date generated: 2026-06-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
dex_eos_adj dex_pod1_adj
5_8S_rRNA 2.3372330 -1.6789077
A1BG -0.1044447 0.4773455
A1BG-AS1 0.3112347 -0.3881907
A1CF 0.9717804 0.3059609
A2M 2.6139639 -0.6340972
A2M-AS1 2.4240591 1.0223691

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 21129
duplicated_genes_present 0
num_profile_genes_in_sets 8679
num_profile_genes_not_in_sets 12450
profile_pearson_correl -0.04063
profile_spearman_correl -0.08

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1199
num_genesets_included 1526

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 407

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.dex_eos_adj s.dex_pod1_adj p.dex_eos_adj p.dex_pod1_adj
Protein repair 6 3.06e-04 2.94e-03 0.985 0.7430 -0.6460 1.61e-03 6.11e-03
G2/M DNA replication checkpoint 5 3.45e-03 2.16e-02 0.903 0.6010 -0.6740 1.99e-02 9.03e-03
Neurotransmitter clearance 6 7.09e-04 5.63e-03 0.864 0.4620 0.7300 5.00e-02 1.95e-03
Interleukin-21 signaling 9 3.94e-05 5.48e-04 0.832 -0.5120 -0.6560 7.84e-03 6.48e-04
Response to metal ions 6 3.39e-03 2.14e-02 0.825 0.5000 -0.6560 3.41e-02 5.37e-03
Tandem pore domain potassium channels 5 4.96e-03 2.78e-02 0.810 -0.6850 -0.4320 8.00e-03 9.42e-02
Fructose metabolism 7 1.72e-03 1.20e-02 0.804 -0.3890 0.7030 7.46e-02 1.27e-03
CD163 mediating an anti-inflammatory response 8 5.31e-04 4.51e-03 0.786 0.7830 0.0583 1.24e-04 7.75e-01
Activation of caspases through apoptosome-mediated cleavage 6 3.86e-03 2.36e-02 0.781 -0.0288 -0.7810 9.03e-01 9.28e-04
RUNX1 regulates transcription of genes involved in BCR signaling 6 6.65e-03 3.48e-02 0.769 0.6890 -0.3420 3.48e-03 1.47e-01
MECP2 regulates transcription of neuronal ligands 5 9.95e-03 4.72e-02 0.764 -0.7270 -0.2340 4.85e-03 3.65e-01
ARMS-mediated activation 6 9.69e-03 4.63e-02 0.738 0.2960 -0.6750 2.09e-01 4.17e-03
G2 Phase 5 2.30e-02 9.24e-02 0.734 0.6140 -0.4030 1.74e-02 1.19e-01
Defective binding of VWF variant to GPIb:IX:V 5 1.90e-02 7.91e-02 0.734 0.7240 -0.1210 5.04e-03 6.40e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 1.90e-02 7.91e-02 0.734 0.7240 -0.1210 5.04e-03 6.40e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 2.39e-02 9.57e-02 0.730 -0.3780 0.6240 1.43e-01 1.57e-02
ROBO receptors bind AKAP5 7 2.62e-03 1.72e-02 0.724 -0.4090 -0.5970 6.12e-02 6.22e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 4.83e-03 2.73e-02 0.721 0.1360 -0.7080 5.34e-01 1.17e-03
Butyrophilin (BTN) family interactions 9 1.27e-03 9.30e-03 0.720 -0.2590 0.6720 1.78e-01 4.79e-04
Fructose catabolism 5 2.48e-02 9.76e-02 0.720 -0.2670 0.6690 3.00e-01 9.62e-03
Regulation of IFNA/IFNB signaling 12 7.49e-05 9.10e-04 0.709 -0.2040 -0.6790 2.21e-01 4.65e-05
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.00e-07 1.01e-05 0.705 0.6900 0.1470 1.91e-07 2.68e-01
Replacement of protamines by nucleosomes in the male pronucleus 12 2.68e-04 2.73e-03 0.696 0.6280 -0.3000 1.66e-04 7.18e-02
Establishment of Sister Chromatid Cohesion 11 3.84e-04 3.48e-03 0.690 0.0150 -0.6890 9.31e-01 7.51e-05
CD22 mediated BCR regulation 57 5.61e-17 5.39e-15 0.688 0.5190 -0.4510 1.19e-11 3.83e-09
LTC4-CYSLTR mediated IL4 production 5 2.22e-02 9.01e-02 0.686 -0.5730 -0.3770 2.66e-02 1.44e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 4.30e-02 1.44e-01 0.673 -0.4590 0.4920 7.54e-02 5.66e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 5 3.21e-02 1.18e-01 0.667 -0.0993 -0.6600 7.01e-01 1.06e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 3.04e-02 1.15e-01 0.655 0.4720 0.4540 6.78e-02 7.86e-02
Phenylalanine metabolism 5 5.14e-02 1.63e-01 0.653 -0.5120 0.4060 4.74e-02 1.16e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.84e-04 4.17e-03 0.650 0.4700 -0.4490 3.32e-03 5.05e-03
Formation of the active cofactor, UDP-glucuronate 5 5.48e-02 1.69e-01 0.647 0.4760 -0.4380 6.53e-02 9.01e-02
SMAC (DIABLO) binds to IAPs 7 1.12e-02 5.18e-02 0.646 -0.0786 -0.6410 7.19e-01 3.32e-03
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.12e-02 5.18e-02 0.646 -0.0786 -0.6410 7.19e-01 3.32e-03
SMAC, XIAP-regulated apoptotic response 7 1.12e-02 5.18e-02 0.646 -0.0786 -0.6410 7.19e-01 3.32e-03
Regulation of NPAS4 gene expression 11 5.91e-04 4.92e-03 0.644 -0.4100 -0.4970 1.84e-02 4.34e-03
Regulation of TP53 Activity through Association with Co-factors 11 1.70e-03 1.20e-02 0.637 -0.2330 0.5930 1.81e-01 6.57e-04
Type I hemidesmosome assembly 8 5.52e-03 3.06e-02 0.637 -0.2760 -0.5740 1.77e-01 4.94e-03
Condensation of Prometaphase Chromosomes 11 1.93e-03 1.33e-02 0.635 0.2880 -0.5650 9.78e-02 1.17e-03
OAS antiviral response 8 5.60e-03 3.09e-02 0.633 -0.3290 -0.5410 1.07e-01 8.06e-03
MET activates PI3K/AKT signaling 5 6.29e-02 1.84e-01 0.631 0.4350 -0.4580 9.22e-02 7.64e-02
Maturation of protein 3a 9683673 9 3.88e-03 2.36e-02 0.628 -0.1420 -0.6120 4.61e-01 1.47e-03
Maturation of protein 3a 9694719 9 3.88e-03 2.36e-02 0.628 -0.1420 -0.6120 4.61e-01 1.47e-03
RHOT1 GTPase cycle 5 6.37e-02 1.85e-01 0.626 0.5480 -0.3020 3.39e-02 2.42e-01
Scavenging of heme from plasma 69 7.45e-17 6.82e-15 0.623 0.4580 -0.4230 4.79e-11 1.27e-09
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 2.24e-02 9.06e-02 0.620 -0.5520 0.2820 1.14e-02 1.97e-01
Interleukin-6 signaling 10 2.45e-03 1.62e-02 0.619 -0.1640 -0.5960 3.69e-01 1.09e-03
FCGR activation 75 7.51e-18 8.48e-16 0.616 0.4090 -0.4600 8.99e-10 5.45e-12
Biosynthesis of Lipoxins (LX) 6 3.71e-02 1.30e-01 0.615 0.5960 -0.1490 1.14e-02 5.27e-01
Propionyl-CoA catabolism 5 6.33e-02 1.84e-01 0.615 -0.6020 0.1240 1.98e-02 6.30e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.dex_eos_adj s.dex_pod1_adj p.dex_eos_adj p.dex_pod1_adj
Protein repair 6 3.06e-04 2.94e-03 0.98500 0.743000 -0.646000 1.61e-03 6.11e-03
G2/M DNA replication checkpoint 5 3.45e-03 2.16e-02 0.90300 0.601000 -0.674000 1.99e-02 9.03e-03
Neurotransmitter clearance 6 7.09e-04 5.63e-03 0.86400 0.462000 0.730000 5.00e-02 1.95e-03
Interleukin-21 signaling 9 3.94e-05 5.48e-04 0.83200 -0.512000 -0.656000 7.84e-03 6.48e-04
Response to metal ions 6 3.39e-03 2.14e-02 0.82500 0.500000 -0.656000 3.41e-02 5.37e-03
Tandem pore domain potassium channels 5 4.96e-03 2.78e-02 0.81000 -0.685000 -0.432000 8.00e-03 9.42e-02
Fructose metabolism 7 1.72e-03 1.20e-02 0.80400 -0.389000 0.703000 7.46e-02 1.27e-03
CD163 mediating an anti-inflammatory response 8 5.31e-04 4.51e-03 0.78600 0.783000 0.058300 1.24e-04 7.75e-01
Activation of caspases through apoptosome-mediated cleavage 6 3.86e-03 2.36e-02 0.78100 -0.028800 -0.781000 9.03e-01 9.28e-04
RUNX1 regulates transcription of genes involved in BCR signaling 6 6.65e-03 3.48e-02 0.76900 0.689000 -0.342000 3.48e-03 1.47e-01
MECP2 regulates transcription of neuronal ligands 5 9.95e-03 4.72e-02 0.76400 -0.727000 -0.234000 4.85e-03 3.65e-01
ARMS-mediated activation 6 9.69e-03 4.63e-02 0.73800 0.296000 -0.675000 2.09e-01 4.17e-03
G2 Phase 5 2.30e-02 9.24e-02 0.73400 0.614000 -0.403000 1.74e-02 1.19e-01
Defective binding of VWF variant to GPIb:IX:V 5 1.90e-02 7.91e-02 0.73400 0.724000 -0.121000 5.04e-03 6.40e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 1.90e-02 7.91e-02 0.73400 0.724000 -0.121000 5.04e-03 6.40e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 2.39e-02 9.57e-02 0.73000 -0.378000 0.624000 1.43e-01 1.57e-02
ROBO receptors bind AKAP5 7 2.62e-03 1.72e-02 0.72400 -0.409000 -0.597000 6.12e-02 6.22e-03
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 4.83e-03 2.73e-02 0.72100 0.136000 -0.708000 5.34e-01 1.17e-03
Butyrophilin (BTN) family interactions 9 1.27e-03 9.30e-03 0.72000 -0.259000 0.672000 1.78e-01 4.79e-04
Fructose catabolism 5 2.48e-02 9.76e-02 0.72000 -0.267000 0.669000 3.00e-01 9.62e-03
Regulation of IFNA/IFNB signaling 12 7.49e-05 9.10e-04 0.70900 -0.204000 -0.679000 2.21e-01 4.65e-05
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 4.00e-07 1.01e-05 0.70500 0.690000 0.147000 1.91e-07 2.68e-01
Replacement of protamines by nucleosomes in the male pronucleus 12 2.68e-04 2.73e-03 0.69600 0.628000 -0.300000 1.66e-04 7.18e-02
Establishment of Sister Chromatid Cohesion 11 3.84e-04 3.48e-03 0.69000 0.015000 -0.689000 9.31e-01 7.51e-05
CD22 mediated BCR regulation 57 5.61e-17 5.39e-15 0.68800 0.519000 -0.451000 1.19e-11 3.83e-09
LTC4-CYSLTR mediated IL4 production 5 2.22e-02 9.01e-02 0.68600 -0.573000 -0.377000 2.66e-02 1.44e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 4.30e-02 1.44e-01 0.67300 -0.459000 0.492000 7.54e-02 5.66e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 5 3.21e-02 1.18e-01 0.66700 -0.099300 -0.660000 7.01e-01 1.06e-02
RUNX3 regulates BCL2L11 (BIM) transcription 5 3.04e-02 1.15e-01 0.65500 0.472000 0.454000 6.78e-02 7.86e-02
Phenylalanine metabolism 5 5.14e-02 1.63e-01 0.65300 -0.512000 0.406000 4.74e-02 1.16e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.84e-04 4.17e-03 0.65000 0.470000 -0.449000 3.32e-03 5.05e-03
Formation of the active cofactor, UDP-glucuronate 5 5.48e-02 1.69e-01 0.64700 0.476000 -0.438000 6.53e-02 9.01e-02
SMAC (DIABLO) binds to IAPs 7 1.12e-02 5.18e-02 0.64600 -0.078600 -0.641000 7.19e-01 3.32e-03
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.12e-02 5.18e-02 0.64600 -0.078600 -0.641000 7.19e-01 3.32e-03
SMAC, XIAP-regulated apoptotic response 7 1.12e-02 5.18e-02 0.64600 -0.078600 -0.641000 7.19e-01 3.32e-03
Regulation of NPAS4 gene expression 11 5.91e-04 4.92e-03 0.64400 -0.410000 -0.497000 1.84e-02 4.34e-03
Regulation of TP53 Activity through Association with Co-factors 11 1.70e-03 1.20e-02 0.63700 -0.233000 0.593000 1.81e-01 6.57e-04
Type I hemidesmosome assembly 8 5.52e-03 3.06e-02 0.63700 -0.276000 -0.574000 1.77e-01 4.94e-03
Condensation of Prometaphase Chromosomes 11 1.93e-03 1.33e-02 0.63500 0.288000 -0.565000 9.78e-02 1.17e-03
OAS antiviral response 8 5.60e-03 3.09e-02 0.63300 -0.329000 -0.541000 1.07e-01 8.06e-03
MET activates PI3K/AKT signaling 5 6.29e-02 1.84e-01 0.63100 0.435000 -0.458000 9.22e-02 7.64e-02
Maturation of protein 3a 9683673 9 3.88e-03 2.36e-02 0.62800 -0.142000 -0.612000 4.61e-01 1.47e-03
Maturation of protein 3a 9694719 9 3.88e-03 2.36e-02 0.62800 -0.142000 -0.612000 4.61e-01 1.47e-03
RHOT1 GTPase cycle 5 6.37e-02 1.85e-01 0.62600 0.548000 -0.302000 3.39e-02 2.42e-01
Scavenging of heme from plasma 69 7.45e-17 6.82e-15 0.62300 0.458000 -0.423000 4.79e-11 1.27e-09
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 2.24e-02 9.06e-02 0.62000 -0.552000 0.282000 1.14e-02 1.97e-01
Interleukin-6 signaling 10 2.45e-03 1.62e-02 0.61900 -0.164000 -0.596000 3.69e-01 1.09e-03
FCGR activation 75 7.51e-18 8.48e-16 0.61600 0.409000 -0.460000 8.99e-10 5.45e-12
Biosynthesis of Lipoxins (LX) 6 3.71e-02 1.30e-01 0.61500 0.596000 -0.149000 1.14e-02 5.27e-01
Propionyl-CoA catabolism 5 6.33e-02 1.84e-01 0.61500 -0.602000 0.124000 1.98e-02 6.30e-01
Mitochondrial RNA degradation 25 5.02e-07 1.22e-05 0.61300 0.605000 0.095300 1.61e-07 4.10e-01
Wax and plasmalogen biosynthesis 5 6.08e-02 1.81e-01 0.61200 0.032800 -0.611000 8.99e-01 1.80e-02
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 6 3.48e-02 1.25e-01 0.61000 0.015100 -0.610000 9.49e-01 9.67e-03
Role of LAT2/NTAL/LAB on calcium mobilization 76 1.47e-17 1.57e-15 0.60700 0.417000 -0.441000 3.32e-10 3.02e-11
Regulation of CDH11 mRNA translation by microRNAs 8 8.70e-03 4.22e-02 0.60300 -0.451000 -0.401000 2.71e-02 4.97e-02
Regulation of NPAS4 mRNA translation 8 8.70e-03 4.22e-02 0.60300 -0.451000 -0.401000 2.71e-02 4.97e-02
Translocation of ZAP-70 to Immunological synapse 24 3.07e-06 5.98e-05 0.60200 -0.589000 0.121000 5.77e-07 3.03e-01
RNA Polymerase I Promoter Opening 17 2.05e-04 2.20e-03 0.59700 0.510000 -0.311000 2.75e-04 2.63e-02
Classical antibody-mediated complement activation 68 2.63e-15 1.87e-13 0.59600 0.463000 -0.376000 4.00e-11 8.38e-08
Formyl peptide receptors bind formyl peptides and many other ligands 7 3.14e-02 1.16e-01 0.59500 0.352000 -0.480000 1.07e-01 2.77e-02
Formation of xylulose-5-phosphate 5 8.24e-02 2.22e-01 0.59100 -0.553000 0.210000 3.24e-02 4.17e-01
Defective LFNG causes SCDO3 5 6.24e-02 1.84e-01 0.59000 -0.544000 -0.228000 3.53e-02 3.77e-01
MET activates RAP1 and RAC1 10 7.99e-03 4.00e-02 0.58800 0.491000 -0.324000 7.21e-03 7.64e-02
Toxicity of botulinum toxin type D (botD) 5 9.16e-02 2.38e-01 0.58600 -0.362000 0.461000 1.61e-01 7.43e-02
Toxicity of botulinum toxin type F (botF) 5 9.16e-02 2.38e-01 0.58600 -0.362000 0.461000 1.61e-01 7.43e-02
tRNA processing in the mitochondrion 24 2.58e-06 5.15e-05 0.58600 0.570000 0.133000 1.31e-06 2.58e-01
Mitotic Telophase/Cytokinesis 13 1.11e-03 8.29e-03 0.57900 -0.128000 -0.565000 4.24e-01 4.24e-04
Chromatin modifications during the maternal to zygotic transition (MZT) 23 2.07e-05 3.29e-04 0.57800 0.504000 -0.282000 2.85e-05 1.93e-02
Synthesis of PI 5 9.49e-02 2.44e-01 0.57600 -0.524000 0.240000 4.25e-02 3.52e-01
POLB-Dependent Long Patch Base Excision Repair 8 2.15e-02 8.83e-02 0.57600 -0.553000 0.161000 6.71e-03 4.30e-01
Cobalamin (Cbl) metabolism 7 2.44e-02 9.66e-02 0.57400 -0.262000 -0.511000 2.30e-01 1.92e-02
RUNX1 regulates expression of components of tight junctions 5 1.01e-01 2.55e-01 0.57300 0.484000 -0.305000 6.07e-02 2.37e-01
RUNX3 regulates CDKN1A transcription 7 3.37e-02 1.22e-01 0.57200 -0.065300 0.568000 7.65e-01 9.27e-03
ATF6 (ATF6-alpha) activates chaperones 12 4.17e-03 2.48e-02 0.57100 0.483000 -0.304000 3.74e-03 6.80e-02
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 7.65e-02 2.11e-01 0.57100 -0.168000 -0.546000 5.15e-01 3.46e-02
Estrogen-stimulated signaling through PRKCZ 6 6.42e-02 1.86e-01 0.56800 0.516000 -0.237000 2.85e-02 3.15e-01
MASTL Facilitates Mitotic Progression 10 1.11e-02 5.18e-02 0.56700 0.293000 -0.485000 1.09e-01 7.91e-03
Post-transcriptional silencing by small RNAs 7 2.64e-02 1.02e-01 0.56500 -0.378000 -0.419000 8.33e-02 5.47e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 1.11e-02 5.18e-02 0.56400 0.504000 -0.255000 5.80e-03 1.63e-01
Glucuronidation 8 3.07e-02 1.16e-01 0.56000 0.417000 -0.373000 4.11e-02 6.74e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 1.29e-02 5.81e-02 0.55900 -0.082500 -0.553000 6.68e-01 4.06e-03
Diseases of Mismatch Repair (MMR) 5 9.94e-02 2.52e-01 0.55900 0.076200 -0.554000 7.68e-01 3.20e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 14 2.32e-03 1.57e-02 0.55400 -0.492000 0.255000 1.44e-03 9.79e-02
Acetylcholine Neurotransmitter Release Cycle 11 8.64e-03 4.22e-02 0.55400 -0.488000 0.263000 5.11e-03 1.31e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 82 8.45e-16 6.56e-14 0.55200 0.360000 -0.419000 1.67e-08 5.47e-11
Maturation of hRSV A proteins 13 4.07e-03 2.44e-02 0.55200 0.369000 -0.411000 2.14e-02 1.03e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 3.05e-02 1.15e-01 0.55200 -0.519000 0.188000 1.10e-02 3.56e-01
Creation of C4 and C2 activators 70 1.51e-13 8.29e-12 0.55100 0.427000 -0.348000 6.18e-10 4.78e-07
Ca2+ activated K+ channels 6 5.64e-02 1.71e-01 0.55100 0.173000 0.523000 4.64e-01 2.66e-02
NADE modulates death signalling 5 1.23e-01 2.90e-01 0.54800 0.327000 -0.440000 2.05e-01 8.83e-02
Interleukin-9 signaling 8 2.05e-02 8.44e-02 0.54800 -0.285000 -0.469000 1.63e-01 2.17e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 2.15e-04 2.27e-03 0.54800 0.476000 -0.273000 2.31e-04 3.46e-02
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.24e-01 2.90e-01 0.54800 0.364000 -0.409000 1.59e-01 1.13e-01
AKT phosphorylates targets in the nucleus 9 2.46e-02 9.71e-02 0.54300 -0.312000 0.444000 1.05e-01 2.10e-02
Common Pathway of Fibrin Clot Formation 13 4.71e-03 2.69e-02 0.54300 0.296000 -0.455000 6.49e-02 4.47e-03
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 4.42e-02 1.46e-01 0.54100 0.027400 0.540000 9.00e-01 1.33e-02
Platelet sensitization by LDL 16 1.10e-03 8.27e-03 0.54100 0.120000 -0.527000 4.05e-01 2.62e-04
Interleukin-20 family signaling 17 3.53e-04 3.28e-03 0.54000 -0.230000 -0.489000 1.01e-01 4.79e-04
Cytosolic iron-sulfur cluster assembly 13 4.30e-03 2.54e-02 0.53900 -0.161000 0.515000 3.16e-01 1.30e-03
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 8.73e-02 2.29e-01 0.53800 0.470000 -0.261000 4.63e-02 2.68e-01
FCGR3A-mediated phagocytosis 120 1.51e-21 3.23e-19 0.53700 0.334000 -0.420000 2.51e-10 1.87e-15
Leishmania phagocytosis 120 1.51e-21 3.23e-19 0.53700 0.334000 -0.420000 2.51e-10 1.87e-15
Parasite infection 120 1.51e-21 3.23e-19 0.53700 0.334000 -0.420000 2.51e-10 1.87e-15
Cohesin Loading onto Chromatin 10 1.22e-02 5.53e-02 0.53500 -0.062500 -0.532000 7.32e-01 3.60e-03
Regulation of RUNX1 Expression and Activity 18 2.86e-04 2.85e-03 0.53300 -0.201000 -0.494000 1.40e-01 2.83e-04
Regulation of IFNG signaling 14 3.47e-03 2.16e-02 0.53300 0.205000 -0.492000 1.84e-01 1.43e-03
Regulation of PTEN localization 9 2.95e-02 1.12e-01 0.53100 0.338000 -0.409000 7.92e-02 3.36e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.17e-02 5.35e-02 0.52800 -0.210000 -0.484000 2.50e-01 8.04e-03
FCERI mediated Ca+2 mobilization 91 8.54e-16 6.56e-14 0.52400 0.317000 -0.417000 1.65e-07 6.23e-12
Synthesis of 5-eicosatetraenoic acids 7 4.39e-02 1.45e-01 0.52300 0.373000 0.367000 8.75e-02 9.24e-02
DNA methylation 18 1.09e-03 8.20e-03 0.52300 0.383000 -0.355000 4.89e-03 9.06e-03
Regulation of CDH19 Expression and Function 5 1.49e-01 3.27e-01 0.51900 -0.238000 0.462000 3.57e-01 7.38e-02
Reelin signalling pathway 5 1.53e-01 3.32e-01 0.51800 0.268000 -0.443000 2.99e-01 8.65e-02
RHO GTPases activate IQGAPs 25 9.51e-05 1.10e-03 0.51700 0.379000 -0.351000 1.04e-03 2.38e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 3.54e-02 1.26e-01 0.51600 0.310000 -0.413000 1.07e-01 3.20e-02
Crosslinking of collagen fibrils 12 6.02e-03 3.24e-02 0.51500 0.232000 0.460000 1.64e-01 5.82e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.42e-02 9.63e-02 0.51400 0.455000 -0.239000 1.28e-02 1.90e-01
Defects of platelet adhesion to exposed collagen 6 9.51e-02 2.44e-01 0.51200 0.511000 -0.026800 3.01e-02 9.09e-01
Estrogen biosynthesis 5 1.51e-01 3.29e-01 0.51100 0.493000 -0.138000 5.65e-02 5.94e-01
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 5.51e-02 1.69e-01 0.51100 -0.168000 -0.483000 4.43e-01 2.69e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 6.23e-02 1.84e-01 0.50800 0.505000 0.053400 2.06e-02 8.07e-01
Prolonged ERK activation events 13 9.54e-03 4.57e-02 0.50800 0.353000 -0.365000 2.73e-02 2.29e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.16e-02 5.31e-02 0.50800 0.486000 -0.145000 3.53e-03 3.83e-01
Regulation of CDH11 gene transcription 5 1.64e-01 3.44e-01 0.50500 -0.456000 0.218000 7.76e-02 3.99e-01
PD-1 signaling 28 2.78e-05 4.20e-04 0.50200 -0.500000 0.050100 4.66e-06 6.47e-01
Coenzyme A biosynthesis 7 6.63e-02 1.90e-01 0.50100 -0.496000 -0.071500 2.30e-02 7.43e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 6.37e-03 3.39e-02 0.50000 0.138000 -0.481000 3.73e-01 1.85e-03
Packaging Of Telomere Ends 18 1.89e-03 1.31e-02 0.49900 0.415000 -0.279000 2.32e-03 4.08e-02
RHO GTPases activate PKNs 46 1.08e-07 2.89e-06 0.49900 0.420000 -0.270000 8.11e-07 1.54e-03
Regulation of actin dynamics for phagocytic cup formation 122 4.85e-19 9.31e-17 0.49900 0.299000 -0.400000 1.22e-08 2.33e-14
Transcriptional regulation of testis differentiation 5 1.60e-01 3.40e-01 0.49900 -0.076000 0.493000 7.68e-01 5.64e-02
Platelet Adhesion to exposed collagen 14 8.14e-03 4.03e-02 0.49600 0.408000 -0.282000 8.16e-03 6.79e-02
Binding and Uptake of Ligands by Scavenger Receptors 89 6.60e-14 3.84e-12 0.49600 0.372000 -0.329000 1.34e-09 8.39e-08
Phosphorylation of CD3 and TCR zeta chains 27 4.60e-05 6.09e-04 0.49500 -0.495000 -0.007560 8.63e-06 9.46e-01
Signal attenuation 9 3.53e-02 1.25e-01 0.49500 0.494000 0.021400 1.03e-02 9.12e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 4.37e-03 2.56e-02 0.49400 0.307000 -0.387000 3.37e-02 7.31e-03
Proton-coupled monocarboxylate transport 6 1.29e-01 2.97e-01 0.49300 0.425000 -0.250000 7.16e-02 2.89e-01
FCGR3A-mediated IL10 synthesis 98 4.26e-15 2.92e-13 0.49300 0.292000 -0.397000 5.67e-07 1.11e-11
Frs2-mediated activation 11 2.57e-02 1.01e-01 0.49000 0.354000 -0.338000 4.21e-02 5.21e-02
Signaling by PDGFRA extracellular domain mutants 12 1.38e-02 6.09e-02 0.48800 0.023700 -0.488000 8.87e-01 3.43e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.38e-02 6.09e-02 0.48800 0.023700 -0.488000 8.87e-01 3.43e-03
Miro GTPase Cycle 8 6.61e-02 1.90e-01 0.48700 0.456000 -0.172000 2.55e-02 4.01e-01
Role of phospholipids in phagocytosis 87 4.04e-13 2.10e-11 0.48600 0.318000 -0.368000 2.87e-07 2.96e-09
Modulation by Mtb of host immune system 7 8.52e-02 2.25e-01 0.48500 0.484000 -0.032400 2.65e-02 8.82e-01
FCERI mediated MAPK activation 92 1.01e-13 5.70e-12 0.48400 0.312000 -0.370000 2.23e-07 8.25e-10
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.39e-02 6.10e-02 0.48000 0.447000 -0.174000 5.23e-03 2.76e-01
FCERI mediated NF-kB activation 128 1.84e-18 2.94e-16 0.48000 0.300000 -0.374000 4.51e-09 2.50e-13
Carnitine shuttle 12 1.71e-02 7.27e-02 0.47900 -0.475000 0.059900 4.37e-03 7.20e-01
Netrin mediated repulsion signals 5 1.56e-01 3.35e-01 0.47800 -0.308000 -0.366000 2.33e-01 1.57e-01
Presynaptic depolarization and calcium channel opening 8 7.92e-02 2.15e-01 0.47800 -0.318000 0.356000 1.19e-01 8.11e-02
Digestion 5 1.92e-01 3.79e-01 0.47500 0.467000 -0.086000 7.07e-02 7.39e-01
Scavenging by Class F Receptors 5 1.79e-01 3.63e-01 0.47200 -0.073500 -0.466000 7.76e-01 7.11e-02
COPI-independent Golgi-to-ER retrograde traffic 45 9.55e-07 2.21e-05 0.47100 0.285000 -0.374000 9.36e-04 1.39e-05
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 2.13e-01 4.00e-01 0.47000 -0.256000 0.395000 3.22e-01 1.26e-01
Defective factor IX causes hemophilia B 6 1.42e-01 3.16e-01 0.47000 0.463000 -0.080300 4.93e-02 7.34e-01
Anti-inflammatory response favouring Leishmania parasite infection 130 6.83e-18 8.20e-16 0.46800 0.290000 -0.368000 1.12e-08 4.34e-13
Leishmania parasite growth and survival 130 6.83e-18 8.20e-16 0.46800 0.290000 -0.368000 1.12e-08 4.34e-13
Long-term potentiation 14 1.38e-02 6.10e-02 0.46800 -0.387000 0.264000 1.23e-02 8.76e-02
Regulation of Complement cascade 95 2.68e-13 1.43e-11 0.46700 0.394000 -0.251000 3.18e-11 2.29e-05
ChREBP activates metabolic gene expression 7 1.17e-01 2.83e-01 0.46700 0.233000 -0.405000 2.86e-01 6.36e-02
CREB phosphorylation 7 1.03e-01 2.60e-01 0.46600 0.026600 -0.465000 9.03e-01 3.32e-02
SUMO is proteolytically processed 6 1.30e-01 2.99e-01 0.46600 -0.115000 -0.451000 6.24e-01 5.57e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 4.41e-03 2.58e-02 0.46500 -0.111000 -0.452000 4.43e-01 1.74e-03
N-Glycan antennae elongation 12 2.21e-02 9.01e-02 0.46400 0.065800 -0.459000 6.93e-01 5.87e-03
Interferon alpha/beta signaling 63 4.95e-10 1.67e-08 0.46400 -0.154000 -0.437000 3.43e-02 1.91e-09
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 1.16e-01 2.80e-01 0.46300 -0.149000 0.439000 4.95e-01 4.44e-02
NFE2L2 regulates pentose phosphate pathway genes 8 8.90e-02 2.32e-01 0.46300 0.409000 -0.218000 4.52e-02 2.86e-01
Formation of Fibrin Clot (Clotting Cascade) 26 4.32e-04 3.79e-03 0.46300 0.347000 -0.307000 2.19e-03 6.75e-03
Phosphorylation of Emi1 6 1.53e-01 3.32e-01 0.46300 0.097000 -0.453000 6.81e-01 5.47e-02
p130Cas linkage to MAPK signaling for integrins 11 3.71e-02 1.30e-01 0.46300 0.386000 -0.255000 2.65e-02 1.43e-01
Assembly of the ORC complex at the origin of replication 23 1.11e-03 8.29e-03 0.46200 0.336000 -0.316000 5.23e-03 8.66e-03
ADP signalling through P2Y purinoceptor 12 18 4.92e-03 2.77e-02 0.46000 0.275000 -0.370000 4.38e-02 6.63e-03
STAT3 nuclear events downstream of ALK signaling 11 2.41e-02 9.63e-02 0.46000 -0.416000 -0.195000 1.68e-02 2.62e-01
GDP-fucose biosynthesis 6 1.56e-01 3.35e-01 0.46000 -0.085000 0.452000 7.18e-01 5.54e-02
Initial triggering of complement 78 1.19e-10 4.38e-09 0.45900 0.359000 -0.287000 4.21e-08 1.18e-05
RSK activation 7 1.27e-01 2.94e-01 0.45900 0.386000 -0.248000 7.71e-02 2.56e-01
Polo-like kinase mediated events 16 8.48e-03 4.16e-02 0.45900 0.189000 -0.418000 1.90e-01 3.82e-03
rRNA processing in the mitochondrion 24 3.86e-04 3.48e-03 0.45800 0.446000 0.104000 1.54e-04 3.80e-01
Sperm Motility And Taxes 6 1.57e-01 3.35e-01 0.45700 -0.453000 0.061800 5.48e-02 7.93e-01
G0 and Early G1 27 2.40e-04 2.49e-03 0.45600 0.042400 -0.454000 7.03e-01 4.45e-05
Signaling by PDGFR in disease 19 2.57e-03 1.69e-02 0.45500 -0.011200 -0.455000 9.33e-01 5.92e-04
ALK mutants bind TKIs 11 2.79e-02 1.07e-01 0.45400 -0.132000 -0.435000 4.48e-01 1.25e-02
Thyroxine biosynthesis 5 2.22e-01 4.11e-01 0.45300 -0.084400 0.445000 7.44e-01 8.48e-02
RHO GTPases Activate WASPs and WAVEs 35 3.92e-05 5.48e-04 0.45300 0.194000 -0.409000 4.65e-02 2.82e-05
Maturation of spike protein 9683686 5 1.89e-01 3.76e-01 0.45300 0.272000 0.362000 2.93e-01 1.61e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 1.57e-01 3.35e-01 0.45300 0.007620 -0.452000 9.74e-01 5.49e-02
MET receptor recycling 9 7.28e-02 2.04e-01 0.45200 0.420000 -0.166000 2.91e-02 3.88e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 4.26e-02 1.43e-01 0.45000 -0.196000 0.406000 2.61e-01 1.98e-02
Mitochondrial Uncoupling 6 1.82e-01 3.68e-01 0.45000 -0.379000 0.243000 1.08e-01 3.02e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 3.52e-02 1.25e-01 0.44800 -0.351000 0.278000 3.54e-02 9.52e-02
Glycogen synthesis 11 4.77e-02 1.54e-01 0.44600 0.328000 -0.303000 5.96e-02 8.23e-02
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 7.66e-02 2.11e-01 0.44600 0.421000 -0.147000 2.86e-02 4.45e-01
Hh mutants are degraded by ERAD 42 7.91e-06 1.38e-04 0.44600 0.213000 -0.392000 1.67e-02 1.12e-05
Defective CFTR causes cystic fibrosis 47 1.91e-06 4.09e-05 0.44600 0.203000 -0.397000 1.59e-02 2.51e-06
Hedgehog ligand biogenesis 47 2.25e-06 4.65e-05 0.44600 0.260000 -0.362000 2.06e-03 1.74e-05
Uptake of dietary cobalamins into enterocytes 5 2.00e-01 3.87e-01 0.44400 -0.292000 -0.335000 2.58e-01 1.94e-01
Transcriptional regulation of granulopoiesis 44 5.47e-06 1.00e-04 0.44300 0.229000 -0.380000 8.58e-03 1.31e-05
Acetylcholine regulates insulin secretion 9 8.47e-02 2.25e-01 0.44200 -0.379000 0.227000 4.88e-02 2.38e-01
Fcgamma receptor (FCGR) dependent phagocytosis 146 5.29e-18 7.82e-16 0.44200 0.235000 -0.374000 9.19e-07 5.58e-15
TGFBR3 expression 20 1.99e-03 1.36e-02 0.44200 -0.408000 -0.170000 1.60e-03 1.87e-01
Signaling by MAPK mutants 6 1.88e-01 3.73e-01 0.44100 -0.152000 0.414000 5.20e-01 7.87e-02
Neurotoxicity of clostridium toxins 9 8.43e-02 2.24e-01 0.44100 -0.395000 0.197000 4.04e-02 3.06e-01
Creatine metabolism 6 1.63e-01 3.44e-01 0.44100 -0.434000 -0.079300 6.57e-02 7.36e-01
Glycerophospholipid catabolism 6 1.84e-01 3.68e-01 0.44000 -0.429000 0.099000 6.87e-02 6.75e-01
Noncanonical activation of NOTCH3 8 1.13e-01 2.75e-01 0.43900 0.395000 -0.193000 5.31e-02 3.45e-01
G1/S-Specific Transcription 29 2.48e-04 2.56e-03 0.43900 0.040000 -0.437000 7.09e-01 4.60e-05
Regulation of MITF-M-dependent genes involved in apoptosis 16 6.63e-03 3.48e-02 0.43900 -0.291000 -0.328000 4.38e-02 2.30e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 4.11e-02 1.39e-01 0.43800 0.325000 -0.293000 5.13e-02 7.86e-02
Signaling by the B Cell Receptor (BCR) 149 6.37e-18 8.20e-16 0.43800 0.256000 -0.355000 7.04e-08 7.15e-14
Regulation of ornithine decarboxylase (ODC) 38 3.64e-05 5.30e-04 0.43500 0.176000 -0.398000 6.07e-02 2.13e-05
Urea cycle 6 1.79e-01 3.63e-01 0.43400 0.434000 0.021800 6.59e-02 9.26e-01
Digestion and absorption 7 1.47e-01 3.23e-01 0.43300 0.425000 -0.082000 5.15e-02 7.07e-01
Antimicrobial peptides 33 1.88e-04 2.04e-03 0.43300 0.275000 -0.334000 6.17e-03 9.11e-04
Defects in biotin (Btn) metabolism 8 1.26e-01 2.92e-01 0.43000 -0.369000 0.220000 7.07e-02 2.80e-01
G beta:gamma signalling through BTK 15 2.07e-02 8.51e-02 0.42900 0.221000 -0.368000 1.39e-01 1.35e-02
Regulation of PTEN mRNA translation 12 3.23e-02 1.18e-01 0.42900 -0.084600 -0.420000 6.12e-01 1.17e-02
Keratan sulfate degradation 9 6.97e-02 1.97e-01 0.42900 0.377000 0.204000 5.03e-02 2.88e-01
Passive transport by Aquaporins 6 1.78e-01 3.63e-01 0.42800 0.414000 0.108000 7.87e-02 6.47e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.00e-03 2.80e-02 0.42800 -0.023200 -0.427000 8.61e-01 1.26e-03
Apoptosis induced DNA fragmentation 10 7.88e-02 2.15e-01 0.42800 0.326000 -0.276000 7.41e-02 1.30e-01
Initiation of Nuclear Envelope (NE) Reformation 19 7.67e-03 3.88e-02 0.42800 0.218000 -0.368000 9.97e-02 5.53e-03
Inactivation of CDC42 and RAC1 7 1.59e-01 3.37e-01 0.42700 0.408000 -0.129000 6.19e-02 5.56e-01
Lipophagy 7 1.64e-01 3.44e-01 0.42700 0.387000 -0.181000 7.64e-02 4.07e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 2.81e-01 4.75e-01 0.42600 -0.241000 0.352000 3.51e-01 1.73e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 4.63e-02 1.51e-01 0.42600 0.383000 -0.186000 2.18e-02 2.63e-01
Transport of connexons to the plasma membrane 12 4.63e-02 1.51e-01 0.42600 0.383000 -0.186000 2.18e-02 2.63e-01
Hh mutants abrogate ligand secretion 43 1.90e-05 3.18e-04 0.42500 0.220000 -0.364000 1.26e-02 3.69e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 4.60e-05 6.09e-04 0.42500 0.169000 -0.390000 6.78e-02 2.53e-05
p53-Independent DNA Damage Response 39 4.60e-05 6.09e-04 0.42500 0.169000 -0.390000 6.78e-02 2.53e-05
p53-Independent G1/S DNA damage checkpoint 39 4.60e-05 6.09e-04 0.42500 0.169000 -0.390000 6.78e-02 2.53e-05
SIRT1 negatively regulates rRNA expression 22 3.53e-03 2.18e-02 0.42100 0.408000 -0.103000 9.29e-04 4.04e-01
RHO GTPases Activate ROCKs 18 1.20e-02 5.47e-02 0.42000 0.268000 -0.324000 4.87e-02 1.74e-02
RHO GTPases Activate NADPH Oxidases 21 4.08e-03 2.44e-02 0.42000 0.045600 -0.418000 7.18e-01 9.14e-04
E2F-enabled inhibition of pre-replication complex formation 9 9.78e-02 2.50e-01 0.42000 0.077200 -0.413000 6.89e-01 3.20e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 1.05e-04 1.20e-03 0.41900 0.185000 -0.375000 5.09e-02 7.72e-05
Diseases of hemostasis 13 3.66e-02 1.29e-01 0.41800 0.406000 -0.100000 1.12e-02 5.32e-01
Disorders of Developmental Biology 12 3.37e-02 1.22e-01 0.41800 -0.359000 -0.214000 3.12e-02 1.99e-01
Disorders of Nervous System Development 12 3.37e-02 1.22e-01 0.41800 -0.359000 -0.214000 3.12e-02 1.99e-01
Loss of function of MECP2 in Rett syndrome 12 3.37e-02 1.22e-01 0.41800 -0.359000 -0.214000 3.12e-02 1.99e-01
Pervasive developmental disorders 12 3.37e-02 1.22e-01 0.41800 -0.359000 -0.214000 3.12e-02 1.99e-01
Complement cascade 99 3.86e-11 1.58e-09 0.41700 0.350000 -0.226000 1.74e-09 1.00e-04
Vif-mediated degradation of APOBEC3G 41 4.35e-05 5.97e-04 0.41600 0.182000 -0.374000 4.35e-02 3.33e-05
Synthesis of PE 12 3.39e-02 1.22e-01 0.41600 0.306000 0.282000 6.64e-02 9.08e-02
Intrinsic Pathway of Fibrin Clot Formation 15 2.75e-02 1.06e-01 0.41600 0.295000 -0.293000 4.82e-02 4.95e-02
Acetylcholine binding and downstream events 5 2.83e-01 4.77e-01 0.41500 0.076400 -0.408000 7.67e-01 1.14e-01
Postsynaptic nicotinic acetylcholine receptors 5 2.83e-01 4.77e-01 0.41500 0.076400 -0.408000 7.67e-01 1.14e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 1.52e-01 3.32e-01 0.41500 -0.404000 -0.093700 6.41e-02 6.68e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 2.39e-01 4.26e-01 0.41400 -0.293000 0.293000 2.14e-01 2.14e-01
Amyloid fiber formation 51 3.08e-06 5.98e-05 0.41400 0.402000 -0.098600 6.69e-07 2.23e-01
CS/DS degradation 9 1.01e-01 2.56e-01 0.41300 -0.032300 0.412000 8.67e-01 3.23e-02
RHOT2 GTPase cycle 7 1.77e-01 3.62e-01 0.41200 0.401000 -0.097800 6.64e-02 6.54e-01
Fc epsilon receptor (FCERI) signaling 178 5.91e-19 1.03e-16 0.41200 0.239000 -0.336000 3.77e-08 1.00e-14
Cyclin A/B1/B2 associated events during G2/M transition 25 2.40e-03 1.61e-02 0.41200 0.154000 -0.382000 1.83e-01 9.52e-04
EPHB-mediated forward signaling 38 1.06e-04 1.20e-03 0.41000 0.131000 -0.388000 1.64e-01 3.42e-05
Regulation of Apoptosis 40 7.76e-05 9.31e-04 0.40900 0.182000 -0.367000 4.64e-02 5.95e-05
TNFR1-mediated ceramide production 6 2.23e-01 4.12e-01 0.40900 -0.408000 0.024300 8.32e-02 9.18e-01
Condensation of Prophase Chromosomes 27 1.94e-03 1.33e-02 0.40800 0.289000 -0.289000 9.42e-03 9.37e-03
Synthesis of diphthamide-EEF2 8 1.25e-01 2.90e-01 0.40700 0.105000 0.393000 6.06e-01 5.40e-02
Triglyceride catabolism 15 2.81e-02 1.08e-01 0.40700 0.128000 -0.386000 3.89e-01 9.57e-03
MECP2 regulates neuronal receptors and channels 13 3.23e-02 1.18e-01 0.40700 -0.157000 -0.376000 3.28e-01 1.90e-02
Cross-presentation of soluble exogenous antigens (endosomes) 35 2.58e-04 2.63e-03 0.40700 0.143000 -0.381000 1.43e-01 9.74e-05
MAPK1 (ERK2) activation 8 1.49e-01 3.27e-01 0.40600 0.119000 -0.388000 5.60e-01 5.72e-02
Signaling by CSF1 (M-CSF) in myeloid cells 30 4.83e-04 4.17e-03 0.40500 -0.075700 -0.398000 4.73e-01 1.62e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 6.53e-02 1.88e-01 0.40500 0.285000 -0.288000 8.75e-02 8.46e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 7.18e-05 8.79e-04 0.40400 0.141000 -0.378000 1.18e-01 2.77e-05
LGI-ADAM interactions 9 1.25e-01 2.91e-01 0.40300 -0.371000 0.157000 5.38e-02 4.15e-01
Molybdenum cofactor biosynthesis 6 2.23e-01 4.12e-01 0.40200 -0.398000 -0.057900 9.12e-02 8.06e-01
Leading Strand Synthesis 14 3.81e-02 1.32e-01 0.40200 -0.385000 0.115000 1.25e-02 4.55e-01
Polymerase switching 14 3.81e-02 1.32e-01 0.40200 -0.385000 0.115000 1.25e-02 4.55e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 6.16e-02 1.82e-01 0.40200 0.102000 0.389000 5.57e-01 2.56e-02
Negative regulation of MET activity 18 1.71e-02 7.28e-02 0.40200 0.216000 -0.339000 1.12e-01 1.29e-02
Regulation of MECP2 expression and activity 28 6.40e-04 5.23e-03 0.40200 -0.291000 -0.277000 7.78e-03 1.11e-02
Recycling of bile acids and salts 8 1.27e-01 2.94e-01 0.40100 -0.361000 -0.173000 7.68e-02 3.95e-01
Platelet degranulation 104 9.19e-11 3.60e-09 0.40000 0.317000 -0.244000 2.21e-08 1.75e-05
Signaling by LTK in cancer 7 1.95e-01 3.83e-01 0.40000 0.083800 -0.391000 7.01e-01 7.32e-02
Degradation of GLI2 by the proteasome 45 3.82e-05 5.39e-04 0.39900 0.156000 -0.367000 6.98e-02 2.02e-05
GLI3 is processed to GLI3R by the proteasome 45 3.82e-05 5.39e-04 0.39900 0.156000 -0.367000 6.98e-02 2.02e-05
PINK1-PRKN Mediated Mitophagy 31 9.77e-04 7.39e-03 0.39800 0.354000 -0.182000 6.38e-04 7.98e-02
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 2.05e-01 3.91e-01 0.39800 -0.373000 0.140000 8.78e-02 5.22e-01
APOBEC3G mediated resistance to HIV-1 infection 5 3.00e-01 4.94e-01 0.39800 -0.397000 -0.022600 1.24e-01 9.30e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 2.78e-01 4.72e-01 0.39800 -0.213000 -0.336000 4.09e-01 1.94e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 2.78e-01 4.72e-01 0.39800 -0.213000 -0.336000 4.09e-01 1.94e-01
Apoptotic cleavage of cellular proteins 35 4.23e-04 3.73e-03 0.39600 0.168000 -0.359000 8.55e-02 2.40e-04
DARPP-32 events 22 8.00e-03 4.00e-02 0.39500 0.182000 -0.350000 1.38e-01 4.49e-03
Sodium/Proton exchangers 7 1.71e-01 3.53e-01 0.39400 -0.230000 -0.320000 2.91e-01 1.43e-01
Regulation of RAS by GAPs 55 6.21e-06 1.12e-04 0.39300 0.180000 -0.350000 2.08e-02 7.19e-06
Caspase activation via Dependence Receptors in the absence of ligand 9 1.21e-01 2.88e-01 0.39300 -0.010900 -0.393000 9.55e-01 4.12e-02
CHL1 interactions 8 1.79e-01 3.63e-01 0.39300 0.252000 -0.302000 2.17e-01 1.39e-01
CDH11 homotypic and heterotypic interactions 5 3.35e-01 5.29e-01 0.39300 -0.354000 0.170000 1.70e-01 5.12e-01
Apoptotic execution phase 46 4.94e-05 6.46e-04 0.39200 0.206000 -0.334000 1.57e-02 8.81e-05
Response to elevated platelet cytosolic Ca2+ 108 1.01e-10 3.87e-09 0.39200 0.301000 -0.251000 6.39e-08 6.32e-06
Cytochrome c-mediated apoptotic response 13 5.47e-02 1.69e-01 0.39200 0.088600 -0.382000 5.80e-01 1.72e-02
RHO GTPases activate PAKs 20 1.38e-02 6.09e-02 0.39200 0.219000 -0.325000 8.97e-02 1.19e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 9 1.07e-01 2.66e-01 0.39200 -0.215000 -0.327000 2.63e-01 8.92e-02
RUNX1 regulates estrogen receptor mediated transcription 6 2.33e-01 4.20e-01 0.39100 -0.126000 -0.371000 5.92e-01 1.16e-01
Signaling by activated point mutants of FGFR1 5 2.90e-01 4.86e-01 0.39000 0.321000 0.222000 2.14e-01 3.89e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 3.57e-06 6.79e-05 0.39000 0.213000 -0.327000 4.73e-03 1.37e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 1.14e-04 1.28e-03 0.39000 0.151000 -0.359000 8.96e-02 5.54e-05
APC/C:Cdc20 mediated degradation of mitotic proteins 63 1.49e-06 3.24e-05 0.39000 0.193000 -0.339000 8.18e-03 3.30e-06
Formation of the nephric duct 8 1.65e-01 3.45e-01 0.39000 0.043300 -0.387000 8.32e-01 5.78e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 1.19e-06 2.69e-05 0.38900 0.185000 -0.343000 1.05e-02 2.10e-06
PDH complex synthesizes acetyl-CoA from PYR 5 3.45e-01 5.41e-01 0.38900 0.194000 -0.338000 4.53e-01 1.91e-01
Activation of NOXA and translocation to mitochondria 5 3.01e-01 4.95e-01 0.38900 -0.366000 -0.131000 1.56e-01 6.13e-01
Defective HLCS causes multiple carboxylase deficiency 7 2.29e-01 4.17e-01 0.38800 -0.319000 0.222000 1.44e-01 3.09e-01
Pentose phosphate pathway 13 6.62e-02 1.90e-01 0.38800 0.247000 -0.299000 1.23e-01 6.21e-02
N-glycan antennae elongation in the medial/trans-Golgi 20 1.47e-02 6.37e-02 0.38700 0.180000 -0.343000 1.64e-01 7.96e-03
Negative regulation of NOTCH4 signaling 44 8.11e-05 9.62e-04 0.38700 0.132000 -0.364000 1.29e-01 2.99e-05
Cell surface interactions at the vascular wall 169 7.31e-16 6.11e-14 0.38600 0.246000 -0.298000 3.40e-08 2.36e-11
Alternative complement activation 5 3.33e-01 5.27e-01 0.38600 -0.382000 0.056400 1.39e-01 8.27e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 3.65e-02 1.29e-01 0.38600 0.281000 -0.264000 5.13e-02 6.73e-02
ABC transporter disorders 59 4.55e-06 8.56e-05 0.38600 0.196000 -0.332000 9.26e-03 1.00e-05
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 4.57e-05 6.09e-04 0.38600 0.201000 -0.329000 1.60e-02 7.93e-05
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 7.03e-04 5.60e-03 0.38600 -0.385000 -0.027900 1.65e-04 7.85e-01
Insulin receptor recycling 24 6.51e-03 3.44e-02 0.38500 0.347000 -0.168000 3.26e-03 1.55e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 6.53e-07 1.53e-05 0.38500 0.210000 -0.322000 2.61e-03 3.60e-06
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 8.86e-03 4.28e-02 0.38500 0.294000 -0.247000 1.45e-02 4.00e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 1.81e-05 3.05e-04 0.38400 0.148000 -0.355000 6.45e-02 9.60e-06
Phase 3 - rapid repolarisation 6 2.36e-01 4.23e-01 0.38400 -0.249000 -0.292000 2.90e-01 2.15e-01
Prostanoid ligand receptors 8 1.94e-01 3.82e-01 0.38300 0.313000 -0.220000 1.25e-01 2.80e-01
Killing mechanisms 9 1.57e-01 3.35e-01 0.38300 -0.190000 0.332000 3.23e-01 8.43e-02
WNT5:FZD7-mediated leishmania damping 9 1.57e-01 3.35e-01 0.38300 -0.190000 0.332000 3.23e-01 8.43e-02
Interleukin-1 processing 8 1.97e-01 3.85e-01 0.38200 -0.288000 0.251000 1.58e-01 2.18e-01
Degradation of GLI1 by the proteasome 46 7.57e-05 9.15e-04 0.38200 0.170000 -0.343000 4.66e-02 5.78e-05
Maturation of spike protein 9694548 35 8.24e-04 6.43e-03 0.38200 0.231000 -0.304000 1.81e-02 1.84e-03
Post-chaperonin tubulin folding pathway 18 2.49e-02 9.77e-02 0.38100 0.342000 -0.169000 1.20e-02 2.16e-01
EGFR Transactivation by Gastrin 7 2.00e-01 3.87e-01 0.38100 -0.131000 -0.357000 5.47e-01 1.02e-01
Anchoring fibril formation 7 1.92e-01 3.80e-01 0.38000 0.245000 0.291000 2.61e-01 1.83e-01
Synthesis of PIPs at the Golgi membrane 16 3.98e-02 1.36e-01 0.38000 -0.311000 0.218000 3.12e-02 1.31e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 2.91e-03 1.88e-02 0.37900 0.202000 -0.321000 5.99e-02 2.75e-03
Physiological factors 9 1.63e-01 3.43e-01 0.37900 0.331000 -0.184000 8.55e-02 3.40e-01
RUNX1 regulates transcription of genes involved in WNT signaling 5 3.67e-01 5.58e-01 0.37800 0.194000 -0.325000 4.53e-01 2.09e-01
Golgi-to-ER retrograde transport 123 1.98e-11 8.44e-10 0.37800 0.174000 -0.336000 8.87e-04 1.28e-10
Smooth Muscle Contraction 34 1.20e-03 8.90e-03 0.37800 0.268000 -0.266000 6.88e-03 7.24e-03
cGMP effects 12 6.86e-02 1.94e-01 0.37700 0.099200 0.364000 5.52e-01 2.91e-02
RUNX2 regulates genes involved in cell migration 6 2.83e-01 4.77e-01 0.37700 -0.044900 0.374000 8.49e-01 1.12e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 2.09e-01 3.95e-01 0.37700 -0.361000 -0.108000 9.78e-02 6.22e-01
Ubiquitin-dependent degradation of Cyclin D 39 3.75e-04 3.41e-03 0.37700 0.142000 -0.349000 1.26e-01 1.59e-04
Generation of second messenger molecules 38 3.30e-04 3.10e-03 0.37700 -0.375000 0.030200 6.22e-05 7.47e-01
Phase 4 - resting membrane potential 9 1.28e-01 2.96e-01 0.37700 -0.181000 -0.330000 3.46e-01 8.65e-02
MAPK3 (ERK1) activation 9 1.66e-01 3.46e-01 0.37600 0.172000 -0.334000 3.71e-01 8.23e-02
2-LTR circle formation 7 1.99e-01 3.87e-01 0.37600 -0.281000 -0.250000 1.98e-01 2.52e-01
Kidney development 16 3.98e-02 1.36e-01 0.37600 0.135000 -0.351000 3.49e-01 1.52e-02
GABA synthesis, release, reuptake and degradation 12 7.47e-02 2.07e-01 0.37600 -0.374000 -0.035500 2.49e-02 8.31e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 1.77e-03 1.23e-02 0.37600 0.185000 -0.327000 6.97e-02 1.38e-03
Spry regulation of FGF signaling 16 4.36e-02 1.45e-01 0.37400 0.313000 -0.206000 3.03e-02 1.55e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 5.57e-02 1.70e-01 0.37400 0.054500 -0.370000 7.24e-01 1.65e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 2.75e-04 2.77e-03 0.37300 0.186000 -0.323000 3.73e-02 2.86e-04
Somitogenesis 41 2.78e-04 2.78e-03 0.37300 0.111000 -0.356000 2.19e-01 8.12e-05
PTK6 Regulates Cell Cycle 6 2.76e-01 4.70e-01 0.37300 -0.368000 -0.056100 1.18e-01 8.12e-01
Ethanol oxidation 6 3.00e-01 4.94e-01 0.37200 -0.100000 0.359000 6.71e-01 1.28e-01
Signaling by FLT3 fusion proteins 18 1.79e-02 7.57e-02 0.37200 -0.194000 -0.317000 1.55e-01 1.97e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 7.58e-06 1.34e-04 0.37100 0.189000 -0.320000 1.07e-02 1.55e-05
Deposition of new CENPA-containing nucleosomes at the centromere 37 8.71e-04 6.64e-03 0.37000 0.299000 -0.218000 1.67e-03 2.17e-02
Nucleosome assembly 37 8.71e-04 6.64e-03 0.37000 0.299000 -0.218000 1.67e-03 2.17e-02
Mitochondrial unfolded protein response (UPRmt) 17 3.82e-02 1.32e-01 0.37000 -0.179000 0.323000 2.02e-01 2.10e-02
CD28 dependent Vav1 pathway 12 7.10e-02 1.99e-01 0.36900 -0.189000 -0.317000 2.56e-01 5.72e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 1.03e-01 2.60e-01 0.36900 0.368000 0.014000 3.44e-02 9.36e-01
Assembly of active LPL and LIPC lipase complexes 10 1.36e-01 3.06e-01 0.36800 0.364000 -0.049600 4.60e-02 7.86e-01
Interaction between L1 and Ankyrins 25 5.66e-03 3.12e-02 0.36700 -0.044000 -0.364000 7.03e-01 1.61e-03
Autodegradation of the E3 ubiquitin ligase COP1 38 6.89e-04 5.53e-03 0.36600 0.127000 -0.344000 1.77e-01 2.47e-04
Glutathione synthesis and recycling 10 1.14e-01 2.77e-01 0.36600 -0.220000 -0.292000 2.29e-01 1.09e-01
Beta-catenin phosphorylation cascade 17 4.15e-02 1.39e-01 0.36600 0.196000 -0.309000 1.63e-01 2.74e-02
Mucopolysaccharidoses 11 9.51e-02 2.44e-01 0.36500 0.154000 0.331000 3.75e-01 5.71e-02
SCF-beta-TrCP mediated degradation of Emi1 42 3.33e-04 3.12e-03 0.36500 0.126000 -0.343000 1.59e-01 1.20e-04
RHOBTB1 GTPase cycle 23 1.38e-02 6.09e-02 0.36400 0.183000 -0.315000 1.28e-01 8.94e-03
Cellular hexose transport 14 6.93e-02 1.96e-01 0.36400 -0.349000 0.103000 2.39e-02 5.04e-01
Nuclear events stimulated by ALK signaling in cancer 33 8.59e-04 6.64e-03 0.36300 -0.220000 -0.289000 2.89e-02 4.07e-03
HDR through MMEJ (alt-NHEJ) 12 8.00e-02 2.17e-01 0.36300 -0.332000 -0.146000 4.62e-02 3.82e-01
G beta:gamma signalling through CDC42 17 4.02e-02 1.37e-01 0.36300 0.115000 -0.344000 4.13e-01 1.40e-02
RHO GTPases activate CIT 18 3.48e-02 1.25e-01 0.36200 0.144000 -0.333000 2.90e-01 1.46e-02
Reversible hydration of carbon dioxide 8 1.81e-01 3.66e-01 0.36200 0.214000 0.292000 2.94e-01 1.52e-01
Activation of G protein gated Potassium channels 18 3.74e-02 1.30e-01 0.36200 0.214000 -0.292000 1.16e-01 3.19e-02
G protein gated Potassium channels 18 3.74e-02 1.30e-01 0.36200 0.214000 -0.292000 1.16e-01 3.19e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 3.74e-02 1.30e-01 0.36200 0.214000 -0.292000 1.16e-01 3.19e-02
Degradation of cysteine and homocysteine 12 1.10e-01 2.71e-01 0.36200 -0.182000 0.313000 2.76e-01 6.05e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 1.71e-05 2.91e-04 0.36100 0.179000 -0.314000 1.63e-02 2.66e-05
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 3.10e-02 1.16e-01 0.36100 -0.090400 -0.350000 5.19e-01 1.26e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 3.10e-02 1.16e-01 0.36100 -0.090400 -0.350000 5.19e-01 1.26e-02
Regulated proteolysis of p75NTR 11 1.22e-01 2.89e-01 0.36000 0.357000 -0.044800 4.04e-02 7.97e-01
Gain-of-function MRAS complexes activate RAF signaling 8 1.99e-01 3.86e-01 0.35900 -0.088400 -0.348000 6.65e-01 8.83e-02
SHOC2 M1731 mutant abolishes MRAS complex function 8 1.99e-01 3.86e-01 0.35900 -0.088400 -0.348000 6.65e-01 8.83e-02
Signaling by MRAS-complex mutants 8 1.99e-01 3.86e-01 0.35900 -0.088400 -0.348000 6.65e-01 8.83e-02
Cargo concentration in the ER 31 2.68e-03 1.75e-02 0.35900 0.036000 -0.357000 7.29e-01 5.80e-04
Translation of Structural Proteins 9694635 55 5.30e-05 6.79e-04 0.35900 0.214000 -0.288000 5.93e-03 2.25e-04
tRNA modification in the mitochondrion 9 1.65e-01 3.45e-01 0.35900 0.072100 0.351000 7.08e-01 6.80e-02
Vpu mediated degradation of CD4 39 8.07e-04 6.33e-03 0.35700 0.123000 -0.336000 1.84e-01 2.86e-04
Activation of AMPK downstream of NMDARs 20 2.84e-02 1.09e-01 0.35700 0.296000 -0.200000 2.21e-02 1.21e-01
Interleukin-15 signaling 14 5.63e-02 1.71e-01 0.35600 -0.196000 -0.297000 2.03e-01 5.42e-02
Orc1 removal from chromatin 58 2.58e-05 3.99e-04 0.35600 0.109000 -0.339000 1.51e-01 7.91e-06
N-glycan trimming and elongation in the cis-Golgi 5 3.97e-01 5.86e-01 0.35600 0.080100 -0.347000 7.57e-01 1.79e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.00e-02 4.75e-02 0.35500 -0.347000 0.074200 2.64e-03 5.21e-01
Norepinephrine Neurotransmitter Release Cycle 14 8.67e-02 2.28e-01 0.35400 -0.218000 0.279000 1.58e-01 7.03e-02
Termination of O-glycan biosynthesis 15 5.45e-02 1.68e-01 0.35400 -0.058100 -0.349000 6.97e-01 1.92e-02
Activated NTRK2 signals through FRS2 and FRS3 8 2.41e-01 4.27e-01 0.35400 0.138000 -0.325000 4.98e-01 1.11e-01
Degradation of DVL 43 5.12e-04 4.39e-03 0.35400 0.162000 -0.314000 6.55e-02 3.63e-04
Suppression of apoptosis 7 2.74e-01 4.69e-01 0.35300 0.351000 -0.044700 1.08e-01 8.38e-01
Metabolism of polyamines 46 3.16e-04 3.00e-03 0.35300 0.171000 -0.309000 4.43e-02 2.90e-04
APC truncation mutants have impaired AXIN binding 14 8.35e-02 2.23e-01 0.35300 0.135000 -0.326000 3.81e-01 3.46e-02
AXIN missense mutants destabilize the destruction complex 14 8.35e-02 2.23e-01 0.35300 0.135000 -0.326000 3.81e-01 3.46e-02
Signaling by AMER1 mutants 14 8.35e-02 2.23e-01 0.35300 0.135000 -0.326000 3.81e-01 3.46e-02
Signaling by APC mutants 14 8.35e-02 2.23e-01 0.35300 0.135000 -0.326000 3.81e-01 3.46e-02
Signaling by AXIN mutants 14 8.35e-02 2.23e-01 0.35300 0.135000 -0.326000 3.81e-01 3.46e-02
Truncations of AMER1 destabilize the destruction complex 14 8.35e-02 2.23e-01 0.35300 0.135000 -0.326000 3.81e-01 3.46e-02
Apoptotic cleavage of cell adhesion proteins 8 2.50e-01 4.38e-01 0.35300 0.219000 -0.277000 2.85e-01 1.75e-01
Advanced glycosylation endproduct receptor signaling 12 1.24e-01 2.90e-01 0.35300 0.291000 -0.199000 8.09e-02 2.32e-01
CDC6 association with the ORC:origin complex 8 2.15e-01 4.03e-01 0.35300 -0.053900 -0.349000 7.92e-01 8.77e-02
Signaling by CSF3 (G-CSF) 29 4.81e-03 2.73e-02 0.35300 0.040700 -0.350000 7.05e-01 1.09e-03
Branched-chain ketoacid dehydrogenase kinase deficiency 5 3.85e-01 5.74e-01 0.35300 0.350000 0.040200 1.75e-01 8.76e-01
Zygotic genome activation (ZGA) 5 4.15e-01 5.98e-01 0.35200 -0.148000 0.320000 5.66e-01 2.16e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 3.67e-01 5.58e-01 0.35100 -0.209000 -0.282000 4.18e-01 2.74e-01
Nephrin family interactions 19 3.44e-02 1.24e-01 0.35100 0.110000 -0.334000 4.08e-01 1.18e-02
Platelet Aggregation (Plug Formation) 28 6.55e-03 3.45e-02 0.35100 0.343000 -0.071800 1.66e-03 5.11e-01
RHOBTB GTPase Cycle 35 2.32e-03 1.57e-02 0.35100 0.160000 -0.312000 1.02e-01 1.40e-03
P2Y receptors 10 1.39e-01 3.10e-01 0.35000 -0.166000 -0.308000 3.64e-01 9.12e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.27e-02 1.84e-01 0.34900 -0.278000 -0.210000 7.14e-02 1.73e-01
Regulation of CDH11 Expression and Function 22 1.44e-02 6.29e-02 0.34900 -0.329000 -0.116000 7.59e-03 3.44e-01
MAPK6/MAPK4 signaling 69 5.24e-06 9.68e-05 0.34900 0.084100 -0.338000 2.27e-01 1.16e-06
Activation of the phototransduction cascade 8 2.43e-01 4.30e-01 0.34800 0.339000 -0.078700 9.64e-02 7.00e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 4.60e-02 1.50e-01 0.34800 -0.159000 0.310000 2.42e-01 2.29e-02
Activation of C3 and C5 7 2.73e-01 4.68e-01 0.34800 0.034100 0.346000 8.76e-01 1.13e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 3.46e-01 5.41e-01 0.34700 -0.066400 0.341000 7.78e-01 1.48e-01
Negative feedback regulation of MAPK pathway 6 3.29e-01 5.23e-01 0.34700 0.345000 0.039600 1.43e-01 8.66e-01
Pyrimidine catabolism 9 2.18e-01 4.07e-01 0.34700 0.176000 -0.299000 3.60e-01 1.20e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 3.15e-01 5.10e-01 0.34700 0.141000 0.317000 5.49e-01 1.79e-01
p75NTR negatively regulates cell cycle via SC1 5 3.99e-01 5.88e-01 0.34700 -0.028600 -0.345000 9.12e-01 1.81e-01
Sphingolipid de novo biosynthesis 34 3.55e-03 2.19e-02 0.34500 0.289000 -0.188000 3.54e-03 5.83e-02
SCF(Skp2)-mediated degradation of p27/p21 50 2.04e-04 2.20e-03 0.34400 0.109000 -0.326000 1.81e-01 6.50e-05
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 3.16e-01 5.10e-01 0.34400 0.218000 -0.266000 3.18e-01 2.23e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.10e-02 1.16e-01 0.34400 0.289000 -0.187000 2.19e-02 1.39e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.84e-01 3.68e-01 0.34400 0.325000 -0.111000 7.50e-02 5.42e-01
NrCAM interactions 6 3.65e-01 5.57e-01 0.34200 -0.322000 0.117000 1.72e-01 6.21e-01
Nef and signal transduction 8 2.37e-01 4.23e-01 0.34200 -0.041500 -0.339000 8.39e-01 9.65e-02
Organic anion transporters 7 3.02e-01 4.96e-01 0.34200 -0.336000 0.063000 1.24e-01 7.73e-01
Glycogen breakdown (glycogenolysis) 12 1.38e-01 3.10e-01 0.34200 0.306000 -0.153000 6.68e-02 3.60e-01
RHOBTB2 GTPase cycle 23 2.02e-02 8.33e-02 0.34100 0.072900 -0.333000 5.45e-01 5.65e-03
Cleavage of the damaged purine 21 3.12e-02 1.16e-01 0.34100 0.313000 -0.136000 1.31e-02 2.79e-01
Depurination 21 3.12e-02 1.16e-01 0.34100 0.313000 -0.136000 1.31e-02 2.79e-01
Recognition and association of DNA glycosylase with site containing an affected purine 21 3.12e-02 1.16e-01 0.34100 0.313000 -0.136000 1.31e-02 2.79e-01
COPI-mediated anterograde transport 92 3.18e-07 8.16e-06 0.34100 0.170000 -0.296000 4.88e-03 9.60e-07
Late SARS-CoV-2 Infection Events 63 3.71e-05 5.34e-04 0.34100 0.188000 -0.284000 9.95e-03 9.48e-05
Interleukin receptor SHC signaling 23 1.42e-02 6.24e-02 0.34100 -0.132000 -0.314000 2.73e-01 9.15e-03
TICAM1, RIP1-mediated IKK complex recruitment 19 4.34e-02 1.44e-01 0.34000 0.127000 -0.316000 3.38e-01 1.71e-02
Uptake and function of anthrax toxins 10 1.95e-01 3.83e-01 0.34000 0.154000 -0.303000 4.00e-01 9.66e-02
Regulation of Expression and Function of Type II Classical Cadherins 23 1.59e-02 6.86e-02 0.34000 -0.332000 -0.073000 5.85e-03 5.45e-01
Regulation of Homotypic Cell-Cell Adhesion 23 1.59e-02 6.86e-02 0.34000 -0.332000 -0.073000 5.85e-03 5.45e-01
PCNA-Dependent Long Patch Base Excision Repair 21 2.94e-02 1.12e-01 0.34000 -0.331000 0.077300 8.68e-03 5.40e-01
Interleukin-35 Signalling 12 1.45e-01 3.21e-01 0.34000 0.199000 -0.275000 2.32e-01 9.92e-02
Insulin processing 18 4.05e-02 1.38e-01 0.33900 -0.054400 -0.335000 6.90e-01 1.39e-02
Regulation of TLR by endogenous ligand 15 6.03e-02 1.80e-01 0.33900 -0.226000 -0.252000 1.29e-01 9.06e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 8.04e-03 4.01e-02 0.33900 0.182000 -0.286000 8.41e-02 6.71e-03
Sema4D mediated inhibition of cell attachment and migration 7 2.73e-01 4.67e-01 0.33800 0.220000 0.256000 3.12e-01 2.41e-01
Erythrocytes take up carbon dioxide and release oxygen 11 1.75e-01 3.59e-01 0.33700 0.277000 -0.192000 1.11e-01 2.71e-01
O2/CO2 exchange in erythrocytes 11 1.75e-01 3.59e-01 0.33700 0.277000 -0.192000 1.11e-01 2.71e-01
Glycogen metabolism 21 3.51e-02 1.25e-01 0.33700 0.293000 -0.167000 2.02e-02 1.86e-01
Gamma-carboxylation of protein precursors 6 3.45e-01 5.41e-01 0.33700 -0.077800 -0.328000 7.41e-01 1.64e-01
NF-kB is activated and signals survival 12 1.12e-01 2.74e-01 0.33700 0.164000 0.294000 3.27e-01 7.75e-02
Regulation of KIT signaling 15 7.06e-02 1.98e-01 0.33600 -0.078300 -0.327000 5.99e-01 2.83e-02
PP2A-mediated dephosphorylation of key metabolic factors 7 3.12e-01 5.06e-01 0.33600 0.042200 -0.333000 8.47e-01 1.27e-01
Degradation of beta-catenin by the destruction complex 72 9.18e-06 1.59e-04 0.33500 0.106000 -0.318000 1.21e-01 3.02e-06
Leishmania infection 209 8.47e-15 5.42e-13 0.33500 0.198000 -0.270000 7.99e-07 1.69e-11
Parasitic Infection Pathways 209 8.47e-15 5.42e-13 0.33500 0.198000 -0.270000 7.99e-07 1.69e-11
SARS-CoV-2 modulates autophagy 11 1.83e-01 3.68e-01 0.33300 -0.266000 0.200000 1.27e-01 2.50e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 7.00e-05 8.62e-04 0.33200 0.178000 -0.281000 1.52e-02 1.33e-04
Signalling to ERKs 32 7.11e-03 3.65e-02 0.33200 0.175000 -0.282000 8.60e-02 5.70e-03
Resolution of Abasic Sites (AP sites) 38 2.68e-03 1.75e-02 0.33100 -0.303000 0.134000 1.22e-03 1.53e-01
Cation-coupled Chloride cotransporters 6 3.78e-01 5.67e-01 0.33100 -0.328000 0.047400 1.64e-01 8.41e-01
Attachment of GPI anchor to uPAR 7 2.96e-01 4.90e-01 0.33100 -0.311000 -0.113000 1.54e-01 6.05e-01
Degradation of AXIN 42 1.44e-03 1.04e-02 0.33100 0.124000 -0.307000 1.66e-01 5.76e-04
Maturation of nucleoprotein 9694631 15 1.01e-01 2.56e-01 0.33100 0.189000 -0.272000 2.06e-01 6.85e-02
Xenobiotics 9 2.32e-01 4.19e-01 0.33100 -0.329000 0.033800 8.75e-02 8.61e-01
Cleavage of the damaged pyrimidine 26 1.87e-02 7.83e-02 0.33100 0.280000 -0.176000 1.35e-02 1.21e-01
Depyrimidination 26 1.87e-02 7.83e-02 0.33100 0.280000 -0.176000 1.35e-02 1.21e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 1.87e-02 7.83e-02 0.33100 0.280000 -0.176000 1.35e-02 1.21e-01
Sema4D induced cell migration and growth-cone collapse 19 4.82e-02 1.55e-01 0.33000 0.324000 -0.064600 1.45e-02 6.26e-01
Glycosphingolipid transport 7 3.29e-01 5.23e-01 0.33000 -0.322000 0.068900 1.40e-01 7.52e-01
BBSome-mediated cargo-targeting to cilium 22 2.32e-02 9.32e-02 0.33000 -0.315000 -0.095400 1.04e-02 4.39e-01
Signaling by ALK 24 1.46e-02 6.35e-02 0.32900 -0.257000 -0.206000 2.93e-02 8.12e-02
PI-3K cascade:FGFR3 10 2.22e-01 4.10e-01 0.32900 0.262000 -0.199000 1.52e-01 2.75e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 1.10e-06 2.52e-05 0.32900 0.145000 -0.295000 1.73e-02 1.29e-06
Dectin-2 family 18 5.99e-02 1.80e-01 0.32800 0.079700 -0.318000 5.58e-01 1.93e-02
CLEC7A/inflammasome pathway 6 4.06e-01 5.93e-01 0.32800 -0.194000 0.265000 4.11e-01 2.61e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 1.64e-01 3.44e-01 0.32800 -0.327000 -0.024700 6.02e-02 8.87e-01
Regulation of PTEN stability and activity 55 2.88e-04 2.85e-03 0.32600 0.173000 -0.276000 2.69e-02 3.95e-04
Serine biosynthesis 8 2.90e-01 4.86e-01 0.32600 0.068300 -0.318000 7.38e-01 1.19e-01
Mitophagy 38 3.41e-03 2.14e-02 0.32500 0.295000 -0.138000 1.68e-03 1.42e-01
VxPx cargo-targeting to cilium 19 5.50e-02 1.69e-01 0.32500 0.087400 -0.313000 5.09e-01 1.82e-02
Organic cation transport 8 2.74e-01 4.69e-01 0.32500 0.323000 0.032400 1.13e-01 8.74e-01
Organic cation/anion/zwitterion transport 8 2.74e-01 4.69e-01 0.32500 0.323000 0.032400 1.13e-01 8.74e-01
Prostacyclin signalling through prostacyclin receptor 16 9.46e-02 2.44e-01 0.32500 0.179000 -0.271000 2.16e-01 6.03e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 8.68e-04 6.64e-03 0.32500 -0.018700 -0.324000 8.30e-01 2.00e-04
Cellular response to hypoxia 59 1.53e-04 1.69e-03 0.32400 0.130000 -0.297000 8.33e-02 8.02e-05
Infection with Mycobacterium tuberculosis 26 2.16e-02 8.87e-02 0.32400 0.284000 -0.156000 1.22e-02 1.70e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.19e-02 8.93e-02 0.32400 -0.018100 -0.323000 8.78e-01 6.14e-03
Stabilization of p53 43 1.66e-03 1.17e-02 0.32300 0.118000 -0.301000 1.82e-01 6.37e-04
Transport to the Golgi and subsequent modification 170 1.30e-11 5.82e-10 0.32300 0.124000 -0.298000 5.30e-03 1.95e-11
Interleukin-27 signaling 11 2.03e-01 3.91e-01 0.32300 0.211000 -0.244000 2.25e-01 1.61e-01
Proteasome assembly 50 5.35e-04 4.53e-03 0.32300 0.082700 -0.312000 3.12e-01 1.36e-04
Inhibition of DNA recombination at telomere 33 8.38e-03 4.12e-02 0.32200 0.264000 -0.185000 8.70e-03 6.55e-02
Resolution of Sister Chromatid Cohesion 115 5.06e-08 1.41e-06 0.32200 0.139000 -0.290000 9.86e-03 7.47e-08
Regulation of APC/C activators between G1/S and early anaphase 68 4.71e-05 6.19e-04 0.32200 0.134000 -0.293000 5.58e-02 3.00e-05
RHO GTPase Effectors 257 8.83e-17 7.71e-15 0.32200 0.161000 -0.278000 8.32e-06 1.55e-14
Gap junction assembly 16 1.01e-01 2.56e-01 0.32100 0.224000 -0.230000 1.21e-01 1.11e-01
Prolactin receptor signaling 11 1.59e-01 3.37e-01 0.32100 -0.208000 -0.244000 2.32e-01 1.61e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 6.34e-04 5.21e-03 0.32100 0.154000 -0.281000 5.76e-02 5.09e-04
Activation of NF-kappaB in B cells 54 4.19e-04 3.73e-03 0.32000 0.149000 -0.283000 5.75e-02 3.22e-04
NRIF signals cell death from the nucleus 15 9.82e-02 2.50e-01 0.32000 0.320000 0.004320 3.20e-02 9.77e-01
Negative regulation of FGFR3 signaling 21 4.90e-02 1.57e-01 0.31900 0.282000 -0.151000 2.54e-02 2.32e-01
PECAM1 interactions 12 1.56e-01 3.35e-01 0.31900 -0.017400 -0.319000 9.17e-01 5.60e-02
Activation of RAC1 11 1.79e-01 3.63e-01 0.31900 -0.039200 -0.316000 8.22e-01 6.91e-02
RAS signaling downstream of NF1 loss-of-function variants 7 3.52e-01 5.47e-01 0.31900 0.056500 -0.314000 7.96e-01 1.51e-01
APC/C-mediated degradation of cell cycle proteins 75 2.15e-05 3.35e-04 0.31900 0.138000 -0.287000 3.86e-02 1.70e-05
Regulation of mitotic cell cycle 75 2.15e-05 3.35e-04 0.31900 0.138000 -0.287000 3.86e-02 1.70e-05
Nucleotide-like (purinergic) receptors 13 1.28e-01 2.96e-01 0.31900 -0.063900 -0.312000 6.90e-01 5.13e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 1.12e-01 2.74e-01 0.31800 0.304000 -0.094500 4.15e-02 5.26e-01
NR1H2 and NR1H3-mediated signaling 38 2.99e-03 1.92e-02 0.31800 -0.318000 -0.005790 6.90e-04 9.51e-01
Cell-extracellular matrix interactions 15 1.21e-01 2.88e-01 0.31800 0.199000 -0.248000 1.82e-01 9.61e-02
Glucagon signaling in metabolic regulation 26 2.42e-02 9.63e-02 0.31800 0.133000 -0.289000 2.40e-01 1.08e-02
RHO GTPases activate KTN1 11 2.00e-01 3.87e-01 0.31800 0.081200 -0.307000 6.41e-01 7.77e-02
GP1b-IX-V activation signalling 10 2.33e-01 4.19e-01 0.31800 0.306000 -0.086700 9.43e-02 6.35e-01
Mismatch Repair 15 8.56e-02 2.26e-01 0.31700 -0.208000 -0.239000 1.62e-01 1.09e-01
EPHA-mediated growth cone collapse 21 5.29e-02 1.66e-01 0.31700 0.188000 -0.255000 1.36e-01 4.30e-02
Incretin synthesis, secretion, and inactivation 14 1.38e-01 3.10e-01 0.31600 0.139000 -0.284000 3.68e-01 6.57e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 1.38e-01 3.10e-01 0.31600 0.139000 -0.284000 3.68e-01 6.57e-02
IRAK4 deficiency (TLR2/4) 15 9.78e-02 2.50e-01 0.31600 -0.059700 -0.310000 6.89e-01 3.75e-02
Tight junction interactions 17 8.49e-02 2.25e-01 0.31600 -0.070200 0.308000 6.17e-01 2.80e-02
IFNG signaling activates MAPKs 8 3.23e-01 5.16e-01 0.31500 0.289000 -0.127000 1.57e-01 5.34e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.79e-01 3.63e-01 0.31500 0.090100 -0.302000 5.89e-01 7.01e-02
Removal of the Flap Intermediate from the C-strand 17 6.43e-02 1.86e-01 0.31500 -0.246000 -0.196000 7.85e-02 1.61e-01
NFE2L2 regulating ER-stress associated genes 5 4.48e-01 6.25e-01 0.31500 0.170000 0.265000 5.11e-01 3.05e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.25e-01 2.90e-01 0.31500 0.160000 -0.271000 2.83e-01 6.94e-02
CTNNB1 S37 mutants aren’t phosphorylated 15 1.25e-01 2.90e-01 0.31500 0.160000 -0.271000 2.83e-01 6.94e-02
CTNNB1 S45 mutants aren’t phosphorylated 15 1.25e-01 2.90e-01 0.31500 0.160000 -0.271000 2.83e-01 6.94e-02
CTNNB1 T41 mutants aren’t phosphorylated 15 1.25e-01 2.90e-01 0.31500 0.160000 -0.271000 2.83e-01 6.94e-02
Signaling by CTNNB1 phospho-site mutants 15 1.25e-01 2.90e-01 0.31500 0.160000 -0.271000 2.83e-01 6.94e-02
Signaling by GSK3beta mutants 15 1.25e-01 2.90e-01 0.31500 0.160000 -0.271000 2.83e-01 6.94e-02
Activated NTRK2 signals through RAS 6 4.18e-01 6.00e-01 0.31400 0.049500 -0.310000 8.34e-01 1.88e-01
Activated NTRK3 signals through RAS 6 4.18e-01 6.00e-01 0.31400 0.049500 -0.310000 8.34e-01 1.88e-01
ER-Phagosome pathway 74 3.72e-05 5.34e-04 0.31300 0.150000 -0.275000 2.61e-02 4.22e-05
Interactions of Vpr with host cellular proteins 37 6.51e-03 3.44e-02 0.31300 -0.212000 0.230000 2.53e-02 1.54e-02
Downstream signaling events of B Cell Receptor (BCR) 68 8.02e-05 9.57e-04 0.31300 0.130000 -0.285000 6.41e-02 4.82e-05
TGFBR3 regulates TGF-beta signaling 8 2.94e-01 4.89e-01 0.31300 -0.305000 -0.069700 1.35e-01 7.33e-01
ADORA2B mediated anti-inflammatory cytokines production 35 8.07e-03 4.02e-02 0.31300 0.142000 -0.278000 1.46e-01 4.37e-03
ER to Golgi Anterograde Transport 145 1.95e-09 6.03e-08 0.31200 0.117000 -0.290000 1.46e-02 1.74e-09
Reduction of cytosolic Ca++ levels 9 2.80e-01 4.74e-01 0.31200 0.081200 -0.302000 6.73e-01 1.17e-01
Tie2 Signaling 16 9.92e-02 2.52e-01 0.31200 0.032900 -0.310000 8.20e-01 3.16e-02
Protein ubiquitination 71 6.10e-05 7.68e-04 0.31200 0.150000 -0.274000 2.91e-02 6.62e-05
G alpha (z) signalling events 36 7.21e-03 3.69e-02 0.31100 0.281000 -0.134000 3.54e-03 1.63e-01
Evasion by RSV of host interferon responses 20 4.64e-02 1.51e-01 0.31100 -0.106000 -0.293000 4.13e-01 2.35e-02
Inwardly rectifying K+ channels 22 5.21e-02 1.65e-01 0.31100 0.220000 -0.220000 7.45e-02 7.36e-02
Lagging Strand Synthesis 20 5.99e-02 1.80e-01 0.31100 -0.304000 0.063900 1.86e-02 6.21e-01
TGFBR3 PTM regulation 10 2.49e-01 4.38e-01 0.31000 0.298000 -0.087400 1.03e-01 6.32e-01
Nuclear events mediated by NFE2L2 81 1.95e-05 3.23e-04 0.31000 0.177000 -0.254000 5.75e-03 7.54e-05
Sulfide oxidation to sulfate 5 5.11e-01 6.80e-01 0.31000 -0.182000 0.251000 4.80e-01 3.31e-01
Formation of apoptosome 11 2.12e-01 4.00e-01 0.31000 0.055000 -0.305000 7.52e-01 7.98e-02
Regulation of the apoptosome activity 11 2.12e-01 4.00e-01 0.31000 0.055000 -0.305000 7.52e-01 7.98e-02
Biotin transport and metabolism 11 2.26e-01 4.15e-01 0.31000 -0.272000 0.149000 1.19e-01 3.92e-01
Nectin/Necl trans heterodimerization 5 4.70e-01 6.46e-01 0.31000 -0.298000 -0.085500 2.49e-01 7.41e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 3.98e-01 5.87e-01 0.31000 -0.282000 -0.128000 2.32e-01 5.86e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 3.65e-01 5.57e-01 0.30900 -0.309000 0.005840 1.57e-01 9.79e-01
Activation of RAS in B cells 5 4.77e-01 6.51e-01 0.30900 -0.056300 -0.304000 8.27e-01 2.40e-01
Keratan sulfate biosynthesis 19 6.14e-02 1.82e-01 0.30900 -0.042200 -0.306000 7.50e-01 2.10e-02
Polymerase switching on the C-strand of the telomere 26 2.64e-02 1.02e-01 0.30900 -0.304000 0.052400 7.27e-03 6.44e-01
Adenylate cyclase activating pathway 8 3.43e-01 5.38e-01 0.30900 -0.153000 0.268000 4.54e-01 1.89e-01
Vpr-mediated nuclear import of PICs 34 1.12e-02 5.18e-02 0.30800 -0.237000 0.198000 1.69e-02 4.60e-02
HS-GAG degradation 18 7.70e-02 2.11e-01 0.30800 -0.009190 0.308000 9.46e-01 2.37e-02
Synthesis of PIPs at the ER membrane 5 4.65e-01 6.42e-01 0.30800 -0.266000 -0.155000 3.03e-01 5.48e-01
MyD88 deficiency (TLR2/4) 14 1.25e-01 2.91e-01 0.30800 -0.075900 -0.298000 6.23e-01 5.33e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 3.68e-11 1.54e-09 0.30800 0.150000 -0.268000 4.71e-04 4.25e-10
Signaling by cytosolic FGFR1 fusion mutants 18 7.44e-02 2.07e-01 0.30700 -0.025600 -0.306000 8.51e-01 2.45e-02
Olfactory Signaling Pathway 54 6.43e-04 5.24e-03 0.30700 0.295000 -0.086400 1.77e-04 2.72e-01
PI-3K cascade:FGFR1 13 1.64e-01 3.44e-01 0.30700 0.304000 -0.043100 5.76e-02 7.88e-01
E2F mediated regulation of DNA replication 22 4.73e-02 1.53e-01 0.30700 0.045000 -0.303000 7.15e-01 1.37e-02
Processive synthesis on the lagging strand 15 1.22e-01 2.89e-01 0.30700 -0.306000 0.020200 4.01e-02 8.93e-01
Cyclin E associated events during G1/S transition 73 5.30e-05 6.79e-04 0.30700 0.095200 -0.292000 1.60e-01 1.65e-05
Calcineurin activates NFAT 9 3.00e-01 4.94e-01 0.30700 0.115000 -0.284000 5.51e-01 1.40e-01
Fibronectin matrix formation 6 4.42e-01 6.19e-01 0.30600 0.296000 -0.078100 2.09e-01 7.40e-01
Regulation of signaling by CBL 22 4.43e-02 1.46e-01 0.30600 -0.001220 -0.306000 9.92e-01 1.28e-02
Acyl chain remodelling of PI 10 2.71e-01 4.67e-01 0.30600 0.232000 -0.200000 2.03e-01 2.74e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 2.58e-02 1.01e-01 0.30600 0.181000 -0.247000 9.78e-02 2.36e-02
CREB3 factors activate genes 6 4.09e-01 5.94e-01 0.30600 0.282000 0.118000 2.31e-01 6.16e-01
Platelet activation, signaling and aggregation 219 5.61e-13 2.77e-11 0.30600 0.237000 -0.193000 1.53e-09 8.29e-07
Signaling by KIT in disease 20 5.26e-02 1.66e-01 0.30500 -0.100000 -0.288000 4.38e-01 2.57e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 5.26e-02 1.66e-01 0.30500 -0.100000 -0.288000 4.38e-01 2.57e-02
Phospholipase C-mediated cascade: FGFR1 8 2.99e-01 4.94e-01 0.30500 0.175000 0.250000 3.92e-01 2.21e-01
Transport of RCbl within the body 8 3.37e-01 5.30e-01 0.30400 0.300000 -0.045300 1.41e-01 8.24e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.01e-01 3.88e-01 0.30400 -0.098300 -0.287000 5.72e-01 9.89e-02
APC/C:Cdc20 mediated degradation of Securin 55 8.07e-04 6.33e-03 0.30400 0.145000 -0.267000 6.24e-02 6.26e-04
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 1.71e-02 7.27e-02 0.30300 0.221000 -0.207000 3.03e-02 4.29e-02
IkBA variant leads to EDA-ID 7 3.83e-01 5.72e-01 0.30300 -0.017500 0.302000 9.36e-01 1.66e-01
Synthesis of PIPs at the late endosome membrane 11 2.43e-01 4.30e-01 0.30200 0.150000 -0.263000 3.89e-01 1.31e-01
Mitotic G1 phase and G1/S transition 138 1.08e-08 3.15e-07 0.30200 0.062000 -0.296000 2.08e-01 1.90e-09
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.41e-01 4.27e-01 0.30200 0.129000 -0.273000 4.59e-01 1.16e-01
Erythropoietin activates RAS 13 1.76e-01 3.61e-01 0.30200 0.049300 -0.298000 7.58e-01 6.31e-02
Separation of Sister Chromatids 167 5.45e-10 1.81e-08 0.30200 0.133000 -0.271000 2.99e-03 1.58e-09
Phase 2 - plateau phase 11 1.96e-01 3.84e-01 0.30100 -0.205000 -0.221000 2.39e-01 2.04e-01
Josephin domain DUBs 10 2.71e-01 4.67e-01 0.30100 0.286000 -0.094800 1.17e-01 6.04e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 4.13e-01 5.98e-01 0.30100 -0.176000 -0.245000 4.56e-01 3.00e-01
IRAK1 recruits IKK complex 14 1.49e-01 3.27e-01 0.30100 0.301000 -0.008800 5.15e-02 9.55e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 1.49e-01 3.27e-01 0.30100 0.301000 -0.008800 5.15e-02 9.55e-01
Meiotic recombination 36 1.10e-02 5.17e-02 0.30000 0.215000 -0.210000 2.54e-02 2.95e-02
Axonal growth inhibition (RHOA activation) 7 4.18e-01 6.00e-01 0.29900 0.231000 -0.190000 2.89e-01 3.84e-01
p75NTR regulates axonogenesis 7 4.18e-01 6.00e-01 0.29900 0.231000 -0.190000 2.89e-01 3.84e-01
Formation of the beta-catenin:TCF transactivating complex 44 3.36e-03 2.12e-02 0.29900 0.076500 -0.289000 3.80e-01 9.05e-04
Unwinding of DNA 12 1.86e-01 3.70e-01 0.29900 -0.077000 -0.289000 6.44e-01 8.32e-02
Synthesis of PIPs at the early endosome membrane 16 1.03e-01 2.59e-01 0.29900 -0.111000 -0.277000 4.41e-01 5.48e-02
Sema4D in semaphorin signaling 22 5.50e-02 1.69e-01 0.29900 0.296000 -0.037600 1.61e-02 7.60e-01
EML4 and NUDC in mitotic spindle formation 106 1.74e-06 3.76e-05 0.29800 0.133000 -0.267000 1.77e-02 2.08e-06
Assembly of the pre-replicative complex 87 1.99e-05 3.25e-04 0.29800 0.148000 -0.258000 1.67e-02 3.07e-05
Inactivation, recovery and regulation of the phototransduction cascade 25 4.04e-02 1.38e-01 0.29800 0.288000 -0.076900 1.28e-02 5.06e-01
Golgi Associated Vesicle Biogenesis 55 1.22e-03 8.95e-03 0.29700 0.225000 -0.193000 3.91e-03 1.31e-02
Signaling by FLT3 ITD and TKD mutants 15 1.54e-01 3.32e-01 0.29700 0.120000 -0.271000 4.19e-01 6.91e-02
EPH-Ephrin signaling 79 6.68e-05 8.28e-04 0.29600 0.195000 -0.223000 2.69e-03 6.13e-04
RUNX3 regulates WNT signaling 8 3.36e-01 5.29e-01 0.29600 -0.060000 -0.290000 7.69e-01 1.56e-01
G2/M Checkpoints 126 1.86e-07 4.89e-06 0.29600 0.129000 -0.266000 1.23e-02 2.51e-07
Negative regulation of FGFR1 signaling 25 4.09e-02 1.38e-01 0.29500 0.291000 -0.050000 1.18e-02 6.65e-01
Platelet calcium homeostasis 22 6.13e-02 1.82e-01 0.29500 0.059500 -0.289000 6.29e-01 1.90e-02
Telomere Extension By Telomerase 23 6.28e-02 1.84e-01 0.29400 0.205000 -0.212000 8.93e-02 7.88e-02
Activation of BAD and translocation to mitochondria 15 1.40e-01 3.13e-01 0.29400 0.294000 0.005410 4.84e-02 9.71e-01
NIK–>noncanonical NF-kB signaling 46 3.16e-03 2.01e-02 0.29400 0.076800 -0.284000 3.68e-01 8.58e-04
Antigen processing-Cross presentation 88 2.04e-05 3.27e-04 0.29400 0.112000 -0.272000 6.93e-02 1.04e-05
RAB geranylgeranylation 61 5.88e-04 4.91e-03 0.29400 0.128000 -0.265000 8.42e-02 3.49e-04
Intra-Golgi and retrograde Golgi-to-ER traffic 191 8.73e-11 3.49e-09 0.29400 0.124000 -0.266000 3.21e-03 2.15e-10
Cellular response to mitochondrial stress 9 3.16e-01 5.10e-01 0.29400 0.029600 -0.292000 8.78e-01 1.29e-01
Regulation of HMOX1 expression and activity 5 5.38e-01 6.99e-01 0.29300 -0.089800 0.279000 7.28e-01 2.79e-01
Formation of ATP by chemiosmotic coupling 20 7.96e-02 2.16e-01 0.29200 0.290000 -0.034700 2.46e-02 7.88e-01
Interleukin-2 signaling 11 2.18e-01 4.07e-01 0.29200 -0.166000 -0.241000 3.41e-01 1.67e-01
Reactions specific to the complex N-glycan synthesis pathway 7 4.17e-01 6.00e-01 0.29200 0.287000 -0.052300 1.88e-01 8.11e-01
Interleukin-2 family signaling 38 5.43e-03 3.02e-02 0.29200 -0.148000 -0.252000 1.15e-01 7.29e-03
Potential therapeutics for SARS 147 2.27e-08 6.42e-07 0.29100 0.122000 -0.265000 1.09e-02 2.94e-08
Endosomal Sorting Complex Required For Transport (ESCRT) 29 2.94e-02 1.12e-01 0.29100 0.092900 -0.276000 3.87e-01 1.01e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 24 5.91e-02 1.78e-01 0.29100 0.232000 -0.176000 4.91e-02 1.36e-01
Signal transduction by L1 20 9.43e-02 2.44e-01 0.29100 0.240000 -0.164000 6.31e-02 2.04e-01
Trafficking and processing of endosomal TLR 13 1.68e-01 3.49e-01 0.29000 -0.225000 -0.183000 1.59e-01 2.53e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 3.58e-01 5.51e-01 0.29000 -0.019800 -0.290000 9.23e-01 1.56e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.61e-01 4.53e-01 0.29000 0.073000 -0.281000 6.75e-01 1.07e-01
Purine salvage 12 1.95e-01 3.82e-01 0.29000 -0.180000 -0.227000 2.79e-01 1.74e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.15e-01 2.80e-01 0.29000 -0.097400 0.273000 4.74e-01 4.52e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 2.58e-01 4.49e-01 0.29000 0.248000 0.149000 1.74e-01 4.13e-01
Role of ABL in ROBO-SLIT signaling 6 4.88e-01 6.60e-01 0.28900 0.106000 -0.269000 6.54e-01 2.53e-01
SUMOylation of transcription factors 16 1.46e-01 3.22e-01 0.28900 -0.093000 0.274000 5.20e-01 5.77e-02
Bicarbonate transporters 9 2.96e-01 4.90e-01 0.28900 -0.243000 -0.156000 2.06e-01 4.17e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 4.99e-01 6.67e-01 0.28900 0.203000 -0.205000 3.88e-01 3.84e-01
Syndecan interactions 23 5.04e-02 1.61e-01 0.28900 0.282000 0.060900 1.91e-02 6.13e-01
Expression and translocation of olfactory receptors 49 2.87e-03 1.86e-02 0.28900 0.274000 -0.089700 8.96e-04 2.77e-01
G1/S Transition 120 5.18e-07 1.24e-05 0.28800 0.063000 -0.281000 2.33e-01 1.01e-07
DAP12 signaling 28 3.59e-02 1.27e-01 0.28800 0.092700 -0.273000 3.96e-01 1.25e-02
Signal regulatory protein family interactions 13 2.03e-01 3.91e-01 0.28700 0.023500 -0.286000 8.83e-01 7.41e-02
Signal amplification 28 4.07e-02 1.38e-01 0.28700 0.171000 -0.230000 1.17e-01 3.52e-02
Neurexins and neuroligins 35 1.73e-02 7.32e-02 0.28700 -0.257000 0.127000 8.46e-03 1.95e-01
Interleukin-23 signaling 7 3.93e-01 5.81e-01 0.28700 -0.178000 -0.225000 4.16e-01 3.03e-01
Vesicle-mediated transport 662 5.22e-33 1.00e-29 0.28700 0.140000 -0.250000 7.49e-10 4.98e-28
Neutrophil degranulation 456 4.41e-23 1.67e-20 0.28600 0.148000 -0.246000 6.73e-08 2.46e-19
Processing and activation of SUMO 10 2.98e-01 4.93e-01 0.28600 0.040400 -0.283000 8.25e-01 1.21e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 90 3.06e-05 4.55e-04 0.28600 0.116000 -0.261000 5.69e-02 1.85e-05
Amplification of signal from the kinetochores 90 3.06e-05 4.55e-04 0.28600 0.116000 -0.261000 5.69e-02 1.85e-05
Other interleukin signaling 18 9.49e-02 2.44e-01 0.28600 -0.257000 -0.124000 5.88e-02 3.62e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 4.35e-01 6.14e-01 0.28500 0.060000 -0.279000 7.83e-01 2.01e-01
Heme biosynthesis 13 2.04e-01 3.91e-01 0.28500 -0.285000 0.008570 7.49e-02 9.57e-01
Receptor Mediated Mitophagy 11 2.88e-01 4.83e-01 0.28500 0.226000 -0.173000 1.94e-01 3.19e-01
Depolymerization of the Nuclear Lamina 15 1.85e-01 3.69e-01 0.28500 0.200000 -0.203000 1.81e-01 1.73e-01
Kinesins 51 2.94e-03 1.90e-02 0.28400 0.123000 -0.257000 1.30e-01 1.52e-03
Regulation of RUNX3 expression and activity 45 6.19e-03 3.31e-02 0.28400 0.154000 -0.239000 7.45e-02 5.48e-03
EGFR interacts with phospholipase C-gamma 6 5.09e-01 6.78e-01 0.28400 -0.175000 0.224000 4.59e-01 3.42e-01
COPII-mediated vesicle transport 67 3.73e-04 3.41e-03 0.28400 0.054000 -0.279000 4.44e-01 7.89e-05
RUNX3 regulates p14-ARF 10 3.18e-01 5.12e-01 0.28400 0.260000 -0.113000 1.54e-01 5.36e-01
Constitutive Signaling by Overexpressed ERBB2 11 2.76e-01 4.70e-01 0.28300 0.059900 -0.277000 7.31e-01 1.12e-01
Elevation of cytosolic Ca2+ levels 13 2.16e-01 4.04e-01 0.28300 0.044300 -0.280000 7.82e-01 8.09e-02
Transcriptional regulation of pluripotent stem cells 18 1.34e-01 3.04e-01 0.28300 0.168000 -0.228000 2.17e-01 9.46e-02
Acyl chain remodeling of CL 5 5.40e-01 6.99e-01 0.28300 -0.036700 -0.280000 8.87e-01 2.78e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 3.97e-01 5.86e-01 0.28300 0.272000 -0.077500 1.83e-01 7.04e-01
Downstream signal transduction 27 3.83e-02 1.32e-01 0.28300 -0.006150 -0.282000 9.56e-01 1.11e-02
Maternal to zygotic transition (MZT) 71 3.61e-04 3.34e-03 0.28200 0.246000 -0.138000 3.35e-04 4.44e-02
Vitamin B1 (thiamin) metabolism 5 5.25e-01 6.89e-01 0.28200 0.153000 0.237000 5.53e-01 3.59e-01
Regulation of FOXO transcriptional activity by acetylation 10 2.92e-01 4.87e-01 0.28200 0.278000 0.047400 1.28e-01 7.95e-01
Aggrephagy 34 2.22e-02 9.01e-02 0.28200 0.252000 -0.126000 1.10e-02 2.03e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 6.02e-02 1.80e-01 0.28200 0.116000 -0.257000 3.17e-01 2.63e-02
Interleukin-18 signaling 6 5.05e-01 6.74e-01 0.28100 0.267000 -0.089900 2.58e-01 7.03e-01
RHOJ GTPase cycle 49 4.06e-03 2.44e-02 0.28100 0.260000 -0.108000 1.67e-03 1.90e-01
Dermatan sulfate biosynthesis 6 4.71e-01 6.46e-01 0.28100 0.263000 0.098800 2.64e-01 6.75e-01
Aflatoxin activation and detoxification 14 1.81e-01 3.65e-01 0.28100 -0.277000 -0.045100 7.22e-02 7.70e-01
Hemostasis 552 2.16e-26 1.04e-23 0.28100 0.184000 -0.212000 1.34e-13 1.60e-17
G1/S DNA Damage Checkpoints 54 2.44e-03 1.62e-02 0.28000 0.114000 -0.256000 1.48e-01 1.12e-03
Complex III assembly 23 5.87e-02 1.78e-01 0.28000 0.071100 0.271000 5.55e-01 2.43e-02
Sulfur amino acid metabolism 22 8.57e-02 2.26e-01 0.28000 -0.105000 0.260000 3.96e-01 3.50e-02
Sodium/Calcium exchangers 9 3.74e-01 5.65e-01 0.28000 0.232000 -0.156000 2.29e-01 4.17e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 1.77e-01 3.62e-01 0.27900 -0.091800 -0.264000 5.52e-01 8.73e-02
Regulation of RUNX2 expression and activity 54 2.53e-03 1.67e-02 0.27900 0.103000 -0.259000 1.89e-01 9.89e-04
Mitotic Anaphase 210 1.35e-10 4.90e-09 0.27800 0.130000 -0.246000 1.15e-03 7.95e-10
Activation of the AP-1 family of transcription factors 10 3.42e-01 5.38e-01 0.27800 0.216000 -0.175000 2.38e-01 3.38e-01
RAS processing 23 8.51e-02 2.25e-01 0.27700 0.229000 -0.156000 5.70e-02 1.97e-01
Mitotic Metaphase and Anaphase 211 1.51e-10 5.38e-09 0.27700 0.129000 -0.245000 1.29e-03 8.15e-10
Base-Excision Repair, AP Site Formation 28 4.84e-02 1.56e-01 0.27700 0.249000 -0.120000 2.24e-02 2.73e-01
ADP signalling through P2Y purinoceptor 1 21 1.00e-01 2.54e-01 0.27600 0.089500 -0.262000 4.78e-01 3.80e-02
CDK-mediated phosphorylation and removal of Cdc6 60 1.64e-03 1.16e-02 0.27600 0.131000 -0.243000 7.89e-02 1.15e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 1.44e-03 1.04e-02 0.27600 0.122000 -0.248000 1.01e-01 8.26e-04
Activation of SMO 13 2.04e-01 3.91e-01 0.27600 -0.241000 -0.135000 1.33e-01 4.01e-01
Specification of primordial germ cells 6 4.94e-01 6.63e-01 0.27600 0.046000 0.272000 8.45e-01 2.49e-01
Dectin-1 mediated noncanonical NF-kB signaling 47 6.16e-03 3.30e-02 0.27300 0.067600 -0.265000 4.23e-01 1.68e-03
B-WICH complex positively regulates rRNA expression 45 5.92e-03 3.21e-02 0.27300 0.272000 0.021400 1.56e-03 8.04e-01
PI3K events in ERBB4 signaling 6 5.34e-01 6.94e-01 0.27300 -0.237000 0.135000 3.14e-01 5.68e-01
Detoxification of Reactive Oxygen Species 30 3.55e-02 1.26e-01 0.27200 0.009690 -0.272000 9.27e-01 9.85e-03
Removal of the Flap Intermediate 14 2.01e-01 3.88e-01 0.27200 -0.269000 -0.043700 8.16e-02 7.77e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 6.32e-02 1.84e-01 0.27200 0.020900 -0.272000 8.56e-01 1.88e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 6.32e-02 1.84e-01 0.27200 0.020900 -0.272000 8.56e-01 1.88e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 6.32e-02 1.84e-01 0.27200 0.020900 -0.272000 8.56e-01 1.88e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 6.32e-02 1.84e-01 0.27200 0.020900 -0.272000 8.56e-01 1.88e-02
Methionine salvage pathway 6 5.19e-01 6.86e-01 0.27200 -0.269000 0.042000 2.54e-01 8.59e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.85e-01 3.69e-01 0.27200 -0.179000 -0.205000 2.46e-01 1.84e-01
Folding of actin by CCT/TriC 10 3.54e-01 5.49e-01 0.27200 0.139000 -0.234000 4.46e-01 2.01e-01
Calnexin/calreticulin cycle 26 7.01e-02 1.97e-01 0.27100 0.191000 -0.193000 9.21e-02 8.83e-02
O-linked glycosylation of mucins 46 6.90e-03 3.57e-02 0.27100 0.040900 -0.268000 6.32e-01 1.65e-03
ABC-family proteins mediated transport 81 2.53e-04 2.60e-03 0.27100 0.149000 -0.226000 2.00e-02 4.40e-04
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 1.34e-01 3.04e-01 0.27100 -0.129000 -0.238000 3.57e-01 8.92e-02
Cyclin A:Cdk2-associated events at S phase entry 75 3.63e-04 3.34e-03 0.27100 0.075500 -0.260000 2.58e-01 9.84e-05
Synthesis of Ketone Bodies 6 5.26e-01 6.90e-01 0.27100 0.055900 -0.265000 8.13e-01 2.61e-01
Recycling pathway of L1 40 1.68e-02 7.20e-02 0.27000 0.229000 -0.144000 1.22e-02 1.16e-01
The activation of arylsulfatases 10 3.08e-01 5.03e-01 0.27000 0.232000 0.139000 2.05e-01 4.47e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.08e-01 2.68e-01 0.27000 0.162000 -0.215000 1.87e-01 8.04e-02
p75NTR signals via NF-kB 15 1.77e-01 3.62e-01 0.26900 0.101000 0.250000 5.00e-01 9.39e-02
Linoleic acid (LA) metabolism 7 4.39e-01 6.17e-01 0.26900 -0.175000 -0.204000 4.24e-01 3.49e-01
G-protein activation 19 1.48e-01 3.27e-01 0.26900 0.168000 -0.210000 2.06e-01 1.13e-01
Negative regulation of FGFR4 signaling 22 1.09e-01 2.69e-01 0.26800 0.226000 -0.144000 6.61e-02 2.41e-01
FLT3 signaling in disease 27 4.72e-02 1.53e-01 0.26800 -0.072100 -0.259000 5.17e-01 2.01e-02
H139Hfs13* PPM1K causes a mild variant of MSUD 5 6.06e-01 7.53e-01 0.26800 0.222000 -0.150000 3.90e-01 5.62e-01
Maple Syrup Urine Disease 5 6.06e-01 7.53e-01 0.26800 0.222000 -0.150000 3.90e-01 5.62e-01
AMPK inhibits chREBP transcriptional activation activity 6 4.98e-01 6.67e-01 0.26800 0.153000 0.220000 5.18e-01 3.51e-01
Gap junction trafficking 27 6.85e-02 1.94e-01 0.26800 0.181000 -0.197000 1.03e-01 7.65e-02
Defects in cobalamin (B12) metabolism 13 2.21e-01 4.09e-01 0.26700 -0.176000 -0.201000 2.71e-01 2.10e-01
SARS-CoV-1 modulates host translation machinery 36 2.01e-02 8.33e-02 0.26700 0.015700 0.267000 8.70e-01 5.64e-03
Signaling by SCF-KIT 40 1.50e-02 6.50e-02 0.26700 0.036600 -0.264000 6.89e-01 3.81e-03
p38MAPK events 13 2.56e-01 4.46e-01 0.26600 0.034600 -0.264000 8.29e-01 9.91e-02
Sema3A PAK dependent Axon repulsion 15 2.12e-01 4.00e-01 0.26600 0.055400 -0.261000 7.10e-01 8.07e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 1.53e-01 3.32e-01 0.26600 -0.060000 -0.259000 6.68e-01 6.46e-02
Maturation of nucleoprotein 9683610 11 3.41e-01 5.36e-01 0.26500 0.177000 -0.198000 3.11e-01 2.55e-01
Glycine degradation 7 4.98e-01 6.67e-01 0.26500 0.109000 -0.242000 6.18e-01 2.68e-01
Glucagon-type ligand receptors 19 1.49e-01 3.27e-01 0.26500 0.095200 -0.247000 4.73e-01 6.19e-02
Interleukin-37 signaling 19 1.52e-01 3.32e-01 0.26500 0.118000 -0.237000 3.75e-01 7.33e-02
Serotonin Neurotransmitter Release Cycle 15 2.13e-01 4.00e-01 0.26500 -0.262000 0.039400 7.93e-02 7.91e-01
Synthesis of PG 8 4.48e-01 6.25e-01 0.26500 -0.250000 0.087400 2.21e-01 6.69e-01
eNOS activation 10 3.60e-01 5.55e-01 0.26500 0.056300 -0.258000 7.58e-01 1.57e-01
HS-GAG biosynthesis 19 1.55e-01 3.34e-01 0.26400 0.128000 -0.231000 3.36e-01 8.08e-02
Budding and maturation of HIV virion 26 7.83e-02 2.14e-01 0.26400 0.131000 -0.229000 2.46e-01 4.31e-02
ROS and RNS production in phagocytes 30 5.34e-02 1.67e-01 0.26400 0.139000 -0.224000 1.87e-01 3.33e-02
Displacement of DNA glycosylase by APEX1 9 4.14e-01 5.98e-01 0.26400 -0.126000 0.232000 5.13e-01 2.28e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 7.92e-03 3.99e-02 0.26400 0.162000 -0.208000 4.76e-02 1.08e-02
Interleukin-6 family signaling 18 1.31e-01 2.99e-01 0.26400 -0.209000 -0.161000 1.24e-01 2.38e-01
SHC-related events triggered by IGF1R 7 4.86e-01 6.58e-01 0.26400 0.028500 -0.262000 8.96e-01 2.30e-01
Erythrocytes take up oxygen and release carbon dioxide 7 5.09e-01 6.78e-01 0.26400 0.179000 -0.193000 4.11e-01 3.76e-01
Hedgehog ‘on’ state 64 1.60e-03 1.14e-02 0.26300 0.064200 -0.256000 3.74e-01 4.06e-04
Peptide chain elongation 88 1.06e-04 1.20e-03 0.26300 -0.003410 0.263000 9.56e-01 1.97e-05
Signaling by FGFR3 32 4.63e-02 1.51e-01 0.26300 0.178000 -0.193000 8.06e-02 5.84e-02
MET activates RAS signaling 10 3.82e-01 5.71e-01 0.26300 0.156000 -0.212000 3.94e-01 2.46e-01
SOS-mediated signalling 7 4.85e-01 6.58e-01 0.26300 0.262000 -0.011500 2.29e-01 9.58e-01
Fatty acyl-CoA biosynthesis 35 3.30e-02 1.20e-01 0.26300 0.113000 -0.237000 2.45e-01 1.53e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 4.66e-02 1.51e-01 0.26300 -0.204000 0.166000 4.61e-02 1.05e-01
RNA Polymerase I Promoter Escape 45 9.75e-03 4.64e-02 0.26300 0.262000 -0.015300 2.35e-03 8.59e-01
Non-integrin membrane-ECM interactions 46 6.79e-03 3.53e-02 0.26200 0.247000 0.086500 3.71e-03 3.10e-01
EGFR downregulation 26 8.08e-02 2.18e-01 0.26200 0.234000 -0.117000 3.89e-02 3.00e-01
Signaling by Erythropoietin 24 7.73e-02 2.12e-01 0.26200 -0.055500 -0.256000 6.38e-01 3.01e-02
FOXO-mediated transcription of cell death genes 16 1.81e-01 3.65e-01 0.26200 0.060600 0.255000 6.75e-01 7.79e-02
Beta-oxidation of pristanoyl-CoA 9 3.80e-01 5.69e-01 0.26100 -0.071900 -0.251000 7.09e-01 1.92e-01
Glycosphingolipid biosynthesis 15 2.24e-01 4.12e-01 0.26100 0.052700 -0.256000 7.24e-01 8.62e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 3.36e-01 5.30e-01 0.26100 -0.103000 -0.240000 5.72e-01 1.89e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 3.04e-04 2.94e-03 0.26100 0.134000 -0.224000 3.23e-02 3.60e-04
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 3.04e-04 2.94e-03 0.26100 0.134000 -0.224000 3.23e-02 3.60e-04
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 3.04e-04 2.94e-03 0.26100 0.134000 -0.224000 3.23e-02 3.60e-04
Cargo trafficking to the periciliary membrane 47 5.56e-03 3.08e-02 0.26100 -0.172000 -0.196000 4.15e-02 2.01e-02
Impaired BRCA2 binding to PALB2 24 8.78e-02 2.30e-01 0.26100 0.016700 -0.260000 8.87e-01 2.74e-02
TRAF3-dependent IRF activation pathway 13 2.48e-01 4.36e-01 0.26100 -0.247000 -0.083200 1.23e-01 6.04e-01
Induction of Cell-Cell Fusion 8 4.42e-01 6.19e-01 0.26100 0.003520 -0.260000 9.86e-01 2.02e-01
Formation of paraxial mesoderm 52 6.90e-03 3.57e-02 0.26000 0.106000 -0.237000 1.87e-01 3.06e-03
Selective autophagy 77 6.74e-04 5.44e-03 0.26000 0.230000 -0.120000 4.71e-04 6.94e-02
Formation of a pool of free 40S subunits 100 3.38e-05 4.99e-04 0.26000 0.026300 0.258000 6.50e-01 8.04e-06
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 6.09e-01 7.55e-01 0.26000 -0.039400 0.257000 8.79e-01 3.21e-01
Nucleotide biosynthesis 12 3.20e-01 5.12e-01 0.25900 -0.233000 0.113000 1.61e-01 5.00e-01
rRNA modification in the nucleus and cytosol 59 1.62e-03 1.15e-02 0.25900 0.156000 0.207000 3.78e-02 6.03e-03
Miscellaneous substrates 7 5.19e-01 6.86e-01 0.25900 -0.152000 0.210000 4.85e-01 3.37e-01
Cyclin D associated events in G1 47 8.18e-03 4.03e-02 0.25900 -0.018000 -0.258000 8.31e-01 2.17e-03
G1 Phase 47 8.18e-03 4.03e-02 0.25900 -0.018000 -0.258000 8.31e-01 2.17e-03
Activation of the TFAP2 (AP-2) family of transcription factors 7 4.87e-01 6.59e-01 0.25900 0.028500 0.257000 8.96e-01 2.39e-01
Cell Cycle Checkpoints 245 1.17e-10 4.38e-09 0.25900 0.118000 -0.230000 1.47e-03 5.57e-10
M-decay: degradation of maternal mRNAs by maternally stored factors 41 2.23e-02 9.01e-02 0.25800 0.201000 -0.162000 2.56e-02 7.28e-02
p53-Dependent G1 DNA Damage Response 52 7.29e-03 3.70e-02 0.25800 0.098600 -0.238000 2.19e-01 2.93e-03
p53-Dependent G1/S DNA damage checkpoint 52 7.29e-03 3.70e-02 0.25800 0.098600 -0.238000 2.19e-01 2.93e-03
GPVI-mediated activation cascade 31 5.23e-02 1.65e-01 0.25800 0.088700 -0.242000 3.93e-01 1.96e-02
RHOV GTPase cycle 36 2.44e-02 9.66e-02 0.25800 -0.049100 -0.253000 6.10e-01 8.61e-03
p75NTR recruits signalling complexes 12 2.76e-01 4.70e-01 0.25800 0.134000 0.220000 4.21e-01 1.87e-01
Constitutive Signaling by EGFRvIII 14 2.50e-01 4.38e-01 0.25700 0.013900 -0.257000 9.28e-01 9.58e-02
Signaling by EGFRvIII in Cancer 14 2.50e-01 4.38e-01 0.25700 0.013900 -0.257000 9.28e-01 9.58e-02
Vitamin B2 (riboflavin) metabolism 6 5.64e-01 7.19e-01 0.25700 -0.246000 0.073900 2.96e-01 7.54e-01
PI3K/AKT activation 8 4.79e-01 6.53e-01 0.25700 0.208000 -0.150000 3.07e-01 4.63e-01
Neurofascin interactions 5 6.28e-01 7.70e-01 0.25700 0.228000 -0.118000 3.77e-01 6.47e-01
Na+/Cl- dependent neurotransmitter transporters 7 5.06e-01 6.74e-01 0.25700 0.255000 -0.030700 2.43e-01 8.88e-01
Aquaporin-mediated transport 38 3.09e-02 1.16e-01 0.25600 0.153000 -0.206000 1.03e-01 2.80e-02
RHO GTPases Activate Formins 127 7.29e-06 1.30e-04 0.25600 0.095700 -0.238000 6.26e-02 3.69e-06
Switching of origins to a post-replicative state 79 5.94e-04 4.92e-03 0.25600 0.079000 -0.244000 2.25e-01 1.81e-04
Amine ligand-binding receptors 10 3.72e-01 5.63e-01 0.25600 -0.256000 0.001100 1.61e-01 9.95e-01
Processive synthesis on the C-strand of the telomere 19 1.34e-01 3.04e-01 0.25600 -0.216000 -0.138000 1.04e-01 2.99e-01
Nuclear Receptor transcription pathway 38 3.13e-02 1.16e-01 0.25600 -0.208000 0.149000 2.67e-02 1.11e-01
The NLRP3 inflammasome 16 2.34e-01 4.20e-01 0.25600 -0.174000 0.187000 2.28e-01 1.94e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 7.25e-03 3.70e-02 0.25500 0.128000 -0.221000 1.05e-01 4.98e-03
Arachidonate production from DAG 5 5.90e-01 7.42e-01 0.25500 0.146000 0.209000 5.72e-01 4.18e-01
Synthesis of PC 23 1.06e-01 2.65e-01 0.25500 0.255000 -0.007780 3.44e-02 9.49e-01
Transcriptional Regulation by MECP2 47 7.63e-03 3.87e-02 0.25500 -0.109000 -0.230000 1.95e-01 6.37e-03
Eukaryotic Translation Elongation 93 1.21e-04 1.35e-03 0.25500 -0.007010 0.254000 9.07e-01 2.22e-05
DNA Replication Pre-Initiation 103 9.22e-05 1.08e-03 0.25500 0.140000 -0.213000 1.40e-02 1.94e-04
Regulation of mRNA stability by proteins that bind AU-rich elements 76 8.69e-04 6.64e-03 0.25400 0.075200 -0.243000 2.57e-01 2.54e-04
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 2.24e-01 4.12e-01 0.25400 -0.246000 0.064200 8.87e-02 6.56e-01
Membrane Trafficking 575 5.21e-23 1.67e-20 0.25400 0.103000 -0.232000 2.65e-05 1.71e-21
FGFR1 ligand binding and activation 10 3.57e-01 5.51e-01 0.25400 0.103000 0.232000 5.74e-01 2.04e-01
Ketone body metabolism 8 4.85e-01 6.58e-01 0.25400 0.123000 -0.222000 5.46e-01 2.77e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 5.32e-01 6.93e-01 0.25400 0.217000 -0.132000 3.20e-01 5.47e-01
Biosynthesis of maresins 5 5.94e-01 7.44e-01 0.25300 -0.204000 -0.151000 4.30e-01 5.60e-01
Defects in vitamin and cofactor metabolism 21 1.25e-01 2.91e-01 0.25300 -0.250000 -0.040300 4.74e-02 7.49e-01
Integrin signaling 22 1.34e-01 3.04e-01 0.25300 0.236000 -0.090500 5.50e-02 4.62e-01
Repression of WNT target genes 14 2.34e-01 4.20e-01 0.25200 -0.170000 -0.187000 2.72e-01 2.26e-01
Signaling by NOTCH4 68 2.43e-03 1.62e-02 0.25200 0.153000 -0.201000 2.89e-02 4.22e-03
Synthesis of GDP-mannose 6 5.40e-01 6.99e-01 0.25200 0.214000 0.133000 3.64e-01 5.72e-01
KEAP1-NFE2L2 pathway 106 9.24e-05 1.08e-03 0.25200 0.165000 -0.190000 3.34e-03 7.21e-04
Vitamin D (calciferol) metabolism 10 3.74e-01 5.65e-01 0.25200 -0.247000 -0.047500 1.76e-01 7.95e-01
IRE1alpha activates chaperones 46 1.43e-02 6.24e-02 0.25100 0.247000 -0.048800 3.79e-03 5.67e-01
Response of Mtb to phagocytosis 22 1.44e-01 3.19e-01 0.25100 0.199000 -0.154000 1.07e-01 2.10e-01
Chemokine receptors bind chemokines 38 2.61e-02 1.02e-01 0.25100 0.251000 0.010400 7.36e-03 9.12e-01
Interleukin-12 signaling 44 1.77e-02 7.48e-02 0.25100 0.056600 -0.245000 5.16e-01 4.97e-03
ERBB2 Activates PTK6 Signaling 8 4.73e-01 6.48e-01 0.25100 -0.024800 0.250000 9.03e-01 2.21e-01
TCF dependent signaling in response to WNT 150 1.33e-06 2.93e-05 0.25100 0.069200 -0.241000 1.44e-01 3.51e-07
Meiotic synapsis 43 2.29e-02 9.23e-02 0.25100 0.133000 -0.213000 1.32e-01 1.59e-02
Gap junction trafficking and regulation 29 8.03e-02 2.17e-01 0.25000 0.153000 -0.198000 1.53e-01 6.55e-02
Platelet homeostasis 69 2.14e-03 1.46e-02 0.25000 0.081200 -0.236000 2.44e-01 6.99e-04
Signaling by NODAL 15 2.36e-01 4.23e-01 0.24900 0.246000 0.041200 9.91e-02 7.82e-01
FRS-mediated FGFR3 signaling 12 3.55e-01 5.49e-01 0.24900 0.152000 -0.197000 3.62e-01 2.36e-01
Netrin-1 signaling 34 5.34e-02 1.67e-01 0.24900 0.193000 -0.158000 5.19e-02 1.11e-01
Signaling by high-kinase activity BRAF mutants 33 5.90e-02 1.78e-01 0.24900 0.169000 -0.182000 9.24e-02 7.02e-02
Growth hormone receptor signaling 20 1.55e-01 3.34e-01 0.24900 -0.001890 -0.249000 9.88e-01 5.43e-02
Scavenging by Class A Receptors 10 3.95e-01 5.85e-01 0.24800 0.248000 -0.005650 1.74e-01 9.75e-01
Selenocysteine synthesis 92 2.08e-04 2.22e-03 0.24800 -0.009890 0.248000 8.70e-01 3.88e-05
Abacavir ADME 5 6.35e-01 7.74e-01 0.24800 0.029000 -0.246000 9.11e-01 3.41e-01
Transport of nucleotide sugars 9 4.17e-01 6.00e-01 0.24800 0.082400 0.233000 6.69e-01 2.25e-01
Interleukin-12 family signaling 53 9.74e-03 4.64e-02 0.24700 0.078500 -0.234000 3.23e-01 3.19e-03
Rap1 signalling 14 3.07e-01 5.03e-01 0.24600 0.171000 -0.178000 2.69e-01 2.50e-01
DNA replication initiation 8 4.95e-01 6.64e-01 0.24600 -0.062600 0.238000 7.59e-01 2.43e-01
Asymmetric localization of PCP proteins 49 1.64e-02 7.05e-02 0.24500 0.146000 -0.197000 7.66e-02 1.69e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 2.29e-01 4.17e-01 0.24500 0.245000 0.020100 9.03e-02 8.89e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.23e-03 2.05e-02 0.24500 0.132000 0.207000 7.99e-02 5.97e-03
PRC2 methylates histones and DNA 27 1.05e-01 2.62e-01 0.24500 0.186000 -0.159000 9.38e-02 1.51e-01
The phototransduction cascade 26 1.02e-01 2.57e-01 0.24400 0.241000 -0.039100 3.32e-02 7.30e-01
RHOG GTPase cycle 70 3.05e-03 1.95e-02 0.24400 0.164000 -0.181000 1.78e-02 8.67e-03
STAT5 activation downstream of FLT3 ITD mutants 9 4.74e-01 6.48e-01 0.24400 0.191000 -0.153000 3.22e-01 4.28e-01
Negative regulation of FGFR2 signaling 24 1.37e-01 3.08e-01 0.24400 0.186000 -0.158000 1.15e-01 1.80e-01
Formation of the cornified envelope 32 6.15e-02 1.82e-01 0.24400 0.240000 -0.047000 1.90e-02 6.45e-01
Signaling by MET 66 4.34e-03 2.55e-02 0.24400 0.175000 -0.170000 1.39e-02 1.70e-02
Telomere C-strand (Lagging Strand) Synthesis 34 5.04e-02 1.61e-01 0.24400 -0.242000 0.029200 1.46e-02 7.69e-01
MET promotes cell motility 31 7.36e-02 2.05e-01 0.24400 0.222000 -0.101000 3.25e-02 3.31e-01
MAP2K and MAPK activation 36 5.16e-02 1.64e-01 0.24400 0.157000 -0.186000 1.03e-01 5.33e-02
Regulation of pyruvate metabolism 32 7.03e-02 1.98e-01 0.24300 0.124000 -0.209000 2.24e-01 4.06e-02
Export of Viral Ribonucleoproteins from Nucleus 33 6.70e-02 1.91e-01 0.24300 -0.170000 0.173000 9.03e-02 8.49e-02
Apoptosis 157 2.33e-06 4.77e-05 0.24300 0.112000 -0.215000 1.53e-02 3.20e-06
Small interfering RNA (siRNA) biogenesis 9 4.68e-01 6.43e-01 0.24200 0.075200 -0.230000 6.96e-01 2.32e-01
NPAS4 regulates expression of target genes 16 2.37e-01 4.23e-01 0.24200 0.239000 0.033100 9.73e-02 8.19e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 5.89e-02 1.78e-01 0.24200 0.175000 -0.167000 7.33e-02 8.81e-02
RAB GEFs exchange GTP for GDP on RABs 89 6.05e-04 4.98e-03 0.24100 0.080800 -0.228000 1.88e-01 2.06e-04
Signaling by FGFR4 32 7.58e-02 2.09e-01 0.24100 0.178000 -0.163000 8.17e-02 1.11e-01
Triglyceride metabolism 24 1.42e-01 3.16e-01 0.24100 0.127000 -0.205000 2.81e-01 8.27e-02
Ribosomal scanning and start codon recognition 58 4.49e-03 2.61e-02 0.24000 0.132000 0.200000 8.18e-02 8.26e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 3.39e-01 5.33e-01 0.24000 0.063100 -0.231000 6.94e-01 1.48e-01
activated TAK1 mediates p38 MAPK activation 23 1.58e-01 3.37e-01 0.24000 0.136000 -0.197000 2.57e-01 1.02e-01
Mitotic Spindle Checkpoint 107 1.75e-04 1.90e-03 0.24000 0.105000 -0.216000 6.16e-02 1.16e-04
NFE2L2 regulating tumorigenic genes 11 3.99e-01 5.87e-01 0.24000 0.234000 -0.052400 1.79e-01 7.64e-01
rRNA processing 213 3.38e-09 1.01e-07 0.23900 0.120000 0.207000 2.52e-03 1.93e-07
VEGFA-VEGFR2 Pathway 92 5.47e-04 4.61e-03 0.23900 0.081700 -0.225000 1.76e-01 1.93e-04
Early SARS-CoV-2 Infection Events 30 7.86e-02 2.15e-01 0.23900 0.018500 -0.238000 8.61e-01 2.41e-02
Senescence-Associated Secretory Phenotype (SASP) 64 5.25e-03 2.93e-02 0.23800 0.230000 -0.064800 1.49e-03 3.70e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 6.44e-02 1.86e-01 0.23800 0.096100 -0.218000 3.32e-01 2.76e-02
Signaling by ALK fusions and activated point mutants 89 4.07e-04 3.64e-03 0.23800 -0.040100 -0.235000 5.13e-01 1.27e-04
Signaling by ALK in cancer 89 4.07e-04 3.64e-03 0.23800 -0.040100 -0.235000 5.13e-01 1.27e-04
PI-3K cascade:FGFR4 11 4.20e-01 6.01e-01 0.23800 0.153000 -0.182000 3.80e-01 2.95e-01
FGFR1 mutant receptor activation 25 1.30e-01 2.98e-01 0.23800 0.062300 -0.229000 5.90e-01 4.72e-02
Downregulation of ERBB2:ERBB3 signaling 12 3.77e-01 5.66e-01 0.23700 -0.067800 0.227000 6.84e-01 1.73e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.98e-04 2.93e-03 0.23700 0.030400 0.235000 6.11e-01 8.03e-05
Pyrimidine salvage 10 4.39e-01 6.17e-01 0.23700 0.233000 -0.045200 2.02e-01 8.05e-01
Nef Mediated CD8 Down-regulation 7 5.71e-01 7.25e-01 0.23700 0.221000 -0.085700 3.12e-01 6.94e-01
Adherens junctions interactions 36 4.13e-02 1.39e-01 0.23700 -0.224000 -0.076800 2.01e-02 4.25e-01
PKR-mediated signaling 67 4.55e-03 2.63e-02 0.23600 0.066800 -0.227000 3.44e-01 1.32e-03
RNA Polymerase III Chain Elongation 18 1.97e-01 3.85e-01 0.23600 0.203000 0.122000 1.36e-01 3.72e-01
Signalling to RAS 19 2.02e-01 3.90e-01 0.23600 0.000833 -0.236000 9.95e-01 7.47e-02
DNA Damage/Telomere Stress Induced Senescence 42 3.88e-02 1.34e-01 0.23600 0.154000 -0.179000 8.38e-02 4.49e-02
Pyroptosis 24 1.18e-01 2.84e-01 0.23600 -0.105000 -0.211000 3.74e-01 7.32e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.89e-01 4.84e-01 0.23600 0.196000 -0.130000 1.74e-01 3.67e-01
Ub-specific processing proteases 153 6.55e-06 1.18e-04 0.23500 0.096400 -0.215000 3.96e-02 4.61e-06
Metalloprotease DUBs 20 2.12e-01 4.00e-01 0.23500 0.117000 -0.204000 3.66e-01 1.14e-01
Cytosolic sulfonation of small molecules 18 2.06e-01 3.91e-01 0.23500 0.217000 0.088800 1.10e-01 5.14e-01
TGF-beta receptor signaling activates SMADs 45 3.04e-02 1.15e-01 0.23500 0.107000 -0.209000 2.14e-01 1.53e-02
A tetrasaccharide linker sequence is required for GAG synthesis 16 2.62e-01 4.53e-01 0.23500 0.012400 0.234000 9.32e-01 1.05e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 1.20e-01 2.87e-01 0.23400 0.219000 -0.083700 4.88e-02 4.52e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 1.24e-01 2.90e-01 0.23400 0.012300 0.234000 9.15e-01 4.27e-02
Translation initiation complex formation 58 5.79e-03 3.14e-02 0.23400 0.131000 0.194000 8.48e-02 1.04e-02
Respiratory Syncytial Virus Infection Pathway 97 3.38e-04 3.15e-03 0.23400 0.001770 -0.234000 9.76e-01 6.67e-05
Peptide hormone metabolism 52 1.20e-02 5.47e-02 0.23400 -0.043100 -0.230000 5.91e-01 4.08e-03
Programmed Cell Death 186 5.89e-07 1.40e-05 0.23400 0.093500 -0.214000 2.78e-02 4.57e-07
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 3.57e-01 5.51e-01 0.23400 -0.061100 -0.226000 7.14e-01 1.76e-01
alpha-linolenic acid (ALA) metabolism 12 3.57e-01 5.51e-01 0.23400 -0.061100 -0.226000 7.14e-01 1.76e-01
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.19e-07 5.69e-06 0.23300 0.076000 0.221000 7.95e-02 3.48e-07
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.20e-01 5.12e-01 0.23300 0.132000 -0.192000 3.76e-01 1.97e-01
GPER1 signaling 38 5.62e-02 1.71e-01 0.23300 0.140000 -0.187000 1.36e-01 4.61e-02
rRNA processing in the nucleus and cytosol 189 9.59e-08 2.59e-06 0.23300 0.078100 0.220000 6.40e-02 1.90e-07
Translation of Structural Proteins 9683701 29 1.09e-01 2.69e-01 0.23300 0.107000 -0.207000 3.20e-01 5.37e-02
Viral mRNA Translation 88 7.25e-04 5.73e-03 0.23300 0.010900 0.233000 8.59e-01 1.62e-04
Eukaryotic Translation Termination 92 5.79e-04 4.86e-03 0.23200 -0.003450 0.232000 9.54e-01 1.17e-04
FGFR1c ligand binding and activation 8 5.06e-01 6.74e-01 0.23200 0.072600 0.221000 7.22e-01 2.80e-01
VLDLR internalisation and degradation 16 2.50e-01 4.38e-01 0.23200 0.203000 0.112000 1.60e-01 4.36e-01
Telomere C-strand synthesis initiation 13 3.54e-01 5.49e-01 0.23200 -0.231000 0.024500 1.50e-01 8.79e-01
HDMs demethylate histones 22 1.55e-01 3.34e-01 0.23200 -0.221000 -0.071600 7.34e-02 5.61e-01
Signaling by EGFR 47 3.03e-02 1.15e-01 0.23200 0.171000 -0.157000 4.31e-02 6.31e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.17e-02 5.35e-02 0.23200 -0.002330 -0.232000 9.76e-01 2.97e-03
Ras activation upon Ca2+ influx through NMDA receptor 15 2.98e-01 4.93e-01 0.23100 -0.231000 -0.000189 1.21e-01 9.99e-01
Gluconeogenesis 19 1.92e-01 3.80e-01 0.23100 -0.168000 -0.159000 2.06e-01 2.31e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 1.34e-02 5.99e-02 0.23100 0.082600 0.216000 3.07e-01 7.75e-03
Signaling by FGFR4 in disease 11 4.10e-01 5.95e-01 0.23100 -0.015400 -0.230000 9.29e-01 1.86e-01
Synthesis of UDP-N-acetyl-glucosamine 8 5.15e-01 6.83e-01 0.23100 0.048300 0.225000 8.13e-01 2.69e-01
CD28 dependent PI3K/Akt signaling 22 1.83e-01 3.68e-01 0.23100 -0.056500 0.224000 6.46e-01 6.96e-02
Signaling by NTRK2 (TRKB) 20 2.18e-01 4.07e-01 0.23000 0.075800 -0.218000 5.57e-01 9.20e-02
L1CAM interactions 99 7.02e-04 5.60e-03 0.23000 0.162000 -0.164000 5.31e-03 4.92e-03
Sensing of DNA Double Strand Breaks 6 6.00e-01 7.49e-01 0.23000 -0.206000 -0.103000 3.83e-01 6.62e-01
RHOC GTPase cycle 71 4.79e-03 2.72e-02 0.23000 0.087500 -0.213000 2.02e-01 1.93e-03
Synthesis, secretion, and deacylation of Ghrelin 11 3.89e-01 5.78e-01 0.23000 -0.132000 -0.188000 4.48e-01 2.79e-01
Thromboxane signalling through TP receptor 20 2.30e-01 4.18e-01 0.23000 0.179000 -0.144000 1.65e-01 2.65e-01
Phosphate bond hydrolysis by NUDT proteins 7 5.69e-01 7.23e-01 0.23000 0.229000 0.015800 2.93e-01 9.42e-01
Transport of the SLBP independent Mature mRNA 35 7.57e-02 2.09e-01 0.23000 -0.126000 0.192000 1.97e-01 4.91e-02
Cap-dependent Translation Initiation 118 6.12e-05 7.68e-04 0.23000 0.055300 0.223000 3.00e-01 2.86e-05
Eukaryotic Translation Initiation 118 6.12e-05 7.68e-04 0.23000 0.055300 0.223000 3.00e-01 2.86e-05
Early Phase of HIV Life Cycle 14 3.45e-01 5.41e-01 0.23000 -0.219000 0.069200 1.56e-01 6.54e-01
Mitotic Prometaphase 192 4.63e-07 1.15e-05 0.22900 0.052200 -0.223000 2.12e-01 9.40e-08
DNA strand elongation 32 7.04e-02 1.98e-01 0.22900 -0.219000 -0.068500 3.21e-02 5.03e-01
Asparagine N-linked glycosylation 284 1.08e-09 3.45e-08 0.22900 0.124000 -0.193000 3.34e-04 2.14e-08
Surfactant metabolism 19 2.50e-01 4.38e-01 0.22900 0.166000 -0.158000 2.11e-01 2.32e-01
Defective C1GALT1C1 causes TNPS 9 4.91e-01 6.60e-01 0.22900 0.003050 -0.229000 9.87e-01 2.34e-01
Acyl chain remodelling of PG 11 4.26e-01 6.05e-01 0.22900 0.030800 -0.227000 8.60e-01 1.92e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 6.00e-01 7.49e-01 0.22900 0.191000 0.127000 4.18e-01 5.91e-01
Mitotic G2-G2/M phases 179 1.23e-06 2.74e-05 0.22900 0.047600 -0.224000 2.72e-01 2.31e-07
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 6.30e-02 1.84e-01 0.22900 0.038300 -0.226000 6.91e-01 1.92e-02
Cholesterol biosynthesis 26 1.37e-01 3.08e-01 0.22900 0.042900 -0.225000 7.05e-01 4.73e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 3.64e-01 5.57e-01 0.22900 0.022600 -0.228000 8.88e-01 1.55e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 1.21e-04 1.35e-03 0.22900 0.064000 0.220000 2.46e-01 6.91e-05
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.53e-01 3.32e-01 0.22900 -0.218000 0.068000 5.89e-02 5.56e-01
ABC transporters in lipid homeostasis 14 3.55e-01 5.50e-01 0.22800 -0.097500 0.207000 5.28e-01 1.81e-01
RAF activation 32 9.12e-02 2.37e-01 0.22800 0.067600 -0.218000 5.08e-01 3.30e-02
Transcriptional regulation by RUNX1 170 4.91e-06 9.16e-05 0.22800 0.128000 -0.188000 4.02e-03 2.25e-05
trans-Golgi Network Vesicle Budding 69 7.09e-03 3.65e-02 0.22700 0.177000 -0.142000 1.09e-02 4.09e-02
Defective GALNT3 causes HFTC 8 5.18e-01 6.85e-01 0.22700 -0.088100 -0.209000 6.66e-01 3.05e-01
Signaling by Insulin receptor 63 1.01e-02 4.77e-02 0.22700 0.209000 -0.087300 4.08e-03 2.31e-01
M Phase 345 1.55e-11 6.78e-10 0.22600 0.081900 -0.211000 8.99e-03 1.57e-11
Innate Immune System 965 9.89e-30 6.33e-27 0.22600 0.105000 -0.201000 3.44e-08 4.65e-26
Pre-NOTCH Transcription and Translation 47 3.35e-02 1.22e-01 0.22600 0.093700 -0.206000 2.67e-01 1.47e-02
G2/M Transition 177 2.00e-06 4.22e-05 0.22600 0.038800 -0.222000 3.73e-01 3.39e-07
Downstream signaling of activated FGFR3 17 3.00e-01 4.94e-01 0.22500 0.135000 -0.180000 3.35e-01 1.98e-01
Regulation of localization of FOXO transcription factors 11 4.03e-01 5.91e-01 0.22500 0.169000 0.148000 3.31e-01 3.94e-01
Signaling by MST1 5 7.02e-01 8.22e-01 0.22500 -0.189000 0.122000 4.64e-01 6.37e-01
DCC mediated attractive signaling 13 4.00e-01 5.88e-01 0.22500 0.181000 -0.133000 2.58e-01 4.06e-01
SUMOylation of SUMOylation proteins 35 8.56e-02 2.26e-01 0.22500 -0.175000 0.141000 7.30e-02 1.49e-01
Miscellaneous transport and binding events 20 2.36e-01 4.23e-01 0.22500 0.210000 -0.081200 1.05e-01 5.30e-01
RUNX3 regulates NOTCH signaling 14 3.18e-01 5.11e-01 0.22500 0.134000 0.180000 3.85e-01 2.43e-01
Transport of the SLBP Dependant Mature mRNA 36 7.88e-02 2.15e-01 0.22500 -0.117000 0.191000 2.23e-01 4.68e-02
Attachment and Entry 9694614 13 3.48e-01 5.43e-01 0.22400 -0.114000 -0.193000 4.75e-01 2.29e-01
UCH proteinases 73 5.74e-03 3.14e-02 0.22400 0.102000 -0.199000 1.30e-01 3.22e-03
PCP/CE pathway 74 5.76e-03 3.14e-02 0.22400 0.139000 -0.176000 3.93e-02 8.79e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.61e-04 1.77e-03 0.22400 0.063200 0.215000 2.50e-01 9.13e-05
Uptake and function of diphtheria toxin 6 6.12e-01 7.57e-01 0.22400 -0.153000 -0.164000 5.17e-01 4.87e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 3.08e-01 5.03e-01 0.22400 -0.055700 -0.217000 7.09e-01 1.46e-01
SUMOylation of immune response proteins 12 4.24e-01 6.03e-01 0.22400 -0.078900 0.209000 6.36e-01 2.09e-01
VEGF binds to VEGFR leading to receptor dimerization 5 6.82e-01 8.10e-01 0.22400 0.223000 0.021900 3.89e-01 9.32e-01
VEGF ligand-receptor interactions 5 6.82e-01 8.10e-01 0.22400 0.223000 0.021900 3.89e-01 9.32e-01
Deactivation of the beta-catenin transactivating complex 36 5.34e-02 1.67e-01 0.22400 -0.154000 -0.162000 1.10e-01 9.20e-02
Erythropoietin activates STAT5 6 6.14e-01 7.59e-01 0.22300 -0.156000 -0.160000 5.09e-01 4.97e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.09e-01 2.69e-01 0.22300 -0.181000 0.131000 7.65e-02 2.01e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.09e-01 2.69e-01 0.22300 -0.181000 0.131000 7.65e-02 2.01e-01
RSV-host interactions 76 2.43e-03 1.62e-02 0.22300 -0.089900 -0.204000 1.75e-01 2.10e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 3.77e-01 5.66e-01 0.22200 0.196000 -0.104000 2.03e-01 4.99e-01
Signaling by WNT 236 6.54e-08 1.79e-06 0.22200 0.074200 -0.210000 4.96e-02 2.92e-08
Chondroitin sulfate/dermatan sulfate metabolism 37 5.39e-02 1.67e-01 0.22200 0.098800 0.199000 2.99e-01 3.64e-02
SUMOylation of ubiquitinylation proteins 39 6.51e-02 1.88e-01 0.22200 -0.082600 0.206000 3.72e-01 2.61e-02
Protein folding 83 3.52e-03 2.18e-02 0.22200 0.149000 -0.165000 1.93e-02 9.52e-03
Nitric oxide stimulates guanylate cyclase 15 3.33e-01 5.27e-01 0.22200 -0.014500 0.221000 9.22e-01 1.38e-01
PI-3K cascade:FGFR2 13 4.06e-01 5.93e-01 0.22100 0.089700 -0.202000 5.75e-01 2.07e-01
G2/M DNA damage checkpoint 66 1.10e-02 5.16e-02 0.22100 0.114000 -0.189000 1.09e-01 7.81e-03
Synthesis of IP2, IP, and Ins in the cytosol 13 3.69e-01 5.60e-01 0.22100 -0.057400 -0.213000 7.20e-01 1.83e-01
Ca2+ pathway 57 1.64e-02 7.05e-02 0.22100 0.024300 -0.219000 7.51e-01 4.17e-03
RHOQ GTPase cycle 54 2.23e-02 9.01e-02 0.22000 0.214000 -0.052300 6.49e-03 5.06e-01
FRS-mediated FGFR1 signaling 15 3.52e-01 5.47e-01 0.22000 0.211000 -0.062400 1.58e-01 6.76e-01
mRNA Editing 8 5.61e-01 7.18e-01 0.22000 0.008970 -0.219000 9.65e-01 2.83e-01
Integration of provirus 9 4.97e-01 6.67e-01 0.21900 -0.192000 -0.106000 3.18e-01 5.82e-01
S Phase 150 2.03e-05 3.27e-04 0.21900 0.002050 -0.219000 9.65e-01 3.54e-06
XBP1(S) activates chaperone genes 44 4.44e-02 1.46e-01 0.21900 0.217000 -0.028400 1.27e-02 7.45e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.19e-01 2.87e-01 0.21900 -0.153000 0.156000 1.34e-01 1.26e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 2.92e-01 4.87e-01 0.21800 0.070400 -0.207000 6.05e-01 1.29e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 2.92e-01 4.87e-01 0.21800 0.070400 -0.207000 6.05e-01 1.29e-01
Chaperonin-mediated protein folding 77 6.34e-03 3.38e-02 0.21800 0.140000 -0.167000 3.40e-02 1.13e-02
Inhibition of Signaling by Overexpressed EGFR 5 7.14e-01 8.29e-01 0.21700 -0.078800 0.203000 7.60e-01 4.33e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 5 7.14e-01 8.29e-01 0.21700 -0.078800 0.203000 7.60e-01 4.33e-01
Selenoamino acid metabolism 115 2.70e-04 2.73e-03 0.21700 0.012100 0.217000 8.23e-01 5.90e-05
Signaling by RAF1 mutants 36 9.50e-02 2.44e-01 0.21700 0.144000 -0.162000 1.34e-01 9.21e-02
Defective pyroptosis 27 1.72e-01 3.55e-01 0.21700 0.149000 -0.157000 1.79e-01 1.58e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 4.84e-01 6.57e-01 0.21700 -0.190000 0.104000 2.75e-01 5.52e-01
Amino acids regulate mTORC1 48 3.19e-02 1.17e-01 0.21600 0.215000 0.024700 9.97e-03 7.67e-01
Meiosis 66 1.27e-02 5.70e-02 0.21600 0.088600 -0.197000 2.13e-01 5.57e-03
GABA receptor activation 35 1.04e-01 2.61e-01 0.21600 0.150000 -0.155000 1.24e-01 1.13e-01
DNA Replication 128 2.10e-04 2.23e-03 0.21600 0.075800 -0.202000 1.39e-01 7.95e-05
Signaling by WNT in cancer 30 1.41e-01 3.14e-01 0.21500 0.097000 -0.192000 3.58e-01 6.86e-02
Gastrulation 73 8.19e-03 4.03e-02 0.21500 0.080200 -0.200000 2.36e-01 3.17e-03
Regulation of TP53 Activity through Methylation 19 2.94e-01 4.89e-01 0.21500 -0.176000 0.123000 1.83e-01 3.54e-01
TCR signaling 110 4.21e-04 3.73e-03 0.21500 -0.025900 -0.213000 6.39e-01 1.11e-04
RIP-mediated NFkB activation via ZBP1 17 3.16e-01 5.10e-01 0.21500 -0.212000 0.035900 1.31e-01 7.97e-01
Signaling by VEGF 99 1.42e-03 1.03e-02 0.21500 0.060600 -0.206000 2.97e-01 3.99e-04
Pyruvate metabolism 44 5.39e-02 1.67e-01 0.21500 0.060400 -0.206000 4.88e-01 1.81e-02
Metabolism of nitric oxide: NOS3 activation and regulation 13 4.09e-01 5.94e-01 0.21400 0.010400 -0.214000 9.48e-01 1.81e-01
Cell Cycle, Mitotic 487 1.07e-14 6.61e-13 0.21400 0.034400 -0.211000 1.94e-01 1.30e-15
Beta-catenin independent WNT signaling 124 3.20e-04 3.03e-03 0.21400 0.083400 -0.197000 1.09e-01 1.48e-04
Signaling by FGFR1 in disease 32 1.20e-01 2.87e-01 0.21400 0.059700 -0.206000 5.59e-01 4.41e-02
RHOH GTPase cycle 33 1.22e-01 2.89e-01 0.21400 0.131000 -0.170000 1.94e-01 9.17e-02
Rev-mediated nuclear export of HIV RNA 35 1.08e-01 2.68e-01 0.21400 -0.135000 0.166000 1.68e-01 8.87e-02
SARS-CoV-2 modulates host translation machinery 49 3.56e-02 1.26e-01 0.21400 -0.014100 0.213000 8.65e-01 9.79e-03
APC-Cdc20 mediated degradation of Nek2A 26 1.93e-01 3.80e-01 0.21400 0.165000 -0.135000 1.45e-01 2.32e-01
Prevention of phagosomal-lysosomal fusion 9 5.54e-01 7.14e-01 0.21300 0.204000 -0.062600 2.89e-01 7.45e-01
NFE2L2 regulating MDR associated enzymes 8 5.87e-01 7.39e-01 0.21300 0.209000 -0.042000 3.06e-01 8.37e-01
Fertilization 12 4.55e-01 6.31e-01 0.21300 -0.205000 0.057700 2.19e-01 7.29e-01
Estrogen-dependent gene expression 96 1.48e-03 1.07e-02 0.21300 0.004780 -0.213000 9.36e-01 3.14e-04
Transcriptional Regulation by VENTX 38 7.59e-02 2.10e-01 0.21200 -0.212000 0.000337 2.36e-02 9.97e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.62e-01 3.43e-01 0.21200 0.010400 -0.212000 9.25e-01 5.67e-02
Downregulation of ERBB4 signaling 8 5.92e-01 7.42e-01 0.21200 0.041100 -0.208000 8.41e-01 3.09e-01
Signaling by ERBB2 ECD mutants 15 3.81e-01 5.71e-01 0.21200 0.068500 -0.200000 6.46e-01 1.79e-01
Vitamin B5 (pantothenate) metabolism 20 2.33e-01 4.19e-01 0.21200 -0.146000 -0.153000 2.58e-01 2.36e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 3.61e-01 5.55e-01 0.21100 0.078400 -0.196000 5.87e-01 1.74e-01
Keratinization 33 1.13e-01 2.75e-01 0.21100 0.210000 -0.022000 3.68e-02 8.27e-01
Germ layer formation at gastrulation 9 5.60e-01 7.17e-01 0.21100 0.055800 -0.204000 7.72e-01 2.90e-01
RNA Polymerase III Transcription Termination 22 2.04e-01 3.91e-01 0.21100 0.167000 0.129000 1.76e-01 2.95e-01
Plasma lipoprotein remodeling 18 2.92e-01 4.87e-01 0.21000 0.207000 0.034900 1.28e-01 7.98e-01
Retrograde transport at the Trans-Golgi-Network 49 3.72e-02 1.30e-01 0.21000 -0.014800 -0.209000 8.57e-01 1.12e-02
Unfolded Protein Response (UPR) 84 4.32e-03 2.55e-02 0.21000 0.208000 -0.025400 9.79e-04 6.87e-01
Other semaphorin interactions 16 3.77e-01 5.66e-01 0.20900 0.163000 -0.131000 2.58e-01 3.64e-01
ER Quality Control Compartment (ERQC) 21 2.80e-01 4.74e-01 0.20900 0.143000 -0.153000 2.58e-01 2.25e-01
Eicosanoids 6 6.94e-01 8.14e-01 0.20900 0.162000 -0.132000 4.92e-01 5.75e-01
Nuclear import of Rev protein 34 1.26e-01 2.93e-01 0.20900 -0.172000 0.119000 8.26e-02 2.32e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 5.99e-01 7.48e-01 0.20800 0.019200 -0.207000 9.25e-01 3.11e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 4.81e-01 6.55e-01 0.20800 0.092800 -0.186000 5.78e-01 2.65e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.40e-03 1.02e-02 0.20700 0.026600 0.205000 6.46e-01 3.88e-04
Cellular response to chemical stress 178 2.73e-05 4.16e-04 0.20700 0.126000 -0.164000 3.63e-03 1.67e-04
Metabolism of non-coding RNA 53 4.38e-02 1.45e-01 0.20600 -0.136000 0.155000 8.65e-02 5.09e-02
snRNP Assembly 53 4.38e-02 1.45e-01 0.20600 -0.136000 0.155000 8.65e-02 5.09e-02
TICAM1-dependent activation of IRF3/IRF7 13 4.24e-01 6.03e-01 0.20500 -0.198000 -0.053300 2.16e-01 7.39e-01
Activation of RAC1 downstream of NMDARs 7 6.44e-01 7.82e-01 0.20500 0.205000 -0.012900 3.49e-01 9.53e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.19e-01 2.87e-01 0.20500 0.181000 -0.096400 6.05e-02 3.17e-01
Mitochondrial calcium ion transport 22 2.24e-01 4.12e-01 0.20500 0.168000 0.117000 1.73e-01 3.41e-01
Factors involved in megakaryocyte development and platelet production 128 4.62e-04 4.02e-03 0.20400 0.055000 -0.197000 2.82e-01 1.22e-04
WNT mediated activation of DVL 8 5.98e-01 7.48e-01 0.20400 0.027200 0.202000 8.94e-01 3.22e-01
Signaling by Retinoic Acid 29 1.61e-01 3.40e-01 0.20400 -0.204000 -0.004980 5.72e-02 9.63e-01
Attenuation phase 22 2.26e-01 4.15e-01 0.20400 -0.154000 -0.133000 2.11e-01 2.79e-01
Interleukin-10 signaling 35 1.33e-01 3.04e-01 0.20400 -0.138000 0.150000 1.57e-01 1.26e-01
Defensins 8 5.90e-01 7.42e-01 0.20400 0.191000 0.071800 3.51e-01 7.25e-01
Interleukin-1 family signaling 127 6.70e-04 5.43e-03 0.20400 0.117000 -0.167000 2.32e-02 1.16e-03
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 3.86e-01 5.74e-01 0.20300 -0.201000 -0.028700 1.78e-01 8.47e-01
Activation of GABAB receptors 29 1.90e-01 3.76e-01 0.20300 0.122000 -0.162000 2.55e-01 1.31e-01
GABA B receptor activation 29 1.90e-01 3.76e-01 0.20300 0.122000 -0.162000 2.55e-01 1.31e-01
Ephrin signaling 17 3.22e-01 5.15e-01 0.20300 -0.121000 -0.163000 3.89e-01 2.45e-01
Activation of Ca-permeable Kainate Receptor 8 6.18e-01 7.60e-01 0.20300 0.033900 -0.200000 8.68e-01 3.28e-01
Ionotropic activity of kainate receptors 8 6.18e-01 7.60e-01 0.20300 0.033900 -0.200000 8.68e-01 3.28e-01
Apoptotic factor-mediated response 19 3.15e-01 5.09e-01 0.20200 0.015300 -0.201000 9.08e-01 1.28e-01
FRS-mediated FGFR2 signaling 15 4.05e-01 5.93e-01 0.20200 0.024900 -0.200000 8.68e-01 1.79e-01
Late endosomal microautophagy 30 1.79e-01 3.63e-01 0.20200 0.091600 -0.180000 3.85e-01 8.84e-02
Pre-NOTCH Expression and Processing 63 2.77e-02 1.07e-01 0.20200 0.098700 -0.176000 1.76e-01 1.59e-02
Interferon gamma signaling 87 3.70e-03 2.27e-02 0.20100 -0.184000 -0.080400 2.96e-03 1.95e-01
Formation of the Editosome 6 6.94e-01 8.14e-01 0.20100 0.201000 0.000884 3.94e-01 9.97e-01
mRNA Editing: C to U Conversion 6 6.94e-01 8.14e-01 0.20100 0.201000 0.000884 3.94e-01 9.97e-01
Negative regulation of FLT3 15 3.76e-01 5.66e-01 0.20100 -0.109000 -0.169000 4.65e-01 2.58e-01
Signaling by RNF43 mutants 7 6.73e-01 8.04e-01 0.20000 0.095500 -0.176000 6.62e-01 4.20e-01
Sphingolipid metabolism 91 6.02e-03 3.24e-02 0.19900 0.182000 -0.082200 2.74e-03 1.76e-01
Signaling by BMP 23 2.26e-01 4.15e-01 0.19900 -0.134000 -0.147000 2.66e-01 2.21e-01
Acyl chain remodelling of PC 19 3.27e-01 5.21e-01 0.19900 0.016700 -0.198000 9.00e-01 1.35e-01
Intraflagellar transport 47 5.04e-02 1.61e-01 0.19900 -0.174000 -0.095800 3.88e-02 2.56e-01
Protein lipoylation 10 5.28e-01 6.91e-01 0.19900 -0.111000 -0.165000 5.44e-01 3.66e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.66e-01 3.46e-01 0.19900 0.143000 0.137000 1.89e-01 2.08e-01
Pregnenolone biosynthesis 10 5.76e-01 7.29e-01 0.19900 -0.168000 0.105000 3.57e-01 5.64e-01
Nonhomologous End-Joining (NHEJ) 40 1.07e-01 2.67e-01 0.19800 0.078800 -0.182000 3.88e-01 4.64e-02
Tryptophan catabolism 12 4.66e-01 6.42e-01 0.19800 -0.145000 -0.135000 3.85e-01 4.19e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 6.43e-01 7.80e-01 0.19700 -0.121000 -0.156000 5.80e-01 4.76e-01
IL-6-type cytokine receptor ligand interactions 12 5.23e-01 6.88e-01 0.19700 -0.126000 0.152000 4.51e-01 3.63e-01
Cell Cycle 609 1.95e-15 1.44e-13 0.19700 0.029000 -0.195000 2.21e-01 2.20e-16
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 3.52e-01 5.47e-01 0.19700 -0.197000 0.008750 1.49e-01 9.49e-01
Influenza Viral RNA Transcription and Replication 135 5.19e-04 4.43e-03 0.19700 -0.042200 0.192000 3.97e-01 1.17e-04
CD209 (DC-SIGN) signaling 20 3.10e-01 5.06e-01 0.19600 -0.196000 -0.005650 1.28e-01 9.65e-01
TRAF6 mediated IRF7 activation 15 3.90e-01 5.79e-01 0.19600 -0.152000 -0.124000 3.07e-01 4.05e-01
Glycogen storage diseases 13 4.70e-01 6.46e-01 0.19600 0.196000 0.001080 2.21e-01 9.95e-01
Blood group systems biosynthesis 16 3.72e-01 5.62e-01 0.19600 0.101000 0.167000 4.83e-01 2.46e-01
FRS-mediated FGFR4 signaling 13 4.91e-01 6.60e-01 0.19600 0.068300 -0.183000 6.70e-01 2.52e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 1.20e-01 2.87e-01 0.19500 0.140000 -0.136000 1.24e-01 1.37e-01
Signaling by RAS mutants 40 1.20e-01 2.87e-01 0.19500 0.140000 -0.136000 1.24e-01 1.37e-01
Signaling by moderate kinase activity BRAF mutants 40 1.20e-01 2.87e-01 0.19500 0.140000 -0.136000 1.24e-01 1.37e-01
Signaling downstream of RAS mutants 40 1.20e-01 2.87e-01 0.19500 0.140000 -0.136000 1.24e-01 1.37e-01
IKK complex recruitment mediated by RIP1 23 2.80e-01 4.74e-01 0.19500 0.044800 -0.190000 7.10e-01 1.15e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 74 1.97e-02 8.17e-02 0.19500 0.108000 -0.162000 1.07e-01 1.57e-02
Amino acid transport across the plasma membrane 24 2.71e-01 4.67e-01 0.19500 0.182000 -0.070200 1.23e-01 5.52e-01
Sialic acid metabolism 27 1.92e-01 3.79e-01 0.19500 -0.092100 -0.172000 4.08e-01 1.22e-01
Pre-NOTCH Processing in Golgi 18 3.57e-01 5.51e-01 0.19500 0.001100 -0.195000 9.94e-01 1.52e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 2.14e-01 4.01e-01 0.19500 -0.125000 -0.149000 2.78e-01 1.97e-01
Impaired BRCA2 binding to RAD51 35 1.20e-01 2.87e-01 0.19500 -0.083000 -0.176000 3.95e-01 7.16e-02
Suppression of phagosomal maturation 12 5.31e-01 6.93e-01 0.19400 0.112000 -0.159000 5.00e-01 3.41e-01
Signaling by FGFR3 in disease 14 4.77e-01 6.51e-01 0.19400 0.106000 -0.163000 4.93e-01 2.91e-01
Regulated Necrosis 55 4.23e-02 1.42e-01 0.19300 -0.024400 -0.192000 7.54e-01 1.38e-02
TP53 Regulates Metabolic Genes 77 1.85e-02 7.78e-02 0.19300 0.140000 -0.134000 3.41e-02 4.23e-02
RHOF GTPase cycle 38 1.35e-01 3.04e-01 0.19300 0.081500 -0.175000 3.85e-01 6.17e-02
Glutamate Neurotransmitter Release Cycle 20 3.10e-01 5.06e-01 0.19300 -0.186000 -0.050600 1.49e-01 6.95e-01
Transferrin endocytosis and recycling 26 2.52e-01 4.41e-01 0.19300 0.179000 -0.071000 1.14e-01 5.31e-01
Downstream TCR signaling 89 6.68e-03 3.49e-02 0.19300 -0.008630 -0.193000 8.88e-01 1.69e-03
Class I peroxisomal membrane protein import 20 3.06e-01 5.01e-01 0.19300 -0.177000 -0.075800 1.70e-01 5.57e-01
Notch-HLH transcription pathway 28 2.37e-01 4.23e-01 0.19200 -0.146000 0.126000 1.83e-01 2.48e-01
Hedgehog ‘off’ state 90 7.97e-03 4.00e-02 0.19200 0.043200 -0.187000 4.78e-01 2.11e-03
Regulation of TP53 Activity through Acetylation 29 2.25e-01 4.14e-01 0.19200 -0.112000 0.156000 2.95e-01 1.46e-01
Protein-protein interactions at synapses 54 6.27e-02 1.84e-01 0.19200 -0.156000 0.112000 4.78e-02 1.53e-01
Adaptive Immune System 763 1.83e-17 1.85e-15 0.19200 0.074700 -0.177000 4.47e-04 1.03e-16
SHC-mediated cascade:FGFR3 10 5.98e-01 7.48e-01 0.19200 0.101000 -0.163000 5.79e-01 3.73e-01
Clathrin-mediated endocytosis 127 1.63e-03 1.16e-02 0.19100 0.145000 -0.124000 4.65e-03 1.57e-02
Viral Messenger RNA Synthesis 44 1.09e-01 2.69e-01 0.19100 -0.140000 0.130000 1.08e-01 1.37e-01
Zinc influx into cells by the SLC39 gene family 9 6.31e-01 7.71e-01 0.19100 0.169000 -0.087600 3.80e-01 6.49e-01
SLBP independent Processing of Histone Pre-mRNAs 10 5.93e-01 7.43e-01 0.19000 -0.053500 0.183000 7.70e-01 3.17e-01
Caspase activation via Death Receptors in the presence of ligand 16 4.15e-01 5.98e-01 0.19000 -0.190000 -0.011800 1.89e-01 9.35e-01
Downstream signaling of activated FGFR2 20 3.50e-01 5.45e-01 0.19000 0.042300 -0.185000 7.43e-01 1.52e-01
Gap junction degradation 11 5.76e-01 7.29e-01 0.19000 0.119000 -0.148000 4.94e-01 3.95e-01
Signaling by LTK 10 5.64e-01 7.19e-01 0.19000 -0.177000 -0.068500 3.33e-01 7.08e-01
ERBB2 Regulates Cell Motility 10 5.84e-01 7.36e-01 0.18900 -0.004150 0.189000 9.82e-01 3.00e-01
Metabolism of Angiotensinogen to Angiotensins 12 5.20e-01 6.86e-01 0.18900 -0.013200 -0.188000 9.37e-01 2.58e-01
Synthesis of PIPs at the plasma membrane 52 5.85e-02 1.77e-01 0.18900 -0.021300 -0.187000 7.90e-01 1.93e-02
Formation of definitive endoderm 8 6.59e-01 7.93e-01 0.18800 0.186000 -0.030400 3.62e-01 8.82e-01
ZBP1(DAI) mediated induction of type I IFNs 20 3.54e-01 5.49e-01 0.18800 -0.185000 0.032300 1.51e-01 8.03e-01
Heme degradation 10 5.68e-01 7.23e-01 0.18800 0.171000 0.078200 3.49e-01 6.68e-01
RNA Polymerase I Transcription Initiation 47 9.78e-02 2.50e-01 0.18800 -0.100000 0.159000 2.34e-01 5.91e-02
MAPK family signaling cascades 259 2.15e-06 4.48e-05 0.18800 0.054900 -0.180000 1.28e-01 6.25e-07
NS1 Mediated Effects on Host Pathways 40 1.40e-01 3.13e-01 0.18800 -0.153000 0.109000 9.47e-02 2.31e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 2.54e-01 4.44e-01 0.18800 0.123000 -0.142000 2.60e-01 1.93e-01
Sphingolipid catabolism 11 5.61e-01 7.18e-01 0.18800 0.187000 -0.013100 2.82e-01 9.40e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 7.66e-02 2.11e-01 0.18800 0.177000 -0.060500 2.83e-02 4.55e-01
Downstream signaling of activated FGFR4 18 4.08e-01 5.94e-01 0.18700 0.075600 -0.171000 5.79e-01 2.08e-01
Myoclonic epilepsy of Lafora 8 6.74e-01 8.04e-01 0.18700 0.165000 -0.087600 4.18e-01 6.68e-01
Signaling by TGF-beta Receptor Complex 90 1.23e-02 5.54e-02 0.18700 0.094900 -0.161000 1.20e-01 8.25e-03
Alpha-protein kinase 1 signaling pathway 11 5.62e-01 7.18e-01 0.18700 0.006420 -0.187000 9.71e-01 2.83e-01
HDL remodeling 6 7.27e-01 8.39e-01 0.18700 0.007920 0.187000 9.73e-01 4.28e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.17e-01 4.05e-01 0.18700 0.118000 0.144000 2.88e-01 1.94e-01
Downregulation of TGF-beta receptor signaling 26 2.87e-01 4.82e-01 0.18600 0.116000 -0.145000 3.06e-01 2.01e-01
Activation of gene expression by SREBF (SREBP) 42 9.92e-02 2.52e-01 0.18500 -0.080500 -0.167000 3.66e-01 6.11e-02
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 6.03e-02 1.80e-01 0.18500 0.135000 -0.127000 7.36e-02 9.06e-02
TRIF-mediated programmed cell death 9 6.18e-01 7.61e-01 0.18500 -0.179000 -0.045400 3.53e-01 8.14e-01
Transcriptional Regulation by NPAS4 27 2.42e-01 4.29e-01 0.18500 -0.025400 -0.183000 8.19e-01 1.00e-01
Activation of kainate receptors upon glutamate binding 25 3.03e-01 4.97e-01 0.18400 0.084000 -0.164000 4.67e-01 1.57e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 5.79e-01 7.31e-01 0.18400 -0.031600 0.181000 8.56e-01 2.98e-01
HSF1 activation 25 2.55e-01 4.46e-01 0.18400 -0.159000 -0.093000 1.69e-01 4.21e-01
SUMOylation of DNA methylation proteins 16 4.66e-01 6.42e-01 0.18400 -0.165000 0.082000 2.54e-01 5.70e-01
PKA activation 15 4.86e-01 6.58e-01 0.18400 0.069900 -0.170000 6.39e-01 2.54e-01
RHOU GTPase cycle 40 1.23e-01 2.90e-01 0.18400 -0.031600 -0.181000 7.30e-01 4.75e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.77e-01 7.29e-01 0.18400 -0.142000 -0.117000 4.38e-01 5.22e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 7.44e-01 8.51e-01 0.18400 0.036000 -0.180000 8.78e-01 4.45e-01
O-glycosylation of TSR domain-containing proteins 25 2.84e-01 4.78e-01 0.18400 -0.010400 0.183000 9.28e-01 1.13e-01
Interactions of Rev with host cellular proteins 37 1.78e-01 3.63e-01 0.18400 -0.135000 0.124000 1.55e-01 1.91e-01
TNFs bind their physiological receptors 24 2.81e-01 4.74e-01 0.18300 -0.176000 -0.053100 1.37e-01 6.53e-01
CLEC7A (Dectin-1) signaling 85 1.61e-02 6.92e-02 0.18300 0.041500 -0.178000 5.08e-01 4.50e-03
Nephron development 5 7.63e-01 8.63e-01 0.18300 -0.105000 -0.150000 6.85e-01 5.62e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 4.18e-13 2.11e-11 0.18300 0.073300 -0.167000 1.85e-03 1.21e-12
Signaling by Rho GTPases 603 7.66e-13 3.68e-11 0.18300 0.067300 -0.170000 4.78e-03 1.09e-12
Synthesis of DNA 108 4.67e-03 2.68e-02 0.18200 0.007660 -0.182000 8.91e-01 1.06e-03
Bile acid and bile salt metabolism 28 2.31e-01 4.19e-01 0.18200 -0.061100 -0.171000 5.76e-01 1.17e-01
G beta:gamma signalling through PLC beta 17 4.57e-01 6.32e-01 0.18200 0.108000 -0.147000 4.43e-01 2.95e-01
Presynaptic function of Kainate receptors 17 4.57e-01 6.32e-01 0.18200 0.108000 -0.147000 4.43e-01 2.95e-01
Laminin interactions 25 3.13e-01 5.07e-01 0.18200 0.160000 -0.086700 1.67e-01 4.53e-01
Regulation of PLK1 Activity at G2/M Transition 87 1.16e-02 5.32e-02 0.18200 -0.038200 -0.178000 5.38e-01 4.20e-03
Post-translational protein phosphorylation 67 4.37e-02 1.45e-01 0.18200 0.072800 -0.166000 3.03e-01 1.85e-02
Synaptic adhesion-like molecules 14 5.27e-01 6.91e-01 0.18200 -0.134000 0.123000 3.87e-01 4.26e-01
PKA activation in glucagon signalling 14 5.13e-01 6.81e-01 0.18100 0.047900 -0.175000 7.56e-01 2.57e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 3.34e-01 5.28e-01 0.18100 0.170000 0.062100 1.76e-01 6.22e-01
Neurodegenerative Diseases 21 3.34e-01 5.28e-01 0.18100 0.170000 0.062100 1.76e-01 6.22e-01
SHC-mediated cascade:FGFR1 13 5.29e-01 6.91e-01 0.18100 0.181000 -0.014900 2.59e-01 9.26e-01
Vitamin C (ascorbate) metabolism 8 6.56e-01 7.92e-01 0.18100 -0.162000 -0.081100 4.27e-01 6.91e-01
Interleukin-1 signaling 99 1.11e-02 5.18e-02 0.18100 0.098000 -0.152000 9.22e-02 9.11e-03
RIPK1-mediated regulated necrosis 31 2.29e-01 4.17e-01 0.18100 0.037800 -0.177000 7.15e-01 8.89e-02
Regulation of necroptotic cell death 31 2.29e-01 4.17e-01 0.18100 0.037800 -0.177000 7.15e-01 8.89e-02
Cell recruitment (pro-inflammatory response) 25 3.12e-01 5.06e-01 0.18000 -0.055500 0.171000 6.31e-01 1.38e-01
Purinergic signaling in leishmaniasis infection 25 3.12e-01 5.06e-01 0.18000 -0.055500 0.171000 6.31e-01 1.38e-01
Synthesis of Dolichyl-phosphate 6 7.63e-01 8.63e-01 0.18000 0.106000 -0.146000 6.54e-01 5.37e-01
Signaling by Hedgehog 119 4.01e-03 2.43e-02 0.18000 0.049800 -0.173000 3.48e-01 1.15e-03
Phosphate bond hydrolysis by NTPDase proteins 5 7.72e-01 8.67e-01 0.17900 -0.160000 -0.082000 5.37e-01 7.51e-01
Defective Intrinsic Pathway for Apoptosis 24 2.87e-01 4.82e-01 0.17900 0.105000 0.145000 3.72e-01 2.20e-01
HSF1-dependent transactivation 28 2.67e-01 4.61e-01 0.17900 -0.177000 0.024100 1.05e-01 8.25e-01
Semaphorin interactions 56 8.42e-02 2.24e-01 0.17800 0.140000 -0.110000 6.91e-02 1.54e-01
Membrane binding and targetting of GAG proteins 13 5.39e-01 6.99e-01 0.17800 0.011000 -0.178000 9.45e-01 2.67e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.39e-01 6.99e-01 0.17800 0.011000 -0.178000 9.45e-01 2.67e-01
Deadenylation of mRNA 22 3.74e-01 5.65e-01 0.17800 0.082300 -0.158000 5.04e-01 1.99e-01
Mitochondrial protein import 63 4.07e-02 1.38e-01 0.17800 0.088300 0.154000 2.25e-01 3.43e-02
MAPK1/MAPK3 signaling 227 4.12e-05 5.70e-04 0.17800 0.067300 -0.164000 8.06e-02 1.99e-05
G beta:gamma signalling through PI3Kgamma 22 3.83e-01 5.72e-01 0.17700 0.128000 -0.123000 3.00e-01 3.18e-01
Signaling by NOTCH 173 4.57e-04 3.99e-03 0.17700 0.065100 -0.165000 1.40e-01 1.84e-04
C-type lectin receptors (CLRs) 116 4.56e-03 2.63e-02 0.17700 0.015600 -0.176000 7.72e-01 1.03e-03
SHC-mediated cascade:FGFR2 13 5.31e-01 6.92e-01 0.17700 -0.033700 -0.174000 8.33e-01 2.78e-01
Cristae formation 33 2.17e-01 4.05e-01 0.17700 0.176000 -0.021400 8.06e-02 8.31e-01
ESR-mediated signaling 157 8.70e-04 6.64e-03 0.17700 0.051300 -0.169000 2.67e-01 2.49e-04
Loss of Function of TGFBR1 in Cancer 7 7.30e-01 8.40e-01 0.17700 0.052400 -0.169000 8.10e-01 4.39e-01
Deubiquitination 225 5.24e-05 6.79e-04 0.17700 0.072500 -0.161000 6.10e-02 3.15e-05
AURKA Activation by TPX2 72 3.28e-02 1.20e-01 0.17600 -0.020600 -0.175000 7.63e-01 1.04e-02
Receptor-type tyrosine-protein phosphatases 11 6.07e-01 7.53e-01 0.17600 -0.031000 0.173000 8.59e-01 3.20e-01
SUMOylation of chromatin organization proteins 57 8.58e-02 2.26e-01 0.17600 -0.149000 0.093300 5.21e-02 2.23e-01
TNFR1-induced proapoptotic signaling 24 3.22e-01 5.15e-01 0.17600 -0.175000 -0.017500 1.38e-01 8.82e-01
Chaperone Mediated Autophagy 20 4.26e-01 6.05e-01 0.17500 0.135000 -0.112000 2.97e-01 3.86e-01
SARS-CoV-1 activates/modulates innate immune responses 40 1.41e-01 3.14e-01 0.17500 -0.161000 -0.069900 7.88e-02 4.44e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.43e-01 3.16e-01 0.17500 -0.062100 -0.164000 4.97e-01 7.30e-02
RUNX3 Regulates Immune Response and Cell Migration 5 7.90e-01 8.77e-01 0.17500 -0.022100 -0.174000 9.32e-01 5.01e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.63e-01 3.43e-01 0.17500 -0.076800 0.157000 3.89e-01 7.78e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9 6.39e-01 7.78e-01 0.17500 -0.142000 -0.103000 4.62e-01 5.94e-01
Interleukin-7 signaling 21 3.70e-01 5.61e-01 0.17500 -0.027700 -0.173000 8.26e-01 1.71e-01
Cardiac conduction 86 1.81e-02 7.64e-02 0.17500 -0.015100 -0.174000 8.09e-01 5.22e-03
Metabolism of steroids 120 4.27e-03 2.53e-02 0.17500 0.009290 -0.175000 8.60e-01 9.58e-04
Class I MHC mediated antigen processing & presentation 343 4.75e-07 1.17e-05 0.17400 0.072000 -0.159000 2.21e-02 4.33e-07
Muscle contraction 140 2.31e-03 1.57e-02 0.17400 0.050900 -0.166000 2.99e-01 6.77e-04
Inactivation of APC/C via direct inhibition of the APC/C complex 21 4.14e-01 5.98e-01 0.17400 0.117000 -0.129000 3.52e-01 3.08e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 4.14e-01 5.98e-01 0.17400 0.117000 -0.129000 3.52e-01 3.08e-01
Oxidative Stress Induced Senescence 77 3.71e-02 1.30e-01 0.17400 0.071400 -0.159000 2.79e-01 1.61e-02
AKT phosphorylates targets in the cytosol 14 5.23e-01 6.88e-01 0.17400 0.016000 0.173000 9.17e-01 2.62e-01
Phospholipase C-mediated cascade; FGFR2 8 6.92e-01 8.14e-01 0.17400 -0.174000 -0.008360 3.95e-01 9.67e-01
DAP12 interactions 39 1.95e-01 3.83e-01 0.17400 0.113000 -0.132000 2.22e-01 1.54e-01
Immune System 1824 3.03e-32 2.91e-29 0.17400 0.053800 -0.165000 1.44e-04 1.32e-31
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.68e-01 5.59e-01 0.17300 0.137000 -0.106000 2.47e-01 3.67e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.63e-01 3.43e-01 0.17300 -0.070700 0.158000 4.23e-01 7.39e-02
SUMOylation of RNA binding proteins 47 1.43e-01 3.16e-01 0.17300 -0.105000 0.137000 2.13e-01 1.04e-01
NOTCH2 intracellular domain regulates transcription 11 6.34e-01 7.73e-01 0.17300 -0.110000 0.133000 5.28e-01 4.44e-01
Diseases of carbohydrate metabolism 29 2.46e-01 4.33e-01 0.17200 0.126000 0.118000 2.41e-01 2.72e-01
Phospholipase C-mediated cascade; FGFR4 6 7.79e-01 8.71e-01 0.17200 -0.146000 0.092100 5.37e-01 6.96e-01
PPARA activates gene expression 105 6.53e-03 3.44e-02 0.17200 -0.101000 -0.140000 7.43e-02 1.35e-02
Aryl hydrocarbon receptor signalling 6 7.66e-01 8.65e-01 0.17200 -0.172000 0.007640 4.66e-01 9.74e-01
Rab regulation of trafficking 122 5.76e-03 3.14e-02 0.17200 0.056600 -0.163000 2.81e-01 1.92e-03
Processing of DNA double-strand break ends 69 5.55e-02 1.69e-01 0.17200 0.070100 -0.157000 3.14e-01 2.40e-02
PLC beta mediated events 39 1.69e-01 3.51e-01 0.17200 -0.170000 -0.025000 6.60e-02 7.87e-01
Transcriptional regulation by RUNX2 87 2.63e-02 1.02e-01 0.17200 0.069200 -0.157000 2.64e-01 1.12e-02
tRNA modification in the nucleus and cytosol 43 1.71e-01 3.53e-01 0.17200 -0.096600 0.142000 2.73e-01 1.08e-01
Peptide ligand-binding receptors 98 1.32e-02 5.90e-02 0.17200 0.172000 -0.001560 3.33e-03 9.79e-01
RAF/MAP kinase cascade 222 1.02e-04 1.17e-03 0.17200 0.068600 -0.157000 7.82e-02 5.41e-05
Cellular response to starvation 148 9.28e-04 7.05e-03 0.17100 0.088100 0.147000 6.44e-02 2.01e-03
Role of second messengers in netrin-1 signaling 6 7.54e-01 8.59e-01 0.17100 -0.155000 -0.072900 5.11e-01 7.57e-01
PKA-mediated phosphorylation of CREB 17 4.67e-01 6.43e-01 0.17100 -0.019600 -0.170000 8.89e-01 2.26e-01
Regulation of PTEN gene transcription 59 8.79e-02 2.30e-01 0.17000 -0.157000 0.066500 3.71e-02 3.77e-01
CASP8 activity is inhibited 11 6.01e-01 7.49e-01 0.17000 -0.156000 -0.068000 3.70e-01 6.96e-01
Dimerization of procaspase-8 11 6.01e-01 7.49e-01 0.17000 -0.156000 -0.068000 3.70e-01 6.96e-01
Regulation by c-FLIP 11 6.01e-01 7.49e-01 0.17000 -0.156000 -0.068000 3.70e-01 6.96e-01
Macroautophagy 128 5.76e-03 3.14e-02 0.17000 0.144000 -0.089600 4.76e-03 7.99e-02
Defective RIPK1-mediated regulated necrosis 7 7.24e-01 8.37e-01 0.17000 -0.156000 -0.067100 4.74e-01 7.59e-01
Interferon Signaling 237 1.96e-05 3.23e-04 0.17000 -0.076700 -0.151000 4.19e-02 6.05e-05
Autophagy 142 3.53e-03 2.18e-02 0.16900 0.136000 -0.101000 5.03e-03 3.86e-02
Malate-aspartate shuttle 8 7.09e-01 8.26e-01 0.16900 -0.169000 0.005690 4.07e-01 9.78e-01
Nicotinate metabolism 26 3.14e-01 5.09e-01 0.16900 -0.035200 -0.165000 7.56e-01 1.44e-01
Regulation of lipid metabolism by PPARalpha 107 7.01e-03 3.62e-02 0.16900 -0.114000 -0.125000 4.21e-02 2.53e-02
Nuclear Envelope (NE) Reassembly 68 6.74e-02 1.92e-01 0.16900 0.134000 -0.103000 5.64e-02 1.41e-01
Regulation of NFE2L2 gene expression 8 7.18e-01 8.32e-01 0.16900 -0.163000 0.042800 4.24e-01 8.34e-01
PKMTs methylate histone lysines 42 1.57e-01 3.35e-01 0.16900 -0.166000 -0.030800 6.29e-02 7.30e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 6.93e-01 8.14e-01 0.16900 -0.083500 -0.147000 6.82e-01 4.73e-01
Metabolic disorders of biological oxidation enzymes 23 3.65e-01 5.57e-01 0.16800 0.166000 0.026800 1.68e-01 8.24e-01
RUNX2 regulates bone development 21 4.34e-01 6.13e-01 0.16800 0.077000 -0.149000 5.41e-01 2.36e-01
TP53 Regulates Transcription of Cell Death Genes 42 1.93e-01 3.81e-01 0.16800 -0.099200 0.135000 2.66e-01 1.29e-01
Ion transport by P-type ATPases 41 1.55e-01 3.34e-01 0.16800 -0.094400 -0.139000 2.96e-01 1.25e-01
NCAM1 interactions 26 3.61e-01 5.55e-01 0.16700 -0.083800 0.145000 4.60e-01 2.02e-01
Activation of BH3-only proteins 29 2.69e-01 4.65e-01 0.16700 0.100000 0.133000 3.49e-01 2.14e-01
Cilium Assembly 186 2.31e-04 2.42e-03 0.16700 -0.122000 -0.114000 4.13e-03 7.38e-03
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 6.78e-01 8.07e-01 0.16700 0.034700 0.163000 8.57e-01 3.97e-01
Costimulation by the CD28 family 74 4.33e-02 1.44e-01 0.16600 -0.165000 -0.021300 1.42e-02 7.52e-01
Ribavirin ADME 11 6.25e-01 7.67e-01 0.16600 -0.026600 -0.164000 8.79e-01 3.46e-01
Formation of annular gap junctions 10 6.80e-01 8.09e-01 0.16600 0.085200 -0.142000 6.41e-01 4.36e-01
Antiviral mechanism by IFN-stimulated genes 140 3.13e-03 2.00e-02 0.16600 0.002540 -0.166000 9.59e-01 7.03e-04
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 4.06e-01 5.93e-01 0.16600 0.155000 -0.059700 2.00e-01 6.20e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 8.72e-03 4.22e-02 0.16600 0.010100 0.165000 8.53e-01 2.29e-03
Nonsense-Mediated Decay (NMD) 114 8.72e-03 4.22e-02 0.16600 0.010100 0.165000 8.53e-01 2.29e-03
tRNA processing 128 4.44e-03 2.58e-02 0.16500 0.042500 0.159000 4.07e-01 1.88e-03
Assembly Of The HIV Virion 15 5.69e-01 7.23e-01 0.16400 0.099400 -0.131000 5.05e-01 3.80e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 4.75e-01 6.49e-01 0.16400 0.120000 -0.112000 3.53e-01 3.87e-01
TNFR2 non-canonical NF-kB pathway 83 3.25e-02 1.19e-01 0.16400 -0.024300 -0.162000 7.02e-01 1.07e-02
Cardiogenesis 13 6.17e-01 7.60e-01 0.16300 -0.133000 0.094600 4.06e-01 5.55e-01
Signaling by TGFB family members 137 4.73e-03 2.70e-02 0.16300 0.021100 -0.162000 6.71e-01 1.08e-03
Trafficking of GluR2-containing AMPA receptors 11 6.66e-01 7.98e-01 0.16300 0.131000 -0.097200 4.53e-01 5.77e-01
RND3 GTPase cycle 35 2.66e-01 4.60e-01 0.16300 0.057400 -0.152000 5.57e-01 1.19e-01
tRNA processing in the nucleus 59 1.13e-01 2.76e-01 0.16200 -0.080900 0.141000 2.82e-01 6.15e-02
NGF-stimulated transcription 32 2.96e-01 4.90e-01 0.16200 -0.156000 0.043300 1.26e-01 6.72e-01
Azathioprine ADME 20 4.36e-01 6.15e-01 0.16200 -0.047200 -0.155000 7.15e-01 2.29e-01
Downregulation of ERBB2 signaling 24 4.01e-01 5.89e-01 0.16200 -0.042500 0.156000 7.19e-01 1.84e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 5.50e-01 7.11e-01 0.16200 0.104000 0.124000 5.02e-01 4.21e-01
G-protein mediated events 43 1.69e-01 3.51e-01 0.16200 -0.154000 -0.049500 8.04e-02 5.74e-01
Downstream signaling of activated FGFR1 22 4.50e-01 6.26e-01 0.16200 0.127000 -0.101000 3.04e-01 4.14e-01
Signaling by Hippo 18 5.18e-01 6.85e-01 0.16100 0.141000 -0.077800 3.00e-01 5.68e-01
Glutathione conjugation 26 3.33e-01 5.27e-01 0.16100 -0.109000 -0.119000 3.37e-01 2.94e-01
VEGFR2 mediated cell proliferation 18 4.89e-01 6.60e-01 0.16100 -0.014900 -0.160000 9.13e-01 2.39e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 4.16e-01 6.00e-01 0.16100 0.142000 -0.075600 2.28e-01 5.22e-01
Basigin interactions 21 4.54e-01 6.31e-01 0.16100 0.156000 -0.039500 2.16e-01 7.54e-01
Fatty acids 6 7.77e-01 8.70e-01 0.16100 -0.124000 -0.101000 5.97e-01 6.67e-01
Cellular responses to mechanical stimuli 82 5.39e-02 1.67e-01 0.16000 0.122000 -0.105000 5.70e-02 1.02e-01
Response of endothelial cells to shear stress 82 5.39e-02 1.67e-01 0.16000 0.122000 -0.105000 5.70e-02 1.02e-01
Cell-cell junction organization 55 1.31e-01 2.99e-01 0.16000 -0.154000 0.044900 4.84e-02 5.65e-01
The canonical retinoid cycle in rods (twilight vision) 9 7.07e-01 8.25e-01 0.16000 -0.004640 0.160000 9.81e-01 4.06e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 3.46e-01 5.41e-01 0.16000 0.109000 -0.116000 3.00e-01 2.70e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 4.23e-01 6.03e-01 0.15900 0.157000 0.023500 2.01e-01 8.49e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 7.24e-01 8.37e-01 0.15900 0.147000 0.061800 4.73e-01 7.62e-01
Triglyceride biosynthesis 9 6.91e-01 8.14e-01 0.15900 0.125000 0.098500 5.18e-01 6.09e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.19e-01 2.86e-01 0.15900 0.112000 0.112000 1.62e-01 1.61e-01
Hyaluronan metabolism 15 5.58e-01 7.15e-01 0.15800 0.028600 0.156000 8.48e-01 2.96e-01
Pexophagy 10 6.96e-01 8.16e-01 0.15800 -0.153000 0.041300 4.03e-01 8.21e-01
Signaling by TGFBR3 39 2.06e-01 3.91e-01 0.15800 -0.116000 -0.107000 2.10e-01 2.47e-01
Regulation of CDH11 function 9 7.04e-01 8.24e-01 0.15700 -0.149000 -0.049500 4.39e-01 7.97e-01
Dissolution of Fibrin Clot 12 6.51e-01 7.88e-01 0.15700 -0.038300 0.152000 8.18e-01 3.61e-01
GAB1 signalosome 14 6.21e-01 7.63e-01 0.15600 0.094800 -0.124000 5.39e-01 4.20e-01
ECM proteoglycans 45 1.83e-01 3.68e-01 0.15600 0.155000 0.022900 7.25e-02 7.91e-01
PIWI-interacting RNA (piRNA) biogenesis 23 4.06e-01 5.93e-01 0.15600 -0.074700 -0.137000 5.35e-01 2.55e-01
Ion homeostasis 40 2.14e-01 4.03e-01 0.15600 -0.050800 -0.148000 5.78e-01 1.06e-01
FGFR3 ligand binding and activation 5 8.27e-01 8.98e-01 0.15600 -0.039700 -0.151000 8.78e-01 5.59e-01
FGFR3c ligand binding and activation 5 8.27e-01 8.98e-01 0.15600 -0.039700 -0.151000 8.78e-01 5.59e-01
Ca-dependent events 29 3.20e-01 5.12e-01 0.15500 -0.119000 -0.099800 2.66e-01 3.52e-01
Glycosphingolipid catabolism 31 3.00e-01 4.94e-01 0.15500 0.123000 0.093800 2.36e-01 3.66e-01
Influenza Infection 154 4.68e-03 2.68e-02 0.15500 -0.027800 0.152000 5.52e-01 1.12e-03
Androgen biosynthesis 5 8.30e-01 8.99e-01 0.15400 -0.032600 -0.151000 9.00e-01 5.59e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 8.75e-02 2.29e-01 0.15400 -0.060200 0.142000 3.77e-01 3.69e-02
Defective B3GALTL causes PpS 24 4.20e-01 6.01e-01 0.15400 0.006850 0.154000 9.54e-01 1.91e-01
Transcriptional regulation of brown and beige adipocyte differentiation 23 4.42e-01 6.19e-01 0.15400 -0.154000 0.010000 2.01e-01 9.34e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 23 4.42e-01 6.19e-01 0.15400 -0.154000 0.010000 2.01e-01 9.34e-01
Signaling by NTRK3 (TRKC) 15 5.62e-01 7.18e-01 0.15400 -0.119000 -0.097600 4.26e-01 5.13e-01
Regulation of BACH1 activity 11 6.87e-01 8.14e-01 0.15300 0.039800 -0.148000 8.19e-01 3.95e-01
Transcriptional Regulation by E2F6 34 2.85e-01 4.80e-01 0.15300 -0.044300 -0.147000 6.55e-01 1.39e-01
Regulation of insulin secretion 62 1.19e-01 2.87e-01 0.15300 0.025600 -0.151000 7.27e-01 4.00e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 2.20e-01 4.08e-01 0.15300 -0.054500 -0.143000 5.46e-01 1.14e-01
Diseases of DNA Double-Strand Break Repair 41 2.20e-01 4.08e-01 0.15300 -0.054500 -0.143000 5.46e-01 1.14e-01
RNA Polymerase I Transcription Termination 30 3.28e-01 5.21e-01 0.15300 0.063600 0.139000 5.46e-01 1.89e-01
mTORC1-mediated signalling 24 4.61e-01 6.37e-01 0.15200 0.102000 -0.113000 3.85e-01 3.39e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 8.24e-01 8.97e-01 0.15200 -0.132000 0.074300 5.75e-01 7.52e-01
MHC class II antigen presentation 113 2.44e-02 9.66e-02 0.15100 0.045000 -0.145000 4.09e-01 7.93e-03
Signaling by Interleukins 386 3.33e-06 6.39e-05 0.15100 0.036000 -0.147000 2.25e-01 7.22e-07
RHOB GTPase cycle 64 1.32e-01 3.01e-01 0.15100 0.115000 -0.098200 1.12e-01 1.74e-01
Activation of PUMA and translocation to mitochondria 8 7.74e-01 8.68e-01 0.15100 -0.079100 0.129000 6.99e-01 5.28e-01
HDR through Single Strand Annealing (SSA) 37 2.54e-01 4.44e-01 0.15100 -0.095100 -0.117000 3.17e-01 2.18e-01
Signaling by FGFR2 61 1.37e-01 3.08e-01 0.15100 0.144000 -0.043900 5.16e-02 5.53e-01
Heparan sulfate/heparin (HS-GAG) metabolism 39 2.39e-01 4.26e-01 0.15000 0.090800 0.120000 3.27e-01 1.95e-01
Signaling by PDGF 48 2.21e-01 4.09e-01 0.15000 0.088800 -0.121000 2.87e-01 1.46e-01
HIV Transcription Initiation 45 2.06e-01 3.91e-01 0.15000 -0.028700 -0.148000 7.39e-01 8.67e-02
RNA Polymerase II HIV Promoter Escape 45 2.06e-01 3.91e-01 0.15000 -0.028700 -0.148000 7.39e-01 8.67e-02
RNA Polymerase II Promoter Escape 45 2.06e-01 3.91e-01 0.15000 -0.028700 -0.148000 7.39e-01 8.67e-02
RNA Polymerase II Transcription Initiation 45 2.06e-01 3.91e-01 0.15000 -0.028700 -0.148000 7.39e-01 8.67e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 2.06e-01 3.91e-01 0.15000 -0.028700 -0.148000 7.39e-01 8.67e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 2.06e-01 3.91e-01 0.15000 -0.028700 -0.148000 7.39e-01 8.67e-02
CaM pathway 27 3.76e-01 5.66e-01 0.15000 -0.131000 -0.073300 2.39e-01 5.10e-01
Calmodulin induced events 27 3.76e-01 5.66e-01 0.15000 -0.131000 -0.073300 2.39e-01 5.10e-01
Loss of Function of SMAD2/3 in Cancer 7 7.85e-01 8.75e-01 0.15000 -0.015400 -0.149000 9.44e-01 4.94e-01
Insulin receptor signalling cascade 40 2.71e-01 4.67e-01 0.15000 0.146000 -0.034200 1.10e-01 7.08e-01
Signaling by Leptin 10 7.31e-01 8.41e-01 0.15000 0.076100 -0.129000 6.77e-01 4.81e-01
IRF3-mediated induction of type I IFN 12 6.54e-01 7.90e-01 0.14900 0.052200 0.140000 7.54e-01 4.01e-01
SHC-mediated cascade:FGFR4 11 6.93e-01 8.14e-01 0.14900 0.007030 -0.149000 9.68e-01 3.92e-01
Mitotic Prophase 96 5.02e-02 1.61e-01 0.14900 0.074600 -0.129000 2.06e-01 2.86e-02
DNA Damage Reversal 8 7.75e-01 8.68e-01 0.14900 -0.050200 0.140000 8.06e-01 4.91e-01
Mitochondrial translation elongation 90 3.96e-02 1.36e-01 0.14900 0.098700 0.111000 1.06e-01 6.82e-02
Diseases of signal transduction by growth factor receptors and second messengers 399 2.93e-06 5.79e-05 0.14800 0.021200 -0.147000 4.67e-01 4.71e-07
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.58e-01 4.49e-01 0.14800 -0.125000 -0.079800 1.82e-01 3.95e-01
DAG and IP3 signaling 33 3.18e-01 5.11e-01 0.14800 -0.140000 -0.049800 1.65e-01 6.20e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 5.20e-01 6.86e-01 0.14800 0.136000 -0.058700 2.81e-01 6.41e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 6.72e-01 8.04e-01 0.14800 -0.119000 0.088300 4.58e-01 5.82e-01
Integration of energy metabolism 87 6.71e-02 1.91e-01 0.14800 0.056000 -0.137000 3.67e-01 2.73e-02
Diseases of mitotic cell cycle 38 2.68e-01 4.63e-01 0.14800 -0.050700 -0.139000 5.89e-01 1.38e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 2.19e-01 4.08e-01 0.14800 0.121000 -0.085000 1.40e-01 2.98e-01
Toll-like Receptor Cascades 162 4.08e-03 2.44e-02 0.14800 -0.038400 -0.143000 3.99e-01 1.75e-03
Signaling by NOTCH3 42 2.75e-01 4.69e-01 0.14700 0.134000 -0.062300 1.34e-01 4.85e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 2.79e-02 1.07e-01 0.14700 0.063600 -0.133000 2.35e-01 1.30e-02
Defective B4GALT7 causes EDS, progeroid type 10 7.38e-01 8.46e-01 0.14700 -0.078000 0.125000 6.69e-01 4.93e-01
Loss of Nlp from mitotic centrosomes 69 9.83e-02 2.50e-01 0.14700 -0.027800 -0.145000 6.89e-01 3.77e-02
Loss of proteins required for interphase microtubule organization from the centrosome 69 9.83e-02 2.50e-01 0.14700 -0.027800 -0.145000 6.89e-01 3.77e-02
Alpha-oxidation of phytanate 6 8.33e-01 9.00e-01 0.14700 -0.127000 0.074300 5.90e-01 7.53e-01
Homologous DNA Pairing and Strand Exchange 43 2.29e-01 4.17e-01 0.14700 -0.053300 -0.137000 5.45e-01 1.20e-01
Cell-Cell communication 107 2.55e-02 1.00e-01 0.14700 -0.057900 -0.135000 3.01e-01 1.58e-02
Dopamine Neurotransmitter Release Cycle 20 5.50e-01 7.10e-01 0.14600 -0.119000 0.084900 3.55e-01 5.11e-01
Activation of ATR in response to replication stress 37 2.94e-01 4.89e-01 0.14600 -0.022100 -0.145000 8.16e-01 1.28e-01
DNA Damage Bypass 47 1.96e-01 3.83e-01 0.14600 -0.088900 -0.116000 2.92e-01 1.68e-01
ERKs are inactivated 13 6.36e-01 7.74e-01 0.14600 0.100000 0.107000 5.32e-01 5.06e-01
Infectious disease 950 1.65e-12 7.57e-11 0.14500 0.064400 -0.130000 7.82e-04 1.03e-11
RHOD GTPase cycle 49 2.36e-01 4.23e-01 0.14500 0.079500 -0.122000 3.36e-01 1.41e-01
Metabolism of amine-derived hormones 10 7.40e-01 8.47e-01 0.14500 -0.048800 0.137000 7.89e-01 4.54e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 3.13e-04 2.99e-03 0.14500 0.060300 -0.132000 8.53e-02 1.73e-04
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 8.52e-01 9.13e-01 0.14500 -0.144000 -0.009660 5.76e-01 9.70e-01
Interleukin-4 and Interleukin-13 signaling 89 6.98e-02 1.97e-01 0.14400 0.039500 -0.139000 5.20e-01 2.38e-02
Synthesis of bile acids and bile salts 25 4.40e-01 6.19e-01 0.14400 -0.045600 -0.137000 6.93e-01 2.37e-01
FGFR2 alternative splicing 25 4.32e-01 6.11e-01 0.14400 0.115000 0.086200 3.19e-01 4.56e-01
Bacterial Infection Pathways 65 1.53e-01 3.32e-01 0.14400 0.075900 -0.122000 2.90e-01 8.89e-02
Nucleotide catabolism 28 4.46e-01 6.22e-01 0.14400 0.075800 -0.122000 4.87e-01 2.64e-01
SUMOylation of DNA replication proteins 46 2.61e-01 4.53e-01 0.14300 -0.132000 0.056200 1.22e-01 5.10e-01
Ubiquinol biosynthesis 13 6.57e-01 7.93e-01 0.14300 0.038100 0.138000 8.12e-01 3.88e-01
PI Metabolism 79 7.30e-02 2.04e-01 0.14300 -0.081000 -0.118000 2.13e-01 6.97e-02
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 6.64e-01 7.98e-01 0.14300 -0.134000 0.051200 3.87e-01 7.40e-01
Synthesis of pyrophosphates in the cytosol 8 7.71e-01 8.66e-01 0.14300 -0.132000 -0.054800 5.18e-01 7.88e-01
TRAF6 mediated NF-kB activation 23 5.22e-01 6.87e-01 0.14300 -0.113000 0.087100 3.49e-01 4.69e-01
FGFR2c ligand binding and activation 5 8.52e-01 9.13e-01 0.14200 -0.046400 -0.135000 8.57e-01 6.02e-01
Cytoprotection by HMOX1 53 2.20e-01 4.09e-01 0.14200 0.128000 -0.061400 1.06e-01 4.40e-01
HATs acetylate histones 92 5.88e-02 1.78e-01 0.14200 0.141000 0.016800 1.96e-02 7.81e-01
MAP kinase activation 63 1.70e-01 3.52e-01 0.14200 0.121000 -0.074600 9.78e-02 3.06e-01
Protein hydroxylation 17 5.74e-01 7.28e-01 0.14200 0.112000 0.087000 4.25e-01 5.34e-01
Chondroitin sulfate biosynthesis 12 6.93e-01 8.14e-01 0.14100 0.141000 0.010200 3.98e-01 9.51e-01
SLC15A4:TASL-dependent IRF5 activation 6 8.35e-01 9.01e-01 0.14100 0.141000 -0.000126 5.50e-01 1.00e+00
Mitochondrial translation termination 90 5.50e-02 1.69e-01 0.14100 0.098800 0.100000 1.05e-01 9.97e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 4.11e-01 5.96e-01 0.14100 -0.061000 -0.127000 5.76e-01 2.45e-01
Oncogene Induced Senescence 33 3.87e-01 5.76e-01 0.14100 0.032900 -0.137000 7.44e-01 1.74e-01
FLT3 Signaling 38 3.24e-01 5.17e-01 0.14100 0.004720 -0.141000 9.60e-01 1.34e-01
MITF-M-dependent gene expression 81 9.35e-02 2.42e-01 0.14000 0.008330 -0.140000 8.97e-01 2.95e-02
Eicosanoid ligand-binding receptors 13 6.89e-01 8.14e-01 0.14000 0.025200 -0.137000 8.75e-01 3.91e-01
Protein methylation 15 6.22e-01 7.63e-01 0.14000 0.098600 0.098600 5.08e-01 5.08e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 4.21e-01 6.01e-01 0.13900 0.138000 0.018100 1.98e-01 8.66e-01
Keratan sulfate/keratin metabolism 27 4.82e-01 6.55e-01 0.13900 0.075300 -0.117000 4.98e-01 2.93e-01
SUMOylation of DNA damage response and repair proteins 77 1.10e-01 2.71e-01 0.13900 -0.138000 0.010700 3.57e-02 8.71e-01
Lysine catabolism 10 7.40e-01 8.47e-01 0.13900 -0.032500 -0.135000 8.59e-01 4.60e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 5.69e-01 7.23e-01 0.13900 -0.136000 0.025000 2.91e-01 8.46e-01
Nicotinamide salvaging 15 6.66e-01 7.98e-01 0.13800 0.126000 -0.057800 3.99e-01 6.99e-01
Cytokine Signaling in Immune system 660 6.68e-09 1.97e-07 0.13800 -0.017900 -0.137000 4.32e-01 1.94e-09
Signaling by FGFR1 42 3.27e-01 5.21e-01 0.13800 0.114000 -0.077700 2.00e-01 3.84e-01
CaMK IV-mediated phosphorylation of CREB 8 7.84e-01 8.74e-01 0.13800 -0.126000 -0.056200 5.37e-01 7.83e-01
Chromosome Maintenance 102 6.80e-02 1.93e-01 0.13800 0.086600 -0.107000 1.31e-01 6.09e-02
Purine ribonucleoside monophosphate biosynthesis 9 7.88e-01 8.76e-01 0.13800 -0.082700 0.110000 6.68e-01 5.67e-01
Mitochondrial translation 96 5.23e-02 1.65e-01 0.13800 0.092800 0.102000 1.16e-01 8.52e-02
PERK regulates gene expression 30 4.27e-01 6.05e-01 0.13700 0.137000 -0.002970 1.93e-01 9.78e-01
Postmitotic nuclear pore complex (NPC) reformation 27 4.86e-01 6.58e-01 0.13700 -0.054300 0.126000 6.25e-01 2.57e-01
Nuclear Pore Complex (NPC) Disassembly 36 3.82e-01 5.71e-01 0.13600 -0.130000 0.039900 1.76e-01 6.78e-01
Diseases associated with the TLR signaling cascade 29 4.20e-01 6.01e-01 0.13600 -0.116000 -0.071100 2.80e-01 5.07e-01
Diseases of Immune System 29 4.20e-01 6.01e-01 0.13600 -0.116000 -0.071100 2.80e-01 5.07e-01
Activation of Matrix Metalloproteinases 20 5.64e-01 7.19e-01 0.13600 0.133000 0.025900 3.02e-01 8.41e-01
Negative regulators of DDX58/IFIH1 signaling 34 3.77e-01 5.66e-01 0.13500 -0.035300 -0.131000 7.22e-01 1.87e-01
RORA activates gene expression 18 5.86e-01 7.38e-01 0.13500 -0.097100 -0.093900 4.76e-01 4.90e-01
Neddylation 215 4.02e-03 2.43e-02 0.13500 0.053800 -0.124000 1.74e-01 1.75e-03
Transcriptional regulation by RUNX3 80 1.33e-01 3.04e-01 0.13500 0.104000 -0.085800 1.08e-01 1.85e-01
Reproduction 84 1.13e-01 2.76e-01 0.13500 0.043600 -0.127000 4.90e-01 4.36e-02
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 1.66e-01 3.46e-01 0.13500 -0.086200 -0.103000 2.45e-01 1.62e-01
TRP channels 21 5.60e-01 7.17e-01 0.13500 -0.134000 -0.010600 2.87e-01 9.33e-01
Regulation of gene expression in beta cells 7 8.15e-01 8.93e-01 0.13400 -0.114000 -0.071600 6.03e-01 7.43e-01
Axon guidance 454 1.27e-05 2.18e-04 0.13400 0.118000 -0.063800 1.62e-05 1.99e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.73e-01 6.48e-01 0.13400 0.088200 -0.101000 4.03e-01 3.38e-01
Hyaluronan uptake and degradation 12 7.07e-01 8.25e-01 0.13400 0.116000 0.066000 4.85e-01 6.92e-01
Signaling by ERBB2 TMD/JMD mutants 17 6.30e-01 7.71e-01 0.13400 -0.133000 -0.008200 3.41e-01 9.53e-01
Cargo recognition for clathrin-mediated endocytosis 88 1.09e-01 2.69e-01 0.13400 0.122000 -0.054800 4.83e-02 3.74e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 8.18e-01 8.94e-01 0.13300 0.119000 -0.059500 5.58e-01 7.71e-01
Anchoring of the basal body to the plasma membrane 97 6.20e-02 1.83e-01 0.13300 -0.071200 -0.113000 2.26e-01 5.49e-02
SRP-dependent cotranslational protein targeting to membrane 111 4.07e-02 1.38e-01 0.13300 0.097800 0.090600 7.50e-02 9.90e-02
Diseases of DNA repair 50 2.40e-01 4.26e-01 0.13300 -0.065900 -0.116000 4.20e-01 1.56e-01
Opioid Signalling 74 1.41e-01 3.14e-01 0.13300 0.006450 -0.133000 9.24e-01 4.78e-02
Adipogenesis 95 6.68e-02 1.91e-01 0.13300 -0.116000 -0.064900 5.00e-02 2.75e-01
G alpha (s) signalling events 93 7.44e-02 2.07e-01 0.13300 -0.042600 -0.126000 4.78e-01 3.55e-02
Lysosphingolipid and LPA receptors 11 7.40e-01 8.47e-01 0.13300 -0.131000 -0.021200 4.50e-01 9.03e-01
Mitochondrial translation initiation 90 7.54e-02 2.09e-01 0.13300 0.099700 0.088000 1.02e-01 1.49e-01
ISG15 antiviral mechanism 72 1.37e-01 3.08e-01 0.13300 -0.035500 -0.128000 6.03e-01 6.04e-02
Collagen chain trimerization 26 4.79e-01 6.53e-01 0.13300 -0.063900 -0.116000 5.73e-01 3.05e-01
Biosynthesis of DHA-derived SPMs 13 7.24e-01 8.37e-01 0.13300 -0.119000 0.058400 4.58e-01 7.16e-01
Extra-nuclear estrogen signaling 65 2.06e-01 3.91e-01 0.13200 0.088800 -0.098200 2.15e-01 1.71e-01
RNA Polymerase II Pre-transcription Events 77 1.28e-01 2.96e-01 0.13200 -0.011500 -0.132000 8.62e-01 4.56e-02
Neurotransmitter receptors and postsynaptic signal transmission 132 4.13e-02 1.39e-01 0.13200 0.080900 -0.104000 1.09e-01 3.83e-02
SUMO E3 ligases SUMOylate target proteins 161 1.37e-02 6.09e-02 0.13200 -0.131000 -0.017700 4.19e-03 6.98e-01
Defective B3GAT3 causes JDSSDHD 10 7.86e-01 8.75e-01 0.13200 -0.083500 0.102000 6.48e-01 5.77e-01
Signaling by BRAF and RAF1 fusions 59 2.44e-01 4.30e-01 0.13100 0.096900 -0.088800 1.98e-01 2.38e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 3.97e-01 5.86e-01 0.13100 -0.131000 0.005440 1.74e-01 9.55e-01
SARS-CoV Infections 427 3.58e-05 5.26e-04 0.13100 0.047300 -0.122000 9.41e-02 1.53e-05
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 5.91e-01 7.42e-01 0.13100 0.074000 0.108000 5.77e-01 4.16e-01
RAC2 GTPase cycle 85 1.12e-01 2.74e-01 0.13100 -0.002910 -0.131000 9.63e-01 3.74e-02
SUMOylation 167 1.21e-02 5.50e-02 0.13100 -0.127000 -0.029200 4.55e-03 5.16e-01
Viral Infection Pathways 769 1.85e-08 5.30e-07 0.13000 0.056600 -0.117000 7.64e-03 3.13e-08
Phase 0 - rapid depolarisation 22 5.57e-01 7.15e-01 0.13000 -0.034800 -0.125000 7.77e-01 3.08e-01
SHC1 events in ERBB4 signaling 10 7.80e-01 8.72e-01 0.13000 -0.128000 0.023400 4.83e-01 8.98e-01
Phenylalanine and tyrosine metabolism 9 8.03e-01 8.84e-01 0.13000 -0.126000 0.031800 5.14e-01 8.69e-01
Mitochondrial tRNA aminoacylation 21 6.09e-01 7.55e-01 0.12900 -0.114000 0.061000 3.65e-01 6.28e-01
Heme signaling 45 3.12e-01 5.06e-01 0.12800 -0.123000 -0.036800 1.54e-01 6.69e-01
MECP2 regulates transcription factors 5 8.75e-01 9.29e-01 0.12800 -0.107000 -0.070200 6.78e-01 7.86e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 7.07e-01 8.25e-01 0.12800 0.081500 0.098900 6.11e-01 5.37e-01
Toll Like Receptor 4 (TLR4) Cascade 138 3.17e-02 1.17e-01 0.12800 -0.014800 -0.127000 7.64e-01 9.95e-03
PI3K events in ERBB2 signaling 11 7.50e-01 8.55e-01 0.12800 0.053800 0.116000 7.57e-01 5.05e-01
Regulation of TP53 Expression and Degradation 36 4.37e-01 6.16e-01 0.12700 0.117000 -0.050400 2.25e-01 6.00e-01
Activation of the pre-replicative complex 32 4.52e-01 6.28e-01 0.12700 -0.013800 -0.127000 8.93e-01 2.15e-01
Regulation of innate immune responses to cytosolic DNA 14 7.29e-01 8.40e-01 0.12700 -0.071800 0.105000 6.42e-01 4.96e-01
Zinc transporters 12 7.64e-01 8.63e-01 0.12700 0.073700 -0.103000 6.58e-01 5.35e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 7.83e-01 8.73e-01 0.12700 -0.090700 0.088500 6.03e-01 6.11e-01
Metabolism of water-soluble vitamins and cofactors 114 5.36e-02 1.67e-01 0.12600 -0.109000 -0.063300 4.36e-02 2.43e-01
RHOA GTPase cycle 138 4.49e-02 1.47e-01 0.12600 0.052600 -0.115000 2.86e-01 1.99e-02
Purine catabolism 16 6.74e-01 8.04e-01 0.12600 0.122000 0.031300 4.00e-01 8.28e-01
RHO GTPase cycle 408 9.01e-05 1.06e-03 0.12500 0.008920 -0.125000 7.57e-01 1.59e-05
CTLA4 inhibitory signaling 21 6.11e-01 7.57e-01 0.12400 -0.002380 -0.124000 9.85e-01 3.24e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 3.49e-01 5.44e-01 0.12400 0.077800 -0.097100 3.46e-01 2.39e-01
RND1 GTPase cycle 36 4.54e-01 6.31e-01 0.12400 0.051900 -0.113000 5.90e-01 2.40e-01
RHOBTB3 ATPase cycle 10 7.88e-01 8.76e-01 0.12400 0.123000 0.019100 5.02e-01 9.17e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 6.89e-01 8.14e-01 0.12400 -0.124000 -0.001260 3.90e-01 9.93e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 5.38e-01 6.99e-01 0.12400 0.059300 0.109000 6.08e-01 3.45e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 7.69e-01 8.66e-01 0.12300 -0.119000 -0.031100 4.93e-01 8.58e-01
PTEN Regulation 126 5.31e-02 1.67e-01 0.12300 -0.017400 -0.122000 7.35e-01 1.80e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 4.21e-01 6.01e-01 0.12300 -0.042400 -0.116000 6.60e-01 2.30e-01
MET activates PTK2 signaling 21 6.42e-01 7.80e-01 0.12300 0.095400 -0.077800 4.49e-01 5.37e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 4.57e-01 6.32e-01 0.12300 -0.006590 -0.123000 9.47e-01 2.15e-01
Interleukin-17 signaling 68 2.38e-01 4.24e-01 0.12300 0.104000 -0.065800 1.39e-01 3.48e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.69e-01 5.60e-01 0.12300 0.039500 -0.116000 6.43e-01 1.72e-01
Signaling by Activin 13 7.50e-01 8.55e-01 0.12200 0.016300 -0.121000 9.19e-01 4.49e-01
Nervous system development 472 6.32e-05 7.88e-04 0.12200 0.104000 -0.064500 1.11e-04 1.65e-02
Positive epigenetic regulation of rRNA expression 60 2.44e-01 4.30e-01 0.12200 0.116000 0.037800 1.20e-01 6.12e-01
Retrograde neurotrophin signalling 12 7.71e-01 8.66e-01 0.12200 0.119000 -0.024100 4.74e-01 8.85e-01
Cellular Senescence 142 5.11e-02 1.63e-01 0.12200 0.048300 -0.112000 3.21e-01 2.14e-02
Transcriptional regulation of white adipocyte differentiation 77 1.57e-01 3.35e-01 0.12200 -0.081200 -0.090600 2.18e-01 1.69e-01
HIV Infection 213 1.10e-02 5.16e-02 0.12200 0.032000 -0.117000 4.21e-01 3.18e-03
Inositol phosphate metabolism 42 3.65e-01 5.57e-01 0.12200 -0.095500 -0.075100 2.84e-01 3.99e-01
Nucleotide salvage 21 6.19e-01 7.62e-01 0.12100 -0.021500 -0.119000 8.64e-01 3.44e-01
Phosphorylation of the APC/C 20 6.64e-01 7.98e-01 0.12100 0.063800 -0.103000 6.21e-01 4.27e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 6.67e-01 7.99e-01 0.12100 -0.017200 -0.120000 9.00e-01 3.80e-01
RNA Polymerase III Abortive And Retractive Initiation 40 3.91e-01 5.79e-01 0.12100 0.060700 0.104000 5.07e-01 2.53e-01
RNA Polymerase III Transcription 40 3.91e-01 5.79e-01 0.12100 0.060700 0.104000 5.07e-01 2.53e-01
Signaling by EGFR in Cancer 22 6.16e-01 7.60e-01 0.12100 -0.002560 -0.121000 9.83e-01 3.27e-01
Signaling by Nuclear Receptors 210 9.34e-03 4.48e-02 0.12100 -0.018600 -0.119000 6.42e-01 2.93e-03
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.28e-01 6.91e-01 0.12100 0.111000 -0.047900 2.87e-01 6.45e-01
Organelle biogenesis and maintenance 277 1.58e-03 1.13e-02 0.12000 -0.073800 -0.095200 3.46e-02 6.42e-03
NoRC negatively regulates rRNA expression 60 2.93e-01 4.88e-01 0.12000 0.109000 -0.050600 1.44e-01 4.98e-01
Translation 293 1.13e-03 8.36e-03 0.12000 0.083500 0.086200 1.39e-02 1.12e-02
Integrin cell surface interactions 64 2.59e-01 4.50e-01 0.12000 0.018100 -0.119000 8.03e-01 1.01e-01
Diseases associated with glycosylation precursor biosynthesis 15 7.13e-01 8.29e-01 0.12000 0.116000 0.031400 4.38e-01 8.33e-01
Transport of Mature Transcript to Cytoplasm 81 1.86e-01 3.70e-01 0.12000 -0.028500 0.116000 6.57e-01 7.02e-02
Activated point mutants of FGFR2 7 8.51e-01 9.13e-01 0.11900 -0.105000 -0.056900 6.31e-01 7.94e-01
Lysosome Vesicle Biogenesis 32 5.29e-01 6.91e-01 0.11900 0.104000 -0.058600 3.10e-01 5.66e-01
Transport and synthesis of PAPS 6 8.81e-01 9.30e-01 0.11900 0.008730 -0.119000 9.70e-01 6.15e-01
Dual Incision in GG-NER 41 4.37e-01 6.16e-01 0.11900 -0.112000 0.039200 2.14e-01 6.64e-01
Signaling by FGFR in disease 52 3.31e-01 5.25e-01 0.11900 -0.001430 -0.119000 9.86e-01 1.39e-01
Termination of translesion DNA synthesis 32 4.90e-01 6.60e-01 0.11900 -0.111000 -0.040500 2.75e-01 6.92e-01
RNA Polymerase III Transcription Initiation 36 4.41e-01 6.19e-01 0.11800 0.066900 0.097800 4.87e-01 3.10e-01
PI5P Regulates TP53 Acetylation 8 8.44e-01 9.08e-01 0.11800 0.010700 0.117000 9.58e-01 5.66e-01
Cell junction organization 76 1.86e-01 3.71e-01 0.11700 -0.103000 -0.057000 1.22e-01 3.90e-01
FGFR1b ligand binding and activation 5 8.96e-01 9.42e-01 0.11700 0.103000 0.055300 6.90e-01 8.30e-01
Class B/2 (Secretin family receptors) 52 3.19e-01 5.12e-01 0.11700 -0.063700 -0.097600 4.27e-01 2.23e-01
Molecules associated with elastic fibres 26 5.70e-01 7.24e-01 0.11700 -0.042900 -0.108000 7.05e-01 3.39e-01
Regulation of TP53 Degradation 35 5.17e-01 6.85e-01 0.11600 0.092200 -0.071200 3.45e-01 4.66e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 7.55e-01 8.59e-01 0.11600 0.105000 0.049300 5.11e-01 7.58e-01
IRAK2 mediated activation of TAK1 complex 10 8.19e-01 8.95e-01 0.11600 0.015800 -0.115000 9.31e-01 5.29e-01
Intrinsic Pathway for Apoptosis 53 3.65e-01 5.57e-01 0.11600 0.104000 -0.050600 1.89e-01 5.24e-01
Regulation of TP53 Activity through Phosphorylation 88 1.80e-01 3.64e-01 0.11600 0.026500 -0.113000 6.67e-01 6.72e-02
Post-translational protein modification 1231 1.99e-10 6.96e-09 0.11600 0.039400 -0.109000 2.02e-02 1.26e-10
Diseases associated with O-glycosylation of proteins 46 4.25e-01 6.04e-01 0.11600 -0.095800 0.064600 2.61e-01 4.49e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 8.23e-01 8.97e-01 0.11500 0.069500 0.092100 7.18e-01 6.32e-01
Telomere Maintenance 78 2.40e-01 4.26e-01 0.11500 0.079500 -0.083100 2.25e-01 2.04e-01
Disease 1605 9.79e-13 4.59e-11 0.11400 0.042400 -0.106000 4.69e-03 1.43e-12
Phospholipase C-mediated cascade; FGFR3 5 9.05e-01 9.48e-01 0.11400 0.012400 0.113000 9.62e-01 6.61e-01
Glutamate and glutamine metabolism 12 7.98e-01 8.83e-01 0.11400 0.111000 -0.023900 5.06e-01 8.86e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 3.62e-01 5.56e-01 0.11300 -0.084600 0.075400 2.69e-01 3.25e-01
TRAIL signaling 8 8.55e-01 9.13e-01 0.11300 -0.006120 -0.113000 9.76e-01 5.80e-01
Sensory perception of taste 22 6.40e-01 7.79e-01 0.11300 0.037000 0.107000 7.64e-01 3.85e-01
TNFR1-induced NF-kappa-B signaling pathway 32 5.25e-01 6.89e-01 0.11300 -0.109000 -0.031200 2.87e-01 7.60e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 9.02e-01 9.47e-01 0.11300 0.094500 0.061900 7.14e-01 8.11e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 35 4.99e-01 6.67e-01 0.11300 0.109000 0.028900 2.65e-01 7.68e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.26e-01 8.38e-01 0.11300 0.012000 -0.112000 9.31e-01 4.24e-01
Deadenylation-dependent mRNA decay 50 3.81e-01 5.70e-01 0.11200 -0.011400 -0.112000 8.89e-01 1.71e-01
Diseases associated with glycosaminoglycan metabolism 24 6.31e-01 7.71e-01 0.11200 0.112000 0.008890 3.43e-01 9.40e-01
SLC transporter disorders 75 2.72e-01 4.67e-01 0.11200 -0.073300 0.084700 2.72e-01 2.05e-01
Collagen degradation 41 4.92e-01 6.62e-01 0.11100 0.063100 -0.091700 4.84e-01 3.10e-01
Beta-oxidation of very long chain fatty acids 11 8.25e-01 8.98e-01 0.11100 0.097700 -0.053400 5.75e-01 7.59e-01
Cellular responses to stimuli 775 2.54e-06 5.14e-05 0.11100 0.087500 -0.068800 3.44e-05 1.13e-03
TBC/RABGAPs 45 4.57e-01 6.32e-01 0.11100 0.051800 -0.098400 5.47e-01 2.54e-01
Mitochondrial protein degradation 96 1.61e-01 3.40e-01 0.11100 0.110000 0.018600 6.37e-02 7.53e-01
Metabolism of porphyrins 22 6.86e-01 8.13e-01 0.11100 -0.089400 0.065600 4.68e-01 5.94e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 7.32e-01 8.42e-01 0.11100 -0.004220 0.110000 9.76e-01 4.30e-01
Complex IV assembly 45 4.21e-01 6.01e-01 0.11000 0.104000 0.037200 2.29e-01 6.66e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 5.75e-01 7.29e-01 0.11000 0.081900 0.073700 4.53e-01 5.00e-01
Intra-Golgi traffic 43 4.83e-01 6.56e-01 0.11000 0.059000 -0.093000 5.03e-01 2.91e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 6.33e-01 7.73e-01 0.11000 0.091600 -0.061000 4.10e-01 5.83e-01
Centrosome maturation 81 2.06e-01 3.91e-01 0.11000 -0.058100 -0.093400 3.66e-01 1.46e-01
Recruitment of mitotic centrosome proteins and complexes 81 2.06e-01 3.91e-01 0.11000 -0.058100 -0.093400 3.66e-01 1.46e-01
Resolution of D-Loop Structures 35 5.29e-01 6.91e-01 0.11000 -0.001530 -0.110000 9.87e-01 2.61e-01
Generic Transcription Pathway 1067 2.35e-09 7.15e-08 0.11000 -0.070000 -0.084400 1.12e-04 3.23e-06
RAC3 GTPase cycle 86 2.29e-01 4.17e-01 0.11000 0.037500 -0.103000 5.48e-01 9.86e-02
Interconversion of nucleotide di- and triphosphates 27 6.32e-01 7.72e-01 0.10900 0.042300 -0.101000 7.04e-01 3.64e-01
Disorders of transmembrane transporters 134 1.05e-01 2.63e-01 0.10900 0.045400 -0.099300 3.64e-01 4.71e-02
Recognition of DNA damage by PCNA-containing replication complex 30 5.61e-01 7.18e-01 0.10900 -0.086800 -0.065900 4.11e-01 5.32e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 4.27e-01 6.05e-01 0.10800 -0.014600 -0.108000 8.63e-01 2.02e-01
Respiratory syncytial virus (RSV) attachment and entry 17 7.58e-01 8.60e-01 0.10800 0.073500 -0.079700 6.00e-01 5.69e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 6.58e-01 7.93e-01 0.10800 0.063900 0.087500 6.04e-01 4.78e-01
RNA Polymerase II Transcription 1185 5.94e-10 1.93e-08 0.10800 -0.063800 -0.087200 2.17e-04 4.35e-07
Signal Transduction 2026 4.54e-14 2.72e-12 0.10800 0.034100 -0.102000 1.16e-02 2.99e-14
EGR2 and SOX10-mediated initiation of Schwann cell myelination 21 6.83e-01 8.11e-01 0.10800 -0.104000 -0.027300 4.09e-01 8.28e-01
DNA Double Strand Break Response 47 4.62e-01 6.38e-01 0.10800 0.043900 -0.098300 6.03e-01 2.44e-01
Diseases associated with N-glycosylation of proteins 20 6.87e-01 8.14e-01 0.10700 0.078600 0.073100 5.43e-01 5.71e-01
Negative epigenetic regulation of rRNA expression 63 3.55e-01 5.50e-01 0.10700 0.101000 -0.036200 1.66e-01 6.20e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 9 8.65e-01 9.21e-01 0.10700 0.054900 -0.092000 7.75e-01 6.33e-01
Defective EXT2 causes exostoses 2 9 8.65e-01 9.21e-01 0.10700 0.054900 -0.092000 7.75e-01 6.33e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 6.53e-01 7.90e-01 0.10700 -0.056600 -0.090800 6.38e-01 4.51e-01
Translesion synthesis by POLK 17 7.34e-01 8.43e-01 0.10600 -0.090400 -0.055700 5.19e-01 6.91e-01
MITF-M-regulated melanocyte development 110 1.78e-01 3.63e-01 0.10500 0.042900 -0.096300 4.36e-01 8.11e-02
Recruitment of NuMA to mitotic centrosomes 88 2.30e-01 4.18e-01 0.10500 -0.001550 -0.105000 9.80e-01 8.78e-02
Regulation of FZD by ubiquitination 15 7.94e-01 8.79e-01 0.10500 0.076500 -0.072300 6.08e-01 6.28e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 10 8.36e-01 9.01e-01 0.10500 0.084700 0.062400 6.43e-01 7.33e-01
Formation of WDR5-containing histone-modifying complexes 42 5.19e-01 6.86e-01 0.10500 -0.095500 0.043900 2.84e-01 6.23e-01
Translesion synthesis by REV1 16 7.61e-01 8.62e-01 0.10500 -0.103000 -0.019500 4.75e-01 8.93e-01
Transport of vitamins, nucleosides, and related molecules 31 5.87e-01 7.39e-01 0.10500 0.025500 0.102000 8.06e-01 3.27e-01
Host Interactions of HIV factors 118 1.56e-01 3.35e-01 0.10500 0.029100 -0.101000 5.86e-01 5.92e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.71e-01 8.02e-01 0.10400 0.042700 0.095100 7.23e-01 4.30e-01
Nef Mediated CD4 Down-regulation 9 8.54e-01 9.13e-01 0.10400 0.086000 0.058700 6.55e-01 7.61e-01
Methylation 13 8.01e-01 8.83e-01 0.10400 0.098500 0.033100 5.38e-01 8.36e-01
Hydrolysis of LPC 8 8.73e-01 9.27e-01 0.10400 0.098900 0.031800 6.28e-01 8.76e-01
Activation of HOX genes during differentiation 68 3.63e-01 5.57e-01 0.10300 0.084100 -0.060300 2.31e-01 3.90e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 3.63e-01 5.57e-01 0.10300 0.084100 -0.060300 2.31e-01 3.90e-01
Toll Like Receptor 2 (TLR2) Cascade 109 1.84e-01 3.68e-01 0.10300 0.016900 -0.102000 7.61e-01 6.67e-02
Toll Like Receptor TLR1:TLR2 Cascade 109 1.84e-01 3.68e-01 0.10300 0.016900 -0.102000 7.61e-01 6.67e-02
G alpha (q) signalling events 138 1.33e-01 3.03e-01 0.10300 0.062400 -0.081700 2.06e-01 9.75e-02
HCMV Late Events 67 3.50e-01 5.45e-01 0.10300 0.102000 -0.007480 1.47e-01 9.16e-01
Uptake and actions of bacterial toxins 27 6.29e-01 7.71e-01 0.10300 -0.068000 -0.076900 5.41e-01 4.89e-01
Regulation of endogenous retroelements 92 2.13e-01 4.00e-01 0.10300 -0.045600 -0.091900 4.50e-01 1.28e-01
Defective GALNT12 causes CRCS1 8 8.78e-01 9.29e-01 0.10200 -0.020600 -0.100000 9.20e-01 6.23e-01
Glycosphingolipid metabolism 46 4.96e-01 6.66e-01 0.10200 0.100000 -0.020300 2.40e-01 8.12e-01
Signaling by Receptor Tyrosine Kinases 441 1.92e-03 1.32e-02 0.10200 0.063900 -0.079600 2.15e-02 4.19e-03
Drug ADME 55 3.95e-01 5.84e-01 0.10200 -0.073400 -0.070800 3.47e-01 3.64e-01
Fanconi Anemia Pathway 36 5.68e-01 7.23e-01 0.10200 -0.102000 -0.004390 2.91e-01 9.64e-01
CRMPs in Sema3A signaling 13 8.26e-01 8.98e-01 0.10100 0.032800 -0.095900 8.38e-01 5.49e-01
Mitochondrial iron-sulfur cluster biogenesis 13 8.29e-01 8.99e-01 0.10000 -0.095000 0.032700 5.53e-01 8.38e-01
LDL clearance 18 7.45e-01 8.52e-01 0.10000 0.072400 0.069300 5.95e-01 6.11e-01
Release of apoptotic factors from the mitochondria 6 9.07e-01 9.49e-01 0.10000 -0.065900 -0.075200 7.80e-01 7.50e-01
TNF signaling 56 4.03e-01 5.92e-01 0.09990 -0.063800 -0.076900 4.09e-01 3.20e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 8.93e-01 9.40e-01 0.09950 0.034000 -0.093500 8.68e-01 6.47e-01
DNA Double-Strand Break Repair 137 1.16e-01 2.82e-01 0.09950 -0.038000 -0.092000 4.42e-01 6.31e-02
Metabolism of proteins 1758 2.27e-10 7.79e-09 0.09940 0.060100 -0.079100 2.89e-05 3.69e-08
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 6.90e-01 8.14e-01 0.09930 0.000936 -0.099300 9.94e-01 3.90e-01
Degradation of the extracellular matrix 92 2.87e-01 4.82e-01 0.09910 0.067200 -0.072900 2.66e-01 2.27e-01
G alpha (12/13) signalling events 68 3.64e-01 5.57e-01 0.09890 -0.005550 -0.098700 9.37e-01 1.59e-01
Peroxisomal protein import 58 4.01e-01 5.89e-01 0.09870 -0.055700 -0.081500 4.63e-01 2.83e-01
Iron uptake and transport 52 4.89e-01 6.60e-01 0.09820 0.092200 -0.033700 2.50e-01 6.74e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.31e-01 4.19e-01 0.09810 0.016400 -0.096700 7.73e-01 8.83e-02
RAF-independent MAPK1/3 activation 21 7.25e-01 8.37e-01 0.09800 0.039100 0.089800 7.56e-01 4.76e-01
Post NMDA receptor activation events 60 4.46e-01 6.22e-01 0.09780 0.044000 -0.087300 5.55e-01 2.42e-01
Gene expression (Transcription) 1391 1.68e-09 5.28e-08 0.09780 -0.059200 -0.077800 2.18e-04 1.19e-06
EPH-ephrin mediated repulsion of cells 42 5.32e-01 6.93e-01 0.09710 -0.039700 -0.088600 6.56e-01 3.21e-01
Peroxisomal lipid metabolism 27 6.61e-01 7.96e-01 0.09710 -0.073000 -0.064000 5.11e-01 5.65e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 9.21e-01 9.56e-01 0.09690 0.017600 -0.095300 9.41e-01 6.86e-01
TGFBR1 KD Mutants in Cancer 6 9.21e-01 9.56e-01 0.09690 0.017600 -0.095300 9.41e-01 6.86e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 2.33e-01 4.19e-01 0.09680 0.025300 -0.093400 6.49e-01 9.35e-02
Toll Like Receptor TLR6:TLR2 Cascade 108 2.33e-01 4.19e-01 0.09680 0.025300 -0.093400 6.49e-01 9.35e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 11 8.55e-01 9.13e-01 0.09680 -0.003100 -0.096700 9.86e-01 5.79e-01
Diseases of programmed cell death 58 4.55e-01 6.31e-01 0.09670 0.094300 -0.021300 2.14e-01 7.79e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 7.94e-01 8.79e-01 0.09640 -0.094300 0.020000 5.01e-01 8.86e-01
G-protein beta:gamma signalling 29 6.77e-01 8.07e-01 0.09630 0.023100 -0.093400 8.29e-01 3.84e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 10 8.79e-01 9.30e-01 0.09570 -0.043500 0.085200 8.12e-01 6.41e-01
Striated Muscle Contraction 25 7.23e-01 8.36e-01 0.09570 0.038300 -0.087700 7.41e-01 4.48e-01
Oncogenic MAPK signaling 75 3.86e-01 5.74e-01 0.09550 0.052600 -0.079700 4.31e-01 2.33e-01
G alpha (i) signalling events 193 9.05e-02 2.36e-01 0.09500 0.059400 -0.074200 1.55e-01 7.57e-02
Metabolism of lipids 631 2.40e-04 2.49e-03 0.09480 -0.001570 -0.094800 9.46e-01 4.83e-05
HCMV Infection 106 2.60e-01 4.52e-01 0.09450 0.088300 -0.033600 1.16e-01 5.50e-01
GRB2 events in ERBB2 signaling 11 8.60e-01 9.17e-01 0.09400 0.016900 0.092400 9.22e-01 5.96e-01
RNA Polymerase I Promoter Clearance 64 4.12e-01 5.97e-01 0.09390 0.090100 0.026500 2.12e-01 7.14e-01
RNA Polymerase I Transcription 64 4.12e-01 5.97e-01 0.09390 0.090100 0.026500 2.12e-01 7.14e-01
Negative regulation of MAPK pathway 42 5.99e-01 7.48e-01 0.09370 0.075000 -0.056200 4.00e-01 5.28e-01
Developmental Biology 904 2.60e-05 4.00e-04 0.09370 0.062300 -0.070000 1.51e-03 3.62e-04
Synthesis of IP3 and IP4 in the cytosol 22 7.61e-01 8.62e-01 0.09310 -0.032400 0.087300 7.93e-01 4.78e-01
Cellular responses to stress 694 2.99e-04 2.93e-03 0.09300 0.076300 -0.053300 6.18e-04 1.69e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 3.67e-01 5.58e-01 0.09290 0.064900 -0.066400 3.04e-01 2.93e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 4.46e-01 6.22e-01 0.09260 -0.092300 -0.006520 2.09e-01 9.29e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 4.07e-01 5.93e-01 0.09180 -0.052600 -0.075200 4.60e-01 2.91e-01
RET signaling 32 6.86e-01 8.13e-01 0.09140 0.040200 -0.082100 6.94e-01 4.22e-01
Phase II - Conjugation of compounds 68 4.56e-01 6.32e-01 0.09120 0.071700 -0.056300 3.06e-01 4.22e-01
Metal ion SLC transporters 19 8.00e-01 8.83e-01 0.09100 0.083400 -0.036500 5.29e-01 7.83e-01
Translesion synthesis by POLI 17 8.14e-01 8.93e-01 0.09070 -0.089600 0.014500 5.23e-01 9.18e-01
Toll Like Receptor 3 (TLR3) Cascade 104 2.77e-01 4.71e-01 0.09070 0.000196 -0.090700 9.97e-01 1.10e-01
HDR through Homologous Recombination (HRR) 68 4.07e-01 5.93e-01 0.09020 -0.059500 -0.067700 3.96e-01 3.34e-01
PTK6 promotes HIF1A stabilization 6 9.35e-01 9.63e-01 0.08950 0.073800 -0.050600 7.54e-01 8.30e-01
Plasma lipoprotein clearance 33 6.82e-01 8.10e-01 0.08930 -0.019700 0.087100 8.45e-01 3.87e-01
Signaling by NTRKs 116 2.76e-01 4.70e-01 0.08880 0.040300 -0.079200 4.53e-01 1.41e-01
Formation of RNA Pol II elongation complex 56 5.13e-01 6.81e-01 0.08860 -0.005090 -0.088400 9.47e-01 2.52e-01
RNA Polymerase II Transcription Elongation 56 5.13e-01 6.81e-01 0.08860 -0.005090 -0.088400 9.47e-01 2.52e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 7.14e-01 8.29e-01 0.08820 0.078400 0.040300 4.80e-01 7.17e-01
Association of TriC/CCT with target proteins during biosynthesis 35 6.85e-01 8.12e-01 0.08790 0.044200 -0.076000 6.51e-01 4.37e-01
Signaling by ERBB2 in Cancer 21 7.80e-01 8.72e-01 0.08740 -0.014400 -0.086200 9.09e-01 4.94e-01
Signaling by Non-Receptor Tyrosine Kinases 47 6.07e-01 7.53e-01 0.08740 0.071500 -0.050200 3.96e-01 5.51e-01
Signaling by PTK6 47 6.07e-01 7.53e-01 0.08740 0.071500 -0.050200 3.96e-01 5.51e-01
PI3K Cascade 31 6.93e-01 8.14e-01 0.08710 0.085300 0.017700 4.11e-01 8.65e-01
NRAGE signals death through JNK 52 5.42e-01 7.01e-01 0.08700 -0.085100 -0.018000 2.88e-01 8.22e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 8.34e-01 9.00e-01 0.08690 -0.077400 -0.039500 6.04e-01 7.91e-01
Lewis blood group biosynthesis 13 8.52e-01 9.13e-01 0.08680 0.061700 0.061100 7.00e-01 7.03e-01
FasL/ CD95L signaling 5 9.49e-01 9.73e-01 0.08650 0.072200 -0.047700 7.80e-01 8.54e-01
Signaling by ERBB4 45 6.15e-01 7.59e-01 0.08640 0.021500 -0.083700 8.03e-01 3.31e-01
Glyoxylate metabolism and glycine degradation 13 8.71e-01 9.26e-01 0.08620 0.081300 -0.028600 6.12e-01 8.58e-01
PIP3 activates AKT signaling 232 8.13e-02 2.19e-01 0.08620 0.013400 -0.085100 7.26e-01 2.55e-02
Sensory Perception 187 1.34e-01 3.04e-01 0.08610 0.084400 -0.016800 4.65e-02 6.93e-01
Cytosolic tRNA aminoacylation 24 7.69e-01 8.66e-01 0.08560 0.005460 -0.085400 9.63e-01 4.69e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 107 3.01e-01 4.95e-01 0.08540 -0.084600 -0.011900 1.31e-01 8.31e-01
Listeria monocytogenes entry into host cells 17 8.41e-01 9.05e-01 0.08510 0.039300 -0.075400 7.79e-01 5.90e-01
WNT ligand biogenesis and trafficking 19 8.00e-01 8.83e-01 0.08500 -0.064800 -0.054900 6.25e-01 6.78e-01
Fatty acid metabolism 152 1.70e-01 3.51e-01 0.08490 -0.056300 -0.063600 2.31e-01 1.76e-01
MyD88-independent TLR4 cascade 108 3.11e-01 5.06e-01 0.08480 -0.001090 -0.084800 9.84e-01 1.28e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 3.11e-01 5.06e-01 0.08480 -0.001090 -0.084800 9.84e-01 1.28e-01
STAT5 Activation 7 9.26e-01 9.58e-01 0.08450 -0.008620 -0.084100 9.69e-01 7.00e-01
SUMOylation of intracellular receptors 26 7.74e-01 8.68e-01 0.08390 -0.044300 0.071200 6.96e-01 5.30e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 78 4.20e-01 6.01e-01 0.08370 -0.031700 -0.077400 6.28e-01 2.37e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 8.19e-01 8.95e-01 0.08350 0.001330 -0.083500 9.92e-01 5.28e-01
Trafficking of AMPA receptors 19 8.19e-01 8.95e-01 0.08350 0.001330 -0.083500 9.92e-01 5.28e-01
Extracellular matrix organization 213 1.31e-01 2.99e-01 0.08340 0.062600 -0.055000 1.15e-01 1.66e-01
Transcriptional activation of mitochondrial biogenesis 52 5.57e-01 7.15e-01 0.08320 -0.056000 -0.061500 4.85e-01 4.43e-01
Metabolism of vitamins and cofactors 163 1.67e-01 3.48e-01 0.08300 -0.074400 -0.036800 1.01e-01 4.18e-01
Signaling by ERBB2 KD Mutants 20 8.01e-01 8.83e-01 0.08260 -0.061900 -0.054700 6.32e-01 6.72e-01
Negative regulation of the PI3K/AKT network 91 4.25e-01 6.04e-01 0.08240 0.063000 -0.053200 2.99e-01 3.80e-01
Respiratory electron transport 149 1.97e-01 3.85e-01 0.08220 0.067900 0.046400 1.53e-01 3.28e-01
Phase I - Functionalization of compounds 62 5.33e-01 6.93e-01 0.08220 -0.001200 0.082200 9.87e-01 2.63e-01
Aspirin ADME 13 8.80e-01 9.30e-01 0.08220 0.018600 -0.080100 9.08e-01 6.17e-01
RAC1 GTPase cycle 170 1.69e-01 3.51e-01 0.08190 -0.021200 -0.079100 6.33e-01 7.51e-02
Visual phototransduction 58 5.54e-01 7.14e-01 0.08160 0.081100 0.008250 2.85e-01 9.13e-01
Metabolism of steroid hormones 21 8.02e-01 8.84e-01 0.08130 0.076200 0.028500 5.46e-01 8.21e-01
Homology Directed Repair 110 3.31e-01 5.26e-01 0.08110 -0.008690 -0.080600 8.75e-01 1.44e-01
Death Receptor Signaling 145 2.15e-01 4.03e-01 0.08100 -0.052900 -0.061300 2.72e-01 2.03e-01
Reversal of alkylation damage by DNA dioxygenases 7 9.31e-01 9.61e-01 0.08080 0.017400 0.078900 9.37e-01 7.18e-01
SARS-CoV-2-host interactions 181 1.98e-01 3.86e-01 0.08060 -0.053900 0.059900 2.11e-01 1.64e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 4.90e-01 6.60e-01 0.08020 -0.078700 0.015100 2.35e-01 8.20e-01
Intracellular signaling by second messengers 264 7.91e-02 2.15e-01 0.08000 -0.003810 -0.079900 9.15e-01 2.55e-02
Aspartate and asparagine metabolism 8 9.32e-01 9.61e-01 0.07990 -0.059900 0.052800 7.69e-01 7.96e-01
GRB2 events in EGFR signaling 10 9.05e-01 9.48e-01 0.07970 -0.019500 -0.077300 9.15e-01 6.72e-01
MicroRNA (miRNA) biogenesis 24 7.81e-01 8.72e-01 0.07950 0.061900 0.049800 5.99e-01 6.73e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 36 7.12e-01 8.29e-01 0.07950 0.079400 -0.003770 4.10e-01 9.69e-01
Voltage gated Potassium channels 25 8.03e-01 8.84e-01 0.07950 -0.053900 0.058400 6.41e-01 6.13e-01
DNA Repair 288 5.42e-02 1.68e-01 0.07930 -0.058000 -0.054100 9.02e-02 1.14e-01
Transport of small molecules 548 9.04e-03 4.35e-02 0.07930 0.041100 -0.067800 1.00e-01 6.67e-03
STING mediated induction of host immune responses 15 8.77e-01 9.29e-01 0.07920 -0.052000 0.059700 7.27e-01 6.89e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 8.16e-01 8.94e-01 0.07900 0.062500 0.048400 6.29e-01 7.08e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.88e-01 6.60e-01 0.07830 -0.064700 0.044200 3.06e-01 4.84e-01
Signaling by NTRK1 (TRKA) 102 4.05e-01 5.93e-01 0.07830 0.018800 -0.076000 7.43e-01 1.85e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 7.89e-01 8.76e-01 0.07790 -0.052300 -0.057800 6.57e-01 6.24e-01
IRS-mediated signalling 35 7.38e-01 8.47e-01 0.07770 0.073800 -0.024400 4.50e-01 8.02e-01
SHC1 events in EGFR signaling 11 9.03e-01 9.47e-01 0.07760 -0.008790 -0.077100 9.60e-01 6.58e-01
Paracetamol ADME 19 8.53e-01 9.13e-01 0.07750 -0.058300 0.051100 6.60e-01 7.00e-01
Signaling by FGFR 73 5.37e-01 6.97e-01 0.07700 0.073900 -0.021600 2.75e-01 7.50e-01
Transmission across Chemical Synapses 179 2.33e-01 4.19e-01 0.07680 0.047800 -0.060100 2.70e-01 1.65e-01
Dual incision in TC-NER 63 5.57e-01 7.15e-01 0.07660 -0.072000 -0.026100 3.23e-01 7.21e-01
Diseases of branched-chain amino acid catabolism 13 8.95e-01 9.41e-01 0.07630 0.013200 -0.075200 9.34e-01 6.39e-01
Transcription of the HIV genome 67 5.75e-01 7.28e-01 0.07620 0.027500 -0.071000 6.97e-01 3.15e-01
SARS-CoV-1 Infection 137 3.16e-01 5.10e-01 0.07580 0.011700 -0.074900 8.13e-01 1.30e-01
DNA Damage Recognition in GG-NER 38 7.05e-01 8.24e-01 0.07570 0.034900 0.067200 7.09e-01 4.73e-01
Pausing and recovery of Tat-mediated HIV elongation 30 7.57e-01 8.60e-01 0.07570 0.041400 0.063400 6.95e-01 5.48e-01
Tat-mediated HIV elongation arrest and recovery 30 7.57e-01 8.60e-01 0.07570 0.041400 0.063400 6.95e-01 5.48e-01
FLT3 signaling by CBL mutants 7 9.39e-01 9.65e-01 0.07530 0.070000 0.027800 7.49e-01 8.99e-01
Signaling by NOTCH2 33 7.73e-01 8.68e-01 0.07470 -0.040900 0.062500 6.84e-01 5.34e-01
Endogenous sterols 17 8.78e-01 9.30e-01 0.07420 -0.055000 0.049800 6.95e-01 7.22e-01
IGF1R signaling cascade 37 7.48e-01 8.55e-01 0.07400 0.069800 -0.024500 4.62e-01 7.97e-01
Citric acid cycle (TCA cycle) 34 7.69e-01 8.66e-01 0.07390 0.031300 -0.066900 7.52e-01 4.99e-01
Processing of SMDT1 15 8.92e-01 9.40e-01 0.07380 -0.038100 0.063100 7.98e-01 6.72e-01
Processing of Intronless Pre-mRNAs 20 8.48e-01 9.11e-01 0.07360 0.073400 0.005380 5.70e-01 9.67e-01
Regulation of expression of SLITs and ROBOs 149 2.72e-01 4.67e-01 0.07350 0.056900 0.046400 2.30e-01 3.28e-01
Ovarian tumor domain proteases 37 7.55e-01 8.59e-01 0.07330 0.032700 -0.065700 7.31e-01 4.90e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 6.16e-01 7.60e-01 0.07300 0.053200 0.050000 4.91e-01 5.18e-01
IRS-related events triggered by IGF1R 36 7.61e-01 8.62e-01 0.07280 0.069000 -0.023000 4.74e-01 8.11e-01
HCMV Early Events 84 5.04e-01 6.74e-01 0.07270 0.071700 0.012100 2.56e-01 8.48e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 9.02e-01 9.47e-01 0.07260 0.000299 0.072600 9.99e-01 6.50e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 8.86e-01 9.34e-01 0.07250 -0.010400 -0.071700 9.44e-01 6.31e-01
Base Excision Repair 56 6.43e-01 7.80e-01 0.07250 -0.072500 0.001200 3.48e-01 9.88e-01
Extension of Telomeres 51 6.49e-01 7.86e-01 0.07240 -0.059300 -0.041600 4.64e-01 6.07e-01
Complex I biogenesis 66 5.77e-01 7.29e-01 0.07210 0.064500 0.032200 3.65e-01 6.51e-01
FOXO-mediated transcription 57 6.51e-01 7.88e-01 0.07150 0.070800 -0.009750 3.55e-01 8.99e-01
Cellular response to heat stress 92 5.10e-01 6.79e-01 0.07140 -0.068200 0.021300 2.59e-01 7.24e-01
Collagen biosynthesis and modifying enzymes 45 6.91e-01 8.14e-01 0.07110 -0.054500 -0.045700 5.27e-01 5.96e-01
HIV elongation arrest and recovery 32 7.70e-01 8.66e-01 0.07090 0.054600 0.045300 5.93e-01 6.57e-01
Pausing and recovery of HIV elongation 32 7.70e-01 8.66e-01 0.07090 0.054600 0.045300 5.93e-01 6.57e-01
Nuclear Events (kinase and transcription factor activation) 54 6.63e-01 7.98e-01 0.07060 -0.070300 -0.006010 3.71e-01 9.39e-01
Nucleotide Excision Repair 108 4.75e-01 6.49e-01 0.07050 -0.055900 0.043000 3.16e-01 4.40e-01
Nuclear signaling by ERBB4 24 8.50e-01 9.12e-01 0.06990 -0.051600 0.047200 6.62e-01 6.89e-01
RA biosynthesis pathway 13 9.13e-01 9.52e-01 0.06980 -0.067100 0.019400 6.75e-01 9.03e-01
Metabolism of nucleotides 85 5.39e-01 6.99e-01 0.06950 -0.000252 -0.069500 9.97e-01 2.68e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 9.13e-01 9.52e-01 0.06940 -0.018000 -0.067100 9.14e-01 6.87e-01
HDACs deacetylate histones 45 7.14e-01 8.29e-01 0.06910 -0.018800 -0.066500 8.27e-01 4.40e-01
Glycosaminoglycan metabolism 95 5.22e-01 6.87e-01 0.06900 0.066400 -0.018500 2.63e-01 7.55e-01
Metabolism of folate and pterines 16 8.84e-01 9.33e-01 0.06880 0.049200 0.048100 7.34e-01 7.39e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 8.33e-01 9.00e-01 0.06850 0.065400 -0.020100 5.56e-01 8.56e-01
FGFRL1 modulation of FGFR1 signaling 7 9.53e-01 9.77e-01 0.06840 0.014600 -0.066800 9.47e-01 7.59e-01
RND2 GTPase cycle 36 7.63e-01 8.63e-01 0.06830 -0.035400 -0.058400 7.13e-01 5.44e-01
FGFR2 ligand binding and activation 9 9.41e-01 9.66e-01 0.06690 -0.001540 0.066800 9.94e-01 7.28e-01
Assembly and cell surface presentation of NMDA receptors 30 8.15e-01 8.93e-01 0.06680 0.005420 0.066600 9.59e-01 5.28e-01
Regulation of beta-cell development 21 8.60e-01 9.17e-01 0.06680 0.031300 0.059000 8.04e-01 6.40e-01
Glucose metabolism 76 5.82e-01 7.34e-01 0.06660 -0.058300 -0.032300 3.80e-01 6.27e-01
mRNA Splicing - Minor Pathway 50 7.17e-01 8.32e-01 0.06660 -0.001220 0.066500 9.88e-01 4.16e-01
MyD88 cascade initiated on plasma membrane 95 5.56e-01 7.15e-01 0.06630 0.030500 -0.058900 6.08e-01 3.21e-01
Toll Like Receptor 10 (TLR10) Cascade 95 5.56e-01 7.15e-01 0.06630 0.030500 -0.058900 6.08e-01 3.21e-01
Toll Like Receptor 5 (TLR5) Cascade 95 5.56e-01 7.15e-01 0.06630 0.030500 -0.058900 6.08e-01 3.21e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 8.70e-01 9.26e-01 0.06590 -0.041000 0.051600 7.34e-01 6.68e-01
Circadian Clock 67 6.34e-01 7.73e-01 0.06590 -0.063300 -0.018300 3.71e-01 7.96e-01
Ion channel transport 136 4.06e-01 5.93e-01 0.06530 -0.015900 -0.063300 7.49e-01 2.03e-01
Aerobic respiration and respiratory electron transport 245 2.26e-01 4.14e-01 0.06490 0.063500 -0.013500 8.71e-02 7.15e-01
Activation of NMDA receptors and postsynaptic events 70 6.64e-01 7.98e-01 0.06490 0.041100 -0.050300 5.53e-01 4.67e-01
Class A/1 (Rhodopsin-like receptors) 172 3.69e-01 5.60e-01 0.06480 0.044700 -0.047000 3.12e-01 2.88e-01
Synthesis of PA 31 8.11e-01 8.90e-01 0.06450 -0.038800 -0.051500 7.08e-01 6.20e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 38 8.07e-01 8.88e-01 0.06370 0.044500 -0.045600 6.35e-01 6.27e-01
FOXO-mediated transcription of cell cycle genes 14 9.21e-01 9.56e-01 0.06360 0.061300 -0.017200 6.91e-01 9.11e-01
Cytochrome P450 - arranged by substrate type 33 8.08e-01 8.88e-01 0.06340 -0.055100 -0.031300 5.84e-01 7.56e-01
Phospholipid metabolism 182 3.28e-01 5.21e-01 0.06330 -0.008390 -0.062800 8.45e-01 1.44e-01
Collagen formation 63 6.67e-01 7.99e-01 0.06320 -0.053800 -0.033200 4.60e-01 6.49e-01
Transcriptional Regulation by TP53 343 1.51e-01 3.29e-01 0.06280 0.024600 -0.057800 4.33e-01 6.61e-02
SHC1 events in ERBB2 signaling 17 9.09e-01 9.49e-01 0.06260 0.058500 -0.022300 6.76e-01 8.74e-01
Diseases associated with surfactant metabolism 5 9.73e-01 9.90e-01 0.06240 0.036400 -0.050700 8.88e-01 8.44e-01
FGFR4 ligand binding and activation 5 9.73e-01 9.90e-01 0.06240 -0.044000 0.044200 8.65e-01 8.64e-01
Signaling by ERBB2 44 7.92e-01 8.79e-01 0.06180 0.045500 -0.041900 6.02e-01 6.31e-01
Regulation of TNFR1 signaling 47 7.48e-01 8.55e-01 0.06160 -0.041300 -0.045700 6.24e-01 5.88e-01
GPCR downstream signalling 392 1.15e-01 2.78e-01 0.06120 0.001900 -0.061200 9.49e-01 3.76e-02
MTOR signalling 39 8.11e-01 8.90e-01 0.06100 0.058300 -0.018200 5.29e-01 8.44e-01
Sensory processing of sound by inner hair cells of the cochlea 54 7.36e-01 8.45e-01 0.06090 -0.060600 -0.006680 4.41e-01 9.32e-01
Mitochondrial biogenesis 91 6.21e-01 7.63e-01 0.06090 0.025500 -0.055300 6.74e-01 3.62e-01
tRNA Aminoacylation 42 7.84e-01 8.74e-01 0.06060 -0.057700 -0.018600 5.18e-01 8.34e-01
CDC42 GTPase cycle 139 4.73e-01 6.48e-01 0.06050 0.060100 -0.006350 2.21e-01 8.97e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 9.36e-01 9.63e-01 0.05980 0.020700 -0.056100 8.97e-01 7.26e-01
Epigenetic regulation of gene expression 263 2.31e-01 4.19e-01 0.05980 -0.017700 -0.057100 6.22e-01 1.11e-01
mRNA 3’-end processing 57 7.21e-01 8.35e-01 0.05950 0.034200 0.048700 6.55e-01 5.25e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.94e-01 9.41e-01 0.05910 0.026000 0.053100 8.41e-01 6.81e-01
Adenylate cyclase inhibitory pathway 11 9.49e-01 9.73e-01 0.05820 -0.028200 0.050900 8.71e-01 7.70e-01
Signaling by FGFR2 in disease 33 8.52e-01 9.13e-01 0.05780 0.013300 -0.056300 8.95e-01 5.76e-01
Carboxyterminal post-translational modifications of tubulin 33 8.38e-01 9.03e-01 0.05750 0.045400 0.035300 6.52e-01 7.26e-01
Regulation of HSF1-mediated heat shock response 78 6.68e-01 7.99e-01 0.05730 -0.054100 -0.018900 4.09e-01 7.73e-01
Inflammasomes 21 9.09e-01 9.49e-01 0.05700 -0.029000 0.049100 8.18e-01 6.97e-01
RNA Polymerase II Transcription Termination 66 7.17e-01 8.32e-01 0.05670 0.014900 0.054700 8.34e-01 4.42e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.76e-01 9.29e-01 0.05640 -0.008690 -0.055700 9.38e-01 6.16e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.76e-01 9.29e-01 0.05640 -0.008690 -0.055700 9.38e-01 6.16e-01
Biosynthesis of E-series 18(S)-resolvins 5 9.78e-01 9.92e-01 0.05630 0.042100 -0.037400 8.70e-01 8.85e-01
ERK/MAPK targets 22 9.03e-01 9.47e-01 0.05620 0.055500 -0.009380 6.53e-01 9.39e-01
RNA polymerase II transcribes snRNA genes 71 7.04e-01 8.24e-01 0.05590 -0.019500 -0.052400 7.77e-01 4.45e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 8.20e-01 8.95e-01 0.05530 -0.054700 0.008130 5.30e-01 9.26e-01
Toll Like Receptor 9 (TLR9) Cascade 108 5.99e-01 7.48e-01 0.05510 -0.014600 -0.053200 7.94e-01 3.40e-01
Glycerophospholipid biosynthesis 104 6.41e-01 7.79e-01 0.05510 0.049700 -0.023800 3.81e-01 6.75e-01
NCAM signaling for neurite out-growth 47 8.00e-01 8.83e-01 0.05490 -0.052400 -0.016400 5.34e-01 8.46e-01
FGFR2b ligand binding and activation 6 9.75e-01 9.91e-01 0.05480 0.038400 -0.039100 8.71e-01 8.68e-01
Arachidonate metabolism 42 8.32e-01 9.00e-01 0.05460 0.053800 -0.009360 5.46e-01 9.16e-01
Signaling by ROBO receptors 189 4.45e-01 6.22e-01 0.05350 0.053500 -0.000117 2.05e-01 9.98e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 8.30e-01 8.99e-01 0.05220 0.032600 0.040800 7.14e-01 6.48e-01
HIV Transcription Elongation 42 8.30e-01 8.99e-01 0.05220 0.032600 0.040800 7.14e-01 6.48e-01
Tat-mediated elongation of the HIV-1 transcript 42 8.30e-01 8.99e-01 0.05220 0.032600 0.040800 7.14e-01 6.48e-01
Gene Silencing by RNA 87 7.13e-01 8.29e-01 0.05220 0.017000 -0.049300 7.84e-01 4.26e-01
Transcriptional regulation by small RNAs 61 7.71e-01 8.66e-01 0.05210 0.050400 0.013500 4.96e-01 8.55e-01
Myogenesis 20 9.16e-01 9.55e-01 0.05180 -0.038700 -0.034500 7.65e-01 7.89e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 9.31e-01 9.61e-01 0.05180 -0.049400 -0.015600 7.25e-01 9.11e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 8.29e-01 8.99e-01 0.05140 0.042600 0.028600 6.25e-01 7.43e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 9.82e-01 9.94e-01 0.05140 -0.023800 0.045500 9.27e-01 8.60e-01
Diseases of glycosylation 104 6.58e-01 7.93e-01 0.05130 0.006610 0.050800 9.07e-01 3.70e-01
Chromatin modifying enzymes 213 4.42e-01 6.19e-01 0.05020 -0.050000 -0.004890 2.09e-01 9.02e-01
Chromatin organization 213 4.42e-01 6.19e-01 0.05020 -0.050000 -0.004890 2.09e-01 9.02e-01
SUMOylation of transcription cofactors 44 8.41e-01 9.05e-01 0.04990 0.016300 0.047200 8.52e-01 5.88e-01
WNT5A-dependent internalization of FZD4 13 9.54e-01 9.77e-01 0.04990 0.048500 -0.011700 7.62e-01 9.42e-01
Formation of Incision Complex in GG-NER 43 8.56e-01 9.14e-01 0.04980 0.048500 -0.011400 5.82e-01 8.97e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 6.76e-01 8.05e-01 0.04970 -0.002480 -0.049600 9.65e-01 3.80e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 9.66e-01 9.87e-01 0.04870 -0.022100 -0.043400 9.09e-01 8.22e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 9.80e-01 9.94e-01 0.04840 -0.041900 0.024100 8.59e-01 9.19e-01
Formation of axial mesoderm 6 9.78e-01 9.92e-01 0.04800 0.041600 0.023900 8.60e-01 9.19e-01
Sensory processing of sound 57 8.11e-01 8.90e-01 0.04780 -0.041700 -0.023400 5.86e-01 7.60e-01
Signaling by GPCR 435 2.31e-01 4.19e-01 0.04740 -0.004460 -0.047200 8.73e-01 9.18e-02
SARS-CoV-2 Infection 263 4.27e-01 6.05e-01 0.04680 0.002380 -0.046700 9.47e-01 1.92e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 9.31e-01 9.61e-01 0.04660 0.044400 0.014100 7.25e-01 9.11e-01
Formation of TC-NER Pre-Incision Complex 51 8.61e-01 9.18e-01 0.04580 0.025500 -0.038100 7.53e-01 6.38e-01
GPCR ligand binding 235 5.24e-01 6.88e-01 0.04460 0.023400 -0.037900 5.36e-01 3.17e-01
Acyl chain remodelling of PE 19 9.42e-01 9.66e-01 0.04410 0.029100 0.033200 8.26e-01 8.02e-01
Sensory processing of sound by outer hair cells of the cochlea 40 8.82e-01 9.30e-01 0.04400 0.028900 0.033200 7.52e-01 7.16e-01
SARS-CoV-1-host interactions 94 7.76e-01 8.69e-01 0.04370 -0.018600 0.039600 7.55e-01 5.08e-01
Late Phase of HIV Life Cycle 131 6.94e-01 8.14e-01 0.04370 0.007630 -0.043000 8.80e-01 3.95e-01
Nuclear Envelope Breakdown 53 8.54e-01 9.13e-01 0.04330 -0.039700 -0.017200 6.17e-01 8.28e-01
Retinoid metabolism and transport 23 9.34e-01 9.62e-01 0.04330 -0.040900 -0.014200 7.34e-01 9.06e-01
MyD88 dependent cascade initiated on endosome 101 7.50e-01 8.55e-01 0.04280 -0.008550 -0.042000 8.82e-01 4.66e-01
Stimuli-sensing channels 78 7.94e-01 8.79e-01 0.04280 -0.034600 -0.025100 5.97e-01 7.02e-01
TP53 Regulates Transcription of DNA Repair Genes 61 8.38e-01 9.03e-01 0.04220 -0.032700 -0.026700 6.58e-01 7.19e-01
VEGFR2 mediated vascular permeability 25 9.38e-01 9.64e-01 0.04200 -0.008580 0.041100 9.41e-01 7.22e-01
Effects of PIP2 hydrolysis 24 9.33e-01 9.62e-01 0.04200 0.028200 0.031100 8.11e-01 7.92e-01
Glycolysis 68 8.29e-01 8.99e-01 0.04160 -0.016200 -0.038300 8.17e-01 5.85e-01
NOD1/2 Signaling Pathway 36 9.15e-01 9.54e-01 0.04080 0.004310 -0.040500 9.64e-01 6.74e-01
Recycling of eIF2:GDP 8 9.82e-01 9.94e-01 0.03990 0.017400 -0.035900 9.32e-01 8.60e-01
PI3K/AKT Signaling in Cancer 83 8.11e-01 8.90e-01 0.03980 0.016600 0.036200 7.94e-01 5.69e-01
CD28 co-stimulation 33 9.20e-01 9.56e-01 0.03950 -0.028800 -0.027100 7.75e-01 7.88e-01
Metabolism of RNA 717 1.72e-01 3.55e-01 0.03950 0.028300 0.027500 1.98e-01 2.09e-01
FLT3 signaling through SRC family kinases 6 9.86e-01 9.96e-01 0.03940 -0.006600 -0.038900 9.78e-01 8.69e-01
HIV Life Cycle 144 7.05e-01 8.24e-01 0.03900 -0.017700 -0.034800 7.14e-01 4.72e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 9.72e-01 9.90e-01 0.03900 0.012800 -0.036800 9.36e-01 8.18e-01
Elastic fibre formation 33 9.33e-01 9.62e-01 0.03860 -0.035400 0.015500 7.25e-01 8.78e-01
RMTs methylate histone arginines 35 9.23e-01 9.56e-01 0.03830 0.008270 0.037400 9.32e-01 7.02e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 9.72e-01 9.90e-01 0.03820 -0.028200 0.025700 8.55e-01 8.68e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 9.72e-01 9.90e-01 0.03820 -0.028200 0.025700 8.55e-01 8.68e-01
mRNA Splicing 211 6.12e-01 7.57e-01 0.03810 -0.030500 -0.022700 4.45e-01 5.70e-01
p75 NTR receptor-mediated signalling 89 8.20e-01 8.95e-01 0.03790 -0.008050 -0.037100 8.96e-01 5.46e-01
Regulation of MITF-M-dependent genes involved in pigmentation 35 9.24e-01 9.56e-01 0.03740 0.023700 0.028900 8.08e-01 7.67e-01
Processing of Capped Intronless Pre-mRNA 29 9.39e-01 9.65e-01 0.03670 0.017400 0.032300 8.71e-01 7.63e-01
Cell death signalling via NRAGE, NRIF and NADE 69 8.75e-01 9.29e-01 0.03600 0.001810 -0.035900 9.79e-01 6.06e-01
Biological oxidations 135 7.66e-01 8.65e-01 0.03590 0.005030 0.035600 9.20e-01 4.76e-01
Neurotransmitter release cycle 38 9.24e-01 9.56e-01 0.03580 -0.025900 -0.024800 7.82e-01 7.92e-01
Biosynthesis of EPA-derived SPMs 6 9.90e-01 9.96e-01 0.03530 -0.022300 0.027400 9.25e-01 9.08e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 9.76e-01 9.91e-01 0.03520 -0.017500 -0.030600 9.16e-01 8.54e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 9.04e-01 9.47e-01 0.03450 0.001410 -0.034500 9.85e-01 6.53e-01
Signaling by FGFR2 IIIa TM 18 9.71e-01 9.90e-01 0.03410 0.023200 -0.025000 8.65e-01 8.55e-01
mRNA Splicing - Major Pathway 203 6.89e-01 8.14e-01 0.03400 -0.030900 -0.014200 4.47e-01 7.28e-01
Protein localization 157 7.57e-01 8.60e-01 0.03400 0.005680 0.033500 9.02e-01 4.69e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.89e-01 9.96e-01 0.03340 0.022300 0.024900 9.25e-01 9.16e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.89e-01 9.96e-01 0.03340 0.022300 0.024900 9.25e-01 9.16e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 8.47e-01 9.11e-01 0.03290 -0.004340 -0.032600 9.40e-01 5.73e-01
TYSND1 cleaves peroxisomal proteins 7 9.88e-01 9.96e-01 0.03260 -0.006910 -0.031900 9.75e-01 8.84e-01
Metabolism 1805 7.89e-02 2.15e-01 0.03240 0.006100 -0.031800 6.68e-01 2.51e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 9.22e-01 9.56e-01 0.03220 -0.003800 0.031900 9.62e-01 6.88e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 9.22e-01 9.56e-01 0.03220 -0.003800 0.031900 9.62e-01 6.88e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 9.22e-01 9.56e-01 0.03220 -0.003800 0.031900 9.62e-01 6.88e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 9.22e-01 9.56e-01 0.03220 -0.003800 0.031900 9.62e-01 6.88e-01
Signaling by NOTCH1 in Cancer 53 9.22e-01 9.56e-01 0.03220 -0.003800 0.031900 9.62e-01 6.88e-01
FGFR2 mutant receptor activation 23 9.67e-01 9.87e-01 0.03220 -0.014300 0.028800 9.05e-01 8.11e-01
O-linked glycosylation 81 8.81e-01 9.30e-01 0.03200 -0.003180 -0.031900 9.60e-01 6.20e-01
Processing of Capped Intron-Containing Pre-mRNA 279 6.53e-01 7.90e-01 0.03150 -0.030600 -0.007230 3.79e-01 8.35e-01
Cytosolic sensors of pathogen-associated DNA 63 9.09e-01 9.49e-01 0.03060 0.019700 0.023300 7.87e-01 7.49e-01
SLC-mediated transmembrane transport 171 8.00e-01 8.83e-01 0.03040 0.013000 -0.027500 7.70e-01 5.35e-01
Metabolism of cofactors 25 9.69e-01 9.89e-01 0.03000 -0.016800 0.024800 8.84e-01 8.30e-01
Translesion Synthesis by POLH 18 9.74e-01 9.90e-01 0.02990 -0.024600 -0.017100 8.57e-01 9.00e-01
Potassium Channels 61 9.27e-01 9.58e-01 0.02980 0.025300 -0.015800 7.32e-01 8.31e-01
Formation of the Early Elongation Complex 33 9.55e-01 9.77e-01 0.02930 0.015100 0.025200 8.81e-01 8.02e-01
Formation of the HIV-1 Early Elongation Complex 33 9.55e-01 9.77e-01 0.02930 0.015100 0.025200 8.81e-01 8.02e-01
Metabolism of carbohydrates 236 7.53e-01 8.59e-01 0.02870 0.028400 -0.004460 4.53e-01 9.06e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 9.07e-01 9.49e-01 0.02870 0.016900 0.023200 8.03e-01 7.32e-01
Assembly of collagen fibrils and other multimeric structures 41 9.54e-01 9.77e-01 0.02810 -0.027000 0.008050 7.65e-01 9.29e-01
Diseases of metabolism 198 7.93e-01 8.79e-01 0.02690 0.016400 0.021400 6.92e-01 6.03e-01
Relaxin receptors 5 9.95e-01 9.99e-01 0.02690 0.021200 -0.016600 9.35e-01 9.49e-01
Endosomal/Vacuolar pathway 11 9.89e-01 9.96e-01 0.02540 0.019100 0.016700 9.12e-01 9.24e-01
Metabolism of amino acids and derivatives 303 7.33e-01 8.43e-01 0.02530 0.020000 0.015500 5.50e-01 6.43e-01
Regulation of NF-kappa B signaling 18 9.84e-01 9.95e-01 0.02490 0.022300 -0.011000 8.70e-01 9.35e-01
RUNX2 regulates osteoblast differentiation 16 9.87e-01 9.96e-01 0.02380 0.021500 -0.010400 8.82e-01 9.43e-01
TAK1-dependent IKK and NF-kappa-B activation 43 9.65e-01 9.86e-01 0.02370 -0.023600 0.002100 7.89e-01 9.81e-01
Neuronal System 261 8.23e-01 8.97e-01 0.02310 0.010500 -0.020600 7.69e-01 5.67e-01
Branched-chain amino acid catabolism 21 9.84e-01 9.95e-01 0.02210 -0.003330 -0.021900 9.79e-01 8.62e-01
Regulation of TP53 Activity 151 9.04e-01 9.47e-01 0.02180 0.007680 -0.020400 8.71e-01 6.66e-01
Plasma lipoprotein assembly 10 9.94e-01 9.99e-01 0.02030 0.014500 -0.014200 9.37e-01 9.38e-01
Free fatty acids regulate insulin secretion 10 9.95e-01 9.99e-01 0.01950 -0.012200 0.015200 9.47e-01 9.34e-01
mRNA Capping 29 9.88e-01 9.96e-01 0.01750 0.013100 -0.011700 9.03e-01 9.13e-01
Signaling by NOTCH1 66 9.82e-01 9.94e-01 0.01370 -0.013700 -0.000148 8.48e-01 9.98e-01
Acyl chain remodelling of PS 14 9.96e-01 9.99e-01 0.01360 0.010700 -0.008310 9.45e-01 9.57e-01
Synthesis of substrates in N-glycan biosythesis 58 9.85e-01 9.95e-01 0.01290 0.008390 0.009770 9.12e-01 8.98e-01
Histidine catabolism 7 9.98e-01 9.99e-01 0.01260 -0.003870 -0.012000 9.86e-01 9.56e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 9.98e-01 9.99e-01 0.01250 -0.012200 -0.003070 9.56e-01 9.89e-01
Regulation of signaling by NODAL 6 9.99e-01 9.99e-01 0.01180 0.011500 0.002780 9.61e-01 9.91e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 9.90e-01 9.96e-01 0.01110 0.009200 -0.006160 9.05e-01 9.36e-01
HDL assembly 6 9.99e-01 9.99e-01 0.00906 0.008900 0.001720 9.70e-01 9.94e-01
rRNA modification in the mitochondrion 8 9.99e-01 9.99e-01 0.00858 0.008360 -0.001930 9.67e-01 9.92e-01
Metabolism of fat-soluble vitamins 26 9.98e-01 9.99e-01 0.00760 -0.006070 0.004580 9.57e-01 9.68e-01
Maturation of TCA enzymes and regulation of TCA cycle 20 9.99e-01 9.99e-01 0.00547 0.005190 -0.001740 9.68e-01 9.89e-01


Detailed Gene set reports


Protein repair
Protein repair
metric value
setSize 6
pMANOVA 0.000306
p.adjustMANOVA 0.00294
s.dist 0.985
s.dex_eos_adj 0.743
s.dex_pod1_adj -0.646
p.dex_eos_adj 0.00161
p.dex_pod1_adj 0.00611



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
TXN 8065 -9432
MSRB3 8479 -8203
PCMT1 6725 -9678
MSRA 5056 -9674
MSRB1 5941 -7621

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
MSRA 5056 -9674
MSRB1 5941 -7621
MSRB2 7851 1223
MSRB3 8479 -8203
PCMT1 6725 -9678
TXN 8065 -9432



G2/M DNA replication checkpoint
G2/M DNA replication checkpoint
metric value
setSize 5
pMANOVA 0.00345
p.adjustMANOVA 0.0216
s.dist 0.903
s.dex_eos_adj 0.601
s.dex_pod1_adj -0.674
p.dex_eos_adj 0.0199
p.dex_pod1_adj 0.00903



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
CCNB1 4754 -10081
CCNB2 5287 -8987
WEE1 9378 -3451
CDK1 2568 -10819
PKMYT1 5606 -4291

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CCNB1 4754 -10081
CCNB2 5287 -8987
CDK1 2568 -10819
PKMYT1 5606 -4291
WEE1 9378 -3451



Neurotransmitter clearance
Neurotransmitter clearance
metric value
setSize 6
pMANOVA 0.000709
p.adjustMANOVA 0.00563
s.dist 0.864
s.dex_eos_adj 0.462
s.dex_pod1_adj 0.73
p.dex_eos_adj 0.05
p.dex_pod1_adj 0.00195



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
MAOA 9462 9997
ALDH2 6964 9947
SLC22A1 5508 9821
COMT 4966 6587

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
ALDH2 6964 9947
COMT 4966 6587
LRTOMT -11082 7586
MAOA 9462 9997
SLC22A1 5508 9821
SLC6A4 8472 -94



Interleukin-21 signaling
Interleukin-21 signaling
metric value
setSize 9
pMANOVA 3.94e-05
p.adjustMANOVA 0.000548
s.dist 0.832
s.dex_eos_adj -0.512
s.dex_pod1_adj -0.656
p.dex_eos_adj 0.00784
p.dex_pod1_adj 0.000648



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
IL21R -11174 -10185
STAT1 -9278 -10868
IL2RG -10177 -8018
STAT4 -8244 -6515
JAK3 -4937 -10599
STAT5B -9848 -3321

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
IL21R -11174 -10185
IL2RG -10177 -8018
JAK1 930 -9127
JAK3 -4937 -10599
STAT1 -9278 -10868
STAT3 5538 -9846
STAT4 -8244 -6515
STAT5A -8927 2446
STAT5B -9848 -3321



Response to metal ions
Response to metal ions
metric value
setSize 6
pMANOVA 0.00339
p.adjustMANOVA 0.0214
s.dist 0.825
s.dex_eos_adj 0.5
s.dex_pod1_adj -0.656
p.dex_eos_adj 0.0341
p.dex_pod1_adj 0.00537



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
MT1X 7797 -9490
MT2A 9494 -5308
MT1E 8920 -4902
CSRP1 4490 -8322
MT1F 5203 -7082

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CSRP1 4490 -8322
MT1E 8920 -4902
MT1F 5203 -7082
MT1X 7797 -9490
MT2A 9494 -5308
MTF1 -9236 -8914



Tandem pore domain potassium channels
Tandem pore domain potassium channels
metric value
setSize 5
pMANOVA 0.00496
p.adjustMANOVA 0.0278
s.dist 0.81
s.dex_eos_adj -0.685
s.dex_pod1_adj -0.432
p.dex_eos_adj 0.008
p.dex_pod1_adj 0.0942



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
KCNK10 -10834 -10824
KCNK17 -8042 -10690
KCNK13 -6385 -9564
KCNK6 -10989 -2269

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
KCNK10 -10834 -10824
KCNK13 -6385 -9564
KCNK17 -8042 -10690
KCNK6 -10989 -2269
KCNK7 -4070 8495



Fructose metabolism
Fructose metabolism
metric value
setSize 7
pMANOVA 0.00172
p.adjustMANOVA 0.012
s.dist 0.804
s.dex_eos_adj -0.389
s.dex_pod1_adj 0.703
p.dex_eos_adj 0.0746
p.dex_pod1_adj 0.00127



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ALDH1A1 -8990 10128
KHK -8358 9219
SORD -11081 6349
AKR1B1 -5225 9534
TKFC -3875 9978

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
AKR1B1 -5225 9534
ALDH1A1 -8990 10128
ALDOB -583 -65
GLYCTK 3527 4022
KHK -8358 9219
SORD -11081 6349
TKFC -3875 9978



CD163 mediating an anti-inflammatory response
CD163 mediating an anti-inflammatory response
metric value
setSize 8
pMANOVA 0.000531
p.adjustMANOVA 0.00451
s.dist 0.786
s.dex_eos_adj 0.783
s.dex_pod1_adj 0.0583
p.dex_eos_adj 0.000124
p.dex_pod1_adj 0.775



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
CD163 9727 8912
PLK2 5320 8507
RHBDF2 9130 3411

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
ADAM17 9208 -914
CD163 9727 8912
FURIN 8534 -268
IL10 8407 -994
MAPK14 1471 -10582
MYH9 7742 -6390
PLK2 5320 8507
RHBDF2 9130 3411



Activation of caspases through apoptosome-mediated cleavage
Activation of caspases through apoptosome-mediated cleavage
metric value
setSize 6
pMANOVA 0.00386
p.adjustMANOVA 0.0236
s.dist 0.781
s.dex_eos_adj -0.0288
s.dex_pod1_adj -0.781
p.dex_eos_adj 0.903
p.dex_pod1_adj 0.000928



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP9 -6038 -9449
XIAP -2635 -10021

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP3 352 -10505
CASP7 3761 -7270
CASP9 -6038 -9449
CYCS 7210 -5754
XIAP -2635 -10021



RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in BCR signaling
metric value
setSize 6
pMANOVA 0.00665
p.adjustMANOVA 0.0348
s.dist 0.769
s.dex_eos_adj 0.689
s.dex_pod1_adj -0.342
p.dex_eos_adj 0.00348
p.dex_pod1_adj 0.147



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
RUNX1 5436 -10692
CBFB 5033 -9414
ELF1 8541 -4703
PAX5 5470 -1615
ELF2 6113 -1165

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
BLK 8068 3498
CBFB 5033 -9414
ELF1 8541 -4703
ELF2 6113 -1165
PAX5 5470 -1615
RUNX1 5436 -10692



MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription of neuronal ligands
metric value
setSize 5
pMANOVA 0.00995
p.adjustMANOVA 0.0472
s.dist 0.764
s.dex_eos_adj -0.727
s.dex_pod1_adj -0.234
p.dex_eos_adj 0.00485
p.dex_pod1_adj 0.365



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
HDAC1 -11102 -8624
DLL1 -7618 -6140
CREB1 -6492 -4091

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CREB1 -6492 -4091
DLL1 -7618 -6140
HDAC1 -11102 -8624
MECP2 -9285 495
SIN3A -8070 3991



ARMS-mediated activation
ARMS-mediated activation
metric value
setSize 6
pMANOVA 0.00969
p.adjustMANOVA 0.0463
s.dist 0.738
s.dex_eos_adj 0.296
s.dex_pod1_adj -0.675
p.dex_eos_adj 0.209
p.dex_pod1_adj 0.00417



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
RAP1A 9040 -7095
KIDINS220 2405 -7414
CRK 3341 -4146
BRAF 1001 -5923

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
BRAF 1001 -5923
CRK 3341 -4146
KIDINS220 2405 -7414
NTRK1 -1897 -10936
RAP1A 9040 -7095
YWHAB -96 -9715



G2 Phase
G2 Phase
metric value
setSize 5
pMANOVA 0.023
p.adjustMANOVA 0.0924
s.dist 0.734
s.dex_eos_adj 0.614
s.dex_pod1_adj -0.403
p.dex_eos_adj 0.0174
p.dex_pod1_adj 0.119



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
CCNA1 9533 -10715
E2F3 9441 -4437
CCNA2 3797 -10027
E2F1 6137 -4507

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CCNA1 9533 -10715
CCNA2 3797 -10027
CDK2 -618 6403
E2F1 6137 -4507
E2F3 9441 -4437



Defective binding of VWF variant to GPIb:IX:V
Defective binding of VWF variant to GPIb:IX:V
metric value
setSize 5
pMANOVA 0.019
p.adjustMANOVA 0.0791
s.dist 0.734
s.dex_eos_adj 0.724
s.dex_pod1_adj -0.121
p.dex_eos_adj 0.00504
p.dex_pod1_adj 0.64



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
GP1BB 8385 -5284
VWF 8000 -3791
GP9 9013 -1307
GP5 1874 -5302

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
GP1BA 6813 7276
GP1BB 8385 -5284
GP5 1874 -5302
GP9 9013 -1307
VWF 8000 -3791



Enhanced binding of GP1BA variant to VWF multimer:collagen
Enhanced binding of GP1BA variant to VWF multimer:collagen
metric value
setSize 5
pMANOVA 0.019
p.adjustMANOVA 0.0791
s.dist 0.734
s.dex_eos_adj 0.724
s.dex_pod1_adj -0.121
p.dex_eos_adj 0.00504
p.dex_pod1_adj 0.64



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
GP1BB 8385 -5284
VWF 8000 -3791
GP9 9013 -1307
GP5 1874 -5302

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
GP1BA 6813 7276
GP1BB 8385 -5284
GP5 1874 -5302
GP9 9013 -1307
VWF 8000 -3791



NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
metric value
setSize 5
pMANOVA 0.0239
p.adjustMANOVA 0.0957
s.dist 0.73
s.dex_eos_adj -0.378
s.dex_pod1_adj 0.624
p.dex_eos_adj 0.143
p.dex_pod1_adj 0.0157



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
NR1H3 -10873 9411
RXRA -10819 4525
RXRB -9176 4502
NR1H2 -2603 2540

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
MYLIP 9336 9951
NR1H2 -2603 2540
NR1H3 -10873 9411
RXRA -10819 4525
RXRB -9176 4502



ROBO receptors bind AKAP5
ROBO receptors bind AKAP5
metric value
setSize 7
pMANOVA 0.00262
p.adjustMANOVA 0.0172
s.dist 0.724
s.dex_eos_adj -0.409
s.dex_pod1_adj -0.597
p.dex_eos_adj 0.0612
p.dex_pod1_adj 0.00622



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
AKAP5 -10878 -10286
PRKAR2A -6952 -10188
PRKCA -4813 -10854
PRKACB -6583 -6850
PPP3CB -1118 -10482

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
AKAP5 -10878 -10286
PPP3CB -1118 -10482
PRKACA 2296 -709
PRKACB -6583 -6850
PRKAR2A -6952 -10188
PRKCA -4813 -10854
ROBO3 -7974 2391



Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of NIMA Kinases NEK9, NEK6, NEK7
metric value
setSize 7
pMANOVA 0.00483
p.adjustMANOVA 0.0273
s.dist 0.721
s.dex_eos_adj 0.136
s.dex_pod1_adj -0.708
p.dex_eos_adj 0.534
p.dex_pod1_adj 0.00117



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
CCNB1 4754 -10081
CCNB2 5287 -8987
NEK9 3954 -9550
CDK1 2568 -10819
NEK7 2425 -8756

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CCNB1 4754 -10081
CCNB2 5287 -8987
CDK1 2568 -10819
NEK6 -10715 -318
NEK7 2425 -8756
NEK9 3954 -9550
PLK1 -4051 -6685



Butyrophilin (BTN) family interactions
Butyrophilin (BTN) family interactions
metric value
setSize 9
pMANOVA 0.00127
p.adjustMANOVA 0.0093
s.dist 0.72
s.dex_eos_adj -0.259
s.dex_pod1_adj 0.672
p.dex_eos_adj 0.178
p.dex_pod1_adj 0.000479



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
BTN2A2 -9060 10011
CD209 -10842 7693
BTN3A3 -10268 5869
BTN3A1 -5360 9797
BTN2A1 -5184 9284
BTN3A2 -4331 2890

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
BTN2A1 -5184 9284
BTN2A2 -9060 10011
BTN3A1 -5360 9797
BTN3A2 -4331 2890
BTN3A3 -10268 5869
BTNL8 6348 9143
BTNL9 634 -1011
CD209 -10842 7693
PPL 5961 6558



Fructose catabolism
Fructose catabolism
metric value
setSize 5
pMANOVA 0.0248
p.adjustMANOVA 0.0976
s.dist 0.72
s.dex_eos_adj -0.267
s.dex_pod1_adj 0.669
p.dex_eos_adj 0.3
p.dex_pod1_adj 0.00962



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ALDH1A1 -8990 10128
KHK -8358 9219
TKFC -3875 9978

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
ALDH1A1 -8990 10128
ALDOB -583 -65
GLYCTK 3527 4022
KHK -8358 9219
TKFC -3875 9978



Regulation of IFNA/IFNB signaling
Regulation of IFNA/IFNB signaling
metric value
setSize 12
pMANOVA 7.49e-05
p.adjustMANOVA 0.00091
s.dist 0.709
s.dex_eos_adj -0.204
s.dex_pod1_adj -0.679
p.dex_eos_adj 0.221
p.dex_pod1_adj 4.65e-05



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
IFNAR2 -11354 -10298
SOCS3 -10608 -10362
STAT1 -9278 -10868
IFNAR1 -8472 -10273
STAT2 -8643 -7342
PTPN6 -2162 -4452
USP18 -970 -8775

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
IFNAR1 -8472 -10273
IFNAR2 -11354 -10298
JAK1 930 -9127
PTPN1 9454 -10254
PTPN11 3586 -8658
PTPN6 -2162 -4452
SOCS1 9608 -9066
SOCS3 -10608 -10362
STAT1 -9278 -10868
STAT2 -8643 -7342
TYK2 -7891 8603
USP18 -970 -8775



FASTK family proteins regulate processing and stability of mitochondrial RNAs
FASTK family proteins regulate processing and stability of mitochondrial RNAs
metric value
setSize 19
pMANOVA 4e-07
p.adjustMANOVA 1.01e-05
s.dist 0.705
s.dex_eos_adj 0.69
s.dex_pod1_adj 0.147
p.dex_eos_adj 1.91e-07
p.dex_pod1_adj 0.268



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
MT-CO1 7108 7944
TBRG4 8027 5643
MT-ND2 8917 4215
MT-CO2 7950 4197
MT-CYB 8539 3514
MT-ND4 8356 2661
FASTKD5 7832 2592
MT-ND5 8599 2312
MT-ND3 7715 1055
MT-ND1 8982 744
MT-CO3 7152 171

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
FASTK -1867 3303
FASTKD2 -7263 3881
FASTKD5 7832 2592
MT-ATP6 8156 -11
MT-ATP8 2182 -1560
MT-CO1 7108 7944
MT-CO2 7950 4197
MT-CO3 7152 171
MT-CYB 8539 3514
MT-ND1 8982 744
MT-ND2 8917 4215
MT-ND3 7715 1055
MT-ND4 8356 2661
MT-ND4L 7218 -675
MT-ND5 8599 2312
MT-ND6 7113 -210
MT-RNR1 8771 -8190
MT-RNR2 9085 -9822
TBRG4 8027 5643



Replacement of protamines by nucleosomes in the male pronucleus
Replacement of protamines by nucleosomes in the male pronucleus
metric value
setSize 12
pMANOVA 0.000268
p.adjustMANOVA 0.00273
s.dist 0.696
s.dex_eos_adj 0.628
s.dex_pod1_adj -0.3
p.dex_eos_adj 0.000166
p.dex_pod1_adj 0.0718



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
H3-3A 6994 -9887
H2BC21 9282 -7392
H2BC17 8900 -6092
H2BC15 8816 -5352
H2BC11 9273 -4439
H2BC9 9392 -3138
H2BC12 9102 -1880
H2BC4 9301 -836
METTL23 310 -1270

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
H2BC11 9273 -4439
H2BC12 9102 -1880
H2BC15 8816 -5352
H2BC17 8900 -6092
H2BC21 9282 -7392
H2BC4 9301 -836
H2BC5 8998 7995
H2BC9 9392 -3138
H3-3A 6994 -9887
HIRA -8137 -996
METTL23 310 -1270
SRPK1 -2660 -9607



Establishment of Sister Chromatid Cohesion
Establishment of Sister Chromatid Cohesion
metric value
setSize 11
pMANOVA 0.000384
p.adjustMANOVA 0.00348
s.dist 0.69
s.dex_eos_adj 0.015
s.dex_pod1_adj -0.689
p.dex_eos_adj 0.931
p.dex_pod1_adj 7.51e-05



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ESCO2 6147 -10290
PDS5A 6546 -9137
CDCA5 4323 -9917
WAPL 3512 -7765
RAD21 670 -6447

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CDCA5 4323 -9917
ESCO1 -2553 -9275
ESCO2 6147 -10290
PDS5A 6546 -9137
PDS5B -6914 -2057
RAD21 670 -6447
SMC1A -3456 -4318
SMC3 -8014 -8549
STAG1 -2876 -7883
STAG2 -4782 -8884
WAPL 3512 -7765



CD22 mediated BCR regulation
CD22 mediated BCR regulation
metric value
setSize 57
pMANOVA 5.61e-17
p.adjustMANOVA 5.39e-15
s.dist 0.688
s.dex_eos_adj 0.519
s.dex_pod1_adj -0.451
p.dex_eos_adj 1.19e-11
p.dex_pod1_adj 3.83e-09



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
IGKV4-1 6840 -10340
IGHV4-34 6901 -9680
IGHV3-33 6711 -9418
IGKV3-15 6126 -10116
IGHV2-5 9003 -6474
IGHV3-23 7433 -7815
IGKC 7587 -7654
IGHV3-13 8459 -6854
IGHV1-2 6083 -9150
IGHV4-59 5844 -9463
IGKV1-5 5963 -8758
IGKV1D-39 5405 -9149
IGKV1-17 5389 -8856
IGKV3-20 4567 -9833
IGKV1-16 7441 -5982
IGHV1-69 5887 -7372
IGLC2 5350 -7832
IGLV1-51 7630 -5251
IGHV3-7 7594 -4879
IGLV3-27 4654 -7597

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CD22 4771 -815
CD79A 7273 -1128
CD79B -3866 -5481
IGHD 6591 6216
IGHM 7560 -3560
IGHV1-2 6083 -9150
IGHV1-46 4687 -5771
IGHV1-69 5887 -7372
IGHV2-5 9003 -6474
IGHV2-70 3852 -8401
IGHV3-11 5149 -234
IGHV3-13 8459 -6854
IGHV3-23 7433 -7815
IGHV3-30 1359 -621
IGHV3-33 6711 -9418
IGHV3-48 7066 -2583
IGHV3-53 6878 358
IGHV3-7 7594 -4879
IGHV4-34 6901 -9680
IGHV4-39 102 -10332
IGHV4-59 5844 -9463
IGKC 7587 -7654
IGKV1-12 5882 505
IGKV1-16 7441 -5982
IGKV1-17 5389 -8856
IGKV1-33 8184 -486
IGKV1-5 5963 -8758
IGKV1D-39 5405 -9149
IGKV2-28 4578 -7532
IGKV2-29 4275 2943
IGKV2-30 8396 7524
IGKV2D-28 2970 -4073
IGKV3-11 7388 -2015
IGKV3-15 6126 -10116
IGKV3-20 4567 -9833
IGKV3D-20 824 -5777
IGKV4-1 6840 -10340
IGLC1 7618 976
IGLC2 5350 -7832
IGLC3 6141 -1471
IGLV1-40 5163 -5419
IGLV1-44 8795 724
IGLV1-47 -2018 -8743
IGLV1-51 7630 -5251
IGLV2-11 5654 -1456
IGLV2-14 -1478 -9341
IGLV2-23 8129 -630
IGLV2-8 4073 -4267
IGLV3-1 -5393 -7792
IGLV3-19 6074 -3191
IGLV3-21 -2550 -9908
IGLV3-25 1194 -10417
IGLV3-27 4654 -7597
IGLV6-57 1642 -7393
IGLV7-43 5044 -6845
LYN -6375 -10553
PTPN6 -2162 -4452



LTC4-CYSLTR mediated IL4 production
LTC4-CYSLTR mediated IL4 production
metric value
setSize 5
pMANOVA 0.0222
p.adjustMANOVA 0.0901
s.dist 0.686
s.dex_eos_adj -0.573
s.dex_pod1_adj -0.377
p.dex_eos_adj 0.0266
p.dex_pod1_adj 0.144



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
CYSLTR1 -10637 -9874
GGT5 -8486 -10447
CYSLTR2 -11288 -1148
GGT1 -929 -10192

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CYSLTR1 -10637 -9874
CYSLTR2 -11288 -1148
DPEP2 -3056 9718
GGT1 -929 -10192
GGT5 -8486 -10447



NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
metric value
setSize 5
pMANOVA 0.043
p.adjustMANOVA 0.144
s.dist 0.673
s.dex_eos_adj -0.459
s.dex_pod1_adj 0.492
p.dex_eos_adj 0.0754
p.dex_pod1_adj 0.0566



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
NR1H3 -10873 9411
RXRA -10819 4525
RXRB -9176 4502
NR1H2 -2603 2540

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
NR1H2 -2603 2540
NR1H3 -10873 9411
PLIN1 5069 2993
RXRA -10819 4525
RXRB -9176 4502



Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
metric value
setSize 5
pMANOVA 0.0321
p.adjustMANOVA 0.118
s.dist 0.667
s.dex_eos_adj -0.0993
s.dex_pod1_adj -0.66
p.dex_eos_adj 0.701
p.dex_pod1_adj 0.0106



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
LRP6 -9417 -9453
KREMEN2 -4038 -1531

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
KREMEN1 3593 -8272
KREMEN2 -4038 -1531
LRP5 67 -10205
LRP6 -9417 -9453
WNT4 398 -7401



RUNX3 regulates BCL2L11 (BIM) transcription
RUNX3 regulates BCL2L11 (BIM) transcription
metric value
setSize 5
pMANOVA 0.0304
p.adjustMANOVA 0.115
s.dist 0.655
s.dex_eos_adj 0.472
s.dex_pod1_adj 0.454
p.dex_eos_adj 0.0678
p.dex_pod1_adj 0.0786



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
FOXO3 9702 8591
BCL2L11 8276 7918
RUNX3 7072 1160

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
BCL2L11 8276 7918
FOXO3 9702 8591
RUNX3 7072 1160
SMAD3 -1218 9691
SMAD4 -3085 -5397



Phenylalanine metabolism
Phenylalanine metabolism
metric value
setSize 5
pMANOVA 0.0514
p.adjustMANOVA 0.163
s.dist 0.653
s.dex_eos_adj -0.512
s.dex_pod1_adj 0.406
p.dex_eos_adj 0.0474
p.dex_pod1_adj 0.116



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
IL4I1 -10958 8205
KYAT1 -9136 7486
QDPR -4527 7653

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
ASRGL1 -11384 -1462
IL4I1 -10958 8205
KYAT1 -9136 7486
PCBD1 4817 -2488
QDPR -4527 7653



Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
metric value
setSize 13
pMANOVA 0.000484
p.adjustMANOVA 0.00417
s.dist 0.65
s.dex_eos_adj 0.47
s.dex_pod1_adj -0.449
p.dex_eos_adj 0.00332
p.dex_pod1_adj 0.00505



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
YWHAZ 8033 -10072
CCNB1 4754 -10081
YWHAE 5096 -9027
WEE1 9378 -3451
CDK1 2568 -10819
CHEK1 2945 -8586
YWHAQ 8375 -2302
YWHAG 8247 -1675

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CCNB1 4754 -10081
CDC25C 6275 1336
CDK1 2568 -10819
CHEK1 2945 -8586
CHEK2 -11066 -6206
SFN 2231 3096
WEE1 9378 -3451
YWHAB -96 -9715
YWHAE 5096 -9027
YWHAG 8247 -1675
YWHAH 7010 595
YWHAQ 8375 -2302
YWHAZ 8033 -10072



Formation of the active cofactor, UDP-glucuronate
Formation of the active cofactor, UDP-glucuronate
metric value
setSize 5
pMANOVA 0.0548
p.adjustMANOVA 0.169
s.dist 0.647
s.dex_eos_adj 0.476
s.dex_pod1_adj -0.438
p.dex_eos_adj 0.0653
p.dex_pod1_adj 0.0901



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
UGP2 8164 -10757
UGDH 8201 -6817
SLC35D1 5217 -5242

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
SLC35D1 5217 -5242
SLC35D2 9077 6107
UGDH 8201 -6817
UGP2 8164 -10757
UXS1 -9678 -8428



SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
metric value
setSize 7
pMANOVA 0.0112
p.adjustMANOVA 0.0518
s.dist 0.646
s.dex_eos_adj -0.0786
s.dex_pod1_adj -0.641
p.dex_eos_adj 0.719
p.dex_pod1_adj 0.00332



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP9 -6038 -9449
XIAP -2635 -10021

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP3 352 -10505
CASP7 3761 -7270
CASP9 -6038 -9449
CYCS 7210 -5754
DIABLO -4814 1688
XIAP -2635 -10021



SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
metric value
setSize 7
pMANOVA 0.0112
p.adjustMANOVA 0.0518
s.dist 0.646
s.dex_eos_adj -0.0786
s.dex_pod1_adj -0.641
p.dex_eos_adj 0.719
p.dex_pod1_adj 0.00332



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP9 -6038 -9449
XIAP -2635 -10021

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP3 352 -10505
CASP7 3761 -7270
CASP9 -6038 -9449
CYCS 7210 -5754
DIABLO -4814 1688
XIAP -2635 -10021



SMAC, XIAP-regulated apoptotic response
SMAC, XIAP-regulated apoptotic response
metric value
setSize 7
pMANOVA 0.0112
p.adjustMANOVA 0.0518
s.dist 0.646
s.dex_eos_adj -0.0786
s.dex_pod1_adj -0.641
p.dex_eos_adj 0.719
p.dex_pod1_adj 0.00332



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP9 -6038 -9449
XIAP -2635 -10021

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
APAF1 -9464 -8894
CASP3 352 -10505
CASP7 3761 -7270
CASP9 -6038 -9449
CYCS 7210 -5754
DIABLO -4814 1688
XIAP -2635 -10021



Regulation of NPAS4 gene expression
Regulation of NPAS4 gene expression
metric value
setSize 11
pMANOVA 0.000591
p.adjustMANOVA 0.00492
s.dist 0.644
s.dex_eos_adj -0.41
s.dex_pod1_adj -0.497
p.dex_eos_adj 0.0184
p.dex_pod1_adj 0.00434



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
TNRC6C -9324 -8729
NR3C1 -7299 -7536
SRF -6838 -7181
MOV10 -10998 -3249
AGO3 -4045 -6126
AGO4 -2750 -8313
TNRC6A -7039 -3162
TNRC6B -3929 -4776

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
AGO1 -11294 98
AGO2 4616 -2829
AGO3 -4045 -6126
AGO4 -2750 -8313
MOV10 -10998 -3249
NR3C1 -7299 -7536
REST 2082 -10333
SRF -6838 -7181
TNRC6A -7039 -3162
TNRC6B -3929 -4776
TNRC6C -9324 -8729



Regulation of TP53 Activity through Association with Co-factors
Regulation of TP53 Activity through Association with Co-factors
metric value
setSize 11
pMANOVA 0.0017
p.adjustMANOVA 0.012
s.dist 0.637
s.dex_eos_adj -0.233
s.dex_pod1_adj 0.593
p.dex_eos_adj 0.181
p.dex_pod1_adj 0.000657



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ZNF385A -10495 9831
TP53 -11093 8996
AKT1 -5455 9837
BANP -4265 8301
AKT2 -3623 8350
PPP1R13B -4117 7259
AKT3 -5014 5645
TP73 -4349 6451
PPP1R13L -1122 6339

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
AKT1 -5455 9837
AKT2 -3623 8350
AKT3 -5014 5645
BANP -4265 8301
PHF20 4182 -6384
PPP1R13B -4117 7259
PPP1R13L -1122 6339
TP53 -11093 8996
TP53BP2 9164 -183
TP73 -4349 6451
ZNF385A -10495 9831



Type I hemidesmosome assembly
Type I hemidesmosome assembly
metric value
setSize 8
pMANOVA 0.00552
p.adjustMANOVA 0.0306
s.dist 0.637
s.dex_eos_adj -0.276
s.dex_pod1_adj -0.574
p.dex_eos_adj 0.177
p.dex_pod1_adj 0.00494



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
KRT5 -11301 -10969
LAMB3 -10113 -10885
ITGB4 -9805 -5160
DST -11340 -4241
ITGA6 -1772 -9641

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CD151 4326 -1123
COL17A1 3030 -9179
DST -11340 -4241
ITGA6 -1772 -9641
ITGB4 -9805 -5160
KRT5 -11301 -10969
LAMB3 -10113 -10885
PLEC 7030 -524



Condensation of Prometaphase Chromosomes
Condensation of Prometaphase Chromosomes
metric value
setSize 11
pMANOVA 0.00193
p.adjustMANOVA 0.0133
s.dist 0.635
s.dex_eos_adj 0.288
s.dex_pod1_adj -0.565
p.dex_eos_adj 0.0978
p.dex_pod1_adj 0.00117



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
NCAPH 7835 -9618
NCAPG 7342 -9675
CCNB1 4754 -10081
CCNB2 5287 -8987
CSNK2A1 5649 -7846
CDK1 2568 -10819
CSNK2A2 6945 -3446

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CCNB1 4754 -10081
CCNB2 5287 -8987
CDK1 2568 -10819
CSNK2A1 5649 -7846
CSNK2A2 6945 -3446
CSNK2B 1300 4592
NCAPD2 -8702 -8731
NCAPG 7342 -9675
NCAPH 7835 -9618
SMC2 -5967 795
SMC4 -2666 -6301



OAS antiviral response
OAS antiviral response
metric value
setSize 8
pMANOVA 0.0056
p.adjustMANOVA 0.0309
s.dist 0.633
s.dex_eos_adj -0.329
s.dex_pod1_adj -0.541
p.dex_eos_adj 0.107
p.dex_pod1_adj 0.00806



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
RNASEL -8107 -10467
OAS1 -7069 -10439
OASL -7454 -9615
OAS2 -5202 -10580
OAS3 -3270 -9287

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
ABCE1 2664 673
FLNA -8545 1183
OAS1 -7069 -10439
OAS2 -5202 -10580
OAS3 -3270 -9287
OASL -7454 -9615
PDE12 2530 -410
RNASEL -8107 -10467



MET activates PI3K/AKT signaling
MET activates PI3K/AKT signaling
metric value
setSize 5
pMANOVA 0.0629
p.adjustMANOVA 0.184
s.dist 0.631
s.dex_eos_adj 0.435
s.dex_pod1_adj -0.458
p.dex_eos_adj 0.0922
p.dex_pod1_adj 0.0764



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
HGF 8508 -10432
PIK3R1 4052 -5572
GRB2 1934 -4460

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All member genes
dex_eos_adj dex_pod1_adj
GAB1 8401 3114
GRB2 1934 -4460
HGF 8508 -10432
PIK3CA -4086 -8841
PIK3R1 4052 -5572



Maturation of protein 3a_9683673
Maturation of protein 3a_9683673
metric value
setSize 9
pMANOVA 0.00388
p.adjustMANOVA 0.0236
s.dist 0.628
s.dex_eos_adj -0.142
s.dex_pod1_adj -0.612
p.dex_eos_adj 0.461
p.dex_pod1_adj 0.00147



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ST3GAL4 -10368 -9882
ST3GAL2 -10373 -9205
ST6GAL1 -9053 -5257
GALNT1 -2912 -10509
ST6GALNAC4 -10786 -2134

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
GALNT1 -2912 -10509
ST3GAL1 2241 -5649
ST3GAL2 -10373 -9205
ST3GAL3 6895 -2674
ST3GAL4 -10368 -9882
ST6GAL1 -9053 -5257
ST6GALNAC2 3914 -6915
ST6GALNAC3 9468 -9593
ST6GALNAC4 -10786 -2134



Maturation of protein 3a_9694719
Maturation of protein 3a_9694719
metric value
setSize 9
pMANOVA 0.00388
p.adjustMANOVA 0.0236
s.dist 0.628
s.dex_eos_adj -0.142
s.dex_pod1_adj -0.612
p.dex_eos_adj 0.461
p.dex_pod1_adj 0.00147



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ST3GAL4 -10368 -9882
ST3GAL2 -10373 -9205
ST6GAL1 -9053 -5257
GALNT1 -2912 -10509
ST6GALNAC4 -10786 -2134

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
GALNT1 -2912 -10509
ST3GAL1 2241 -5649
ST3GAL2 -10373 -9205
ST3GAL3 6895 -2674
ST3GAL4 -10368 -9882
ST6GAL1 -9053 -5257
ST6GALNAC2 3914 -6915
ST6GALNAC3 9468 -9593
ST6GALNAC4 -10786 -2134



RHOT1 GTPase cycle
RHOT1 GTPase cycle
metric value
setSize 5
pMANOVA 0.0637
p.adjustMANOVA 0.185
s.dist 0.626
s.dex_eos_adj 0.548
s.dex_pod1_adj -0.302
p.dex_eos_adj 0.0339
p.dex_pod1_adj 0.242



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
RAP1GDS1 9411 -9104
RHOT1 8080 -7668
TRAK2 9330 -3292

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All member genes
dex_eos_adj dex_pod1_adj
MYO19 3613 2118
RAP1GDS1 9411 -9104
RHOT1 8080 -7668
TRAK1 -5664 -43
TRAK2 9330 -3292



Scavenging of heme from plasma
Scavenging of heme from plasma
metric value
setSize 69
pMANOVA 7.45e-17
p.adjustMANOVA 6.82e-15
s.dist 0.623
s.dex_eos_adj 0.458
s.dex_pod1_adj -0.423
p.dex_eos_adj 4.79e-11
p.dex_pod1_adj 1.27e-09



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
IGLV4-69 8686 -8712
JCHAIN 7656 -9272
IGKV4-1 6840 -10340
IGHV4-34 6901 -9680
IGHV3-33 6711 -9418
IGKV3-15 6126 -10116
IGHV2-5 9003 -6474
IGHV3-23 7433 -7815
IGKC 7587 -7654
IGHV3-13 8459 -6854
IGHV1-2 6083 -9150
IGHV4-59 5844 -9463
IGKV1-5 5963 -8758
IGKV1D-39 5405 -9149
IGKV1-17 5389 -8856
IGKV3-20 4567 -9833
IGKV1-16 7441 -5982
IGHV1-69 5887 -7372
IGLC2 5350 -7832
IGLV1-51 7630 -5251

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
APOL1 -11019 -10156
CD163 9727 8912
HBA1 -3221 -4920
HBB -1352 -5830
HP -3785 -10931
HPX -8340 8838
IGHA1 8575 -3323
IGHA2 7750 -3111
IGHV1-2 6083 -9150
IGHV1-46 4687 -5771
IGHV1-69 5887 -7372
IGHV2-5 9003 -6474
IGHV2-70 3852 -8401
IGHV3-11 5149 -234
IGHV3-13 8459 -6854
IGHV3-23 7433 -7815
IGHV3-30 1359 -621
IGHV3-33 6711 -9418
IGHV3-48 7066 -2583
IGHV3-53 6878 358
IGHV3-7 7594 -4879
IGHV4-34 6901 -9680
IGHV4-39 102 -10332
IGHV4-59 5844 -9463
IGKC 7587 -7654
IGKV1-12 5882 505
IGKV1-16 7441 -5982
IGKV1-17 5389 -8856
IGKV1-33 8184 -486
IGKV1-5 5963 -8758
IGKV1D-39 5405 -9149
IGKV2-28 4578 -7532
IGKV2-29 4275 2943
IGKV2-30 8396 7524
IGKV2D-28 2970 -4073
IGKV3-11 7388 -2015
IGKV3-15 6126 -10116
IGKV3-20 4567 -9833
IGKV3D-20 824 -5777
IGKV4-1 6840 -10340
IGLC1 7618 976
IGLC2 5350 -7832
IGLC3 6141 -1471
IGLV1-36 -423 -5027
IGLV1-40 5163 -5419
IGLV1-44 8795 724
IGLV1-47 -2018 -8743
IGLV1-51 7630 -5251
IGLV10-54 8463 9118
IGLV2-11 5654 -1456
IGLV2-14 -1478 -9341
IGLV2-18 8563 1519
IGLV2-23 8129 -630
IGLV2-8 4073 -4267
IGLV3-1 -5393 -7792
IGLV3-12 -10248 -5668
IGLV3-19 6074 -3191
IGLV3-21 -2550 -9908
IGLV3-25 1194 -10417
IGLV3-27 4654 -7597
IGLV4-60 4183 -7330
IGLV4-69 8686 -8712
IGLV5-45 -4448 -10215
IGLV6-57 1642 -7393
IGLV7-43 5044 -6845
IGLV7-46 4098 -185
IGLV8-61 3738 -1768
JCHAIN 7656 -9272
LRP1 -3939 -2753



APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
metric value
setSize 7
pMANOVA 0.0224
p.adjustMANOVA 0.0906
s.dist 0.62
s.dex_eos_adj -0.552
s.dex_pod1_adj 0.282
p.dex_eos_adj 0.0114
p.dex_pod1_adj 0.197



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
OGG1 -7172 9407
PNKP -9141 5824
LIG3 -8669 5897
XRCC1 -9451 3570
NEIL1 -1532 7250

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
LIG3 -8669 5897
NEIL1 -1532 7250
NEIL2 206 -4103
OGG1 -7172 9407
PNKP -9141 5824
POLB -10882 -9860
XRCC1 -9451 3570



Interleukin-6 signaling
Interleukin-6 signaling
metric value
setSize 10
pMANOVA 0.00245
p.adjustMANOVA 0.0162
s.dist 0.619
s.dex_eos_adj -0.164
s.dex_pod1_adj -0.596
p.dex_eos_adj 0.369
p.dex_pod1_adj 0.00109



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
SOCS3 -10608 -10362
STAT1 -9278 -10868
IL6R -11123 -5874
CBL -6920 -6557

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CBL -6920 -6557
IL6R -11123 -5874
IL6ST 9179 -10260
JAK1 930 -9127
JAK2 955 -4086
PTPN11 3586 -8658
SOCS3 -10608 -10362
STAT1 -9278 -10868
STAT3 5538 -9846
TYK2 -7891 8603



FCGR activation
FCGR activation
metric value
setSize 75
pMANOVA 7.51e-18
p.adjustMANOVA 8.48e-16
s.dist 0.616
s.dex_eos_adj 0.409
s.dex_pod1_adj -0.46
p.dex_eos_adj 8.99e-10
p.dex_pod1_adj 5.45e-12



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
FGR 9133 -10283
FYN 9265 -8469
IGLV4-69 8686 -8712
IGKV4-1 6840 -10340
IGHV4-34 6901 -9680
IGHV3-33 6711 -9418
IGKV3-15 6126 -10116
YES1 7018 -8777
IGHV2-5 9003 -6474
IGHV3-23 7433 -7815
IGKC 7587 -7654
IGHV3-13 8459 -6854
IGHV1-2 6083 -9150
IGHV4-59 5844 -9463
IGKV1-5 5963 -8758
IGKV1D-39 5405 -9149
IGKV1-17 5389 -8856
IGKV3-20 4567 -9833
IGKV1-16 7441 -5982
IGHV1-69 5887 -7372

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
CD247 -8148 3113
CD3G 8335 -4646
FCGR1A -8282 -10806
FCGR2A -9460 -1582
FCGR3A -2637 -8545
FGR 9133 -10283
FYN 9265 -8469
HCK -8218 -9995
IGHG1 -4538 -10672
IGHG2 4802 1520
IGHG3 1873 -8641
IGHG4 -7 -9788
IGHV1-2 6083 -9150
IGHV1-46 4687 -5771
IGHV1-69 5887 -7372
IGHV2-5 9003 -6474
IGHV2-70 3852 -8401
IGHV3-11 5149 -234
IGHV3-13 8459 -6854
IGHV3-23 7433 -7815
IGHV3-30 1359 -621
IGHV3-33 6711 -9418
IGHV3-48 7066 -2583
IGHV3-53 6878 358
IGHV3-7 7594 -4879
IGHV4-34 6901 -9680
IGHV4-39 102 -10332
IGHV4-59 5844 -9463
IGKC 7587 -7654
IGKV1-12 5882 505
IGKV1-16 7441 -5982
IGKV1-17 5389 -8856
IGKV1-33 8184 -486
IGKV1-5 5963 -8758
IGKV1D-39 5405 -9149
IGKV2-28 4578 -7532
IGKV2-29 4275 2943
IGKV2-30 8396 7524
IGKV2D-28 2970 -4073
IGKV3-11 7388 -2015
IGKV3-15 6126 -10116
IGKV3-20 4567 -9833
IGKV3D-20 824 -5777
IGKV4-1 6840 -10340
IGLC1 7618 976
IGLC2 5350 -7832
IGLC3 6141 -1471
IGLV1-36 -423 -5027
IGLV1-40 5163 -5419
IGLV1-44 8795 724
IGLV1-47 -2018 -8743
IGLV1-51 7630 -5251
IGLV10-54 8463 9118
IGLV2-11 5654 -1456
IGLV2-14 -1478 -9341
IGLV2-18 8563 1519
IGLV2-23 8129 -630
IGLV2-8 4073 -4267
IGLV3-1 -5393 -7792
IGLV3-12 -10248 -5668
IGLV3-19 6074 -3191
IGLV3-21 -2550 -9908
IGLV3-25 1194 -10417
IGLV3-27 4654 -7597
IGLV4-60 4183 -7330
IGLV4-69 8686 -8712
IGLV5-45 -4448 -10215
IGLV6-57 1642 -7393
IGLV7-43 5044 -6845
IGLV7-46 4098 -185
IGLV8-61 3738 -1768
LYN -6375 -10553
SRC -11108 1802
SYK 5772 5066
YES1 7018 -8777



Biosynthesis of Lipoxins (LX)
Biosynthesis of Lipoxins (LX)
metric value
setSize 6
pMANOVA 0.0371
p.adjustMANOVA 0.13
s.dist 0.615
s.dex_eos_adj 0.596
s.dex_pod1_adj -0.149
p.dex_eos_adj 0.0114
p.dex_pod1_adj 0.527



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
ALOX5AP 9334 -9325
HPGD 9520 -8907
PTGR1 3682 -10855

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
ALOX12 8255 5329
ALOX5 7418 2959
ALOX5AP 9334 -9325
HPGD 9520 -8907
LTC4S -5400 8929
PTGR1 3682 -10855



Propionyl-CoA catabolism
Propionyl-CoA catabolism
metric value
setSize 5
pMANOVA 0.0633
p.adjustMANOVA 0.184
s.dist 0.615
s.dex_eos_adj -0.602
s.dex_pod1_adj 0.124
p.dex_eos_adj 0.0198
p.dex_pod1_adj 0.63



Top 20 genes
Gene dex_eos_adj dex_pod1_adj
PCCA -9521 6994
MCEE -9984 4205
PCCB -2874 8800

Click HERE to show all gene set members

All member genes
dex_eos_adj dex_pod1_adj
MCEE -9984 4205
MMAA -8907 -5548
MMUT -4653 -9911
PCCA -9521 6994
PCCB -2874 8800



Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}
## Network charts only generated in one-dimensional analysis.

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] gtools_3.9.5                RhpcBLASctl_0.23-42        
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] eulerr_7.1.0                ggplot2_4.0.3              
##  [7] kableExtra_1.4.0            MASS_7.3-65                
##  [9] mitch_1.22.1                DESeq2_1.50.2              
## [11] SummarizedExperiment_1.40.0 Biobase_2.70.0             
## [13] MatrixGenerics_1.22.0       matrixStats_1.5.0          
## [15] GenomicRanges_1.62.1        Seqinfo_1.0.0              
## [17] IRanges_2.44.0              S4Vectors_0.48.1           
## [19] BiocGenerics_0.56.0         generics_0.1.4             
## [21] dplyr_1.2.1                 WGCNA_1.74                 
## [23] fastcluster_1.3.0           dynamicTreeCut_1.63-1      
## [25] reshape2_1.4.5              gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] Hmisc_5.2-5           labeling_0.4.3        polyclip_1.10-7      
##  [37] abind_1.4-8           compiler_4.5.2        withr_3.0.2          
##  [40] doParallel_1.0.17     htmlTable_2.5.0       S7_0.2.2             
##  [43] backports_1.5.1       BiocParallel_1.44.0   ggstats_0.13.0       
##  [46] DelayedArray_0.36.1   caTools_1.18.3        tools_4.5.2          
##  [49] foreign_0.8-90        otel_0.2.0            beeswarm_0.4.0       
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.4     xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report