72e-09 0.50000 0.226000 4.45e-01 5.92e-04 1.39e-11
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.24e-01 2.38e-01 0.50000 -0.088000 -4.92e-01 7.33e-01 5.69e-02
Signaling by FLT3 fusion proteins 18 1.09e-02 4.01e-02 0.49900 0.385000 3.18e-01 4.72e-03 1.96e-02
SLBP independent Processing of Histone Pre-mRNAs 10 3.72e-02 9.99e-02 0.49800 -0.464000 -1.82e-01 1.11e-02 3.19e-01
Transcriptional regulation of testis differentiation 5 1.16e-01 2.25e-01 0.49800 -0.071300 -4.92e-01 7.82e-01 5.65e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 1.53e-02 5.15e-02 0.49600 -0.452000 2.05e-01 5.55e-02 3.84e-01
Axonal growth inhibition (RHOA activation) 7 1.10e-01 2.18e-01 0.49400 0.455000 1.90e-01 3.70e-02 3.83e-01
p75NTR regulates axonogenesis 7 1.10e-01 2.18e-01 0.49400 0.455000 1.90e-01 3.70e-02 3.83e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.45e-02 9.45e-02 0.49000 0.321000 3.70e-01 3.73e-02 1.64e-02
RHO GTPases Activate WASPs and WAVEs 35 1.20e-04 9.32e-04 0.49000 0.270000 4.09e-01 5.67e-03 2.80e-05
Antimicrobial peptides 33 3.92e-04 2.54e-03 0.49000 0.342000 3.51e-01 6.62e-04 4.87e-04
CS/DS degradation 9 9.62e-02 1.97e-01 0.49000 -0.266000 -4.12e-01 1.68e-01 3.24e-02
SUMO is proteolytically processed 6 1.82e-02 5.84e-02 0.48900 -0.189000 4.51e-01 4.22e-01 5.56e-02
Transcriptional regulation of granulopoiesis 44 2.39e-05 2.32e-04 0.48900 0.308000 3.80e-01 4.13e-04 1.29e-05
Formyl peptide receptors bind formyl peptides and many other ligands 7 6.05e-02 1.42e-01 0.48800 0.084300 4.81e-01 6.99e-01 2.76e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 2.04e-10 4.44e-09 0.48600 0.239000 4.23e-01 1.68e-04 2.57e-11
Regulation of PTEN mRNA translation 12 4.07e-02 1.07e-01 0.48500 0.242000 4.21e-01 1.47e-01 1.16e-02
SHC1 events in EGFR signaling 11 1.22e-02 4.37e-02 0.48400 0.478000 7.74e-02 6.05e-03 6.57e-01
Scavenging of heme from plasma 70 4.69e-09 9.11e-08 0.48400 0.227000 4.28e-01 1.04e-03 5.93e-10
PI3K/AKT activation 8 6.99e-02 1.57e-01 0.48400 0.460000 1.50e-01 2.43e-02 4.62e-01
CHL1 interactions 8 1.49e-01 2.71e-01 0.48400 0.378000 3.02e-01 6.42e-02 1.39e-01
Tight junction interactions 17 1.83e-02 5.85e-02 0.48300 -0.373000 -3.07e-01 7.79e-03 2.83e-02
Signaling by RNF43 mutants 7 1.15e-01 2.24e-01 0.48300 0.449000 1.77e-01 3.95e-02 4.19e-01
DNA replication initiation 8 1.20e-01 2.32e-01 0.48300 -0.420000 -2.38e-01 3.97e-02 2.44e-01
G1/S-Specific Transcription 29 2.38e-04 1.66e-03 0.48200 0.203000 4.37e-01 5.88e-02 4.55e-05
Prolonged ERK activation events 13 4.89e-02 1.21e-01 0.48200 0.314000 3.65e-01 4.98e-02 2.27e-02
Formation of the active cofactor, UDP-glucuronate 5 2.36e-01 3.66e-01 0.48100 0.200000 4.38e-01 4.40e-01 9.00e-02
FCGR3A-mediated phagocytosis 121 8.67e-15 3.14e-13 0.48100 0.228000 4.23e-01 1.44e-05 8.70e-16
Leishmania phagocytosis 121 8.67e-15 3.14e-13 0.48100 0.228000 4.23e-01 1.44e-05 8.70e-16
Parasite infection 121 8.67e-15 3.14e-13 0.48100 0.228000 4.23e-01 1.44e-05 8.70e-16
Role of ABL in ROBO-SLIT signaling 6 2.29e-01 3.59e-01 0.48000 0.398000 2.70e-01 9.17e-02 2.52e-01
Mitochondrial protein import 63 1.61e-09 3.33e-08 0.47900 -0.454000 -1.54e-01 4.56e-10 3.47e-02
CREB phosphorylation 7 8.27e-02 1.78e-01 0.47900 0.115000 4.65e-01 5.99e-01 3.31e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 3.24e-01 4.57e-01 0.47600 0.348000 3.25e-01 1.78e-01 2.08e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 8.41e-03 3.24e-02 0.47600 -0.394000 2.66e-01 7.08e-02 2.22e-01
RUNX1 regulates estrogen receptor mediated transcription 6 2.53e-01 3.82e-01 0.47500 0.297000 3.71e-01 2.08e-01 1.16e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 3.57e-02 9.70e-02 0.47500 -0.240000 4.10e-01 3.52e-01 1.13e-01
FCERI mediated Ca+2 mobilization 92 2.60e-11 6.49e-10 0.47500 0.220000 4.21e-01 2.69e-04 2.92e-12
Processing of SMDT1 15 2.58e-03 1.27e-02 0.47500 -0.470000 -6.28e-02 1.61e-03 6.74e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.26e-02 6.83e-02 0.47400 0.319000 3.50e-01 2.27e-02 1.25e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.26e-02 6.83e-02 0.47400 0.319000 3.50e-01 2.27e-02 1.25e-02
NFE2L2 regulating MDR associated enzymes 8 3.63e-02 9.84e-02 0.47300 0.471000 4.23e-02 2.10e-02 8.36e-01
RUNX1 regulates expression of components of tight junctions 5 3.25e-01 4.57e-01 0.47300 0.361000 3.06e-01 1.62e-01 2.37e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 6.91e-04 4.11e-03 0.47300 0.255000 3.98e-01 1.56e-02 1.60e-04
Signal attenuation 9 1.37e-02 4.76e-02 0.47300 0.472000 -2.10e-02 1.42e-02 9.13e-01
Reelin signalling pathway 5 2.21e-01 3.49e-01 0.47200 0.164000 4.43e-01 5.25e-01 8.65e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 5.33e-03 2.22e-02 0.47200 0.133000 4.52e-01 3.57e-01 1.73e-03
N-glycan antennae elongation in the medial/trans-Golgi 20 1.22e-02 4.38e-02 0.47100 0.323000 3.43e-01 1.23e-02 7.91e-03
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 1.23e-02 4.40e-02 0.47000 0.427000 1.97e-01 3.09e-03 1.73e-01
Platelet Adhesion to exposed collagen 14 4.19e-02 1.09e-01 0.46900 0.375000 2.82e-01 1.52e-02 6.76e-02
Platelet calcium homeostasis 22 7.18e-03 2.83e-02 0.46900 0.369000 2.89e-01 2.71e-03 1.89e-02
Nephrin family interactions 19 1.63e-02 5.34e-02 0.46800 0.328000 3.34e-01 1.34e-02 1.17e-02
Regulation of actin dynamics for phagocytic cup formation 123 8.70e-14 2.61e-12 0.46800 0.238000 4.03e-01 5.27e-06 1.11e-14
rRNA modification in the nucleus and cytosol 59 1.69e-07 2.60e-06 0.46800 -0.420000 -2.06e-01 2.38e-08 6.14e-03
Translocation of ZAP-70 to Immunological synapse 24 3.92e-04 2.54e-03 0.46500 -0.449000 -1.21e-01 1.40e-04 3.05e-01
Linoleic acid (LA) metabolism 7 1.62e-01 2.85e-01 0.46400 0.417000 2.05e-01 5.63e-02 3.48e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 1.01e-02 3.78e-02 0.46300 -0.455000 -8.79e-02 4.52e-03 5.83e-01
Thyroxine biosynthesis 5 2.05e-01 3.32e-01 0.46300 -0.129000 -4.45e-01 6.17e-01 8.51e-02
Cross-presentation of particulate exogenous antigens (phagosomes) 8 1.76e-01 3.02e-01 0.46200 0.360000 2.90e-01 7.76e-02 1.56e-01
COPI-independent Golgi-to-ER retrograde traffic 45 4.47e-05 4.00e-04 0.46200 0.271000 3.75e-01 1.69e-03 1.36e-05
Activated NTRK2 signals through FRS2 and FRS3 8 1.84e-01 3.10e-01 0.46200 0.328000 3.26e-01 1.08e-01 1.11e-01
O-linked glycosylation of mucins 46 3.86e-05 3.46e-04 0.46000 0.374000 2.68e-01 1.15e-05 1.63e-03
Olfactory Signaling Pathway 54 6.60e-09 1.25e-07 0.46000 0.452000 8.68e-02 9.22e-09 2.70e-01
Biotin transport and metabolism 11 3.87e-02 1.03e-01 0.46000 -0.435000 -1.49e-01 1.24e-02 3.94e-01
Crosslinking of collagen fibrils 12 5.67e-03 2.31e-02 0.45900 0.000698 -4.59e-01 9.97e-01 5.86e-03
Processing and activation of SUMO 10 1.57e-03 8.43e-03 0.45900 -0.361000 2.84e-01 4.79e-02 1.20e-01
Degradation of cysteine and homocysteine 12 8.19e-02 1.76e-01 0.45800 -0.335000 -3.12e-01 4.42e-02 6.09e-02
DNA methylation 18 2.21e-02 6.77e-02 0.45700 0.287000 3.56e-01 3.49e-02 8.99e-03
Transcription of E2F targets under negative control by DREAM complex 19 4.74e-03 2.04e-02 0.45700 0.160000 4.28e-01 2.28e-01 1.25e-03
Interferon alpha/beta signaling 63 1.29e-15 5.29e-14 0.45700 -0.130000 4.38e-01 7.37e-02 1.88e-09
Formation of the beta-catenin:TCF transactivating complex 44 9.71e-05 7.74e-04 0.45600 0.353000 2.89e-01 5.15e-05 8.93e-04
Expression and translocation of olfactory receptors 49 6.19e-08 1.05e-06 0.45600 0.447000 9.01e-02 6.23e-08 2.75e-01
Keratan sulfate biosynthesis 19 2.00e-02 6.30e-02 0.45500 0.337000 3.06e-01 1.10e-02 2.09e-02
Diseases of branched-chain amino acid catabolism 13 1.64e-03 8.75e-03 0.45500 -0.449000 7.55e-02 5.10e-03 6.37e-01
AKT phosphorylates targets in the nucleus 9 5.12e-02 1.25e-01 0.45500 -0.098600 -4.44e-01 6.08e-01 2.11e-02
Serine biosynthesis 8 1.94e-01 3.21e-01 0.45500 0.325000 3.18e-01 1.12e-01 1.19e-01
Uptake and function of anthrax toxins 10 1.27e-01 2.43e-01 0.45500 0.339000 3.04e-01 6.37e-02 9.63e-02
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 2.41e-02 7.15e-02 0.45500 0.120000 -4.38e-01 5.81e-01 4.46e-02
Defective GALNT12 causes CRCS1 8 7.29e-02 1.62e-01 0.45400 0.443000 1.01e-01 3.00e-02 6.22e-01
FCGR3A-mediated IL10 synthesis 99 4.64e-11 1.11e-09 0.45400 0.213000 4.01e-01 2.53e-04 5.30e-12
Gap junction assembly 16 2.55e-02 7.49e-02 0.45300 0.389000 2.31e-01 6.99e-03 1.10e-01
MECP2 regulates neuronal receptors and channels 13 5.86e-02 1.38e-01 0.45100 0.250000 3.76e-01 1.19e-01 1.89e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 2.96e-01 4.28e-01 0.45000 -0.342000 -2.93e-01 1.47e-01 2.14e-01
Regulation of CDH11 mRNA translation by microRNAs 8 1.45e-01 2.65e-01 0.44800 0.200000 4.01e-01 3.27e-01 4.95e-02
Regulation of NPAS4 mRNA translation 8 1.45e-01 2.65e-01 0.44800 0.200000 4.01e-01 3.27e-01 4.95e-02
Cargo concentration in the ER 31 1.66e-03 8.80e-03 0.44800 0.270000 3.57e-01 9.15e-03 5.74e-04
MET activates RAP1 and RAC1 10 1.38e-01 2.57e-01 0.44700 0.308000 3.24e-01 9.14e-02 7.62e-02
Frs2-mediated activation 11 1.11e-01 2.19e-01 0.44600 0.291000 3.39e-01 9.49e-02 5.19e-02
MAPK1 (ERK2) activation 8 1.62e-01 2.86e-01 0.44600 0.219000 3.89e-01 2.83e-01 5.70e-02
Erythrocytes take up carbon dioxide and release oxygen 11 6.86e-02 1.56e-01 0.44600 0.403000 1.92e-01 2.07e-02 2.70e-01
O2/CO2 exchange in erythrocytes 11 6.86e-02 1.56e-01 0.44600 0.403000 1.92e-01 2.07e-02 2.70e-01
RHO GTPases activate PAKs 20 1.95e-02 6.18e-02 0.44500 0.305000 3.25e-01 1.83e-02 1.19e-02
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 2.45e-01 3.72e-01 0.44500 0.347000 2.79e-01 1.12e-01 2.00e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.10e-01 2.18e-01 0.44500 0.345000 2.81e-01 4.74e-02 1.07e-01
Anti-inflammatory response favouring Leishmania parasite infection 131 9.18e-13 2.59e-11 0.44500 0.245000 3.71e-01 1.27e-06 2.13e-13
Leishmania parasite growth and survival 131 9.18e-13 2.59e-11 0.44500 0.245000 3.71e-01 1.27e-06 2.13e-13
Regulation of HMOX1 expression and activity 5 4.83e-02 1.20e-01 0.44500 0.346000 -2.79e-01 1.80e-01 2.80e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 8.20e-05 6.65e-04 0.44400 0.298000 3.30e-01 3.58e-04 7.80e-05
NADE modulates death signalling 5 1.70e-01 2.95e-01 0.44300 0.050500 4.40e-01 8.45e-01 8.81e-02
EPHB-mediated forward signaling 38 1.83e-04 1.33e-03 0.44200 0.211000 3.89e-01 2.43e-02 3.38e-05
Gain-of-function MRAS complexes activate RAF signaling 8 2.03e-01 3.30e-01 0.44200 0.272000 3.48e-01 1.83e-01 8.80e-02
SHOC2 M1731 mutant abolishes MRAS complex function 8 2.03e-01 3.30e-01 0.44200 0.272000 3.48e-01 1.83e-01 8.80e-02
Signaling by MRAS-complex mutants 8 2.03e-01 3.30e-01 0.44200 0.272000 3.48e-01 1.83e-01 8.80e-02
Elevation of cytosolic Ca2+ levels 13 7.80e-02 1.70e-01 0.44100 0.341000 2.80e-01 3.35e-02 8.05e-02
G beta:gamma signalling through BTK 15 4.35e-02 1.12e-01 0.44000 0.240000 3.69e-01 1.07e-01 1.34e-02
Signaling by Erythropoietin 24 7.88e-03 3.06e-02 0.44000 0.357000 2.56e-01 2.45e-03 2.99e-02
Fcgamma receptor (FCGR) dependent phagocytosis 147 2.06e-14 6.81e-13 0.43900 0.225000 3.77e-01 2.43e-06 2.72e-15
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 5.80e-02 1.37e-01 0.43900 0.397000 1.87e-01 1.72e-02 2.62e-01
Transport of connexons to the plasma membrane 12 5.80e-02 1.37e-01 0.43900 0.397000 1.87e-01 1.72e-02 2.62e-01
SOS-mediated signalling 7 6.88e-02 1.56e-01 0.43900 0.439000 1.17e-02 4.44e-02 9.57e-01
Interleukin receptor SHC signaling 23 1.26e-02 4.46e-02 0.43800 0.306000 3.14e-01 1.11e-02 9.08e-03
Cyclin A/B1/B2 associated events during G2/M transition 25 4.16e-03 1.86e-02 0.43800 0.214000 3.82e-01 6.40e-02 9.43e-04
Anchoring fibril formation 7 1.62e-02 5.32e-02 0.43700 0.327000 -2.90e-01 1.34e-01 1.83e-01
Translesion synthesis by POLI 17 1.70e-03 9.01e-03 0.43600 -0.436000 -1.41e-02 1.86e-03 9.20e-01
Integration of provirus 9 1.30e-02 4.58e-02 0.43600 -0.423000 1.06e-01 2.80e-02 5.81e-01
Phosphate bond hydrolysis by NUDT proteins 7 7.33e-02 1.63e-01 0.43600 -0.435000 -1.53e-02 4.60e-02 9.44e-01
ADP signalling through P2Y purinoceptor 12 18 2.35e-02 7.04e-02 0.43600 0.230000 3.70e-01 9.14e-02 6.58e-03
RAS signaling downstream of NF1 loss-of-function variants 7 2.69e-01 3.97e-01 0.43500 0.301000 3.14e-01 1.68e-01 1.50e-01
Presynaptic depolarization and calcium channel opening 8 2.04e-01 3.31e-01 0.43500 -0.250000 -3.56e-01 2.21e-01 8.14e-02
Signaling by MAPK mutants 6 1.97e-01 3.24e-01 0.43500 -0.132000 -4.14e-01 5.77e-01 7.89e-02
Regulation of PTEN localization 9 9.55e-02 1.96e-01 0.43300 0.142000 4.09e-01 4.61e-01 3.34e-02
DARPP-32 events 22 1.37e-02 4.74e-02 0.43300 0.255000 3.50e-01 3.86e-02 4.45e-03
Interleukin-10 signaling 36 6.63e-09 1.25e-07 0.43300 0.399000 -1.69e-01 3.48e-05 7.98e-02
Defective LFNG causes SCDO3 5 3.58e-01 4.90e-01 0.43300 0.367000 2.29e-01 1.55e-01 3.76e-01
Classical antibody-mediated complement activation 69 2.92e-07 4.31e-06 0.43200 0.203000 3.82e-01 3.61e-03 4.14e-08
Initiation of Nuclear Envelope (NE) Reformation 19 2.03e-02 6.33e-02 0.43000 0.223000 3.68e-01 9.22e-02 5.49e-03
Dectin-2 family 18 3.69e-02 9.95e-02 0.42900 0.287000 3.19e-01 3.48e-02 1.92e-02
Purine ribonucleoside monophosphate biosynthesis 9 8.05e-02 1.75e-01 0.42900 -0.415000 -1.10e-01 3.12e-02 5.68e-01
Kinesins 51 6.29e-05 5.23e-04 0.42900 0.343000 2.57e-01 2.20e-05 1.50e-03
RHO GTPases Activate ROCKs 18 3.65e-02 9.88e-02 0.42900 0.281000 3.24e-01 3.91e-02 1.73e-02
FCERI mediated MAPK activation 93 3.15e-09 6.18e-08 0.42800 0.207000 3.75e-01 5.43e-04 4.09e-10
Sulfur amino acid metabolism 22 1.61e-02 5.32e-02 0.42800 -0.340000 -2.59e-01 5.77e-03 3.52e-02
Erythropoietin activates RAS 13 9.60e-02 1.97e-01 0.42700 0.305000 2.98e-01 5.65e-02 6.28e-02
Digestion 5 2.32e-01 3.62e-01 0.42500 0.416000 8.63e-02 1.07e-01 7.38e-01
Negative regulation of MET activity 18 3.56e-02 9.69e-02 0.42400 0.255000 3.39e-01 6.13e-02 1.28e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 3.65e-04 2.41e-03 0.42300 0.272000 3.24e-01 1.81e-03 1.97e-04
Regulation of KIT signaling 15 6.71e-02 1.53e-01 0.42200 0.266000 3.27e-01 7.42e-02 2.82e-02
Signaling by Leptin 10 8.19e-02 1.76e-01 0.41900 0.399000 1.29e-01 2.90e-02 4.80e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 4.05e-01 5.28e-01 0.41800 0.248000 3.36e-01 3.37e-01 1.93e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 4.05e-01 5.28e-01 0.41800 0.248000 3.36e-01 3.37e-01 1.93e-01
Proton-coupled monocarboxylate transport 6 3.40e-01 4.72e-01 0.41800 0.334000 2.51e-01 1.56e-01 2.88e-01
E2F-enabled inhibition of pre-replication complex formation 9 6.37e-02 1.47e-01 0.41700 0.055600 4.13e-01 7.73e-01 3.19e-02
2-LTR circle formation 7 2.49e-02 7.34e-02 0.41600 -0.332000 2.50e-01 1.28e-01 2.51e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 5.66e-03 2.31e-02 0.41600 0.401000 1.12e-01 1.92e-03 3.86e-01
Cellular response to starvation 148 1.29e-15 5.29e-14 0.41600 -0.389000 -1.47e-01 2.93e-16 2.08e-03
Glucuronidation 8 1.87e-01 3.13e-01 0.41600 0.182000 3.74e-01 3.73e-01 6.71e-02
Interactions of Vpr with host cellular proteins 37 1.06e-03 5.91e-03 0.41600 -0.346000 -2.30e-01 2.65e-04 1.56e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 5.99e-02 1.41e-01 0.41600 0.045400 4.13e-01 8.14e-01 3.19e-02
EGFR downregulation 26 1.37e-03 7.45e-03 0.41600 0.399000 1.18e-01 4.35e-04 2.99e-01
Maturation of hRSV A proteins 13 1.97e-02 6.21e-02 0.41500 0.057600 4.11e-01 7.19e-01 1.02e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 3.59e-03 1.65e-02 0.41500 0.256000 3.27e-01 1.22e-02 1.36e-03
Glycosphingolipid biosynthesis 16 5.15e-02 1.26e-01 0.41500 0.347000 2.27e-01 1.62e-02 1.17e-01
Prostanoid ligand receptors 8 2.23e-01 3.52e-01 0.41400 0.350000 2.21e-01 8.61e-02 2.79e-01
Protein lipoylation 10 8.10e-03 3.13e-02 0.41400 -0.380000 1.65e-01 3.76e-02 3.65e-01
Growth hormone receptor signaling 20 2.94e-02 8.41e-02 0.41400 0.330000 2.49e-01 1.05e-02 5.40e-02
RHO GTPases activate CIT 18 4.13e-02 1.08e-01 0.41300 0.245000 3.33e-01 7.21e-02 1.45e-02
Telomere C-strand synthesis initiation 13 1.43e-02 4.89e-02 0.41300 -0.412000 -2.42e-02 1.01e-02 8.80e-01
Mitochondrial calcium ion transport 22 4.09e-03 1.84e-02 0.41300 -0.396000 -1.17e-01 1.31e-03 3.42e-01
Role of phospholipids in phagocytosis 88 1.09e-08 2.00e-07 0.41200 0.176000 3.73e-01 4.34e-03 1.47e-09
MAPK3 (ERK1) activation 9 2.04e-01 3.31e-01 0.41100 0.238000 3.35e-01 2.16e-01 8.20e-02
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 7.53e-02 1.66e-01 0.41000 -0.133000 -3.88e-01 4.45e-01 2.57e-02
Formation of Fibrin Clot (Clotting Cascade) 26 1.27e-02 4.49e-02 0.41000 0.272000 3.07e-01 1.63e-02 6.69e-03
Gamma-carboxylation of protein precursors 6 3.53e-01 4.88e-01 0.41000 0.246000 3.28e-01 2.96e-01 1.64e-01
Fatty acids 6 2.13e-01 3.41e-01 0.41000 0.397000 1.02e-01 9.22e-02 6.66e-01
Regulation of ornithine decarboxylase (ODC) 38 4.56e-05 4.04e-04 0.41000 0.094500 3.99e-01 3.13e-01 2.10e-05
Cytochrome c-mediated apoptotic response 13 2.49e-03 1.23e-02 0.41000 -0.148000 3.82e-01 3.55e-01 1.71e-02
Signalling to ERKs 32 4.91e-03 2.10e-02 0.41000 0.296000 2.83e-01 3.70e-03 5.65e-03
FCERI mediated NF-kB activation 129 8.18e-13 2.38e-11 0.41000 0.158000 3.78e-01 1.93e-03 1.22e-13
Downregulation of ERBB2:ERBB3 signaling 12 1.17e-01 2.27e-01 0.40900 -0.340000 -2.27e-01 4.13e-02 1.73e-01
Binding and Uptake of Ligands by Scavenger Receptors 90 1.54e-07 2.38e-06 0.40800 0.234000 3.34e-01 1.25e-04 4.40e-08
VxPx cargo-targeting to cilium 19 4.17e-02 1.08e-01 0.40700 0.261000 3.13e-01 4.93e-02 1.81e-02
Golgi-to-ER retrograde transport 123 4.46e-10 9.63e-09 0.40700 0.230000 3.36e-01 1.02e-05 1.23e-10
RNA Polymerase III Chain Elongation 18 1.40e-02 4.80e-02 0.40600 -0.387000 -1.21e-01 4.44e-03 3.74e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 2.04e-02 6.36e-02 0.40600 0.021200 -4.05e-01 9.03e-01 1.99e-02
Defective CFTR causes cystic fibrosis 47 3.62e-06 4.35e-05 0.40600 0.082100 3.97e-01 3.30e-01 2.46e-06
Synthesis of 15-eicosatetraenoic acid derivatives 6 3.68e-01 4.99e-01 0.40500 -0.253000 -3.16e-01 2.83e-01 1.80e-01
SHC-related events triggered by IGF1R 7 3.16e-01 4.50e-01 0.40500 0.308000 2.62e-01 1.58e-01 2.29e-01
Attachment and Entry 9694614 13 8.48e-02 1.81e-01 0.40500 0.356000 1.93e-01 2.64e-02 2.28e-01
Translesion synthesis by REV1 16 3.66e-03 1.67e-02 0.40500 -0.404000 1.98e-02 5.12e-03 8.91e-01
ADP signalling through P2Y purinoceptor 1 21 3.21e-02 9.03e-02 0.40400 0.308000 2.62e-01 1.46e-02 3.77e-02
Downstream signal transduction 27 1.31e-02 4.59e-02 0.40300 0.287000 2.83e-01 9.85e-03 1.10e-02
Chromatin modifications during the maternal to zygotic transition (MZT) 23 2.50e-02 7.35e-02 0.40300 0.287000 2.82e-01 1.71e-02 1.91e-02
CREB3 factors activate genes 6 2.44e-01 3.71e-01 0.40200 -0.385000 -1.18e-01 1.03e-01 6.18e-01
Regulation of expression of SLITs and ROBOs 149 1.71e-19 8.64e-18 0.40200 -0.400000 -4.60e-02 3.61e-17 3.33e-01
Arachidonate production from DAG 5 4.09e-01 5.33e-01 0.40200 -0.343000 -2.09e-01 1.84e-01 4.19e-01
Early Phase of HIV Life Cycle 14 2.25e-02 6.83e-02 0.40100 -0.395000 -6.89e-02 1.05e-02 6.55e-01
Glucagon signaling in metabolic regulation 26 1.61e-02 5.32e-02 0.40000 0.277000 2.89e-01 1.45e-02 1.07e-02
Hh mutants are degraded by ERAD 42 1.80e-05 1.84e-04 0.40000 0.080200 3.92e-01 3.68e-01 1.10e-05
Resolution of Abasic Sites (AP sites) 38 2.32e-04 1.63e-03 0.40000 -0.377000 -1.33e-01 5.79e-05 1.54e-01
Pyrimidine catabolism 9 2.38e-01 3.68e-01 0.40000 0.264000 3.00e-01 1.70e-01 1.19e-01
Mitochondrial Uncoupling 6 3.75e-01 5.04e-01 0.39900 -0.317000 -2.43e-01 1.79e-01 3.03e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.28e-04 2.20e-03 0.39900 0.120000 3.81e-01 2.21e-01 9.61e-05
Interleukin-15 signaling 14 1.08e-01 2.16e-01 0.39900 0.266000 2.98e-01 8.49e-02 5.38e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.29e-03 1.14e-02 0.39900 0.386000 9.97e-02 8.35e-04 3.88e-01
Insulin processing 19 4.01e-02 1.06e-01 0.39800 0.222000 3.31e-01 9.43e-02 1.26e-02
Abacavir ADME 5 4.46e-01 5.64e-01 0.39800 0.313000 2.46e-01 2.26e-01 3.40e-01
Activated NTRK2 signals through RAS 6 3.81e-01 5.07e-01 0.39800 0.249000 3.11e-01 2.92e-01 1.88e-01
Activated NTRK3 signals through RAS 6 3.81e-01 5.07e-01 0.39800 0.249000 3.11e-01 2.92e-01 1.88e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 1.13e-01 2.21e-01 0.39600 -0.367000 1.50e-01 1.55e-01 5.62e-01
Maple Syrup Urine Disease 5 1.13e-01 2.21e-01 0.39600 -0.367000 1.50e-01 1.55e-01 5.62e-01
Signaling by the B Cell Receptor (BCR) 150 3.19e-13 9.42e-12 0.39600 0.169000 3.58e-01 3.66e-04 3.56e-14
Signaling by EGFR 47 8.80e-05 7.10e-04 0.39500 0.363000 1.57e-01 1.69e-05 6.25e-02
Creation of C4 and C2 activators 71 1.62e-06 2.08e-05 0.39500 0.175000 3.54e-01 1.09e-02 2.44e-07
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 1.95e-01 3.21e-01 0.39500 0.011800 -3.94e-01 9.64e-01 1.27e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 2.69e-05 2.56e-04 0.39400 0.057100 3.90e-01 5.37e-01 2.49e-05
p53-Independent DNA Damage Response 39 2.69e-05 2.56e-04 0.39400 0.057100 3.90e-01 5.37e-01 2.49e-05
p53-Independent G1/S DNA damage checkpoint 39 2.69e-05 2.56e-04 0.39400 0.057100 3.90e-01 5.37e-01 2.49e-05
ATF6 (ATF6-alpha) activates chaperone genes 10 2.10e-01 3.38e-01 0.39400 0.301000 2.55e-01 9.97e-02 1.63e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 1.59e-02 5.26e-02 0.39400 0.071100 3.88e-01 6.23e-01 7.26e-03
Activation of RAS in B cells 5 4.58e-01 5.74e-01 0.39300 0.250000 3.04e-01 3.34e-01 2.39e-01
Specification of primordial germ cells 6 5.74e-02 1.37e-01 0.39300 0.284000 -2.71e-01 2.28e-01 2.50e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.03e-01 3.30e-01 0.39100 0.362000 1.47e-01 7.63e-02 4.72e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.91e-01 3.19e-01 0.39000 0.277000 2.74e-01 1.11e-01 1.16e-01
Activation of G protein gated Potassium channels 18 6.54e-02 1.50e-01 0.39000 0.257000 2.92e-01 5.86e-02 3.17e-02
G protein gated Potassium channels 18 6.54e-02 1.50e-01 0.39000 0.257000 2.92e-01 5.86e-02 3.17e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 6.54e-02 1.50e-01 0.39000 0.257000 2.92e-01 5.86e-02 3.17e-02
Apoptotic cleavage of cellular proteins 35 1.08e-03 5.99e-03 0.39000 0.151000 3.59e-01 1.22e-01 2.37e-04
Zygotic genome activation (ZGA) 5 1.01e-01 2.05e-01 0.38900 0.223000 -3.19e-01 3.89e-01 2.16e-01
Interleukin-37 signaling 19 5.27e-02 1.28e-01 0.38900 0.308000 2.38e-01 2.01e-02 7.30e-02
Replacement of protamines by nucleosomes in the male pronucleus 12 1.60e-01 2.84e-01 0.38900 0.247000 3.01e-01 1.39e-01 7.14e-02
SUMOylation of transcription factors 16 9.12e-02 1.91e-01 0.38900 -0.276000 -2.74e-01 5.57e-02 5.80e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 4.64e-03 2.02e-02 0.38900 -0.361000 -1.44e-01 1.16e-03 1.95e-01
Inactivation of CDC42 and RAC1 7 2.33e-01 3.63e-01 0.38800 0.366000 1.29e-01 9.36e-02 5.55e-01
Cellular response to mitochondrial stress 9 1.55e-02 5.19e-02 0.38800 -0.255000 2.92e-01 1.86e-01 1.29e-01
Signaling by CSF3 (G-CSF) 29 4.73e-03 2.04e-02 0.38700 0.165000 3.51e-01 1.24e-01 1.08e-03
RUNX2 regulates genes involved in cell migration 6 2.55e-01 3.84e-01 0.38700 -0.099400 -3.74e-01 6.73e-01 1.13e-01
ATF6 (ATF6-alpha) activates chaperones 12 1.60e-01 2.84e-01 0.38700 0.239000 3.05e-01 1.52e-01 6.78e-02
PCNA-Dependent Long Patch Base Excision Repair 21 5.98e-03 2.42e-02 0.38700 -0.379000 -7.70e-02 2.64e-03 5.41e-01
LTC4-CYSLTR mediated IL4 production 5 1.57e-01 2.82e-01 0.38600 -0.082700 3.77e-01 7.49e-01 1.44e-01
Signaling by ALK 24 2.01e-02 6.33e-02 0.38600 0.327000 2.06e-01 5.61e-03 8.07e-02
Uptake and function of diphtheria toxin 6 3.33e-01 4.65e-01 0.38600 0.349000 1.64e-01 1.38e-01 4.86e-01
Recycling of bile acids and salts 8 2.41e-01 3.70e-01 0.38600 0.345000 1.74e-01 9.15e-02 3.94e-01
Synthesis of 5-eicosatetraenoic acids 7 2.26e-01 3.55e-01 0.38500 -0.116000 -3.67e-01 5.96e-01 9.28e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 7.78e-03 3.02e-02 0.38500 -0.384000 -1.97e-02 6.11e-03 8.88e-01
Signal regulatory protein family interactions 13 1.48e-01 2.69e-01 0.38400 0.256000 2.86e-01 1.10e-01 7.38e-02
Beta-catenin phosphorylation cascade 17 7.44e-02 1.65e-01 0.38400 0.227000 3.09e-01 1.05e-01 2.72e-02
Regulation of innate immune responses to cytosolic DNA 14 4.71e-02 1.18e-01 0.38300 -0.368000 -1.05e-01 1.70e-02 4.98e-01
Inwardly rectifying K+ channels 22 3.38e-02 9.34e-02 0.38300 0.313000 2.21e-01 1.11e-02 7.32e-02
Somitogenesis 41 3.60e-04 2.39e-03 0.38300 0.141000 3.56e-01 1.19e-01 8.00e-05
Signaling by SCF-KIT 40 3.09e-03 1.44e-02 0.38200 0.276000 2.65e-01 2.56e-03 3.77e-03
PKA activation 15 7.23e-02 1.61e-01 0.38200 0.342000 1.70e-01 2.19e-02 2.53e-01
p38MAPK events 13 1.54e-01 2.77e-01 0.38100 0.275000 2.64e-01 8.66e-02 9.87e-02
N-glycan trimming and elongation in the cis-Golgi 5 1.28e-01 2.43e-01 0.38100 -0.157000 3.47e-01 5.43e-01 1.79e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 2.17e-05 2.13e-04 0.38100 0.042400 3.79e-01 6.38e-01 2.73e-05
Translesion synthesis by POLK 17 3.11e-03 1.45e-02 0.38100 -0.376000 5.60e-02 7.21e-03 6.89e-01
Alpha-oxidation of phytanate 6 2.41e-01 3.70e-01 0.38000 -0.373000 -7.40e-02 1.13e-01 7.53e-01
Translesion Synthesis by POLH 18 3.89e-03 1.76e-02 0.38000 -0.380000 1.74e-02 5.30e-03 8.98e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 9.33e-05 7.47e-04 0.38000 0.054600 3.76e-01 5.66e-01 7.61e-05
Fc epsilon receptor (FCERI) signaling 179 5.04e-14 1.64e-12 0.38000 0.171000 3.39e-01 8.05e-05 5.08e-15
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 2.76e-03 1.33e-02 0.37900 -0.372000 -7.39e-02 1.28e-03 5.22e-01
Smooth Muscle Contraction 34 7.93e-03 3.07e-02 0.37900 0.270000 2.66e-01 6.43e-03 7.18e-03
Interleukin-4 and Interleukin-13 signaling 89 4.57e-08 7.84e-07 0.37900 0.353000 1.39e-01 8.57e-09 2.35e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 4.79e-03 2.06e-02 0.37900 -0.353000 -1.37e-01 1.22e-03 2.09e-01
NFE2L2 regulating ER-stress associated genes 5 1.09e-01 2.17e-01 0.37900 0.271000 -2.65e-01 2.95e-01 3.05e-01
Vitamin C (ascorbate) metabolism 8 1.61e-01 2.84e-01 0.37800 0.369000 8.15e-02 7.04e-02 6.90e-01
PDH complex synthesizes acetyl-CoA from PYR 5 1.30e-01 2.46e-01 0.37700 -0.167000 3.38e-01 5.18e-01 1.90e-01
Heme degradation 10 3.06e-02 8.68e-02 0.37600 0.368000 -7.79e-02 4.39e-02 6.70e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 7.46e-02 1.65e-01 0.37600 0.182000 3.29e-01 2.06e-01 2.29e-02
COPI-dependent Golgi-to-ER retrograde traffic 90 2.48e-06 3.07e-05 0.37600 0.232000 2.95e-01 1.43e-04 1.26e-06
Degradation of GLI2 by the proteasome 45 3.47e-05 3.21e-04 0.37500 0.076200 3.67e-01 3.76e-01 1.99e-05
GLI3 is processed to GLI3R by the proteasome 45 3.47e-05 3.21e-04 0.37500 0.076200 3.67e-01 3.76e-01 1.99e-05
RNA Polymerase I Promoter Opening 17 7.76e-02 1.69e-01 0.37500 0.209000 3.12e-01 1.36e-01 2.61e-02
Vif-mediated degradation of APOBEC3G 41 1.18e-05 1.24e-04 0.37500 0.012400 3.75e-01 8.91e-01 3.28e-05
Signaling by cytosolic FGFR1 fusion mutants 18 7.00e-02 1.57e-01 0.37500 0.216000 3.07e-01 1.13e-01 2.43e-02
tRNA processing in the nucleus 59 1.95e-05 1.95e-04 0.37500 -0.348000 -1.40e-01 3.86e-06 6.21e-02
Repression of WNT target genes 14 1.08e-01 2.16e-01 0.37500 0.325000 1.87e-01 3.55e-02 2.25e-01
Activation of Matrix Metalloproteinases 20 2.18e-03 1.10e-02 0.37500 0.374000 -2.55e-02 3.79e-03 8.43e-01
G beta:gamma signalling through CDC42 17 4.69e-02 1.18e-01 0.37400 0.146000 3.45e-01 2.98e-01 1.39e-02
Malate-aspartate shuttle 8 1.05e-01 2.13e-01 0.37400 -0.374000 -5.40e-03 6.69e-02 9.79e-01
Interleukin-7 signaling 21 3.18e-02 8.98e-02 0.37400 0.331000 1.73e-01 8.64e-03 1.70e-01
Hedgehog ligand biogenesis 47 3.84e-05 3.46e-04 0.37300 0.088200 3.62e-01 2.95e-01 1.71e-05
Vpr-mediated nuclear import of PICs 34 5.61e-03 2.30e-02 0.37300 -0.317000 -1.97e-01 1.40e-03 4.64e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 3.11e-01 4.46e-01 0.37300 0.167000 3.33e-01 4.45e-01 1.27e-01
Pexophagy 10 8.09e-02 1.75e-01 0.37300 -0.370000 -4.09e-02 4.25e-02 8.23e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 74 3.96e-06 4.73e-05 0.37200 0.335000 1.63e-01 6.20e-07 1.55e-02
Estrogen biosynthesis 5 4.02e-01 5.26e-01 0.37200 0.345000 1.38e-01 1.81e-01 5.93e-01
APC truncation mutants have impaired AXIN binding 14 1.07e-01 2.14e-01 0.37200 0.178000 3.26e-01 2.49e-01 3.44e-02
AXIN missense mutants destabilize the destruction complex 14 1.07e-01 2.14e-01 0.37200 0.178000 3.26e-01 2.49e-01 3.44e-02
Signaling by AMER1 mutants 14 1.07e-01 2.14e-01 0.37200 0.178000 3.26e-01 2.49e-01 3.44e-02
Signaling by APC mutants 14 1.07e-01 2.14e-01 0.37200 0.178000 3.26e-01 2.49e-01 3.44e-02
Signaling by AXIN mutants 14 1.07e-01 2.14e-01 0.37200 0.178000 3.26e-01 2.49e-01 3.44e-02
Truncations of AMER1 destabilize the destruction complex 14 1.07e-01 2.14e-01 0.37200 0.178000 3.26e-01 2.49e-01 3.44e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 59 7.67e-05 6.30e-04 0.37200 0.176000 3.28e-01 1.95e-02 1.35e-05
FLT3 signaling in disease 27 2.49e-02 7.35e-02 0.37200 0.267000 2.59e-01 1.64e-02 1.99e-02
Gap junction trafficking 27 1.71e-02 5.55e-02 0.37100 0.315000 1.97e-01 4.67e-03 7.60e-02
Regulation of signaling by CBL 22 4.03e-02 1.06e-01 0.37000 0.207000 3.07e-01 9.27e-02 1.27e-02
Hh mutants abrogate ligand secretion 43 5.56e-05 4.68e-04 0.37000 0.066900 3.64e-01 4.48e-01 3.64e-05
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 6.65e-02 1.52e-01 0.36900 0.248000 2.73e-01 5.47e-02 3.43e-02
Regulation of Apoptosis 40 4.85e-05 4.23e-04 0.36900 0.037800 3.67e-01 6.79e-01 5.87e-05
mRNA Editing 8 3.24e-01 4.57e-01 0.36900 0.296000 2.20e-01 1.47e-01 2.82e-01
Protein methylation 15 4.70e-02 1.18e-01 0.36900 -0.355000 -9.82e-02 1.72e-02 5.10e-01
Miscellaneous substrates 7 5.67e-02 1.36e-01 0.36800 0.303000 -2.09e-01 1.65e-01 3.38e-01
p75NTR negatively regulates cell cycle via SC1 5 3.98e-01 5.21e-01 0.36800 0.127000 3.46e-01 6.22e-01 1.81e-01
Tie2 Signaling 16 9.45e-02 1.95e-01 0.36800 0.198000 3.11e-01 1.71e-01 3.15e-02
Metabolism of non-coding RNA 53 1.39e-04 1.06e-03 0.36800 -0.334000 -1.55e-01 2.58e-05 5.15e-02
snRNP Assembly 53 1.39e-04 1.06e-03 0.36800 -0.334000 -1.55e-01 2.58e-05 5.15e-02
Long-term potentiation 14 1.53e-01 2.77e-01 0.36800 -0.257000 -2.63e-01 9.59e-02 8.82e-02
Maturation of spike protein 9694548 35 6.52e-03 2.62e-02 0.36800 0.206000 3.04e-01 3.49e-02 1.82e-03
Regulation of RAS by GAPs 55 2.46e-05 2.38e-04 0.36700 0.112000 3.50e-01 1.52e-01 7.07e-06
Signalling to RAS 19 7.61e-02 1.67e-01 0.36700 0.281000 2.37e-01 3.39e-02 7.43e-02
Negative regulation of NOTCH4 signaling 44 2.90e-05 2.74e-04 0.36700 0.048800 3.64e-01 5.75e-01 2.94e-05
cGMP effects 12 2.30e-02 6.91e-02 0.36700 0.051600 -3.64e-01 7.57e-01 2.92e-02
Telomere C-strand (Lagging Strand) Synthesis 34 1.87e-04 1.35e-03 0.36700 -0.366000 -2.88e-02 2.21e-04 7.71e-01
Phase 3 - rapid repolarisation 7 2.16e-01 3.42e-01 0.36600 0.072800 3.59e-01 7.39e-01 9.99e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 4.51e-01 5.66e-01 0.36600 0.256000 2.62e-01 2.77e-01 2.67e-01
Cation-coupled Chloride cotransporters 6 1.56e-01 2.80e-01 0.36600 0.363000 -4.71e-02 1.23e-01 8.42e-01
STAT5 Activation 7 2.30e-01 3.59e-01 0.36600 0.356000 8.45e-02 1.03e-01 6.98e-01
Nef and signal transduction 8 2.45e-01 3.72e-01 0.36600 0.136000 3.40e-01 5.05e-01 9.63e-02
Alternative complement activation 5 3.16e-01 4.50e-01 0.36600 -0.362000 -5.60e-02 1.62e-01 8.28e-01
PECAM1 interactions 12 1.59e-01 2.84e-01 0.36600 0.179000 3.19e-01 2.83e-01 5.57e-02
BBSome-mediated cargo-targeting to cilium 23 3.13e-04 2.13e-03 0.36600 -0.350000 1.07e-01 3.69e-03 3.76e-01
RHOC GTPase cycle 71 5.35e-05 4.53e-04 0.36500 0.296000 2.13e-01 1.61e-05 1.89e-03
Erythropoietin activates Phospholipase C gamma (PLCG) 6 4.05e-01 5.28e-01 0.36400 0.316000 1.81e-01 1.80e-01 4.44e-01
Cell surface interactions at the vascular wall 170 4.62e-11 1.11e-09 0.36400 0.205000 3.01e-01 3.95e-06 1.27e-11
Free fatty acids regulate insulin secretion 10 5.99e-02 1.41e-01 0.36400 0.364000 -1.48e-02 4.64e-02 9.35e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 6.49e-05 5.37e-04 0.36400 0.052700 3.60e-01 5.55e-01 5.46e-05
Other semaphorin interactions 16 6.00e-02 1.41e-01 0.36300 0.339000 1.31e-01 1.90e-02 3.63e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.65e-05 1.71e-04 0.36300 0.076400 3.55e-01 3.40e-01 9.42e-06
Class I peroxisomal membrane protein import 20 1.52e-03 8.20e-03 0.36200 -0.354000 7.61e-02 6.09e-03 5.56e-01
Uptake of dietary cobalamins into enterocytes 5 4.25e-01 5.47e-01 0.36200 0.137000 3.35e-01 5.96e-01 1.94e-01
Transport of nucleotide sugars 9 3.05e-01 4.40e-01 0.36200 -0.277000 -2.33e-01 1.50e-01 2.26e-01
MAPK6/MAPK4 signaling 69 5.16e-06 5.97e-05 0.36100 0.126000 3.39e-01 7.06e-02 1.13e-06
mRNA Splicing - Minor Pathway 50 1.97e-05 1.96e-04 0.36100 -0.355000 -6.61e-02 1.38e-05 4.19e-01
Constitutive Signaling by EGFRvIII 14 1.65e-01 2.87e-01 0.36100 0.253000 2.57e-01 1.02e-01 9.54e-02
Signaling by EGFRvIII in Cancer 14 1.65e-01 2.87e-01 0.36100 0.253000 2.57e-01 1.02e-01 9.54e-02
Sema3A PAK dependent Axon repulsion 15 1.45e-01 2.65e-01 0.36000 0.249000 2.61e-01 9.53e-02 8.04e-02
ADORA2B mediated anti-inflammatory cytokines production 35 1.04e-02 3.85e-02 0.35900 0.227000 2.79e-01 2.02e-02 4.32e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 2.02e-01 3.30e-01 0.35900 0.215000 2.88e-01 1.97e-01 8.43e-02
HDMs demethylate histones 22 9.88e-03 3.73e-02 0.35900 0.352000 7.20e-02 4.27e-03 5.59e-01
Polymerase switching on the C-strand of the telomere 26 2.96e-03 1.39e-02 0.35900 -0.355000 -5.21e-02 1.71e-03 6.46e-01
Signal amplification 28 2.66e-02 7.74e-02 0.35900 0.275000 2.30e-01 1.17e-02 3.49e-02
Ubiquinol biosynthesis 13 1.15e-01 2.24e-01 0.35900 -0.331000 -1.38e-01 3.87e-02 3.90e-01
Transcriptional Regulation by NPAS4 27 2.07e-02 6.39e-02 0.35900 0.308000 1.83e-01 5.55e-03 9.94e-02
Signaling by FGFR4 in disease 11 2.41e-01 3.70e-01 0.35900 0.275000 2.30e-01 1.15e-01 1.86e-01
Gap junction trafficking and regulation 29 1.85e-02 5.90e-02 0.35800 0.299000 1.98e-01 5.37e-03 6.50e-02
Constitutive Signaling by Overexpressed ERBB2 11 2.41e-01 3.70e-01 0.35800 0.227000 2.77e-01 1.92e-01 1.12e-01
Mucopolysaccharidoses 11 1.60e-01 2.84e-01 0.35800 -0.136000 -3.31e-01 4.34e-01 5.74e-02
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 2.16e-01 3.42e-01 0.35800 0.352000 -6.16e-02 1.72e-01 8.11e-01
Acyl chain remodelling of PG 11 2.43e-01 3.71e-01 0.35700 0.275000 2.27e-01 1.14e-01 1.92e-01
Lagging Strand Synthesis 20 1.42e-02 4.88e-02 0.35700 -0.351000 -6.36e-02 6.57e-03 6.22e-01
ABC transporter disorders 59 4.54e-05 4.04e-04 0.35600 0.127000 3.33e-01 9.04e-02 9.85e-06
Post-translational protein phosphorylation 67 5.08e-05 4.37e-04 0.35600 0.314000 1.67e-01 8.73e-06 1.83e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.00e-03 5.71e-03 0.35400 0.268000 2.32e-01 5.82e-04 2.94e-03
Synthesis of PE 12 2.14e-01 3.41e-01 0.35400 -0.214000 -2.82e-01 1.99e-01 9.13e-02
Intrinsic Pathway of Fibrin Clot Formation 15 1.35e-01 2.54e-01 0.35400 0.197000 2.93e-01 1.86e-01 4.92e-02
CDC6 association with the ORC:origin complex 8 9.71e-02 1.99e-01 0.35300 -0.051500 3.49e-01 8.01e-01 8.74e-02
Apoptotic execution phase 46 3.21e-04 2.17e-03 0.35300 0.112000 3.34e-01 1.91e-01 8.68e-05
Nucleotide biosynthesis 12 1.23e-01 2.37e-01 0.35200 -0.334000 -1.12e-01 4.50e-02 5.01e-01
Transport to the Golgi and subsequent modification 170 1.08e-10 2.49e-09 0.35200 0.187000 2.98e-01 2.47e-05 1.86e-11
Ubiquitin-dependent degradation of Cyclin D 39 1.72e-04 1.27e-03 0.35200 0.041500 3.50e-01 6.53e-01 1.57e-04
Activation of C3 and C5 7 2.38e-01 3.68e-01 0.35200 -0.066000 -3.46e-01 7.62e-01 1.13e-01
Degradation of GLI1 by the proteasome 46 1.23e-04 9.52e-04 0.35200 0.078400 3.43e-01 3.58e-01 5.69e-05
Formation of apoptosome 11 1.82e-02 5.84e-02 0.35200 -0.175000 3.05e-01 3.16e-01 7.96e-02
Regulation of the apoptosome activity 11 1.82e-02 5.84e-02 0.35200 -0.175000 3.05e-01 3.16e-01 7.96e-02
Nuclear events mediated by NFE2L2 81 5.23e-05 4.44e-04 0.35100 0.241000 2.55e-01 1.73e-04 7.39e-05
KSRP (KHSRP) binds and destabilizes mRNA 17 1.16e-02 4.21e-02 0.35100 -0.350000 1.60e-02 1.24e-02 9.09e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 1.89e-05 1.90e-04 0.35000 0.136000 3.23e-01 5.00e-02 3.52e-06
Complex I biogenesis 66 3.23e-07 4.70e-06 0.35000 -0.349000 -3.18e-02 9.51e-07 6.55e-01
Leishmania infection 210 5.70e-12 1.52e-10 0.35000 0.220000 2.73e-01 4.13e-08 9.39e-12
Parasitic Infection Pathways 210 5.70e-12 1.52e-10 0.35000 0.220000 2.73e-01 4.13e-08 9.39e-12
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 2.02e-01 3.30e-01 0.34900 0.348000 -2.46e-02 1.39e-01 9.17e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 2.02e-01 3.30e-01 0.34900 0.348000 -2.46e-02 1.39e-01 9.17e-01
Glutathione synthesis and recycling 10 2.68e-01 3.96e-01 0.34900 0.190000 2.93e-01 2.98e-01 1.09e-01
Reversible hydration of carbon dioxide 8 5.37e-02 1.30e-01 0.34900 0.191000 -2.92e-01 3.49e-01 1.53e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.10e-01 4.45e-01 0.34900 -0.074100 -3.41e-01 7.53e-01 1.48e-01
RNA Polymerase III Transcription Termination 22 2.94e-02 8.41e-02 0.34900 -0.324000 -1.29e-01 8.52e-03 2.96e-01
Platelet homeostasis 69 2.48e-04 1.72e-03 0.34900 0.256000 2.36e-01 2.34e-04 6.86e-04
TICAM1, RIP1-mediated IKK complex recruitment 19 5.73e-02 1.37e-01 0.34800 0.145000 3.16e-01 2.75e-01 1.70e-02
Nucleotide-like (purinergic) receptors 14 1.47e-01 2.68e-01 0.34700 0.171000 3.02e-01 2.67e-01 5.06e-02
RHOBTB2 GTPase cycle 23 1.62e-02 5.34e-02 0.34700 0.093800 3.34e-01 4.36e-01 5.61e-03
SCF-beta-TrCP mediated degradation of Emi1 42 1.43e-04 1.07e-03 0.34600 0.046800 3.43e-01 6.00e-01 1.18e-04
Biosynthesis of E-series 18(S)-resolvins 5 3.38e-01 4.70e-01 0.34600 0.344000 3.78e-02 1.83e-01 8.84e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.32e-06 1.75e-05 0.34600 0.044800 3.43e-01 5.35e-01 2.05e-06
Defective binding of VWF variant to GPIb:IX:V 5 4.47e-01 5.64e-01 0.34500 0.323000 1.21e-01 2.11e-01 6.39e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 4.47e-01 5.64e-01 0.34500 0.323000 1.21e-01 2.11e-01 6.39e-01
Degradation of beta-catenin by the destruction complex 72 1.57e-05 1.63e-04 0.34500 0.133000 3.18e-01 5.11e-02 2.96e-06
COPI-mediated anterograde transport 92 5.28e-06 6.04e-05 0.34500 0.177000 2.96e-01 3.26e-03 9.31e-07
Autodegradation of the E3 ubiquitin ligase COP1 38 1.94e-04 1.40e-03 0.34500 0.023900 3.44e-01 7.99e-01 2.44e-04
SARS-CoV-2 modulates autophagy 11 2.55e-01 3.84e-01 0.34500 -0.281000 -2.00e-01 1.07e-01 2.51e-01
Adenylate cyclase activating pathway 8 5.49e-02 1.32e-01 0.34400 0.216000 -2.68e-01 2.89e-01 1.90e-01
Biosynthesis of EPA-derived SPMs 6 2.11e-01 3.39e-01 0.34300 0.342000 -2.69e-02 1.47e-01 9.09e-01
P2Y receptors 10 2.39e-01 3.69e-01 0.34200 0.148000 3.09e-01 4.19e-01 9.09e-02
IkBA variant leads to EDA-ID 7 9.22e-02 1.92e-01 0.34200 0.161000 -3.02e-01 4.61e-01 1.67e-01
Pre-NOTCH Processing in Golgi 18 1.09e-01 2.17e-01 0.34200 0.281000 1.95e-01 3.93e-02 1.51e-01
RHOBTB GTPase Cycle 35 5.81e-03 2.36e-02 0.34200 0.139000 3.12e-01 1.56e-01 1.38e-03
ER to Golgi Anterograde Transport 145 9.73e-09 1.80e-07 0.34100 0.180000 2.90e-01 1.80e-04 1.66e-09
SCF(Skp2)-mediated degradation of p27/p21 50 2.07e-04 1.46e-03 0.34100 0.098500 3.27e-01 2.28e-01 6.40e-05
Respiratory electron transport 149 6.61e-14 2.08e-12 0.34100 -0.338000 -4.60e-02 1.03e-12 3.32e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.68e-06 2.14e-05 0.34100 0.036100 3.39e-01 6.20e-01 3.22e-06
Collagen degradation 41 8.32e-04 4.83e-03 0.34100 0.328000 9.21e-02 2.80e-04 3.08e-01
Laminin interactions 25 1.24e-02 4.41e-02 0.34000 0.329000 8.70e-02 4.44e-03 4.52e-01
Orc1 removal from chromatin 58 2.51e-06 3.09e-05 0.34000 0.018000 3.39e-01 8.12e-01 7.76e-06
NOTCH2 intracellular domain regulates transcription 11 2.88e-02 8.28e-02 0.34000 0.313000 -1.33e-01 7.27e-02 4.46e-01
HS-GAG degradation 18 7.74e-02 1.69e-01 0.33900 -0.144000 -3.07e-01 2.91e-01 2.39e-02
IRAK4 deficiency (TLR2/4) 15 1.12e-01 2.21e-01 0.33900 0.137000 3.11e-01 3.60e-01 3.73e-02
MyD88 deficiency (TLR2/4) 14 1.54e-01 2.77e-01 0.33900 0.161000 2.99e-01 2.98e-01 5.30e-02
Factors involved in megakaryocyte development and platelet production 128 2.25e-07 3.41e-06 0.33900 0.276000 1.97e-01 7.10e-08 1.19e-04
tRNA processing 128 3.85e-08 6.67e-07 0.33800 -0.299000 -1.59e-01 5.15e-09 1.93e-03
Maturation of TCA enzymes and regulation of TCA cycle 20 9.33e-03 3.55e-02 0.33800 -0.338000 2.04e-03 8.96e-03 9.87e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.93e-01 3.20e-01 0.33800 0.289000 1.75e-01 7.15e-02 2.75e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 2.36e-01 3.67e-01 0.33700 -0.190000 -2.78e-01 2.54e-01 9.57e-02
Interleukin-2 family signaling 38 1.38e-02 4.76e-02 0.33600 0.223000 2.52e-01 1.74e-02 7.20e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.59e-01 3.87e-01 0.33600 0.249000 2.26e-01 1.35e-01 1.75e-01
alpha-linolenic acid (ALA) metabolism 12 2.59e-01 3.87e-01 0.33600 0.249000 2.26e-01 1.35e-01 1.75e-01
Neutrophil degranulation 456 1.56e-22 9.97e-21 0.33600 0.229000 2.46e-01 4.36e-17 2.21e-19
RHO GTPases activate PKNs 46 4.62e-03 2.01e-02 0.33600 0.200000 2.70e-01 1.89e-02 1.52e-03
L1CAM interactions 100 3.25e-06 3.95e-05 0.33600 0.290000 1.70e-01 5.46e-07 3.30e-03
Vpu mediated degradation of CD4 39 1.31e-04 1.00e-03 0.33600 0.000863 3.36e-01 9.93e-01 2.83e-04
Inactivation of CSF3 (G-CSF) signaling 24 1.75e-02 5.65e-02 0.33600 0.090100 3.23e-01 4.45e-01 6.09e-03
Nuclear events stimulated by ALK signaling in cancer 33 1.55e-02 5.19e-02 0.33500 0.170000 2.89e-01 9.09e-02 4.04e-03
Termination of translesion DNA synthesis 32 2.62e-04 1.80e-03 0.33500 -0.333000 4.08e-02 1.12e-03 6.90e-01
Mitochondrial unfolded protein response (UPRmt) 17 5.75e-02 1.37e-01 0.33500 -0.090400 -3.23e-01 5.19e-01 2.11e-02
Pentose phosphate pathway 13 1.75e-01 3.01e-01 0.33500 0.151000 2.99e-01 3.45e-01 6.18e-02
VEGFA-VEGFR2 Pathway 93 3.42e-05 3.19e-04 0.33500 0.241000 2.32e-01 5.76e-05 1.11e-04
Condensation of Prophase Chromosomes 27 3.33e-02 9.26e-02 0.33400 0.168000 2.89e-01 1.31e-01 9.29e-03
Killing mechanisms 9 9.97e-02 2.03e-01 0.33400 0.040500 -3.32e-01 8.33e-01 8.47e-02
WNT5:FZD7-mediated leishmania damping 9 9.97e-02 2.03e-01 0.33400 0.040500 -3.32e-01 8.33e-01 8.47e-02
Depolymerization of the Nuclear Lamina 15 1.79e-01 3.05e-01 0.33400 0.265000 2.03e-01 7.52e-02 1.73e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 2.08e-01 3.35e-01 0.33400 -0.216000 -2.55e-01 1.62e-01 9.85e-02
SUMOylation of ubiquitinylation proteins 39 1.19e-02 4.31e-02 0.33400 -0.263000 -2.06e-01 4.48e-03 2.64e-02
tRNA modification in the nucleus and cytosol 43 2.91e-03 1.38e-02 0.33200 -0.301000 -1.41e-01 6.43e-04 1.09e-01
Modulation by Mtb of host immune system 7 1.76e-01 3.02e-01 0.33200 -0.331000 3.28e-02 1.30e-01 8.80e-01
RHOBTB1 GTPase cycle 23 2.78e-02 8.01e-02 0.33200 0.104000 3.15e-01 3.89e-01 8.88e-03
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.20e-02 4.33e-02 0.33100 -0.324000 -6.77e-02 5.09e-03 5.58e-01
RHO GTPase Effectors 257 7.60e-14 2.32e-12 0.33100 0.178000 2.79e-01 8.96e-07 1.45e-14
Transport of Ribonucleoproteins into the Host Nucleus 32 1.94e-02 6.13e-02 0.33000 -0.286000 -1.65e-01 5.09e-03 1.06e-01
NPAS4 regulates expression of target genes 16 2.01e-02 6.33e-02 0.33000 0.328000 -3.27e-02 2.31e-02 8.21e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 1.09e-01 2.17e-01 0.32900 -0.036100 3.27e-01 8.51e-01 8.90e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 4.22e-03 1.88e-02 0.32900 0.255000 2.09e-01 1.83e-03 1.07e-02
PI3K events in ERBB4 signaling 6 1.60e-01 2.84e-01 0.32900 0.300000 -1.34e-01 2.03e-01 5.69e-01
Late SARS-CoV-2 Infection Events 63 4.64e-04 2.90e-03 0.32900 0.164000 2.85e-01 2.40e-02 9.33e-05
PI-3K cascade:FGFR3 10 3.31e-01 4.64e-01 0.32800 0.261000 2.00e-01 1.54e-01 2.74e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.81e-01 3.06e-01 0.32700 0.182000 2.71e-01 2.22e-01 6.91e-02
CTNNB1 S37 mutants aren’t phosphorylated 15 1.81e-01 3.06e-01 0.32700 0.182000 2.71e-01 2.22e-01 6.91e-02
CTNNB1 S45 mutants aren’t phosphorylated 15 1.81e-01 3.06e-01 0.32700 0.182000 2.71e-01 2.22e-01 6.91e-02
CTNNB1 T41 mutants aren’t phosphorylated 15 1.81e-01 3.06e-01 0.32700 0.182000 2.71e-01 2.22e-01 6.91e-02
Signaling by CTNNB1 phospho-site mutants 15 1.81e-01 3.06e-01 0.32700 0.182000 2.71e-01 2.22e-01 6.91e-02
Signaling by GSK3beta mutants 15 1.81e-01 3.06e-01 0.32700 0.182000 2.71e-01 2.22e-01 6.91e-02
Retinoid metabolism and transport 23 8.47e-03 3.26e-02 0.32700 0.326000 1.46e-02 6.76e-03 9.04e-01
Initial triggering of complement 79 3.84e-05 3.46e-04 0.32700 0.143000 2.93e-01 2.75e-02 6.55e-06
Response to elevated platelet cytosolic Ca2+ 108 9.66e-06 1.05e-04 0.32600 0.207000 2.52e-01 1.97e-04 6.14e-06
GPVI-mediated activation cascade 31 3.76e-02 1.01e-01 0.32600 0.218000 2.43e-01 3.57e-02 1.94e-02
COPII-mediated vesicle transport 67 3.75e-04 2.46e-03 0.32600 0.168000 2.79e-01 1.75e-02 7.74e-05
Phase 2 - plateau phase 12 2.63e-01 3.91e-01 0.32600 0.188000 2.66e-01 2.60e-01 1.11e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 3.00e-04 2.05e-03 0.32600 0.033600 3.24e-01 7.07e-01 2.82e-04
Mitochondrial Fatty Acid Beta-Oxidation 36 4.86e-04 3.00e-03 0.32500 -0.325000 -5.11e-03 7.35e-04 9.58e-01
Activation of RAC1 11 1.58e-01 2.83e-01 0.32500 0.071400 3.17e-01 6.82e-01 6.88e-02
Recycling of eIF2:GDP 8 1.48e-01 2.69e-01 0.32400 -0.322000 3.62e-02 1.15e-01 8.59e-01
Insulin receptor recycling 24 6.14e-02 1.44e-01 0.32400 0.277000 1.68e-01 1.88e-02 1.54e-01
Hydrolysis of LPC 8 1.54e-01 2.77e-01 0.32300 0.321000 -3.14e-02 1.15e-01 8.78e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.72e-02 5.58e-02 0.32300 0.298000 -1.24e-01 5.34e-02 4.22e-01
Mitochondrial protein degradation 96 4.79e-09 9.20e-08 0.32300 -0.322000 -1.82e-02 4.79e-08 7.58e-01
Phase 0 - rapid depolarisation 23 6.26e-02 1.45e-01 0.32300 0.283000 1.54e-01 1.86e-02 2.01e-01
HDL remodeling 6 1.51e-01 2.74e-01 0.32200 0.263000 -1.86e-01 2.64e-01 4.29e-01
NS1 Mediated Effects on Host Pathways 40 3.39e-03 1.56e-02 0.32200 -0.303000 -1.09e-01 9.03e-04 2.33e-01
Proteasome assembly 50 2.03e-06 2.55e-05 0.32200 -0.078100 3.12e-01 3.40e-01 1.33e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 3.42e-02 9.40e-02 0.32200 -0.110000 3.02e-01 5.08e-01 6.97e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 1.90e-03 9.85e-03 0.32200 -0.008000 3.21e-01 9.41e-01 2.73e-03
Chemokine receptors bind chemokines 39 1.20e-04 9.32e-04 0.32100 0.320000 -3.16e-02 5.48e-04 7.33e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 5.49e-01 6.53e-01 0.32100 0.153000 2.83e-01 5.55e-01 2.74e-01
Degradation of DVL 43 7.47e-04 4.37e-03 0.32100 0.064600 3.15e-01 4.64e-01 3.58e-04
Regulation of Complement cascade 96 3.81e-05 3.46e-04 0.32100 0.192000 2.57e-01 1.14e-03 1.34e-05
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 6.43e-06 7.31e-05 0.32100 0.020300 3.20e-01 7.84e-01 1.51e-05
Mitochondrial iron-sulfur cluster biogenesis 13 8.67e-02 1.85e-01 0.32100 -0.319000 -3.24e-02 4.63e-02 8.40e-01
Plasma lipoprotein assembly 10 1.36e-01 2.54e-01 0.32000 0.320000 1.45e-02 7.96e-02 9.37e-01
Scavenging by Class A Receptors 10 1.28e-01 2.43e-01 0.32000 0.320000 5.84e-03 7.94e-02 9.75e-01
ROS and RNS production in phagocytes 30 4.82e-02 1.20e-01 0.32000 0.227000 2.25e-01 3.12e-02 3.30e-02
Transport of the SLBP Dependant Mature mRNA 36 2.31e-02 6.92e-02 0.31900 -0.255000 -1.91e-01 8.09e-03 4.72e-02
MET activates RAS signaling 10 3.63e-01 4.95e-01 0.31900 0.238000 2.12e-01 1.93e-01 2.46e-01
Assembly of the ORC complex at the origin of replication 23 1.43e-02 4.88e-02 0.31800 0.032600 3.17e-01 7.87e-01 8.58e-03
Detoxification of Reactive Oxygen Species 30 3.43e-02 9.40e-02 0.31800 0.164000 2.73e-01 1.20e-01 9.76e-03
CD28 dependent Vav1 pathway 12 9.53e-02 1.96e-01 0.31800 0.014800 3.17e-01 9.29e-01 5.70e-02
Ca2+ pathway 57 3.39e-03 1.56e-02 0.31800 0.229000 2.20e-01 2.74e-03 4.11e-03
Interleukin-35 Signalling 12 2.54e-01 3.83e-01 0.31800 0.158000 2.75e-01 3.42e-01 9.89e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 5.66e-02 1.36e-01 0.31700 -0.070200 -3.09e-01 6.06e-01 2.31e-02
Signaling by ALK fusions and activated point mutants 89 1.40e-04 1.06e-03 0.31700 0.213000 2.35e-01 5.25e-04 1.25e-04
Signaling by ALK in cancer 89 1.40e-04 1.06e-03 0.31700 0.213000 2.35e-01 5.25e-04 1.25e-04
PINK1-PRKN Mediated Mitophagy 31 8.05e-05 6.55e-04 0.31700 -0.260000 1.82e-01 1.24e-02 7.92e-02
Platelet degranulation 104 2.85e-05 2.70e-04 0.31600 0.201000 2.44e-01 3.85e-04 1.70e-05
AMPK inhibits chREBP transcriptional activation activity 6 5.52e-01 6.55e-01 0.31600 -0.228000 -2.20e-01 3.34e-01 3.52e-01
Cellular response to hypoxia 59 3.23e-04 2.18e-03 0.31600 0.108000 2.97e-01 1.51e-01 7.87e-05
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.48e-02 9.51e-02 0.31600 0.228000 2.19e-01 2.14e-02 2.74e-02
Interleukin-2 signaling 11 3.32e-01 4.65e-01 0.31600 0.204000 2.41e-01 2.41e-01 1.66e-01
Acyl chain remodelling of PC 19 1.48e-01 2.69e-01 0.31500 0.245000 1.99e-01 6.44e-02 1.34e-01
Activation of gene expression by SREBF (SREBP) 42 1.05e-02 3.87e-02 0.31500 0.267000 1.67e-01 2.75e-03 6.07e-02
RNA Polymerase I Transcription Termination 30 2.71e-02 7.84e-02 0.31500 -0.283000 -1.38e-01 7.26e-03 1.90e-01
G-protein activation 19 1.54e-01 2.78e-01 0.31400 0.234000 2.10e-01 7.77e-02 1.13e-01
PKA activation in glucagon signalling 14 2.28e-01 3.58e-01 0.31400 0.261000 1.75e-01 9.09e-02 2.56e-01
Translation of Structural Proteins 9694635 55 1.03e-03 5.84e-03 0.31400 0.126000 2.88e-01 1.06e-01 2.22e-04
Digestion and absorption 7 3.53e-01 4.88e-01 0.31400 0.303000 8.24e-02 1.65e-01 7.06e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 7.68e-06 8.64e-05 0.31400 0.006580 3.14e-01 9.30e-01 2.60e-05
Endosomal/Vacuolar pathway 11 1.23e-01 2.38e-01 0.31400 -0.313000 -1.64e-02 7.18e-02 9.25e-01
Attenuation phase 22 6.99e-02 1.57e-01 0.31400 0.284000 1.34e-01 2.12e-02 2.78e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 1.38e-01 2.57e-01 0.31400 0.281000 -1.39e-01 1.98e-01 5.23e-01
GABA receptor activation 35 2.02e-02 6.33e-02 0.31300 0.272000 1.55e-01 5.32e-03 1.12e-01
FGFR1 ligand binding and activation 10 3.77e-01 5.04e-01 0.31300 -0.211000 -2.32e-01 2.48e-01 2.05e-01
RUNX3 regulates NOTCH signaling 14 1.57e-02 5.22e-02 0.31300 0.256000 -1.80e-01 9.68e-02 2.44e-01
Aspirin ADME 13 1.45e-01 2.65e-01 0.31300 0.302000 8.05e-02 5.92e-02 6.15e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 6.61e-04 3.94e-03 0.31300 0.137000 2.81e-01 6.15e-02 1.31e-04
Protein localization 157 9.43e-13 2.63e-11 0.31200 -0.311000 -3.31e-02 1.83e-11 4.74e-01
Metabolism of polyamines 46 3.39e-04 2.27e-03 0.31100 0.036500 3.09e-01 6.68e-01 2.85e-04
Metabolism of Angiotensinogen to Angiotensins 12 3.04e-01 4.39e-01 0.31100 0.247000 1.89e-01 1.39e-01 2.58e-01
E2F mediated regulation of DNA replication 22 5.41e-03 2.24e-02 0.31000 -0.064000 3.04e-01 6.03e-01 1.36e-02
Organic cation transport 8 1.77e-01 3.02e-01 0.31000 0.308000 -3.20e-02 1.31e-01 8.75e-01
Organic cation/anion/zwitterion transport 8 1.77e-01 3.02e-01 0.31000 0.308000 -3.20e-02 1.31e-01 8.75e-01
RORA activates gene expression 18 8.42e-02 1.80e-01 0.31000 0.295000 9.42e-02 3.01e-02 4.89e-01
Glycine degradation 7 5.05e-01 6.16e-01 0.31000 0.194000 2.42e-01 3.75e-01 2.68e-01
Transport of the SLBP independent Mature mRNA 35 3.31e-02 9.25e-02 0.30900 -0.243000 -1.92e-01 1.29e-02 4.95e-02
activated TAK1 mediates p38 MAPK activation 23 1.09e-01 2.17e-01 0.30900 0.238000 1.97e-01 4.81e-02 1.01e-01
Fibronectin matrix formation 6 4.17e-01 5.39e-01 0.30900 0.299000 7.84e-02 2.04e-01 7.39e-01
Sema4D mediated inhibition of cell attachment and migration 7 1.33e-01 2.52e-01 0.30900 0.174000 -2.55e-01 4.26e-01 2.42e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.16e-01 3.42e-01 0.30900 -0.296000 -8.81e-02 8.94e-02 6.13e-01
Activation of the AP-1 family of transcription factors 10 3.65e-01 4.97e-01 0.30800 0.254000 1.75e-01 1.65e-01 3.38e-01
HS-GAG biosynthesis 19 1.65e-01 2.87e-01 0.30800 0.204000 2.32e-01 1.24e-01 8.04e-02
Plasma lipoprotein remodeling 18 2.05e-02 6.36e-02 0.30800 0.306000 -3.45e-02 2.44e-02 8.00e-01
Degradation of AXIN 42 4.79e-04 2.97e-03 0.30800 0.017000 3.07e-01 8.49e-01 5.68e-04
RNA Polymerase I Transcription Initiation 47 7.15e-03 2.83e-02 0.30800 -0.264000 -1.59e-01 1.77e-03 5.97e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 2.39e-01 3.69e-01 0.30800 -0.290000 -1.03e-01 9.61e-02 5.54e-01
Regulation of MECP2 expression and activity 28 3.93e-02 1.04e-01 0.30700 0.132000 2.78e-01 2.26e-01 1.10e-02
Resolution of Sister Chromatid Cohesion 115 2.85e-07 4.24e-06 0.30700 0.100000 2.91e-01 6.37e-02 7.23e-08
Triglyceride metabolism 24 1.05e-01 2.12e-01 0.30700 0.229000 2.05e-01 5.23e-02 8.21e-02
NF-kB is activated and signals survival 12 1.92e-01 3.19e-01 0.30700 -0.088900 -2.94e-01 5.94e-01 7.78e-02
CLEC7A (Dectin-1) induces NFAT activation 11 2.46e-01 3.73e-01 0.30700 0.107000 2.88e-01 5.39e-01 9.85e-02
Miro GTPase Cycle 8 4.48e-01 5.64e-01 0.30700 0.254000 1.72e-01 2.13e-01 4.00e-01
Mitotic G1 phase and G1/S transition 138 3.09e-09 6.11e-08 0.30700 0.078800 2.96e-01 1.10e-01 1.83e-09
RHOF GTPase cycle 38 2.35e-02 7.04e-02 0.30600 0.251000 1.75e-01 7.40e-03 6.13e-02
Acyl chain remodelling of PI 10 3.92e-01 5.17e-01 0.30600 0.231000 2.00e-01 2.05e-01 2.73e-01
STAT3 nuclear events downstream of ALK signaling 11 3.55e-01 4.88e-01 0.30600 0.235000 1.96e-01 1.77e-01 2.61e-01
Pre-NOTCH Transcription and Translation 47 1.30e-02 4.57e-02 0.30500 0.225000 2.06e-01 7.55e-03 1.46e-02
Glycogen synthesis 11 9.53e-02 1.96e-01 0.30500 -0.037500 3.03e-01 8.30e-01 8.20e-02
Apoptotic cleavage of cell adhesion proteins 8 3.96e-01 5.20e-01 0.30500 0.127000 2.77e-01 5.34e-01 1.74e-01
Hemostasis 553 2.53e-22 1.52e-20 0.30500 0.218000 2.13e-01 1.83e-18 9.25e-18
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 4.01e-04 2.57e-03 0.30500 0.207000 2.24e-01 9.94e-04 3.53e-04
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 4.01e-04 2.57e-03 0.30500 0.207000 2.24e-01 9.94e-04 3.53e-04
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 4.01e-04 2.57e-03 0.30500 0.207000 2.24e-01 9.94e-04 3.53e-04
Activation of GABAB receptors 29 5.31e-02 1.29e-01 0.30500 0.258000 1.62e-01 1.63e-02 1.30e-01
GABA B receptor activation 29 5.31e-02 1.29e-01 0.30500 0.258000 1.62e-01 1.63e-02 1.30e-01
RAB geranylgeranylation 62 8.44e-04 4.88e-03 0.30400 0.128000 2.76e-01 8.07e-02 1.73e-04
The activation of arylsulfatases 10 3.34e-01 4.66e-01 0.30400 -0.271000 -1.39e-01 1.38e-01 4.48e-01
Formation of ATP by chemiosmotic coupling 20 1.50e-02 5.07e-02 0.30400 -0.302000 3.51e-02 1.96e-02 7.86e-01
Cyclin E associated events during G1/S transition 73 4.72e-05 4.14e-04 0.30400 0.083300 2.92e-01 2.18e-01 1.62e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.47e-06 1.90e-05 0.30200 -0.302000 -1.47e-02 5.27e-06 8.24e-01
PI-3K cascade:FGFR4 11 3.56e-01 4.89e-01 0.30200 0.241000 1.83e-01 1.67e-01 2.94e-01
Leading Strand Synthesis 14 1.90e-01 3.17e-01 0.30200 -0.279000 -1.15e-01 7.04e-02 4.57e-01
Polymerase switching 14 1.90e-01 3.17e-01 0.30200 -0.279000 -1.15e-01 7.04e-02 4.57e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 1.66e-09 3.39e-08 0.30200 0.142000 2.67e-01 7.29e-04 2.05e-10
Stabilization of p53 43 2.40e-04 1.67e-03 0.30200 -0.013500 3.01e-01 8.78e-01 6.29e-04
Cardiac conduction 88 3.03e-04 2.07e-03 0.30200 0.236000 1.88e-01 1.33e-04 2.29e-03
Signaling by VEGF 100 1.29e-04 9.92e-04 0.30100 0.214000 2.13e-01 2.23e-04 2.38e-04
Prolactin receptor signaling 11 4.88e-02 1.21e-01 0.30100 -0.176000 2.44e-01 3.13e-01 1.61e-01
Regulation of beta-cell development 21 9.89e-03 3.73e-02 0.30000 0.294000 -5.88e-02 1.96e-02 6.41e-01
Prostacyclin signalling through prostacyclin receptor 16 1.70e-01 2.95e-01 0.30000 0.127000 2.72e-01 3.79e-01 6.00e-02
p130Cas linkage to MAPK signaling for integrins 11 3.37e-01 4.69e-01 0.30000 0.157000 2.55e-01 3.67e-01 1.43e-01
Downstream signaling events of B Cell Receptor (BCR) 68 1.61e-04 1.19e-03 0.29900 0.089400 2.85e-01 2.03e-01 4.73e-05
RAB GEFs exchange GTP for GDP on RABs 89 3.51e-04 2.34e-03 0.29900 0.193000 2.28e-01 1.61e-03 2.02e-04
Synthesis of PI 5 2.57e-01 3.85e-01 0.29900 0.178000 -2.40e-01 4.90e-01 3.53e-01
Aquaporin-mediated transport 38 3.50e-02 9.55e-02 0.29900 0.216000 2.06e-01 2.13e-02 2.77e-02
Vesicle-mediated transport 663 9.36e-28 1.12e-25 0.29800 0.161000 2.51e-01 1.40e-12 2.61e-28
Neurofascin interactions 5 5.67e-01 6.67e-01 0.29800 0.274000 1.18e-01 2.89e-01 6.47e-01
Signaling by KIT in disease 20 6.67e-02 1.52e-01 0.29800 0.075600 2.88e-01 5.59e-01 2.56e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.67e-02 1.52e-01 0.29800 0.075600 2.88e-01 5.59e-01 2.56e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 1.64e-01 2.87e-01 0.29800 0.048800 2.94e-01 7.70e-01 7.82e-02
Activation of NF-kappaB in B cells 54 1.09e-03 6.06e-03 0.29700 0.090800 2.83e-01 2.49e-01 3.17e-04
Transcriptional Regulation by MECP2 47 1.51e-02 5.08e-02 0.29700 0.188000 2.30e-01 2.57e-02 6.30e-03
DAP12 signaling 28 4.28e-02 1.11e-01 0.29700 0.118000 2.73e-01 2.80e-01 1.24e-02
Incretin synthesis, secretion, and inactivation 14 1.65e-01 2.87e-01 0.29700 0.086000 2.84e-01 5.78e-01 6.53e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.65e-01 2.87e-01 0.29700 0.086000 2.84e-01 5.78e-01 6.53e-02
InlA-mediated entry of Listeria monocytogenes into host cells 9 3.23e-01 4.57e-01 0.29700 -0.282000 -9.17e-02 1.42e-01 6.34e-01
Regulation of insulin secretion 62 2.23e-03 1.12e-02 0.29700 0.256000 1.51e-01 5.00e-04 3.95e-02
Processive synthesis on the lagging strand 15 8.12e-02 1.75e-01 0.29700 -0.296000 -1.99e-02 4.70e-02 8.94e-01
Export of Viral Ribonucleoproteins from Nucleus 33 4.80e-02 1.20e-01 0.29700 -0.241000 -1.73e-01 1.65e-02 8.55e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 4.57e-02 1.16e-01 0.29700 0.280000 -9.85e-02 8.05e-02 5.39e-01
Mitochondrial tRNA aminoacylation 21 5.02e-02 1.23e-01 0.29700 -0.290000 -6.06e-02 2.13e-02 6.31e-01
Rev-mediated nuclear export of HIV RNA 35 3.77e-02 1.01e-01 0.29700 -0.246000 -1.66e-01 1.19e-02 8.93e-02
Cell-extracellular matrix interactions 15 2.41e-01 3.70e-01 0.29600 0.161000 2.48e-01 2.80e-01 9.57e-02
Potential therapeutics for SARS 148 1.14e-07 1.86e-06 0.29600 0.124000 2.69e-01 9.43e-03 1.67e-08
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.64e-02 1.17e-01 0.29600 -0.251000 -1.56e-01 1.39e-02 1.26e-01
RHOG GTPase cycle 70 2.00e-03 1.03e-02 0.29500 0.233000 1.82e-01 7.59e-04 8.55e-03
eNOS activation 10 7.83e-02 1.70e-01 0.29500 -0.142000 2.59e-01 4.37e-01 1.57e-01
Nectin/Necl trans heterodimerization 5 5.31e-01 6.38e-01 0.29500 0.282000 8.58e-02 2.74e-01 7.40e-01
TCF dependent signaling in response to WNT 151 1.24e-06 1.66e-05 0.29500 0.173000 2.39e-01 2.40e-04 4.07e-07
Regulation of TP53 Activity through Methylation 19 1.27e-01 2.43e-01 0.29500 -0.268000 -1.22e-01 4.29e-02 3.56e-01
Regulation of gene expression in beta cells 7 3.91e-01 5.17e-01 0.29500 0.286000 7.17e-02 1.90e-01 7.43e-01
CLEC7A/inflammasome pathway 6 2.24e-01 3.53e-01 0.29500 0.130000 -2.64e-01 5.81e-01 2.62e-01
Activation of AMPK downstream of NMDARs 20 1.80e-01 3.05e-01 0.29400 0.215000 2.01e-01 9.59e-02 1.20e-01
Evasion by RSV of host interferon responses 20 2.16e-02 6.62e-02 0.29400 -0.025400 2.93e-01 8.44e-01 2.33e-02
Regulation of APC/C activators between G1/S and early anaphase 68 1.68e-05 1.73e-04 0.29400 0.022900 2.93e-01 7.44e-01 2.93e-05
Viral Messenger RNA Synthesis 44 1.02e-02 3.79e-02 0.29400 -0.264000 -1.29e-01 2.46e-03 1.38e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 183 1.47e-09 3.08e-08 0.29400 0.113000 2.71e-01 8.66e-03 2.38e-10
Synthesis of Ketone Bodies 6 2.28e-01 3.58e-01 0.29400 -0.127000 2.65e-01 5.92e-01 2.61e-01
Rap1 signalling 14 2.90e-01 4.22e-01 0.29300 0.233000 1.78e-01 1.31e-01 2.49e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 3.30e-01 4.63e-01 0.29300 0.201000 2.14e-01 2.10e-01 1.82e-01
Sema4D induced cell migration and growth-cone collapse 19 7.51e-02 1.66e-01 0.29300 0.286000 6.50e-02 3.10e-02 6.24e-01
Complex IV assembly 45 1.05e-03 5.88e-03 0.29300 -0.291000 -3.68e-02 7.38e-04 6.69e-01
Packaging Of Telomere Ends 18 1.10e-01 2.18e-01 0.29300 0.089900 2.79e-01 5.09e-01 4.05e-02
FRS-mediated FGFR3 signaling 12 3.59e-01 4.91e-01 0.29300 0.216000 1.98e-01 1.94e-01 2.36e-01
MAP2K and MAPK activation 36 4.52e-02 1.15e-01 0.29200 0.225000 1.86e-01 1.94e-02 5.29e-02
Signaling by ERBB2 ECD mutants 15 2.81e-01 4.12e-01 0.29200 0.212000 2.01e-01 1.55e-01 1.79e-01
FGFR1 mutant receptor activation 25 1.14e-01 2.23e-01 0.29200 0.180000 2.30e-01 1.19e-01 4.69e-02
Unwinding of DNA 12 9.39e-02 1.95e-01 0.29200 -0.038800 2.89e-01 8.16e-01 8.28e-02
RUNX3 regulates p14-ARF 10 3.35e-01 4.67e-01 0.29200 0.269000 1.13e-01 1.41e-01 5.35e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 9.10e-04 5.22e-03 0.29200 -0.255000 -1.42e-01 1.86e-04 3.74e-02
Signaling by WNT in cancer 30 7.86e-02 1.71e-01 0.29200 0.219000 1.92e-01 3.79e-02 6.81e-02
EPHA-mediated growth cone collapse 21 1.28e-01 2.43e-01 0.29100 0.140000 2.55e-01 2.68e-01 4.27e-02
Dissolution of Fibrin Clot 12 4.87e-02 1.21e-01 0.29100 0.248000 -1.52e-01 1.36e-01 3.62e-01
DNA Damage Recognition in GG-NER 38 6.52e-03 2.62e-02 0.29100 -0.283000 -6.69e-02 2.55e-03 4.76e-01
Interleukin-12 signaling 44 1.78e-02 5.73e-02 0.29000 0.155000 2.45e-01 7.57e-02 4.91e-03
Generation of second messenger molecules 38 2.97e-03 1.39e-02 0.29000 -0.288000 -2.98e-02 2.10e-03 7.50e-01
Branched-chain amino acid catabolism 21 2.07e-02 6.39e-02 0.29000 -0.289000 2.22e-02 2.19e-02 8.60e-01
APC/C-mediated degradation of cell cycle proteins 75 1.05e-05 1.12e-04 0.28900 0.028300 2.88e-01 6.72e-01 1.66e-05
Regulation of mitotic cell cycle 75 1.05e-05 1.12e-04 0.28900 0.028300 2.88e-01 6.72e-01 1.66e-05
Synthesis of PIPs at the plasma membrane 52 1.31e-02 4.59e-02 0.28900 0.219000 1.88e-01 6.23e-03 1.92e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 7.52e-02 1.66e-01 0.28900 0.284000 -4.89e-02 7.58e-02 7.60e-01
Fatty acyl-CoA biosynthesis 35 4.62e-02 1.17e-01 0.28800 0.164000 2.37e-01 9.27e-02 1.52e-02
Acyl chain remodeling of CL 5 5.20e-01 6.29e-01 0.28800 0.065700 2.81e-01 7.99e-01 2.77e-01
Netrin-1 signaling 34 4.81e-02 1.20e-01 0.28800 0.241000 1.58e-01 1.51e-02 1.10e-01
Signaling by PDGF 48 7.31e-03 2.87e-02 0.28800 0.261000 1.22e-01 1.74e-03 1.45e-01
Apoptotic factor-mediated response 19 7.72e-03 3.01e-02 0.28800 -0.205000 2.02e-01 1.21e-01 1.28e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.08e-02 3.98e-02 0.28800 0.029700 2.86e-01 7.78e-01 6.65e-03
mRNA Splicing 211 2.87e-17 1.34e-15 0.28700 -0.286000 2.31e-02 7.64e-13 5.63e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 3.87e-02 1.03e-01 0.28700 -0.169000 2.32e-01 2.91e-01 1.48e-01
Cholesterol biosynthesis 26 1.13e-01 2.22e-01 0.28700 0.178000 2.25e-01 1.16e-01 4.70e-02
FGFR1b ligand binding and activation 5 5.09e-01 6.19e-01 0.28700 -0.281000 -5.49e-02 2.76e-01 8.32e-01
Regulation of PTEN stability and activity 55 1.12e-03 6.21e-03 0.28700 0.075500 2.76e-01 3.33e-01 3.89e-04
Dual Incision in GG-NER 41 2.73e-03 1.32e-02 0.28600 -0.284000 -3.89e-02 1.66e-03 6.66e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.02e-02 6.33e-02 0.28600 -0.264000 1.12e-01 6.00e-02 4.23e-01
Formation of TC-NER Pre-Incision Complex 51 6.21e-05 5.19e-04 0.28600 -0.284000 3.85e-02 4.53e-04 6.35e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 1.92e-01 3.19e-01 0.28600 0.127000 -2.57e-01 5.61e-01 2.39e-01
Synthesis, secretion, and deacylation of Ghrelin 11 6.22e-02 1.45e-01 0.28600 -0.215000 1.89e-01 2.16e-01 2.79e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 4.41e-01 5.58e-01 0.28600 0.245000 1.47e-01 2.03e-01 4.44e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 7.40e-02 1.64e-01 0.28600 -0.270000 -9.46e-02 2.50e-02 4.32e-01
FOXO-mediated transcription of cell death genes 16 2.27e-02 6.85e-02 0.28600 0.131000 -2.54e-01 3.64e-01 7.83e-02
Interactions of Rev with host cellular proteins 37 2.52e-02 7.39e-02 0.28600 -0.258000 -1.24e-01 6.69e-03 1.92e-01
Disorders of Developmental Biology 12 3.76e-01 5.04e-01 0.28600 0.188000 2.15e-01 2.58e-01 1.98e-01
Disorders of Nervous System Development 12 3.76e-01 5.04e-01 0.28600 0.188000 2.15e-01 2.58e-01 1.98e-01
Loss of function of MECP2 in Rett syndrome 12 3.76e-01 5.04e-01 0.28600 0.188000 2.15e-01 2.58e-01 1.98e-01
Pervasive developmental disorders 12 3.76e-01 5.04e-01 0.28600 0.188000 2.15e-01 2.58e-01 1.98e-01
Calcineurin activates NFAT 9 2.15e-01 3.42e-01 0.28500 -0.008770 2.85e-01 9.64e-01 1.39e-01
NIK–>noncanonical NF-kB signaling 46 4.66e-04 2.91e-03 0.28400 -0.003490 2.84e-01 9.67e-01 8.47e-04
Estrogen-dependent gene expression 96 4.52e-04 2.84e-03 0.28400 0.188000 2.13e-01 1.48e-03 3.07e-04
G1/S Transition 120 3.55e-08 6.20e-07 0.28400 0.035100 2.82e-01 5.07e-01 9.78e-08
Signaling by high-kinase activity BRAF mutants 33 6.93e-02 1.56e-01 0.28400 0.217000 1.82e-01 3.07e-02 6.97e-02
PKA-mediated phosphorylation of CREB 17 2.44e-01 3.71e-01 0.28400 0.227000 1.70e-01 1.05e-01 2.25e-01
PD-1 signaling 28 2.29e-02 6.91e-02 0.28400 -0.279000 -4.96e-02 1.05e-02 6.49e-01
mRNA Splicing - Major Pathway 203 8.71e-16 3.72e-14 0.28300 -0.283000 1.45e-02 3.70e-12 7.21e-01
Sialic acid metabolism 27 1.09e-01 2.17e-01 0.28300 0.224000 1.72e-01 4.35e-02 1.21e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 5.44e-04 3.31e-03 0.28300 0.026300 2.82e-01 7.45e-01 5.02e-04
Semaphorin interactions 56 3.23e-03 1.49e-02 0.28300 0.260000 1.10e-01 7.58e-04 1.53e-01
Muscle contraction 142 1.05e-05 1.12e-04 0.28200 0.222000 1.75e-01 5.18e-06 3.12e-04
PI-3K cascade:FGFR2 13 3.58e-01 4.90e-01 0.28200 0.197000 2.02e-01 2.19e-01 2.06e-01
TNFR1-mediated ceramide production 6 4.10e-01 5.34e-01 0.28200 -0.281000 -2.38e-02 2.33e-01 9.19e-01
Signaling by ROBO receptors 189 5.30e-14 1.70e-12 0.28200 -0.282000 5.49e-04 2.14e-11 9.90e-01
GPER1 signaling 38 4.97e-02 1.22e-01 0.28200 0.210000 1.87e-01 2.48e-02 4.56e-02
Phospholipase C-mediated cascade: FGFR1 8 4.74e-01 5.89e-01 0.28100 -0.129000 -2.50e-01 5.27e-01 2.22e-01
EPH-Ephrin signaling 79 1.71e-03 9.02e-03 0.28100 0.170000 2.23e-01 9.02e-03 6.02e-04
Apoptosis induced DNA fragmentation 10 1.53e-01 2.77e-01 0.28100 -0.046500 2.77e-01 7.99e-01 1.30e-01
Maturation of nucleoprotein 9694631 15 1.62e-01 2.86e-01 0.28000 0.068300 2.72e-01 6.47e-01 6.83e-02
Nuclear import of Rev protein 34 3.72e-02 9.99e-02 0.28000 -0.254000 -1.18e-01 1.04e-02 2.33e-01
Norepinephrine Neurotransmitter Release Cycle 14 8.82e-02 1.87e-01 0.28000 0.023200 -2.79e-01 8.80e-01 7.07e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 3.55e-01 4.88e-01 0.27900 0.238000 1.46e-01 1.53e-01 3.83e-01
Recognition of DNA damage by PCNA-containing replication complex 30 2.75e-03 1.33e-02 0.27900 -0.271000 6.62e-02 1.01e-02 5.30e-01
ERBB2 Activates PTK6 Signaling 8 1.65e-01 2.88e-01 0.27900 0.126000 -2.49e-01 5.38e-01 2.22e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 9 3.79e-01 5.06e-01 0.27900 0.263000 9.23e-02 1.71e-01 6.32e-01
Defective EXT2 causes exostoses 2 9 3.79e-01 5.06e-01 0.27900 0.263000 9.23e-02 1.71e-01 6.32e-01
Downstream signaling of activated FGFR3 17 2.66e-01 3.94e-01 0.27900 0.212000 1.81e-01 1.30e-01 1.97e-01
Signaling by EGFR in Cancer 22 1.25e-01 2.40e-01 0.27900 0.251000 1.21e-01 4.15e-02 3.26e-01
Peptide ligand-binding receptors 100 8.03e-08 1.33e-06 0.27900 0.278000 -9.89e-03 1.51e-06 8.64e-01
Phosphorylation of CD3 and TCR zeta chains 27 1.25e-02 4.43e-02 0.27800 -0.278000 7.93e-03 1.24e-02 9.43e-01
Postmitotic nuclear pore complex (NPC) reformation 27 8.30e-02 1.78e-01 0.27800 -0.248000 -1.26e-01 2.57e-02 2.58e-01
Metabolism of RNA 717 1.23e-43 1.19e-40 0.27800 -0.277000 -2.71e-02 1.30e-36 2.16e-01
Protein ubiquitination 71 9.25e-05 7.43e-04 0.27800 0.045700 2.74e-01 5.05e-01 6.50e-05
Assembly of active LPL and LIPC lipase complexes 10 2.76e-01 4.06e-01 0.27800 0.273000 4.99e-02 1.35e-01 7.85e-01
Complement cascade 100 2.58e-04 1.78e-03 0.27800 0.153000 2.32e-01 8.31e-03 6.09e-05
Synthesis of PIPs at the early endosome membrane 16 7.63e-02 1.67e-01 0.27800 -0.006500 2.77e-01 9.64e-01 5.46e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 9.16e-02 1.92e-01 0.27700 -0.263000 -8.70e-02 3.26e-02 4.80e-01
ER-Phagosome pathway 74 2.63e-06 3.21e-05 0.27700 -0.029900 2.76e-01 6.56e-01 4.13e-05
Platelet activation, signaling and aggregation 219 7.20e-08 1.21e-06 0.27700 0.198000 1.94e-01 4.59e-07 7.93e-07
Synthesis of PIPs at the late endosome membrane 11 1.07e-01 2.15e-01 0.27700 -0.085400 2.63e-01 6.24e-01 1.31e-01
SUMOylation of SUMOylation proteins 35 5.01e-02 1.23e-01 0.27700 -0.238000 -1.41e-01 1.48e-02 1.50e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.24e-02 4.42e-02 0.27600 0.007600 2.76e-01 9.44e-01 1.00e-02
Interleukin-27 signaling 11 3.73e-01 5.03e-01 0.27600 0.128000 2.45e-01 4.61e-01 1.60e-01
Myogenesis 20 6.67e-02 1.52e-01 0.27600 0.274000 3.48e-02 3.39e-02 7.87e-01
EML4 and NUDC in mitotic spindle formation 106 4.59e-06 5.37e-05 0.27600 0.069200 2.67e-01 2.18e-01 2.02e-06
p75NTR recruits signalling complexes 12 3.91e-01 5.17e-01 0.27600 -0.167000 -2.20e-01 3.16e-01 1.88e-01
Aerobic respiration and respiratory electron transport 245 6.26e-18 3.08e-16 0.27600 -0.275000 1.39e-02 1.09e-13 7.08e-01
Nephron development 5 6.64e-01 7.45e-01 0.27500 0.231000 1.50e-01 3.71e-01 5.62e-01
Signaling by FGFR1 in disease 32 8.96e-02 1.89e-01 0.27500 0.182000 2.06e-01 7.42e-02 4.37e-02
Interleukin-12 family signaling 53 1.21e-02 4.35e-02 0.27500 0.144000 2.34e-01 7.07e-02 3.15e-03
Peptide hormone metabolism 53 1.32e-02 4.61e-02 0.27500 0.149000 2.31e-01 6.03e-02 3.64e-03
RHOB GTPase cycle 64 1.59e-03 8.51e-03 0.27500 0.256000 9.85e-02 3.87e-04 1.73e-01
Removal of the Flap Intermediate from the C-strand 17 1.90e-02 6.04e-02 0.27500 -0.192000 1.97e-01 1.71e-01 1.61e-01
Erythropoietin activates STAT5 6 6.24e-01 7.14e-01 0.27500 0.223000 1.61e-01 3.45e-01 4.95e-01
Membrane Trafficking 575 8.16e-21 4.48e-19 0.27500 0.146000 2.32e-01 2.11e-09 1.51e-21
Cyclin D associated events in G1 47 7.60e-03 2.98e-02 0.27500 0.091500 2.59e-01 2.78e-01 2.14e-03
G1 Phase 47 7.60e-03 2.98e-02 0.27500 0.091500 2.59e-01 2.78e-01 2.14e-03
TLR3-mediated TICAM1-dependent programmed cell death 6 5.83e-01 6.80e-01 0.27400 0.124000 2.45e-01 6.00e-01 2.99e-01
Transcriptional regulation of pluripotent stem cells 18 2.35e-01 3.66e-01 0.27400 0.153000 2.28e-01 2.63e-01 9.41e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.62e-02 7.67e-02 0.27400 0.257000 9.68e-02 7.71e-03 3.15e-01
Separation of Sister Chromatids 167 4.78e-10 1.02e-08 0.27400 0.042200 2.71e-01 3.47e-01 1.51e-09
Formation of Incision Complex in GG-NER 43 1.03e-03 5.84e-03 0.27400 -0.274000 1.17e-02 1.88e-03 8.94e-01
G2/M Checkpoints 126 4.35e-07 6.23e-06 0.27400 0.065200 2.66e-01 2.07e-01 2.43e-07
Thromboxane signalling through TP receptor 20 1.92e-01 3.19e-01 0.27400 0.233000 1.44e-01 7.13e-02 2.64e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.16e-05 2.13e-04 0.27400 -0.271000 -4.38e-02 1.82e-05 4.87e-01
FRS-mediated FGFR4 signaling 13 3.79e-01 5.06e-01 0.27400 0.203000 1.84e-01 2.05e-01 2.52e-01
Glucagon-type ligand receptors 19 1.73e-01 2.99e-01 0.27300 0.116000 2.48e-01 3.82e-01 6.16e-02
PTK6 promotes HIF1A stabilization 6 4.76e-01 5.90e-01 0.27300 0.268000 5.10e-02 2.55e-01 8.29e-01
Antigen processing-Cross presentation 88 5.26e-06 6.04e-05 0.27300 0.024000 2.72e-01 6.97e-01 1.01e-05
Metalloprotease DUBs 20 2.26e-01 3.56e-01 0.27300 0.181000 2.04e-01 1.61e-01 1.14e-01
Integration of energy metabolism 87 7.00e-04 4.13e-03 0.27300 0.236000 1.37e-01 1.45e-04 2.69e-02
DNA Damage Bypass 47 4.97e-05 4.30e-04 0.27200 -0.246000 1.16e-01 3.53e-03 1.67e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.40e-02 7.12e-02 0.27200 0.002370 2.72e-01 9.84e-01 1.86e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.40e-02 7.12e-02 0.27200 0.002370 2.72e-01 9.84e-01 1.86e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 2.40e-02 7.12e-02 0.27200 0.002370 2.72e-01 9.84e-01 1.86e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 2.40e-02 7.12e-02 0.27200 0.002370 2.72e-01 9.84e-01 1.86e-02
Formation of paraxial mesoderm 52 1.22e-02 4.37e-02 0.27100 0.131000 2.38e-01 1.02e-01 3.02e-03
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 1.54e-01 2.78e-01 0.27100 0.059900 2.65e-01 6.78e-01 6.69e-02
Nucleotide Excision Repair 108 1.30e-06 1.73e-05 0.27100 -0.268000 -4.26e-02 1.51e-06 4.44e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 5.72e-02 1.37e-01 0.27100 -0.147000 2.28e-01 3.60e-01 1.55e-01
RSK activation 7 5.21e-01 6.30e-01 0.27100 0.108000 2.48e-01 6.20e-01 2.55e-01
APC/C:Cdc20 mediated degradation of Securin 55 7.93e-05 6.48e-04 0.27000 -0.041300 2.67e-01 5.96e-01 6.15e-04
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.21e-02 1.92e-01 0.27000 -0.265000 -5.27e-02 4.04e-02 6.83e-01
Recycling pathway of L1 40 4.17e-02 1.08e-01 0.27000 0.228000 1.44e-01 1.25e-02 1.15e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 7.01e-04 4.13e-03 0.26900 -0.257000 8.01e-02 6.06e-03 3.93e-01
Sema4D in semaphorin signaling 22 6.18e-02 1.44e-01 0.26900 0.267000 3.80e-02 3.04e-02 7.58e-01
Acetylcholine Neurotransmitter Release Cycle 11 2.83e-01 4.14e-01 0.26900 -0.059600 -2.62e-01 7.32e-01 1.32e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.51e-02 1.15e-01 0.26900 -0.167000 2.11e-01 2.79e-01 1.72e-01
Cyclin A:Cdk2-associated events at S phase entry 75 2.49e-04 1.72e-03 0.26900 0.066500 2.60e-01 3.19e-01 9.65e-05
Branched-chain ketoacid dehydrogenase kinase deficiency 5 5.36e-01 6.42e-01 0.26800 -0.265000 -3.98e-02 3.04e-01 8.77e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 1.18e-01 2.28e-01 0.26800 0.104000 2.48e-01 3.90e-01 3.97e-02
KEAP1-NFE2L2 pathway 106 5.56e-04 3.36e-03 0.26800 0.188000 1.90e-01 8.06e-04 7.06e-04
RNA Polymerase II Transcription Termination 66 4.77e-04 2.97e-03 0.26800 -0.262000 -5.43e-02 2.32e-04 4.46e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 7.01e-02 1.57e-01 0.26700 0.072700 2.57e-01 5.29e-01 2.61e-02
Removal of the Flap Intermediate 14 9.30e-02 1.94e-01 0.26700 -0.263000 4.40e-02 8.80e-02 7.76e-01
Signaling by FGFR3 in disease 14 3.61e-01 4.93e-01 0.26700 0.211000 1.63e-01 1.72e-01 2.90e-01
Hedgehog ‘on’ state 65 9.55e-04 5.46e-03 0.26700 0.069800 2.57e-01 3.30e-01 3.34e-04
Beta-oxidation of pristanoyl-CoA 9 1.80e-01 3.05e-01 0.26600 -0.086900 2.52e-01 6.52e-01 1.91e-01
RHOV GTPase cycle 36 2.65e-02 7.73e-02 0.26600 0.082100 2.53e-01 3.94e-01 8.53e-03
Voltage gated Potassium channels 26 9.09e-03 3.47e-02 0.26600 0.257000 -6.78e-02 2.32e-02 5.50e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.97e-01 3.25e-01 0.26600 0.156000 2.16e-01 2.06e-01 8.00e-02
Signaling by TGF-beta Receptor Complex in Cancer 8 1.77e-01 3.02e-01 0.26600 -0.167000 2.07e-01 4.14e-01 3.10e-01
Downstream signaling of activated FGFR4 18 2.79e-01 4.10e-01 0.26600 0.203000 1.72e-01 1.36e-01 2.08e-01
Dectin-1 mediated noncanonical NF-kB signaling 47 1.38e-03 7.48e-03 0.26500 0.005800 2.65e-01 9.45e-01 1.65e-03
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 5.16e-01 6.27e-01 0.26500 0.248000 9.39e-02 2.56e-01 6.67e-01
CD28 dependent PI3K/Akt signaling 22 1.87e-01 3.13e-01 0.26500 -0.143000 -2.23e-01 2.46e-01 7.00e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.77e-01 3.02e-01 0.26500 0.186000 -1.88e-01 3.62e-01 3.57e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 1.44e-01 2.65e-01 0.26400 0.007120 2.64e-01 9.63e-01 8.69e-02
Processing of Capped Intronless Pre-mRNA 29 2.71e-02 7.84e-02 0.26400 -0.262000 -3.20e-02 1.46e-02 7.66e-01
Phosphate bond hydrolysis by NTPDase proteins 6 5.61e-01 6.63e-01 0.26300 -0.249000 -8.67e-02 2.91e-01 7.13e-01
Formation of the cornified envelope 33 4.46e-02 1.15e-01 0.26300 0.247000 9.07e-02 1.40e-02 3.67e-01
TYSND1 cleaves peroxisomal proteins 7 3.28e-01 4.61e-01 0.26300 -0.261000 3.23e-02 2.31e-01 8.82e-01
Dual incision in TC-NER 63 5.58e-05 4.68e-04 0.26300 -0.262000 2.64e-02 3.24e-04 7.17e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 6.23e-02 1.45e-01 0.26300 0.135000 2.26e-01 1.62e-01 1.90e-02
Transcriptional regulation by RUNX1 170 9.60e-06 1.05e-04 0.26300 0.183000 1.89e-01 3.84e-05 2.17e-05
FRS-mediated FGFR2 signaling 15 3.53e-01 4.88e-01 0.26300 0.170000 2.00e-01 2.54e-01 1.79e-01
Respiratory syncytial virus (RSV) attachment and entry 17 1.87e-01 3.14e-01 0.26300 0.250000 8.00e-02 7.43e-02 5.68e-01
Adenylate cyclase inhibitory pathway 11 1.58e-01 2.83e-01 0.26200 0.257000 -5.05e-02 1.39e-01 7.72e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 1.35e-01 2.53e-01 0.26200 0.040900 2.59e-01 7.70e-01 6.44e-02
Pre-NOTCH Expression and Processing 63 1.36e-02 4.71e-02 0.26200 0.194000 1.76e-01 7.63e-03 1.57e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 90 9.27e-06 1.02e-04 0.26200 0.020100 2.61e-01 7.42e-01 1.81e-05
Amplification of signal from the kinetochores 90 9.27e-06 1.02e-04 0.26200 0.020100 2.61e-01 7.42e-01 1.81e-05
Sodium/Calcium exchangers 9 5.28e-01 6.36e-01 0.26200 0.210000 1.57e-01 2.75e-01 4.15e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 6.92e-02 1.56e-01 0.26200 0.085300 2.48e-01 4.35e-01 2.34e-02
Signaling by LTK 10 3.56e-01 4.89e-01 0.26200 0.253000 6.88e-02 1.67e-01 7.06e-01
Signaling by NTRK2 (TRKB) 20 2.31e-01 3.60e-01 0.26200 0.145000 2.18e-01 2.63e-01 9.15e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 4.97e-02 1.22e-01 0.26100 -0.208000 -1.57e-01 1.84e-02 7.44e-02
Assembly of the pre-replicative complex 87 1.45e-06 1.90e-05 0.26100 -0.030400 2.59e-01 6.25e-01 3.00e-05
FGFR1c ligand binding and activation 8 5.53e-01 6.55e-01 0.26100 -0.139000 -2.20e-01 4.95e-01 2.81e-01
Impaired BRCA2 binding to PALB2 24 3.25e-02 9.12e-02 0.26000 -0.008140 2.60e-01 9.45e-01 2.72e-02
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 6.30e-01 7.20e-01 0.26000 0.226000 1.29e-01 3.37e-01 5.85e-01
MECP2 regulates transcription of neuronal ligands 5 3.80e-01 5.06e-01 0.26000 -0.113000 2.34e-01 6.61e-01 3.65e-01
Regulation of TLR by endogenous ligand 15 2.05e-01 3.31e-01 0.26000 0.060100 2.53e-01 6.87e-01 9.02e-02
SARS-CoV-1-host interactions 94 1.88e-05 1.90e-04 0.25900 -0.256000 -3.92e-02 1.72e-05 5.12e-01
Degradation of the extracellular matrix 92 1.14e-04 8.96e-04 0.25900 0.249000 7.32e-02 3.68e-05 2.25e-01
Regulation of RUNX2 expression and activity 54 5.58e-04 3.36e-03 0.25900 -0.003120 2.59e-01 9.68e-01 9.74e-04
G1/S DNA Damage Checkpoints 54 1.86e-03 9.68e-03 0.25900 0.038200 2.57e-01 6.27e-01 1.11e-03
Loss of Function of SMAD2/3 in Cancer 7 2.40e-01 3.70e-01 0.25900 -0.212000 1.49e-01 3.32e-01 4.94e-01
Fanconi Anemia Pathway 36 6.67e-03 2.66e-02 0.25900 -0.259000 4.70e-03 7.18e-03 9.61e-01
Downregulation of ERBB4 signaling 8 1.96e-01 3.23e-01 0.25900 -0.154000 2.08e-01 4.51e-01 3.08e-01
Mismatch Repair 15 6.20e-02 1.44e-01 0.25900 -0.097700 2.39e-01 5.13e-01 1.08e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.50e-17 7.22e-16 0.25800 -0.258000 7.60e-03 1.09e-13 8.27e-01
RHOJ GTPase cycle 49 1.75e-02 5.65e-02 0.25800 0.234000 1.09e-01 4.52e-03 1.89e-01
Gluconeogenesis 19 2.74e-01 4.03e-01 0.25800 0.204000 1.59e-01 1.24e-01 2.30e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 1.10e-01 2.17e-01 0.25800 -0.254000 -4.80e-02 4.94e-02 7.10e-01
Synthesis of PIPs at the Golgi membrane 16 3.13e-01 4.48e-01 0.25800 -0.138000 -2.18e-01 3.39e-01 1.31e-01
Regulation of CDH11 function 9 3.74e-01 5.04e-01 0.25800 0.253000 4.98e-02 1.89e-01 7.96e-01
Signal transduction by L1 20 2.62e-01 3.91e-01 0.25800 0.198000 1.65e-01 1.24e-01 2.03e-01
Protein hydroxylation 17 2.11e-01 3.39e-01 0.25800 -0.243000 -8.66e-02 8.30e-02 5.37e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.06e-01 3.32e-01 0.25800 0.188000 1.76e-01 1.10e-01 1.36e-01
Signaling by WNT 237 9.34e-08 1.53e-06 0.25700 0.151000 2.08e-01 6.39e-05 3.23e-08
Downstream signaling of activated FGFR2 20 2.70e-01 3.98e-01 0.25700 0.178000 1.85e-01 1.68e-01 1.51e-01
SUMOylation of RNA binding proteins 47 3.40e-02 9.38e-02 0.25700 -0.217000 -1.37e-01 9.96e-03 1.05e-01
RNA Polymerase III Transcription Initiation 36 4.61e-02 1.17e-01 0.25600 -0.237000 -9.75e-02 1.38e-02 3.11e-01
Citric acid cycle (TCA cycle) 34 3.22e-03 1.49e-02 0.25600 -0.247000 6.72e-02 1.25e-02 4.98e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 2.08e-04 1.47e-03 0.25600 -0.256000 6.86e-03 4.98e-04 9.26e-01
Synthesis of Dolichyl-phosphate 6 6.61e-01 7.43e-01 0.25500 0.210000 1.46e-01 3.74e-01 5.36e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 4.12e-01 5.35e-01 0.25500 0.087900 2.40e-01 6.30e-01 1.89e-01
G alpha (z) signalling events 36 7.71e-02 1.69e-01 0.25500 0.216000 1.35e-01 2.47e-02 1.61e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 2.25e-01 3.54e-01 0.25400 0.087000 2.38e-01 5.35e-01 8.88e-02
Early SARS-CoV-2 Infection Events 30 7.23e-02 1.61e-01 0.25400 0.087100 2.38e-01 4.09e-01 2.39e-02
Gap junction degradation 11 4.80e-01 5.93e-01 0.25300 0.205000 1.48e-01 2.39e-01 3.94e-01
Gastrulation 73 8.50e-03 3.26e-02 0.25300 0.155000 2.00e-01 2.21e-02 3.13e-03
Adherens junctions interactions 37 4.76e-02 1.19e-01 0.25300 0.233000 9.79e-02 1.42e-02 3.03e-01
Mitophagy 38 6.99e-04 4.13e-03 0.25300 -0.212000 1.38e-01 2.40e-02 1.41e-01
Signaling by MET 67 1.47e-02 5.00e-02 0.25200 0.176000 1.81e-01 1.29e-02 1.02e-02
Acetylcholine regulates insulin secretion 9 1.94e-01 3.21e-01 0.25200 0.110000 -2.27e-01 5.67e-01 2.38e-01
Cellular responses to mechanical stimuli 83 1.91e-03 9.88e-03 0.25200 0.225000 1.14e-01 4.03e-04 7.29e-02
Response of endothelial cells to shear stress 83 1.91e-03 9.88e-03 0.25200 0.225000 1.14e-01 4.03e-04 7.29e-02
Interleukin-1 processing 8 3.87e-01 5.14e-01 0.25200 -0.020500 -2.51e-01 9.20e-01 2.19e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 6.76e-02 1.54e-01 0.25200 -0.197000 -1.57e-01 2.76e-02 7.84e-02
Transport of Mature Transcript to Cytoplasm 81 2.50e-03 1.23e-02 0.25100 -0.223000 -1.16e-01 5.36e-04 7.11e-02
Signaling by Interleukins 387 1.18e-11 3.11e-10 0.25100 0.205000 1.45e-01 4.38e-12 1.04e-06
MET receptor recycling 9 5.68e-01 6.67e-01 0.25100 0.188000 1.67e-01 3.30e-01 3.87e-01
RHO GTPases Activate Formins 127 1.27e-05 1.33e-04 0.25000 0.077100 2.38e-01 1.34e-01 3.58e-06
Interleukin-6 family signaling 18 3.23e-01 4.57e-01 0.25000 0.191000 1.61e-01 1.60e-01 2.37e-01
Folding of actin by CCT/TriC 10 1.82e-01 3.07e-01 0.25000 -0.087700 2.34e-01 6.31e-01 2.00e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 60 1.87e-02 5.97e-02 0.25000 0.207000 1.40e-01 5.57e-03 6.12e-02
p75NTR signals via NF-kB 15 1.62e-01 2.85e-01 0.25000 -0.010600 -2.49e-01 9.43e-01 9.44e-02
WNT mediated activation of DVL 8 2.20e-01 3.48e-01 0.25000 0.147000 -2.02e-01 4.72e-01 3.23e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 1.74e-04 1.27e-03 0.25000 -0.029100 2.48e-01 6.94e-01 8.12e-04
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.24e-02 1.61e-01 0.24900 -0.141000 2.05e-01 3.59e-01 1.84e-01
Mitotic Anaphase 210 2.02e-10 4.44e-09 0.24900 0.037500 2.46e-01 3.49e-01 7.56e-10
Post-chaperonin tubulin folding pathway 18 3.31e-01 4.64e-01 0.24900 0.182000 1.69e-01 1.80e-01 2.15e-01
RAC2 GTPase cycle 85 3.22e-03 1.49e-02 0.24800 0.211000 1.31e-01 7.73e-04 3.70e-02
Mitotic Metaphase and Anaphase 211 1.95e-10 4.36e-09 0.24800 0.036500 2.46e-01 3.60e-01 7.75e-10
TGF-beta receptor signaling activates SMADs 45 4.93e-02 1.21e-01 0.24800 0.134000 2.09e-01 1.21e-01 1.52e-02
Constitutive Signaling by AKT1 E17K in Cancer 25 1.56e-02 5.20e-02 0.24800 0.083500 -2.34e-01 4.70e-01 4.31e-02
Innate Immune System 966 1.29e-26 1.24e-24 0.24800 0.144000 2.02e-01 4.25e-14 1.83e-26
GP1b-IX-V activation signalling 10 4.38e-01 5.56e-01 0.24700 0.232000 8.72e-02 2.05e-01 6.33e-01
Switching of origins to a post-replicative state 79 1.14e-05 1.20e-04 0.24700 -0.039100 2.44e-01 5.48e-01 1.78e-04
Defects in vitamin and cofactor metabolism 21 4.78e-02 1.19e-01 0.24700 -0.243000 4.05e-02 5.35e-02 7.48e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 1.59e-01 2.84e-01 0.24700 -0.221000 -1.09e-01 5.54e-02 3.47e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 76 2.05e-05 2.03e-04 0.24600 -0.037500 2.43e-01 5.72e-01 2.49e-04
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 5.40e-01 6.46e-01 0.24500 -0.194000 -1.49e-01 2.87e-01 4.15e-01
Regulation of CDH11 gene transcription 5 4.22e-01 5.44e-01 0.24400 0.111000 -2.18e-01 6.67e-01 3.99e-01
Molecules associated with elastic fibres 26 1.55e-01 2.78e-01 0.24400 0.219000 1.09e-01 5.34e-02 3.37e-01
Na+/Cl- dependent neurotransmitter transporters 7 4.77e-01 5.90e-01 0.24400 0.242000 3.11e-02 2.67e-01 8.87e-01
DNA strand elongation 32 7.01e-03 2.77e-02 0.24400 -0.234000 6.87e-02 2.19e-02 5.01e-01
rRNA processing in the mitochondrion 24 1.72e-01 2.97e-01 0.24400 -0.221000 -1.03e-01 6.09e-02 3.82e-01
ESR-mediated signaling 157 1.03e-04 8.14e-04 0.24400 0.175000 1.70e-01 1.53e-04 2.42e-04
ABC-family proteins mediated transport 81 1.83e-03 9.58e-03 0.24400 0.091000 2.26e-01 1.57e-01 4.32e-04
Small interfering RNA (siRNA) biogenesis 9 2.39e-01 3.69e-01 0.24400 -0.078300 2.31e-01 6.84e-01 2.31e-01
RHOU GTPase cycle 40 9.52e-02 1.96e-01 0.24300 0.162000 1.81e-01 7.66e-02 4.71e-02
CDK-mediated phosphorylation and removal of Cdc6 60 7.96e-04 4.63e-03 0.24300 0.002420 2.43e-01 9.74e-01 1.13e-03
Keratan sulfate/keratin metabolism 27 1.60e-01 2.84e-01 0.24300 0.213000 1.17e-01 5.59e-02 2.91e-01
MAPK family signaling cascades 259 3.02e-07 4.42e-06 0.24300 0.163000 1.80e-01 6.62e-06 5.96e-07
Nitric oxide stimulates guanylate cyclase 15 8.29e-02 1.78e-01 0.24200 0.100000 -2.21e-01 5.02e-01 1.39e-01
Regulation of Expression and Function of Type II Classical Cadherins 23 1.45e-01 2.65e-01 0.24200 0.231000 7.33e-02 5.53e-02 5.43e-01
Regulation of Homotypic Cell-Cell Adhesion 23 1.45e-01 2.65e-01 0.24200 0.231000 7.33e-02 5.53e-02 5.43e-01
Beta-catenin independent WNT signaling 124 5.08e-04 3.11e-03 0.24200 0.140000 1.98e-01 7.23e-03 1.44e-04
Cristae formation 33 1.36e-02 4.71e-02 0.24200 -0.241000 2.19e-02 1.66e-02 8.28e-01
Hyaluronan metabolism 15 6.78e-02 1.54e-01 0.24200 0.185000 -1.56e-01 2.15e-01 2.97e-01
Estrogen-stimulated signaling through PRKCZ 6 5.61e-01 6.63e-01 0.24200 0.045400 2.37e-01 8.47e-01 3.14e-01
mRNA 3’-end processing 57 4.56e-03 1.99e-02 0.24100 -0.236000 -4.84e-02 2.02e-03 5.28e-01
A tetrasaccharide linker sequence is required for GAG synthesis 16 9.44e-02 1.95e-01 0.24100 0.058700 -2.34e-01 6.85e-01 1.05e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 2.81e-01 4.11e-01 0.24100 -0.017100 2.40e-01 9.26e-01 1.88e-01
RNA Polymerase III Abortive And Retractive Initiation 40 5.87e-02 1.38e-01 0.24100 -0.217000 -1.04e-01 1.74e-02 2.55e-01
RNA Polymerase III Transcription 40 5.87e-02 1.38e-01 0.24100 -0.217000 -1.04e-01 1.74e-02 2.55e-01
FLT3 Signaling 38 1.00e-01 2.04e-01 0.24100 0.195000 1.41e-01 3.71e-02 1.33e-01
RET signaling 32 8.03e-02 1.74e-01 0.24100 0.226000 8.25e-02 2.69e-02 4.19e-01
Regulation of RUNX3 expression and activity 45 7.66e-03 2.99e-02 0.24000 0.018700 2.40e-01 8.28e-01 5.41e-03
Defective factor IX causes hemophilia B 6 6.21e-01 7.12e-01 0.24000 0.226000 8.07e-02 3.37e-01 7.32e-01
p53-Dependent G1 DNA Damage Response 52 4.46e-03 1.96e-02 0.24000 0.026900 2.39e-01 7.37e-01 2.89e-03
p53-Dependent G1/S DNA damage checkpoint 52 4.46e-03 1.96e-02 0.24000 0.026900 2.39e-01 7.37e-01 2.89e-03
Trafficking of GluR2-containing AMPA receptors 11 4.50e-01 5.66e-01 0.24000 0.219000 9.74e-02 2.08e-01 5.76e-01
Formation of tubulin folding intermediates by CCT/TriC 21 2.94e-01 4.26e-01 0.24000 0.150000 1.87e-01 2.34e-01 1.38e-01
PIWI-interacting RNA (piRNA) biogenesis 23 1.85e-02 5.90e-02 0.24000 -0.196000 1.38e-01 1.03e-01 2.54e-01
TGFBR3 regulates TGF-beta signaling 8 3.01e-01 4.35e-01 0.23900 -0.229000 7.01e-02 2.63e-01 7.32e-01
RND3 GTPase cycle 35 1.36e-01 2.54e-01 0.23800 0.183000 1.53e-01 6.13e-02 1.18e-01
Signaling by FGFR3 32 1.50e-01 2.72e-01 0.23800 0.139000 1.94e-01 1.75e-01 5.80e-02
Metabolism of nitric oxide: NOS3 activation and regulation 13 1.22e-01 2.35e-01 0.23800 -0.103000 2.14e-01 5.18e-01 1.81e-01
Activation of Ca-permeable Kainate Receptor 8 6.12e-01 7.05e-01 0.23800 0.129000 2.00e-01 5.28e-01 3.27e-01
Ionotropic activity of kainate receptors 8 6.12e-01 7.05e-01 0.23800 0.129000 2.00e-01 5.28e-01 3.27e-01
NRIF signals cell death from the nucleus 15 1.83e-01 3.08e-01 0.23800 -0.238000 -3.96e-03 1.11e-01 9.79e-01
Physiological factors 9 5.99e-01 6.94e-01 0.23700 0.150000 1.84e-01 4.36e-01 3.39e-01
Metabolism of amino acids and derivatives 304 8.18e-15 3.14e-13 0.23700 -0.237000 -1.35e-02 1.21e-12 6.86e-01
RHOA GTPase cycle 138 1.42e-04 1.07e-03 0.23700 0.207000 1.15e-01 2.62e-05 1.95e-02
Ketone body metabolism 8 2.93e-01 4.25e-01 0.23700 -0.083000 2.22e-01 6.85e-01 2.77e-01
Potassium Channels 62 1.16e-03 6.40e-03 0.23700 0.237000 1.08e-02 1.26e-03 8.83e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.45e-01 2.65e-01 0.23700 -0.198000 -1.30e-01 5.27e-02 2.02e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.45e-01 2.65e-01 0.23700 -0.198000 -1.30e-01 5.27e-02 2.02e-01
Respiratory Syncytial Virus Infection Pathway 97 5.13e-06 5.97e-05 0.23600 -0.025300 2.35e-01 6.66e-01 6.51e-05
Transferrin endocytosis and recycling 26 1.26e-01 2.41e-01 0.23600 0.225000 7.14e-02 4.72e-02 5.29e-01
Organic anion transporters 7 5.57e-01 6.59e-01 0.23600 -0.227000 -6.27e-02 2.97e-01 7.74e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 1.28e-01 2.43e-01 0.23500 0.111000 2.07e-01 2.75e-01 4.26e-02
Keratinization 34 6.25e-02 1.45e-01 0.23500 0.226000 6.51e-02 2.28e-02 5.11e-01
Defects of platelet adhesion to exposed collagen 6 5.52e-01 6.55e-01 0.23500 0.233000 2.73e-02 3.23e-01 9.08e-01
Signaling by RAF1 mutants 36 1.40e-01 2.60e-01 0.23500 0.169000 1.63e-01 7.86e-02 9.15e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 1.13e-01 2.21e-01 0.23500 -0.223000 -7.33e-02 4.13e-02 5.02e-01
FGFR3 ligand binding and activation 5 7.59e-01 8.25e-01 0.23400 0.179000 1.51e-01 4.88e-01 5.59e-01
FGFR3c ligand binding and activation 5 7.59e-01 8.25e-01 0.23400 0.179000 1.51e-01 4.88e-01 5.59e-01
Release of apoptotic factors from the mitochondria 6 4.14e-01 5.37e-01 0.23400 -0.221000 7.57e-02 3.48e-01 7.48e-01
AKT phosphorylates targets in the cytosol 14 9.53e-02 1.96e-01 0.23300 0.157000 -1.73e-01 3.10e-01 2.63e-01
Signaling by Rho GTPases 603 1.78e-14 6.02e-13 0.23300 0.160000 1.70e-01 2.19e-11 9.86e-13
Blood group systems biosynthesis 16 4.23e-01 5.45e-01 0.23300 -0.163000 -1.67e-01 2.60e-01 2.47e-01
Regulation of CDH11 Expression and Function 22 2.59e-01 3.88e-01 0.23300 0.202000 1.17e-01 1.01e-01 3.43e-01
Mitotic G2-G2/M phases 179 5.16e-07 7.13e-06 0.23300 0.061300 2.24e-01 1.57e-01 2.22e-07
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 3.15e-01 4.50e-01 0.23200 0.106000 2.07e-01 4.38e-01 1.29e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 3.15e-01 4.50e-01 0.23200 0.106000 2.07e-01 4.38e-01 1.29e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.35e-02 9.27e-02 0.23200 -0.193000 1.29e-01 1.26e-01 3.06e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.35e-02 9.27e-02 0.23200 -0.193000 1.29e-01 1.26e-01 3.06e-01
Metabolism of fat-soluble vitamins 26 5.54e-02 1.33e-01 0.23200 0.231000 -4.24e-03 4.10e-02 9.70e-01
Cell Cycle Checkpoints 245 4.04e-11 9.96e-10 0.23100 0.021700 2.30e-01 5.59e-01 5.26e-10
Integrin cell surface interactions 64 2.22e-02 6.77e-02 0.23100 0.198000 1.19e-01 6.03e-03 1.00e-01
RHOD GTPase cycle 49 5.69e-02 1.36e-01 0.23100 0.196000 1.22e-01 1.75e-02 1.40e-01
G2/M Transition 177 8.03e-07 1.09e-05 0.23100 0.061900 2.23e-01 1.55e-01 3.26e-07
Autodegradation of Cdh1 by Cdh1:APC/C 54 5.53e-04 3.35e-03 0.23100 -0.065600 2.21e-01 4.04e-01 4.90e-03
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 1.62e-14 5.55e-13 0.23100 0.159000 1.68e-01 1.65e-11 1.10e-12
APC-Cdc20 mediated degradation of Nek2A 26 1.50e-02 5.08e-02 0.23100 -0.186000 1.36e-01 9.99e-02 2.31e-01
Signaling by NTRK3 (TRKC) 15 3.74e-01 5.04e-01 0.23100 0.209000 9.79e-02 1.61e-01 5.12e-01
Suppression of apoptosis 7 5.44e-01 6.49e-01 0.23000 0.226000 4.50e-02 3.00e-01 8.37e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.36e-03 1.93e-02 0.23000 -0.189000 1.31e-01 5.61e-02 1.86e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 2.67e-01 3.95e-01 0.23000 -0.229000 2.49e-02 1.89e-01 8.86e-01
Budding and maturation of HIV virion 26 5.61e-02 1.35e-01 0.23000 -0.006820 2.30e-01 9.52e-01 4.28e-02
NOTCH4 Intracellular Domain Regulates Transcription 17 7.31e-02 1.62e-01 0.22900 0.201000 -1.10e-01 1.51e-01 4.31e-01
PKR-mediated signaling 67 2.11e-03 1.08e-02 0.22900 0.031400 2.27e-01 6.57e-01 1.31e-03
RAF activation 32 9.09e-02 1.91e-01 0.22900 0.069700 2.18e-01 4.95e-01 3.27e-02
MET promotes cell motility 32 1.66e-01 2.89e-01 0.22900 0.190000 1.27e-01 6.22e-02 2.14e-01
Regulation of BACH1 activity 11 1.70e-01 2.95e-01 0.22900 -0.174000 1.49e-01 3.17e-01 3.94e-01
Formation of annular gap junctions 10 5.88e-01 6.85e-01 0.22900 0.179000 1.43e-01 3.28e-01 4.35e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 1.26e-01 2.41e-01 0.22800 -0.070300 2.17e-01 6.37e-01 1.45e-01
DNA Damage Reversal 8 6.53e-01 7.36e-01 0.22800 -0.180000 -1.40e-01 3.78e-01 4.93e-01
MAPK1/MAPK3 signaling 227 9.32e-06 1.02e-04 0.22800 0.158000 1.65e-01 4.20e-05 1.91e-05
Processive synthesis on the C-strand of the telomere 19 4.93e-02 1.21e-01 0.22800 -0.181000 1.38e-01 1.71e-01 2.98e-01
IRF3-mediated induction of type I IFN 12 5.29e-01 6.37e-01 0.22800 -0.180000 -1.40e-01 2.80e-01 4.02e-01
Mitotic Prometaphase 192 7.88e-08 1.32e-06 0.22800 0.042100 2.24e-01 3.14e-01 9.03e-08
Purine salvage 12 3.09e-01 4.45e-01 0.22800 0.016300 2.27e-01 9.22e-01 1.73e-01
Formation of axial mesoderm 6 4.96e-01 6.08e-01 0.22700 0.226000 -2.37e-02 3.37e-01 9.20e-01
Activation of NOXA and translocation to mitochondria 5 4.57e-01 5.73e-01 0.22700 -0.186000 1.31e-01 4.71e-01 6.13e-01
Formation of the Early Elongation Complex 33 4.57e-02 1.16e-01 0.22700 -0.226000 -2.48e-02 2.47e-02 8.05e-01
Formation of the HIV-1 Early Elongation Complex 33 4.57e-02 1.16e-01 0.22700 -0.226000 -2.48e-02 2.47e-02 8.05e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.72e-03 9.04e-03 0.22700 -0.157000 1.64e-01 8.56e-02 7.25e-02
Base Excision Repair 56 2.88e-03 1.38e-02 0.22700 -0.227000 -8.51e-04 3.30e-03 9.91e-01
Diseases of DNA repair 50 4.93e-04 3.04e-03 0.22700 -0.195000 1.16e-01 1.71e-02 1.55e-01
Diseases of hemostasis 13 4.46e-01 5.64e-01 0.22700 0.203000 1.00e-01 2.04e-01 5.31e-01
Interleukin-23 signaling 7 4.46e-01 5.64e-01 0.22600 -0.023100 2.25e-01 9.16e-01 3.02e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 3.40e-01 4.72e-01 0.22600 0.214000 7.21e-02 1.50e-01 6.29e-01
SHC1 events in ERBB4 signaling 10 3.17e-01 4.50e-01 0.22600 0.225000 -2.30e-02 2.19e-01 9.00e-01
Signaling by activated point mutants of FGFR1 5 6.52e-01 7.35e-01 0.22600 -0.039500 -2.22e-01 8.78e-01 3.90e-01
Deadenylation-dependent mRNA decay 50 5.67e-04 3.39e-03 0.22500 -0.196000 1.12e-01 1.67e-02 1.70e-01
Cargo trafficking to the periciliary membrane 48 8.73e-04 5.03e-03 0.22500 -0.104000 1.99e-01 2.11e-01 1.68e-02
TGFBR3 expression 20 3.63e-01 4.95e-01 0.22500 0.146000 1.71e-01 2.57e-01 1.86e-01
FGFR2c ligand binding and activation 5 7.70e-01 8.35e-01 0.22500 0.180000 1.35e-01 4.86e-01 6.01e-01
RA biosynthesis pathway 13 2.96e-01 4.28e-01 0.22400 -0.224000 -1.91e-02 1.63e-01 9.05e-01
Meiotic synapsis 43 4.71e-02 1.18e-01 0.22400 0.069600 2.13e-01 4.30e-01 1.57e-02
FGFR2 mutant receptor activation 23 1.30e-01 2.47e-01 0.22300 -0.222000 -2.84e-02 6.58e-02 8.14e-01
Telomere Extension By Telomerase 23 1.98e-01 3.26e-01 0.22300 0.070500 2.12e-01 5.58e-01 7.84e-02
RUNX2 regulates bone development 21 3.54e-01 4.88e-01 0.22300 0.166000 1.50e-01 1.89e-01 2.35e-01
Spry regulation of FGF signaling 16 3.56e-01 4.89e-01 0.22300 0.084400 2.06e-01 5.59e-01 1.54e-01
Signaling by ERBB2 in Cancer 21 2.62e-01 3.91e-01 0.22300 0.205000 8.65e-02 1.04e-01 4.93e-01
S Phase 150 3.44e-08 6.07e-07 0.22200 -0.032100 2.20e-01 4.98e-01 3.43e-06
SUMOylation of immune response proteins 12 2.02e-01 3.30e-01 0.22200 0.074500 -2.09e-01 6.55e-01 2.10e-01
Golgi Associated Vesicle Biogenesis 55 4.51e-02 1.15e-01 0.22200 0.108000 1.94e-01 1.66e-01 1.29e-02
DNA Replication Pre-Initiation 103 1.97e-06 2.50e-05 0.22200 -0.062100 2.13e-01 2.76e-01 1.89e-04
DNA Damage/Telomere Stress Induced Senescence 42 1.17e-01 2.28e-01 0.22200 0.131000 1.79e-01 1.43e-01 4.46e-02
Ub-specific processing proteases 153 1.01e-05 1.09e-04 0.22200 0.054500 2.15e-01 2.45e-01 4.46e-06
Extracellular matrix organization 213 1.28e-07 2.03e-06 0.22200 0.215000 5.54e-02 6.75e-08 1.64e-01
Opioid Signalling 74 2.40e-02 7.14e-02 0.22100 0.177000 1.33e-01 8.56e-03 4.72e-02
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 5.75e-02 1.37e-01 0.22100 -0.191000 -1.12e-01 1.72e-02 1.62e-01
VEGF binds to VEGFR leading to receptor dimerization 5 5.78e-01 6.75e-01 0.22100 0.220000 -2.14e-02 3.94e-01 9.34e-01
VEGF ligand-receptor interactions 5 5.78e-01 6.75e-01 0.22100 0.220000 -2.14e-02 3.94e-01 9.34e-01
Biosynthesis of maresins 5 7.85e-01 8.47e-01 0.22100 0.161000 1.51e-01 5.33e-01 5.58e-01
Class A/1 (Rhodopsin-like receptors) 176 5.08e-07 7.07e-06 0.22100 0.218000 3.59e-02 6.19e-07 4.11e-01
Chondroitin sulfate biosynthesis 12 2.88e-01 4.19e-01 0.22100 0.220000 -9.79e-03 1.86e-01 9.53e-01
Interleukin-1 family signaling 127 2.12e-03 1.08e-02 0.22100 0.144000 1.67e-01 5.07e-03 1.14e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 2.18e-03 1.10e-02 0.22100 -0.168000 1.43e-01 6.25e-02 1.14e-01
Diseases of DNA Double-Strand Break Repair 41 2.18e-03 1.10e-02 0.22100 -0.168000 1.43e-01 6.25e-02 1.14e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.88e-01 5.14e-01 0.22100 0.185000 1.20e-01 1.74e-01 3.79e-01
Cellular response to chemical stress 178 1.96e-04 1.40e-03 0.22000 0.147000 1.64e-01 7.08e-04 1.62e-04
Metabolism of steroids 120 2.65e-03 1.30e-02 0.22000 0.134000 1.75e-01 1.15e-02 9.39e-04
Deposition of new CENPA-containing nucleosomes at the centromere 37 1.68e-02 5.49e-02 0.22000 -0.025900 2.18e-01 7.85e-01 2.15e-02
Nucleosome assembly 37 1.68e-02 5.49e-02 0.22000 -0.025900 2.18e-01 7.85e-01 2.15e-02
Cell-Cell communication 108 5.45e-03 2.25e-02 0.22000 0.168000 1.42e-01 2.60e-03 1.08e-02
Ion homeostasis 40 1.47e-01 2.68e-01 0.22000 0.162000 1.48e-01 7.57e-02 1.05e-01
Rab regulation of trafficking 122 2.97e-03 1.39e-02 0.21900 0.147000 1.63e-01 5.04e-03 1.88e-03
SHC-mediated cascade:FGFR3 10 6.20e-01 7.12e-01 0.21900 0.147000 1.63e-01 4.22e-01 3.72e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 2.45e-01 3.72e-01 0.21900 0.178000 1.27e-01 1.02e-01 2.44e-01
Programmed Cell Death 186 5.06e-07 7.07e-06 0.21900 0.042500 2.15e-01 3.17e-01 4.39e-07
VEGFR2 mediated cell proliferation 18 4.25e-01 5.47e-01 0.21900 0.148000 1.61e-01 2.75e-01 2.38e-01
Molybdenum cofactor biosynthesis 6 4.78e-01 5.91e-01 0.21800 -0.210000 5.84e-02 3.72e-01 8.04e-01
Negative regulation of FLT3 15 4.85e-01 5.98e-01 0.21800 0.138000 1.69e-01 3.54e-01 2.57e-01
RAF/MAP kinase cascade 222 3.13e-05 2.94e-04 0.21800 0.151000 1.58e-01 1.07e-04 5.22e-05
Mitotic Spindle Checkpoint 107 7.69e-06 8.64e-05 0.21800 -0.029900 2.16e-01 5.93e-01 1.13e-04
Creatine metabolism 7 7.13e-01 7.86e-01 0.21800 0.171000 1.35e-01 4.34e-01 5.36e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 5.72e-01 6.70e-01 0.21800 -0.209000 -6.14e-02 3.06e-01 7.64e-01
Apoptosis 157 2.23e-06 2.78e-05 0.21800 0.029100 2.16e-01 5.29e-01 3.09e-06
Signaling by NOTCH4 68 1.55e-02 5.19e-02 0.21700 0.082400 2.01e-01 2.40e-01 4.16e-03
Pyruvate metabolism 44 4.16e-03 1.86e-02 0.21700 -0.066800 2.06e-01 4.43e-01 1.79e-02
Thrombin signalling through proteinase activated receptors (PARs) 27 1.95e-01 3.23e-01 0.21700 0.200000 8.40e-02 7.25e-02 4.50e-01
SARS-CoV-2-host interactions 181 4.01e-06 4.75e-05 0.21600 -0.208000 -5.96e-02 1.45e-06 1.67e-01
Regulation of pyruvate metabolism 32 9.96e-02 2.03e-01 0.21600 0.052000 2.09e-01 6.11e-01 4.03e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.97e-02 1.05e-01 0.21600 -0.212000 -4.04e-02 1.75e-02 6.51e-01
HIV Transcription Elongation 42 3.97e-02 1.05e-01 0.21600 -0.212000 -4.04e-02 1.75e-02 6.51e-01
Tat-mediated elongation of the HIV-1 transcript 42 3.97e-02 1.05e-01 0.21600 -0.212000 -4.04e-02 1.75e-02 6.51e-01
Cell Cycle, Mitotic 487 1.15e-16 5.24e-15 0.21500 0.039800 2.12e-01 1.33e-01 1.19e-15
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.18e-01 2.30e-01 0.21500 0.034000 2.12e-01 7.60e-01 5.63e-02
SUMOylation of chromatin organization proteins 57 4.07e-02 1.07e-01 0.21500 -0.194000 -9.30e-02 1.14e-02 2.25e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 5.21e-02 1.27e-01 0.21500 0.214000 -1.77e-02 4.61e-02 8.69e-01
M Phase 345 2.95e-12 8.09e-11 0.21400 0.035200 2.11e-01 2.61e-01 1.47e-11
RSV-host interactions 76 1.05e-04 8.29e-04 0.21400 -0.063800 2.04e-01 3.36e-01 2.06e-03
Asparagine N-linked glycosylation 284 1.41e-07 2.21e-06 0.21400 0.091600 1.93e-01 7.90e-03 2.02e-08
TCR signaling 110 6.57e-05 5.42e-04 0.21400 0.012200 2.14e-01 8.26e-01 1.08e-04
GRB2 events in ERBB2 signaling 11 2.38e-01 3.68e-01 0.21400 0.193000 -9.21e-02 2.67e-01 5.97e-01
Pausing and recovery of Tat-mediated HIV elongation 30 1.37e-01 2.56e-01 0.21400 -0.204000 -6.30e-02 5.27e-02 5.50e-01
Tat-mediated HIV elongation arrest and recovery 30 1.37e-01 2.56e-01 0.21400 -0.204000 -6.30e-02 5.27e-02 5.50e-01
UCH proteinases 73 1.16e-02 4.21e-02 0.21400 0.076100 2.00e-01 2.61e-01 3.17e-03
Homologous DNA Pairing and Strand Exchange 43 2.45e-03 1.22e-02 0.21300 -0.163000 1.37e-01 6.38e-02 1.19e-01
Retrograde transport at the Trans-Golgi-Network 49 5.04e-03 2.13e-02 0.21300 -0.035800 2.10e-01 6.65e-01 1.11e-02
ISG15 antiviral mechanism 72 4.93e-05 4.28e-04 0.21300 -0.170000 1.28e-01 1.27e-02 5.98e-02
Pyroptosis 24 8.61e-02 1.84e-01 0.21300 -0.022300 2.12e-01 8.50e-01 7.27e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 4.71e-03 2.04e-02 0.21300 0.202000 6.67e-02 1.37e-03 2.90e-01
Meiotic recombination 36 2.13e-02 6.55e-02 0.21300 -0.033700 2.10e-01 7.26e-01 2.92e-02
G alpha (s) signalling events 93 1.32e-02 4.61e-02 0.21200 0.171000 1.27e-01 4.45e-03 3.49e-02
Hyaluronan uptake and degradation 12 2.37e-01 3.68e-01 0.21200 0.202000 -6.58e-02 2.26e-01 6.93e-01
FGFR2 alternative splicing 25 2.42e-01 3.70e-01 0.21200 -0.194000 -8.57e-02 9.31e-02 4.58e-01
Tryptophan catabolism 12 1.92e-01 3.19e-01 0.21200 -0.163000 1.35e-01 3.28e-01 4.18e-01
Nuclear Receptor transcription pathway 38 5.30e-03 2.21e-02 0.21100 0.150000 -1.49e-01 1.10e-01 1.12e-01
Defects in cobalamin (B12) metabolism 13 2.15e-01 3.42e-01 0.21100 -0.064900 2.01e-01 6.85e-01 2.10e-01
ABC transporters in lipid homeostasis 14 3.66e-01 4.97e-01 0.21100 -0.043600 -2.06e-01 7.78e-01 1.81e-01
Transcriptional Regulation by E2F6 34 9.40e-03 3.57e-02 0.21100 -0.151000 1.47e-01 1.27e-01 1.38e-01
Metabolism of amine-derived hormones 10 2.55e-01 3.84e-01 0.21100 0.161000 -1.36e-01 3.78e-01 4.56e-01
Methylation 13 3.72e-01 5.02e-01 0.21100 -0.208000 -3.28e-02 1.94e-01 8.38e-01
Uptake and actions of bacterial toxins 27 2.06e-01 3.32e-01 0.21000 0.196000 7.72e-02 7.83e-02 4.88e-01
DNA Replication 128 4.40e-07 6.26e-06 0.21000 -0.058000 2.02e-01 2.57e-01 7.74e-05
Constitutive Signaling by Aberrant PI3K in Cancer 57 1.42e-02 4.87e-02 0.21000 0.207000 3.48e-02 6.83e-03 6.49e-01
Glycogen breakdown (glycogenolysis) 12 5.92e-01 6.88e-01 0.21000 0.144000 1.53e-01 3.89e-01 3.59e-01
MITF-M-dependent gene expression 81 2.90e-02 8.32e-02 0.21000 0.156000 1.40e-01 1.52e-02 2.91e-02
Translation of Structural Proteins 9683701 29 1.12e-01 2.20e-01 0.21000 0.032700 2.07e-01 7.61e-01 5.34e-02
RHOT2 GTPase cycle 7 6.97e-01 7.74e-01 0.21000 0.185000 9.81e-02 3.96e-01 6.53e-01
Trafficking and processing of endosomal TLR 13 5.18e-01 6.28e-01 0.21000 0.101000 1.83e-01 5.27e-01 2.52e-01
Activation of SMO 14 5.45e-01 6.49e-01 0.20900 0.146000 1.50e-01 3.44e-01 3.31e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 1.35e-01 2.54e-01 0.20900 0.209000 -1.38e-02 9.76e-02 9.13e-01
Loss of Function of TGFBR1 in Cancer 7 3.95e-01 5.20e-01 0.20900 -0.123000 1.69e-01 5.74e-01 4.39e-01
Zinc influx into cells by the SLC39 gene family 9 6.16e-01 7.08e-01 0.20900 0.189000 8.82e-02 3.26e-01 6.47e-01
Regulated proteolysis of p75NTR 11 4.66e-01 5.82e-01 0.20900 0.204000 4.52e-02 2.42e-01 7.95e-01
G alpha (12/13) signalling events 68 3.28e-02 9.19e-02 0.20800 0.183000 9.91e-02 8.97e-03 1.58e-01
Impaired BRCA2 binding to RAD51 35 1.08e-02 3.99e-02 0.20800 -0.111000 1.76e-01 2.57e-01 7.11e-02
Sphingolipid de novo biosynthesis 34 1.65e-01 2.87e-01 0.20800 0.089200 1.88e-01 3.68e-01 5.78e-02
Late endosomal microautophagy 30 2.31e-01 3.61e-01 0.20800 0.104000 1.80e-01 3.26e-01 8.77e-02
Signaling by NOTCH 173 4.96e-04 3.04e-03 0.20800 0.126000 1.65e-01 4.25e-03 1.79e-04
Ion transport by P-type ATPases 41 1.72e-01 2.98e-01 0.20800 0.154000 1.39e-01 8.71e-02 1.24e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.67e-02 1.18e-01 0.20800 -0.178000 1.07e-01 1.31e-01 3.65e-01
SHC1 events in ERBB2 signaling 17 2.66e-01 3.94e-01 0.20700 0.206000 2.26e-02 1.41e-01 8.72e-01
Synthesis of DNA 108 1.46e-06 1.90e-05 0.20700 -0.097600 1.83e-01 7.96e-02 1.04e-03
Signaling by Insulin receptor 63 3.62e-02 9.83e-02 0.20700 0.187000 8.77e-02 1.01e-02 2.29e-01
Signaling by TGFB family members 137 2.70e-03 1.32e-02 0.20600 0.128000 1.62e-01 9.76e-03 1.06e-03
Activation of the pre-replicative complex 32 1.57e-02 5.22e-02 0.20600 -0.162000 1.27e-01 1.12e-01 2.14e-01
Activation of kainate receptors upon glutamate binding 25 3.36e-01 4.69e-01 0.20600 0.124000 1.64e-01 2.82e-01 1.56e-01
SHC-mediated cascade:FGFR2 13 5.48e-01 6.52e-01 0.20600 0.109000 1.74e-01 4.95e-01 2.77e-01
Ca-dependent events 29 2.46e-01 3.73e-01 0.20500 0.179000 1.00e-01 9.45e-02 3.51e-01
Keratan sulfate degradation 9 4.99e-01 6.10e-01 0.20500 -0.020000 -2.04e-01 9.17e-01 2.89e-01
Collagen chain trimerization 26 3.16e-01 4.50e-01 0.20500 0.169000 1.17e-01 1.37e-01 3.03e-01
Synthesis of PIPs at the ER membrane 5 5.24e-01 6.33e-01 0.20500 -0.134000 1.55e-01 6.04e-01 5.48e-01
Germ layer formation at gastrulation 9 4.97e-01 6.08e-01 0.20500 0.018000 2.04e-01 9.26e-01 2.89e-01
Interleukin-18 signaling 6 7.38e-01 8.08e-01 0.20500 0.184000 9.01e-02 4.36e-01 7.02e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 3.70e-01 5.02e-01 0.20400 0.186000 8.38e-02 1.60e-01 5.27e-01
Trafficking of AMPA receptors 19 3.70e-01 5.02e-01 0.20400 0.186000 8.38e-02 1.60e-01 5.27e-01
Chondroitin sulfate/dermatan sulfate metabolism 37 2.05e-02 6.36e-02 0.20400 0.048400 -1.98e-01 6.10e-01 3.68e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.63e-01 3.91e-01 0.20300 -0.192000 6.74e-02 2.50e-01 6.86e-01
Deadenylation of mRNA 22 6.20e-02 1.44e-01 0.20300 -0.127000 1.58e-01 3.02e-01 1.98e-01
PI3K events in ERBB2 signaling 11 2.54e-01 3.83e-01 0.20300 0.167000 -1.16e-01 3.38e-01 5.07e-01
Calnexin/calreticulin cycle 26 2.16e-01 3.42e-01 0.20300 0.061700 1.93e-01 5.86e-01 8.77e-02
SHC-mediated cascade:FGFR4 11 6.38e-01 7.28e-01 0.20300 0.137000 1.49e-01 4.31e-01 3.91e-01
Asymmetric localization of PCP proteins 49 4.11e-02 1.07e-01 0.20200 0.044300 1.98e-01 5.92e-01 1.67e-02
Signaling by MST1 5 8.11e-01 8.66e-01 0.20200 -0.161000 -1.22e-01 5.33e-01 6.37e-01
Glycosphingolipid transport 7 6.77e-01 7.57e-01 0.20200 -0.190000 -6.85e-02 3.84e-01 7.54e-01
Oxidative Stress Induced Senescence 77 4.11e-02 1.07e-01 0.20200 0.124000 1.59e-01 5.94e-02 1.58e-02
Coenzyme A biosynthesis 7 4.58e-01 5.74e-01 0.20200 -0.188000 7.19e-02 3.88e-01 7.42e-01
Membrane binding and targetting of GAG proteins 13 2.15e-01 3.42e-01 0.20200 -0.094200 1.78e-01 5.56e-01 2.66e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 2.15e-01 3.42e-01 0.20200 -0.094200 1.78e-01 5.56e-01 2.66e-01
Downstream signaling of activated FGFR1 22 3.66e-01 4.97e-01 0.20100 0.174000 1.01e-01 1.57e-01 4.13e-01
RAC1 GTPase cycle 170 1.60e-04 1.19e-03 0.20100 0.185000 7.95e-02 3.17e-05 7.39e-02
Hedgehog ‘off’ state 91 6.38e-03 2.57e-02 0.20100 0.067100 1.90e-01 2.68e-01 1.78e-03
Maturation of nucleoprotein 9683610 11 4.67e-01 5.83e-01 0.20100 0.031500 1.98e-01 8.57e-01 2.54e-01
Activation of ATR in response to replication stress 37 1.02e-02 3.79e-02 0.20000 -0.138000 1.45e-01 1.45e-01 1.27e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 4.58e-02 1.16e-01 0.20000 -0.198000 -2.82e-02 2.27e-02 7.46e-01
Diseases associated with surfactant metabolism 5 7.36e-01 8.07e-01 0.20000 0.194000 5.10e-02 4.53e-01 8.44e-01
Nef Mediated CD8 Down-regulation 7 7.09e-01 7.82e-01 0.20000 0.181000 8.61e-02 4.07e-01 6.93e-01
PCP/CE pathway 74 3.18e-02 8.98e-02 0.20000 0.094700 1.76e-01 1.59e-01 8.66e-03
Advanced glycosylation endproduct receptor signaling 12 3.58e-01 4.90e-01 0.20000 -0.009540 2.00e-01 9.54e-01 2.31e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 5.58e-02 1.34e-01 0.19900 0.190000 6.09e-02 1.91e-02 4.52e-01
Sphingolipid catabolism 11 4.37e-01 5.56e-01 0.19900 0.199000 1.35e-02 2.54e-01 9.38e-01
FLT3 signaling by CBL mutants 7 6.15e-01 7.07e-01 0.19900 -0.197000 -2.74e-02 3.67e-01 9.00e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 5.27e-01 6.35e-01 0.19900 0.069000 1.86e-01 6.79e-01 2.64e-01
PPARA activates gene expression 105 1.70e-02 5.54e-02 0.19800 0.141000 1.40e-01 1.27e-02 1.32e-02
Defective B3GAT3 causes JDSSDHD 10 3.13e-01 4.48e-01 0.19800 0.170000 -1.02e-01 3.52e-01 5.78e-01
RHO GTPase cycle 408 1.25e-07 1.99e-06 0.19800 0.154000 1.25e-01 1.00e-07 1.51e-05
Meiosis 66 4.87e-03 2.08e-02 0.19800 -0.003000 1.98e-01 9.66e-01 5.51e-03
Signaling by FGFR4 32 2.66e-01 3.94e-01 0.19700 0.111000 1.63e-01 2.77e-01 1.10e-01
Circadian Clock 67 8.29e-03 3.20e-02 0.19700 0.196000 1.86e-02 5.42e-03 7.92e-01
Inhibition of DNA recombination at telomere 33 3.12e-02 8.86e-02 0.19700 -0.066400 1.86e-01 5.09e-01 6.49e-02
Neurotoxicity of clostridium toxins 9 4.75e-01 5.89e-01 0.19700 0.008980 -1.97e-01 9.63e-01 3.07e-01
G2/M DNA damage checkpoint 66 2.16e-02 6.62e-02 0.19700 0.051600 1.90e-01 4.69e-01 7.71e-03
Negative regulation of the PI3K/AKT network 91 5.55e-03 2.28e-02 0.19600 0.189000 5.35e-02 1.86e-03 3.77e-01
Chaperonin-mediated protein folding 77 3.82e-02 1.02e-01 0.19600 0.102000 1.67e-01 1.21e-01 1.11e-02
Glycerophospholipid catabolism 6 7.71e-01 8.35e-01 0.19600 -0.170000 -9.85e-02 4.72e-01 6.76e-01
CRMPs in Sema3A signaling 13 5.65e-01 6.65e-01 0.19600 0.171000 9.64e-02 2.86e-01 5.47e-01
Platelet Aggregation (Plug Formation) 28 2.42e-01 3.70e-01 0.19600 0.182000 7.22e-02 9.53e-02 5.09e-01
IKK complex recruitment mediated by RIP1 23 2.53e-01 3.82e-01 0.19600 0.046200 1.90e-01 7.01e-01 1.14e-01
HIV Transcription Initiation 45 5.07e-03 2.13e-02 0.19500 -0.128000 1.48e-01 1.38e-01 8.60e-02
RNA Polymerase II HIV Promoter Escape 45 5.07e-03 2.13e-02 0.19500 -0.128000 1.48e-01 1.38e-01 8.60e-02
RNA Polymerase II Promoter Escape 45 5.07e-03 2.13e-02 0.19500 -0.128000 1.48e-01 1.38e-01 8.60e-02
RNA Polymerase II Transcription Initiation 45 5.07e-03 2.13e-02 0.19500 -0.128000 1.48e-01 1.38e-01 8.60e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 5.07e-03 2.13e-02 0.19500 -0.128000 1.48e-01 1.38e-01 8.60e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 5.07e-03 2.13e-02 0.19500 -0.128000 1.48e-01 1.38e-01 8.60e-02
RHOH GTPase cycle 33 2.39e-01 3.69e-01 0.19500 0.096600 1.70e-01 3.37e-01 9.12e-02
Cell Cycle 609 1.53e-19 8.16e-18 0.19500 0.011800 1.95e-01 6.19e-01 1.97e-16
mRNA Capping 29 9.12e-02 1.91e-01 0.19500 -0.195000 1.20e-02 6.93e-02 9.11e-01
Downstream TCR signaling 89 3.60e-04 2.39e-03 0.19500 -0.029100 1.93e-01 6.35e-01 1.66e-03
Alpha-protein kinase 1 signaling pathway 11 5.39e-01 6.46e-01 0.19500 0.054500 1.87e-01 7.54e-01 2.82e-01
Signaling by TGF-beta Receptor Complex 90 2.66e-02 7.74e-02 0.19500 0.109000 1.61e-01 7.38e-02 8.11e-03
Noncanonical activation of NOTCH3 8 5.84e-01 6.80e-01 0.19500 0.024900 1.93e-01 9.03e-01 3.44e-01
Non-integrin membrane-ECM interactions 46 6.88e-03 2.74e-02 0.19400 0.174000 -8.61e-02 4.11e-02 3.12e-01
Downregulation of ERBB2 signaling 24 3.93e-01 5.18e-01 0.19400 -0.115000 -1.56e-01 3.31e-01 1.85e-01
Immune System 1828 6.39e-31 1.23e-28 0.19400 0.101000 1.65e-01 9.26e-13 1.01e-31
Extension of Telomeres 51 8.77e-03 3.35e-02 0.19400 -0.189000 4.19e-02 1.95e-02 6.05e-01
G alpha (q) signalling events 139 1.51e-03 8.14e-03 0.19300 0.177000 7.92e-02 3.26e-04 1.07e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 5.17e-01 6.27e-01 0.19300 -0.168000 9.55e-02 4.76e-01 6.85e-01
TGFBR1 KD Mutants in Cancer 6 5.17e-01 6.27e-01 0.19300 -0.168000 9.55e-02 4.76e-01 6.85e-01
Diseases of signal transduction by growth factor receptors and second messengers 399 4.27e-07 6.17e-06 0.19300 0.125000 1.47e-01 1.88e-05 4.46e-07
Signaling by ERBB2 KD Mutants 20 3.37e-01 4.70e-01 0.19300 0.185000 5.51e-02 1.53e-01 6.70e-01
RUNX3 Regulates Immune Response and Cell Migration 5 7.96e-01 8.57e-01 0.19200 0.081700 1.74e-01 7.52e-01 5.00e-01
Regulated Necrosis 55 1.74e-02 5.63e-02 0.19200 0.003880 1.92e-01 9.60e-01 1.36e-02
Phenylalanine and tyrosine metabolism 9 5.68e-01 6.67e-01 0.19200 -0.190000 -3.14e-02 3.25e-01 8.71e-01
NrCAM interactions 6 7.97e-01 8.57e-01 0.19200 -0.153000 -1.16e-01 5.18e-01 6.22e-01
HIV elongation arrest and recovery 32 1.60e-01 2.84e-01 0.19200 -0.186000 -4.49e-02 6.82e-02 6.60e-01
Pausing and recovery of HIV elongation 32 1.60e-01 2.84e-01 0.19200 -0.186000 -4.49e-02 6.82e-02 6.60e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 10 3.49e-01 4.84e-01 0.19100 0.171000 -8.50e-02 3.48e-01 6.42e-01
G beta:gamma signalling through PLC beta 17 5.35e-01 6.42e-01 0.19100 0.122000 1.47e-01 3.84e-01 2.94e-01
Presynaptic function of Kainate receptors 17 5.35e-01 6.42e-01 0.19100 0.122000 1.47e-01 3.84e-01 2.94e-01
Peroxisomal protein import 58 2.45e-03 1.22e-02 0.19100 -0.172000 8.18e-02 2.32e-02 2.81e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 3.91e-01 5.17e-01 0.19100 0.188000 2.90e-02 2.07e-01 8.46e-01
Signaling by Hedgehog 120 4.13e-03 1.85e-02 0.19000 0.075900 1.74e-01 1.51e-01 9.68e-04
Signaling by BMP 23 4.31e-01 5.51e-01 0.19000 0.119000 1.48e-01 3.21e-01 2.20e-01
tRNA Aminoacylation 42 3.32e-02 9.26e-02 0.19000 -0.189000 1.90e-02 3.40e-02 8.31e-01
Lipophagy 7 5.15e-01 6.25e-01 0.19000 -0.056400 1.81e-01 7.96e-01 4.06e-01
Processing of Intronless Pre-mRNAs 20 2.40e-01 3.70e-01 0.19000 -0.190000 -5.08e-03 1.42e-01 9.69e-01
GPCR ligand binding 241 4.50e-07 6.35e-06 0.19000 0.187000 3.06e-02 5.63e-07 4.13e-01
Ribavirin ADME 11 6.39e-01 7.29e-01 0.19000 0.094400 1.64e-01 5.88e-01 3.45e-01
Extra-nuclear estrogen signaling 65 7.62e-02 1.67e-01 0.18900 0.162000 9.86e-02 2.41e-02 1.69e-01
HDL assembly 6 6.43e-01 7.31e-01 0.18900 0.189000 -1.47e-03 4.22e-01 9.95e-01
FGFR2 ligand binding and activation 9 6.48e-01 7.35e-01 0.18900 -0.177000 -6.66e-02 3.57e-01 7.29e-01
Interleukin-1 signaling 99 2.59e-02 7.59e-02 0.18900 0.113000 1.52e-01 5.28e-02 8.97e-03
Bile acid and bile salt metabolism 28 2.89e-01 4.20e-01 0.18900 0.079400 1.72e-01 4.67e-01 1.16e-01
Lysine catabolism 10 7.02e-01 7.78e-01 0.18900 0.132000 1.35e-01 4.70e-01 4.59e-01
Neurotransmitter receptors and postsynaptic signal transmission 132 6.66e-03 2.66e-02 0.18900 0.157000 1.05e-01 1.83e-03 3.77e-02
Signaling by FGFR2 IIIa TM 18 2.26e-01 3.55e-01 0.18900 -0.187000 2.54e-02 1.69e-01 8.52e-01
ERBB2 Regulates Cell Motility 10 4.87e-01 5.99e-01 0.18900 -0.001370 -1.89e-01 9.94e-01 3.02e-01
C-type lectin receptors (CLRs) 116 3.76e-03 1.71e-02 0.18800 0.063700 1.77e-01 2.36e-01 1.01e-03
Maternal to zygotic transition (MZT) 71 8.37e-02 1.79e-01 0.18800 0.127000 1.38e-01 6.43e-02 4.39e-02
The NLRP3 inflammasome 16 3.05e-01 4.39e-01 0.18700 0.007230 -1.87e-01 9.60e-01 1.95e-01
Regulation of NF-kappa B signaling 18 2.57e-01 3.85e-01 0.18700 -0.186000 1.14e-02 1.71e-01 9.33e-01
tRNA processing in the mitochondrion 24 4.38e-01 5.56e-01 0.18600 -0.131000 -1.33e-01 2.68e-01 2.59e-01
Deubiquitination 225 1.60e-04 1.19e-03 0.18600 0.092700 1.61e-01 1.66e-02 3.04e-05
Adaptive Immune System 765 1.21e-16 5.39e-15 0.18600 0.056100 1.77e-01 8.32e-03 7.31e-17
HDR through MMEJ (alt-NHEJ) 12 2.82e-01 4.13e-01 0.18600 -0.115000 1.46e-01 4.92e-01 3.81e-01
RHOQ GTPase cycle 54 6.64e-02 1.52e-01 0.18500 0.178000 5.26e-02 2.40e-02 5.04e-01
Receptor-type tyrosine-protein phosphatases 11 3.58e-01 4.90e-01 0.18500 0.065600 -1.73e-01 7.07e-01 3.21e-01
Toll-like Receptor Cascades 162 3.90e-03 1.76e-02 0.18500 0.117000 1.43e-01 1.01e-02 1.70e-03
AURKA Activation by TPX2 72 3.20e-02 9.01e-02 0.18500 0.058500 1.75e-01 3.91e-01 1.02e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 7.80e-01 8.44e-01 0.18500 0.150000 1.08e-01 4.93e-01 6.21e-01
O-linked glycosylation 81 9.94e-03 3.74e-02 0.18400 0.182000 3.22e-02 4.71e-03 6.16e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 8.17e-01 8.70e-01 0.18400 -0.134000 -1.26e-01 5.69e-01 5.92e-01
Signaling by NOTCH3 42 1.43e-01 2.64e-01 0.18400 0.173000 6.27e-02 5.21e-02 4.82e-01
CLEC7A (Dectin-1) signaling 85 1.19e-02 4.31e-02 0.18400 0.045000 1.79e-01 4.74e-01 4.42e-03
G alpha (i) signalling events 196 1.47e-04 1.10e-03 0.18400 0.172000 6.58e-02 3.30e-05 1.12e-01
O-glycosylation of TSR domain-containing proteins 25 2.15e-01 3.42e-01 0.18400 -0.019400 -1.83e-01 8.66e-01 1.13e-01
Defective B4GALT7 causes EDS, progeroid type 10 3.52e-01 4.88e-01 0.18400 0.135000 -1.25e-01 4.60e-01 4.94e-01
Nonhomologous End-Joining (NHEJ) 40 8.75e-02 1.86e-01 0.18300 0.019800 1.82e-01 8.28e-01 4.61e-02
RAC3 GTPase cycle 86 4.91e-02 1.21e-01 0.18200 0.150000 1.03e-01 1.61e-02 9.76e-02
DAP12 interactions 39 2.78e-01 4.09e-01 0.18200 0.125000 1.32e-01 1.76e-01 1.53e-01
Protein folding 83 3.39e-02 9.34e-02 0.18200 0.077000 1.65e-01 2.25e-01 9.37e-03
Toll Like Receptor 4 (TLR4) Cascade 138 1.13e-02 4.14e-02 0.18200 0.129000 1.27e-01 8.67e-03 9.76e-03
Elastic fibre formation 33 9.07e-02 1.91e-01 0.18100 0.181000 -1.51e-02 7.24e-02 8.80e-01
MHC class II antigen presentation 113 2.22e-02 6.77e-02 0.18100 0.109000 1.45e-01 4.56e-02 7.80e-03
Attachment of GPI anchor to uPAR 7 7.93e-01 8.54e-01 0.18100 0.141000 1.13e-01 5.18e-01 6.04e-01
PI3K/AKT Signaling in Cancer 83 1.36e-03 7.42e-03 0.18100 0.177000 -3.58e-02 5.33e-03 5.73e-01
CDH11 homotypic and heterotypic interactions 5 6.41e-01 7.29e-01 0.18100 0.063100 -1.69e-01 8.07e-01 5.13e-01
Sensory Perception 188 1.89e-05 1.90e-04 0.18000 0.179000 2.12e-02 2.30e-05 6.17e-01
Myoclonic epilepsy of Lafora 8 4.67e-01 5.83e-01 0.18000 -0.157000 8.79e-02 4.42e-01 6.67e-01
Activation of RAC1 downstream of NMDARs 7 6.52e-01 7.35e-01 0.18000 0.180000 1.32e-02 4.11e-01 9.52e-01
Syndecan interactions 23 1.34e-01 2.52e-01 0.18000 0.169000 -6.06e-02 1.60e-01 6.15e-01
MicroRNA (miRNA) biogenesis 24 3.18e-01 4.50e-01 0.18000 -0.173000 -4.94e-02 1.43e-01 6.75e-01
Chromosome Maintenance 102 4.72e-05 4.14e-04 0.17900 -0.143000 1.08e-01 1.23e-02 6.01e-02
Antiviral mechanism by IFN-stimulated genes 140 4.13e-06 4.87e-05 0.17900 -0.067300 1.66e-01 1.69e-01 6.87e-04
TP53 Regulates Transcription of Cell Cycle Genes 47 2.12e-01 3.40e-01 0.17900 0.143000 1.08e-01 9.00e-02 2.01e-01
Regulation of PLK1 Activity at G2/M Transition 87 6.62e-03 2.65e-02 0.17900 0.020000 1.78e-01 7.47e-01 4.13e-03
DCC mediated attractive signaling 13 6.60e-01 7.43e-01 0.17900 0.119000 1.33e-01 4.56e-01 4.05e-01
Regulation of lipid metabolism by PPARalpha 107 3.42e-02 9.40e-02 0.17900 0.128000 1.25e-01 2.27e-02 2.50e-02
Signaling by Nuclear Receptors 210 1.35e-03 7.35e-03 0.17900 0.133000 1.19e-01 9.09e-04 2.85e-03
RIP-mediated NFkB activation via ZBP1 17 2.65e-01 3.94e-01 0.17900 0.175000 -3.57e-02 2.12e-01 7.99e-01
Class B/2 (Secretin family receptors) 54 1.58e-01 2.83e-01 0.17900 0.149000 9.83e-02 5.82e-02 2.11e-01
RIPK1-mediated regulated necrosis 31 1.77e-01 3.02e-01 0.17800 0.024100 1.77e-01 8.16e-01 8.84e-02
Regulation of necroptotic cell death 31 1.77e-01 3.02e-01 0.17800 0.024100 1.77e-01 8.16e-01 8.84e-02
CDC42 GTPase cycle 139 1.97e-04 1.40e-03 0.17700 0.177000 6.70e-03 3.06e-04 8.92e-01
Vitamin B5 (pantothenate) metabolism 20 4.92e-01 6.04e-01 0.17700 0.089200 1.53e-01 4.90e-01 2.35e-01
HSF1-dependent transactivation 28 1.31e-01 2.47e-01 0.17700 0.175000 -2.37e-02 1.08e-01 8.28e-01
Cleavage of the damaged pyrimidine 26 1.64e-01 2.87e-01 0.17700 -0.015600 1.76e-01 8.91e-01 1.20e-01
Depyrimidination 26 1.64e-01 2.87e-01 0.17700 -0.015600 1.76e-01 8.91e-01 1.20e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 1.64e-01 2.87e-01 0.17700 -0.015600 1.76e-01 8.91e-01 1.20e-01
Signal Transduction 2034 5.55e-27 5.61e-25 0.17700 0.144000 1.02e-01 8.48e-27 2.57e-14
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 2.84e-01 4.15e-01 0.17700 0.112000 1.36e-01 2.18e-01 1.36e-01
Signaling by RAS mutants 40 2.84e-01 4.15e-01 0.17700 0.112000 1.36e-01 2.18e-01 1.36e-01
Signaling by moderate kinase activity BRAF mutants 40 2.84e-01 4.15e-01 0.17700 0.112000 1.36e-01 2.18e-01 1.36e-01
Signaling downstream of RAS mutants 40 2.84e-01 4.15e-01 0.17700 0.112000 1.36e-01 2.18e-01 1.36e-01
Receptor Mediated Mitophagy 11 5.55e-01 6.57e-01 0.17600 0.026300 1.74e-01 8.80e-01 3.18e-01
PI5P Regulates TP53 Acetylation 8 4.69e-01 5.85e-01 0.17500 0.131000 -1.17e-01 5.22e-01 5.67e-01
Suppression of phagosomal maturation 12 3.51e-01 4.87e-01 0.17500 -0.073500 1.59e-01 6.60e-01 3.40e-01
Signaling by Receptor Tyrosine Kinases 443 2.36e-07 3.54e-06 0.17400 0.153000 8.36e-02 3.38e-08 2.56e-03
Phosphorylation of the APC/C 20 1.58e-01 2.83e-01 0.17400 -0.140000 1.03e-01 2.77e-01 4.25e-01
Bacterial Infection Pathways 65 1.43e-01 2.65e-01 0.17400 0.124000 1.22e-01 8.47e-02 8.80e-02
Interconversion of nucleotide di- and triphosphates 27 8.43e-02 1.80e-01 0.17400 -0.141000 1.01e-01 2.04e-01 3.62e-01
Nicotinate metabolism 26 3.24e-01 4.57e-01 0.17400 0.052300 1.66e-01 6.44e-01 1.43e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 4.31e-01 5.51e-01 0.17300 0.086700 1.50e-01 4.53e-01 1.96e-01
Deactivation of the beta-catenin transactivating complex 36 2.28e-01 3.58e-01 0.17200 0.056800 1.63e-01 5.56e-01 9.14e-02
Cell recruitment (pro-inflammatory response) 25 1.87e-01 3.13e-01 0.17200 0.019100 -1.71e-01 8.69e-01 1.39e-01
Purinergic signaling in leishmaniasis infection 25 1.87e-01 3.13e-01 0.17200 0.019100 -1.71e-01 8.69e-01 1.39e-01
Response of Mtb to phagocytosis 22 4.54e-01 5.70e-01 0.17200 0.074900 1.55e-01 5.43e-01 2.09e-01
Glycogen metabolism 21 3.78e-01 5.05e-01 0.17200 0.039000 1.67e-01 7.57e-01 1.85e-01
Ion channel transport 136 5.44e-03 2.25e-02 0.17100 0.159000 6.37e-02 1.37e-03 2.00e-01
Defective RIPK1-mediated regulated necrosis 7 5.64e-01 6.63e-01 0.17100 -0.157000 6.74e-02 4.71e-01 7.57e-01
Surfactant metabolism 20 5.62e-01 6.63e-01 0.17100 0.121000 1.21e-01 3.49e-01 3.51e-01
HDR through Homologous Recombination (HRR) 68 3.90e-03 1.76e-02 0.17100 -0.157000 6.81e-02 2.56e-02 3.32e-01
Transcriptional regulation by RUNX2 87 3.75e-02 1.01e-01 0.17000 0.064100 1.58e-01 3.02e-01 1.10e-02
Negative regulation of FGFR2 signaling 24 3.97e-01 5.21e-01 0.17000 0.061200 1.59e-01 6.04e-01 1.79e-01
Activation of BH3-only proteins 29 4.28e-01 5.48e-01 0.17000 -0.106000 -1.33e-01 3.25e-01 2.15e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 3.33e-02 9.26e-02 0.16900 0.104000 1.33e-01 5.18e-02 1.27e-02
Metabolism of cofactors 25 2.91e-01 4.22e-01 0.16900 -0.167000 -2.45e-02 1.49e-01 8.32e-01
Infection with Mycobacterium tuberculosis 26 3.83e-01 5.09e-01 0.16900 0.064300 1.56e-01 5.70e-01 1.69e-01
ZBP1(DAI) mediated induction of type I IFNs 20 2.52e-01 3.81e-01 0.16800 0.165000 -3.20e-02 2.00e-01 8.05e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 41 1.75e-01 3.02e-01 0.16800 0.044700 1.62e-01 6.21e-01 7.21e-02
HDR through Single Strand Annealing (SSA) 37 3.94e-02 1.04e-01 0.16800 -0.121000 1.17e-01 2.04e-01 2.17e-01
Regulation of TP53 Activity through Acetylation 29 3.44e-01 4.78e-01 0.16800 -0.063900 -1.56e-01 5.51e-01 1.47e-01
G beta:gamma signalling through PI3Kgamma 22 5.40e-01 6.46e-01 0.16800 0.114000 1.23e-01 3.55e-01 3.16e-01
Diseases of carbohydrate metabolism 29 4.48e-01 5.64e-01 0.16700 -0.119000 -1.17e-01 2.66e-01 2.74e-01
Interferon Signaling 237 7.47e-09 1.39e-07 0.16700 -0.071100 1.52e-01 5.95e-02 5.85e-05
Negative regulation of FGFR3 signaling 21 4.88e-01 6.00e-01 0.16700 0.072200 1.51e-01 5.67e-01 2.31e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.42e-01 2.63e-01 0.16700 0.002820 1.67e-01 9.77e-01 8.74e-02
Regulation of localization of FOXO transcription factors 11 4.13e-01 5.36e-01 0.16700 0.076200 -1.48e-01 6.61e-01 3.95e-01
G-protein mediated events 43 1.80e-01 3.05e-01 0.16700 0.159000 4.99e-02 7.12e-02 5.72e-01
Heme signaling 45 1.39e-01 2.58e-01 0.16700 0.162000 3.71e-02 5.96e-02 6.67e-01
IRE1alpha activates chaperones 46 1.59e-01 2.83e-01 0.16600 0.159000 4.91e-02 6.20e-02 5.64e-01
The canonical retinoid cycle in rods (twilight vision) 9 5.27e-01 6.35e-01 0.16600 0.045200 -1.60e-01 8.14e-01 4.07e-01
Transport of vitamins, nucleosides, and related molecules 31 4.22e-01 5.44e-01 0.16500 -0.130000 -1.01e-01 2.09e-01 3.29e-01
SARS-CoV-1 Infection 137 2.18e-05 2.13e-04 0.16500 -0.147000 7.52e-02 2.98e-03 1.28e-01
GPCR downstream signalling 396 5.27e-07 7.23e-06 0.16500 0.155000 5.63e-02 1.19e-07 5.45e-02
Signaling by NTRKs 116 2.70e-02 7.83e-02 0.16500 0.144000 7.95e-02 7.25e-03 1.39e-01
PI Metabolism 79 1.21e-01 2.34e-01 0.16500 0.114000 1.18e-01 7.86e-02 6.90e-02
Signaling by ERBB4 45 2.57e-01 3.85e-01 0.16500 0.142000 8.41e-02 1.01e-01 3.29e-01
Aggrephagy 34 3.97e-01 5.21e-01 0.16400 0.105000 1.26e-01 2.89e-01 2.02e-01
Stimuli-sensing channels 78 2.70e-02 7.83e-02 0.16400 0.162000 2.54e-02 1.31e-02 6.98e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.03e-02 6.33e-02 0.16400 -0.162000 2.70e-02 2.89e-02 7.15e-01
Oncogene Induced Senescence 33 3.85e-01 5.11e-01 0.16400 0.089900 1.37e-01 3.72e-01 1.73e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 6.51e-01 7.35e-01 0.16400 -0.020500 -1.63e-01 9.15e-01 3.98e-01
DNA Repair 288 1.13e-09 2.39e-08 0.16400 -0.155000 5.44e-02 6.40e-06 1.12e-01
Transcriptional regulation of white adipocyte differentiation 77 1.11e-01 2.18e-01 0.16400 0.136000 9.10e-02 3.89e-02 1.67e-01
Glycosphingolipid catabolism 31 4.17e-01 5.39e-01 0.16400 -0.134000 -9.35e-02 1.95e-01 3.68e-01
Cytokine Signaling in Immune system 662 1.12e-08 2.02e-07 0.16300 0.091300 1.36e-01 6.18e-05 2.68e-09
Ephrin signaling 17 3.75e-01 5.04e-01 0.16300 -0.009480 1.63e-01 9.46e-01 2.44e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 5.79e-01 6.77e-01 0.16300 0.159000 3.70e-02 3.21e-01 8.17e-01
NR1H2 and NR1H3-mediated signaling 38 1.39e-01 2.58e-01 0.16300 0.163000 6.15e-03 8.24e-02 9.48e-01
PRC2 methylates histones and DNA 27 3.09e-01 4.44e-01 0.16300 0.031400 1.60e-01 7.78e-01 1.51e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 1.43e-01 2.64e-01 0.16300 -0.153000 5.61e-02 1.69e-01 6.14e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.43e-01 2.64e-01 0.16300 -0.153000 5.61e-02 1.69e-01 6.14e-01
Signaling by GPCR 441 3.39e-08 6.03e-07 0.16300 0.157000 4.32e-02 1.61e-08 1.20e-01
Striated Muscle Contraction 25 4.96e-01 6.08e-01 0.16100 0.135000 8.80e-02 2.42e-01 4.46e-01
Negative regulation of FGFR4 signaling 22 5.01e-01 6.11e-01 0.16100 0.070800 1.45e-01 5.65e-01 2.40e-01
Clathrin-mediated endocytosis 127 3.67e-02 9.91e-02 0.16100 0.102000 1.24e-01 4.72e-02 1.54e-02
Downregulation of TGF-beta receptor signaling 26 4.38e-01 5.56e-01 0.16100 0.068800 1.45e-01 5.44e-01 2.00e-01
IL-6-type cytokine receptor ligand interactions 12 4.33e-01 5.52e-01 0.16100 0.054100 -1.51e-01 7.46e-01 3.64e-01
TNFR2 non-canonical NF-kB pathway 84 1.18e-02 4.27e-02 0.16100 -0.001540 1.61e-01 9.81e-01 1.10e-02
HIV Life Cycle 144 1.06e-04 8.38e-04 0.16000 -0.156000 3.51e-02 1.20e-03 4.67e-01
Telomere Maintenance 78 2.67e-03 1.31e-02 0.16000 -0.137000 8.35e-02 3.70e-02 2.02e-01
Class I MHC mediated antigen processing & presentation 343 3.02e-09 6.03e-08 0.16000 -0.017400 1.59e-01 5.80e-01 4.10e-07
Synthesis of pyrophosphates in the cytosol 8 5.73e-01 6.71e-01 0.16000 -0.150000 5.51e-02 4.62e-01 7.87e-01
LGI-ADAM interactions 9 6.88e-01 7.68e-01 0.16000 -0.032100 -1.57e-01 8.68e-01 4.16e-01
Bicarbonate transporters 9 5.70e-01 6.69e-01 0.16000 -0.031500 1.57e-01 8.70e-01 4.16e-01
Integrin signaling 22 5.53e-01 6.55e-01 0.16000 0.131000 9.09e-02 2.86e-01 4.61e-01
MET activates PTK2 signaling 21 5.43e-01 6.48e-01 0.15900 0.139000 7.82e-02 2.70e-01 5.35e-01
Azathioprine ADME 20 4.43e-01 5.60e-01 0.15900 0.033600 1.56e-01 7.95e-01 2.28e-01
Aryl hydrocarbon receptor signalling 6 7.44e-01 8.13e-01 0.15900 -0.159000 -7.28e-03 5.00e-01 9.75e-01
Signaling by ERBB2 TMD/JMD mutants 17 4.37e-01 5.56e-01 0.15900 0.159000 8.55e-03 2.57e-01 9.51e-01
CaM pathway 27 4.51e-01 5.66e-01 0.15900 0.140000 7.37e-02 2.07e-01 5.08e-01
Calmodulin induced events 27 4.51e-01 5.66e-01 0.15900 0.140000 7.37e-02 2.07e-01 5.08e-01
Cytochrome P450 - arranged by substrate type 33 2.62e-01 3.91e-01 0.15800 0.155000 3.17e-02 1.24e-01 7.53e-01
Defective pyroptosis 27 2.23e-01 3.52e-01 0.15800 -0.014200 1.57e-01 8.98e-01 1.57e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 7.99e-01 8.59e-01 0.15800 0.120000 1.03e-01 5.34e-01 5.92e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 6.65e-01 7.46e-01 0.15800 -0.023000 1.56e-01 9.16e-01 4.75e-01
Processing of DNA double-strand break ends 69 3.65e-02 9.88e-02 0.15800 0.007820 1.57e-01 9.11e-01 2.37e-02
Nuclear Pore Complex (NPC) Disassembly 36 2.55e-01 3.84e-01 0.15800 -0.153000 -3.97e-02 1.13e-01 6.80e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.07e-01 7.81e-01 0.15800 0.118000 1.05e-01 4.45e-01 4.98e-01
Androgen biosynthesis 5 8.32e-01 8.82e-01 0.15700 0.043100 1.51e-01 8.67e-01 5.58e-01
RAS processing 23 2.65e-01 3.94e-01 0.15700 -0.022100 1.56e-01 8.54e-01 1.96e-01
trans-Golgi Network Vesicle Budding 69 1.22e-01 2.35e-01 0.15700 0.066000 1.43e-01 3.43e-01 4.04e-02
SUMOylation of DNA damage response and repair proteins 77 2.85e-02 8.20e-02 0.15600 -0.156000 -1.04e-02 1.80e-02 8.75e-01
Diseases associated with N-glycosylation of proteins 20 5.64e-01 6.64e-01 0.15600 -0.138000 -7.28e-02 2.85e-01 5.73e-01
Serotonin Neurotransmitter Release Cycle 15 3.97e-01 5.21e-01 0.15500 0.150000 -3.90e-02 3.13e-01 7.94e-01
Other interleukin signaling 18 6.40e-01 7.29e-01 0.15500 0.091700 1.24e-01 5.01e-01 3.61e-01
Host Interactions of HIV factors 118 1.78e-04 1.30e-03 0.15500 -0.117000 1.01e-01 2.81e-02 5.84e-02
HIV Infection 213 1.87e-07 2.86e-06 0.15400 -0.100000 1.18e-01 1.18e-02 3.10e-03
Cytoprotection by HMOX1 53 2.02e-01 3.30e-01 0.15400 0.141000 6.17e-02 7.49e-02 4.37e-01
Defective B3GALTL causes PpS 24 2.95e-01 4.27e-01 0.15400 0.007820 -1.54e-01 9.47e-01 1.92e-01
Transcription of the HIV genome 67 1.04e-02 3.85e-02 0.15300 -0.136000 7.14e-02 5.46e-02 3.12e-01
ER Quality Control Compartment (ERQC) 21 3.62e-01 4.94e-01 0.15300 -0.001380 1.53e-01 9.91e-01 2.24e-01
Formation of the Editosome 6 7.51e-01 8.17e-01 0.15300 0.153000 -4.24e-04 5.17e-01 9.99e-01
mRNA Editing: C to U Conversion 6 7.51e-01 8.17e-01 0.15300 0.153000 -4.24e-04 5.17e-01 9.99e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 4.20e-01 5.43e-01 0.15300 0.055700 1.42e-01 6.10e-01 1.92e-01
Dermatan sulfate biosynthesis 6 6.50e-01 7.35e-01 0.15300 0.117000 -9.86e-02 6.21e-01 6.76e-01
PERK regulates gene expression 30 2.34e-01 3.64e-01 0.15300 -0.153000 3.35e-03 1.48e-01 9.75e-01
PLC beta mediated events 39 2.16e-01 3.42e-01 0.15200 0.150000 2.54e-02 1.04e-01 7.84e-01
Sensing of DNA Double Strand Breaks 6 6.51e-01 7.35e-01 0.15200 -0.112000 1.03e-01 6.36e-01 6.61e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 5.18e-01 6.27e-01 0.15200 -0.040300 -1.46e-01 7.61e-01 2.69e-01
Signaling by NTRK1 (TRKA) 102 7.20e-02 1.61e-01 0.15200 0.131000 7.63e-02 2.22e-02 1.83e-01
NCAM1 interactions 26 4.22e-01 5.44e-01 0.15000 -0.042400 -1.44e-01 7.08e-01 2.03e-01
Peroxisomal lipid metabolism 27 1.78e-01 3.03e-01 0.15000 -0.135000 6.43e-02 2.24e-01 5.63e-01
NRAGE signals death through JNK 52 1.26e-01 2.41e-01 0.15000 0.149000 1.84e-02 6.39e-02 8.18e-01
TBC/RABGAPs 45 3.67e-01 4.98e-01 0.15000 0.112000 9.87e-02 1.92e-01 2.52e-01
IFNG signaling activates MAPKs 8 8.21e-01 8.72e-01 0.14900 0.078100 1.27e-01 7.02e-01 5.33e-01
Toll Like Receptor 2 (TLR2) Cascade 109 9.09e-02 1.91e-01 0.14900 0.109000 1.02e-01 4.94e-02 6.58e-02
Toll Like Receptor TLR1:TLR2 Cascade 109 9.09e-02 1.91e-01 0.14900 0.109000 1.02e-01 4.94e-02 6.58e-02
Loss of Nlp from mitotic centrosomes 69 9.13e-02 1.91e-01 0.14900 0.034400 1.45e-01 6.21e-01 3.73e-02
Loss of proteins required for interphase microtubule organization from the centrosome 69 9.13e-02 1.91e-01 0.14900 0.034400 1.45e-01 6.21e-01 3.73e-02
CaMK IV-mediated phosphorylation of CREB 8 6.11e-01 7.05e-01 0.14900 -0.138000 5.65e-02 5.00e-01 7.82e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 5.53e-01 6.55e-01 0.14900 0.128000 7.60e-02 2.79e-01 5.19e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 3.15e-01 4.50e-01 0.14800 0.121000 8.54e-02 1.38e-01 2.96e-01
Assembly of collagen fibrils and other multimeric structures 41 1.45e-01 2.65e-01 0.14800 0.148000 -7.67e-03 1.01e-01 9.32e-01
TRAF6 mediated IRF7 activation 15 7.01e-01 7.77e-01 0.14800 0.079300 1.24e-01 5.95e-01 4.04e-01
Cellular Senescence 142 4.64e-02 1.17e-01 0.14700 0.095400 1.12e-01 4.96e-02 2.10e-02
Signaling by Activin 13 4.28e-01 5.48e-01 0.14700 -0.082900 1.22e-01 6.05e-01 4.48e-01
Neuronal System 262 5.18e-05 4.43e-04 0.14700 0.146000 1.97e-02 4.87e-05 5.84e-01
Assembly Of The HIV Virion 15 3.92e-01 5.17e-01 0.14700 -0.066500 1.31e-01 6.56e-01 3.79e-01
Neddylation 215 1.07e-06 1.44e-05 0.14700 -0.078600 1.24e-01 4.70e-02 1.70e-03
Acyl chain remodelling of PS 14 5.63e-01 6.63e-01 0.14600 0.146000 8.76e-03 3.44e-01 9.55e-01
MITF-M-regulated melanocyte development 110 9.62e-02 1.97e-01 0.14600 0.110000 9.66e-02 4.64e-02 8.00e-02
Notch-HLH transcription pathway 28 1.71e-01 2.95e-01 0.14600 0.074500 -1.26e-01 4.95e-01 2.49e-01
Chaperone Mediated Autophagy 20 6.53e-01 7.35e-01 0.14500 0.092100 1.12e-01 4.76e-01 3.84e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 3.24e-01 4.57e-01 0.14500 0.138000 4.59e-02 1.42e-01 6.24e-01
FGFR2b ligand binding and activation 6 7.21e-01 7.93e-01 0.14500 -0.140000 3.93e-02 5.53e-01 8.67e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 2.66e-01 3.94e-01 0.14500 -0.124000 -7.51e-02 1.06e-01 3.27e-01
Glycosaminoglycan metabolism 95 3.03e-02 8.63e-02 0.14500 0.143000 1.89e-02 1.58e-02 7.51e-01
Defective Intrinsic Pathway for Apoptosis 24 3.71e-01 5.02e-01 0.14400 -0.003890 -1.44e-01 9.74e-01 2.21e-01
Intraflagellar transport 47 4.91e-02 1.21e-01 0.14400 -0.108000 9.61e-02 2.01e-01 2.54e-01
RNA Polymerase II Pre-transcription Events 77 1.12e-02 4.10e-02 0.14400 -0.058000 1.32e-01 3.79e-01 4.51e-02
Transmission across Chemical Synapses 179 1.03e-02 3.81e-02 0.14400 0.131000 6.05e-02 2.52e-03 1.63e-01
TRAIL signaling 8 6.04e-01 6.98e-01 0.14400 -0.088200 1.13e-01 6.66e-01 5.79e-01
Collagen formation 63 1.34e-01 2.52e-01 0.14300 0.139000 3.35e-02 5.59e-02 6.46e-01
Insulin receptor signalling cascade 40 2.82e-01 4.13e-01 0.14300 0.139000 3.45e-02 1.28e-01 7.05e-01
Late Phase of HIV Life Cycle 131 9.76e-04 5.56e-03 0.14200 -0.135000 4.34e-02 7.68e-03 3.92e-01
Diseases associated with O-glycosylation of proteins 46 7.02e-02 1.57e-01 0.14200 0.126000 -6.42e-02 1.39e-01 4.51e-01
Intracellular signaling by second messengers 264 4.06e-03 1.83e-02 0.14100 0.116000 8.02e-02 1.15e-03 2.48e-02
IRAK2 mediated activation of TAK1 complex 10 5.48e-01 6.52e-01 0.14100 -0.081000 1.15e-01 6.57e-01 5.27e-01
PIP3 activates AKT signaling 232 9.24e-03 3.52e-02 0.14100 0.112000 8.55e-02 3.28e-03 2.49e-02
Diseases of mitotic cell cycle 38 1.78e-01 3.03e-01 0.14000 -0.018200 1.39e-01 8.46e-01 1.37e-01
Synthesis of GDP-mannose 6 8.47e-01 8.92e-01 0.14000 -0.044400 -1.33e-01 8.51e-01 5.73e-01
XBP1(S) activates chaperone genes 44 2.49e-01 3.76e-01 0.14000 0.137000 2.87e-02 1.16e-01 7.42e-01
RNA Polymerase I Promoter Clearance 64 1.27e-01 2.41e-01 0.14000 -0.137000 -2.62e-02 5.72e-02 7.17e-01
RNA Polymerase I Transcription 64 1.27e-01 2.41e-01 0.14000 -0.137000 -2.62e-02 5.72e-02 7.17e-01
Viral Infection Pathways 770 1.63e-19 8.45e-18 0.14000 -0.073800 1.19e-01 4.94e-04 2.20e-08
Synthesis of bile acids and bile salts 25 4.47e-01 5.64e-01 0.13900 0.025900 1.37e-01 8.23e-01 2.36e-01
Cleavage of the damaged purine 21 3.72e-01 5.02e-01 0.13900 -0.026200 1.37e-01 8.35e-01 2.78e-01
Depurination 21 3.72e-01 5.02e-01 0.13900 -0.026200 1.37e-01 8.35e-01 2.78e-01
Recognition and association of DNA glycosylase with site containing an affected purine 21 3.72e-01 5.02e-01 0.13900 -0.026200 1.37e-01 8.35e-01 2.78e-01
SUMOylation of DNA replication proteins 46 3.24e-01 4.57e-01 0.13900 -0.127000 -5.59e-02 1.35e-01 5.12e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.26e-01 2.41e-01 0.13900 0.103000 9.37e-02 6.49e-02 9.23e-02
Toll Like Receptor TLR6:TLR2 Cascade 108 1.26e-01 2.41e-01 0.13900 0.103000 9.37e-02 6.49e-02 9.23e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 5.83e-01 6.80e-01 0.13900 -0.138000 -1.97e-02 3.40e-01 8.91e-01
Eicosanoid ligand-binding receptors 13 6.43e-01 7.31e-01 0.13900 0.018900 1.38e-01 9.06e-01 3.90e-01
Mitochondrial RNA degradation 25 6.21e-01 7.12e-01 0.13900 -0.101000 -9.48e-02 3.81e-01 4.12e-01
Cytosolic tRNA aminoacylation 24 2.45e-01 3.72e-01 0.13800 -0.109000 8.57e-02 3.57e-01 4.67e-01
Selective autophagy 77 1.38e-02 4.76e-02 0.13800 -0.067700 1.20e-01 3.05e-01 6.86e-02
DAG and IP3 signaling 33 4.39e-01 5.56e-01 0.13700 0.128000 5.02e-02 2.04e-01 6.18e-01
Formation of WDR5-containing histone-modifying complexes 42 3.31e-01 4.64e-01 0.13700 -0.130000 -4.35e-02 1.46e-01 6.26e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 6.48e-01 7.35e-01 0.13700 0.040500 1.31e-01 7.79e-01 3.65e-01
TP53 Regulates Metabolic Genes 77 9.40e-02 1.95e-01 0.13700 0.025900 1.34e-01 6.94e-01 4.17e-02
Cell junction organization 77 1.96e-01 3.23e-01 0.13700 0.119000 6.77e-02 7.16e-02 3.05e-01
Heme biosynthesis 13 6.30e-01 7.20e-01 0.13600 -0.136000 -8.26e-03 3.96e-01 9.59e-01
Cilium Assembly 187 3.49e-05 3.21e-04 0.13600 -0.072100 1.16e-01 8.89e-02 6.45e-03
Plasma lipoprotein assembly, remodeling, and clearance 56 5.80e-02 1.37e-01 0.13600 0.127000 -4.96e-02 1.01e-01 5.21e-01
RAF-independent MAPK1/3 activation 21 3.03e-01 4.38e-01 0.13600 0.102000 -8.95e-02 4.17e-01 4.78e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 3.63e-06 4.35e-05 0.13600 -0.031100 1.32e-01 3.74e-01 1.66e-04
Zinc transporters 12 8.02e-01 8.61e-01 0.13500 0.086700 1.04e-01 6.03e-01 5.33e-01
Regulation of FOXO transcriptional activity by acetylation 10 6.08e-01 7.02e-01 0.13500 0.127000 -4.71e-02 4.88e-01 7.96e-01
TP53 Regulates Transcription of Cell Death Genes 42 2.08e-01 3.35e-01 0.13500 0.001100 -1.35e-01 9.90e-01 1.30e-01
Base-Excision Repair, AP Site Formation 28 2.33e-01 3.63e-01 0.13400 -0.060400 1.20e-01 5.80e-01 2.71e-01
Synthesis of PG 8 8.67e-01 9.07e-01 0.13300 -0.101000 -8.71e-02 6.21e-01 6.70e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 1.88e-01 3.15e-01 0.13300 -0.050200 1.23e-01 6.12e-01 2.13e-01
Miscellaneous transport and binding events 20 6.96e-01 7.74e-01 0.13300 0.105000 8.15e-02 4.15e-01 5.28e-01
SUMOylation of intracellular receptors 26 2.53e-01 3.82e-01 0.13300 0.113000 -7.09e-02 3.20e-01 5.32e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 7.07e-01 7.82e-01 0.13300 0.122000 -5.31e-02 5.78e-01 8.08e-01
Pregnenolone biosynthesis 10 8.35e-01 8.83e-01 0.13200 -0.080700 -1.05e-01 6.59e-01 5.65e-01
Infectious disease 951 1.36e-16 5.92e-15 0.13200 -0.016000 1.31e-01 4.02e-01 6.86e-12
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 7.93e-01 8.54e-01 0.13200 0.008550 1.32e-01 9.69e-01 5.46e-01
Nucleotide salvage 21 6.35e-01 7.25e-01 0.13200 0.055500 1.20e-01 6.60e-01 3.42e-01
Heparan sulfate/heparin (HS-GAG) metabolism 39 4.33e-01 5.52e-01 0.13200 -0.055800 -1.20e-01 5.46e-01 1.96e-01
Synthesis of IP3 and IP4 in the cytosol 22 3.10e-01 4.45e-01 0.13200 0.098800 -8.69e-02 4.23e-01 4.80e-01
Reproduction 84 1.03e-01 2.09e-01 0.13100 0.029100 1.28e-01 6.45e-01 4.31e-02
Mitotic Prophase 96 5.53e-02 1.33e-01 0.13100 0.016700 1.30e-01 7.77e-01 2.82e-02
Macroautophagy 128 1.27e-03 6.94e-03 0.13000 -0.094200 9.00e-02 6.58e-02 7.87e-02
CTLA4 inhibitory signaling 21 3.95e-01 5.19e-01 0.13000 -0.037200 1.25e-01 7.68e-01 3.22e-01
Activation of PUMA and translocation to mitochondria 8 7.94e-01 8.55e-01 0.13000 -0.021000 -1.28e-01 9.18e-01 5.29e-01
STING mediated induction of host immune responses 15 7.41e-01 8.10e-01 0.13000 -0.116000 -5.94e-02 4.38e-01 6.90e-01
Diseases associated with the TLR signaling cascade 29 5.93e-01 6.88e-01 0.13000 0.108000 7.15e-02 3.13e-01 5.05e-01
Diseases of Immune System 29 5.93e-01 6.88e-01 0.13000 0.108000 7.15e-02 3.13e-01 5.05e-01
Activation of the phototransduction cascade 8 8.72e-01 9.10e-01 0.12900 0.102000 7.91e-02 6.16e-01 6.99e-01
PTEN Regulation 126 5.34e-02 1.29e-01 0.12900 0.041500 1.22e-01 4.21e-01 1.77e-02
Toll Like Receptor 3 (TLR3) Cascade 104 1.81e-01 3.06e-01 0.12900 0.091600 9.10e-02 1.07e-01 1.09e-01
Assembly and cell surface presentation of NMDA receptors 30 2.30e-01 3.59e-01 0.12900 0.110000 -6.62e-02 2.96e-01 5.30e-01
Signaling by TGFBR3 39 5.01e-01 6.11e-01 0.12900 0.070600 1.07e-01 4.46e-01 2.46e-01
IRS-related events triggered by IGF1R 36 3.73e-01 5.03e-01 0.12800 0.126000 2.34e-02 1.90e-01 8.08e-01
Dopamine Neurotransmitter Release Cycle 20 3.63e-01 4.95e-01 0.12800 0.096500 -8.45e-02 4.55e-01 5.13e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 4.34e-01 5.53e-01 0.12800 0.125000 2.82e-02 2.21e-01 7.82e-01
Ovarian tumor domain proteases 37 5.11e-01 6.22e-01 0.12800 0.109000 6.60e-02 2.49e-01 4.87e-01
Transcriptional regulation by RUNX3 80 2.79e-01 4.10e-01 0.12700 0.093300 8.61e-02 1.49e-01 1.83e-01
Neurexins and neuroligins 35 3.57e-01 4.90e-01 0.12700 -0.012500 -1.26e-01 8.98e-01 1.96e-01
SARS-CoV Infections 428 1.17e-07 1.89e-06 0.12600 -0.022000 1.24e-01 4.36e-01 1.10e-05
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 5.36e-01 6.42e-01 0.12600 0.046700 1.17e-01 6.58e-01 2.69e-01
RND2 GTPase cycle 36 5.14e-01 6.25e-01 0.12600 0.111000 5.87e-02 2.49e-01 5.42e-01
Glutathione conjugation 26 5.61e-01 6.63e-01 0.12500 0.039100 1.19e-01 7.30e-01 2.93e-01
RND1 GTPase cycle 36 4.99e-01 6.10e-01 0.12500 0.053200 1.13e-01 5.80e-01 2.39e-01
Purine catabolism 16 6.81e-01 7.61e-01 0.12500 -0.121000 -3.09e-02 4.02e-01 8.31e-01
Synaptic adhesion-like molecules 14 5.89e-01 6.85e-01 0.12500 0.023500 -1.23e-01 8.79e-01 4.27e-01
Regulation of TP53 Activity through Phosphorylation 88 2.06e-02 6.38e-02 0.12500 -0.052600 1.13e-01 3.94e-01 6.64e-02
Metabolism of nucleotides 86 2.13e-02 6.55e-02 0.12400 -0.110000 5.83e-02 7.84e-02 3.50e-01
Role of second messengers in netrin-1 signaling 6 9.09e-01 9.35e-01 0.12400 0.100000 7.34e-02 6.72e-01 7.56e-01
Collagen biosynthesis and modifying enzymes 45 4.04e-01 5.27e-01 0.12400 0.115000 4.61e-02 1.82e-01 5.93e-01
Cardiogenesis 13 8.19e-01 8.71e-01 0.12400 -0.080200 -9.44e-02 6.17e-01 5.56e-01
PTK6 Regulates Cell Cycle 6 8.97e-01 9.27e-01 0.12400 0.110000 5.64e-02 6.41e-01 8.11e-01
Gene Silencing by RNA 87 2.43e-02 7.18e-02 0.12400 -0.113000 4.97e-02 6.83e-02 4.23e-01
Transcriptional regulation by small RNAs 61 1.91e-01 3.19e-01 0.12200 -0.122000 -1.32e-02 1.00e-01 8.59e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 3.39e-01 4.72e-01 0.12200 0.115000 -3.99e-02 2.99e-01 7.20e-01
The phototransduction cascade 26 3.54e-01 4.88e-01 0.12200 -0.116000 3.94e-02 3.08e-01 7.28e-01
MyD88-independent TLR4 cascade 108 2.05e-01 3.31e-01 0.12200 0.087500 8.51e-02 1.16e-01 1.27e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 2.05e-01 3.31e-01 0.12200 0.087500 8.51e-02 1.16e-01 1.27e-01
Autophagy 142 1.80e-03 9.47e-03 0.12200 -0.068300 1.01e-01 1.60e-01 3.79e-02
ECM proteoglycans 45 2.00e-01 3.28e-01 0.12200 0.120000 -2.25e-02 1.65e-01 7.94e-01
IGF1R signaling cascade 37 4.13e-01 5.36e-01 0.12200 0.119000 2.48e-02 2.10e-01 7.94e-01
Arachidonate metabolism 42 3.16e-01 4.50e-01 0.12100 0.121000 9.68e-03 1.76e-01 9.14e-01
WNT5A-dependent internalization of FZD4 13 7.06e-01 7.80e-01 0.12100 0.120000 1.21e-02 4.52e-01 9.40e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 6.97e-01 7.74e-01 0.12100 -0.113000 4.37e-02 5.59e-01 8.20e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.61e-01 4.93e-01 0.12100 0.030600 1.17e-01 7.19e-01 1.71e-01
Signaling by Non-Receptor Tyrosine Kinases 47 4.28e-01 5.48e-01 0.12100 0.110000 5.06e-02 1.94e-01 5.48e-01
Signaling by PTK6 47 4.28e-01 5.48e-01 0.12100 0.110000 5.06e-02 1.94e-01 5.48e-01
Signaling by FGFR in disease 52 2.66e-01 3.94e-01 0.12000 0.015500 1.19e-01 8.47e-01 1.37e-01
MAP kinase activation 63 4.01e-01 5.25e-01 0.12000 0.093300 7.49e-02 2.00e-01 3.04e-01
Glutamate Neurotransmitter Release Cycle 20 7.04e-01 7.79e-01 0.12000 0.108000 5.10e-02 4.03e-01 6.93e-01
Interleukin-17 signaling 68 3.55e-01 4.88e-01 0.11900 0.099400 6.62e-02 1.56e-01 3.45e-01
Transport and synthesis of PAPS 6 8.29e-01 8.80e-01 0.11900 -0.009490 1.19e-01 9.68e-01 6.15e-01
Adipogenesis 95 2.36e-01 3.66e-01 0.11900 0.099600 6.52e-02 9.35e-02 2.72e-01
PI-3K cascade:FGFR1 13 7.84e-01 8.47e-01 0.11900 0.111000 4.34e-02 4.90e-01 7.86e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 4.83e-01 5.96e-01 0.11900 0.067600 9.75e-02 4.13e-01 2.38e-01
Organelle biogenesis and maintenance 278 8.08e-06 9.02e-05 0.11900 -0.069100 9.64e-02 4.73e-02 5.67e-03
Transport of small molecules 548 4.04e-04 2.58e-03 0.11800 0.096400 6.81e-02 1.15e-04 6.38e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 7.75e-01 8.38e-01 0.11800 0.011400 1.17e-01 9.50e-01 5.21e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 5.77e-01 6.75e-01 0.11800 0.092800 -7.23e-02 5.62e-01 6.52e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 6.92e-01 7.70e-01 0.11800 -0.037000 1.12e-01 8.40e-01 5.41e-01
Neurotransmitter release cycle 38 4.33e-01 5.52e-01 0.11700 0.115000 2.51e-02 2.21e-01 7.89e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 3.13e-01 4.48e-01 0.11700 -0.017200 1.16e-01 8.58e-01 2.28e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 6.35e-01 7.25e-01 0.11700 -0.117000 1.67e-03 4.17e-01 9.91e-01
Biosynthesis of DHA-derived SPMs 13 5.92e-01 6.88e-01 0.11700 0.102000 -5.79e-02 5.25e-01 7.18e-01
mTORC1-mediated signalling 24 4.31e-01 5.51e-01 0.11700 -0.030100 1.13e-01 7.99e-01 3.37e-01
RNA Polymerase I Promoter Escape 45 2.42e-01 3.70e-01 0.11700 -0.116000 1.57e-02 1.80e-01 8.55e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 4.28e-01 5.48e-01 0.11600 0.098700 -6.18e-02 4.33e-01 6.24e-01
Neurodegenerative Diseases 21 4.28e-01 5.48e-01 0.11600 0.098700 -6.18e-02 4.33e-01 6.24e-01
Reversal of alkylation damage by DNA dioxygenases 7 9.10e-01 9.35e-01 0.11600 -0.085800 -7.85e-02 6.94e-01 7.19e-01
Phospholipase C-mediated cascade; FGFR3 5 8.44e-01 8.90e-01 0.11600 0.027100 -1.13e-01 9.17e-01 6.62e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 7.93e-01 8.54e-01 0.11600 -0.097000 -6.39e-02 5.02e-01 6.58e-01
Anchoring of the basal body to the plasma membrane 97 4.05e-02 1.06e-01 0.11600 -0.024700 1.13e-01 6.75e-01 5.42e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 7.28e-01 7.99e-01 0.11600 -0.099000 5.99e-02 6.28e-01 7.69e-01
FOXO-mediated transcription 57 2.43e-01 3.71e-01 0.11600 0.115000 1.00e-02 1.32e-01 8.96e-01
Triglyceride biosynthesis 9 7.03e-01 7.78e-01 0.11500 0.059800 -9.81e-02 7.56e-01 6.10e-01
Protein-protein interactions at synapses 54 1.71e-01 2.97e-01 0.11500 0.025000 -1.12e-01 7.51e-01 1.55e-01
Nuclear signaling by ERBB4 24 4.13e-01 5.36e-01 0.11400 0.104000 -4.69e-02 3.77e-01 6.91e-01
HSF1 activation 25 7.10e-01 7.83e-01 0.11400 0.065900 9.33e-02 5.68e-01 4.20e-01
FRS-mediated FGFR1 signaling 15 8.11e-01 8.66e-01 0.11400 0.095200 6.27e-02 5.23e-01 6.74e-01
HDACs deacetylate histones 45 5.46e-01 6.51e-01 0.11400 0.092000 6.68e-02 2.86e-01 4.38e-01
DNA Double-Strand Break Repair 137 4.85e-03 2.08e-02 0.11400 -0.066200 9.23e-02 1.81e-01 6.22e-02
IRS-mediated signalling 35 4.88e-01 6.00e-01 0.11400 0.111000 2.48e-02 2.57e-01 8.00e-01
VLDLR internalisation and degradation 16 6.99e-01 7.75e-01 0.11300 -0.016000 -1.12e-01 9.12e-01 4.37e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 7.37e-01 8.07e-01 0.11300 0.066900 9.12e-02 5.79e-01 4.49e-01
Resolution of D-Loop Structures 35 3.27e-01 4.60e-01 0.11300 -0.025400 1.10e-01 7.95e-01 2.59e-01
Metabolism of proteins 1761 2.28e-28 3.37e-26 0.11300 -0.079800 7.97e-02 2.81e-08 2.85e-08
Inactivation, recovery and regulation of the phototransduction cascade 25 3.80e-01 5.06e-01 0.11200 -0.081200 7.72e-02 4.82e-01 5.04e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 8.11e-01 8.66e-01 0.11200 -0.099800 -5.08e-02 5.18e-01 7.42e-01
Cellular hexose transport 14 6.12e-01 7.05e-01 0.11200 0.044400 -1.03e-01 7.74e-01 5.06e-01
Metabolism of lipids 632 2.28e-04 1.60e-03 0.11200 0.059600 9.46e-02 1.06e-02 4.92e-05
Post-translational protein modification 1232 2.24e-11 5.67e-10 0.11200 0.018700 1.10e-01 2.70e-01 8.18e-11
Intrinsic Pathway for Apoptosis 53 1.50e-01 2.72e-01 0.11100 -0.099100 5.09e-02 2.12e-01 5.22e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 6.72e-01 7.52e-01 0.11100 -0.054000 9.71e-02 7.56e-01 5.77e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 8.15e-01 8.69e-01 0.11100 0.057900 9.48e-02 6.98e-01 5.25e-01
Drug ADME 55 5.08e-01 6.19e-01 0.11100 0.085000 7.12e-02 2.76e-01 3.61e-01
SLC transporter disorders 75 3.99e-01 5.23e-01 0.11100 -0.071500 -8.44e-02 2.84e-01 2.06e-01
Post NMDA receptor activation events 60 4.73e-01 5.89e-01 0.11000 0.066900 8.77e-02 3.70e-01 2.40e-01
Passive transport by Aquaporins 6 8.91e-01 9.25e-01 0.11000 -0.023500 -1.07e-01 9.21e-01 6.49e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 8.73e-02 1.86e-01 0.11000 -0.079400 7.55e-02 2.65e-01 2.89e-01
Nuclear Envelope (NE) Reassembly 68 3.18e-01 4.51e-01 0.10900 0.033800 1.04e-01 6.30e-01 1.40e-01
Lewis blood group biosynthesis 13 8.49e-01 8.93e-01 0.10900 -0.090000 -6.07e-02 5.74e-01 7.05e-01
Inflammasomes 21 4.91e-01 6.03e-01 0.10800 0.096900 -4.88e-02 4.42e-01 6.99e-01
Signaling by NOTCH1 66 2.08e-01 3.35e-01 0.10800 0.108000 4.59e-04 1.28e-01 9.95e-01
Interferon gamma signaling 87 4.38e-02 1.13e-01 0.10800 -0.072100 8.07e-02 2.45e-01 1.93e-01
Formation of RNA Pol II elongation complex 56 1.39e-01 2.58e-01 0.10800 -0.061800 8.88e-02 4.24e-01 2.51e-01
RNA Polymerase II Transcription Elongation 56 1.39e-01 2.58e-01 0.10800 -0.061800 8.88e-02 4.24e-01 2.51e-01
Recruitment of NuMA to mitotic centrosomes 88 1.93e-01 3.20e-01 0.10800 0.022900 1.06e-01 7.10e-01 8.68e-02
Inositol phosphate metabolism 42 6.16e-01 7.08e-01 0.10800 0.077200 7.55e-02 3.87e-01 3.97e-01
TRP channels 21 6.41e-01 7.29e-01 0.10800 0.107000 1.08e-02 3.96e-01 9.31e-01
FasL/ CD95L signaling 5 8.47e-01 8.92e-01 0.10700 -0.096100 4.79e-02 7.10e-01 8.53e-01
Disease 1606 1.32e-14 4.69e-13 0.10700 0.008750 1.07e-01 5.59e-01 9.59e-13
Sphingolipid metabolism 92 3.51e-01 4.87e-01 0.10700 0.072100 7.92e-02 2.32e-01 1.89e-01
LDL clearance 18 5.31e-01 6.38e-01 0.10700 0.081900 -6.89e-02 5.47e-01 6.13e-01
MyD88 cascade initiated on plasma membrane 95 3.18e-01 4.50e-01 0.10600 0.088400 5.93e-02 1.36e-01 3.18e-01
Toll Like Receptor 10 (TLR10) Cascade 95 3.18e-01 4.50e-01 0.10600 0.088400 5.93e-02 1.36e-01 3.18e-01
Toll Like Receptor 5 (TLR5) Cascade 95 3.18e-01 4.50e-01 0.10600 0.088400 5.93e-02 1.36e-01 3.18e-01
ERKs are inactivated 13 7.49e-01 8.16e-01 0.10600 -0.003460 -1.06e-01 9.83e-01 5.07e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 7.46e-01 8.14e-01 0.10600 0.089100 5.80e-02 4.50e-01 6.23e-01
Death Receptor Signaling 145 1.84e-01 3.10e-01 0.10600 0.086200 6.17e-02 7.33e-02 2.00e-01
Signaling by Retinoic Acid 29 4.99e-01 6.10e-01 0.10600 -0.106000 5.31e-03 3.25e-01 9.61e-01
Senescence-Associated Secretory Phenotype (SASP) 64 4.83e-01 5.96e-01 0.10600 0.083300 6.51e-02 2.49e-01 3.68e-01
SLC15A4:TASL-dependent IRF5 activation 6 8.73e-01 9.10e-01 0.10500 -0.105000 3.77e-04 6.56e-01 9.99e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 78 4.27e-01 5.48e-01 0.10500 0.070200 7.78e-02 2.83e-01 2.35e-01
CASP8 activity is inhibited 11 6.90e-01 7.69e-01 0.10500 -0.079400 6.83e-02 6.49e-01 6.95e-01
Dimerization of procaspase-8 11 6.90e-01 7.69e-01 0.10500 -0.079400 6.83e-02 6.49e-01 6.95e-01
Regulation by c-FLIP 11 6.90e-01 7.69e-01 0.10500 -0.079400 6.83e-02 6.49e-01 6.95e-01
Negative feedback regulation of MAPK pathway 6 8.34e-01 8.83e-01 0.10400 0.096800 -3.93e-02 6.81e-01 8.68e-01
Signaling by BRAF and RAF1 fusions 59 4.92e-01 6.04e-01 0.10400 0.053800 8.91e-02 4.75e-01 2.36e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 2.56e-01 3.85e-01 0.10400 -0.001880 1.04e-01 9.80e-01 1.61e-01
Regulation of FZD by ubiquitination 15 8.52e-01 8.95e-01 0.10400 0.074000 7.27e-02 6.20e-01 6.26e-01
SIRT1 negatively regulates rRNA expression 22 5.91e-01 6.87e-01 0.10400 -0.009260 1.03e-01 9.40e-01 4.02e-01
Sensory processing of sound 57 3.91e-01 5.17e-01 0.10300 0.099800 2.37e-02 1.92e-01 7.57e-01
Intra-Golgi traffic 43 5.69e-01 6.67e-01 0.10200 0.041900 9.33e-02 6.34e-01 2.90e-01
Regulation of MITF-M-dependent genes involved in pigmentation 35 3.88e-01 5.15e-01 0.10200 0.097800 -2.86e-02 3.17e-01 7.70e-01
Signaling by FGFR1 42 6.45e-01 7.33e-01 0.10200 0.065400 7.81e-02 4.63e-01 3.81e-01
Regulation of TP53 Degradation 35 3.26e-01 4.59e-01 0.10200 -0.072400 7.16e-02 4.59e-01 4.63e-01
DNA Double Strand Break Response 47 4.74e-01 5.89e-01 0.10200 0.025300 9.86e-02 7.64e-01 2.42e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 5.35e-01 6.42e-01 0.10100 0.000341 1.01e-01 9.97e-01 3.37e-01
Disorders of transmembrane transporters 134 9.86e-02 2.01e-01 0.10100 0.016200 9.96e-02 7.46e-01 4.65e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 6.71e-02 1.53e-01 0.10100 -0.026700 9.71e-02 6.39e-01 8.72e-02
p75 NTR receptor-mediated signalling 89 3.11e-01 4.45e-01 0.10000 0.093000 3.74e-02 1.29e-01 5.41e-01
G-protein beta:gamma signalling 29 6.75e-01 7.55e-01 0.10000 0.034800 9.38e-02 7.46e-01 3.82e-01
Carboxyterminal post-translational modifications of tubulin 33 4.11e-01 5.35e-01 0.09940 0.093100 -3.49e-02 3.55e-01 7.29e-01
SARS-CoV-2 Infection 263 5.65e-04 3.39e-03 0.09940 -0.087500 4.70e-02 1.46e-02 1.89e-01
Metal ion SLC transporters 19 7.83e-01 8.46e-01 0.09900 0.091800 3.70e-02 4.88e-01 7.80e-01
Amyloid fiber formation 51 3.72e-01 5.02e-01 0.09890 0.002630 9.89e-02 9.74e-01 2.22e-01
Amine ligand-binding receptors 10 8.19e-01 8.71e-01 0.09850 0.098500 -7.06e-04 5.90e-01 9.97e-01
Oncogenic MAPK signaling 75 4.70e-01 5.86e-01 0.09820 0.057000 8.00e-02 3.94e-01 2.31e-01
Negative epigenetic regulation of rRNA expression 63 1.92e-01 3.19e-01 0.09740 -0.090300 3.65e-02 2.15e-01 6.16e-01
TGFBR3 PTM regulation 10 8.90e-01 9.25e-01 0.09680 0.040700 8.78e-02 8.24e-01 6.31e-01
Fertilization 12 7.12e-01 7.84e-01 0.09650 0.077600 -5.74e-02 6.42e-01 7.31e-01
Phospholipase C-mediated cascade; FGFR4 6 8.62e-01 9.03e-01 0.09640 0.029700 -9.17e-02 9.00e-01 6.97e-01
Regulation of endogenous retroelements 92 2.86e-01 4.17e-01 0.09600 0.026600 9.22e-02 6.59e-01 1.26e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 4.09e-01 5.33e-01 0.09590 0.095600 -7.85e-03 2.73e-01 9.28e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 6.96e-01 7.74e-01 0.09570 -0.077300 5.64e-02 6.30e-01 7.25e-01
Carnitine shuttle 12 8.94e-01 9.26e-01 0.09570 -0.074900 -5.95e-02 6.53e-01 7.21e-01
Sensory processing of sound by inner hair cells of the cochlea 54 3.94e-01 5.19e-01 0.09570 0.095400 6.99e-03 2.25e-01 9.29e-01
TNFR1-induced proapoptotic signaling 24 6.95e-01 7.73e-01 0.09570 0.094000 1.78e-02 4.25e-01 8.80e-01
Josephin domain DUBs 10 8.36e-01 8.83e-01 0.09540 0.003130 9.54e-02 9.86e-01 6.02e-01
Centrosome maturation 81 1.76e-01 3.02e-01 0.09500 -0.015700 9.37e-02 8.07e-01 1.45e-01
Recruitment of mitotic centrosome proteins and complexes 81 1.76e-01 3.02e-01 0.09500 -0.015700 9.37e-02 8.07e-01 1.45e-01
Plasma lipoprotein clearance 33 4.38e-01 5.56e-01 0.09450 0.037500 -8.68e-02 7.10e-01 3.88e-01
Developmental Biology 906 4.24e-04 2.68e-03 0.09410 0.059600 7.28e-02 2.35e-03 2.04e-04
Homology Directed Repair 110 5.80e-02 1.37e-01 0.09380 -0.047400 8.09e-02 3.90e-01 1.43e-01
PI3K Cascade 31 5.20e-01 6.29e-01 0.09340 0.091700 -1.73e-02 3.77e-01 8.67e-01
TRAF6 mediated NF-kB activation 23 7.66e-01 8.31e-01 0.09290 -0.033100 -8.69e-02 7.83e-01 4.71e-01
Vitamin B2 (riboflavin) metabolism 6 9.48e-01 9.62e-01 0.09290 -0.056600 -7.37e-02 8.10e-01 7.55e-01
Retrograde neurotrophin signalling 12 8.56e-01 8.98e-01 0.09280 0.089600 2.44e-02 5.91e-01 8.84e-01
EPH-ephrin mediated repulsion of cells 42 5.83e-01 6.80e-01 0.09190 0.023400 8.89e-02 7.93e-01 3.19e-01
Cytosolic sensors of pathogen-associated DNA 63 4.46e-01 5.64e-01 0.09170 -0.088800 -2.30e-02 2.23e-01 7.52e-01
RHOBTB3 ATPase cycle 10 8.14e-01 8.68e-01 0.09150 0.089500 -1.88e-02 6.24e-01 9.18e-01
Nucleotide catabolism 29 5.30e-01 6.38e-01 0.09050 -0.028800 8.58e-02 7.89e-01 4.24e-01
TRAF3-dependent IRF activation pathway 13 8.71e-01 9.09e-01 0.08980 0.033300 8.34e-02 8.35e-01 6.02e-01
Pyrimidine salvage 10 9.15e-01 9.38e-01 0.08940 0.076900 4.56e-02 6.74e-01 8.03e-01
SARS-CoV-1 activates/modulates innate immune responses 40 3.81e-01 5.07e-01 0.08890 -0.054500 7.02e-02 5.51e-01 4.42e-01
Cytosolic sulfonation of small molecules 18 7.38e-01 8.08e-01 0.08860 0.004430 -8.85e-02 9.74e-01 5.15e-01
RNA Polymerase II Transcription 1185 1.92e-09 3.89e-08 0.08820 -0.011100 8.75e-02 5.22e-01 3.91e-07
Regulation of signaling by NODAL 6 9.12e-01 9.36e-01 0.08810 -0.088100 -2.54e-03 7.09e-01 9.91e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 4.25e-01 5.47e-01 0.08810 -0.085100 -2.28e-02 2.09e-01 7.36e-01
NoRC negatively regulates rRNA expression 60 2.46e-01 3.73e-01 0.08790 -0.071600 5.10e-02 3.37e-01 4.95e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 7.54e-01 8.20e-01 0.08770 0.084000 -2.54e-02 5.86e-01 8.70e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 7.54e-01 8.20e-01 0.08770 0.084000 -2.54e-02 5.86e-01 8.70e-01
TNF signaling 56 6.07e-01 7.02e-01 0.08690 0.039800 7.72e-02 6.06e-01 3.18e-01
Signaling by Hippo 18 8.48e-01 8.92e-01 0.08670 0.037400 7.82e-02 7.84e-01 5.66e-01
VEGFR2 mediated vascular permeability 26 6.54e-01 7.36e-01 0.08620 0.085900 -6.69e-03 4.48e-01 9.53e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 8.38e-01 8.85e-01 0.08610 -0.069200 -5.12e-02 5.65e-01 6.71e-01
Negative regulation of MAPK pathway 42 7.33e-01 8.04e-01 0.08600 0.064800 5.66e-02 4.67e-01 5.26e-01
Aspartate and asparagine metabolism 8 9.41e-01 9.58e-01 0.08600 -0.068100 -5.25e-02 7.39e-01 7.97e-01
RNA polymerase II transcribes snRNA genes 71 2.04e-01 3.31e-01 0.08570 -0.067600 5.28e-02 3.25e-01 4.42e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 107 1.61e-01 2.85e-01 0.08560 -0.084800 1.22e-02 1.30e-01 8.27e-01
Signaling by FGFR2 in disease 33 4.75e-01 5.89e-01 0.08560 -0.064200 5.66e-02 5.23e-01 5.73e-01
Visual phototransduction 58 3.90e-01 5.17e-01 0.08530 0.085000 -7.90e-03 2.63e-01 9.17e-01
Association of TriC/CCT with target proteins during biosynthesis 35 4.81e-01 5.94e-01 0.08530 -0.038100 7.63e-02 6.96e-01 4.35e-01
Generic Transcription Pathway 1067 1.33e-07 2.10e-06 0.08490 -0.005030 8.48e-02 7.82e-01 2.94e-06
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 7.33e-01 8.04e-01 0.08430 -0.074200 3.99e-02 6.19e-01 7.89e-01
Costimulation by the CD28 family 74 2.63e-01 3.92e-01 0.08400 -0.081200 2.16e-02 2.27e-01 7.48e-01
Urea cycle 6 8.97e-01 9.27e-01 0.08400 0.081200 -2.14e-02 7.31e-01 9.28e-01
Glycogen storage diseases 13 8.31e-01 8.81e-01 0.08400 -0.084000 -7.75e-04 6.00e-01 9.96e-01
Formation of definitive endoderm 8 9.28e-01 9.49e-01 0.08390 0.078100 3.07e-02 7.02e-01 8.81e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 7.46e-01 8.14e-01 0.08380 0.081300 2.05e-02 4.65e-01 8.54e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 10 8.05e-01 8.63e-01 0.08380 0.056400 -6.20e-02 7.57e-01 7.34e-01
Diseases associated with glycosylation precursor biosynthesis 15 8.71e-01 9.09e-01 0.08360 -0.077700 -3.11e-02 6.03e-01 8.35e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 4.72e-01 5.87e-01 0.08340 0.066800 5.00e-02 2.37e-01 3.77e-01
SUMOylation of DNA methylation proteins 16 8.35e-01 8.83e-01 0.08340 -0.016900 -8.17e-02 9.07e-01 5.72e-01
FGFRL1 modulation of FGFR1 signaling 7 9.51e-01 9.64e-01 0.08330 0.049300 6.72e-02 8.21e-01 7.58e-01
Activation of NMDA receptors and postsynaptic events 70 6.09e-01 7.03e-01 0.08320 0.066100 5.06e-02 3.39e-01 4.64e-01
Mitochondrial biogenesis 91 1.45e-01 2.65e-01 0.08310 -0.061800 5.57e-02 3.09e-01 3.59e-01
Phospholipid metabolism 182 2.89e-01 4.20e-01 0.08280 0.053500 6.31e-02 2.13e-01 1.42e-01
Phase I - Functionalization of compounds 62 4.16e-01 5.38e-01 0.08190 0.002920 -8.19e-02 9.68e-01 2.65e-01
Gene expression (Transcription) 1391 1.03e-10 2.42e-09 0.08180 -0.024400 7.81e-02 1.27e-01 1.07e-06
MyD88 dependent cascade initiated on endosome 101 4.83e-01 5.96e-01 0.08100 0.069100 4.23e-02 2.30e-01 4.62e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 8.07e-01 8.64e-01 0.08080 -0.080400 -8.38e-03 5.55e-01 9.51e-01
Beta-oxidation of very long chain fatty acids 11 9.31e-01 9.51e-01 0.08050 0.059800 5.39e-02 7.31e-01 7.57e-01
Amino acid transport across the plasma membrane 24 6.40e-01 7.29e-01 0.08000 -0.037800 7.05e-02 7.49e-01 5.50e-01
Transcriptional Regulation by VENTX 38 6.15e-01 7.07e-01 0.07920 -0.079200 2.23e-05 3.98e-01 1.00e+00
Metabolism of porphyrins 22 6.63e-01 7.45e-01 0.07880 0.044100 -6.53e-02 7.20e-01 5.96e-01
Signaling by NOTCH2 33 5.43e-01 6.48e-01 0.07790 0.047000 -6.21e-02 6.40e-01 5.37e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 9.07e-01 9.35e-01 0.07780 0.001120 7.78e-02 9.96e-01 7.03e-01
Toll Like Receptor 9 (TLR9) Cascade 108 5.24e-01 6.33e-01 0.07780 0.056500 5.35e-02 3.10e-01 3.37e-01
Nicotinamide salvaging 15 9.14e-01 9.37e-01 0.07780 0.051700 5.81e-02 7.29e-01 6.97e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 8.34e-01 8.83e-01 0.07720 0.077200 5.71e-04 6.05e-01 9.97e-01
Listeria monocytogenes entry into host cells 17 8.09e-01 8.65e-01 0.07590 -0.004490 7.58e-02 9.74e-01 5.89e-01
Positive epigenetic regulation of rRNA expression 60 6.81e-01 7.61e-01 0.07520 -0.065200 -3.74e-02 3.82e-01 6.16e-01
Paracetamol ADME 19 7.20e-01 7.92e-01 0.07490 0.055100 -5.07e-02 6.78e-01 7.02e-01
Caspase activation via Death Receptors in the presence of ligand 16 8.10e-01 8.66e-01 0.07450 -0.073500 1.22e-02 6.11e-01 9.33e-01
Metabolism of water-soluble vitamins and cofactors 114 1.63e-01 2.87e-01 0.07360 -0.037000 6.36e-02 4.96e-01 2.40e-01
Nef Mediated CD4 Down-regulation 9 8.63e-01 9.03e-01 0.07330 0.044300 -5.84e-02 8.18e-01 7.62e-01
Sensory processing of sound by outer hair cells of the cochlea 40 5.42e-01 6.48e-01 0.07290 0.065000 -3.29e-02 4.77e-01 7.19e-01
FOXO-mediated transcription of cell cycle genes 14 8.92e-01 9.26e-01 0.07260 0.070500 1.75e-02 6.48e-01 9.10e-01
NGF-stimulated transcription 32 6.00e-01 6.95e-01 0.07250 0.058500 -4.28e-02 5.67e-01 6.75e-01
Prevention of phagosomal-lysosomal fusion 9 8.70e-01 9.09e-01 0.07250 -0.035800 6.30e-02 8.52e-01 7.43e-01
SLC-mediated transmembrane transport 171 3.18e-01 4.50e-01 0.07230 0.066700 2.79e-02 1.32e-01 5.29e-01
Transcriptional activation of mitochondrial biogenesis 52 7.41e-01 8.10e-01 0.07200 0.037000 6.18e-02 6.44e-01 4.41e-01
Metabolism 1808 2.11e-11 5.40e-10 0.07190 -0.064500 3.17e-02 5.48e-06 2.54e-02
Fatty acid metabolism 152 1.07e-01 2.15e-01 0.07160 -0.032200 6.40e-02 4.93e-01 1.74e-01
Defensins 8 9.17e-01 9.39e-01 0.07150 0.002590 -7.15e-02 9.90e-01 7.26e-01
MECP2 regulates transcription factors 5 9.42e-01 9.58e-01 0.07140 -0.010800 7.06e-02 9.67e-01 7.85e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 8.73e-01 9.10e-01 0.07130 0.070000 -1.37e-02 6.88e-01 9.38e-01
TICAM1-dependent activation of IRF3/IRF7 13 8.16e-01 8.70e-01 0.07120 -0.046900 5.36e-02 7.70e-01 7.38e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 6.68e-01 7.49e-01 0.07110 -0.036000 6.13e-02 7.46e-01 5.81e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 5.53e-01 6.55e-01 0.07110 0.063000 3.29e-02 2.76e-01 5.69e-01
Cellular responses to stimuli 776 8.89e-04 5.11e-03 0.07030 0.004770 7.02e-02 8.21e-01 8.87e-04
Regulation of HSF1-mediated heat shock response 78 3.75e-01 5.04e-01 0.06970 -0.067000 1.93e-02 3.06e-01 7.69e-01
Regulation of PTEN gene transcription 59 6.67e-01 7.48e-01 0.06960 -0.021600 -6.61e-02 7.74e-01 3.80e-01
Nuclear Envelope Breakdown 53 5.22e-01 6.31e-01 0.06940 -0.067100 1.75e-02 3.98e-01 8.25e-01
Cell-cell junction organization 56 4.74e-01 5.89e-01 0.06860 0.062400 -2.86e-02 4.19e-01 7.11e-01
Axon guidance 455 4.59e-02 1.16e-01 0.06850 0.019300 6.58e-02 4.80e-01 1.62e-02
RMTs methylate histone arginines 35 8.38e-01 8.85e-01 0.06840 -0.057400 -3.71e-02 5.57e-01 7.04e-01
Sensory perception of taste 23 8.09e-01 8.65e-01 0.06830 -0.002010 -6.83e-02 9.87e-01 5.71e-01
Regulation of TNFR1 signaling 47 8.04e-01 8.63e-01 0.06830 0.050500 4.61e-02 5.50e-01 5.85e-01
Regulation of TP53 Expression and Degradation 36 5.96e-01 6.91e-01 0.06830 -0.045600 5.08e-02 6.36e-01 5.98e-01
Nervous system development 473 3.32e-02 9.26e-02 0.06810 0.015000 6.64e-02 5.77e-01 1.34e-02
MTOR signalling 39 6.28e-01 7.19e-01 0.06790 -0.065300 1.85e-02 4.80e-01 8.42e-01
Sperm Motility And Taxes 6 9.67e-01 9.74e-01 0.06780 -0.028700 -6.14e-02 9.03e-01 7.95e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 8.90e-01 9.25e-01 0.06660 -0.061900 -2.46e-02 6.32e-01 8.49e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 20 8.05e-01 8.63e-01 0.06530 0.016100 -6.33e-02 9.01e-01 6.24e-01
Signaling by FGFR2 61 4.51e-01 5.66e-01 0.06520 -0.047800 4.43e-02 5.19e-01 5.50e-01
Activation of HOX genes during differentiation 68 4.75e-01 5.89e-01 0.06400 -0.020400 6.07e-02 7.71e-01 3.87e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 4.75e-01 5.89e-01 0.06400 -0.020400 6.07e-02 7.71e-01 3.87e-01
Cell death signalling via NRAGE, NRIF and NADE 69 7.45e-01 8.13e-01 0.06370 0.052300 3.63e-02 4.52e-01 6.02e-01
Transcriptional Regulation by TP53 343 2.16e-02 6.62e-02 0.06350 -0.025600 5.81e-02 4.15e-01 6.44e-02
Xenobiotics 9 8.98e-01 9.27e-01 0.06340 0.053900 -3.35e-02 7.79e-01 8.62e-01
Negative regulation of FGFR1 signaling 25 9.04e-01 9.32e-01 0.06260 0.037200 5.03e-02 7.47e-01 6.63e-01
Regulation of TP53 Activity 151 2.08e-01 3.35e-01 0.06230 -0.058800 2.07e-02 2.13e-01 6.60e-01
Lysosome Vesicle Biogenesis 32 7.18e-01 7.91e-01 0.06220 -0.019900 5.89e-02 8.45e-01 5.64e-01
Vitamin D (calciferol) metabolism 10 9.63e-01 9.71e-01 0.06130 0.038400 4.77e-02 8.33e-01 7.94e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 8.67e-01 9.07e-01 0.06110 0.011000 6.01e-02 9.27e-01 6.18e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 6.88e-01 7.67e-01 0.06070 0.060400 6.47e-03 4.34e-01 9.33e-01
Basigin interactions 21 9.27e-01 9.48e-01 0.06010 0.045100 3.98e-02 7.21e-01 7.52e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 8.91e-01 9.25e-01 0.06010 0.035900 4.82e-02 7.29e-01 6.42e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 8.81e-01 9.17e-01 0.05990 0.010200 5.91e-02 9.35e-01 6.39e-01
Aflatoxin activation and detoxification 14 9.51e-01 9.64e-01 0.05970 0.038800 4.54e-02 8.02e-01 7.69e-01
Cellular responses to stress 694 1.09e-03 6.03e-03 0.05960 -0.026000 5.36e-02 2.44e-01 1.61e-02
Nuclear Events (kinase and transcription factor activation) 54 7.09e-01 7.83e-01 0.05930 0.058900 6.40e-03 4.54e-01 9.35e-01
PKMTs methylate histone lysines 42 8.56e-01 8.98e-01 0.05830 0.049300 3.11e-02 5.80e-01 7.27e-01
IRAK1 recruits IKK complex 14 8.94e-01 9.26e-01 0.05820 -0.057500 9.09e-03 7.10e-01 9.53e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 8.94e-01 9.26e-01 0.05820 -0.057500 9.09e-03 7.10e-01 9.53e-01
Activated point mutants of FGFR2 7 9.45e-01 9.60e-01 0.05820 -0.010300 5.72e-02 9.62e-01 7.93e-01
Epigenetic regulation of gene expression 263 2.18e-01 3.46e-01 0.05810 0.008470 5.74e-02 8.13e-01 1.09e-01
Cellular response to heat stress 92 6.74e-01 7.55e-01 0.05710 -0.053100 -2.10e-02 3.79e-01 7.28e-01
TNFs bind their physiological receptors 25 9.04e-01 9.32e-01 0.05670 0.023200 5.17e-02 8.41e-01 6.55e-01
Phase II - Conjugation of compounds 68 6.25e-01 7.15e-01 0.05660 -0.003270 5.65e-02 9.63e-01 4.20e-01
Endogenous sterols 17 8.55e-01 8.98e-01 0.05620 0.026600 -4.94e-02 8.49e-01 7.24e-01
Cargo recognition for clathrin-mediated endocytosis 88 6.12e-01 7.05e-01 0.05540 0.005790 5.51e-02 9.25e-01 3.71e-01
Metabolism of folate and pterines 16 9.46e-01 9.61e-01 0.05530 -0.027800 -4.78e-02 8.47e-01 7.41e-01
Diseases of glycosylation 104 4.20e-01 5.43e-01 0.05480 0.021300 -5.05e-02 7.08e-01 3.74e-01
NCAM signaling for neurite out-growth 47 8.19e-01 8.71e-01 0.05460 0.052000 1.68e-02 5.38e-01 8.42e-01
Metabolic disorders of biological oxidation enzymes 23 8.21e-01 8.72e-01 0.05390 0.046900 -2.66e-02 6.97e-01 8.25e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 9.09e-01 9.35e-01 0.05340 -0.043100 3.15e-02 8.04e-01 8.57e-01
Synthesis of PA 31 8.01e-01 8.61e-01 0.05330 -0.012400 5.18e-02 9.05e-01 6.17e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 9.63e-01 9.71e-01 0.05330 0.053200 3.44e-03 8.08e-01 9.87e-01
Reactions specific to the complex N-glycan synthesis pathway 7 9.61e-01 9.70e-01 0.05270 -0.000444 5.27e-02 9.98e-01 8.09e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 6.51e-01 7.35e-01 0.05150 0.040700 -3.16e-02 6.08e-01 6.90e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 6.51e-01 7.35e-01 0.05150 0.040700 -3.16e-02 6.08e-01 6.90e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 6.51e-01 7.35e-01 0.05150 0.040700 -3.16e-02 6.08e-01 6.90e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 6.51e-01 7.35e-01 0.05150 0.040700 -3.16e-02 6.08e-01 6.90e-01
Signaling by NOTCH1 in Cancer 53 6.51e-01 7.35e-01 0.05150 0.040700 -3.16e-02 6.08e-01 6.90e-01
TRIF-mediated programmed cell death 9 9.39e-01 9.57e-01 0.05000 -0.020100 4.58e-02 9.17e-01 8.12e-01
SUMOylation of transcription cofactors 44 8.49e-01 8.93e-01 0.04770 -0.009340 -4.68e-02 9.15e-01 5.92e-01
Glucose metabolism 76 8.46e-01 8.92e-01 0.04720 0.034200 3.26e-02 6.06e-01 6.23e-01
WNT ligand biogenesis and trafficking 20 8.96e-01 9.27e-01 0.04710 -0.010200 4.59e-02 9.37e-01 7.22e-01
Glyoxylate metabolism and glycine degradation 13 9.16e-01 9.38e-01 0.04700 -0.037100 2.89e-02 8.17e-01 8.57e-01
HCMV Infection 106 4.87e-01 5.99e-01 0.04700 -0.032500 3.40e-02 5.64e-01 5.45e-01
Transport of RCbl within the body 8 9.60e-01 9.70e-01 0.04620 -0.008010 4.55e-02 9.69e-01 8.24e-01
HCMV Early Events 84 7.67e-01 8.32e-01 0.04570 -0.044100 -1.18e-02 4.84e-01 8.52e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 9.30e-01 9.51e-01 0.04510 -0.035000 -2.85e-02 7.20e-01 7.70e-01
Glycolysis 68 8.59e-01 9.00e-01 0.04470 0.022600 3.86e-02 7.47e-01 5.82e-01
Biological oxidations 135 7.63e-01 8.28e-01 0.04430 -0.026900 -3.53e-02 5.89e-01 4.79e-01
Acyl chain remodelling of PE 19 9.64e-01 9.72e-01 0.04400 -0.029300 -3.29e-02 8.25e-01 8.04e-01
Diseases associated with glycosaminoglycan metabolism 24 8.93e-01 9.26e-01 0.04400 0.043200 -8.61e-03 7.14e-01 9.42e-01
FGFR4 ligand binding and activation 5 9.79e-01 9.84e-01 0.04400 0.003330 -4.39e-02 9.90e-01 8.65e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 9.31e-01 9.51e-01 0.04390 -0.031200 3.09e-02 8.52e-01 8.53e-01
Signaling by ERBB2 44 8.78e-01 9.14e-01 0.04330 0.009550 4.22e-02 9.13e-01 6.28e-01
RUNX2 regulates osteoblast differentiation 16 9.55e-01 9.67e-01 0.04320 0.041900 1.07e-02 7.72e-01 9.41e-01
Signaling by NODAL 15 9.61e-01 9.70e-01 0.04270 -0.012400 -4.09e-02 9.33e-01 7.84e-01
NOD1/2 Signaling Pathway 36 9.08e-01 9.35e-01 0.04250 0.011800 4.08e-02 9.03e-01 6.72e-01
GABA synthesis, release, reuptake and degradation 12 9.39e-01 9.57e-01 0.04200 -0.021800 3.59e-02 8.96e-01 8.30e-01
Metabolism of vitamins and cofactors 163 4.64e-01 5.80e-01 0.04090 -0.017200 3.71e-02 7.05e-01 4.14e-01
Effects of PIP2 hydrolysis 24 9.61e-01 9.70e-01 0.04080 -0.026900 -3.07e-02 8.20e-01 7.95e-01
FLT3 signaling through SRC family kinases 6 9.83e-01 9.88e-01 0.03930 0.003640 3.91e-02 9.88e-01 8.68e-01
Chromatin modifying enzymes 213 5.63e-01 6.63e-01 0.03930 0.039000 5.26e-03 3.27e-01 8.95e-01
Chromatin organization 213 5.63e-01 6.63e-01 0.03930 0.039000 5.26e-03 3.27e-01 8.95e-01
Iron uptake and transport 52 9.13e-01 9.37e-01 0.03920 0.019300 3.41e-02 8.09e-01 6.71e-01
Diseases of metabolism 198 7.24e-01 7.96e-01 0.03900 -0.032700 -2.11e-02 4.27e-01 6.09e-01
HCMV Late Events 67 7.83e-01 8.46e-01 0.03870 -0.037900 7.83e-03 5.92e-01 9.12e-01
Glutamate and glutamine metabolism 12 9.47e-01 9.61e-01 0.03830 -0.029700 2.42e-02 8.59e-01 8.84e-01
Signaling by FGFR 73 7.29e-01 8.01e-01 0.03780 -0.030800 2.20e-02 6.49e-01 7.46e-01
SUMOylation 167 5.08e-01 6.19e-01 0.03660 -0.021700 2.95e-02 6.28e-01 5.11e-01
Lysosphingolipid and LPA receptors 11 9.85e-01 9.89e-01 0.03650 0.029500 2.16e-02 8.66e-01 9.01e-01
Amino acids regulate mTORC1 48 8.32e-01 8.82e-01 0.03530 0.025500 -2.43e-02 7.60e-01 7.71e-01
Metabolism of carbohydrates 236 6.01e-01 6.96e-01 0.03520 0.034900 4.78e-03 3.56e-01 8.99e-01
Diseases of programmed cell death 58 8.07e-01 8.64e-01 0.03480 -0.027300 2.17e-02 7.20e-01 7.75e-01
TNFR1-induced NF-kappa-B signaling pathway 32 8.98e-01 9.27e-01 0.03460 -0.014200 3.15e-02 8.89e-01 7.58e-01
Synthesis of substrates in N-glycan biosythesis 58 9.08e-01 9.35e-01 0.03360 -0.032300 -9.38e-03 6.71e-01 9.02e-01
Glycosphingolipid metabolism 47 9.40e-01 9.57e-01 0.03350 0.029700 1.55e-02 7.25e-01 8.54e-01
CD28 co-stimulation 33 9.02e-01 9.31e-01 0.03240 -0.017300 2.74e-02 8.64e-01 7.85e-01
Unfolded Protein Response (UPR) 84 9.15e-01 9.38e-01 0.03200 0.018900 2.58e-02 7.65e-01 6.83e-01
Metabolism of steroid hormones 21 9.40e-01 9.57e-01 0.03190 0.014900 -2.82e-02 9.06e-01 8.23e-01
HATs acetylate histones 92 9.10e-01 9.35e-01 0.03080 -0.026000 -1.64e-02 6.66e-01 7.86e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 36 9.33e-01 9.52e-01 0.02870 -0.028400 4.16e-03 7.68e-01 9.66e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 9.72e-01 9.78e-01 0.02800 0.004370 2.77e-02 9.72e-01 8.26e-01
SHC-mediated cascade:FGFR1 13 9.90e-01 9.93e-01 0.02740 0.022800 1.52e-02 8.87e-01 9.24e-01
B-WICH complex positively regulates rRNA expression 45 9.68e-01 9.74e-01 0.02670 -0.016500 -2.10e-02 8.49e-01 8.07e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 9.59e-01 9.70e-01 0.02580 0.023900 -9.65e-03 8.42e-01 9.36e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 9.59e-01 9.70e-01 0.02580 0.023900 -9.65e-03 8.42e-01 9.36e-01
Glycerophospholipid biosynthesis 104 8.91e-01 9.25e-01 0.02420 0.001530 2.42e-02 9.78e-01 6.70e-01
TAK1-dependent IKK and NF-kappa-B activation 43 9.47e-01 9.61e-01 0.02400 0.024000 -1.77e-03 7.86e-01 9.84e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 9.70e-01 9.76e-01 0.02370 0.005010 -2.31e-02 9.68e-01 8.51e-01
SUMO E3 ligases SUMOylate target proteins 161 8.50e-01 8.93e-01 0.01930 -0.006760 1.81e-02 8.82e-01 6.92e-01
Histidine catabolism 7 9.98e-01 9.99e-01 0.01890 0.014300 1.24e-02 9.48e-01 9.55e-01
Phospholipase C-mediated cascade; FGFR2 8 9.98e-01 9.99e-01 0.01420 0.011200 8.70e-03 9.56e-01 9.66e-01
Synthesis of PC 23 9.92e-01 9.95e-01 0.01090 -0.007310 8.12e-03 9.52e-01 9.46e-01
ERK/MAPK targets 22 9.96e-01 9.98e-01 0.00971 -0.000257 9.71e-03 9.98e-01 9.37e-01
Activation of BAD and translocation to mitochondria 15 9.99e-01 9.99e-01 0.00622 -0.003570 -5.09e-03 9.81e-01 9.73e-01
CD209 (DC-SIGN) signaling 20 9.99e-01 9.99e-01 0.00616 0.001560 5.96e-03 9.90e-01 9.63e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 9.99e-01 9.99e-01 0.00590 0.002540 -5.33e-03 9.91e-01 9.81e-01


Detailed Gene set reports


Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
metric value
setSize 6
pMANOVA 0.00164
p.adjustMANOVA 0.00875
s.dist 1.02
s.crp_pod1_adj 0.814
s.avb_pod1_adj 0.61
p.crp_pod1_adj 0.000554
p.avb_pod1_adj 0.00964



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
H19 9980 11006
IGF2BP3 9845 10913
CD44 8699 10682
ACTB 7610 7384
MYC 8860 4670

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All member genes
crp_pod1_adj avb_pod1_adj
ACTB 7610 7384
CD44 8699 10682
H19 9980 11006
IGF2BP2 5158 -3329
IGF2BP3 9845 10913
MYC 8860 4670



Response to metal ions
Response to metal ions
metric value
setSize 6
pMANOVA 0.00202
p.adjustMANOVA 0.0103
s.dist 1.01
s.crp_pod1_adj 0.774
s.avb_pod1_adj 0.656
p.crp_pod1_adj 0.00103
p.avb_pod1_adj 0.00536



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
MTF1 9776 8964
MT1X 9137 9545
MT2A 8856 5339
MT1E 8758 4932
CSRP1 5132 8367
MT1F 5937 7120

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All member genes
crp_pod1_adj avb_pod1_adj
CSRP1 5132 8367
MT1E 8758 4932
MT1F 5937 7120
MT1X 9137 9545
MT2A 8856 5339
MTF1 9776 8964



G2/M DNA replication checkpoint
G2/M DNA replication checkpoint
metric value
setSize 5
pMANOVA 0.00983
p.adjustMANOVA 0.0372
s.dist 0.966
s.crp_pod1_adj 0.692
s.avb_pod1_adj 0.674
p.crp_pod1_adj 0.0074
p.avb_pod1_adj 0.009



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
CDK1 8897 10881
CCNB1 7371 10139
CCNB2 5317 9037
PKMYT1 6506 4319
WEE1 7202 3478

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All member genes
crp_pod1_adj avb_pod1_adj
CCNB1 7371 10139
CCNB2 5317 9037
CDK1 8897 10881
PKMYT1 6506 4319
WEE1 7202 3478



Fructose metabolism
Fructose metabolism
metric value
setSize 7
pMANOVA 0.00281
p.adjustMANOVA 0.0135
s.dist 0.912
s.crp_pod1_adj -0.581
s.avb_pod1_adj -0.703
p.crp_pod1_adj 0.00778
p.avb_pod1_adj 0.00127



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
ALDH1A1 -10915 -10189
TKFC -10688 -10039
AKR1B1 -10849 -9591
KHK -10573 -9273
SORD -7095 -6385

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All member genes
crp_pod1_adj avb_pod1_adj
AKR1B1 -10849 -9591
ALDH1A1 -10915 -10189
ALDOB 2371 67
GLYCTK 2531 -4043
KHK -10573 -9273
SORD -7095 -6385
TKFC -10688 -10039



CD163 mediating an anti-inflammatory response
CD163 mediating an anti-inflammatory response
metric value
setSize 8
pMANOVA 1.62e-06
p.adjustMANOVA 2.08e-05
s.dist 0.875
s.crp_pod1_adj 0.873
s.avb_pod1_adj -0.0579
p.crp_pod1_adj 1.91e-05
p.avb_pod1_adj 0.777



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
CD163 8710 -8966
PLK2 7307 -8555
RHBDF2 8363 -3425

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All member genes
crp_pod1_adj avb_pod1_adj
ADAM17 9123 921
CD163 8710 -8966
FURIN 9787 271
IL10 9783 1001
MAPK14 10146 10644
MYH9 8624 6428
PLK2 7307 -8555
RHBDF2 8363 -3425



Butyrophilin (BTN) family interactions
Butyrophilin (BTN) family interactions
metric value
setSize 10
pMANOVA 0.000771
p.adjustMANOVA 0.0045
s.dist 0.849
s.crp_pod1_adj -0.575
s.avb_pod1_adj -0.625
p.crp_pod1_adj 0.00164
p.avb_pod1_adj 0.000621



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
BTN2A2 -10892 -10072
BTN3A1 -10808 -9857
BTN2A1 -10543 -9338
CD209 -10416 -7735
BTN3A3 -7390 -5902
BTN3A2 -7555 -2901
BTN1A1 -7516 -1750

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
BTN1A1 -7516 -1750
BTN2A1 -10543 -9338
BTN2A2 -10892 -10072
BTN3A1 -10808 -9857
BTN3A2 -7555 -2901
BTN3A3 -7390 -5902
BTNL8 2440 -9197
BTNL9 -5641 1020
CD209 -10416 -7735
PPL 4345 -6594



Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of NIMA Kinases NEK9, NEK6, NEK7
metric value
setSize 7
pMANOVA 0.00457
p.adjustMANOVA 0.0199
s.dist 0.843
s.crp_pod1_adj 0.456
s.avb_pod1_adj 0.708
p.crp_pod1_adj 0.0365
p.avb_pod1_adj 0.00117



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
CDK1 8897 10881
CCNB1 7371 10139
NEK9 6395 9605
CCNB2 5317 9037
PLK1 5990 6725
NEK6 1416 321

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All member genes
crp_pod1_adj avb_pod1_adj
CCNB1 7371 10139
CCNB2 5317 9037
CDK1 8897 10881
NEK6 1416 321
NEK7 -3474 8806
NEK9 6395 9605
PLK1 5990 6725



Fructose catabolism
Fructose catabolism
metric value
setSize 5
pMANOVA 0.0286
p.adjustMANOVA 0.0821
s.dist 0.826
s.crp_pod1_adj -0.486
s.avb_pod1_adj -0.668
p.crp_pod1_adj 0.0597
p.avb_pod1_adj 0.00965



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
ALDH1A1 -10915 -10189
TKFC -10688 -10039
KHK -10573 -9273

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All member genes
crp_pod1_adj avb_pod1_adj
ALDH1A1 -10915 -10189
ALDOB 2371 67
GLYCTK 2531 -4043
KHK -10573 -9273
TKFC -10688 -10039



Regulation of IFNA/IFNB signaling
Regulation of IFNA/IFNB signaling
metric value
setSize 12
pMANOVA 0.000203
p.adjustMANOVA 0.00145
s.dist 0.81
s.crp_pod1_adj 0.441
s.avb_pod1_adj 0.679
p.crp_pod1_adj 0.0082
p.avb_pod1_adj 4.63e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
SOCS3 10320 10423
PTPN1 10157 10315
IFNAR2 9716 10359
SOCS1 10000 9116
IFNAR1 7766 10334
PTPN11 8724 8707
JAK1 4194 9178
PTPN6 7569 4480

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All member genes
crp_pod1_adj avb_pod1_adj
IFNAR1 7766 10334
IFNAR2 9716 10359
JAK1 4194 9178
PTPN1 10157 10315
PTPN11 8724 8707
PTPN6 7569 4480
SOCS1 10000 9116
SOCS3 10320 10423
STAT1 -2833 10930
STAT2 -5596 7383
TYK2 -448 -8652
USP18 -6868 8825



Type I hemidesmosome assembly
Type I hemidesmosome assembly
metric value
setSize 8
pMANOVA 0.00583
p.adjustMANOVA 0.0236
s.dist 0.806
s.crp_pod1_adj 0.566
s.avb_pod1_adj 0.574
p.crp_pod1_adj 0.0056
p.avb_pod1_adj 0.00492



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
LAMB3 10197 10947
ITGA6 9799 9697
KRT5 8074 11031
COL17A1 9113 9230
PLEC 8552 530
CD151 3763 1132
ITGB4 62 5191

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All member genes
crp_pod1_adj avb_pod1_adj
CD151 3763 1132
COL17A1 9113 9230
DST -3812 4269
ITGA6 9799 9697
ITGB4 62 5191
KRT5 8074 11031
LAMB3 10197 10947
PLEC 8552 530



Activation of caspases through apoptosome-mediated cleavage
Activation of caspases through apoptosome-mediated cleavage
metric value
setSize 6
pMANOVA 0.00184
p.adjustMANOVA 0.00958
s.dist 0.794
s.crp_pod1_adj 0.144
s.avb_pod1_adj 0.781
p.crp_pod1_adj 0.542
p.avb_pod1_adj 0.000926



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
XIAP 3594 10078
CASP3 2378 10567
CASP9 1584 9504
CYCS 2365 5790
APAF1 519 8944

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All member genes
crp_pod1_adj avb_pod1_adj
APAF1 519 8944
CASP3 2378 10567
CASP7 -3016 7311
CASP9 1584 9504
CYCS 2365 5790
XIAP 3594 10078



Inhibition of Signaling by Overexpressed EGFR
Inhibition of Signaling by Overexpressed EGFR
metric value
setSize 5
pMANOVA 0.000408
p.adjustMANOVA 0.00259
s.dist 0.78
s.crp_pod1_adj 0.753
s.avb_pod1_adj -0.202
p.crp_pod1_adj 0.00354
p.avb_pod1_adj 0.433



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
AREG 9309 -9301
EREG 9520 -8804
HBEGF 8211 -2493

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All member genes
crp_pod1_adj avb_pod1_adj
AREG 9309 -9301
EGF 1257 951
EREG 9520 -8804
HBEGF 8211 -2493
TGFA 10260 10923



Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
metric value
setSize 5
pMANOVA 0.000408
p.adjustMANOVA 0.00259
s.dist 0.78
s.crp_pod1_adj 0.753
s.avb_pod1_adj -0.202
p.crp_pod1_adj 0.00354
p.avb_pod1_adj 0.433



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
AREG 9309 -9301
EREG 9520 -8804
HBEGF 8211 -2493

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
AREG 9309 -9301
EGF 1257 951
EREG 9520 -8804
HBEGF 8211 -2493
TGFA 10260 10923



Establishment of Sister Chromatid Cohesion
Establishment of Sister Chromatid Cohesion
metric value
setSize 11
pMANOVA 0.000392
p.adjustMANOVA 0.00254
s.dist 0.77
s.crp_pod1_adj 0.344
s.avb_pod1_adj 0.689
p.crp_pod1_adj 0.0484
p.avb_pod1_adj 7.49e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
PDS5A 7491 9188
ESCO2 6015 10351
CDCA5 5346 9974
STAG2 4921 8934
SMC1A 7014 4346
STAG1 2355 7925
RAD21 2758 6486
WAPL 1716 7807
SMC3 1410 8597
PDS5B 418 2072

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
CDCA5 5346 9974
ESCO1 -2461 9327
ESCO2 6015 10351
PDS5A 7491 9188
PDS5B 418 2072
RAD21 2758 6486
SMC1A 7014 4346
SMC3 1410 8597
STAG1 2355 7925
STAG2 4921 8934
WAPL 1716 7807



Maturation of protein 3a_9683673
Maturation of protein 3a_9683673
metric value
setSize 9
pMANOVA 0.00446
p.adjustMANOVA 0.0196
s.dist 0.762
s.crp_pod1_adj 0.454
s.avb_pod1_adj 0.612
p.crp_pod1_adj 0.0184
p.avb_pod1_adj 0.00146



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
ST6GALNAC3 9452 9649
ST3GAL2 9439 9256
ST3GAL4 8037 9939
ST3GAL1 7899 5684
GALNT1 3114 10571
ST6GAL1 3630 5289
ST3GAL3 2068 2695

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All member genes
crp_pod1_adj avb_pod1_adj
GALNT1 3114 10571
ST3GAL1 7899 5684
ST3GAL2 9439 9256
ST3GAL3 2068 2695
ST3GAL4 8037 9939
ST6GAL1 3630 5289
ST6GALNAC2 -1795 6954
ST6GALNAC3 9452 9649
ST6GALNAC4 -1071 2151



Maturation of protein 3a_9694719
Maturation of protein 3a_9694719
metric value
setSize 9
pMANOVA 0.00446
p.adjustMANOVA 0.0196
s.dist 0.762
s.crp_pod1_adj 0.454
s.avb_pod1_adj 0.612
p.crp_pod1_adj 0.0184
p.avb_pod1_adj 0.00146



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
ST6GALNAC3 9452 9649
ST3GAL2 9439 9256
ST3GAL4 8037 9939
ST3GAL1 7899 5684
GALNT1 3114 10571
ST6GAL1 3630 5289
ST3GAL3 2068 2695

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All member genes
crp_pod1_adj avb_pod1_adj
GALNT1 3114 10571
ST3GAL1 7899 5684
ST3GAL2 9439 9256
ST3GAL3 2068 2695
ST3GAL4 8037 9939
ST6GAL1 3630 5289
ST6GALNAC2 -1795 6954
ST6GALNAC3 9452 9649
ST6GALNAC4 -1071 2151



ARMS-mediated activation
ARMS-mediated activation
metric value
setSize 6
pMANOVA 0.0165
p.adjustMANOVA 0.054
s.dist 0.761
s.crp_pod1_adj 0.351
s.avb_pod1_adj 0.676
p.crp_pod1_adj 0.136
p.avb_pod1_adj 0.00416



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
NTRK1 9393 10998
KIDINS220 6125 7455
BRAF 2325 5960
CRK 2710 4174
YWHAB 861 9771

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All member genes
crp_pod1_adj avb_pod1_adj
BRAF 2325 5960
CRK 2710 4174
KIDINS220 6125 7455
NTRK1 9393 10998
RAP1A -749 7133
YWHAB 861 9771



Acetylcholine binding and downstream events
Acetylcholine binding and downstream events
metric value
setSize 5
pMANOVA 0.0436
p.adjustMANOVA 0.112
s.dist 0.759
s.crp_pod1_adj 0.64
s.avb_pod1_adj 0.408
p.crp_pod1_adj 0.0132
p.avb_pod1_adj 0.114



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
CHRNA7 4920 8961
CHRNA5 5115 8554
CHRNE 4721 5805
CHRNA2 8983 2765

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All member genes
crp_pod1_adj avb_pod1_adj
CHRNA2 8983 2765
CHRNA5 5115 8554
CHRNA7 4920 8961
CHRNB2 8794 -2361
CHRNE 4721 5805



Postsynaptic nicotinic acetylcholine receptors
Postsynaptic nicotinic acetylcholine receptors
metric value
setSize 5
pMANOVA 0.0436
p.adjustMANOVA 0.112
s.dist 0.759
s.crp_pod1_adj 0.64
s.avb_pod1_adj 0.408
p.crp_pod1_adj 0.0132
p.avb_pod1_adj 0.114



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
CHRNA7 4920 8961
CHRNA5 5115 8554
CHRNE 4721 5805
CHRNA2 8983 2765

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All member genes
crp_pod1_adj avb_pod1_adj
CHRNA2 8983 2765
CHRNA5 5115 8554
CHRNA7 4920 8961
CHRNB2 8794 -2361
CHRNE 4721 5805



Neurotransmitter clearance
Neurotransmitter clearance
metric value
setSize 6
pMANOVA 0.00546
p.adjustMANOVA 0.0225
s.dist 0.755
s.crp_pod1_adj -0.192
s.avb_pod1_adj -0.73
p.crp_pod1_adj 0.416
p.avb_pod1_adj 0.00196



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
ALDH2 -7135 -10008
LRTOMT -6927 -7627
COMT -7796 -6623
MAOA -1422 -10058

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
ALDH2 -7135 -10008
COMT -7796 -6623
LRTOMT -6927 -7627
MAOA -1422 -10058
SLC22A1 3932 -9881
SLC6A4 5397 96



Protein repair
Protein repair
metric value
setSize 6
pMANOVA 0.0226
p.adjustMANOVA 0.0683
s.dist 0.751
s.crp_pod1_adj 0.383
s.avb_pod1_adj 0.646
p.crp_pod1_adj 0.105
p.avb_pod1_adj 0.0061



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
MSRB3 8105 8248
PCMT1 6266 9734
MSRB1 7547 7663
TXN 6040 9487

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All member genes
crp_pod1_adj avb_pod1_adj
MSRA -937 9730
MSRB1 7547 7663
MSRB2 -4374 -1226
MSRB3 8105 8248
PCMT1 6266 9734
TXN 6040 9487



Formation of xylulose-5-phosphate
Formation of xylulose-5-phosphate
metric value
setSize 5
pMANOVA 0.0156
p.adjustMANOVA 0.0521
s.dist 0.75
s.crp_pod1_adj -0.72
s.avb_pod1_adj -0.209
p.crp_pod1_adj 0.00528
p.avb_pod1_adj 0.418



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
AKR1A1 -7217 -6317
SORD -7095 -6385

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All member genes
crp_pod1_adj avb_pod1_adj
AKR1A1 -7217 -6317
CRYL1 -9133 486
DCXR -6143 2809
SORD -7095 -6385
XYLB -10123 326



Synthesis of diphthamide-EEF2
Synthesis of diphthamide-EEF2
metric value
setSize 8
pMANOVA 0.00719
p.adjustMANOVA 0.0283
s.dist 0.748
s.crp_pod1_adj -0.637
s.avb_pod1_adj -0.393
p.crp_pod1_adj 0.00181
p.avb_pod1_adj 0.0541



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
DPH7 -9744 -10154
DPH6 -10840 -8559
EEF2 -9782 -8827
DPH1 -8654 -8669
DPH2 -8411 -8875
DNAJC24 -10560 -4181

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
DNAJC24 -10560 -4181
DPH1 -8654 -8669
DPH2 -8411 -8875
DPH3 5248 10254
DPH5 -3684 8834
DPH6 -10840 -8559
DPH7 -9744 -10154
EEF2 -9782 -8827



NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulates pentose phosphate pathway genes
metric value
setSize 8
pMANOVA 0.00197
p.adjustMANOVA 0.0102
s.dist 0.734
s.crp_pod1_adj 0.701
s.avb_pod1_adj 0.218
p.crp_pod1_adj 0.000594
p.avb_pod1_adj 0.285



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
PGD 10160 10475
G6PD 8982 4583
MAFG 9975 1447
TALDO1 3056 3963
TKT 4470 1824
CREBBP 9117 214
EP300 8092 18

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All member genes
crp_pod1_adj avb_pod1_adj
CREBBP 9117 214
EP300 8092 18
G6PD 8982 4583
MAFG 9975 1447
NFE2L2 3414 -744
PGD 10160 10475
TALDO1 3056 3963
TKT 4470 1824



Formation of a pool of free 40S subunits
Formation of a pool of free 40S subunits
metric value
setSize 100
pMANOVA 4.02e-32
p.adjustMANOVA 1.29e-29
s.dist 0.733
s.crp_pod1_adj -0.686
s.avb_pod1_adj -0.258
p.crp_pod1_adj 1.71e-32
p.avb_pod1_adj 8.39e-06



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
EIF3B -7939 -9563
EIF3L -10568 -7036
RPL29 -9905 -7247
EIF3F -8955 -8001
EIF3G -8914 -7620
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047
RPL26 -9580 -4659

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF1AX -4224 3200
EIF3A -5698 -1013
EIF3B -7939 -9563
EIF3C -7727 -4979
EIF3D -8646 -2349
EIF3E -9990 -1990
EIF3F -8955 -8001
EIF3G -8914 -7620
EIF3H -8454 -1951
EIF3I -5939 1862
EIF3J -6194 9053
EIF3K -8872 -3989
EIF3L -10568 -7036
EIF3M -10593 -2957
FAU -7843 -4782
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Peptide chain elongation
Peptide chain elongation
metric value
setSize 88
pMANOVA 4.71e-28
p.adjustMANOVA 6.46e-26
s.dist 0.732
s.crp_pod1_adj -0.683
s.avb_pod1_adj -0.263
p.crp_pod1_adj 1.39e-28
p.avb_pod1_adj 2.04e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
EEF2 -9782 -8827
RPL29 -9905 -7247
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EEF1A1 -10245 -5368
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047
RPL26 -9580 -4659
RPL30 -8665 -4964
RPL39 -8078 -5172

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All member genes
crp_pod1_adj avb_pod1_adj
EEF1A1 -10245 -5368
EEF2 -9782 -8827
FAU -7843 -4782
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Interleukin-21 signaling
Interleukin-21 signaling
metric value
setSize 9
pMANOVA 0.00295
p.adjustMANOVA 0.0139
s.dist 0.731
s.crp_pod1_adj 0.321
s.avb_pod1_adj 0.657
p.crp_pod1_adj 0.0958
p.avb_pod1_adj 0.000646



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
JAK3 10262 10661
IL21R 9601 10245
STAT3 9918 9903
JAK1 4194 9178
STAT5B 3275 3345

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All member genes
crp_pod1_adj avb_pod1_adj
IL21R 9601 10245
IL2RG -3583 8060
JAK1 4194 9178
JAK3 10262 10661
STAT1 -2833 10930
STAT3 9918 9903
STAT4 -4500 6554
STAT5A 1714 -2455
STAT5B 3275 3345



Mitotic Telophase/Cytokinesis
Mitotic Telophase/Cytokinesis
metric value
setSize 13
pMANOVA 0.00104
p.adjustMANOVA 0.00584
s.dist 0.721
s.crp_pod1_adj 0.448
s.avb_pod1_adj 0.565
p.crp_pod1_adj 0.00516
p.avb_pod1_adj 0.000422



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
KIF20A 8698 10172
PDS5A 7491 9188
NIPBL 6805 8208
STAG2 4921 8934
PLK1 5990 6725
SMC1A 7014 4346
KIF23 4863 5801
STAG1 2355 7925
RAD21 2758 6486
WAPL 1716 7807
SMC3 1410 8597
PDS5B 418 2072

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
KIF20A 8698 10172
KIF23 4863 5801
MAU2 3650 -3031
NIPBL 6805 8208
PDS5A 7491 9188
PDS5B 418 2072
PLK1 5990 6725
RAD21 2758 6486
SMC1A 7014 4346
SMC3 1410 8597
STAG1 2355 7925
STAG2 4921 8934
WAPL 1716 7807



Eukaryotic Translation Elongation
Eukaryotic Translation Elongation
metric value
setSize 93
pMANOVA 1.14e-28
p.adjustMANOVA 1.82e-26
s.dist 0.718
s.crp_pod1_adj -0.671
s.avb_pod1_adj -0.254
p.crp_pod1_adj 3.95e-29
p.avb_pod1_adj 2.31e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
EEF2 -9782 -8827
RPL29 -9905 -7247
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EEF1A1 -10245 -5368
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047
RPL26 -9580 -4659
RPL30 -8665 -4964
RPL39 -8078 -5172

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EEF1A1 -10245 -5368
EEF1A1P5 -9368 -1604
EEF1A2 4434 3247
EEF1B2 -8023 -1753
EEF1D -6126 -2737
EEF1G -6690 -353
EEF2 -9782 -8827
FAU -7843 -4782
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Selenocysteine synthesis
Selenocysteine synthesis
metric value
setSize 92
pMANOVA 5.14e-28
p.adjustMANOVA 6.58e-26
s.dist 0.711
s.crp_pod1_adj -0.666
s.avb_pod1_adj -0.248
p.crp_pod1_adj 2.01e-28
p.avb_pod1_adj 4.03e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
RPL29 -9905 -7247
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
SEPSECS -9022 -5255
RPL18A -8223 -5642
RPL15 -8846 -5047
RPL26 -9580 -4659
RPL30 -8665 -4964
RPL39 -8078 -5172
RPL38 -7530 -5204

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EEFSEC -5940 -6576
FAU -7843 -4782
PSTK -6973 -1014
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
SARS1 -6275 -267
SECISBP2 -9328 -4050
SEPHS2 4069 8151
SEPSECS -9022 -5255
UBA52 -8729 -4307



SARS-CoV-1 modulates host translation machinery
SARS-CoV-1 modulates host translation machinery
metric value
setSize 36
pMANOVA 5.45e-11
p.adjustMANOVA 1.29e-09
s.dist 0.708
s.crp_pod1_adj -0.656
s.avb_pod1_adj -0.266
p.crp_pod1_adj 9.12e-12
p.avb_pod1_adj 0.00574



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EEF1A1 -10245 -5368
RPS2 -7645 -6568
RPS16 -7012 -6856
FAU -7843 -4782
RPS28 -7102 -4932
RPS15 -7592 -4423
RPS10 -8578 -3550
RPS3 -9260 -3259
RPS20 -9205 -2819
RPS5 -5787 -4156
RPS3A -9507 -2359
RPS23 -7122 -2904
RPS27A -8697 -1975
RPS21 -6334 -2295
RPS18 -6316 -1924

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EEF1A1 -10245 -5368
FAU -7843 -4782
HNRNPA1 -7206 -1349
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812



Viral mRNA Translation
Viral mRNA Translation
metric value
setSize 88
pMANOVA 2.32e-26
p.adjustMANOVA 2.12e-24
s.dist 0.697
s.crp_pod1_adj -0.658
s.avb_pod1_adj -0.232
p.crp_pod1_adj 1.31e-26
p.avb_pod1_adj 0.000168



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
RPL29 -9905 -7247
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047
RPL26 -9580 -4659
RPL30 -8665 -4964
RPL39 -8078 -5172
RPL38 -7530 -5204
UBA52 -8729 -4307

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
DNAJC3 10014 9985
FAU -7843 -4782
GRSF1 -6338 4335
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Eukaryotic Translation Termination
Eukaryotic Translation Termination
metric value
setSize 92
pMANOVA 2.95e-27
p.adjustMANOVA 3.15e-25
s.dist 0.694
s.crp_pod1_adj -0.655
s.avb_pod1_adj -0.232
p.crp_pod1_adj 1.7e-27
p.avb_pod1_adj 0.000121



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
RPL29 -9905 -7247
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
N6AMT1 -9592 -4700
RPL15 -8846 -5047
RPL26 -9580 -4659
RPL30 -8665 -4964
RPL39 -8078 -5172
RPL38 -7530 -5204

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
APEH -5934 -4396
ETF1 1864 2844
FAU -7843 -4782
GSPT1 2489 4986
GSPT2 -4177 8082
N6AMT1 -9592 -4700
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
TRMT112 -6824 -465
UBA52 -8729 -4307



EGFR interacts with phospholipase C-gamma
EGFR interacts with phospholipase C-gamma
metric value
setSize 6
pMANOVA 0.000451
p.adjustMANOVA 0.00284
s.dist 0.692
s.crp_pod1_adj 0.655
s.avb_pod1_adj -0.224
p.crp_pod1_adj 0.00549
p.avb_pod1_adj 0.342



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
AREG 9309 -9301
EREG 9520 -8804
HBEGF 8211 -2493
PLCG1 1429 -3112

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
AREG 9309 -9301
EGF 1257 951
EREG 9520 -8804
HBEGF 8211 -2493
PLCG1 1429 -3112
TGFA 10260 10923



Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
metric value
setSize 5
pMANOVA 0.0884
p.adjustMANOVA 0.187
s.dist 0.687
s.crp_pod1_adj 0.418
s.avb_pod1_adj 0.546
p.crp_pod1_adj 0.106
p.avb_pod1_adj 0.0345



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
GAS6 10268 10294
PROC 6087 10374
PROS1 5795 9526
PROZ 3237 941

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
BGLAP -4631 -114
GAS6 10268 10294
PROC 6087 10374
PROS1 5795 9526
PROZ 3237 941



RUNX3 regulates CDKN1A transcription
RUNX3 regulates CDKN1A transcription
metric value
setSize 7
pMANOVA 0.0302
p.adjustMANOVA 0.0861
s.dist 0.685
s.crp_pod1_adj -0.383
s.avb_pod1_adj -0.568
p.crp_pod1_adj 0.0795
p.avb_pod1_adj 0.0093



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
TP53 -10249 -9050
SMAD3 -7857 -9751
TGFB1 -8343 -7343
ZFHX3 -5156 -8881

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
CDKN1A 6185 -8616
RUNX3 259 -1163
SMAD3 -7857 -9751
SMAD4 -5325 5430
TGFB1 -8343 -7343
TP53 -10249 -9050
ZFHX3 -5156 -8881



Platelet sensitization by LDL
Platelet sensitization by LDL
metric value
setSize 16
pMANOVA 0.000521
p.adjustMANOVA 0.00318
s.dist 0.685
s.crp_pod1_adj 0.436
s.avb_pod1_adj 0.527
p.crp_pod1_adj 0.0025
p.avb_pod1_adj 0.000259



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
MAPK14 10146 10644
FGR 10011 10344
LRP8 10221 7523
PTPN11 8724 8707
PECAM1 4394 9657
PTPN6 7569 4480
PPP2R1B 4670 6069
PPP2CA 3126 7334
PPP2R5A 3064 7028
PPP2R5E 3522 5369
PLA2G4A 7100 2553
PPP2R5D 3887 3701
PPP2R5B 6607 1596

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
FGR 10011 10344
LRP8 10221 7523
MAPK14 10146 10644
PECAM1 4394 9657
PLA2G4A 7100 2553
PPP2CA 3126 7334
PPP2CB -5595 3553
PPP2R1A -2420 963
PPP2R1B 4670 6069
PPP2R5A 3064 7028
PPP2R5B 6607 1596
PPP2R5C -5494 6557
PPP2R5D 3887 3701
PPP2R5E 3522 5369
PTPN11 8724 8707
PTPN6 7569 4480



Interleukin-6 signaling
Interleukin-6 signaling
metric value
setSize 10
pMANOVA 0.00474
p.adjustMANOVA 0.0204
s.dist 0.683
s.crp_pod1_adj 0.332
s.avb_pod1_adj 0.597
p.crp_pod1_adj 0.069
p.avb_pod1_adj 0.00108



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
SOCS3 10320 10423
STAT3 9918 9903
IL6ST 7943 10321
PTPN11 8724 8707
JAK1 4194 9178
CBL 4108 6597

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
CBL 4108 6597
IL6R -2315 5911
IL6ST 7943 10321
JAK1 4194 9178
JAK2 -7227 4114
PTPN11 8724 8707
SOCS3 10320 10423
STAT1 -2833 10930
STAT3 9918 9903
TYK2 -448 -8652



RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in BCR signaling
metric value
setSize 6
pMANOVA 0.0428
p.adjustMANOVA 0.111
s.dist 0.682
s.crp_pod1_adj 0.59
s.avb_pod1_adj 0.342
p.crp_pod1_adj 0.0123
p.avb_pod1_adj 0.147



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RUNX1 10315 10754
CBFB 4971 9469
PAX5 7274 1626
ELF1 1383 4733
ELF2 4102 1175

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
BLK 7828 -3513
CBFB 4971 9469
ELF1 1383 4733
ELF2 4102 1175
PAX5 7274 1626
RUNX1 10315 10754



Removal of aminoterminal propeptides from gamma-carboxylated proteins
Removal of aminoterminal propeptides from gamma-carboxylated proteins
metric value
setSize 6
pMANOVA 0.0633
p.adjustMANOVA 0.147
s.dist 0.679
s.crp_pod1_adj 0.506
s.avb_pod1_adj 0.453
p.crp_pod1_adj 0.0317
p.avb_pod1_adj 0.0548



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
GAS6 10268 10294
PROC 6087 10374
PROS1 5795 9526
PROZ 3237 941
FURIN 9787 271

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
BGLAP -4631 -114
FURIN 9787 271
GAS6 10268 10294
PROC 6087 10374
PROS1 5795 9526
PROZ 3237 941



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 94
pMANOVA 2.98e-26
p.adjustMANOVA 2.61e-24
s.dist 0.679
s.crp_pod1_adj -0.637
s.avb_pod1_adj -0.235
p.crp_pod1_adj 1.16e-26
p.avb_pod1_adj 8.33e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
NCBP2 -10422 -9777
RPS4Y1 -9472 -9681
RPL29 -9905 -7247
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047
RPL26 -9580 -4659
RPL30 -8665 -4964
RPL39 -8078 -5172
RPL38 -7530 -5204

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF4G1 9201 -2286
ETF1 1864 2844
FAU -7843 -4782
GSPT1 2489 4986
GSPT2 -4177 8082
NCBP1 -6313 -1775
NCBP2 -10422 -9777
PABPC1 -10239 2209
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307
UPF1 -1566 -4925



L13a-mediated translational silencing of Ceruloplasmin expression
L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 110
pMANOVA 1.93e-31
p.adjustMANOVA 4.12e-29
s.dist 0.679
s.crp_pod1_adj -0.642
s.avb_pod1_adj -0.219
p.crp_pod1_adj 2.14e-31
p.avb_pod1_adj 7.19e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
EIF3B -7939 -9563
EIF3L -10568 -7036
RPL29 -9905 -7247
EIF3F -8955 -8001
EIF3G -8914 -7620
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EIF4A1 -6442 -8201
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF1AX -4224 3200
EIF2S1 1134 7682
EIF2S2 1009 8897
EIF2S3 -8440 5447
EIF3A -5698 -1013
EIF3B -7939 -9563
EIF3C -7727 -4979
EIF3D -8646 -2349
EIF3E -9990 -1990
EIF3F -8955 -8001
EIF3G -8914 -7620
EIF3H -8454 -1951
EIF3I -5939 1862
EIF3J -6194 9053
EIF3K -8872 -3989
EIF3L -10568 -7036
EIF3M -10593 -2957
EIF4A1 -6442 -8201
EIF4A2 -6158 561
EIF4B -10332 -2483
EIF4E 7774 9581
EIF4G1 9201 -2286
EIF4H -1997 517
FAU -7843 -4782
PABPC1 -10239 2209
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Formation of the ternary complex, and subsequently, the 43S complex
Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 51
pMANOVA 4.41e-15
p.adjustMANOVA 1.77e-13
s.dist 0.679
s.crp_pod1_adj -0.644
s.avb_pod1_adj -0.215
p.crp_pod1_adj 1.77e-15
p.avb_pod1_adj 0.00789



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
EIF3B -7939 -9563
EIF3L -10568 -7036
EIF3F -8955 -8001
EIF3G -8914 -7620
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
RPS2 -7645 -6568
RPS16 -7012 -6856
EIF3C -7727 -4979
FAU -7843 -4782
EIF3K -8872 -3989
RPS28 -7102 -4932
RPS15 -7592 -4423
EIF3M -10593 -2957
RPS10 -8578 -3550
RPS3 -9260 -3259
RPS20 -9205 -2819

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF1AX -4224 3200
EIF2S1 1134 7682
EIF2S2 1009 8897
EIF2S3 -8440 5447
EIF3A -5698 -1013
EIF3B -7939 -9563
EIF3C -7727 -4979
EIF3D -8646 -2349
EIF3E -9990 -1990
EIF3F -8955 -8001
EIF3G -8914 -7620
EIF3H -8454 -1951
EIF3I -5939 1862
EIF3J -6194 9053
EIF3K -8872 -3989
EIF3L -10568 -7036
EIF3M -10593 -2957
FAU -7843 -4782
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812



Scavenging by Class F Receptors
Scavenging by Class F Receptors
metric value
setSize 5
pMANOVA 0.105
p.adjustMANOVA 0.213
s.dist 0.674
s.crp_pod1_adj 0.487
s.avb_pod1_adj 0.466
p.crp_pod1_adj 0.0594
p.avb_pod1_adj 0.0711



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
CALR 10166 10614
HYOU1 9974 10399
HSPH1 8395 7987
HSP90AA1 6767 7945

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
CALR 10166 10614
HSP90AA1 6767 7945
HSPH1 8395 7987
HYOU1 9974 10399
SCARF1 -10882 -10162



Ethanol oxidation
Ethanol oxidation
metric value
setSize 6
pMANOVA 0.052
p.adjustMANOVA 0.127
s.dist 0.672
s.crp_pod1_adj -0.568
s.avb_pod1_adj -0.358
p.crp_pod1_adj 0.016
p.avb_pod1_adj 0.129



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
ALDH1A1 -10915 -10189
ACSS1 -10346 -9669
ALDH2 -7135 -10008
ALDH1B1 -7209 -439

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
ACSS1 -10346 -9669
ACSS2 7954 5299
ADH5 -10292 4597
ALDH1A1 -10915 -10189
ALDH1B1 -7209 -439
ALDH2 -7135 -10008



MET activates PI3K/AKT signaling
MET activates PI3K/AKT signaling
metric value
setSize 5
pMANOVA 0.11
p.adjustMANOVA 0.217
s.dist 0.668
s.crp_pod1_adj 0.486
s.avb_pod1_adj 0.458
p.crp_pod1_adj 0.0599
p.avb_pod1_adj 0.0762



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
HGF 8594 10493
PIK3CA 5469 8891
PIK3R1 5072 5606
GRB2 6102 4488

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
GAB1 -877 -3127
GRB2 6102 4488
HGF 8594 10493
PIK3CA 5469 8891
PIK3R1 5072 5606



RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
metric value
setSize 7
pMANOVA 0.0457
p.adjustMANOVA 0.116
s.dist 0.667
s.crp_pod1_adj 0.459
s.avb_pod1_adj 0.483
p.crp_pod1_adj 0.0353
p.avb_pod1_adj 0.0268



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RUNX1 10315 10754
SOCS3 10320 10423
CTSL 10248 10031
CBFB 4971 9469
CTSV 8836 434

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
CBFB 4971 9469
CTSK -8365 -7560
CTSL 10248 10031
CTSV 8836 434
RUNX1 10315 10754
SOCS3 10320 10423
SOCS4 -4194 5223



GTP hydrolysis and joining of the 60S ribosomal subunit
GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 111
pMANOVA 1.45e-30
p.adjustMANOVA 2.54e-28
s.dist 0.666
s.crp_pod1_adj -0.63
s.avb_pod1_adj -0.214
p.crp_pod1_adj 1.55e-30
p.avb_pod1_adj 9.5e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
RPS4Y1 -9472 -9681
EIF3B -7939 -9563
EIF3L -10568 -7036
RPL29 -9905 -7247
EIF3F -8955 -8001
EIF3G -8914 -7620
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EIF4A1 -6442 -8201
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
RPL10 -9193 -5253
RPS16 -7012 -6856
RPL18A -8223 -5642
RPL15 -8846 -5047

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF1AX -4224 3200
EIF2S1 1134 7682
EIF2S2 1009 8897
EIF2S3 -8440 5447
EIF3A -5698 -1013
EIF3B -7939 -9563
EIF3C -7727 -4979
EIF3D -8646 -2349
EIF3E -9990 -1990
EIF3F -8955 -8001
EIF3G -8914 -7620
EIF3H -8454 -1951
EIF3I -5939 1862
EIF3J -6194 9053
EIF3K -8872 -3989
EIF3L -10568 -7036
EIF3M -10593 -2957
EIF4A1 -6442 -8201
EIF4A2 -6158 561
EIF4B -10332 -2483
EIF4E 7774 9581
EIF4G1 9201 -2286
EIF4H -1997 517
EIF5 -1825 -1518
EIF5B -1182 7287
FAU -7843 -4782
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Cap-dependent Translation Initiation
Cap-dependent Translation Initiation
metric value
setSize 118
pMANOVA 7.6e-32
p.adjustMANOVA 1.83e-29
s.dist 0.665
s.crp_pod1_adj -0.626
s.avb_pod1_adj -0.222
p.crp_pod1_adj 5.65e-32
p.avb_pod1_adj 2.98e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
EIF4EBP1 -9923 -9473
RPS4Y1 -9472 -9681
EIF2B1 -10174 -8234
EIF3B -7939 -9563
EIF3L -10568 -7036
RPL29 -9905 -7247
EIF3F -8955 -8001
EIF3G -8914 -7620
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EIF4A1 -6442 -8201
EIF2B4 -6196 -8118
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
EIF2B5 -5246 -9412

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF1AX -4224 3200
EIF2B1 -10174 -8234
EIF2B2 2557 4443
EIF2B3 -4327 5610
EIF2B4 -6196 -8118
EIF2B5 -5246 -9412
EIF2S1 1134 7682
EIF2S2 1009 8897
EIF2S3 -8440 5447
EIF3A -5698 -1013
EIF3B -7939 -9563
EIF3C -7727 -4979
EIF3D -8646 -2349
EIF3E -9990 -1990
EIF3F -8955 -8001
EIF3G -8914 -7620
EIF3H -8454 -1951
EIF3I -5939 1862
EIF3J -6194 9053
EIF3K -8872 -3989
EIF3L -10568 -7036
EIF3M -10593 -2957
EIF4A1 -6442 -8201
EIF4A2 -6158 561
EIF4B -10332 -2483
EIF4E 7774 9581
EIF4EBP1 -9923 -9473
EIF4G1 9201 -2286
EIF4H -1997 517
EIF5 -1825 -1518
EIF5B -1182 7287
FAU -7843 -4782
PABPC1 -10239 2209
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Eukaryotic Translation Initiation
Eukaryotic Translation Initiation
metric value
setSize 118
pMANOVA 7.6e-32
p.adjustMANOVA 1.83e-29
s.dist 0.665
s.crp_pod1_adj -0.626
s.avb_pod1_adj -0.222
p.crp_pod1_adj 5.65e-32
p.avb_pod1_adj 2.98e-05



Top 20 genes
Gene crp_pod1_adj avb_pod1_adj
EIF4EBP1 -9923 -9473
RPS4Y1 -9472 -9681
EIF2B1 -10174 -8234
EIF3B -7939 -9563
EIF3L -10568 -7036
RPL29 -9905 -7247
EIF3F -8955 -8001
EIF3G -8914 -7620
RPL39L -9834 -6784
RPL8 -8894 -7395
RPS4X -10154 -6343
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS11 -8836 -6481
EIF4A1 -6442 -8201
EIF2B4 -6196 -8118
RPS2 -7645 -6568
RPL34 -9464 -5303
RPL18 -9365 -5291
EIF2B5 -5246 -9412

Click HERE to show all gene set members

All member genes
crp_pod1_adj avb_pod1_adj
EIF1AX -4224 3200
EIF2B1 -10174 -8234
EIF2B2 2557 4443
EIF2B3 -4327 5610
EIF2B4 -6196 -8118
EIF2B5 -5246 -9412
EIF2S1 1134 7682
EIF2S2 1009 8897
EIF2S3 -8440 5447
EIF3A -5698 -1013
EIF3B -7939 -9563
EIF3C -7727 -4979
EIF3D -8646 -2349
EIF3E -9990 -1990
EIF3F -8955 -8001
EIF3G -8914 -7620
EIF3H -8454 -1951
EIF3I -5939 1862
EIF3J -6194 9053
EIF3K -8872 -3989
EIF3L -10568 -7036
EIF3M -10593 -2957
EIF4A1 -6442 -8201
EIF4A2 -6158 561
EIF4B -10332 -2483
EIF4E 7774 9581
EIF4EBP1 -9923 -9473
EIF4G1 9201 -2286
EIF4H -1997 517
EIF5 -1825 -1518
EIF5B -1182 7287
FAU -7843 -4782
PABPC1 -10239 2209
RPL10 -9193 -5253
RPL10A -8093 -1307
RPL11 -8932 -2548
RPL12 -8971 2346
RPL13 -5801 2495
RPL13A -8632 -4076
RPL14 -8257 516
RPL15 -8846 -5047
RPL17 -8359 55
RPL18 -9365 -5291
RPL18A -8223 -5642
RPL19 -8300 -2523
RPL21 -8575 -1147
RPL22 -9058 53
RPL22L1 -9402 588
RPL23 -7851 -1588
RPL23A -8695 -3429
RPL24 -8009 789
RPL26 -9580 -4659
RPL26L1 1524 3887
RPL27 -7255 -1575
RPL27A -7212 1505
RPL28 -6550 -2887
RPL29 -9905 -7247
RPL3 -8725 -4142
RPL30 -8665 -4964
RPL31 -8380 -3555
RPL32 -7813 -3300
RPL34 -9464 -5303
RPL35 -5324 -2759
RPL35A -9421 -2172
RPL36 -5842 -3274
RPL36A -8635 -3424
RPL36AL 321 3619
RPL37 -6639 -4071
RPL37A -6495 -2068
RPL38 -7530 -5204
RPL39 -8078 -5172
RPL39L -9834 -6784
RPL3L -8254 7411
RPL4 -9637 -2951
RPL41 -6731 -223
RPL5 -9353 -1358
RPL6 -8995 -1106
RPL7 -9553 -2258
RPL7A -9040 -2732
RPL8 -8894 -7395
RPL9 460 1781
RPLP0 -5840 -3023
RPLP1 -4244 -547
RPLP2 -6981 -3224
RPS10 -8578 -3550
RPS11 -8836 -6481
RPS12 -7527 -558
RPS13 -10047 -5789
RPS14 -8301 -6977
RPS15 -7592 -4423
RPS15A -7215 -1173
RPS16 -7012 -6856
RPS17 -4935 -158
RPS18 -6316 -1924
RPS19 -6357 -1557
RPS2 -7645 -6568
RPS20 -9205 -2819
RPS21 -6334 -2295
RPS23 -7122 -2904
RPS24 -8168 -985
RPS25 -8214 288
RPS26 6287 3300
RPS27 -6034 -1764
RPS27A -8697 -1975
RPS27L -7877 4922
RPS28 -7102 -4932
RPS29 -2896 -973
RPS3 -9260 -3259
RPS3A -9507 -2359
RPS4X -10154 -6343
RPS4Y1 -9472 -9681
RPS5 -5787 -4156
RPS6 -7638 2674
RPS7 -9302 -295
RPS8 -7537 -945
RPS9 -4833 4180
RPSA -6608 812
UBA52 -8729 -4307



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report