Mitch Report

date generated: 2026-06-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	crp_eos_adj	crp_pod1_adj
5_8S_rRNA	-2.4785778	0.1666742
A1BG	-1.7542512	-1.0533790
A1BG-AS1	-1.0734376	-0.2260155
A1CF	0.5521423	1.1773563
A2M	1.6603822	1.7932114
A2M-AS1	1.3818491	0.7455571

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	21129
duplicated_genes_present	0
num_profile_genes_in_sets	8679
num_profile_genes_not_in_sets	12450
profile_pearson_correl	0.31904
profile_spearman_correl	0.32275

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1199
num_genesets_included	1526

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 766

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_eos_adj	s.crp_pod1_adj	p.crp_eos_adj	p.crp_pod1_adj
Formation of a pool of free 40S subunits	100	2.98e-59	5.20e-57	1.080	-0.8400	-0.685	5.84e-48	1.90e-32
Peptide chain elongation	88	4.37e-52	5.59e-50	1.080	-0.8400	-0.683	1.98e-42	1.52e-28
Eukaryotic Translation Elongation	93	1.15e-53	1.70e-51	1.070	-0.8320	-0.671	6.61e-44	4.36e-29
Viral mRNA Translation	88	7.35e-50	7.43e-48	1.060	-0.8290	-0.657	2.53e-41	1.44e-26
SARS-CoV-1 modulates host translation machinery	36	2.16e-20	6.79e-19	1.050	-0.8160	-0.656	2.20e-17	9.46e-12
L13a-mediated translational silencing of Ceruloplasmin expression	110	9.95e-61	2.12e-58	1.040	-0.8240	-0.642	1.25e-50	2.41e-31
Selenocysteine synthesis	92	2.17e-50	2.61e-48	1.040	-0.8020	-0.666	1.72e-40	2.22e-28
Eukaryotic Translation Termination	92	3.46e-50	3.87e-48	1.040	-0.8070	-0.654	5.21e-41	1.89e-27
Formation of the ternary complex, and subsequently, the 43S complex	51	6.46e-28	2.70e-26	1.030	-0.8100	-0.643	1.33e-23	1.88e-15
GTP hydrolysis and joining of the 60S ribosomal subunit	111	4.31e-60	8.28e-58	1.030	-0.8190	-0.630	1.55e-50	1.75e-30
Cap-dependent Translation Initiation	118	5.15e-63	1.24e-60	1.030	-0.8140	-0.626	6.42e-53	6.44e-32
Eukaryotic Translation Initiation	118	5.15e-63	1.24e-60	1.030	-0.8140	-0.626	6.42e-53	6.44e-32
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	1.07e-49	1.02e-47	1.020	-0.8000	-0.636	4.32e-41	1.29e-26
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	6.62e-30	3.03e-28	0.993	-0.7930	-0.597	5.06e-26	2.03e-15
Translation initiation complex formation	58	4.28e-29	1.87e-27	0.987	-0.7900	-0.592	2.04e-25	6.16e-15
Mitochondrial translation initiation	90	7.91e-45	6.33e-43	0.984	-0.8040	-0.568	8.28e-40	1.22e-20
SRP-dependent cotranslational protein targeting to membrane	111	7.34e-55	1.18e-52	0.981	-0.8030	-0.564	1.40e-48	8.83e-25
Ribosomal scanning and start codon recognition	58	1.26e-28	5.39e-27	0.977	-0.7880	-0.578	2.58e-25	2.55e-14
Mitochondrial translation elongation	90	2.13e-43	1.46e-41	0.968	-0.7900	-0.559	1.48e-38	4.76e-20
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	6.09e-47	5.08e-45	0.961	-0.7620	-0.586	1.06e-39	3.63e-24
Mitochondrial translation termination	90	3.18e-42	2.03e-40	0.954	-0.7800	-0.550	1.34e-37	1.84e-19
Mitochondrial translation	96	2.25e-44	1.73e-42	0.948	-0.7730	-0.549	2.75e-39	1.26e-20
Formation of xylulose-5-phosphate	5	6.62e-03	2.00e-02	0.937	-0.6000	-0.720	2.02e-02	5.30e-03
SARS-CoV-2 modulates host translation machinery	49	3.80e-21	1.26e-19	0.912	-0.7270	-0.551	1.27e-18	2.47e-11
Formation of ATP by chemiosmotic coupling	20	3.72e-10	4.26e-09	0.902	-0.8500	-0.300	4.51e-11	2.00e-02
Selenoamino acid metabolism	115	2.30e-47	2.11e-45	0.901	-0.7100	-0.555	1.16e-39	7.23e-25
Complex III assembly	23	3.07e-10	3.53e-09	0.896	-0.7580	-0.477	3.03e-10	7.53e-05
Response to metal ions	6	3.76e-05	2.15e-04	0.891	-0.4400	0.775	6.21e-02	1.01e-03
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	1.08e-02	3.07e-02	0.891	-0.6790	-0.576	8.54e-03	2.57e-02
Modulation by Mtb of host immune system	7	7.78e-04	3.25e-03	0.886	-0.8230	-0.329	1.62e-04	1.31e-01
G2/M DNA replication checkpoint	5	1.91e-04	9.15e-04	0.882	-0.5460	0.693	3.44e-02	7.28e-03
Translation	293	0.00e+00	0.00e+00	0.882	-0.7280	-0.496	0.00e+00	1.29e-48
CD163 mediating an anti-inflammatory response	8	4.51e-05	2.51e-04	0.874	0.0296	0.873	8.85e-01	1.88e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	4.02e-44	2.86e-42	0.874	-0.6860	-0.541	8.20e-37	1.58e-23
Nonsense-Mediated Decay (NMD)	114	4.02e-44	2.86e-42	0.874	-0.6860	-0.541	8.20e-37	1.58e-23
Regulation of NFE2L2 gene expression	8	9.90e-04	4.02e-03	0.873	0.6420	0.591	1.67e-03	3.77e-03
Phosphate bond hydrolysis by NUDT proteins	7	1.87e-03	6.87e-03	0.863	-0.7460	-0.435	6.32e-04	4.65e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.55e-02	4.06e-02	0.857	-0.6240	-0.587	1.57e-02	2.30e-02
Major pathway of rRNA processing in the nucleolus and cytosol	179	2.55e-65	8.16e-63	0.851	-0.6710	-0.523	2.52e-54	1.19e-33
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.49e-03	8.87e-03	0.844	0.2190	0.815	3.52e-01	5.46e-04
rRNA processing in the nucleus and cytosol	189	1.37e-67	5.26e-65	0.843	-0.6630	-0.520	6.04e-56	4.69e-35
Inhibition of Signaling by Overexpressed EGFR	5	1.24e-02	3.40e-02	0.839	0.3680	0.754	1.54e-01	3.51e-03
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	1.24e-02	3.40e-02	0.839	0.3680	0.754	1.54e-01	3.51e-03
rRNA processing	213	1.54e-73	9.87e-71	0.825	-0.6660	-0.487	2.46e-63	1.28e-34
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	9.44e-03	2.72e-02	0.825	-0.6340	-0.527	7.16e-03	2.53e-02
Synthesis of diphthamide-EEF2	8	2.03e-03	7.37e-03	0.823	-0.5220	-0.636	1.05e-02	1.83e-03
Processing of SMDT1	15	7.08e-06	4.47e-05	0.823	-0.6760	-0.470	5.83e-06	1.64e-03
Arachidonate production from DAG	5	1.53e-02	4.03e-02	0.814	-0.7380	-0.342	4.25e-03	1.85e-01
rRNA modification in the mitochondrion	8	2.69e-03	9.39e-03	0.801	-0.4830	-0.639	1.81e-02	1.76e-03
Mitochondrial calcium ion transport	22	3.95e-08	3.60e-07	0.800	-0.6960	-0.395	1.57e-08	1.35e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_eos_adj	s.crp_pod1_adj	p.crp_eos_adj	p.crp_pod1_adj
Formation of a pool of free 40S subunits	100	2.98e-59	5.20e-57	1.08000	-8.40e-01	-6.85e-01	5.84e-48	1.90e-32
Peptide chain elongation	88	4.37e-52	5.59e-50	1.08000	-8.40e-01	-6.83e-01	1.98e-42	1.52e-28
Eukaryotic Translation Elongation	93	1.15e-53	1.70e-51	1.07000	-8.32e-01	-6.71e-01	6.61e-44	4.36e-29
Viral mRNA Translation	88	7.35e-50	7.43e-48	1.06000	-8.29e-01	-6.57e-01	2.53e-41	1.44e-26
SARS-CoV-1 modulates host translation machinery	36	2.16e-20	6.79e-19	1.05000	-8.16e-01	-6.56e-01	2.20e-17	9.46e-12
L13a-mediated translational silencing of Ceruloplasmin expression	110	9.95e-61	2.12e-58	1.04000	-8.24e-01	-6.42e-01	1.25e-50	2.41e-31
Selenocysteine synthesis	92	2.17e-50	2.61e-48	1.04000	-8.02e-01	-6.66e-01	1.72e-40	2.22e-28
Eukaryotic Translation Termination	92	3.46e-50	3.87e-48	1.04000	-8.07e-01	-6.54e-01	5.21e-41	1.89e-27
Formation of the ternary complex, and subsequently, the 43S complex	51	6.46e-28	2.70e-26	1.03000	-8.10e-01	-6.43e-01	1.33e-23	1.88e-15
GTP hydrolysis and joining of the 60S ribosomal subunit	111	4.31e-60	8.28e-58	1.03000	-8.19e-01	-6.30e-01	1.55e-50	1.75e-30
Cap-dependent Translation Initiation	118	5.15e-63	1.24e-60	1.03000	-8.14e-01	-6.26e-01	6.42e-53	6.44e-32
Eukaryotic Translation Initiation	118	5.15e-63	1.24e-60	1.03000	-8.14e-01	-6.26e-01	6.42e-53	6.44e-32
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	1.07e-49	1.02e-47	1.02000	-8.00e-01	-6.36e-01	4.32e-41	1.29e-26
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	6.62e-30	3.03e-28	0.99300	-7.93e-01	-5.97e-01	5.06e-26	2.03e-15
Translation initiation complex formation	58	4.28e-29	1.87e-27	0.98700	-7.90e-01	-5.92e-01	2.04e-25	6.16e-15
Mitochondrial translation initiation	90	7.91e-45	6.33e-43	0.98400	-8.04e-01	-5.68e-01	8.28e-40	1.22e-20
SRP-dependent cotranslational protein targeting to membrane	111	7.34e-55	1.18e-52	0.98100	-8.03e-01	-5.64e-01	1.40e-48	8.83e-25
Ribosomal scanning and start codon recognition	58	1.26e-28	5.39e-27	0.97700	-7.88e-01	-5.78e-01	2.58e-25	2.55e-14
Mitochondrial translation elongation	90	2.13e-43	1.46e-41	0.96800	-7.90e-01	-5.59e-01	1.48e-38	4.76e-20
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	6.09e-47	5.08e-45	0.96100	-7.62e-01	-5.86e-01	1.06e-39	3.63e-24
Mitochondrial translation termination	90	3.18e-42	2.03e-40	0.95400	-7.80e-01	-5.50e-01	1.34e-37	1.84e-19
Mitochondrial translation	96	2.25e-44	1.73e-42	0.94800	-7.73e-01	-5.49e-01	2.75e-39	1.26e-20
Formation of xylulose-5-phosphate	5	6.62e-03	2.00e-02	0.93700	-6.00e-01	-7.20e-01	2.02e-02	5.30e-03
SARS-CoV-2 modulates host translation machinery	49	3.80e-21	1.26e-19	0.91200	-7.27e-01	-5.51e-01	1.27e-18	2.47e-11
Formation of ATP by chemiosmotic coupling	20	3.72e-10	4.26e-09	0.90200	-8.50e-01	-3.00e-01	4.51e-11	2.00e-02
Selenoamino acid metabolism	115	2.30e-47	2.11e-45	0.90100	-7.10e-01	-5.55e-01	1.16e-39	7.23e-25
Complex III assembly	23	3.07e-10	3.53e-09	0.89600	-7.58e-01	-4.77e-01	3.03e-10	7.53e-05
Response to metal ions	6	3.76e-05	2.15e-04	0.89100	-4.40e-01	7.75e-01	6.21e-02	1.01e-03
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	1.08e-02	3.07e-02	0.89100	-6.79e-01	-5.76e-01	8.54e-03	2.57e-02
Modulation by Mtb of host immune system	7	7.78e-04	3.25e-03	0.88600	-8.23e-01	-3.29e-01	1.62e-04	1.31e-01
G2/M DNA replication checkpoint	5	1.91e-04	9.15e-04	0.88200	-5.46e-01	6.93e-01	3.44e-02	7.28e-03
Translation	293	2.19e-116	4.21e-113	0.88200	-7.28e-01	-4.96e-01	3.98e-103	1.29e-48
CD163 mediating an anti-inflammatory response	8	4.51e-05	2.51e-04	0.87400	2.96e-02	8.73e-01	8.85e-01	1.88e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	4.02e-44	2.86e-42	0.87400	-6.86e-01	-5.41e-01	8.20e-37	1.58e-23
Nonsense-Mediated Decay (NMD)	114	4.02e-44	2.86e-42	0.87400	-6.86e-01	-5.41e-01	8.20e-37	1.58e-23
Regulation of NFE2L2 gene expression	8	9.90e-04	4.02e-03	0.87300	6.42e-01	5.91e-01	1.67e-03	3.77e-03
Phosphate bond hydrolysis by NUDT proteins	7	1.87e-03	6.87e-03	0.86300	-7.46e-01	-4.35e-01	6.32e-04	4.65e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	1.55e-02	4.06e-02	0.85700	-6.24e-01	-5.87e-01	1.57e-02	2.30e-02
Major pathway of rRNA processing in the nucleolus and cytosol	179	2.55e-65	8.16e-63	0.85100	-6.71e-01	-5.23e-01	2.52e-54	1.19e-33
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	2.49e-03	8.87e-03	0.84400	2.19e-01	8.15e-01	3.52e-01	5.46e-04
rRNA processing in the nucleus and cytosol	189	1.37e-67	5.26e-65	0.84300	-6.63e-01	-5.20e-01	6.04e-56	4.69e-35
Inhibition of Signaling by Overexpressed EGFR	5	1.24e-02	3.40e-02	0.83900	3.68e-01	7.54e-01	1.54e-01	3.51e-03
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	1.24e-02	3.40e-02	0.83900	3.68e-01	7.54e-01	1.54e-01	3.51e-03
rRNA processing	213	1.54e-73	9.87e-71	0.82500	-6.66e-01	-4.87e-01	2.46e-63	1.28e-34
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	9.44e-03	2.72e-02	0.82500	-6.34e-01	-5.27e-01	7.16e-03	2.53e-02
Synthesis of diphthamide-EEF2	8	2.03e-03	7.37e-03	0.82300	-5.22e-01	-6.36e-01	1.05e-02	1.83e-03
Processing of SMDT1	15	7.08e-06	4.47e-05	0.82300	-6.76e-01	-4.70e-01	5.83e-06	1.64e-03
Arachidonate production from DAG	5	1.53e-02	4.03e-02	0.81400	-7.38e-01	-3.42e-01	4.25e-03	1.85e-01
rRNA modification in the mitochondrion	8	2.69e-03	9.39e-03	0.80100	-4.83e-01	-6.39e-01	1.81e-02	1.76e-03
Mitochondrial calcium ion transport	22	3.95e-08	3.60e-07	0.80000	-6.96e-01	-3.95e-01	1.57e-08	1.35e-03
Influenza Viral RNA Transcription and Replication	135	2.35e-43	1.56e-41	0.79900	-6.08e-01	-5.18e-01	2.24e-34	2.41e-25
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	4.75e-03	1.52e-02	0.79500	-6.91e-01	-3.93e-01	1.55e-03	7.15e-02
EGFR interacts with phospholipase C-gamma	6	1.29e-02	3.51e-02	0.78500	4.31e-01	6.56e-01	6.74e-02	5.42e-03
Mitochondrial protein import	63	2.52e-20	7.82e-19	0.78500	-6.40e-01	-4.53e-01	1.37e-18	4.88e-10
Post-transcriptional silencing by small RNAs	7	4.35e-03	1.41e-02	0.78200	7.13e-01	3.20e-01	1.08e-03	1.42e-01
Defective binding of VWF variant to GPIb:IX:V	5	1.79e-03	6.61e-03	0.77900	-7.08e-01	3.25e-01	6.11e-03	2.08e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	5	1.79e-03	6.61e-03	0.77900	-7.08e-01	3.25e-01	6.11e-03	2.08e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	4.78e-04	2.14e-03	0.77800	-6.10e-01	-4.83e-01	4.58e-04	5.54e-03
Defective GALNT3 causes HFTC	8	4.11e-03	1.34e-02	0.77700	5.12e-01	5.84e-01	1.21e-02	4.22e-03
SUMO is conjugated to E1 (UBA2:SAE1)	5	1.67e-02	4.30e-02	0.77700	-7.39e-01	-2.39e-01	4.22e-03	3.54e-01
Regulation of expression of SLITs and ROBOs	149	3.06e-47	2.67e-45	0.77600	-6.65e-01	-3.99e-01	8.23e-45	4.22e-17
Sulfide oxidation to sulfate	5	3.38e-02	7.74e-02	0.76900	-6.01e-01	-4.80e-01	2.00e-02	6.32e-02
MET activates PI3K/AKT signaling	5	3.52e-02	7.96e-02	0.76500	5.90e-01	4.87e-01	2.24e-02	5.91e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	1.75e-02	4.49e-02	0.76300	-6.15e-01	-4.51e-01	9.06e-03	5.60e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	3.73e-02	8.36e-02	0.76000	-5.67e-01	-5.07e-01	2.82e-02	4.95e-02
Complex I biogenesis	66	1.73e-20	5.54e-19	0.74900	-6.63e-01	-3.48e-01	1.06e-20	1.02e-06
NFE2L2 regulates pentose phosphate pathway genes	8	2.67e-03	9.34e-03	0.74700	2.54e-01	7.02e-01	2.13e-01	5.83e-04
Cristae formation	33	2.80e-11	3.63e-10	0.74100	-7.01e-01	-2.40e-01	3.17e-12	1.71e-02
SLBP independent Processing of Histone Pre-mRNAs	10	1.86e-03	6.84e-03	0.74000	-5.78e-01	-4.63e-01	1.56e-03	1.12e-02
Influenza Infection	154	4.25e-42	2.63e-40	0.73800	-5.59e-01	-4.81e-01	3.97e-33	5.57e-25
Erythrocytes take up oxygen and release carbon dioxide	7	1.19e-02	3.31e-02	0.73100	3.96e-01	6.15e-01	6.98e-02	4.83e-03
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	1.02e-07	8.53e-07	0.72400	-7.23e-01	-3.89e-02	4.80e-08	7.69e-01
Recycling of eIF2:GDP	8	5.43e-03	1.71e-02	0.72400	-6.49e-01	-3.21e-01	1.48e-03	1.16e-01
Signaling by RNF43 mutants	7	1.61e-02	4.18e-02	0.71800	5.58e-01	4.51e-01	1.05e-02	3.90e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	5	5.39e-02	1.09e-01	0.71700	5.30e-01	4.83e-01	4.01e-02	6.14e-02
Respiratory electron transport	149	2.81e-41	1.69e-39	0.71600	-6.32e-01	-3.37e-01	1.40e-40	1.20e-12
Cellular response to starvation	148	3.18e-39	1.80e-37	0.71300	-5.98e-01	-3.88e-01	2.52e-36	3.41e-16
rRNA processing in the mitochondrion	24	6.99e-08	6.05e-07	0.71100	-6.77e-01	-2.20e-01	9.44e-09	6.23e-02
HDMs demethylate histones	22	1.48e-06	1.04e-05	0.71100	6.17e-01	3.53e-01	5.44e-07	4.13e-03
Interleukin-21 signaling	9	3.85e-03	1.28e-02	0.70700	6.30e-01	3.22e-01	1.07e-03	9.47e-02
Maturation of TCA enzymes and regulation of TCA cycle	20	5.32e-06	3.46e-05	0.70500	-6.20e-01	-3.36e-01	1.58e-06	9.19e-03
RNA Polymerase I Promoter Opening	17	5.28e-08	4.67e-07	0.70500	-6.73e-01	2.10e-01	1.54e-06	1.33e-01
Cation-coupled Chloride cotransporters	6	2.93e-02	6.91e-02	0.70200	6.00e-01	3.65e-01	1.10e-02	1.22e-01
Acetylcholine binding and downstream events	5	4.37e-02	9.36e-02	0.70100	2.83e-01	6.41e-01	2.73e-01	1.30e-02
Postsynaptic nicotinic acetylcholine receptors	5	4.37e-02	9.36e-02	0.70100	2.83e-01	6.41e-01	2.73e-01	1.30e-02
Packaging Of Telomere Ends	18	1.09e-07	9.09e-07	0.70100	-6.95e-01	9.15e-02	3.32e-07	5.01e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	3.36e-02	7.72e-02	0.70100	-4.27e-01	-5.56e-01	7.02e-02	1.84e-02
tRNA modification in the mitochondrion	9	5.59e-03	1.75e-02	0.69800	-5.88e-01	-3.77e-01	2.26e-03	5.05e-02
rRNA modification in the nucleus and cytosol	59	5.31e-15	1.04e-13	0.69500	-5.55e-01	-4.19e-01	1.68e-13	2.55e-08
Methionine salvage pathway	6	3.80e-02	8.48e-02	0.69300	-4.77e-01	-5.03e-01	4.30e-02	3.29e-02
Mitochondrial RNA degradation	25	1.63e-08	1.56e-07	0.68700	-6.80e-01	-9.98e-02	3.91e-09	3.88e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	3.42e-02	7.82e-02	0.68300	3.41e-01	5.91e-01	1.48e-01	1.21e-02
RNA Polymerase III Chain Elongation	18	5.46e-05	2.97e-04	0.68300	-5.63e-01	-3.86e-01	3.53e-05	4.54e-03
Cleavage of the damaged purine	21	1.56e-07	1.26e-06	0.67600	-6.75e-01	-2.48e-02	8.36e-08	8.44e-01
Depurination	21	1.56e-07	1.26e-06	0.67600	-6.75e-01	-2.48e-02	8.36e-08	8.44e-01
Recognition and association of DNA glycosylase with site containing an affected purine	21	1.56e-07	1.26e-06	0.67600	-6.75e-01	-2.48e-02	8.36e-08	8.44e-01
G2 Phase	5	6.49e-03	1.97e-02	0.67500	-5.04e-01	4.49e-01	5.09e-02	8.22e-02
Regulation of NPAS4 gene expression	11	1.89e-03	6.91e-03	0.67200	6.10e-01	2.81e-01	4.57e-04	1.07e-01
Mitochondrial iron-sulfur cluster biogenesis	13	7.79e-04	3.25e-03	0.67100	-5.91e-01	-3.18e-01	2.25e-04	4.69e-02
Maturation of spike protein 9683686	5	7.14e-02	1.36e-01	0.66900	-5.59e-01	-3.68e-01	3.04e-02	1.54e-01
Type I hemidesmosome assembly	8	1.43e-02	3.81e-02	0.66900	3.55e-01	5.67e-01	8.17e-02	5.52e-03
Cellular response to mitochondrial stress	9	5.72e-03	1.78e-02	0.66600	-6.16e-01	-2.53e-01	1.38e-03	1.88e-01
Regulation of CDH11 mRNA translation by microRNAs	8	8.30e-03	2.43e-02	0.66300	6.32e-01	2.02e-01	1.96e-03	3.23e-01
Regulation of NPAS4 mRNA translation	8	8.30e-03	2.43e-02	0.66300	6.32e-01	2.02e-01	1.96e-03	3.23e-01
Replacement of protamines by nucleosomes in the male pronucleus	12	2.10e-05	1.25e-04	0.66200	-6.13e-01	2.48e-01	2.35e-04	1.36e-01
Displacement of DNA glycosylase by APEX1	9	1.15e-02	3.22e-02	0.66100	-4.84e-01	-4.51e-01	1.19e-02	1.92e-02
Mitochondrial protein degradation	96	1.08e-22	3.92e-21	0.65900	-5.76e-01	-3.21e-01	1.67e-22	5.28e-08
Vitamin B1 (thiamin) metabolism	5	8.53e-02	1.56e-01	0.65500	-4.05e-01	-5.15e-01	1.17e-01	4.63e-02
Purine ribonucleoside monophosphate biosynthesis	9	1.25e-02	3.42e-02	0.65200	-5.04e-01	-4.14e-01	8.79e-03	3.15e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	3.84e-04	1.76e-03	0.65200	3.00e-01	5.79e-01	4.39e-02	1.03e-04
tRNA processing in the mitochondrion	24	4.72e-07	3.56e-06	0.64400	-6.31e-01	-1.29e-01	8.51e-08	2.73e-01
PDH complex synthesizes acetyl-CoA from PYR	5	5.51e-02	1.11e-01	0.64200	-6.21e-01	-1.66e-01	1.62e-02	5.21e-01
Citric acid cycle (TCA cycle)	34	1.45e-08	1.40e-07	0.64100	-5.92e-01	-2.46e-01	2.24e-09	1.30e-02
Malate-aspartate shuttle	8	2.19e-02	5.41e-02	0.64100	-5.21e-01	-3.73e-01	1.07e-02	6.78e-02
DNA methylation	18	1.72e-07	1.38e-06	0.64100	-5.72e-01	2.89e-01	2.66e-05	3.39e-02
APOBEC3G mediated resistance to HIV-1 infection	5	9.12e-02	1.64e-01	0.63900	-3.55e-01	-5.31e-01	1.69e-01	3.99e-02
Abacavir ADME	5	8.55e-02	1.56e-01	0.63700	5.55e-01	3.14e-01	3.17e-02	2.24e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	2.57e-03	9.09e-03	0.63600	-4.46e-01	-4.54e-01	5.39e-03	4.60e-03
Alpha-oxidation of phytanate	6	6.30e-02	1.23e-01	0.63100	-5.09e-01	-3.73e-01	3.09e-02	1.14e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	7.37e-08	6.32e-07	0.63000	-5.79e-01	2.50e-01	7.42e-06	5.32e-02
GAB1 signalosome	14	1.10e-03	4.37e-03	0.62900	2.92e-01	5.57e-01	5.89e-02	3.06e-04
POLB-Dependent Long Patch Base Excision Repair	8	1.83e-02	4.66e-02	0.62800	-2.61e-01	-5.72e-01	2.02e-01	5.11e-03
Defective GALNT12 causes CRCS1	8	2.83e-02	6.70e-02	0.62700	4.42e-01	4.44e-01	3.03e-02	2.95e-02
Protein methylation	15	1.04e-03	4.18e-03	0.62600	-5.16e-01	-3.54e-01	5.41e-04	1.75e-02
Translesion synthesis by POLI	17	5.45e-04	2.37e-03	0.62400	-4.48e-01	-4.35e-01	1.38e-03	1.90e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	1.93e-12	2.80e-11	0.62400	-6.22e-01	5.86e-02	1.80e-11	5.27e-01
p53-Independent DNA Damage Response	39	1.93e-12	2.80e-11	0.62400	-6.22e-01	5.86e-02	1.80e-11	5.27e-01
p53-Independent G1/S DNA damage checkpoint	39	1.93e-12	2.80e-11	0.62400	-6.22e-01	5.86e-02	1.80e-11	5.27e-01
Fructose metabolism	7	2.87e-02	6.77e-02	0.62300	-2.27e-01	-5.80e-01	2.98e-01	7.85e-03
PI3K events in ERBB4 signaling	6	6.15e-02	1.21e-01	0.61900	5.40e-01	3.01e-01	2.19e-02	2.01e-01
Complex IV assembly	45	8.00e-10	8.78e-09	0.61700	-5.44e-01	-2.90e-01	2.63e-10	7.71e-04
Ethanol oxidation	6	5.34e-02	1.09e-01	0.61600	-2.38e-01	-5.68e-01	3.13e-01	1.60e-02
Vif-mediated degradation of APOBEC3G	41	3.97e-12	5.54e-11	0.61400	-6.14e-01	1.39e-02	9.98e-12	8.78e-01
Aerobic respiration and respiratory electron transport	245	3.63e-50	3.87e-48	0.61400	-5.49e-01	-2.74e-01	9.35e-50	1.36e-13
PINK1-PRKN Mediated Mitophagy	31	4.39e-07	3.32e-06	0.61200	-5.55e-01	-2.58e-01	8.78e-08	1.27e-02
Sodium/Proton exchangers	7	5.02e-02	1.04e-01	0.61200	3.97e-01	4.66e-01	6.87e-02	3.28e-02
SIRT1 negatively regulates rRNA expression	22	1.17e-06	8.34e-06	0.61200	-6.12e-01	-7.88e-03	6.79e-07	9.49e-01
Protein repair	6	7.48e-03	2.22e-02	0.60900	-4.72e-01	3.84e-01	4.52e-02	1.03e-01
GDP-fucose biosynthesis	6	7.94e-02	1.47e-01	0.60700	-4.74e-01	-3.79e-01	4.43e-02	1.08e-01
Vpu mediated degradation of CD4	39	3.57e-11	4.58e-10	0.60600	-6.06e-01	2.29e-03	5.51e-11	9.80e-01
Cohesin Loading onto Chromatin	10	1.54e-02	4.04e-02	0.60500	4.61e-01	3.92e-01	1.16e-02	3.19e-02
NFE2L2 regulating tumorigenic genes	11	7.09e-03	2.12e-02	0.60400	2.76e-01	5.37e-01	1.13e-01	2.04e-03
Translesion synthesis by REV1	16	1.32e-03	5.11e-03	0.60400	-4.49e-01	-4.03e-01	1.86e-03	5.24e-03
Release of apoptotic factors from the mitochondria	6	5.81e-02	1.16e-01	0.60300	-5.61e-01	-2.20e-01	1.73e-02	3.51e-01
Folding of actin by CCT/TriC	10	4.05e-03	1.33e-02	0.60200	-5.96e-01	-8.64e-02	1.10e-03	6.36e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	4.99e-11	6.19e-10	0.60100	-5.99e-01	5.61e-02	2.90e-10	5.55e-01
TGFBR3 expression	20	3.60e-05	2.06e-04	0.60100	5.83e-01	1.48e-01	6.42e-06	2.52e-01
p130Cas linkage to MAPK signaling for integrins	11	4.33e-04	1.95e-03	0.60100	-5.80e-01	1.58e-01	8.68e-04	3.63e-01
STAT5 activation downstream of FLT3 ITD mutants	9	7.99e-03	2.36e-02	0.60100	1.06e-01	5.92e-01	5.81e-01	2.12e-03
DNA replication initiation	8	3.78e-02	8.44e-02	0.60100	-4.31e-01	-4.19e-01	3.48e-02	4.02e-02
Proteasome assembly	50	9.62e-13	1.49e-11	0.60000	-5.95e-01	-7.68e-02	3.15e-13	3.48e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.83e-05	2.18e-04	0.60000	-5.00e-01	3.32e-01	1.80e-03	3.82e-02
Propionyl-CoA catabolism	5	1.16e-01	1.99e-01	0.60000	-3.09e-01	-5.14e-01	2.31e-01	4.66e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	6.14e-12	8.43e-11	0.60000	-5.98e-01	4.39e-02	3.41e-11	6.27e-01
CD22 mediated BCR regulation	57	6.48e-19	1.86e-17	0.59800	-5.52e-01	2.30e-01	5.50e-13	2.71e-03
Signaling by ROBO receptors	189	1.75e-36	8.86e-35	0.59800	-5.27e-01	-2.81e-01	5.48e-36	2.52e-11
RNA Polymerase III Transcription Termination	22	9.48e-05	4.88e-04	0.59700	-5.02e-01	-3.23e-01	4.56e-05	8.74e-03
Relaxin receptors	5	6.15e-02	1.21e-01	0.59500	5.54e-02	5.93e-01	8.30e-01	2.17e-02
Miscellaneous substrates	7	5.22e-02	1.07e-01	0.59300	5.09e-01	3.05e-01	1.96e-02	1.63e-01
Diseases of branched-chain amino acid catabolism	13	5.47e-03	1.72e-02	0.59300	-3.89e-01	-4.48e-01	1.52e-02	5.17e-03
Tandem pore domain potassium channels	5	1.35e-01	2.22e-01	0.59000	4.66e-01	3.63e-01	7.13e-02	1.60e-01
Inhibition of DNA recombination at telomere	33	1.78e-08	1.69e-07	0.59000	-5.86e-01	-6.50e-02	5.56e-09	5.18e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	6.15e-02	1.21e-01	0.58900	3.69e-01	4.60e-01	9.12e-02	3.51e-02
Regulation of gene expression by Hypoxia-inducible Factor	8	2.54e-02	6.12e-02	0.58900	2.04e-01	5.53e-01	3.18e-01	6.77e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	1.29e-02	3.51e-02	0.58900	5.32e-01	2.54e-01	3.59e-03	1.65e-01
Classical antibody-mediated complement activation	68	2.47e-21	8.31e-20	0.58900	-5.55e-01	1.96e-01	2.29e-15	5.14e-03
Defective HLCS causes multiple carboxylase deficiency	7	5.88e-02	1.17e-01	0.58800	-3.33e-01	-4.85e-01	1.27e-01	2.63e-02
GRB2 events in EGFR signaling	10	1.18e-02	3.28e-02	0.58800	2.29e-01	5.41e-01	2.09e-01	3.04e-03
RORA activates gene expression	18	5.65e-04	2.44e-03	0.58800	5.07e-01	2.96e-01	1.93e-04	2.94e-02
RHOT1 GTPase cycle	5	3.52e-02	7.96e-02	0.58500	-1.59e-01	5.63e-01	5.37e-01	2.93e-02
Zygotic genome activation (ZGA)	5	1.10e-01	1.92e-01	0.58400	5.40e-01	2.23e-01	3.65e-02	3.87e-01
Ubiquitin-dependent degradation of Cyclin D	39	7.60e-11	9.23e-10	0.58400	-5.82e-01	4.30e-02	3.06e-10	6.42e-01
Fatty acids	6	9.83e-02	1.74e-01	0.58400	4.27e-01	3.98e-01	7.03e-02	9.12e-02
Defects in biotin (Btn) metabolism	8	3.15e-02	7.31e-02	0.58300	-2.38e-01	-5.32e-01	2.44e-01	9.11e-03
Negative regulation of NOTCH4 signaling	44	4.01e-12	5.54e-11	0.58100	-5.79e-01	5.03e-02	2.97e-11	5.64e-01
Interaction between L1 and Ankyrins	25	4.22e-05	2.38e-04	0.58100	3.01e-01	4.97e-01	9.21e-03	1.70e-05
Regulation of ornithine decarboxylase (ODC)	38	5.54e-11	6.82e-10	0.58000	-5.72e-01	9.60e-02	1.06e-09	3.06e-01
Defective CFTR causes cystic fibrosis	47	3.53e-13	5.75e-12	0.57800	-5.72e-01	8.36e-02	1.17e-11	3.21e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	2.13e-05	1.26e-04	0.57800	-4.58e-01	-3.52e-01	2.71e-05	1.26e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	2.63e-11	3.44e-10	0.57800	-5.77e-01	3.50e-02	9.88e-11	6.95e-01
Base-Excision Repair, AP Site Formation	28	5.00e-07	3.75e-06	0.57600	-5.73e-01	-5.90e-02	1.54e-07	5.89e-01
Interleukin-6 signaling	10	2.14e-02	5.30e-02	0.57500	4.68e-01	3.33e-01	1.03e-02	6.81e-02
Hh mutants are degraded by ERAD	42	1.00e-11	1.36e-10	0.57500	-5.69e-01	8.17e-02	1.74e-10	3.59e-01
Regulation of Apoptosis	40	1.01e-10	1.19e-09	0.57400	-5.73e-01	3.92e-02	3.62e-10	6.68e-01
Defective C1GALT1C1 causes TNPS	9	3.31e-02	7.61e-02	0.57300	3.47e-01	4.56e-01	7.11e-02	1.79e-02
Regulation of Expression and Function of Type II Classical Cadherins	23	6.90e-05	3.63e-04	0.57200	5.23e-01	2.32e-01	1.41e-05	5.39e-02
Regulation of Homotypic Cell-Cell Adhesion	23	6.90e-05	3.63e-04	0.57200	5.23e-01	2.32e-01	1.41e-05	5.39e-02
Butyrophilin (BTN) family interactions	9	4.22e-03	1.37e-02	0.57200	1.00e-01	-5.63e-01	6.03e-01	3.46e-03
SCF(Skp2)-mediated degradation of p27/p21	50	7.36e-14	1.27e-12	0.57000	-5.62e-01	9.99e-02	6.27e-12	2.22e-01
Termination of O-glycan biosynthesis	15	2.58e-03	9.11e-03	0.57000	2.70e-01	5.02e-01	6.97e-02	7.64e-04
Scavenging by Class A Receptors	10	8.63e-04	3.53e-03	0.56900	-4.70e-01	3.21e-01	1.01e-02	7.84e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.58e-05	2.54e-04	0.56900	-4.40e-01	-3.60e-01	7.48e-05	1.20e-03
Scavenging of heme from plasma	69	1.17e-20	3.82e-19	0.56800	-5.24e-01	2.21e-01	5.14e-14	1.52e-03
Translesion synthesis by POLK	17	1.94e-03	7.09e-03	0.56800	-4.27e-01	-3.75e-01	2.32e-03	7.37e-03
Cleavage of the damaged pyrimidine	26	1.00e-06	7.20e-06	0.56800	-5.68e-01	-1.41e-02	5.35e-07	9.01e-01
Depyrimidination	26	1.00e-06	7.20e-06	0.56800	-5.68e-01	-1.41e-02	5.35e-07	9.01e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	26	1.00e-06	7.20e-06	0.56800	-5.68e-01	-1.41e-02	5.35e-07	9.01e-01
Synthesis of Dolichyl-phosphate	6	1.91e-02	4.83e-02	0.56800	-5.27e-01	2.11e-01	2.54e-02	3.70e-01
PCNA-Dependent Long Patch Base Excision Repair	21	4.69e-04	2.11e-03	0.56700	-4.22e-01	-3.78e-01	8.11e-04	2.70e-03
Protein localization	157	2.27e-26	9.07e-25	0.56600	-4.74e-01	-3.10e-01	1.10e-24	2.09e-11
Abortive elongation of HIV-1 transcript in the absence of Tat	23	1.34e-04	6.60e-04	0.56400	-4.95e-01	-2.69e-01	3.89e-05	2.56e-02
Mitotic Telophase/Cytokinesis	13	8.60e-03	2.50e-02	0.56300	3.39e-01	4.50e-01	3.45e-02	4.99e-03
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	1.12e-01	1.94e-01	0.56300	-4.47e-01	-3.41e-01	5.77e-02	1.48e-01
RNA Polymerase I Promoter Escape	45	1.11e-09	1.20e-08	0.56100	-5.49e-01	-1.14e-01	1.82e-10	1.85e-01
mRNA Splicing - Minor Pathway	50	1.56e-08	1.50e-07	0.56100	-4.35e-01	-3.54e-01	1.04e-07	1.47e-05
NRIF signals cell death from the nucleus	15	2.63e-03	9.22e-03	0.56100	-5.08e-01	-2.37e-01	6.54e-04	1.12e-01
APC/C:Cdc20 mediated degradation of Securin	55	1.14e-12	1.73e-11	0.56000	-5.58e-01	-4.00e-02	7.62e-13	6.08e-01
Removal of the Flap Intermediate	14	4.63e-03	1.49e-02	0.56000	-4.94e-01	-2.62e-01	1.36e-03	8.92e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	1.81e-14	3.35e-13	0.55900	-5.59e-01	7.86e-03	6.68e-14	9.16e-01
Defects of platelet adhesion to exposed collagen	6	2.00e-02	5.01e-02	0.55900	-5.07e-01	2.35e-01	3.14e-02	3.19e-01
SCF-beta-TrCP mediated degradation of Emi1	42	8.99e-11	1.07e-09	0.55900	-5.56e-01	4.83e-02	4.32e-10	5.88e-01
Autodegradation of the E3 ubiquitin ligase COP1	38	1.43e-09	1.52e-08	0.55800	-5.57e-01	2.53e-02	2.72e-09	7.87e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.21e-04	6.07e-04	0.55700	-4.54e-01	-3.23e-01	8.49e-05	5.23e-03
Adenylate cyclase activating pathway	8	4.12e-02	9.00e-02	0.55700	5.13e-01	2.18e-01	1.20e-02	2.87e-01
Metabolism of polyamines	46	1.57e-11	2.09e-10	0.55700	-5.55e-01	3.79e-02	7.08e-11	6.56e-01
Recycling of bile acids and salts	8	5.87e-02	1.17e-01	0.55600	4.35e-01	3.46e-01	3.32e-02	8.98e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	9.94e-11	1.18e-09	0.55500	-5.53e-01	5.42e-02	5.60e-10	5.44e-01
Signaling by FLT3 fusion proteins	18	1.85e-03	6.80e-03	0.55500	3.99e-01	3.86e-01	3.37e-03	4.56e-03
Hh mutants abrogate ligand secretion	43	4.75e-11	5.96e-10	0.55300	-5.49e-01	6.84e-02	4.56e-10	4.38e-01
Creation of C4 and C2 activators	70	3.42e-19	1.03e-17	0.55300	-5.27e-01	1.68e-01	2.34e-14	1.50e-02
RUNX1 regulates transcription of genes involved in WNT signaling	5	1.74e-01	2.69e-01	0.55200	4.28e-01	3.49e-01	9.75e-02	1.76e-01
Axonal growth inhibition (RHOA activation)	7	9.85e-03	2.82e-02	0.55100	-3.08e-01	4.57e-01	1.58e-01	3.64e-02
p75NTR regulates axonogenesis	7	9.85e-03	2.82e-02	0.55100	-3.08e-01	4.57e-01	1.58e-01	3.64e-02
Hedgehog ligand biogenesis	47	3.84e-12	5.42e-11	0.55000	-5.43e-01	8.97e-02	1.16e-10	2.87e-01
Fructose catabolism	5	1.58e-01	2.49e-01	0.54800	-2.54e-01	-4.85e-01	3.24e-01	6.02e-02
Phenylalanine metabolism	5	1.27e-01	2.12e-01	0.54700	-1.56e-01	-5.25e-01	5.47e-01	4.21e-02
Interleukin-7 signaling	21	7.10e-04	2.99e-03	0.54700	4.35e-01	3.32e-01	5.56e-04	8.40e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	63	5.29e-15	1.04e-13	0.54700	-5.45e-01	3.74e-02	6.77e-14	6.07e-01
Processive synthesis on the lagging strand	15	5.12e-03	1.62e-02	0.54500	-4.59e-01	-2.95e-01	2.10e-03	4.76e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	3.49e-04	1.62e-03	0.54500	-4.78e-01	-2.62e-01	1.04e-04	3.32e-02
Ubiquinol biosynthesis	13	1.16e-02	3.26e-02	0.54500	-4.34e-01	-3.30e-01	6.79e-03	3.91e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	59	5.69e-16	1.24e-14	0.54500	-5.15e-01	1.77e-01	7.49e-12	1.85e-02
Mitochondrial Fatty Acid Beta-Oxidation	36	4.60e-06	3.03e-05	0.54400	-4.36e-01	-3.24e-01	5.87e-06	7.62e-04
Regulation of CDH11 Expression and Function	22	2.16e-04	1.03e-03	0.54300	5.04e-01	2.03e-01	4.24e-05	9.91e-02
Pexophagy	10	3.50e-02	7.95e-02	0.54300	-3.99e-01	-3.69e-01	2.90e-02	4.32e-02
Regulation of IFNA/IFNB signaling	12	1.66e-02	4.28e-02	0.54200	3.14e-01	4.42e-01	5.95e-02	8.07e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	5.10e-14	9.16e-13	0.54100	-5.41e-01	2.15e-02	2.76e-13	7.71e-01
Protein hydroxylation	17	2.09e-03	7.55e-03	0.54100	-4.84e-01	-2.42e-01	5.54e-04	8.42e-02
Defective pyroptosis	27	2.27e-06	1.56e-05	0.54100	-5.40e-01	-1.29e-02	1.17e-06	9.07e-01
Cross-presentation of soluble exogenous antigens (endosomes)	35	3.47e-09	3.57e-08	0.54000	-5.26e-01	1.21e-01	7.09e-08	2.15e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	5.14e-15	1.03e-13	0.54000	-5.38e-01	4.61e-02	9.55e-14	5.23e-01
Processing and activation of SUMO	10	3.69e-02	8.30e-02	0.53900	-4.01e-01	-3.60e-01	2.82e-02	4.86e-02
Autodegradation of Cdh1 by Cdh1:APC/C	54	3.49e-11	4.50e-10	0.53700	-5.34e-01	-6.43e-02	1.15e-11	4.14e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	2.62e-03	9.20e-03	0.53600	-3.28e-01	-4.24e-01	1.60e-02	1.85e-03
Mitophagy	38	8.71e-07	6.34e-06	0.53500	-4.92e-01	-2.10e-01	1.52e-07	2.47e-02
Regulation of RUNX1 Expression and Activity	18	2.76e-03	9.55e-03	0.53500	4.14e-01	3.39e-01	2.37e-03	1.28e-02
NADE modulates death signalling	5	7.95e-02	1.48e-01	0.53400	-5.31e-01	5.17e-02	3.97e-02	8.41e-01
RNA Polymerase I Transcription Termination	30	3.91e-05	2.22e-04	0.53400	-4.53e-01	-2.82e-01	1.75e-05	7.50e-03
Signaling by FLT3 ITD and TKD mutants	15	3.94e-03	1.30e-02	0.53400	2.01e-01	4.94e-01	1.78e-01	9.18e-04
Netrin mediated repulsion signals	5	1.47e-01	2.36e-01	0.53300	1.69e-01	5.06e-01	5.14e-01	5.00e-02
Nectin/Necl trans heterodimerization	5	1.86e-01	2.82e-01	0.53200	4.50e-01	2.84e-01	8.11e-02	2.72e-01
Assembly of the ORC complex at the origin of replication	23	1.21e-05	7.44e-05	0.53200	-5.31e-01	3.40e-02	1.06e-05	7.78e-01
Protein lipoylation	10	4.06e-02	8.91e-02	0.53200	-3.73e-01	-3.79e-01	4.10e-02	3.82e-02
SHC1 events in EGFR signaling	11	2.04e-02	5.09e-02	0.53100	2.30e-01	4.79e-01	1.87e-01	5.92e-03
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.19e-04	6.01e-04	0.53100	-5.01e-01	-1.77e-01	2.15e-05	1.34e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	3.45e-04	1.61e-03	0.53000	-3.79e-01	-3.71e-01	1.04e-03	1.31e-03
ATF6 (ATF6-alpha) activates chaperone genes	10	2.19e-03	7.88e-03	0.53000	-4.36e-01	3.02e-01	1.70e-02	9.84e-02
NFE2L2 regulating MDR associated enzymes	8	6.30e-02	1.23e-01	0.52700	2.34e-01	4.72e-01	2.51e-01	2.07e-02
RUNX1 regulates estrogen receptor mediated transcription	6	1.42e-01	2.31e-01	0.52700	4.35e-01	2.98e-01	6.53e-02	2.06e-01
RHO GTPases activate IQGAPs	25	1.25e-06	8.86e-06	0.52500	-1.50e-01	5.03e-01	1.93e-01	1.31e-05
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.05e-03	4.19e-03	0.52400	-4.78e-01	2.16e-01	4.17e-03	1.94e-01
Interleukin receptor SHC signaling	23	6.51e-04	2.76e-03	0.52400	4.25e-01	3.07e-01	4.18e-04	1.08e-02
CDK-mediated phosphorylation and removal of Cdc6	60	9.91e-13	1.52e-11	0.52400	-5.24e-01	3.74e-03	2.21e-12	9.60e-01
Termination of translesion DNA synthesis	32	4.48e-05	2.51e-04	0.52300	-4.04e-01	-3.32e-01	7.50e-05	1.15e-03
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	6.98e-02	1.34e-01	0.52200	-1.40e-01	-5.03e-01	5.22e-01	2.12e-02
Regulation of CDH19 Expression and Function	5	2.00e-01	3.00e-01	0.52200	4.39e-01	2.82e-01	8.88e-02	2.76e-01
Regulation of CDH11 function	9	5.12e-02	1.06e-01	0.52200	4.55e-01	2.54e-01	1.80e-02	1.87e-01
Urea cycle	6	5.01e-02	1.04e-01	0.52000	-5.14e-01	8.22e-02	2.93e-02	7.27e-01
Binding and Uptake of Ligands by Scavenger Receptors	89	1.13e-22	4.01e-21	0.52000	-4.67e-01	2.30e-01	2.63e-14	1.80e-04
Mitochondrial tRNA aminoacylation	21	1.30e-03	5.03e-03	0.51900	-4.31e-01	-2.89e-01	6.21e-04	2.18e-02
Translesion Synthesis by POLH	18	4.08e-03	1.33e-02	0.51900	-3.55e-01	-3.79e-01	9.06e-03	5.43e-03
Biosynthesis of Lipoxins (LX)	6	6.32e-02	1.23e-01	0.51800	-1.91e-02	5.18e-01	9.35e-01	2.80e-02
Signal attenuation	9	6.95e-03	2.10e-02	0.51700	-2.06e-01	4.73e-01	2.84e-01	1.39e-02
Expression and translocation of olfactory receptors	49	1.48e-07	1.21e-06	0.51600	2.55e-01	4.48e-01	2.01e-03	5.72e-08
Resolution of Abasic Sites (AP sites)	38	1.07e-05	6.66e-05	0.51500	-3.53e-01	-3.76e-01	1.69e-04	6.04e-05
Base Excision Repair	56	8.93e-09	8.71e-08	0.51500	-4.63e-01	-2.26e-01	2.00e-09	3.46e-03
Stabilization of p53	43	7.04e-09	6.97e-08	0.51500	-5.15e-01	-1.21e-02	5.16e-09	8.91e-01
Orc1 removal from chromatin	58	4.01e-12	5.54e-11	0.51400	-5.14e-01	1.94e-02	1.29e-11	7.98e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	9.22e-02	1.65e-01	0.51400	8.20e-02	5.07e-01	7.28e-01	3.14e-02
Olfactory Signaling Pathway	54	2.71e-08	2.50e-07	0.51400	2.42e-01	4.53e-01	2.08e-03	8.38e-09
Lagging Strand Synthesis	20	2.54e-03	9.01e-03	0.51300	-3.75e-01	-3.50e-01	3.67e-03	6.71e-03
Glucuronidation	8	1.39e-02	3.75e-02	0.51200	-4.78e-01	1.83e-01	1.91e-02	3.69e-01
Initial triggering of complement	78	4.97e-18	1.33e-16	0.51200	-4.93e-01	1.37e-01	4.95e-14	3.61e-02
Interleukin-15 signaling	14	1.28e-02	3.49e-02	0.51100	4.36e-01	2.67e-01	4.76e-03	8.33e-02
Apoptosis induced DNA fragmentation	10	1.62e-02	4.19e-02	0.51100	-5.09e-01	-4.51e-02	5.30e-03	8.05e-01
Signaling by Erythropoietin	24	8.23e-04	3.41e-03	0.51100	3.64e-01	3.59e-01	2.01e-03	2.36e-03
Degradation of GLI2 by the proteasome	45	4.33e-10	4.84e-09	0.51100	-5.05e-01	7.77e-02	4.51e-09	3.67e-01
GLI3 is processed to GLI3R by the proteasome	45	4.33e-10	4.84e-09	0.51100	-5.05e-01	7.77e-02	4.51e-09	3.67e-01
Regulation of APC/C activators between G1/S and early anaphase	68	5.51e-14	9.71e-13	0.51100	-5.10e-01	2.42e-02	3.43e-13	7.30e-01
Glycosphingolipid biosynthesis	15	1.16e-02	3.26e-02	0.50900	3.96e-01	3.21e-01	7.97e-03	3.16e-02
Deposition of new CENPA-containing nucleosomes at the centromere	37	1.79e-07	1.41e-06	0.50900	-5.08e-01	-2.45e-02	8.61e-08	7.96e-01
Nucleosome assembly	37	1.79e-07	1.41e-06	0.50900	-5.08e-01	-2.45e-02	8.61e-08	7.96e-01
EGFR Transactivation by Gastrin	7	8.12e-02	1.50e-01	0.50900	1.41e-01	4.89e-01	5.19e-01	2.51e-02
Interleukin-10 signaling	35	3.52e-05	2.02e-04	0.50700	3.33e-01	3.83e-01	6.54e-04	8.78e-05
ATF6 (ATF6-alpha) activates chaperones	12	1.43e-03	5.40e-03	0.50700	-4.47e-01	2.40e-01	7.38e-03	1.50e-01
Eicosanoids	6	1.14e-01	1.96e-01	0.50700	1.28e-01	4.90e-01	5.88e-01	3.75e-02
Synthesis of UDP-N-acetyl-glucosamine	8	2.99e-02	7.00e-02	0.50700	1.72e-02	-5.06e-01	9.33e-01	1.32e-02
Degradation of DVL	43	2.10e-09	2.19e-08	0.50600	-5.02e-01	6.60e-02	1.21e-08	4.54e-01
RUNX3 regulates WNT signaling	8	7.52e-02	1.42e-01	0.50600	2.11e-01	4.60e-01	3.01e-01	2.44e-02
Synthesis of PI	5	1.86e-01	2.82e-01	0.50500	4.72e-01	1.80e-01	6.73e-02	4.86e-01
Dual Incision in GG-NER	41	4.74e-06	3.11e-05	0.50500	-4.19e-01	-2.83e-01	3.47e-06	1.74e-03
KSRP (KHSRP) binds and destabilizes mRNA	17	7.34e-03	2.19e-02	0.50500	-3.64e-01	-3.50e-01	9.28e-03	1.26e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.81e-02	8.48e-02	0.50500	-4.14e-01	-2.89e-01	1.75e-02	9.73e-02
Pentose phosphate pathway	13	1.41e-03	5.35e-03	0.50400	-4.81e-01	1.53e-01	2.69e-03	3.41e-01
Phosphorylation of Emi1	6	3.94e-02	8.66e-02	0.50200	-2.49e-01	4.36e-01	2.92e-01	6.43e-02
Metabolism of RNA	717	9.56e-91	9.18e-88	0.50200	-4.19e-01	-2.76e-01	5.16e-82	2.43e-36
Cytosolic iron-sulfur cluster assembly	13	2.44e-02	5.92e-02	0.50100	-3.73e-01	-3.35e-01	2.00e-02	3.62e-02
Assembly of the pre-replicative complex	87	5.56e-16	1.23e-14	0.50100	-5.00e-01	-2.90e-02	6.96e-16	6.40e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	1.91e-11	2.51e-10	0.50100	-5.00e-01	-2.78e-02	1.36e-11	7.07e-01
Class I peroxisomal membrane protein import	20	3.38e-03	1.14e-02	0.50100	-3.55e-01	-3.53e-01	5.94e-03	6.24e-03
tRNA modification in the nucleus and cytosol	43	4.11e-06	2.73e-05	0.50000	-4.00e-01	-3.00e-01	5.62e-06	6.69e-04
Recognition of DNA damage by PCNA-containing replication complex	30	1.44e-04	7.06e-04	0.50000	-4.20e-01	-2.70e-01	6.77e-05	1.04e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	8.11e-03	2.39e-02	0.49900	-4.79e-01	-1.41e-01	1.92e-03	3.63e-01
Alternative complement activation	5	2.44e-01	3.48e-01	0.49900	-3.45e-01	-3.61e-01	1.82e-01	1.63e-01
Metabolism of amino acids and derivatives	303	3.12e-40	1.82e-38	0.49900	-4.38e-01	-2.38e-01	2.16e-39	9.52e-13
Integration of provirus	9	7.05e-02	1.34e-01	0.49800	-2.65e-01	-4.22e-01	1.69e-01	2.83e-02
G1/S DNA Damage Checkpoints	54	6.15e-11	7.52e-10	0.49800	-4.96e-01	3.96e-02	2.79e-10	6.15e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	4.56e-02	9.72e-02	0.49800	3.57e-01	3.46e-01	4.03e-02	4.66e-02
Specification of primordial germ cells	6	1.78e-01	2.73e-01	0.49700	4.07e-01	2.85e-01	8.46e-02	2.26e-01
Early Phase of HIV Life Cycle	14	1.88e-02	4.75e-02	0.49700	-3.02e-01	-3.94e-01	5.05e-02	1.07e-02
Interleukin-9 signaling	8	9.25e-02	1.66e-01	0.49600	4.31e-01	2.46e-01	3.48e-02	2.29e-01
Formation of the active cofactor, UDP-glucuronate	5	7.82e-02	1.46e-01	0.49600	-4.53e-01	2.01e-01	7.93e-02	4.36e-01
Regulation of RUNX3 expression and activity	45	5.93e-09	5.91e-08	0.49500	-4.95e-01	2.01e-02	9.15e-09	8.15e-01
InlA-mediated entry of Listeria monocytogenes into host cells	9	7.74e-02	1.45e-01	0.49300	-4.05e-01	-2.81e-01	3.52e-02	1.44e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	8.89e-03	2.57e-02	0.49300	-3.10e-01	-3.83e-01	2.71e-02	6.24e-03
Synthesis of Ketone Bodies	6	1.29e-01	2.15e-01	0.49200	-4.76e-01	-1.25e-01	4.35e-02	5.95e-01
Interconversion of nucleotide di- and triphosphates	27	1.24e-04	6.19e-04	0.49200	-4.71e-01	-1.40e-01	2.24e-05	2.07e-01
Vitamin C (ascorbate) metabolism	8	1.11e-01	1.93e-01	0.49100	3.22e-01	3.70e-01	1.14e-01	6.96e-02
Inactivation of CDC42 and RAC1	7	2.40e-02	5.83e-02	0.49100	-3.25e-01	3.68e-01	1.36e-01	9.21e-02
Phase 4 - resting membrane potential	9	8.10e-02	1.50e-01	0.49000	2.85e-01	3.99e-01	1.39e-01	3.83e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	1.04e-10	1.22e-09	0.49000	-4.84e-01	7.79e-02	1.57e-09	3.31e-01
Cytosolic tRNA aminoacylation	24	2.49e-04	1.17e-03	0.49000	-4.78e-01	-1.08e-01	5.07e-05	3.62e-01
Formation of TC-NER Pre-Incision Complex	51	6.65e-07	4.88e-06	0.49000	-4.00e-01	-2.83e-01	7.75e-07	4.77e-04
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	4.85e-02	1.02e-01	0.48800	-3.89e-01	-2.95e-01	2.54e-02	9.05e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	4.02e-06	2.69e-05	0.48800	-4.80e-01	8.66e-02	1.08e-05	4.27e-01
Scavenging by Class F Receptors	5	1.43e-01	2.32e-01	0.48800	1.88e-02	4.87e-01	9.42e-01	5.91e-02
Formation of the Early Elongation Complex	33	6.39e-05	3.39e-04	0.48800	-4.33e-01	-2.25e-01	1.68e-05	2.55e-02
Formation of the HIV-1 Early Elongation Complex	33	6.39e-05	3.39e-04	0.48800	-4.33e-01	-2.25e-01	1.68e-05	2.55e-02
Heme degradation	10	5.25e-03	1.66e-02	0.48800	-3.18e-01	3.69e-01	8.13e-02	4.31e-02
DNA Replication Pre-Initiation	103	4.80e-17	1.14e-15	0.48700	-4.84e-01	-6.08e-02	2.13e-17	2.87e-01
APC-Cdc20 mediated degradation of Nek2A	26	3.42e-04	1.59e-03	0.48700	-4.51e-01	-1.85e-01	6.95e-05	1.02e-01
Platelet sensitization by LDL	16	8.78e-03	2.55e-02	0.48700	2.14e-01	4.38e-01	1.39e-01	2.43e-03
p53-Dependent G1 DNA Damage Response	52	5.22e-10	5.76e-09	0.48700	-4.86e-01	2.83e-02	1.32e-09	7.24e-01
p53-Dependent G1/S DNA damage checkpoint	52	5.22e-10	5.76e-09	0.48700	-4.86e-01	2.83e-02	1.32e-09	7.24e-01
Signaling by ALK	24	1.58e-03	5.93e-03	0.48700	3.59e-01	3.28e-01	2.30e-03	5.43e-03
Degradation of AXIN	42	4.10e-08	3.70e-07	0.48600	-4.86e-01	1.85e-02	5.04e-08	8.36e-01
Formation of tubulin folding intermediates by CCT/TriC	21	5.09e-05	2.78e-04	0.48600	-4.62e-01	1.51e-01	2.48e-04	2.30e-01
Ketone body metabolism	8	6.03e-02	1.19e-01	0.48500	-4.78e-01	-8.17e-02	1.93e-02	6.89e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	4.97e-02	1.04e-01	0.48500	-4.44e-01	-1.93e-01	1.50e-02	2.89e-01
Interleukin-18 signaling	6	1.62e-01	2.55e-01	0.48400	4.48e-01	1.84e-01	5.75e-02	4.34e-01
TYSND1 cleaves peroxisomal proteins	7	1.44e-01	2.33e-01	0.48400	-4.08e-01	-2.60e-01	6.18e-02	2.33e-01
MECP2 regulates transcription of neuronal ligands	5	1.06e-01	1.86e-01	0.48300	4.70e-01	-1.12e-01	6.85e-02	6.65e-01
Bicarbonate transporters	9	2.57e-02	6.17e-02	0.48300	4.82e-01	-3.02e-02	1.22e-02	8.75e-01
Androgen biosynthesis	5	1.26e-01	2.12e-01	0.48300	-4.81e-01	4.49e-02	6.24e-02	8.62e-01
Nucleotide biosynthesis	12	4.19e-02	9.10e-02	0.48300	-3.49e-01	-3.33e-01	3.61e-02	4.56e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	1.21e-03	4.71e-03	0.48200	2.88e-01	3.87e-01	1.28e-02	8.08e-04
Chromatin modifications during the maternal to zygotic transition (MZT)	23	8.77e-06	5.50e-05	0.48100	-3.84e-01	2.89e-01	1.42e-03	1.65e-02
tRNA processing	128	2.15e-15	4.58e-14	0.48000	-3.77e-01	-2.98e-01	1.74e-13	5.82e-09
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	2.59e-03	9.11e-03	0.47800	-2.64e-01	3.99e-01	1.13e-01	1.68e-02
Transport of connexons to the plasma membrane	12	2.59e-03	9.11e-03	0.47800	-2.64e-01	3.99e-01	1.13e-01	1.68e-02
Biotin transport and metabolism	11	4.17e-02	9.06e-02	0.47800	-1.99e-01	-4.35e-01	2.53e-01	1.26e-02
Interleukin-20 family signaling	17	1.15e-02	3.24e-02	0.47700	3.79e-01	2.90e-01	6.77e-03	3.87e-02
N-Glycan antennae elongation	12	1.43e-02	3.82e-02	0.47700	5.27e-02	4.74e-01	7.52e-01	4.46e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	2.67e-09	2.77e-08	0.47700	-3.70e-01	-3.01e-01	2.44e-08	5.69e-06
Linoleic acid (LA) metabolism	7	1.44e-01	2.33e-01	0.47700	2.29e-01	4.18e-01	2.94e-01	5.55e-02
Degradation of GLI1 by the proteasome	46	3.98e-09	4.05e-08	0.47700	-4.70e-01	7.99e-02	3.46e-08	3.49e-01
Signaling by LTK in cancer	7	1.44e-01	2.33e-01	0.47600	2.28e-01	4.18e-01	2.96e-01	5.54e-02
NIK–>noncanonical NF-kB signaling	46	2.87e-08	2.64e-07	0.47600	-4.76e-01	-2.08e-03	2.33e-08	9.81e-01
DNA Damage Recognition in GG-NER	38	4.83e-05	2.67e-04	0.47500	-3.83e-01	-2.82e-01	4.40e-05	2.64e-03
tRNA Aminoacylation	42	5.42e-06	3.52e-05	0.47500	-4.36e-01	-1.88e-01	9.95e-07	3.51e-02
Sulfur amino acid metabolism	22	3.67e-03	1.22e-02	0.47400	-3.32e-01	-3.39e-01	7.05e-03	5.92e-03
Condensation of Prophase Chromosomes	27	4.38e-06	2.89e-05	0.47400	-4.43e-01	1.69e-01	6.77e-05	1.28e-01
Regulation of PTEN localization	9	1.81e-02	4.60e-02	0.47400	-4.52e-01	1.43e-01	1.89e-02	4.57e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	3.31e-05	1.91e-04	0.47400	-4.68e-01	7.41e-02	5.14e-05	5.21e-01
Switching of origins to a post-replicative state	79	6.75e-13	1.05e-11	0.47300	-4.72e-01	-3.77e-02	4.12e-13	5.62e-01
PI3K/AKT activation	8	7.56e-02	1.42e-01	0.47300	1.03e-01	4.61e-01	6.15e-01	2.38e-02
VEGF binds to VEGFR leading to receptor dimerization	5	9.37e-02	1.67e-01	0.47300	-4.18e-01	2.21e-01	1.06e-01	3.92e-01
VEGF ligand-receptor interactions	5	9.37e-02	1.67e-01	0.47300	-4.18e-01	2.21e-01	1.06e-01	3.92e-01
ABC transporter disorders	59	6.80e-12	9.26e-11	0.47200	-4.54e-01	1.29e-01	1.57e-09	8.69e-02
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	2.65e-01	3.70e-01	0.47200	-2.46e-01	-4.03e-01	3.40e-01	1.19e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	6.81e-14	1.19e-12	0.47200	-4.51e-01	1.38e-01	8.80e-11	4.76e-02
PRC2 methylates histones and DNA	27	2.76e-05	1.61e-04	0.47200	-4.71e-01	3.27e-02	2.30e-05	7.69e-01
APC/C-mediated degradation of cell cycle proteins	75	2.64e-13	4.38e-12	0.47100	-4.70e-01	2.96e-02	1.82e-12	6.58e-01
Regulation of mitotic cell cycle	75	2.64e-13	4.38e-12	0.47100	-4.70e-01	2.96e-02	1.82e-12	6.58e-01
Telomere Maintenance	78	4.91e-11	6.13e-10	0.47100	-4.51e-01	-1.35e-01	5.65e-12	3.86e-02
FLT3 signaling by CBL mutants	7	1.41e-01	2.30e-01	0.47100	-4.28e-01	-1.96e-01	4.99e-02	3.70e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.75e-03	9.55e-03	0.47000	-4.29e-01	-1.92e-01	6.62e-04	1.28e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.75e-03	9.55e-03	0.47000	-4.29e-01	-1.92e-01	6.62e-04	1.28e-01
FCGR activation	75	1.32e-15	2.84e-14	0.46900	-4.29e-01	1.92e-01	1.36e-10	4.12e-03
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	6.67e-05	3.53e-04	0.46800	-4.56e-01	1.05e-01	1.53e-04	3.84e-01
Signaling by FGFR4 in disease	11	6.30e-02	1.23e-01	0.46600	3.75e-01	2.76e-01	3.12e-02	1.13e-01
Adenylate cyclase inhibitory pathway	11	6.05e-02	1.19e-01	0.46600	3.88e-01	2.59e-01	2.60e-02	1.37e-01
VLDLR internalisation and degradation	16	3.38e-03	1.14e-02	0.46600	-4.66e-01	-1.48e-02	1.26e-03	9.18e-01
Formation of Incision Complex in GG-NER	43	2.03e-05	1.22e-04	0.46600	-3.77e-01	-2.73e-01	1.86e-05	1.96e-03
Degradation of cysteine and homocysteine	12	5.26e-02	1.08e-01	0.46500	-3.24e-01	-3.34e-01	5.23e-02	4.49e-02
Maturation of protein 3a 9683673	9	5.88e-02	1.17e-01	0.46500	9.69e-02	4.55e-01	6.15e-01	1.81e-02
Maturation of protein 3a 9694719	9	5.88e-02	1.17e-01	0.46500	9.69e-02	4.55e-01	6.15e-01	1.81e-02
Telomere C-strand synthesis initiation	13	3.20e-02	7.42e-02	0.46400	-2.15e-01	-4.11e-01	1.80e-01	1.03e-02
Meiotic recombination	36	4.27e-06	2.83e-05	0.46400	-4.63e-01	-3.25e-02	1.55e-06	7.36e-01
Josephin domain DUBs	10	2.68e-02	6.40e-02	0.46400	-4.64e-01	4.50e-03	1.11e-02	9.80e-01
Regulation of innate immune responses to cytosolic DNA	14	3.13e-02	7.28e-02	0.46400	-2.83e-01	-3.67e-01	6.72e-02	1.73e-02
mRNA Splicing	211	3.76e-23	1.39e-21	0.46300	-3.65e-01	-2.85e-01	5.97e-20	9.42e-13
Myogenesis	20	7.23e-03	2.16e-02	0.46200	3.71e-01	2.75e-01	4.09e-03	3.32e-02
DNA Replication	128	7.06e-19	2.00e-17	0.46100	-4.58e-01	-5.67e-02	3.65e-19	2.68e-01
Endosomal/Vacuolar pathway	11	7.04e-02	1.34e-01	0.46100	-3.38e-01	-3.13e-01	5.19e-02	7.23e-02
Metabolism of cofactors	25	9.82e-04	4.00e-03	0.46000	-4.29e-01	-1.66e-01	2.05e-04	1.51e-01
Regulation of Complement cascade	95	8.63e-19	2.40e-17	0.46000	-4.20e-01	1.88e-01	1.53e-12	1.56e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	7.39e-02	1.40e-01	0.45900	-3.81e-02	4.58e-01	8.61e-01	3.59e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.71e-03	6.33e-03	0.45900	-2.42e-01	3.91e-01	1.18e-01	1.13e-02
Synthesis of DNA	108	4.72e-15	9.54e-14	0.45900	-4.49e-01	-9.64e-02	7.03e-16	8.35e-02
Telomere C-strand (Lagging Strand) Synthesis	34	2.65e-04	1.25e-03	0.45900	-2.77e-01	-3.65e-01	5.10e-03	2.29e-04
Prostanoid ligand receptors	8	2.52e-02	6.09e-02	0.45700	-2.92e-01	3.51e-01	1.52e-01	8.54e-02
Interleukin-2 signaling	11	5.90e-02	1.17e-01	0.45600	4.07e-01	2.06e-01	1.95e-02	2.38e-01
Somitogenesis	41	4.27e-08	3.83e-07	0.45600	-4.33e-01	1.42e-01	1.60e-06	1.15e-01
NOTCH2 intracellular domain regulates transcription	11	7.50e-02	1.41e-01	0.45600	3.30e-01	3.14e-01	5.79e-02	7.12e-02
Presynaptic depolarization and calcium channel opening	8	2.73e-02	6.50e-02	0.45600	3.82e-01	-2.49e-01	6.16e-02	2.23e-01
Dectin-1 mediated noncanonical NF-kB signaling	47	7.61e-08	6.50e-07	0.45400	-4.54e-01	7.22e-03	7.02e-08	9.32e-01
mRNA Splicing - Major Pathway	203	1.82e-21	6.25e-20	0.45400	-3.56e-01	-2.82e-01	1.94e-18	4.52e-12
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	2.32e-02	5.69e-02	0.45400	-4.22e-01	-1.66e-01	6.23e-03	2.82e-01
p75NTR recruits signalling complexes	12	4.00e-02	8.77e-02	0.45300	-4.22e-01	-1.66e-01	1.14e-02	3.20e-01
STAT3 nuclear events downstream of ALK signaling	11	6.77e-02	1.30e-01	0.45300	3.87e-01	2.36e-01	2.64e-02	1.75e-01
Signaling by LTK	10	9.03e-02	1.63e-01	0.45300	3.75e-01	2.54e-01	4.00e-02	1.64e-01
Apoptotic factor-mediated response	19	8.01e-03	2.36e-02	0.45300	-4.04e-01	-2.04e-01	2.28e-03	1.24e-01
CREB3 factors activate genes	6	2.32e-01	3.35e-01	0.45300	-2.40e-01	-3.84e-01	3.09e-01	1.04e-01
Translocation of ZAP-70 to Immunological synapse	24	1.29e-04	6.36e-04	0.45300	6.34e-02	-4.48e-01	5.91e-01	1.44e-04
Common Pathway of Fibrin Clot Formation	13	1.41e-02	3.76e-02	0.45100	2.48e-02	4.50e-01	8.77e-01	4.95e-03
RHO GTPases activate KTN1	11	3.42e-02	7.81e-02	0.45100	6.84e-02	4.45e-01	6.95e-01	1.05e-02
Polo-like kinase mediated events	16	7.69e-04	3.22e-03	0.45000	-3.00e-01	3.36e-01	3.78e-02	2.00e-02
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	2.75e-03	9.55e-03	0.45000	-4.46e-01	6.14e-02	2.02e-03	6.71e-01
Pausing and recovery of Tat-mediated HIV elongation	30	5.51e-04	2.38e-03	0.45000	-4.01e-01	-2.03e-01	1.43e-04	5.42e-02
Tat-mediated HIV elongation arrest and recovery	30	5.51e-04	2.38e-03	0.45000	-4.01e-01	-2.03e-01	1.43e-04	5.42e-02
SARS-CoV-1-host interactions	94	2.65e-10	3.07e-09	0.44900	-3.69e-01	-2.56e-01	6.20e-10	1.85e-05
Role of LAT2/NTAL/LAB on calcium mobilization	76	6.61e-15	1.28e-13	0.44900	-3.90e-01	2.21e-01	3.94e-09	8.54e-04
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	1.92e-01	2.89e-01	0.44800	3.72e-01	2.49e-01	8.81e-02	2.53e-01
Formyl peptide receptors bind formyl peptides and many other ligands	7	7.24e-02	1.37e-01	0.44700	-4.39e-01	8.50e-02	4.43e-02	6.97e-01
Erythrocytes take up carbon dioxide and release oxygen	11	6.34e-02	1.23e-01	0.44700	1.91e-01	4.04e-01	2.72e-01	2.04e-02
O2/CO2 exchange in erythrocytes	11	6.34e-02	1.23e-01	0.44700	1.91e-01	4.04e-01	2.72e-01	2.04e-02
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	1.56e-01	2.47e-01	0.44700	2.60e-01	3.63e-01	2.03e-01	7.52e-02
Adherens junctions interactions	36	1.62e-04	7.88e-04	0.44600	3.91e-01	2.15e-01	4.83e-05	2.58e-02
Role of ABL in ROBO-SLIT signaling	6	2.27e-01	3.31e-01	0.44600	1.99e-01	3.99e-01	3.98e-01	9.05e-02
Condensation of Prometaphase Chromosomes	11	8.12e-03	2.39e-02	0.44500	-3.40e-01	2.88e-01	5.11e-02	9.82e-02
Metabolism of folate and pterines	16	6.19e-03	1.90e-02	0.44500	-4.44e-01	-2.70e-02	2.12e-03	8.52e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	5.80e-09	5.81e-08	0.44300	-3.52e-01	-2.69e-01	2.43e-08	1.96e-05
SOS-mediated signalling	7	1.19e-01	2.01e-01	0.44300	5.10e-02	4.40e-01	8.15e-01	4.37e-02
Platelet Adhesion to exposed collagen	14	2.77e-03	9.55e-03	0.44200	-2.32e-01	3.76e-01	1.33e-01	1.48e-02
Activation of SMO	13	4.12e-02	9.00e-02	0.44000	4.00e-01	1.84e-01	1.24e-02	2.52e-01
Chromosome Maintenance	102	3.20e-12	4.56e-11	0.44000	-4.17e-01	-1.42e-01	3.48e-13	1.30e-02
Mismatch Repair	15	1.53e-02	4.02e-02	0.44000	-4.29e-01	-9.66e-02	4.01e-03	5.17e-01
Polymerase switching on the C-strand of the telomere	26	3.07e-03	1.05e-02	0.43800	-2.58e-01	-3.54e-01	2.28e-02	1.76e-03
Regulation of gene expression in beta cells	7	2.16e-01	3.19e-01	0.43800	3.31e-01	2.87e-01	1.29e-01	1.88e-01
Dual incision in TC-NER	63	9.02e-07	6.54e-06	0.43700	-3.51e-01	-2.61e-01	1.41e-06	3.44e-04
Reactions specific to the complex N-glycan synthesis pathway	7	1.06e-01	1.86e-01	0.43700	-4.37e-01	7.98e-04	4.52e-02	9.97e-01
RHO GTPases activate PKNs	46	8.68e-09	8.50e-08	0.43700	-3.88e-01	2.02e-01	5.38e-06	1.80e-02
FCERI mediated NF-kB activation	128	3.49e-22	1.22e-20	0.43700	-4.08e-01	1.55e-01	1.49e-15	2.44e-03
Signaling by Leptin	10	8.82e-02	1.59e-01	0.43500	1.73e-01	4.00e-01	3.44e-01	2.86e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	4.19e-02	9.10e-02	0.43500	-4.01e-01	-1.68e-01	1.22e-02	2.95e-01
Post-chaperonin tubulin folding pathway	18	8.17e-04	3.39e-03	0.43500	-3.94e-01	1.84e-01	3.78e-03	1.77e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	7.56e-03	2.24e-02	0.43500	1.67e-01	4.02e-01	1.97e-01	1.86e-03
Phosphorylation of the APC/C	20	6.23e-03	1.90e-02	0.43500	-4.12e-01	-1.39e-01	1.44e-03	2.80e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	7.04e-05	3.66e-04	0.43300	-3.79e-01	-2.11e-01	2.18e-05	1.82e-02
HIV Transcription Elongation	42	7.04e-05	3.66e-04	0.43300	-3.79e-01	-2.11e-01	2.18e-05	1.82e-02
Tat-mediated elongation of the HIV-1 transcript	42	7.04e-05	3.66e-04	0.43300	-3.79e-01	-2.11e-01	2.18e-05	1.82e-02
Interleukin-6 family signaling	18	1.51e-02	3.99e-02	0.43300	3.88e-01	1.92e-01	4.39e-03	1.58e-01
Branched-chain amino acid catabolism	21	1.16e-02	3.26e-02	0.43200	-3.22e-01	-2.88e-01	1.06e-02	2.23e-02
Complement cascade	99	6.76e-17	1.58e-15	0.43200	-4.06e-01	1.48e-01	2.99e-12	1.09e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	62	1.56e-06	1.10e-05	0.43200	-3.49e-01	-2.55e-01	2.02e-06	5.28e-04
Removal of the Flap Intermediate from the C-strand	17	1.98e-02	4.96e-02	0.43100	-3.86e-01	-1.91e-01	5.85e-03	1.73e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	2.99e-02	7.00e-02	0.43100	-4.21e-01	8.93e-02	2.11e-02	6.25e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	2.04e-03	7.40e-03	0.43000	-3.69e-01	-2.22e-01	7.33e-04	4.23e-02
Platelet degranulation	104	2.08e-18	5.70e-17	0.43000	-3.79e-01	2.03e-01	2.29e-11	3.55e-04
RNA Polymerase III Transcription Initiation	36	3.98e-04	1.81e-03	0.43000	-3.59e-01	-2.36e-01	1.91e-04	1.42e-02
Induction of Cell-Cell Fusion	8	8.78e-02	1.59e-01	0.43000	1.14e-02	4.30e-01	9.56e-01	3.53e-02
Metabolism of non-coding RNA	53	1.38e-05	8.44e-05	0.43000	-2.72e-01	-3.33e-01	6.19e-04	2.74e-05
snRNP Assembly	53	1.38e-05	8.44e-05	0.43000	-2.72e-01	-3.33e-01	6.19e-04	2.74e-05
mRNA Capping	29	1.33e-03	5.11e-03	0.43000	-3.83e-01	-1.94e-01	3.51e-04	7.10e-02
Signaling by FGFR2 IIIa TM	18	1.58e-02	4.12e-02	0.42900	-3.87e-01	-1.86e-01	4.50e-03	1.72e-01
Regulation of RUNX2 expression and activity	54	6.48e-08	5.66e-07	0.42900	-4.29e-01	-1.70e-03	4.97e-08	9.83e-01
2-LTR circle formation	7	2.30e-01	3.33e-01	0.42900	-2.72e-01	-3.31e-01	2.13e-01	1.29e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	7.68e-03	2.27e-02	0.42800	6.33e-03	4.28e-01	9.65e-01	3.00e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.92e-02	4.84e-02	0.42800	-4.06e-01	-1.37e-01	4.93e-03	3.44e-01
Leading Strand Synthesis	14	5.36e-02	1.09e-01	0.42800	-3.25e-01	-2.78e-01	3.50e-02	7.13e-02
Polymerase switching	14	5.36e-02	1.09e-01	0.42800	-3.25e-01	-2.78e-01	3.50e-02	7.13e-02
Response to elevated platelet cytosolic Ca2+	108	5.21e-19	1.54e-17	0.42800	-3.74e-01	2.08e-01	1.87e-11	1.81e-04
Phenylalanine and tyrosine metabolism	9	1.28e-01	2.13e-01	0.42800	-3.84e-01	-1.88e-01	4.59e-02	3.28e-01
CDH11 homotypic and heterotypic interactions	5	2.50e-01	3.54e-01	0.42800	4.23e-01	6.43e-02	1.01e-01	8.03e-01
Telomere Extension By Telomerase	23	4.23e-04	1.91e-03	0.42700	-4.21e-01	7.16e-02	4.72e-04	5.52e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	2.58e-02	6.20e-02	0.42700	3.85e-01	1.84e-01	7.61e-03	2.03e-01
ChREBP activates metabolic gene expression	7	1.22e-01	2.06e-01	0.42700	8.05e-03	4.27e-01	9.71e-01	5.06e-02
tRNA processing in the nucleus	59	3.94e-06	2.64e-05	0.42600	-2.49e-01	-3.47e-01	9.60e-04	4.12e-06
H139Hfs13* PPM1K causes a mild variant of MSUD	5	3.37e-01	4.38e-01	0.42600	-2.17e-01	-3.66e-01	4.00e-01	1.56e-01
Maple Syrup Urine Disease	5	3.37e-01	4.38e-01	0.42600	-2.17e-01	-3.66e-01	4.00e-01	1.56e-01
Regulation of RAS by GAPs	55	3.80e-09	3.88e-08	0.42500	-4.10e-01	1.13e-01	1.42e-07	1.47e-01
Asymmetric localization of PCP proteins	49	1.37e-07	1.13e-06	0.42500	-4.22e-01	4.57e-02	3.12e-07	5.80e-01
MECP2 regulates transcription factors	5	2.17e-01	3.20e-01	0.42400	4.24e-01	-9.94e-03	1.01e-01	9.69e-01
The activation of arylsulfatases	10	1.29e-01	2.13e-01	0.42400	-3.27e-01	-2.70e-01	7.37e-02	1.40e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	4.69e-02	9.91e-02	0.42400	-4.23e-01	1.26e-02	2.04e-02	9.45e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.58e-02	4.13e-02	0.42300	-3.40e-01	-2.53e-01	8.53e-03	5.03e-02
Regulation of HMOX1 expression and activity	5	3.53e-01	4.55e-01	0.42200	2.38e-01	3.48e-01	3.56e-01	1.78e-01
Cellular response to hypoxia	59	1.47e-09	1.55e-08	0.42100	-4.07e-01	1.09e-01	6.40e-08	1.46e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	3.52e-01	4.53e-01	0.42000	2.28e-01	3.53e-01	3.78e-01	1.71e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	4.32e-02	9.29e-02	0.42000	4.20e-01	2.23e-02	1.59e-02	8.98e-01
B-WICH complex positively regulates rRNA expression	45	2.30e-06	1.58e-05	0.42000	-4.20e-01	-1.52e-02	1.08e-06	8.60e-01
Nucleotide Excision Repair	108	3.78e-10	4.30e-09	0.42000	-3.24e-01	-2.67e-01	5.73e-09	1.67e-06
Transport of nucleotide sugars	9	1.65e-01	2.58e-01	0.41900	-3.16e-01	-2.76e-01	1.01e-01	1.52e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	2.27e-01	3.31e-01	0.41900	-4.51e-03	4.19e-01	9.86e-01	1.05e-01
Budding and maturation of HIV virion	26	5.27e-04	2.29e-03	0.41800	-4.18e-01	-5.45e-03	2.22e-04	9.62e-01
Sema4D mediated inhibition of cell attachment and migration	7	7.82e-02	1.46e-01	0.41800	-3.79e-01	1.75e-01	8.23e-02	4.21e-01
FGFR2 alternative splicing	25	4.79e-03	1.53e-02	0.41700	-3.69e-01	-1.93e-01	1.38e-03	9.49e-02
Digestion	5	2.29e-01	3.32e-01	0.41700	-1.01e-02	4.16e-01	9.69e-01	1.07e-01
BBSome-mediated cargo-targeting to cilium	22	1.11e-02	3.13e-02	0.41600	-2.26e-01	-3.50e-01	6.64e-02	4.52e-03
Gap junction assembly	16	3.80e-03	1.26e-02	0.41600	-1.41e-01	3.91e-01	3.29e-01	6.78e-03
Transcriptional Regulation by NPAS4	27	5.05e-03	1.61e-02	0.41500	2.76e-01	3.10e-01	1.29e-02	5.32e-03
RNA Polymerase II Transcription Termination	66	2.27e-06	1.56e-05	0.41500	-3.23e-01	-2.61e-01	5.72e-06	2.47e-04
HIV elongation arrest and recovery	32	1.09e-03	4.32e-03	0.41400	-3.71e-01	-1.85e-01	2.81e-04	7.02e-02
Pausing and recovery of HIV elongation	32	1.09e-03	4.32e-03	0.41400	-3.71e-01	-1.85e-01	2.81e-04	7.02e-02
NFE2L2 regulating ER-stress associated genes	5	3.76e-01	4.78e-01	0.41400	3.13e-01	2.72e-01	2.26e-01	2.93e-01
Amyloid fiber formation	51	4.34e-07	3.30e-06	0.41300	-4.13e-01	3.85e-03	3.27e-07	9.62e-01
MASTL Facilitates Mitotic Progression	10	3.23e-02	7.47e-02	0.41300	-3.89e-01	1.38e-01	3.31e-02	4.51e-01
Reduction of cytosolic Ca++ levels	9	8.72e-02	1.58e-01	0.41300	3.17e-02	4.12e-01	8.69e-01	3.25e-02
Regulation of PTEN stability and activity	55	2.65e-08	2.46e-07	0.41200	-4.05e-01	7.70e-02	2.07e-07	3.23e-01
Processing of Capped Intron-Containing Pre-mRNA	279	4.70e-24	1.81e-22	0.41200	-3.22e-01	-2.57e-01	2.16e-20	1.40e-13
Downregulation of ERBB4 signaling	8	1.71e-01	2.65e-01	0.41200	-3.83e-01	-1.53e-01	6.10e-02	4.55e-01
Insulin receptor recycling	24	1.25e-04	6.20e-04	0.41200	-3.03e-01	2.78e-01	1.01e-02	1.83e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	6.67e-04	2.82e-03	0.41000	-3.20e-01	-2.56e-01	6.41e-04	6.27e-03
Interleukin-2 family signaling	38	5.71e-04	2.46e-03	0.40900	3.42e-01	2.24e-01	2.67e-04	1.68e-02
Formation of the nephric duct	8	1.09e-01	1.90e-01	0.40900	5.00e-03	4.09e-01	9.80e-01	4.54e-02
Formation of HIV elongation complex in the absence of HIV Tat	44	1.34e-04	6.60e-04	0.40800	-3.58e-01	-1.97e-01	4.05e-05	2.36e-02
RNA Polymerase III Abortive And Retractive Initiation	40	3.68e-04	1.69e-03	0.40800	-3.46e-01	-2.16e-01	1.51e-04	1.79e-02
RNA Polymerase III Transcription	40	3.68e-04	1.69e-03	0.40800	-3.46e-01	-2.16e-01	1.51e-04	1.79e-02
Physiological factors	9	1.42e-01	2.31e-01	0.40800	3.79e-01	1.51e-01	4.90e-02	4.33e-01
Nephrin family interactions	19	2.60e-02	6.23e-02	0.40700	2.40e-01	3.29e-01	7.06e-02	1.30e-02
Biosynthesis of EPA-derived SPMs	6	3.08e-01	4.16e-01	0.40700	2.19e-01	3.43e-01	3.52e-01	1.46e-01
Diseases associated with N-glycosylation of proteins	20	1.22e-02	3.38e-02	0.40700	-3.83e-01	-1.37e-01	3.01e-03	2.89e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	82	1.49e-13	2.51e-12	0.40700	-3.32e-01	2.34e-01	1.94e-07	2.44e-04
Intrinsic Pathway of Fibrin Clot Formation	15	5.07e-03	1.61e-02	0.40600	-3.54e-01	1.99e-01	1.75e-02	1.82e-01
IkBA variant leads to EDA-ID	7	2.30e-01	3.33e-01	0.40500	3.71e-01	1.62e-01	8.88e-02	4.58e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	3.17e-03	1.08e-02	0.40500	-3.76e-01	-1.52e-01	7.25e-04	1.73e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	3.17e-03	1.08e-02	0.40500	-3.76e-01	-1.52e-01	7.25e-04	1.73e-01
Negative epigenetic regulation of rRNA expression	63	3.51e-07	2.70e-06	0.40500	-3.95e-01	-8.90e-02	5.85e-08	2.22e-01
Processing of Capped Intronless Pre-mRNA	29	4.44e-03	1.44e-02	0.40500	-3.09e-01	-2.61e-01	3.92e-03	1.50e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	1.35e-02	3.65e-02	0.40500	-3.26e-01	2.40e-01	5.06e-02	1.50e-01
Processive synthesis on the C-strand of the telomere	19	2.10e-02	5.20e-02	0.40500	-3.62e-01	-1.80e-01	6.26e-03	1.74e-01
Interleukin-4 and Interleukin-13 signaling	89	2.16e-08	2.03e-07	0.40400	1.95e-01	3.54e-01	1.45e-03	7.70e-09
Regulation of PTEN mRNA translation	12	1.05e-01	1.83e-01	0.40400	3.22e-01	2.44e-01	5.34e-02	1.44e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	9	1.36e-01	2.24e-01	0.40300	3.84e-01	1.21e-01	4.58e-02	5.30e-01
Signaling by PDGFRA extracellular domain mutants	12	8.64e-02	1.57e-01	0.40300	1.71e-01	3.65e-01	3.04e-01	2.88e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.64e-02	1.57e-01	0.40300	1.71e-01	3.65e-01	3.04e-01	2.88e-02
O-linked glycosylation of mucins	46	5.97e-05	3.22e-04	0.40200	1.45e-01	3.75e-01	8.84e-02	1.08e-05
NoRC negatively regulates rRNA expression	60	5.68e-07	4.20e-06	0.40200	-3.96e-01	-7.03e-02	1.15e-07	3.46e-01
Regulation of CDH11 gene transcription	5	3.28e-01	4.31e-01	0.40200	3.86e-01	1.12e-01	1.35e-01	6.64e-01
Regulation of IFNG signaling	14	4.68e-02	9.91e-02	0.40200	1.24e-01	3.82e-01	4.21e-01	1.33e-02
EGFR downregulation	26	6.01e-04	2.58e-03	0.40100	-3.63e-02	4.00e-01	7.49e-01	4.16e-04
Regulation of beta-cell development	21	2.16e-02	5.35e-02	0.40100	2.71e-01	2.95e-01	3.14e-02	1.91e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	1.16e-01	1.98e-01	0.40100	-4.01e-01	2.37e-03	4.97e-02	9.91e-01
Defective LFNG causes SCDO3	5	3.57e-01	4.58e-01	0.40100	1.57e-01	3.68e-01	5.42e-01	1.54e-01
N-glycan trimming and elongation in the cis-Golgi	5	3.57e-01	4.58e-01	0.40100	-3.69e-01	-1.56e-01	1.53e-01	5.45e-01
Other semaphorin interactions	16	4.74e-02	1.00e-01	0.40100	2.12e-01	3.40e-01	1.42e-01	1.86e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	4.54e-02	9.69e-02	0.40000	-3.02e-01	-2.62e-01	3.13e-02	6.10e-02
Branched-chain ketoacid dehydrogenase kinase deficiency	5	4.04e-01	5.05e-01	0.39900	-2.99e-01	-2.65e-01	2.47e-01	3.05e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	4.20e-05	2.37e-04	0.39900	-3.51e-01	-1.90e-01	1.22e-05	1.78e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	24	3.05e-04	1.43e-03	0.39800	-3.50e-01	1.90e-01	2.97e-03	1.08e-01
DNA strand elongation	32	2.87e-03	9.86e-03	0.39700	-3.22e-01	-2.33e-01	1.63e-03	2.25e-02
ATF4 activates genes in response to endoplasmic reticulum stress	25	9.84e-03	2.82e-02	0.39700	-3.30e-01	-2.20e-01	4.28e-03	5.66e-02
Activation of NF-kappaB in B cells	54	8.92e-08	7.58e-07	0.39600	-3.85e-01	9.22e-02	9.66e-07	2.41e-01
TNFR1-mediated ceramide production	6	3.46e-01	4.47e-01	0.39500	-2.78e-01	-2.80e-01	2.38e-01	2.34e-01
Free fatty acids regulate insulin secretion	10	1.34e-01	2.21e-01	0.39500	1.52e-01	3.64e-01	4.06e-01	4.60e-02
RUNX3 regulates CDKN1A transcription	7	1.21e-01	2.05e-01	0.39500	9.94e-02	-3.82e-01	6.49e-01	8.02e-02
RUNX3 regulates NOTCH signaling	14	8.36e-02	1.54e-01	0.39400	2.99e-01	2.58e-01	5.30e-02	9.51e-02
FGFR2 mutant receptor activation	23	1.51e-02	3.99e-02	0.39400	-3.27e-01	-2.21e-01	6.64e-03	6.70e-02
Anchoring fibril formation	7	2.79e-01	3.87e-01	0.39400	2.17e-01	3.28e-01	3.20e-01	1.33e-01
RNA Polymerase I Promoter Clearance	64	2.20e-06	1.52e-05	0.39300	-3.68e-01	-1.36e-01	3.43e-07	5.94e-02
RNA Polymerase I Transcription	64	2.20e-06	1.52e-05	0.39300	-3.68e-01	-1.36e-01	3.43e-07	5.94e-02
GP1b-IX-V activation signalling	10	3.43e-02	7.84e-02	0.39200	-3.15e-01	2.33e-01	8.41e-02	2.02e-01
Interleukin-37 signaling	19	3.48e-02	7.92e-02	0.39200	2.41e-01	3.09e-01	6.87e-02	1.96e-02
PERK regulates gene expression	30	2.67e-03	9.33e-03	0.39200	-3.61e-01	-1.51e-01	6.14e-04	1.51e-01
PKA activation	15	6.08e-02	1.20e-01	0.39200	1.89e-01	3.43e-01	2.05e-01	2.14e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	4.81e-04	2.15e-03	0.39200	2.81e-01	2.73e-01	1.28e-03	1.72e-03
Kidney development	16	1.35e-02	3.65e-02	0.39100	-3.07e-02	3.90e-01	8.32e-01	6.90e-03
Tight junction interactions	17	2.95e-02	6.94e-02	0.39100	-1.21e-01	-3.72e-01	3.86e-01	7.95e-03
SHC-related events triggered by IGF1R	7	2.92e-01	4.00e-01	0.39100	2.39e-01	3.10e-01	2.74e-01	1.56e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	1.24e-08	1.20e-07	0.39100	-3.89e-01	-3.63e-02	4.50e-09	5.85e-01
Extension of Telomeres	51	7.84e-05	4.06e-04	0.39000	-3.42e-01	-1.88e-01	2.35e-05	2.02e-02
Glutathione conjugation	26	8.76e-04	3.58e-03	0.39000	-3.88e-01	4.00e-02	6.23e-04	7.24e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	2.06e-02	5.14e-02	0.38900	3.40e-01	-1.89e-01	4.12e-02	2.56e-01
Nuclear events mediated by NFE2L2	81	2.00e-12	2.88e-11	0.38900	-3.04e-01	2.43e-01	2.18e-06	1.59e-04
Estrogen biosynthesis	5	3.92e-01	4.92e-01	0.38900	1.77e-01	3.46e-01	4.93e-01	1.80e-01
Dectin-2 family	18	4.55e-02	9.70e-02	0.38900	2.61e-01	2.88e-01	5.53e-02	3.42e-02
Smooth Muscle Contraction	34	1.18e-05	7.28e-05	0.38800	-2.78e-01	2.71e-01	5.02e-03	6.19e-03
FCGR3A-mediated phagocytosis	120	8.03e-18	2.03e-16	0.38800	-3.16e-01	2.25e-01	2.20e-09	2.00e-05
Leishmania phagocytosis	120	8.03e-18	2.03e-16	0.38800	-3.16e-01	2.25e-01	2.20e-09	2.00e-05
Parasite infection	120	8.03e-18	2.03e-16	0.38800	-3.16e-01	2.25e-01	2.20e-09	2.00e-05
Uptake and function of diphtheria toxin	6	1.51e-01	2.42e-01	0.38800	-1.66e-01	3.51e-01	4.81e-01	1.37e-01
HDL assembly	6	3.35e-01	4.37e-01	0.38800	3.38e-01	1.90e-01	1.52e-01	4.20e-01
DNA Damage Bypass	47	3.16e-04	1.48e-03	0.38700	-3.00e-01	-2.45e-01	3.70e-04	3.68e-03
SARS-CoV-2 modulates autophagy	11	1.54e-01	2.45e-01	0.38700	-2.68e-01	-2.79e-01	1.23e-01	1.09e-01
Synthesis of PIPs at the ER membrane	5	2.20e-01	3.23e-01	0.38700	3.63e-01	-1.33e-01	1.59e-01	6.08e-01
Repression of WNT target genes	14	8.40e-02	1.54e-01	0.38700	2.08e-01	3.26e-01	1.77e-01	3.48e-02
Defective factor IX causes hemophilia B	6	1.41e-01	2.30e-01	0.38600	-3.11e-01	2.28e-01	1.86e-01	3.33e-01
DNA Damage Reversal	8	2.31e-01	3.34e-01	0.38600	-3.42e-01	-1.79e-01	9.41e-02	3.81e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	8.54e-02	1.56e-01	0.38500	-3.70e-01	-1.09e-01	2.66e-02	5.13e-01
ALK mutants bind TKIs	11	1.43e-01	2.32e-01	0.38500	2.00e-01	3.29e-01	2.51e-01	5.92e-02
Signaling by WNT in cancer	30	5.68e-03	1.77e-02	0.38500	3.15e-01	2.20e-01	2.80e-03	3.67e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	9.07e-02	1.63e-01	0.38500	-3.82e-01	4.66e-02	4.74e-02	8.09e-01
Establishment of Sister Chromatid Cohesion	11	1.31e-01	2.18e-01	0.38500	1.69e-01	3.46e-01	3.32e-01	4.72e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	9.34e-02	1.67e-01	0.38400	2.41e-01	2.99e-01	1.18e-01	5.24e-02
CHL1 interactions	8	1.14e-01	1.96e-01	0.38400	-6.01e-02	3.79e-01	7.68e-01	6.32e-02
Cross-presentation of particulate exogenous antigens (phagosomes)	8	2.08e-01	3.09e-01	0.38400	1.29e-01	3.62e-01	5.29e-01	7.64e-02
Activation of Matrix Metalloproteinases	20	1.39e-02	3.74e-02	0.38400	7.97e-02	3.75e-01	5.37e-01	3.67e-03
Cyclin E associated events during G1/S transition	73	1.41e-09	1.50e-08	0.38300	-3.74e-01	8.47e-02	3.37e-08	2.11e-01
RUNX1 regulates expression of components of tight junctions	5	3.74e-01	4.77e-01	0.38200	1.21e-01	3.62e-01	6.40e-01	1.61e-01
STAT5 Activation	7	2.60e-01	3.65e-01	0.38200	1.33e-01	3.58e-01	5.42e-01	1.01e-01
Prevention of phagosomal-lysosomal fusion	9	1.27e-01	2.12e-01	0.38200	-3.80e-01	-3.44e-02	4.84e-02	8.58e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	3.15e-01	4.20e-01	0.38100	2.56e-01	2.82e-01	2.41e-01	1.96e-01
FCERI mediated MAPK activation	92	3.15e-13	5.18e-12	0.38100	-3.22e-01	2.03e-01	9.08e-08	7.55e-04
Activation of RAS in B cells	5	4.39e-01	5.37e-01	0.38000	2.86e-01	2.51e-01	2.69e-01	3.31e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	3.82e-02	8.48e-02	0.38000	-2.73e-01	-2.64e-01	3.46e-02	4.12e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	2.67e-07	2.07e-06	0.37900	-2.33e-01	2.99e-01	5.28e-03	3.34e-04
Regulation of actin dynamics for phagocytic cup formation	122	2.17e-17	5.35e-16	0.37900	-2.97e-01	2.35e-01	1.43e-08	7.33e-06
Purine catabolism	16	4.60e-02	9.77e-02	0.37800	-3.58e-01	-1.20e-01	1.31e-02	4.06e-01
Disorders of Developmental Biology	12	1.27e-01	2.12e-01	0.37800	3.26e-01	1.90e-01	5.02e-02	2.55e-01
Disorders of Nervous System Development	12	1.27e-01	2.12e-01	0.37800	3.26e-01	1.90e-01	5.02e-02	2.55e-01
Loss of function of MECP2 in Rett syndrome	12	1.27e-01	2.12e-01	0.37800	3.26e-01	1.90e-01	5.02e-02	2.55e-01
Pervasive developmental disorders	12	1.27e-01	2.12e-01	0.37800	3.26e-01	1.90e-01	5.02e-02	2.55e-01
PCP/CE pathway	74	1.40e-09	1.50e-08	0.37700	-3.65e-01	9.61e-02	5.70e-08	1.53e-01
p75NTR negatively regulates cell cycle via SC1	5	2.38e-01	3.41e-01	0.37700	-3.54e-01	1.29e-01	1.70e-01	6.18e-01
FCERI mediated Ca+2 mobilization	91	6.28e-13	9.89e-12	0.37700	-3.09e-01	2.16e-01	3.47e-07	3.78e-04
Attachment and Entry 9694614	13	8.34e-02	1.54e-01	0.37700	1.20e-01	3.57e-01	4.55e-01	2.58e-02
RHO GTPases Activate Rhotekin and Rhophilins	8	2.64e-01	3.69e-01	0.37600	-3.13e-01	-2.08e-01	1.25e-01	3.09e-01
RAS signaling downstream of NF1 loss-of-function variants	7	3.19e-01	4.23e-01	0.37600	2.23e-01	3.02e-01	3.06e-01	1.66e-01
Nef Mediated CD4 Down-regulation	9	1.01e-01	1.79e-01	0.37500	-3.73e-01	4.55e-02	5.29e-02	8.13e-01
MECP2 regulates neuronal receptors and channels	13	1.26e-01	2.12e-01	0.37400	2.78e-01	2.51e-01	8.27e-02	1.17e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	1.08e-01	1.88e-01	0.37400	-3.22e-02	3.73e-01	8.67e-01	5.27e-02
Noncanonical activation of NOTCH3	8	1.41e-01	2.30e-01	0.37400	-3.73e-01	2.59e-02	6.75e-02	8.99e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	1.49e-02	3.94e-02	0.37400	-3.67e-01	7.24e-02	1.10e-02	6.16e-01
Metabolism of nucleotides	85	9.73e-08	8.23e-07	0.37300	-3.56e-01	-1.11e-01	1.33e-08	7.63e-02
DNA Damage/Telomere Stress Induced Senescence	42	6.93e-06	4.41e-05	0.37300	-3.49e-01	1.32e-01	8.98e-05	1.38e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	3.48e-02	7.92e-02	0.37300	2.95e-01	-2.28e-01	9.01e-02	1.91e-01
PTK6 promotes HIF1A stabilization	6	3.89e-01	4.90e-01	0.37200	2.57e-01	2.69e-01	2.76e-01	2.53e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	2.80e-01	3.88e-01	0.37200	1.33e-01	3.48e-01	5.43e-01	1.11e-01
Platelet calcium homeostasis	22	5.93e-03	1.82e-02	0.37100	-7.97e-03	3.71e-01	9.48e-01	2.62e-03
PI3K events in ERBB2 signaling	11	1.54e-01	2.45e-01	0.37100	3.30e-01	1.68e-01	5.79e-02	3.34e-01
Peroxisomal protein import	58	5.73e-05	3.11e-04	0.37000	-3.28e-01	-1.71e-01	1.53e-05	2.40e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	2.46e-01	3.50e-01	0.37000	2.76e-01	2.46e-01	1.52e-01	2.00e-01
Synthesis of GDP-mannose	6	2.81e-01	3.89e-01	0.37000	-3.67e-01	-4.29e-02	1.19e-01	8.56e-01
Cytochrome c-mediated apoptotic response	13	1.04e-01	1.82e-01	0.36900	-3.39e-01	-1.47e-01	3.45e-02	3.59e-01
Role of phospholipids in phagocytosis	87	1.41e-11	1.89e-10	0.36900	-3.27e-01	1.71e-01	1.36e-07	5.88e-03
G2/M Checkpoints	126	1.51e-14	2.81e-13	0.36900	-3.63e-01	6.66e-02	2.01e-12	1.97e-01
Antimicrobial peptides	33	1.09e-04	5.55e-04	0.36800	-1.33e-01	3.44e-01	1.86e-01	6.35e-04
Activation of the pre-replicative complex	32	4.61e-03	1.48e-02	0.36700	-3.30e-01	-1.61e-01	1.23e-03	1.14e-01
Signaling by EGFR	47	6.13e-05	3.29e-04	0.36700	4.83e-02	3.64e-01	5.67e-01	1.57e-05
Phase 0 - rapid depolarisation	22	3.41e-02	7.81e-02	0.36700	2.36e-01	2.81e-01	5.58e-02	2.25e-02
Initiation of Nuclear Envelope (NE) Reformation	19	3.71e-03	1.23e-02	0.36600	-2.89e-01	2.24e-01	2.89e-02	9.04e-02
Collagen degradation	41	1.06e-03	4.22e-03	0.36600	1.61e-01	3.29e-01	7.49e-02	2.66e-04
N-glycan antennae elongation in the medial/trans-Golgi	20	3.47e-03	1.17e-02	0.36600	-1.69e-01	3.24e-01	1.91e-01	1.20e-02
eNOS activation	10	1.78e-01	2.73e-01	0.36600	-3.38e-01	-1.41e-01	6.46e-02	4.41e-01
Erythropoietin activates Phospholipase C gamma (PLCG)	6	3.80e-01	4.81e-01	0.36500	1.81e-01	3.17e-01	4.44e-01	1.78e-01
Aryl hydrocarbon receptor signalling	6	3.67e-01	4.70e-01	0.36500	-3.29e-01	-1.57e-01	1.62e-01	5.04e-01
Lipophagy	7	2.45e-01	3.49e-01	0.36500	-3.61e-01	-5.56e-02	9.85e-02	7.99e-01
Voltage gated Potassium channels	25	2.27e-02	5.57e-02	0.36500	2.76e-01	2.38e-01	1.67e-02	3.96e-02
Regulation of MECP2 expression and activity	28	7.79e-03	2.30e-02	0.36500	3.39e-01	1.33e-01	1.89e-03	2.22e-01
ER-Phagosome pathway	74	1.74e-07	1.39e-06	0.36400	-3.63e-01	-2.87e-02	6.56e-08	6.69e-01
Nef and signal transduction	8	2.55e-01	3.60e-01	0.36300	3.36e-01	1.37e-01	9.98e-02	5.01e-01
Synthesis of 15-eicosatetraenoic acid derivatives	6	4.09e-01	5.08e-01	0.36300	-2.61e-01	-2.52e-01	2.68e-01	2.85e-01
Biosynthesis of E-series 18(S)-resolvins	5	4.10e-01	5.08e-01	0.36200	1.10e-01	3.45e-01	6.71e-01	1.82e-01
Selective autophagy	77	3.87e-07	2.95e-06	0.36100	-3.55e-01	-6.65e-02	7.46e-08	3.13e-01
RUNX3 regulates p14-ARF	10	2.28e-01	3.31e-01	0.36100	2.39e-01	2.70e-01	1.90e-01	1.40e-01
mRNA 3’-end processing	57	2.23e-04	1.06e-03	0.36000	-2.73e-01	-2.35e-01	3.68e-04	2.13e-03
Diseases of programmed cell death	58	6.26e-06	4.02e-05	0.36000	-3.59e-01	-2.60e-02	2.22e-06	7.32e-01
G1/S Transition	120	1.01e-12	1.54e-11	0.36000	-3.58e-01	3.64e-02	1.19e-11	4.91e-01
Signaling by NOTCH4	68	4.67e-08	4.15e-07	0.36000	-3.50e-01	8.39e-02	5.88e-07	2.32e-01
Interactions of Vpr with host cellular proteins	37	1.33e-03	5.12e-03	0.36000	-1.01e-01	-3.45e-01	2.87e-01	2.76e-04
Triglyceride biosynthesis	9	1.76e-01	2.71e-01	0.36000	3.54e-01	6.09e-02	6.56e-02	7.52e-01
Wax and plasmalogen biosynthesis	5	2.99e-01	4.08e-01	0.35900	-3.53e-01	6.67e-02	1.71e-01	7.96e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	3.29e-01	4.32e-01	0.35800	7.84e-02	3.50e-01	7.40e-01	1.38e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	3.29e-01	4.32e-01	0.35800	7.84e-02	3.50e-01	7.40e-01	1.38e-01
mRNA Editing	8	3.00e-01	4.09e-01	0.35800	1.99e-01	2.98e-01	3.30e-01	1.45e-01
HIV Transcription Initiation	45	5.08e-04	2.23e-03	0.35800	-3.35e-01	-1.27e-01	1.01e-04	1.42e-01
RNA Polymerase II HIV Promoter Escape	45	5.08e-04	2.23e-03	0.35800	-3.35e-01	-1.27e-01	1.01e-04	1.42e-01
RNA Polymerase II Promoter Escape	45	5.08e-04	2.23e-03	0.35800	-3.35e-01	-1.27e-01	1.01e-04	1.42e-01
RNA Polymerase II Transcription Initiation	45	5.08e-04	2.23e-03	0.35800	-3.35e-01	-1.27e-01	1.01e-04	1.42e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	5.08e-04	2.23e-03	0.35800	-3.35e-01	-1.27e-01	1.01e-04	1.42e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	5.08e-04	2.23e-03	0.35800	-3.35e-01	-1.27e-01	1.01e-04	1.42e-01
ARMS-mediated activation	6	3.16e-01	4.21e-01	0.35800	5.87e-02	3.53e-01	8.03e-01	1.34e-01
COPI-independent Golgi-to-ER retrograde traffic	45	3.12e-06	2.12e-05	0.35700	-2.32e-01	2.72e-01	7.09e-03	1.59e-03
Receptor Mediated Mitophagy	11	8.51e-02	1.56e-01	0.35700	-3.56e-01	2.76e-02	4.09e-02	8.74e-01
Signal transduction by L1	20	3.93e-03	1.30e-02	0.35700	-2.96e-01	2.00e-01	2.21e-02	1.21e-01
Activated NTRK2 signals through FRS2 and FRS3	8	2.69e-01	3.75e-01	0.35700	1.37e-01	3.29e-01	5.01e-01	1.07e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	14	2.03e-02	5.07e-02	0.35600	2.84e-01	-2.15e-01	6.53e-02	1.64e-01
Cyclin A:Cdk2-associated events at S phase entry	75	1.99e-08	1.89e-07	0.35500	-3.49e-01	6.79e-02	1.74e-07	3.09e-01
Downregulation of ERBB2:ERBB3 signaling	12	1.27e-01	2.12e-01	0.35500	-1.07e-01	-3.39e-01	5.22e-01	4.20e-02
Formation of the beta-catenin:TCF transactivating complex	44	6.21e-05	3.32e-04	0.35500	-2.49e-02	3.54e-01	7.75e-01	4.81e-05
Glycosphingolipid catabolism	31	6.43e-03	1.96e-02	0.35400	-3.28e-01	-1.33e-01	1.55e-03	1.99e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	3.31e-01	4.33e-01	0.35400	3.21e-01	1.51e-01	1.42e-01	4.90e-01
RHO GTPases Activate NADPH Oxidases	21	2.93e-02	6.92e-02	0.35400	1.15e-01	3.35e-01	3.64e-01	7.91e-03
Signaling by CSF1 (M-CSF) in myeloid cells	30	1.42e-02	3.80e-02	0.35400	2.44e-01	2.56e-01	2.09e-02	1.51e-02
Azathioprine ADME	20	1.17e-02	3.26e-02	0.35400	-3.52e-01	3.50e-02	6.45e-03	7.86e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	3.14e-01	4.20e-01	0.35400	3.32e-01	1.22e-01	1.29e-01	5.75e-01
Ribavirin ADME	11	6.88e-02	1.32e-01	0.35300	-3.40e-01	9.56e-02	5.12e-02	5.83e-01
Heme signaling	45	1.07e-03	4.25e-03	0.35200	3.12e-01	1.64e-01	2.97e-04	5.77e-02
Signaling by the B Cell Receptor (BCR)	149	1.17e-17	2.93e-16	0.35200	-3.10e-01	1.66e-01	6.29e-11	4.61e-04
Miro GTPase Cycle	8	1.12e-01	1.94e-01	0.35200	-2.41e-01	2.56e-01	2.37e-01	2.10e-01
PTK6 Regulates Cell Cycle	6	2.28e-01	3.31e-01	0.35100	-3.33e-01	1.12e-01	1.58e-01	6.36e-01
Maturation of hRSV A proteins	13	5.16e-02	1.06e-01	0.35100	-3.46e-01	5.89e-02	3.08e-02	7.13e-01
ROBO receptors bind AKAP5	7	3.75e-01	4.78e-01	0.35000	2.29e-01	2.65e-01	2.94e-01	2.24e-01
Keratan sulfate biosynthesis	19	3.82e-02	8.48e-02	0.35000	9.14e-02	3.38e-01	4.90e-01	1.07e-02
RNA Polymerase I Transcription Initiation	47	1.47e-03	5.53e-03	0.34900	-2.31e-01	-2.63e-01	6.22e-03	1.84e-03
Incretin synthesis, secretion, and inactivation	14	3.67e-02	8.26e-02	0.34900	-3.38e-01	8.71e-02	2.84e-02	5.72e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	3.67e-02	8.26e-02	0.34900	-3.38e-01	8.71e-02	2.84e-02	5.72e-01
Kinesins	51	1.06e-05	6.60e-05	0.34900	-5.60e-02	3.45e-01	4.89e-01	2.05e-05
Erythropoietin activates RAS	13	1.45e-01	2.33e-01	0.34900	1.66e-01	3.07e-01	3.00e-01	5.54e-02
TRP channels	21	3.15e-02	7.31e-02	0.34900	3.31e-01	1.08e-01	8.54e-03	3.91e-01
PI-3K cascade:FGFR4	11	2.20e-01	3.23e-01	0.34900	2.51e-01	2.42e-01	1.50e-01	1.64e-01
Digestion and absorption	7	1.64e-01	2.57e-01	0.34800	-1.69e-01	3.04e-01	4.38e-01	1.64e-01
Laminin interactions	25	1.69e-02	4.33e-02	0.34800	1.09e-01	3.30e-01	3.45e-01	4.29e-03
PI-3K cascade:FGFR3	10	2.53e-01	3.58e-01	0.34800	2.29e-01	2.62e-01	2.11e-01	1.52e-01
Signaling by BMP	23	2.55e-02	6.14e-02	0.34700	3.26e-01	1.21e-01	6.83e-03	3.17e-01
Transcription of the HIV genome	67	3.11e-05	1.81e-04	0.34700	-3.20e-01	-1.34e-01	5.84e-06	5.69e-02
Cyclin A/B1/B2 associated events during G2/M transition	25	1.33e-03	5.11e-03	0.34700	-2.72e-01	2.15e-01	1.84e-02	6.24e-02
Plasma lipoprotein assembly	10	2.10e-01	3.12e-01	0.34700	1.31e-01	3.21e-01	4.72e-01	7.84e-02
Glycogen synthesis	11	1.27e-01	2.12e-01	0.34700	-3.45e-01	-3.66e-02	4.76e-02	8.33e-01
Synthesis of PIPs at the plasma membrane	52	8.00e-04	3.33e-03	0.34700	2.67e-01	2.21e-01	8.49e-04	5.93e-03
G0 and Early G1	27	1.11e-03	4.38e-03	0.34600	-1.53e-01	3.11e-01	1.69e-01	5.17e-03
Growth hormone receptor signaling	20	3.71e-02	8.32e-02	0.34600	9.85e-02	3.31e-01	4.46e-01	1.03e-02
Myoclonic epilepsy of Lafora	8	3.07e-01	4.15e-01	0.34600	-3.08e-01	-1.56e-01	1.31e-01	4.44e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	2.51e-03	8.91e-03	0.34500	-3.45e-01	1.62e-03	1.07e-03	9.88e-01
Glutathione synthesis and recycling	10	7.66e-02	1.43e-01	0.34400	-2.86e-01	1.91e-01	1.17e-01	2.97e-01
Elevation of cytosolic Ca2+ levels	13	6.45e-02	1.25e-01	0.34400	-3.55e-02	3.42e-01	8.25e-01	3.28e-02
Senescence-Associated Secretory Phenotype (SASP)	64	5.60e-07	4.15e-06	0.34100	-3.31e-01	8.45e-02	4.68e-06	2.42e-01
Formation of axial mesoderm	6	4.51e-01	5.48e-01	0.34100	2.55e-01	2.28e-01	2.80e-01	3.34e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	3.82e-02	8.48e-02	0.34100	-1.80e-01	2.90e-01	2.62e-01	7.00e-02
Paracetamol ADME	19	1.68e-02	4.32e-02	0.34100	-3.36e-01	5.61e-02	1.11e-02	6.72e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.26e-01	3.29e-01	0.34100	1.96e-01	2.79e-01	2.60e-01	1.10e-01
GABA receptor activation	35	9.30e-03	2.68e-02	0.34000	2.02e-01	2.74e-01	3.87e-02	5.10e-03
Proton-coupled monocarboxylate transport	6	2.77e-01	3.85e-01	0.34000	-5.63e-02	3.35e-01	8.11e-01	1.55e-01
Uptake and function of anthrax toxins	10	1.43e-01	2.32e-01	0.34000	-3.04e-03	3.40e-01	9.87e-01	6.27e-02
Nef Mediated CD8 Down-regulation	7	1.74e-01	2.69e-01	0.34000	-2.87e-01	1.83e-01	1.89e-01	4.03e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	74	2.14e-07	1.68e-06	0.33900	-4.35e-02	3.36e-01	5.18e-01	5.72e-07
Aggrephagy	34	4.19e-04	1.90e-03	0.33900	-3.22e-01	1.06e-01	1.18e-03	2.83e-01
Mitochondrial Uncoupling	6	4.06e-01	5.06e-01	0.33800	-1.21e-01	-3.16e-01	6.09e-01	1.81e-01
DCC mediated attractive signaling	13	4.93e-02	1.03e-01	0.33700	-3.15e-01	1.21e-01	4.93e-02	4.51e-01
Plasma lipoprotein remodeling	18	1.43e-02	3.82e-02	0.33700	-1.37e-01	3.08e-01	3.13e-01	2.37e-02
Regulation of BACH1 activity	11	2.26e-01	3.29e-01	0.33600	-2.88e-01	-1.73e-01	9.76e-02	3.21e-01
Fibronectin matrix formation	6	2.40e-01	3.44e-01	0.33600	-1.51e-01	3.00e-01	5.23e-01	2.03e-01
Chondroitin sulfate biosynthesis	12	2.15e-01	3.18e-01	0.33600	2.52e-01	2.22e-01	1.31e-01	1.83e-01
Constitutive Signaling by EGFRvIII	14	1.66e-01	2.59e-01	0.33600	2.19e-01	2.54e-01	1.56e-01	9.94e-02
Signaling by EGFRvIII in Cancer	14	1.66e-01	2.59e-01	0.33600	2.19e-01	2.54e-01	1.56e-01	9.94e-02
MET activates RAP1 and RAC1	10	2.34e-01	3.37e-01	0.33600	1.29e-01	3.10e-01	4.81e-01	8.98e-02
Dissolution of Fibrin Clot	12	5.08e-02	1.05e-01	0.33500	-2.24e-01	2.49e-01	1.80e-01	1.35e-01
SARS-CoV-1 Infection	137	5.03e-09	5.06e-08	0.33500	-3.01e-01	-1.46e-01	1.10e-09	3.19e-03
Anti-inflammatory response favouring Leishmania parasite infection	130	1.17e-14	2.21e-13	0.33500	-2.30e-01	2.43e-01	5.68e-06	1.78e-06
Leishmania parasite growth and survival	130	1.17e-14	2.21e-13	0.33500	-2.30e-01	2.43e-01	5.68e-06	1.78e-06
ABC-family proteins mediated transport	81	2.15e-08	2.02e-07	0.33400	-3.21e-01	9.24e-02	5.94e-07	1.51e-01
Retinoid metabolism and transport	23	2.33e-02	5.69e-02	0.33300	6.36e-02	3.27e-01	5.98e-01	6.58e-03
Transcriptional regulation of granulopoiesis	44	4.49e-05	2.51e-04	0.33300	-1.25e-01	3.09e-01	1.51e-01	3.90e-04
Diseases of hemostasis	13	4.20e-02	9.11e-02	0.33300	-2.63e-01	2.05e-01	1.01e-01	2.01e-01
Triglyceride catabolism	15	7.26e-02	1.38e-01	0.33300	2.90e-02	3.31e-01	8.46e-01	2.62e-02
NPAS4 regulates expression of target genes	16	6.73e-02	1.30e-01	0.33300	4.65e-02	3.29e-01	7.48e-01	2.25e-02
Lysosome Vesicle Biogenesis	32	3.40e-03	1.15e-02	0.33200	-3.31e-01	-1.88e-02	1.17e-03	8.54e-01
Regulation of signaling by CBL	22	6.23e-02	1.22e-01	0.33200	2.58e-01	2.08e-01	3.59e-02	9.06e-02
Gap junction trafficking	27	2.83e-03	9.77e-03	0.33100	-9.95e-02	3.16e-01	3.71e-01	4.50e-03
Late endosomal microautophagy	30	1.41e-03	5.35e-03	0.33100	-3.14e-01	1.05e-01	2.90e-03	3.21e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.27e-04	6.30e-04	0.33100	-2.12e-01	-2.54e-01	1.83e-03	1.98e-04
Pyrimidine catabolism	9	1.16e-01	1.99e-01	0.33000	-1.96e-01	2.66e-01	3.08e-01	1.67e-01
Regulation of TP53 Activity through Association with Co-factors	11	7.10e-02	1.35e-01	0.33000	2.32e-01	-2.34e-01	1.82e-01	1.79e-01
Assembly of active LPL and LIPC lipase complexes	10	9.50e-02	1.69e-01	0.32900	-1.82e-01	2.75e-01	3.20e-01	1.33e-01
Nuclear Receptor transcription pathway	38	6.25e-03	1.91e-02	0.32900	2.93e-01	1.51e-01	1.80e-03	1.07e-01
FCGR3A-mediated IL10 synthesis	98	7.78e-11	9.40e-10	0.32900	-2.54e-01	2.09e-01	1.38e-05	3.54e-04
SHC1 events in ERBB4 signaling	10	2.94e-01	4.02e-01	0.32900	2.39e-01	2.26e-01	1.91e-01	2.16e-01
Serine biosynthesis	8	2.64e-01	3.69e-01	0.32800	3.88e-02	3.26e-01	8.49e-01	1.10e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	1.07e-01	1.87e-01	0.32800	5.88e-02	3.23e-01	7.03e-01	3.65e-02
Hydrolysis of LPC	8	2.00e-01	3.00e-01	0.32800	-6.02e-02	3.22e-01	7.68e-01	1.14e-01
Cholesterol biosynthesis	26	2.34e-03	8.37e-03	0.32800	-2.75e-01	1.79e-01	1.53e-02	1.14e-01
Organic cation transport	8	3.16e-01	4.21e-01	0.32800	1.08e-01	3.10e-01	5.98e-01	1.29e-01
Organic cation/anion/zwitterion transport	8	3.16e-01	4.21e-01	0.32800	1.08e-01	3.10e-01	5.98e-01	1.29e-01
Mitotic G1 phase and G1/S transition	138	4.60e-13	7.36e-12	0.32700	-3.17e-01	8.01e-02	1.19e-10	1.04e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	29	5.06e-03	1.61e-02	0.32700	-3.27e-01	9.04e-03	2.30e-03	9.33e-01
MyD88 deficiency (TLR2/4)	14	1.64e-01	2.57e-01	0.32700	2.84e-01	1.62e-01	6.60e-02	2.95e-01
MAP2K and MAPK activation	36	2.16e-04	1.03e-03	0.32600	-2.34e-01	2.27e-01	1.52e-02	1.86e-02
Ras activation upon Ca2+ influx through NMDA receptor	15	1.05e-01	1.83e-01	0.32500	3.16e-01	7.84e-02	3.41e-02	5.99e-01
Fanconi Anemia Pathway	36	1.29e-02	3.51e-02	0.32400	-1.96e-01	-2.58e-01	4.16e-02	7.45e-03
Platelet Aggregation (Plug Formation)	28	1.67e-03	6.21e-03	0.32400	-2.67e-01	1.84e-01	1.45e-02	9.27e-02
Synthesis of 12-eicosatetraenoic acid derivatives	6	4.51e-01	5.48e-01	0.32300	-2.95e-01	-1.33e-01	2.11e-01	5.72e-01
Host Interactions of HIV factors	118	1.01e-07	8.49e-07	0.32300	-3.02e-01	-1.16e-01	1.47e-08	2.98e-02
Methylation	13	2.12e-01	3.15e-01	0.32300	-2.48e-01	-2.07e-01	1.21e-01	1.96e-01
Advanced glycosylation endproduct receptor signaling	12	1.28e-01	2.13e-01	0.32300	-3.23e-01	-8.48e-03	5.30e-02	9.59e-01
Positive epigenetic regulation of rRNA expression	60	1.10e-04	5.60e-04	0.32200	-3.16e-01	-6.40e-02	2.29e-05	3.91e-01
FLT3 signaling in disease	27	3.71e-02	8.32e-02	0.32200	1.79e-01	2.68e-01	1.07e-01	1.59e-02
Chaperone Mediated Autophagy	20	1.66e-02	4.28e-02	0.32200	-3.09e-01	9.32e-02	1.69e-02	4.70e-01
Activation of caspases through apoptosome-mediated cleavage	6	2.70e-01	3.76e-01	0.32200	-2.87e-01	1.46e-01	2.23e-01	5.37e-01
HIV Infection	213	1.32e-13	2.25e-12	0.32200	-3.06e-01	-9.89e-02	1.35e-14	1.29e-02
Viral Messenger RNA Synthesis	44	5.04e-03	1.61e-02	0.32200	-1.85e-01	-2.63e-01	3.34e-02	2.57e-03
Cell surface interactions at the vascular wall	169	2.45e-17	5.96e-16	0.32100	-2.49e-01	2.03e-01	2.32e-08	5.11e-06
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	2.93e-01	4.02e-01	0.32100	-3.01e-01	-1.11e-01	1.18e-01	5.63e-01
RHO GTPases Activate WASPs and WAVEs	35	4.26e-04	1.92e-03	0.32100	-1.70e-01	2.72e-01	8.11e-02	5.44e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	5.36e-02	1.09e-01	0.32000	-6.74e-04	3.20e-01	9.96e-01	2.21e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	5.36e-02	1.09e-01	0.32000	-6.74e-04	3.20e-01	9.96e-01	2.21e-02
Vpr-mediated nuclear import of PICs	34	5.58e-03	1.75e-02	0.32000	-5.62e-02	-3.16e-01	5.71e-01	1.45e-03
Inwardly rectifying K+ channels	22	3.61e-02	8.14e-02	0.32000	5.98e-02	3.14e-01	6.28e-01	1.07e-02
Response of EIF2AK1 (HRI) to heme deficiency	14	5.34e-02	1.09e-01	0.32000	-2.97e-01	1.19e-01	5.45e-02	4.41e-01
MET activates RAS signaling	10	3.13e-01	4.20e-01	0.32000	2.12e-01	2.39e-01	2.46e-01	1.90e-01
PKA activation in glucagon signalling	14	1.89e-01	2.86e-01	0.31900	1.82e-01	2.62e-01	2.39e-01	8.93e-02
Transport of vitamins, nucleosides, and related molecules	31	1.80e-02	4.59e-02	0.31900	-2.92e-01	-1.29e-01	4.92e-03	2.13e-01
Phosphate bond hydrolysis by NTPDase proteins	5	4.24e-01	5.23e-01	0.31900	3.03e-03	-3.19e-01	9.91e-01	2.17e-01
Prolonged ERK activation events	13	8.96e-02	1.62e-01	0.31900	-4.46e-02	3.16e-01	7.80e-01	4.86e-02
Activation of GABAB receptors	29	3.26e-02	7.52e-02	0.31900	1.86e-01	2.59e-01	8.27e-02	1.58e-02
GABA B receptor activation	29	3.26e-02	7.52e-02	0.31900	1.86e-01	2.59e-01	8.27e-02	1.58e-02
NF-kB is activated and signals survival	12	1.84e-01	2.80e-01	0.31900	-3.07e-01	-8.78e-02	6.59e-02	5.99e-01
Metabolism of Angiotensinogen to Angiotensins	12	2.47e-01	3.51e-01	0.31900	2.00e-01	2.48e-01	2.30e-01	1.37e-01
Post-translational protein phosphorylation	67	3.92e-06	2.64e-05	0.31900	-4.78e-02	3.15e-01	4.99e-01	8.18e-06
Transport of Mature Transcript to Cytoplasm	81	9.25e-05	4.78e-04	0.31900	-2.29e-01	-2.21e-01	3.66e-04	5.72e-04
Maturation of spike protein 9694548	35	4.06e-04	1.85e-03	0.31800	-2.41e-01	2.07e-01	1.36e-02	3.37e-02
HIV Life Cycle	144	2.53e-08	2.36e-07	0.31700	-2.77e-01	-1.55e-01	9.65e-09	1.31e-03
Activation of NOXA and translocation to mitochondria	5	3.33e-01	4.35e-01	0.31700	2.58e-01	-1.85e-01	3.19e-01	4.73e-01
G1/S-Specific Transcription	29	1.64e-03	6.09e-03	0.31700	-2.42e-01	2.04e-01	2.39e-02	5.72e-02
E3 ubiquitin ligases ubiquitinate target proteins	51	1.21e-04	6.07e-04	0.31700	-3.15e-01	2.78e-02	9.78e-05	7.32e-01
ABC transporters in lipid homeostasis	14	7.87e-02	1.47e-01	0.31600	3.13e-01	-4.23e-02	4.24e-02	7.84e-01
UCH proteinases	73	7.99e-07	5.83e-06	0.31600	-3.06e-01	7.75e-02	5.98e-06	2.52e-01
RUNX3 Regulates Immune Response and Cell Migration	5	4.98e-01	5.90e-01	0.31600	3.05e-01	8.32e-02	2.38e-01	7.47e-01
Signaling by ERBB2 KD Mutants	20	9.98e-02	1.76e-01	0.31500	2.55e-01	1.86e-01	4.86e-02	1.50e-01
Formation of Fibrin Clot (Clotting Cascade)	26	3.99e-03	1.31e-02	0.31500	-1.57e-01	2.73e-01	1.66e-01	1.58e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	2.86e-03	9.85e-03	0.31500	-3.15e-01	3.97e-03	1.26e-03	9.68e-01
Signaling by high-kinase activity BRAF mutants	33	7.17e-04	3.01e-03	0.31500	-2.27e-01	2.19e-01	2.43e-02	2.96e-02
Aspirin ADME	13	8.11e-02	1.50e-01	0.31500	-8.35e-02	3.04e-01	6.02e-01	5.81e-02
S Phase	150	8.56e-11	1.03e-09	0.31500	-3.13e-01	-3.08e-02	3.47e-11	5.16e-01
Na+/Cl- dependent neurotransmitter transporters	7	4.52e-01	5.49e-01	0.31500	1.99e-01	2.43e-01	3.61e-01	2.65e-01
PI-3K cascade:FGFR2	13	2.30e-01	3.33e-01	0.31400	2.44e-01	1.98e-01	1.28e-01	2.16e-01
Diseases of Mismatch Repair (MMR)	5	4.37e-01	5.35e-01	0.31400	-3.14e-01	2.46e-03	2.24e-01	9.92e-01
Regulation of KIT signaling	15	1.73e-01	2.67e-01	0.31300	1.63e-01	2.67e-01	2.75e-01	7.31e-02
Sema4D induced cell migration and growth-cone collapse	19	2.14e-02	5.30e-02	0.31300	-1.24e-01	2.87e-01	3.50e-01	3.01e-02
Formation of apoptosome	11	2.82e-01	3.89e-01	0.31300	-2.60e-01	-1.73e-01	1.35e-01	3.19e-01
Regulation of the apoptosome activity	11	2.82e-01	3.89e-01	0.31300	-2.60e-01	-1.73e-01	1.35e-01	3.19e-01
Activation of BAD and translocation to mitochondria	15	8.70e-02	1.58e-01	0.31300	-3.13e-01	-2.29e-03	3.60e-02	9.88e-01
Pregnenolone biosynthesis	10	2.54e-01	3.59e-01	0.31200	-3.02e-01	-7.95e-02	9.84e-02	6.63e-01
Retrograde neurotrophin signalling	12	9.98e-02	1.76e-01	0.31200	-2.98e-01	9.07e-02	7.34e-02	5.87e-01
Frs2-mediated activation	11	1.14e-01	1.97e-01	0.31200	-1.08e-01	2.92e-01	5.33e-01	9.31e-02
Sodium/Calcium exchangers	9	1.44e-01	2.33e-01	0.31200	-2.29e-01	2.12e-01	2.34e-01	2.72e-01
VxPx cargo-targeting to cilium	19	1.13e-01	1.95e-01	0.31200	1.69e-01	2.62e-01	2.03e-01	4.81e-02
Diseases associated with glycosylation precursor biosynthesis	15	1.27e-01	2.12e-01	0.31200	-3.02e-01	-7.65e-02	4.29e-02	6.08e-01
Long-term potentiation	14	5.24e-02	1.07e-01	0.31100	1.77e-01	-2.56e-01	2.53e-01	9.72e-02
Formation of paraxial mesoderm	52	2.84e-05	1.66e-04	0.31100	-2.81e-01	1.32e-01	4.56e-04	9.86e-02
ADP signalling through P2Y purinoceptor 1	21	2.71e-02	6.46e-02	0.31100	-3.13e-02	3.09e-01	8.04e-01	1.42e-02
Gap junction trafficking and regulation	29	4.38e-03	1.42e-02	0.31100	-8.03e-02	3.00e-01	4.54e-01	5.17e-03
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	3.31e-01	4.33e-01	0.31000	3.10e-01	9.41e-03	1.55e-01	9.66e-01
Downstream signaling of activated FGFR4	18	1.39e-01	2.28e-01	0.31000	2.34e-01	2.04e-01	8.62e-02	1.33e-01
KEAP1-NFE2L2 pathway	106	2.03e-10	2.37e-09	0.31000	-2.45e-01	1.90e-01	1.26e-05	7.41e-04
Late Phase of HIV Life Cycle	131	1.60e-07	1.29e-06	0.31000	-2.79e-01	-1.34e-01	3.40e-08	8.26e-03
Fcgamma receptor (FCGR) dependent phagocytosis	146	4.31e-14	7.81e-13	0.30900	-2.14e-01	2.23e-01	7.74e-06	3.27e-06
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	6.87e-02	1.32e-01	0.30900	-2.65e-01	1.60e-01	9.84e-02	3.17e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	1.97e-03	7.18e-03	0.30900	-2.88e-01	1.13e-01	4.85e-03	2.70e-01
Recycling pathway of L1	40	2.22e-04	1.06e-03	0.30900	-2.06e-01	2.30e-01	2.40e-02	1.20e-02
Macroautophagy	128	6.68e-08	5.80e-07	0.30800	-2.94e-01	-9.30e-02	9.01e-09	6.94e-02
RHOBTB1 GTPase cycle	23	1.24e-02	3.40e-02	0.30700	-2.89e-01	1.05e-01	1.64e-02	3.83e-01
SARS-CoV-2-host interactions	181	4.35e-09	4.40e-08	0.30700	-2.27e-01	-2.07e-01	1.33e-07	1.63e-06
Sema4D in semaphorin signaling	22	1.20e-02	3.31e-02	0.30700	-1.50e-01	2.68e-01	2.24e-01	2.95e-02
Cell Cycle Checkpoints	245	3.95e-18	1.07e-16	0.30700	-3.06e-01	2.30e-02	1.56e-16	5.36e-01
O-glycosylation of TSR domain-containing proteins	25	1.68e-02	4.32e-02	0.30700	3.06e-01	-1.83e-02	8.05e-03	8.74e-01
Chemokine receptors bind chemokines	38	4.36e-03	1.41e-02	0.30700	4.34e-02	3.04e-01	6.44e-01	1.20e-03
Activation of RAC1 downstream of NMDARs	7	2.37e-01	3.40e-01	0.30700	-2.48e-01	1.81e-01	2.57e-01	4.07e-01
RHO GTPases activate PAKs	20	4.58e-02	9.74e-02	0.30600	8.73e-03	3.06e-01	9.46e-01	1.77e-02
Downstream signaling of activated FGFR3	17	1.64e-01	2.57e-01	0.30600	2.20e-01	2.14e-01	1.17e-01	1.27e-01
Spry regulation of FGF signaling	16	5.24e-02	1.07e-01	0.30600	-2.94e-01	8.57e-02	4.17e-02	5.53e-01
Germ layer formation at gastrulation	9	2.58e-01	3.63e-01	0.30600	3.06e-01	1.94e-02	1.12e-01	9.20e-01
SMAC (DIABLO) binds to IAPs	7	3.29e-01	4.32e-01	0.30600	-3.06e-01	5.76e-03	1.61e-01	9.79e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	3.29e-01	4.32e-01	0.30600	-3.06e-01	5.76e-03	1.61e-01	9.79e-01
SMAC, XIAP-regulated apoptotic response	7	3.29e-01	4.32e-01	0.30600	-3.06e-01	5.76e-03	1.61e-01	9.79e-01
Signaling by FGFR3 in disease	14	2.27e-01	3.30e-01	0.30600	2.20e-01	2.12e-01	1.54e-01	1.69e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	1.95e-02	4.90e-02	0.30600	-2.89e-01	1.00e-01	2.19e-02	4.28e-01
Neurodegenerative Diseases	21	1.95e-02	4.90e-02	0.30600	-2.89e-01	1.00e-01	2.19e-02	4.28e-01
NS1 Mediated Effects on Host Pathways	40	3.50e-03	1.17e-02	0.30600	-4.51e-02	-3.02e-01	6.22e-01	9.41e-04
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	4.69e-01	5.65e-01	0.30500	3.05e-01	1.32e-02	2.38e-01	9.59e-01
Fc epsilon receptor (FCERI) signaling	178	3.10e-16	6.93e-15	0.30500	-2.54e-01	1.69e-01	5.27e-09	9.90e-05
Aflatoxin activation and detoxification	14	9.47e-02	1.69e-01	0.30500	-3.02e-01	3.97e-02	5.03e-02	7.97e-01
Deadenylation-dependent mRNA decay	50	5.01e-03	1.60e-02	0.30500	-2.35e-01	-1.94e-01	4.11e-03	1.74e-02
Beta-oxidation of pristanoyl-CoA	9	3.16e-01	4.21e-01	0.30400	-2.92e-01	-8.59e-02	1.29e-01	6.56e-01
Gluconeogenesis	19	2.04e-02	5.09e-02	0.30400	-2.25e-01	2.05e-01	8.93e-02	1.22e-01
Transcriptional regulation by small RNAs	61	7.52e-04	3.16e-03	0.30400	-2.79e-01	-1.20e-01	1.65e-04	1.04e-01
Hyaluronan uptake and degradation	12	8.66e-02	1.58e-01	0.30400	-2.26e-01	2.03e-01	1.76e-01	2.23e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	2.45e-02	5.94e-02	0.30300	2.75e-01	1.26e-01	7.02e-03	2.16e-01
Postmitotic nuclear pore complex (NPC) reformation	27	5.63e-02	1.13e-01	0.30300	-1.75e-01	-2.47e-01	1.16e-01	2.63e-02
Downstream signal transduction	27	3.45e-02	7.87e-02	0.30300	9.16e-02	2.88e-01	4.10e-01	9.47e-03
Defective B3GALTL causes PpS	24	2.74e-02	6.51e-02	0.30200	3.02e-01	9.01e-03	1.04e-02	9.39e-01
Pyrimidine salvage	10	1.71e-01	2.65e-01	0.30100	-2.91e-01	7.80e-02	1.11e-01	6.69e-01
Activation of gene expression by SREBF (SREBP)	42	9.06e-03	2.62e-02	0.30100	1.37e-01	2.68e-01	1.25e-01	2.62e-03
Reversal of alkylation damage by DNA dioxygenases	7	4.16e-01	5.15e-01	0.30100	-2.89e-01	-8.47e-02	1.86e-01	6.98e-01
NOTCH4 Intracellular Domain Regulates Transcription	17	1.74e-01	2.68e-01	0.30100	2.23e-01	2.03e-01	1.12e-01	1.48e-01
Depolymerization of the Nuclear Lamina	15	5.69e-02	1.14e-01	0.30100	-1.39e-01	2.67e-01	3.52e-01	7.39e-02
RHOC GTPase cycle	71	6.02e-05	3.24e-04	0.30000	4.26e-02	2.97e-01	5.35e-01	1.48e-05
SUMOylation of transcription factors	16	1.59e-01	2.50e-01	0.30000	-1.19e-01	-2.75e-01	4.09e-01	5.66e-02
MicroRNA (miRNA) biogenesis	24	8.07e-02	1.49e-01	0.30000	-2.46e-01	-1.71e-01	3.69e-02	1.46e-01
Signaling by NTRK3 (TRKC)	15	2.17e-01	3.20e-01	0.30000	2.13e-01	2.10e-01	1.53e-01	1.58e-01
Separation of Sister Chromatids	167	1.50e-12	2.24e-11	0.30000	-2.96e-01	4.35e-02	3.84e-11	3.32e-01
Signal amplification	28	5.83e-03	1.81e-02	0.29900	-1.14e-01	2.76e-01	2.95e-01	1.13e-02
Signaling by MST1	5	5.89e-01	6.73e-01	0.29900	-2.53e-01	-1.60e-01	3.28e-01	5.36e-01
Mitotic Anaphase	210	2.52e-15	5.33e-14	0.29800	-2.96e-01	3.88e-02	1.44e-13	3.33e-01
Signalling to ERKs	32	9.85e-03	2.82e-02	0.29800	1.33e-02	2.98e-01	8.96e-01	3.54e-03
Downstream signaling events of B Cell Receptor (BCR)	68	6.37e-06	4.08e-05	0.29800	-2.84e-01	9.08e-02	5.21e-05	1.95e-01
Transcriptional regulation of testis differentiation	5	4.27e-01	5.26e-01	0.29800	2.89e-01	-7.05e-02	2.63e-01	7.85e-01
Mitotic Metaphase and Anaphase	211	2.77e-15	5.72e-14	0.29700	-2.95e-01	3.78e-02	1.46e-13	3.44e-01
Syndecan interactions	23	1.18e-02	3.29e-02	0.29700	-2.44e-01	1.71e-01	4.31e-02	1.57e-01
Golgi-to-ER retrograde transport	123	4.48e-11	5.66e-10	0.29700	-1.86e-01	2.32e-01	3.58e-04	9.05e-06
PKA-mediated phosphorylation of CREB	17	1.80e-01	2.75e-01	0.29700	1.90e-01	2.28e-01	1.74e-01	1.03e-01
Trafficking of GluR2-containing AMPA receptors	11	1.17e-01	2.00e-01	0.29700	-1.99e-01	2.21e-01	2.54e-01	2.05e-01
Membrane binding and targetting of GAG proteins	13	2.15e-01	3.18e-01	0.29600	-2.81e-01	-9.30e-02	7.94e-02	5.61e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	2.15e-01	3.18e-01	0.29600	-2.81e-01	-9.30e-02	7.94e-02	5.61e-01
Degradation of beta-catenin by the destruction complex	72	1.71e-06	1.20e-05	0.29600	-2.64e-01	1.34e-01	1.09e-04	4.87e-02
Nucleotide catabolism	28	2.25e-02	5.55e-02	0.29500	-2.93e-01	-3.25e-02	7.20e-03	7.66e-01
IRAK1 recruits IKK complex	14	1.66e-01	2.59e-01	0.29500	-2.90e-01	-5.61e-02	6.05e-02	7.16e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	1.66e-01	2.59e-01	0.29500	-2.90e-01	-5.61e-02	6.05e-02	7.16e-01
Estrogen-stimulated signaling through PRKCZ	6	3.82e-01	4.83e-01	0.29500	-2.91e-01	4.67e-02	2.17e-01	8.43e-01
Respiratory syncytial virus (RSV) attachment and entry	17	1.72e-01	2.66e-01	0.29500	1.54e-01	2.52e-01	2.73e-01	7.26e-02
HDL remodeling	6	3.35e-01	4.37e-01	0.29500	-1.29e-01	2.65e-01	5.84e-01	2.61e-01
ZBP1(DAI) mediated induction of type I IFNs	20	1.32e-01	2.18e-01	0.29500	2.43e-01	1.67e-01	6.01e-02	1.97e-01
Signaling by cytosolic FGFR1 fusion mutants	18	1.70e-01	2.64e-01	0.29400	1.99e-01	2.17e-01	1.45e-01	1.11e-01
Transcriptional Regulation by MECP2	47	9.84e-03	2.82e-02	0.29400	2.25e-01	1.89e-01	7.70e-03	2.48e-02
IRAK4 deficiency (TLR2/4)	15	2.05e-01	3.06e-01	0.29400	2.59e-01	1.38e-01	8.19e-02	3.56e-01
Generation of second messenger molecules	38	2.05e-03	7.44e-03	0.29400	6.07e-02	-2.87e-01	5.18e-01	2.18e-03
Signaling by SCF-KIT	40	1.01e-02	2.89e-02	0.29300	9.72e-02	2.77e-01	2.88e-01	2.45e-03
Signaling by ERBB2 ECD mutants	15	2.32e-01	3.34e-01	0.29300	2.01e-01	2.14e-01	1.79e-01	1.52e-01
NrCAM interactions	6	3.30e-01	4.32e-01	0.29300	2.51e-01	-1.51e-01	2.87e-01	5.21e-01
L1CAM interactions	99	2.11e-07	1.66e-06	0.29300	-3.88e-02	2.90e-01	5.05e-01	5.90e-07
TRAIL signaling	8	2.57e-01	3.63e-01	0.29300	2.79e-01	-8.73e-02	1.71e-01	6.69e-01
Downstream signaling of activated FGFR2	20	1.40e-01	2.29e-01	0.29200	2.31e-01	1.79e-01	7.38e-02	1.65e-01
CD209 (DC-SIGN) signaling	20	5.82e-02	1.16e-01	0.29200	2.92e-01	2.71e-03	2.36e-02	9.83e-01
Glucagon signaling in metabolic regulation	26	4.87e-02	1.02e-01	0.29200	8.72e-02	2.78e-01	4.42e-01	1.40e-02
Downstream signaling of activated FGFR1	22	1.15e-01	1.98e-01	0.29200	2.33e-01	1.76e-01	5.85e-02	1.54e-01
Regulation of TP53 Activity through Methylation	19	1.27e-01	2.12e-01	0.29100	-1.16e-01	-2.67e-01	3.83e-01	4.36e-02
Diseases associated with the TLR signaling cascade	29	4.14e-02	9.01e-02	0.29100	2.70e-01	1.09e-01	1.19e-02	3.08e-01
Diseases of Immune System	29	4.14e-02	9.01e-02	0.29100	2.70e-01	1.09e-01	1.19e-02	3.08e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	12	2.05e-01	3.06e-01	0.29100	-2.89e-01	-3.01e-02	8.28e-02	8.57e-01
Pre-NOTCH Processing in Golgi	18	1.16e-01	1.99e-01	0.29100	7.11e-02	2.82e-01	6.01e-01	3.85e-02
COPI-dependent Golgi-to-ER retrograde traffic	90	6.20e-08	5.47e-07	0.29100	-1.73e-01	2.33e-01	4.48e-03	1.31e-04
Transport of RCbl within the body	8	3.29e-01	4.32e-01	0.29000	-2.90e-01	-6.97e-03	1.55e-01	9.73e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.09e-02	3.09e-02	0.29000	-2.89e-01	3.09e-02	6.20e-03	7.70e-01
CS/DS degradation	9	3.82e-01	4.83e-01	0.29000	-1.17e-01	-2.65e-01	5.42e-01	1.69e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	2.12e-01	3.15e-01	0.29000	6.99e-02	2.81e-01	6.62e-01	7.93e-02
Viral Infection Pathways	769	7.13e-39	3.91e-37	0.29000	-2.80e-01	-7.37e-02	6.04e-40	5.10e-04
RIP-mediated NFkB activation via ZBP1	17	1.94e-01	2.92e-01	0.28900	2.30e-01	1.76e-01	1.01e-01	2.08e-01
E2F-enabled inhibition of pre-replication complex formation	9	2.42e-01	3.47e-01	0.28900	-2.84e-01	5.67e-02	1.40e-01	7.68e-01
Signalling to RAS	19	1.01e-01	1.78e-01	0.28900	6.34e-02	2.82e-01	6.32e-01	3.32e-02
Neurotransmitter clearance	6	5.65e-01	6.53e-01	0.28900	-2.17e-01	-1.91e-01	3.57e-01	4.19e-01
Gain-of-function MRAS complexes activate RAF signaling	8	4.07e-01	5.06e-01	0.28900	9.30e-02	2.74e-01	6.49e-01	1.80e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	4.07e-01	5.06e-01	0.28900	9.30e-02	2.74e-01	6.49e-01	1.80e-01
Signaling by MRAS-complex mutants	8	4.07e-01	5.06e-01	0.28900	9.30e-02	2.74e-01	6.49e-01	1.80e-01
Diseases associated with O-glycosylation of proteins	46	8.50e-03	2.48e-02	0.28900	2.59e-01	1.27e-01	2.36e-03	1.35e-01
PD-1 signaling	28	1.07e-02	3.06e-02	0.28800	7.60e-02	-2.78e-01	4.87e-01	1.08e-02
HDR through Homologous Recombination (HRR)	68	1.27e-03	4.92e-03	0.28800	-2.43e-01	-1.55e-01	5.32e-04	2.68e-02
SUMOylation of ubiquitinylation proteins	39	1.68e-02	4.32e-02	0.28800	-1.20e-01	-2.62e-01	1.96e-01	4.65e-03
RAS processing	23	4.78e-02	1.01e-01	0.28800	-2.87e-01	-2.08e-02	1.71e-02	8.63e-01
Toxicity of botulinum toxin type D (botD)	5	4.05e-01	5.05e-01	0.28800	1.68e-01	-2.34e-01	5.16e-01	3.66e-01
Toxicity of botulinum toxin type F (botF)	5	4.05e-01	5.05e-01	0.28800	1.68e-01	-2.34e-01	5.16e-01	3.66e-01
Amine ligand-binding receptors	10	3.35e-01	4.37e-01	0.28700	2.70e-01	9.98e-02	1.40e-01	5.85e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	9	2.16e-01	3.19e-01	0.28700	-1.12e-01	2.65e-01	5.60e-01	1.69e-01
Defective EXT2 causes exostoses 2	9	2.16e-01	3.19e-01	0.28700	-1.12e-01	2.65e-01	5.60e-01	1.69e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	7.06e-02	1.35e-01	0.28700	2.24e-01	1.80e-01	3.99e-02	9.98e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	2.51e-03	8.91e-03	0.28700	1.00e-01	2.69e-01	1.98e-01	5.48e-04
Phosphorylation of CD3 and TCR zeta chains	27	1.30e-02	3.53e-02	0.28700	7.58e-02	-2.77e-01	4.96e-01	1.27e-02
Signaling by ERBB2 in Cancer	21	1.40e-01	2.29e-01	0.28700	2.00e-01	2.07e-01	1.13e-01	1.01e-01
Detoxification of Reactive Oxygen Species	30	4.56e-03	1.47e-02	0.28700	-2.35e-01	1.65e-01	2.62e-02	1.17e-01
Regulation of insulin secretion	62	1.79e-03	6.61e-03	0.28700	1.28e-01	2.57e-01	8.20e-02	4.69e-04
Signaling by PDGFR in disease	19	1.53e-01	2.44e-01	0.28700	1.45e-01	2.47e-01	2.74e-01	6.22e-02
Attenuation phase	22	4.11e-02	9.00e-02	0.28600	-2.57e-02	2.85e-01	8.34e-01	2.06e-02
Coenzyme A biosynthesis	7	5.21e-01	6.12e-01	0.28600	-2.16e-01	-1.88e-01	3.22e-01	3.90e-01
Neurofascin interactions	5	5.67e-01	6.54e-01	0.28600	7.93e-02	2.75e-01	7.59e-01	2.87e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	1.69e-01	2.62e-01	0.28600	-4.81e-04	2.86e-01	9.98e-01	7.43e-02
HCMV Late Events	67	2.28e-04	1.08e-03	0.28600	-2.83e-01	-3.66e-02	6.00e-05	6.05e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	5.17e-03	1.63e-02	0.28600	1.95e-01	2.08e-01	1.07e-02	6.51e-03
Synaptic adhesion-like molecules	14	1.65e-01	2.58e-01	0.28600	2.84e-01	2.46e-02	6.53e-02	8.73e-01
RHO GTPases activate CIT	18	4.32e-02	9.29e-02	0.28500	-1.44e-01	2.46e-01	2.91e-01	7.02e-02
Interactions of Rev with host cellular proteins	37	2.34e-02	5.71e-02	0.28500	-1.25e-01	-2.57e-01	1.88e-01	6.93e-03
Transport of Ribonucleoproteins into the Host Nucleus	32	1.40e-02	3.76e-02	0.28500	-8.79e-03	-2.85e-01	9.31e-01	5.25e-03
Nuclear Envelope (NE) Reassembly	68	5.11e-05	2.79e-04	0.28400	-2.82e-01	3.50e-02	5.83e-05	6.17e-01
Negative feedback regulation of MAPK pathway	6	3.76e-01	4.78e-01	0.28400	-2.66e-01	9.84e-02	2.59e-01	6.77e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	9	2.71e-01	3.78e-01	0.28300	2.81e-01	-3.49e-02	1.44e-01	8.56e-01
Caspase activation via Death Receptors in the presence of ligand	16	8.31e-02	1.53e-01	0.28300	2.74e-01	-7.23e-02	5.80e-02	6.17e-01
CLEC7A (Dectin-1) induces NFAT activation	11	3.21e-01	4.24e-01	0.28300	2.61e-01	1.08e-01	1.34e-01	5.33e-01
RHO GTPases Activate ROCKs	18	8.24e-02	1.52e-01	0.28300	-1.60e-02	2.82e-01	9.06e-01	3.81e-02
Antigen processing-Cross presentation	88	4.11e-06	2.73e-05	0.28300	-2.82e-01	2.52e-02	4.97e-06	6.83e-01
Acyl chain remodelling of PG	11	2.78e-01	3.86e-01	0.28300	5.77e-02	2.77e-01	7.40e-01	1.12e-01
Signal regulatory protein family interactions	13	1.16e-01	1.98e-01	0.28200	-1.17e-01	2.57e-01	4.65e-01	1.08e-01
Autophagy	142	1.09e-07	9.10e-07	0.28200	-2.74e-01	-6.71e-02	1.67e-08	1.67e-01
Assembly Of The HIV Virion	15	1.81e-01	2.77e-01	0.28200	-2.74e-01	-6.54e-02	6.57e-02	6.61e-01
Infection with Mycobacterium tuberculosis	26	1.90e-02	4.81e-02	0.28200	-2.74e-01	6.56e-02	1.55e-02	5.63e-01
DNA Repair	288	2.68e-12	3.84e-11	0.28200	-2.36e-01	-1.53e-01	5.16e-12	7.54e-06
Platelet activation, signaling and aggregation	219	2.74e-17	6.59e-16	0.28200	-1.99e-01	1.99e-01	3.70e-07	3.88e-07
FGFR1b ligand binding and activation	5	4.98e-01	5.90e-01	0.28100	2.30e-02	-2.81e-01	9.29e-01	2.77e-01
Peptide ligand-binding receptors	98	5.94e-06	3.83e-05	0.28100	3.05e-02	2.80e-01	6.01e-01	1.71e-06
G beta:gamma signalling through BTK	15	7.81e-02	1.46e-01	0.28100	-1.44e-01	2.42e-01	3.35e-01	1.05e-01
Leishmania infection	209	2.33e-16	5.26e-15	0.28100	-1.77e-01	2.18e-01	1.09e-05	5.26e-08
Parasitic Infection Pathways	209	2.33e-16	5.26e-15	0.28100	-1.77e-01	2.18e-01	1.09e-05	5.26e-08
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	1.86e-01	2.82e-01	0.28100	-2.71e-01	7.14e-02	1.19e-01	6.82e-01
Protein folding	83	2.81e-06	1.92e-05	0.28000	-2.69e-01	7.83e-02	2.21e-05	2.17e-01
RHOT2 GTPase cycle	7	2.98e-01	4.07e-01	0.28000	-2.08e-01	1.87e-01	3.40e-01	3.92e-01
Signaling by EGFR in Cancer	22	1.16e-01	1.99e-01	0.27900	1.19e-01	2.52e-01	3.35e-01	4.04e-02
mTORC1-mediated signalling	24	5.41e-02	1.09e-01	0.27900	-2.77e-01	-2.88e-02	1.86e-02	8.07e-01
Activation of ATR in response to replication stress	37	3.11e-02	7.26e-02	0.27900	-2.42e-01	-1.37e-01	1.07e-02	1.49e-01
Signaling by PDGF	48	7.00e-03	2.11e-02	0.27800	9.23e-02	2.63e-01	2.69e-01	1.64e-03
Defects in vitamin and cofactor metabolism	21	1.40e-01	2.29e-01	0.27800	-1.36e-01	-2.42e-01	2.79e-01	5.45e-02
Factors involved in megakaryocyte development and platelet production	128	1.38e-07	1.14e-06	0.27700	1.63e-02	2.77e-01	7.50e-01	6.18e-08
Interleukin-1 processing	8	3.41e-01	4.42e-01	0.27700	2.77e-01	-1.95e-02	1.75e-01	9.24e-01
Regulated proteolysis of p75NTR	11	1.55e-01	2.45e-01	0.27700	-1.86e-01	2.05e-01	2.85e-01	2.39e-01
p38MAPK events	13	2.07e-01	3.09e-01	0.27700	2.38e-02	2.76e-01	8.82e-01	8.51e-02
MAPK6/MAPK4 signaling	69	1.43e-05	8.71e-05	0.27700	-2.46e-01	1.27e-01	4.15e-04	6.74e-02
Suppression of apoptosis	7	3.12e-01	4.20e-01	0.27600	-1.57e-01	2.27e-01	4.72e-01	2.97e-01
Transport of the SLBP Dependant Mature mRNA	36	2.96e-02	6.95e-02	0.27600	-1.09e-01	-2.54e-01	2.59e-01	8.35e-03
Triglyceride metabolism	24	1.18e-01	2.00e-01	0.27500	1.51e-01	2.30e-01	2.00e-01	5.10e-02
Ca2+ pathway	57	6.20e-03	1.90e-02	0.27500	1.50e-01	2.31e-01	5.06e-02	2.57e-03
Protein ubiquitination	71	4.89e-05	2.69e-04	0.27500	-2.71e-01	4.71e-02	7.98e-05	4.93e-01
Activated NTRK2 signals through RAS	6	5.64e-01	6.52e-01	0.27500	1.14e-01	2.50e-01	6.29e-01	2.89e-01
Activated NTRK3 signals through RAS	6	5.64e-01	6.52e-01	0.27500	1.14e-01	2.50e-01	6.29e-01	2.89e-01
Thromboxane signalling through TP receptor	20	3.88e-02	8.58e-02	0.27500	-1.43e-01	2.34e-01	2.67e-01	6.97e-02
SUMO is proteolytically processed	6	5.98e-01	6.81e-01	0.27500	-2.00e-01	-1.88e-01	3.95e-01	4.26e-01
Transcriptional regulation by RUNX2	87	3.52e-06	2.38e-05	0.27400	-2.66e-01	6.54e-02	1.74e-05	2.92e-01
Degradation of the extracellular matrix	92	1.58e-04	7.74e-04	0.27400	1.13e-01	2.50e-01	6.20e-02	3.38e-05
RHOU GTPase cycle	40	3.12e-02	7.27e-02	0.27400	2.20e-01	1.63e-01	1.60e-02	7.43e-02
Potassium Channels	61	4.62e-03	1.49e-02	0.27400	1.50e-01	2.29e-01	4.33e-02	1.96e-03
NR1H2 and NR1H3-mediated signaling	38	3.75e-02	8.39e-02	0.27400	2.19e-01	1.64e-01	1.95e-02	7.99e-02
Activation of PUMA and translocation to mitochondria	8	3.50e-01	4.52e-01	0.27400	2.73e-01	-1.99e-02	1.81e-01	9.22e-01
RHOBTB GTPase Cycle	35	3.62e-03	1.21e-02	0.27400	-2.35e-01	1.40e-01	1.61e-02	1.52e-01
Cellular responses to stress	694	3.13e-35	1.50e-33	0.27300	-2.72e-01	-2.48e-02	1.85e-34	2.67e-01
Class B/2 (Secretin family receptors)	52	1.17e-02	3.26e-02	0.27300	2.14e-01	1.70e-01	7.66e-03	3.34e-02
Cardiac conduction	86	5.24e-04	2.29e-03	0.27300	1.49e-01	2.29e-01	1.66e-02	2.42e-04
Rev-mediated nuclear export of HIV RNA	35	3.90e-02	8.61e-02	0.27300	-1.21e-01	-2.45e-01	2.14e-01	1.22e-02
Thyroxine biosynthesis	5	4.56e-01	5.52e-01	0.27200	2.41e-01	-1.28e-01	3.52e-01	6.21e-01
Negative regulation of MET activity	18	1.70e-01	2.63e-01	0.27200	9.19e-02	2.56e-01	5.00e-01	5.99e-02
Cargo concentration in the ER	31	2.37e-02	5.76e-02	0.27200	1.03e-02	2.72e-01	9.21e-01	8.80e-03
Diseases of DNA repair	50	1.52e-02	4.02e-02	0.27200	-1.91e-01	-1.94e-01	1.95e-02	1.78e-02
AMPK inhibits chREBP transcriptional activation activity	6	5.94e-01	6.78e-01	0.27100	-1.48e-01	-2.27e-01	5.31e-01	3.35e-01
TGFBR3 regulates TGF-beta signaling	8	2.82e-01	3.89e-01	0.27000	1.46e-01	-2.28e-01	4.75e-01	2.65e-01
Glycine degradation	7	3.22e-01	4.25e-01	0.27000	-1.87e-01	1.95e-01	3.91e-01	3.71e-01
APC truncation mutants have impaired AXIN binding	14	3.14e-01	4.20e-01	0.27000	2.01e-01	1.80e-01	1.92e-01	2.45e-01
AXIN missense mutants destabilize the destruction complex	14	3.14e-01	4.20e-01	0.27000	2.01e-01	1.80e-01	1.92e-01	2.45e-01
Signaling by AMER1 mutants	14	3.14e-01	4.20e-01	0.27000	2.01e-01	1.80e-01	1.92e-01	2.45e-01
Signaling by APC mutants	14	3.14e-01	4.20e-01	0.27000	2.01e-01	1.80e-01	1.92e-01	2.45e-01
Signaling by AXIN mutants	14	3.14e-01	4.20e-01	0.27000	2.01e-01	1.80e-01	1.92e-01	2.45e-01
Truncations of AMER1 destabilize the destruction complex	14	3.14e-01	4.20e-01	0.27000	2.01e-01	1.80e-01	1.92e-01	2.45e-01
TNFR1-induced proapoptotic signaling	24	1.01e-01	1.78e-01	0.26900	2.52e-01	9.53e-02	3.26e-02	4.19e-01
DARPP-32 events	22	4.20e-02	9.11e-02	0.26900	-8.26e-02	2.56e-01	5.03e-01	3.75e-02
ADP signalling through P2Y purinoceptor 12	18	6.07e-02	1.20e-01	0.26900	-1.38e-01	2.31e-01	3.12e-01	8.93e-02
Metabolism of proteins	1758	1.31e-70	6.27e-68	0.26900	-2.57e-01	-7.94e-02	5.97e-72	3.34e-08
Defective Intrinsic Pathway for Apoptosis	24	5.59e-02	1.12e-01	0.26900	-2.69e-01	-2.76e-03	2.26e-02	9.81e-01
Insulin processing	18	2.30e-01	3.33e-01	0.26800	1.97e-01	1.82e-01	1.48e-01	1.81e-01
Nuclear import of Rev protein	34	3.85e-02	8.52e-02	0.26800	-8.93e-02	-2.53e-01	3.68e-01	1.07e-02
Acyl chain remodelling of PC	19	1.75e-01	2.69e-01	0.26800	1.05e-01	2.46e-01	4.27e-01	6.34e-02
Hemostasis	552	3.26e-37	1.74e-35	0.26700	-1.54e-01	2.18e-01	6.44e-10	1.73e-18
SUMOylation of RNA binding proteins	47	2.07e-02	5.15e-02	0.26700	-1.56e-01	-2.16e-01	6.35e-02	1.04e-02
Synthesis, secretion, and deacylation of Ghrelin	11	4.05e-01	5.05e-01	0.26700	-1.59e-01	-2.14e-01	3.62e-01	2.18e-01
Signaling by RAF1 mutants	36	3.57e-03	1.19e-02	0.26700	-2.05e-01	1.71e-01	3.35e-02	7.62e-02
Processing of DNA double-strand break ends	69	2.34e-04	1.11e-03	0.26600	-2.66e-01	9.13e-03	1.30e-04	8.96e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	4.86e-01	5.82e-01	0.26600	-9.39e-02	2.49e-01	7.16e-01	3.34e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	4.86e-01	5.82e-01	0.26600	-9.39e-02	2.49e-01	7.16e-01	3.34e-01
Activation of G protein gated Potassium channels	18	1.62e-01	2.55e-01	0.26600	6.29e-02	2.59e-01	6.44e-01	5.72e-02
G protein gated Potassium channels	18	1.62e-01	2.55e-01	0.26600	6.29e-02	2.59e-01	6.44e-01	5.72e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	1.62e-01	2.55e-01	0.26600	6.29e-02	2.59e-01	6.44e-01	5.72e-02
Other interleukin signaling	18	1.85e-01	2.81e-01	0.26600	2.50e-01	9.27e-02	6.67e-02	4.96e-01
RHOF GTPase cycle	38	2.66e-02	6.36e-02	0.26600	8.48e-02	2.52e-01	3.66e-01	7.07e-03
Sema3A PAK dependent Axon repulsion	15	2.44e-01	3.48e-01	0.26600	9.01e-02	2.50e-01	5.46e-01	9.33e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	1.01e-05	6.29e-05	0.26600	-2.65e-01	-2.53e-02	3.08e-06	6.55e-01
CTNNB1 S33 mutants aren’t phosphorylated	15	3.02e-01	4.10e-01	0.26500	1.92e-01	1.84e-01	1.99e-01	2.18e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	3.02e-01	4.10e-01	0.26500	1.92e-01	1.84e-01	1.99e-01	2.18e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	3.02e-01	4.10e-01	0.26500	1.92e-01	1.84e-01	1.99e-01	2.18e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	3.02e-01	4.10e-01	0.26500	1.92e-01	1.84e-01	1.99e-01	2.18e-01
Signaling by CTNNB1 phospho-site mutants	15	3.02e-01	4.10e-01	0.26500	1.92e-01	1.84e-01	1.99e-01	2.18e-01
Signaling by GSK3beta mutants	15	3.02e-01	4.10e-01	0.26500	1.92e-01	1.84e-01	1.99e-01	2.18e-01
TRAF3-dependent IRF activation pathway	13	2.45e-01	3.49e-01	0.26500	2.63e-01	3.42e-02	1.00e-01	8.31e-01
Suppression of phagosomal maturation	12	3.09e-01	4.17e-01	0.26500	-2.55e-01	-7.21e-02	1.26e-01	6.65e-01
LGI-ADAM interactions	9	3.20e-01	4.24e-01	0.26500	2.63e-01	-3.11e-02	1.71e-01	8.72e-01
PI Metabolism	79	1.03e-03	4.15e-03	0.26500	2.38e-01	1.16e-01	2.56e-04	7.54e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	4.25e-02	9.16e-02	0.26400	2.25e-01	1.39e-01	1.64e-02	1.38e-01
Metabolism of nitric oxide: NOS3 activation and regulation	13	3.10e-01	4.18e-01	0.26400	-2.44e-01	-1.02e-01	1.28e-01	5.24e-01
RHOB GTPase cycle	64	1.60e-03	5.99e-03	0.26400	5.71e-02	2.58e-01	4.29e-01	3.60e-04
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	1.21e-03	4.72e-03	0.26400	-6.45e-02	2.56e-01	4.30e-01	1.73e-03
Transcriptional regulation of pluripotent stem cells	18	2.33e-01	3.36e-01	0.26400	2.14e-01	1.54e-01	1.15e-01	2.58e-01
Homology Directed Repair	110	1.21e-05	7.45e-05	0.26400	-2.60e-01	-4.61e-02	2.56e-06	4.03e-01
G-protein activation	19	6.25e-02	1.22e-01	0.26300	-1.18e-01	2.35e-01	3.73e-01	7.58e-02
CASP8 activity is inhibited	11	2.21e-01	3.24e-01	0.26300	2.51e-01	-7.83e-02	1.49e-01	6.53e-01
Dimerization of procaspase-8	11	2.21e-01	3.24e-01	0.26300	2.51e-01	-7.83e-02	1.49e-01	6.53e-01
Regulation by c-FLIP	11	2.21e-01	3.24e-01	0.26300	2.51e-01	-7.83e-02	1.49e-01	6.53e-01
Role of second messengers in netrin-1 signaling	6	5.87e-01	6.71e-01	0.26300	2.42e-01	1.01e-01	3.04e-01	6.67e-01
Diseases of carbohydrate metabolism	29	8.49e-02	1.56e-01	0.26200	-2.34e-01	-1.18e-01	2.92e-02	2.70e-01
Semaphorin interactions	56	1.39e-03	5.29e-03	0.26200	-1.09e-02	2.62e-01	8.88e-01	7.11e-04
PECAM1 interactions	12	3.94e-01	4.94e-01	0.26200	1.90e-01	1.80e-01	2.56e-01	2.80e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	32	3.85e-02	8.52e-02	0.26100	4.44e-02	2.57e-01	6.64e-01	1.17e-02
Glyoxylate metabolism and glycine degradation	13	2.59e-01	3.64e-01	0.26100	-2.58e-01	-3.60e-02	1.07e-01	8.22e-01
TP53 Regulates Transcription of DNA Repair Genes	61	8.58e-03	2.50e-02	0.26100	-2.06e-01	-1.61e-01	5.49e-03	3.01e-02
Chaperonin-mediated protein folding	77	2.08e-05	1.24e-04	0.26100	-2.39e-01	1.04e-01	2.87e-04	1.16e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	4.98e-02	1.04e-01	0.26000	-7.25e-02	-2.50e-01	4.78e-01	1.44e-02
Collagen chain trimerization	26	1.35e-01	2.22e-01	0.26000	1.97e-01	1.70e-01	8.18e-02	1.34e-01
WNT5A-dependent internalization of FZD4	13	1.55e-01	2.45e-01	0.26000	-2.30e-01	1.22e-01	1.51e-01	4.48e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	2.34e-02	5.71e-02	0.26000	3.02e-02	2.58e-01	7.54e-01	7.40e-03
Synthesis of PIPs at the Golgi membrane	16	9.82e-02	1.74e-01	0.25900	2.20e-01	-1.37e-01	1.27e-01	3.43e-01
trans-Golgi Network Vesicle Budding	69	1.32e-04	6.52e-04	0.25800	-2.49e-01	6.73e-02	3.41e-04	3.34e-01
activated TAK1 mediates p38 MAPK activation	23	4.33e-02	9.29e-02	0.25800	-9.68e-02	2.39e-01	4.22e-01	4.69e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	4.94e-01	5.87e-01	0.25800	-2.22e-02	2.57e-01	9.25e-01	2.75e-01
Peroxisomal lipid metabolism	27	1.18e-01	2.00e-01	0.25800	-2.20e-01	-1.34e-01	4.77e-02	2.27e-01
Platelet homeostasis	69	3.86e-04	1.77e-03	0.25800	-1.09e-02	2.58e-01	8.76e-01	2.16e-04
HCMV Infection	106	2.00e-05	1.20e-04	0.25800	-2.56e-01	-3.12e-02	5.34e-06	5.79e-01
Activation of the AP-1 family of transcription factors	10	3.64e-01	4.66e-01	0.25700	3.45e-02	2.55e-01	8.50e-01	1.63e-01
Gamma-carboxylation of protein precursors	6	5.76e-01	6.62e-01	0.25700	6.93e-02	2.47e-01	7.69e-01	2.94e-01
Synthesis of PE	12	3.95e-01	4.95e-01	0.25700	-1.43e-01	-2.13e-01	3.90e-01	2.01e-01
Metabolism of steroid hormones	21	9.04e-02	1.63e-01	0.25600	-2.56e-01	1.61e-02	4.23e-02	8.98e-01
Activation of Ca-permeable Kainate Receptor	8	5.32e-01	6.23e-01	0.25600	2.21e-01	1.30e-01	2.79e-01	5.24e-01
Ionotropic activity of kainate receptors	8	5.32e-01	6.23e-01	0.25600	2.21e-01	1.30e-01	2.79e-01	5.24e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	3.74e-01	4.78e-01	0.25600	1.57e-01	2.02e-01	3.26e-01	2.07e-01
Transport of the SLBP independent Mature mRNA	35	4.66e-02	9.87e-02	0.25600	-8.51e-02	-2.42e-01	3.84e-01	1.33e-02
Bile acid and bile salt metabolism	28	8.47e-02	1.55e-01	0.25600	2.43e-01	8.07e-02	2.63e-02	4.60e-01
Reversible hydration of carbon dioxide	8	5.52e-01	6.41e-01	0.25600	1.68e-01	1.92e-01	4.10e-01	3.46e-01
Nuclear events stimulated by ALK signaling in cancer	33	8.74e-02	1.58e-01	0.25500	1.89e-01	1.71e-01	6.03e-02	8.84e-02
Amino acids regulate mTORC1	48	3.85e-03	1.28e-02	0.25500	-2.53e-01	2.69e-02	2.38e-03	7.47e-01
SUMOylation of SUMOylation proteins	35	5.20e-02	1.07e-01	0.25400	-9.24e-02	-2.37e-01	3.44e-01	1.53e-02
TGFBR3 PTM regulation	10	3.04e-01	4.12e-01	0.25400	-2.50e-01	4.19e-02	1.70e-01	8.18e-01
RET signaling	32	7.76e-02	1.45e-01	0.25400	1.12e-01	2.27e-01	2.71e-01	2.61e-02
Association of TriC/CCT with target proteins during biosynthesis	35	3.30e-02	7.60e-02	0.25400	-2.51e-01	-3.70e-02	1.02e-02	7.05e-01
Cellular response to chemical stress	178	1.73e-11	2.29e-10	0.25300	-2.05e-01	1.48e-01	2.34e-06	6.36e-04
Activation of AMPK downstream of NMDARs	20	6.34e-02	1.23e-01	0.25300	-1.31e-01	2.16e-01	3.09e-01	9.37e-02
IL-6-type cytokine receptor ligand interactions	12	3.29e-01	4.32e-01	0.25300	2.47e-01	5.50e-02	1.38e-01	7.41e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	3.77e-01	4.79e-01	0.25300	-2.50e-01	-3.58e-02	1.70e-01	8.45e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	4.75e-02	1.00e-01	0.25300	-2.53e-01	-6.96e-03	1.84e-02	9.48e-01
Cell-extracellular matrix interactions	15	1.20e-01	2.04e-01	0.25300	-1.94e-01	1.62e-01	1.94e-01	2.76e-01
Cellular responses to stimuli	775	5.85e-36	2.88e-34	0.25300	-2.53e-01	4.74e-03	4.57e-33	8.23e-01
RMTs methylate histone arginines	35	4.12e-02	9.00e-02	0.25200	-2.45e-01	-5.64e-02	1.20e-02	5.63e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	2.59e-01	3.64e-01	0.25200	-2.45e-02	2.51e-01	8.83e-01	1.33e-01
alpha-linolenic acid (ALA) metabolism	12	2.59e-01	3.64e-01	0.25200	-2.45e-02	2.51e-01	8.83e-01	1.33e-01
Metalloprotease DUBs	20	6.06e-02	1.20e-01	0.25200	-1.74e-01	1.82e-01	1.79e-01	1.58e-01
Negative regulation of FGFR3 signaling	21	7.25e-02	1.38e-01	0.25200	-2.41e-01	7.34e-02	5.63e-02	5.60e-01
Integration of energy metabolism	87	6.75e-04	2.85e-03	0.25100	8.23e-02	2.37e-01	1.85e-01	1.33e-04
O-linked glycosylation	81	3.16e-03	1.08e-02	0.25100	1.72e-01	1.83e-01	7.62e-03	4.45e-03
Mitotic G2-G2/M phases	179	4.13e-10	4.67e-09	0.25100	-2.43e-01	6.26e-02	2.12e-08	1.48e-01
Translation of Structural Proteins 9694635	55	6.13e-04	2.61e-03	0.25100	-2.16e-01	1.27e-01	5.60e-03	1.03e-01
Calnexin/calreticulin cycle	26	4.25e-02	9.16e-02	0.25100	-2.43e-01	6.29e-02	3.23e-02	5.79e-01
Nucleotide salvage	21	8.07e-02	1.49e-01	0.25000	-2.44e-01	5.67e-02	5.29e-02	6.53e-01
Late SARS-CoV-2 Infection Events	63	1.70e-04	8.20e-04	0.25000	-1.87e-01	1.66e-01	1.02e-02	2.29e-02
Beta-catenin phosphorylation cascade	17	2.59e-01	3.64e-01	0.25000	1.01e-01	2.29e-01	4.72e-01	1.03e-01
Prostacyclin signalling through prostacyclin receptor	16	1.17e-01	2.00e-01	0.25000	-2.14e-01	1.28e-01	1.38e-01	3.74e-01
Nephron development	5	6.66e-01	7.36e-01	0.25000	9.13e-02	2.32e-01	7.24e-01	3.69e-01
Sphingolipid de novo biosynthesis	34	1.35e-02	3.65e-02	0.24900	-2.32e-01	9.05e-02	1.90e-02	3.61e-01
CLEC7A/inflammasome pathway	6	6.42e-01	7.18e-01	0.24900	2.12e-01	1.31e-01	3.69e-01	5.78e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	1.67e-01	2.59e-01	0.24900	-2.42e-01	5.92e-02	1.05e-01	6.91e-01
Circadian Clock	67	8.51e-03	2.49e-02	0.24900	1.51e-01	1.98e-01	3.24e-02	5.15e-03
Netrin-1 signaling	34	4.92e-02	1.03e-01	0.24800	5.58e-02	2.42e-01	5.73e-01	1.46e-02
Processing of Intronless Pre-mRNAs	20	2.46e-01	3.50e-01	0.24800	-1.61e-01	-1.88e-01	2.11e-01	1.45e-01
GPVI-mediated activation cascade	31	9.74e-02	1.73e-01	0.24700	1.14e-01	2.19e-01	2.70e-01	3.47e-02
G2/M Transition	177	9.01e-10	9.78e-09	0.24700	-2.39e-01	6.33e-02	4.19e-08	1.47e-01
Unfolded Protein Response (UPR)	84	1.23e-04	6.17e-04	0.24700	-2.46e-01	2.00e-02	9.54e-05	7.51e-01
Ca-dependent events	29	1.35e-01	2.22e-01	0.24700	1.68e-01	1.81e-01	1.17e-01	9.23e-02
Phase 2 - plateau phase	11	4.54e-01	5.50e-01	0.24700	2.07e-01	1.35e-01	2.35e-01	4.40e-01
Intrinsic Pathway for Apoptosis	53	1.62e-02	4.19e-02	0.24700	-2.26e-01	-9.79e-02	4.34e-03	2.18e-01
Phase II - Conjugation of compounds	68	1.04e-03	4.18e-03	0.24700	-2.47e-01	-2.19e-03	4.34e-04	9.75e-01
G2/M DNA damage checkpoint	66	4.94e-04	2.20e-03	0.24700	-2.41e-01	5.30e-02	7.12e-04	4.57e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	40	5.90e-03	1.82e-02	0.24600	-2.19e-01	1.14e-01	1.68e-02	2.13e-01
Signaling by RAS mutants	40	5.90e-03	1.82e-02	0.24600	-2.19e-01	1.14e-01	1.68e-02	2.13e-01
Signaling by moderate kinase activity BRAF mutants	40	5.90e-03	1.82e-02	0.24600	-2.19e-01	1.14e-01	1.68e-02	2.13e-01
Signaling downstream of RAS mutants	40	5.90e-03	1.82e-02	0.24600	-2.19e-01	1.14e-01	1.68e-02	2.13e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	4.65e-02	9.86e-02	0.24600	-1.33e-01	-2.07e-01	1.31e-01	1.90e-02
MHC class II antigen presentation	113	6.22e-07	4.58e-06	0.24600	-2.20e-01	1.10e-01	5.54e-05	4.33e-02
COPI-mediated anterograde transport	92	5.02e-06	3.28e-05	0.24500	-1.68e-01	1.79e-01	5.40e-03	3.03e-03
G-protein mediated events	43	5.30e-02	1.08e-01	0.24500	1.85e-01	1.60e-01	3.54e-02	6.91e-02
Organic anion transporters	7	5.81e-01	6.66e-01	0.24500	-9.26e-02	-2.26e-01	6.71e-01	3.00e-01
Ca2+ activated K+ channels	6	5.57e-01	6.47e-01	0.24500	-2.44e-01	-1.01e-02	3.00e-01	9.66e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	6.21e-01	7.01e-01	0.24400	-1.76e-02	-2.44e-01	9.46e-01	3.45e-01
RNA Polymerase II Pre-transcription Events	77	1.44e-03	5.45e-03	0.24400	-2.37e-01	-5.67e-02	3.15e-04	3.90e-01
RHO GTPase Effectors	257	2.87e-15	5.87e-14	0.24400	-1.65e-01	1.79e-01	4.97e-06	7.45e-07
ROS and RNS production in phagocytes	30	2.71e-02	6.45e-02	0.24400	-8.45e-02	2.29e-01	4.23e-01	3.01e-02
Export of Viral Ribonucleoproteins from Nucleus	33	5.41e-02	1.09e-01	0.24400	-4.22e-02	-2.40e-01	6.75e-01	1.70e-02
Homologous DNA Pairing and Strand Exchange	43	5.52e-02	1.11e-01	0.24400	-1.82e-01	-1.62e-01	3.91e-02	6.58e-02
Neddylation	215	3.98e-08	3.61e-07	0.24400	-2.31e-01	-7.74e-02	5.31e-09	5.05e-02
MAPK1 (ERK2) activation	8	5.50e-01	6.40e-01	0.24400	1.03e-01	2.21e-01	6.13e-01	2.80e-01
Transferrin endocytosis and recycling	26	4.32e-02	9.29e-02	0.24300	-8.95e-02	2.26e-01	4.30e-01	4.59e-02
Class A/1 (Rhodopsin-like receptors)	172	1.92e-06	1.34e-05	0.24300	8.96e-02	2.26e-01	4.27e-02	3.13e-07
Gastrulation	73	7.70e-05	4.00e-04	0.24300	-1.86e-01	1.56e-01	6.05e-03	2.09e-02
Neutrophil degranulation	456	1.48e-23	5.57e-22	0.24300	-7.57e-02	2.31e-01	5.64e-03	3.01e-17
MAPK3 (ERK1) activation	9	4.51e-01	5.48e-01	0.24300	3.87e-02	2.40e-01	8.41e-01	2.13e-01
RAC2 GTPase cycle	85	2.34e-03	8.37e-03	0.24200	1.17e-01	2.12e-01	6.23e-02	7.15e-04
Golgi Associated Vesicle Biogenesis	55	1.15e-03	4.51e-03	0.24200	-2.16e-01	1.09e-01	5.66e-03	1.61e-01
Molybdenum cofactor biosynthesis	6	6.56e-01	7.28e-01	0.24100	-1.21e-01	-2.09e-01	6.09e-01	3.75e-01
Pyruvate metabolism	44	2.86e-02	6.77e-02	0.24100	-2.32e-01	-6.57e-02	7.73e-03	4.51e-01
TNFR2 non-canonical NF-kB pathway	83	3.05e-04	1.43e-03	0.24100	-2.41e-01	2.73e-03	1.48e-04	9.66e-01
Acyl chain remodelling of PI	10	4.44e-01	5.42e-01	0.24000	6.12e-02	2.32e-01	7.37e-01	2.03e-01
IRS-related events triggered by IGF1R	36	8.55e-02	1.56e-01	0.24000	2.03e-01	1.28e-01	3.48e-02	1.85e-01
HSF1 activation	25	5.91e-02	1.17e-01	0.24000	-2.30e-01	6.73e-02	4.61e-02	5.60e-01
p75NTR signals via NF-kB	15	2.45e-01	3.49e-01	0.24000	-2.40e-01	-9.51e-03	1.08e-01	9.49e-01
GRB2 events in ERBB2 signaling	11	4.80e-01	5.76e-01	0.24000	1.40e-01	1.94e-01	4.21e-01	2.64e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	3.34e-03	1.14e-02	0.23900	1.26e-01	2.03e-01	4.56e-02	1.28e-03
Metabolism of porphyrins	22	9.47e-02	1.69e-01	0.23900	-2.35e-01	4.52e-02	5.65e-02	7.13e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	3.12e-02	7.28e-02	0.23900	-1.04e-01	2.15e-01	3.34e-01	4.49e-02
Infectious disease	950	6.49e-37	3.37e-35	0.23900	-2.38e-01	-1.56e-02	1.30e-35	4.15e-01
Formation of RNA Pol II elongation complex	56	1.12e-02	3.16e-02	0.23900	-2.31e-01	-6.05e-02	2.78e-03	4.34e-01
RNA Polymerase II Transcription Elongation	56	1.12e-02	3.16e-02	0.23900	-2.31e-01	-6.05e-02	2.78e-03	4.34e-01
PLC beta mediated events	39	7.90e-02	1.47e-01	0.23900	1.85e-01	1.51e-01	4.61e-02	1.02e-01
Rap1 signalling	14	3.08e-01	4.16e-01	0.23900	4.43e-02	2.35e-01	7.74e-01	1.29e-01
PIWI-interacting RNA (piRNA) biogenesis	23	2.18e-01	3.21e-01	0.23800	-1.37e-01	-1.95e-01	2.55e-01	1.05e-01
RHOJ GTPase cycle	49	6.38e-03	1.94e-02	0.23800	-3.30e-02	2.36e-01	6.90e-01	4.28e-03
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	2.29e-03	8.22e-03	0.23800	-2.04e-01	1.23e-01	1.26e-02	1.34e-01
EPHB-mediated forward signaling	38	1.08e-02	3.07e-02	0.23800	-1.07e-01	2.12e-01	2.53e-01	2.35e-02
Biosynthesis of maresins	5	7.26e-01	7.83e-01	0.23800	1.74e-01	1.62e-01	5.01e-01	5.30e-01
RAC1 GTPase cycle	170	1.87e-05	1.13e-04	0.23700	1.46e-01	1.86e-01	9.88e-04	2.79e-05
IGF1R signaling cascade	37	8.28e-02	1.53e-01	0.23700	2.04e-01	1.20e-01	3.17e-02	2.05e-01
VEGFA-VEGFR2 Pathway	92	9.50e-05	4.88e-04	0.23700	-2.86e-02	2.35e-01	6.36e-01	9.79e-05
Glycerophospholipid catabolism	6	4.75e-01	5.71e-01	0.23700	1.66e-01	-1.69e-01	4.81e-01	4.75e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	7.45e-02	1.41e-01	0.23700	-1.68e-01	-1.67e-01	6.32e-02	6.44e-02
Diseases of DNA Double-Strand Break Repair	41	7.45e-02	1.41e-01	0.23700	-1.68e-01	-1.67e-01	6.32e-02	6.44e-02
Signaling by KIT in disease	20	2.23e-01	3.26e-01	0.23600	2.24e-01	7.68e-02	8.33e-02	5.52e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	2.23e-01	3.26e-01	0.23600	2.24e-01	7.68e-02	8.33e-02	5.52e-01
RHOG GTPase cycle	70	8.30e-04	3.43e-03	0.23600	-3.22e-02	2.34e-01	6.41e-01	7.06e-04
RHOBTB3 ATPase cycle	10	3.19e-01	4.23e-01	0.23600	-2.17e-01	9.08e-02	2.34e-01	6.19e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	6.28e-01	7.08e-01	0.23600	6.22e-02	2.27e-01	7.92e-01	3.35e-01
Mitotic Spindle Checkpoint	107	1.13e-04	5.71e-04	0.23500	-2.33e-01	-2.87e-02	3.02e-05	6.08e-01
Unwinding of DNA	12	3.69e-01	4.72e-01	0.23500	-2.32e-01	-3.74e-02	1.64e-01	8.23e-01
Sialic acid metabolism	27	1.27e-01	2.12e-01	0.23500	6.49e-02	2.26e-01	5.60e-01	4.24e-02
Metabolism of fat-soluble vitamins	26	7.49e-02	1.41e-01	0.23500	-3.06e-02	2.33e-01	7.87e-01	4.01e-02
Vasopressin regulates renal water homeostasis via Aquaporins	34	6.57e-02	1.27e-01	0.23400	4.69e-02	2.29e-01	6.36e-01	2.06e-02
Nucleotide-like (purinergic) receptors	13	3.73e-01	4.76e-01	0.23400	6.48e-02	2.25e-01	6.86e-01	1.60e-01
Sphingolipid catabolism	11	2.73e-01	3.81e-01	0.23400	-1.22e-01	2.00e-01	4.85e-01	2.51e-01
Cell-cell junction organization	55	1.25e-02	3.43e-02	0.23400	2.29e-01	4.76e-02	3.30e-03	5.42e-01
Hyaluronan metabolism	15	1.65e-01	2.58e-01	0.23400	-1.42e-01	1.86e-01	3.42e-01	2.12e-01
DNA Double-Strand Break Repair	137	3.33e-05	1.92e-04	0.23400	-2.25e-01	-6.49e-02	5.68e-06	1.90e-01
Transport to the Golgi and subsequent modification	170	1.83e-09	1.92e-08	0.23300	-1.37e-01	1.89e-01	2.03e-03	2.15e-05
Activation of the TFAP2 (AP-2) family of transcription factors	7	4.37e-01	5.35e-01	0.23300	-1.95e-01	1.28e-01	3.71e-01	5.58e-01
Synthesis of bile acids and bile salts	25	1.22e-01	2.06e-01	0.23300	2.32e-01	2.71e-02	4.50e-02	8.14e-01
CREB phosphorylation	7	6.33e-01	7.12e-01	0.23300	2.02e-01	1.16e-01	3.56e-01	5.95e-01
Signaling by ALK fusions and activated point mutants	89	2.12e-03	7.64e-03	0.23300	9.11e-02	2.14e-01	1.37e-01	4.86e-04
Signaling by ALK in cancer	89	2.12e-03	7.64e-03	0.23300	9.11e-02	2.14e-01	1.37e-01	4.86e-04
Signaling by ERBB2 TMD/JMD mutants	17	3.53e-01	4.54e-01	0.23200	1.68e-01	1.60e-01	2.29e-01	2.53e-01
TRAF6 mediated IRF7 activation	15	3.42e-01	4.44e-01	0.23200	2.18e-01	8.03e-02	1.44e-01	5.90e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.18e-01	2.00e-01	0.23200	-2.32e-01	1.23e-02	5.46e-02	9.19e-01
GPCR ligand binding	235	3.40e-07	2.62e-06	0.23200	1.21e-01	1.98e-01	1.45e-03	1.76e-07
NCAM1 interactions	26	7.55e-02	1.42e-01	0.23100	2.27e-01	-4.12e-02	4.48e-02	7.16e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	2.04e-01	3.06e-01	0.23100	-2.27e-01	4.18e-02	1.16e-01	7.72e-01
Signaling by FGFR1 in disease	32	1.41e-01	2.30e-01	0.23000	1.39e-01	1.84e-01	1.74e-01	7.21e-02
Metabolism	1805	1.30e-53	1.79e-51	0.23000	-2.21e-01	-6.43e-02	7.60e-55	6.05e-06
Hedgehog ‘on’ state	64	1.12e-03	4.43e-03	0.23000	-2.16e-01	7.74e-02	2.77e-03	2.84e-01
HCMV Early Events	84	1.50e-03	5.63e-03	0.22900	-2.25e-01	-4.29e-02	3.55e-04	4.96e-01
Lysosphingolipid and LPA receptors	11	4.13e-01	5.12e-01	0.22900	2.27e-01	3.09e-02	1.92e-01	8.59e-01
Synthesis of PIPs at the early endosome membrane	16	2.40e-01	3.44e-01	0.22900	2.29e-01	-5.03e-03	1.12e-01	9.72e-01
Glycosphingolipid transport	7	6.51e-01	7.26e-01	0.22900	-1.30e-01	-1.89e-01	5.53e-01	3.87e-01
Constitutive Signaling by Overexpressed ERBB2	11	3.92e-01	4.92e-01	0.22900	1.00e-02	2.29e-01	9.54e-01	1.89e-01
Formation of annular gap junctions	10	3.17e-01	4.21e-01	0.22900	-1.41e-01	1.80e-01	4.39e-01	3.25e-01
Serotonin Neurotransmitter Release Cycle	15	4.10e-01	5.09e-01	0.22900	1.71e-01	1.52e-01	2.52e-01	3.09e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	4.05e-01	5.05e-01	0.22800	-2.15e-01	-7.59e-02	1.79e-01	6.36e-01
ADORA2B mediated anti-inflammatory cytokines production	35	4.60e-02	9.77e-02	0.22800	-3.54e-03	2.28e-01	9.71e-01	1.95e-02
Biosynthesis of specialized proresolving mediators (SPMs)	15	3.52e-01	4.53e-01	0.22800	7.47e-02	2.16e-01	6.17e-01	1.48e-01
Thrombin signalling through proteinase activated receptors (PARs)	27	5.12e-02	1.06e-01	0.22800	-1.07e-01	2.01e-01	3.35e-01	7.06e-02
Formation of the cornified envelope	32	5.99e-02	1.19e-01	0.22800	-5.54e-03	2.28e-01	9.57e-01	2.59e-02
Negative regulation of the PI3K/AKT network	91	3.98e-03	1.31e-02	0.22800	1.25e-01	1.90e-01	3.91e-02	1.73e-03
Muscle contraction	140	5.06e-05	2.78e-04	0.22700	6.56e-02	2.18e-01	1.80e-01	8.72e-06
M Phase	345	8.91e-15	1.71e-13	0.22700	-2.24e-01	3.65e-02	8.33e-13	2.44e-01
Neurexins and neuroligins	35	4.44e-02	9.50e-02	0.22700	2.27e-01	-1.15e-02	2.03e-02	9.07e-01
Pre-NOTCH Transcription and Translation	47	1.97e-02	4.94e-02	0.22700	9.83e-03	2.27e-01	9.07e-01	7.18e-03
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	6.54e-01	7.27e-01	0.22600	1.91e-01	1.21e-01	3.81e-01	5.78e-01
MET receptor recycling	9	5.81e-01	6.66e-01	0.22600	1.24e-01	1.89e-01	5.19e-01	3.26e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	7.55e-02	1.42e-01	0.22600	-1.14e-01	-1.95e-01	2.01e-01	2.84e-02
SARS-CoV-2 Infection	263	3.37e-08	3.08e-07	0.22600	-2.09e-01	-8.64e-02	5.24e-09	1.59e-02
TP53 Regulates Metabolic Genes	77	8.42e-04	3.47e-03	0.22600	-2.25e-01	2.73e-02	6.59e-04	6.79e-01
Acetylcholine regulates insulin secretion	9	5.73e-01	6.60e-01	0.22600	1.97e-01	1.11e-01	3.07e-01	5.65e-01
Negative regulators of DDX58/IFIH1 signaling	34	1.31e-01	2.17e-01	0.22500	-1.24e-01	-1.88e-01	2.11e-01	5.75e-02
P2Y receptors	10	5.61e-01	6.51e-01	0.22500	1.69e-01	1.49e-01	3.54e-01	4.15e-01
Meiosis	66	3.90e-03	1.29e-02	0.22500	-2.25e-01	-1.72e-03	1.58e-03	9.81e-01
RA biosynthesis pathway	13	3.67e-01	4.70e-01	0.22500	-3.02e-02	-2.23e-01	8.51e-01	1.65e-01
IRE1alpha activates chaperones	46	5.98e-03	1.84e-02	0.22400	-1.57e-01	1.60e-01	6.53e-02	6.01e-02
Downstream TCR signaling	89	1.04e-03	4.18e-03	0.22400	-2.23e-01	-2.77e-02	2.85e-04	6.51e-01
Erythropoietin activates STAT5	6	6.09e-01	6.91e-01	0.22400	5.33e-03	2.24e-01	9.82e-01	3.42e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	1.03e-01	1.82e-01	0.22400	-1.61e-01	-1.56e-01	7.86e-02	8.82e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	5.47e-02	1.10e-01	0.22400	-1.91e-01	1.17e-01	8.62e-02	2.94e-01
Transcriptional Regulation by E2F6	34	1.45e-01	2.34e-01	0.22400	-1.66e-01	-1.50e-01	9.48e-02	1.30e-01
CaM pathway	27	2.17e-01	3.20e-01	0.22300	1.72e-01	1.42e-01	1.22e-01	2.03e-01
Calmodulin induced events	27	2.17e-01	3.20e-01	0.22300	1.72e-01	1.42e-01	1.22e-01	2.03e-01
PI-3K cascade:FGFR1	13	4.61e-01	5.57e-01	0.22200	1.92e-01	1.12e-01	2.30e-01	4.85e-01
Surfactant metabolism	19	1.26e-01	2.12e-01	0.22200	-1.44e-01	1.69e-01	2.78e-01	2.01e-01
Aquaporin-mediated transport	38	6.59e-02	1.27e-01	0.22200	4.61e-02	2.17e-01	6.23e-01	2.05e-02
FRS-mediated FGFR3 signaling	12	4.21e-01	5.20e-01	0.22200	4.38e-02	2.18e-01	7.93e-01	1.92e-01
XBP1(S) activates chaperone genes	44	8.57e-03	2.50e-02	0.22200	-1.74e-01	1.38e-01	4.62e-02	1.13e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	2.04e-01	3.06e-01	0.22200	-1.15e-01	1.90e-01	4.40e-01	2.03e-01
ISG15 antiviral mechanism	72	1.78e-02	4.54e-02	0.22200	-1.44e-01	-1.69e-01	3.46e-02	1.33e-02
Molecules associated with elastic fibres	26	1.02e-01	1.80e-01	0.22100	-2.41e-02	2.20e-01	8.32e-01	5.21e-02
DAG and IP3 signaling	33	1.53e-01	2.44e-01	0.22100	1.80e-01	1.29e-01	7.38e-02	1.99e-01
FGFRL1 modulation of FGFR1 signaling	7	6.11e-01	6.92e-01	0.22100	2.16e-01	5.01e-02	3.23e-01	8.18e-01
Tryptophan catabolism	12	5.13e-01	6.07e-01	0.22100	-1.51e-01	-1.62e-01	3.66e-01	3.32e-01
Vesicle-mediated transport	662	5.25e-31	2.46e-29	0.22100	-1.51e-01	1.62e-01	3.49e-11	1.25e-12
DNA Double Strand Break Response	47	1.60e-02	4.16e-02	0.22100	-2.19e-01	2.67e-02	9.23e-03	7.51e-01
Activation of RAC1	11	4.88e-01	5.82e-01	0.22100	2.09e-01	7.28e-02	2.31e-01	6.76e-01
Regulation of NF-kappa B signaling	18	3.56e-01	4.57e-01	0.22000	-1.19e-01	-1.85e-01	3.80e-01	1.73e-01
Negative regulation of FGFR4 signaling	22	1.17e-01	2.00e-01	0.22000	-2.08e-01	7.21e-02	9.09e-02	5.58e-01
ER to Golgi Anterograde Transport	145	2.50e-07	1.94e-06	0.22000	-1.24e-01	1.82e-01	9.73e-03	1.61e-04
ERBB2 Activates PTK6 Signaling	8	6.37e-01	7.16e-01	0.22000	1.80e-01	1.27e-01	3.79e-01	5.34e-01
SUMOylation of chromatin organization proteins	57	3.55e-02	8.02e-02	0.21900	-1.05e-01	-1.93e-01	1.69e-01	1.19e-02
Loss of Function of SMAD2/3 in Cancer	7	5.16e-01	6.09e-01	0.21900	6.10e-02	-2.11e-01	7.80e-01	3.34e-01
Cellular responses to mechanical stimuli	82	8.49e-04	3.49e-03	0.21900	-2.70e-02	2.17e-01	6.72e-01	6.74e-04
Response of endothelial cells to shear stress	82	8.49e-04	3.49e-03	0.21900	-2.70e-02	2.17e-01	6.72e-01	6.74e-04
FRS-mediated FGFR4 signaling	13	4.42e-01	5.40e-01	0.21800	7.67e-02	2.04e-01	6.32e-01	2.02e-01
Meiotic synapsis	43	1.65e-02	4.28e-02	0.21800	-2.06e-01	7.10e-02	1.92e-02	4.20e-01
G alpha (z) signalling events	36	6.44e-02	1.25e-01	0.21800	1.42e-02	2.18e-01	8.83e-01	2.38e-02
Interleukin-1 signaling	99	4.19e-05	2.37e-04	0.21800	-1.86e-01	1.14e-01	1.41e-03	5.03e-02
Negative regulation of FGFR1 signaling	25	1.10e-01	1.92e-01	0.21800	-2.14e-01	3.84e-02	6.36e-02	7.39e-01
Extracellular matrix organization	213	2.26e-07	1.77e-06	0.21800	2.95e-02	2.16e-01	4.59e-01	5.70e-08
Apoptosis	157	1.40e-06	9.93e-06	0.21800	-2.16e-01	3.04e-02	3.13e-06	5.11e-01
HS-GAG biosynthesis	19	1.63e-01	2.55e-01	0.21800	-7.38e-02	2.05e-01	5.78e-01	1.22e-01
GPER1 signaling	38	3.27e-02	7.53e-02	0.21700	-4.87e-02	2.12e-01	6.03e-01	2.39e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	1.62e-03	6.04e-03	0.21700	-1.67e-01	1.39e-01	2.29e-02	5.91e-02
Metabolic disorders of biological oxidation enzymes	23	1.28e-01	2.12e-01	0.21700	-2.11e-01	4.78e-02	7.91e-02	6.92e-01
Cell-Cell communication	107	3.42e-03	1.15e-02	0.21700	1.44e-01	1.62e-01	1.01e-02	3.86e-03
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	2.46e-01	3.50e-01	0.21600	4.97e-02	2.10e-01	6.93e-01	9.55e-02
Transcriptional regulation by RUNX3	80	4.11e-04	1.87e-03	0.21600	-1.94e-01	9.47e-02	2.72e-03	1.43e-01
G alpha (q) signalling events	138	5.15e-04	2.25e-03	0.21600	1.15e-01	1.82e-01	1.93e-02	2.17e-04
FLT3 signaling through SRC family kinases	6	6.31e-01	7.11e-01	0.21600	2.16e-01	4.83e-03	3.60e-01	9.84e-01
Glutamate and glutamine metabolism	12	4.26e-01	5.25e-01	0.21600	-2.14e-01	-2.89e-02	2.00e-01	8.62e-01
Basigin interactions	21	1.57e-01	2.48e-01	0.21500	-2.10e-01	4.62e-02	9.52e-02	7.14e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	1.87e-01	2.82e-01	0.21500	-2.15e-01	1.15e-02	8.87e-02	9.28e-01
Prolactin receptor signaling	11	5.55e-01	6.44e-01	0.21500	-1.25e-01	-1.74e-01	4.72e-01	3.16e-01
Ion transport by P-type ATPases	41	1.17e-01	2.00e-01	0.21500	1.48e-01	1.56e-01	1.01e-01	8.47e-02
Asparagine N-linked glycosylation	284	1.87e-12	2.79e-11	0.21400	-1.93e-01	9.29e-02	2.15e-08	7.06e-03
Signaling by VEGF	99	1.66e-04	8.01e-04	0.21400	-5.21e-02	2.08e-01	3.71e-01	3.60e-04
Transcriptional regulation by RUNX1	170	6.29e-08	5.52e-07	0.21400	-1.09e-01	1.84e-01	1.47e-02	3.36e-05
RHOV GTPase cycle	36	1.21e-01	2.05e-01	0.21400	1.97e-01	8.34e-02	4.09e-02	3.87e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	1.40e-02	3.76e-02	0.21400	-1.97e-01	-8.39e-02	3.69e-03	2.15e-01
Keratan sulfate/keratin metabolism	27	1.22e-01	2.06e-01	0.21400	-7.01e-03	2.14e-01	9.50e-01	5.47e-02
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	6.14e-04	2.61e-03	0.21400	-4.90e-02	2.08e-01	4.35e-01	9.25e-04
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	6.14e-04	2.61e-03	0.21400	-4.90e-02	2.08e-01	4.35e-01	9.25e-04
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	6.14e-04	2.61e-03	0.21400	-4.90e-02	2.08e-01	4.35e-01	9.25e-04
SHC1 events in ERBB2 signaling	17	3.32e-01	4.33e-01	0.21300	5.01e-02	2.07e-01	7.20e-01	1.39e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	6.39e-01	7.17e-01	0.21300	2.06e-01	5.42e-02	3.45e-01	8.04e-01
Potential therapeutics for SARS	147	5.35e-07	3.98e-06	0.21300	-1.75e-01	1.21e-01	2.41e-04	1.15e-02
IRS-mediated signalling	35	1.52e-01	2.42e-01	0.21300	1.81e-01	1.12e-01	6.40e-02	2.51e-01
FGFR1 ligand binding and activation	10	5.03e-01	5.95e-01	0.21200	-2.94e-02	-2.10e-01	8.72e-01	2.50e-01
RHOA GTPase cycle	138	1.06e-04	5.43e-04	0.21200	3.79e-02	2.09e-01	4.42e-01	2.33e-05
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	2.27e-02	5.57e-02	0.21200	-2.09e-01	3.20e-02	1.40e-02	7.07e-01
Interleukin-23 signaling	7	5.72e-01	6.59e-01	0.21100	2.10e-01	-2.20e-02	3.35e-01	9.20e-01
Purine salvage	12	3.90e-01	4.91e-01	0.21100	-2.10e-01	1.76e-02	2.08e-01	9.16e-01
RND3 GTPase cycle	35	1.52e-01	2.42e-01	0.21100	1.03e-01	1.84e-01	2.92e-01	5.96e-02
Resolution of Sister Chromatid Cohesion	115	2.13e-05	1.26e-04	0.21000	-1.84e-01	1.01e-01	6.56e-04	6.04e-02
Gap junction degradation	11	4.04e-01	5.05e-01	0.21000	-3.92e-02	2.06e-01	8.22e-01	2.36e-01
Signaling by Interleukins	386	4.07e-11	5.18e-10	0.21000	4.80e-02	2.04e-01	1.06e-01	5.67e-12
NRAGE signals death through JNK	52	7.59e-02	1.42e-01	0.20900	1.46e-01	1.50e-01	6.81e-02	6.17e-02
PI3K Cascade	31	1.85e-01	2.81e-01	0.20900	1.87e-01	9.31e-02	7.08e-02	3.70e-01
TLR3-mediated TICAM1-dependent programmed cell death	6	7.39e-01	7.91e-01	0.20900	1.67e-01	1.25e-01	4.78e-01	5.95e-01
Beta-catenin independent WNT signaling	124	6.74e-06	4.30e-05	0.20900	-1.54e-01	1.41e-01	3.06e-03	6.64e-03
FLT3 Signaling	38	1.10e-01	1.92e-01	0.20800	6.88e-02	1.97e-01	4.63e-01	3.59e-02
SARS-CoV Infections	427	4.91e-13	7.79e-12	0.20800	-2.07e-01	-2.26e-02	2.08e-13	4.24e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	4.19e-01	5.18e-01	0.20800	-1.97e-01	-6.90e-02	1.87e-01	6.44e-01
Drug ADME	55	7.08e-03	2.12e-02	0.20800	-1.90e-01	8.62e-02	1.50e-02	2.69e-01
Glycogen storage diseases	13	4.87e-01	5.82e-01	0.20800	-1.91e-01	-8.30e-02	2.33e-01	6.04e-01
PI3K/AKT Signaling in Cancer	83	1.40e-02	3.76e-02	0.20700	1.06e-01	1.78e-01	9.44e-02	5.00e-03
Tie2 Signaling	16	3.86e-01	4.86e-01	0.20700	5.76e-02	1.99e-01	6.90e-01	1.68e-01
Pyroptosis	24	2.00e-01	3.00e-01	0.20700	-2.06e-01	-2.11e-02	8.04e-02	8.58e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	7.84e-01	8.24e-01	0.20700	-1.43e-01	-1.50e-01	5.81e-01	5.61e-01
IRF3-mediated induction of type I IFN	12	5.38e-01	6.30e-01	0.20700	-1.04e-01	-1.79e-01	5.32e-01	2.83e-01
Keratinization	33	1.07e-01	1.87e-01	0.20700	1.65e-02	2.06e-01	8.70e-01	4.06e-02
Sensory Perception	187	7.01e-05	3.66e-04	0.20700	1.03e-01	1.79e-01	1.55e-02	2.35e-05
Inactivation, recovery and regulation of the phototransduction cascade	25	2.55e-01	3.60e-01	0.20600	-1.90e-01	-7.99e-02	1.00e-01	4.89e-01
Axon guidance	454	2.72e-15	5.69e-14	0.20600	-2.05e-01	1.97e-02	7.00e-14	4.71e-01
Disorders of transmembrane transporters	134	4.80e-05	2.66e-04	0.20600	-2.05e-01	1.74e-02	4.21e-05	7.28e-01
Interferon alpha/beta signaling	63	4.86e-02	1.02e-01	0.20500	-1.59e-01	-1.29e-01	2.90e-02	7.59e-02
Response of Mtb to phagocytosis	22	1.52e-01	2.42e-01	0.20500	-1.90e-01	7.62e-02	1.23e-01	5.36e-01
RHO GTPases Activate Formins	127	2.02e-05	1.21e-04	0.20400	-1.88e-01	7.83e-02	2.47e-04	1.28e-01
Gene Silencing by RNA	87	1.45e-02	3.85e-02	0.20400	-1.70e-01	-1.12e-01	6.08e-03	7.14e-02
Integrin cell surface interactions	64	2.02e-02	5.05e-02	0.20300	3.66e-02	2.00e-01	6.13e-01	5.71e-03
Activation of HOX genes during differentiation	68	1.23e-02	3.40e-02	0.20300	-2.02e-01	-1.93e-02	3.94e-03	7.83e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	68	1.23e-02	3.40e-02	0.20300	-2.02e-01	-1.93e-02	3.94e-03	7.83e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	90	1.38e-03	5.25e-03	0.20300	-2.02e-01	2.13e-02	9.42e-04	7.27e-01
Amplification of signal from the kinetochores	90	1.38e-03	5.25e-03	0.20300	-2.02e-01	2.13e-02	9.42e-04	7.27e-01
Signaling by TGFBR3	39	1.22e-01	2.06e-01	0.20300	1.90e-01	7.18e-02	4.04e-02	4.38e-01
FGFR1 mutant receptor activation	25	2.79e-01	3.87e-01	0.20300	9.05e-02	1.81e-01	4.34e-01	1.16e-01
Activation of the phototransduction cascade	8	6.75e-01	7.44e-01	0.20300	1.74e-01	1.04e-01	3.94e-01	6.11e-01
G alpha (12/13) signalling events	68	2.95e-02	6.94e-02	0.20200	8.26e-02	1.85e-01	2.39e-01	8.49e-03
Cell Cycle, Mitotic	487	1.15e-16	2.67e-15	0.20200	-1.98e-01	4.11e-02	7.97e-14	1.20e-01
Nonhomologous End-Joining (NHEJ)	40	5.48e-02	1.10e-01	0.20200	-2.01e-01	2.12e-02	2.81e-02	8.16e-01
CDC42 GTPase cycle	139	9.97e-04	4.04e-03	0.20200	9.36e-02	1.79e-01	5.67e-02	2.76e-04
Translation of Structural Proteins 9683701	29	1.13e-01	1.95e-01	0.20200	-1.99e-01	3.38e-02	6.39e-02	7.52e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	3.95e-02	8.67e-02	0.20200	-1.49e-01	1.36e-01	1.22e-01	1.58e-01
Cell Cycle	609	5.87e-19	1.71e-17	0.20200	-2.01e-01	1.31e-02	2.30e-17	5.82e-01
Iron uptake and transport	52	2.37e-02	5.76e-02	0.20100	-2.00e-01	2.06e-02	1.26e-02	7.97e-01
EPH-Ephrin signaling	79	1.06e-03	4.22e-03	0.20100	-1.05e-01	1.71e-01	1.06e-01	8.50e-03
RHOD GTPase cycle	49	5.28e-02	1.08e-01	0.20000	3.31e-02	1.98e-01	6.88e-01	1.67e-02
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	3.79e-01	4.80e-01	0.20000	1.50e-01	-1.32e-01	3.89e-01	4.48e-01
Metabolism of amine-derived hormones	10	6.29e-01	7.09e-01	0.20000	1.17e-01	1.62e-01	5.23e-01	3.74e-01
Activation of C3 and C5	7	6.87e-01	7.55e-01	0.20000	-1.89e-01	-6.47e-02	3.87e-01	7.67e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.49e-01	2.38e-01	0.20000	-3.29e-02	-1.97e-01	7.47e-01	5.40e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.49e-01	2.38e-01	0.20000	-3.29e-02	-1.97e-01	7.47e-01	5.40e-02
Signaling by GPCR	435	2.81e-09	2.90e-08	0.19900	1.14e-01	1.63e-01	4.35e-05	5.72e-09
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	1.31e-02	3.54e-02	0.19900	-3.53e-02	1.96e-01	6.39e-01	9.31e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.91e-01	4.92e-01	0.19900	6.90e-02	1.86e-01	6.12e-01	1.71e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	7.05e-08	6.08e-07	0.19800	-1.37e-01	1.43e-01	1.09e-03	6.49e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	4.00e-01	5.00e-01	0.19800	5.24e-02	-1.91e-01	7.53e-01	2.52e-01
Uptake and actions of bacterial toxins	27	1.82e-01	2.78e-01	0.19700	9.06e-03	1.97e-01	9.35e-01	7.65e-02
Integrin signaling	22	1.52e-01	2.42e-01	0.19700	-1.45e-01	1.33e-01	2.38e-01	2.81e-01
FGFR2c ligand binding and activation	5	7.81e-01	8.21e-01	0.19700	7.78e-02	1.81e-01	7.63e-01	4.84e-01
Mitochondrial biogenesis	91	8.82e-03	2.56e-02	0.19600	-1.87e-01	-6.07e-02	2.10e-03	3.17e-01
E2F mediated regulation of DNA replication	22	3.21e-01	4.24e-01	0.19600	-1.86e-01	-6.29e-02	1.32e-01	6.10e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	10	4.69e-01	5.65e-01	0.19600	-1.87e-01	5.74e-02	3.05e-01	7.53e-01
Pre-NOTCH Expression and Processing	63	1.89e-02	4.78e-02	0.19600	4.55e-03	1.96e-01	9.50e-01	7.22e-03
RAB GEFs exchange GTP for GDP on RABs	89	2.37e-03	8.48e-03	0.19600	-1.93e-02	1.95e-01	7.53e-01	1.50e-03
Interleukin-12 signaling	44	2.52e-02	6.10e-02	0.19500	-1.18e-01	1.56e-01	1.77e-01	7.33e-02
FRS-mediated FGFR2 signaling	15	4.98e-01	5.90e-01	0.19500	9.41e-02	1.71e-01	5.28e-01	2.51e-01
Diseases associated with surfactant metabolism	5	7.36e-01	7.89e-01	0.19500	1.23e-02	1.95e-01	9.62e-01	4.50e-01
DAP12 interactions	39	1.85e-01	2.81e-01	0.19500	1.48e-01	1.27e-01	1.10e-01	1.71e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	3.18e-01	4.22e-01	0.19400	1.82e-01	6.81e-02	1.31e-01	5.72e-01
Cell junction organization	76	3.51e-02	7.96e-02	0.19400	1.61e-01	1.09e-01	1.54e-02	1.00e-01
Transport of bile salts and organic acids, metal ions and amine compounds	51	5.78e-02	1.16e-01	0.19400	3.38e-02	1.91e-01	6.76e-01	1.83e-02
Striated Muscle Contraction	25	3.45e-01	4.47e-01	0.19400	1.38e-01	1.36e-01	2.33e-01	2.38e-01
Nervous system development	472	5.43e-14	9.67e-13	0.19400	-1.93e-01	1.54e-02	6.41e-13	5.66e-01
TRIF-mediated programmed cell death	9	5.50e-01	6.40e-01	0.19300	1.92e-01	-1.86e-02	3.17e-01	9.23e-01
NCAM signaling for neurite out-growth	47	8.80e-02	1.59e-01	0.19300	1.86e-01	5.32e-02	2.76e-02	5.28e-01
Signaling by Insulin receptor	63	1.18e-02	3.28e-02	0.19300	-4.07e-02	1.89e-01	5.76e-01	9.58e-03
FGFR3 ligand binding and activation	5	7.84e-01	8.24e-01	0.19300	6.99e-02	1.80e-01	7.86e-01	4.87e-01
FGFR3c ligand binding and activation	5	7.84e-01	8.24e-01	0.19300	6.99e-02	1.80e-01	7.86e-01	4.87e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	6.51e-01	7.26e-01	0.19200	3.76e-02	1.88e-01	8.54e-01	3.58e-01
Assembly of collagen fibrils and other multimeric structures	41	1.81e-01	2.77e-01	0.19100	1.19e-01	1.49e-01	1.87e-01	9.87e-02
CDC6 association with the ORC:origin complex	8	6.66e-01	7.36e-01	0.19100	-1.84e-01	-5.03e-02	3.68e-01	8.06e-01
Activation of BH3-only proteins	29	2.90e-01	3.97e-01	0.19100	-1.59e-01	-1.04e-01	1.38e-01	3.30e-01
Zinc influx into cells by the SLC39 gene family	9	5.85e-01	6.70e-01	0.19000	5.43e-03	1.90e-01	9.77e-01	3.23e-01
Protein-protein interactions at synapses	54	5.10e-02	1.06e-01	0.19000	1.88e-01	2.61e-02	1.66e-02	7.40e-01
The phototransduction cascade	26	3.40e-01	4.41e-01	0.19000	-1.51e-01	-1.14e-01	1.81e-01	3.13e-01
COPII-mediated vesicle transport	67	6.52e-03	1.98e-02	0.18900	-8.44e-02	1.69e-01	2.32e-01	1.66e-02
Estrogen-dependent gene expression	96	3.13e-03	1.07e-02	0.18900	-2.20e-03	1.89e-01	9.70e-01	1.36e-03
PP2A-mediated dephosphorylation of key metabolic factors	7	7.34e-01	7.88e-01	0.18900	8.65e-02	1.68e-01	6.92e-01	4.41e-01
G alpha (s) signalling events	93	1.53e-02	4.02e-02	0.18900	7.82e-02	1.72e-01	1.92e-01	4.19e-03
Ub-specific processing proteases	153	2.32e-05	1.36e-04	0.18800	-1.80e-01	5.58e-02	1.23e-04	2.33e-01
Keratan sulfate degradation	9	6.07e-01	6.90e-01	0.18800	-1.87e-01	-1.90e-02	3.31e-01	9.21e-01
Hedgehog ‘off’ state	90	1.47e-03	5.53e-03	0.18800	-1.73e-01	7.29e-02	4.50e-03	2.32e-01
EML4 and NUDC in mitotic spindle formation	106	4.85e-04	2.16e-03	0.18800	-1.74e-01	7.04e-02	1.95e-03	2.10e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	19	3.21e-01	4.24e-01	0.18800	-4.32e-03	1.88e-01	9.74e-01	1.57e-01
Trafficking of AMPA receptors	19	3.21e-01	4.24e-01	0.18800	-4.32e-03	1.88e-01	9.74e-01	1.57e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	5.94e-01	6.78e-01	0.18700	-1.17e-01	-1.46e-01	4.64e-01	3.63e-01
Non-integrin membrane-ECM interactions	46	3.88e-02	8.57e-02	0.18700	-6.49e-02	1.75e-01	4.46e-01	3.97e-02
Regulation of pyruvate metabolism	32	1.12e-01	1.93e-01	0.18700	-1.79e-01	5.32e-02	7.98e-02	6.03e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	17	4.86e-01	5.82e-01	0.18600	1.64e-01	8.83e-02	2.42e-01	5.29e-01
Mucopolysaccharidoses	11	6.49e-01	7.25e-01	0.18600	-1.28e-01	-1.35e-01	4.63e-01	4.37e-01
GPCR downstream signalling	392	1.23e-07	1.02e-06	0.18600	9.72e-02	1.59e-01	9.63e-04	6.85e-08
Caspase activation via extrinsic apoptotic signalling pathway	25	3.48e-01	4.50e-01	0.18600	1.64e-01	8.81e-02	1.57e-01	4.46e-01
Signaling by NTRK2 (TRKB)	20	4.53e-01	5.49e-01	0.18600	1.15e-01	1.46e-01	3.75e-01	2.58e-01
Signaling by activated point mutants of FGFR1	5	7.78e-01	8.19e-01	0.18600	-1.82e-01	-3.86e-02	4.82e-01	8.81e-01
Opioid Signalling	74	2.98e-02	6.99e-02	0.18600	5.25e-02	1.78e-01	4.35e-01	8.06e-03
Dopamine Neurotransmitter Release Cycle	20	4.40e-01	5.38e-01	0.18600	1.58e-01	9.76e-02	2.22e-01	4.50e-01
Glutamate Neurotransmitter Release Cycle	20	4.50e-01	5.48e-01	0.18600	1.50e-01	1.09e-01	2.45e-01	3.98e-01
TCF dependent signaling in response to WNT	150	4.31e-05	2.42e-04	0.18600	-5.07e-02	1.79e-01	2.84e-01	1.60e-04
RHOBTB2 GTPase cycle	23	1.83e-01	2.79e-01	0.18500	-1.59e-01	9.51e-02	1.86e-01	4.30e-01
Interleukin-12 family signaling	53	1.83e-02	4.66e-02	0.18500	-1.16e-01	1.45e-01	1.45e-01	6.83e-02
SUMOylation of DNA methylation proteins	16	4.20e-01	5.20e-01	0.18500	-1.84e-01	-1.56e-02	2.02e-01	9.14e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	3.08e-01	4.16e-01	0.18500	1.58e-01	-9.58e-02	2.73e-01	5.07e-01
VEGFR2 mediated cell proliferation	18	2.60e-01	3.65e-01	0.18500	-1.08e-01	1.50e-01	4.26e-01	2.71e-01
Stimuli-sensing channels	78	3.82e-02	8.48e-02	0.18500	8.58e-02	1.64e-01	1.90e-01	1.25e-02
Negative regulation of FGFR2 signaling	24	1.92e-01	2.90e-01	0.18500	-1.74e-01	6.24e-02	1.41e-01	5.97e-01
Deadenylation of mRNA	22	4.28e-01	5.26e-01	0.18500	-1.35e-01	-1.26e-01	2.74e-01	3.06e-01
Regulation of TP53 Activity through Phosphorylation	88	1.61e-02	4.18e-02	0.18400	-1.77e-01	-5.14e-02	4.07e-03	4.04e-01
CRMPs in Sema3A signaling	13	5.60e-01	6.50e-01	0.18400	6.54e-02	1.72e-01	6.83e-01	2.83e-01
Elastic fibre formation	33	1.85e-01	2.81e-01	0.18400	2.72e-02	1.82e-01	7.86e-01	7.06e-02
HDACs deacetylate histones	45	3.91e-02	8.62e-02	0.18300	-1.58e-01	9.32e-02	6.69e-02	2.80e-01
MET promotes cell motility	31	1.27e-01	2.12e-01	0.18300	-5.56e-02	1.74e-01	5.92e-01	9.27e-02
Acyl chain remodeling of CL	5	8.04e-01	8.39e-01	0.18300	1.70e-01	6.69e-02	5.09e-01	7.96e-01
CLEC7A (Dectin-1) signaling	85	4.10e-03	1.34e-02	0.18300	-1.77e-01	4.64e-02	4.79e-03	4.60e-01
Mitotic Prophase	96	3.38e-03	1.14e-02	0.18300	-1.82e-01	1.80e-02	2.06e-03	7.60e-01
Programmed Cell Death	186	7.02e-06	4.45e-05	0.18300	-1.77e-01	4.38e-02	3.00e-05	3.03e-01
Signaling by NOTCH	173	3.09e-06	2.11e-05	0.18300	-1.31e-01	1.27e-01	2.95e-03	3.87e-03
Transcriptional regulation of white adipocyte differentiation	77	5.47e-02	1.10e-01	0.18200	1.20e-01	1.37e-01	6.87e-02	3.72e-02
Maternal to zygotic transition (MZT)	71	5.66e-03	1.77e-02	0.18200	-1.29e-01	1.28e-01	6.08e-02	6.17e-02
NGF-stimulated transcription	32	2.47e-01	3.50e-01	0.18100	1.71e-01	5.97e-02	9.44e-02	5.59e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	10	5.23e-01	6.15e-01	0.18100	-5.40e-02	1.73e-01	7.67e-01	3.45e-01
Signaling by NOTCH3	42	6.99e-02	1.34e-01	0.18100	-4.69e-02	1.74e-01	5.99e-01	5.04e-02
Neuronal System	261	6.15e-05	3.29e-04	0.18000	1.08e-01	1.45e-01	2.72e-03	5.80e-05
Synthesis of very long-chain fatty acyl-CoAs	22	2.18e-01	3.21e-01	0.18000	-8.81e-02	1.57e-01	4.74e-01	2.02e-01
Fatty acyl-CoA biosynthesis	35	9.64e-02	1.71e-01	0.18000	-7.09e-02	1.65e-01	4.68e-01	9.03e-02
HSF1-dependent transactivation	28	1.84e-01	2.80e-01	0.18000	-3.30e-02	1.77e-01	7.63e-01	1.05e-01
SUMOylation of DNA replication proteins	46	1.86e-01	2.82e-01	0.18000	-1.28e-01	-1.26e-01	1.33e-01	1.38e-01
WNT ligand biogenesis and trafficking	19	3.76e-01	4.78e-01	0.18000	1.79e-01	1.28e-02	1.76e-01	9.23e-01
Membrane Trafficking	575	7.80e-18	2.03e-16	0.18000	-1.02e-01	1.48e-01	2.75e-05	1.49e-09
Reelin signalling pathway	5	8.13e-01	8.47e-01	0.17900	6.95e-02	1.65e-01	7.88e-01	5.23e-01
RHOQ GTPase cycle	54	5.13e-02	1.06e-01	0.17900	-7.50e-03	1.79e-01	9.24e-01	2.30e-02
ESR-mediated signaling	157	1.04e-04	5.32e-04	0.17900	-2.82e-02	1.76e-01	5.42e-01	1.36e-04
Interleukin-1 family signaling	127	1.60e-04	7.79e-04	0.17800	-1.03e-01	1.45e-01	4.51e-02	4.71e-03
CD28 dependent PI3K/Akt signaling	22	2.17e-01	3.20e-01	0.17800	1.07e-01	-1.42e-01	3.83e-01	2.49e-01
Glycogen metabolism	21	2.81e-01	3.89e-01	0.17800	-1.73e-01	4.00e-02	1.69e-01	7.51e-01
FGFR2 ligand binding and activation	9	6.04e-01	6.87e-01	0.17700	1.77e-02	-1.76e-01	9.27e-01	3.59e-01
G alpha (i) signalling events	193	1.07e-04	5.46e-04	0.17700	2.56e-02	1.75e-01	5.39e-01	2.63e-05
Cytochrome P450 - arranged by substrate type	33	2.83e-01	3.90e-01	0.17700	8.37e-02	1.56e-01	4.05e-01	1.21e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	3.08e-01	4.16e-01	0.17700	-1.77e-01	6.46e-03	1.51e-01	9.58e-01
Early SARS-CoV-2 Infection Events	30	1.35e-01	2.23e-01	0.17600	-1.53e-01	8.83e-02	1.48e-01	4.02e-01
Formation of the Editosome	6	7.97e-01	8.35e-01	0.17600	8.53e-02	1.54e-01	7.18e-01	5.12e-01
mRNA Editing: C to U Conversion	6	7.97e-01	8.35e-01	0.17600	8.53e-02	1.54e-01	7.18e-01	5.12e-01
Attachment of GPI anchor to uPAR	7	6.24e-01	7.04e-01	0.17600	-1.02e-01	1.43e-01	6.40e-01	5.13e-01
Plasma lipoprotein clearance	33	1.45e-01	2.33e-01	0.17500	-1.71e-01	3.87e-02	8.90e-02	7.00e-01
FGFR2b ligand binding and activation	6	6.68e-01	7.38e-01	0.17500	1.06e-01	-1.39e-01	6.52e-01	5.55e-01
Oxidative Stress Induced Senescence	77	5.62e-03	1.76e-02	0.17500	-1.21e-01	1.26e-01	6.55e-02	5.69e-02
Post-translational modification: synthesis of GPI-anchored proteins	57	1.42e-01	2.30e-01	0.17400	-1.24e-01	-1.23e-01	1.06e-01	1.09e-01
Transcription of E2F targets under negative control by DREAM complex	19	3.07e-01	4.15e-01	0.17400	-6.62e-02	1.61e-01	6.17e-01	2.24e-01
Defective B3GAT3 causes JDSSDHD	10	5.69e-01	6.55e-01	0.17400	-3.13e-02	1.71e-01	8.64e-01	3.49e-01
FGFR1c ligand binding and activation	8	7.57e-01	8.05e-01	0.17400	-1.05e-01	-1.38e-01	6.06e-01	4.98e-01
Neurotransmitter receptors and postsynaptic signal transmission	132	6.59e-03	1.99e-02	0.17300	7.05e-02	1.58e-01	1.62e-01	1.67e-03
Signaling by CSF3 (G-CSF)	29	3.02e-01	4.10e-01	0.17300	4.99e-02	1.66e-01	6.42e-01	1.22e-01
IRAK2 mediated activation of TAK1 complex	10	6.92e-01	7.57e-01	0.17300	-1.54e-01	-7.96e-02	4.00e-01	6.63e-01
RUNX2 regulates bone development	21	4.16e-01	5.15e-01	0.17300	4.55e-02	1.67e-01	7.18e-01	1.86e-01
Ion channel transport	136	5.29e-03	1.67e-02	0.17300	6.47e-02	1.60e-01	1.93e-01	1.26e-03
TGF-beta receptor signaling activates SMADs	45	5.26e-02	1.08e-01	0.17300	-1.08e-01	1.35e-01	2.12e-01	1.17e-01
Xenobiotics	9	7.00e-01	7.62e-01	0.17200	1.63e-01	5.54e-02	3.98e-01	7.73e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	2.88e-01	3.95e-01	0.17100	-1.71e-01	3.79e-03	1.38e-01	9.74e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	2.88e-01	3.95e-01	0.17100	-1.71e-01	3.79e-03	1.38e-01	9.74e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	2.88e-01	3.95e-01	0.17100	-1.71e-01	3.79e-03	1.38e-01	9.74e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	2.88e-01	3.95e-01	0.17100	-1.71e-01	3.79e-03	1.38e-01	9.74e-01
Neurotransmitter release cycle	38	2.84e-01	3.91e-01	0.17100	1.26e-01	1.16e-01	1.80e-01	2.17e-01
AKT phosphorylates targets in the nucleus	9	5.64e-01	6.52e-01	0.17100	1.40e-01	-9.74e-02	4.66e-01	6.13e-01
SUMOylation of DNA damage response and repair proteins	77	5.99e-02	1.19e-01	0.17000	-7.14e-02	-1.55e-01	2.79e-01	1.89e-02
Cyclin D associated events in G1	47	5.23e-02	1.07e-01	0.17000	-1.43e-01	9.28e-02	9.01e-02	2.71e-01
G1 Phase	47	5.23e-02	1.07e-01	0.17000	-1.43e-01	9.28e-02	9.01e-02	2.71e-01
Histidine catabolism	7	7.27e-01	7.84e-01	0.17000	1.69e-01	1.56e-02	4.38e-01	9.43e-01
Sperm Motility And Taxes	6	7.72e-01	8.15e-01	0.17000	-1.67e-01	-2.79e-02	4.78e-01	9.06e-01
Downregulation of TGF-beta receptor signaling	26	2.12e-01	3.15e-01	0.16900	-1.54e-01	7.00e-02	1.73e-01	5.37e-01
Signaling by MET	66	4.91e-02	1.03e-01	0.16900	1.09e-02	1.69e-01	8.79e-01	1.79e-02
Signaling by FGFR2	61	9.02e-02	1.63e-01	0.16900	-1.62e-01	-4.66e-02	2.84e-02	5.29e-01
RND2 GTPase cycle	36	3.13e-01	4.20e-01	0.16900	1.26e-01	1.12e-01	1.92e-01	2.43e-01
Insulin receptor signalling cascade	40	2.64e-01	3.69e-01	0.16800	9.31e-02	1.40e-01	3.08e-01	1.25e-01
Ion homeostasis	40	2.00e-01	3.00e-01	0.16800	3.97e-02	1.63e-01	6.64e-01	7.37e-02
TICAM1, RIP1-mediated IKK complex recruitment	19	3.18e-01	4.22e-01	0.16800	-8.29e-02	1.46e-01	5.32e-01	2.70e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	7.49e-01	7.98e-01	0.16700	8.00e-03	-1.67e-01	9.73e-01	4.79e-01
TGFBR1 KD Mutants in Cancer	6	7.49e-01	7.98e-01	0.16700	8.00e-03	-1.67e-01	9.73e-01	4.79e-01
PI5P Regulates TP53 Acetylation	8	7.74e-01	8.16e-01	0.16700	1.03e-01	1.32e-01	6.15e-01	5.19e-01
Cytosolic sulfonation of small molecules	18	4.24e-01	5.23e-01	0.16700	-1.67e-01	5.64e-03	2.20e-01	9.67e-01
AKT phosphorylates targets in the cytosol	14	4.62e-01	5.58e-01	0.16600	-5.15e-02	1.58e-01	7.39e-01	3.05e-01
Innate Immune System	965	2.21e-24	8.66e-23	0.16600	-8.24e-02	1.44e-01	1.48e-05	3.41e-14
PKMTs methylate histone lysines	42	2.07e-01	3.09e-01	0.16600	1.58e-01	5.04e-02	7.61e-02	5.72e-01
Regulation of HSF1-mediated heat shock response	78	6.43e-02	1.25e-01	0.16600	-1.52e-01	-6.58e-02	2.00e-02	3.15e-01
Acyl chain remodelling of PS	14	6.22e-01	7.03e-01	0.16600	7.66e-02	1.47e-01	6.20e-01	3.40e-01
Synthesis of substrates in N-glycan biosythesis	58	9.55e-02	1.70e-01	0.16600	-1.63e-01	-3.11e-02	3.18e-02	6.82e-01
PTEN Regulation	126	1.24e-03	4.82e-03	0.16600	-1.60e-01	4.28e-02	1.91e-03	4.07e-01
Regulation of TP53 Degradation	35	3.00e-01	4.10e-01	0.16600	-1.50e-01	-7.13e-02	1.26e-01	4.66e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	7.01e-01	7.63e-01	0.16600	-8.71e-03	-1.65e-01	9.66e-01	4.18e-01
Synthesis of IP3 and IP4 in the cytosol	22	4.99e-01	5.91e-01	0.16600	1.32e-01	1.00e-01	2.84e-01	4.17e-01
RHO GTPase cycle	408	5.20e-07	3.89e-06	0.16500	5.77e-02	1.55e-01	4.54e-02	7.79e-08
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	2.47e-01	3.50e-01	0.16500	-1.61e-01	3.54e-02	1.47e-01	7.50e-01
Apoptotic execution phase	46	6.27e-02	1.23e-01	0.16500	-1.20e-01	1.13e-01	1.58e-01	1.85e-01
ER Quality Control Compartment (ERQC)	21	3.87e-01	4.87e-01	0.16400	-1.64e-01	-1.53e-04	1.92e-01	9.99e-01
Diseases associated with glycosaminoglycan metabolism	24	2.82e-01	3.89e-01	0.16400	-1.58e-01	4.43e-02	1.79e-01	7.07e-01
MAPK1/MAPK3 signaling	227	7.82e-06	4.93e-05	0.16400	-4.12e-02	1.59e-01	2.84e-01	3.61e-05
Plasma lipoprotein assembly, remodeling, and clearance	56	3.60e-02	8.13e-02	0.16400	-1.03e-01	1.28e-01	1.82e-01	9.77e-02
MAPK family signaling cascades	259	5.65e-06	3.66e-05	0.16400	-1.12e-02	1.64e-01	7.56e-01	5.55e-06
HATs acetylate histones	92	2.37e-02	5.76e-02	0.16400	-1.62e-01	-2.48e-02	7.08e-03	6.81e-01
Regulation of FOXO transcriptional activity by acetylation	10	7.35e-01	7.88e-01	0.16400	1.03e-01	1.28e-01	5.74e-01	4.83e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	182	2.26e-05	1.33e-04	0.16400	-1.21e-01	1.10e-01	4.92e-03	1.02e-02
Extra-nuclear estrogen signaling	65	4.89e-02	1.02e-01	0.16300	-1.05e-02	1.63e-01	8.83e-01	2.30e-02
ERKs are inactivated	13	5.63e-01	6.52e-01	0.16300	-1.63e-01	-2.07e-03	3.08e-01	9.90e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	619	9.14e-14	1.57e-12	0.16300	-3.15e-02	1.60e-01	1.81e-01	1.12e-11
Signaling by Rho GTPases	603	4.20e-13	6.78e-12	0.16300	-2.44e-02	1.61e-01	3.06e-01	1.49e-11
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	6.65e-01	7.36e-01	0.16200	-6.39e-03	1.62e-01	9.74e-01	3.99e-01
Sphingolipid metabolism	91	7.04e-03	2.12e-02	0.16200	-1.49e-01	6.56e-02	1.43e-02	2.79e-01
Blood group systems biosynthesis	16	4.71e-01	5.66e-01	0.16200	1.73e-02	-1.61e-01	9.04e-01	2.64e-01
Downregulation of ERBB2 signaling	24	4.90e-01	5.84e-01	0.16200	-1.16e-01	-1.13e-01	3.26e-01	3.36e-01
MITF-M-dependent gene expression	81	4.87e-02	1.02e-01	0.16200	3.78e-02	1.57e-01	5.56e-01	1.43e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	2.31e-01	3.34e-01	0.16100	-1.61e-01	-1.61e-02	9.56e-02	8.67e-01
Disease	1605	9.54e-30	4.26e-28	0.16100	-1.60e-01	9.55e-03	8.47e-27	5.24e-01
Heme biosynthesis	13	6.73e-01	7.42e-01	0.16100	-8.68e-02	-1.35e-01	5.88e-01	3.99e-01
MET activates PTK2 signaling	21	3.16e-01	4.21e-01	0.16000	-7.80e-02	1.40e-01	5.36e-01	2.66e-01
Cytosolic sensors of pathogen-associated DNA	63	1.49e-01	2.39e-01	0.16000	-1.34e-01	-8.76e-02	6.53e-02	2.29e-01
Interleukin-35 Signalling	12	6.11e-01	6.92e-01	0.16000	1.13e-02	1.60e-01	9.46e-01	3.38e-01
Fatty acid metabolism	152	3.40e-03	1.15e-02	0.16000	-1.57e-01	-3.12e-02	8.28e-04	5.07e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	7.00e-01	7.63e-01	0.16000	-1.59e-01	-1.96e-02	4.09e-01	9.19e-01
Synthesis of PC	23	3.82e-01	4.83e-01	0.16000	-1.60e-01	-5.84e-03	1.84e-01	9.61e-01
Apoptotic cleavage of cell adhesion proteins	8	6.39e-01	7.17e-01	0.16000	-9.52e-02	1.29e-01	6.41e-01	5.29e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	7.58e-01	8.05e-01	0.16000	1.35e-01	-8.63e-02	6.02e-01	7.38e-01
Signaling by BRAF and RAF1 fusions	59	4.77e-02	1.00e-01	0.16000	-1.50e-01	5.51e-02	4.62e-02	4.64e-01
Defective RIPK1-mediated regulated necrosis	7	7.12e-01	7.72e-01	0.16000	3.47e-02	-1.56e-01	8.74e-01	4.75e-01
Reproduction	84	1.84e-02	4.66e-02	0.16000	-1.57e-01	3.04e-02	1.31e-02	6.30e-01
WNT mediated activation of DVL	8	7.67e-01	8.11e-01	0.15900	5.89e-02	1.48e-01	7.73e-01	4.68e-01
Impaired BRCA2 binding to PALB2	24	3.71e-01	4.75e-01	0.15900	-1.59e-01	-6.76e-03	1.77e-01	9.54e-01
Signaling by WNT	236	1.14e-05	7.07e-05	0.15900	-3.78e-02	1.55e-01	3.17e-01	4.27e-05
RAF/MAP kinase cascade	222	1.67e-05	1.01e-04	0.15900	-4.64e-02	1.52e-01	2.33e-01	9.27e-05
RAC3 GTPase cycle	86	5.24e-02	1.07e-01	0.15900	4.67e-02	1.51e-01	4.54e-01	1.52e-02
Synthesis of pyrophosphates in the cytosol	8	7.66e-01	8.11e-01	0.15800	-5.28e-02	-1.49e-01	7.96e-01	4.66e-01
Transport and synthesis of PAPS	6	7.87e-01	8.26e-01	0.15700	-1.57e-01	-8.25e-03	5.06e-01	9.72e-01
Nuclear Pore Complex (NPC) Disassembly	36	2.90e-01	3.97e-01	0.15700	-4.16e-02	-1.51e-01	6.66e-01	1.16e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	7.93e-01	8.31e-01	0.15700	-3.16e-02	1.54e-01	9.03e-01	5.52e-01
Transmission across Chemical Synapses	179	5.71e-03	1.78e-02	0.15700	8.42e-02	1.32e-01	5.20e-02	2.29e-03
Biological oxidations	135	7.18e-03	2.15e-02	0.15700	-1.55e-01	-2.58e-02	1.93e-03	6.04e-01
G beta:gamma signalling through CDC42	17	4.31e-01	5.30e-01	0.15700	-5.31e-02	1.47e-01	7.05e-01	2.93e-01
RSK activation	7	6.84e-01	7.53e-01	0.15700	-1.12e-01	1.10e-01	6.09e-01	6.15e-01
RNA polymerase II transcribes snRNA genes	71	1.13e-01	1.95e-01	0.15600	-1.42e-01	-6.63e-02	3.90e-02	3.34e-01
Antiviral mechanism by IFN-stimulated genes	140	1.44e-02	3.83e-02	0.15600	-1.41e-01	-6.62e-02	4.01e-03	1.76e-01
Apoptotic cleavage of cellular proteins	35	2.05e-01	3.07e-01	0.15500	-2.96e-02	1.53e-01	7.62e-01	1.18e-01
Adipogenesis	95	7.41e-02	1.40e-01	0.15500	1.18e-01	1.01e-01	4.65e-02	8.97e-02
Cytoprotection by HMOX1	53	7.17e-02	1.36e-01	0.15500	-6.14e-02	1.43e-01	4.39e-01	7.25e-02
Defensins	8	7.21e-01	7.78e-01	0.15500	-1.55e-01	4.08e-03	4.47e-01	9.84e-01
Signaling by NTRKs	116	2.54e-02	6.12e-02	0.15500	5.17e-02	1.46e-01	3.36e-01	6.75e-03
DAP12 signaling	28	4.67e-01	5.64e-01	0.15400	9.77e-02	1.19e-01	3.71e-01	2.75e-01
Clathrin-mediated endocytosis	127	1.41e-03	5.35e-03	0.15300	-1.13e-01	1.03e-01	2.74e-02	4.46e-02
Dermatan sulfate biosynthesis	6	7.34e-01	7.88e-01	0.15300	-9.79e-02	1.18e-01	6.78e-01	6.18e-01
Receptor-type tyrosine-protein phosphatases	11	7.27e-01	7.84e-01	0.15200	1.37e-01	6.68e-02	4.31e-01	7.01e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	3.47e-01	4.49e-01	0.15200	-1.44e-01	-4.88e-02	1.46e-01	6.22e-01
Toll Like Receptor 4 (TLR4) Cascade	138	2.27e-02	5.57e-02	0.15200	7.69e-02	1.31e-01	1.19e-01	8.08e-03
HS-GAG degradation	18	5.77e-01	6.62e-01	0.15100	-5.10e-02	-1.43e-01	7.08e-01	2.95e-01
HDR through Single Strand Annealing (SSA)	37	3.78e-01	4.79e-01	0.15100	-9.31e-02	-1.19e-01	3.27e-01	2.09e-01
Signaling by Receptor Tyrosine Kinases	441	4.35e-08	3.89e-07	0.15100	-5.83e-03	1.51e-01	8.34e-01	5.35e-08
Diseases of mitotic cell cycle	38	2.61e-01	3.66e-01	0.15100	-1.50e-01	-1.70e-02	1.09e-01	8.56e-01
Glycogen breakdown (glycogenolysis)	12	6.85e-01	7.54e-01	0.15100	4.26e-02	1.45e-01	7.98e-01	3.85e-01
PPARA activates gene expression	105	4.24e-02	9.16e-02	0.15100	5.06e-02	1.42e-01	3.70e-01	1.20e-02
Rab regulation of trafficking	122	7.37e-03	2.19e-02	0.15000	-1.88e-02	1.48e-01	7.20e-01	4.64e-03
Regulation of signaling by NODAL	6	7.46e-01	7.97e-01	0.15000	1.21e-01	-8.72e-02	6.06e-01	7.11e-01
Bacterial Infection Pathways	65	4.39e-02	9.39e-02	0.14900	-8.14e-02	1.25e-01	2.56e-01	8.15e-02
Cellular response to heat stress	92	6.78e-02	1.30e-01	0.14900	-1.40e-01	-5.18e-02	2.05e-02	3.90e-01
Recruitment of NuMA to mitotic centrosomes	88	2.78e-02	6.60e-02	0.14900	-1.47e-01	2.42e-02	1.74e-02	6.95e-01
Assembly and cell surface presentation of NMDA receptors	30	4.71e-01	5.66e-01	0.14900	9.83e-02	1.12e-01	3.52e-01	2.90e-01
RUNX2 regulates genes involved in cell migration	6	7.47e-01	7.97e-01	0.14800	1.11e-01	-9.82e-02	6.37e-01	6.77e-01
SHC-mediated cascade:FGFR4	11	7.28e-01	7.85e-01	0.14800	5.29e-02	1.38e-01	7.61e-01	4.27e-01
Ovarian tumor domain proteases	37	3.98e-01	4.98e-01	0.14800	9.83e-02	1.11e-01	3.01e-01	2.43e-01
SHC-mediated cascade:FGFR3	10	7.05e-01	7.65e-01	0.14800	1.10e-02	1.48e-01	9.52e-01	4.19e-01
Regulation of TP53 Expression and Degradation	36	3.41e-01	4.42e-01	0.14800	-1.41e-01	-4.45e-02	1.42e-01	6.44e-01
Signal Transduction	2026	8.82e-27	3.60e-25	0.14800	2.52e-02	1.46e-01	6.17e-02	2.80e-27
Cellular Senescence	142	1.18e-03	4.63e-03	0.14700	-1.11e-01	9.67e-02	2.27e-02	4.67e-02
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	4.31e-01	5.30e-01	0.14700	1.24e-01	-7.92e-02	3.63e-01	5.61e-01
MTOR signalling	39	3.51e-01	4.53e-01	0.14700	-1.32e-01	-6.41e-02	1.54e-01	4.89e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	7.65e-01	8.11e-01	0.14600	1.55e-02	-1.45e-01	9.43e-01	5.05e-01
Crosslinking of collagen fibrils	12	6.54e-01	7.27e-01	0.14600	1.46e-01	2.01e-03	3.81e-01	9.90e-01
Glycosaminoglycan metabolism	95	2.69e-02	6.41e-02	0.14600	-1.76e-02	1.45e-01	7.67e-01	1.49e-02
Sensory processing of sound by inner hair cells of the cochlea	54	2.74e-01	3.81e-01	0.14500	1.09e-01	9.67e-02	1.68e-01	2.19e-01
Mitotic Prometaphase	192	3.53e-04	1.64e-03	0.14500	-1.38e-01	4.34e-02	9.37e-04	3.00e-01
Miscellaneous transport and binding events	20	3.95e-01	4.95e-01	0.14500	-9.83e-02	1.07e-01	4.47e-01	4.09e-01
TP53 Regulates Transcription of Cell Cycle Genes	47	1.76e-01	2.71e-01	0.14500	-1.26e-02	1.44e-01	8.81e-01	8.72e-02
Cargo recognition for clathrin-mediated endocytosis	88	4.23e-02	9.16e-02	0.14500	-1.44e-01	6.98e-03	1.92e-02	9.10e-01
Resolution of D-Loop Structures	35	3.36e-01	4.37e-01	0.14400	-1.42e-01	-2.40e-02	1.45e-01	8.06e-01
Defective B4GALT7 causes EDS, progeroid type	10	6.58e-01	7.29e-01	0.14400	-4.81e-02	1.36e-01	7.92e-01	4.57e-01
Collagen formation	63	1.53e-01	2.44e-01	0.14400	3.23e-02	1.40e-01	6.58e-01	5.39e-02
Regulation of lipid metabolism by PPARalpha	107	6.49e-02	1.26e-01	0.14400	6.40e-02	1.29e-01	2.53e-01	2.14e-02
Metabolism of vitamins and cofactors	163	5.69e-03	1.77e-02	0.14300	-1.43e-01	-1.62e-02	1.69e-03	7.22e-01
EPHA-mediated growth cone collapse	21	5.28e-01	6.20e-01	0.14300	2.56e-02	1.41e-01	8.39e-01	2.64e-01
Signaling by ERBB4	45	2.08e-01	3.10e-01	0.14300	-4.86e-03	1.43e-01	9.55e-01	9.74e-02
SUMOylation of intracellular receptors	26	5.44e-01	6.34e-01	0.14300	8.61e-02	1.14e-01	4.48e-01	3.16e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	5.42e-01	6.33e-01	0.14200	5.86e-02	1.29e-01	6.19e-01	2.73e-01
RAB geranylgeranylation	61	6.89e-02	1.32e-01	0.14200	-8.24e-02	1.15e-01	2.66e-01	1.19e-01
Regulation of MITF-M-dependent genes involved in pigmentation	35	4.51e-01	5.48e-01	0.14200	1.01e-01	9.91e-02	2.99e-01	3.10e-01
Impaired BRCA2 binding to RAD51	35	4.49e-01	5.47e-01	0.14200	-8.97e-02	-1.10e-01	3.59e-01	2.62e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	5.39e-01	6.30e-01	0.14100	1.01e-01	-9.85e-02	5.12e-01	5.23e-01
Neurotoxicity of clostridium toxins	9	7.51e-01	8.00e-01	0.14100	1.41e-01	9.92e-03	4.65e-01	9.59e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	3.94e-04	1.80e-03	0.14100	-1.38e-01	-2.99e-02	8.33e-05	3.94e-01
Signaling by FGFR3	32	3.24e-01	4.27e-01	0.14100	-1.41e-02	1.40e-01	8.90e-01	1.71e-01
Signaling by NTRK1 (TRKA)	102	6.93e-02	1.33e-01	0.14000	4.72e-02	1.32e-01	4.10e-01	2.09e-02
Formation of WDR5-containing histone-modifying complexes	42	1.82e-01	2.78e-01	0.14000	5.55e-02	-1.29e-01	5.34e-01	1.49e-01
CaMK IV-mediated phosphorylation of CREB	8	7.98e-01	8.35e-01	0.14000	-3.19e-02	-1.37e-01	8.76e-01	5.04e-01
Sensing of DNA Double Strand Breaks	6	7.72e-01	8.15e-01	0.14000	8.66e-02	-1.10e-01	7.13e-01	6.40e-01
Peptide hormone metabolism	52	2.42e-01	3.47e-01	0.14000	3.78e-02	1.35e-01	6.38e-01	9.26e-02
G beta:gamma signalling through PLC beta	17	4.93e-01	5.87e-01	0.14000	-6.61e-02	1.23e-01	6.37e-01	3.78e-01
Presynaptic function of Kainate receptors	17	4.93e-01	5.87e-01	0.14000	-6.61e-02	1.23e-01	6.37e-01	3.78e-01
Negative regulation of FLT3	15	5.94e-01	6.78e-01	0.14000	-1.28e-02	1.39e-01	9.31e-01	3.50e-01
Regulation of TLR by endogenous ligand	15	6.93e-01	7.57e-01	0.14000	1.26e-01	6.11e-02	3.98e-01	6.82e-01
Signaling by TGFB family members	137	3.22e-02	7.46e-02	0.14000	5.32e-02	1.29e-01	2.82e-01	9.06e-03
Regulation of FZD by ubiquitination	15	7.08e-01	7.68e-01	0.13900	1.17e-01	7.53e-02	4.31e-01	6.13e-01
Transcriptional regulation of brown and beige adipocyte differentiation	23	5.17e-01	6.09e-01	0.13900	1.37e-01	2.50e-02	2.56e-01	8.35e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	23	5.17e-01	6.09e-01	0.13900	1.37e-01	2.50e-02	2.56e-01	8.35e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	36	3.62e-01	4.65e-01	0.13900	-1.36e-01	-2.72e-02	1.58e-01	7.78e-01
Synthesis of 5-eicosatetraenoic acids	7	8.54e-01	8.80e-01	0.13900	-7.73e-02	-1.15e-01	7.23e-01	5.99e-01
Uptake of dietary cobalamins into enterocytes	5	8.47e-01	8.76e-01	0.13800	-6.85e-03	1.38e-01	9.79e-01	5.92e-01
Signaling by Hedgehog	119	7.13e-03	2.13e-02	0.13800	-1.12e-01	8.06e-02	3.45e-02	1.29e-01
Vitamin D (calciferol) metabolism	10	6.87e-01	7.55e-01	0.13800	-1.32e-01	3.97e-02	4.69e-01	8.28e-01
Glucagon-type ligand receptors	19	4.59e-01	5.55e-01	0.13800	-7.24e-02	1.17e-01	5.85e-01	3.76e-01
TCR signaling	110	2.55e-02	6.13e-02	0.13700	-1.37e-01	1.35e-02	1.33e-02	8.07e-01
Loss of Function of TGFBR1 in Cancer	7	8.51e-01	8.77e-01	0.13700	-6.41e-02	-1.21e-01	7.69e-01	5.78e-01
Synthesis of PIPs at the late endosome membrane	11	6.36e-01	7.15e-01	0.13700	1.08e-01	-8.41e-02	5.35e-01	6.29e-01
AURKA Activation by TPX2	72	5.95e-02	1.18e-01	0.13700	-1.23e-01	5.98e-02	7.09e-02	3.80e-01
FOXO-mediated transcription of cell death genes	16	6.56e-01	7.28e-01	0.13700	3.49e-02	1.32e-01	8.09e-01	3.59e-01
Phospholipase C-mediated cascade: FGFR1	8	7.38e-01	7.91e-01	0.13700	4.82e-02	-1.28e-01	8.13e-01	5.31e-01
Creatine metabolism	6	8.76e-01	8.96e-01	0.13600	7.21e-02	1.16e-01	7.60e-01	6.23e-01
Sensory processing of sound	57	3.02e-01	4.10e-01	0.13600	9.13e-02	1.01e-01	2.33e-01	1.87e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	5.77e-01	6.62e-01	0.13600	-2.29e-02	1.34e-01	8.74e-01	3.53e-01
Signaling by NODAL	15	6.44e-01	7.20e-01	0.13600	-1.36e-01	-1.13e-02	3.63e-01	9.39e-01
Signaling by Nuclear Receptors	210	8.91e-04	3.63e-03	0.13600	-2.03e-02	1.34e-01	6.12e-01	8.06e-04
CTLA4 inhibitory signaling	21	4.72e-01	5.68e-01	0.13500	1.31e-01	-3.60e-02	3.00e-01	7.75e-01
OAS antiviral response	8	8.47e-01	8.76e-01	0.13500	-9.31e-02	-9.82e-02	6.48e-01	6.30e-01
Metabolism of steroids	120	2.25e-02	5.54e-02	0.13500	-8.75e-03	1.35e-01	8.69e-01	1.08e-02
TRAF6 mediated NF-kB activation	23	4.47e-01	5.45e-01	0.13500	1.31e-01	-3.21e-02	2.77e-01	7.90e-01
CD28 dependent Vav1 pathway	12	7.15e-01	7.73e-01	0.13500	1.34e-01	1.62e-02	4.23e-01	9.23e-01
PKR-mediated signaling	67	9.72e-02	1.73e-01	0.13500	-1.31e-01	3.26e-02	6.46e-02	6.45e-01
SHC-mediated cascade:FGFR2	13	7.61e-01	8.07e-01	0.13400	7.66e-02	1.10e-01	6.32e-01	4.91e-01
Lysine catabolism	10	7.57e-01	8.05e-01	0.13400	1.59e-02	1.33e-01	9.31e-01	4.66e-01
Signaling by FGFR2 in disease	33	4.90e-01	5.84e-01	0.13300	-1.17e-01	-6.30e-02	2.44e-01	5.31e-01
Phospholipase C-mediated cascade; FGFR2	8	8.01e-01	8.37e-01	0.13300	1.32e-01	1.21e-02	5.17e-01	9.53e-01
Regulation of localization of FOXO transcription factors	11	6.57e-01	7.29e-01	0.13200	-1.07e-01	7.77e-02	5.39e-01	6.56e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	3.65e-01	4.68e-01	0.13100	1.12e-01	6.89e-02	1.75e-01	4.04e-01
Acetylcholine Neurotransmitter Release Cycle	11	6.70e-01	7.40e-01	0.13100	1.18e-01	-5.84e-02	4.99e-01	7.37e-01
Transcriptional Regulation by TP53	343	1.85e-04	8.93e-04	0.13100	-1.29e-01	-2.44e-02	4.05e-05	4.38e-01
Toll-like Receptor Cascades	162	3.13e-02	7.28e-02	0.13100	5.62e-02	1.18e-01	2.17e-01	9.34e-03
Signaling by MAPK mutants	6	8.49e-01	8.77e-01	0.13100	-9.75e-03	-1.30e-01	9.67e-01	5.80e-01
Interleukin-27 signaling	11	7.18e-01	7.76e-01	0.13000	-1.24e-02	1.30e-01	9.43e-01	4.57e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	4.89e-01	5.84e-01	0.13000	1.15e-01	-6.06e-02	3.73e-01	6.39e-01
Carnitine shuttle	12	6.44e-01	7.20e-01	0.13000	1.07e-01	-7.39e-02	5.22e-01	6.58e-01
FOXO-mediated transcription of cell cycle genes	14	7.58e-01	8.05e-01	0.13000	1.08e-01	7.18e-02	4.84e-01	6.42e-01
Class I MHC mediated antigen processing & presentation	343	1.66e-04	8.01e-04	0.12900	-1.28e-01	-1.62e-02	4.40e-05	6.07e-01
Arachidonate metabolism	42	2.43e-01	3.47e-01	0.12900	-4.39e-02	1.22e-01	6.23e-01	1.72e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	6.38e-01	7.16e-01	0.12900	9.16e-02	9.04e-02	4.37e-01	4.44e-01
Deactivation of the beta-catenin transactivating complex	36	4.79e-01	5.74e-01	0.12900	1.15e-01	5.80e-02	2.33e-01	5.47e-01
Activation of kainate receptors upon glutamate binding	25	5.49e-01	6.39e-01	0.12800	2.58e-02	1.26e-01	8.23e-01	2.77e-01
Signaling by Non-Receptor Tyrosine Kinases	47	1.92e-01	2.89e-01	0.12800	-6.43e-02	1.11e-01	4.46e-01	1.89e-01
Signaling by PTK6	47	1.92e-01	2.89e-01	0.12800	-6.43e-02	1.11e-01	4.46e-01	1.89e-01
Synthesis of PG	8	7.49e-01	7.98e-01	0.12800	7.93e-02	-1.01e-01	6.98e-01	6.22e-01
Diseases of metabolism	198	1.11e-02	3.13e-02	0.12700	-1.23e-01	-3.17e-02	2.75e-03	4.42e-01
FOXO-mediated transcription	57	3.10e-01	4.18e-01	0.12700	4.97e-02	1.17e-01	5.16e-01	1.28e-01
SLC15A4:TASL-dependent IRF5 activation	6	8.94e-01	9.12e-01	0.12600	-7.12e-02	-1.04e-01	7.63e-01	6.58e-01
Diseases of signal transduction by growth factor receptors and second messengers	399	2.94e-05	1.71e-04	0.12600	-8.95e-06	1.26e-01	1.00e+00	1.53e-05
LDL clearance	18	5.37e-01	6.29e-01	0.12500	-9.34e-02	8.31e-02	4.93e-01	5.42e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	8.38e-01	8.69e-01	0.12400	1.24e-01	3.71e-03	5.70e-01	9.86e-01
Nuclear signaling by ERBB4	24	4.56e-01	5.52e-01	0.12300	-6.40e-02	1.05e-01	5.87e-01	3.71e-01
Interferon Signaling	237	1.56e-02	4.09e-02	0.12300	-1.01e-01	-7.00e-02	7.19e-03	6.34e-02
Regulation of PLK1 Activity at G2/M Transition	87	8.68e-02	1.58e-01	0.12300	-1.21e-01	2.13e-02	5.05e-02	7.31e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	6.15e-01	6.96e-01	0.12300	4.11e-02	-1.16e-01	7.76e-01	4.23e-01
Regulation of TP53 Activity through Acetylation	29	3.92e-01	4.92e-01	0.12300	1.05e-01	-6.28e-02	3.26e-01	5.58e-01
Nuclear Events (kinase and transcription factor activation)	54	3.76e-01	4.78e-01	0.12200	1.07e-01	6.01e-02	1.75e-01	4.45e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	6.90e-01	7.56e-01	0.12200	-1.11e-01	5.01e-02	5.04e-01	7.64e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	78	2.62e-01	3.66e-01	0.12200	9.88e-02	7.14e-02	1.32e-01	2.76e-01
ECM proteoglycans	45	3.32e-01	4.34e-01	0.12100	-7.84e-04	1.21e-01	9.93e-01	1.61e-01
PIP3 activates AKT signaling	232	1.14e-03	4.50e-03	0.12100	-4.15e-02	1.13e-01	2.76e-01	2.93e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	6.60e-01	7.31e-01	0.12100	-7.54e-02	9.41e-02	6.38e-01	5.57e-01
Loss of Nlp from mitotic centrosomes	69	1.39e-01	2.29e-01	0.12000	-1.15e-01	3.57e-02	9.91e-02	6.08e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	1.39e-01	2.29e-01	0.12000	-1.15e-01	3.57e-02	9.91e-02	6.08e-01
Signaling by NOTCH1	66	3.00e-01	4.10e-01	0.12000	4.93e-02	1.09e-01	4.89e-01	1.24e-01
Intraflagellar transport	47	4.35e-01	5.33e-01	0.12000	-5.49e-02	-1.07e-01	5.15e-01	2.06e-01
Post-translational protein modification	1231	4.26e-14	7.80e-13	0.12000	-1.18e-01	1.92e-02	2.88e-12	2.59e-01
Inositol phosphate metabolism	42	5.04e-01	5.96e-01	0.12000	9.04e-02	7.85e-02	3.11e-01	3.79e-01
Intracellular signaling by second messengers	264	1.34e-03	5.13e-03	0.11800	-1.47e-02	1.18e-01	6.81e-01	1.01e-03
Toll Like Receptor 2 (TLR2) Cascade	109	1.37e-01	2.26e-01	0.11800	4.35e-02	1.10e-01	4.33e-01	4.70e-02
Toll Like Receptor TLR1:TLR2 Cascade	109	1.37e-01	2.26e-01	0.11800	4.35e-02	1.10e-01	4.33e-01	4.70e-02
STING mediated induction of host immune responses	15	7.44e-01	7.96e-01	0.11800	-3.03e-02	-1.14e-01	8.39e-01	4.43e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	6.89e-01	7.56e-01	0.11800	-9.64e-02	-6.80e-02	4.24e-01	5.72e-01
Notch-HLH transcription pathway	28	6.41e-01	7.18e-01	0.11800	9.06e-02	7.54e-02	4.07e-01	4.90e-01
Zinc transporters	12	6.92e-01	7.57e-01	0.11800	-7.84e-02	8.79e-02	6.38e-01	5.98e-01
Deubiquitination	225	1.16e-03	4.54e-03	0.11800	-7.08e-02	9.40e-02	6.74e-02	1.51e-02
Centrosome maturation	81	1.79e-01	2.74e-01	0.11800	-1.17e-01	-1.44e-02	6.94e-02	8.23e-01
Recruitment of mitotic centrosome proteins and complexes	81	1.79e-01	2.74e-01	0.11800	-1.17e-01	-1.44e-02	6.94e-02	8.23e-01
Collagen biosynthesis and modifying enzymes	45	3.85e-01	4.86e-01	0.11700	1.37e-02	1.16e-01	8.74e-01	1.77e-01
Organelle biogenesis and maintenance	277	1.28e-02	3.49e-02	0.11700	-9.58e-02	-6.70e-02	6.09e-03	5.49e-02
Inflammasomes	21	7.14e-01	7.73e-01	0.11700	6.35e-02	9.80e-02	6.15e-01	4.37e-01
FasL/ CD95L signaling	5	8.62e-01	8.86e-01	0.11700	6.76e-02	-9.49e-02	7.93e-01	7.13e-01
Signaling by FGFR4	32	4.36e-01	5.35e-01	0.11600	-2.83e-02	1.12e-01	7.82e-01	2.71e-01
G beta:gamma signalling through PI3Kgamma	22	5.92e-01	6.77e-01	0.11600	-1.08e-02	1.15e-01	9.30e-01	3.49e-01
Effects of PIP2 hydrolysis	24	5.41e-01	6.33e-01	0.11600	1.13e-01	-2.55e-02	3.38e-01	8.29e-01
Nitric oxide stimulates guanylate cyclase	15	6.52e-01	7.27e-01	0.11600	-5.54e-02	1.02e-01	7.10e-01	4.96e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	1.67e-01	2.59e-01	0.11500	4.99e-02	1.04e-01	3.70e-01	6.19e-02
Toll Like Receptor TLR6:TLR2 Cascade	108	1.67e-01	2.59e-01	0.11500	4.99e-02	1.04e-01	3.70e-01	6.19e-02
InlB-mediated entry of Listeria monocytogenes into host cell	12	7.05e-01	7.65e-01	0.11500	-9.10e-02	7.06e-02	5.85e-01	6.72e-01
Biosynthesis of DHA-derived SPMs	13	8.08e-01	8.42e-01	0.11500	5.07e-02	1.03e-01	7.52e-01	5.20e-01
TBC/RABGAPs	45	3.77e-01	4.79e-01	0.11400	-2.28e-04	1.14e-01	9.98e-01	1.87e-01
Transport of small molecules	548	3.78e-07	2.89e-06	0.11400	-5.79e-02	9.77e-02	2.06e-02	9.28e-05
HDR through MMEJ (alt-NHEJ)	12	7.71e-01	8.15e-01	0.11300	8.68e-04	-1.13e-01	9.96e-01	4.96e-01
Regulation of TP53 Activity	151	1.03e-01	1.81e-01	0.11200	-9.65e-02	-5.76e-02	4.06e-02	2.22e-01
Phospholipase C-mediated cascade; FGFR4	6	9.01e-01	9.17e-01	0.11200	1.07e-01	3.09e-02	6.49e-01	8.96e-01
MITF-M-regulated melanocyte development	110	9.10e-02	1.63e-01	0.11200	-8.86e-03	1.11e-01	8.73e-01	4.39e-02
Immune System	1824	1.84e-19	5.60e-18	0.11200	-4.54e-02	1.02e-01	1.32e-03	5.69e-13
Vitamin B5 (pantothenate) metabolism	20	5.82e-01	6.67e-01	0.11100	-6.50e-02	9.03e-02	6.15e-01	4.85e-01
Cargo trafficking to the periciliary membrane	47	4.92e-01	5.85e-01	0.11100	-5.13e-02	-9.83e-02	5.43e-01	2.43e-01
cGMP effects	12	7.31e-01	7.86e-01	0.11100	-9.71e-02	5.31e-02	5.60e-01	7.50e-01
Metabolism of water-soluble vitamins and cofactors	114	1.56e-01	2.46e-01	0.11100	-1.05e-01	-3.59e-02	5.37e-02	5.08e-01
Signaling by TGF-beta Receptor Complex	90	1.48e-01	2.37e-01	0.11100	-7.39e-03	1.10e-01	9.04e-01	7.06e-02
Carboxyterminal post-translational modifications of tubulin	33	4.21e-01	5.20e-01	0.11000	-5.71e-02	9.45e-02	5.70e-01	3.48e-01
TNFR1-induced NF-kappa-B signaling pathway	32	4.96e-01	5.90e-01	0.11000	1.10e-01	-1.30e-02	2.83e-01	8.99e-01
RAF-independent MAPK1/3 activation	21	7.14e-01	7.73e-01	0.10900	3.52e-02	1.03e-01	7.80e-01	4.12e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	7.02e-02	1.34e-01	0.10900	-2.69e-02	1.05e-01	6.15e-01	4.92e-02
MyD88-independent TLR4 cascade	108	2.28e-01	3.31e-01	0.10900	6.27e-02	8.87e-02	2.61e-01	1.11e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	2.28e-01	3.31e-01	0.10900	6.27e-02	8.87e-02	2.61e-01	1.11e-01
Cell recruitment (pro-inflammatory response)	25	5.77e-01	6.62e-01	0.10800	-1.07e-01	2.02e-02	3.56e-01	8.61e-01
Purinergic signaling in leishmaniasis infection	25	5.77e-01	6.62e-01	0.10800	-1.07e-01	2.02e-02	3.56e-01	8.61e-01
FRS-mediated FGFR1 signaling	15	8.05e-01	8.40e-01	0.10800	4.93e-02	9.64e-02	7.41e-01	5.18e-01
Costimulation by the CD28 family	74	1.48e-01	2.37e-01	0.10800	7.30e-02	-8.00e-02	2.78e-01	2.34e-01
Adaptive Immune System	763	8.12e-09	8.00e-08	0.10800	-9.17e-02	5.75e-02	1.64e-05	6.95e-03
RHOH GTPase cycle	33	6.16e-01	6.97e-01	0.10800	4.62e-02	9.78e-02	6.46e-01	3.31e-01
Oncogenic MAPK signaling	75	1.52e-01	2.42e-01	0.10800	-9.08e-02	5.83e-02	1.74e-01	3.83e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	8.56e-01	8.81e-01	0.10800	-9.42e-02	-5.25e-02	5.89e-01	7.63e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	6.89e-01	7.56e-01	0.10800	-1.14e-02	1.07e-01	9.33e-01	4.31e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	6.89e-01	7.56e-01	0.10800	-1.14e-02	1.07e-01	9.33e-01	4.31e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	4.97e-01	5.90e-01	0.10800	-9.12e-02	5.70e-02	4.04e-01	6.02e-01
Toll Like Receptor 3 (TLR3) Cascade	104	2.39e-01	3.42e-01	0.10700	5.35e-02	9.28e-02	3.46e-01	1.02e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	7.04e-01	7.65e-01	0.10700	-6.47e-02	8.52e-02	6.75e-01	5.81e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	7.04e-01	7.65e-01	0.10700	-6.47e-02	8.52e-02	6.75e-01	5.81e-01
Signaling by Retinoic Acid	29	6.17e-01	6.98e-01	0.10700	-2.17e-02	-1.05e-01	8.40e-01	3.29e-01
Amino acid transport across the plasma membrane	24	6.96e-01	7.59e-01	0.10700	-1.00e-01	-3.68e-02	3.95e-01	7.55e-01
Small interfering RNA (siRNA) biogenesis	9	7.99e-01	8.36e-01	0.10600	7.33e-02	-7.69e-02	7.03e-01	6.89e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	5.43e-01	6.34e-01	0.10600	-6.28e-02	8.49e-02	5.87e-01	4.62e-01
Lewis blood group biosynthesis	13	7.32e-01	7.87e-01	0.10500	5.67e-02	-8.87e-02	7.23e-01	5.80e-01
Developmental Biology	904	8.37e-10	9.13e-09	0.10500	-8.68e-02	5.95e-02	9.71e-06	2.42e-03
Sensory perception of taste	22	6.39e-01	7.17e-01	0.10500	1.04e-01	-1.71e-02	4.00e-01	8.90e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	17	6.80e-01	7.49e-01	0.10500	-9.58e-02	4.22e-02	4.94e-01	7.63e-01
Death Receptor Signaling	145	1.57e-01	2.48e-01	0.10400	5.71e-02	8.74e-02	2.35e-01	6.92e-02
Interleukin-17 signaling	68	2.36e-01	3.40e-01	0.10400	-2.77e-02	1.01e-01	6.93e-01	1.51e-01
MAP kinase activation	63	2.48e-01	3.52e-01	0.10300	-4.19e-02	9.46e-02	5.66e-01	1.94e-01
Trafficking and processing of endosomal TLR	13	7.92e-01	8.31e-01	0.10200	-3.13e-03	1.02e-01	9.84e-01	5.23e-01
Cardiogenesis	13	7.43e-01	7.95e-01	0.10200	6.40e-02	-7.91e-02	6.90e-01	6.21e-01
Nuclear Envelope Breakdown	53	5.37e-01	6.29e-01	0.10100	-7.71e-02	-6.60e-02	3.31e-01	4.06e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	5.41e-01	6.32e-01	0.10100	3.09e-02	9.66e-02	7.23e-01	2.67e-01
Norepinephrine Neurotransmitter Release Cycle	14	8.16e-01	8.48e-01	0.10100	9.83e-02	2.46e-02	5.24e-01	8.74e-01
p75 NTR receptor-mediated signalling	89	1.62e-01	2.55e-01	0.10100	-3.51e-02	9.43e-02	5.68e-01	1.24e-01
Fertilization	12	7.67e-01	8.11e-01	0.10000	-6.24e-02	7.86e-02	7.08e-01	6.37e-01
Transcriptional activation of mitochondrial biogenesis	52	5.16e-01	6.08e-01	0.09940	9.18e-02	3.82e-02	2.52e-01	6.34e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	8.84e-01	9.03e-01	0.09870	-9.00e-03	-9.83e-02	9.65e-01	6.30e-01
RUNX2 regulates osteoblast differentiation	16	8.23e-01	8.56e-01	0.09870	8.87e-02	4.31e-02	5.39e-01	7.65e-01
Metabolism of carbohydrates	236	1.04e-02	2.95e-02	0.09790	-9.10e-02	3.60e-02	1.60e-02	3.41e-01
Defects in cobalamin (B12) metabolism	13	8.69e-01	8.92e-01	0.09740	-7.37e-02	-6.36e-02	6.45e-01	6.91e-01
LTC4-CYSLTR mediated IL4 production	5	9.45e-01	9.53e-01	0.09730	-5.19e-02	-8.23e-02	8.41e-01	7.50e-01
Killing mechanisms	9	8.39e-01	8.69e-01	0.09650	-8.70e-02	4.19e-02	6.51e-01	8.28e-01
WNT5:FZD7-mediated leishmania damping	9	8.39e-01	8.69e-01	0.09650	-8.70e-02	4.19e-02	6.51e-01	8.28e-01
Phospholipid metabolism	182	1.40e-01	2.29e-01	0.09650	7.94e-02	5.48e-02	6.46e-02	2.03e-01
Regulation of TNFR1 signaling	47	5.96e-01	6.79e-01	0.09650	8.14e-02	5.17e-02	3.34e-01	5.40e-01
Oncogene Induced Senescence	33	6.63e-01	7.34e-01	0.09600	3.01e-02	9.11e-02	7.65e-01	3.65e-01
C-type lectin receptors (CLRs)	116	9.76e-02	1.73e-01	0.09550	-6.99e-02	6.50e-02	1.93e-01	2.27e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	7.32e-01	7.86e-01	0.09430	-8.77e-02	-3.46e-02	4.30e-01	7.55e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	7.42e-01	7.94e-01	0.09400	9.38e-02	5.46e-03	4.57e-01	9.65e-01
Visual phototransduction	58	3.48e-01	4.50e-01	0.09400	-3.74e-02	8.62e-02	6.22e-01	2.56e-01
Transcriptional Regulation by VENTX	38	4.85e-01	5.80e-01	0.09380	5.19e-02	-7.81e-02	5.80e-01	4.05e-01
Glycosphingolipid metabolism	46	4.78e-01	5.74e-01	0.09340	-9.22e-02	1.48e-02	2.79e-01	8.62e-01
TNFs bind their physiological receptors	24	7.64e-01	8.10e-01	0.09330	8.62e-02	3.56e-02	4.65e-01	7.63e-01
Metal ion SLC transporters	19	7.57e-01	8.05e-01	0.09320	-1.32e-03	9.32e-02	9.92e-01	4.82e-01
Cytokine Signaling in Immune system	660	5.76e-05	3.12e-04	0.09220	-1.04e-02	9.16e-02	6.50e-01	5.98e-05
Inactivation of CSF3 (G-CSF) signaling	24	6.91e-01	7.57e-01	0.09200	-1.23e-02	9.12e-02	9.17e-01	4.39e-01
CD28 co-stimulation	33	5.95e-01	6.78e-01	0.09200	9.06e-02	-1.60e-02	3.68e-01	8.73e-01
Vitamin B2 (riboflavin) metabolism	6	9.43e-01	9.52e-01	0.09180	-7.32e-02	-5.54e-02	7.56e-01	8.14e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	8.12e-01	8.46e-01	0.09170	-9.14e-02	8.42e-03	5.54e-01	9.56e-01
Mitochondrial unfolded protein response (UPRmt)	17	8.15e-01	8.48e-01	0.09160	-2.07e-02	-8.92e-02	8.82e-01	5.24e-01
MyD88 cascade initiated on plasma membrane	95	3.14e-01	4.20e-01	0.09160	1.85e-02	8.97e-02	7.55e-01	1.31e-01
Toll Like Receptor 10 (TLR10) Cascade	95	3.14e-01	4.20e-01	0.09160	1.85e-02	8.97e-02	7.55e-01	1.31e-01
Toll Like Receptor 5 (TLR5) Cascade	95	3.14e-01	4.20e-01	0.09160	1.85e-02	8.97e-02	7.55e-01	1.31e-01
Nicotinamide salvaging	15	7.65e-01	8.11e-01	0.09030	-7.33e-02	5.28e-02	6.23e-01	7.23e-01
RAF activation	32	5.66e-01	6.53e-01	0.09000	-5.52e-02	7.11e-02	5.89e-01	4.86e-01
Sensory processing of sound by outer hair cells of the cochlea	40	6.95e-01	7.59e-01	0.08960	6.03e-02	6.63e-02	5.09e-01	4.68e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	6.09e-01	6.91e-01	0.08850	6.36e-02	6.16e-02	4.10e-01	4.26e-01
SUMOylation of immune response proteins	12	8.95e-01	9.12e-01	0.08780	4.41e-02	7.59e-02	7.92e-01	6.49e-01
Listeria monocytogenes entry into host cells	17	8.12e-01	8.46e-01	0.08660	-8.65e-02	-2.99e-03	5.37e-01	9.83e-01
Cilium Assembly	186	2.06e-01	3.08e-01	0.08590	-5.03e-02	-6.96e-02	2.37e-01	1.02e-01
MyD88 dependent cascade initiated on endosome	101	4.22e-01	5.21e-01	0.08580	4.92e-02	7.03e-02	3.93e-01	2.22e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	107	3.22e-01	4.24e-01	0.08540	-1.71e-02	-8.36e-02	7.60e-01	1.35e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	5.28e-01	6.20e-01	0.08490	-7.15e-02	4.59e-02	4.28e-01	6.11e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	6.99e-01	7.62e-01	0.08410	-1.62e-02	8.25e-02	8.84e-01	4.58e-01
Acyl chain remodelling of PE	19	8.39e-01	8.69e-01	0.08360	-7.86e-02	-2.84e-02	5.53e-01	8.30e-01
Signaling by Activin	13	8.43e-01	8.72e-01	0.08350	1.70e-02	-8.18e-02	9.16e-01	6.10e-01
SARS-CoV-1 activates/modulates innate immune responses	40	7.29e-01	7.85e-01	0.08330	-6.40e-02	-5.33e-02	4.84e-01	5.59e-01
Endogenous sterols	17	8.54e-01	8.80e-01	0.08330	7.85e-02	2.77e-02	5.75e-01	8.43e-01
Signaling by FGFR1	42	7.15e-01	7.73e-01	0.08320	4.98e-02	6.67e-02	5.77e-01	4.55e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	5.46e-01	6.36e-01	0.08280	-2.69e-02	-7.83e-02	7.06e-01	2.71e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	4.35e-01	5.34e-01	0.08240	4.66e-02	6.81e-02	4.10e-01	2.28e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	4.64e-01	5.60e-01	0.08200	5.09e-02	6.42e-02	3.79e-01	2.67e-01
Beta-oxidation of very long chain fatty acids	11	8.50e-01	8.77e-01	0.08170	-5.41e-02	6.12e-02	7.56e-01	7.25e-01
IFNG signaling activates MAPKs	8	9.04e-01	9.19e-01	0.08140	-1.77e-02	7.94e-02	9.31e-01	6.97e-01
NOD1/2 Signaling Pathway	36	7.02e-01	7.63e-01	0.08100	8.00e-02	1.29e-02	4.06e-01	8.93e-01
Eicosanoid ligand-binding receptors	13	8.49e-01	8.77e-01	0.08090	-7.85e-02	1.98e-02	6.24e-01	9.02e-01
Formation of definitive endoderm	8	9.07e-01	9.21e-01	0.08090	-1.47e-02	7.96e-02	9.43e-01	6.97e-01
Signaling by Hippo	18	8.66e-01	8.90e-01	0.08090	7.10e-02	3.87e-02	6.02e-01	7.76e-01
Heparan sulfate/heparin (HS-GAG) metabolism	39	7.49e-01	7.98e-01	0.08080	-5.94e-02	-5.48e-02	5.21e-01	5.54e-01
Respiratory Syncytial Virus Infection Pathway	97	4.30e-01	5.29e-01	0.08000	-7.63e-02	-2.41e-02	1.94e-01	6.82e-01
Negative regulation of MAPK pathway	42	5.65e-01	6.52e-01	0.07930	-4.34e-02	6.63e-02	6.26e-01	4.57e-01
Ephrin signaling	17	8.29e-01	8.61e-01	0.07850	7.81e-02	-8.21e-03	5.77e-01	9.53e-01
Glucose metabolism	76	3.84e-01	4.85e-01	0.07740	-6.89e-02	3.52e-02	2.99e-01	5.95e-01
Phase 3 - rapid repolarisation	6	9.25e-01	9.38e-01	0.07690	6.22e-02	-4.51e-02	7.92e-01	8.48e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	5.61e-01	6.50e-01	0.07550	-7.55e-02	-5.17e-04	3.08e-01	9.94e-01
TNF signaling	56	6.87e-01	7.55e-01	0.07550	6.34e-02	4.10e-02	4.12e-01	5.95e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	8.78e-01	8.98e-01	0.07550	-3.07e-02	-6.90e-02	8.22e-01	6.13e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	8.73e-01	8.94e-01	0.07540	6.27e-02	-4.19e-02	7.19e-01	8.10e-01
Signaling by FGFR	73	5.96e-01	6.79e-01	0.07460	-6.84e-02	-2.96e-02	3.12e-01	6.62e-01
Metabolism of lipids	631	5.88e-04	2.53e-03	0.07440	-4.46e-02	5.96e-02	5.61e-02	1.06e-02
A tetrasaccharide linker sequence is required for GAG synthesis	16	8.24e-01	8.56e-01	0.07430	-4.41e-02	5.98e-02	7.60e-01	6.79e-01
RIPK1-mediated regulated necrosis	31	8.01e-01	8.37e-01	0.07350	6.90e-02	2.53e-02	5.06e-01	8.07e-01
Regulation of necroptotic cell death	31	8.01e-01	8.37e-01	0.07350	6.90e-02	2.53e-02	5.06e-01	8.07e-01
Toll Like Receptor 9 (TLR9) Cascade	108	5.15e-01	6.08e-01	0.07330	4.51e-02	5.77e-02	4.18e-01	3.00e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	9.49e-01	9.57e-01	0.07310	-3.16e-03	-7.30e-02	9.89e-01	7.57e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	8.70e-01	8.92e-01	0.07290	5.33e-03	-7.27e-02	9.71e-01	6.26e-01
Interferon gamma signaling	87	4.98e-01	5.90e-01	0.07140	-6.50e-03	-7.11e-02	9.17e-01	2.52e-01
SLC transporter disorders	75	5.57e-01	6.47e-01	0.07080	-7.42e-03	-7.04e-02	9.11e-01	2.92e-01
Alpha-protein kinase 1 signaling pathway	11	8.89e-01	9.07e-01	0.07000	-4.23e-02	5.57e-02	8.08e-01	7.49e-01
Aspartate and asparagine metabolism	8	9.25e-01	9.38e-01	0.06990	2.08e-02	-6.67e-02	9.19e-01	7.44e-01
Maturation of nucleoprotein 9694631	15	8.75e-01	8.96e-01	0.06990	-9.45e-03	6.92e-02	9.49e-01	6.42e-01
Post NMDA receptor activation events	60	5.84e-01	6.69e-01	0.06940	-1.26e-02	6.82e-02	8.66e-01	3.61e-01
Glycolysis	68	5.17e-01	6.09e-01	0.06940	-6.52e-02	2.37e-02	3.53e-01	7.36e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	9.35e-01	9.45e-01	0.06870	-6.67e-02	-1.62e-02	7.15e-01	9.29e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	8.60e-01	8.84e-01	0.06870	6.87e-02	-5.88e-04	6.04e-01	9.96e-01
SLC-mediated transmembrane transport	171	2.57e-01	3.63e-01	0.06800	-3.58e-03	6.79e-02	9.36e-01	1.26e-01
Activation of NMDA receptors and postsynaptic events	70	6.10e-01	6.92e-01	0.06790	8.68e-03	6.73e-02	9.00e-01	3.30e-01
RSV-host interactions	76	6.39e-01	7.17e-01	0.06730	-2.48e-02	-6.26e-02	7.08e-01	3.46e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	35	7.25e-01	7.83e-01	0.06540	5.60e-02	-3.38e-02	5.66e-01	7.30e-01
Nicotinate metabolism	26	8.79e-01	8.99e-01	0.06520	3.73e-02	5.35e-02	7.42e-01	6.37e-01
Regulation of endogenous retroelements	92	4.49e-01	5.47e-01	0.06460	-5.83e-02	2.79e-02	3.34e-01	6.44e-01
Regulation of PTEN gene transcription	59	7.29e-01	7.85e-01	0.06320	-5.98e-02	-2.05e-02	4.27e-01	7.86e-01
Chromatin modifying enzymes	213	3.86e-01	4.86e-01	0.06290	4.84e-02	4.02e-02	2.24e-01	3.13e-01
Chromatin organization	213	3.86e-01	4.86e-01	0.06290	4.84e-02	4.02e-02	2.24e-01	3.13e-01
TP53 Regulates Transcription of Cell Death Genes	42	7.70e-01	8.15e-01	0.06170	6.16e-02	2.22e-03	4.89e-01	9.80e-01
Maturation of nucleoprotein 9683610	11	9.16e-01	9.29e-01	0.06080	-5.14e-02	3.25e-02	7.68e-01	8.52e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	6.54e-01	7.27e-01	0.06030	-4.34e-02	4.18e-02	5.85e-01	5.99e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	6.54e-01	7.27e-01	0.06030	-4.34e-02	4.18e-02	5.85e-01	5.99e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	6.54e-01	7.27e-01	0.06030	-4.34e-02	4.18e-02	5.85e-01	5.99e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	6.54e-01	7.27e-01	0.06030	-4.34e-02	4.18e-02	5.85e-01	5.99e-01
Signaling by NOTCH1 in Cancer	53	6.54e-01	7.27e-01	0.06030	-4.34e-02	4.18e-02	5.85e-01	5.99e-01
TICAM1-dependent activation of IRF3/IRF7	13	9.10e-01	9.24e-01	0.05760	3.51e-02	-4.57e-02	8.26e-01	7.75e-01
Chondroitin sulfate/dermatan sulfate metabolism	37	7.77e-01	8.18e-01	0.05660	-2.72e-02	4.97e-02	7.75e-01	6.01e-01
RND1 GTPase cycle	36	8.52e-01	8.78e-01	0.05620	1.40e-02	5.45e-02	8.84e-01	5.72e-01
Cell death signalling via NRAGE, NRIF and NADE	69	6.62e-01	7.33e-01	0.05550	-1.45e-02	5.35e-02	8.35e-01	4.42e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	8.96e-01	9.12e-01	0.05520	2.76e-02	4.78e-02	7.93e-01	6.50e-01
Anchoring of the basal body to the plasma membrane	97	6.91e-01	7.57e-01	0.05510	-5.00e-02	-2.34e-02	3.95e-01	6.91e-01
VEGFR2 mediated vascular permeability	25	8.71e-01	8.93e-01	0.05410	-1.07e-02	5.30e-02	9.26e-01	6.46e-01
Intra-Golgi traffic	43	7.76e-01	8.17e-01	0.05210	-2.93e-02	4.32e-02	7.40e-01	6.24e-01
Signaling by NOTCH2	33	8.91e-01	9.09e-01	0.05160	1.81e-02	4.83e-02	8.57e-01	6.31e-01
Regulated Necrosis	55	7.72e-01	8.15e-01	0.05140	-5.12e-02	5.06e-03	5.12e-01	9.48e-01
The canonical retinoid cycle in rods (twilight vision)	9	9.53e-01	9.60e-01	0.05100	-2.05e-02	4.67e-02	9.15e-01	8.08e-01
Gene expression (Transcription)	1391	1.55e-02	4.05e-02	0.05090	-4.54e-02	-2.31e-02	4.61e-03	1.49e-01
Evasion by RSV of host interferon responses	20	9.02e-01	9.17e-01	0.04920	4.27e-02	-2.44e-02	7.41e-01	8.50e-01
IKK complex recruitment mediated by RIP1	23	8.99e-01	9.15e-01	0.04910	-1.17e-02	4.77e-02	9.23e-01	6.92e-01
Retrograde transport at the Trans-Golgi-Network	49	8.80e-01	8.99e-01	0.04800	-3.34e-02	-3.45e-02	6.86e-01	6.76e-01
Diseases of glycosylation	104	6.25e-01	7.05e-01	0.04620	-4.03e-02	2.24e-02	4.77e-01	6.93e-01
Activated point mutants of FGFR2	7	9.73e-01	9.78e-01	0.04560	4.46e-02	-9.54e-03	8.38e-01	9.65e-01
Cellular hexose transport	14	9.54e-01	9.61e-01	0.04550	2.39e-03	4.54e-02	9.88e-01	7.69e-01
Glycerophospholipid biosynthesis	104	6.95e-01	7.59e-01	0.04490	-4.48e-02	2.71e-03	4.30e-01	9.62e-01
Phospholipase C-mediated cascade; FGFR3	5	9.89e-01	9.92e-01	0.04450	3.45e-02	2.81e-02	8.94e-01	9.13e-01
Signaling by FGFR in disease	52	8.24e-01	8.56e-01	0.04250	-3.91e-02	1.68e-02	6.26e-01	8.34e-01
G-protein beta:gamma signalling	29	9.43e-01	9.52e-01	0.04020	1.77e-02	3.61e-02	8.69e-01	7.37e-01
RNA Polymerase II Transcription	1185	8.80e-02	1.59e-01	0.03920	-3.80e-02	-9.74e-03	2.78e-02	5.73e-01
GABA synthesis, release, reuptake and degradation	12	9.62e-01	9.68e-01	0.03880	3.29e-02	-2.06e-02	8.44e-01	9.02e-01
TAK1-dependent IKK and NF-kappa-B activation	43	9.31e-01	9.42e-01	0.03820	2.88e-02	2.51e-02	7.44e-01	7.76e-01
ERBB2 Regulates Cell Motility	10	9.76e-01	9.81e-01	0.03810	3.81e-02	-9.47e-05	8.35e-01	1.00e+00
Epigenetic regulation of gene expression	263	4.84e-01	5.80e-01	0.03790	-3.67e-02	9.69e-03	3.06e-01	7.87e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	9.32e-01	9.43e-01	0.03710	1.02e-03	3.71e-02	9.92e-01	7.21e-01
Phase I - Functionalization of compounds	62	8.67e-01	8.91e-01	0.03580	-3.56e-02	3.98e-03	6.28e-01	9.57e-01
SHC-mediated cascade:FGFR1	13	9.83e-01	9.87e-01	0.03460	2.49e-02	2.40e-02	8.77e-01	8.81e-01
SUMOylation of transcription cofactors	44	9.29e-01	9.41e-01	0.03430	-3.33e-02	-8.11e-03	7.02e-01	9.26e-01
Signaling by ERBB2	44	9.31e-01	9.42e-01	0.02810	-2.59e-02	1.09e-02	7.66e-01	9.01e-01
Passive transport by Aquaporins	6	9.91e-01	9.94e-01	0.02640	1.40e-02	-2.24e-02	9.53e-01	9.24e-01
EPH-ephrin mediated repulsion of cells	42	9.43e-01	9.52e-01	0.02620	-9.33e-03	2.45e-02	9.17e-01	7.83e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	9.93e-01	9.95e-01	0.02280	7.13e-03	-2.17e-02	9.74e-01	9.21e-01
Generic Transcription Pathway	1067	4.60e-01	5.56e-01	0.02260	-2.23e-02	-3.72e-03	2.19e-01	8.37e-01
SUMOylation	167	8.60e-01	8.84e-01	0.02150	6.29e-03	-2.05e-02	8.88e-01	6.47e-01
FGFR4 ligand binding and activation	5	9.96e-01	9.97e-01	0.02070	-2.03e-02	4.36e-03	9.37e-01	9.87e-01
Cobalamin (Cbl) metabolism	7	9.96e-01	9.97e-01	0.01950	1.92e-02	3.49e-03	9.30e-01	9.87e-01
SUMO E3 ligases SUMOylate target proteins	161	9.21e-01	9.34e-01	0.01590	1.49e-02	-5.59e-03	7.44e-01	9.03e-01
The NLRP3 inflammasome	16	9.92e-01	9.95e-01	0.01470	-1.21e-02	8.39e-03	9.33e-01	9.54e-01
Synthesis of PA	31	9.86e-01	9.90e-01	0.01440	8.97e-03	-1.12e-02	9.31e-01	9.14e-01
Calcineurin activates NFAT	9	9.97e-01	9.97e-01	0.01270	1.05e-02	-7.23e-03	9.57e-01	9.70e-01
ERK/MAPK targets	22	1.00e+00	1.00e+00	0.00198	-1.77e-03	8.83e-04	9.89e-01	9.94e-01

---

Detailed Gene set reports

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	100
pMANOVA	2.98e-59
p.adjustMANOVA	5.2e-57
s.dist	1.08
s.crp_eos_adj	-0.84
s.crp_pod1_adj	-0.685
p.crp_eos_adj	5.84e-48
p.crp_pod1_adj	1.9e-32

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
EIF3E	-9518	-9950
EIF3L	-8996	-10527
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
FAU	-8641	-7814
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	88
pMANOVA	4.37e-52
p.adjustMANOVA	5.59e-50
s.dist	1.08
s.crp_eos_adj	-0.84
s.crp_pod1_adj	-0.683
p.crp_eos_adj	1.98e-42
p.crp_pod1_adj	1.52e-28

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
EEF1A1	-9363	-10205
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EEF1A1	-9363	-10205
EEF2	-6935	-9743
FAU	-8641	-7814
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	93
pMANOVA	1.15e-53
p.adjustMANOVA	1.7e-51
s.dist	1.07
s.crp_eos_adj	-0.832
s.crp_pod1_adj	-0.671
p.crp_eos_adj	6.61e-44
p.crp_pod1_adj	4.36e-29

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
EEF1A1	-9363	-10205
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EEF1A1	-9363	-10205
EEF1A1P5	-8517	-9332
EEF1A2	-104	4408
EEF1B2	-9265	-7992
EEF1D	-7206	-6102
EEF1G	-8899	-6666
EEF2	-6935	-9743
FAU	-8641	-7814
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	88
pMANOVA	7.35e-50
p.adjustMANOVA	7.43e-48
s.dist	1.06
s.crp_eos_adj	-0.829
s.crp_pod1_adj	-0.657
p.crp_eos_adj	2.53e-41
p.crp_pod1_adj	1.44e-26

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157
RPL15	-9548	-8811

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
DNAJC3	3501	9936
FAU	-8641	-7814
GRSF1	-9194	-6314
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

metric	value
setSize	36
pMANOVA	2.16e-20
p.adjustMANOVA	6.79e-19
s.dist	1.05
s.crp_eos_adj	-0.816
s.crp_pod1_adj	-0.656
p.crp_eos_adj	2.2e-17
p.crp_pod1_adj	9.46e-12

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
EEF1A1	-9363	-10205
RPS3A	-9753	-9470
RPS7	-9854	-9266
RPS20	-9683	-9170
RPS3	-9183	-9224
RPS11	-9013	-8801
RPS25	-9662	-8182
RPS24	-9564	-8137
RPS10	-8944	-8544
RPS27A	-8766	-8662
RPS6	-9487	-7609
RPS8	-9588	-7508
RPS15A	-9526	-7188
FAU	-8641	-7814
RPS23	-9400	-7096
RPS27L	-8425	-7848
RPS4Y1	-6859	-9435
RPS14	-7795	-8270

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EEF1A1	-9363	-10205
FAU	-8641	-7814
HNRNPA1	-8701	-7179
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	110
pMANOVA	9.95e-61
p.adjustMANOVA	2.12e-58
s.dist	1.04
s.crp_eos_adj	-0.824
s.crp_pod1_adj	-0.642
p.crp_eos_adj	1.25e-50
p.crp_pod1_adj	2.41e-31

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
EIF3E	-9518	-9950
EIF3L	-8996	-10527
PABPC1	-9253	-10199
RPL4	-9770	-9599
RPL7	-9845	-9516
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4G1	743	9134
EIF4H	-8420	-1990
FAU	-8641	-7814
PABPC1	-9253	-10199
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	92
pMANOVA	2.17e-50
p.adjustMANOVA	2.61e-48
s.dist	1.04
s.crp_eos_adj	-0.802
s.crp_pod1_adj	-0.666
p.crp_eos_adj	1.72e-40
p.crp_pod1_adj	2.22e-28

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157
RPL15	-9548	-8811

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EEFSEC	-8178	-5918
FAU	-8641	-7814
PSTK	-115	-6949
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SARS1	-6668	-6251
SECISBP2	-1708	-9292
SEPHS2	1552	4044
SEPSECS	2131	-8986
UBA52	-9162	-8694

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	92
pMANOVA	3.46e-50
p.adjustMANOVA	3.87e-48
s.dist	1.04
s.crp_eos_adj	-0.807
s.crp_pod1_adj	-0.654
p.crp_eos_adj	5.21e-41
p.crp_pod1_adj	1.89e-27

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157
RPL15	-9548	-8811

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
APEH	-7874	-5912
ETF1	-2242	1854
FAU	-8641	-7814
GSPT1	-2605	2477
GSPT2	-1594	-4161
N6AMT1	5049	-9555
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
TRMT112	-8876	-6800
UBA52	-9162	-8694

---

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

metric	value
setSize	51
pMANOVA	6.46e-28
p.adjustMANOVA	2.7e-26
s.dist	1.03
s.crp_eos_adj	-0.81
s.crp_pod1_adj	-0.643
p.crp_eos_adj	1.33e-23
p.crp_pod1_adj	1.88e-15

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF3E	-9518	-9950
EIF3L	-8996	-10527
RPS3A	-9753	-9470
RPS7	-9854	-9266
RPS20	-9683	-9170
RPS3	-9183	-9224
EIF3K	-9427	-8837
EIF3H	-9566	-8422
RPS11	-9013	-8801
RPS25	-9662	-8182
RPS24	-9564	-8137
EIF3G	-8638	-8878
RPS10	-8944	-8544
RPS27A	-8766	-8662
EIF3D	-8750	-8611
RPS6	-9487	-7609
RPS8	-9588	-7508

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
FAU	-8641	-7814
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	111
pMANOVA	4.31e-60
p.adjustMANOVA	8.28e-58
s.dist	1.03
s.crp_eos_adj	-0.819
s.crp_pod1_adj	-0.63
p.crp_eos_adj	1.55e-50
p.crp_pod1_adj	1.75e-30

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
EIF3E	-9518	-9950
EIF3L	-8996	-10527
RPL4	-9770	-9599
RPL7	-9845	-9516
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4G1	743	9134
EIF4H	-8420	-1990
EIF5	-8214	-1818
EIF5B	-4033	-1176
FAU	-8641	-7814
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

metric	value
setSize	118
pMANOVA	5.15e-63
p.adjustMANOVA	1.24e-60
s.dist	1.03
s.crp_eos_adj	-0.814
s.crp_pod1_adj	-0.626
p.crp_eos_adj	6.42e-53
p.crp_pod1_adj	6.44e-32

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF4EBP1	-9866	-9883
RPL29	-9677	-9865
EIF3E	-9518	-9950
EIF3L	-8996	-10527
PABPC1	-9253	-10199
RPL4	-9770	-9599
RPL7	-9845	-9516
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2B1	-8483	-10134
EIF2B2	-8727	2545
EIF2B3	-5780	-4309
EIF2B4	-5228	-6172
EIF2B5	-2997	-5226
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4EBP1	-9866	-9883
EIF4G1	743	9134
EIF4H	-8420	-1990
EIF5	-8214	-1818
EIF5B	-4033	-1176
FAU	-8641	-7814
PABPC1	-9253	-10199
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

metric	value
setSize	118
pMANOVA	5.15e-63
p.adjustMANOVA	1.24e-60
s.dist	1.03
s.crp_eos_adj	-0.814
s.crp_pod1_adj	-0.626
p.crp_eos_adj	6.42e-53
p.crp_pod1_adj	6.44e-32

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF4EBP1	-9866	-9883
RPL29	-9677	-9865
EIF3E	-9518	-9950
EIF3L	-8996	-10527
PABPC1	-9253	-10199
RPL4	-9770	-9599
RPL7	-9845	-9516
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2B1	-8483	-10134
EIF2B2	-8727	2545
EIF2B3	-5780	-4309
EIF2B4	-5228	-6172
EIF2B5	-2997	-5226
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4EBP1	-9866	-9883
EIF4G1	743	9134
EIF4H	-8420	-1990
EIF5	-8214	-1818
EIF5B	-4033	-1176
FAU	-8641	-7814
PABPC1	-9253	-10199
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	94
pMANOVA	1.07e-49
p.adjustMANOVA	1.02e-47
s.dist	1.02
s.crp_eos_adj	-0.8
s.crp_pod1_adj	-0.636
p.crp_eos_adj	4.32e-41
p.crp_pod1_adj	1.29e-26

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
PABPC1	-9253	-10199
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF4G1	743	9134
ETF1	-2242	1854
FAU	-8641	-7814
GSPT1	-2605	2477
GSPT2	-1594	-4161
NCBP1	-1831	-6289
NCBP2	-7633	-10381
PABPC1	-9253	-10199
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
UBA52	-9162	-8694
UPF1	-2139	-1560

---

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

metric	value
setSize	59
pMANOVA	6.62e-30
p.adjustMANOVA	3.03e-28
s.dist	0.993
s.crp_eos_adj	-0.793
s.crp_pod1_adj	-0.597
p.crp_eos_adj	5.06e-26
p.crp_pod1_adj	2.03e-15

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF4EBP1	-9866	-9883
EIF3E	-9518	-9950
EIF3L	-8996	-10527
PABPC1	-9253	-10199
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPS7	-9854	-9266
RPS20	-9683	-9170
RPS3	-9183	-9224
EIF3K	-9427	-8837
EIF3H	-9566	-8422
RPS11	-9013	-8801
RPS25	-9662	-8182
RPS24	-9564	-8137
EIF3G	-8638	-8878
RPS10	-8944	-8544
RPS27A	-8766	-8662

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4EBP1	-9866	-9883
EIF4G1	743	9134
EIF4H	-8420	-1990
FAU	-8641	-7814
PABPC1	-9253	-10199
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584

---

---

Translation initiation complex formation

Translation initiation complex formation

metric	value
setSize	58
pMANOVA	4.28e-29
p.adjustMANOVA	1.87e-27
s.dist	0.987
s.crp_eos_adj	-0.79
s.crp_pod1_adj	-0.592
p.crp_eos_adj	2.04e-25
p.crp_pod1_adj	6.16e-15

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF3E	-9518	-9950
EIF3L	-8996	-10527
PABPC1	-9253	-10199
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPS7	-9854	-9266
RPS20	-9683	-9170
RPS3	-9183	-9224
EIF3K	-9427	-8837
EIF3H	-9566	-8422
RPS11	-9013	-8801
RPS25	-9662	-8182
RPS24	-9564	-8137
EIF3G	-8638	-8878
RPS10	-8944	-8544
RPS27A	-8766	-8662
EIF3D	-8750	-8611

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4G1	743	9134
EIF4H	-8420	-1990
FAU	-8641	-7814
PABPC1	-9253	-10199
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584

---

---

Mitochondrial translation initiation

Mitochondrial translation initiation

metric	value
setSize	90
pMANOVA	7.91e-45
p.adjustMANOVA	6.33e-43
s.dist	0.984
s.crp_eos_adj	-0.804
s.crp_pod1_adj	-0.568
p.crp_eos_adj	8.28e-40
p.crp_pod1_adj	1.22e-20

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MRPS21	-9987	-10091
MRPL32	-9559	-10473
MRPL45	-9378	-10324
MTIF2	-9438	-9774
MRPL37	-10079	-9129
DAP3	-9688	-9341
MRPL34	-9474	-9431
MRPL15	-10103	-8812
MRPS7	-9698	-9038
MRPS18B	-9160	-9529
MRPL57	-9556	-8949
MRPL20	-9263	-8979
MRPS27	-9180	-8862
OXA1L	-8575	-9315
MRPL40	-9599	-8107
MRPL48	-9321	-8079
MRPS14	-7713	-9722
MRPL55	-7768	-9430
MRPL46	-9282	-7883
MRPL27	-8663	-8445

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AURKAIP1	-6882	-6364
CHCHD1	-9221	-4571
DAP3	-9688	-9341
ERAL1	-7660	-7598
GADD45GIP1	-9091	-2300
MRPL1	-6607	-5926
MRPL10	-6934	-9988
MRPL11	-9387	-7707
MRPL12	-9368	-5514
MRPL13	-7466	-4486
MRPL14	-8200	-8848
MRPL15	-10103	-8812
MRPL16	-9115	-7639
MRPL17	-9576	-7422
MRPL18	-8431	2181
MRPL19	-6471	-4150
MRPL2	-5297	-9425
MRPL20	-9263	-8979
MRPL21	-7800	-3925
MRPL22	-7128	-5720
MRPL23	-8061	-978
MRPL24	-8980	-5422
MRPL27	-8663	-8445
MRPL28	-5958	449
MRPL3	-10042	-7131
MRPL30	-5885	-6708
MRPL32	-9559	-10473
MRPL33	-7065	-3831
MRPL34	-9474	-9431
MRPL35	-5325	-7025
MRPL36	-8969	-1863
MRPL37	-10079	-9129
MRPL38	-6743	-3903
MRPL39	-5697	-9041
MRPL4	-8215	-6355
MRPL40	-9599	-8107
MRPL41	-4874	-6973
MRPL42	-3769	-6325
MRPL43	-7319	-7991
MRPL44	-9153	-5491
MRPL45	-9378	-10324
MRPL46	-9282	-7883
MRPL47	-8176	-3296
MRPL48	-9321	-8079
MRPL49	-8286	-6724
MRPL50	-1465	-5532
MRPL51	-9785	-2978
MRPL52	-9030	-567
MRPL53	-8793	-2826
MRPL54	-8945	-7443
MRPL55	-7768	-9430
MRPL57	-9556	-8949
MRPL58	-8696	-4390
MRPL9	-8529	-7499
MRPS10	-5872	-4095
MRPS11	-8809	3330
MRPS14	-7713	-9722
MRPS15	-9790	-3777
MRPS16	-9974	-6716
MRPS17	-8937	-7155
MRPS18A	-8134	-5933
MRPS18B	-9160	-9529
MRPS18C	-9142	-5864
MRPS2	-8085	-8920
MRPS21	-9987	-10091
MRPS22	-9758	-7073
MRPS23	-8322	-3326
MRPS24	-8160	-6713
MRPS25	-6125	-10803
MRPS26	-8455	-6299
MRPS27	-9180	-8862
MRPS28	-9928	-5307
MRPS30	-6998	-8601
MRPS31	-5362	367
MRPS33	-6724	-6249
MRPS34	-7527	-5560
MRPS35	-8721	-6077
MRPS36	-6510	-2159
MRPS5	-8695	-2555
MRPS6	3401	-7896
MRPS7	-9698	-9038
MRPS9	-7025	-8440
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MTFMT	-7846	-9248
MTIF2	-9438	-9774
MTIF3	-8670	-3182
OXA1L	-8575	-9315
PTCD3	-8256	-7826
RPS12	-7926	-7498

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	111
pMANOVA	7.34e-55
p.adjustMANOVA	1.18e-52
s.dist	0.981
s.crp_eos_adj	-0.803
s.crp_pod1_adj	-0.564
p.crp_eos_adj	1.4e-48
p.crp_pod1_adj	8.83e-25

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
SEC11A	-9829	-10422
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
SSR2	-9532	-9873
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
DDOST	-8725	-1145
FAU	-8641	-7814
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPN1	-8959	4348
RPN2	-8879	7344
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SEC11A	-9829	-10422
SEC11C	-8765	-7161
SEC61A1	-7822	-637
SEC61A2	4438	-6589
SEC61B	-7726	-3113
SEC61G	-8163	-3435
SPCS1	-9645	-6339
SPCS2	-6776	3534
SPCS3	-2916	1183
SRP14	-9025	1489
SRP19	-4065	2342
SRP54	-960	6845
SRP68	-6960	-3124
SRP72	-8770	-4400
SRP9	-8524	-7569
SRPRA	1944	2018
SRPRB	-9436	-6609
SSR1	-1032	-3969
SSR2	-9532	-9873
SSR3	-9477	-4921
SSR4	-9073	-4015
TRAM1	-6972	1128
UBA52	-9162	-8694

---

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

metric	value
setSize	58
pMANOVA	1.26e-28
p.adjustMANOVA	5.39e-27
s.dist	0.977
s.crp_eos_adj	-0.788
s.crp_pod1_adj	-0.578
p.crp_eos_adj	2.58e-25
p.crp_pod1_adj	2.55e-14

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF3E	-9518	-9950
EIF3L	-8996	-10527
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPS7	-9854	-9266
RPS20	-9683	-9170
RPS3	-9183	-9224
EIF3K	-9427	-8837
EIF3H	-9566	-8422
RPS11	-9013	-8801
RPS25	-9662	-8182
RPS24	-9564	-8137
EIF3G	-8638	-8878
RPS10	-8944	-8544
RPS27A	-8766	-8662
EIF3D	-8750	-8611
RPS6	-9487	-7609

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
EIF1AX	-6165	-4207
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4G1	743	9134
EIF4H	-8420	-1990
EIF5	-8214	-1818
FAU	-8641	-7814
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584

---

---

Mitochondrial translation elongation

Mitochondrial translation elongation

metric	value
setSize	90
pMANOVA	2.13e-43
p.adjustMANOVA	1.46e-41
s.dist	0.968
s.crp_eos_adj	-0.79
s.crp_pod1_adj	-0.559
p.crp_eos_adj	1.48e-38
p.crp_pod1_adj	4.76e-20

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MRPS21	-9987	-10091
MRPL32	-9559	-10473
MRPL45	-9378	-10324
MRPL37	-10079	-9129
DAP3	-9688	-9341
MRPL34	-9474	-9431
MRPL15	-10103	-8812
MRPS7	-9698	-9038
MRPS18B	-9160	-9529
MRPL57	-9556	-8949
MRPL20	-9263	-8979
MRPS27	-9180	-8862
OXA1L	-8575	-9315
TSFM	-9407	-8328
MRPL40	-9599	-8107
MRPL48	-9321	-8079
MRPS14	-7713	-9722
MRPL55	-7768	-9430
MRPL46	-9282	-7883
MRPL27	-8663	-8445

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AURKAIP1	-6882	-6364
CHCHD1	-9221	-4571
DAP3	-9688	-9341
ERAL1	-7660	-7598
GADD45GIP1	-9091	-2300
GFM1	4319	-1715
MRPL1	-6607	-5926
MRPL10	-6934	-9988
MRPL11	-9387	-7707
MRPL12	-9368	-5514
MRPL13	-7466	-4486
MRPL14	-8200	-8848
MRPL15	-10103	-8812
MRPL16	-9115	-7639
MRPL17	-9576	-7422
MRPL18	-8431	2181
MRPL19	-6471	-4150
MRPL2	-5297	-9425
MRPL20	-9263	-8979
MRPL21	-7800	-3925
MRPL22	-7128	-5720
MRPL23	-8061	-978
MRPL24	-8980	-5422
MRPL27	-8663	-8445
MRPL28	-5958	449
MRPL3	-10042	-7131
MRPL30	-5885	-6708
MRPL32	-9559	-10473
MRPL33	-7065	-3831
MRPL34	-9474	-9431
MRPL35	-5325	-7025
MRPL36	-8969	-1863
MRPL37	-10079	-9129
MRPL38	-6743	-3903
MRPL39	-5697	-9041
MRPL4	-8215	-6355
MRPL40	-9599	-8107
MRPL41	-4874	-6973
MRPL42	-3769	-6325
MRPL43	-7319	-7991
MRPL44	-9153	-5491
MRPL45	-9378	-10324
MRPL46	-9282	-7883
MRPL47	-8176	-3296
MRPL48	-9321	-8079
MRPL49	-8286	-6724
MRPL50	-1465	-5532
MRPL51	-9785	-2978
MRPL52	-9030	-567
MRPL53	-8793	-2826
MRPL54	-8945	-7443
MRPL55	-7768	-9430
MRPL57	-9556	-8949
MRPL58	-8696	-4390
MRPL9	-8529	-7499
MRPS10	-5872	-4095
MRPS11	-8809	3330
MRPS14	-7713	-9722
MRPS15	-9790	-3777
MRPS16	-9974	-6716
MRPS17	-8937	-7155
MRPS18A	-8134	-5933
MRPS18B	-9160	-9529
MRPS18C	-9142	-5864
MRPS2	-8085	-8920
MRPS21	-9987	-10091
MRPS22	-9758	-7073
MRPS23	-8322	-3326
MRPS24	-8160	-6713
MRPS25	-6125	-10803
MRPS26	-8455	-6299
MRPS27	-9180	-8862
MRPS28	-9928	-5307
MRPS30	-6998	-8601
MRPS31	-5362	367
MRPS33	-6724	-6249
MRPS34	-7527	-5560
MRPS35	-8721	-6077
MRPS36	-6510	-2159
MRPS5	-8695	-2555
MRPS6	3401	-7896
MRPS7	-9698	-9038
MRPS9	-7025	-8440
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
OXA1L	-8575	-9315
PTCD3	-8256	-7826
RPS12	-7926	-7498
TSFM	-9407	-8328
TUFM	-8306	-3795

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	100
pMANOVA	6.09e-47
p.adjustMANOVA	5.08e-45
s.dist	0.961
s.crp_eos_adj	-0.762
s.crp_pod1_adj	-0.586
p.crp_eos_adj	1.06e-39
p.crp_pod1_adj	3.63e-24

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157
RPL15	-9548	-8811

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ASNS	8429	-1423
ATF2	-289	230
ATF3	7975	9012
ATF4	-9669	-7572
CEBPB	7245	8012
CEBPG	-7494	-5046
DDIT3	-7581	937
EIF2AK4	-9069	-7567
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
FAU	-8641	-7814
GCN1	5589	3509
IMPACT	-6300	-6441
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
TRIB3	-2862	4527
UBA52	-9162	-8694

---

---

Mitochondrial translation termination

Mitochondrial translation termination

metric	value
setSize	90
pMANOVA	3.18e-42
p.adjustMANOVA	2.03e-40
s.dist	0.954
s.crp_eos_adj	-0.78
s.crp_pod1_adj	-0.55
p.crp_eos_adj	1.34e-37
p.crp_pod1_adj	1.84e-19

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MRPS21	-9987	-10091
MRPL32	-9559	-10473
MRPL45	-9378	-10324
MRPL37	-10079	-9129
DAP3	-9688	-9341
MRPL34	-9474	-9431
MRPL15	-10103	-8812
MRPS7	-9698	-9038
MRPS18B	-9160	-9529
MRRF	-8385	-10344
MRPL57	-9556	-8949
MRPL20	-9263	-8979
MRPS27	-9180	-8862
OXA1L	-8575	-9315
MRPL40	-9599	-8107
MRPL48	-9321	-8079
MRPS14	-7713	-9722
MRPL55	-7768	-9430
MRPL46	-9282	-7883
MRPL27	-8663	-8445

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AURKAIP1	-6882	-6364
CHCHD1	-9221	-4571
DAP3	-9688	-9341
ERAL1	-7660	-7598
GADD45GIP1	-9091	-2300
GFM2	-149	391
MRPL1	-6607	-5926
MRPL10	-6934	-9988
MRPL11	-9387	-7707
MRPL12	-9368	-5514
MRPL13	-7466	-4486
MRPL14	-8200	-8848
MRPL15	-10103	-8812
MRPL16	-9115	-7639
MRPL17	-9576	-7422
MRPL18	-8431	2181
MRPL19	-6471	-4150
MRPL2	-5297	-9425
MRPL20	-9263	-8979
MRPL21	-7800	-3925
MRPL22	-7128	-5720
MRPL23	-8061	-978
MRPL24	-8980	-5422
MRPL27	-8663	-8445
MRPL28	-5958	449
MRPL3	-10042	-7131
MRPL30	-5885	-6708
MRPL32	-9559	-10473
MRPL33	-7065	-3831
MRPL34	-9474	-9431
MRPL35	-5325	-7025
MRPL36	-8969	-1863
MRPL37	-10079	-9129
MRPL38	-6743	-3903
MRPL39	-5697	-9041
MRPL4	-8215	-6355
MRPL40	-9599	-8107
MRPL41	-4874	-6973
MRPL42	-3769	-6325
MRPL43	-7319	-7991
MRPL44	-9153	-5491
MRPL45	-9378	-10324
MRPL46	-9282	-7883
MRPL47	-8176	-3296
MRPL48	-9321	-8079
MRPL49	-8286	-6724
MRPL50	-1465	-5532
MRPL51	-9785	-2978
MRPL52	-9030	-567
MRPL53	-8793	-2826
MRPL54	-8945	-7443
MRPL55	-7768	-9430
MRPL57	-9556	-8949
MRPL58	-8696	-4390
MRPL9	-8529	-7499
MRPS10	-5872	-4095
MRPS11	-8809	3330
MRPS14	-7713	-9722
MRPS15	-9790	-3777
MRPS16	-9974	-6716
MRPS17	-8937	-7155
MRPS18A	-8134	-5933
MRPS18B	-9160	-9529
MRPS18C	-9142	-5864
MRPS2	-8085	-8920
MRPS21	-9987	-10091
MRPS22	-9758	-7073
MRPS23	-8322	-3326
MRPS24	-8160	-6713
MRPS25	-6125	-10803
MRPS26	-8455	-6299
MRPS27	-9180	-8862
MRPS28	-9928	-5307
MRPS30	-6998	-8601
MRPS31	-5362	367
MRPS33	-6724	-6249
MRPS34	-7527	-5560
MRPS35	-8721	-6077
MRPS36	-6510	-2159
MRPS5	-8695	-2555
MRPS6	3401	-7896
MRPS7	-9698	-9038
MRPS9	-7025	-8440
MRRF	-8385	-10344
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MTRF1L	4887	4578
OXA1L	-8575	-9315
PTCD3	-8256	-7826
RPS12	-7926	-7498

---

---

Mitochondrial translation

Mitochondrial translation

metric	value
setSize	96
pMANOVA	2.25e-44
p.adjustMANOVA	1.73e-42
s.dist	0.948
s.crp_eos_adj	-0.773
s.crp_pod1_adj	-0.549
p.crp_eos_adj	2.75e-39
p.crp_pod1_adj	1.26e-20

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MRPS21	-9987	-10091
MRPL32	-9559	-10473
MRPL45	-9378	-10324
MTIF2	-9438	-9774
MRPL37	-10079	-9129
DAP3	-9688	-9341
MRPL34	-9474	-9431
MRPL15	-10103	-8812
MRPS7	-9698	-9038
MRPS18B	-9160	-9529
MRRF	-8385	-10344
MRPL57	-9556	-8949
MRPL20	-9263	-8979
MRPS27	-9180	-8862
OXA1L	-8575	-9315
TSFM	-9407	-8328
MRPL40	-9599	-8107
MRPL48	-9321	-8079
MRPS14	-7713	-9722
MRPL55	-7768	-9430

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AURKAIP1	-6882	-6364
CHCHD1	-9221	-4571
DAP3	-9688	-9341
ERAL1	-7660	-7598
GADD45GIP1	-9091	-2300
GFM1	4319	-1715
GFM2	-149	391
MRPL1	-6607	-5926
MRPL10	-6934	-9988
MRPL11	-9387	-7707
MRPL12	-9368	-5514
MRPL13	-7466	-4486
MRPL14	-8200	-8848
MRPL15	-10103	-8812
MRPL16	-9115	-7639
MRPL17	-9576	-7422
MRPL18	-8431	2181
MRPL19	-6471	-4150
MRPL2	-5297	-9425
MRPL20	-9263	-8979
MRPL21	-7800	-3925
MRPL22	-7128	-5720
MRPL23	-8061	-978
MRPL24	-8980	-5422
MRPL27	-8663	-8445
MRPL28	-5958	449
MRPL3	-10042	-7131
MRPL30	-5885	-6708
MRPL32	-9559	-10473
MRPL33	-7065	-3831
MRPL34	-9474	-9431
MRPL35	-5325	-7025
MRPL36	-8969	-1863
MRPL37	-10079	-9129
MRPL38	-6743	-3903
MRPL39	-5697	-9041
MRPL4	-8215	-6355
MRPL40	-9599	-8107
MRPL41	-4874	-6973
MRPL42	-3769	-6325
MRPL43	-7319	-7991
MRPL44	-9153	-5491
MRPL45	-9378	-10324
MRPL46	-9282	-7883
MRPL47	-8176	-3296
MRPL48	-9321	-8079
MRPL49	-8286	-6724
MRPL50	-1465	-5532
MRPL51	-9785	-2978
MRPL52	-9030	-567
MRPL53	-8793	-2826
MRPL54	-8945	-7443
MRPL55	-7768	-9430
MRPL57	-9556	-8949
MRPL58	-8696	-4390
MRPL9	-8529	-7499
MRPS10	-5872	-4095
MRPS11	-8809	3330
MRPS14	-7713	-9722
MRPS15	-9790	-3777
MRPS16	-9974	-6716
MRPS17	-8937	-7155
MRPS18A	-8134	-5933
MRPS18B	-9160	-9529
MRPS18C	-9142	-5864
MRPS2	-8085	-8920
MRPS21	-9987	-10091
MRPS22	-9758	-7073
MRPS23	-8322	-3326
MRPS24	-8160	-6713
MRPS25	-6125	-10803
MRPS26	-8455	-6299
MRPS27	-9180	-8862
MRPS28	-9928	-5307
MRPS30	-6998	-8601
MRPS31	-5362	367
MRPS33	-6724	-6249
MRPS34	-7527	-5560
MRPS35	-8721	-6077
MRPS36	-6510	-2159
MRPS5	-8695	-2555
MRPS6	3401	-7896
MRPS7	-9698	-9038
MRPS9	-7025	-8440
MRRF	-8385	-10344
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MTFMT	-7846	-9248
MTIF2	-9438	-9774
MTIF3	-8670	-3182
MTRF1L	4887	4578
OXA1L	-8575	-9315
PTCD3	-8256	-7826
RPS12	-7926	-7498
TSFM	-9407	-8328
TUFM	-8306	-3795

---

---

Formation of xylulose-5-phosphate

Formation of xylulose-5-phosphate

metric	value
setSize	5
pMANOVA	0.00662
p.adjustMANOVA	0.02
s.dist	0.937
s.crp_eos_adj	-0.6
s.crp_pod1_adj	-0.72
p.crp_eos_adj	0.0202
p.crp_pod1_adj	0.0053

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
XYLB	-8970	-10083
CRYL1	-8450	-9097
AKR1A1	-8865	-7190
DCXR	-9322	-6119

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AKR1A1	-8865	-7190
CRYL1	-8450	-9097
DCXR	-9322	-6119
SORD	5946	-7070
XYLB	-8970	-10083

---

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

metric	value
setSize	49
pMANOVA	3.8e-21
p.adjustMANOVA	1.26e-19
s.dist	0.912
s.crp_eos_adj	-0.727
s.crp_pod1_adj	-0.551
p.crp_eos_adj	1.27e-18
p.crp_pod1_adj	2.47e-11

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPS3A	-9753	-9470
RPS7	-9854	-9266
RPS20	-9683	-9170
RPS3	-9183	-9224
RPS11	-9013	-8801
RPS25	-9662	-8182
RPS24	-9564	-8137
RPS10	-8944	-8544
RPS27A	-8766	-8662
SNRPE	-9481	-7901
RPS6	-9487	-7609
RPS8	-9588	-7508
RPS15A	-9526	-7188
FAU	-8641	-7814
RPS23	-9400	-7096
RPS27L	-8425	-7848
RPS4Y1	-6859	-9435
RPS14	-7795	-8270

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
DDX20	-3869	-107
FAU	-8641	-7814
GEMIN2	-3602	-8279
GEMIN4	-4607	-4908
GEMIN5	-2348	2552
GEMIN6	-8077	-355
GEMIN7	-1956	-9463
GEMIN8	2813	-2344
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SMN1	-3749	-4187
SNRPB	-8582	-3659
SNRPD1	-9454	-2813
SNRPD2	-8188	-4547
SNRPD3	-4950	-5644
SNRPE	-9481	-7901
SNRPF	-4873	-2975
SNRPG	-7283	-2245

---

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

metric	value
setSize	20
pMANOVA	3.72e-10
p.adjustMANOVA	4.26e-09
s.dist	0.902
s.crp_eos_adj	-0.85
s.crp_pod1_adj	-0.3
p.crp_eos_adj	4.51e-11
p.crp_pod1_adj	0.02

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
ATP5MC1	-9617	-8992
DMAC2L	-7741	-10822
ATP5MC2	-8981	-8486
ATP5F1A	-9119	-8293
ATP5MG	-9762	-7364
ATP5PO	-9533	-7277
ATP5F1D	-6994	-7712
ATP5F1C	-9676	-5520
ATP5F1B	-9083	-4871
ATP5MJ	-8098	-5161
ATP5PB	-9398	-4229
ATP5MK	-10028	-1878
ATP5PD	-9347	-1722
ATP5MC3	-7798	-1714
ATP5F1E	-9661	-898

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ATP5F1A	-9119	-8293
ATP5F1B	-9083	-4871
ATP5F1C	-9676	-5520
ATP5F1D	-6994	-7712
ATP5F1E	-9661	-898
ATP5MC1	-9617	-8992
ATP5MC2	-8981	-8486
ATP5MC3	-7798	-1714
ATP5ME	-5210	1885
ATP5MF	-8458	4322
ATP5MG	-9762	-7364
ATP5MJ	-8098	-5161
ATP5MK	-10028	-1878
ATP5PB	-9398	-4229
ATP5PD	-9347	-1722
ATP5PF	-9332	1685
ATP5PO	-9533	-7277
DMAC2L	-7741	-10822
MT-ATP6	-8590	3553
MT-ATP8	-4983	3929

---

---

Selenoamino acid metabolism

Selenoamino acid metabolism

metric	value
setSize	115
pMANOVA	2.3e-47
p.adjustMANOVA	2.11e-45
s.dist	0.901
s.crp_eos_adj	-0.71
s.crp_pod1_adj	-0.555
p.crp_eos_adj	1.16e-39
p.crp_pod1_adj	7.23e-25

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
AHCY	-9923	-8551
AIMP1	-8351	-10143
RPS3	-9183	-9224

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AHCY	-9923	-8551
AIMP1	-8351	-10143
AIMP2	-9715	-8568
CBS	-1699	2365
CTH	7923	5101
DARS1	-9001	-5147
EEF1E1	-8592	1195
EEFSEC	-8178	-5918
EPRS1	-5604	1997
FAU	-8641	-7814
GNMT	7752	-6653
GSR	-7900	9983
HNMT	-674	-9328
IARS1	2736	-4146
INMT	6372	3737
KARS1	-9319	-4806
LARS1	-3365	-4357
MARS1	3434	-2790
NNMT	-9386	3790
PAPSS1	-9094	7778
PAPSS2	-5176	5977
PSTK	-115	-6949
QARS1	-7391	-10599
RARS1	-7594	-9189
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SARS1	-6668	-6251
SCLY	9980	373
SECISBP2	-1708	-9292
SEPHS2	1552	4044
SEPSECS	2131	-8986
TXNRD1	2035	8071
UBA52	-9162	-8694

---

---

Complex III assembly

Complex III assembly

metric	value
setSize	23
pMANOVA	3.07e-10
p.adjustMANOVA	3.53e-09
s.dist	0.896
s.crp_eos_adj	-0.758
s.crp_pod1_adj	-0.477
p.crp_eos_adj	3.03e-10
p.crp_pod1_adj	7.53e-05

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
FXN	-9896	-10748
UQCRC2	-9821	-9151
HSCB	-9678	-8529
UQCRH	-10071	-7641
ISCU	-7845	-9538
UQCC1	-7493	-9941
UQCRB	-9609	-6504
LYRM4	-9511	-6424
UQCC2	-7599	-7947
CYC1	-8624	-6395
UQCRFS1	-8421	-5647
HSPA9	-5678	-8365
UQCRQ	-9197	-4469
UQCR11	-9118	-4403
UQCC3	-7208	-5181
BCS1L	-6057	-5750
UQCR10	-7751	-2959
LYRM7	-2389	-9314
NFS1	-2040	-245

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
BCS1L	-6057	-5750
CYC1	-8624	-6395
FXN	-9896	-10748
HSCB	-9678	-8529
HSPA9	-5678	-8365
ISCU	-7845	-9538
LETM1	-4469	4125
LYRM4	-9511	-6424
LYRM7	-2389	-9314
MT-CYB	-7431	1487
NFS1	-2040	-245
TTC19	-6352	499
UQCC1	-7493	-9941
UQCC2	-7599	-7947
UQCC3	-7208	-5181
UQCR10	-7751	-2959
UQCR11	-9118	-4403
UQCRB	-9609	-6504
UQCRC1	-8487	228
UQCRC2	-9821	-9151
UQCRFS1	-8421	-5647
UQCRH	-10071	-7641
UQCRQ	-9197	-4469

---

---

Response to metal ions

Response to metal ions

metric	value
setSize	6
pMANOVA	3.76e-05
p.adjustMANOVA	0.000215
s.dist	0.891
s.crp_eos_adj	-0.44
s.crp_pod1_adj	0.775
p.crp_eos_adj	0.0621
p.crp_pod1_adj	0.00101

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MT1X	-9498	9071
MT1E	-8123	8697
CSRP1	-8866	5100
MT2A	-5072	8794
MT1F	-4301	5898

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
CSRP1	-8866	5100
MT1E	-8123	8697
MT1F	-4301	5898
MT1X	-9498	9071
MT2A	-5072	8794
MTF1	10419	9703

---

---

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

metric	value
setSize	5
pMANOVA	0.0108
p.adjustMANOVA	0.0307
s.dist	0.891
s.crp_eos_adj	-0.679
s.crp_pod1_adj	-0.576
p.crp_eos_adj	0.00854
p.crp_pod1_adj	0.0257

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
ECHS1	-8803	-10343
HADHA	-7929	-7170
HADH	-4768	-8384
ACADS	-8320	-3183
HADHB	-4025	-2886

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ACADS	-8320	-3183
ECHS1	-8803	-10343
HADH	-4768	-8384
HADHA	-7929	-7170
HADHB	-4025	-2886

---

---

Modulation by Mtb of host immune system

Modulation by Mtb of host immune system

metric	value
setSize	7
pMANOVA	0.000778
p.adjustMANOVA	0.00325
s.dist	0.886
s.crp_eos_adj	-0.823
s.crp_pod1_adj	-0.329
p.crp_eos_adj	0.000162
p.crp_pod1_adj	0.131

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
B2M	-9951	-9880
UBA52	-9162	-8694
RPS27A	-8766	-8662
TLR2	-7217	-3215
UBC	-9582	-1567

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
B2M	-9951	-9880
MRC1	-7925	5062
RPS27A	-8766	-8662
TLR2	-7217	-3215
UBA52	-9162	-8694
UBB	-5411	446
UBC	-9582	-1567

---

---

G2/M DNA replication checkpoint

G2/M DNA replication checkpoint

metric	value
setSize	5
pMANOVA	0.000191
p.adjustMANOVA	0.000915
s.dist	0.882
s.crp_eos_adj	-0.546
s.crp_pod1_adj	0.693
p.crp_eos_adj	0.0344
p.crp_pod1_adj	0.00728

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
CDK1	-6460	8835
CCNB1	-7416	7324
CCNB2	-8688	5283
PKMYT1	-6621	6463

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
CCNB1	-7416	7324
CCNB2	-8688	5283
CDK1	-6460	8835
PKMYT1	-6621	6463
WEE1	2359	7155

---

---

Translation

Translation

metric	value
setSize	293
pMANOVA	2.19e-116
p.adjustMANOVA	4.21e-113
s.dist	0.882
s.crp_eos_adj	-0.728
s.crp_pod1_adj	-0.496
p.crp_eos_adj	3.98e-103
p.crp_pod1_adj	1.29e-48

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EIF3M	-10040	-10551
SEC11A	-9829	-10422
MRPS21	-9987	-10091
MRPL32	-9559	-10473
RPS13	-9860	-10007
RPS4X	-9749	-10114
EIF4EBP1	-9866	-9883
MRPL45	-9378	-10324
EEF1A1	-9363	-10205
RPL29	-9677	-9865
EIF3E	-9518	-9950
EIF3L	-8996	-10527
PABPC1	-9253	-10199
SSR2	-9532	-9873
RPL4	-9770	-9599
RPL7	-9845	-9516
EIF4B	-9019	-10292
RPS3A	-9753	-9470
RPL35A	-9836	-9385
MTIF2	-9438	-9774

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AARS1	-383	6521
AARS2	1582	-8649
AIMP1	-8351	-10143
AIMP2	-9715	-8568
APEH	-7874	-5912
AURKAIP1	-6882	-6364
CARS1	-3044	9553
CARS2	8093	4864
CHCHD1	-9221	-4571
DAP3	-9688	-9341
DARS1	-9001	-5147
DARS2	-3451	196
DDOST	-8725	-1145
EARS2	-5286	-3539
EEF1A1	-9363	-10205
EEF1A1P5	-8517	-9332
EEF1A2	-104	4408
EEF1B2	-9265	-7992
EEF1D	-7206	-6102
EEF1E1	-8592	1195
EEF1G	-8899	-6666
EEF2	-6935	-9743
EIF1AX	-6165	-4207
EIF2B1	-8483	-10134
EIF2B2	-8727	2545
EIF2B3	-5780	-4309
EIF2B4	-5228	-6172
EIF2B5	-2997	-5226
EIF2S1	-4167	1129
EIF2S2	-7728	1004
EIF2S3	-8466	-8408
EIF3A	-6552	-5677
EIF3B	-8040	-7909
EIF3C	-6930	-7698
EIF3D	-8750	-8611
EIF3E	-9518	-9950
EIF3F	-6458	-8919
EIF3G	-8638	-8878
EIF3H	-9566	-8422
EIF3I	-9206	-5917
EIF3J	-8563	-6170
EIF3K	-9427	-8837
EIF3L	-8996	-10527
EIF3M	-10040	-10551
EIF4A1	-8901	-6418
EIF4A2	-5030	-6134
EIF4B	-9019	-10292
EIF4E	-4855	7723
EIF4EBP1	-9866	-9883
EIF4G1	743	9134
EIF4H	-8420	-1990
EIF5	-8214	-1818
EIF5B	-4033	-1176
EPRS1	-5604	1997
ERAL1	-7660	-7598
ETF1	-2242	1854
FARS2	-7083	-2248
FARSA	-8204	-1014
FARSB	-7614	-4733
FAU	-8641	-7814
GADD45GIP1	-9091	-2300
GARS1	-5523	6371
GFM1	4319	-1715
GFM2	-149	391
GSPT1	-2605	2477
GSPT2	-1594	-4161
HARS1	-5812	-2534
HARS2	-358	-6350
IARS1	2736	-4146
IARS2	-6043	-2910
KARS1	-9319	-4806
LARS1	-3365	-4357
LARS2	5334	1464
MARS1	3434	-2790
MARS2	-6294	882
MRPL1	-6607	-5926
MRPL10	-6934	-9988
MRPL11	-9387	-7707
MRPL12	-9368	-5514
MRPL13	-7466	-4486
MRPL14	-8200	-8848
MRPL15	-10103	-8812
MRPL16	-9115	-7639
MRPL17	-9576	-7422
MRPL18	-8431	2181
MRPL19	-6471	-4150
MRPL2	-5297	-9425
MRPL20	-9263	-8979
MRPL21	-7800	-3925
MRPL22	-7128	-5720
MRPL23	-8061	-978
MRPL24	-8980	-5422
MRPL27	-8663	-8445
MRPL28	-5958	449
MRPL3	-10042	-7131
MRPL30	-5885	-6708
MRPL32	-9559	-10473
MRPL33	-7065	-3831
MRPL34	-9474	-9431
MRPL35	-5325	-7025
MRPL36	-8969	-1863
MRPL37	-10079	-9129
MRPL38	-6743	-3903
MRPL39	-5697	-9041
MRPL4	-8215	-6355
MRPL40	-9599	-8107
MRPL41	-4874	-6973
MRPL42	-3769	-6325
MRPL43	-7319	-7991
MRPL44	-9153	-5491
MRPL45	-9378	-10324
MRPL46	-9282	-7883
MRPL47	-8176	-3296
MRPL48	-9321	-8079
MRPL49	-8286	-6724
MRPL50	-1465	-5532
MRPL51	-9785	-2978
MRPL52	-9030	-567
MRPL53	-8793	-2826
MRPL54	-8945	-7443
MRPL55	-7768	-9430
MRPL57	-9556	-8949
MRPL58	-8696	-4390
MRPL9	-8529	-7499
MRPS10	-5872	-4095
MRPS11	-8809	3330
MRPS14	-7713	-9722
MRPS15	-9790	-3777
MRPS16	-9974	-6716
MRPS17	-8937	-7155
MRPS18A	-8134	-5933
MRPS18B	-9160	-9529
MRPS18C	-9142	-5864
MRPS2	-8085	-8920
MRPS21	-9987	-10091
MRPS22	-9758	-7073
MRPS23	-8322	-3326
MRPS24	-8160	-6713
MRPS25	-6125	-10803
MRPS26	-8455	-6299
MRPS27	-9180	-8862
MRPS28	-9928	-5307
MRPS30	-6998	-8601
MRPS31	-5362	367
MRPS33	-6724	-6249
MRPS34	-7527	-5560
MRPS35	-8721	-6077
MRPS36	-6510	-2159
MRPS5	-8695	-2555
MRPS6	3401	-7896
MRPS7	-9698	-9038
MRPS9	-7025	-8440
MRRF	-8385	-10344
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MTFMT	-7846	-9248
MTIF2	-9438	-9774
MTIF3	-8670	-3182
MTRF1L	4887	4578
N6AMT1	5049	-9555
NARS1	-6983	-10784
NARS2	-257	-6564
OXA1L	-8575	-9315
PABPC1	-9253	-10199
PARS2	-1279	691
PPA1	-9121	788
PPA2	-7324	1592
PTCD3	-8256	-7826
QARS1	-7391	-10599
RARS1	-7594	-9189
RARS2	-8432	-3728
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPN1	-8959	4348
RPN2	-8879	7344
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SARS1	-6668	-6251
SARS2	-7672	-7033
SEC11A	-9829	-10422
SEC11C	-8765	-7161
SEC61A1	-7822	-637
SEC61A2	4438	-6589
SEC61B	-7726	-3113
SEC61G	-8163	-3435
SPCS1	-9645	-6339
SPCS2	-6776	3534
SPCS3	-2916	1183
SRP14	-9025	1489
SRP19	-4065	2342
SRP54	-960	6845
SRP68	-6960	-3124
SRP72	-8770	-4400
SRP9	-8524	-7569
SRPRA	1944	2018
SRPRB	-9436	-6609
SSR1	-1032	-3969
SSR2	-9532	-9873
SSR3	-9477	-4921
SSR4	-9073	-4015
TARS1	-113	7684
TARS2	-6620	-8650
TRAM1	-6972	1128
TRMT112	-8876	-6800
TSFM	-9407	-8328
TUFM	-8306	-3795
UBA52	-9162	-8694
VARS1	-4910	1805
VARS2	-4115	-3815
WARS1	9024	6314
WARS2	-8773	-10420
YARS1	799	8200
YARS2	-6900	-7319

---

---

CD163 mediating an anti-inflammatory response

CD163 mediating an anti-inflammatory response

metric	value
setSize	8
pMANOVA	4.51e-05
p.adjustMANOVA	0.000251
s.dist	0.874
s.crp_eos_adj	0.0296
s.crp_pod1_adj	0.873
p.crp_eos_adj	0.885
p.crp_pod1_adj	1.88e-05

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MAPK14	10287	10066
IL10	10133	9710
FURIN	5836	9714
MYH9	1983	8563

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ADAM17	-5731	9057
CD163	-9804	8649
FURIN	5836	9714
IL10	10133	9710
MAPK14	10287	10066
MYH9	1983	8563
PLK2	-2682	7260
RHBDF2	-4292	8305

---

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

metric	value
setSize	114
pMANOVA	4.02e-44
p.adjustMANOVA	2.86e-42
s.dist	0.874
s.crp_eos_adj	-0.686
s.crp_pod1_adj	-0.541
p.crp_eos_adj	8.2e-37
p.crp_pod1_adj	1.58e-23

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
PABPC1	-9253	-10199
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
CASC3	8370	-4159
DCP1A	-1787	-2084
EIF4A3	-4572	-1253
EIF4G1	743	9134
ETF1	-2242	1854
FAU	-8641	-7814
GSPT1	-2605	2477
GSPT2	-1594	-4161
MAGOH	-8694	-2085
MAGOHB	-7055	-463
NCBP1	-1831	-6289
NCBP2	-7633	-10381
PABPC1	-9253	-10199
PNRC2	-4802	-7561
PPP2CA	-5093	3105
PPP2R1A	-6685	-2412
PPP2R2A	-1439	298
RBM8A	-4302	-5914
RNPS1	-8141	-6922
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SMG1	6995	5815
SMG5	3187	7184
SMG6	7762	-3052
SMG7	9708	8340
SMG8	-1704	-229
SMG9	-2352	-1552
UBA52	-9162	-8694
UPF1	-2139	-1560
UPF2	4412	6583
UPF3A	-4690	-10530
UPF3B	-2215	-8530

---

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

metric	value
setSize	114
pMANOVA	4.02e-44
p.adjustMANOVA	2.86e-42
s.dist	0.874
s.crp_eos_adj	-0.686
s.crp_pod1_adj	-0.541
p.crp_eos_adj	8.2e-37
p.crp_pod1_adj	1.58e-23

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPL29	-9677	-9865
PABPC1	-9253	-10199
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
RPL6	-9660	-8959
RPL18	-9266	-9330
RPL7A	-9558	-9004
RPL12	-9557	-8935
RPS3	-9183	-9224
RPL10	-9191	-9157

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
CASC3	8370	-4159
DCP1A	-1787	-2084
EIF4A3	-4572	-1253
EIF4G1	743	9134
ETF1	-2242	1854
FAU	-8641	-7814
GSPT1	-2605	2477
GSPT2	-1594	-4161
MAGOH	-8694	-2085
MAGOHB	-7055	-463
NCBP1	-1831	-6289
NCBP2	-7633	-10381
PABPC1	-9253	-10199
PNRC2	-4802	-7561
PPP2CA	-5093	3105
PPP2R1A	-6685	-2412
PPP2R2A	-1439	298
RBM8A	-4302	-5914
RNPS1	-8141	-6922
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
SMG1	6995	5815
SMG5	3187	7184
SMG6	7762	-3052
SMG7	9708	8340
SMG8	-1704	-229
SMG9	-2352	-1552
UBA52	-9162	-8694
UPF1	-2139	-1560
UPF2	4412	6583
UPF3A	-4690	-10530
UPF3B	-2215	-8530

---

---

Regulation of NFE2L2 gene expression

Regulation of NFE2L2 gene expression

metric	value
setSize	8
pMANOVA	0.00099
p.adjustMANOVA	0.00402
s.dist	0.873
s.crp_eos_adj	0.642
s.crp_pod1_adj	0.591
p.crp_eos_adj	0.00167
p.crp_pod1_adj	0.00377

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
NOTCH1	10378	9200
CREBBP	10100	9051
EP300	9917	8035
NFKB1	10248	4845
RELA	6048	4276
MYC	2553	8798
NFE2L2	3800	3392

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
CREBBP	10100	9051
EP300	9917	8035
MAFK	4395	-92
MYC	2553	8798
NFE2L2	3800	3392
NFKB1	10248	4845
NOTCH1	10378	9200
RELA	6048	4276

---

---

Phosphate bond hydrolysis by NUDT proteins

Phosphate bond hydrolysis by NUDT proteins

metric	value
setSize	7
pMANOVA	0.00187
p.adjustMANOVA	0.00687
s.dist	0.863
s.crp_eos_adj	-0.746
s.crp_pod1_adj	-0.435
p.crp_eos_adj	0.000632
p.crp_pod1_adj	0.0465

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
NUDT15	-8396	-9966
ADPRM	-9575	-8442
NUDT1	-9066	-8717
NUDT5	-6955	-6726
NUDT18	-6616	-4292
NUDT16	-9935	-1489

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ADPRM	-9575	-8442
NUDT1	-9066	-8717
NUDT15	-8396	-9966
NUDT16	-9935	-1489
NUDT18	-6616	-4292
NUDT5	-6955	-6726
NUDT9	-1766	5349

---

---

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

metric	value
setSize	5
pMANOVA	0.0155
p.adjustMANOVA	0.0406
s.dist	0.857
s.crp_eos_adj	-0.624
s.crp_pod1_adj	-0.587
p.crp_eos_adj	0.0157
p.crp_pod1_adj	0.023

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
ECHS1	-8803	-10343
HADHA	-7929	-7170
HADH	-4768	-8384
ACADL	-5409	-3764
HADHB	-4025	-2886

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ACADL	-5409	-3764
ECHS1	-8803	-10343
HADH	-4768	-8384
HADHA	-7929	-7170
HADHB	-4025	-2886

---

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

metric	value
setSize	179
pMANOVA	2.55e-65
p.adjustMANOVA	8.16e-63
s.dist	0.851
s.crp_eos_adj	-0.671
s.crp_pod1_adj	-0.523
p.crp_eos_adj	2.52e-54
p.crp_pod1_adj	1.19e-33

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EXOSC2	-9993	-10317
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPP40	-9156	-10510
RPL29	-9677	-9865
EXOSC8	-8869	-10610
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
EXOSC5	-9057	-9963
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
UTP6	-8655	-10027
RPL6	-9660	-8959
RPL18	-9266	-9330

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
BMS1	-6502	-3025
BOP1	-6011	1839
BYSL	1430	2281
C1D	-6226	-5719
CSNK1D	3131	5516
CSNK1E	721	-4478
DCAF13	-6218	-9580
DDX21	-6537	6771
DDX47	-7576	-7898
DDX49	-8222	-6107
DDX52	3234	-2652
DHX37	-3440	2561
DIS3	2144	730
EBNA1BP2	-9465	-4028
EMG1	-8067	-1412
ERI1	800	4136
EXOSC1	-9674	-8280
EXOSC10	2965	-6672
EXOSC2	-9993	-10317
EXOSC3	-2646	-8994
EXOSC4	-2632	598
EXOSC5	-9057	-9963
EXOSC6	-534	-5466
EXOSC7	-8843	-8057
EXOSC8	-8869	-10610
EXOSC9	-6969	-9530
FAU	-8641	-7814
FBL	-8319	-7774
FCF1	-2216	5019
FTSJ3	-2197	-311
GNL3	-8545	4331
HEATR1	7131	-1250
IMP3	-8442	-9500
IMP4	-8272	-6908
ISG20L2	-4727	-6015
KRR1	-542	-1590
LAS1L	-5430	-10358
LTV1	-7049	-443
MPHOSPH10	-6310	-5552
MPHOSPH6	-7012	-396
NCL	-6277	-3103
NIP7	-4740	-1254
NOB1	-9207	-9214
NOC4L	-6978	-5122
NOL11	-6162	-7675
NOL12	-6933	-6195
NOL6	-5834	2782
NOL9	-905	-9121
NOP14	-7364	-6456
NOP56	-8767	-6212
NOP58	-6181	-6529
PDCD11	159	-5969
PELP1	3157	-2162
PES1	-8648	-6272
PNO1	-6454	-4462
PWP2	1384	2629
RBM28	-1875	-10074
RCL1	-408	9406
RIOK1	-8623	-3889
RIOK2	417	3331
RIOK3	-5906	4774
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPP14	-465	-395
RPP21	-7565	-8139
RPP25	-4754	-6262
RPP30	-3546	-10710
RPP38	-5668	-9680
RPP40	-9156	-10510
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
RRP1	-5259	-7539
RRP36	-8740	-1054
RRP7A	-6664	-9222
RRP9	-7462	-9739
SENP3	-2541	118
SNU13	-8330	-9418
TBL3	-5991	-8193
TEX10	-2552	-9295
TSR1	-8236	-10333
UBA52	-9162	-8694
UTP11	-9033	-4480
UTP14A	-9659	-3758
UTP14C	-1047	-4734
UTP15	-269	-3749
UTP18	-9606	-2496
UTP20	4281	1686
UTP25	1546	-2777
UTP3	-4291	-2168
UTP4	-9947	-8458
UTP6	-8655	-10027
WDR12	-8790	-6680
WDR18	-6435	-6183
WDR3	-3913	-7730
WDR36	-3130	-3063
WDR43	-8393	86
WDR46	-9547	-6705
WDR75	-7809	-10155
XRN2	-6639	4794

---

---

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

metric	value
setSize	6
pMANOVA	0.00249
p.adjustMANOVA	0.00887
s.dist	0.844
s.crp_eos_adj	0.219
s.crp_pod1_adj	0.815
p.crp_eos_adj	0.352
p.crp_pod1_adj	0.000546

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
H19	10213	9902
ACTB	6438	7560
CD44	5450	8638
MYC	2553	8798

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ACTB	6438	7560
CD44	5450	8638
H19	10213	9902
IGF2BP2	-3708	5126
IGF2BP3	-4629	9770
MYC	2553	8798

---

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

metric	value
setSize	189
pMANOVA	1.37e-67
p.adjustMANOVA	5.26e-65
s.dist	0.843
s.crp_eos_adj	-0.663
s.crp_pod1_adj	-0.52
p.crp_eos_adj	6.04e-56
p.crp_pod1_adj	4.69e-35

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EXOSC2	-9993	-10317
RPS13	-9860	-10007
RPS4X	-9749	-10114
RPP40	-9156	-10510
RPL29	-9677	-9865
EXOSC8	-8869	-10610
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
EXOSC5	-9057	-9963
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
UTP6	-8655	-10027
RPL6	-9660	-8959
RPL18	-9266	-9330

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
BMS1	-6502	-3025
BOP1	-6011	1839
BYSL	1430	2281
C1D	-6226	-5719
CSNK1D	3131	5516
CSNK1E	721	-4478
DCAF13	-6218	-9580
DDX21	-6537	6771
DDX47	-7576	-7898
DDX49	-8222	-6107
DDX52	3234	-2652
DHX37	-3440	2561
DIMT1	-6488	-5430
DIS3	2144	730
DKC1	-4817	-9683
EBNA1BP2	-9465	-4028
EMG1	-8067	-1412
ERI1	800	4136
EXOSC1	-9674	-8280
EXOSC10	2965	-6672
EXOSC2	-9993	-10317
EXOSC3	-2646	-8994
EXOSC4	-2632	598
EXOSC5	-9057	-9963
EXOSC6	-534	-5466
EXOSC7	-8843	-8057
EXOSC8	-8869	-10610
EXOSC9	-6969	-9530
FAU	-8641	-7814
FBL	-8319	-7774
FCF1	-2216	5019
FTSJ3	-2197	-311
GAR1	-623	-8511
GNL3	-8545	4331
HEATR1	7131	-1250
IMP3	-8442	-9500
IMP4	-8272	-6908
ISG20L2	-4727	-6015
KRR1	-542	-1590
LAS1L	-5430	-10358
LTV1	-7049	-443
MPHOSPH10	-6310	-5552
MPHOSPH6	-7012	-396
NAT10	-3320	-3960
NCL	-6277	-3103
NHP2	-8805	-6768
NIP7	-4740	-1254
NOB1	-9207	-9214
NOC4L	-6978	-5122
NOL11	-6162	-7675
NOL12	-6933	-6195
NOL6	-5834	2782
NOL9	-905	-9121
NOP10	-6233	1935
NOP14	-7364	-6456
NOP2	-3370	-1032
NOP56	-8767	-6212
NOP58	-6181	-6529
PDCD11	159	-5969
PELP1	3157	-2162
PES1	-8648	-6272
PNO1	-6454	-4462
PWP2	1384	2629
RBM28	-1875	-10074
RCL1	-408	9406
RIOK1	-8623	-3889
RIOK2	417	3331
RIOK3	-5906	4774
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPP14	-465	-395
RPP21	-7565	-8139
RPP25	-4754	-6262
RPP30	-3546	-10710
RPP38	-5668	-9680
RPP40	-9156	-10510
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
RRP1	-5259	-7539
RRP36	-8740	-1054
RRP7A	-6664	-9222
RRP9	-7462	-9739
SENP3	-2541	118
SNU13	-8330	-9418
TBL3	-5991	-8193
TEX10	-2552	-9295
THUMPD1	223	-5517
TRMT112	-8876	-6800
TSR1	-8236	-10333
TSR3	-7647	-5907
UBA52	-9162	-8694
UTP11	-9033	-4480
UTP14A	-9659	-3758
UTP14C	-1047	-4734
UTP15	-269	-3749
UTP18	-9606	-2496
UTP20	4281	1686
UTP25	1546	-2777
UTP3	-4291	-2168
UTP4	-9947	-8458
UTP6	-8655	-10027
WDR12	-8790	-6680
WDR18	-6435	-6183
WDR3	-3913	-7730
WDR36	-3130	-3063
WDR43	-8393	86
WDR46	-9547	-6705
WDR75	-7809	-10155
XRN2	-6639	4794

---

---

Inhibition of Signaling by Overexpressed EGFR

Inhibition of Signaling by Overexpressed EGFR

metric	value
setSize	5
pMANOVA	0.0124
p.adjustMANOVA	0.034
s.dist	0.839
s.crp_eos_adj	0.368
s.crp_pod1_adj	0.754
p.crp_eos_adj	0.154
p.crp_pod1_adj	0.00351

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
TGFA	10866	10179
EREG	9740	9449
HBEGF	10781	8153

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AREG	-27	9240
EGF	-9895	1251
EREG	9740	9449
HBEGF	10781	8153
TGFA	10866	10179

---

---

Signaling by Overexpressed Wild-Type EGFR in Cancer

Signaling by Overexpressed Wild-Type EGFR in Cancer

metric	value
setSize	5
pMANOVA	0.0124
p.adjustMANOVA	0.034
s.dist	0.839
s.crp_eos_adj	0.368
s.crp_pod1_adj	0.754
p.crp_eos_adj	0.154
p.crp_pod1_adj	0.00351

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
TGFA	10866	10179
EREG	9740	9449
HBEGF	10781	8153

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AREG	-27	9240
EGF	-9895	1251
EREG	9740	9449
HBEGF	10781	8153
TGFA	10866	10179

---

---

rRNA processing

rRNA processing

metric	value
setSize	213
pMANOVA	1.54e-73
p.adjustMANOVA	9.87e-71
s.dist	0.825
s.crp_eos_adj	-0.666
s.crp_pod1_adj	-0.487
p.crp_eos_adj	2.46e-63
p.crp_pod1_adj	1.28e-34

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
EXOSC2	-9993	-10317
RPS13	-9860	-10007
RPS4X	-9749	-10114
MRM2	-9756	-10041
RPP40	-9156	-10510
RPL29	-9677	-9865
EXOSC8	-8869	-10610
RPL4	-9770	-9599
RPL7	-9845	-9516
RPS3A	-9753	-9470
RPL35A	-9836	-9385
RPL22L1	-9799	-9366
RPS7	-9854	-9266
RPL5	-9751	-9317
EXOSC5	-9057	-9963
RPL26	-9411	-9543
RPL34	-9456	-9427
RPS20	-9683	-9170
UTP6	-8655	-10027
RPL6	-9660	-8959

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
BMS1	-6502	-3025
BOP1	-6011	1839
BYSL	1430	2281
C1D	-6226	-5719
CSNK1D	3131	5516
CSNK1E	721	-4478
DCAF13	-6218	-9580
DDX21	-6537	6771
DDX47	-7576	-7898
DDX49	-8222	-6107
DDX52	3234	-2652
DHX37	-3440	2561
DIMT1	-6488	-5430
DIS3	2144	730
DKC1	-4817	-9683
EBNA1BP2	-9465	-4028
ELAC2	-6221	-1622
EMG1	-8067	-1412
ERI1	800	4136
EXOSC1	-9674	-8280
EXOSC10	2965	-6672
EXOSC2	-9993	-10317
EXOSC3	-2646	-8994
EXOSC4	-2632	598
EXOSC5	-9057	-9963
EXOSC6	-534	-5466
EXOSC7	-8843	-8057
EXOSC8	-8869	-10610
EXOSC9	-6969	-9530
FAU	-8641	-7814
FBL	-8319	-7774
FCF1	-2216	5019
FTSJ3	-2197	-311
GAR1	-623	-8511
GNL3	-8545	4331
HEATR1	7131	-1250
HSD17B10	-7509	-3437
IMP3	-8442	-9500
IMP4	-8272	-6908
ISG20L2	-4727	-6015
KRR1	-542	-1590
LAS1L	-5430	-10358
LTV1	-7049	-443
MPHOSPH10	-6310	-5552
MPHOSPH6	-7012	-396
MRM1	-6331	-5669
MRM2	-9756	-10041
MRM3	-8171	-8360
MT-ATP6	-8590	3553
MT-ATP8	-4983	3929
MT-CO1	-6917	-4576
MT-CO2	-9252	-1414
MT-CO3	-8758	-2658
MT-CYB	-7431	1487
MT-ND1	-9831	-5026
MT-ND2	-9907	-6098
MT-ND3	-9833	-4369
MT-ND4	-7222	3169
MT-ND4L	-8146	5942
MT-ND5	-6475	3484
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MTERF4	8151	-6921
NAT10	-3320	-3960
NCL	-6277	-3103
NHP2	-8805	-6768
NIP7	-4740	-1254
NOB1	-9207	-9214
NOC4L	-6978	-5122
NOL11	-6162	-7675
NOL12	-6933	-6195
NOL6	-5834	2782
NOL9	-905	-9121
NOP10	-6233	1935
NOP14	-7364	-6456
NOP2	-3370	-1032
NOP56	-8767	-6212
NOP58	-6181	-6529
NSUN4	-3045	-9970
PDCD11	159	-5969
PELP1	3157	-2162
PES1	-8648	-6272
PNO1	-6454	-4462
PRORP	-6160	3452
PWP2	1384	2629
RBM28	-1875	-10074
RCL1	-408	9406
RIOK1	-8623	-3889
RIOK2	417	3331
RIOK3	-5906	4774
RPL10	-9191	-9157
RPL10A	-9604	-8062
RPL11	-9287	-8896
RPL12	-9557	-8935
RPL13	-7061	-5779
RPL13A	-9155	-8597
RPL14	-9640	-8225
RPL15	-9548	-8811
RPL17	-9235	-8327
RPL18	-9266	-9330
RPL18A	-9051	-8191
RPL19	-9260	-8268
RPL21	-9652	-8541
RPL22	-9272	-9022
RPL22L1	-9799	-9366
RPL23	-9444	-7822
RPL23A	-8797	-8660
RPL24	-9824	-7978
RPL26	-9411	-9543
RPL26L1	-8467	1516
RPL27	-9542	-7228
RPL27A	-8939	-7185
RPL28	-7084	-6526
RPL29	-9677	-9865
RPL3	-8526	-8690
RPL30	-9222	-8630
RPL31	-9136	-8348
RPL32	-9297	-7784
RPL34	-9456	-9427
RPL35	-8986	-5304
RPL35A	-9836	-9385
RPL36	-7145	-5820
RPL36A	-9707	-8600
RPL36AL	-6354	318
RPL37	-7823	-6615
RPL37A	-9205	-6471
RPL38	-8249	-7501
RPL39	-9105	-8047
RPL39L	-8124	-9795
RPL3L	536	-8222
RPL4	-9770	-9599
RPL41	-9085	-6707
RPL5	-9751	-9317
RPL6	-9660	-8959
RPL7	-9845	-9516
RPL7A	-9558	-9004
RPL8	-9491	-8859
RPL9	-204	457
RPLP0	-8977	-5818
RPLP1	-6785	-4228
RPLP2	-6940	-6957
RPP14	-465	-395
RPP21	-7565	-8139
RPP25	-4754	-6262
RPP30	-3546	-10710
RPP38	-5668	-9680
RPP40	-9156	-10510
RPS10	-8944	-8544
RPS11	-9013	-8801
RPS12	-7926	-7498
RPS13	-9860	-10007
RPS14	-7795	-8270
RPS15	-8474	-7563
RPS15A	-9526	-7188
RPS16	-6192	-6988
RPS17	-8323	-4916
RPS18	-8015	-6292
RPS19	-8815	-6333
RPS2	-7546	-7616
RPS20	-9683	-9170
RPS21	-6557	-6310
RPS23	-9400	-7096
RPS24	-9564	-8137
RPS25	-9662	-8182
RPS26	7492	6246
RPS27	-9353	-6012
RPS27A	-8766	-8662
RPS27L	-8425	-7848
RPS28	-6430	-7076
RPS29	-6921	-2887
RPS3	-9183	-9224
RPS3A	-9753	-9470
RPS4X	-9749	-10114
RPS4Y1	-6859	-9435
RPS5	-8072	-5765
RPS6	-9487	-7609
RPS7	-9854	-9266
RPS8	-9588	-7508
RPS9	-9212	-4815
RPSA	-9233	-6584
RRP1	-5259	-7539
RRP36	-8740	-1054
RRP7A	-6664	-9222
RRP9	-7462	-9739
SENP3	-2541	118
SNU13	-8330	-9418
TBL3	-5991	-8193
TEX10	-2552	-9295
TFB1M	1922	-6960
THUMPD1	223	-5517
TRMT10C	-6898	-2465
TRMT112	-8876	-6800
TSR1	-8236	-10333
TSR3	-7647	-5907
UBA52	-9162	-8694
UTP11	-9033	-4480
UTP14A	-9659	-3758
UTP14C	-1047	-4734
UTP15	-269	-3749
UTP18	-9606	-2496
UTP20	4281	1686
UTP25	1546	-2777
UTP3	-4291	-2168
UTP4	-9947	-8458
UTP6	-8655	-10027
WDR12	-8790	-6680
WDR18	-6435	-6183
WDR3	-3913	-7730
WDR36	-3130	-3063
WDR43	-8393	86
WDR46	-9547	-6705
WDR75	-7809	-10155
XRN2	-6639	4794

---

---

Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

metric	value
setSize	6
pMANOVA	0.00944
p.adjustMANOVA	0.0272
s.dist	0.825
s.crp_eos_adj	-0.634
s.crp_pod1_adj	-0.527
p.crp_eos_adj	0.00716
p.crp_pod1_adj	0.0253

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
ECHS1	-8803	-10343
MECR	-9852	-6939
HADHA	-7929	-7170
HADH	-4768	-8384
HADHB	-4025	-2886

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ACADM	-2373	455
ECHS1	-8803	-10343
HADH	-4768	-8384
HADHA	-7929	-7170
HADHB	-4025	-2886
MECR	-9852	-6939

---

---

Synthesis of diphthamide-EEF2

Synthesis of diphthamide-EEF2

metric	value
setSize	8
pMANOVA	0.00203
p.adjustMANOVA	0.00737
s.dist	0.823
s.crp_eos_adj	-0.522
s.crp_pod1_adj	-0.636
p.crp_eos_adj	0.0105
p.crp_pod1_adj	0.00183

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
DPH2	-8829	-8379
EEF2	-6935	-9743
DPH7	-6398	-9705
DPH6	-5251	-10797
DPH5	-6832	-3671
DPH1	-2538	-8619
DNAJC24	-941	-10519

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
DNAJC24	-941	-10519
DPH1	-2538	-8619
DPH2	-8829	-8379
DPH3	-3165	5214
DPH5	-6832	-3671
DPH6	-5251	-10797
DPH7	-6398	-9705
EEF2	-6935	-9743

---

---

Processing of SMDT1

Processing of SMDT1

metric	value
setSize	15
pMANOVA	7.08e-06
p.adjustMANOVA	4.47e-05
s.dist	0.823
s.crp_eos_adj	-0.676
s.crp_pod1_adj	-0.47
p.crp_eos_adj	5.83e-06
p.crp_pod1_adj	0.00164

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
AFG3L2	-9828	-10494
PHB2	-9109	-9869
MCUB	-9112	-9192
PMPCB	-7457	-9109
MICU3	-7186	-8351
PHB	-9406	-5876
PMPCA	-5045	-10082
STOML2	-9218	-4492
SMDT1	-6128	-6366
MICU2	-4505	-3963
PARL	-8103	-579

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AFG3L2	-9828	-10494
MCU	-6873	3715
MCUB	-9112	-9192
MICU1	-6358	3473
MICU2	-4505	-3963
MICU3	-7186	-8351
PARL	-8103	-579
PHB	-9406	-5876
PHB2	-9109	-9869
PMPCA	-5045	-10082
PMPCB	-7457	-9109
SMDT1	-6128	-6366
SPG7	885	-8471
STOML2	-9218	-4492
YME1L1	-3508	686

---

---

Arachidonate production from DAG

Arachidonate production from DAG

metric	value
setSize	5
pMANOVA	0.0153
p.adjustMANOVA	0.0403
s.dist	0.814
s.crp_eos_adj	-0.738
s.crp_pod1_adj	-0.342
p.crp_eos_adj	0.00425
p.crp_pod1_adj	0.185

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
ABHD12	-9709	-8549
DAGLB	-6039	-5511
DAGLA	-1821	-7993
MGLL	-9522	-1043

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
ABHD12	-9709	-8549
ABHD6	-9878	3495
DAGLA	-1821	-7993
DAGLB	-6039	-5511
MGLL	-9522	-1043

---

---

rRNA modification in the mitochondrion

rRNA modification in the mitochondrion

metric	value
setSize	8
pMANOVA	0.00269
p.adjustMANOVA	0.00939
s.dist	0.801
s.crp_eos_adj	-0.483
s.crp_pod1_adj	-0.639
p.crp_eos_adj	0.0181
p.crp_pod1_adj	0.00176

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
MRM2	-9756	-10041
MRM3	-8171	-8360
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MRM1	-6331	-5669
NSUN4	-3045	-9970

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
MRM1	-6331	-5669
MRM2	-9756	-10041
MRM3	-8171	-8360
MT-RNR1	-10160	-4959
MT-RNR2	-10159	-3537
MTERF4	8151	-6921
NSUN4	-3045	-9970
TFB1M	1922	-6960

---

---

Mitochondrial calcium ion transport

Mitochondrial calcium ion transport

metric	value
setSize	22
pMANOVA	3.95e-08
p.adjustMANOVA	3.6e-07
s.dist	0.8
s.crp_eos_adj	-0.696
s.crp_pod1_adj	-0.395
p.crp_eos_adj	1.57e-08
p.crp_pod1_adj	0.00135

Top 20 genes

Gene	crp_eos_adj	crp_pod1_adj
VDAC3	-10015	-10330
AFG3L2	-9828	-10494
PHB2	-9109	-9869
MCUB	-9112	-9192
AKAP1	-9268	-8448
PMPCB	-7457	-9109
VDAC2	-9258	-6780
MICU3	-7186	-8351
PHB	-9406	-5876
PMPCA	-5045	-10082
STOML2	-9218	-4492
SMDT1	-6128	-6366
MICU2	-4505	-3963
VDAC1	-9658	-1564
PARL	-8103	-579

Click HERE to show all gene set members

All member genes

	crp_eos_adj	crp_pod1_adj
AFG3L2	-9828	-10494
AKAP1	-9268	-8448
LETM1	-4469	4125
MCU	-6873	3715
MCUB	-9112	-9192
MICU1	-6358	3473
MICU2	-4505	-3963
MICU3	-7186	-8351
PARL	-8103	-579
PHB	-9406	-5876
PHB2	-9109	-9869
PMPCA	-5045	-10082
PMPCB	-7457	-9109
SLC8A3	-9909	870
SLC8B1	816	2671
SMDT1	-6128	-6366
SPG7	885	-8471
STOML2	-9218	-4492
VDAC1	-9658	-1564
VDAC2	-9258	-6780
VDAC3	-10015	-10330
YME1L1	-3508	686

---

---

Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## Network charts only generated in one-dimensional analysis.

Session information

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] gtools_3.9.5                RhpcBLASctl_0.23-42        
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] eulerr_7.1.0                ggplot2_4.0.3              
##  [7] kableExtra_1.4.0            MASS_7.3-65                
##  [9] mitch_1.22.1                DESeq2_1.50.2              
## [11] SummarizedExperiment_1.40.0 Biobase_2.70.0             
## [13] MatrixGenerics_1.22.0       matrixStats_1.5.0          
## [15] GenomicRanges_1.62.1        Seqinfo_1.0.0              
## [17] IRanges_2.44.0              S4Vectors_0.48.1           
## [19] BiocGenerics_0.56.0         generics_0.1.4             
## [21] dplyr_1.2.1                 WGCNA_1.74                 
## [23] fastcluster_1.3.0           dynamicTreeCut_1.63-1      
## [25] reshape2_1.4.5              gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] Hmisc_5.2-5           labeling_0.4.3        polyclip_1.10-7      
##  [37] abind_1.4-8           compiler_4.5.2        withr_3.0.2          
##  [40] doParallel_1.0.17     htmlTable_2.5.0       S7_0.2.2             
##  [43] backports_1.5.1       BiocParallel_1.44.0   ggstats_0.13.0       
##  [46] DelayedArray_0.36.1   caTools_1.18.3        tools_4.5.2          
##  [49] foreign_0.8-90        otel_0.2.0            beeswarm_0.4.0       
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.4     xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report