date generated: 2024-11-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
crp_t0_adj avb_t0_adj
5_8S_rRNA -0.6891322 -1.6447949
A1BG 0.2163555 0.7426509
A1BG-AS1 -0.4425330 0.1261025
A1CF -0.5935004 -0.0456164
A2M 1.2986453 -1.6576434
A2M-AS1 0.4479278 -2.2029246

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 21870
duplicated_genes_present 0
num_profile_genes_in_sets 8802
num_profile_genes_not_in_sets 13068
profile_pearson_correl 0.39651
profile_spearman_correl 0.39836

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1189
num_genesets_included 1536

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 609

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.crp_t0_adj s.avb_t0_adj p.crp_t0_adj p.avb_t0_adj
Regulation of NFE2L2 gene expression 8 6.81e-05 6.00e-04 1.030 0.5830 0.85400 0.00428 2.87e-05
NFE2L2 regulating inflammation associated genes 5 1.60e-02 5.05e-02 0.840 0.4150 0.73000 0.10800 4.68e-03
CYP2E1 reactions 5 2.02e-02 6.05e-02 0.839 0.4900 0.68100 0.05780 8.36e-03
MECP2 regulates transcription of neuronal ligands 5 1.35e-02 4.38e-02 0.809 0.2840 0.75700 0.27200 3.36e-03
Phosphorylation of Emi1 6 7.27e-03 2.65e-02 0.770 0.2250 0.73600 0.33900 1.79e-03
Diseases of Base Excision Repair 5 3.84e-02 9.66e-02 0.766 0.4460 0.62300 0.08440 1.58e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 4.99e-04 3.15e-03 0.759 -0.0548 0.75700 0.80200 5.22e-04
Interleukin-21 signaling 9 1.07e-03 5.76e-03 0.749 0.2370 0.71000 0.21800 2.25e-04
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 3.77e-03 1.59e-02 0.718 0.1220 0.70800 0.57700 1.18e-03
Phosphate bond hydrolysis by NTPDase proteins 5 9.55e-03 3.32e-02 0.711 -0.7100 0.02940 0.00596 9.10e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.00e-02 3.47e-02 0.699 -0.0499 0.69700 0.84700 6.93e-03
Wax and plasmalogen biosynthesis 5 4.77e-02 1.14e-01 0.695 -0.6370 -0.27900 0.01370 2.81e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 4.80e-02 1.14e-01 0.692 -0.6360 -0.27300 0.01380 2.91e-01
Protein repair 6 4.80e-02 1.14e-01 0.685 -0.5170 -0.44900 0.02820 5.70e-02
H139Hfs13* PPM1K causes a mild variant of MSUD 5 7.40e-02 1.52e-01 0.682 -0.5620 -0.38600 0.02950 1.35e-01
Maple Syrup Urine Disease 5 7.40e-02 1.52e-01 0.682 -0.5620 -0.38600 0.02950 1.35e-01
POLB-Dependent Long Patch Base Excision Repair 8 4.35e-03 1.78e-02 0.680 0.1550 0.66300 0.44900 1.17e-03
Abacavir ADME 5 7.67e-02 1.57e-01 0.675 0.5620 0.37400 0.02950 1.48e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.75e-02 5.41e-02 0.673 -0.6730 0.00202 0.00918 9.94e-01
Calcitonin-like ligand receptors 5 5.54e-02 1.26e-01 0.666 0.6210 0.24100 0.01610 3.50e-01
SUMO is proteolytically processed 6 7.15e-03 2.63e-02 0.653 -0.6490 0.06920 0.00589 7.69e-01
Acetylcholine binding and downstream events 5 7.02e-02 1.47e-01 0.650 0.2620 0.59500 0.31000 2.13e-02
Postsynaptic nicotinic acetylcholine receptors 5 7.02e-02 1.47e-01 0.650 0.2620 0.59500 0.31000 2.13e-02
Formation of the ureteric bud 5 1.00e-01 1.91e-01 0.647 -0.3920 -0.51500 0.12900 4.63e-02
Phosphate bond hydrolysis by NUDT proteins 7 2.48e-02 6.94e-02 0.645 -0.5930 -0.25300 0.00658 2.47e-01
Disorders of Developmental Biology 12 8.56e-04 4.88e-03 0.639 0.1590 0.61900 0.34100 2.04e-04
Disorders of Nervous System Development 12 8.56e-04 4.88e-03 0.639 0.1590 0.61900 0.34100 2.04e-04
Loss of function of MECP2 in Rett syndrome 12 8.56e-04 4.88e-03 0.639 0.1590 0.61900 0.34100 2.04e-04
Pervasive developmental disorders 12 8.56e-04 4.88e-03 0.639 0.1590 0.61900 0.34100 2.04e-04
Eicosanoids 8 1.80e-03 8.59e-03 0.639 0.0688 -0.63500 0.73600 1.86e-03
NFE2L2 regulating MDR associated enzymes 8 2.88e-02 7.72e-02 0.639 0.4050 0.49500 0.04760 1.54e-02
Unwinding of DNA 12 4.33e-03 1.78e-02 0.638 0.3670 0.52200 0.02770 1.74e-03
PTK6 promotes HIF1A stabilization 6 7.26e-02 1.51e-01 0.638 -0.4710 -0.42900 0.04560 6.86e-02
Type I hemidesmosome assembly 8 1.31e-02 4.27e-02 0.623 0.1770 0.59800 0.38600 3.42e-03
PDH complex synthesizes acetyl-CoA from PYR 5 8.35e-02 1.68e-01 0.623 -0.5750 -0.23800 0.02590 3.57e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.76e-03 8.43e-03 0.614 -0.1420 0.59800 0.48700 3.42e-03
Activation of caspases through apoptosome-mediated cleavage 6 3.11e-02 8.24e-02 0.609 -0.6010 -0.09580 0.01080 6.84e-01
Defective LFNG causes SCDO3 5 4.12e-02 1.02e-01 0.605 0.0181 0.60500 0.94400 1.91e-02
Repression of WNT target genes 14 4.09e-03 1.70e-02 0.600 0.3720 0.47100 0.01590 2.30e-03
Interleukin-9 signaling 8 2.31e-02 6.62e-02 0.596 0.2050 0.56000 0.31600 6.08e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.97e-03 1.31e-02 0.590 -0.5880 -0.04670 0.00127 7.98e-01
Estrogen-stimulated signaling through PRKCZ 6 4.60e-02 1.11e-01 0.582 -0.5710 -0.11000 0.01540 6.39e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 3.86e-02 9.67e-02 0.578 0.1660 0.55400 0.44700 1.12e-02
Small interfering RNA (siRNA) biogenesis 9 1.16e-02 3.88e-02 0.577 -0.5640 -0.12300 0.00338 5.21e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 8.90e-10 2.81e-08 0.577 -0.0718 0.57200 0.48200 2.08e-08
Formyl peptide receptors bind formyl peptides and many other ligands 7 6.82e-02 1.44e-01 0.576 -0.4950 -0.29400 0.02340 1.78e-01
Formation of xylulose-5-phosphate 5 4.87e-02 1.15e-01 0.570 -0.5690 0.03170 0.02760 9.02e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.85e-02 1.31e-01 0.570 0.5190 0.23500 0.01740 2.82e-01
Activation of PUMA and translocation to mitochondria 9 2.17e-02 6.31e-02 0.568 0.1980 0.53300 0.30300 5.66e-03
Activation of the AP-1 family of transcription factors 10 3.18e-02 8.31e-02 0.567 -0.4110 -0.39000 0.02430 3.27e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.crp_t0_adj s.avb_t0_adj p.crp_t0_adj p.avb_t0_adj
Regulation of NFE2L2 gene expression 8 6.81e-05 6.00e-04 1.0300 5.83e-01 0.854000 4.28e-03 2.87e-05
NFE2L2 regulating inflammation associated genes 5 1.60e-02 5.05e-02 0.8400 4.15e-01 0.730000 1.08e-01 4.68e-03
CYP2E1 reactions 5 2.02e-02 6.05e-02 0.8390 4.90e-01 0.681000 5.78e-02 8.36e-03
MECP2 regulates transcription of neuronal ligands 5 1.35e-02 4.38e-02 0.8090 2.84e-01 0.757000 2.72e-01 3.36e-03
Phosphorylation of Emi1 6 7.27e-03 2.65e-02 0.7700 2.25e-01 0.736000 3.39e-01 1.79e-03
Diseases of Base Excision Repair 5 3.84e-02 9.66e-02 0.7660 4.46e-01 0.623000 8.44e-02 1.58e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 4.99e-04 3.15e-03 0.7590 -5.48e-02 0.757000 8.02e-01 5.22e-04
Interleukin-21 signaling 9 1.07e-03 5.76e-03 0.7490 2.37e-01 0.710000 2.18e-01 2.25e-04
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 3.77e-03 1.59e-02 0.7180 1.22e-01 0.708000 5.77e-01 1.18e-03
Phosphate bond hydrolysis by NTPDase proteins 5 9.55e-03 3.32e-02 0.7110 -7.10e-01 0.029400 5.96e-03 9.10e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.00e-02 3.47e-02 0.6990 -4.99e-02 0.697000 8.47e-01 6.93e-03
Wax and plasmalogen biosynthesis 5 4.77e-02 1.14e-01 0.6950 -6.37e-01 -0.279000 1.37e-02 2.81e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 4.80e-02 1.14e-01 0.6920 -6.36e-01 -0.273000 1.38e-02 2.91e-01
Protein repair 6 4.80e-02 1.14e-01 0.6850 -5.17e-01 -0.449000 2.82e-02 5.70e-02
H139Hfs13* PPM1K causes a mild variant of MSUD 5 7.40e-02 1.52e-01 0.6820 -5.62e-01 -0.386000 2.95e-02 1.35e-01
Maple Syrup Urine Disease 5 7.40e-02 1.52e-01 0.6820 -5.62e-01 -0.386000 2.95e-02 1.35e-01
POLB-Dependent Long Patch Base Excision Repair 8 4.35e-03 1.78e-02 0.6800 1.55e-01 0.663000 4.49e-01 1.17e-03
Abacavir ADME 5 7.67e-02 1.57e-01 0.6750 5.62e-01 0.374000 2.95e-02 1.48e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.75e-02 5.41e-02 0.6730 -6.73e-01 0.002020 9.18e-03 9.94e-01
Calcitonin-like ligand receptors 5 5.54e-02 1.26e-01 0.6660 6.21e-01 0.241000 1.61e-02 3.50e-01
SUMO is proteolytically processed 6 7.15e-03 2.63e-02 0.6530 -6.49e-01 0.069200 5.89e-03 7.69e-01
Acetylcholine binding and downstream events 5 7.02e-02 1.47e-01 0.6500 2.62e-01 0.595000 3.10e-01 2.13e-02
Postsynaptic nicotinic acetylcholine receptors 5 7.02e-02 1.47e-01 0.6500 2.62e-01 0.595000 3.10e-01 2.13e-02
Formation of the ureteric bud 5 1.00e-01 1.91e-01 0.6470 -3.92e-01 -0.515000 1.29e-01 4.63e-02
Phosphate bond hydrolysis by NUDT proteins 7 2.48e-02 6.94e-02 0.6450 -5.93e-01 -0.253000 6.58e-03 2.47e-01
Disorders of Developmental Biology 12 8.56e-04 4.88e-03 0.6390 1.59e-01 0.619000 3.41e-01 2.04e-04
Disorders of Nervous System Development 12 8.56e-04 4.88e-03 0.6390 1.59e-01 0.619000 3.41e-01 2.04e-04
Loss of function of MECP2 in Rett syndrome 12 8.56e-04 4.88e-03 0.6390 1.59e-01 0.619000 3.41e-01 2.04e-04
Pervasive developmental disorders 12 8.56e-04 4.88e-03 0.6390 1.59e-01 0.619000 3.41e-01 2.04e-04
Eicosanoids 8 1.80e-03 8.59e-03 0.6390 6.88e-02 -0.635000 7.36e-01 1.86e-03
NFE2L2 regulating MDR associated enzymes 8 2.88e-02 7.72e-02 0.6390 4.05e-01 0.495000 4.76e-02 1.54e-02
Unwinding of DNA 12 4.33e-03 1.78e-02 0.6380 3.67e-01 0.522000 2.77e-02 1.74e-03
PTK6 promotes HIF1A stabilization 6 7.26e-02 1.51e-01 0.6380 -4.71e-01 -0.429000 4.56e-02 6.86e-02
Type I hemidesmosome assembly 8 1.31e-02 4.27e-02 0.6230 1.77e-01 0.598000 3.86e-01 3.42e-03
PDH complex synthesizes acetyl-CoA from PYR 5 8.35e-02 1.68e-01 0.6230 -5.75e-01 -0.238000 2.59e-02 3.57e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 1.76e-03 8.43e-03 0.6140 -1.42e-01 0.598000 4.87e-01 3.42e-03
Activation of caspases through apoptosome-mediated cleavage 6 3.11e-02 8.24e-02 0.6090 -6.01e-01 -0.095800 1.08e-02 6.84e-01
Defective LFNG causes SCDO3 5 4.12e-02 1.02e-01 0.6050 1.81e-02 0.605000 9.44e-01 1.91e-02
Repression of WNT target genes 14 4.09e-03 1.70e-02 0.6000 3.72e-01 0.471000 1.59e-02 2.30e-03
Interleukin-9 signaling 8 2.31e-02 6.62e-02 0.5960 2.05e-01 0.560000 3.16e-01 6.08e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.97e-03 1.31e-02 0.5900 -5.88e-01 -0.046700 1.27e-03 7.98e-01
Estrogen-stimulated signaling through PRKCZ 6 4.60e-02 1.11e-01 0.5820 -5.71e-01 -0.110000 1.54e-02 6.39e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 3.86e-02 9.67e-02 0.5780 1.66e-01 0.554000 4.47e-01 1.12e-02
Small interfering RNA (siRNA) biogenesis 9 1.16e-02 3.88e-02 0.5770 -5.64e-01 -0.123000 3.38e-03 5.21e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 8.90e-10 2.81e-08 0.5770 -7.18e-02 0.572000 4.82e-01 2.08e-08
Formyl peptide receptors bind formyl peptides and many other ligands 7 6.82e-02 1.44e-01 0.5760 -4.95e-01 -0.294000 2.34e-02 1.78e-01
Formation of xylulose-5-phosphate 5 4.87e-02 1.15e-01 0.5700 -5.69e-01 0.031700 2.76e-02 9.02e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.85e-02 1.31e-01 0.5700 5.19e-01 0.235000 1.74e-02 2.82e-01
Activation of PUMA and translocation to mitochondria 9 2.17e-02 6.31e-02 0.5680 1.98e-01 0.533000 3.03e-01 5.66e-03
Activation of the AP-1 family of transcription factors 10 3.18e-02 8.31e-02 0.5670 -4.11e-01 -0.390000 2.43e-02 3.27e-02
Interleukin-2 signaling 11 1.03e-02 3.54e-02 0.5640 2.02e-01 0.527000 2.46e-01 2.49e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 4.65e-02 1.11e-01 0.5630 -4.14e-01 -0.382000 3.15e-02 4.71e-02
Beta-oxidation of pristanoyl-CoA 9 1.56e-02 4.95e-02 0.5620 -5.47e-01 -0.130000 4.50e-03 4.98e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 1.24e-03 6.34e-03 0.5610 2.70e-01 0.491000 4.72e-02 3.07e-04
Cytochrome c-mediated apoptotic response 13 2.54e-03 1.14e-02 0.5600 -5.45e-01 -0.128000 6.67e-04 4.25e-01
Formation of annular gap junctions 10 4.16e-04 2.70e-03 0.5600 -3.69e-01 0.421000 4.34e-02 2.12e-02
Biosynthesis of EPA-derived SPMs 6 3.21e-02 8.34e-02 0.5560 2.77e-02 -0.556000 9.07e-01 1.84e-02
ARMS-mediated activation 6 1.27e-01 2.29e-01 0.5560 -4.55e-01 -0.319000 5.35e-02 1.76e-01
Zygotic genome activation (ZGA) 5 1.79e-01 2.94e-01 0.5530 3.10e-01 0.459000 2.30e-01 7.58e-02
IFNG signaling activates MAPKs 8 7.00e-02 1.47e-01 0.5530 -4.30e-01 -0.347000 3.51e-02 8.94e-02
Apoptotic cleavage of cell adhesion proteins 8 5.54e-02 1.26e-01 0.5520 -4.85e-01 -0.263000 1.75e-02 1.97e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 3.38e-02 8.68e-02 0.5500 -1.54e-01 -0.528000 4.50e-01 9.74e-03
Norepinephrine Neurotransmitter Release Cycle 12 2.05e-02 6.08e-02 0.5500 3.79e-01 0.398000 2.31e-02 1.69e-02
Erythropoietin activates STAT5 6 4.72e-02 1.13e-01 0.5490 -5.47e-01 -0.035400 2.02e-02 8.81e-01
Apoptosis induced DNA fragmentation 10 2.21e-02 6.40e-02 0.5470 -5.04e-01 -0.212000 5.77e-03 2.45e-01
Synthesis of pyrophosphates in the cytosol 8 3.12e-03 1.36e-02 0.5450 -4.56e-01 0.298000 2.56e-02 1.44e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 2.00e-01 3.18e-01 0.5440 4.20e-01 0.346000 1.03e-01 1.81e-01
Processing and activation of SUMO 10 2.05e-03 9.59e-03 0.5440 -5.31e-01 0.121000 3.66e-03 5.07e-01
Lysosphingolipid and LPA receptors 11 3.11e-02 8.24e-02 0.5420 4.01e-01 0.364000 2.13e-02 3.65e-02
Processive synthesis on the C-strand of the telomere 19 1.33e-04 1.01e-03 0.5390 6.34e-02 0.535000 6.32e-01 5.33e-05
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 5 1.96e-01 3.14e-01 0.5390 -3.04e-01 -0.445000 2.39e-01 8.47e-02
NFE2L2 regulating ER-stress associated genes 5 1.69e-01 2.82e-01 0.5380 2.31e-01 0.485000 3.71e-01 6.02e-02
TGFBR3 regulates TGF-beta signaling 8 4.69e-03 1.88e-02 0.5360 -2.28e-01 0.485000 2.64e-01 1.74e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 4.60e-02 1.11e-01 0.5360 9.66e-02 0.527000 6.58e-01 1.57e-02
Glycosphingolipid transport 7 7.15e-03 2.63e-02 0.5330 -4.07e-01 0.344000 6.20e-02 1.15e-01
Passive transport by Aquaporins 6 9.92e-02 1.90e-01 0.5310 -1.65e-01 -0.505000 4.85e-01 3.21e-02
Defective binding of VWF variant to GPIb:IX:V 6 1.65e-02 5.15e-02 0.5310 4.50e-01 -0.282000 5.61e-02 2.31e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 6 1.65e-02 5.15e-02 0.5310 4.50e-01 -0.282000 5.61e-02 2.31e-01
Removal of the Flap Intermediate from the C-strand 17 1.63e-04 1.21e-03 0.5310 -1.33e-02 0.531000 9.24e-01 1.49e-04
Cohesin Loading onto Chromatin 10 1.11e-03 5.89e-03 0.5300 -4.50e-01 0.281000 1.38e-02 1.24e-01
Cation-coupled Chloride cotransporters 6 1.53e-01 2.62e-01 0.5280 4.36e-01 0.297000 6.42e-02 2.07e-01
NR1H2 and NR1H3-mediated signaling 38 3.65e-10 1.26e-08 0.5280 -1.03e-01 0.517000 2.70e-01 3.37e-08
ATF6 (ATF6-alpha) activates chaperones 12 1.41e-03 7.02e-03 0.5210 -5.14e-01 0.086900 2.06e-03 6.02e-01
Scavenging by Class F Receptors 5 8.81e-02 1.74e-01 0.5190 -6.58e-03 0.519000 9.80e-01 4.43e-02
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 3.85e-02 9.66e-02 0.5190 -2.74e-01 0.441000 2.89e-01 8.78e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 3.63e-03 1.55e-02 0.5150 -4.84e-01 -0.177000 8.09e-04 2.20e-01
Tandem pore domain potassium channels 5 4.03e-02 1.00e-01 0.5140 -2.80e-01 0.431000 2.77e-01 9.54e-02
Transport of nucleotide sugars 9 6.22e-02 1.36e-01 0.5130 -4.46e-01 -0.254000 2.05e-02 1.87e-01
Serotonin Neurotransmitter Release Cycle 13 2.39e-02 6.75e-02 0.5120 3.10e-01 0.407000 5.32e-02 1.10e-02
Miscellaneous substrates 8 1.35e-02 4.38e-02 0.5100 4.99e-01 -0.105000 1.45e-02 6.08e-01
Defects of platelet adhesion to exposed collagen 7 1.92e-02 5.82e-02 0.5100 4.88e-01 -0.146000 2.53e-02 5.03e-01
SARS-CoV-2 modulates autophagy 11 8.17e-04 4.74e-03 0.5090 -3.59e-01 0.361000 3.91e-02 3.82e-02
STAT3 nuclear events downstream of ALK signaling 11 1.71e-02 5.30e-02 0.5090 1.31e-01 0.492000 4.50e-01 4.74e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 1.82e-08 4.87e-07 0.5080 -4.65e-01 0.204000 1.04e-05 5.30e-02
Acetylcholine Neurotransmitter Release Cycle 10 5.31e-02 1.22e-01 0.5080 2.73e-01 0.428000 1.35e-01 1.91e-02
MET activates PI3K/AKT signaling 5 2.12e-01 3.31e-01 0.5080 -4.52e-01 -0.232000 8.03e-02 3.69e-01
Formation of apoptosome 11 1.69e-02 5.25e-02 0.5070 -4.91e-01 -0.126000 4.76e-03 4.70e-01
Regulation of the apoptosome activity 11 1.69e-02 5.25e-02 0.5070 -4.91e-01 -0.126000 4.76e-03 4.70e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 1.47e-02 4.69e-02 0.5050 -2.43e-01 -0.443000 1.15e-01 4.14e-03
Signal attenuation 9 8.17e-02 1.65e-01 0.5050 -3.12e-01 -0.397000 1.05e-01 3.92e-02
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 2.87e-02 7.70e-02 0.5040 -4.98e-01 0.077200 2.25e-02 7.24e-01
Negative feedback regulation of MAPK pathway 6 1.26e-01 2.29e-01 0.5040 -4.78e-01 -0.158000 4.25e-02 5.03e-01
HDL remodeling 6 1.49e-01 2.57e-01 0.5030 2.04e-01 0.460000 3.86e-01 5.12e-02
Advanced glycosylation endproduct receptor signaling 12 1.37e-02 4.42e-02 0.5030 -4.84e-01 -0.136000 3.67e-03 4.16e-01
Acyl chain remodelling of PI 10 5.00e-02 1.17e-01 0.5030 -2.40e-01 -0.441000 1.88e-01 1.56e-02
N-glycan trimming and elongation in the cis-Golgi 5 4.48e-02 1.08e-01 0.5010 -3.91e-01 0.313000 1.30e-01 2.25e-01
Noncanonical activation of NOTCH3 8 1.63e-02 5.13e-02 0.5010 -4.92e-01 0.096100 1.61e-02 6.38e-01
HDMs demethylate histones 22 2.13e-04 1.50e-03 0.5010 8.91e-02 0.493000 4.70e-01 6.30e-05
MAPK3 (ERK1) activation 10 5.82e-03 2.26e-02 0.5000 -4.90e-01 0.099800 7.32e-03 5.85e-01
Incretin synthesis, secretion, and inactivation 14 1.61e-02 5.07e-02 0.4990 -4.38e-01 -0.241000 4.59e-03 1.19e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.61e-02 5.07e-02 0.4990 -4.38e-01 -0.241000 4.59e-03 1.19e-01
TGFBR3 PTM regulation 10 4.40e-03 1.80e-02 0.4970 -4.74e-01 0.151000 9.46e-03 4.08e-01
Fatty acids 8 7.34e-03 2.67e-02 0.4970 3.75e-01 -0.326000 6.63e-02 1.10e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 8.14e-02 1.65e-01 0.4960 -4.87e-01 0.091400 5.91e-02 7.23e-01
Cellular response to mitochondrial stress 9 5.31e-02 1.22e-01 0.4940 -4.66e-01 -0.165000 1.55e-02 3.90e-01
Dermatan sulfate biosynthesis 6 1.69e-01 2.82e-01 0.4920 -4.43e-01 -0.215000 6.04e-02 3.62e-01
IRAK1 recruits IKK complex 14 2.36e-02 6.71e-02 0.4890 -4.03e-01 -0.278000 9.11e-03 7.15e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 2.36e-02 6.71e-02 0.4890 -4.03e-01 -0.278000 9.11e-03 7.15e-02
MASTL Facilitates Mitotic Progression 10 9.06e-03 3.19e-02 0.4880 -4.84e-01 0.066600 8.10e-03 7.15e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 5.25e-02 1.22e-01 0.4870 -4.77e-01 0.099900 4.30e-02 6.72e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 5.59e-02 1.26e-01 0.4870 1.49e-02 0.487000 9.46e-01 2.58e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 6.70e-03 2.50e-02 0.4850 -4.70e-01 0.121000 1.01e-02 5.07e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 6.27e-02 1.37e-01 0.4810 -4.18e-01 0.238000 1.06e-01 3.56e-01
SLC15A4:TASL-dependent IRF5 activation 6 4.14e-02 1.02e-01 0.4810 -4.42e-01 0.189000 6.06e-02 4.24e-01
Establishment of Sister Chromatid Cohesion 11 2.32e-03 1.06e-02 0.4800 -4.16e-01 0.239000 1.68e-02 1.70e-01
Gain-of-function MRAS complexes activate RAF signaling 8 7.57e-02 1.55e-01 0.4790 -4.61e-01 -0.133000 2.41e-02 5.16e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 7.57e-02 1.55e-01 0.4790 -4.61e-01 -0.133000 2.41e-02 5.16e-01
Signaling by MRAS-complex mutants 8 7.57e-02 1.55e-01 0.4790 -4.61e-01 -0.133000 2.41e-02 5.16e-01
APOBEC3G mediated resistance to HIV-1 infection 5 2.03e-01 3.22e-01 0.4790 1.39e-01 0.459000 5.90e-01 7.58e-02
Interleukin-23 signaling 7 3.75e-02 9.45e-02 0.4770 -9.67e-02 0.467000 6.58e-01 3.24e-02
HSF1-dependent transactivation 30 4.20e-04 2.71e-03 0.4770 2.54e-01 0.403000 1.61e-02 1.31e-04
Diseases of branched-chain amino acid catabolism 13 1.40e-02 4.51e-02 0.4760 -4.62e-01 -0.116000 3.93e-03 4.68e-01
Maturation of spike protein 9683686 5 6.54e-02 1.41e-01 0.4750 -2.52e-01 0.402000 3.29e-01 1.19e-01
HDR through MMEJ (alt-NHEJ) 12 1.64e-02 5.15e-02 0.4740 8.86e-02 0.466000 5.95e-01 5.18e-03
Regulation of TP53 Activity through Acetylation 29 5.89e-05 5.41e-04 0.4740 9.70e-02 0.464000 3.66e-01 1.54e-05
TRAF3-dependent IRF activation pathway 13 2.36e-02 6.71e-02 0.4720 1.75e-01 0.438000 2.74e-01 6.20e-03
ER Quality Control Compartment (ERQC) 21 3.78e-04 2.48e-03 0.4710 -4.70e-01 -0.029600 1.92e-04 8.14e-01
Synthesis of PI 5 3.03e-01 4.34e-01 0.4710 3.53e-01 0.312000 1.72e-01 2.27e-01
MET activates RAP1 and RAC1 10 5.76e-02 1.30e-01 0.4710 -4.36e-01 -0.177000 1.69e-02 3.33e-01
Mitotic Telophase/Cytokinesis 13 1.25e-03 6.36e-03 0.4680 -2.06e-01 0.420000 1.97e-01 8.68e-03
MAPK1 (ERK2) activation 9 1.84e-02 5.60e-02 0.4680 -4.60e-01 0.082800 1.68e-02 6.67e-01
Biosynthesis of E-series 18(S)-resolvins 5 1.45e-01 2.52e-01 0.4670 -4.29e-03 -0.467000 9.87e-01 7.06e-02
Signaling by ALK 24 1.31e-03 6.66e-03 0.4670 1.83e-01 0.429000 1.21e-01 2.72e-04
Histidine catabolism 7 1.02e-01 1.94e-01 0.4660 -9.31e-02 -0.456000 6.70e-01 3.65e-02
Keratan sulfate degradation 9 8.82e-02 1.75e-01 0.4640 -1.88e-01 -0.424000 3.29e-01 2.77e-02
Activation of NOXA and translocation to mitochondria 5 2.38e-01 3.63e-01 0.4630 1.53e-01 0.437000 5.54e-01 9.07e-02
Nef and signal transduction 8 5.53e-02 1.26e-01 0.4630 3.04e-02 0.462000 8.82e-01 2.37e-02
SMAC (DIABLO) binds to IAPs 7 8.26e-02 1.66e-01 0.4600 -4.59e-01 -0.032300 3.55e-02 8.82e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 8.26e-02 1.66e-01 0.4600 -4.59e-01 -0.032300 3.55e-02 8.82e-01
SMAC, XIAP-regulated apoptotic response 7 8.26e-02 1.66e-01 0.4600 -4.59e-01 -0.032300 3.55e-02 8.82e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 2.39e-01 3.64e-01 0.4600 -3.84e-01 -0.252000 1.03e-01 2.85e-01
PTK6 Regulates Cell Cycle 6 4.78e-02 1.14e-01 0.4590 -2.33e-01 0.396000 3.23e-01 9.33e-02
Processive synthesis on the lagging strand 15 1.20e-02 3.99e-02 0.4590 1.29e-01 0.441000 3.87e-01 3.13e-03
Gap junction degradation 11 3.21e-03 1.39e-02 0.4590 -2.90e-01 0.356000 9.56e-02 4.11e-02
Modulation by Mtb of host immune system 7 1.33e-01 2.37e-01 0.4580 -4.37e-01 -0.139000 4.55e-02 5.25e-01
RORA activates gene expression 18 9.03e-04 5.07e-03 0.4580 -2.47e-02 0.457000 8.56e-01 7.85e-04
Calnexin/calreticulin cycle 26 1.61e-05 1.76e-04 0.4580 -4.51e-01 0.080300 6.95e-05 4.79e-01
NRIF signals cell death from the nucleus 15 6.70e-03 2.50e-02 0.4570 -4.53e-01 -0.059700 2.38e-03 6.89e-01
Polo-like kinase mediated events 16 1.24e-02 4.07e-02 0.4540 1.54e-01 0.428000 2.86e-01 3.06e-03
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 6.03e-07 1.02e-05 0.4510 -4.45e-01 0.074300 5.23e-06 4.47e-01
FGFR2b ligand binding and activation 6 2.13e-01 3.33e-01 0.4510 4.14e-01 0.178000 7.88e-02 4.51e-01
G2/M DNA replication checkpoint 5 1.01e-01 1.93e-01 0.4500 -1.63e-01 0.419000 5.28e-01 1.04e-01
Synthesis of PG 8 2.70e-02 7.36e-02 0.4500 -1.52e-01 0.423000 4.56e-01 3.83e-02
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 3.31e-01 4.63e-01 0.4450 3.65e-01 0.254000 1.57e-01 3.25e-01
Cardiogenesis 14 3.72e-03 1.57e-02 0.4430 -8.08e-02 0.435000 6.01e-01 4.78e-03
NADE modulates death signalling 5 1.34e-01 2.38e-01 0.4430 -4.35e-01 0.084700 9.24e-02 7.43e-01
Propionyl-CoA catabolism 5 9.11e-02 1.79e-01 0.4420 -3.60e-01 0.256000 1.63e-01 3.22e-01
Bicarbonate transporters 9 6.75e-02 1.44e-01 0.4410 7.68e-02 0.434000 6.90e-01 2.40e-02
WNT5A-dependent internalization of FZD4 13 2.77e-03 1.23e-02 0.4410 -1.88e-01 0.399000 2.40e-01 1.28e-02
Alpha-oxidation of phytanate 6 2.54e-01 3.81e-01 0.4390 -3.85e-01 -0.211000 1.02e-01 3.71e-01
Replacement of protamines by nucleosomes in the male pronucleus 13 6.71e-02 1.44e-01 0.4390 -2.90e-01 -0.330000 7.00e-02 3.97e-02
Removal of the Flap Intermediate 14 1.67e-02 5.19e-02 0.4390 8.31e-02 0.431000 5.91e-01 5.23e-03
IRAK4 deficiency (TLR2/4) 15 1.91e-02 5.79e-02 0.4390 -4.18e-01 -0.133000 5.06e-03 3.72e-01
PD-1 signaling 28 1.47e-03 7.23e-03 0.4390 1.97e-01 0.392000 7.08e-02 3.34e-04
CD22 mediated BCR regulation 59 4.49e-07 8.08e-06 0.4380 1.64e-01 0.407000 2.98e-02 6.42e-08
Maturation of protein 3a 9683673 9 9.91e-02 1.90e-01 0.4370 1.42e-01 0.413000 4.61e-01 3.19e-02
Maturation of protein 3a 9694719 9 9.91e-02 1.90e-01 0.4370 1.42e-01 0.413000 4.61e-01 3.19e-02
ChREBP activates metabolic gene expression 7 1.21e-01 2.22e-01 0.4360 6.17e-02 0.432000 7.77e-01 4.78e-02
STAT5 Activation 7 3.99e-02 9.93e-02 0.4360 -3.71e-01 0.229000 8.90e-02 2.94e-01
p130Cas linkage to MAPK signaling for integrins 11 8.79e-02 1.74e-01 0.4330 -3.78e-01 -0.211000 2.98e-02 2.26e-01
Formation of the active cofactor, UDP-glucuronate 5 2.02e-01 3.20e-01 0.4310 -4.31e-01 -0.018200 9.53e-02 9.44e-01
Platelet sensitization by LDL 16 7.38e-03 2.68e-02 0.4310 -4.29e-01 -0.039400 2.96e-03 7.85e-01
CREB phosphorylation 7 7.60e-02 1.55e-01 0.4300 -4.25e-01 0.063500 5.13e-02 7.71e-01
Expression and translocation of olfactory receptors 52 8.00e-09 2.30e-07 0.4280 5.49e-02 -0.424000 4.93e-01 1.21e-07
Regulation of TP53 Activity through Association with Co-factors 13 1.91e-02 5.79e-02 0.4270 3.47e-02 0.426000 8.28e-01 7.82e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 5.53e-02 1.26e-01 0.4260 2.29e-01 0.360000 1.38e-01 1.99e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 8.50e-02 1.69e-01 0.4260 -3.56e-01 -0.234000 3.25e-02 1.61e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.01e-01 3.20e-01 0.4260 3.42e-01 0.254000 9.36e-02 2.14e-01
Neurotoxicity of clostridium toxins 8 2.11e-01 3.31e-01 0.4250 3.12e-01 0.289000 1.26e-01 1.57e-01
Suppression of apoptosis 7 1.25e-01 2.27e-01 0.4250 4.08e-02 0.423000 8.52e-01 5.26e-02
Pre-NOTCH Processing in Golgi 18 1.39e-03 6.98e-03 0.4230 -7.96e-02 0.415000 5.59e-01 2.29e-03
Retrograde neurotrophin signalling 12 4.90e-03 1.95e-02 0.4230 -2.69e-01 0.326000 1.06e-01 5.07e-02
SUMOylation of DNA replication proteins 46 6.79e-08 1.54e-06 0.4220 -7.19e-02 0.415000 3.99e-01 1.08e-06
TGFBR3 expression 20 4.23e-03 1.74e-02 0.4210 7.29e-02 0.415000 5.72e-01 1.31e-03
Uptake of dietary cobalamins into enterocytes 6 2.91e-01 4.19e-01 0.4210 2.12e-01 0.363000 3.68e-01 1.24e-01
Mitochondrial calcium ion transport 22 4.17e-03 1.73e-02 0.4190 -4.04e-01 -0.111000 1.04e-03 3.67e-01
Biosynthesis of Lipoxins (LX) 6 1.44e-01 2.51e-01 0.4180 1.93e-02 -0.417000 9.35e-01 7.67e-02
Coenzyme A biosynthesis 7 5.58e-02 1.26e-01 0.4180 -1.92e-01 0.371000 3.79e-01 8.91e-02
Regulation of TLR by endogenous ligand 15 2.57e-02 7.09e-02 0.4180 -4.01e-01 -0.117000 7.18e-03 4.32e-01
NFE2L2 regulating tumorigenic genes 11 1.29e-01 2.33e-01 0.4160 2.99e-01 0.289000 8.56e-02 9.65e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 2.60e-01 3.88e-01 0.4160 3.87e-01 0.154000 1.01e-01 5.13e-01
Vitamin B1 (thiamin) metabolism 5 2.65e-01 3.93e-01 0.4160 -4.09e-01 -0.072900 1.13e-01 7.78e-01
Nef Mediated CD4 Down-regulation 9 3.56e-02 9.06e-02 0.4150 -1.13e-01 0.399000 5.56e-01 3.82e-02
Regulation of HMOX1 expression and activity 5 1.40e-01 2.46e-01 0.4140 -1.63e-01 0.380000 5.27e-01 1.41e-01
Attenuation phase 23 9.81e-03 3.40e-02 0.4140 2.03e-01 0.360000 9.17e-02 2.76e-03
MyD88 deficiency (TLR2/4) 14 4.39e-02 1.07e-01 0.4110 -3.86e-01 -0.143000 1.25e-02 3.55e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 2.54e-01 3.81e-01 0.4110 -1.31e-01 -0.389000 5.78e-01 9.86e-02
CS/DS degradation 9 1.49e-01 2.57e-01 0.4100 -3.75e-01 -0.166000 5.12e-02 3.89e-01
DNA strand elongation 32 1.45e-03 7.14e-03 0.4100 1.82e-01 0.367000 7.51e-02 3.23e-04
Glycosphingolipid catabolism 31 1.83e-03 8.65e-03 0.4080 -3.66e-01 -0.180000 4.12e-04 8.24e-02
Other interleukin signaling 19 1.08e-02 3.68e-02 0.4080 1.03e-01 0.395000 4.38e-01 2.91e-03
G0 and Early G1 27 1.19e-03 6.12e-03 0.4050 7.64e-02 0.398000 4.92e-01 3.42e-04
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.81e-02 5.54e-02 0.4050 9.05e-03 0.405000 9.53e-01 8.77e-03
Activation of SMO 14 5.49e-02 1.26e-01 0.4030 1.57e-01 0.372000 3.09e-01 1.60e-02
p75NTR negatively regulates cell cycle via SC1 5 1.67e-01 2.80e-01 0.4030 -3.84e-01 0.124000 1.37e-01 6.31e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 3.95e-02 9.86e-02 0.4030 3.82e-01 -0.128000 4.70e-02 5.07e-01
RHOBTB3 ATPase cycle 10 1.96e-02 5.89e-02 0.4030 -2.15e-01 0.341000 2.40e-01 6.17e-02
Defective factor IX causes hemophilia B 6 8.93e-02 1.76e-01 0.4030 3.09e-01 -0.258000 1.89e-01 2.74e-01
Maturation of hRSV A proteins 13 2.52e-02 7.01e-02 0.4020 -4.02e-01 -0.008830 1.21e-02 9.56e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.21e-06 6.88e-05 0.4020 -1.83e-01 0.358000 7.33e-02 4.63e-04
Pentose phosphate pathway 13 2.47e-02 6.94e-02 0.4000 -4.00e-01 -0.001200 1.25e-02 9.94e-01
Condensation of Prometaphase Chromosomes 11 4.38e-02 1.06e-01 0.3990 -1.30e-03 0.399000 9.94e-01 2.20e-02
Frs2-mediated activation 11 7.02e-02 1.47e-01 0.3980 -3.91e-01 -0.073300 2.47e-02 6.74e-01
Prostanoid ligand receptors 8 2.32e-01 3.57e-01 0.3980 -3.40e-01 -0.206000 9.55e-02 3.13e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.77e-06 3.98e-05 0.3970 -1.41e-01 0.372000 1.44e-01 1.13e-04
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 4.29e-01 5.54e-01 0.3950 2.55e-01 0.302000 3.24e-01 2.42e-01
The activation of arylsulfatases 10 1.31e-01 2.35e-01 0.3940 -3.68e-01 -0.142000 4.39e-02 4.37e-01
Regulated proteolysis of p75NTR 11 4.95e-02 1.17e-01 0.3940 -3.94e-01 -0.006770 2.36e-02 9.69e-01
Hydrolysis of LPC 8 2.54e-01 3.81e-01 0.3940 -2.31e-01 -0.319000 2.58e-01 1.19e-01
Vitamin B2 (riboflavin) metabolism 6 3.28e-01 4.60e-01 0.3930 3.49e-01 0.181000 1.39e-01 4.43e-01
Interleukin-20 family signaling 17 2.13e-02 6.25e-02 0.3930 8.96e-02 0.383000 5.22e-01 6.32e-03
Sodium/Calcium exchangers 9 1.89e-01 3.06e-01 0.3920 -3.49e-01 -0.180000 7.02e-02 3.50e-01
Phospholipase C-mediated cascade; FGFR2 8 1.08e-01 2.03e-01 0.3920 3.92e-01 -0.006430 5.48e-02 9.75e-01
Telomere C-strand synthesis initiation 13 1.34e-02 4.35e-02 0.3920 -1.09e-01 0.376000 4.97e-01 1.87e-02
Acyl chain remodelling of PG 11 1.65e-01 2.78e-01 0.3900 -2.62e-01 -0.289000 1.32e-01 9.73e-02
Prolonged ERK activation events 13 4.88e-02 1.15e-01 0.3890 -3.83e-01 -0.069900 1.67e-02 6.63e-01
Regulation of PTEN localization 9 2.05e-01 3.23e-01 0.3890 -3.36e-01 -0.197000 8.10e-02 3.06e-01
Regulation of MECP2 expression and activity 29 3.35e-04 2.23e-03 0.3890 -1.22e-02 0.389000 9.09e-01 2.92e-04
PI-3K cascade:FGFR3 10 1.26e-01 2.28e-01 0.3880 -3.70e-01 -0.116000 4.25e-02 5.24e-01
Nuclear import of Rev protein 34 7.59e-06 9.56e-05 0.3880 -1.56e-01 0.355000 1.14e-01 3.41e-04
LTC4-CYSLTR mediated IL4 production 5 1.56e-01 2.65e-01 0.3860 -2.66e-01 0.280000 3.03e-01 2.78e-01
Vpr-mediated nuclear import of PICs 34 9.02e-06 1.12e-04 0.3850 -1.54e-01 0.354000 1.21e-01 3.60e-04
Carnitine shuttle 12 2.88e-02 7.72e-02 0.3850 -5.80e-02 0.381000 7.28e-01 2.24e-02
Classical antibody-mediated complement activation 70 2.38e-08 6.21e-07 0.3850 2.36e-02 0.384000 7.33e-01 2.68e-08
Translocation of ZAP-70 to Immunological synapse 24 1.34e-02 4.35e-02 0.3840 1.70e-01 0.344000 1.48e-01 3.48e-03
Synthesis of GDP-mannose 6 2.40e-01 3.66e-01 0.3840 4.70e-02 0.381000 8.42e-01 1.06e-01
Nef Mediated CD8 Down-regulation 7 1.89e-01 3.06e-01 0.3830 4.39e-02 0.381000 8.41e-01 8.10e-02
Defective HLCS causes multiple carboxylase deficiency 7 7.76e-02 1.58e-01 0.3830 -2.52e-01 0.289000 2.49e-01 1.85e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.81e-03 8.61e-03 0.3830 -3.33e-01 0.190000 1.46e-02 1.63e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 3.37e-02 8.66e-02 0.3830 -3.49e-01 0.157000 5.58e-02 3.91e-01
Golgi Associated Vesicle Biogenesis 55 6.45e-07 1.07e-05 0.3810 -3.81e-01 0.002640 1.04e-06 9.73e-01
Downregulation of ERBB4 signaling 8 2.28e-01 3.53e-01 0.3800 -3.51e-01 -0.146000 8.58e-02 4.75e-01
Synthesis of PIPs at the late endosome membrane 11 6.81e-02 1.44e-01 0.3800 -3.79e-01 -0.023700 2.95e-02 8.92e-01
Olfactory Signaling Pathway 57 1.64e-07 3.32e-06 0.3800 3.30e-02 -0.378000 6.67e-01 7.81e-07
SUMOylation of SUMOylation proteins 35 1.31e-05 1.49e-04 0.3770 -1.35e-01 0.353000 1.67e-01 3.06e-04
Regulation of signaling by NODAL 6 4.00e-01 5.27e-01 0.3770 -2.73e-01 -0.261000 2.47e-01 2.69e-01
Toxicity of botulinum toxin type D (botD) 5 4.48e-01 5.73e-01 0.3770 3.15e-01 0.206000 2.22e-01 4.26e-01
Toxicity of botulinum toxin type F (botF) 5 4.48e-01 5.73e-01 0.3770 3.15e-01 0.206000 2.22e-01 4.26e-01
Transcription of E2F targets under negative control by DREAM complex 19 3.26e-02 8.41e-02 0.3760 1.45e-01 0.347000 2.73e-01 8.89e-03
Defective RIPK1-mediated regulated necrosis 7 2.47e-01 3.73e-01 0.3760 1.01e-01 0.362000 6.45e-01 9.71e-02
Role of phospholipids in phagocytosis 89 2.06e-09 6.21e-08 0.3760 4.96e-02 0.372000 4.18e-01 1.24e-09
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 2.09e-02 6.17e-02 0.3760 1.81e-02 0.375000 9.00e-01 9.35e-03
Spry regulation of FGF signaling 16 2.39e-02 6.75e-02 0.3750 -3.74e-01 -0.033800 9.60e-03 8.15e-01
Scavenging of heme from plasma 71 1.43e-07 2.97e-06 0.3750 5.38e-02 0.371000 4.33e-01 6.26e-08
Rev-mediated nuclear export of HIV RNA 35 2.73e-05 2.80e-04 0.3740 -1.00e-01 0.360000 3.04e-01 2.26e-04
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 3.04e-01 4.35e-01 0.3740 2.02e-02 0.373000 9.38e-01 1.49e-01
Nucleotide biosynthesis 12 2.70e-02 7.36e-02 0.3730 -1.04e-01 0.358000 5.34e-01 3.15e-02
Interactions of Rev with host cellular proteins 37 9.73e-06 1.18e-04 0.3730 -1.29e-01 0.350000 1.73e-01 2.31e-04
Export of Viral Ribonucleoproteins from Nucleus 33 3.70e-05 3.58e-04 0.3730 -1.24e-01 0.352000 2.18e-01 4.73e-04
SUMOylation of immune response proteins 12 1.17e-01 2.17e-01 0.3720 1.40e-01 0.345000 4.02e-01 3.84e-02
Recycling of bile acids and salts 10 1.99e-01 3.17e-01 0.3720 1.87e-01 0.322000 3.05e-01 7.80e-02
G1/S-Specific Transcription 29 2.43e-03 1.10e-02 0.3720 7.56e-02 0.364000 4.81e-01 6.80e-04
RUNX3 regulates p14-ARF 10 2.17e-01 3.38e-01 0.3720 3.01e-01 0.218000 9.92e-02 2.33e-01
Viral Messenger RNA Synthesis 44 1.34e-06 2.02e-05 0.3720 -1.24e-01 0.350000 1.55e-01 5.82e-05
Transport and synthesis of PAPS 6 2.90e-01 4.18e-01 0.3710 -3.63e-01 -0.075700 1.23e-01 7.48e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.18e-04 9.33e-04 0.3710 -2.05e-01 0.309000 6.58e-02 5.38e-03
FCGR activation 77 3.22e-08 8.07e-07 0.3710 3.91e-02 0.369000 5.53e-01 2.19e-08
XBP1(S) activates chaperone genes 44 1.10e-06 1.70e-05 0.3710 -1.38e-01 0.344000 1.13e-01 7.84e-05
Synthesis of PIPs at the Golgi membrane 16 5.39e-03 2.12e-02 0.3700 -3.22e-01 0.181000 2.56e-02 2.10e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 6.97e-05 6.08e-04 0.3680 -1.17e-01 0.349000 2.53e-01 6.31e-04
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 6.97e-05 6.08e-04 0.3680 -1.17e-01 0.349000 2.53e-01 6.31e-04
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.60e-05 4.33e-04 0.3670 -1.51e-01 0.335000 1.40e-01 1.03e-03
ERBB2 Regulates Cell Motility 10 1.90e-01 3.06e-01 0.3670 -3.32e-01 -0.156000 6.91e-02 3.92e-01
TYSND1 cleaves peroxisomal proteins 7 2.36e-01 3.61e-01 0.3670 -3.61e-01 -0.065500 9.83e-02 7.64e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 6.87e-02 1.45e-01 0.3660 -2.61e-01 0.258000 2.02e-01 2.07e-01
Regulation of NPAS4 gene expression 11 3.25e-02 8.41e-02 0.3660 -1.55e-01 0.331000 3.72e-01 5.72e-02
Telomere C-strand (Lagging Strand) Synthesis 34 6.62e-04 3.95e-03 0.3660 4.42e-02 0.363000 6.56e-01 2.49e-04
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.66e-03 1.18e-02 0.3650 -3.53e-01 -0.092700 6.58e-04 3.72e-01
IRE1alpha activates chaperones 46 5.45e-07 9.55e-06 0.3650 -1.66e-01 0.325000 5.11e-02 1.38e-04
Signaling by Hippo 18 6.48e-02 1.40e-01 0.3650 -3.09e-01 -0.193000 2.31e-02 1.56e-01
Evasion by RSV of host interferon responses 20 5.61e-03 2.19e-02 0.3640 -4.60e-02 0.361000 7.22e-01 5.22e-03
Processing of SMDT1 15 6.05e-02 1.34e-01 0.3630 -3.50e-01 -0.097100 1.89e-02 5.15e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 1.40e-01 2.46e-01 0.3630 -3.55e-01 -0.077300 5.19e-02 6.72e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 6.06e-05 5.48e-04 0.3630 -3.31e-01 -0.149000 1.08e-05 4.72e-02
RUNX3 regulates WNT signaling 8 2.67e-01 3.96e-01 0.3630 3.31e-01 0.148000 1.05e-01 4.69e-01
Creation of C4 and C2 activators 72 7.53e-08 1.67e-06 0.3630 1.19e-02 0.363000 8.61e-01 1.03e-07
RHO GTPases Activate WASPs and WAVEs 35 6.04e-05 5.48e-04 0.3630 -3.52e-01 0.087000 3.13e-04 3.73e-01
Synthesis of PE 12 1.76e-01 2.91e-01 0.3620 -2.91e-01 -0.216000 8.10e-02 1.96e-01
Voltage gated Potassium channels 27 1.11e-03 5.89e-03 0.3620 3.60e-01 -0.037200 1.21e-03 7.38e-01
PINK1-PRKN Mediated Mitophagy 31 9.15e-03 3.21e-02 0.3620 -3.11e-01 -0.184000 2.72e-03 7.57e-02
PI3K events in ERBB4 signaling 6 3.82e-01 5.12e-01 0.3600 -3.26e-01 -0.153000 1.67e-01 5.15e-01
Suppression of phagosomal maturation 12 2.70e-02 7.36e-02 0.3600 -3.26e-01 0.151000 5.02e-02 3.64e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.58e-04 5.28e-03 0.3590 -3.92e-03 0.359000 9.70e-01 6.62e-04
Tat-mediated HIV elongation arrest and recovery 30 9.58e-04 5.28e-03 0.3590 -3.92e-03 0.359000 9.70e-01 6.62e-04
SUMOylation of ubiquitinylation proteins 39 9.43e-06 1.16e-04 0.3580 -1.47e-01 0.327000 1.12e-01 4.15e-04
Phase 3 - rapid repolarisation 6 3.59e-01 4.89e-01 0.3580 -3.37e-01 -0.120000 1.53e-01 6.09e-01
RUNX1 regulates expression of components of tight junctions 5 2.87e-01 4.16e-01 0.3580 4.25e-02 -0.355000 8.69e-01 1.69e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 3.05e-01 4.35e-01 0.3580 6.04e-02 0.353000 7.98e-01 1.35e-01
Androgen biosynthesis 5 4.59e-01 5.83e-01 0.3580 -1.59e-01 -0.320000 5.37e-01 2.15e-01
Ribosomal scanning and start codon recognition 58 9.91e-05 8.13e-04 0.3570 -3.25e-01 -0.148000 1.82e-05 5.14e-02
GABA synthesis, release, reuptake and degradation 11 1.80e-01 2.95e-01 0.3570 1.56e-01 0.321000 3.71e-01 6.53e-02
SOS-mediated signalling 7 3.45e-01 4.78e-01 0.3560 -1.66e-01 -0.315000 4.46e-01 1.49e-01
Phosphorylation of CD3 and TCR zeta chains 27 1.12e-02 3.79e-02 0.3560 1.25e-01 0.333000 2.60e-01 2.73e-03
Heme biosynthesis 13 1.68e-01 2.80e-01 0.3550 2.23e-01 0.277000 1.64e-01 8.41e-02
Translation initiation complex formation 58 1.03e-04 8.42e-04 0.3540 -3.25e-01 -0.141000 1.86e-05 6.29e-02
Activated point mutants of FGFR2 7 1.54e-01 2.64e-01 0.3540 3.43e-01 -0.089700 1.17e-01 6.81e-01
Role of ABL in ROBO-SLIT signaling 6 1.72e-01 2.86e-01 0.3540 -3.18e-01 0.155000 1.77e-01 5.10e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 1.19e-01 2.19e-01 0.3530 -3.42e-01 0.089900 9.41e-02 6.60e-01
Crosslinking of collagen fibrils 13 5.49e-02 1.26e-01 0.3530 3.25e-03 -0.353000 9.84e-01 2.77e-02
NPAS4 regulates expression of target genes 16 1.05e-01 1.99e-01 0.3520 -2.96e-01 -0.190000 4.04e-02 1.87e-01
Interactions of Vpr with host cellular proteins 37 2.30e-05 2.40e-04 0.3520 -1.51e-01 0.318000 1.11e-01 8.25e-04
NGF-stimulated transcription 32 1.20e-02 3.98e-02 0.3510 -2.91e-01 -0.197000 4.44e-03 5.35e-02
Lipophagy 7 1.94e-01 3.11e-01 0.3500 -3.48e-01 0.033100 1.11e-01 8.79e-01
HIV elongation arrest and recovery 32 8.28e-04 4.78e-03 0.3490 -9.41e-03 0.349000 9.27e-01 6.31e-04
Pausing and recovery of HIV elongation 32 8.28e-04 4.78e-03 0.3490 -9.41e-03 0.349000 9.27e-01 6.31e-04
Glucuronidation 8 2.63e-01 3.90e-01 0.3490 -3.33e-01 -0.106000 1.03e-01 6.05e-01
Nuclear events stimulated by ALK signaling in cancer 33 5.10e-03 2.01e-02 0.3490 1.23e-01 0.327000 2.23e-01 1.16e-03
Assembly Of The HIV Virion 15 2.42e-02 6.81e-02 0.3480 -6.60e-02 0.342000 6.58e-01 2.18e-02
Transport of the SLBP Dependant Mature mRNA 36 3.99e-05 3.84e-04 0.3480 -1.47e-01 0.315000 1.27e-01 1.06e-03
Regulation of CDH11 mRNA translation by microRNAs 8 1.14e-01 2.12e-01 0.3480 -1.21e-01 0.326000 5.53e-01 1.10e-01
Regulation of NPAS4 mRNA translation 8 1.14e-01 2.12e-01 0.3480 -1.21e-01 0.326000 5.53e-01 1.10e-01
Initial triggering of complement 80 1.07e-07 2.24e-06 0.3470 2.64e-02 0.346000 6.83e-01 9.01e-08
The role of Nef in HIV-1 replication and disease pathogenesis 28 4.00e-04 2.61e-03 0.3470 -1.47e-01 0.314000 1.78e-01 4.04e-03
p75NTR recruits signalling complexes 12 1.39e-01 2.45e-01 0.3470 -3.30e-01 -0.106000 4.78e-02 5.26e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 5.59e-03 2.19e-02 0.3460 1.23e-02 0.346000 9.15e-01 2.75e-03
Cargo concentration in the ER 31 5.92e-04 3.62e-03 0.3460 -3.42e-01 0.054200 9.83e-04 6.01e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 4.08e-01 5.34e-01 0.3450 1.41e-01 0.315000 5.49e-01 1.81e-01
Telomere Extension By Telomerase 23 2.58e-03 1.16e-02 0.3450 -1.00e-01 0.330000 4.05e-01 6.13e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 8.78e-02 1.74e-01 0.3450 -3.20e-01 0.128000 9.64e-02 5.05e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 3.91e-01 5.19e-01 0.3450 2.87e-01 0.191000 1.88e-01 3.82e-01
NS1 Mediated Effects on Host Pathways 40 8.67e-06 1.08e-04 0.3440 -2.06e-01 0.276000 2.41e-02 2.56e-03
Negative regulation of FGFR3 signaling 21 2.73e-02 7.41e-02 0.3440 -3.34e-01 -0.083000 8.09e-03 5.10e-01
Trafficking and processing of endosomal TLR 13 3.83e-02 9.63e-02 0.3440 -3.33e-01 0.085000 3.75e-02 5.96e-01
Resolution of Abasic Sites (AP sites) 38 1.04e-03 5.62e-03 0.3440 6.17e-02 0.338000 5.11e-01 3.09e-04
PECAM1 interactions 12 2.94e-02 7.84e-02 0.3440 -2.45e-01 0.241000 1.42e-01 1.48e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 3.17e-02 8.28e-02 0.3430 -3.41e-01 0.041800 2.23e-02 7.79e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 3.17e-02 8.28e-02 0.3430 -3.41e-01 0.041800 2.23e-02 7.79e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 3.17e-02 8.28e-02 0.3430 -3.41e-01 0.041800 2.23e-02 7.79e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 3.17e-02 8.28e-02 0.3430 -3.41e-01 0.041800 2.23e-02 7.79e-01
Signaling by CTNNB1 phospho-site mutants 15 3.17e-02 8.28e-02 0.3430 -3.41e-01 0.041800 2.23e-02 7.79e-01
Signaling by GSK3beta mutants 15 3.17e-02 8.28e-02 0.3430 -3.41e-01 0.041800 2.23e-02 7.79e-01
Transport of the SLBP independent Mature mRNA 35 6.20e-05 5.56e-04 0.3420 -1.59e-01 0.303000 1.04e-01 1.92e-03
Axonal growth inhibition (RHOA activation) 7 3.93e-01 5.20e-01 0.3420 -2.89e-01 -0.182000 1.85e-01 4.05e-01
p75NTR regulates axonogenesis 7 3.93e-01 5.20e-01 0.3420 -2.89e-01 -0.182000 1.85e-01 4.05e-01
FCGR3A-mediated IL10 synthesis 100 6.16e-09 1.80e-07 0.3410 3.66e-02 0.339000 5.27e-01 4.57e-09
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 7.04e-02 1.47e-01 0.3410 3.56e-02 0.339000 8.17e-01 2.82e-02
Extension of Telomeres 51 4.07e-05 3.90e-04 0.3390 1.29e-02 0.339000 8.74e-01 2.85e-05
Signaling by LTK in cancer 7 1.79e-01 2.94e-01 0.3380 -3.26e-01 0.089700 1.35e-01 6.81e-01
Apoptotic factor-mediated response 19 1.75e-02 5.39e-02 0.3380 -3.38e-01 0.019400 1.08e-02 8.84e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 1.82e-01 2.97e-01 0.3380 -2.19e-01 0.258000 3.53e-01 2.74e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 1.42e-01 2.48e-01 0.3380 -1.48e-01 -0.303000 3.36e-01 4.95e-02
Branched-chain amino acid catabolism 21 2.14e-02 6.27e-02 0.3370 -3.34e-01 -0.040500 7.97e-03 7.48e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 1.84e-01 3.00e-01 0.3370 -3.19e-01 -0.106000 6.66e-02 5.42e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 4.71e-04 2.99e-03 0.3360 -1.21e-01 0.314000 2.51e-01 2.94e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 6.48e-02 1.40e-01 0.3360 -3.35e-01 0.020100 3.64e-02 9.00e-01
Formation of the beta-catenin:TCF transactivating complex 44 2.94e-03 1.30e-02 0.3350 1.62e-01 0.293000 6.31e-02 7.58e-04
trans-Golgi Network Vesicle Budding 69 9.18e-07 1.45e-05 0.3350 -3.35e-01 0.004280 1.50e-06 9.51e-01
Reversible hydration of carbon dioxide 8 2.87e-01 4.16e-01 0.3350 3.21e-01 0.096300 1.16e-01 6.37e-01
Glycine degradation 7 2.11e-01 3.31e-01 0.3340 -5.13e-02 0.330000 8.14e-01 1.31e-01
Defective CFTR causes cystic fibrosis 47 1.07e-04 8.69e-04 0.3340 -3.33e-01 -0.007430 7.64e-05 9.30e-01
Integration of provirus 9 1.04e-01 1.96e-01 0.3330 -3.10e-01 0.123000 1.08e-01 5.24e-01
Synthesis of UDP-N-acetyl-glucosamine 8 1.48e-01 2.56e-01 0.3330 -3.21e-01 0.090100 1.16e-01 6.59e-01
Assembly of the ORC complex at the origin of replication 23 5.01e-02 1.18e-01 0.3330 -2.90e-01 -0.163000 1.60e-02 1.75e-01
Adenylate cyclase activating pathway 8 3.53e-01 4.84e-01 0.3330 1.63e-01 0.290000 4.26e-01 1.55e-01
SRP-dependent cotranslational protein targeting to membrane 110 4.10e-08 9.88e-07 0.3330 -3.20e-01 -0.092300 6.98e-09 9.43e-02
GAB1 signalosome 14 5.07e-02 1.18e-01 0.3330 -3.31e-01 0.033900 3.21e-02 8.26e-01
Activation of the pre-replicative complex 32 1.21e-03 6.20e-03 0.3320 -2.80e-02 0.331000 7.84e-01 1.18e-03
PI-3K cascade:FGFR1 13 1.87e-01 3.03e-01 0.3320 -2.88e-01 -0.166000 7.23e-02 3.00e-01
TBC/RABGAPs 45 3.19e-05 3.22e-04 0.3320 -7.32e-02 0.324000 3.96e-01 1.69e-04
Glycogen synthesis 11 1.39e-01 2.45e-01 0.3320 -3.30e-01 -0.036800 5.80e-02 8.33e-01
Signaling by NODAL 15 1.45e-01 2.52e-01 0.3320 -2.88e-01 -0.165000 5.37e-02 2.67e-01
ROBO receptors bind AKAP5 7 1.75e-01 2.90e-01 0.3310 -1.22e-01 0.308000 5.76e-01 1.58e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 3.66e-03 1.56e-02 0.3310 -1.83e-01 0.276000 1.47e-01 2.84e-02
VLDLR internalisation and degradation 15 1.82e-02 5.56e-02 0.3310 -1.86e-01 0.274000 2.13e-01 6.63e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 2.75e-02 7.43e-02 0.3310 -3.24e-01 0.064900 2.47e-02 6.53e-01
RSK activation 7 2.62e-01 3.90e-01 0.3310 -3.30e-01 -0.007020 1.30e-01 9.74e-01
Post-transcriptional silencing by small RNAs 7 1.50e-01 2.58e-01 0.3300 -2.16e-01 0.250000 3.22e-01 2.53e-01
N-Glycan antennae elongation 13 1.24e-01 2.27e-01 0.3300 7.35e-02 0.322000 6.46e-01 4.46e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 3.96e-02 9.88e-02 0.3300 -2.03e-01 0.260000 2.22e-01 1.19e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 6.27e-06 8.10e-05 0.3290 1.14e-01 0.309000 7.15e-02 9.96e-07
Membrane binding and targetting of GAG proteins 13 6.12e-02 1.35e-01 0.3280 -5.13e-02 0.324000 7.49e-01 4.33e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 6.12e-02 1.35e-01 0.3280 -5.13e-02 0.324000 7.49e-01 4.33e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.48e-02 6.94e-02 0.3280 -1.95e-01 0.263000 2.07e-01 8.81e-02
Deactivation of the beta-catenin transactivating complex 36 3.25e-03 1.41e-02 0.3270 6.96e-02 0.320000 4.70e-01 8.95e-04
Synthesis of PIPs at the early endosome membrane 16 2.48e-02 6.94e-02 0.3270 -3.14e-01 0.090600 2.95e-02 5.30e-01
Interleukin-6 signaling 11 6.17e-02 1.35e-01 0.3260 -2.87e-01 0.155000 9.90e-02 3.73e-01
SUMOylation of chromatin organization proteins 57 4.81e-07 8.51e-06 0.3260 -1.64e-01 0.282000 3.22e-02 2.28e-04
MET promotes cell motility 34 2.03e-02 6.06e-02 0.3260 -2.43e-01 -0.217000 1.40e-02 2.83e-02
Acyl chain remodelling of PE 20 9.78e-02 1.88e-01 0.3260 -2.57e-01 -0.201000 4.68e-02 1.19e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.54e-03 1.52e-02 0.3260 -3.26e-01 -0.003180 1.98e-03 9.76e-01
Nephron development 5 5.57e-01 6.61e-01 0.3250 1.92e-01 0.263000 4.58e-01 3.09e-01
OAS antiviral response 8 1.26e-01 2.28e-01 0.3250 -1.87e-01 0.266000 3.59e-01 1.93e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.18e-02 3.95e-02 0.3250 -9.85e-03 0.325000 9.35e-01 6.97e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 5.81e-02 1.30e-01 0.3250 -2.93e-01 -0.141000 1.75e-02 2.53e-01
Fructose catabolism 5 5.16e-01 6.31e-01 0.3240 -1.31e-01 -0.297000 6.11e-01 2.51e-01
HSF1 activation 26 1.17e-02 3.91e-02 0.3240 3.41e-02 0.322000 7.64e-01 4.47e-03
Inactivation of CDC42 and RAC1 7 4.54e-01 5.78e-01 0.3230 -2.45e-01 -0.211000 2.62e-01 3.33e-01
Cytosolic iron-sulfur cluster assembly 13 1.74e-01 2.88e-01 0.3230 1.21e-01 0.300000 4.50e-01 6.13e-02
Cell recruitment (pro-inflammatory response) 25 2.57e-02 7.09e-02 0.3230 -3.10e-01 -0.089800 7.21e-03 4.37e-01
Purinergic signaling in leishmaniasis infection 25 2.57e-02 7.09e-02 0.3230 -3.10e-01 -0.089800 7.21e-03 4.37e-01
FCERI mediated Ca+2 mobilization 93 1.81e-07 3.56e-06 0.3220 3.92e-02 0.320000 5.13e-01 9.50e-08
Diseases associated with surfactant metabolism 5 2.84e-01 4.14e-01 0.3220 2.73e-01 -0.172000 2.91e-01 5.05e-01
Activation of the phototransduction cascade 9 1.07e-01 2.00e-01 0.3220 2.79e-01 -0.161000 1.47e-01 4.04e-01
Signaling by TGFBR3 39 6.00e-05 5.48e-04 0.3220 -1.64e-01 0.278000 7.72e-02 2.69e-03
Molybdenum cofactor biosynthesis 6 2.19e-01 3.41e-01 0.3220 -1.79e-01 0.268000 4.49e-01 2.55e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.22e-01 2.23e-01 0.3220 -1.37e-02 0.322000 9.37e-01 6.45e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 110 6.49e-07 1.07e-05 0.3220 -2.94e-01 -0.131000 9.75e-08 1.78e-02
Role of LAT2/NTAL/LAB on calcium mobilization 78 1.06e-06 1.66e-05 0.3210 1.58e-02 0.321000 8.10e-01 9.50e-07
L13a-mediated translational silencing of Ceruloplasmin expression 109 6.70e-07 1.08e-05 0.3210 -2.95e-01 -0.126000 9.82e-08 2.34e-02
Mismatch Repair 15 6.21e-02 1.36e-01 0.3200 -5.05e-03 0.320000 9.73e-01 3.17e-02
Sperm Motility And Taxes 6 5.01e-01 6.20e-01 0.3200 2.65e-01 0.180000 2.61e-01 4.45e-01
Aryl hydrocarbon receptor signalling 6 2.80e-01 4.10e-01 0.3200 -3.14e-01 0.065300 1.84e-01 7.82e-01
Synthesis of 5-eicosatetraenoic acids 7 3.26e-01 4.59e-01 0.3200 -4.97e-02 -0.316000 8.20e-01 1.48e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 9.09e-02 1.79e-01 0.3190 -3.16e-01 -0.048500 3.44e-02 7.45e-01
Erythropoietin activates RAS 13 5.64e-02 1.27e-01 0.3180 -3.04e-01 0.094600 5.79e-02 5.55e-01
FGFR1 mutant receptor activation 25 6.80e-03 2.53e-02 0.3180 -3.15e-01 0.043800 6.41e-03 7.05e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 1.20e-01 2.21e-01 0.3180 -1.36e-01 0.287000 4.80e-01 1.36e-01
Infection with Mycobacterium tuberculosis 26 1.68e-03 8.10e-03 0.3180 -2.64e-01 0.176000 1.98e-02 1.19e-01
Formation of ATP by chemiosmotic coupling 20 2.00e-02 6.02e-02 0.3180 -3.16e-01 0.035500 1.45e-02 7.84e-01
Maturation of spike protein 9694548 36 1.22e-04 9.57e-04 0.3170 -2.22e-01 0.226000 2.12e-02 1.87e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 1.82e-03 8.63e-03 0.3170 -2.87e-01 -0.135000 4.00e-04 9.42e-02
Formation of axial mesoderm 6 4.90e-01 6.09e-01 0.3170 2.78e-01 0.152000 2.38e-01 5.19e-01
Regulation of signaling by CBL 22 4.93e-03 1.96e-02 0.3160 -1.68e-01 0.268000 1.73e-01 2.98e-02
MET activates PTK2 signaling 23 8.01e-02 1.62e-01 0.3160 -1.89e-01 -0.253000 1.16e-01 3.58e-02
MAP kinase activation 63 9.35e-05 7.77e-04 0.3160 -3.08e-01 -0.068700 2.33e-05 3.46e-01
Synthesis of very long-chain fatty acyl-CoAs 22 9.34e-02 1.82e-01 0.3150 -2.42e-01 -0.202000 4.95e-02 1.00e-01
Inhibition of Signaling by Overexpressed EGFR 5 5.16e-01 6.31e-01 0.3150 -2.97e-01 -0.104000 2.50e-01 6.86e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 5.16e-01 6.31e-01 0.3150 -2.97e-01 -0.104000 2.50e-01 6.86e-01
PERK regulates gene expression 31 2.81e-02 7.58e-02 0.3150 -2.72e-01 -0.158000 8.75e-03 1.28e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 8.54e-02 1.70e-01 0.3140 -3.00e-01 -0.091800 2.73e-02 5.00e-01
Thyroxine biosynthesis 5 3.00e-01 4.30e-01 0.3140 1.78e-01 -0.258000 4.90e-01 3.17e-01
Interleukin-15 signaling 14 1.21e-01 2.22e-01 0.3140 5.61e-02 0.309000 7.16e-01 4.55e-02
Signaling by activated point mutants of FGFR1 5 5.18e-01 6.32e-01 0.3130 -1.03e-01 -0.296000 6.91e-01 2.52e-01
RUNX1 regulates estrogen receptor mediated transcription 6 5.27e-01 6.40e-01 0.3130 2.44e-01 0.196000 3.01e-01 4.06e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 1.02e-01 1.94e-01 0.3130 -2.98e-01 -0.094900 3.34e-02 4.98e-01
Insulin receptor recycling 24 3.80e-02 9.58e-02 0.3130 -3.00e-01 -0.089300 1.10e-02 4.49e-01
ER-Phagosome pathway 75 5.31e-06 6.91e-05 0.3120 -3.11e-01 -0.024300 3.27e-06 7.16e-01
Nuclear Envelope Breakdown 53 3.78e-06 5.24e-05 0.3110 -1.71e-01 0.261000 3.16e-02 1.03e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.08e-01 2.02e-01 0.3110 -3.04e-01 0.068700 8.12e-02 6.93e-01
Cap-dependent Translation Initiation 117 6.70e-07 1.08e-05 0.3110 -2.85e-01 -0.124000 9.93e-08 2.07e-02
Eukaryotic Translation Initiation 117 6.70e-07 1.08e-05 0.3110 -2.85e-01 -0.124000 9.93e-08 2.07e-02
Synthesis of Dolichyl-phosphate 6 2.59e-01 3.87e-01 0.3110 -1.33e-01 0.281000 5.71e-01 2.34e-01
Synthesis of PA 31 2.18e-02 6.34e-02 0.3100 -2.87e-01 -0.118000 5.68e-03 2.55e-01
Fructose metabolism 7 4.37e-01 5.61e-01 0.3100 -2.80e-01 -0.134000 2.00e-01 5.40e-01
SUMOylation of RNA binding proteins 47 1.33e-05 1.50e-04 0.3100 -2.08e-01 0.230000 1.36e-02 6.43e-03
Endosomal/Vacuolar pathway 12 1.79e-01 2.94e-01 0.3100 -3.03e-01 -0.063600 6.90e-02 7.03e-01
Beta-catenin phosphorylation cascade 17 3.30e-02 8.49e-02 0.3090 -3.01e-01 0.070200 3.14e-02 6.16e-01
Biosynthesis of maresins 6 5.24e-01 6.37e-01 0.3090 2.57e-01 0.172000 2.75e-01 4.66e-01
Dissolution of Fibrin Clot 12 2.87e-01 4.16e-01 0.3080 -1.90e-01 -0.243000 2.55e-01 1.45e-01
Platelet degranulation 105 3.49e-06 4.87e-05 0.3080 -2.83e-01 -0.121000 5.42e-07 3.25e-02
Termination of O-glycan biosynthesis 16 1.85e-01 3.00e-01 0.3080 2.53e-01 0.176000 8.03e-02 2.24e-01
Citric acid cycle (TCA cycle) 34 2.42e-03 1.10e-02 0.3070 -3.07e-01 0.020400 1.96e-03 8.37e-01
Signaling by CSF3 (G-CSF) 29 4.14e-03 1.71e-02 0.3070 -3.03e-01 0.048700 4.67e-03 6.50e-01
ISG15 antiviral mechanism 72 4.70e-08 1.09e-06 0.3070 -2.19e-01 0.215000 1.28e-03 1.63e-03
RND2 GTPase cycle 36 2.32e-03 1.06e-02 0.3070 -1.87e-03 0.307000 9.85e-01 1.44e-03
Association of TriC/CCT with target proteins during biosynthesis 35 3.28e-04 2.20e-03 0.3070 -2.56e-01 0.170000 8.87e-03 8.22e-02
Organic anion transporters 7 4.60e-01 5.83e-01 0.3070 1.49e-01 0.268000 4.94e-01 2.19e-01
Interleukin receptor SHC signaling 23 5.97e-02 1.33e-01 0.3070 1.10e-01 0.286000 3.59e-01 1.76e-02
APC truncation mutants have impaired AXIN binding 14 6.82e-02 1.44e-01 0.3070 -3.01e-01 0.057000 5.10e-02 7.12e-01
AXIN missense mutants destabilize the destruction complex 14 6.82e-02 1.44e-01 0.3070 -3.01e-01 0.057000 5.10e-02 7.12e-01
Signaling by AMER1 mutants 14 6.82e-02 1.44e-01 0.3070 -3.01e-01 0.057000 5.10e-02 7.12e-01
Signaling by APC mutants 14 6.82e-02 1.44e-01 0.3070 -3.01e-01 0.057000 5.10e-02 7.12e-01
Signaling by AXIN mutants 14 6.82e-02 1.44e-01 0.3070 -3.01e-01 0.057000 5.10e-02 7.12e-01
Truncations of AMER1 destabilize the destruction complex 14 6.82e-02 1.44e-01 0.3070 -3.01e-01 0.057000 5.10e-02 7.12e-01
Response to elevated platelet cytosolic Ca2+ 109 2.37e-06 3.46e-05 0.3060 -2.82e-01 -0.118000 3.60e-07 3.39e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.39e-01 2.45e-01 0.3050 -3.04e-01 0.030800 8.11e-02 8.60e-01
CREB3 factors activate genes 6 4.16e-01 5.43e-01 0.3050 -3.02e-01 -0.046900 2.01e-01 8.42e-01
Creatine metabolism 6 4.49e-01 5.74e-01 0.3050 2.95e-01 0.078200 2.11e-01 7.40e-01
Glyoxylate metabolism and glycine degradation 13 5.18e-02 1.20e-01 0.3040 -1.84e-01 0.242000 2.51e-01 1.31e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.02e-01 1.94e-01 0.3040 -2.99e-01 -0.050900 3.82e-02 7.25e-01
Prolactin receptor signaling 11 1.40e-01 2.46e-01 0.3030 -3.01e-01 0.034200 8.34e-02 8.44e-01
Response of Mtb to phagocytosis 22 6.49e-03 2.45e-02 0.3030 -2.07e-01 0.222000 9.31e-02 7.16e-02
Metabolism of Angiotensinogen to Angiotensins 12 1.83e-01 2.98e-01 0.3030 -5.21e-02 -0.299000 7.55e-01 7.32e-02
EPH-ephrin mediated repulsion of cells 43 1.38e-04 1.04e-03 0.3030 -1.08e-01 0.283000 2.22e-01 1.30e-03
Respiratory syncytial virus (RSV) attachment and entry 19 1.61e-02 5.07e-02 0.3030 -1.42e-01 0.267000 2.83e-01 4.35e-02
Depolymerization of the Nuclear Lamina 15 5.32e-02 1.23e-01 0.3020 -2.92e-01 0.078600 5.02e-02 5.98e-01
Eicosanoid ligand-binding receptors 13 1.76e-01 2.90e-01 0.3020 -2.94e-01 -0.069400 6.62e-02 6.65e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.28e-04 9.93e-04 0.3020 -1.18e-01 0.277000 1.79e-01 1.65e-03
Activation of the TFAP2 (AP-2) family of transcription factors 7 5.04e-01 6.22e-01 0.3010 2.02e-01 0.224000 3.55e-01 3.05e-01
Nuclear Events (kinase and transcription factor activation) 54 1.55e-03 7.55e-03 0.3010 -2.83e-01 -0.104000 3.24e-04 1.85e-01
Regulation of ornithine decarboxylase (ODC) 38 4.64e-03 1.87e-02 0.3010 -2.97e-01 -0.047600 1.51e-03 6.11e-01
Calcineurin activates NFAT 9 1.54e-01 2.64e-01 0.3010 -2.78e-01 0.117000 1.49e-01 5.44e-01
LGI-ADAM interactions 9 3.72e-01 5.03e-01 0.3010 1.35e-01 0.269000 4.83e-01 1.62e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.17e-01 2.16e-01 0.3010 -4.18e-02 0.298000 8.02e-01 7.39e-02
Kinesins 51 5.67e-03 2.21e-02 0.3010 2.49e-01 0.168000 2.08e-03 3.76e-02
FCGR3A-mediated phagocytosis 122 5.06e-11 2.12e-09 0.3000 -8.35e-02 0.289000 1.11e-01 3.63e-08
Leishmania phagocytosis 122 5.06e-11 2.12e-09 0.3000 -8.35e-02 0.289000 1.11e-01 3.63e-08
Parasite infection 122 5.06e-11 2.12e-09 0.3000 -8.35e-02 0.289000 1.11e-01 3.63e-08
Regulation of IFNA/IFNB signaling 12 1.43e-01 2.49e-01 0.3000 -3.84e-03 0.300000 9.82e-01 7.17e-02
Hedgehog ligand biogenesis 47 7.99e-04 4.67e-03 0.3000 -3.00e-01 -0.020400 3.80e-04 8.09e-01
Fcgamma receptor (FCGR) dependent phagocytosis 148 7.39e-13 4.07e-11 0.3000 -7.10e-02 0.291000 1.36e-01 9.25e-10
Apoptotic execution phase 46 1.81e-03 8.61e-03 0.2990 -2.95e-01 -0.053100 5.45e-04 5.33e-01
Regulation of actin dynamics for phagocytic cup formation 124 1.45e-10 5.58e-09 0.2990 -5.91e-02 0.293000 2.56e-01 1.79e-08
Heme signaling 45 8.09e-05 6.90e-04 0.2980 -1.35e-01 0.266000 1.18e-01 1.99e-03
Lysosome Vesicle Biogenesis 32 1.52e-03 7.44e-03 0.2980 -2.76e-01 0.113000 6.92e-03 2.67e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 6.02e-02 1.34e-01 0.2980 -2.95e-01 0.041100 4.08e-02 7.76e-01
Folding of actin by CCT/TriC 10 1.30e-01 2.34e-01 0.2980 -2.73e-01 0.118000 1.34e-01 5.19e-01
2-LTR circle formation 7 2.19e-01 3.41e-01 0.2980 -2.43e-01 0.172000 2.65e-01 4.32e-01
SUMOylation of DNA damage response and repair proteins 77 1.73e-07 3.43e-06 0.2970 -1.17e-01 0.273000 7.69e-02 3.34e-05
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 3.53e-02 9.01e-02 0.2970 -2.63e-01 0.138000 6.87e-02 3.38e-01
SUMOylation 167 6.85e-15 4.71e-13 0.2970 -9.83e-02 0.280000 2.83e-02 4.02e-10
Signaling by BRAF and RAF1 fusions 60 5.27e-04 3.29e-03 0.2970 -2.87e-01 -0.076500 1.20e-04 3.05e-01
SUMO E3 ligases SUMOylate target proteins 161 6.40e-14 4.11e-12 0.2970 -8.17e-02 0.285000 7.35e-02 4.28e-10
SIRT1 negatively regulates rRNA expression 22 1.21e-01 2.22e-01 0.2960 -2.34e-01 -0.181000 5.70e-02 1.42e-01
Attachment and Entry 9694614 15 9.35e-02 1.82e-01 0.2950 -6.35e-03 0.295000 9.66e-01 4.78e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.97e-04 1.41e-03 0.2950 -1.28e-01 0.266000 1.52e-01 2.84e-03
CTLA4 inhibitory signaling 21 2.30e-02 6.61e-02 0.2950 -2.89e-01 0.059700 2.19e-02 6.36e-01
Synthesis of PC 23 5.77e-02 1.30e-01 0.2950 -2.85e-01 -0.075800 1.81e-02 5.29e-01
Metabolism of polyamines 46 1.76e-03 8.43e-03 0.2940 -2.92e-01 -0.039800 6.17e-04 6.40e-01
Keratan sulfate biosynthesis 20 1.10e-01 2.05e-01 0.2940 1.15e-01 0.271000 3.75e-01 3.57e-02
Defects in biotin (Btn) metabolism 8 1.81e-01 2.96e-01 0.2940 -2.34e-01 0.178000 2.52e-01 3.82e-01
IKK complex recruitment mediated by RIP1 23 5.10e-02 1.19e-01 0.2940 -2.88e-01 -0.060600 1.69e-02 6.15e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.09e-05 1.28e-04 0.2940 -1.51e-01 0.252000 5.25e-02 1.21e-03
Protein lipoylation 10 2.73e-01 4.02e-01 0.2940 -2.88e-01 -0.058800 1.15e-01 7.47e-01
Prevention of phagosomal-lysosomal fusion 9 1.62e-01 2.75e-01 0.2940 -2.64e-01 0.128000 1.70e-01 5.05e-01
Surfactant metabolism 20 1.14e-01 2.12e-01 0.2940 -1.19e-01 -0.269000 3.58e-01 3.75e-02
Loss of Function of TGFBR1 in Cancer 7 3.25e-01 4.57e-01 0.2940 -2.93e-01 0.016800 1.79e-01 9.39e-01
TRAF6 mediated IRF7 activation 15 1.42e-01 2.48e-01 0.2940 5.70e-02 0.288000 7.03e-01 5.35e-02
RSV-host interactions 78 7.17e-07 1.14e-05 0.2930 -7.09e-02 0.285000 2.79e-01 1.39e-05
Regulation of CDH11 function 9 4.36e-01 5.61e-01 0.2930 2.08e-01 0.207000 2.80e-01 2.83e-01
Interleukin-35 Signalling 12 9.74e-02 1.88e-01 0.2930 -2.73e-01 0.107000 1.02e-01 5.22e-01
Hh mutants abrogate ligand secretion 43 1.15e-03 6.04e-03 0.2930 -2.92e-01 0.012100 9.06e-04 8.91e-01
Reduction of cytosolic Ca++ levels 9 1.48e-01 2.55e-01 0.2930 -1.92e-01 0.221000 3.19e-01 2.51e-01
Loss of Function of SMAD2/3 in Cancer 7 2.55e-01 3.83e-01 0.2920 -2.70e-01 0.112000 2.16e-01 6.07e-01
Diseases of Mismatch Repair (MMR) 5 3.66e-01 4.97e-01 0.2920 -2.60e-01 0.133000 3.14e-01 6.07e-01
Potential therapeutics for SARS 150 4.66e-10 1.55e-08 0.2920 1.83e-02 0.291000 6.99e-01 7.46e-10
RMTs methylate histone arginines 35 6.08e-03 2.33e-02 0.2920 1.33e-02 0.291000 8.92e-01 2.87e-03
Signaling by Erythropoietin 24 7.21e-03 2.64e-02 0.2910 -1.55e-01 0.247000 1.90e-01 3.61e-02
Tie2 Signaling 16 4.62e-02 1.11e-01 0.2910 -2.71e-01 0.106000 6.01e-02 4.63e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.39e-01 3.64e-01 0.2900 -2.80e-01 -0.078500 9.34e-02 6.38e-01
alpha-linolenic acid (ALA) metabolism 12 2.39e-01 3.64e-01 0.2900 -2.80e-01 -0.078500 9.34e-02 6.38e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 1.70e-01 2.83e-01 0.2890 -2.79e-01 -0.078900 6.18e-02 5.97e-01
Biotin transport and metabolism 11 1.25e-01 2.27e-01 0.2890 -1.04e-01 0.270000 5.50e-01 1.21e-01
Interleukin-2 family signaling 38 8.99e-03 3.18e-02 0.2890 6.24e-02 0.283000 5.05e-01 2.58e-03
Hh mutants are degraded by ERAD 42 1.43e-03 7.08e-03 0.2890 -2.89e-01 0.017600 1.21e-03 8.44e-01
Class I peroxisomal membrane protein import 20 2.11e-02 6.22e-02 0.2890 -2.63e-01 0.119000 4.19e-02 3.56e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 5.62e-07 9.68e-06 0.2880 -1.50e-01 0.246000 2.73e-02 3.12e-04
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 3.67e-02 9.30e-02 0.2880 1.96e-01 -0.211000 1.74e-01 1.44e-01
IkBA variant leads to EDA-ID 7 4.60e-01 5.83e-01 0.2880 9.49e-02 0.272000 6.64e-01 2.13e-01
Interleukin-17 signaling 68 1.40e-04 1.05e-03 0.2880 -2.85e-01 -0.040800 4.92e-05 5.60e-01
CD163 mediating an anti-inflammatory response 9 4.12e-01 5.38e-01 0.2870 -2.54e-01 -0.135000 1.87e-01 4.84e-01
Retrograde transport at the Trans-Golgi-Network 49 1.07e-04 8.69e-04 0.2870 -2.67e-01 0.105000 1.21e-03 2.03e-01
Signaling by Activin 13 1.27e-01 2.29e-01 0.2870 -2.86e-01 0.029700 7.47e-02 8.53e-01
Negative regulation of FGFR4 signaling 22 6.07e-02 1.35e-01 0.2860 -2.83e-01 -0.046800 2.18e-02 7.04e-01
Formation of Incision Complex in GG-NER 43 5.05e-03 2.00e-02 0.2860 -2.80e-01 -0.057700 1.46e-03 5.13e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 2.95e-10 1.07e-08 0.2860 -2.13e-01 0.191000 1.31e-04 5.89e-04
Metabolism of porphyrins 22 1.39e-01 2.45e-01 0.2860 1.72e-01 0.228000 1.61e-01 6.40e-02
Negative regulation of FGFR1 signaling 25 8.29e-02 1.67e-01 0.2860 -2.57e-01 -0.126000 2.64e-02 2.76e-01
Defective GALNT3 causes HFTC 9 2.92e-01 4.20e-01 0.2860 2.85e-01 0.020600 1.39e-01 9.15e-01
RIP-mediated NFkB activation via ZBP1 17 9.66e-02 1.87e-01 0.2850 1.88e-02 0.285000 8.93e-01 4.21e-02
Signal regulatory protein family interactions 13 9.81e-02 1.88e-01 0.2850 -2.71e-01 0.087400 9.02e-02 5.85e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 6.45e-01 7.34e-01 0.2850 1.87e-01 0.215000 4.69e-01 4.05e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 4.91e-04 3.10e-03 0.2850 -7.35e-02 0.275000 3.99e-01 1.58e-03
Interleukin-27 signaling 11 1.41e-01 2.48e-01 0.2840 -2.69e-01 0.089300 1.22e-01 6.08e-01
Formation of a pool of free 40S subunits 99 3.65e-05 3.58e-04 0.2840 -2.63e-01 -0.107000 6.17e-06 6.55e-02
RAF activation 33 1.76e-02 5.41e-02 0.2840 -2.79e-01 -0.053000 5.57e-03 5.98e-01
Alternative complement activation 5 4.98e-01 6.17e-01 0.2840 1.00e-02 0.284000 9.69e-01 2.72e-01
Generation of second messenger molecules 38 2.57e-02 7.09e-02 0.2830 1.31e-01 0.251000 1.63e-01 7.30e-03
Lagging Strand Synthesis 20 9.99e-02 1.91e-01 0.2830 7.04e-02 0.274000 5.86e-01 3.39e-02
Free fatty acids regulate insulin secretion 10 2.90e-01 4.19e-01 0.2830 -2.79e-01 -0.047400 1.27e-01 7.95e-01
Neurofascin interactions 5 3.85e-01 5.15e-01 0.2830 1.37e-01 -0.247000 5.95e-01 3.38e-01
CD28 dependent Vav1 pathway 12 1.15e-01 2.12e-01 0.2820 -2.63e-01 0.103000 1.14e-01 5.38e-01
Metabolic disorders of biological oxidation enzymes 23 1.36e-01 2.42e-01 0.2820 -1.77e-01 -0.220000 1.41e-01 6.83e-02
The NLRP3 inflammasome 16 7.03e-02 1.47e-01 0.2820 -2.75e-01 0.061600 5.65e-02 6.70e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 4.28e-02 1.04e-01 0.2820 -2.05e-02 0.281000 8.71e-01 2.56e-02
EPHB-mediated forward signaling 40 9.62e-04 5.28e-03 0.2810 -2.68e-01 0.086000 3.36e-03 3.47e-01
GRB2 events in EGFR signaling 10 3.58e-01 4.89e-01 0.2810 -2.62e-01 -0.104000 1.52e-01 5.70e-01
Activation of BAD and translocation to mitochondria 15 2.76e-01 4.06e-01 0.2810 -2.19e-01 -0.175000 1.42e-01 2.39e-01
AMPK inhibits chREBP transcriptional activation activity 6 5.61e-01 6.63e-01 0.2810 -2.52e-01 -0.123000 2.84e-01 6.03e-01
Activation of RAC1 11 3.73e-01 5.04e-01 0.2800 -2.37e-01 -0.150000 1.74e-01 3.88e-01
Activation of gene expression by SREBF (SREBP) 42 9.19e-04 5.10e-03 0.2800 -6.95e-02 0.271000 4.36e-01 2.33e-03
Translation of Structural Proteins 9694635 56 1.83e-05 1.97e-04 0.2800 -2.10e-01 0.186000 6.65e-03 1.62e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.46e-01 2.53e-01 0.2790 4.73e-03 0.279000 9.76e-01 7.02e-02
Regulation of BACH1 activity 11 3.40e-01 4.72e-01 0.2790 -2.56e-01 -0.112000 1.42e-01 5.19e-01
RHOV GTPase cycle 36 1.55e-03 7.54e-03 0.2790 -1.16e-01 0.253000 2.28e-01 8.55e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 1.23e-01 2.25e-01 0.2780 -1.64e-01 0.224000 3.45e-01 1.97e-01
Defective EXT2 causes exostoses 2 11 1.23e-01 2.25e-01 0.2780 -1.64e-01 0.224000 3.45e-01 1.97e-01
GLI3 is processed to GLI3R by the proteasome 46 9.06e-04 5.07e-03 0.2780 -2.76e-01 0.037500 1.22e-03 6.60e-01
mRNA Capping 29 5.39e-03 2.12e-02 0.2780 -2.51e-01 0.120000 1.93e-02 2.65e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 3.15e-06 4.46e-05 0.2780 2.16e-03 0.278000 9.71e-01 3.64e-06
RNA Pol II CTD phosphorylation and interaction with CE 27 5.98e-03 2.31e-02 0.2780 -2.22e-01 0.166000 4.55e-02 1.35e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 5.98e-03 2.31e-02 0.2780 -2.22e-01 0.166000 4.55e-02 1.35e-01
Initiation of Nuclear Envelope (NE) Reformation 19 3.12e-02 8.26e-02 0.2770 -2.43e-01 0.133000 6.69e-02 3.15e-01
Purine ribonucleoside monophosphate biosynthesis 9 1.80e-01 2.95e-01 0.2770 -1.82e-01 0.209000 3.44e-01 2.79e-01
Signaling by KIT in disease 20 2.46e-02 6.91e-02 0.2770 -2.35e-01 0.146000 6.89e-02 2.57e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.46e-02 6.91e-02 0.2770 -2.35e-01 0.146000 6.89e-02 2.57e-01
activated TAK1 mediates p38 MAPK activation 23 9.69e-02 1.87e-01 0.2770 -2.60e-01 -0.094600 3.08e-02 4.32e-01
NRAGE signals death through JNK 52 3.73e-03 1.57e-02 0.2760 7.52e-02 0.266000 3.48e-01 9.07e-04
HIV Transcription Initiation 45 1.19e-03 6.12e-03 0.2760 -2.74e-01 0.036200 1.49e-03 6.74e-01
RNA Polymerase II HIV Promoter Escape 45 1.19e-03 6.12e-03 0.2760 -2.74e-01 0.036200 1.49e-03 6.74e-01
RNA Polymerase II Promoter Escape 45 1.19e-03 6.12e-03 0.2760 -2.74e-01 0.036200 1.49e-03 6.74e-01
RNA Polymerase II Transcription Initiation 45 1.19e-03 6.12e-03 0.2760 -2.74e-01 0.036200 1.49e-03 6.74e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.19e-03 6.12e-03 0.2760 -2.74e-01 0.036200 1.49e-03 6.74e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.19e-03 6.12e-03 0.2760 -2.74e-01 0.036200 1.49e-03 6.74e-01
Malate-aspartate shuttle 8 3.23e-01 4.55e-01 0.2760 -1.44e-02 0.275000 9.44e-01 1.77e-01
Early Phase of HIV Life Cycle 14 7.09e-02 1.48e-01 0.2760 -1.90e-01 0.199000 2.18e-01 1.96e-01
Tryptophan catabolism 12 1.99e-01 3.17e-01 0.2750 -2.75e-01 -0.001640 9.86e-02 9.92e-01
Common Pathway of Fibrin Clot Formation 13 3.48e-01 4.80e-01 0.2750 -1.94e-01 -0.195000 2.26e-01 2.23e-01
Deadenylation of mRNA 22 3.19e-02 8.31e-02 0.2750 -2.69e-01 0.057700 2.91e-02 6.39e-01
Plasma lipoprotein clearance 32 7.69e-03 2.78e-02 0.2750 -4.62e-02 0.271000 6.51e-01 8.02e-03
Transcriptional regulation of testis differentiation 5 4.79e-01 5.98e-01 0.2750 2.73e-01 -0.033200 2.91e-01 8.98e-01
Respiratory Syncytial Virus Infection Pathway 99 3.44e-08 8.50e-07 0.2750 -1.12e-01 0.251000 5.44e-02 1.62e-05
Methylation 13 2.54e-01 3.81e-01 0.2740 -2.63e-01 -0.075100 1.00e-01 6.39e-01
Attachment of GPI anchor to uPAR 7 2.79e-01 4.09e-01 0.2740 -2.30e-01 0.148000 2.92e-01 4.96e-01
PCNA-Dependent Long Patch Base Excision Repair 21 5.07e-02 1.18e-01 0.2740 -2.18e-02 0.273000 8.63e-01 3.04e-02
Regulation of Apoptosis 40 9.24e-03 3.24e-02 0.2740 -2.70e-01 -0.042300 3.08e-03 6.43e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 6.63e-03 2.49e-02 0.2740 7.68e-02 0.262000 3.57e-01 1.65e-03
Host Interactions of HIV factors 118 3.16e-10 1.13e-08 0.2740 -1.83e-01 0.203000 5.84e-04 1.39e-04
Degradation of GLI2 by the proteasome 45 1.35e-03 6.80e-03 0.2730 -2.71e-01 0.037000 1.69e-03 6.68e-01
Cytoprotection by HMOX1 53 1.58e-04 1.17e-03 0.2730 -9.08e-02 0.257000 2.53e-01 1.21e-03
COPII-mediated vesicle transport 67 7.20e-06 9.19e-05 0.2720 -2.37e-01 0.134000 7.87e-04 5.84e-02
SHC1 events in ERBB4 signaling 10 3.78e-01 5.09e-01 0.2720 -2.55e-01 -0.096200 1.63e-01 5.98e-01
Interferon alpha/beta signaling 64 6.41e-05 5.72e-04 0.2720 -5.04e-02 0.267000 4.85e-01 2.14e-04
G beta:gamma signalling through CDC42 17 1.40e-01 2.46e-01 0.2720 -2.69e-01 -0.042900 5.50e-02 7.59e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 1.17e-02 3.93e-02 0.2720 -2.70e-01 -0.029900 4.45e-03 7.53e-01
Translation of Structural Proteins 9683701 29 8.75e-03 3.10e-02 0.2720 -8.72e-02 0.257000 4.17e-01 1.64e-02
Regulation of Complement cascade 97 1.03e-05 1.22e-04 0.2720 3.29e-02 0.270000 5.76e-01 4.46e-06
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 2.83e-02 7.63e-02 0.2710 -2.70e-01 -0.020900 1.17e-02 8.46e-01
ABC transporter disorders 60 4.66e-04 2.98e-03 0.2710 -2.71e-01 -0.007420 2.82e-04 9.21e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 1.19e-01 2.19e-01 0.2710 -2.54e-01 0.092500 1.12e-01 5.63e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.98e-04 1.42e-03 0.2710 -2.37e-01 -0.131000 4.69e-05 2.40e-02
Vpu mediated degradation of CD4 39 6.36e-03 2.42e-02 0.2710 -2.71e-01 -0.001520 3.46e-03 9.87e-01
RAB geranylgeranylation 63 2.83e-04 1.93e-03 0.2700 -2.70e-01 -0.000753 2.06e-04 9.92e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 5.86e-01 6.85e-01 0.2700 1.17e-01 0.243000 6.18e-01 3.04e-01
Chromatin modifying enzymes 214 1.41e-13 7.97e-12 0.2690 -2.63e-02 0.268000 5.08e-01 1.33e-11
Chromatin organization 214 1.41e-13 7.97e-12 0.2690 -2.63e-02 0.268000 5.08e-01 1.33e-11
Signaling by high-kinase activity BRAF mutants 33 2.90e-02 7.76e-02 0.2690 -2.63e-01 -0.058800 8.96e-03 5.59e-01
RNA Polymerase I Promoter Opening 17 2.67e-01 3.96e-01 0.2690 -1.93e-01 -0.188000 1.68e-01 1.81e-01
Glycosphingolipid metabolism 46 1.03e-02 3.54e-02 0.2690 -2.57e-01 -0.080700 2.59e-03 3.44e-01
Triglyceride biosynthesis 9 4.93e-01 6.11e-01 0.2690 -1.70e-01 -0.208000 3.77e-01 2.79e-01
PKMTs methylate histone lysines 43 6.96e-03 2.58e-02 0.2690 3.49e-02 0.267000 6.92e-01 2.48e-03
tRNA processing in the nucleus 59 2.88e-05 2.94e-04 0.2690 -1.57e-01 0.219000 3.74e-02 3.68e-03
Trafficking of GluR2-containing AMPA receptors 11 1.99e-01 3.17e-01 0.2690 -4.77e-02 0.265000 7.84e-01 1.29e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 9.51e-06 1.16e-04 0.2690 -2.63e-01 -0.057100 2.38e-06 3.05e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 9.51e-06 1.16e-04 0.2690 -2.63e-01 -0.057100 2.38e-06 3.05e-01
VxPx cargo-targeting to cilium 19 6.96e-02 1.47e-01 0.2690 -2.67e-01 0.030700 4.40e-02 8.17e-01
Platelet Adhesion to exposed collagen 15 8.39e-02 1.68e-01 0.2680 2.47e-01 -0.106000 9.82e-02 4.79e-01
Antigen processing-Cross presentation 89 6.46e-05 5.74e-04 0.2680 -2.63e-01 -0.052100 1.78e-05 3.96e-01
Zinc transporters 12 1.19e-01 2.20e-01 0.2680 -1.62e-01 0.214000 3.32e-01 1.99e-01
HDL assembly 6 4.03e-01 5.30e-01 0.2680 -6.42e-02 0.260000 7.86e-01 2.70e-01
PI-3K cascade:FGFR4 11 2.91e-01 4.19e-01 0.2680 -2.65e-01 -0.040900 1.29e-01 8.14e-01
Cargo trafficking to the periciliary membrane 48 7.37e-04 4.35e-03 0.2680 -2.60e-01 0.061800 1.80e-03 4.59e-01
Reactions specific to the complex N-glycan synthesis pathway 7 2.90e-01 4.18e-01 0.2670 -2.09e-01 0.167000 3.39e-01 4.44e-01
Packaging Of Telomere Ends 18 9.95e-02 1.90e-01 0.2670 -2.67e-01 0.002680 4.97e-02 9.84e-01
Oncogenic MAPK signaling 76 3.08e-04 2.08e-03 0.2670 -2.61e-01 -0.055100 8.14e-05 4.06e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 2.58e-02 7.09e-02 0.2670 -8.96e-02 0.252000 4.57e-01 3.67e-02
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 2.58e-02 7.09e-02 0.2670 -8.96e-02 0.252000 4.57e-01 3.67e-02
FCERI mediated MAPK activation 94 4.36e-06 5.87e-05 0.2670 -1.27e-02 0.267000 8.31e-01 7.90e-06
Complement cascade 101 6.94e-06 8.92e-05 0.2670 2.35e-02 0.266000 6.83e-01 3.89e-06
Activation of ATR in response to replication stress 37 9.70e-03 3.37e-02 0.2660 2.67e-03 0.266000 9.78e-01 5.05e-03
HuR (ELAVL1) binds and stabilizes mRNA 10 2.41e-01 3.67e-01 0.2660 -4.24e-02 0.263000 8.16e-01 1.50e-01
Signal amplification 28 3.09e-02 8.22e-02 0.2660 -2.66e-01 -0.004210 1.49e-02 9.69e-01
RHOBTB1 GTPase cycle 23 5.80e-02 1.30e-01 0.2650 -2.65e-01 -0.004310 2.76e-02 9.71e-01
Polymerase switching on the C-strand of the telomere 26 4.05e-02 1.00e-01 0.2650 4.84e-03 0.265000 9.66e-01 1.93e-02
Signaling by FGFR1 in disease 32 1.44e-02 4.61e-02 0.2650 -2.64e-01 0.020400 9.73e-03 8.42e-01
Viral mRNA Translation 87 4.83e-04 3.06e-03 0.2650 -2.42e-01 -0.107000 9.49e-05 8.39e-02
WNT mediated activation of DVL 8 4.64e-01 5.88e-01 0.2650 8.11e-02 0.252000 6.91e-01 2.17e-01
Mucopolysaccharidoses 11 2.72e-01 4.01e-01 0.2640 -2.64e-01 -0.016600 1.30e-01 9.24e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 4.43e-03 1.81e-02 0.2640 -2.64e-01 0.012300 3.06e-03 8.90e-01
Transport of Mature Transcript to Cytoplasm 81 1.26e-06 1.93e-05 0.2640 -1.35e-01 0.227000 3.54e-02 4.08e-04
Metabolism of non-coding RNA 53 2.08e-04 1.47e-03 0.2640 -1.04e-01 0.243000 1.90e-01 2.22e-03
snRNP Assembly 53 2.08e-04 1.47e-03 0.2640 -1.04e-01 0.243000 1.90e-01 2.22e-03
Diseases of hemostasis 14 9.65e-02 1.87e-01 0.2640 2.27e-01 -0.135000 1.42e-01 3.83e-01
Transcriptional regulation by small RNAs 61 2.91e-05 2.95e-04 0.2640 -1.62e-01 0.208000 2.83e-02 5.05e-03
Regulation of IFNG signaling 14 3.28e-01 4.60e-01 0.2630 -2.24e-01 -0.138000 1.46e-01 3.70e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.24e-02 6.49e-02 0.2630 -1.95e-01 0.177000 1.13e-01 1.51e-01
Interaction between L1 and Ankyrins 27 6.92e-02 1.46e-01 0.2630 2.54e-01 0.067900 2.22e-02 5.41e-01
Cellular response to heat stress 94 6.36e-07 1.07e-05 0.2630 -8.11e-02 0.250000 1.74e-01 2.71e-05
Nucleotide catabolism 28 6.17e-02 1.35e-01 0.2630 -2.55e-01 -0.065900 1.96e-02 5.46e-01
PI5P Regulates TP53 Acetylation 8 2.56e-01 3.84e-01 0.2630 -2.11e-01 0.157000 3.02e-01 4.42e-01
Mitophagy 38 3.68e-02 9.31e-02 0.2630 -2.41e-01 -0.106000 1.02e-02 2.60e-01
Inactivation of CSF3 (G-CSF) signaling 24 4.59e-02 1.10e-01 0.2620 -2.62e-01 0.015400 2.63e-02 8.96e-01
Selenoamino acid metabolism 114 1.90e-05 2.02e-04 0.2620 -2.51e-01 -0.074800 3.56e-06 1.68e-01
Signaling by FLT3 fusion proteins 18 6.26e-02 1.36e-01 0.2620 -9.15e-02 0.245000 5.01e-01 7.16e-02
Toll Like Receptor 2 (TLR2) Cascade 109 1.42e-05 1.58e-04 0.2620 -2.56e-01 -0.052700 3.75e-06 3.42e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 1.42e-05 1.58e-04 0.2620 -2.56e-01 -0.052700 3.75e-06 3.42e-01
CD28 dependent PI3K/Akt signaling 22 3.91e-02 9.79e-02 0.2610 -7.17e-02 0.251000 5.60e-01 4.12e-02
FGFR2 ligand binding and activation 9 4.03e-01 5.30e-01 0.2610 2.55e-01 0.057100 1.85e-01 7.67e-01
Negative regulation of NOTCH4 signaling 44 3.91e-03 1.64e-02 0.2610 -2.61e-01 0.012600 2.76e-03 8.85e-01
Formation of WDR5-containing histone-modifying complexes 42 6.98e-03 2.58e-02 0.2610 7.57e-03 0.261000 9.32e-01 3.47e-03
PI3K/AKT activation 8 5.58e-01 6.61e-01 0.2610 -1.78e-01 -0.191000 3.84e-01 3.50e-01
SUMOylation of DNA methylation proteins 16 8.31e-02 1.67e-01 0.2600 -1.03e-01 0.239000 4.78e-01 9.76e-02
Triglyceride catabolism 15 1.30e-01 2.34e-01 0.2600 -2.57e-01 0.041900 8.52e-02 7.79e-01
ADP signalling through P2Y purinoceptor 12 18 9.21e-02 1.80e-01 0.2600 -2.58e-01 0.032800 5.81e-02 8.10e-01
Signaling by PDGFR in disease 19 4.09e-02 1.01e-01 0.2600 -1.80e-01 0.187000 1.74e-01 1.57e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 1.57e-01 2.67e-01 0.2600 -1.81e-01 0.187000 2.99e-01 2.84e-01
Acyl chain remodelling of PS 14 3.39e-01 4.72e-01 0.2590 -1.36e-01 -0.221000 3.79e-01 1.52e-01
Signaling by BMP 23 6.68e-02 1.44e-01 0.2590 -2.59e-01 -0.005500 3.14e-02 9.64e-01
RNA Polymerase I Promoter Escape 45 2.02e-02 6.05e-02 0.2590 -2.41e-01 -0.096200 5.22e-03 2.64e-01
G-protein beta:gamma signalling 29 2.66e-02 7.27e-02 0.2590 -2.58e-01 0.015800 1.60e-02 8.83e-01
Late SARS-CoV-2 Infection Events 64 2.56e-05 2.64e-04 0.2590 -2.03e-01 0.160000 4.91e-03 2.67e-02
Regulation of lipid metabolism by PPARalpha 107 2.12e-07 4.04e-06 0.2590 -7.04e-02 0.249000 2.08e-01 8.57e-06
TRIF-mediated programmed cell death 9 2.32e-01 3.57e-01 0.2590 -2.18e-01 0.140000 2.58e-01 4.68e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.65e-01 2.78e-01 0.2580 -2.58e-01 -0.017600 7.43e-02 9.03e-01
Peptide chain elongation 87 6.86e-04 4.08e-03 0.2580 -2.36e-01 -0.104000 1.37e-04 9.46e-02
Regulation of HSF1-mediated heat shock response 79 3.19e-06 4.48e-05 0.2580 -1.34e-01 0.221000 3.99e-02 6.92e-04
Synthesis of PIPs at the plasma membrane 52 6.36e-04 3.84e-03 0.2580 -2.50e-01 0.065300 1.84e-03 4.16e-01
Maturation of nucleoprotein 9683610 11 1.63e-01 2.75e-01 0.2580 -1.65e-01 0.198000 3.43e-01 2.55e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 5.49e-01 6.57e-01 0.2580 -2.53e-01 -0.051600 2.84e-01 8.27e-01
DNA Damage Reversal 8 3.53e-01 4.85e-01 0.2580 -3.24e-02 0.256000 8.74e-01 2.11e-01
Activation of RAC1 downstream of NMDARs 7 3.80e-01 5.11e-01 0.2570 -2.51e-01 0.056300 2.50e-01 7.97e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 1.50e-01 2.58e-01 0.2570 -2.45e-01 -0.078900 5.22e-02 5.31e-01
Chemokine receptors bind chemokines 41 2.67e-03 1.18e-02 0.2570 2.45e-01 -0.077700 6.63e-03 3.90e-01
Detoxification of Reactive Oxygen Species 30 1.03e-01 1.94e-01 0.2570 -2.19e-01 -0.134000 3.78e-02 2.03e-01
HIV Life Cycle 144 6.45e-11 2.65e-09 0.2570 -1.65e-01 0.197000 6.09e-04 4.66e-05
Intra-Golgi traffic 43 1.19e-03 6.12e-03 0.2570 -2.26e-01 0.123000 1.04e-02 1.64e-01
PI3K events in ERBB2 signaling 11 4.19e-01 5.45e-01 0.2570 -2.27e-01 -0.119000 1.92e-01 4.93e-01
Degradation of AXIN 42 4.79e-03 1.92e-02 0.2560 -2.55e-01 0.028100 4.26e-03 7.53e-01
STING mediated induction of host immune responses 15 1.26e-01 2.28e-01 0.2560 -6.05e-02 0.249000 6.85e-01 9.51e-02
Degradation of GLI1 by the proteasome 46 2.17e-03 1.01e-02 0.2560 -2.52e-01 0.047000 3.16e-03 5.81e-01
Neutrophil degranulation 456 9.99e-24 1.13e-21 0.2560 -2.56e-01 0.004680 7.36e-21 8.64e-01
ERK/MAPK targets 22 6.79e-02 1.44e-01 0.2560 -2.55e-01 0.016300 3.83e-02 8.95e-01
Smooth Muscle Contraction 34 5.56e-02 1.26e-01 0.2550 -2.38e-01 -0.092400 1.62e-02 3.51e-01
Mitotic Prophase 96 2.44e-07 4.62e-06 0.2550 -2.12e-01 0.142000 3.24e-04 1.61e-02
HIV Infection 213 1.36e-15 1.01e-13 0.2550 -1.84e-01 0.176000 3.55e-06 9.22e-06
Elevation of cytosolic Ca2+ levels 13 3.95e-01 5.22e-01 0.2550 2.03e-01 0.154000 2.05e-01 3.36e-01
Response to metal ions 6 6.39e-01 7.29e-01 0.2550 2.17e-01 0.133000 3.56e-01 5.74e-01
Anti-inflammatory response favouring Leishmania parasite infection 133 4.45e-08 1.04e-06 0.2550 -3.49e-02 0.252000 4.87e-01 5.13e-07
Leishmania parasite growth and survival 133 4.45e-08 1.04e-06 0.2550 -3.49e-02 0.252000 4.87e-01 5.13e-07
Late Phase of HIV Life Cycle 131 8.00e-10 2.57e-08 0.2540 -1.63e-01 0.195000 1.26e-03 1.13e-04
Formation of Fibrin Clot (Clotting Cascade) 26 6.15e-02 1.35e-01 0.2540 -2.23e-02 -0.253000 8.44e-01 2.53e-02
Protein ubiquitination 71 8.90e-05 7.44e-04 0.2540 -2.50e-01 0.046400 2.69e-04 4.99e-01
Adipogenesis 95 1.77e-05 1.92e-04 0.2540 -1.11e-03 0.254000 9.85e-01 1.84e-05
SLBP independent Processing of Histone Pre-mRNAs 10 3.34e-01 4.65e-01 0.2540 -2.54e-01 -0.014400 1.65e-01 9.37e-01
Ethanol oxidation 7 3.89e-01 5.18e-01 0.2540 -2.47e-01 0.056900 2.57e-01 7.94e-01
Inositol phosphate metabolism 42 1.46e-03 7.18e-03 0.2530 -1.36e-01 0.214000 1.28e-01 1.64e-02
Activation of NF-kappaB in B cells 54 2.53e-03 1.13e-02 0.2530 -2.53e-01 -0.008710 1.30e-03 9.12e-01
TRAIL signaling 8 3.63e-01 4.94e-01 0.2530 -2.50e-01 0.036300 2.20e-01 8.59e-01
SHC1 events in EGFR signaling 11 3.14e-01 4.46e-01 0.2530 -2.52e-01 -0.023600 1.48e-01 8.92e-01
LDL clearance 17 6.79e-02 1.44e-01 0.2530 -1.62e-01 0.193000 2.46e-01 1.67e-01
Negative regulation of FLT3 15 1.60e-01 2.71e-01 0.2520 -2.58e-02 0.250000 8.63e-01 9.31e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 2.03e-02 6.06e-02 0.2520 -7.79e-02 0.239000 4.76e-01 2.84e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 6.39e-01 7.29e-01 0.2510 -2.20e-01 -0.121000 3.50e-01 6.07e-01
DNA replication initiation 8 2.84e-01 4.14e-01 0.2510 -1.72e-01 0.184000 4.00e-01 3.69e-01
Signal transduction by L1 20 1.48e-01 2.56e-01 0.2510 -2.47e-01 -0.048000 5.62e-02 7.10e-01
PPARA activates gene expression 105 5.76e-07 9.82e-06 0.2510 -7.33e-02 0.240000 1.94e-01 2.11e-05
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 1.26e-05 1.45e-04 0.2510 -2.51e-01 -0.012100 9.07e-06 8.30e-01
Antiviral mechanism by IFN-stimulated genes 140 3.29e-10 1.15e-08 0.2510 -1.82e-01 0.172000 1.97e-04 4.28e-04
Formation of TC-NER Pre-Incision Complex 51 8.91e-04 5.02e-03 0.2510 -2.39e-01 0.076800 3.21e-03 3.42e-01
MAPK6/MAPK4 signaling 69 7.66e-04 4.50e-03 0.2510 -2.50e-01 -0.021600 3.35e-04 7.56e-01
Ca2+ activated K+ channels 6 4.04e-01 5.31e-01 0.2500 2.13e-01 -0.131000 3.66e-01 5.79e-01
Synthesis, secretion, and deacylation of Ghrelin 11 4.74e-01 5.94e-01 0.2500 -1.92e-01 -0.160000 2.69e-01 3.59e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.24e-02 1.81e-01 0.2500 -2.49e-01 0.022300 5.40e-02 8.63e-01
CD28 co-stimulation 33 6.25e-03 2.38e-02 0.2500 -1.98e-01 0.152000 4.89e-02 1.30e-01
Transcription of the HIV genome 67 4.51e-05 4.26e-04 0.2490 -2.14e-01 0.128000 2.45e-03 7.00e-02
Selenocysteine synthesis 91 5.40e-04 3.36e-03 0.2490 -2.35e-01 -0.083400 1.07e-04 1.69e-01
Release of apoptotic factors from the mitochondria 6 4.75e-01 5.94e-01 0.2490 -3.93e-02 0.246000 8.68e-01 2.97e-01
Xenobiotics 12 4.29e-01 5.54e-01 0.2490 1.33e-01 0.210000 4.25e-01 2.08e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 4.47e-04 2.88e-03 0.2480 -2.35e-01 -0.079900 8.87e-05 1.83e-01
Toll Like Receptor 9 (TLR9) Cascade 108 5.03e-06 6.68e-05 0.2480 -2.48e-01 0.010100 8.37e-06 8.56e-01
IL-6-type cytokine receptor ligand interactions 13 2.58e-01 3.86e-01 0.2480 -1.56e-02 -0.248000 9.23e-01 1.22e-01
FOXO-mediated transcription of cell cycle genes 14 2.81e-01 4.10e-01 0.2480 -2.42e-01 -0.054000 1.17e-01 7.26e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 5.45e-01 6.54e-01 0.2480 -2.24e-01 -0.105000 2.72e-01 6.08e-01
MyD88 cascade initiated on plasma membrane 95 1.09e-04 8.69e-04 0.2470 -2.45e-01 -0.036600 3.73e-05 5.38e-01
Toll Like Receptor 10 (TLR10) Cascade 95 1.09e-04 8.69e-04 0.2470 -2.45e-01 -0.036600 3.73e-05 5.38e-01
Toll Like Receptor 5 (TLR5) Cascade 95 1.09e-04 8.69e-04 0.2470 -2.45e-01 -0.036600 3.73e-05 5.38e-01
Arachidonate metabolism 47 1.49e-02 4.75e-02 0.2470 -5.65e-02 -0.241000 5.03e-01 4.31e-03
MECP2 regulates transcription factors 5 7.06e-01 7.85e-01 0.2470 -2.09e-01 -0.132000 4.19e-01 6.09e-01
Pexophagy 10 2.36e-01 3.60e-01 0.2470 -2.19e-01 0.115000 2.31e-01 5.29e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.51e-01 2.60e-01 0.2470 -6.69e-03 0.247000 9.62e-01 7.79e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.51e-01 2.60e-01 0.2470 -6.69e-03 0.247000 9.62e-01 7.79e-02
Glycolysis 68 3.37e-05 3.37e-04 0.2470 -1.72e-01 0.177000 1.41e-02 1.16e-02
Mitochondrial protein degradation 96 1.02e-05 1.22e-04 0.2460 -2.44e-01 0.034400 3.57e-05 5.60e-01
FOXO-mediated transcription of cell death genes 16 2.33e-01 3.57e-01 0.2460 4.95e-02 0.241000 7.32e-01 9.48e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 9.39e-03 3.28e-02 0.2460 -2.46e-01 0.009320 5.79e-03 9.17e-01
Diseases of carbohydrate metabolism 29 6.12e-02 1.35e-01 0.2460 -2.44e-01 -0.033500 2.30e-02 7.55e-01
CDH11 homotypic and heterotypic interactions 5 4.98e-01 6.17e-01 0.2460 -9.82e-02 0.226000 7.04e-01 3.82e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.96e-01 3.13e-01 0.2460 -2.30e-01 0.086500 1.68e-01 6.04e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 2.39e-03 1.09e-02 0.2460 -7.14e-02 0.235000 4.02e-01 5.80e-03
PP2A-mediated dephosphorylation of key metabolic factors 7 5.68e-01 6.68e-01 0.2460 -2.32e-01 -0.081500 2.88e-01 7.09e-01
Circadian Clock 67 4.98e-05 4.64e-04 0.2460 -1.44e-01 0.199000 4.21e-02 4.77e-03
Zinc influx into cells by the SLC39 gene family 9 4.56e-01 5.80e-01 0.2460 5.93e-02 0.238000 7.58e-01 2.16e-01
Unfolded Protein Response (UPR) 85 4.15e-06 5.67e-05 0.2450 -2.06e-01 0.133000 9.99e-04 3.45e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 4.72e-01 5.94e-01 0.2450 -1.67e-01 0.180000 5.18e-01 4.86e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 2.60e-03 1.16e-02 0.2450 -2.44e-01 0.028100 2.61e-03 7.29e-01
FLT3 Signaling 38 3.45e-03 1.49e-02 0.2450 -1.66e-01 0.180000 7.63e-02 5.50e-02
Transcriptional activation of mitochondrial biogenesis 52 7.38e-04 4.35e-03 0.2440 -1.03e-01 0.222000 1.99e-01 5.66e-03
Vif-mediated degradation of APOBEC3G 41 1.12e-02 3.79e-02 0.2440 -2.44e-01 0.009830 6.85e-03 9.13e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 1.75e-01 2.89e-01 0.2440 -2.03e-01 -0.135000 7.28e-02 2.33e-01
Ubiquitin-dependent degradation of Cyclin D 39 2.06e-02 6.11e-02 0.2440 -2.43e-01 -0.018700 8.56e-03 8.40e-01
MAP2K and MAPK activation 36 3.53e-02 9.01e-02 0.2440 -2.41e-01 -0.038000 1.24e-02 6.93e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 5.80e-05 5.35e-04 0.2440 -2.43e-01 -0.023400 2.72e-05 6.86e-01
Base Excision Repair 57 1.02e-03 5.55e-03 0.2430 -4.61e-02 0.239000 5.47e-01 1.81e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 11 4.44e-01 5.69e-01 0.2430 -2.22e-01 -0.100000 2.03e-01 5.65e-01
ERKs are inactivated 13 1.90e-01 3.06e-01 0.2430 -2.32e-01 0.069300 1.47e-01 6.65e-01
ADP signalling through P2Y purinoceptor 1 21 1.00e-01 1.91e-01 0.2430 -2.42e-01 0.013800 5.47e-02 9.13e-01
Insulin processing 19 1.45e-01 2.52e-01 0.2420 -2.42e-01 -0.007900 6.79e-02 9.52e-01
AURKA Activation by TPX2 72 6.07e-04 3.69e-03 0.2420 3.50e-03 0.242000 9.59e-01 3.84e-04
Eukaryotic Translation Elongation 92 1.17e-03 6.12e-03 0.2420 -2.21e-01 -0.096900 2.41e-04 1.08e-01
MET receptor recycling 9 4.65e-01 5.88e-01 0.2420 -2.35e-01 -0.057200 2.23e-01 7.66e-01
Transcriptional Regulation by E2F6 34 8.72e-03 3.10e-02 0.2420 -2.10e-01 0.119000 3.41e-02 2.28e-01
RAF-independent MAPK1/3 activation 22 8.84e-02 1.75e-01 0.2420 -2.41e-01 0.018500 5.05e-02 8.81e-01
Glutamate Neurotransmitter Release Cycle 19 2.90e-01 4.18e-01 0.2410 1.99e-01 0.137000 1.33e-01 3.01e-01
Inwardly rectifying K+ channels 23 2.27e-01 3.52e-01 0.2410 -1.41e-01 -0.196000 2.42e-01 1.04e-01
Regulation of RUNX1 Expression and Activity 18 1.67e-01 2.80e-01 0.2410 1.20e-02 0.241000 9.30e-01 7.70e-02
Transcriptional regulation of white adipocyte differentiation 77 3.62e-04 2.38e-03 0.2410 1.26e-04 0.241000 9.98e-01 2.60e-04
Telomere Maintenance 78 8.58e-05 7.28e-04 0.2410 -5.13e-02 0.235000 4.33e-01 3.29e-04
DARPP-32 events 22 6.21e-02 1.36e-01 0.2410 -2.30e-01 0.070900 6.18e-02 5.65e-01
Asymmetric localization of PCP proteins 49 4.19e-03 1.73e-02 0.2410 -2.39e-01 0.025700 3.76e-03 7.56e-01
Notch-HLH transcription pathway 28 7.23e-02 1.50e-01 0.2400 2.62e-02 0.239000 8.10e-01 2.88e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 1.54e-02 4.87e-02 0.2400 -2.40e-01 0.013200 9.59e-03 8.86e-01
p53-Independent DNA Damage Response 39 1.54e-02 4.87e-02 0.2400 -2.40e-01 0.013200 9.59e-03 8.86e-01
p53-Independent G1/S DNA damage checkpoint 39 1.54e-02 4.87e-02 0.2400 -2.40e-01 0.013200 9.59e-03 8.86e-01
Eukaryotic Translation Termination 91 9.13e-04 5.10e-03 0.2400 -2.27e-01 -0.079300 1.87e-04 1.91e-01
Interleukin-1 signaling 99 1.83e-04 1.34e-03 0.2400 -2.35e-01 -0.045800 5.14e-05 4.31e-01
Transcriptional Regulation by NPAS4 27 5.14e-02 1.20e-01 0.2400 -2.39e-01 0.022000 3.17e-02 8.43e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 6.49e-01 7.37e-01 0.2400 -1.59e-01 -0.179000 4.66e-01 4.11e-01
Basigin interactions 21 8.37e-02 1.68e-01 0.2390 -4.83e-02 0.234000 7.01e-01 6.29e-02
RHOBTB GTPase Cycle 35 1.39e-02 4.47e-02 0.2390 -2.31e-01 0.061600 1.79e-02 5.28e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.84e-01 3.00e-01 0.2390 1.49e-01 -0.187000 3.72e-01 2.63e-01
Reversal of alkylation damage by DNA dioxygenases 7 5.07e-01 6.24e-01 0.2390 1.29e-02 0.238000 9.53e-01 2.75e-01
Cytosolic sulfonation of small molecules 18 2.53e-01 3.81e-01 0.2380 -2.25e-01 -0.077000 9.81e-02 5.72e-01
Activated NTRK2 signals through FRS2 and FRS3 8 3.89e-01 5.18e-01 0.2380 -2.32e-01 0.052800 2.57e-01 7.96e-01
Asparagine N-linked glycosylation 286 2.09e-17 1.83e-15 0.2370 -2.03e-01 0.123000 3.32e-09 3.57e-04
M-decay: degradation of maternal mRNAs by maternally stored factors 41 6.49e-03 2.45e-02 0.2370 -2.26e-01 0.072000 1.24e-02 4.25e-01
tRNA processing in the mitochondrion 24 1.66e-01 2.78e-01 0.2370 -2.23e-01 -0.079100 5.84e-02 5.03e-01
DNA Double Strand Break Response 47 3.06e-03 1.34e-02 0.2360 -7.44e-02 0.224000 3.78e-01 7.75e-03
MyD88 dependent cascade initiated on endosome 101 7.52e-05 6.49e-04 0.2360 -2.36e-01 -0.015100 4.23e-05 7.92e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 4.73e-01 5.94e-01 0.2360 -2.31e-01 -0.049400 2.30e-01 7.98e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.27e-01 3.52e-01 0.2360 -1.24e-01 0.201000 4.75e-01 2.49e-01
Effects of PIP2 hydrolysis 24 1.73e-01 2.88e-01 0.2360 8.31e-02 0.221000 4.81e-01 6.13e-02
Signaling by NTRK1 (TRKA) 102 7.90e-05 6.76e-04 0.2360 -2.35e-01 -0.018300 4.07e-05 7.49e-01
Downstream signaling events of B Cell Receptor (BCR) 68 9.15e-04 5.10e-03 0.2360 -2.35e-01 0.012300 7.87e-04 8.61e-01
Regulation of PTEN stability and activity 55 8.71e-03 3.10e-02 0.2360 -2.33e-01 -0.038100 2.84e-03 6.25e-01
Diseases associated with glycosylation precursor biosynthesis 15 1.92e-01 3.08e-01 0.2360 -3.41e-02 0.233000 8.19e-01 1.18e-01
Aflatoxin activation and detoxification 14 2.33e-01 3.57e-01 0.2350 -2.35e-01 0.016100 1.28e-01 9.17e-01
Synthesis of IP3 and IP4 in the cytosol 22 4.86e-02 1.15e-01 0.2350 -1.53e-01 0.178000 2.13e-01 1.47e-01
Anchoring fibril formation 8 5.49e-01 6.57e-01 0.2350 -7.46e-02 -0.223000 7.15e-01 2.74e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 2.14e-01 3.34e-01 0.2350 -2.27e-01 0.062100 1.57e-01 6.98e-01
SARS-CoV-1 modulates host translation machinery 36 9.76e-02 1.88e-01 0.2350 -2.04e-01 -0.116000 3.39e-02 2.28e-01
Cobalamin (Cbl) metabolism 7 4.15e-01 5.41e-01 0.2350 -2.17e-01 0.088900 3.19e-01 6.84e-01
APC/C:Cdc20 mediated degradation of Securin 55 1.15e-02 3.86e-02 0.2350 -2.29e-01 -0.051300 3.32e-03 5.10e-01
Glucose metabolism 76 3.48e-05 3.46e-04 0.2340 -1.40e-01 0.188000 3.44e-02 4.63e-03
CRMPs in Sema3A signaling 14 1.85e-01 3.01e-01 0.2340 -7.08e-02 0.224000 6.46e-01 1.48e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 37 4.16e-02 1.02e-01 0.2340 -2.32e-01 -0.035700 1.48e-02 7.07e-01
BBSome-mediated cargo-targeting to cilium 23 8.48e-02 1.69e-01 0.2340 -2.32e-01 0.029500 5.39e-02 8.07e-01
IRAK2 mediated activation of TAK1 complex 10 5.03e-01 6.22e-01 0.2340 -2.14e-01 -0.095600 2.42e-01 6.01e-01
O-glycosylation of TSR domain-containing proteins 28 1.83e-01 2.99e-01 0.2340 1.90e-01 0.137000 8.22e-02 2.10e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 4.05e-03 1.69e-02 0.2340 -2.32e-01 -0.025000 1.55e-03 7.33e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.42e-01 2.48e-01 0.2340 -2.27e-01 0.054200 1.05e-01 6.99e-01
Complex III assembly 23 6.97e-02 1.47e-01 0.2330 -2.26e-01 0.059300 6.12e-02 6.23e-01
Signalling to ERKs 32 5.92e-02 1.32e-01 0.2330 -2.32e-01 -0.025000 2.34e-02 8.07e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 3.47e-01 4.80e-01 0.2330 2.17e-01 0.085000 1.46e-01 5.69e-01
Defensins 8 4.34e-01 5.60e-01 0.2330 -2.32e-01 0.023100 2.56e-01 9.10e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 1.19e-02 3.95e-02 0.2330 -2.29e-01 -0.043900 3.67e-03 5.77e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 2.86e-01 4.15e-01 0.2320 -2.00e-01 -0.117000 1.21e-01 3.64e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.22e-16 1.03e-14 0.2320 -1.41e-01 0.184000 5.23e-05 1.14e-07
Transport to the Golgi and subsequent modification 171 1.31e-10 5.17e-09 0.2320 -1.57e-01 0.171000 4.04e-04 1.15e-04
Inactivation, recovery and regulation of the phototransduction cascade 26 6.16e-02 1.35e-01 0.2320 3.58e-02 -0.229000 7.52e-01 4.34e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 6.54e-01 7.40e-01 0.2320 -2.17e-01 -0.081000 3.57e-01 7.31e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.81e-01 2.96e-01 0.2310 3.04e-02 0.229000 8.14e-01 7.58e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 4.79e-01 5.98e-01 0.2310 -2.31e-01 -0.009900 2.58e-01 9.61e-01
RNA Polymerase I Transcription Termination 30 9.16e-02 1.79e-01 0.2310 -2.26e-01 -0.047900 3.22e-02 6.50e-01
COPI-independent Golgi-to-ER retrograde traffic 45 1.13e-02 3.83e-02 0.2310 -2.30e-01 0.014400 7.47e-03 8.68e-01
Translation 292 1.24e-12 6.65e-11 0.2310 -2.31e-01 0.000396 1.15e-11 9.91e-01
DNA Repair 289 2.53e-16 2.03e-14 0.2310 -1.06e-01 0.205000 1.96e-03 1.99e-09
Heme degradation 10 5.64e-01 6.64e-01 0.2310 1.74e-01 0.152000 3.42e-01 4.06e-01
G beta:gamma signalling through PLC beta 17 1.30e-01 2.33e-01 0.2310 -2.15e-01 0.083600 1.25e-01 5.51e-01
Presynaptic function of Kainate receptors 17 1.30e-01 2.33e-01 0.2310 -2.15e-01 0.083600 1.25e-01 5.51e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 3.27e-01 4.59e-01 0.2300 2.14e-02 -0.229000 9.02e-01 1.88e-01
Triglyceride metabolism 24 1.54e-01 2.64e-01 0.2300 -2.24e-01 -0.052000 5.71e-02 6.59e-01
RHOH GTPase cycle 33 5.56e-02 1.26e-01 0.2300 -2.29e-01 -0.021000 2.26e-02 8.35e-01
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.09e-02 8.22e-02 0.2300 -2.29e-01 0.016000 1.88e-02 8.70e-01
Cellular response to hypoxia 59 2.20e-03 1.01e-02 0.2300 -2.28e-01 0.030400 2.47e-03 6.86e-01
Stabilization of p53 43 1.94e-02 5.86e-02 0.2290 -2.29e-01 -0.005970 9.27e-03 9.46e-01
SUMOylation of transcription cofactors 44 3.64e-03 1.55e-02 0.2290 -1.25e-01 0.192000 1.51e-01 2.75e-02
Neurotransmitter clearance 5 7.48e-01 8.18e-01 0.2290 -1.36e-01 -0.185000 5.98e-01 4.75e-01
FLT3 signaling in disease 27 3.62e-02 9.18e-02 0.2290 -1.01e-01 0.205000 3.62e-01 6.46e-02
Regulation of CDH11 Expression and Function 22 1.57e-01 2.67e-01 0.2290 2.85e-02 0.227000 8.17e-01 6.52e-02
Regulation of KIT signaling 15 1.42e-01 2.48e-01 0.2290 -1.73e-01 0.150000 2.46e-01 3.16e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 4.57e-03 1.85e-02 0.2290 -1.35e-01 0.185000 1.31e-01 3.82e-02
HIV Transcription Elongation 42 4.57e-03 1.85e-02 0.2290 -1.35e-01 0.185000 1.31e-01 3.82e-02
Tat-mediated elongation of the HIV-1 transcript 42 4.57e-03 1.85e-02 0.2290 -1.35e-01 0.185000 1.31e-01 3.82e-02
FasL/ CD95L signaling 5 5.63e-01 6.64e-01 0.2290 -2.17e-01 0.070400 4.00e-01 7.85e-01
Role of second messengers in netrin-1 signaling 6 7.12e-01 7.90e-01 0.2280 1.46e-01 0.176000 5.36e-01 4.56e-01
Regulation of PTEN mRNA translation 13 1.85e-01 3.01e-01 0.2280 -1.67e-01 0.156000 2.97e-01 3.31e-01
Influenza Infection 153 4.00e-08 9.75e-07 0.2280 -2.19e-01 0.062100 2.80e-06 1.85e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.68e-03 1.56e-02 0.2280 -1.33e-01 0.185000 1.28e-01 3.33e-02
ABC transporters in lipid homeostasis 14 3.02e-01 4.33e-01 0.2280 2.27e-01 0.021300 1.42e-01 8.90e-01
HDACs deacetylate histones 45 9.05e-03 3.19e-02 0.2270 -3.94e-02 0.224000 6.47e-01 9.33e-03
Regulation of RUNX3 expression and activity 45 1.49e-02 4.75e-02 0.2270 -2.27e-01 0.004790 8.34e-03 9.56e-01
RHOC GTPase cycle 71 2.99e-04 2.03e-03 0.2270 -7.37e-02 0.215000 2.83e-01 1.73e-03
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 5.42e-02 1.24e-01 0.2270 -1.83e-01 0.134000 1.28e-01 2.65e-01
Formation of RNA Pol II elongation complex 56 8.86e-04 5.01e-03 0.2270 -1.28e-01 0.187000 9.64e-02 1.55e-02
RNA Polymerase II Transcription Elongation 56 8.86e-04 5.01e-03 0.2270 -1.28e-01 0.187000 9.64e-02 1.55e-02
Clathrin-mediated endocytosis 126 1.85e-07 3.56e-06 0.2270 -1.95e-01 0.116000 1.55e-04 2.51e-02
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.56e-01 2.66e-01 0.2270 -2.22e-01 -0.044700 5.96e-02 7.05e-01
Josephin domain DUBs 10 3.53e-01 4.84e-01 0.2260 -2.23e-01 0.040700 2.23e-01 8.24e-01
SARS-CoV-2 Infection 267 3.74e-15 2.67e-13 0.2260 -1.82e-01 0.134000 3.16e-07 1.57e-04
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.37e-01 5.61e-01 0.2260 9.34e-02 0.206000 5.60e-01 1.99e-01
Toll-like Receptor Cascades 162 1.59e-07 3.26e-06 0.2260 -2.25e-01 0.019600 7.60e-07 6.67e-01
RHOB GTPase cycle 64 2.47e-03 1.11e-02 0.2260 -9.69e-03 0.226000 8.93e-01 1.80e-03
Miro GTPase Cycle 8 6.15e-01 7.09e-01 0.2260 -1.99e-01 -0.107000 3.30e-01 6.02e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 5.16e-01 6.31e-01 0.2260 1.44e-01 0.173000 3.86e-01 2.98e-01
TP53 Regulates Metabolic Genes 78 5.85e-04 3.59e-03 0.2260 -2.25e-01 0.015700 5.88e-04 8.11e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 5.75e-01 6.75e-01 0.2250 -2.15e-01 0.066100 4.04e-01 7.98e-01
Acyl chain remodelling of PC 19 2.59e-01 3.87e-01 0.2250 -2.16e-01 -0.062500 1.03e-01 6.37e-01
Rap1 signalling 14 3.29e-01 4.60e-01 0.2250 -2.22e-01 -0.034300 1.50e-01 8.24e-01
Signaling by NOTCH4 68 1.64e-03 7.95e-03 0.2250 -2.25e-01 0.013400 1.36e-03 8.48e-01
ER to Golgi Anterograde Transport 145 1.31e-08 3.61e-07 0.2250 -1.68e-01 0.149000 4.74e-04 1.89e-03
Phase 4 - resting membrane potential 9 3.82e-01 5.11e-01 0.2250 -5.48e-02 0.218000 7.76e-01 2.57e-01
NIK–>noncanonical NF-kB signaling 46 1.21e-02 4.00e-02 0.2250 -2.24e-01 0.019300 8.57e-03 8.21e-01
Signaling by Non-Receptor Tyrosine Kinases 47 3.14e-03 1.37e-02 0.2250 -1.88e-01 0.124000 2.61e-02 1.43e-01
Signaling by PTK6 47 3.14e-03 1.37e-02 0.2250 -1.88e-01 0.124000 2.61e-02 1.43e-01
Regulation of RUNX2 expression and activity 54 1.10e-02 3.74e-02 0.2250 -2.24e-01 -0.019300 4.45e-03 8.06e-01
Mitochondrial tRNA aminoacylation 21 1.38e-01 2.44e-01 0.2240 -1.56e-02 0.224000 9.02e-01 7.60e-02
Glycerophospholipid catabolism 7 4.91e-01 6.10e-01 0.2240 2.21e-01 -0.038300 3.12e-01 8.61e-01
SLC transporter disorders 76 1.92e-04 1.39e-03 0.2230 -8.17e-02 0.208000 2.18e-01 1.74e-03
RNA Polymerase II Pre-transcription Events 77 8.77e-05 7.38e-04 0.2230 -1.85e-01 0.125000 5.03e-03 5.77e-02
HS-GAG biosynthesis 21 9.43e-02 1.83e-01 0.2230 -8.06e-02 0.208000 5.23e-01 9.88e-02
Proteasome assembly 51 6.65e-03 2.49e-02 0.2230 -2.20e-01 0.032100 6.47e-03 6.91e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.37e-02 4.43e-02 0.2230 -2.22e-01 -0.018300 5.63e-03 8.19e-01
mRNA Splicing - Major Pathway 203 2.50e-11 1.15e-09 0.2220 -1.29e-01 0.181000 1.53e-03 8.71e-06
EPH-Ephrin signaling 81 7.72e-05 6.64e-04 0.2220 -1.95e-01 0.106000 2.37e-03 1.00e-01
DNA Double-Strand Break Repair 137 4.53e-07 8.08e-06 0.2220 -6.39e-02 0.213000 1.96e-01 1.72e-05
p53-Dependent G1 DNA Damage Response 52 8.14e-03 2.92e-02 0.2220 -2.21e-01 0.015400 5.72e-03 8.48e-01
p53-Dependent G1/S DNA damage checkpoint 52 8.14e-03 2.92e-02 0.2220 -2.21e-01 0.015400 5.72e-03 8.48e-01
ALK mutants bind TKIs 11 2.61e-01 3.88e-01 0.2220 -1.43e-01 0.170000 4.12e-01 3.29e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 6.38e-01 7.29e-01 0.2220 -2.18e-01 -0.041300 3.56e-01 8.61e-01
Defective B3GALTL causes PpS 27 2.25e-01 3.48e-01 0.2220 1.85e-01 0.122000 9.68e-02 2.71e-01
Displacement of DNA glycosylase by APEX1 9 5.82e-01 6.80e-01 0.2210 9.65e-02 0.199000 6.16e-01 3.00e-01
Apoptotic cleavage of cellular proteins 35 3.12e-02 8.26e-02 0.2210 -2.18e-01 0.037900 2.55e-02 6.98e-01
Cell death signalling via NRAGE, NRIF and NADE 69 1.08e-03 5.76e-03 0.2210 -3.84e-02 0.218000 5.81e-01 1.73e-03
Mitochondrial protein import 63 7.17e-03 2.63e-02 0.2210 -2.19e-01 -0.027700 2.59e-03 7.04e-01
GDP-fucose biosynthesis 6 5.36e-01 6.46e-01 0.2210 -5.59e-02 0.214000 8.13e-01 3.65e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 5.49e-04 3.40e-03 0.2210 -1.65e-01 0.147000 2.49e-02 4.51e-02
Protein methylation 15 3.72e-01 5.03e-01 0.2210 -2.09e-01 -0.070300 1.61e-01 6.37e-01
SARS-CoV Infections 434 2.29e-22 2.32e-20 0.2200 -1.12e-01 0.190000 5.93e-05 1.23e-11
Listeria monocytogenes entry into host cells 17 2.15e-01 3.36e-01 0.2200 -2.20e-01 0.013000 1.17e-01 9.26e-01
Reelin signalling pathway 5 6.45e-01 7.34e-01 0.2200 2.20e-01 -0.004970 3.94e-01 9.85e-01
Autodegradation of the E3 ubiquitin ligase COP1 38 3.29e-02 8.48e-02 0.2200 -2.19e-01 0.012700 1.93e-02 8.92e-01
Regulation of Expression and Function of Type II Classical Cadherins 24 2.06e-01 3.24e-01 0.2200 6.74e-02 0.209000 5.68e-01 7.64e-02
Regulation of Homotypic Cell-Cell Adhesion 24 2.06e-01 3.24e-01 0.2200 6.74e-02 0.209000 5.68e-01 7.64e-02
Phase II - Conjugation of compounds 70 2.17e-02 6.31e-02 0.2200 -1.85e-01 -0.118000 7.36e-03 8.84e-02
Glycerophospholipid biosynthesis 105 4.64e-04 2.97e-03 0.2190 -2.16e-01 -0.040700 1.34e-04 4.71e-01
Peptide hormone metabolism 53 5.80e-02 1.30e-01 0.2190 -1.81e-01 -0.124000 2.28e-02 1.18e-01
Dopamine Neurotransmitter Release Cycle 18 3.86e-01 5.16e-01 0.2190 1.32e-01 0.175000 3.34e-01 1.98e-01
Loss of Nlp from mitotic centrosomes 69 1.89e-03 8.90e-03 0.2190 -1.86e-02 0.218000 7.90e-01 1.73e-03
Loss of proteins required for interphase microtubule organization from the centrosome 69 1.89e-03 8.90e-03 0.2190 -1.86e-02 0.218000 7.90e-01 1.73e-03
Regulation of mRNA stability by proteins that bind AU-rich elements 76 7.81e-04 4.58e-03 0.2190 -2.17e-01 0.029500 1.08e-03 6.57e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 2.75e-02 7.44e-02 0.2190 -2.19e-01 0.007840 1.54e-02 9.31e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 2.53e-01 3.81e-01 0.2190 -1.90e-01 0.109000 2.55e-01 5.15e-01
Regulation of TP53 Activity 153 1.71e-08 4.64e-07 0.2190 -1.29e-01 0.177000 5.99e-03 1.60e-04
Endosomal Sorting Complex Required For Transport (ESCRT) 29 3.16e-02 8.28e-02 0.2190 -1.54e-01 0.156000 1.52e-01 1.47e-01
SARS-CoV-2-host interactions 182 7.01e-10 2.29e-08 0.2190 -1.82e-01 0.122000 2.34e-05 4.63e-03
Negative epigenetic regulation of rRNA expression 63 3.29e-03 1.42e-02 0.2180 -2.18e-01 0.019200 2.82e-03 7.92e-01
CDK-mediated phosphorylation and removal of Cdc6 60 7.56e-03 2.73e-02 0.2180 -2.18e-01 -0.011000 3.47e-03 8.83e-01
Activated NTRK2 signals through RAS 6 5.55e-01 6.61e-01 0.2180 -2.14e-01 0.043700 3.64e-01 8.53e-01
Activated NTRK3 signals through RAS 6 5.55e-01 6.61e-01 0.2180 -2.14e-01 0.043700 3.64e-01 8.53e-01
Signaling by SCF-KIT 40 9.07e-03 3.19e-02 0.2180 -1.71e-01 0.136000 6.14e-02 1.38e-01
DNA Damage Recognition in GG-NER 38 1.15e-02 3.86e-02 0.2180 -1.38e-01 0.169000 1.42e-01 7.14e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 4.28e-02 1.04e-01 0.2180 -2.16e-01 -0.024300 1.65e-02 7.88e-01
Signaling by RAS mutants 41 4.28e-02 1.04e-01 0.2180 -2.16e-01 -0.024300 1.65e-02 7.88e-01
Signaling by moderate kinase activity BRAF mutants 41 4.28e-02 1.04e-01 0.2180 -2.16e-01 -0.024300 1.65e-02 7.88e-01
Signaling downstream of RAS mutants 41 4.28e-02 1.04e-01 0.2180 -2.16e-01 -0.024300 1.65e-02 7.88e-01
Gene Silencing by RNA 87 3.70e-05 3.58e-04 0.2170 -1.62e-01 0.146000 9.18e-03 1.89e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 1.58e-01 2.69e-01 0.2170 5.32e-02 0.211000 6.32e-01 5.79e-02
NoRC negatively regulates rRNA expression 60 6.87e-03 2.55e-02 0.2170 -2.17e-01 -0.003340 3.59e-03 9.64e-01
Diseases associated with N-glycosylation of proteins 20 1.95e-01 3.13e-01 0.2170 -2.17e-01 -0.008020 9.26e-02 9.50e-01
Diseases associated with glycosaminoglycan metabolism 26 6.34e-02 1.38e-01 0.2170 -2.03e-01 0.076400 7.26e-02 5.00e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 2.79e-01 4.09e-01 0.2170 -2.15e-01 -0.029000 1.24e-01 8.36e-01
Signaling by ROBO receptors 188 5.58e-07 9.68e-06 0.2170 -2.16e-01 -0.022300 3.26e-07 5.99e-01
p75NTR signals via NF-kB 15 3.14e-01 4.46e-01 0.2170 -2.16e-01 -0.021700 1.48e-01 8.84e-01
Inhibition of DNA recombination at telomere 33 2.36e-02 6.71e-02 0.2170 -1.85e-01 0.113000 6.54e-02 2.62e-01
Sema3A PAK dependent Axon repulsion 16 2.81e-01 4.10e-01 0.2170 1.38e-02 0.216000 9.24e-01 1.34e-01
SARS-CoV-1 activates/modulates innate immune responses 40 1.21e-02 4.01e-02 0.2170 -9.81e-02 0.193000 2.83e-01 3.46e-02
Laminin interactions 26 8.46e-02 1.69e-01 0.2160 3.83e-02 -0.213000 7.35e-01 6.01e-02
TNFR1-mediated ceramide production 6 5.68e-01 6.68e-01 0.2160 -3.56e-02 0.213000 8.80e-01 3.65e-01
Synaptic adhesion-like molecules 17 3.66e-01 4.97e-01 0.2160 8.62e-02 0.198000 5.38e-01 1.57e-01
Plasma lipoprotein assembly 10 3.15e-01 4.47e-01 0.2160 -1.34e-01 0.169000 4.62e-01 3.54e-01
Cellular response to starvation 147 9.54e-05 7.86e-04 0.2160 -2.05e-01 -0.067800 1.78e-05 1.56e-01
Maturation of nucleoprotein 9694631 15 1.77e-01 2.91e-01 0.2160 -1.38e-01 0.166000 3.53e-01 2.67e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 5.24e-01 6.37e-01 0.2160 3.09e-02 -0.214000 8.88e-01 3.28e-01
Regulation of expression of SLITs and ROBOs 148 2.06e-05 2.18e-04 0.2150 -2.13e-01 -0.030900 7.53e-06 5.16e-01
Signaling by ERBB2 44 1.73e-02 5.34e-02 0.2150 -2.13e-01 0.032200 1.45e-02 7.12e-01
Ras activation upon Ca2+ influx through NMDA receptor 18 2.29e-01 3.54e-01 0.2150 2.15e-01 0.002060 1.14e-01 9.88e-01
DNA Damage Bypass 47 4.54e-03 1.84e-02 0.2150 -1.62e-01 0.142000 5.47e-02 9.33e-02
Acyl chain remodeling of CL 5 6.23e-01 7.16e-01 0.2150 -2.11e-01 0.041400 4.14e-01 8.73e-01
Formation of the Early Elongation Complex 33 2.32e-02 6.63e-02 0.2150 -1.36e-01 0.166000 1.76e-01 9.87e-02
Formation of the HIV-1 Early Elongation Complex 33 2.32e-02 6.63e-02 0.2150 -1.36e-01 0.166000 1.76e-01 9.87e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.96e-04 1.41e-03 0.2140 -1.76e-01 0.123000 8.02e-03 6.42e-02
Signaling by RAF1 mutants 37 8.02e-02 1.63e-01 0.2140 -2.09e-01 -0.045300 2.76e-02 6.34e-01
G1/S DNA Damage Checkpoints 54 8.61e-03 3.07e-02 0.2140 -2.13e-01 0.021900 6.80e-03 7.81e-01
NOD1/2 Signaling Pathway 36 1.05e-01 1.99e-01 0.2130 -2.03e-01 -0.064600 3.46e-02 5.03e-01
Processing of Intronless Pre-mRNAs 20 1.39e-01 2.45e-01 0.2130 -2.05e-01 0.060300 1.13e-01 6.41e-01
SHC1 events in ERBB2 signaling 17 3.44e-01 4.77e-01 0.2130 -2.04e-01 -0.063100 1.46e-01 6.52e-01
HCMV Late Events 67 5.75e-04 3.54e-03 0.2130 -1.24e-01 0.174000 7.95e-02 1.40e-02
SCF-beta-TrCP mediated degradation of Emi1 42 1.78e-02 5.47e-02 0.2130 -2.07e-01 0.051100 2.03e-02 5.67e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 3.44e-01 4.77e-01 0.2130 -2.06e-01 0.054700 2.37e-01 7.53e-01
Signaling by Retinoic Acid 29 6.60e-02 1.42e-01 0.2130 -4.37e-02 0.209000 6.84e-01 5.19e-02
Dual incision in TC-NER 63 1.11e-03 5.89e-03 0.2130 -1.86e-01 0.103000 1.06e-02 1.55e-01
Interleukin-1 family signaling 127 1.72e-04 1.26e-03 0.2130 -2.09e-01 -0.041300 4.76e-05 4.21e-01
Signaling by ALK fusions and activated point mutants 89 2.82e-04 1.93e-03 0.2130 -3.81e-02 0.210000 5.35e-01 6.34e-04
Signaling by ALK in cancer 89 2.82e-04 1.93e-03 0.2130 -3.81e-02 0.210000 5.35e-01 6.34e-04
DAP12 signaling 28 7.35e-02 1.52e-01 0.2130 -4.25e-02 0.209000 6.97e-01 5.61e-02
MTOR signalling 39 1.29e-02 4.22e-02 0.2130 -1.69e-01 0.130000 6.81e-02 1.62e-01
Cargo recognition for clathrin-mediated endocytosis 87 4.50e-04 2.89e-03 0.2130 -2.11e-01 0.027300 6.68e-04 6.59e-01
Adenylate cyclase inhibitory pathway 11 3.90e-01 5.19e-01 0.2120 -1.70e-02 0.212000 9.22e-01 2.24e-01
Interferon Signaling 240 4.33e-12 2.04e-10 0.2120 -1.19e-01 0.176000 1.55e-03 2.56e-06
Activation of Ca-permeable Kainate Receptor 9 4.39e-01 5.63e-01 0.2120 2.09e-01 -0.038100 2.78e-01 8.43e-01
Ionotropic activity of kainate receptors 9 4.39e-01 5.63e-01 0.2120 2.09e-01 -0.038100 2.78e-01 8.43e-01
Cristae formation 33 7.56e-02 1.55e-01 0.2120 -2.12e-01 -0.005590 3.52e-02 9.56e-01
Intrinsic Pathway of Fibrin Clot Formation 15 2.31e-01 3.56e-01 0.2120 6.15e-02 -0.203000 6.80e-01 1.74e-01
mRNA Splicing 211 1.02e-10 4.10e-09 0.2120 -1.24e-01 0.172000 1.94e-03 1.73e-05
mTORC1-mediated signalling 24 1.45e-01 2.52e-01 0.2110 -2.11e-01 0.003130 7.31e-02 9.79e-01
Glucagon-type ligand receptors 20 2.24e-01 3.47e-01 0.2110 1.53e-02 0.211000 9.06e-01 1.03e-01
Early SARS-CoV-2 Infection Events 32 3.02e-02 8.05e-02 0.2110 -1.69e-01 0.126000 9.71e-02 2.19e-01
Protein localization 157 1.91e-06 2.80e-05 0.2110 -2.10e-01 0.017400 5.51e-06 7.06e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 1.23e-02 4.04e-02 0.2110 -2.10e-01 -0.018700 4.94e-03 8.02e-01
FGFR2c ligand binding and activation 5 5.82e-01 6.80e-01 0.2110 1.17e-01 -0.175000 6.50e-01 4.98e-01
mRNA Editing 8 6.60e-01 7.45e-01 0.2100 1.04e-01 0.183000 6.11e-01 3.70e-01
Recycling of eIF2:GDP 8 6.83e-01 7.65e-01 0.2100 -1.57e-01 -0.140000 4.41e-01 4.94e-01
Cell surface interactions at the vascular wall 173 6.35e-08 1.46e-06 0.2100 -6.30e-02 0.200000 1.53e-01 5.50e-06
Viral Infection Pathways 775 1.81e-36 5.82e-34 0.2100 -1.40e-01 0.156000 2.89e-11 1.42e-13
RAB GEFs exchange GTP for GDP on RABs 88 8.76e-05 7.38e-04 0.2090 -1.75e-01 0.114000 4.45e-03 6.41e-02
Nuclear Envelope (NE) Reassembly 68 6.58e-04 3.94e-03 0.2090 -1.66e-01 0.128000 1.81e-02 6.87e-02
Sphingolipid metabolism 92 3.70e-03 1.57e-02 0.2090 -2.01e-01 -0.059100 8.84e-04 3.28e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 5.30e-02 1.22e-01 0.2090 -1.48e-01 0.147000 1.82e-01 1.85e-01
Influenza Viral RNA Transcription and Replication 134 4.12e-06 5.67e-05 0.2090 -2.02e-01 0.053000 5.33e-05 2.89e-01
Organic cation transport 8 6.54e-01 7.40e-01 0.2090 -9.31e-02 -0.187000 6.48e-01 3.60e-01
Organic cation/anion/zwitterion transport 8 6.54e-01 7.40e-01 0.2090 -9.31e-02 -0.187000 6.48e-01 3.60e-01
RAS signaling downstream of NF1 loss-of-function variants 7 5.29e-01 6.41e-01 0.2090 -2.04e-01 0.046200 3.51e-01 8.32e-01
Hyaluronan uptake and degradation 12 3.49e-01 4.80e-01 0.2090 -2.06e-01 0.034800 2.17e-01 8.35e-01
mRNA 3’-end processing 57 2.09e-03 9.76e-03 0.2090 -1.46e-01 0.149000 5.68e-02 5.15e-02
RNA Polymerase II Transcription Termination 66 8.04e-04 4.68e-03 0.2080 -1.41e-01 0.153000 4.73e-02 3.11e-02
Sphingolipid catabolism 11 5.19e-01 6.33e-01 0.2080 -6.29e-02 -0.199000 7.18e-01 2.54e-01
Protein hydroxylation 17 1.63e-01 2.75e-01 0.2080 -1.66e-01 0.126000 2.37e-01 3.69e-01
Gluconeogenesis 19 1.60e-01 2.70e-01 0.2080 -7.02e-02 0.196000 5.96e-01 1.39e-01
Interleukin-12 family signaling 53 7.82e-03 2.82e-02 0.2080 -2.02e-01 0.051200 1.11e-02 5.19e-01
Recognition of DNA damage by PCNA-containing replication complex 30 4.95e-02 1.17e-01 0.2080 -1.89e-01 0.087100 7.36e-02 4.09e-01
Ion transport by P-type ATPases 44 1.07e-01 2.00e-01 0.2080 1.01e-01 0.182000 2.46e-01 3.71e-02
Rab regulation of trafficking 121 2.99e-06 4.27e-05 0.2080 -1.18e-01 0.171000 2.47e-02 1.17e-03
Nucleotide Excision Repair 108 1.03e-05 1.22e-04 0.2080 -1.62e-01 0.130000 3.70e-03 1.93e-02
NrCAM interactions 6 7.13e-01 7.90e-01 0.2080 1.94e-01 0.074300 4.11e-01 7.53e-01
Chromosome Maintenance 103 1.21e-04 9.49e-04 0.2080 -3.87e-02 0.204000 4.97e-01 3.50e-04
Hedgehog ‘on’ state 66 8.73e-04 4.96e-03 0.2070 -1.57e-01 0.136000 2.77e-02 5.60e-02
Leishmania infection 213 2.23e-10 8.28e-09 0.2070 -1.18e-01 0.171000 3.05e-03 1.74e-05
Parasitic Infection Pathways 213 2.23e-10 8.28e-09 0.2070 -1.18e-01 0.171000 3.05e-03 1.74e-05
Vitamin C (ascorbate) metabolism 8 6.75e-01 7.60e-01 0.2070 1.76e-01 0.110000 3.90e-01 5.90e-01
Chaperone Mediated Autophagy 20 2.84e-01 4.14e-01 0.2070 -2.02e-01 -0.047100 1.18e-01 7.15e-01
p75 NTR receptor-mediated signalling 89 2.16e-04 1.51e-03 0.2070 -6.80e-02 0.195000 2.68e-01 1.44e-03
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.22e-01 4.54e-01 0.2070 -2.06e-01 0.016500 1.82e-01 9.15e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 191 1.70e-09 5.21e-08 0.2070 -1.43e-01 0.149000 6.60e-04 3.68e-04
Na+/Cl- dependent neurotransmitter transporters 8 4.65e-01 5.88e-01 0.2070 1.94e-01 -0.070700 3.41e-01 7.29e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 5.00e-03 1.98e-02 0.2070 -7.48e-02 0.193000 3.37e-01 1.35e-02
COPI-mediated anterograde transport 92 6.08e-05 5.48e-04 0.2070 -1.32e-01 0.159000 2.85e-02 8.44e-03
Constitutive Signaling by Overexpressed ERBB2 11 3.11e-01 4.43e-01 0.2070 -1.38e-01 0.154000 4.29e-01 3.77e-01
Centrosome maturation 81 1.41e-03 7.02e-03 0.2060 -1.85e-02 0.206000 7.74e-01 1.38e-03
Recruitment of mitotic centrosome proteins and complexes 81 1.41e-03 7.02e-03 0.2060 -1.85e-02 0.206000 7.74e-01 1.38e-03
TICAM1-dependent activation of IRF3/IRF7 13 5.38e-01 6.47e-01 0.2060 1.71e-01 0.116000 2.87e-01 4.68e-01
Alpha-protein kinase 1 signaling pathway 11 5.80e-01 6.79e-01 0.2060 -1.03e-01 -0.178000 5.54e-01 3.06e-01
Infectious disease 958 6.92e-43 3.33e-40 0.2060 -1.50e-01 0.141000 3.83e-15 1.39e-13
Digestion 5 6.78e-01 7.61e-01 0.2060 2.05e-01 -0.008500 4.26e-01 9.74e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.26e-02 6.51e-02 0.2060 -9.48e-02 0.182000 3.12e-01 5.16e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 5.04e-01 6.22e-01 0.2060 -2.96e-03 0.206000 9.88e-01 2.86e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 4.04e-01 5.31e-01 0.2060 -1.46e-01 -0.145000 2.59e-01 2.62e-01
CLEC7A (Dectin-1) signaling 86 1.14e-03 6.04e-03 0.2060 -2.05e-01 0.012800 1.01e-03 8.37e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 5.59e-02 1.27e-01 0.2050 -2.05e-01 0.017200 3.36e-02 8.58e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 2.11e-01 3.31e-01 0.2050 -2.34e-02 0.204000 8.60e-01 1.24e-01
Membrane Trafficking 574 3.88e-26 5.34e-24 0.2050 -1.59e-01 0.130000 8.00e-11 9.81e-08
Pyrimidine salvage 10 4.15e-01 5.42e-01 0.2050 -2.00e-01 0.045200 2.73e-01 8.05e-01
Toll Like Receptor 4 (TLR4) Cascade 138 4.72e-05 4.42e-04 0.2050 -2.05e-01 -0.007970 3.24e-05 8.72e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 188 1.23e-05 1.42e-04 0.2050 5.03e-02 0.199000 2.34e-01 2.64e-06
CD209 (DC-SIGN) signaling 20 1.76e-01 2.90e-01 0.2050 -4.31e-02 0.200000 7.39e-01 1.21e-01
Cellular responses to mechanical stimuli 82 6.09e-04 3.69e-03 0.2050 -1.96e-01 0.057200 2.10e-03 3.71e-01
Response of endothelial cells to shear stress 82 6.09e-04 3.69e-03 0.2050 -1.96e-01 0.057200 2.10e-03 3.71e-01
Dectin-2 family 19 4.23e-01 5.48e-01 0.2050 -1.32e-01 -0.156000 3.18e-01 2.39e-01
GPVI-mediated activation cascade 32 3.70e-02 9.35e-02 0.2050 -1.23e-01 0.164000 2.29e-01 1.09e-01
Iron uptake and transport 52 3.16e-02 8.28e-02 0.2050 -2.03e-01 -0.027800 1.15e-02 7.29e-01
Vesicle-mediated transport 665 6.39e-30 1.23e-27 0.2040 -1.35e-01 0.154000 2.90e-09 1.41e-11
TP53 Regulates Transcription of DNA Repair Genes 61 2.39e-03 1.09e-02 0.2040 -9.66e-02 0.180000 1.92e-01 1.50e-02
Cellular hexose transport 15 5.10e-01 6.28e-01 0.2040 1.39e-01 0.150000 3.50e-01 3.16e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 1.32e-02 4.30e-02 0.2040 -1.96e-01 0.057300 1.87e-02 4.92e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 3.48e-04 2.30e-03 0.2040 -1.89e-01 0.077200 2.73e-03 2.21e-01
Interleukin-12 signaling 44 2.39e-02 6.75e-02 0.2040 -2.01e-01 0.037300 2.12e-02 6.68e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 1.30e-04 9.96e-04 0.2040 -9.48e-02 0.181000 1.18e-01 2.87e-03
Amplification of signal from the kinetochores 91 1.30e-04 9.96e-04 0.2040 -9.48e-02 0.181000 1.18e-01 2.87e-03
Regulation of TP53 Activity through Phosphorylation 88 1.92e-04 1.39e-03 0.2040 -1.83e-01 0.089700 2.96e-03 1.46e-01
G beta:gamma signalling through PI3Kgamma 22 1.19e-01 2.20e-01 0.2040 -1.84e-01 0.087400 1.36e-01 4.78e-01
Regulation of RAS by GAPs 55 8.42e-03 3.01e-02 0.2030 -1.98e-01 0.047100 1.11e-02 5.46e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 6.10e-01 7.05e-01 0.2030 -2.01e-01 0.030600 3.94e-01 8.97e-01
TGFBR1 KD Mutants in Cancer 6 6.10e-01 7.05e-01 0.2030 -2.01e-01 0.030600 3.94e-01 8.97e-01
STAT5 activation downstream of FLT3 ITD mutants 9 3.99e-01 5.27e-01 0.2030 -1.27e-01 0.158000 5.08e-01 4.12e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 1.65e-02 5.15e-02 0.2030 -2.02e-01 -0.020500 6.41e-03 7.82e-01
mRNA Splicing - Minor Pathway 50 1.48e-02 4.71e-02 0.2030 -4.01e-02 0.199000 6.24e-01 1.51e-02
PI Metabolism 79 3.41e-04 2.26e-03 0.2030 -1.60e-01 0.124000 1.40e-02 5.61e-02
Bacterial Infection Pathways 65 2.12e-03 9.87e-03 0.2030 -1.85e-01 0.083300 1.01e-02 2.45e-01
HDR through Single Strand Annealing (SSA) 37 2.52e-02 7.01e-02 0.2020 -1.10e-01 0.170000 2.46e-01 7.38e-02
Mitochondrial unfolded protein response (UPRmt) 17 3.87e-01 5.16e-01 0.2020 6.29e-02 0.192000 6.54e-01 1.70e-01
RHOA GTPase cycle 138 1.05e-05 1.24e-04 0.2020 -3.75e-02 0.199000 4.47e-01 5.49e-05
SCF(Skp2)-mediated degradation of p27/p21 50 2.16e-02 6.31e-02 0.2020 -2.02e-01 0.013600 1.35e-02 8.68e-01
Regulation of MITF-M-dependent genes involved in pigmentation 38 5.03e-02 1.18e-01 0.2020 -2.12e-02 0.201000 8.21e-01 3.21e-02
Peroxisomal protein import 58 2.27e-02 6.54e-02 0.2020 -2.00e-01 -0.025700 8.31e-03 7.35e-01
Downstream signal transduction 27 6.52e-02 1.41e-01 0.2020 -1.30e-01 0.154000 2.41e-01 1.66e-01
Regulation of innate immune responses to cytosolic DNA 14 4.65e-01 5.88e-01 0.2020 6.57e-02 0.191000 6.70e-01 2.17e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 2.94e-01 4.23e-01 0.2020 -1.95e-01 -0.051200 1.22e-01 6.85e-01
Neurodegenerative Diseases 21 2.94e-01 4.23e-01 0.2020 -1.95e-01 -0.051200 1.22e-01 6.85e-01
Constitutive Signaling by EGFRvIII 14 2.43e-01 3.69e-01 0.2010 -1.35e-01 0.150000 3.82e-01 3.32e-01
Signaling by EGFRvIII in Cancer 14 2.43e-01 3.69e-01 0.2010 -1.35e-01 0.150000 3.82e-01 3.32e-01
Degradation of DVL 43 2.65e-02 7.26e-02 0.2010 -1.97e-01 0.043900 2.57e-02 6.18e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 7.19e-01 7.93e-01 0.2010 1.01e-01 0.174000 6.43e-01 4.25e-01
Serine biosynthesis 8 7.04e-01 7.84e-01 0.2010 -1.30e-01 -0.153000 5.23e-01 4.52e-01
Aspartate and asparagine metabolism 9 5.20e-01 6.34e-01 0.2010 1.48e-03 -0.201000 9.94e-01 2.96e-01
Pyruvate metabolism 44 1.36e-02 4.39e-02 0.2010 -1.71e-01 0.106000 4.99e-02 2.23e-01
Diseases associated with O-glycosylation of proteins 50 1.14e-01 2.12e-01 0.2010 1.33e-01 0.151000 1.03e-01 6.55e-02
IRF3-mediated induction of type I IFN 12 3.05e-01 4.35e-01 0.2010 -1.15e-01 0.165000 4.90e-01 3.23e-01
RHO GTPases activate PKNs 46 1.05e-01 1.98e-01 0.2010 -1.80e-01 -0.089600 3.47e-02 2.93e-01
Signaling by FGFR3 in disease 14 5.15e-01 6.31e-01 0.2010 -1.75e-01 -0.098800 2.57e-01 5.22e-01
Processing of Capped Intronless Pre-mRNA 29 6.16e-02 1.35e-01 0.2010 -1.76e-01 0.097500 1.02e-01 3.64e-01
Disorders of transmembrane transporters 136 1.66e-06 2.45e-05 0.2010 -1.66e-01 0.113000 8.45e-04 2.27e-02
Phospholipase C-mediated cascade: FGFR1 8 5.13e-01 6.30e-01 0.2010 4.24e-02 -0.196000 8.36e-01 3.37e-01
RHOD GTPase cycle 49 7.51e-03 2.72e-02 0.2000 -1.42e-01 0.141000 8.57e-02 8.69e-02
Ub-specific processing proteases 153 2.62e-06 3.79e-05 0.2000 -1.95e-01 0.047200 3.24e-05 3.14e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 51 4.21e-02 1.03e-01 0.2000 3.22e-02 0.197000 6.91e-01 1.47e-02
TICAM1, RIP1-mediated IKK complex recruitment 19 3.32e-01 4.63e-01 0.2000 -1.94e-01 -0.047600 1.43e-01 7.19e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 76 1.22e-02 4.04e-02 0.1990 -1.94e-01 -0.046300 3.46e-03 4.85e-01
Impaired BRCA2 binding to PALB2 24 9.30e-02 1.82e-01 0.1990 -1.42e-01 0.140000 2.29e-01 2.35e-01
rRNA modification in the mitochondrion 8 7.11e-01 7.89e-01 0.1990 1.42e-01 0.140000 4.86e-01 4.94e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 4.03e-01 5.30e-01 0.1990 -1.98e-01 0.018100 2.34e-01 9.14e-01
Ephrin signaling 18 2.55e-01 3.83e-01 0.1990 -1.98e-01 0.018400 1.45e-01 8.93e-01
Late endosomal microautophagy 30 6.18e-02 1.35e-01 0.1990 -8.73e-02 0.179000 4.08e-01 8.98e-02
The phototransduction cascade 27 9.04e-02 1.78e-01 0.1990 7.01e-02 -0.186000 5.29e-01 9.39e-02
Uptake and function of anthrax toxins 11 3.68e-01 4.98e-01 0.1990 -1.83e-01 0.078900 2.94e-01 6.50e-01
Metabolism of amine-derived hormones 10 4.74e-01 5.94e-01 0.1980 1.74e-02 -0.197000 9.24e-01 2.80e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 2.71e-01 4.00e-01 0.1980 -1.94e-01 -0.037600 1.15e-01 7.60e-01
RHOT1 GTPase cycle 5 7.81e-01 8.47e-01 0.1980 -7.83e-02 -0.181000 7.62e-01 4.82e-01
Innate Immune System 970 4.55e-36 1.25e-33 0.1970 -1.85e-01 0.068200 1.33e-22 3.23e-04
Signaling by Insulin receptor 63 2.49e-02 6.95e-02 0.1970 -1.94e-01 -0.039100 7.88e-03 5.91e-01
Signaling by NTRKs 116 3.16e-04 2.13e-03 0.1970 -1.97e-01 0.001480 2.41e-04 9.78e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.86e-02 5.66e-02 0.1970 -1.96e-01 -0.021300 7.12e-03 7.70e-01
Digestion and absorption 7 7.17e-01 7.92e-01 0.1970 1.77e-01 0.085800 4.17e-01 6.94e-01
Phosphorylation of the APC/C 20 2.85e-01 4.14e-01 0.1970 -1.96e-01 -0.022700 1.30e-01 8.60e-01
Intrinsic Pathway for Apoptosis 54 7.33e-03 2.67e-02 0.1970 -1.76e-01 0.088400 2.53e-02 2.61e-01
Glucagon signaling in metabolic regulation 26 8.16e-02 1.65e-01 0.1970 -1.46e-01 0.132000 1.96e-01 2.45e-01
Integrin signaling 22 2.90e-01 4.19e-01 0.1970 -1.91e-01 -0.046900 1.21e-01 7.03e-01
RUNX2 regulates genes involved in cell migration 6 5.67e-01 6.67e-01 0.1970 -1.11e-01 0.163000 6.39e-01 4.90e-01
MicroRNA (miRNA) biogenesis 24 1.02e-01 1.94e-01 0.1970 -1.16e-01 0.159000 3.26e-01 1.77e-01
MyD88-independent TLR4 cascade 108 5.15e-04 3.22e-03 0.1970 -1.97e-01 0.005280 4.15e-04 9.25e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 5.15e-04 3.22e-03 0.1970 -1.97e-01 0.005280 4.15e-04 9.25e-01
RHOBTB2 GTPase cycle 23 1.10e-01 2.05e-01 0.1970 -1.32e-01 0.146000 2.74e-01 2.26e-01
RHOF GTPase cycle 38 4.68e-02 1.12e-01 0.1960 -1.92e-01 0.043600 4.10e-02 6.42e-01
Phospholipase C-mediated cascade; FGFR4 6 6.88e-01 7.69e-01 0.1960 1.95e-01 0.023400 4.08e-01 9.21e-01
RHO GTPases Activate NADPH Oxidases 22 3.91e-01 5.19e-01 0.1960 -1.15e-01 -0.159000 3.50e-01 1.96e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 2.05e-02 6.09e-02 0.1960 -1.96e-01 -0.017600 8.23e-03 8.12e-01
Signaling by FGFR3 32 9.81e-02 1.88e-01 0.1960 -1.96e-01 0.014100 5.52e-02 8.90e-01
VEGFR2 mediated cell proliferation 18 2.27e-01 3.52e-01 0.1960 -1.89e-01 0.052400 1.66e-01 7.00e-01
Non-integrin membrane-ECM interactions 49 7.17e-02 1.49e-01 0.1960 -5.38e-02 -0.188000 5.15e-01 2.27e-02
Nitric oxide stimulates guanylate cyclase 15 5.32e-01 6.44e-01 0.1960 1.18e-01 0.156000 4.28e-01 2.96e-01
Mitochondrial RNA degradation 25 3.56e-01 4.87e-01 0.1950 -1.25e-01 -0.150000 2.78e-01 1.95e-01
Budding and maturation of HIV virion 26 8.84e-02 1.75e-01 0.1950 -1.60e-01 0.112000 1.59e-01 3.21e-01
Impaired BRCA2 binding to RAD51 35 3.99e-02 9.93e-02 0.1950 -1.03e-01 0.165000 2.90e-01 9.02e-02
Metabolism of amino acids and derivatives 305 1.65e-07 3.32e-06 0.1950 -1.85e-01 -0.060300 2.54e-08 7.03e-02
Homology Directed Repair 110 1.99e-04 1.42e-03 0.1950 -3.74e-02 0.191000 4.98e-01 5.30e-04
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 3.63e-02 9.21e-02 0.1950 -1.06e-01 0.163000 2.70e-01 9.01e-02
RHO GTPases activate CIT 18 2.89e-01 4.18e-01 0.1950 -5.79e-03 0.194000 9.66e-01 1.53e-01
Regulation of PTEN gene transcription 59 1.02e-02 3.51e-02 0.1940 -3.89e-02 0.191000 6.05e-01 1.14e-02
FRS-mediated FGFR3 signaling 12 5.40e-01 6.49e-01 0.1940 -1.85e-01 -0.060700 2.68e-01 7.16e-01
Regulation of PLK1 Activity at G2/M Transition 87 1.07e-03 5.76e-03 0.1940 -4.30e-02 0.190000 4.88e-01 2.24e-03
Post-translational protein phosphorylation 67 1.86e-02 5.65e-02 0.1940 -1.92e-01 -0.028000 6.49e-03 6.92e-01
SHC-mediated cascade:FGFR1 13 5.90e-01 6.87e-01 0.1940 -1.29e-01 -0.145000 4.19e-01 3.66e-01
Signaling by FGFR4 32 1.08e-01 2.03e-01 0.1940 -1.94e-01 0.008620 5.75e-02 9.33e-01
Complex IV assembly 45 7.42e-02 1.52e-01 0.1940 -1.91e-01 -0.033700 2.66e-02 6.96e-01
Pyroptosis 25 9.66e-02 1.87e-01 0.1940 -1.34e-01 0.140000 2.46e-01 2.26e-01
DNA Damage/Telomere Stress Induced Senescence 42 2.00e-02 6.02e-02 0.1930 -1.34e-01 0.140000 1.34e-01 1.17e-01
Meiotic recombination 37 6.61e-02 1.42e-01 0.1930 -1.92e-01 0.025300 4.36e-02 7.90e-01
Metabolism of proteins 1775 1.21e-60 2.33e-57 0.1930 -1.81e-01 0.067900 7.40e-37 2.04e-06
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 2.18e-03 1.01e-02 0.1930 -1.41e-01 0.132000 4.77e-02 6.30e-02
Syndecan interactions 25 3.67e-01 4.98e-01 0.1930 -1.41e-01 -0.132000 2.21e-01 2.54e-01
Phospholipid metabolism 183 1.31e-06 1.99e-05 0.1930 -1.91e-01 0.029900 8.50e-06 4.85e-01
Signaling by FGFR2 IIIa TM 18 2.09e-01 3.29e-01 0.1930 -8.41e-02 0.173000 5.37e-01 2.03e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 5.05e-02 1.18e-01 0.1930 -8.97e-02 0.171000 3.65e-01 8.52e-02
Apoptosis 158 1.31e-05 1.49e-04 0.1930 -1.91e-01 0.020400 3.27e-05 6.58e-01
tRNA Aminoacylation 42 3.57e-02 9.08e-02 0.1920 -5.13e-02 0.185000 5.65e-01 3.75e-02
Signaling by NOTCH1 66 3.87e-03 1.63e-02 0.1920 -7.30e-02 0.178000 3.05e-01 1.24e-02
Costimulation by the CD28 family 74 3.21e-03 1.39e-02 0.1920 -4.49e-02 0.187000 5.05e-01 5.41e-03
Cyclin A/B1/B2 associated events during G2/M transition 25 1.89e-01 3.06e-01 0.1920 -3.59e-03 0.192000 9.75e-01 9.66e-02
VEGFA-VEGFR2 Pathway 92 1.01e-03 5.53e-03 0.1920 -1.88e-01 0.036000 1.78e-03 5.50e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.99e-02 1.17e-01 0.1920 -1.66e-01 0.096200 9.39e-02 3.32e-01
Peroxisomal lipid metabolism 27 2.22e-01 3.45e-01 0.1910 -1.88e-01 -0.035800 9.07e-02 7.47e-01
FCERI mediated NF-kB activation 130 1.55e-05 1.70e-04 0.1910 -8.28e-02 0.173000 1.03e-01 6.75e-04
GRB2 events in ERBB2 signaling 11 6.20e-01 7.13e-01 0.1910 -1.68e-01 -0.091200 3.34e-01 6.00e-01
Diseases of DNA repair 51 1.24e-02 4.08e-02 0.1910 -8.60e-02 0.171000 2.88e-01 3.46e-02
Regulation of localization of FOXO transcription factors 12 5.50e-01 6.57e-01 0.1910 -1.82e-01 -0.059800 2.76e-01 7.20e-01
PKR-mediated signaling 67 2.32e-03 1.06e-02 0.1910 -1.45e-01 0.124000 3.97e-02 7.86e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 8.48e-02 1.69e-01 0.1910 -1.85e-01 0.046000 6.94e-02 6.53e-01
UCH proteinases 73 1.35e-03 6.80e-03 0.1910 -1.43e-01 0.127000 3.50e-02 6.07e-02
Sema4D mediated inhibition of cell attachment and migration 7 5.35e-01 6.46e-01 0.1910 -1.55e-01 0.111000 4.77e-01 6.11e-01
HATs acetylate histones 92 2.52e-04 1.76e-03 0.1910 -1.24e-01 0.145000 4.02e-02 1.61e-02
Phenylalanine and tyrosine metabolism 9 6.14e-01 7.08e-01 0.1910 1.86e-01 0.040000 3.33e-01 8.35e-01
Class I MHC mediated antigen processing & presentation 345 2.18e-12 1.11e-10 0.1910 -1.83e-01 0.054900 5.64e-09 7.98e-02
Butyrophilin (BTN) family interactions 10 6.18e-01 7.12e-01 0.1910 1.79e-01 0.065400 3.27e-01 7.20e-01
Diseases associated with the TLR signaling cascade 29 1.09e-01 2.03e-01 0.1900 -1.85e-01 0.045700 8.49e-02 6.70e-01
Diseases of Immune System 29 1.09e-01 2.03e-01 0.1900 -1.85e-01 0.045700 8.49e-02 6.70e-01
Mitochondrial biogenesis 91 2.80e-04 1.93e-03 0.1900 -1.37e-01 0.132000 2.38e-02 2.96e-02
Post-translational protein modification 1245 1.89e-45 1.22e-42 0.1900 -1.63e-01 0.098400 3.87e-22 5.15e-09
Autophagy 142 1.19e-05 1.39e-04 0.1900 -1.80e-01 0.062200 2.18e-04 2.00e-01
Resolution of D-Loop Structures 35 5.80e-02 1.30e-01 0.1900 -6.86e-02 0.177000 4.83e-01 6.99e-02
DNA Replication Pre-Initiation 103 3.42e-04 2.26e-03 0.1900 -1.82e-01 0.052800 1.40e-03 3.54e-01
C-type lectin receptors (CLRs) 118 6.49e-04 3.90e-03 0.1890 -1.89e-01 -0.005420 3.80e-04 9.19e-01
Recycling pathway of L1 40 3.24e-02 8.41e-02 0.1890 -1.65e-01 0.093800 7.17e-02 3.04e-01
MHC class II antigen presentation 113 4.35e-05 4.13e-04 0.1890 -1.33e-01 0.135000 1.49e-02 1.32e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 5.07e-02 1.18e-01 0.1890 -1.52e-02 0.189000 8.62e-01 3.04e-02
FRS-mediated FGFR1 signaling 15 5.55e-01 6.61e-01 0.1890 -1.50e-01 -0.115000 3.14e-01 4.41e-01
Resolution of Sister Chromatid Cohesion 116 4.18e-05 3.99e-04 0.1890 -1.10e-01 0.153000 4.13e-02 4.30e-03
Signaling by Nuclear Receptors 210 1.01e-08 2.82e-07 0.1890 -1.23e-01 0.143000 2.04e-03 3.67e-04
Post-translational modification: synthesis of GPI-anchored proteins 60 6.68e-02 1.44e-01 0.1880 -1.74e-01 -0.072700 2.00e-02 3.30e-01
Degradation of beta-catenin by the destruction complex 72 2.06e-03 9.63e-03 0.1880 -1.56e-01 0.105000 2.24e-02 1.23e-01
Neddylation 216 2.22e-08 5.85e-07 0.1880 -1.70e-01 0.080800 1.74e-05 4.08e-02
Energy dependent regulation of mTOR by LKB1-AMPK 27 9.39e-02 1.83e-01 0.1880 -1.41e-01 0.124000 2.04e-01 2.65e-01
SUMOylation of intracellular receptors 26 1.22e-01 2.22e-01 0.1880 -1.72e-01 0.075600 1.30e-01 5.05e-01
Mitotic Prometaphase 193 1.83e-07 3.56e-06 0.1870 -7.54e-02 0.172000 7.10e-02 3.90e-05
RHOU GTPase cycle 40 5.22e-02 1.21e-01 0.1870 -4.40e-02 0.182000 6.30e-01 4.62e-02
Receptor-type tyrosine-protein phosphatases 11 5.66e-01 6.66e-01 0.1870 -4.12e-02 -0.183000 8.13e-01 2.94e-01
PKA activation in glucagon signalling 14 3.86e-01 5.16e-01 0.1870 -2.11e-02 0.186000 8.91e-01 2.28e-01
Cellular responses to stimuli 778 2.46e-26 3.65e-24 0.1870 -1.76e-01 0.064100 7.28e-17 2.34e-03
SHC-mediated cascade:FGFR3 10 6.60e-01 7.45e-01 0.1870 -1.65e-01 -0.088800 3.67e-01 6.27e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.19e-01 2.19e-01 0.1870 -6.88e-02 0.173000 5.36e-01 1.19e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 1.03e-03 5.59e-03 0.1860 -1.86e-01 -0.003130 6.16e-04 9.54e-01
Nonsense-Mediated Decay (NMD) 113 1.03e-03 5.59e-03 0.1860 -1.86e-01 -0.003130 6.16e-04 9.54e-01
Cellular responses to stress 697 5.97e-24 7.19e-22 0.1860 -1.73e-01 0.069500 6.78e-15 1.76e-03
Fanconi Anemia Pathway 36 4.92e-02 1.16e-01 0.1860 -9.65e-02 0.160000 3.16e-01 9.77e-02
Sensory processing of sound 58 4.53e-02 1.10e-01 0.1860 3.25e-02 0.184000 6.69e-01 1.56e-02
Platelet calcium homeostasis 22 3.25e-01 4.57e-01 0.1860 4.15e-02 0.182000 7.36e-01 1.40e-01
Pregnenolone biosynthesis 10 6.78e-01 7.61e-01 0.1860 1.04e-01 0.154000 5.68e-01 3.99e-01
Regulation of endogenous retroelements 93 4.87e-03 1.94e-02 0.1860 1.60e-02 0.185000 7.89e-01 2.00e-03
Deadenylation-dependent mRNA decay 50 2.13e-02 6.25e-02 0.1860 -1.75e-01 0.062500 3.22e-02 4.44e-01
Macroautophagy 128 1.16e-04 9.23e-04 0.1860 -1.82e-01 0.037500 3.79e-04 4.64e-01
Regulation of TP53 Activity through Methylation 19 2.14e-01 3.34e-01 0.1860 -8.43e-02 0.165000 5.25e-01 2.12e-01
Vitamin B5 (pantothenate) metabolism 20 3.87e-01 5.16e-01 0.1860 5.51e-02 0.177000 6.70e-01 1.70e-01
Platelet activation, signaling and aggregation 221 5.28e-06 6.91e-05 0.1860 -1.84e-01 -0.022600 2.35e-06 5.63e-01
Regulation of TP53 Degradation 35 5.48e-02 1.26e-01 0.1850 -1.58e-01 0.097100 1.06e-01 3.20e-01
HCMV Infection 106 1.72e-04 1.26e-03 0.1850 -9.10e-02 0.161000 1.06e-01 4.07e-03
Homologous DNA Pairing and Strand Exchange 43 2.56e-02 7.09e-02 0.1850 -1.33e-01 0.129000 1.32e-01 1.44e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 9.54e-03 3.32e-02 0.1850 -1.68e-01 0.076100 2.53e-02 3.12e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 2.62e-01 3.90e-01 0.1850 1.09e-01 -0.149000 4.50e-01 3.02e-01
Downregulation of TGF-beta receptor signaling 26 1.63e-01 2.75e-01 0.1840 -1.81e-01 0.036100 1.10e-01 7.50e-01
GPER1 signaling 38 6.14e-02 1.35e-01 0.1840 -1.77e-01 0.051300 5.88e-02 5.84e-01
Golgi-to-ER retrograde transport 123 3.54e-05 3.50e-04 0.1840 -1.11e-01 0.147000 3.41e-02 4.73e-03
Cytosolic sensors of pathogen-associated DNA 63 6.82e-03 2.54e-02 0.1840 -7.97e-02 0.166000 2.74e-01 2.25e-02
Extra-nuclear estrogen signaling 65 3.19e-02 8.31e-02 0.1840 -1.82e-01 -0.028700 1.11e-02 6.89e-01
Signaling by the B Cell Receptor (BCR) 151 2.27e-05 2.38e-04 0.1840 -4.20e-02 0.179000 3.73e-01 1.41e-04
Physiological factors 9 4.67e-01 5.89e-01 0.1840 1.34e-01 -0.127000 4.88e-01 5.10e-01
PCP/CE pathway 75 2.17e-03 1.01e-02 0.1840 -1.57e-01 0.096900 1.90e-02 1.47e-01
SARS-CoV-1 Infection 137 1.77e-05 1.92e-04 0.1840 -1.63e-01 0.085600 9.78e-04 8.37e-02
Negative regulation of FGFR2 signaling 24 3.19e-01 4.51e-01 0.1840 -1.77e-01 -0.050900 1.33e-01 6.66e-01
Glutathione conjugation 27 3.56e-01 4.87e-01 0.1840 -1.01e-01 -0.154000 3.62e-01 1.67e-01
Defective GALNT12 causes CRCS1 9 4.69e-01 5.91e-01 0.1840 1.27e-01 -0.133000 5.09e-01 4.90e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 5.23e-01 6.37e-01 0.1840 1.01e-01 0.153000 4.69e-01 2.74e-01
Aerobic respiration and respiratory electron transport 245 9.94e-08 2.13e-06 0.1830 -1.82e-01 0.025200 9.58e-07 4.97e-01
Fc epsilon receptor (FCERI) signaling 180 4.10e-07 7.45e-06 0.1830 -1.05e-01 0.151000 1.55e-02 4.90e-04
Regulation of TP53 Expression and Degradation 36 6.35e-02 1.38e-01 0.1830 -1.70e-01 0.069500 7.81e-02 4.70e-01
Biosynthesis of DHA-derived SPMs 14 3.18e-01 4.51e-01 0.1830 1.53e-01 -0.101000 3.21e-01 5.14e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 6.89e-01 7.70e-01 0.1830 7.85e-02 0.165000 6.83e-01 3.90e-01
G beta:gamma signalling through BTK 15 3.46e-01 4.79e-01 0.1830 -1.78e-01 0.043600 2.33e-01 7.70e-01
Chaperonin-mediated protein folding 77 2.42e-03 1.10e-02 0.1830 -1.64e-01 0.081100 1.29e-02 2.19e-01
Protein folding 83 1.44e-03 7.09e-03 0.1830 -1.62e-01 0.085200 1.08e-02 1.80e-01
Signaling by TGFB family members 137 1.29e-05 1.48e-04 0.1830 -1.44e-01 0.113000 3.73e-03 2.21e-02
Proton-coupled monocarboxylate transport 6 6.39e-01 7.29e-01 0.1830 -1.72e-01 0.062100 4.66e-01 7.92e-01
Condensation of Prophase Chromosomes 27 1.79e-01 2.94e-01 0.1830 -1.82e-01 0.017200 1.02e-01 8.77e-01
Metal ion SLC transporters 19 2.22e-01 3.45e-01 0.1820 -1.60e-01 0.088400 2.28e-01 5.05e-01
Signaling by VEGF 99 1.10e-03 5.88e-03 0.1820 -1.78e-01 0.038900 2.19e-03 5.03e-01
G2/M Checkpoints 126 3.23e-05 3.24e-04 0.1820 -1.28e-01 0.129000 1.29e-02 1.24e-02
Cell Cycle 611 2.91e-20 2.81e-18 0.1820 -6.98e-02 0.168000 3.22e-03 1.33e-12
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 2.59e-02 7.09e-02 0.1820 -1.81e-01 -0.005820 1.20e-02 9.36e-01
RNA polymerase II transcribes snRNA genes 71 3.44e-03 1.48e-02 0.1810 -1.51e-01 0.101000 2.83e-02 1.41e-01
VEGFR2 mediated vascular permeability 25 1.31e-01 2.35e-01 0.1810 -1.39e-01 0.116000 2.30e-01 3.14e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.33e-01 2.36e-01 0.1810 -1.10e-01 0.144000 3.41e-01 2.13e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.33e-01 2.36e-01 0.1810 -1.10e-01 0.144000 3.41e-01 2.13e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.33e-01 2.36e-01 0.1810 -1.10e-01 0.144000 3.41e-01 2.13e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.33e-01 2.36e-01 0.1810 -1.10e-01 0.144000 3.41e-01 2.13e-01
Cell Cycle, Mitotic 488 4.47e-16 3.45e-14 0.1810 -6.52e-02 0.169000 1.37e-02 1.70e-10
Mitotic Anaphase 211 7.16e-08 1.60e-06 0.1810 -1.55e-01 0.093200 1.06e-04 1.97e-02
Metabolism of cofactors 25 2.83e-01 4.14e-01 0.1810 -1.78e-01 -0.030200 1.23e-01 7.94e-01
RNA Polymerase I Transcription Initiation 47 2.59e-02 7.09e-02 0.1800 -8.92e-02 0.157000 2.90e-01 6.29e-02
Metabolism of nucleotides 85 1.69e-03 8.16e-03 0.1800 -1.64e-01 0.074100 8.75e-03 2.38e-01
Signaling by EGFR in Cancer 22 2.05e-01 3.24e-01 0.1800 -1.71e-01 0.058000 1.66e-01 6.37e-01
Regulation of APC/C activators between G1/S and early anaphase 68 9.37e-03 3.28e-02 0.1800 -1.75e-01 0.044400 1.28e-02 5.27e-01
Factors involved in megakaryocyte development and platelet production 129 4.60e-03 1.85e-02 0.1800 6.67e-02 0.167000 1.91e-01 1.03e-03
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 6.82e-02 1.44e-01 0.1800 -1.76e-01 -0.038800 2.29e-02 6.16e-01
SHC-related events triggered by IGF1R 7 6.15e-01 7.09e-01 0.1800 -4.71e-02 0.174000 8.29e-01 4.26e-01
tRNA modification in the mitochondrion 9 7.15e-01 7.91e-01 0.1800 -1.54e-01 -0.093000 4.24e-01 6.29e-01
Prostacyclin signalling through prostacyclin receptor 16 3.15e-01 4.47e-01 0.1800 -1.69e-01 0.061300 2.42e-01 6.71e-01
Programmed Cell Death 187 7.34e-06 9.31e-05 0.1800 -1.78e-01 0.024700 2.73e-05 5.60e-01
Defective B4GALT7 causes EDS, progeroid type 12 3.81e-01 5.11e-01 0.1800 -1.28e-01 0.126000 4.43e-01 4.49e-01
G1/S Transition 120 9.50e-05 7.86e-04 0.1790 -9.44e-02 0.152000 7.42e-02 3.98e-03
ADORA2B mediated anti-inflammatory cytokines production 36 8.65e-02 1.72e-01 0.1790 -1.73e-01 0.044400 7.17e-02 6.44e-01
Mitotic Metaphase and Anaphase 212 8.45e-08 1.85e-06 0.1790 -1.51e-01 0.095700 1.50e-04 1.63e-02
FLT3 signaling by CBL mutants 7 6.47e-01 7.36e-01 0.1790 -1.77e-01 0.020800 4.16e-01 9.24e-01
Methionine salvage pathway 6 8.02e-01 8.59e-01 0.1790 -1.53e-01 -0.092700 5.18e-01 6.94e-01
Meiotic synapsis 43 4.39e-02 1.06e-01 0.1780 -1.64e-01 0.069100 6.21e-02 4.33e-01
Purine salvage 12 4.75e-01 5.95e-01 0.1780 -2.13e-02 0.177000 8.99e-01 2.88e-01
Selective autophagy 77 2.86e-02 7.69e-02 0.1780 -1.73e-01 -0.040900 8.65e-03 5.35e-01
Disease 1623 2.34e-52 2.25e-49 0.1780 -1.31e-01 0.120000 1.17e-18 7.79e-16
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.57e-01 2.67e-01 0.1780 -7.81e-02 0.160000 4.99e-01 1.67e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 3.52e-03 1.51e-02 0.1770 -2.76e-02 0.175000 6.51e-01 4.04e-03
Meiosis 67 6.14e-03 2.35e-02 0.1770 -1.51e-01 0.093900 3.31e-02 1.84e-01
Uptake and function of diphtheria toxin 6 8.12e-01 8.66e-01 0.1770 -1.42e-01 -0.106000 5.46e-01 6.53e-01
Myogenesis 20 2.48e-01 3.75e-01 0.1770 -1.68e-01 0.057600 1.94e-01 6.56e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.52e-01 2.61e-01 0.1770 -7.20e-02 0.162000 5.25e-01 1.53e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 4.12e-02 1.02e-01 0.1770 -1.30e-01 0.120000 1.51e-01 1.82e-01
Diseases of DNA Double-Strand Break Repair 41 4.12e-02 1.02e-01 0.1770 -1.30e-01 0.120000 1.51e-01 1.82e-01
G alpha (12/13) signalling events 68 3.48e-02 8.92e-02 0.1770 2.45e-02 0.175000 7.27e-01 1.26e-02
Transcriptional Regulation by TP53 346 3.30e-12 1.63e-10 0.1770 -1.17e-01 0.133000 1.96e-04 2.22e-05
Formation of definitive endoderm 9 7.09e-01 7.87e-01 0.1770 -1.59e-01 -0.077300 4.09e-01 6.88e-01
Metabolism of steroid hormones 21 4.05e-01 5.31e-01 0.1770 -5.19e-02 -0.169000 6.81e-01 1.81e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 4.79e-02 1.14e-01 0.1770 -1.46e-01 0.099000 1.10e-01 2.79e-01
rRNA modification in the nucleus and cytosol 60 1.14e-02 3.85e-02 0.1760 -1.52e-01 0.088800 4.10e-02 2.34e-01
Assembly of the pre-replicative complex 87 6.61e-03 2.49e-02 0.1760 -1.76e-01 0.010100 4.55e-03 8.70e-01
M Phase 346 3.51e-12 1.69e-10 0.1760 -1.24e-01 0.125000 7.60e-05 6.15e-05
G-protein mediated events 44 3.60e-02 9.16e-02 0.1760 -9.85e-02 0.146000 2.58e-01 9.40e-02
G2/M DNA damage checkpoint 66 6.47e-03 2.45e-02 0.1760 -1.37e-01 0.110000 5.34e-02 1.23e-01
Azathioprine ADME 20 2.44e-01 3.69e-01 0.1760 -1.62e-01 0.067600 2.09e-01 6.01e-01
Diseases of signal transduction by growth factor receptors and second messengers 401 9.07e-14 5.46e-12 0.1760 -1.39e-01 0.108000 1.81e-06 2.20e-04
KEAP1-NFE2L2 pathway 107 5.63e-04 3.48e-03 0.1750 -1.62e-01 0.066700 3.73e-03 2.33e-01
Synthesis of PIPs at the ER membrane 5 7.06e-01 7.85e-01 0.1750 -6.38e-02 0.163000 8.05e-01 5.27e-01
Signaling by ERBB4 45 1.52e-01 2.60e-01 0.1750 -1.67e-01 -0.053500 5.30e-02 5.35e-01
Cell Cycle Checkpoints 246 8.71e-09 2.47e-07 0.1750 -1.30e-01 0.118000 4.66e-04 1.48e-03
Cleavage of the damaged purine 22 1.92e-01 3.08e-01 0.1750 -1.42e-01 0.102000 2.48e-01 4.08e-01
Depurination 22 1.92e-01 3.08e-01 0.1750 -1.42e-01 0.102000 2.48e-01 4.08e-01
Recognition and association of DNA glycosylase with site containing an affected purine 22 1.92e-01 3.08e-01 0.1750 -1.42e-01 0.102000 2.48e-01 4.08e-01
RHO GTPases Activate Formins 128 8.92e-05 7.44e-04 0.1750 -8.73e-02 0.151000 8.82e-02 3.08e-03
DCC mediated attractive signaling 13 4.24e-01 5.48e-01 0.1750 -1.68e-01 0.048700 2.95e-01 7.61e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 3.81e-01 5.11e-01 0.1750 -6.30e-02 0.163000 6.83e-01 2.91e-01
Glycogen metabolism 22 2.67e-01 3.96e-01 0.1740 -1.73e-01 0.023600 1.60e-01 8.48e-01
Sensory processing of sound by inner hair cells of the cochlea 54 9.12e-02 1.79e-01 0.1740 4.05e-02 0.170000 6.07e-01 3.11e-02
RHO GTPases activate KTN1 11 6.10e-01 7.05e-01 0.1740 3.81e-02 0.170000 8.27e-01 3.29e-01
Toll Like Receptor 3 (TLR3) Cascade 104 2.88e-03 1.27e-02 0.1740 -1.74e-01 0.010100 2.20e-03 8.58e-01
Processing of DNA double-strand break ends 69 7.02e-03 2.59e-02 0.1740 -8.52e-02 0.151000 2.21e-01 2.97e-02
TNFR1-induced proapoptotic signaling 24 4.59e-01 5.83e-01 0.1740 1.30e-01 0.116000 2.72e-01 3.27e-01
SARS-CoV-1-host interactions 94 2.31e-03 1.06e-02 0.1730 -1.66e-01 0.047900 5.27e-03 4.22e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.38e-01 2.44e-01 0.1730 -1.41e-01 0.100000 2.05e-01 3.67e-01
Mitotic Spindle Checkpoint 108 3.34e-04 2.23e-03 0.1730 -1.15e-01 0.129000 3.81e-02 2.07e-02
Mitotic G1 phase and G1/S transition 138 5.68e-05 5.26e-04 0.1730 -8.38e-02 0.151000 8.91e-02 2.17e-03
Deubiquitination 225 1.05e-07 2.22e-06 0.1730 -1.47e-01 0.090600 1.44e-04 1.92e-02
Metabolism of RNA 717 9.43e-23 1.01e-20 0.1730 -1.42e-01 0.098800 1.05e-10 6.63e-06
NF-kB is activated and signals survival 12 4.73e-01 5.94e-01 0.1720 -1.68e-01 0.039100 3.14e-01 8.15e-01
Interleukin-1 processing 8 7.16e-01 7.92e-01 0.1720 4.75e-02 0.166000 8.16e-01 4.17e-01
Signaling by FGFR in disease 52 2.25e-02 6.50e-02 0.1720 -1.38e-01 0.103000 8.45e-02 2.00e-01
Ion homeostasis 42 1.27e-01 2.30e-01 0.1720 1.51e-02 0.171000 8.66e-01 5.45e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 2.77e-01 4.07e-01 0.1720 -1.45e-01 0.091500 2.86e-01 5.02e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 2.77e-01 4.07e-01 0.1720 -1.45e-01 0.091500 2.86e-01 5.02e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 4.93e-01 6.12e-01 0.1710 -1.52e-01 -0.078900 2.38e-01 5.42e-01
Oncogene Induced Senescence 33 1.63e-01 2.75e-01 0.1710 -1.71e-01 0.010700 8.89e-02 9.15e-01
RHOG GTPase cycle 70 6.15e-03 2.35e-02 0.1710 -1.16e-01 0.126000 9.42e-02 6.80e-02
Metabolism of carbohydrates 241 2.96e-08 7.52e-07 0.1710 -1.30e-01 0.111000 5.21e-04 2.89e-03
Regulation of pyruvate metabolism 32 9.77e-02 1.88e-01 0.1710 -1.27e-01 0.114000 2.13e-01 2.63e-01
Ubiquinol biosynthesis 13 4.80e-01 5.99e-01 0.1710 -1.70e-01 0.018600 2.89e-01 9.08e-01
Specification of primordial germ cells 6 7.53e-01 8.23e-01 0.1700 -1.88e-02 -0.169000 9.36e-01 4.72e-01
Opioid Signalling 75 4.95e-03 1.96e-02 0.1700 -1.39e-01 0.098700 3.80e-02 1.39e-01
Signaling by FGFR1 42 1.78e-01 2.94e-01 0.1700 -1.64e-01 -0.044700 6.57e-02 6.16e-01
Signaling by TGF-beta Receptor Complex 90 1.61e-03 7.80e-03 0.1700 -1.29e-01 0.110000 3.42e-02 7.00e-02
Signaling by MET 68 4.65e-02 1.11e-01 0.1700 -1.68e-01 -0.025800 1.67e-02 7.13e-01
Dual Incision in GG-NER 41 7.19e-02 1.50e-01 0.1700 -1.60e-01 0.056900 7.63e-02 5.28e-01
Cellular response to chemical stress 179 4.95e-06 6.62e-05 0.1700 -1.48e-01 0.083200 6.43e-04 5.50e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 4.58e-01 5.82e-01 0.1700 5.33e-02 0.161000 6.80e-01 2.13e-01
Trafficking of AMPA receptors 20 4.58e-01 5.82e-01 0.1700 5.33e-02 0.161000 6.80e-01 2.13e-01
DAP12 interactions 39 8.77e-02 1.74e-01 0.1690 -4.92e-02 0.162000 5.95e-01 7.98e-02
Sphingolipid de novo biosynthesis 35 1.49e-01 2.58e-01 0.1690 -1.69e-01 0.013700 8.40e-02 8.89e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 4.35e-01 5.60e-01 0.1690 -1.43e-01 0.091000 3.92e-01 5.85e-01
Defective pyroptosis 27 2.00e-01 3.18e-01 0.1690 -1.65e-01 0.036900 1.38e-01 7.40e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 1.44e-03 7.09e-03 0.1690 -5.47e-02 0.160000 3.35e-01 4.88e-03
CDC42 GTPase cycle 140 1.71e-04 1.26e-03 0.1690 -5.04e-02 0.161000 3.03e-01 9.99e-04
Transcriptional Regulation by MECP2 49 4.36e-02 1.06e-01 0.1690 -5.93e-02 0.158000 4.72e-01 5.57e-02
TRAF6 mediated NF-kB activation 23 2.04e-01 3.22e-01 0.1680 -9.34e-02 0.140000 4.38e-01 2.44e-01
Translesion synthesis by POLI 17 3.76e-01 5.06e-01 0.1680 -1.65e-01 0.030700 2.38e-01 8.27e-01
Glutamate and glutamine metabolism 12 6.44e-01 7.34e-01 0.1680 -1.56e-01 -0.061700 3.48e-01 7.11e-01
Somitogenesis 41 6.73e-02 1.44e-01 0.1680 -1.52e-01 0.072500 9.31e-02 4.22e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 5.55e-01 6.61e-01 0.1680 -1.01e-01 -0.134000 4.46e-01 3.11e-01
ECM proteoglycans 47 1.51e-01 2.59e-01 0.1680 -4.31e-02 -0.162000 6.09e-01 5.42e-02
Signaling by FLT3 ITD and TKD mutants 15 3.61e-01 4.92e-01 0.1680 -1.43e-01 0.087100 3.36e-01 5.59e-01
Nonhomologous End-Joining (NHEJ) 40 7.96e-02 1.62e-01 0.1670 -1.56e-01 0.060900 8.81e-02 5.05e-01
rRNA processing in the nucleus and cytosol 189 6.75e-05 5.97e-04 0.1670 -1.67e-01 0.005830 7.42e-05 8.90e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.05e-01 5.31e-01 0.1670 -1.14e-01 0.122000 4.75e-01 4.47e-01
Regulation of NF-kappa B signaling 18 3.24e-01 4.57e-01 0.1670 -1.56e-01 0.058500 2.51e-01 6.67e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 8.42e-01 8.91e-01 0.1670 1.51e-01 0.070800 5.59e-01 7.84e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 2.57e-02 7.09e-02 0.1670 1.31e-02 0.166000 8.40e-01 1.06e-02
SUMOylation of transcription factors 16 3.33e-01 4.65e-01 0.1670 -1.02e-01 0.132000 4.79e-01 3.61e-01
RNA Polymerase III Chain Elongation 18 3.41e-01 4.74e-01 0.1670 -1.60e-01 0.045400 2.39e-01 7.39e-01
Beta-catenin independent WNT signaling 126 1.90e-04 1.38e-03 0.1670 -1.33e-01 0.100000 9.81e-03 5.26e-02
G alpha (s) signalling events 96 5.67e-03 2.21e-02 0.1670 -1.99e-02 0.165000 7.36e-01 5.11e-03
Signaling by NTRK2 (TRKB) 20 2.56e-01 3.84e-01 0.1660 -1.34e-01 0.098600 2.99e-01 4.45e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 3.57e-01 4.88e-01 0.1660 -1.26e-01 0.108000 3.97e-01 4.68e-01
TCF dependent signaling in response to WNT 152 1.27e-04 9.86e-04 0.1660 -4.52e-02 0.160000 3.36e-01 6.72e-04
Separation of Sister Chromatids 168 1.85e-05 1.98e-04 0.1660 -1.46e-01 0.079000 1.12e-03 7.73e-02
Metalloprotease DUBs 20 5.38e-01 6.48e-01 0.1660 -1.38e-01 -0.091200 2.84e-01 4.80e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.64e-01 2.76e-01 0.1660 -1.48e-01 0.074800 1.76e-01 4.93e-01
Signaling by EGFR 47 5.99e-02 1.33e-01 0.1650 -1.58e-01 0.050000 6.14e-02 5.53e-01
Signaling by WNT in cancer 30 1.30e-01 2.34e-01 0.1650 -1.20e-01 0.114000 2.55e-01 2.82e-01
Defects in vitamin and cofactor metabolism 21 2.43e-01 3.68e-01 0.1650 -1.06e-01 0.126000 4.01e-01 3.16e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 1.79e-01 2.94e-01 0.1650 -1.65e-01 -0.002300 8.72e-02 9.81e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 4.80e-01 5.98e-01 0.1650 -1.78e-02 0.164000 9.08e-01 2.89e-01
HDR through Homologous Recombination (HRR) 68 1.11e-02 3.76e-02 0.1640 -9.66e-02 0.133000 1.68e-01 5.78e-02
Nuclear Receptor transcription pathway 38 9.75e-02 1.88e-01 0.1640 -6.12e-02 0.152000 5.14e-01 1.04e-01
Death Receptor Signaling 145 1.39e-04 1.05e-03 0.1640 -6.31e-02 0.152000 1.90e-01 1.62e-03
EML4 and NUDC in mitotic spindle formation 107 1.19e-03 6.12e-03 0.1640 -7.43e-02 0.146000 1.84e-01 9.06e-03
Signaling by ERBB2 ECD mutants 15 3.85e-01 5.15e-01 0.1640 -7.73e-02 0.144000 6.04e-01 3.33e-01
Oxidative Stress Induced Senescence 77 1.95e-02 5.89e-02 0.1630 -1.62e-01 0.016800 1.39e-02 7.99e-01
Downstream TCR signaling 89 4.68e-03 1.88e-02 0.1630 -1.50e-01 0.062300 1.42e-02 3.10e-01
Recruitment of NuMA to mitotic centrosomes 88 8.89e-03 3.15e-02 0.1630 -2.98e-02 0.160000 6.29e-01 9.56e-03
Paracetamol ADME 19 3.14e-01 4.46e-01 0.1620 -6.74e-02 0.148000 6.11e-01 2.65e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.27e-04 1.59e-03 0.1620 -1.62e-01 0.001770 1.84e-04 9.67e-01
PTEN Regulation 127 2.60e-04 1.80e-03 0.1620 -1.21e-01 0.108000 1.87e-02 3.55e-02
Ketone body metabolism 8 5.93e-01 6.90e-01 0.1620 -1.16e-01 0.113000 5.68e-01 5.81e-01
Synthesis of substrates in N-glycan biosythesis 59 2.21e-02 6.40e-02 0.1620 -1.00e-01 0.127000 1.82e-01 9.19e-02
Epigenetic regulation of gene expression 264 2.57e-07 4.76e-06 0.1620 -5.30e-02 0.153000 1.38e-01 1.92e-05
APC/C-mediated degradation of cell cycle proteins 75 2.09e-02 6.17e-02 0.1620 -1.60e-01 0.022500 1.65e-02 7.37e-01
Regulation of mitotic cell cycle 75 2.09e-02 6.17e-02 0.1620 -1.60e-01 0.022500 1.65e-02 7.37e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 6.50e-01 7.38e-01 0.1620 -7.32e-02 0.144000 7.37e-01 5.09e-01
Interleukin-18 signaling 6 6.88e-01 7.69e-01 0.1620 8.01e-02 -0.140000 7.34e-01 5.52e-01
Signaling by NOTCH 173 1.50e-05 1.66e-04 0.1610 -1.03e-01 0.125000 1.97e-02 4.69e-03
Anchoring of the basal body to the plasma membrane 97 4.04e-03 1.69e-02 0.1610 -4.93e-02 0.153000 4.01e-01 9.01e-03
AKT phosphorylates targets in the cytosol 14 4.64e-01 5.87e-01 0.1610 -3.92e-02 0.156000 8.00e-01 3.12e-01
Orc1 removal from chromatin 58 2.72e-02 7.38e-02 0.1610 -1.39e-01 0.081600 6.75e-02 2.83e-01
Respiratory electron transport 149 9.44e-04 5.23e-03 0.1610 -1.61e-01 0.004100 7.04e-04 9.31e-01
E2F mediated regulation of DNA replication 22 2.44e-01 3.70e-01 0.1610 -1.24e-01 0.102000 3.13e-01 4.08e-01
DAG and IP3 signaling 34 1.98e-01 3.16e-01 0.1610 -7.37e-03 0.161000 9.41e-01 1.05e-01
Signaling by WNT 240 3.18e-07 5.83e-06 0.1610 -9.04e-02 0.133000 1.59e-02 3.98e-04
Signaling by MAPK mutants 6 8.41e-01 8.91e-01 0.1600 -9.13e-02 -0.132000 6.99e-01 5.76e-01
HCMV Early Events 84 6.25e-03 2.38e-02 0.1600 -7.27e-02 0.143000 2.50e-01 2.34e-02
Pre-NOTCH Expression and Processing 63 2.03e-02 6.06e-02 0.1600 -8.30e-02 0.137000 2.55e-01 5.96e-02
Interleukin-7 signaling 21 5.50e-01 6.57e-01 0.1600 1.30e-01 0.093800 3.02e-01 4.57e-01
Cleavage of the damaged pyrimidine 27 1.90e-01 3.06e-01 0.1600 -1.38e-01 0.080800 2.14e-01 4.67e-01
Depyrimidination 27 1.90e-01 3.06e-01 0.1600 -1.38e-01 0.080800 2.14e-01 4.67e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 1.90e-01 3.06e-01 0.1600 -1.38e-01 0.080800 2.14e-01 4.67e-01
Signaling by PDGFRA extracellular domain mutants 12 4.66e-01 5.88e-01 0.1600 -1.20e-01 0.105000 4.70e-01 5.27e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 4.66e-01 5.88e-01 0.1600 -1.20e-01 0.105000 4.70e-01 5.27e-01
Organelle biogenesis and maintenance 278 2.65e-08 6.80e-07 0.1600 -1.18e-01 0.108000 7.08e-04 2.01e-03
EGFR Transactivation by Gastrin 7 8.24e-01 8.78e-01 0.1600 -1.01e-01 -0.123000 6.43e-01 5.72e-01
Signaling by ERBB2 in Cancer 21 3.72e-01 5.03e-01 0.1590 -1.59e-01 0.007710 2.06e-01 9.51e-01
Switching of origins to a post-replicative state 79 1.10e-02 3.74e-02 0.1590 -1.49e-01 0.057000 2.22e-02 3.81e-01
Signaling by Hedgehog 121 6.39e-04 3.85e-03 0.1590 -1.37e-01 0.081600 9.31e-03 1.21e-01
Gene expression (Transcription) 1404 1.03e-35 2.47e-33 0.1590 -8.17e-02 0.137000 2.89e-07 8.64e-18
PKA-mediated phosphorylation of CREB 17 3.49e-01 4.81e-01 0.1590 -8.92e-02 0.132000 5.24e-01 3.46e-01
Induction of Cell-Cell Fusion 8 7.23e-01 7.96e-01 0.1590 -1.58e-01 -0.020100 4.40e-01 9.22e-01
Nuclear events mediated by NFE2L2 82 1.04e-02 3.57e-02 0.1590 -1.51e-01 0.050400 1.82e-02 4.31e-01
B-WICH complex positively regulates rRNA expression 45 1.70e-01 2.83e-01 0.1590 -1.57e-01 -0.024900 6.87e-02 7.72e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 6.83e-01 7.65e-01 0.1590 -1.51e-01 -0.048000 3.85e-01 7.83e-01
RUNX3 Regulates Immune Response and Cell Migration 5 8.68e-01 9.06e-01 0.1590 -9.00e-02 -0.131000 7.27e-01 6.12e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 4.23e-01 5.48e-01 0.1580 1.53e-01 -0.041600 2.90e-01 7.74e-01
Fertilization 13 7.01e-01 7.81e-01 0.1580 1.24e-01 0.099000 4.40e-01 5.37e-01
Transferrin endocytosis and recycling 26 3.31e-01 4.62e-01 0.1580 -1.58e-01 -0.009560 1.63e-01 9.33e-01
ESR-mediated signaling 157 1.10e-04 8.75e-04 0.1580 -1.43e-01 0.067400 1.93e-03 1.45e-01
TGF-beta receptor signaling activates SMADs 45 6.97e-02 1.47e-01 0.1580 -1.40e-01 0.073600 1.04e-01 3.93e-01
Downstream signaling of activated FGFR3 17 4.30e-01 5.55e-01 0.1580 -1.57e-01 0.022500 2.64e-01 8.72e-01
EGFR downregulation 26 3.42e-01 4.75e-01 0.1580 -1.57e-01 -0.014700 1.65e-01 8.97e-01
GP1b-IX-V activation signalling 11 5.16e-01 6.31e-01 0.1580 8.15e-02 -0.135000 6.40e-01 4.37e-01
Inflammasomes 21 3.79e-01 5.09e-01 0.1580 -1.58e-01 0.007900 2.11e-01 9.50e-01
Nucleotide salvage 21 2.84e-01 4.14e-01 0.1580 -8.02e-02 0.136000 5.25e-01 2.81e-01
Interferon gamma signaling 90 6.37e-03 2.42e-02 0.1580 -5.80e-02 0.147000 3.42e-01 1.62e-02
Class B/2 (Secretin family receptors) 57 2.05e-01 3.24e-01 0.1580 8.90e-02 0.130000 2.45e-01 8.92e-02
cGMP effects 12 7.07e-01 7.86e-01 0.1580 7.92e-02 0.136000 6.35e-01 4.14e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 7.34e-01 8.06e-01 0.1570 -1.06e-01 0.116000 6.81e-01 6.52e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 7.34e-01 8.06e-01 0.1570 -1.06e-01 0.116000 6.81e-01 6.52e-01
Cytosolic tRNA aminoacylation 24 2.28e-01 3.52e-01 0.1570 -1.12e-01 0.111000 3.43e-01 3.48e-01
S Phase 150 1.25e-04 9.77e-04 0.1570 -9.05e-02 0.128000 5.58e-02 6.78e-03
E2F-enabled inhibition of pre-replication complex formation 9 5.93e-01 6.90e-01 0.1570 -1.38e-01 0.073400 4.72e-01 7.03e-01
Signaling by NTRK3 (TRKC) 15 6.32e-01 7.25e-01 0.1560 6.40e-02 0.143000 6.68e-01 3.39e-01
Cellular Senescence 143 2.86e-04 1.94e-03 0.1560 -1.38e-01 0.071800 4.29e-03 1.38e-01
Nuclear signaling by ERBB4 24 2.85e-01 4.14e-01 0.1550 -1.48e-01 0.045800 2.10e-01 6.98e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 1.15e-01 2.12e-01 0.1550 -1.47e-01 0.049000 1.04e-01 5.87e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 5.27e-02 1.22e-01 0.1550 -2.64e-02 0.152000 7.22e-01 3.95e-02
PLC beta mediated events 40 1.06e-01 2.00e-01 0.1550 -6.87e-02 0.138000 4.52e-01 1.30e-01
rRNA processing 213 1.29e-04 9.93e-04 0.1540 -1.54e-01 -0.000270 1.02e-04 9.95e-01
Hyaluronan metabolism 15 4.49e-01 5.73e-01 0.1540 -5.35e-02 0.145000 7.20e-01 3.32e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 6.05e-02 1.34e-01 0.1540 -7.97e-02 0.132000 3.34e-01 1.10e-01
Termination of translesion DNA synthesis 32 1.63e-01 2.75e-01 0.1540 -7.57e-02 0.134000 4.59e-01 1.88e-01
Translesion synthesis by POLK 17 4.11e-01 5.37e-01 0.1540 -1.46e-01 0.048600 2.97e-01 7.28e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.70e-01 3.99e-01 0.1540 -4.97e-02 0.146000 6.67e-01 2.08e-01
RNA Polymerase II Transcription 1197 1.53e-28 2.69e-26 0.1540 -7.50e-02 0.134000 1.26e-05 5.00e-15
Ovarian tumor domain proteases 37 1.20e-01 2.20e-01 0.1540 -8.53e-02 0.128000 3.69e-01 1.79e-01
Antigen processing: Ubiquitination & Proteasome degradation 276 2.53e-07 4.73e-06 0.1530 -1.36e-01 0.071100 1.01e-04 4.20e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 2.00e-01 3.18e-01 0.1530 -5.91e-02 0.141000 5.75e-01 1.80e-01
Cell-extracellular matrix interactions 15 4.19e-01 5.45e-01 0.1530 -9.48e-02 0.120000 5.25e-01 4.20e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.73e-01 4.02e-01 0.1530 -7.84e-02 0.132000 5.15e-01 2.75e-01
Negative regulation of MAPK pathway 42 2.22e-01 3.45e-01 0.1530 -1.51e-01 -0.027500 9.11e-02 7.58e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 6.52e-01 7.40e-01 0.1530 1.51e-01 -0.027000 4.34e-01 8.89e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 5.15e-01 6.31e-01 0.1530 -1.45e-01 -0.048700 2.50e-01 7.00e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 5.15e-01 6.31e-01 0.1530 -1.45e-01 -0.048700 2.50e-01 7.00e-01
Complex I biogenesis 66 1.06e-01 1.99e-01 0.1520 -1.48e-01 -0.034800 3.70e-02 6.25e-01
Signaling by PDGF 48 1.06e-01 1.99e-01 0.1520 -1.50e-01 0.025900 7.18e-02 7.56e-01
RHO GTPases Activate ROCKs 18 5.56e-01 6.61e-01 0.1520 -1.46e-01 -0.042000 2.82e-01 7.58e-01
Mitochondrial translation initiation 90 5.80e-03 2.25e-02 0.1520 -1.19e-01 0.095500 5.17e-02 1.17e-01
RNA Polymerase III Transcription Termination 22 3.71e-01 5.02e-01 0.1520 -1.51e-01 0.018700 2.21e-01 8.79e-01
Amino acids regulate mTORC1 48 7.69e-02 1.57e-01 0.1520 -1.38e-01 0.063600 9.84e-02 4.46e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 5.31e-01 6.42e-01 0.1520 5.93e-02 -0.140000 7.22e-01 4.02e-01
Transport of connexons to the plasma membrane 12 5.31e-01 6.42e-01 0.1520 5.93e-02 -0.140000 7.22e-01 4.02e-01
p38MAPK events 13 4.75e-01 5.94e-01 0.1520 -1.05e-01 0.109000 5.10e-01 4.96e-01
FLT3 signaling through SRC family kinases 6 7.73e-01 8.40e-01 0.1520 -9.21e-03 0.151000 9.69e-01 5.21e-01
tRNA processing 128 7.31e-04 4.33e-03 0.1520 -1.20e-01 0.093000 1.94e-02 6.93e-02
Immune System 1841 3.92e-42 1.51e-39 0.1520 -1.24e-01 0.087700 1.43e-18 4.45e-10
Activation of BH3-only proteins 30 1.98e-01 3.17e-01 0.1510 -1.35e-01 0.068100 2.00e-01 5.19e-01
RHO GTPases activate IQGAPs 25 3.91e-01 5.19e-01 0.1510 -1.51e-01 -0.015400 1.92e-01 8.94e-01
FGFR1 ligand binding and activation 10 6.35e-01 7.28e-01 0.1510 2.14e-02 -0.150000 9.07e-01 4.12e-01
Fatty acyl-CoA biosynthesis 35 3.10e-01 4.42e-01 0.1510 -1.47e-01 -0.034600 1.32e-01 7.23e-01
Generic Transcription Pathway 1079 1.04e-24 1.34e-22 0.1510 -6.88e-02 0.134000 1.34e-04 9.24e-14
CHL1 interactions 8 6.53e-01 7.40e-01 0.1510 1.36e-01 -0.066200 5.07e-01 7.46e-01
DNA Replication 128 1.04e-03 5.62e-03 0.1510 -1.33e-01 0.071100 9.36e-03 1.65e-01
Sensory processing of sound by outer hair cells of the cochlea 41 3.43e-01 4.77e-01 0.1500 7.78e-02 0.129000 3.88e-01 1.54e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 5.56e-01 6.61e-01 0.1500 -1.49e-01 0.023000 3.54e-01 8.86e-01
Presynaptic depolarization and calcium channel opening 8 6.45e-01 7.34e-01 0.1500 8.18e-02 -0.126000 6.89e-01 5.37e-01
Cyclin E associated events during G1/S transition 73 2.28e-02 6.57e-02 0.1500 -1.37e-01 0.060300 4.23e-02 3.73e-01
ROS and RNS production in phagocytes 30 4.18e-01 5.45e-01 0.1500 -1.39e-01 -0.056000 1.87e-01 5.96e-01
RHOQ GTPase cycle 54 8.09e-02 1.64e-01 0.1500 -1.47e-01 0.031600 6.23e-02 6.88e-01
Mitochondrial translation 96 6.07e-03 2.33e-02 0.1500 -1.32e-01 0.070700 2.51e-02 2.31e-01
CaM pathway 28 3.21e-01 4.54e-01 0.1500 -2.44e-03 0.150000 9.82e-01 1.70e-01
Calmodulin induced events 28 3.21e-01 4.54e-01 0.1500 -2.44e-03 0.150000 9.82e-01 1.70e-01
Myoclonic epilepsy of Lafora 8 6.82e-01 7.64e-01 0.1500 -1.45e-01 0.038000 4.77e-01 8.52e-01
Purine catabolism 16 6.80e-01 7.63e-01 0.1500 -1.12e-01 -0.099400 4.38e-01 4.91e-01
Caspase activation via Death Receptors in the presence of ligand 16 5.02e-01 6.20e-01 0.1490 -1.48e-01 0.016900 3.05e-01 9.07e-01
Translesion synthesis by REV1 16 4.17e-01 5.43e-01 0.1490 -1.18e-01 0.090600 4.13e-01 5.30e-01
PRC2 methylates histones and DNA 27 2.72e-01 4.01e-01 0.1490 -1.42e-01 0.043800 2.01e-01 6.94e-01
Relaxin receptors 5 7.81e-01 8.47e-01 0.1490 4.98e-02 -0.140000 8.47e-01 5.87e-01
Gamma-carboxylation of protein precursors 6 8.52e-01 8.96e-01 0.1490 1.33e-01 0.067200 5.74e-01 7.75e-01
Mitochondrial translation elongation 90 7.21e-03 2.64e-02 0.1490 -1.08e-01 0.103000 7.79e-02 9.27e-02
Thrombin signalling through proteinase activated receptors (PARs) 27 2.71e-01 4.00e-01 0.1480 -1.41e-01 0.045200 2.03e-01 6.84e-01
RNA Polymerase I Promoter Clearance 64 4.56e-02 1.10e-01 0.1480 -1.41e-01 0.045200 5.04e-02 5.31e-01
RNA Polymerase I Transcription 64 4.56e-02 1.10e-01 0.1480 -1.41e-01 0.045200 5.04e-02 5.31e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 1.73e-01 2.87e-01 0.1480 -1.23e-01 0.081700 2.20e-01 4.17e-01
APC-Cdc20 mediated degradation of Nek2A 26 4.94e-01 6.12e-01 0.1480 -1.34e-01 -0.061500 2.36e-01 5.87e-01
Platelet homeostasis 69 2.38e-02 6.75e-02 0.1480 -1.08e-01 0.101000 1.21e-01 1.48e-01
Thromboxane signalling through TP receptor 20 3.47e-01 4.80e-01 0.1480 -1.24e-01 0.080100 3.37e-01 5.35e-01
Sulfide oxidation to sulfate 5 7.68e-01 8.38e-01 0.1470 -1.24e-01 0.079600 6.31e-01 7.58e-01
RHO GTPase Effectors 259 1.40e-06 2.10e-05 0.1470 -1.23e-01 0.081200 6.86e-04 2.45e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 623 7.47e-15 4.97e-13 0.1470 -9.57e-02 0.111000 4.50e-05 2.02e-06
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 7.27e-02 1.51e-01 0.1470 -1.43e-01 -0.035300 2.39e-02 5.76e-01
Insulin receptor signalling cascade 40 2.81e-01 4.10e-01 0.1470 -1.43e-01 -0.032400 1.17e-01 7.23e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 2.09e-02 6.17e-02 0.1470 -1.23e-01 0.080600 6.81e-02 2.31e-01
G2/M Transition 177 1.51e-04 1.13e-03 0.1470 -6.20e-02 0.133000 1.55e-01 2.27e-03
ABC-family proteins mediated transport 81 6.40e-02 1.39e-01 0.1470 -1.45e-01 -0.020600 2.39e-02 7.48e-01
Mitotic G2-G2/M phases 179 1.43e-04 1.07e-03 0.1460 -6.35e-02 0.131000 1.43e-01 2.41e-03
Amyloid fiber formation 51 2.09e-01 3.29e-01 0.1460 -1.41e-01 -0.035400 8.08e-02 6.62e-01
Defective C1GALT1C1 causes TNPS 10 6.15e-01 7.09e-01 0.1460 5.65e-02 -0.134000 7.57e-01 4.62e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 8.55e-01 8.98e-01 0.1450 6.07e-02 0.132000 7.97e-01 5.76e-01
Downregulation of ERBB2 signaling 24 3.59e-01 4.90e-01 0.1450 -1.43e-01 0.025700 2.26e-01 8.28e-01
Degradation of cysteine and homocysteine 12 5.96e-01 6.92e-01 0.1450 -1.42e-01 0.028700 3.95e-01 8.63e-01
Adaptive Immune System 771 1.51e-17 1.39e-15 0.1450 -9.34e-02 0.110000 1.02e-05 1.78e-07
RUNX1 regulates transcription of genes involved in BCR signaling 6 8.03e-01 8.60e-01 0.1450 -3.92e-03 -0.145000 9.87e-01 5.40e-01
Metabolism of steroids 123 1.76e-03 8.43e-03 0.1450 -9.23e-02 0.111000 7.71e-02 3.30e-02
RET signaling 32 2.33e-01 3.57e-01 0.1440 -1.38e-01 0.043100 1.77e-01 6.73e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.84e-01 8.48e-01 0.1440 -1.69e-02 0.143000 9.43e-01 5.44e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 7.84e-01 8.48e-01 0.1440 -1.69e-02 0.143000 9.43e-01 5.44e-01
Signaling by Leptin 10 7.70e-01 8.40e-01 0.1440 -1.32e-01 -0.057800 4.70e-01 7.52e-01
Signaling by Rho GTPases 607 6.86e-14 4.26e-12 0.1440 -9.07e-02 0.112000 1.35e-04 2.61e-06
Synthesis of DNA 108 4.12e-03 1.71e-02 0.1440 -9.11e-02 0.111000 1.02e-01 4.64e-02
Estrogen-dependent gene expression 96 8.17e-03 2.93e-02 0.1440 -8.04e-02 0.119000 1.74e-01 4.41e-02
Cilium Assembly 187 7.49e-05 6.49e-04 0.1430 -1.08e-01 0.094800 1.11e-02 2.53e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.33e-01 3.57e-01 0.1430 -1.26e-01 0.068400 2.34e-01 5.16e-01
RUNX3 regulates CDKN1A transcription 7 8.58e-01 9.00e-01 0.1430 1.02e-01 0.099700 6.39e-01 6.48e-01
Phase 2 - plateau phase 11 7.87e-01 8.48e-01 0.1420 -1.02e-01 -0.099200 5.57e-01 5.69e-01
Base-Excision Repair, AP Site Formation 29 2.35e-01 3.60e-01 0.1420 -8.96e-02 0.110000 4.04e-01 3.04e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 7.40e-02 1.52e-01 0.1420 -8.19e-02 0.116000 3.03e-01 1.45e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 7.40e-02 1.52e-01 0.1420 -8.19e-02 0.116000 3.03e-01 1.45e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 7.40e-02 1.52e-01 0.1420 -8.19e-02 0.116000 3.03e-01 1.45e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 7.40e-02 1.52e-01 0.1420 -8.19e-02 0.116000 3.03e-01 1.45e-01
Signaling by NOTCH1 in Cancer 53 7.40e-02 1.52e-01 0.1420 -8.19e-02 0.116000 3.03e-01 1.45e-01
eNOS activation 11 6.33e-01 7.25e-01 0.1420 -1.39e-01 0.029600 4.26e-01 8.65e-01
Metabolism 1827 1.24e-32 2.66e-30 0.1420 -1.35e-01 0.041600 7.79e-22 3.22e-03
Sodium/Proton exchangers 7 7.46e-01 8.17e-01 0.1410 -3.21e-02 0.138000 8.83e-01 5.29e-01
RHO GTPases activate PAKs 20 4.06e-01 5.33e-01 0.1410 -1.32e-01 0.050800 3.08e-01 6.94e-01
Transcriptional regulation by RUNX2 89 2.34e-02 6.69e-02 0.1410 -1.37e-01 0.035400 2.60e-02 5.63e-01
Mitochondrial translation termination 90 1.22e-02 4.04e-02 0.1410 -1.12e-01 0.086200 6.73e-02 1.57e-01
Metabolism of lipids 641 2.19e-12 1.11e-10 0.1410 -1.35e-01 0.040000 5.15e-09 8.43e-02
RAC2 GTPase cycle 85 1.78e-02 5.46e-02 0.1410 -1.22e-01 0.070200 5.14e-02 2.64e-01
PKA activation 15 5.60e-01 6.63e-01 0.1410 -1.66e-02 0.140000 9.12e-01 3.48e-01
Activation of HOX genes during differentiation 70 3.25e-02 8.41e-02 0.1410 -9.08e-02 0.107000 1.89e-01 1.20e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 3.25e-02 8.41e-02 0.1410 -9.08e-02 0.107000 1.89e-01 1.20e-01
RHO GTPase cycle 411 2.89e-09 8.55e-08 0.1410 -8.42e-02 0.113000 3.40e-03 8.96e-05
Scavenging by Class A Receptors 12 7.76e-01 8.42e-01 0.1410 -9.88e-02 -0.099900 5.53e-01 5.49e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 7.84e-01 8.48e-01 0.1400 -1.40e-01 -0.001300 5.21e-01 9.95e-01
Positive epigenetic regulation of rRNA expression 60 5.37e-02 1.24e-01 0.1400 -9.44e-02 0.104000 2.06e-01 1.65e-01
Adherens junctions interactions 38 3.09e-01 4.40e-01 0.1400 2.02e-02 0.139000 8.29e-01 1.39e-01
FGFR1b ligand binding and activation 5 8.91e-01 9.20e-01 0.1400 1.23e-01 0.067400 6.35e-01 7.94e-01
G-protein activation 19 4.20e-01 5.45e-01 0.1400 -1.26e-01 0.060600 3.41e-01 6.47e-01
ERBB2 Activates PTK6 Signaling 8 8.34e-01 8.86e-01 0.1400 -7.04e-02 -0.121000 7.30e-01 5.54e-01
Fatty acid metabolism 157 2.12e-02 6.23e-02 0.1400 -1.28e-01 -0.055300 5.53e-03 2.31e-01
Synthesis of diphthamide-EEF2 8 8.31e-01 8.83e-01 0.1400 -1.23e-01 -0.066800 5.48e-01 7.44e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 7.48e-01 8.18e-01 0.1400 1.03e-01 -0.094000 6.62e-01 6.90e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 23 5.97e-01 6.92e-01 0.1390 -1.20e-01 -0.071800 3.21e-01 5.51e-01
Signaling by Receptor Tyrosine Kinases 443 9.67e-08 2.09e-06 0.1390 -1.39e-01 0.012900 5.44e-07 6.42e-01
FGFR2 alternative splicing 25 3.03e-01 4.34e-01 0.1390 -1.12e-01 0.083000 3.33e-01 4.72e-01
PIP3 activates AKT signaling 234 3.69e-05 3.58e-04 0.1390 -1.29e-01 0.051600 6.52e-04 1.74e-01
Phase 0 - rapid depolarisation 24 3.88e-01 5.17e-01 0.1390 1.37e-01 -0.025500 2.46e-01 8.29e-01
Negative regulation of the PI3K/AKT network 91 7.71e-02 1.57e-01 0.1390 -1.35e-01 -0.032300 2.57e-02 5.94e-01
Glycosaminoglycan metabolism 98 9.84e-03 3.40e-02 0.1390 -8.11e-02 0.113000 1.65e-01 5.37e-02
Sulfur amino acid metabolism 22 5.46e-01 6.55e-01 0.1380 -1.34e-01 -0.034500 2.77e-01 7.79e-01
RAC3 GTPase cycle 87 9.74e-02 1.88e-01 0.1380 -1.33e-01 -0.038200 3.21e-02 5.38e-01
TCR signaling 110 6.06e-03 2.33e-02 0.1380 -1.14e-01 0.077600 3.83e-02 1.60e-01
Downstream signaling of activated FGFR1 22 6.24e-01 7.17e-01 0.1380 -1.15e-01 -0.076900 3.52e-01 5.32e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 5.81e-01 6.79e-01 0.1380 -1.25e-01 -0.057700 2.98e-01 6.32e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 1.66e-01 2.78e-01 0.1380 -1.16e-01 0.074300 2.10e-01 4.22e-01
G2 Phase 5 7.95e-01 8.54e-01 0.1380 -7.23e-02 0.117000 7.80e-01 6.49e-01
Drug ADME 57 1.30e-01 2.33e-01 0.1380 -1.05e-02 0.137000 8.91e-01 7.27e-02
Chondroitin sulfate biosynthesis 12 5.93e-01 6.90e-01 0.1380 -1.26e-01 0.054700 4.49e-01 7.43e-01
Platelet Aggregation (Plug Formation) 29 4.22e-01 5.48e-01 0.1380 -2.06e-02 -0.136000 8.48e-01 2.05e-01
RND3 GTPase cycle 35 2.03e-01 3.22e-01 0.1370 -7.19e-02 0.117000 4.62e-01 2.31e-01
Phospholipase C-mediated cascade; FGFR3 5 7.95e-01 8.54e-01 0.1370 7.52e-02 -0.115000 7.71e-01 6.57e-01
Metabolism of folate and pterines 16 4.73e-01 5.94e-01 0.1370 -9.21e-02 0.102000 5.24e-01 4.81e-01
Cyclin A:Cdk2-associated events at S phase entry 75 3.29e-02 8.48e-02 0.1370 -1.15e-01 0.074300 8.44e-02 2.66e-01
Glycogen storage diseases 13 6.79e-01 7.62e-01 0.1370 -1.36e-01 -0.018400 3.97e-01 9.08e-01
Potassium Channels 64 5.97e-02 1.33e-01 0.1360 1.20e-01 -0.064500 9.65e-02 3.72e-01
NFE2L2 regulates pentose phosphate pathway genes 8 6.91e-01 7.70e-01 0.1360 -9.27e-02 0.100000 6.50e-01 6.24e-01
Vitamin D (calciferol) metabolism 11 6.11e-01 7.06e-01 0.1360 -7.02e-02 0.117000 6.87e-01 5.02e-01
Maternal to zygotic transition (MZT) 72 6.75e-02 1.44e-01 0.1360 -1.34e-01 0.023600 4.91e-02 7.29e-01
Cholesterol biosynthesis 26 5.58e-01 6.61e-01 0.1360 6.07e-02 0.122000 5.92e-01 2.83e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 1.28e-01 2.31e-01 0.1360 -1.35e-01 -0.015700 5.27e-02 8.22e-01
RHOJ GTPase cycle 49 1.30e-01 2.33e-01 0.1360 -1.26e-01 0.049700 1.26e-01 5.47e-01
Transport of vitamins, nucleosides, and related molecules 31 3.66e-01 4.97e-01 0.1360 -1.36e-01 -0.001690 1.92e-01 9.87e-01
CLEC7A/inflammasome pathway 6 7.73e-01 8.40e-01 0.1360 -1.22e-01 0.059000 6.05e-01 8.03e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 4.63e-01 5.87e-01 0.1340 -1.34e-01 -0.007370 2.45e-01 9.49e-01
Ca2+ pathway 58 7.72e-02 1.57e-01 0.1330 -8.78e-02 0.100000 2.47e-01 1.86e-01
Regulated Necrosis 56 9.09e-02 1.79e-01 0.1330 -1.12e-01 0.071100 1.45e-01 3.57e-01
Nectin/Necl trans heterodimerization 5 8.47e-01 8.92e-01 0.1330 -1.02e-02 0.132000 9.68e-01 6.09e-01
MECP2 regulates neuronal receptors and channels 14 5.58e-01 6.61e-01 0.1320 -6.77e-02 0.113000 6.61e-01 4.64e-01
Interleukin-6 family signaling 20 6.89e-01 7.70e-01 0.1320 -9.01e-02 -0.096000 4.86e-01 4.57e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.36e-01 2.42e-01 0.1320 -1.25e-01 0.042500 1.20e-01 5.96e-01
Hedgehog ‘off’ state 92 2.84e-02 7.64e-02 0.1310 -1.23e-01 0.046200 4.14e-02 4.44e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 7.87e-01 8.48e-01 0.1310 1.89e-02 -0.130000 9.31e-01 5.51e-01
EPHA-mediated growth cone collapse 21 4.49e-01 5.73e-01 0.1310 -4.22e-02 0.124000 7.38e-01 3.24e-01
Sensing of DNA Double Strand Breaks 6 7.73e-01 8.40e-01 0.1310 -8.98e-02 0.095800 7.03e-01 6.85e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 3.94e-01 5.21e-01 0.1310 8.38e-02 0.101000 3.05e-01 2.17e-01
Synthesis of bile acids and bile salts 26 3.66e-01 4.97e-01 0.1310 -1.23e-01 0.046100 2.79e-01 6.84e-01
Amino acid transport across the plasma membrane 25 3.99e-01 5.27e-01 0.1300 -3.78e-02 0.124000 7.44e-01 2.82e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 7.16e-01 7.92e-01 0.1290 9.62e-02 -0.086600 6.38e-01 6.71e-01
Signaling by FGFR2 61 9.45e-02 1.84e-01 0.1290 -1.17e-01 0.054200 1.13e-01 4.64e-01
Gap junction trafficking 28 3.50e-01 4.82e-01 0.1290 -4.52e-02 0.121000 6.79e-01 2.68e-01
Intracellular signaling by second messengers 267 2.55e-05 2.64e-04 0.1290 -1.11e-01 0.065500 1.74e-03 6.56e-02
Diseases of programmed cell death 58 1.02e-01 1.94e-01 0.1290 -1.14e-01 0.060000 1.33e-01 4.29e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 1.30e-01 2.33e-01 0.1290 -1.26e-01 0.028500 9.50e-02 7.05e-01
Transcriptional regulation of granulopoiesis 44 3.10e-01 4.41e-01 0.1290 1.57e-02 0.128000 8.57e-01 1.42e-01
Glycosphingolipid biosynthesis 15 5.95e-01 6.91e-01 0.1290 -2.93e-02 0.125000 8.44e-01 4.01e-01
Lysine catabolism 11 7.38e-01 8.09e-01 0.1280 -1.28e-01 -0.009440 4.63e-01 9.57e-01
TNFs bind their physiological receptors 25 4.56e-01 5.81e-01 0.1280 1.27e-01 -0.012800 2.71e-01 9.12e-01
Collagen biosynthesis and modifying enzymes 46 1.55e-01 2.65e-01 0.1280 -9.49e-02 0.085400 2.65e-01 3.16e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 2.53e-01 3.81e-01 0.1270 -9.05e-02 0.089800 3.61e-01 3.65e-01
Nucleotide-like (purinergic) receptors 14 6.38e-01 7.29e-01 0.1270 -1.26e-01 0.017800 4.14e-01 9.08e-01
Translesion Synthesis by POLH 18 4.85e-01 6.04e-01 0.1270 -9.36e-02 0.086000 4.92e-01 5.28e-01
RAC1 GTPase cycle 172 1.32e-03 6.66e-03 0.1270 -6.55e-02 0.109000 1.38e-01 1.39e-02
Interconversion of nucleotide di- and triphosphates 27 4.21e-01 5.46e-01 0.1270 -1.25e-01 0.019200 2.60e-01 8.63e-01
MITF-M-regulated melanocyte development 113 1.30e-02 4.24e-02 0.1260 -1.07e-01 0.067400 4.99e-02 2.16e-01
Hemostasis 558 4.33e-10 1.46e-08 0.1260 -8.21e-02 0.095900 9.10e-04 1.07e-04
Cell junction organization 78 1.41e-01 2.47e-01 0.1260 1.79e-02 0.125000 7.84e-01 5.64e-02
Formation of the cornified envelope 37 5.28e-01 6.41e-01 0.1260 -9.72e-02 -0.080500 3.06e-01 3.97e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 7.87e-01 8.48e-01 0.1260 9.33e-02 0.084700 5.46e-01 5.83e-01
Reproduction 86 3.52e-02 9.01e-02 0.1260 -9.99e-02 0.076400 1.09e-01 2.21e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 4.82e-01 6.00e-01 0.1260 -1.25e-01 -0.011300 2.52e-01 9.17e-01
Other semaphorin interactions 16 5.61e-01 6.63e-01 0.1250 -4.90e-02 0.116000 7.34e-01 4.24e-01
Signaling by FGFR4 in disease 11 6.78e-01 7.61e-01 0.1250 -1.18e-01 0.043800 5.00e-01 8.01e-01
Metabolism of water-soluble vitamins and cofactors 116 1.81e-02 5.54e-02 0.1250 -4.04e-02 0.119000 4.53e-01 2.74e-02
Plasma lipoprotein remodeling 18 6.42e-01 7.32e-01 0.1250 1.89e-02 0.124000 8.90e-01 3.63e-01
Defective B3GAT3 causes JDSSDHD 12 6.30e-01 7.23e-01 0.1250 -7.88e-02 0.096700 6.36e-01 5.62e-01
EGFR interacts with phospholipase C-gamma 6 8.39e-01 8.90e-01 0.1250 -1.24e-01 0.009070 5.98e-01 9.69e-01
A tetrasaccharide linker sequence is required for GAG synthesis 18 5.05e-01 6.23e-01 0.1240 -9.93e-02 0.074400 4.66e-01 5.85e-01
Formation of paraxial mesoderm 52 1.37e-01 2.42e-01 0.1240 -8.88e-02 0.086600 2.68e-01 2.80e-01
Biological oxidations 143 9.13e-02 1.79e-01 0.1230 -9.95e-02 -0.073000 3.99e-02 1.32e-01
Growth hormone receptor signaling 20 6.31e-01 7.24e-01 0.1230 -2.39e-02 -0.121000 8.53e-01 3.48e-01
HS-GAG degradation 20 5.44e-01 6.54e-01 0.1230 -1.22e-01 0.019700 3.47e-01 8.79e-01
FGFRL1 modulation of FGFR1 signaling 7 7.95e-01 8.54e-01 0.1230 3.46e-02 -0.118000 8.74e-01 5.88e-01
FGFR4 ligand binding and activation 5 8.29e-01 8.83e-01 0.1230 8.63e-02 -0.087200 7.38e-01 7.36e-01
FGFR2 mutant receptor activation 23 5.50e-01 6.57e-01 0.1230 4.64e-03 0.123000 9.69e-01 3.09e-01
Cytokine Signaling in Immune system 668 3.41e-11 1.53e-09 0.1220 -9.26e-02 0.079900 4.45e-05 4.29e-04
Long-term potentiation 18 5.28e-01 6.40e-01 0.1220 1.07e-01 -0.058400 4.30e-01 6.68e-01
Signaling by NOTCH3 42 2.13e-01 3.33e-01 0.1220 -8.56e-02 0.086600 3.37e-01 3.32e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.53e-01 7.40e-01 0.1210 -4.02e-02 0.115000 8.02e-01 4.75e-01
Nervous system development 478 1.13e-06 1.74e-05 0.1210 -1.20e-01 0.017600 6.86e-06 5.09e-01
Acetylcholine regulates insulin secretion 9 7.73e-01 8.40e-01 0.1210 -1.40e-02 0.120000 9.42e-01 5.32e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 6.74e-01 7.59e-01 0.1210 2.50e-02 0.119000 8.54e-01 3.84e-01
Fibronectin matrix formation 6 8.05e-01 8.60e-01 0.1210 -7.49e-02 0.095100 7.51e-01 6.87e-01
Negative regulation of MET activity 18 5.25e-01 6.38e-01 0.1210 -9.92e-02 0.069300 4.66e-01 6.11e-01
RNA Polymerase III Transcription Initiation 36 2.78e-01 4.08e-01 0.1210 -6.69e-02 0.101000 4.87e-01 2.96e-01
Ca-dependent events 30 3.52e-01 4.84e-01 0.1210 -6.05e-02 0.104000 5.66e-01 3.23e-01
Downstream signaling of activated FGFR4 18 5.35e-01 6.46e-01 0.1200 -1.04e-01 0.061000 4.46e-01 6.54e-01
Synthesis of Ketone Bodies 6 8.07e-01 8.62e-01 0.1200 -7.96e-02 0.089700 7.36e-01 7.04e-01
Signaling by ERBB2 KD Mutants 20 5.56e-01 6.61e-01 0.1200 -1.18e-01 0.022700 3.63e-01 8.60e-01
MITF-M-dependent gene expression 84 6.17e-02 1.35e-01 0.1200 -5.00e-02 0.109000 4.28e-01 8.47e-02
Formation of tubulin folding intermediates by CCT/TriC 21 7.04e-01 7.84e-01 0.1200 -1.04e-01 -0.059300 4.10e-01 6.38e-01
Defective Intrinsic Pathway for Apoptosis 24 5.50e-01 6.57e-01 0.1190 -1.19e-01 -0.002500 3.12e-01 9.83e-01
Metabolism of fat-soluble vitamins 28 4.35e-01 5.60e-01 0.1190 -2.74e-02 0.116000 8.02e-01 2.89e-01
Nephrin family interactions 20 7.07e-01 7.86e-01 0.1190 5.18e-02 0.107000 6.88e-01 4.07e-01
Retinoid metabolism and transport 25 5.24e-01 6.37e-01 0.1180 -5.90e-03 0.118000 9.59e-01 3.07e-01
Regulation of CDH11 gene transcription 5 8.48e-01 8.93e-01 0.1180 -5.47e-02 0.105000 8.32e-01 6.85e-01
Germ layer formation at gastrulation 9 8.70e-01 9.07e-01 0.1180 6.82e-02 0.096200 7.23e-01 6.17e-01
Gap junction assembly 17 6.05e-01 7.01e-01 0.1180 1.13e-01 -0.031000 4.18e-01 8.25e-01
Leading Strand Synthesis 14 7.86e-01 8.48e-01 0.1170 4.80e-02 0.107000 7.56e-01 4.88e-01
Polymerase switching 14 7.86e-01 8.48e-01 0.1170 4.80e-02 0.107000 7.56e-01 4.88e-01
Axon guidance 459 4.22e-06 5.73e-05 0.1170 -1.16e-01 0.018200 2.09e-05 5.04e-01
Metabolism of vitamins and cofactors 167 4.46e-03 1.82e-02 0.1170 -5.67e-02 0.102000 2.06e-01 2.25e-02
Cell-Cell communication 110 5.39e-02 1.24e-01 0.1170 -1.41e-02 0.116000 7.98e-01 3.55e-02
Diseases of glycosylation 110 4.06e-02 1.01e-01 0.1170 -3.12e-02 0.112000 5.72e-01 4.15e-02
NOTCH2 intracellular domain regulates transcription 11 7.15e-01 7.91e-01 0.1160 -4.21e-02 0.108000 8.09e-01 5.34e-01
Keratinization 38 5.77e-01 6.77e-01 0.1160 -7.63e-02 -0.087300 4.16e-01 3.52e-01
WNT ligand biogenesis and trafficking 20 7.27e-01 8.00e-01 0.1160 -1.02e-01 -0.054300 4.29e-01 6.74e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 5.50e-01 6.57e-01 0.1160 -8.56e-02 0.077600 5.29e-01 5.69e-01
Semaphorin interactions 57 1.64e-01 2.76e-01 0.1160 -5.57e-02 0.101000 4.67e-01 1.86e-01
Cytochrome P450 - arranged by substrate type 39 3.47e-01 4.80e-01 0.1150 2.12e-02 -0.113000 8.19e-01 2.20e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 2.71e-02 7.37e-02 0.1150 -4.97e-02 0.104000 3.53e-01 5.21e-02
Glycogen breakdown (glycogenolysis) 13 6.53e-01 7.40e-01 0.1150 -7.44e-02 0.087700 6.42e-01 5.84e-01
Signaling by LTK 10 8.00e-01 8.58e-01 0.1150 7.89e-03 0.115000 9.66e-01 5.30e-01
Arachidonate production from DAG 5 8.58e-01 9.00e-01 0.1140 -5.11e-02 0.102000 8.43e-01 6.93e-01
RND1 GTPase cycle 36 3.30e-01 4.62e-01 0.1140 -5.47e-02 0.099800 5.70e-01 3.00e-01
AKT phosphorylates targets in the nucleus 10 7.86e-01 8.48e-01 0.1140 -6.72e-03 0.113000 9.71e-01 5.35e-01
Signal Transduction 2051 2.20e-26 3.54e-24 0.1130 -7.09e-02 0.088200 1.19e-07 4.46e-11
Cyclin D associated events in G1 47 2.69e-01 3.98e-01 0.1130 -1.08e-01 0.034300 2.01e-01 6.84e-01
G1 Phase 47 2.69e-01 3.98e-01 0.1130 -1.08e-01 0.034300 2.01e-01 6.84e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 3.28e-01 4.60e-01 0.1130 -9.33e-02 0.063100 3.33e-01 5.12e-01
Senescence-Associated Secretory Phenotype (SASP) 65 3.73e-01 5.04e-01 0.1130 -9.97e-02 -0.052300 1.64e-01 4.66e-01
Diseases of mitotic cell cycle 38 3.02e-01 4.33e-01 0.1130 -8.29e-02 0.076200 3.77e-01 4.17e-01
Receptor Mediated Mitophagy 11 7.19e-01 7.93e-01 0.1120 -5.74e-02 0.095800 7.42e-01 5.82e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 9.17e-01 9.38e-01 0.1110 -3.00e-02 -0.107000 9.08e-01 6.80e-01
Neurexins and neuroligins 38 6.07e-01 7.03e-01 0.1100 7.07e-02 0.084400 4.51e-01 3.68e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 6.02e-01 6.98e-01 0.1100 -1.10e-01 -0.002530 3.51e-01 9.83e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 8.12e-01 8.66e-01 0.1100 -8.35e-02 0.071000 7.02e-01 7.45e-01
FRS-mediated FGFR4 signaling 13 7.60e-01 8.29e-01 0.1090 -1.09e-01 -0.001050 4.95e-01 9.95e-01
P2Y receptors 10 7.98e-01 8.56e-01 0.1090 -1.08e-01 0.010200 5.54e-01 9.55e-01
Aggrephagy 34 6.56e-01 7.41e-01 0.1080 -7.50e-02 -0.077300 4.49e-01 4.36e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 8.05e-01 8.60e-01 0.1080 -1.07e-01 0.007540 5.57e-01 9.67e-01
RNA Polymerase III Abortive And Retractive Initiation 40 3.19e-01 4.51e-01 0.1070 -7.10e-02 0.080400 4.37e-01 3.79e-01
RNA Polymerase III Transcription 40 3.19e-01 4.51e-01 0.1070 -7.10e-02 0.080400 4.37e-01 3.79e-01
Antimicrobial peptides 34 3.92e-01 5.20e-01 0.1070 5.41e-02 -0.092400 5.85e-01 3.51e-01
TAK1-dependent IKK and NF-kappa-B activation 43 4.11e-01 5.38e-01 0.1070 -1.07e-01 0.001850 2.25e-01 9.83e-01
Assembly and cell surface presentation of NMDA receptors 34 4.23e-01 5.48e-01 0.1060 3.74e-02 -0.099200 7.06e-01 3.17e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 4.20e-01 5.46e-01 0.1060 -3.36e-02 0.101000 7.31e-01 3.03e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.42e-01 8.91e-01 0.1050 -1.04e-01 -0.017400 5.70e-01 9.24e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 8.85e-01 9.18e-01 0.1050 4.55e-02 0.094600 8.13e-01 6.23e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 7.88e-01 8.48e-01 0.1050 9.33e-02 0.048000 4.93e-01 7.24e-01
FGFR1c ligand binding and activation 8 8.42e-01 8.91e-01 0.1050 1.25e-02 -0.104000 9.51e-01 6.10e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 7.06e-01 7.85e-01 0.1050 -7.88e-03 -0.104000 9.53e-01 4.31e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 8.31e-01 8.83e-01 0.1050 -9.33e-02 -0.047300 5.46e-01 7.59e-01
Transcriptional Regulation by VENTX 39 4.46e-01 5.71e-01 0.1020 -1.45e-02 0.101000 8.75e-01 2.74e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 5.56e-01 6.61e-01 0.1020 -8.14e-02 0.061100 4.99e-01 6.12e-01
Pre-NOTCH Transcription and Translation 47 3.03e-01 4.34e-01 0.1020 -5.98e-02 0.082300 4.78e-01 3.29e-01
Activation of NMDA receptors and postsynaptic events 74 3.48e-01 4.80e-01 0.1020 -9.72e-02 -0.029400 1.48e-01 6.62e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 9.41e-01 9.51e-01 0.1020 -8.88e-02 -0.049200 7.31e-01 8.49e-01
Phenylalanine metabolism 5 8.80e-01 9.15e-01 0.1010 7.76e-02 -0.065200 7.64e-01 8.01e-01
TP53 Regulates Transcription of Cell Death Genes 43 4.27e-01 5.52e-01 0.1010 -1.07e-02 0.101000 9.04e-01 2.53e-01
Bile acid and bile salt metabolism 30 4.78e-01 5.98e-01 0.1010 -5.28e-02 0.086000 6.17e-01 4.15e-01
Gap junction trafficking and regulation 30 5.07e-01 6.25e-01 0.1010 -3.33e-02 0.095200 7.52e-01 3.67e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 8.12e-01 8.66e-01 0.1010 4.53e-02 0.089900 7.47e-01 5.21e-01
Interleukin-37 signaling 19 6.24e-01 7.17e-01 0.1000 -6.37e-02 0.077200 6.31e-01 5.60e-01
Diseases of metabolism 204 1.08e-02 3.68e-02 0.0999 -9.36e-02 0.034900 2.12e-02 3.91e-01
Signaling by Interleukins 390 3.82e-04 2.50e-03 0.0997 -9.77e-02 0.020200 9.29e-04 4.93e-01
Aquaporin-mediated transport 38 4.89e-01 6.08e-01 0.0996 -9.92e-02 0.008240 2.90e-01 9.30e-01
Linoleic acid (LA) metabolism 7 9.24e-01 9.41e-01 0.0995 -8.36e-02 -0.054000 7.02e-01 8.05e-01
O-linked glycosylation 85 3.58e-01 4.89e-01 0.0994 4.33e-02 0.089500 4.90e-01 1.54e-01
Signaling by FGFR 73 1.85e-01 3.01e-01 0.0992 -8.86e-02 0.044700 1.91e-01 5.09e-01
Signaling by FGFR2 in disease 33 4.52e-01 5.77e-01 0.0988 -6.01e-02 0.078400 5.50e-01 4.36e-01
RAS processing 23 7.87e-01 8.48e-01 0.0983 -6.57e-02 -0.073100 5.86e-01 5.44e-01
Defects in cobalamin (B12) metabolism 13 7.64e-01 8.33e-01 0.0980 -2.69e-02 0.094200 8.66e-01 5.56e-01
Developmental Biology 924 1.06e-09 3.29e-08 0.0980 -8.23e-02 0.053100 2.21e-05 6.17e-03
Transcriptional regulation by RUNX3 80 2.02e-01 3.20e-01 0.0979 -9.54e-02 0.022100 1.40e-01 7.33e-01
PI3K Cascade 31 5.54e-01 6.61e-01 0.0977 -9.65e-02 0.015000 3.52e-01 8.85e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 5.58e-01 6.61e-01 0.0969 -6.65e-02 0.070400 5.65e-01 5.42e-01
Activation of C3 and C5 7 9.29e-01 9.44e-01 0.0963 8.03e-02 0.053200 7.13e-01 8.07e-01
Signaling by NOTCH2 33 4.70e-01 5.92e-01 0.0962 -5.97e-02 0.075500 5.53e-01 4.53e-01
RIPK1-mediated regulated necrosis 31 5.63e-01 6.64e-01 0.0961 -9.48e-02 0.015400 3.61e-01 8.82e-01
Regulation of necroptotic cell death 31 5.63e-01 6.64e-01 0.0961 -9.48e-02 0.015400 3.61e-01 8.82e-01
Formation of the nephric duct 8 8.81e-01 9.15e-01 0.0960 9.59e-02 0.004370 6.39e-01 9.83e-01
RUNX2 regulates osteoblast differentiation 19 8.21e-01 8.75e-01 0.0959 -8.03e-02 -0.052400 5.45e-01 6.92e-01
Erythrocytes take up carbon dioxide and release oxygen 11 8.45e-01 8.91e-01 0.0948 9.47e-02 0.004940 5.87e-01 9.77e-01
O2/CO2 exchange in erythrocytes 11 8.45e-01 8.91e-01 0.0948 9.47e-02 0.004940 5.87e-01 9.77e-01
Regulation of gene expression in beta cells 8 9.21e-01 9.40e-01 0.0946 4.93e-02 0.080800 8.09e-01 6.92e-01
Netrin mediated repulsion signals 5 9.41e-01 9.51e-01 0.0945 3.00e-02 0.089600 9.07e-01 7.29e-01
IRS-mediated signalling 35 5.71e-01 6.70e-01 0.0944 -9.44e-02 0.001250 3.34e-01 9.90e-01
Neurotransmitter release cycle 35 7.17e-01 7.92e-01 0.0941 7.01e-02 0.062800 4.73e-01 5.20e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 8.63e-01 9.03e-01 0.0940 9.23e-02 0.018000 5.96e-01 9.18e-01
FOXO-mediated transcription 58 3.74e-01 5.04e-01 0.0938 -9.33e-02 0.009870 2.19e-01 8.97e-01
G alpha (z) signalling events 36 5.89e-01 6.87e-01 0.0936 -9.34e-02 -0.006960 3.32e-01 9.42e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 5.60e-01 6.63e-01 0.0930 -8.04e-02 0.046700 4.62e-01 6.69e-01
SLC-mediated transmembrane transport 174 4.37e-02 1.06e-01 0.0927 -2.19e-02 0.090100 6.19e-01 4.03e-02
Regulation of CDH19 Expression and Function 6 8.85e-01 9.17e-01 0.0919 -4.87e-02 0.078000 8.36e-01 7.41e-01
FGFR3 ligand binding and activation 5 9.04e-01 9.30e-01 0.0908 7.44e-02 -0.052100 7.73e-01 8.40e-01
FGFR3c ligand binding and activation 5 9.04e-01 9.30e-01 0.0908 7.44e-02 -0.052100 7.73e-01 8.40e-01
SHC-mediated cascade:FGFR2 13 7.92e-01 8.52e-01 0.0903 8.58e-02 -0.028100 5.92e-01 8.61e-01
Transcriptional regulation of pluripotent stem cells 19 6.80e-01 7.63e-01 0.0902 6.49e-02 -0.062700 6.25e-01 6.36e-01
Intraflagellar transport 47 5.61e-01 6.63e-01 0.0899 -8.84e-02 -0.016700 2.95e-01 8.43e-01
Sialic acid metabolism 28 5.80e-01 6.79e-01 0.0896 -4.87e-02 0.075200 6.56e-01 4.91e-01
Transport of small molecules 556 2.07e-05 2.18e-04 0.0893 -6.35e-02 0.062800 1.05e-02 1.13e-02
Peptide ligand-binding receptors 102 1.38e-01 2.44e-01 0.0892 5.17e-02 -0.072700 3.67e-01 2.04e-01
Sensory perception of taste 22 6.78e-01 7.61e-01 0.0887 8.30e-02 -0.031200 5.01e-01 8.00e-01
Signalling to RAS 19 7.74e-01 8.40e-01 0.0885 -8.84e-02 -0.003560 5.05e-01 9.79e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 18 7.57e-01 8.27e-01 0.0883 -8.74e-02 0.012600 5.21e-01 9.26e-01
PI-3K cascade:FGFR2 13 8.94e-01 9.22e-01 0.0878 -7.26e-02 -0.049400 6.51e-01 7.58e-01
Signaling by ERBB2 TMD/JMD mutants 17 7.33e-01 8.06e-01 0.0878 -7.76e-02 0.041000 5.80e-01 7.70e-01
TNF signaling 56 3.48e-01 4.80e-01 0.0872 -6.60e-02 0.057000 3.93e-01 4.61e-01
Urea cycle 7 8.84e-01 9.17e-01 0.0871 7.91e-02 -0.036400 7.17e-01 8.68e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 5.16e-01 6.31e-01 0.0863 -8.61e-02 0.004380 3.02e-01 9.58e-01
Transport of RCbl within the body 8 8.63e-01 9.03e-01 0.0862 6.70e-02 -0.054200 7.43e-01 7.91e-01
RHOT2 GTPase cycle 7 9.02e-01 9.30e-01 0.0862 -8.53e-02 0.012000 6.96e-01 9.56e-01
Gastrulation 76 3.78e-01 5.09e-01 0.0861 -8.61e-02 -0.003130 1.95e-01 9.62e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 2.32e-01 3.57e-01 0.0858 -7.72e-02 0.037500 2.18e-01 5.50e-01
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 2.32e-01 3.57e-01 0.0858 -7.72e-02 0.037500 2.18e-01 5.50e-01
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 2.32e-01 3.57e-01 0.0858 -7.72e-02 0.037500 2.18e-01 5.50e-01
Striated Muscle Contraction 27 6.48e-01 7.37e-01 0.0852 2.75e-02 -0.080600 8.04e-01 4.68e-01
Glutathione synthesis and recycling 10 8.40e-01 8.91e-01 0.0837 -5.93e-02 0.059100 7.46e-01 7.46e-01
VEGF binds to VEGFR leading to receptor dimerization 5 9.21e-01 9.40e-01 0.0834 3.83e-02 -0.074100 8.82e-01 7.74e-01
VEGF ligand-receptor interactions 5 9.21e-01 9.40e-01 0.0834 3.83e-02 -0.074100 8.82e-01 7.74e-01
Deposition of new CENPA-containing nucleosomes at the centromere 38 5.94e-01 6.90e-01 0.0834 -8.26e-02 0.011300 3.78e-01 9.04e-01
Nucleosome assembly 38 5.94e-01 6.90e-01 0.0834 -8.26e-02 0.011300 3.78e-01 9.04e-01
Killing mechanisms 10 8.87e-01 9.19e-01 0.0831 -3.03e-03 -0.083000 9.87e-01 6.49e-01
WNT5:FZD7-mediated leishmania damping 10 8.87e-01 9.19e-01 0.0831 -3.03e-03 -0.083000 9.87e-01 6.49e-01
IGF1R signaling cascade 37 5.36e-01 6.46e-01 0.0829 -6.76e-02 0.048000 4.77e-01 6.13e-01
Integration of energy metabolism 88 2.42e-01 3.68e-01 0.0824 -7.24e-02 0.039500 2.41e-01 5.22e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 5.42e-01 6.51e-01 0.0824 -3.96e-02 0.072200 6.73e-01 4.41e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 7.78e-01 8.44e-01 0.0823 -4.34e-03 0.082200 9.73e-01 5.25e-01
Sensory Perception 194 3.95e-02 9.86e-02 0.0822 5.45e-02 -0.061500 1.91e-01 1.40e-01
SARS-CoV-2 modulates host translation machinery 49 6.57e-01 7.42e-01 0.0821 -7.57e-02 -0.032000 3.59e-01 6.99e-01
Activation of AMPK downstream of NMDARs 20 8.64e-01 9.03e-01 0.0819 -5.19e-02 -0.063400 6.88e-01 6.24e-01
Cell-cell junction organization 57 5.79e-01 6.79e-01 0.0817 2.05e-02 0.079100 7.89e-01 3.02e-01
Activation of G protein gated Potassium channels 19 8.43e-01 8.91e-01 0.0811 -2.51e-02 -0.077100 8.50e-01 5.61e-01
G protein gated Potassium channels 19 8.43e-01 8.91e-01 0.0811 -2.51e-02 -0.077100 8.50e-01 5.61e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 8.43e-01 8.91e-01 0.0811 -2.51e-02 -0.077100 8.50e-01 5.61e-01
RUNX2 regulates bone development 24 7.30e-01 8.02e-01 0.0804 -7.91e-02 0.014300 5.02e-01 9.03e-01
Activation of kainate receptors upon glutamate binding 26 6.71e-01 7.56e-01 0.0798 -6.82e-02 0.041500 5.47e-01 7.14e-01
Post NMDA receptor activation events 64 5.35e-01 6.46e-01 0.0790 -7.81e-02 -0.012100 2.80e-01 8.67e-01
SHC-mediated cascade:FGFR4 11 9.02e-01 9.30e-01 0.0790 -7.74e-02 -0.015800 6.57e-01 9.28e-01
Endogenous sterols 17 8.74e-01 9.11e-01 0.0790 -7.26e-02 -0.031200 6.04e-01 8.24e-01
Signaling by RNF43 mutants 7 9.47e-01 9.56e-01 0.0787 3.24e-02 0.071700 8.82e-01 7.43e-01
Blood group systems biosynthesis 17 8.29e-01 8.83e-01 0.0782 8.80e-04 -0.078200 9.95e-01 5.77e-01
G alpha (q) signalling events 139 1.69e-01 2.82e-01 0.0781 -1.84e-02 0.075900 7.09e-01 1.22e-01
Collagen formation 64 3.88e-01 5.17e-01 0.0776 -4.68e-02 0.061900 5.18e-01 3.91e-01
MET activates RAS signaling 10 8.92e-01 9.21e-01 0.0769 -7.65e-02 0.008000 6.75e-01 9.65e-01
GABA receptor activation 36 7.35e-01 8.06e-01 0.0757 -1.56e-02 -0.074100 8.71e-01 4.42e-01
Phase I - Functionalization of compounds 68 5.17e-01 6.32e-01 0.0740 -3.20e-04 -0.074000 9.96e-01 2.91e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 8.61e-01 9.02e-01 0.0738 -7.17e-02 0.017700 6.54e-01 9.12e-01
Interleukin-4 and Interleukin-13 signaling 92 3.28e-01 4.60e-01 0.0732 6.81e-02 -0.026900 2.59e-01 6.56e-01
RUNX3 regulates NOTCH signaling 14 8.45e-01 8.91e-01 0.0731 -2.55e-02 0.068500 8.69e-01 6.57e-01
Aspirin ADME 15 9.05e-01 9.30e-01 0.0731 3.01e-02 0.066600 8.40e-01 6.55e-01
Keratan sulfate/keratin metabolism 28 8.08e-01 8.63e-01 0.0728 1.83e-02 0.070500 8.67e-01 5.18e-01
Beta-oxidation of very long chain fatty acids 11 8.77e-01 9.13e-01 0.0727 6.81e-02 -0.025500 6.96e-01 8.83e-01
MAPK family signaling cascades 263 5.25e-02 1.22e-01 0.0722 -6.91e-02 0.021000 5.39e-02 5.58e-01
RA biosynthesis pathway 13 9.08e-01 9.31e-01 0.0722 1.87e-02 0.069700 9.07e-01 6.63e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.32e-01 9.46e-01 0.0722 -7.22e-03 0.071800 9.74e-01 7.42e-01
rRNA processing in the mitochondrion 24 8.78e-01 9.13e-01 0.0711 -5.25e-02 -0.047900 6.56e-01 6.84e-01
IRS-related events triggered by IGF1R 36 6.61e-01 7.45e-01 0.0709 -6.52e-02 0.027700 4.98e-01 7.73e-01
Regulation of TNFR1 signaling 47 6.10e-01 7.05e-01 0.0706 -1.69e-02 0.068500 8.41e-01 4.16e-01
Nicotinamide salvaging 16 9.10e-01 9.32e-01 0.0704 -6.19e-02 -0.033500 6.68e-01 8.17e-01
G alpha (i) signalling events 196 3.58e-01 4.89e-01 0.0701 -5.24e-02 -0.046500 2.06e-01 2.62e-01
Cardiac conduction 89 5.87e-01 6.85e-01 0.0694 2.85e-02 0.063200 6.42e-01 3.02e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 8.72e-01 9.09e-01 0.0694 -6.11e-02 -0.032800 6.04e-01 7.81e-01
NCAM1 interactions 26 8.52e-01 8.97e-01 0.0689 -6.41e-02 -0.025400 5.72e-01 8.22e-01
Integrin cell surface interactions 65 7.17e-01 7.92e-01 0.0689 -4.51e-02 -0.052100 5.30e-01 4.68e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 8.89e-01 9.20e-01 0.0677 -6.09e-02 0.029700 7.27e-01 8.65e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.65e-01 9.03e-01 0.0677 -2.44e-02 0.063100 8.74e-01 6.83e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.65e-01 9.03e-01 0.0677 -2.44e-02 0.063100 8.74e-01 6.83e-01
TNFR2 non-canonical NF-kB pathway 84 5.18e-01 6.32e-01 0.0662 -6.62e-02 0.000625 2.94e-01 9.92e-01
DNA methylation 18 8.82e-01 9.15e-01 0.0659 -6.54e-02 -0.007860 6.31e-01 9.54e-01
Uptake and actions of bacterial toxins 27 7.72e-01 8.40e-01 0.0645 -5.90e-02 0.026200 5.96e-01 8.14e-01
Degradation of the extracellular matrix 96 5.35e-01 6.46e-01 0.0636 -6.31e-02 -0.007300 2.85e-01 9.02e-01
Nicotinate metabolism 27 8.59e-01 9.00e-01 0.0635 -6.09e-02 -0.017800 5.84e-01 8.73e-01
Activation of Matrix Metalloproteinases 22 8.91e-01 9.20e-01 0.0634 5.93e-02 0.022500 6.30e-01 8.55e-01
Mitochondrial iron-sulfur cluster biogenesis 13 9.18e-01 9.38e-01 0.0630 6.28e-02 0.005110 6.95e-01 9.75e-01
PI3K/AKT Signaling in Cancer 84 4.45e-01 5.70e-01 0.0623 -4.32e-02 0.044900 4.93e-01 4.77e-01
Ion channel transport 141 3.76e-01 5.07e-01 0.0623 -6.52e-04 0.062300 9.89e-01 2.02e-01
O-linked glycosylation of mucins 47 7.25e-01 7.98e-01 0.0602 -6.00e-02 0.004660 4.76e-01 9.56e-01
Downregulation of ERBB2:ERBB3 signaling 12 8.98e-01 9.26e-01 0.0602 -4.52e-02 0.039700 7.86e-01 8.12e-01
Activation of RAS in B cells 5 9.80e-01 9.85e-01 0.0600 3.23e-02 0.050600 9.00e-01 8.45e-01
Pyrimidine catabolism 9 9.51e-01 9.59e-01 0.0595 -8.06e-03 -0.058900 9.67e-01 7.59e-01
Kidney development 17 8.65e-01 9.03e-01 0.0592 3.16e-02 -0.050100 8.22e-01 7.20e-01
Transcriptional regulation by RUNX1 170 2.49e-01 3.76e-01 0.0589 -2.77e-02 0.052000 5.33e-01 2.42e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 8.36e-01 8.88e-01 0.0584 -5.69e-02 0.013200 6.22e-01 9.09e-01
Signaling by GPCR 446 7.52e-02 1.55e-01 0.0577 1.44e-04 0.057700 9.96e-01 3.67e-02
GPCR downstream signalling 399 5.90e-02 1.32e-01 0.0575 -1.70e-02 0.055000 5.61e-01 5.95e-02
Amine ligand-binding receptors 10 9.30e-01 9.44e-01 0.0562 2.25e-02 -0.051500 9.02e-01 7.78e-01
Collagen degradation 42 8.54e-01 8.98e-01 0.0557 -4.97e-02 -0.025300 5.77e-01 7.77e-01
Regulation of FZD by ubiquitination 16 9.25e-01 9.41e-01 0.0554 -5.48e-02 -0.007880 7.04e-01 9.57e-01
MAPK1/MAPK3 signaling 231 1.86e-01 3.01e-01 0.0549 -4.53e-02 0.031000 2.36e-01 4.17e-01
TRP channels 22 9.32e-01 9.45e-01 0.0546 4.15e-02 0.035400 7.36e-01 7.74e-01
CASP8 activity is inhibited 11 9.25e-01 9.41e-01 0.0541 -2.98e-02 0.045200 8.64e-01 7.95e-01
Dimerization of procaspase-8 11 9.25e-01 9.41e-01 0.0541 -2.98e-02 0.045200 8.64e-01 7.95e-01
Regulation by c-FLIP 11 9.25e-01 9.41e-01 0.0541 -2.98e-02 0.045200 8.64e-01 7.95e-01
Neurotransmitter receptors and postsynaptic signal transmission 139 4.89e-01 6.08e-01 0.0537 -5.37e-02 0.000439 2.74e-01 9.93e-01
Sema4D in semaphorin signaling 22 9.14e-01 9.36e-01 0.0525 1.13e-02 0.051300 9.27e-01 6.77e-01
Interleukin-10 signaling 39 7.83e-01 8.48e-01 0.0503 3.76e-02 -0.033500 6.85e-01 7.18e-01
GPCR ligand binding 245 3.57e-01 4.88e-01 0.0495 4.95e-02 0.001660 1.82e-01 9.64e-01
Regulation of beta-cell development 22 9.10e-01 9.32e-01 0.0490 -4.16e-05 0.049000 1.00e+00 6.91e-01
Post-chaperonin tubulin folding pathway 18 9.35e-01 9.47e-01 0.0478 -4.77e-03 -0.047500 9.72e-01 7.27e-01
tRNA modification in the nucleus and cytosol 43 7.91e-01 8.51e-01 0.0474 -2.59e-02 0.039700 7.69e-01 6.52e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 9.34e-01 9.47e-01 0.0470 8.35e-03 0.046300 9.48e-01 7.20e-01
Transport of bile salts and organic acids, metal ions and amine compounds 53 8.56e-01 8.99e-01 0.0469 -4.42e-02 -0.015800 5.78e-01 8.42e-01
Regulation of insulin secretion 63 7.37e-01 8.07e-01 0.0469 -4.44e-02 0.015000 5.42e-01 8.37e-01
Molecules associated with elastic fibres 26 8.75e-01 9.11e-01 0.0466 2.15e-02 -0.041300 8.50e-01 7.15e-01
Class A/1 (Rhodopsin-like receptors) 177 4.07e-01 5.33e-01 0.0458 3.81e-02 -0.025500 3.82e-01 5.59e-01
Downstream signaling of activated FGFR2 20 9.35e-01 9.47e-01 0.0456 4.97e-03 0.045300 9.69e-01 7.26e-01
Collagen chain trimerization 27 9.27e-01 9.43e-01 0.0455 4.31e-02 0.014600 6.98e-01 8.95e-01
Tight junction interactions 17 9.16e-01 9.38e-01 0.0454 3.24e-02 -0.031800 8.17e-01 8.21e-01
CDC6 association with the ORC:origin complex 8 9.81e-01 9.85e-01 0.0453 -3.99e-02 -0.021300 8.45e-01 9.17e-01
Protein-protein interactions at synapses 58 8.91e-01 9.20e-01 0.0429 2.69e-02 0.033300 7.23e-01 6.60e-01
TNFR1-induced NF-kappa-B signaling pathway 32 9.23e-01 9.41e-01 0.0424 1.20e-02 0.040700 9.07e-01 6.91e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 9.41e-01 9.51e-01 0.0420 -1.14e-02 0.040400 9.37e-01 7.80e-01
The canonical retinoid cycle in rods (twilight vision) 9 9.83e-01 9.87e-01 0.0419 -2.70e-02 -0.032000 8.88e-01 8.68e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 9.41e-01 9.51e-01 0.0418 -2.82e-02 0.030900 8.55e-01 8.41e-01
RAF/MAP kinase cascade 225 3.92e-01 5.19e-01 0.0412 -3.23e-02 0.025600 4.03e-01 5.08e-01
Mitochondrial Uncoupling 6 9.87e-01 9.89e-01 0.0411 1.61e-02 0.037900 9.46e-01 8.72e-01
Extracellular matrix organization 219 4.71e-01 5.92e-01 0.0409 -4.00e-02 0.008540 3.07e-01 8.28e-01
Visual phototransduction 61 7.97e-01 8.55e-01 0.0408 3.83e-02 -0.014100 6.05e-01 8.49e-01
Formation of the Editosome 6 9.88e-01 9.89e-01 0.0398 -1.42e-02 -0.037100 9.52e-01 8.75e-01
mRNA Editing: C to U Conversion 6 9.88e-01 9.89e-01 0.0398 -1.42e-02 -0.037100 9.52e-01 8.75e-01
FRS-mediated FGFR2 signaling 15 9.50e-01 9.59e-01 0.0388 3.63e-02 -0.013700 8.07e-01 9.27e-01
Sema4D induced cell migration and growth-cone collapse 19 9.64e-01 9.72e-01 0.0378 1.26e-02 0.035700 9.24e-01 7.88e-01
Assembly of active LPL and LIPC lipase complexes 10 9.70e-01 9.76e-01 0.0376 1.00e-02 -0.036300 9.56e-01 8.43e-01
Ribavirin ADME 11 9.80e-01 9.85e-01 0.0369 -1.26e-02 -0.034700 9.42e-01 8.42e-01
Activation of GABAB receptors 30 9.07e-01 9.31e-01 0.0364 -2.22e-02 0.028800 8.34e-01 7.85e-01
GABA B receptor activation 30 9.07e-01 9.31e-01 0.0364 -2.22e-02 0.028800 8.34e-01 7.85e-01
Netrin-1 signaling 35 9.05e-01 9.30e-01 0.0354 3.28e-02 -0.013200 7.37e-01 8.92e-01
NCAM signaling for neurite out-growth 47 9.26e-01 9.42e-01 0.0349 1.15e-02 0.032900 8.91e-01 6.96e-01
Carboxyterminal post-translational modifications of tubulin 34 9.35e-01 9.47e-01 0.0312 3.08e-02 -0.005240 7.56e-01 9.58e-01
Assembly of collagen fibrils and other multimeric structures 42 9.04e-01 9.30e-01 0.0310 2.07e-02 -0.023100 8.16e-01 7.96e-01
Transmission across Chemical Synapses 183 7.22e-01 7.95e-01 0.0291 -2.81e-02 0.007360 5.12e-01 8.64e-01
L1CAM interactions 101 8.57e-01 9.00e-01 0.0290 -2.89e-02 0.000868 6.15e-01 9.88e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 9.69e-01 9.76e-01 0.0283 2.79e-02 0.004990 8.06e-01 9.65e-01
Lewis blood group biosynthesis 13 9.84e-01 9.87e-01 0.0282 -2.79e-02 -0.004330 8.62e-01 9.78e-01
CaMK IV-mediated phosphorylation of CREB 9 9.93e-01 9.93e-01 0.0230 -2.24e-02 -0.005440 9.08e-01 9.77e-01
Miscellaneous transport and binding events 20 9.85e-01 9.88e-01 0.0224 4.97e-03 0.021900 9.69e-01 8.66e-01
Muscle contraction 145 8.45e-01 8.91e-01 0.0219 -1.83e-02 0.012000 7.03e-01 8.03e-01
Elastic fibre formation 33 9.75e-01 9.80e-01 0.0178 1.05e-02 -0.014400 9.17e-01 8.86e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 9.69e-01 9.76e-01 0.0152 -1.33e-02 0.007310 8.62e-01 9.24e-01
Neuronal System 270 9.08e-01 9.31e-01 0.0144 1.44e-02 0.000444 6.84e-01 9.90e-01
Stimuli-sensing channels 80 9.90e-01 9.91e-01 0.0107 7.77e-03 0.007420 9.04e-01 9.09e-01


Detailed Gene set reports


Regulation of NFE2L2 gene expression
Regulation of NFE2L2 gene expression
metric value
setSize 8
pMANOVA 6.81e-05
p.adjustMANOVA 6e-04
s.dist 1.03
s.crp_t0_adj 0.583
s.avb_t0_adj 0.854
p.crp_t0_adj 0.00428
p.avb_t0_adj 2.87e-05



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NFKB1 10096 10743
NOTCH1 9662 11072
MYC 9706 8383
EP300 7435 9817
CREBBP 6506 10120
MAFK 7161 7046
RELA 2153 10854
NFE2L2 49 8118

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All member genes
crp_t0_adj avb_t0_adj
CREBBP 6506 10120
EP300 7435 9817
MAFK 7161 7046
MYC 9706 8383
NFE2L2 49 8118
NFKB1 10096 10743
NOTCH1 9662 11072
RELA 2153 10854



NFE2L2 regulating inflammation associated genes
NFE2L2 regulating inflammation associated genes
metric value
setSize 5
pMANOVA 0.016
p.adjustMANOVA 0.0505
s.dist 0.84
s.crp_t0_adj 0.415
s.avb_t0_adj 0.73
p.crp_t0_adj 0.108
p.avb_t0_adj 0.00468



Top 20 genes
Gene crp_t0_adj avb_t0_adj
EP300 7435 9817
CREBBP 6506 10120
MAFK 7161 7046
CCL2 2635 5734
NFE2L2 49 8118

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All member genes
crp_t0_adj avb_t0_adj
CCL2 2635 5734
CREBBP 6506 10120
EP300 7435 9817
MAFK 7161 7046
NFE2L2 49 8118



CYP2E1 reactions
CYP2E1 reactions
metric value
setSize 5
pMANOVA 0.0202
p.adjustMANOVA 0.0605
s.dist 0.839
s.crp_t0_adj 0.49
s.avb_t0_adj 0.681
p.crp_t0_adj 0.0578
p.avb_t0_adj 0.00836



Top 20 genes
Gene crp_t0_adj avb_t0_adj
CYP2D6 9605 9677
CYP2A6 8868 9110
CYP2S1 9653 8228
CYP2E1 6865 8934

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All member genes
crp_t0_adj avb_t0_adj
CYP2A6 8868 9110
CYP2C8 -7103 2192
CYP2D6 9605 9677
CYP2E1 6865 8934
CYP2S1 9653 8228



MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription of neuronal ligands
metric value
setSize 5
pMANOVA 0.0135
p.adjustMANOVA 0.0438
s.dist 0.809
s.crp_t0_adj 0.284
s.avb_t0_adj 0.757
p.crp_t0_adj 0.272
p.avb_t0_adj 0.00336



Top 20 genes
Gene crp_t0_adj avb_t0_adj
DLL1 10565 9455
HDAC1 6208 9498
MECP2 5451 10796
SIN3A 3269 10836

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All member genes
crp_t0_adj avb_t0_adj
CREB1 -8882 1733
DLL1 10565 9455
HDAC1 6208 9498
MECP2 5451 10796
SIN3A 3269 10836



Phosphorylation of Emi1
Phosphorylation of Emi1
metric value
setSize 6
pMANOVA 0.00727
p.adjustMANOVA 0.0265
s.dist 0.77
s.crp_t0_adj 0.225
s.avb_t0_adj 0.736
p.crp_t0_adj 0.339
p.avb_t0_adj 0.00179



Top 20 genes
Gene crp_t0_adj avb_t0_adj
PLK1 8271 10735
FZR1 8590 10113
FBXO5 7184 6962
CDC20 721 8896

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All member genes
crp_t0_adj avb_t0_adj
CCNB1 -5396 2908
CDC20 721 8896
CDK1 -3252 9765
FBXO5 7184 6962
FZR1 8590 10113
PLK1 8271 10735



Diseases of Base Excision Repair
Diseases of Base Excision Repair
metric value
setSize 5
pMANOVA 0.0384
p.adjustMANOVA 0.0966
s.dist 0.766
s.crp_t0_adj 0.446
s.avb_t0_adj 0.623
p.crp_t0_adj 0.0844
p.avb_t0_adj 0.0158



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NEIL1 9637 9114
OGG1 7861 5356
MUTYH 5501 5580
NTHL1 3944 7025

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All member genes
crp_t0_adj avb_t0_adj
MUTYH 5501 5580
NEIL1 9637 9114
NEIL3 -1473 7900
NTHL1 3944 7025
OGG1 7861 5356



NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
metric value
setSize 7
pMANOVA 0.000499
p.adjustMANOVA 0.00315
s.dist 0.759
s.crp_t0_adj -0.0548
s.avb_t0_adj 0.757
p.crp_t0_adj 0.802
p.avb_t0_adj 0.000522



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NCOA1 -5777 7827
NR1H3 -2274 10512
NR1H2 -2726 3923
RXRA -555 9602
NCOR2 -130 8884

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
NCOA1 -5777 7827
NCOR1 6476 8490
NCOR2 -130 8884
NR1H2 -2726 3923
NR1H3 -2274 10512
RXRA -555 9602
RXRB 2345 9977



Interleukin-21 signaling
Interleukin-21 signaling
metric value
setSize 9
pMANOVA 0.00107
p.adjustMANOVA 0.00576
s.dist 0.749
s.crp_t0_adj 0.237
s.avb_t0_adj 0.71
p.crp_t0_adj 0.218
p.avb_t0_adj 0.000225



Top 20 genes
Gene crp_t0_adj avb_t0_adj
IL21R 10863 10699
JAK3 10643 10372
IL2RG 10758 7473
STAT3 3517 10343

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
IL21R 10863 10699
IL2RG 10758 7473
JAK1 -1590 9482
JAK3 10643 10372
STAT1 -34 1409
STAT3 3517 10343
STAT4 -3155 6112
STAT5A -996 9870
STAT5B -4676 5733



Loss of MECP2 binding ability to the NCoR/SMRT complex
Loss of MECP2 binding ability to the NCoR/SMRT complex
metric value
setSize 7
pMANOVA 0.00377
p.adjustMANOVA 0.0159
s.dist 0.718
s.crp_t0_adj 0.122
s.avb_t0_adj 0.708
p.crp_t0_adj 0.577
p.avb_t0_adj 0.00118



Top 20 genes
Gene crp_t0_adj avb_t0_adj
GPS2 6830 10592
MECP2 5451 10796
NCOR1 6476 8490
TBL1X 594 7097

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
GPS2 6830 10592
HDAC3 -6336 6399
MECP2 5451 10796
NCOR1 6476 8490
NCOR2 -130 8884
TBL1X 594 7097
TBL1XR1 -2011 3190



Phosphate bond hydrolysis by NTPDase proteins
Phosphate bond hydrolysis by NTPDase proteins
metric value
setSize 5
pMANOVA 0.00955
p.adjustMANOVA 0.0332
s.dist 0.711
s.crp_t0_adj -0.71
s.avb_t0_adj 0.0294
p.crp_t0_adj 0.00596
p.avb_t0_adj 0.91



Top 20 genes
Gene crp_t0_adj avb_t0_adj
ENTPD7 -3217 7842
ENTPD6 -9757 2246
ENTPD5 -7178 533

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ENTPD1 -8429 -4057
ENTPD4 -9131 -4042
ENTPD5 -7178 533
ENTPD6 -9757 2246
ENTPD7 -3217 7842



NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
metric value
setSize 5
pMANOVA 0.01
p.adjustMANOVA 0.0347
s.dist 0.699
s.crp_t0_adj -0.0499
s.avb_t0_adj 0.697
p.crp_t0_adj 0.847
p.avb_t0_adj 0.00693



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NR1H3 -2274 10512
NR1H2 -2726 3923
RXRA -555 9602

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
NR1H2 -2726 3923
NR1H3 -2274 10512
PLIN1 1592 5014
RXRA -555 9602
RXRB 2345 9977



Wax and plasmalogen biosynthesis
Wax and plasmalogen biosynthesis
metric value
setSize 5
pMANOVA 0.0477
p.adjustMANOVA 0.114
s.dist 0.695
s.crp_t0_adj -0.637
s.avb_t0_adj -0.279
p.crp_t0_adj 0.0137
p.avb_t0_adj 0.281



Top 20 genes
Gene crp_t0_adj avb_t0_adj
FAR2 -10315 -10241
GNPAT -7517 -2233
AGPS -7521 -2023
FAR1 -6406 -1953

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
AGPS -7521 -2023
DHRS7B -1928 2135
FAR1 -6406 -1953
FAR2 -10315 -10241
GNPAT -7517 -2233



Branched-chain ketoacid dehydrogenase kinase deficiency
Branched-chain ketoacid dehydrogenase kinase deficiency
metric value
setSize 5
pMANOVA 0.048
p.adjustMANOVA 0.114
s.dist 0.692
s.crp_t0_adj -0.636
s.avb_t0_adj -0.273
p.crp_t0_adj 0.0138
p.avb_t0_adj 0.291



Top 20 genes
Gene crp_t0_adj avb_t0_adj
DLD -9782 -6155
BCKDHB -6081 -7577
DBT -5926 -4880

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
BCKDHA -5881 366
BCKDHB -6081 -7577
BCKDK -5985 4249
DBT -5926 -4880
DLD -9782 -6155



Protein repair
Protein repair
metric value
setSize 6
pMANOVA 0.048
p.adjustMANOVA 0.114
s.dist 0.685
s.crp_t0_adj -0.517
s.avb_t0_adj -0.449
p.crp_t0_adj 0.0282
p.avb_t0_adj 0.057



Top 20 genes
Gene crp_t0_adj avb_t0_adj
MSRB2 -8058 -8707
PCMT1 -9478 -6325
TXN -9480 -6321
MSRB3 -4901 -4256
MSRA -1461 -3417

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
MSRA -1461 -3417
MSRB1 771 702
MSRB2 -8058 -8707
MSRB3 -4901 -4256
PCMT1 -9478 -6325
TXN -9480 -6321



H139Hfs13* PPM1K causes a mild variant of MSUD
H139Hfs13* PPM1K causes a mild variant of MSUD
metric value
setSize 5
pMANOVA 0.074
p.adjustMANOVA 0.152
s.dist 0.682
s.crp_t0_adj -0.562
s.avb_t0_adj -0.386
p.crp_t0_adj 0.0295
p.avb_t0_adj 0.135



Top 20 genes
Gene crp_t0_adj avb_t0_adj
DLD -9782 -6155
BCKDHB -6081 -7577
DBT -5926 -4880
PPM1K -1941 -1958

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
BCKDHA -5881 366
BCKDHB -6081 -7577
DBT -5926 -4880
DLD -9782 -6155
PPM1K -1941 -1958



Maple Syrup Urine Disease
Maple Syrup Urine Disease
metric value
setSize 5
pMANOVA 0.074
p.adjustMANOVA 0.152
s.dist 0.682
s.crp_t0_adj -0.562
s.avb_t0_adj -0.386
p.crp_t0_adj 0.0295
p.avb_t0_adj 0.135



Top 20 genes
Gene crp_t0_adj avb_t0_adj
DLD -9782 -6155
BCKDHB -6081 -7577
DBT -5926 -4880
PPM1K -1941 -1958

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
BCKDHA -5881 366
BCKDHB -6081 -7577
DBT -5926 -4880
DLD -9782 -6155
PPM1K -1941 -1958



POLB-Dependent Long Patch Base Excision Repair
POLB-Dependent Long Patch Base Excision Repair
metric value
setSize 8
pMANOVA 0.00435
p.adjustMANOVA 0.0178
s.dist 0.68
s.crp_t0_adj 0.155
s.avb_t0_adj 0.663
p.crp_t0_adj 0.449
p.avb_t0_adj 0.00117



Top 20 genes
Gene crp_t0_adj avb_t0_adj
FEN1 9910 10998
LIG1 8681 6458
PARP2 8329 6015
PARP1 4842 9897
ADPRS 2005 10298

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ADPRS 2005 10298
APEX1 -3541 4656
FEN1 9910 10998
LIG1 8681 6458
PARG -5936 6384
PARP1 4842 9897
PARP2 8329 6015
POLB -9002 4708



Abacavir ADME
Abacavir ADME
metric value
setSize 5
pMANOVA 0.0767
p.adjustMANOVA 0.157
s.dist 0.675
s.crp_t0_adj 0.562
s.avb_t0_adj 0.374
p.crp_t0_adj 0.0295
p.avb_t0_adj 0.148



Top 20 genes
Gene crp_t0_adj avb_t0_adj
ABCB1 10074 8182
ADAL 7207 8454
SLC22A1 11051 3367
ABCG2 9416 1260

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ABCB1 10074 8182
ABCG2 9416 1260
ADAL 7207 8454
NT5C2 -5921 74
SLC22A1 11051 3367



SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is conjugated to E1 (UBA2:SAE1)
metric value
setSize 5
pMANOVA 0.0175
p.adjustMANOVA 0.0541
s.dist 0.673
s.crp_t0_adj -0.673
s.avb_t0_adj 0.00202
p.crp_t0_adj 0.00918
p.avb_t0_adj 0.994



Top 20 genes
Gene crp_t0_adj avb_t0_adj
SAE1 -5393 8711
SUMO3 -4502 4394

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
SAE1 -5393 8711
SUMO1 -9821 -698
SUMO2 -7700 -5932
SUMO3 -4502 4394
UBA2 -8248 -5447



Calcitonin-like ligand receptors
Calcitonin-like ligand receptors
metric value
setSize 5
pMANOVA 0.0554
p.adjustMANOVA 0.126
s.dist 0.666
s.crp_t0_adj 0.621
s.avb_t0_adj 0.241
p.crp_t0_adj 0.0161
p.avb_t0_adj 0.35



Top 20 genes
Gene crp_t0_adj avb_t0_adj
ADM2 10898 9532
RAMP1 8194 7922
CALCB 9193 4701

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ADM 10623 -9926
ADM2 10898 9532
CALCB 9193 4701
CALCRL -3844 1869
RAMP1 8194 7922



SUMO is proteolytically processed
SUMO is proteolytically processed
metric value
setSize 6
pMANOVA 0.00715
p.adjustMANOVA 0.0263
s.dist 0.653
s.crp_t0_adj -0.649
s.avb_t0_adj 0.0692
p.crp_t0_adj 0.00589
p.avb_t0_adj 0.769



Top 20 genes
Gene crp_t0_adj avb_t0_adj
SENP2 -9962 4763
SUMO3 -4502 4394
SENP5 -4801 3324

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
SENP1 -4462 -212
SENP2 -9962 4763
SENP5 -4801 3324
SUMO1 -9821 -698
SUMO2 -7700 -5932
SUMO3 -4502 4394



Acetylcholine binding and downstream events
Acetylcholine binding and downstream events
metric value
setSize 5
pMANOVA 0.0702
p.adjustMANOVA 0.147
s.dist 0.65
s.crp_t0_adj 0.262
s.avb_t0_adj 0.595
p.crp_t0_adj 0.31
p.avb_t0_adj 0.0213



Top 20 genes
Gene crp_t0_adj avb_t0_adj
CHRNB2 10983 11053
CHRNA2 7776 8603
CHRNA5 468 2905

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CHRNA2 7776 8603
CHRNA5 468 2905
CHRNA7 -3480 1914
CHRNB2 10983 11053
CHRNE -317 8945



Postsynaptic nicotinic acetylcholine receptors
Postsynaptic nicotinic acetylcholine receptors
metric value
setSize 5
pMANOVA 0.0702
p.adjustMANOVA 0.147
s.dist 0.65
s.crp_t0_adj 0.262
s.avb_t0_adj 0.595
p.crp_t0_adj 0.31
p.avb_t0_adj 0.0213



Top 20 genes
Gene crp_t0_adj avb_t0_adj
CHRNB2 10983 11053
CHRNA2 7776 8603
CHRNA5 468 2905

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CHRNA2 7776 8603
CHRNA5 468 2905
CHRNA7 -3480 1914
CHRNB2 10983 11053
CHRNE -317 8945



Formation of the ureteric bud
Formation of the ureteric bud
metric value
setSize 5
pMANOVA 0.1
p.adjustMANOVA 0.191
s.dist 0.647
s.crp_t0_adj -0.392
s.avb_t0_adj -0.515
p.crp_t0_adj 0.129
p.avb_t0_adj 0.0463



Top 20 genes
Gene crp_t0_adj avb_t0_adj
ITGB1 -5095 -9802
RET -8226 -3876
GREM1 -1485 -9359
FOXC1 -1795 -7155

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
FOXC1 -1795 -7155
GREM1 -1485 -9359
ITGB1 -5095 -9802
RET -8226 -3876
WNT11 -3741 2980



Phosphate bond hydrolysis by NUDT proteins
Phosphate bond hydrolysis by NUDT proteins
metric value
setSize 7
pMANOVA 0.0248
p.adjustMANOVA 0.0694
s.dist 0.645
s.crp_t0_adj -0.593
s.avb_t0_adj -0.253
p.crp_t0_adj 0.00658
p.avb_t0_adj 0.247



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NUDT16 -10602 -10696
NUDT15 -10680 -9255
NUDT9 -8113 -2483
NUDT5 -9910 -1607
ADPRM -8488 -1088

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ADPRM -8488 -1088
NUDT1 1074 7912
NUDT15 -10680 -9255
NUDT16 -10602 -10696
NUDT18 2888 -829
NUDT5 -9910 -1607
NUDT9 -8113 -2483



Disorders of Developmental Biology
Disorders of Developmental Biology
metric value
setSize 12
pMANOVA 0.000856
p.adjustMANOVA 0.00488
s.dist 0.639
s.crp_t0_adj 0.159
s.avb_t0_adj 0.619
p.crp_t0_adj 0.341
p.avb_t0_adj 0.000204



Top 20 genes
Gene crp_t0_adj avb_t0_adj
GPS2 6830 10592
HDAC1 6208 9498
MECP2 5451 10796
NCOR1 6476 8490
SIN3A 3269 10836
CAMK4 6965 2557
TBL1X 594 7097

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CALM1 -1272 -2500
CAMK4 6965 2557
GPS2 6830 10592
HDAC1 6208 9498
HDAC3 -6336 6399
MECP2 5451 10796
NCOR1 6476 8490
NCOR2 -130 8884
PRKACA -2566 7564
SIN3A 3269 10836
TBL1X 594 7097
TBL1XR1 -2011 3190



Disorders of Nervous System Development
Disorders of Nervous System Development
metric value
setSize 12
pMANOVA 0.000856
p.adjustMANOVA 0.00488
s.dist 0.639
s.crp_t0_adj 0.159
s.avb_t0_adj 0.619
p.crp_t0_adj 0.341
p.avb_t0_adj 0.000204



Top 20 genes
Gene crp_t0_adj avb_t0_adj
GPS2 6830 10592
HDAC1 6208 9498
MECP2 5451 10796
NCOR1 6476 8490
SIN3A 3269 10836
CAMK4 6965 2557
TBL1X 594 7097

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CALM1 -1272 -2500
CAMK4 6965 2557
GPS2 6830 10592
HDAC1 6208 9498
HDAC3 -6336 6399
MECP2 5451 10796
NCOR1 6476 8490
NCOR2 -130 8884
PRKACA -2566 7564
SIN3A 3269 10836
TBL1X 594 7097
TBL1XR1 -2011 3190



Loss of function of MECP2 in Rett syndrome
Loss of function of MECP2 in Rett syndrome
metric value
setSize 12
pMANOVA 0.000856
p.adjustMANOVA 0.00488
s.dist 0.639
s.crp_t0_adj 0.159
s.avb_t0_adj 0.619
p.crp_t0_adj 0.341
p.avb_t0_adj 0.000204



Top 20 genes
Gene crp_t0_adj avb_t0_adj
GPS2 6830 10592
HDAC1 6208 9498
MECP2 5451 10796
NCOR1 6476 8490
SIN3A 3269 10836
CAMK4 6965 2557
TBL1X 594 7097

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CALM1 -1272 -2500
CAMK4 6965 2557
GPS2 6830 10592
HDAC1 6208 9498
HDAC3 -6336 6399
MECP2 5451 10796
NCOR1 6476 8490
NCOR2 -130 8884
PRKACA -2566 7564
SIN3A 3269 10836
TBL1X 594 7097
TBL1XR1 -2011 3190



Pervasive developmental disorders
Pervasive developmental disorders
metric value
setSize 12
pMANOVA 0.000856
p.adjustMANOVA 0.00488
s.dist 0.639
s.crp_t0_adj 0.159
s.avb_t0_adj 0.619
p.crp_t0_adj 0.341
p.avb_t0_adj 0.000204



Top 20 genes
Gene crp_t0_adj avb_t0_adj
GPS2 6830 10592
HDAC1 6208 9498
MECP2 5451 10796
NCOR1 6476 8490
SIN3A 3269 10836
CAMK4 6965 2557
TBL1X 594 7097

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CALM1 -1272 -2500
CAMK4 6965 2557
GPS2 6830 10592
HDAC1 6208 9498
HDAC3 -6336 6399
MECP2 5451 10796
NCOR1 6476 8490
NCOR2 -130 8884
PRKACA -2566 7564
SIN3A 3269 10836
TBL1X 594 7097
TBL1XR1 -2011 3190



Eicosanoids
Eicosanoids
metric value
setSize 8
pMANOVA 0.0018
p.adjustMANOVA 0.00859
s.dist 0.639
s.crp_t0_adj 0.0688
s.avb_t0_adj -0.635
p.crp_t0_adj 0.736
p.avb_t0_adj 0.00186



Top 20 genes
Gene crp_t0_adj avb_t0_adj
CYP4F3 9847 -8255
CYP4F22 5938 -5781
PTGIS 4210 -6917
CYP4F11 2765 -7314
CYP4F2 3578 -3844

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CYP4F11 2765 -7314
CYP4F12 -4292 -3995
CYP4F2 3578 -3844
CYP4F22 5938 -5781
CYP4F3 9847 -8255
CYP4F8 -3611 -9247
PTGIS 4210 -6917
TBXAS1 -10645 -8735



NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating MDR associated enzymes
metric value
setSize 8
pMANOVA 0.0288
p.adjustMANOVA 0.0772
s.dist 0.639
s.crp_t0_adj 0.405
s.avb_t0_adj 0.495
p.crp_t0_adj 0.0476
p.avb_t0_adj 0.0154



Top 20 genes
Gene crp_t0_adj avb_t0_adj
EP300 7435 9817
CREBBP 6506 10120
ABCC1 7152 7579
MAFK 7161 7046
ABCG2 9416 1260
NFE2L2 49 8118

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ABCC1 7152 7579
ABCC3 610 -2645
ABCF2 -1184 3419
ABCG2 9416 1260
CREBBP 6506 10120
EP300 7435 9817
MAFK 7161 7046
NFE2L2 49 8118



Unwinding of DNA
Unwinding of DNA
metric value
setSize 12
pMANOVA 0.00433
p.adjustMANOVA 0.0178
s.dist 0.638
s.crp_t0_adj 0.367
s.avb_t0_adj 0.522
p.crp_t0_adj 0.0277
p.avb_t0_adj 0.00174



Top 20 genes
Gene crp_t0_adj avb_t0_adj
MCM3 6561 10933
GINS4 10416 6435
MCM7 6630 9118
MCM8 8742 5495
MCM2 3988 9384
GINS2 7802 4181
MCM5 3226 9313
MCM4 1073 10081
CDC45 898 8732

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CDC45 898 8732
GINS1 -3640 551
GINS2 7802 4181
GINS3 5299 -7315
GINS4 10416 6435
MCM2 3988 9384
MCM3 6561 10933
MCM4 1073 10081
MCM5 3226 9313
MCM6 -200 3742
MCM7 6630 9118
MCM8 8742 5495



PTK6 promotes HIF1A stabilization
PTK6 promotes HIF1A stabilization
metric value
setSize 6
pMANOVA 0.0726
p.adjustMANOVA 0.151
s.dist 0.638
s.crp_t0_adj -0.471
s.avb_t0_adj -0.429
p.crp_t0_adj 0.0456
p.avb_t0_adj 0.0686



Top 20 genes
Gene crp_t0_adj avb_t0_adj
LRRK2 -10109 -7970
LINC01139 -5034 -9846
GPNMB -5543 -6712
HBEGF -416 -9875

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
GPNMB -5543 -6712
HBEGF -416 -9875
HIF1A -9644 7064
LINC01139 -5034 -9846
LRRK2 -10109 -7970
PTK6 1158 283



Type I hemidesmosome assembly
Type I hemidesmosome assembly
metric value
setSize 8
pMANOVA 0.0131
p.adjustMANOVA 0.0427
s.dist 0.623
s.crp_t0_adj 0.177
s.avb_t0_adj 0.598
p.crp_t0_adj 0.386
p.avb_t0_adj 0.00342



Top 20 genes
Gene crp_t0_adj avb_t0_adj
PLEC 8958 8512
ITGB4 7556 7518
DST 5913 9598
ITGA6 3694 5988
COL17A1 383 5220

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
CD151 -1146 -3852
COL17A1 383 5220
DST 5913 9598
ITGA6 3694 5988
ITGB4 7556 7518
KRT5 -1950 10878
LAMB3 -6155 9868
PLEC 8958 8512



PDH complex synthesizes acetyl-CoA from PYR
PDH complex synthesizes acetyl-CoA from PYR
metric value
setSize 5
pMANOVA 0.0835
p.adjustMANOVA 0.168
s.dist 0.623
s.crp_t0_adj -0.575
s.avb_t0_adj -0.238
p.crp_t0_adj 0.0259
p.avb_t0_adj 0.357



Top 20 genes
Gene crp_t0_adj avb_t0_adj
DLAT -8559 -8142
DLD -9782 -6155

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
DLAT -8559 -8142
DLD -9782 -6155
PDHA1 -1919 1177
PDHB -4644 601
PDHX -5437 440



NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
metric value
setSize 8
pMANOVA 0.00176
p.adjustMANOVA 0.00843
s.dist 0.614
s.crp_t0_adj -0.142
s.avb_t0_adj 0.598
p.crp_t0_adj 0.487
p.avb_t0_adj 0.00342



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NR1H3 -2274 10512
NR1H2 -2726 3923
RXRA -555 9602
SREBF1 -115 10462

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
FASN 5024 10131
NR1H2 -2726 3923
NR1H3 -2274 10512
NRIP1 -5586 -658
RXRA -555 9602
RXRB 2345 9977
SCD -6756 -217
SREBF1 -115 10462



Activation of caspases through apoptosome-mediated cleavage
Activation of caspases through apoptosome-mediated cleavage
metric value
setSize 6
pMANOVA 0.0311
p.adjustMANOVA 0.0824
s.dist 0.609
s.crp_t0_adj -0.601
s.avb_t0_adj -0.0958
p.crp_t0_adj 0.0108
p.avb_t0_adj 0.684



Top 20 genes
Gene crp_t0_adj avb_t0_adj
CASP7 -9434 -8841
CYCS -5994 -8866
XIAP -3701 -4439

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
APAF1 -7805 1354
CASP3 -8463 6176
CASP7 -9434 -8841
CASP9 -2699 9433
CYCS -5994 -8866
XIAP -3701 -4439



Defective LFNG causes SCDO3
Defective LFNG causes SCDO3
metric value
setSize 5
pMANOVA 0.0412
p.adjustMANOVA 0.102
s.dist 0.605
s.crp_t0_adj 0.0181
s.avb_t0_adj 0.605
p.crp_t0_adj 0.944
p.avb_t0_adj 0.0191



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NOTCH1 9662 11072
LFNG 3050 10004

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
LFNG 3050 10004
NOTCH1 9662 11072
NOTCH2 -3795 1358
NOTCH3 -4760 4333
NOTCH4 -2061 7230



Repression of WNT target genes
Repression of WNT target genes
metric value
setSize 14
pMANOVA 0.00409
p.adjustMANOVA 0.017
s.dist 0.6
s.crp_t0_adj 0.372
s.avb_t0_adj 0.471
p.crp_t0_adj 0.0159
p.avb_t0_adj 0.0023



Top 20 genes
Gene crp_t0_adj avb_t0_adj
TLE3 7924 10880
TCF7 8659 9935
MYC 9706 8383
LEF1 9428 7766
TLE2 9106 7491
HDAC1 6208 9498
TLE5 7167 5774
CTBP1 4815 7533
AXIN2 5783 3076
TLE1 215 4196

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
AXIN2 5783 3076
CTBP1 4815 7533
CTBP2 -9894 1913
HDAC1 6208 9498
LEF1 9428 7766
MYC 9706 8383
TCF7 8659 9935
TCF7L1 1081 -6085
TCF7L2 3222 -2869
TLE1 215 4196
TLE2 9106 7491
TLE3 7924 10880
TLE4 -3405 7077
TLE5 7167 5774



Interleukin-9 signaling
Interleukin-9 signaling
metric value
setSize 8
pMANOVA 0.0231
p.adjustMANOVA 0.0662
s.dist 0.596
s.crp_t0_adj 0.205
s.avb_t0_adj 0.56
p.crp_t0_adj 0.316
p.avb_t0_adj 0.00608



Top 20 genes
Gene crp_t0_adj avb_t0_adj
JAK3 10643 10372
IL2RG 10758 7473
STAT3 3517 10343

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
IL2RG 10758 7473
IL9R 2061 -4231
JAK1 -1590 9482
JAK3 10643 10372
STAT1 -34 1409
STAT3 3517 10343
STAT5A -996 9870
STAT5B -4676 5733



NOTCH4 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
metric value
setSize 10
pMANOVA 0.00297
p.adjustMANOVA 0.0131
s.dist 0.59
s.crp_t0_adj -0.588
s.avb_t0_adj -0.0467
p.crp_t0_adj 0.00127
p.avb_t0_adj 0.798



Top 20 genes
Gene crp_t0_adj avb_t0_adj
YWHAZ -9856 -6209
ADAM10 -9570 -5059
JAG1 -9875 -4807
APH1B -5088 -7151
PSEN1 -7392 -1854

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ADAM10 -9570 -5059
APH1A -8858 523
APH1B -5088 -7151
JAG1 -9875 -4807
NCSTN -8931 2888
NOTCH4 -2061 7230
PSEN1 -7392 -1854
PSEN2 7437 6109
PSENEN -7897 5062
YWHAZ -9856 -6209



Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
metric value
setSize 6
pMANOVA 0.046
p.adjustMANOVA 0.111
s.dist 0.582
s.crp_t0_adj -0.571
s.avb_t0_adj -0.11
p.crp_t0_adj 0.0154
p.avb_t0_adj 0.639



Top 20 genes
Gene crp_t0_adj avb_t0_adj
MAPK1 -10540 -6248
NRAS -10257 -5375
PDPK1 -9575 -2270
KRAS -4290 -789

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
HRAS 6727 7004
KRAS -4290 -789
MAPK1 -10540 -6248
NRAS -10257 -5375
PDPK1 -9575 -2270
PRKCZ -8185 1536



DEx/H-box helicases activate type I IFN and inflammatory cytokines production
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
metric value
setSize 7
pMANOVA 0.0386
p.adjustMANOVA 0.0967
s.dist 0.578
s.crp_t0_adj 0.166
s.avb_t0_adj 0.554
p.crp_t0_adj 0.447
p.avb_t0_adj 0.0112



Top 20 genes
Gene crp_t0_adj avb_t0_adj
NFKB1 10096 10743
NFKB2 10089 9147
IRF7 5289 9038
RELA 2153 10854
MYD88 3042 7184

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
DHX36 -8807 -7245
DHX9 -7617 3926
IRF7 5289 9038
MYD88 3042 7184
NFKB1 10096 10743
NFKB2 10089 9147
RELA 2153 10854



Small interfering RNA (siRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
metric value
setSize 9
pMANOVA 0.0116
p.adjustMANOVA 0.0388
s.dist 0.577
s.crp_t0_adj -0.564
s.avb_t0_adj -0.123
p.crp_t0_adj 0.00338
p.avb_t0_adj 0.521



Top 20 genes
Gene crp_t0_adj avb_t0_adj
AGO4 -10483 -7255
PRKRA -9201 -6795
TSNAX -9517 -5084
DICER1 -5413 -4878
AGO3 -5848 -2134
TSN -10039 -439

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
AGO1 -7549 3473
AGO2 -669 6989
AGO3 -5848 -2134
AGO4 -10483 -7255
DICER1 -5413 -4878
PRKRA -9201 -6795
TARBP2 5218 5635
TSN -10039 -439
TSNAX -9517 -5084



NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
metric value
setSize 32
pMANOVA 8.9e-10
p.adjustMANOVA 2.81e-08
s.dist 0.577
s.crp_t0_adj -0.0718
s.avb_t0_adj 0.572
p.crp_t0_adj 0.482
p.avb_t0_adj 2.08e-08



Top 20 genes
Gene crp_t0_adj avb_t0_adj
ABCA1 -6832 9717
ABCG1 -8027 7938
NCOA1 -5777 7827
KDM1A -6253 7208
PLTP -9409 4590
HDAC3 -6336 6399
AGO1 -7549 3473
NR1H3 -2274 10512
EEPD1 -4293 4904
NR1H2 -2726 3923
KDM3A -928 8734
TBL1XR1 -2011 3190
RXRA -555 9602
AGO2 -669 6989
TNRC6B -1431 1209
NCOR2 -130 8884

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ABCA1 -6832 9717
ABCG1 -8027 7938
ABCG8 10005 10571
AGO1 -7549 3473
AGO2 -669 6989
AGO3 -5848 -2134
AGO4 -10483 -7255
APOE 10426 8778
ARL4C 24 7289
CETP 2713 2916
EEPD1 -4293 4904
EP300 7435 9817
GPS2 6830 10592
HDAC3 -6336 6399
KDM1A -6253 7208
KDM1B -6444 -3906
KDM3A -928 8734
KDM4A 5971 10838
MOV10 6162 9591
NCOA1 -5777 7827
NCOR1 6476 8490
NCOR2 -130 8884
NR1H2 -2726 3923
NR1H3 -2274 10512
PLTP -9409 4590
RXRA -555 9602
RXRB 2345 9977
TBL1X 594 7097
TBL1XR1 -2011 3190
TNRC6A 1323 9499
TNRC6B -1431 1209
TNRC6C 9664 8597



Formyl peptide receptors bind formyl peptides and many other ligands
Formyl peptide receptors bind formyl peptides and many other ligands
metric value
setSize 7
pMANOVA 0.0682
p.adjustMANOVA 0.144
s.dist 0.576
s.crp_t0_adj -0.495
s.avb_t0_adj -0.294
p.crp_t0_adj 0.0234
p.avb_t0_adj 0.178



Top 20 genes
Gene crp_t0_adj avb_t0_adj
ANXA1 -10663 -9314
FPR1 -7205 -9788
APP -9078 -3454
HEBP1 -6869 -2977
MT-RNR2 -7832 -1001

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ANXA1 -10663 -9314
APP -9078 -3454
FPR1 -7205 -9788
FPR2 3153 -5401
FPR3 2195 10707
HEBP1 -6869 -2977
MT-RNR2 -7832 -1001



Formation of xylulose-5-phosphate
Formation of xylulose-5-phosphate
metric value
setSize 5
pMANOVA 0.0487
p.adjustMANOVA 0.115
s.dist 0.57
s.crp_t0_adj -0.569
s.avb_t0_adj 0.0317
p.crp_t0_adj 0.0276
p.avb_t0_adj 0.902



Top 20 genes
Gene crp_t0_adj avb_t0_adj
DCXR -7632 6234
SORD -8209 4282
AKR1A1 -309 1000

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
AKR1A1 -309 1000
CRYL1 -9848 -7834
DCXR -7632 6234
SORD -8209 4282
XYLB -3993 -1034



Erythrocytes take up oxygen and release carbon dioxide
Erythrocytes take up oxygen and release carbon dioxide
metric value
setSize 7
pMANOVA 0.0585
p.adjustMANOVA 0.131
s.dist 0.57
s.crp_t0_adj 0.519
s.avb_t0_adj 0.235
p.crp_t0_adj 0.0174
p.avb_t0_adj 0.282



Top 20 genes
Gene crp_t0_adj avb_t0_adj
CA1 11140 8937
SLC4A1 11154 8645
HBB 11056 8654
HBA1 11118 8577

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
AQP1 -6335 -9930
CA1 11140 8937
CA2 -2593 -680
CA4 5732 -4946
HBA1 11118 8577
HBB 11056 8654
SLC4A1 11154 8645



Activation of PUMA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
metric value
setSize 9
pMANOVA 0.0217
p.adjustMANOVA 0.0631
s.dist 0.568
s.crp_t0_adj 0.198
s.avb_t0_adj 0.533
p.crp_t0_adj 0.303
p.avb_t0_adj 0.00566



Top 20 genes
Gene crp_t0_adj avb_t0_adj
TP73 10660 9906
TP53 5717 10452
TFDP2 4370 8824
BBC3 6444 5954
E2F1 4923 5203
TFDP1 1368 9449

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
BBC3 6444 5954
E2F1 4923 5203
PPP1R13B -6077 7988
TFDP1 1368 9449
TFDP2 4370 8824
TP53 5717 10452
TP53BP2 -6736 -3396
TP63 812 -336
TP73 10660 9906



Activation of the AP-1 family of transcription factors
Activation of the AP-1 family of transcription factors
metric value
setSize 10
pMANOVA 0.0318
p.adjustMANOVA 0.0831
s.dist 0.567
s.crp_t0_adj -0.411
s.avb_t0_adj -0.39
p.crp_t0_adj 0.0243
p.avb_t0_adj 0.0327



Top 20 genes
Gene crp_t0_adj avb_t0_adj
MAPK1 -10540 -6248
MAPK10 -4276 -9954
MAPK9 -9468 -3061
MAPK8 -8200 -1535
JUN -994 -10211
FOS -287 -9051

Click HERE to show all gene set members

All member genes
crp_t0_adj avb_t0_adj
ATF2 -9763 982
FOS -287 -9051
JUN -994 -10211
MAPK1 -10540 -6248
MAPK10 -4276 -9954
MAPK11 10208 -3958
MAPK14 -9420 220
MAPK3 7 2032
MAPK8 -8200 -1535
MAPK9 -9468 -3061



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] tibble_3.2.1                echarts4r_0.4.5            
##  [7] xlsx_0.6.5                  DT_0.33                    
##  [9] eulerr_7.0.2                ggplot2_3.5.1              
## [11] kableExtra_1.4.0            MASS_7.3-61                
## [13] mitch_1.17.4                DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         dplyr_1.1.4                
## [25] WGCNA_1.73                  fastcluster_1.2.6          
## [27] dynamicTreeCut_1.63-1       reshape2_1.4.4             
## [29] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3      rstudioapi_0.17.1       jsonlite_1.8.9         
##   [4] magrittr_2.0.3          farver_2.1.2            rmarkdown_2.28         
##   [7] zlibbioc_1.50.0         vctrs_0.6.5             memoise_2.0.1.9000     
##  [10] base64enc_0.1-3         progress_1.2.3          htmltools_0.5.8.1      
##  [13] S4Arrays_1.4.1          SparseArray_1.4.8       Formula_1.2-5          
##  [16] sass_0.4.9              KernSmooth_2.23-24      bslib_0.8.0            
##  [19] htmlwidgets_1.6.4       plyr_1.8.9              impute_1.78.0          
##  [22] cachem_1.1.0            mime_0.12               lifecycle_1.0.4        
##  [25] iterators_1.0.14        pkgconfig_2.0.3         Matrix_1.7-0           
##  [28] R6_2.5.1                fastmap_1.2.0           GenomeInfoDbData_1.2.12
##  [31] shiny_1.9.1             digest_0.6.37           colorspace_2.1-1       
##  [34] AnnotationDbi_1.66.0    Hmisc_5.1-3             RSQLite_2.3.7          
##  [37] labeling_0.4.3          fansi_1.0.6             httr_1.4.7             
##  [40] abind_1.4-8             compiler_4.4.1          bit64_4.5.2            
##  [43] withr_3.0.1             doParallel_1.0.17       htmlTable_2.4.3        
##  [46] backports_1.5.0         BiocParallel_1.38.0     DBI_1.2.3              
##  [49] ggstats_0.7.0           highr_0.11              DelayedArray_0.30.1    
##  [52] caTools_1.18.3          tools_4.4.1             foreign_0.8-87         
##  [55] httpuv_1.6.15           nnet_7.3-19             glue_1.8.0             
##  [58] promises_1.3.0          grid_4.4.1              checkmate_2.3.2        
##  [61] cluster_2.1.6           generics_0.1.3          gtable_0.3.5           
##  [64] preprocessCore_1.66.0   tidyr_1.3.1             hms_1.1.3              
##  [67] data.table_1.16.0       xml2_1.3.6              utf8_1.2.4             
##  [70] XVector_0.44.0          foreach_1.5.2           pillar_1.9.0           
##  [73] stringr_1.5.1           later_1.3.2             rJava_1.0-11           
##  [76] splines_4.4.1           lattice_0.22-6          survival_3.7-0         
##  [79] bit_4.5.0               tidyselect_1.2.1        GO.db_3.19.1           
##  [82] locfit_1.5-9.10         Biostrings_2.72.1       knitr_1.48             
##  [85] gridExtra_2.3           svglite_2.1.3           xfun_0.48              
##  [88] stringi_1.8.4           UCSC.utils_1.0.0        yaml_2.3.10            
##  [91] xlsxjars_0.6.1          evaluate_1.0.1          codetools_0.2-20       
##  [94] cli_3.6.3               rpart_4.1.23            xtable_1.8-4           
##  [97] systemfonts_1.1.0       munsell_0.5.1           jquerylib_0.1.4        
## [100] Rcpp_1.0.13             png_0.1-8               parallel_4.4.1         
## [103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-9           
## [106] viridisLite_0.4.2       scales_1.3.0            purrr_1.0.2            
## [109] crayon_1.5.3            rlang_1.1.4             KEGGREST_1.44.1

END of report