Mitch Report

date generated: 2026-06-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	crp_eos_adj	dex_eos_adj
5_8S_rRNA	-2.4785778	2.3372330
A1BG	-1.7542512	-0.1044447
A1BG-AS1	-1.0734376	0.3112347
A1CF	0.5521423	0.9717804
A2M	1.6603822	2.6139639
A2M-AS1	1.3818491	2.4240591

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	21999
duplicated_genes_present	0
num_profile_genes_in_sets	8829
num_profile_genes_not_in_sets	13170
profile_pearson_correl	-0.39489
profile_spearman_correl	-0.34705

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1188
num_genesets_included	1537

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 627

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_eos_adj	s.dex_eos_adj	p.crp_eos_adj	p.dex_eos_adj
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	6.31e-10	8.64e-09	1.000	-0.727	0.687000	4.07e-08	2.15e-07
Formation of the ureteric bud	5	4.30e-03	1.68e-02	0.959	-0.492	0.824000	5.69e-02	1.42e-03
Modulation by Mtb of host immune system	7	4.97e-04	2.48e-03	0.955	-0.826	0.478000	1.53e-04	2.84e-02
Mitochondrial RNA degradation	25	8.44e-11	1.35e-09	0.911	-0.684	0.602000	3.17e-09	1.91e-07
Defective binding of VWF variant to GPIb:IX:V	7	1.46e-03	6.57e-03	0.906	-0.544	0.724000	1.27e-02	9.04e-04
Enhanced binding of GP1BA variant to VWF multimer:collagen	7	1.46e-03	6.57e-03	0.906	-0.544	0.724000	1.27e-02	9.04e-04
Formation of ATP by chemiosmotic coupling	20	3.29e-10	4.82e-09	0.898	-0.853	0.282000	3.91e-11	2.90e-02
Protein repair	6	4.41e-03	1.72e-02	0.880	-0.477	0.740000	4.30e-02	1.70e-03
MECP2 regulates transcription of neuronal ligands	5	1.21e-02	3.94e-02	0.869	0.468	-0.733000	7.02e-02	4.53e-03
tRNA processing in the mitochondrion	24	3.66e-09	4.36e-08	0.851	-0.636	0.566000	6.94e-08	1.57e-06
RNA Polymerase I Promoter Opening	17	1.03e-06	8.36e-06	0.844	-0.676	0.506000	1.39e-06	3.01e-04
Peptide chain elongation	88	1.41e-47	1.60e-45	0.843	-0.843	-0.014000	1.15e-42	8.20e-01
Formation of a pool of free 40S subunits	100	1.17e-52	1.88e-50	0.843	-0.842	0.015900	3.11e-48	7.83e-01
Eukaryotic Translation Elongation	93	1.90e-49	2.45e-47	0.835	-0.834	-0.017600	3.70e-44	7.69e-01
Tandem pore domain potassium channels	5	1.83e-02	5.46e-02	0.831	0.463	-0.690000	7.29e-02	7.50e-03
Viral mRNA Translation	88	9.47e-46	9.63e-44	0.831	-0.831	0.000498	1.49e-41	9.94e-01
L13a-mediated translational silencing of Ceruloplasmin expression	110	4.15e-54	8.03e-52	0.828	-0.826	0.054000	6.07e-51	3.28e-01
SUMO is conjugated to E1 (UBA2:SAE1)	5	1.46e-02	4.58e-02	0.824	-0.743	0.356000	3.99e-03	1.68e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	111	4.91e-54	8.63e-52	0.824	-0.822	0.053200	7.36e-51	3.33e-01
Formation of xylulose-5-phosphate	5	4.22e-04	2.15e-03	0.823	-0.602	-0.560000	1.97e-02	3.00e-02
SARS-CoV-1 modulates host translation machinery	36	1.55e-18	5.53e-17	0.819	-0.819	0.005160	1.72e-17	9.57e-01
Cap-dependent Translation Initiation	118	5.82e-57	1.25e-54	0.818	-0.817	0.045300	2.87e-53	3.95e-01
Eukaryotic Translation Initiation	118	5.82e-57	1.25e-54	0.818	-0.817	0.045300	2.87e-53	3.95e-01
Formation of the ternary complex, and subsequently, the 43S complex	51	2.55e-24	1.07e-22	0.816	-0.813	0.072700	9.14e-24	3.69e-01
Interleukin-21 signaling	9	1.24e-03	5.67e-03	0.814	0.628	-0.517000	1.11e-03	7.18e-03
Mitochondrial translation initiation	90	2.71e-41	2.02e-39	0.812	-0.807	0.090900	4.03e-40	1.36e-01
G2/M DNA replication checkpoint	5	2.54e-02	7.21e-02	0.812	-0.551	0.596000	3.28e-02	2.10e-02
rRNA processing in the mitochondrion	24	1.03e-08	1.17e-07	0.811	-0.680	0.442000	7.81e-09	1.80e-04
SRP-dependent cotranslational protein targeting to membrane	111	1.20e-50	1.66e-48	0.810	-0.805	0.088100	6.91e-49	1.09e-01
Eukaryotic Translation Termination	92	5.57e-46	5.98e-44	0.810	-0.810	-0.013800	2.94e-41	8.19e-01
Post-transcriptional silencing by small RNAs	7	3.89e-03	1.56e-02	0.810	0.712	-0.386000	1.11e-03	7.72e-02
Packaging Of Telomere Ends	18	8.15e-07	6.79e-06	0.810	-0.698	0.410000	2.90e-07	2.61e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	4.00e-26	1.84e-24	0.806	-0.796	0.122000	3.26e-26	1.04e-01
Selenocysteine synthesis	92	1.16e-45	1.12e-43	0.805	-0.805	-0.020500	9.69e-41	7.34e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	8.76e-45	8.06e-43	0.802	-0.802	0.020200	2.37e-41	7.35e-01
Translation initiation complex formation	58	1.67e-25	7.49e-24	0.802	-0.793	0.121000	1.32e-25	1.10e-01
Ribosomal scanning and start codon recognition	58	2.22e-25	9.74e-24	0.801	-0.791	0.123000	1.66e-25	1.06e-01
Mitochondrial translation elongation	90	5.95e-40	3.59e-38	0.799	-0.794	0.089900	7.27e-39	1.40e-01
G2 Phase	5	2.89e-02	7.98e-02	0.794	-0.510	0.610000	4.85e-02	1.82e-02
Mitochondrial translation termination	90	6.55e-39	3.83e-37	0.789	-0.783	0.090000	6.58e-38	1.40e-01
Phosphate bond hydrolysis by NUDT proteins	7	2.71e-03	1.13e-02	0.782	-0.749	0.223000	5.94e-04	3.06e-01
Mitochondrial translation	96	7.60e-41	5.43e-39	0.781	-0.776	0.083800	1.31e-39	1.56e-01
Regulation of CDH11 mRNA translation by microRNAs	8	3.91e-03	1.56e-02	0.779	0.630	-0.458000	2.03e-03	2.49e-02
Regulation of NPAS4 mRNA translation	8	3.91e-03	1.56e-02	0.779	0.630	-0.458000	2.03e-03	2.49e-02
Replacement of protamines by nucleosomes in the male pronucleus	13	1.52e-04	8.63e-04	0.778	-0.518	0.580000	1.21e-03	2.91e-04
Complex III assembly	23	4.08e-10	5.84e-09	0.765	-0.762	0.063200	2.46e-10	6.00e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	2.47e-43	2.07e-41	0.764	-0.764	0.016500	5.87e-40	7.76e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	4.96e-04	2.48e-03	0.764	0.338	0.685000	1.52e-01	3.68e-03
Arachidonate production from DAG	5	1.45e-02	4.55e-02	0.754	-0.741	0.141000	4.10e-03	5.86e-01
CD163 mediating an anti-inflammatory response	9	1.30e-04	7.46e-04	0.753	0.032	0.752000	8.68e-01	9.37e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_eos_adj	s.dex_eos_adj	p.crp_eos_adj	p.dex_eos_adj
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	6.31e-10	8.64e-09	1.00000	-7.27e-01	6.87e-01	4.07e-08	2.15e-07
Formation of the ureteric bud	5	4.30e-03	1.68e-02	0.95900	-4.92e-01	8.24e-01	5.69e-02	1.42e-03
Modulation by Mtb of host immune system	7	4.97e-04	2.48e-03	0.95500	-8.26e-01	4.78e-01	1.53e-04	2.84e-02
Mitochondrial RNA degradation	25	8.44e-11	1.35e-09	0.91100	-6.84e-01	6.02e-01	3.17e-09	1.91e-07
Defective binding of VWF variant to GPIb:IX:V	7	1.46e-03	6.57e-03	0.90600	-5.44e-01	7.24e-01	1.27e-02	9.04e-04
Enhanced binding of GP1BA variant to VWF multimer:collagen	7	1.46e-03	6.57e-03	0.90600	-5.44e-01	7.24e-01	1.27e-02	9.04e-04
Formation of ATP by chemiosmotic coupling	20	3.29e-10	4.82e-09	0.89800	-8.53e-01	2.82e-01	3.91e-11	2.90e-02
Protein repair	6	4.41e-03	1.72e-02	0.88000	-4.77e-01	7.40e-01	4.30e-02	1.70e-03
MECP2 regulates transcription of neuronal ligands	5	1.21e-02	3.94e-02	0.86900	4.68e-01	-7.33e-01	7.02e-02	4.53e-03
tRNA processing in the mitochondrion	24	3.66e-09	4.36e-08	0.85100	-6.36e-01	5.66e-01	6.94e-08	1.57e-06
RNA Polymerase I Promoter Opening	17	1.03e-06	8.36e-06	0.84400	-6.76e-01	5.06e-01	1.39e-06	3.01e-04
Peptide chain elongation	88	1.41e-47	1.60e-45	0.84300	-8.43e-01	-1.40e-02	1.15e-42	8.20e-01
Formation of a pool of free 40S subunits	100	1.17e-52	1.88e-50	0.84300	-8.42e-01	1.59e-02	3.11e-48	7.83e-01
Eukaryotic Translation Elongation	93	1.90e-49	2.45e-47	0.83500	-8.34e-01	-1.76e-02	3.70e-44	7.69e-01
Tandem pore domain potassium channels	5	1.83e-02	5.46e-02	0.83100	4.63e-01	-6.90e-01	7.29e-02	7.50e-03
Viral mRNA Translation	88	9.47e-46	9.63e-44	0.83100	-8.31e-01	4.98e-04	1.49e-41	9.94e-01
L13a-mediated translational silencing of Ceruloplasmin expression	110	4.15e-54	8.03e-52	0.82800	-8.26e-01	5.40e-02	6.07e-51	3.28e-01
SUMO is conjugated to E1 (UBA2:SAE1)	5	1.46e-02	4.58e-02	0.82400	-7.43e-01	3.56e-01	3.99e-03	1.68e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	111	4.91e-54	8.63e-52	0.82400	-8.22e-01	5.32e-02	7.36e-51	3.33e-01
Formation of xylulose-5-phosphate	5	4.22e-04	2.15e-03	0.82300	-6.02e-01	-5.60e-01	1.97e-02	3.00e-02
SARS-CoV-1 modulates host translation machinery	36	1.55e-18	5.53e-17	0.81900	-8.19e-01	5.16e-03	1.72e-17	9.57e-01
Cap-dependent Translation Initiation	118	5.82e-57	1.25e-54	0.81800	-8.17e-01	4.53e-02	2.87e-53	3.95e-01
Eukaryotic Translation Initiation	118	5.82e-57	1.25e-54	0.81800	-8.17e-01	4.53e-02	2.87e-53	3.95e-01
Formation of the ternary complex, and subsequently, the 43S complex	51	2.55e-24	1.07e-22	0.81600	-8.13e-01	7.27e-02	9.14e-24	3.69e-01
Interleukin-21 signaling	9	1.24e-03	5.67e-03	0.81400	6.28e-01	-5.17e-01	1.11e-03	7.18e-03
Mitochondrial translation initiation	90	2.71e-41	2.02e-39	0.81200	-8.07e-01	9.09e-02	4.03e-40	1.36e-01
G2/M DNA replication checkpoint	5	2.54e-02	7.21e-02	0.81200	-5.51e-01	5.96e-01	3.28e-02	2.10e-02
rRNA processing in the mitochondrion	24	1.03e-08	1.17e-07	0.81100	-6.80e-01	4.42e-01	7.81e-09	1.80e-04
SRP-dependent cotranslational protein targeting to membrane	111	1.20e-50	1.66e-48	0.81000	-8.05e-01	8.81e-02	6.91e-49	1.09e-01
Eukaryotic Translation Termination	92	5.57e-46	5.98e-44	0.81000	-8.10e-01	-1.38e-02	2.94e-41	8.19e-01
Post-transcriptional silencing by small RNAs	7	3.89e-03	1.56e-02	0.81000	7.12e-01	-3.86e-01	1.11e-03	7.72e-02
Packaging Of Telomere Ends	18	8.15e-07	6.79e-06	0.81000	-6.98e-01	4.10e-01	2.90e-07	2.61e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	4.00e-26	1.84e-24	0.80600	-7.96e-01	1.22e-01	3.26e-26	1.04e-01
Selenocysteine synthesis	92	1.16e-45	1.12e-43	0.80500	-8.05e-01	-2.05e-02	9.69e-41	7.34e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	8.76e-45	8.06e-43	0.80200	-8.02e-01	2.02e-02	2.37e-41	7.35e-01
Translation initiation complex formation	58	1.67e-25	7.49e-24	0.80200	-7.93e-01	1.21e-01	1.32e-25	1.10e-01
Ribosomal scanning and start codon recognition	58	2.22e-25	9.74e-24	0.80100	-7.91e-01	1.23e-01	1.66e-25	1.06e-01
Mitochondrial translation elongation	90	5.95e-40	3.59e-38	0.79900	-7.94e-01	8.99e-02	7.27e-39	1.40e-01
G2 Phase	5	2.89e-02	7.98e-02	0.79400	-5.10e-01	6.10e-01	4.85e-02	1.82e-02
Mitochondrial translation termination	90	6.55e-39	3.83e-37	0.78900	-7.83e-01	9.00e-02	6.58e-38	1.40e-01
Phosphate bond hydrolysis by NUDT proteins	7	2.71e-03	1.13e-02	0.78200	-7.49e-01	2.23e-01	5.94e-04	3.06e-01
Mitochondrial translation	96	7.60e-41	5.43e-39	0.78100	-7.76e-01	8.38e-02	1.31e-39	1.56e-01
Regulation of CDH11 mRNA translation by microRNAs	8	3.91e-03	1.56e-02	0.77900	6.30e-01	-4.58e-01	2.03e-03	2.49e-02
Regulation of NPAS4 mRNA translation	8	3.91e-03	1.56e-02	0.77900	6.30e-01	-4.58e-01	2.03e-03	2.49e-02
Replacement of protamines by nucleosomes in the male pronucleus	13	1.52e-04	8.63e-04	0.77800	-5.18e-01	5.80e-01	1.21e-03	2.91e-04
Complex III assembly	23	4.08e-10	5.84e-09	0.76500	-7.62e-01	6.32e-02	2.46e-10	6.00e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	2.47e-43	2.07e-41	0.76400	-7.64e-01	1.65e-02	5.87e-40	7.76e-01
RUNX1 regulates transcription of genes involved in BCR signaling	6	4.96e-04	2.48e-03	0.76400	3.38e-01	6.85e-01	1.52e-01	3.68e-03
Arachidonate production from DAG	5	1.45e-02	4.55e-02	0.75400	-7.41e-01	1.41e-01	4.10e-03	5.86e-01
CD163 mediating an anti-inflammatory response	9	1.30e-04	7.46e-04	0.75300	3.20e-02	7.52e-01	8.68e-01	9.37e-05
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	3.33e-06	2.55e-05	0.74800	-5.82e-01	4.71e-01	6.70e-06	2.64e-04
CD22 mediated BCR regulation	58	4.01e-16	1.25e-14	0.74100	-5.35e-01	5.13e-01	1.78e-12	1.38e-11
Regulation of NPAS4 gene expression	11	1.00e-03	4.69e-03	0.73800	6.08e-01	-4.18e-01	4.76e-04	1.65e-02
Translation	293	1.22e-109	2.36e-106	0.73500	-7.32e-01	7.43e-02	5.08e-104	2.86e-02
SIRT1 negatively regulates rRNA expression	22	9.91e-07	8.11e-06	0.73500	-6.15e-01	4.03e-01	5.86e-07	1.07e-03
Cleavage of the damaged purine	22	3.98e-07	3.47e-06	0.73500	-6.61e-01	3.21e-01	7.86e-08	9.09e-03
Depurination	22	3.98e-07	3.47e-06	0.73500	-6.61e-01	3.21e-01	7.86e-08	9.09e-03
Recognition and association of DNA glycosylase with site containing an affected purine	22	3.98e-07	3.47e-06	0.73500	-6.61e-01	3.21e-01	7.86e-08	9.09e-03
SARS-CoV-2 modulates host translation machinery	49	1.53e-20	5.80e-19	0.73100	-7.30e-01	-2.43e-02	8.67e-19	7.68e-01
MET activates PI3K/AKT signaling	5	2.45e-03	1.04e-02	0.72800	5.88e-01	4.29e-01	2.28e-02	9.65e-02
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	6.12e-03	2.25e-02	0.72700	-6.96e-01	2.10e-01	1.43e-03	3.37e-01
Cristae formation	33	1.57e-11	2.83e-10	0.72400	-7.04e-01	1.67e-01	2.45e-12	9.62e-02
Mitochondrial calcium ion transport	22	7.44e-08	7.33e-07	0.71800	-7.00e-01	1.60e-01	1.31e-08	1.93e-01
TGFBR3 expression	20	8.62e-06	6.22e-05	0.71400	5.80e-01	-4.15e-01	6.96e-06	1.30e-03
Selenoamino acid metabolism	115	7.30e-44	6.41e-42	0.71300	-7.13e-01	2.29e-03	5.91e-40	9.66e-01
Classical antibody-mediated complement activation	69	1.39e-17	4.80e-16	0.70900	-5.41e-01	4.58e-01	7.36e-15	4.83e-11
Synthesis of PI	5	6.07e-02	1.40e-01	0.70800	4.70e-01	-5.30e-01	6.89e-02	4.01e-02
Defects of platelet adhesion to exposed collagen	8	1.16e-02	3.81e-02	0.69900	-4.14e-01	5.63e-01	4.25e-02	5.78e-03
p130Cas linkage to MAPK signaling for integrins	11	1.97e-03	8.52e-03	0.69800	-5.84e-01	3.82e-01	7.95e-04	2.83e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	9.56e-41	6.15e-39	0.68900	-6.89e-01	2.95e-04	3.99e-37	9.96e-01
Nonsense-Mediated Decay (NMD)	114	9.56e-41	6.15e-39	0.68900	-6.89e-01	2.95e-04	3.99e-37	9.96e-01
DNA methylation	18	5.03e-05	3.21e-04	0.68800	-5.74e-01	3.80e-01	2.46e-05	5.29e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.07e-03	4.98e-03	0.68700	-5.05e-01	4.66e-01	1.62e-03	3.65e-03
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	1.50e-02	4.67e-02	0.68600	-6.84e-01	-4.73e-02	8.05e-03	8.55e-01
Propionyl-CoA catabolism	5	5.89e-03	2.19e-02	0.68500	-3.14e-01	-6.09e-01	2.24e-01	1.83e-02
Cation-coupled Chloride cotransporters	6	3.42e-02	9.16e-02	0.68400	5.98e-01	-3.33e-01	1.12e-02	1.58e-01
Scavenging of heme from plasma	70	1.63e-16	5.26e-15	0.68200	-5.10e-01	4.53e-01	1.49e-13	5.67e-11
Processing of SMDT1	15	3.86e-06	2.90e-05	0.68200	-6.80e-01	-4.76e-02	5.06e-06	7.50e-01
rRNA processing	213	5.26e-65	2.54e-62	0.67900	-6.69e-01	1.11e-01	5.14e-64	5.12e-03
Major pathway of rRNA processing in the nucleolus and cytosol	179	2.54e-57	7.02e-55	0.67800	-6.74e-01	6.66e-02	6.87e-55	1.24e-01
Complex I biogenesis	66	2.09e-21	8.09e-20	0.67000	-6.68e-01	5.56e-02	5.80e-21	4.34e-01
Regulation of expression of SLITs and ROBOs	149	9.34e-48	1.13e-45	0.67000	-6.68e-01	4.74e-02	3.08e-45	3.18e-01
rRNA processing in the nucleus and cytosol	189	5.85e-59	1.89e-56	0.67000	-6.66e-01	6.88e-02	1.50e-56	1.03e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	7.00e-03	2.50e-02	0.66600	-4.41e-01	5.00e-01	1.58e-02	6.21e-03
Response to metal ions	6	5.15e-02	1.24e-01	0.66500	-4.43e-01	4.96e-01	6.00e-02	3.54e-02
Creation of C4 and C2 activators	71	4.80e-16	1.45e-14	0.66500	-5.14e-01	4.23e-01	6.87e-14	7.28e-10
Regulation of NFE2L2 gene expression	8	7.13e-03	2.53e-02	0.66200	6.40e-01	-1.72e-01	1.73e-03	3.99e-01
Glucuronidation	9	1.26e-02	4.08e-02	0.66100	-4.73e-01	4.61e-01	1.39e-02	1.66e-02
PINK1-PRKN Mediated Mitophagy	31	1.40e-07	1.32e-06	0.65900	-5.59e-01	3.48e-01	6.99e-08	8.00e-04
Formation of the active cofactor, UDP-glucuronate	5	8.93e-02	1.88e-01	0.65900	-4.58e-01	4.73e-01	7.61e-02	6.68e-02
ATF6 (ATF6-alpha) activates chaperones	12	3.05e-03	1.25e-02	0.65800	-4.52e-01	4.79e-01	6.72e-03	4.09e-03
HDMs demethylate histones	22	3.77e-06	2.85e-05	0.65600	6.15e-01	-2.27e-01	5.84e-07	6.49e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	6.63e-03	2.39e-02	0.65400	-6.39e-01	-1.41e-01	6.73e-03	5.50e-01
Recycling of eIF2:GDP	8	3.10e-03	1.27e-02	0.65400	-6.54e-01	9.54e-03	1.36e-03	9.63e-01
PDH complex synthesizes acetyl-CoA from PYR	5	5.28e-02	1.26e-01	0.65200	-6.25e-01	1.86e-01	1.54e-02	4.72e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	3.11e-02	8.43e-02	0.65000	-6.21e-01	1.95e-01	8.47e-03	4.09e-01
Mitochondrial protein import	63	1.01e-18	3.67e-17	0.64900	-6.45e-01	7.95e-02	8.36e-19	2.75e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	9.01e-11	1.40e-09	0.64600	-6.26e-01	1.60e-01	1.29e-11	8.34e-02
p53-Independent DNA Damage Response	39	9.01e-11	1.40e-09	0.64600	-6.26e-01	1.60e-01	1.29e-11	8.34e-02
p53-Independent G1/S DNA damage checkpoint	39	9.01e-11	1.40e-09	0.64600	-6.26e-01	1.60e-01	1.29e-11	8.34e-02
Inhibition of DNA recombination at telomere	33	2.84e-08	3.00e-07	0.64400	-5.90e-01	2.57e-01	4.38e-09	1.06e-02
Vif-mediated degradation of APOBEC3G	41	5.50e-11	9.32e-10	0.64200	-6.19e-01	1.73e-01	7.06e-12	5.49e-02
Respiratory electron transport	149	9.65e-43	7.46e-41	0.63900	-6.36e-01	5.95e-02	4.25e-41	2.10e-01
Sulfide oxidation to sulfate	5	1.59e-02	4.93e-02	0.63600	-6.07e-01	-1.92e-01	1.88e-02	4.57e-01
Regulation of Expression and Function of Type II Classical Cadherins	25	9.69e-06	6.85e-05	0.63400	5.19e-01	-3.64e-01	6.93e-06	1.63e-03
Regulation of Homotypic Cell-Cell Adhesion	25	9.69e-06	6.85e-05	0.63400	5.19e-01	-3.64e-01	6.93e-06	1.63e-03
Chromatin modifications during the maternal to zygotic transition (MZT)	23	2.99e-05	1.99e-04	0.63300	-3.87e-01	5.01e-01	1.32e-03	3.24e-05
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	3.00e-02	8.20e-02	0.63000	-6.30e-01	-3.14e-02	1.47e-02	9.03e-01
Cleavage of the damaged pyrimidine	27	1.95e-06	1.52e-05	0.63000	-5.62e-01	2.87e-01	4.37e-07	9.95e-03
Depyrimidination	27	1.95e-06	1.52e-05	0.63000	-5.62e-01	2.87e-01	4.37e-07	9.95e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	1.95e-06	1.52e-05	0.63000	-5.62e-01	2.87e-01	4.37e-07	9.95e-03
CDH11 homotypic and heterotypic interactions	6	6.96e-02	1.55e-01	0.62900	4.86e-01	-3.99e-01	3.94e-02	9.06e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	1.63e-09	2.11e-08	0.62800	-6.03e-01	1.76e-01	2.14e-10	6.33e-02
Assembly of the ORC complex at the origin of replication	23	2.36e-05	1.60e-04	0.62800	-5.34e-01	3.30e-01	9.29e-06	6.07e-03
CYP2E1 reactions	6	7.26e-02	1.60e-01	0.62600	4.64e-01	-4.20e-01	4.89e-02	7.51e-02
Maturation of TCA enzymes and regulation of TCA cycle	20	1.57e-06	1.25e-05	0.62500	-6.25e-01	-3.80e-03	1.31e-06	9.77e-01
NADE modulates death signalling	5	1.01e-01	2.04e-01	0.62400	-5.34e-01	3.23e-01	3.88e-02	2.12e-01
Maturation of spike protein 9683686	5	8.83e-02	1.86e-01	0.62300	-5.64e-01	2.63e-01	2.88e-02	3.09e-01
Base-Excision Repair, AP Site Formation	29	7.17e-07	6.02e-06	0.62200	-5.67e-01	2.56e-01	1.24e-07	1.71e-02
Vpu mediated degradation of CD4	39	1.78e-10	2.67e-09	0.62100	-6.11e-01	1.14e-01	3.98e-11	2.17e-01
Regulation of CDH11 Expression and Function	23	3.52e-05	2.33e-04	0.62100	5.15e-01	-3.47e-01	1.89e-05	4.00e-03
Cellular response to mitochondrial stress	9	3.13e-03	1.28e-02	0.62100	-6.20e-01	2.16e-02	1.27e-03	9.11e-01
POLB-Dependent Long Patch Base Excision Repair	8	1.29e-03	5.90e-03	0.62000	-2.66e-01	-5.60e-01	1.93e-01	6.08e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	1.39e-02	4.44e-02	0.61900	-4.27e-01	4.49e-01	1.95e-02	1.39e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	1.38e-10	2.11e-09	0.61700	-6.02e-01	1.32e-01	2.45e-11	1.43e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	5.79e-04	2.86e-03	0.61600	-6.15e-01	-4.08e-02	4.11e-04	8.15e-01
Influenza Viral RNA Transcription and Replication	135	1.62e-40	1.01e-38	0.61400	-6.12e-01	-5.21e-02	1.03e-34	2.96e-01
Folding of actin by CCT/TriC	10	4.14e-03	1.63e-02	0.61400	-5.99e-01	1.31e-01	1.03e-03	4.72e-01
RNA Polymerase I Promoter Escape	45	8.03e-10	1.09e-08	0.60900	-5.53e-01	2.56e-01	1.33e-10	2.99e-03
Hh mutants are degraded by ERAD	42	1.02e-09	1.35e-08	0.60900	-5.74e-01	2.05e-01	1.24e-10	2.18e-02
Defective CFTR causes cystic fibrosis	47	6.95e-11	1.13e-09	0.60800	-5.76e-01	1.95e-01	7.96e-12	2.10e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	5.67e-10	7.83e-09	0.60700	-5.81e-01	1.77e-01	7.09e-11	4.73e-02
Cellular response to starvation	148	2.41e-37	1.29e-35	0.60700	-6.01e-01	7.89e-02	1.06e-36	9.74e-02
Proteasome assembly	50	4.07e-13	9.95e-12	0.60500	-6.00e-01	7.37e-02	2.03e-13	3.67e-01
Apoptosis induced DNA fragmentation	10	1.38e-02	4.43e-02	0.60400	-5.12e-01	3.20e-01	5.02e-03	7.97e-02
Mitochondrial iron-sulfur cluster biogenesis	13	1.20e-04	6.95e-04	0.60400	-5.95e-01	-1.03e-01	2.02e-04	5.21e-01
Hedgehog ligand biogenesis	47	4.99e-10	6.94e-09	0.60300	-5.48e-01	2.51e-01	8.10e-11	2.86e-03
Regulation of Apoptosis	40	2.02e-09	2.55e-08	0.60300	-5.77e-01	1.73e-01	2.62e-10	5.82e-02
Ubiquitin-dependent degradation of Cyclin D	39	1.31e-09	1.71e-08	0.60100	-5.87e-01	1.33e-01	2.25e-10	1.52e-01
NRIF signals cell death from the nucleus	15	1.71e-03	7.53e-03	0.60100	-5.12e-01	3.13e-01	5.90e-04	3.57e-02
Regulation of ornithine decarboxylase (ODC)	38	5.71e-09	6.56e-08	0.60000	-5.76e-01	1.67e-01	7.74e-10	7.45e-02
Regulation of CDH11 gene transcription	5	1.33e-01	2.49e-01	0.60000	3.82e-01	-4.62e-01	1.39e-01	7.38e-02
RNA Polymerase III Chain Elongation	18	1.72e-04	9.59e-04	0.59900	-5.67e-01	1.95e-01	3.13e-05	1.52e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	3.53e-03	1.43e-02	0.59900	3.29e-01	5.01e-01	1.32e-01	2.18e-02
Initial triggering of complement	79	1.05e-14	2.90e-13	0.59800	-4.82e-01	3.55e-01	1.25e-13	5.01e-08
Citric acid cycle (TCA cycle)	34	1.76e-09	2.25e-08	0.59800	-5.97e-01	2.25e-02	1.64e-09	8.20e-01
Translocation of ZAP-70 to Immunological synapse	24	1.25e-06	1.01e-05	0.59700	5.96e-02	-5.94e-01	6.13e-01	4.60e-07
tRNA modification in the mitochondrion	9	6.43e-03	2.33e-02	0.59700	-5.93e-01	6.58e-02	2.06e-03	7.32e-01
Negative regulation of NOTCH4 signaling	44	1.13e-10	1.75e-09	0.59600	-5.83e-01	1.24e-01	2.10e-11	1.56e-01
Biosynthesis of Lipoxins (LX)	6	2.99e-02	8.19e-02	0.59300	-2.13e-02	5.93e-01	9.28e-01	1.19e-02
Hh mutants abrogate ligand secretion	43	2.57e-09	3.18e-08	0.59300	-5.54e-01	2.11e-01	3.26e-10	1.67e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	3.00e-02	8.20e-02	0.59200	-5.72e-01	-1.53e-01	2.67e-02	5.55e-01
PI3K events in ERBB4 signaling	6	7.13e-02	1.58e-01	0.59100	5.38e-01	-2.45e-01	2.24e-02	2.99e-01
Estrogen-stimulated signaling through PRKCZ	6	8.26e-02	1.77e-01	0.59100	-2.97e-01	5.11e-01	2.08e-01	3.02e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	3.77e-13	9.58e-12	0.58900	-5.64e-01	1.71e-01	4.17e-14	2.22e-02
Mitochondrial protein degradation	96	1.98e-22	7.97e-21	0.58900	-5.80e-01	1.01e-01	8.19e-23	8.65e-02
SLBP independent Processing of Histone Pre-mRNAs	10	1.84e-03	7.99e-03	0.58700	-5.83e-01	-6.27e-02	1.41e-03	7.32e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	9.02e-03	3.12e-02	0.58300	-3.30e-01	4.81e-01	4.80e-02	3.89e-03
Metabolism of polyamines	46	3.90e-10	5.66e-09	0.58300	-5.60e-01	1.63e-01	4.99e-11	5.50e-02
Deposition of new CENPA-containing nucleosomes at the centromere	38	1.83e-07	1.69e-06	0.58200	-5.10e-01	2.81e-01	5.28e-08	2.68e-03
Nucleosome assembly	38	1.83e-07	1.69e-06	0.58200	-5.10e-01	2.81e-01	5.28e-08	2.68e-03
LTC4-CYSLTR mediated IL4 production	5	4.59e-02	1.13e-01	0.58200	-5.73e-02	-5.79e-01	8.24e-01	2.49e-02
FCGR activation	76	3.92e-13	9.84e-12	0.58200	-4.18e-01	4.05e-01	2.97e-10	1.06e-09
APC/C:Cdc20 mediated degradation of mitotic proteins	63	4.00e-13	9.91e-12	0.58000	-5.50e-01	1.84e-01	4.17e-14	1.15e-02
APC/C:Cdc20 mediated degradation of Securin	55	3.35e-12	6.88e-11	0.57900	-5.63e-01	1.36e-01	5.03e-13	8.03e-02
rRNA modification in the nucleus and cytosol	59	7.99e-13	1.80e-11	0.57800	-5.59e-01	1.48e-01	1.05e-13	5.00e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	9.50e-03	3.24e-02	0.57800	-1.45e-01	-5.59e-01	5.05e-01	1.04e-02
Amyloid fiber formation	52	4.37e-09	5.09e-08	0.57700	-4.10e-01	4.06e-01	3.21e-07	3.94e-07
SCF(Skp2)-mediated degradation of p27/p21	50	1.70e-11	3.04e-10	0.57500	-5.66e-01	1.01e-01	4.18e-12	2.17e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	2.75e-09	3.36e-08	0.57500	-5.57e-01	1.42e-01	4.12e-10	1.10e-01
Mitophagy	38	3.35e-07	2.96e-06	0.57400	-4.97e-01	2.88e-01	1.17e-07	2.10e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	1.63e-12	3.45e-11	0.57400	-5.45e-01	1.80e-01	1.74e-13	1.49e-02
Autodegradation of the E3 ubiquitin ligase COP1	38	1.07e-08	1.21e-07	0.57400	-5.62e-01	1.18e-01	2.05e-09	2.09e-01
SCF-beta-TrCP mediated degradation of Emi1	42	1.64e-09	2.11e-08	0.57300	-5.61e-01	1.17e-01	3.13e-10	1.91e-01
Release of apoptotic factors from the mitochondria	6	2.61e-02	7.38e-02	0.57200	-5.67e-01	-7.35e-02	1.61e-02	7.55e-01
Removal of the Flap Intermediate	14	4.10e-05	2.68e-04	0.57200	-5.00e-01	-2.77e-01	1.19e-03	7.27e-02
Defective LFNG causes SCDO3	5	1.03e-01	2.08e-01	0.57000	1.54e-01	-5.49e-01	5.50e-01	3.34e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	5.54e-13	1.30e-11	0.57000	-5.43e-01	1.76e-01	5.87e-14	1.47e-02
STAT3 nuclear events downstream of ALK signaling	11	1.85e-02	5.50e-02	0.57000	3.84e-01	-4.21e-01	2.73e-02	1.55e-02
RHO GTPases activate PKNs	46	5.94e-08	5.98e-07	0.57000	-3.91e-01	4.15e-01	4.46e-06	1.12e-06
RHOT1 GTPase cycle	5	1.08e-01	2.16e-01	0.56800	-1.64e-01	5.44e-01	5.26e-01	3.51e-02
Regulation of Complement cascade	96	1.34e-15	3.92e-14	0.56700	-4.12e-01	3.89e-01	2.96e-12	4.42e-11
Influenza Infection	154	1.77e-38	1.00e-36	0.56300	-5.62e-01	-3.75e-02	1.71e-33	4.22e-01
Regulation of PTEN localization	9	3.83e-02	9.90e-02	0.56300	-4.56e-01	3.31e-01	1.78e-02	8.59e-02
Signaling by RNF43 mutants	7	1.52e-02	4.73e-02	0.56300	5.56e-01	8.77e-02	1.08e-02	6.88e-01
Defective pyroptosis	27	5.74e-06	4.25e-05	0.56300	-5.44e-01	1.44e-01	9.86e-07	1.94e-01
Formyl peptide receptors bind formyl peptides and many other ligands	7	8.17e-02	1.76e-01	0.56300	-4.42e-01	3.49e-01	4.29e-02	1.10e-01
Binding and Uptake of Ligands by Scavenger Receptors	94	3.78e-15	1.07e-13	0.56200	-4.27e-01	3.66e-01	8.40e-13	8.28e-10
Role of LAT2/NTAL/LAB on calcium mobilization	77	1.97e-12	4.14e-11	0.56100	-3.80e-01	4.12e-01	7.77e-09	3.96e-10
Processive synthesis on the lagging strand	15	2.42e-05	1.63e-04	0.56100	-4.65e-01	-3.14e-01	1.84e-03	3.52e-02
Zygotic genome activation (ZGA)	5	1.13e-01	2.24e-01	0.56000	5.38e-01	-1.55e-01	3.73e-02	5.50e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	59	4.15e-11	7.22e-10	0.55900	-5.20e-01	2.05e-01	5.00e-12	6.40e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.18e-02	3.89e-02	0.55700	-4.82e-01	2.80e-01	3.86e-03	9.27e-02
Complex IV assembly	45	8.12e-10	1.10e-08	0.55600	-5.48e-01	9.57e-02	1.97e-10	2.67e-01
Defective factor IX causes hemophilia B	6	1.18e-01	2.31e-01	0.55600	-3.15e-01	4.58e-01	1.82e-01	5.19e-02
Methionine salvage pathway	6	1.64e-02	5.04e-02	0.55600	-4.81e-01	-2.78e-01	4.13e-02	2.38e-01
Aerobic respiration and respiratory electron transport	245	1.38e-52	2.06e-50	0.55600	-5.53e-01	5.51e-02	1.80e-50	1.37e-01
Malate-aspartate shuttle	8	6.15e-03	2.25e-02	0.55500	-5.26e-01	-1.77e-01	9.95e-03	3.85e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	9.16e-02	1.90e-01	0.55300	3.69e-01	-4.12e-01	9.08e-02	5.92e-02
Abacavir ADME	5	6.92e-02	1.54e-01	0.55300	5.52e-01	2.11e-02	3.25e-02	9.35e-01
Autodegradation of Cdh1 by Cdh1:APC/C	54	4.51e-11	7.79e-10	0.55100	-5.38e-01	1.19e-01	7.89e-12	1.31e-01
Coenzyme A biosynthesis	7	1.08e-02	3.60e-02	0.55000	-2.21e-01	-5.03e-01	3.10e-01	2.12e-02
Cross-presentation of soluble exogenous antigens (endosomes)	35	3.33e-07	2.95e-06	0.54700	-5.31e-01	1.34e-01	5.51e-08	1.70e-01
PCNA-Dependent Long Patch Base Excision Repair	21	6.38e-07	5.43e-06	0.54600	-4.28e-01	-3.39e-01	6.91e-04	7.15e-03
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	1.81e-02	5.42e-02	0.54500	-4.54e-01	-3.02e-01	5.43e-02	2.00e-01
Formation of tubulin folding intermediates by CCT/TriC	21	6.46e-04	3.16e-03	0.54500	-4.65e-01	2.84e-01	2.24e-04	2.44e-02
Josephin domain DUBs	10	2.97e-02	8.18e-02	0.54500	-4.68e-01	2.78e-01	1.03e-02	1.28e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	3.60e-04	1.87e-03	0.54300	-4.59e-01	2.89e-01	1.37e-04	1.64e-02
Pentose phosphate pathway	13	8.88e-03	3.07e-02	0.54300	-4.86e-01	2.40e-01	2.39e-03	1.33e-01
CDK-mediated phosphorylation and removal of Cdc6	60	8.94e-12	1.68e-10	0.54200	-5.28e-01	1.22e-01	1.44e-12	1.01e-01
Nectin/Necl trans heterodimerization	5	1.84e-01	3.11e-01	0.54200	4.47e-01	-3.05e-01	8.31e-02	2.37e-01
Noncanonical activation of NOTCH3	8	7.33e-02	1.61e-01	0.54200	-3.78e-01	3.88e-01	6.41e-02	5.75e-02
Synthesis of Dolichyl-phosphate	6	7.20e-02	1.59e-01	0.54100	-5.33e-01	9.67e-02	2.39e-02	6.82e-01
APOBEC3G mediated resistance to HIV-1 infection	5	3.50e-02	9.26e-02	0.54100	-3.59e-01	-4.05e-01	1.65e-01	1.17e-01
Phenylalanine metabolism	5	5.10e-02	1.23e-01	0.54000	-1.59e-01	-5.17e-01	5.39e-01	4.54e-02
Bicarbonate transporters	9	4.05e-02	1.03e-01	0.54000	4.80e-01	-2.48e-01	1.27e-02	1.98e-01
RNA Polymerase III Transcription Termination	23	1.16e-04	6.74e-04	0.53800	-5.12e-01	1.62e-01	2.09e-05	1.78e-01
Synthesis of diphthamide-EEF2	8	3.19e-02	8.64e-02	0.53700	-5.28e-01	9.80e-02	9.69e-03	6.31e-01
Adenylate cyclase activating pathway	8	4.37e-02	1.08e-01	0.53400	5.10e-01	-1.58e-01	1.24e-02	4.38e-01
Signal attenuation	9	3.83e-02	9.90e-02	0.53300	-2.10e-01	4.90e-01	2.74e-01	1.10e-02
Signaling by ROBO receptors	189	5.84e-38	3.22e-36	0.53300	-5.31e-01	4.47e-02	1.93e-36	2.89e-01
Miscellaneous substrates	7	6.73e-02	1.51e-01	0.53100	5.07e-01	-1.59e-01	2.03e-02	4.67e-01
Stabilization of p53	43	2.00e-08	2.16e-07	0.53000	-5.19e-01	1.09e-01	3.81e-09	2.15e-01
Degradation of GLI2 by the proteasome	45	2.38e-08	2.54e-07	0.53000	-5.09e-01	1.47e-01	3.34e-09	8.69e-02
Alpha-oxidation of phytanate	6	3.47e-02	9.22e-02	0.53000	-5.13e-01	-1.33e-01	2.94e-02	5.73e-01
Protein methylation	15	1.77e-03	7.74e-03	0.53000	-5.22e-01	9.00e-02	4.65e-04	5.46e-01
Regulation of APC/C activators between G1/S and early anaphase	68	1.42e-12	3.05e-11	0.53000	-5.15e-01	1.25e-01	2.10e-13	7.38e-02
Degradation of DVL	43	6.49e-08	6.50e-07	0.52900	-5.06e-01	1.54e-01	9.08e-09	8.15e-02
Condensation of Prophase Chromosomes	27	1.48e-04	8.39e-04	0.52900	-4.47e-01	2.83e-01	5.90e-05	1.09e-02
Regulation of CDH11 function	10	2.74e-02	7.65e-02	0.52800	4.89e-01	-2.00e-01	7.42e-03	2.75e-01
Orc1 removal from chromatin	58	3.86e-11	6.77e-10	0.52800	-5.18e-01	1.00e-01	8.29e-12	1.88e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	5.28e-03	2.00e-02	0.52800	-4.50e-01	2.75e-01	1.83e-03	5.65e-02
Complement cascade	100	3.29e-14	8.94e-13	0.52700	-3.99e-01	3.45e-01	5.52e-12	2.34e-09
Lipophagy	7	1.15e-01	2.27e-01	0.52700	-3.65e-01	3.79e-01	9.41e-02	8.23e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	2.69e-02	7.54e-02	0.52700	3.33e-02	-5.26e-01	8.71e-01	1.00e-02
Calcitonin-like ligand receptors	5	9.77e-02	2.00e-01	0.52600	5.26e-01	-1.01e-02	4.18e-02	9.69e-01
Reactions specific to the complex N-glycan synthesis pathway	7	1.05e-01	2.12e-01	0.52500	-4.43e-01	2.82e-01	4.26e-02	1.96e-01
Alternative complement activation	5	4.26e-02	1.06e-01	0.52500	-3.50e-01	-3.91e-01	1.75e-01	1.30e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	1.48e-07	1.39e-06	0.52400	-3.85e-01	-3.55e-01	8.73e-04	2.09e-03
Assembly of the pre-replicative complex	87	3.44e-15	9.92e-14	0.52400	-5.04e-01	1.40e-01	3.98e-16	2.38e-02
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	6	2.46e-02	7.02e-02	0.52300	2.97e-01	4.30e-01	2.08e-01	6.79e-02
Post-chaperonin tubulin folding pathway	18	4.15e-03	1.63e-02	0.52100	-3.98e-01	3.37e-01	3.47e-03	1.33e-02
APC/C:Cdc20 mediated degradation of Cyclin B	24	9.46e-05	5.57e-04	0.52100	-5.05e-01	1.28e-01	1.84e-05	2.76e-01
Regulation of RUNX3 expression and activity	45	4.74e-08	4.90e-07	0.52000	-4.99e-01	1.45e-01	6.75e-09	9.26e-02
Inactivation of CDC42 and RAC1	7	1.20e-01	2.34e-01	0.51900	-3.29e-01	4.01e-01	1.31e-01	6.61e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	3.63e-04	1.88e-03	0.51900	-4.84e-01	-1.86e-01	1.70e-03	2.28e-01
Interleukin-18 signaling	6	2.78e-02	7.73e-02	0.51800	4.46e-01	2.64e-01	5.85e-02	2.63e-01
Interleukin-9 signaling	8	8.41e-02	1.79e-01	0.51800	4.28e-01	-2.91e-01	3.59e-02	1.54e-01
Estrogen biosynthesis	5	6.18e-02	1.42e-01	0.51800	1.73e-01	4.88e-01	5.02e-01	5.90e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	5.24e-11	8.96e-10	0.51700	-5.05e-01	1.13e-01	9.02e-12	1.28e-01
Purine ribonucleoside monophosphate biosynthesis	9	1.01e-02	3.41e-02	0.51700	-5.09e-01	-9.08e-02	8.20e-03	6.37e-01
RORA activates gene expression	18	8.78e-04	4.17e-03	0.51600	5.05e-01	-1.05e-01	2.06e-04	4.41e-01
Miro GTPase Cycle	8	7.75e-02	1.68e-01	0.51500	-2.47e-01	4.52e-01	2.27e-01	2.70e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	2.39e-04	1.29e-03	0.51400	-4.28e-01	-2.86e-01	5.60e-03	6.41e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	5.39e-05	3.39e-04	0.51400	-4.84e-01	1.74e-01	9.29e-06	1.11e-01
Leading Strand Synthesis	14	2.10e-04	1.15e-03	0.51400	-3.32e-01	-3.93e-01	3.17e-02	1.09e-02
Polymerase switching	14	2.10e-04	1.15e-03	0.51400	-3.32e-01	-3.93e-01	3.17e-02	1.09e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	6.44e-07	5.46e-06	0.51200	-4.59e-01	-2.27e-01	7.00e-05	4.99e-02
G1/S DNA Damage Checkpoints	54	1.02e-09	1.35e-08	0.51200	-5.01e-01	1.06e-01	1.90e-10	1.78e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	18	5.00e-03	1.91e-02	0.51200	3.26e-01	-3.95e-01	1.67e-02	3.73e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	5	2.07e-01	3.38e-01	0.51100	4.48e-01	-2.45e-01	8.25e-02	3.42e-01
PD-1 signaling	28	1.36e-05	9.42e-05	0.51000	7.21e-02	-5.05e-01	5.09e-01	3.73e-06
GLI3 is processed to GLI3R by the proteasome	46	5.38e-08	5.53e-07	0.51000	-4.92e-01	1.36e-01	7.93e-09	1.10e-01
Regulation of CDH19 Expression and Function	6	1.72e-01	2.97e-01	0.51000	3.97e-01	-3.21e-01	9.25e-02	1.74e-01
Neurotransmitter clearance	6	1.44e-01	2.63e-01	0.51000	-2.21e-01	4.59e-01	3.48e-01	5.15e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	4.30e-02	1.07e-01	0.50900	-4.49e-01	2.40e-01	1.39e-02	1.88e-01
Diseases of hemostasis	15	9.30e-03	3.18e-02	0.50900	-2.48e-01	4.45e-01	9.69e-02	2.83e-03
Meiotic recombination	37	6.11e-06	4.51e-05	0.50900	-4.62e-01	2.15e-01	1.16e-06	2.38e-02
VLDLR internalisation and degradation	16	4.94e-03	1.89e-02	0.50800	-4.69e-01	1.95e-01	1.15e-03	1.76e-01
Displacement of DNA glycosylase by APEX1	9	9.50e-03	3.24e-02	0.50800	-4.90e-01	-1.35e-01	1.10e-02	4.85e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	8.13e-09	9.30e-08	0.50800	-4.88e-01	1.40e-01	1.12e-09	8.12e-02
Acetylcholine Neurotransmitter Release Cycle	11	1.66e-02	5.06e-02	0.50800	1.14e-01	-4.95e-01	5.13e-01	4.49e-03
PRC2 methylates histones and DNA	27	1.11e-04	6.46e-04	0.50800	-4.74e-01	1.81e-01	2.00e-05	1.03e-01
DNA Replication Pre-Initiation	103	9.25e-17	3.08e-15	0.50500	-4.88e-01	1.32e-01	1.09e-17	2.09e-02
PTK6 Regulates Cell Cycle	6	2.99e-02	8.19e-02	0.50500	-3.38e-01	-3.76e-01	1.52e-01	1.11e-01
Phosphorylation of CD3 and TCR zeta chains	27	2.57e-05	1.73e-04	0.50500	7.19e-02	-4.99e-01	5.18e-01	7.01e-06
Maturation of hRSV A proteins	13	2.55e-02	7.23e-02	0.50400	-3.50e-01	3.62e-01	2.87e-02	2.39e-02
Degradation of AXIN	42	2.19e-07	1.99e-06	0.50300	-4.90e-01	1.15e-01	3.84e-08	1.98e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	2.76e-02	7.69e-02	0.50300	4.66e-01	-1.90e-01	7.49e-03	2.75e-01
TNFR1-mediated ceramide production	6	3.27e-02	8.82e-02	0.50300	-2.83e-01	-4.15e-01	2.30e-01	7.80e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	23	8.25e-05	4.95e-04	0.50100	-5.00e-01	3.33e-02	3.26e-05	7.82e-01
MET activates RAP1 and RAC1	10	6.72e-03	2.42e-02	0.50100	1.26e-01	4.85e-01	4.91e-01	7.91e-03
Degradation of GLI1 by the proteasome	46	1.88e-07	1.73e-06	0.50100	-4.74e-01	1.61e-01	2.62e-08	5.89e-02
B-WICH complex positively regulates rRNA expression	45	1.89e-06	1.49e-05	0.50000	-4.24e-01	2.66e-01	8.65e-07	2.05e-03
FCERI mediated NF-kB activation	129	1.23e-16	4.03e-15	0.50000	-4.04e-01	2.95e-01	2.30e-15	7.41e-09
p53-Dependent G1 DNA Damage Response	52	4.11e-09	4.82e-08	0.49900	-4.91e-01	9.06e-02	9.17e-10	2.59e-01
p53-Dependent G1/S DNA damage checkpoint	52	4.11e-09	4.82e-08	0.49900	-4.91e-01	9.06e-02	9.17e-10	2.59e-01
Protein hydroxylation	17	2.06e-03	8.88e-03	0.49900	-4.88e-01	1.04e-01	4.97e-04	4.57e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	4.08e-10	5.84e-09	0.49800	-4.55e-01	2.02e-01	6.14e-11	3.63e-03
Presynaptic depolarization and calcium channel opening	8	1.08e-01	2.17e-01	0.49800	3.78e-01	-3.24e-01	6.40e-02	1.13e-01
Physiological factors	9	6.13e-03	2.25e-02	0.49700	3.76e-01	3.26e-01	5.10e-02	9.08e-02
Ketone body metabolism	8	5.85e-02	1.36e-01	0.49700	-4.83e-01	1.16e-01	1.79e-02	5.69e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	6.79e-03	2.44e-02	0.49700	2.72e-01	4.16e-01	1.57e-01	3.08e-02
Platelet Adhesion to exposed collagen	16	7.73e-03	2.72e-02	0.49700	-2.22e-01	4.45e-01	1.25e-01	2.08e-03
Carnitine shuttle	12	1.40e-02	4.44e-02	0.49300	1.02e-01	-4.82e-01	5.40e-01	3.82e-03
ABC transporter disorders	60	8.78e-09	9.98e-08	0.49300	-4.53e-01	1.95e-01	1.30e-09	9.13e-03
RUNX1 regulates expression of components of tight junctions	5	9.06e-02	1.89e-01	0.49300	1.18e-01	4.78e-01	6.48e-01	6.40e-02
Lagging Strand Synthesis	20	1.54e-05	1.05e-04	0.49300	-3.81e-01	-3.12e-01	3.17e-03	1.57e-02
APC/C-mediated degradation of cell cycle proteins	75	8.56e-12	1.62e-10	0.49200	-4.75e-01	1.29e-01	1.10e-12	5.25e-02
Regulation of mitotic cell cycle	75	8.56e-12	1.62e-10	0.49200	-4.75e-01	1.29e-01	1.10e-12	5.25e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	8.61e-02	1.82e-01	0.49100	-3.85e-01	3.04e-01	4.52e-02	1.14e-01
Sperm Motility And Taxes	6	4.93e-02	1.19e-01	0.49000	-1.71e-01	-4.59e-01	4.68e-01	5.16e-02
Disorders of Developmental Biology	12	4.07e-02	1.03e-01	0.48900	3.24e-01	-3.66e-01	5.22e-02	2.81e-02
Disorders of Nervous System Development	12	4.07e-02	1.03e-01	0.48900	3.24e-01	-3.66e-01	5.22e-02	2.81e-02
Loss of function of MECP2 in Rett syndrome	12	4.07e-02	1.03e-01	0.48900	3.24e-01	-3.66e-01	5.22e-02	2.81e-02
Pervasive developmental disorders	12	4.07e-02	1.03e-01	0.48900	3.24e-01	-3.66e-01	5.22e-02	2.81e-02
Androgen biosynthesis	5	1.16e-01	2.28e-01	0.48900	-4.87e-01	-4.18e-02	5.94e-02	8.71e-01
GDP-fucose biosynthesis	6	6.37e-02	1.45e-01	0.48800	-4.79e-01	-9.34e-02	4.22e-02	6.92e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	1.56e-01	2.78e-01	0.48700	3.18e-01	-3.69e-01	1.45e-01	9.08e-02
MASTL Facilitates Mitotic Progression	10	6.65e-02	1.50e-01	0.48700	-3.95e-01	2.85e-01	3.07e-02	1.18e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	2.93e-04	1.54e-03	0.48600	-4.82e-01	5.68e-02	8.92e-05	6.45e-01
rRNA modification in the mitochondrion	8	4.06e-02	1.03e-01	0.48600	-4.86e-01	2.61e-03	1.74e-02	9.90e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	1.41e-02	4.46e-02	0.48500	3.83e-01	-2.98e-01	7.98e-03	3.93e-02
Mismatch Repair	15	4.62e-04	2.33e-03	0.48500	-4.34e-01	-2.16e-01	3.57e-03	1.48e-01
NIK–>noncanonical NF-kB signaling	46	5.90e-08	5.97e-07	0.48500	-4.80e-01	6.84e-02	1.73e-08	4.22e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	1.13e-01	2.24e-01	0.48500	-4.04e-01	2.67e-01	4.76e-02	1.90e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	2.15e-04	1.17e-03	0.48400	-4.71e-01	1.09e-01	4.53e-05	3.48e-01
Synthesis of Ketone Bodies	6	1.08e-01	2.17e-01	0.48300	-4.81e-01	4.89e-02	4.13e-02	8.36e-01
Cytosolic tRNA aminoacylation	24	7.05e-05	4.28e-04	0.48200	-4.82e-01	-2.87e-03	4.27e-05	9.81e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.97e-01	3.26e-01	0.48200	1.31e-01	-4.64e-01	6.13e-01	7.21e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	83	4.99e-10	6.94e-09	0.48200	-3.24e-01	3.56e-01	3.22e-07	2.06e-08
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.25e-04	7.20e-04	0.48100	-4.62e-01	1.35e-01	2.31e-05	2.15e-01
Switching of origins to a post-replicative state	79	6.70e-13	1.54e-11	0.48100	-4.76e-01	7.01e-02	2.43e-13	2.82e-01
APC-Cdc20 mediated degradation of Nek2A	26	3.16e-04	1.65e-03	0.48100	-4.55e-01	1.57e-01	5.94e-05	1.66e-01
Interleukin-15 signaling	14	1.82e-02	5.43e-02	0.47900	4.33e-01	-2.04e-01	5.01e-03	1.87e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	2.19e-02	6.37e-02	0.47800	-1.84e-01	4.42e-01	2.50e-01	5.83e-03
Protein localization	157	2.68e-27	1.29e-25	0.47800	-4.78e-01	-2.33e-03	3.96e-25	9.60e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	1.64e-02	5.04e-02	0.47700	-3.72e-01	2.99e-01	1.00e-02	3.81e-02
Interconversion of nucleotide di- and triphosphates	27	4.83e-05	3.11e-04	0.47700	-4.76e-01	3.48e-02	1.87e-05	7.54e-01
VEGF binds to VEGFR leading to receptor dimerization	5	2.50e-01	3.89e-01	0.47600	-4.24e-01	2.17e-01	1.01e-01	4.01e-01
VEGF ligand-receptor interactions	5	2.50e-01	3.89e-01	0.47600	-4.24e-01	2.17e-01	1.01e-01	4.01e-01
Glycogen synthesis	11	6.30e-02	1.44e-01	0.47500	-3.49e-01	3.21e-01	4.48e-02	6.49e-02
Resolution of Abasic Sites (AP sites)	38	3.07e-09	3.73e-08	0.47500	-3.58e-01	-3.11e-01	1.32e-04	8.93e-04
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	1.39e-02	4.43e-02	0.47400	-4.10e-01	2.38e-01	4.54e-03	9.91e-02
NFE2L2 regulates pentose phosphate pathway genes	8	1.81e-02	5.42e-02	0.47400	2.51e-01	4.02e-01	2.20e-01	4.90e-02
ROBO receptors bind AKAP5	7	1.50e-01	2.70e-01	0.47300	2.25e-01	-4.16e-01	3.03e-01	5.65e-02
Platelet degranulation	106	3.55e-12	7.14e-11	0.47100	-3.65e-01	2.98e-01	8.22e-11	1.19e-07
GP1b-IX-V activation signalling	12	4.92e-02	1.19e-01	0.47100	-2.87e-01	3.73e-01	8.51e-02	2.52e-02
Defective HLCS causes multiple carboxylase deficiency	7	2.87e-02	7.93e-02	0.47000	-3.38e-01	-3.27e-01	1.22e-01	1.34e-01
Base Excision Repair	57	6.07e-11	1.02e-09	0.47000	-4.65e-01	-6.73e-02	1.25e-09	3.79e-01
Telomere Extension By Telomerase	23	1.72e-03	7.56e-03	0.47000	-4.27e-01	1.97e-01	3.98e-04	1.03e-01
Removal of the Flap Intermediate from the C-strand	17	2.34e-04	1.27e-03	0.46800	-3.92e-01	-2.56e-01	5.13e-03	6.81e-02
Activation of SMO	13	3.54e-02	9.35e-02	0.46800	3.97e-01	-2.47e-01	1.31e-02	1.22e-01
Translesion synthesis by REV1	16	9.87e-04	4.65e-03	0.46800	-4.54e-01	-1.12e-01	1.66e-03	4.40e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	3.26e-03	1.33e-02	0.46800	-4.50e-01	-1.28e-01	4.98e-03	4.26e-01
DNA Replication	128	2.84e-19	1.06e-17	0.46700	-4.62e-01	6.76e-02	1.62e-19	1.87e-01
RUNX3 regulates BCL2L11 (BIM) transcription	5	1.66e-01	2.89e-01	0.46600	-2.09e-02	4.66e-01	9.35e-01	7.12e-02
Glycerophospholipid catabolism	6	1.80e-01	3.05e-01	0.46600	1.63e-01	-4.37e-01	4.90e-01	6.40e-02
RUNX1 regulates transcription of genes involved in WNT signaling	5	9.92e-02	2.02e-01	0.46500	4.25e-01	1.87e-01	9.98e-02	4.68e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	1.97e-02	5.81e-02	0.46400	3.73e-01	-2.76e-01	9.77e-03	5.57e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	1.20e-01	2.34e-01	0.46400	-2.58e-02	4.63e-01	9.13e-01	4.95e-02
Cohesin Loading onto Chromatin	10	3.77e-02	9.82e-02	0.46400	4.58e-01	-7.16e-02	1.21e-02	6.95e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	5.18e-02	1.24e-01	0.46400	-2.67e-01	3.79e-01	1.10e-01	2.29e-02
Transport of connexons to the plasma membrane	12	5.18e-02	1.24e-01	0.46400	-2.67e-01	3.79e-01	1.10e-01	2.29e-02
Translesion synthesis by POLI	17	8.13e-04	3.90e-03	0.46300	-4.53e-01	-9.83e-02	1.23e-03	4.83e-01
Mitochondrial Fatty Acid Beta-Oxidation	36	1.49e-07	1.39e-06	0.46200	-4.41e-01	-1.39e-01	4.63e-06	1.49e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	6.24e-03	2.28e-02	0.46200	-4.18e-01	-1.97e-01	1.63e-02	2.59e-01
Digestion	5	1.69e-01	2.94e-01	0.46200	-1.48e-02	4.61e-01	9.54e-01	7.41e-02
Telomere Maintenance	78	1.12e-11	2.06e-10	0.46100	-4.56e-01	7.21e-02	3.37e-12	2.71e-01
RNA Polymerase I Transcription Termination	30	4.67e-05	3.03e-04	0.46100	-4.58e-01	5.53e-02	1.42e-05	6.00e-01
Intrinsic Pathway of Fibrin Clot Formation	15	2.79e-02	7.75e-02	0.46100	-3.58e-01	2.90e-01	1.65e-02	5.17e-02
Regulation of RUNX1 Expression and Activity	18	9.25e-03	3.17e-02	0.46000	4.11e-01	-2.07e-01	2.54e-03	1.28e-01
Insulin receptor recycling	24	3.47e-03	1.41e-02	0.46000	-3.08e-01	3.42e-01	9.09e-03	3.74e-03
Sodium/Proton exchangers	7	1.74e-01	2.99e-01	0.46000	3.94e-01	-2.36e-01	7.07e-02	2.79e-01
Branched-chain ketoacid dehydrogenase kinase deficiency	5	3.08e-01	4.49e-01	0.45900	-3.04e-01	3.44e-01	2.39e-01	1.83e-01
Fructose metabolism	7	3.77e-02	9.82e-02	0.45900	-2.32e-01	-3.97e-01	2.89e-01	6.92e-02
LGI-ADAM interactions	9	1.13e-01	2.24e-01	0.45900	2.60e-01	-3.78e-01	1.78e-01	4.96e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.11e-04	1.63e-03	0.45800	-4.44e-01	1.10e-01	6.43e-05	3.23e-01
Response to elevated platelet cytosolic Ca2+	110	5.37e-12	1.05e-10	0.45800	-3.60e-01	2.82e-01	6.38e-11	3.22e-07
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	1.86e-01	3.13e-01	0.45600	2.53e-01	-3.79e-01	2.47e-01	8.23e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.38e-02	4.42e-02	0.45500	-4.29e-01	-1.50e-01	1.88e-02	4.12e-01
Adherens junctions interactions	41	5.26e-05	3.34e-04	0.45500	3.81e-01	-2.47e-01	2.37e-05	6.17e-03
Synthesis of DNA	108	3.44e-17	1.17e-15	0.45400	-4.54e-01	-1.17e-03	3.41e-16	9.83e-01
FCGR3A-mediated phagocytosis	121	9.77e-13	2.12e-11	0.45400	-3.12e-01	3.30e-01	3.02e-09	3.74e-10
Leishmania phagocytosis	121	9.77e-13	2.12e-11	0.45400	-3.12e-01	3.30e-01	3.02e-09	3.74e-10
Parasite infection	121	9.77e-13	2.12e-11	0.45400	-3.12e-01	3.30e-01	3.02e-09	3.74e-10
Digestion and absorption	7	1.57e-01	2.80e-01	0.45400	-1.75e-01	4.19e-01	4.24e-01	5.51e-02
Mitochondrial tRNA aminoacylation	21	1.68e-04	9.40e-04	0.45300	-4.36e-01	-1.23e-01	5.34e-04	3.30e-01
Synthesis of PIPs at the ER membrane	5	3.12e-01	4.53e-01	0.45300	3.60e-01	-2.75e-01	1.63e-01	2.87e-01
RUNX1 regulates estrogen receptor mediated transcription	6	1.87e-01	3.14e-01	0.45200	4.32e-01	-1.34e-01	6.71e-02	5.69e-01
Dectin-1 mediated noncanonical NF-kB signaling	48	2.14e-07	1.95e-06	0.45200	-4.49e-01	5.28e-02	7.30e-08	5.27e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	4.94e-04	2.47e-03	0.45200	2.76e-01	-3.57e-01	6.01e-03	3.82e-04
Activation of NOXA and translocation to mitochondria	5	3.09e-01	4.50e-01	0.45100	2.56e-01	-3.72e-01	3.22e-01	1.50e-01
Metabolism of folate and pterines	16	5.66e-03	2.12e-02	0.45000	-4.48e-01	4.23e-02	1.89e-03	7.70e-01
Type I hemidesmosome assembly	8	1.60e-01	2.82e-01	0.45000	3.52e-01	-2.81e-01	8.44e-02	1.69e-01
RHOT2 GTPase cycle	7	1.80e-01	3.05e-01	0.45000	-2.13e-01	3.96e-01	3.28e-01	6.98e-02
Somitogenesis	41	6.64e-06	4.86e-05	0.44900	-4.37e-01	1.03e-01	1.25e-06	2.56e-01
Platelet Aggregation (Plug Formation)	30	9.97e-04	4.69e-03	0.44900	-2.61e-01	3.65e-01	1.33e-02	5.39e-04
Regulation of RAS by GAPs	55	6.74e-07	5.68e-06	0.44900	-4.14e-01	1.72e-01	1.06e-07	2.71e-02
Defects in biotin (Btn) metabolism	8	2.70e-02	7.58e-02	0.44900	-2.43e-01	-3.77e-01	2.34e-01	6.47e-02
Asymmetric localization of PCP proteins	49	1.58e-06	1.25e-05	0.44800	-4.27e-01	1.38e-01	2.37e-07	9.55e-02
Role of phospholipids in phagocytosis	88	3.09e-09	3.73e-08	0.44800	-3.19e-01	3.14e-01	2.27e-07	3.44e-07
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.52e-03	1.06e-02	0.44700	-4.34e-01	1.09e-01	5.80e-04	3.87e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.52e-03	1.06e-02	0.44700	-4.34e-01	1.09e-01	5.80e-04	3.87e-01
Creatine metabolism	6	1.61e-01	2.83e-01	0.44600	6.73e-02	-4.41e-01	7.75e-01	6.13e-02
tRNA Aminoacylation	42	1.55e-07	1.45e-06	0.44600	-4.41e-01	-6.61e-02	7.51e-07	4.58e-01
Condensation of Prometaphase Chromosomes	11	8.56e-02	1.81e-01	0.44600	-3.45e-01	2.82e-01	4.73e-02	1.06e-01
Interleukin receptor SHC signaling	23	2.14e-03	9.17e-03	0.44400	4.22e-01	-1.38e-01	4.55e-04	2.51e-01
Interleukin-20 family signaling	17	1.96e-02	5.78e-02	0.44400	3.76e-01	-2.36e-01	7.21e-03	9.20e-02
p75NTR recruits signalling complexes	12	3.82e-02	9.89e-02	0.44400	-4.26e-01	1.27e-01	1.07e-02	4.45e-01
Interleukin-6 signaling	11	4.52e-02	1.11e-01	0.44400	4.31e-01	-1.07e-01	1.33e-02	5.38e-01
Signaling by FLT3 fusion proteins	18	1.28e-02	4.12e-02	0.44400	3.96e-01	-2.00e-01	3.59e-03	1.42e-01
Fatty acids	6	1.98e-01	3.28e-01	0.44400	4.24e-01	-1.31e-01	7.23e-02	5.79e-01
Signaling by ALK	24	4.64e-03	1.79e-02	0.44300	3.57e-01	-2.64e-01	2.50e-03	2.53e-02
Regulation of RUNX2 expression and activity	54	1.98e-07	1.81e-06	0.44300	-4.33e-01	9.49e-02	3.69e-08	2.28e-01
DNA replication initiation	8	5.13e-02	1.23e-01	0.44300	-4.37e-01	-7.22e-02	3.24e-02	7.24e-01
Translesion synthesis by POLK	17	1.45e-03	6.57e-03	0.44300	-4.31e-01	-9.91e-02	2.07e-03	4.79e-01
FCERI mediated MAPK activation	93	1.89e-09	2.40e-08	0.44100	-3.15e-01	3.08e-01	1.44e-07	2.73e-07
Regulation of PTEN stability and activity	55	9.82e-07	8.08e-06	0.44100	-4.09e-01	1.64e-01	1.51e-07	3.53e-02
Dual Incision in GG-NER	41	1.09e-07	1.05e-06	0.44100	-4.24e-01	-1.21e-01	2.66e-06	1.81e-01
Budding and maturation of HIV virion	26	9.26e-04	4.38e-03	0.44000	-4.23e-01	1.23e-01	1.91e-04	2.76e-01
Anchoring fibril formation	10	1.46e-02	4.58e-02	0.44000	1.99e-01	3.92e-01	2.75e-01	3.17e-02
Ubiquinol biosynthesis	13	1.72e-02	5.21e-02	0.44000	-4.38e-01	3.22e-02	6.20e-03	8.41e-01
mRNA Splicing - Minor Pathway	50	5.49e-08	5.61e-07	0.43900	-4.39e-01	-1.08e-02	7.63e-08	8.95e-01
Regulation of MECP2 expression and activity	29	1.79e-03	7.81e-03	0.43900	3.47e-01	-2.70e-01	1.23e-03	1.20e-02
Interleukin-2 signaling	11	6.63e-02	1.49e-01	0.43900	4.04e-01	-1.71e-01	2.02e-02	3.26e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	7.45e-02	1.63e-01	0.43900	-2.77e-01	3.40e-01	9.70e-02	4.12e-02
Sema4D mediated inhibition of cell attachment and migration	7	1.99e-01	3.28e-01	0.43800	-3.83e-01	2.14e-01	7.95e-02	3.27e-01
Activated NTRK3 signals through PI3K	5	1.60e-01	2.82e-01	0.43800	4.32e-01	7.62e-02	9.47e-02	7.68e-01
Formation of the Early Elongation Complex	33	2.29e-05	1.55e-04	0.43800	-4.38e-01	5.89e-03	1.33e-05	9.53e-01
Formation of the HIV-1 Early Elongation Complex	33	2.29e-05	1.55e-04	0.43800	-4.38e-01	5.89e-03	1.33e-05	9.53e-01
Synthesis of wybutosine at G37 of tRNA(Phe)	6	1.22e-01	2.36e-01	0.43600	-4.33e-01	-5.08e-02	6.61e-02	8.29e-01
Vitamin B1 (thiamin) metabolism	5	2.83e-01	4.25e-01	0.43600	-4.10e-01	1.48e-01	1.12e-01	5.68e-01
Recognition of DNA damage by PCNA-containing replication complex	30	1.46e-05	1.01e-04	0.43600	-4.25e-01	-9.50e-02	5.54e-05	3.68e-01
FCERI mediated Ca+2 mobilization	92	3.90e-09	4.62e-08	0.43500	-3.02e-01	3.14e-01	5.45e-07	2.00e-07
MECP2 regulates transcription factors	5	2.62e-01	4.05e-01	0.43500	4.21e-01	-1.11e-01	1.03e-01	6.68e-01
FLT3 signaling by CBL mutants	7	1.31e-01	2.48e-01	0.43500	-4.30e-01	6.42e-02	4.87e-02	7.69e-01
Metabolism of cofactors	25	2.33e-04	1.26e-03	0.43500	-4.34e-01	-2.40e-02	1.70e-04	8.36e-01
Metabolism of amino acids and derivatives	308	8.02e-43	6.45e-41	0.43400	-4.34e-01	6.84e-03	2.36e-39	8.36e-01
Interleukin-7 signaling	21	1.70e-03	7.50e-03	0.43400	4.33e-01	-3.34e-02	5.98e-04	7.91e-01
Negative feedback regulation of MAPK pathway	6	2.81e-01	4.23e-01	0.43300	-2.71e-01	3.38e-01	2.50e-01	1.52e-01
Pexophagy	10	1.92e-02	5.67e-02	0.43300	-4.03e-01	-1.59e-01	2.74e-02	3.84e-01
Advanced glycosylation endproduct receptor signaling	12	8.07e-02	1.74e-01	0.43300	-3.26e-01	2.85e-01	5.03e-02	8.76e-02
Ras activation upon Ca2+ influx through NMDA receptor	18	2.05e-02	6.02e-02	0.43300	3.58e-01	-2.43e-01	8.63e-03	7.38e-02
Prevention of phagosomal-lysosomal fusion	9	1.29e-01	2.44e-01	0.43100	-3.84e-01	1.97e-01	4.61e-02	3.07e-01
Processive synthesis on the C-strand of the telomere	19	3.81e-04	1.96e-03	0.43100	-3.68e-01	-2.24e-01	5.45e-03	9.08e-02
MET receptor recycling	9	3.40e-02	9.13e-02	0.43100	1.21e-01	4.13e-01	5.29e-01	3.17e-02
Erythrocytes take up oxygen and release carbon dioxide	7	6.27e-02	1.43e-01	0.43000	3.94e-01	1.72e-01	7.10e-02	4.30e-01
Acetylcholine regulates insulin secretion	9	1.29e-01	2.45e-01	0.43000	1.93e-01	-3.84e-01	3.16e-01	4.59e-02
Interleukin-6 family signaling	20	1.20e-02	3.93e-02	0.43000	3.74e-01	-2.11e-01	3.76e-03	1.03e-01
Activation of BAD and translocation to mitochondria	15	4.60e-02	1.13e-01	0.42900	-3.17e-01	2.89e-01	3.33e-02	5.29e-02
Cellular response to hypoxia	59	3.20e-07	2.85e-06	0.42900	-4.11e-01	1.22e-01	4.72e-08	1.05e-01
Prostanoid ligand receptors	8	1.95e-01	3.23e-01	0.42900	-2.98e-01	3.08e-01	1.45e-01	1.31e-01
Chromosome Maintenance	103	5.80e-13	1.35e-11	0.42800	-4.21e-01	7.70e-02	1.42e-13	1.77e-01
Spry regulation of FGF signaling	16	3.82e-02	9.90e-02	0.42800	-2.99e-01	3.07e-01	3.87e-02	3.35e-02
Nucleotide biosynthesis	12	7.02e-03	2.50e-02	0.42800	-3.54e-01	-2.41e-01	3.38e-02	1.48e-01
Termination of translesion DNA synthesis	32	7.69e-06	5.59e-05	0.42700	-4.10e-01	-1.20e-01	6.07e-05	2.42e-01
Synthesis of GDP-mannose	6	2.70e-01	4.13e-01	0.42700	-3.72e-01	2.08e-01	1.14e-01	3.78e-01
Molybdenum cofactor biosynthesis	6	1.09e-01	2.18e-01	0.42600	-1.25e-01	-4.07e-01	5.95e-01	8.45e-02
Neurotoxicity of clostridium toxins	9	1.14e-01	2.25e-01	0.42400	1.37e-01	-4.01e-01	4.77e-01	3.71e-02
Receptor Mediated Mitophagy	11	9.73e-02	1.99e-01	0.42400	-3.62e-01	2.21e-01	3.77e-02	2.05e-01
Glutathione conjugation	28	8.10e-05	4.87e-04	0.42400	-4.19e-01	-6.23e-02	1.24e-04	5.68e-01
Selective autophagy	77	9.96e-08	9.77e-07	0.42300	-3.59e-01	2.24e-01	5.19e-08	6.73e-04
Defective GALNT3 causes HFTC	9	1.04e-01	2.11e-01	0.42200	4.08e-01	-1.10e-01	3.42e-02	5.68e-01
Proton-coupled monocarboxylate transport	6	1.94e-01	3.23e-01	0.42200	-6.14e-02	4.18e-01	7.94e-01	7.65e-02
Uptake of dietary cobalamins into enterocytes	6	2.42e-01	3.81e-01	0.42200	1.42e-01	-3.97e-01	5.47e-01	9.21e-02
Metabolism of RNA	718	3.09e-90	2.99e-87	0.42200	-4.21e-01	1.86e-02	4.29e-83	3.96e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	7.09e-03	2.52e-02	0.42000	-3.54e-01	2.26e-01	2.66e-03	5.50e-02
Phosphorylation of the APC/C	20	4.28e-03	1.67e-02	0.42000	-4.16e-01	5.53e-02	1.28e-03	6.68e-01
tRNA modification in the nucleus and cytosol	43	2.95e-07	2.65e-06	0.41900	-4.06e-01	-1.05e-01	4.10e-06	2.34e-01
Transport of RCbl within the body	8	2.10e-01	3.42e-01	0.41900	-2.96e-01	2.96e-01	1.47e-01	1.47e-01
Aflatoxin activation and detoxification	14	3.61e-03	1.45e-02	0.41800	-3.07e-01	-2.84e-01	4.67e-02	6.54e-02
Keratan sulfate degradation	9	1.47e-01	2.67e-01	0.41700	-1.91e-01	3.71e-01	3.20e-01	5.40e-02
IRAK1 recruits IKK complex	14	6.77e-02	1.52e-01	0.41600	-2.94e-01	2.94e-01	5.67e-02	5.70e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	6.77e-02	1.52e-01	0.41600	-2.94e-01	2.94e-01	5.67e-02	5.70e-02
Regulation of actin dynamics for phagocytic cup formation	123	6.17e-11	1.03e-09	0.41500	-2.93e-01	2.94e-01	1.91e-08	1.77e-08
InlA-mediated entry of Listeria monocytogenes into host cells	9	9.41e-02	1.94e-01	0.41500	-4.10e-01	6.37e-02	3.32e-02	7.41e-01
Signaling by LTK	10	1.20e-01	2.33e-01	0.41500	3.72e-01	-1.84e-01	4.18e-02	3.13e-01
Activation of NF-kappaB in B cells	54	4.65e-06	3.46e-05	0.41400	-3.90e-01	1.41e-01	7.23e-07	7.28e-02
Cytosolic iron-sulfur cluster assembly	13	8.53e-03	2.97e-02	0.41300	-3.77e-01	-1.69e-01	1.86e-02	2.90e-01
TYSND1 cleaves peroxisomal proteins	7	1.25e-01	2.39e-01	0.41300	-4.13e-01	-1.31e-02	5.86e-02	9.52e-01
eNOS activation	12	6.34e-02	1.44e-01	0.41300	-3.92e-01	1.30e-01	1.89e-02	4.36e-01
NoRC negatively regulates rRNA expression	60	5.22e-07	4.50e-06	0.41200	-3.99e-01	1.02e-01	8.61e-08	1.70e-01
Passive transport by Aquaporins	6	1.73e-01	2.98e-01	0.41000	1.04e-02	4.10e-01	9.65e-01	8.18e-02
Syndecan interactions	26	7.43e-03	2.62e-02	0.41000	-2.65e-01	3.13e-01	1.94e-02	5.70e-03
NrCAM interactions	6	3.18e-01	4.60e-01	0.41000	2.47e-01	-3.27e-01	2.95e-01	1.65e-01
Negative epigenetic regulation of rRNA expression	63	2.47e-07	2.23e-06	0.41000	-3.99e-01	9.43e-02	4.30e-08	1.95e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	3.43e-02	9.16e-02	0.41000	-4.06e-01	5.60e-02	1.12e-02	7.27e-01
Urea cycle	7	2.64e-01	4.07e-01	0.41000	-3.25e-01	2.50e-01	1.37e-01	2.53e-01
Phenylalanine and tyrosine metabolism	9	4.44e-02	1.09e-01	0.40900	-3.88e-01	-1.32e-01	4.40e-02	4.94e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	1.72e-01	2.97e-01	0.40900	-1.46e-01	-3.82e-01	5.72e-01	1.39e-01
Apoptotic factor-mediated response	19	4.75e-03	1.83e-02	0.40900	-4.09e-01	7.31e-03	2.03e-03	9.56e-01
Polymerase switching on the C-strand of the telomere	26	4.81e-05	3.11e-04	0.40900	-2.64e-01	-3.12e-01	1.99e-02	5.83e-03
Nef mediated downregulation of MHC class I complex cell surface expression	10	1.52e-01	2.73e-01	0.40900	-2.55e-01	3.19e-01	1.62e-01	8.05e-02
Aggrephagy	34	1.64e-03	7.28e-03	0.40800	-3.25e-01	2.46e-01	1.02e-03	1.32e-02
Pausing and recovery of Tat-mediated HIV elongation	30	3.32e-04	1.73e-03	0.40700	-4.06e-01	3.21e-02	1.19e-04	7.61e-01
Tat-mediated HIV elongation arrest and recovery	30	3.32e-04	1.73e-03	0.40700	-4.06e-01	3.21e-02	1.19e-04	7.61e-01
Triglyceride biosynthesis	10	3.95e-02	1.01e-01	0.40700	3.97e-01	8.77e-02	2.96e-02	6.31e-01
Processing and activation of SUMO	10	6.94e-02	1.54e-01	0.40700	-4.05e-01	3.16e-02	2.64e-02	8.63e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.72e-02	7.60e-02	0.40600	-3.94e-01	-9.95e-02	2.37e-02	5.68e-01
Specification of primordial germ cells	6	1.65e-01	2.88e-01	0.40600	4.04e-01	4.06e-02	8.64e-02	8.63e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	9.16e-02	1.90e-01	0.40600	3.96e-01	-9.00e-02	3.01e-02	6.22e-01
Mitochondrial Uncoupling	6	1.31e-01	2.48e-01	0.40600	-1.26e-01	-3.86e-01	5.94e-01	1.01e-01
Class I peroxisomal membrane protein import	20	7.58e-04	3.67e-03	0.40600	-3.61e-01	-1.85e-01	5.20e-03	1.52e-01
Formation of TC-NER Pre-Incision Complex	51	1.00e-06	8.16e-06	0.40500	-4.04e-01	1.67e-02	5.81e-07	8.36e-01
Assembly of active LPL and LIPC lipase complexes	10	1.35e-01	2.51e-01	0.40500	-1.86e-01	3.59e-01	3.08e-01	4.92e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	2.40e-01	3.78e-01	0.40400	3.65e-01	-1.73e-01	9.41e-02	4.27e-01
RHO GTPases activate IQGAPs	25	5.21e-03	1.97e-02	0.40400	-1.54e-01	3.74e-01	1.81e-01	1.22e-03
Toxicity of botulinum toxin type D (botD)	5	3.57e-01	4.99e-01	0.40300	1.64e-01	-3.69e-01	5.26e-01	1.54e-01
Toxicity of botulinum toxin type F (botF)	5	3.57e-01	4.99e-01	0.40300	1.64e-01	-3.69e-01	5.26e-01	1.54e-01
Interleukin-1 processing	8	2.38e-01	3.76e-01	0.40100	2.74e-01	-2.93e-01	1.79e-01	1.52e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	4.08e-01	5.54e-01	0.40000	3.01e-01	-2.64e-01	2.44e-01	3.07e-01
The activation of arylsulfatases	10	1.57e-01	2.80e-01	0.40000	-3.31e-01	2.25e-01	6.97e-02	2.19e-01
2-LTR circle formation	7	7.64e-02	1.67e-01	0.40000	-2.76e-01	-2.89e-01	2.05e-01	1.85e-01
Senescence-Associated Secretory Phenotype (SASP)	65	6.76e-06	4.93e-05	0.39900	-3.28e-01	2.28e-01	4.75e-06	1.49e-03
Regulated proteolysis of p75NTR	11	1.20e-01	2.34e-01	0.39900	-1.90e-01	3.51e-01	2.74e-01	4.38e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	76	1.22e-08	1.36e-07	0.39900	-3.93e-01	6.68e-02	3.00e-09	3.14e-01
DNA strand elongation	32	1.04e-05	7.34e-05	0.39900	-3.27e-01	-2.27e-01	1.35e-03	2.61e-02
RSK activation	7	2.17e-01	3.51e-01	0.39800	-1.16e-01	3.81e-01	5.94e-01	8.09e-02
Protein lipoylation	10	3.96e-02	1.02e-01	0.39700	-3.79e-01	-1.20e-01	3.81e-02	5.10e-01
Signaling by the B Cell Receptor (BCR)	150	3.38e-12	6.88e-11	0.39700	-3.08e-01	2.50e-01	7.65e-11	1.21e-07
BBSome-mediated cargo-targeting to cilium	22	4.01e-04	2.05e-03	0.39600	-2.31e-01	-3.22e-01	6.12e-02	8.85e-03
Glycosphingolipid biosynthesis	15	1.32e-02	4.25e-02	0.39600	3.93e-01	4.62e-02	8.40e-03	7.56e-01
Long-term potentiation	18	4.17e-02	1.04e-01	0.39500	2.42e-01	-3.12e-01	7.60e-02	2.18e-02
Diseases associated with N-glycosylation of proteins	20	9.52e-03	3.24e-02	0.39500	-3.88e-01	7.10e-02	2.65e-03	5.83e-01
Myogenesis	21	6.45e-03	2.33e-02	0.39400	3.91e-01	-5.36e-02	1.94e-03	6.71e-01
Diseases of branched-chain amino acid catabolism	13	3.32e-02	8.93e-02	0.39400	-3.94e-01	5.26e-03	1.39e-02	9.74e-01
Recycling of bile acids and salts	10	1.66e-01	2.89e-01	0.39400	3.28e-01	-2.18e-01	7.26e-02	2.33e-01
Infection with Mycobacterium tuberculosis	26	1.15e-02	3.80e-02	0.39300	-2.79e-01	2.77e-01	1.39e-02	1.45e-02
TP53 Regulates Transcription of Death Receptors and Ligands	12	9.21e-02	1.91e-01	0.39300	3.63e-01	-1.49e-01	2.94e-02	3.70e-01
Heme degradation	11	1.25e-01	2.40e-01	0.39300	-3.49e-01	1.79e-01	4.48e-02	3.04e-01
Degradation of cysteine and homocysteine	13	1.82e-02	5.43e-02	0.39300	-3.79e-01	-1.01e-01	1.79e-02	5.27e-01
Signaling by FGFR2 IIIa TM	18	1.03e-02	3.44e-02	0.39200	-3.91e-01	1.50e-02	4.05e-03	9.13e-01
FGFR2 alternative splicing	25	5.13e-03	1.95e-02	0.38900	-3.74e-01	1.06e-01	1.19e-03	3.57e-01
mRNA Capping	29	6.06e-04	2.98e-03	0.38900	-3.89e-01	4.08e-03	2.91e-04	9.70e-01
DNA Damage Recognition in GG-NER	38	9.21e-05	5.46e-04	0.38800	-3.87e-01	2.70e-02	3.56e-05	7.73e-01
PERK regulates gene expression	30	2.46e-03	1.04e-02	0.38800	-3.66e-01	1.30e-01	5.28e-04	2.16e-01
Cyclin E associated events during G1/S transition	73	1.31e-07	1.24e-06	0.38800	-3.78e-01	8.71e-02	2.31e-08	1.98e-01
Downregulation of ERBB4 signaling	8	1.46e-01	2.65e-01	0.38800	-3.86e-01	3.44e-02	5.85e-02	8.66e-01
G2/M Checkpoints	126	9.47e-12	1.76e-10	0.38700	-3.67e-01	1.21e-01	1.05e-12	1.87e-02
SARS-CoV-2 modulates autophagy	11	2.29e-02	6.61e-02	0.38700	-2.74e-01	-2.73e-01	1.16e-01	1.17e-01
TGFBR3 PTM regulation	10	1.89e-01	3.17e-01	0.38600	-2.55e-01	2.90e-01	1.63e-01	1.12e-01
Adenylate cyclase inhibitory pathway	11	7.26e-02	1.60e-01	0.38600	3.84e-01	-3.43e-02	2.72e-02	8.44e-01
Nef Mediated CD4 Down-regulation	9	1.40e-01	2.57e-01	0.38600	-3.78e-01	7.98e-02	4.98e-02	6.79e-01
Smooth Muscle Contraction	34	3.62e-03	1.46e-02	0.38500	-2.82e-01	2.63e-01	4.45e-03	7.98e-03
Axonal growth inhibition (RHOA activation)	7	3.05e-01	4.46e-01	0.38500	-3.12e-01	2.26e-01	1.53e-01	3.01e-01
p75NTR regulates axonogenesis	7	3.05e-01	4.46e-01	0.38500	-3.12e-01	2.26e-01	1.53e-01	3.01e-01
Synthesis of PIPs at the Golgi membrane	16	6.45e-02	1.46e-01	0.38500	2.16e-01	-3.19e-01	1.34e-01	2.73e-02
Generation of second messenger molecules	38	1.83e-04	1.01e-03	0.38500	5.68e-02	-3.81e-01	5.45e-01	4.91e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	2.60e-10	3.84e-09	0.38500	-3.75e-01	-8.73e-02	1.61e-08	1.88e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	4.06e-05	2.66e-04	0.38400	-3.84e-01	2.36e-02	1.69e-05	7.91e-01
HIV Transcription Elongation	42	4.06e-05	2.66e-04	0.38400	-3.84e-01	2.36e-02	1.69e-05	7.91e-01
Tat-mediated elongation of the HIV-1 transcript	42	4.06e-05	2.66e-04	0.38400	-3.84e-01	2.36e-02	1.69e-05	7.91e-01
Formation of Incision Complex in GG-NER	43	4.50e-05	2.93e-04	0.38400	-3.82e-01	4.03e-02	1.47e-05	6.48e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	7.69e-02	1.68e-01	0.38300	-3.74e-01	8.34e-02	2.47e-02	6.17e-01
tRNA processing	128	1.02e-13	2.70e-12	0.38300	-3.82e-01	3.53e-02	8.37e-14	4.91e-01
DNA Damage/Telomere Stress Induced Senescence	42	3.76e-04	1.94e-03	0.38300	-3.53e-01	1.48e-01	7.51e-05	9.59e-02
RNA Polymerase I Promoter Clearance	64	1.35e-06	1.08e-05	0.38200	-3.72e-01	8.37e-02	2.54e-07	2.47e-01
RNA Polymerase I Transcription	64	1.35e-06	1.08e-05	0.38200	-3.72e-01	8.37e-02	2.54e-07	2.47e-01
N-glycan trimming and elongation in the cis-Golgi	5	3.42e-01	4.85e-01	0.38100	-3.74e-01	7.51e-02	1.48e-01	7.71e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	1.00e-03	4.69e-03	0.38100	-3.81e-01	-1.78e-02	6.11e-04	8.73e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.00e-03	4.69e-03	0.38100	-3.81e-01	-1.78e-02	6.11e-04	8.73e-01
Signal transduction by L1	20	3.74e-02	9.78e-02	0.38100	-3.00e-01	2.35e-01	2.01e-02	6.89e-02
GABA synthesis, release, reuptake and degradation	12	5.97e-02	1.38e-01	0.38100	2.85e-02	-3.80e-01	8.64e-01	2.26e-02
Early Phase of HIV Life Cycle	14	9.91e-03	3.35e-02	0.38100	-3.06e-01	-2.26e-01	4.71e-02	1.42e-01
FCGR3A-mediated IL10 synthesis	99	1.12e-07	1.07e-06	0.38100	-2.48e-01	2.89e-01	1.98e-05	6.93e-07
Suppression of apoptosis	7	2.83e-01	4.25e-01	0.38000	-1.63e-01	3.44e-01	4.56e-01	1.15e-01
Purine catabolism	16	4.27e-02	1.06e-01	0.38000	-3.62e-01	1.14e-01	1.21e-02	4.29e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	2.56e-03	1.07e-02	0.38000	-3.72e-01	7.36e-02	6.46e-04	5.00e-01
Aryl hydrocarbon receptor signalling	6	1.50e-01	2.70e-01	0.38000	-3.34e-01	-1.80e-01	1.56e-01	4.46e-01
ER-Phagosome pathway	75	9.42e-07	7.81e-06	0.37900	-3.51e-01	1.43e-01	1.47e-07	3.19e-02
Fructose catabolism	5	1.93e-01	3.22e-01	0.37900	-2.59e-01	-2.76e-01	3.15e-01	2.85e-01
HIV elongation arrest and recovery	32	7.75e-04	3.73e-03	0.37800	-3.76e-01	4.54e-02	2.34e-04	6.57e-01
Pausing and recovery of HIV elongation	32	7.75e-04	3.73e-03	0.37800	-3.76e-01	4.54e-02	2.34e-04	6.57e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	7.71e-02	1.68e-01	0.37800	-2.49e-01	2.85e-01	8.51e-02	4.81e-02
Telomere C-strand (Lagging Strand) Synthesis	34	1.48e-05	1.02e-04	0.37800	-2.83e-01	-2.50e-01	4.26e-03	1.16e-02
Formation of Fibrin Clot (Clotting Cascade)	26	9.70e-03	3.28e-02	0.37800	-1.59e-01	3.42e-01	1.59e-01	2.52e-03
PCP/CE pathway	75	9.77e-07	8.07e-06	0.37700	-3.51e-01	1.37e-01	1.48e-07	4.04e-02
Olfactory Signaling Pathway	61	3.12e-09	3.74e-08	0.37600	2.25e-01	3.02e-01	2.42e-03	4.51e-05
Synthesis of 5-eicosatetraenoic acids	7	2.37e-01	3.75e-01	0.37500	-8.04e-02	3.67e-01	7.13e-01	9.29e-02
Activation of the phototransduction cascade	8	8.56e-02	1.81e-01	0.37500	1.70e-01	3.34e-01	4.05e-01	1.01e-01
Regulation of IFNA/IFNB signaling	12	1.42e-01	2.60e-01	0.37500	3.11e-01	-2.09e-01	6.21e-02	2.09e-01
Amine ligand-binding receptors	10	2.11e-01	3.42e-01	0.37400	2.67e-01	-2.63e-01	1.44e-01	1.51e-01
Scavenging by Class A Receptors	14	1.13e-01	2.24e-01	0.37400	-2.61e-01	2.68e-01	9.11e-02	8.25e-02
Diseases of programmed cell death	58	9.41e-06	6.71e-05	0.37400	-3.63e-01	8.88e-02	1.73e-06	2.42e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	1.15e-02	3.79e-02	0.37300	-3.69e-01	-5.78e-02	8.44e-03	6.80e-01
Signaling by FGFR4 in disease	11	8.21e-02	1.76e-01	0.37300	3.72e-01	-2.25e-02	3.25e-02	8.97e-01
Pyrimidine salvage	10	2.07e-01	3.38e-01	0.37300	-2.96e-01	2.27e-01	1.05e-01	2.14e-01
SARS-CoV-1-host interactions	95	6.43e-11	1.06e-09	0.37200	-3.72e-01	-2.57e-02	3.81e-10	6.65e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	1.12e-01	2.22e-01	0.37200	3.07e-01	2.11e-01	1.60e-01	3.34e-01
Interleukin-2 family signaling	38	1.34e-03	6.10e-03	0.37200	3.39e-01	-1.54e-01	3.02e-04	1.00e-01
mRNA Splicing	211	8.81e-24	3.62e-22	0.37200	-3.70e-01	-3.96e-02	1.82e-20	3.22e-01
Sulfur amino acid metabolism	23	2.39e-03	1.02e-02	0.37100	-3.65e-01	-6.59e-02	2.46e-03	5.84e-01
NR1H2 and NR1H3-mediated signaling	39	2.27e-03	9.67e-03	0.37100	2.21e-01	-2.98e-01	1.71e-02	1.30e-03
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	5.35e-05	3.38e-04	0.37000	-3.55e-01	1.05e-01	9.49e-06	1.90e-01
Azathioprine ADME	21	5.40e-03	2.03e-02	0.37000	-3.68e-01	-3.54e-02	3.48e-03	7.79e-01
Negative regulation of FGFR3 signaling	21	4.09e-02	1.03e-01	0.36900	-2.45e-01	2.76e-01	5.18e-02	2.85e-02
Signaling by activated point mutants of FGFR1	5	4.45e-01	5.83e-01	0.36900	-1.87e-01	3.18e-01	4.68e-01	2.18e-01
CREB3 factors activate genes	6	4.01e-01	5.45e-01	0.36900	-2.46e-01	2.76e-01	2.98e-01	2.42e-01
Sphingolipid de novo biosynthesis	34	5.56e-03	2.09e-02	0.36900	-2.37e-01	2.83e-01	1.68e-02	4.29e-03
Expression and translocation of olfactory receptors	56	2.80e-08	2.97e-07	0.36900	2.35e-01	2.85e-01	2.39e-03	2.28e-04
IkBA variant leads to EDA-ID	7	2.12e-01	3.44e-01	0.36900	3.68e-01	-2.31e-02	9.17e-02	9.16e-01
Glutathione synthesis and recycling	10	4.57e-02	1.12e-01	0.36800	-2.91e-01	-2.25e-01	1.11e-01	2.17e-01
Incretin synthesis, secretion, and inactivation	14	8.44e-02	1.80e-01	0.36800	-3.43e-01	1.33e-01	2.63e-02	3.88e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	8.44e-02	1.80e-01	0.36800	-3.43e-01	1.33e-01	2.63e-02	3.88e-01
RNA Polymerase III Transcription Initiation	36	6.18e-04	3.03e-03	0.36800	-3.63e-01	5.86e-02	1.63e-04	5.43e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	4.62e-08	4.80e-07	0.36800	-3.54e-01	-1.01e-01	1.45e-06	1.69e-01
G1/S Transition	120	1.93e-11	3.43e-10	0.36700	-3.63e-01	5.46e-02	6.23e-12	3.02e-01
Signaling by NOTCH4	70	4.46e-06	3.34e-05	0.36700	-3.43e-01	1.31e-01	7.02e-07	5.85e-02
TP53 Regulates Transcription of Caspase Activators and Caspases	12	1.65e-01	2.89e-01	0.36700	2.49e-01	-2.70e-01	1.36e-01	1.06e-01
Signaling by Erythropoietin	24	7.80e-03	2.74e-02	0.36600	3.61e-01	-6.22e-02	2.19e-03	5.98e-01
RUNX3 Regulates Immune Response and Cell Migration	6	2.30e-01	3.66e-01	0.36600	3.64e-01	3.72e-02	1.22e-01	8.75e-01
RAS processing	23	3.03e-02	8.25e-02	0.36600	-2.92e-01	2.21e-01	1.55e-02	6.59e-02
COPI-independent Golgi-to-ER retrograde traffic	45	1.19e-03	5.50e-03	0.36500	-2.36e-01	2.79e-01	6.13e-03	1.20e-03
DCC mediated attractive signaling	13	1.23e-01	2.38e-01	0.36500	-3.20e-01	1.75e-01	4.54e-02	2.73e-01
Anti-inflammatory response favouring Leishmania parasite infection	132	2.53e-09	3.16e-08	0.36500	-2.25e-01	2.88e-01	8.12e-06	1.14e-08
Leishmania parasite growth and survival	132	2.53e-09	3.16e-08	0.36500	-2.25e-01	2.88e-01	8.12e-06	1.14e-08
Dual incision in TC-NER	63	7.35e-08	7.28e-07	0.36500	-3.56e-01	-8.09e-02	1.02e-06	2.67e-01
Frs2-mediated activation	11	1.38e-01	2.55e-01	0.36400	-1.13e-01	3.46e-01	5.17e-01	4.66e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	4.46e-10	6.29e-09	0.36400	-3.57e-01	-7.29e-02	1.55e-08	2.48e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	9.12e-05	5.42e-04	0.36400	-3.63e-01	3.36e-02	3.14e-05	6.99e-01
mRNA Splicing - Major Pathway	203	5.82e-22	2.29e-20	0.36400	-3.61e-01	-4.00e-02	6.36e-19	3.26e-01
TRAF3-dependent IRF activation pathway	13	1.48e-01	2.68e-01	0.36300	2.60e-01	-2.54e-01	1.05e-01	1.12e-01
Vitamin C (ascorbate) metabolism	8	2.79e-01	4.23e-01	0.36300	3.20e-01	-1.70e-01	1.17e-01	4.06e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	8.33e-03	2.91e-02	0.36300	-2.92e-01	2.15e-01	4.27e-03	3.52e-02
Mitotic Telophase/Cytokinesis	13	1.11e-01	2.20e-01	0.36200	3.35e-01	-1.37e-01	3.63e-02	3.93e-01
RNA Polymerase III Abortive And Retractive Initiation	41	2.84e-04	1.50e-03	0.36200	-3.58e-01	5.69e-02	7.42e-05	5.29e-01
RNA Polymerase III Transcription	41	2.84e-04	1.50e-03	0.36200	-3.58e-01	5.69e-02	7.42e-05	5.29e-01
Initiation of Nuclear Envelope (NE) Reformation	19	5.80e-02	1.35e-01	0.36200	-2.94e-01	2.11e-01	2.65e-02	1.11e-01
Translesion Synthesis by POLH	18	1.40e-02	4.44e-02	0.36200	-3.60e-01	-3.33e-02	8.18e-03	8.07e-01
Crosslinking of collagen fibrils	15	1.50e-02	4.67e-02	0.36100	1.47e-01	3.30e-01	3.24e-01	2.69e-02
Metabolism of nucleotides	85	5.28e-09	6.11e-08	0.36100	-3.61e-01	-7.18e-03	8.96e-09	9.09e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	3.91e-03	1.56e-02	0.36100	-3.20e-01	1.67e-01	1.06e-03	8.73e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	6.42e-02	1.45e-01	0.36000	3.54e-01	6.75e-02	4.20e-02	6.98e-01
Nef Mediated CD8 Down-regulation	7	3.55e-01	4.98e-01	0.36000	-2.92e-01	2.11e-01	1.82e-01	3.33e-01
p75NTR negatively regulates cell cycle via SC1	5	3.08e-01	4.49e-01	0.36000	-3.58e-01	-3.41e-02	1.65e-01	8.95e-01
Cyclin A:Cdk2-associated events at S phase entry	75	5.66e-07	4.83e-06	0.36000	-3.53e-01	6.75e-02	1.22e-07	3.12e-01
Negative regulation of FGFR1 signaling	25	2.57e-02	7.29e-02	0.36000	-2.19e-01	2.85e-01	5.80e-02	1.36e-02
Cell surface interactions at the vascular wall	176	1.46e-11	2.65e-10	0.35800	-2.52e-01	2.54e-01	8.02e-09	5.71e-09
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	4.03e-03	1.59e-02	0.35800	-3.48e-01	8.37e-02	9.67e-04	4.28e-01
Wax and plasmalogen biosynthesis	5	3.56e-01	4.99e-01	0.35700	-3.56e-01	2.69e-02	1.68e-01	9.17e-01
Organic anion transporters	7	1.66e-01	2.89e-01	0.35700	-9.75e-02	-3.43e-01	6.55e-01	1.16e-01
NFE2L2 regulating tumorigenic genes	11	4.09e-02	1.03e-01	0.35600	2.74e-01	2.28e-01	1.16e-01	1.90e-01
Regulation of gene expression in beta cells	8	2.81e-01	4.23e-01	0.35600	3.23e-01	-1.51e-01	1.14e-01	4.58e-01
Nuclear events mediated by NFE2L2	82	3.70e-06	2.80e-05	0.35600	-3.12e-01	1.72e-01	1.02e-06	7.10e-03
Response of EIF2AK1 (HRI) to heme deficiency	14	1.26e-01	2.41e-01	0.35600	-3.00e-01	1.91e-01	5.18e-02	2.17e-01
Cellular hexose transport	14	4.86e-02	1.18e-01	0.35600	-1.54e-03	-3.56e-01	9.92e-01	2.13e-02
Polo-like kinase mediated events	16	9.19e-02	1.91e-01	0.35500	-3.05e-01	1.82e-01	3.47e-02	2.08e-01
Glycosphingolipid transport	7	1.54e-01	2.75e-01	0.35500	-1.35e-01	-3.28e-01	5.37e-01	1.32e-01
ABC-family proteins mediated transport	81	2.46e-06	1.90e-05	0.35500	-3.25e-01	1.41e-01	4.18e-07	2.80e-02
Netrin mediated repulsion signals	5	4.65e-01	6.00e-01	0.35400	1.64e-01	-3.14e-01	5.25e-01	2.24e-01
Pregnenolone biosynthesis	10	6.20e-02	1.42e-01	0.35400	-3.07e-01	-1.77e-01	9.28e-02	3.33e-01
Extension of Telomeres	51	4.56e-06	3.40e-05	0.35400	-3.48e-01	-6.72e-02	1.73e-05	4.06e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	2.38e-01	3.76e-01	0.35300	-2.50e-01	-2.50e-01	3.33e-01	3.34e-01
Neurexins and neuroligins	40	3.80e-03	1.53e-02	0.35300	2.64e-01	-2.34e-01	3.81e-03	1.03e-02
CD209 (DC-SIGN) signaling	20	5.70e-02	1.33e-01	0.35300	2.89e-01	-2.03e-01	2.53e-02	1.15e-01
PI-3K cascade:FGFR1	13	2.67e-02	7.50e-02	0.35300	1.88e-01	2.99e-01	2.40e-01	6.24e-02
Glycosphingolipid catabolism	31	5.76e-03	2.14e-02	0.35300	-3.33e-01	1.16e-01	1.32e-03	2.63e-01
Signaling by BMP	23	2.64e-02	7.45e-02	0.35300	3.23e-01	-1.41e-01	7.28e-03	2.43e-01
Cytochrome c-mediated apoptotic response	13	9.80e-02	2.00e-01	0.35200	-3.43e-01	8.11e-02	3.23e-02	6.13e-01
E3 ubiquitin ligases ubiquitinate target proteins	51	3.64e-04	1.88e-03	0.35200	-3.20e-01	1.47e-01	7.77e-05	6.92e-02
Interleukin-10 signaling	38	2.80e-03	1.16e-02	0.35100	3.19e-01	-1.48e-01	6.67e-04	1.15e-01
OAS antiviral response	8	1.36e-01	2.51e-01	0.35100	-9.84e-02	-3.37e-01	6.30e-01	9.86e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	4.85e-05	3.11e-04	0.35100	-3.25e-01	-1.34e-01	5.28e-04	1.54e-01
DNA Damage Reversal	8	1.54e-01	2.75e-01	0.35100	-3.46e-01	-5.75e-02	8.98e-02	7.78e-01
Maturation of spike protein 9694548	36	7.23e-03	2.56e-02	0.35100	-2.54e-01	2.42e-01	8.27e-03	1.21e-02
NFE2L2 regulating ER-stress associated genes	5	2.61e-01	4.04e-01	0.35000	3.11e-01	1.61e-01	2.29e-01	5.33e-01
Synthesis of 12-eicosatetraenoic acid derivatives	6	4.22e-01	5.64e-01	0.35000	-2.97e-01	1.85e-01	2.08e-01	4.32e-01
Lysosome Vesicle Biogenesis	32	4.36e-03	1.70e-02	0.35000	-3.36e-01	9.72e-02	9.98e-04	3.41e-01
Prolonged ERK activation events	13	8.68e-02	1.83e-01	0.34900	-4.89e-02	3.46e-01	7.60e-01	3.08e-02
Defective GALNT12 causes CRCS1	9	1.86e-01	3.13e-01	0.34900	3.45e-01	-5.06e-02	7.27e-02	7.93e-01
Myoclonic epilepsy of Lafora	8	3.02e-01	4.45e-01	0.34900	-3.12e-01	1.57e-01	1.27e-01	4.41e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	1.15e-02	3.80e-02	0.34900	-3.33e-01	-1.04e-01	1.46e-02	4.43e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.50e-02	7.11e-02	0.34800	-3.44e-01	5.41e-02	7.76e-03	6.75e-01
AKT phosphorylates targets in the nucleus	9	2.49e-01	3.89e-01	0.34800	1.37e-01	-3.20e-01	4.77e-01	9.68e-02
NF-kB is activated and signals survival	12	1.69e-01	2.92e-01	0.34800	-3.10e-01	1.57e-01	6.28e-02	3.46e-01
Paracetamol ADME	19	1.22e-02	3.96e-02	0.34700	-3.41e-01	-6.54e-02	1.00e-02	6.22e-01
RHO GTPases Activate Rhotekin and Rhophilins	8	2.95e-01	4.38e-01	0.34700	-3.17e-01	1.41e-01	1.20e-01	4.90e-01
NOTCH2 intracellular domain regulates transcription	11	1.72e-01	2.97e-01	0.34700	3.27e-01	-1.17e-01	6.07e-02	5.01e-01
Biotin transport and metabolism	11	5.01e-02	1.21e-01	0.34600	-2.04e-01	-2.80e-01	2.42e-01	1.08e-01
Xenobiotics	12	2.02e-01	3.32e-01	0.34600	2.30e-01	-2.58e-01	1.69e-01	1.21e-01
RUNX3 regulates p14-ARF	10	6.48e-02	1.46e-01	0.34500	2.36e-01	2.52e-01	1.97e-01	1.67e-01
Ribavirin ADME	11	9.27e-02	1.91e-01	0.34500	-3.43e-01	-3.30e-02	4.86e-02	8.50e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	9.42e-02	1.94e-01	0.34500	-3.41e-01	5.22e-02	3.33e-02	7.45e-01
Fc epsilon receptor (FCERI) signaling	179	6.55e-11	1.07e-09	0.34400	-2.52e-01	2.34e-01	5.58e-09	6.95e-08
Sema4D induced cell migration and growth-cone collapse	19	5.51e-02	1.31e-01	0.34300	-1.28e-01	3.19e-01	3.35e-01	1.62e-02
Inactivation, recovery and regulation of the phototransduction cascade	25	3.43e-02	9.16e-02	0.34200	-1.95e-01	2.82e-01	9.18e-02	1.48e-02
RHOBTB1 GTPase cycle	23	4.14e-02	1.04e-01	0.34200	-2.93e-01	1.76e-01	1.49e-02	1.43e-01
HIV Transcription Initiation	45	6.50e-05	3.98e-04	0.34200	-3.40e-01	-3.77e-02	7.97e-05	6.61e-01
RNA Polymerase II HIV Promoter Escape	45	6.50e-05	3.98e-04	0.34200	-3.40e-01	-3.77e-02	7.97e-05	6.61e-01
RNA Polymerase II Promoter Escape	45	6.50e-05	3.98e-04	0.34200	-3.40e-01	-3.77e-02	7.97e-05	6.61e-01
RNA Polymerase II Transcription Initiation	45	6.50e-05	3.98e-04	0.34200	-3.40e-01	-3.77e-02	7.97e-05	6.61e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	6.50e-05	3.98e-04	0.34200	-3.40e-01	-3.77e-02	7.97e-05	6.61e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	6.50e-05	3.98e-04	0.34200	-3.40e-01	-3.77e-02	7.97e-05	6.61e-01
Nuclear Receptor transcription pathway	40	4.63e-03	1.79e-02	0.34200	2.81e-01	-1.94e-01	2.08e-03	3.35e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	29	8.11e-03	2.84e-02	0.34200	-3.31e-01	8.43e-02	2.01e-03	4.32e-01
TGFBR3 regulates TGF-beta signaling	8	3.09e-01	4.50e-01	0.34200	1.42e-01	-3.11e-01	4.87e-01	1.28e-01
HDR through MMEJ (alt-NHEJ)	12	9.05e-02	1.89e-01	0.34100	-4.05e-03	-3.41e-01	9.81e-01	4.06e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.60e-02	4.95e-02	0.34100	-2.93e-01	1.75e-01	5.45e-03	9.80e-02
PI-3K cascade:FGFR3	10	6.99e-02	1.55e-01	0.34100	2.25e-01	2.56e-01	2.18e-01	1.61e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	2.43e-01	3.82e-01	0.34000	3.02e-01	-1.56e-01	9.77e-02	3.92e-01
Peroxisomal protein import	58	2.78e-06	2.14e-05	0.33900	-3.33e-01	-6.32e-02	1.13e-05	4.05e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	1.61e-01	2.83e-01	0.33900	-1.15e-01	3.19e-01	4.90e-01	5.60e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	3.02e-01	4.45e-01	0.33900	3.38e-01	1.05e-02	1.51e-01	9.65e-01
Positive epigenetic regulation of rRNA expression	60	1.03e-04	6.03e-04	0.33800	-3.20e-01	1.10e-01	1.82e-05	1.42e-01
ATF4 activates genes in response to endoplasmic reticulum stress	25	1.29e-02	4.14e-02	0.33800	-3.34e-01	5.21e-02	3.84e-03	6.52e-01
Phase 4 - resting membrane potential	9	3.05e-01	4.46e-01	0.33700	2.81e-01	-1.87e-01	1.44e-01	3.31e-01
Attachment of GPI anchor to uPAR	7	1.93e-01	3.22e-01	0.33700	-1.07e-01	-3.20e-01	6.23e-01	1.43e-01
Chaperone Mediated Autophagy	20	5.30e-02	1.26e-01	0.33700	-3.12e-01	1.27e-01	1.55e-02	3.27e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	3.53e-01	4.96e-01	0.33700	1.19e-01	-3.15e-01	5.85e-01	1.49e-01
Glycogen metabolism	21	6.13e-02	1.41e-01	0.33700	-1.78e-01	2.86e-01	1.59e-01	2.33e-02
Nef and signal transduction	8	2.47e-01	3.87e-01	0.33600	3.33e-01	-4.66e-02	1.03e-01	8.20e-01
Activation of the pre-replicative complex	32	1.56e-03	6.93e-03	0.33600	-3.36e-01	-2.33e-02	1.01e-03	8.19e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	5.83e-02	1.36e-01	0.33600	-2.93e-01	1.65e-01	2.02e-02	1.90e-01
Neurodegenerative Diseases	21	5.83e-02	1.36e-01	0.33600	-2.93e-01	1.65e-01	2.02e-02	1.90e-01
Heme signaling	45	1.55e-03	6.93e-03	0.33500	3.09e-01	-1.31e-01	3.38e-04	1.29e-01
Nucleotide Excision Repair	108	7.43e-11	1.20e-09	0.33500	-3.29e-01	-6.44e-02	3.42e-09	2.47e-01
Integration of provirus	9	1.00e-01	2.04e-01	0.33500	-2.69e-01	-2.01e-01	1.63e-01	2.97e-01
HDL assembly	6	3.18e-01	4.61e-01	0.33400	3.34e-01	4.24e-04	1.56e-01	9.99e-01
Organic cation transport	8	1.60e-01	2.82e-01	0.33400	1.03e-01	3.18e-01	6.14e-01	1.19e-01
Organic cation/anion/zwitterion transport	8	1.60e-01	2.82e-01	0.33400	1.03e-01	3.18e-01	6.14e-01	1.19e-01
Caspase activation via Death Receptors in the presence of ligand	16	1.32e-01	2.48e-01	0.33300	2.70e-01	-1.94e-01	6.14e-02	1.78e-01
Synthesis of PE	12	1.94e-01	3.23e-01	0.33300	-1.47e-01	2.98e-01	3.76e-01	7.35e-02
FGFR2 mutant receptor activation	23	1.08e-02	3.59e-02	0.33200	-3.32e-01	-2.23e-02	5.90e-03	8.53e-01
Amino acids regulate mTORC1	48	2.66e-03	1.11e-02	0.33100	-2.58e-01	2.08e-01	1.98e-03	1.26e-02
PI3K events in ERBB2 signaling	11	1.04e-01	2.11e-01	0.33100	3.28e-01	4.77e-02	5.98e-02	7.84e-01
Erythrocytes take up carbon dioxide and release oxygen	11	6.61e-02	1.49e-01	0.33100	1.89e-01	2.71e-01	2.78e-01	1.19e-01
O2/CO2 exchange in erythrocytes	11	6.61e-02	1.49e-01	0.33100	1.89e-01	2.71e-01	2.78e-01	1.19e-01
Fibronectin matrix formation	6	4.53e-01	5.89e-01	0.33000	-1.56e-01	2.91e-01	5.09e-01	2.17e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.24e-02	6.49e-02	0.33000	-3.14e-01	-1.02e-01	2.52e-02	4.65e-01
Cell Cycle Checkpoints	246	4.47e-16	1.37e-14	0.33000	-3.11e-01	1.09e-01	4.19e-17	3.24e-03
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	7	3.33e-01	4.74e-01	0.32900	3.21e-01	-7.29e-02	1.41e-01	7.38e-01
SHC-related events triggered by IGF1R	8	2.67e-01	4.10e-01	0.32900	3.25e-01	-5.17e-02	1.11e-01	8.00e-01
Transport of nucleotide sugars	9	2.45e-01	3.84e-01	0.32900	-3.21e-01	7.48e-02	9.57e-02	6.98e-01
Late endosomal microautophagy	30	1.02e-02	3.41e-02	0.32900	-3.18e-01	8.38e-02	2.55e-03	4.27e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.05e-24	4.49e-23	0.32900	-3.27e-01	-3.96e-02	5.48e-21	2.55e-01
Macroautophagy	128	3.11e-08	3.27e-07	0.32900	-2.99e-01	1.37e-01	5.30e-09	7.22e-03
Sema4D in semaphorin signaling	22	5.61e-02	1.32e-01	0.32800	-1.54e-01	2.90e-01	2.12e-01	1.84e-02
Diseases of Base Excision Repair	5	3.00e-01	4.44e-01	0.32800	-2.80e-01	-1.72e-01	2.78e-01	5.07e-01
RNA Polymerase II Transcription Termination	66	6.50e-06	4.77e-05	0.32800	-3.28e-01	5.94e-03	3.99e-06	9.33e-01
ABC transporters in lipid homeostasis	14	1.34e-01	2.50e-01	0.32700	3.10e-01	-1.06e-01	4.48e-02	4.92e-01
Branched-chain amino acid catabolism	21	2.00e-02	5.87e-02	0.32700	-3.27e-01	-1.13e-02	9.57e-03	9.28e-01
Mitotic G1 phase and G1/S transition	138	2.38e-10	3.53e-09	0.32700	-3.22e-01	5.39e-02	6.22e-11	2.74e-01
Diseases of Mismatch Repair (MMR)	5	4.60e-01	5.96e-01	0.32600	-3.19e-01	6.96e-02	2.17e-01	7.87e-01
Diseases associated with glycosylation precursor biosynthesis	15	1.20e-01	2.34e-01	0.32600	-3.07e-01	1.09e-01	3.96e-02	4.64e-01
Separation of Sister Chromatids	168	1.19e-10	1.83e-09	0.32600	-3.01e-01	1.23e-01	1.53e-11	5.77e-03
Sodium/Calcium exchangers	9	3.46e-01	4.89e-01	0.32600	-2.33e-01	2.28e-01	2.26e-01	2.37e-01
Transcription of the HIV genome	67	9.09e-06	6.50e-05	0.32600	-3.25e-01	1.85e-02	4.16e-06	7.93e-01
Telomere C-strand synthesis initiation	13	4.24e-02	1.06e-01	0.32600	-2.20e-01	-2.40e-01	1.69e-01	1.35e-01
Signaling by MST1	5	3.00e-01	4.44e-01	0.32500	-2.58e-01	-1.98e-01	3.17e-01	4.44e-01
Signaling by WNT in cancer	30	1.72e-03	7.56e-03	0.32400	3.12e-01	8.92e-02	3.10e-03	3.98e-01
UCH proteinases	73	2.65e-05	1.77e-04	0.32400	-3.10e-01	9.40e-02	4.52e-06	1.65e-01
Mitotic Anaphase	211	4.20e-13	1.01e-11	0.32400	-3.01e-01	1.21e-01	4.81e-14	2.48e-03
Mitotic Metaphase and Anaphase	212	4.30e-13	1.03e-11	0.32300	-3.00e-01	1.19e-01	4.86e-14	2.76e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	3.58e-02	9.43e-02	0.32300	2.97e-01	1.26e-01	4.64e-02	3.97e-01
SMAC (DIABLO) binds to IAPs	7	2.31e-01	3.67e-01	0.32300	-3.11e-01	-8.69e-02	1.55e-01	6.91e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	2.31e-01	3.67e-01	0.32300	-3.11e-01	-8.69e-02	1.55e-01	6.91e-01
SMAC, XIAP-regulated apoptotic response	7	2.31e-01	3.67e-01	0.32300	-3.11e-01	-8.69e-02	1.55e-01	6.91e-01
Retrograde neurotrophin signalling	12	1.92e-01	3.21e-01	0.32200	-3.03e-01	1.11e-01	6.95e-02	5.06e-01
RUNX3 regulates NOTCH signaling	14	4.50e-02	1.11e-01	0.32200	2.95e-01	1.28e-01	5.56e-02	4.06e-01
IL-6-type cytokine receptor ligand interactions	13	2.14e-01	3.46e-01	0.32200	2.61e-01	-1.88e-01	1.03e-01	2.40e-01
Unfolded Protein Response (UPR)	84	5.77e-05	3.61e-04	0.32200	-2.51e-01	2.01e-01	7.02e-05	1.44e-03
DNA Damage Bypass	47	5.31e-05	3.37e-04	0.32000	-3.05e-01	-9.71e-02	2.96e-04	2.50e-01
Activation of RAC1 downstream of NMDARs	7	4.45e-01	5.83e-01	0.32000	-2.52e-01	1.98e-01	2.49e-01	3.64e-01
Activation of AMPK downstream of NMDARs	20	7.73e-02	1.68e-01	0.32000	-1.35e-01	2.90e-01	2.97e-01	2.48e-02
Synaptic adhesion-like molecules	17	1.27e-01	2.43e-01	0.31900	2.76e-01	-1.61e-01	4.90e-02	2.51e-01
Na+/Cl- dependent neurotransmitter transporters	8	1.64e-01	2.87e-01	0.31900	1.63e-01	2.74e-01	4.26e-01	1.79e-01
S Phase	150	4.77e-12	9.50e-11	0.31800	-3.18e-01	-6.35e-03	1.77e-11	8.93e-01
Serotonin Neurotransmitter Release Cycle	15	1.72e-01	2.97e-01	0.31600	1.67e-01	-2.68e-01	2.63e-01	7.20e-02
Processing of Capped Intronless Pre-mRNA	29	8.17e-03	2.86e-02	0.31500	-3.15e-01	8.43e-03	3.34e-03	9.37e-01
Translation of Structural Proteins 9694635	56	2.09e-03	9.00e-03	0.31500	-2.26e-01	2.19e-01	3.37e-03	4.62e-03
RIP-mediated NFkB activation via ZBP1	17	1.54e-01	2.75e-01	0.31500	2.26e-01	-2.19e-01	1.07e-01	1.18e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	4.98e-02	1.20e-01	0.31400	-2.78e-01	1.47e-01	1.62e-02	2.02e-01
Fcgamma receptor (FCGR) dependent phagocytosis	147	1.08e-07	1.04e-06	0.31400	-2.12e-01	2.31e-01	8.79e-06	1.34e-06
Nuclear Envelope (NE) Reassembly	68	2.21e-04	1.20e-03	0.31300	-2.86e-01	1.27e-01	4.46e-05	7.08e-02
Downstream signaling events of B Cell Receptor (BCR)	68	2.06e-04	1.14e-03	0.31300	-2.88e-01	1.22e-01	4.02e-05	8.31e-02
Metabolism of non-coding RNA	53	1.25e-05	8.78e-05	0.31200	-2.76e-01	-1.45e-01	4.97e-04	6.85e-02
snRNP Assembly	53	1.25e-05	8.78e-05	0.31200	-2.76e-01	-1.45e-01	4.97e-04	6.85e-02
HIV Infection	213	4.28e-15	1.20e-13	0.31100	-3.10e-01	2.37e-02	5.49e-15	5.50e-01
Activation of Ca-permeable Kainate Receptor	9	1.58e-01	2.80e-01	0.31100	2.88e-01	1.17e-01	1.34e-01	5.44e-01
Ionotropic activity of kainate receptors	9	1.58e-01	2.80e-01	0.31100	2.88e-01	1.17e-01	1.34e-01	5.44e-01
Protein ubiquitination	71	2.45e-04	1.32e-03	0.31000	-2.75e-01	1.43e-01	6.05e-05	3.75e-02
Golgi Associated Vesicle Biogenesis	55	2.84e-03	1.17e-02	0.31000	-2.20e-01	2.18e-01	4.78e-03	5.12e-03
Metabolism of nitric oxide: NOS3 activation and regulation	15	1.28e-01	2.44e-01	0.30900	-3.00e-01	7.35e-02	4.40e-02	6.22e-01
H139Hfs13* PPM1K causes a mild variant of MSUD	5	5.88e-01	7.00e-01	0.30900	-2.23e-01	2.14e-01	3.89e-01	4.07e-01
Maple Syrup Urine Disease	5	5.88e-01	7.00e-01	0.30900	-2.23e-01	2.14e-01	3.89e-01	4.07e-01
Protein folding	83	6.93e-05	4.22e-04	0.30800	-2.73e-01	1.42e-01	1.67e-05	2.54e-02
TNFR1-induced proapoptotic signaling	24	7.52e-02	1.65e-01	0.30700	2.48e-01	-1.81e-01	3.53e-02	1.24e-01
Heme biosynthesis	13	8.17e-02	1.76e-01	0.30700	-9.12e-02	-2.94e-01	5.69e-01	6.69e-02
Calnexin/calreticulin cycle	26	6.12e-02	1.41e-01	0.30700	-2.47e-01	1.83e-01	2.93e-02	1.06e-01
Transcriptional regulation of pluripotent stem cells	21	1.65e-02	5.05e-02	0.30700	2.90e-01	1.01e-01	2.13e-02	4.24e-01
Autophagy	142	5.57e-08	5.66e-07	0.30700	-2.79e-01	1.29e-01	9.69e-09	7.88e-03
ZBP1(DAI) mediated induction of type I IFNs	20	1.20e-01	2.34e-01	0.30700	2.39e-01	-1.93e-01	6.43e-02	1.36e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	6.29e-03	2.29e-02	0.30700	-2.37e-01	1.95e-01	4.54e-03	1.93e-02
Negative regulation of FGFR4 signaling	22	9.99e-02	2.03e-01	0.30700	-2.13e-01	2.21e-01	8.41e-02	7.28e-02
Host Interactions of HIV factors	118	1.61e-08	1.76e-07	0.30700	-3.06e-01	2.11e-02	9.28e-09	6.93e-01
Recycling pathway of L1	40	1.52e-02	4.74e-02	0.30700	-2.10e-01	2.23e-01	2.14e-02	1.46e-02
Beta-oxidation of pristanoyl-CoA	9	1.85e-01	3.13e-01	0.30600	-2.96e-01	-7.88e-02	1.24e-01	6.82e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	2.16e-01	3.49e-01	0.30600	-3.04e-01	-3.01e-02	1.14e-01	8.76e-01
NFE2L2 regulating MDR associated enzymes	8	1.80e-01	3.05e-01	0.30600	2.31e-01	2.01e-01	2.58e-01	3.26e-01
Germ layer formation at gastrulation	9	2.04e-01	3.35e-01	0.30600	3.02e-01	4.76e-02	1.17e-01	8.05e-01
trans-Golgi Network Vesicle Budding	69	5.86e-04	2.89e-03	0.30600	-2.54e-01	1.71e-01	2.67e-04	1.43e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	6.82e-02	1.52e-01	0.30600	-3.06e-01	3.38e-03	2.91e-02	9.81e-01
Nucleotide catabolism	28	2.32e-02	6.66e-02	0.30500	-2.97e-01	6.91e-02	6.45e-03	5.27e-01
HSF1 activation	26	4.09e-03	1.62e-02	0.30500	-2.44e-01	-1.83e-01	3.13e-02	1.06e-01
SARS-CoV-1 Infection	138	4.28e-10	6.07e-09	0.30500	-3.05e-01	4.39e-03	6.00e-10	9.29e-01
ADP signalling through P2Y purinoceptor 12	18	1.34e-01	2.50e-01	0.30300	-1.42e-01	2.68e-01	2.98e-01	4.89e-02
HCMV Late Events	67	2.52e-04	1.35e-03	0.30300	-2.88e-01	9.57e-02	4.69e-05	1.75e-01
Cell-extracellular matrix interactions	16	1.92e-01	3.21e-01	0.30300	-1.89e-01	2.36e-01	1.91e-01	1.01e-01
O-glycosylation of TSR domain-containing proteins	28	1.53e-02	4.76e-02	0.30200	3.02e-01	-1.73e-02	5.75e-03	8.74e-01
Formation of paraxial mesoderm	52	1.78e-03	7.74e-03	0.30200	-2.85e-01	9.77e-02	3.72e-04	2.23e-01
Platelet activation, signaling and aggregation	223	1.65e-10	2.50e-09	0.30200	-1.95e-01	2.30e-01	4.90e-07	3.39e-09
Glycogen breakdown (glycogenolysis)	12	1.33e-01	2.50e-01	0.30100	3.83e-02	2.98e-01	8.18e-01	7.34e-02
Antimicrobial peptides	34	1.78e-02	5.38e-02	0.30100	-1.07e-01	2.81e-01	2.79e-01	4.56e-03
Ca2+ activated K+ channels	6	5.36e-01	6.63e-01	0.29900	-2.50e-01	1.65e-01	2.90e-01	4.83e-01
KEAP1-NFE2L2 pathway	107	1.43e-05	9.92e-05	0.29900	-2.53e-01	1.59e-01	6.10e-06	4.45e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	2.01e-01	3.31e-01	0.29900	-2.31e-01	1.90e-01	1.10e-01	1.89e-01
Synthesis of PC	23	9.31e-02	1.92e-01	0.29800	-1.64e-01	2.49e-01	1.73e-01	3.86e-02
Defective B3GALTL causes PpS	27	1.72e-02	5.21e-02	0.29800	2.98e-01	-1.91e-03	7.37e-03	9.86e-01
Transcriptional regulation of testis differentiation	5	5.40e-01	6.66e-01	0.29800	2.86e-01	-8.30e-02	2.68e-01	7.48e-01
Other interleukin signaling	19	1.49e-01	2.70e-01	0.29800	1.85e-01	-2.33e-01	1.63e-01	7.81e-02
Regulation of innate immune responses to cytosolic DNA	14	8.26e-02	1.77e-01	0.29800	-2.87e-01	-7.98e-02	6.31e-02	6.05e-01
mTORC1-mediated signalling	24	5.72e-02	1.33e-01	0.29800	-2.82e-01	9.47e-02	1.67e-02	4.22e-01
E2F-enabled inhibition of pre-replication complex formation	9	3.19e-01	4.61e-01	0.29700	-2.89e-01	6.74e-02	1.33e-01	7.26e-01
Synthesis of 15-eicosatetraenoic acid derivatives	6	5.27e-01	6.54e-01	0.29600	-2.63e-01	1.36e-01	2.65e-01	5.64e-01
CASP8 activity is inhibited	11	3.28e-01	4.69e-01	0.29500	2.48e-01	-1.60e-01	1.55e-01	3.57e-01
Dimerization of procaspase-8	11	3.28e-01	4.69e-01	0.29500	2.48e-01	-1.60e-01	1.55e-01	3.57e-01
Regulation by c-FLIP	11	3.28e-01	4.69e-01	0.29500	2.48e-01	-1.60e-01	1.55e-01	3.57e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	30	5.47e-02	1.30e-01	0.29500	-2.20e-01	1.96e-01	3.67e-02	6.37e-02
Cell-cell junction organization	60	2.78e-03	1.15e-02	0.29400	2.34e-01	-1.78e-01	1.68e-03	1.72e-02
Reversal of alkylation damage by DNA dioxygenases	7	3.67e-01	5.08e-01	0.29400	-2.93e-01	1.03e-02	1.79e-01	9.62e-01
Activation of caspases through apoptosome-mediated cleavage	6	3.84e-01	5.27e-01	0.29400	-2.91e-01	-3.69e-02	2.17e-01	8.76e-01
Defects in vitamin and cofactor metabolism	21	1.86e-02	5.52e-02	0.29300	-1.41e-01	-2.57e-01	2.63e-01	4.13e-02
ARMS-mediated activation	6	3.71e-01	5.12e-01	0.29300	5.45e-02	2.88e-01	8.17e-01	2.21e-01
Phase 2 - plateau phase	11	3.49e-01	4.91e-01	0.29300	2.03e-01	-2.12e-01	2.44e-01	2.24e-01
Assembly Of The HIV Virion	15	1.75e-01	3.00e-01	0.29300	-2.78e-01	9.23e-02	6.21e-02	5.36e-01
Nuclear events stimulated by ALK signaling in cancer	33	4.14e-02	1.04e-01	0.29300	1.86e-01	-2.27e-01	6.45e-02	2.43e-02
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	4.68e-01	6.03e-01	0.29300	5.82e-02	-2.87e-01	8.05e-01	2.23e-01
Regulation of BACH1 activity	11	2.25e-01	3.61e-01	0.29300	-2.91e-01	3.08e-02	9.44e-02	8.60e-01
Diseases associated with the TLR signaling cascade	29	4.39e-02	1.09e-01	0.29300	2.67e-01	-1.21e-01	1.30e-02	2.59e-01
Diseases of Immune System	29	4.39e-02	1.09e-01	0.29300	2.67e-01	-1.21e-01	1.30e-02	2.59e-01
Antigen processing-Cross presentation	89	4.96e-05	3.18e-04	0.29300	-2.73e-01	1.06e-01	8.68e-06	8.36e-02
MyD88 deficiency (TLR2/4)	14	1.89e-01	3.17e-01	0.29200	2.81e-01	-8.07e-02	6.86e-02	6.01e-01
Regulation of PTEN mRNA translation	13	2.12e-01	3.44e-01	0.29200	2.81e-01	-7.80e-02	7.89e-02	6.26e-01
Common Pathway of Fibrin Clot Formation	13	1.37e-01	2.53e-01	0.29200	2.34e-02	2.91e-01	8.84e-01	6.94e-02
Basigin interactions	23	1.12e-01	2.22e-01	0.29100	-2.27e-01	1.81e-01	5.94e-02	1.32e-01
Defective Intrinsic Pathway for Apoptosis	24	6.90e-02	1.54e-01	0.29000	-2.73e-01	9.98e-02	2.08e-02	3.97e-01
TRP channels	22	8.21e-02	1.76e-01	0.29000	2.75e-01	-9.15e-02	2.54e-02	4.58e-01
Activation of RAS in B cells	5	5.44e-01	6.68e-01	0.29000	2.83e-01	-6.44e-02	2.74e-01	8.03e-01
IRE1alpha activates chaperones	46	1.17e-02	3.86e-02	0.28900	-1.62e-01	2.40e-01	5.76e-02	4.88e-03
Regulation of FOXO transcriptional activity by acetylation	10	1.75e-01	3.00e-01	0.28900	9.95e-02	2.72e-01	5.86e-01	1.37e-01
CLEC7A/inflammasome pathway	6	5.72e-01	6.87e-01	0.28900	2.08e-01	-2.01e-01	3.78e-01	3.94e-01
Role of second messengers in netrin-1 signaling	6	5.62e-01	6.80e-01	0.28900	2.39e-01	-1.62e-01	3.12e-01	4.91e-01
Linoleic acid (LA) metabolism	7	5.18e-01	6.46e-01	0.28900	2.26e-01	-1.80e-01	3.01e-01	4.10e-01
Gluconeogenesis	19	2.74e-02	7.66e-02	0.28800	-2.29e-01	-1.75e-01	8.33e-02	1.87e-01
Voltage gated Potassium channels	26	4.96e-02	1.20e-01	0.28800	2.77e-01	-7.83e-02	1.45e-02	4.89e-01
PI-3K cascade:FGFR4	11	1.32e-01	2.48e-01	0.28800	2.47e-01	1.48e-01	1.56e-01	3.97e-01
Acetylcholine binding and downstream events	5	4.42e-01	5.82e-01	0.28800	2.80e-01	6.72e-02	2.79e-01	7.95e-01
Postsynaptic nicotinic acetylcholine receptors	5	4.42e-01	5.82e-01	0.28800	2.80e-01	6.72e-02	2.79e-01	7.95e-01
Interaction between L1 and Ankyrins	26	4.11e-02	1.03e-01	0.28700	2.82e-01	-5.23e-02	1.28e-02	6.45e-01
MECP2 regulates neuronal receptors and channels	14	2.21e-01	3.55e-01	0.28700	2.68e-01	-1.02e-01	8.23e-02	5.10e-01
Viral Infection Pathways	776	7.87e-41	5.43e-39	0.28600	-2.82e-01	5.10e-02	7.78e-41	1.56e-02
Transcriptional regulation by small RNAs	61	5.03e-04	2.49e-03	0.28600	-2.83e-01	4.34e-02	1.35e-04	5.58e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.80e-01	3.05e-01	0.28500	-2.81e-01	4.84e-02	6.87e-02	7.54e-01
Degradation of beta-catenin by the destruction complex	72	4.42e-04	2.24e-03	0.28500	-2.68e-01	9.78e-02	8.50e-05	1.51e-01
Membrane binding and targetting of GAG proteins	13	1.68e-01	2.91e-01	0.28500	-2.85e-01	3.46e-03	7.51e-02	9.83e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	1.68e-01	2.91e-01	0.28500	-2.85e-01	3.46e-03	7.51e-02	9.83e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	3.30e-02	8.88e-02	0.28500	2.85e-01	-5.12e-03	1.37e-02	9.65e-01
RHOBTB GTPase Cycle	35	3.71e-02	9.74e-02	0.28400	-2.40e-01	1.52e-01	1.42e-02	1.19e-01
Late Phase of HIV Life Cycle	131	1.62e-08	1.76e-07	0.28400	-2.84e-01	-7.94e-04	2.00e-08	9.87e-01
Cellular responses to stress	698	1.75e-34	8.90e-33	0.28400	-2.75e-01	6.93e-02	2.47e-35	1.81e-03
Purine salvage	12	1.10e-01	2.20e-01	0.28300	-2.14e-01	-1.86e-01	2.00e-01	2.65e-01
Phase II - Conjugation of compounds	71	4.99e-04	2.48e-03	0.28300	-2.68e-01	9.23e-02	9.63e-05	1.79e-01
HIV Life Cycle	144	9.65e-10	1.30e-08	0.28300	-2.82e-01	-2.60e-02	5.41e-09	5.90e-01
Butyrophilin (BTN) family interactions	9	3.85e-01	5.29e-01	0.28300	9.62e-02	-2.66e-01	6.17e-01	1.67e-01
The phototransduction cascade	26	9.04e-02	1.89e-01	0.28200	-1.56e-01	2.35e-01	1.68e-01	3.77e-02
Chondroitin sulfate biosynthesis	12	1.22e-01	2.35e-01	0.28200	2.48e-01	1.35e-01	1.37e-01	4.19e-01
IFNG signaling activates MAPKs	8	3.57e-01	4.99e-01	0.28200	-2.14e-02	2.82e-01	9.16e-01	1.68e-01
Signaling by high-kinase activity BRAF mutants	33	4.90e-02	1.19e-01	0.28200	-2.31e-01	1.63e-01	2.17e-02	1.06e-01
Cholesterol biosynthesis	26	4.02e-02	1.03e-01	0.28200	-2.80e-01	3.55e-02	1.36e-02	7.54e-01
N-glycan antennae elongation in the medial/trans-Golgi	21	1.57e-01	2.79e-01	0.28200	-1.92e-01	2.06e-01	1.28e-01	1.02e-01
MAP2K and MAPK activation	36	3.56e-02	9.37e-02	0.28100	-2.38e-01	1.50e-01	1.34e-02	1.19e-01
Non-integrin membrane-ECM interactions	51	2.68e-03	1.12e-02	0.28100	-5.69e-02	2.75e-01	4.82e-01	6.65e-04
mRNA 3’-end processing	57	8.30e-04	3.96e-03	0.27900	-2.78e-01	2.53e-02	2.79e-04	7.41e-01
Suppression of phagosomal maturation	12	2.98e-01	4.41e-01	0.27900	-2.59e-01	1.04e-01	1.20e-01	5.32e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.66e-01	4.08e-01	0.27900	-2.47e-01	1.30e-01	1.10e-01	3.98e-01
Signaling by NODAL	15	2.49e-01	3.89e-01	0.27900	-1.40e-01	2.41e-01	3.48e-01	1.06e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	4.24e-03	1.66e-02	0.27900	2.78e-01	-2.50e-02	1.43e-03	7.74e-01
CLEC7A (Dectin-1) induces NFAT activation	11	3.33e-01	4.74e-01	0.27900	2.58e-01	-1.07e-01	1.39e-01	5.40e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.24e-01	2.39e-01	0.27800	-2.35e-01	1.48e-01	5.06e-02	2.18e-01
Prostacyclin signalling through prostacyclin receptor	16	2.47e-01	3.87e-01	0.27800	-2.18e-01	1.73e-01	1.31e-01	2.32e-01
Processing of DNA double-strand break ends	69	4.61e-04	2.33e-03	0.27800	-2.71e-01	6.25e-02	1.00e-04	3.69e-01
Transport of vitamins, nucleosides, and related molecules	32	2.31e-02	6.64e-02	0.27800	-2.75e-01	4.19e-02	7.18e-03	6.82e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	8.15e-02	1.76e-01	0.27700	-2.77e-01	1.74e-02	3.21e-02	8.93e-01
Chaperonin-mediated protein folding	77	8.20e-04	3.92e-03	0.27700	-2.43e-01	1.33e-01	2.28e-04	4.32e-02
Interleukin-23 signaling	7	5.49e-01	6.71e-01	0.27700	2.07e-01	-1.84e-01	3.43e-01	3.99e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	5	4.18e-01	5.60e-01	0.27600	1.77e-01	2.12e-01	4.93e-01	4.12e-01
TRAIL signaling	8	3.63e-01	5.05e-01	0.27600	2.76e-01	-1.07e-02	1.76e-01	9.58e-01
Dermatan sulfate biosynthesis	6	5.52e-01	6.74e-01	0.27600	-1.02e-01	2.57e-01	6.66e-01	2.76e-01
XBP1(S) activates chaperone genes	44	2.37e-02	6.79e-02	0.27600	-1.78e-01	2.10e-01	4.06e-02	1.59e-02
Integrin signaling	22	1.43e-01	2.61e-01	0.27500	-1.49e-01	2.31e-01	2.25e-01	6.04e-02
G alpha (z) signalling events	36	8.55e-03	2.97e-02	0.27500	1.07e-02	2.75e-01	9.12e-01	4.32e-03
Transcriptional Regulation by NPAS4	27	4.07e-02	1.03e-01	0.27500	2.73e-01	-3.16e-02	1.40e-02	7.76e-01
Late SARS-CoV-2 Infection Events	64	4.66e-03	1.79e-02	0.27500	-1.97e-01	1.91e-01	6.34e-03	8.11e-03
Glyoxylate metabolism and glycine degradation	13	2.57e-01	3.98e-01	0.27400	-2.63e-01	7.45e-02	1.00e-01	6.42e-01
Response of Mtb to phagocytosis	22	1.62e-01	2.84e-01	0.27300	-1.95e-01	1.91e-01	1.14e-01	1.21e-01
HCMV Infection	106	2.27e-05	1.55e-04	0.27200	-2.60e-01	8.17e-02	3.81e-06	1.46e-01
Cytosolic sulfonation of small molecules	18	2.24e-01	3.60e-01	0.27200	-1.71e-01	2.11e-01	2.08e-01	1.22e-01
Cobalamin (Cbl) metabolism	7	4.28e-01	5.70e-01	0.27200	1.40e-02	-2.71e-01	9.49e-01	2.14e-01
SHC1 events in ERBB4 signaling	10	4.15e-01	5.58e-01	0.27200	2.35e-01	-1.36e-01	1.98e-01	4.57e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	4.55e-01	5.90e-01	0.27100	2.56e-01	-8.91e-02	2.09e-01	6.63e-01
Glycogen storage diseases	13	3.46e-01	4.89e-01	0.27100	-1.94e-01	1.89e-01	2.25e-01	2.38e-01
Defective C1GALT1C1 causes TNPS	10	3.14e-01	4.55e-01	0.27000	2.69e-01	-2.76e-02	1.41e-01	8.80e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	3.53e-06	2.69e-05	0.27000	-2.69e-01	8.23e-03	2.06e-06	8.85e-01
EGFR interacts with phospholipase C-gamma	7	4.38e-01	5.79e-01	0.26900	2.69e-01	-1.78e-02	2.18e-01	9.35e-01
Reelin signalling pathway	5	4.88e-01	6.18e-01	0.26900	6.51e-02	2.61e-01	8.01e-01	3.12e-01
Repression of WNT target genes	14	3.21e-01	4.63e-01	0.26900	2.04e-01	-1.75e-01	1.85e-01	2.57e-01
Formation of apoptosome	11	3.04e-01	4.46e-01	0.26900	-2.65e-01	4.78e-02	1.29e-01	7.84e-01
Regulation of the apoptosome activity	11	3.04e-01	4.46e-01	0.26900	-2.65e-01	4.78e-02	1.29e-01	7.84e-01
Phosphorylation of Emi1	6	5.60e-01	6.79e-01	0.26900	-2.54e-01	8.83e-02	2.82e-01	7.08e-01
Regulation of beta-cell development	22	6.38e-02	1.45e-01	0.26900	2.69e-01	6.81e-03	2.92e-02	9.56e-01
tRNA processing in the nucleus	59	1.54e-04	8.67e-04	0.26800	-2.53e-01	-8.85e-02	7.72e-04	2.40e-01
Cellular responses to stimuli	779	7.74e-33	3.83e-31	0.26800	-2.56e-01	8.05e-02	5.49e-34	1.32e-04
Methylation	13	2.91e-01	4.35e-01	0.26800	-2.52e-01	9.14e-02	1.16e-01	5.68e-01
G2/M DNA damage checkpoint	66	2.49e-03	1.05e-02	0.26800	-2.45e-01	1.07e-01	5.67e-04	1.31e-01
Synthesis of PG	8	4.52e-01	5.89e-01	0.26800	7.54e-02	-2.57e-01	7.12e-01	2.09e-01
Metabolism of porphyrins	23	3.51e-02	9.27e-02	0.26800	-2.56e-01	-7.84e-02	3.37e-02	5.15e-01
TRAF6 mediated IRF7 activation	15	2.95e-01	4.38e-01	0.26700	2.14e-01	-1.60e-01	1.51e-01	2.83e-01
GAB1 signalosome	15	9.00e-02	1.89e-01	0.26700	2.23e-01	1.47e-01	1.35e-01	3.23e-01
Maternal to zygotic transition (MZT)	72	1.92e-03	8.31e-03	0.26700	-1.21e-01	2.37e-01	7.51e-02	4.93e-04
Reversible hydration of carbon dioxide	8	2.74e-01	4.18e-01	0.26700	1.65e-01	2.09e-01	4.18e-01	3.06e-01
TP53 Regulates Metabolic Genes	78	1.47e-03	6.61e-03	0.26600	-2.28e-01	1.37e-01	4.87e-04	3.68e-02
Diseases of carbohydrate metabolism	29	8.02e-02	1.74e-01	0.26600	-2.38e-01	1.19e-01	2.66e-02	2.69e-01
Synthesis of PIPs at the plasma membrane	52	3.03e-03	1.25e-02	0.26600	2.64e-01	-2.78e-02	9.75e-04	7.29e-01
Regulation of TP53 Activity through Association with Co-factors	13	3.57e-01	4.99e-01	0.26500	2.06e-01	-1.67e-01	1.98e-01	2.99e-01
Homology Directed Repair	110	1.16e-06	9.36e-06	0.26500	-2.64e-01	-1.68e-02	1.67e-06	7.61e-01
Vitamin B2 (riboflavin) metabolism	6	4.25e-01	5.67e-01	0.26500	-7.75e-02	-2.53e-01	7.42e-01	2.83e-01
IRAK4 deficiency (TLR2/4)	15	2.25e-01	3.60e-01	0.26400	2.56e-01	-6.48e-02	8.55e-02	6.64e-01
TRIF-mediated programmed cell death	9	4.97e-01	6.26e-01	0.26400	1.88e-01	-1.85e-01	3.28e-01	3.36e-01
Diseases associated with O-glycosylation of proteins	50	1.12e-02	3.73e-02	0.26400	2.44e-01	-9.99e-02	2.79e-03	2.22e-01
Pyrimidine catabolism	9	4.97e-01	6.26e-01	0.26300	-2.00e-01	1.71e-01	2.98e-01	3.75e-01
Interleukin-37 signaling	19	5.87e-02	1.36e-01	0.26300	2.38e-01	1.11e-01	7.21e-02	4.01e-01
PTK6 promotes HIF1A stabilization	6	4.36e-01	5.78e-01	0.26300	2.54e-01	6.81e-02	2.82e-01	7.73e-01
RHO GTPases Activate ROCKs	18	1.34e-01	2.50e-01	0.26300	-1.94e-02	2.62e-01	8.86e-01	5.42e-02
Lysosphingolipid and LPA receptors	11	4.10e-01	5.54e-01	0.26300	2.24e-01	-1.38e-01	1.99e-01	4.29e-01
EGFR downregulation	27	7.06e-02	1.56e-01	0.26300	-6.41e-02	2.55e-01	5.65e-01	2.20e-02
Phase 3 - rapid repolarisation	6	5.49e-01	6.71e-01	0.26300	5.77e-02	-2.56e-01	8.07e-01	2.77e-01
Metabolism of proteins	1777	4.35e-73	2.80e-70	0.26200	-2.57e-01	5.32e-02	7.45e-73	1.97e-04
Leishmania infection	211	1.07e-07	1.04e-06	0.26200	-1.75e-01	1.95e-01	1.15e-05	1.04e-06
Parasitic Infection Pathways	211	1.07e-07	1.04e-06	0.26200	-1.75e-01	1.95e-01	1.15e-05	1.04e-06
Regulation of TLR by endogenous ligand	15	2.88e-01	4.32e-01	0.26100	1.23e-01	-2.31e-01	4.11e-01	1.22e-01
Other semaphorin interactions	16	8.36e-02	1.79e-01	0.26100	2.09e-01	1.57e-01	1.49e-01	2.76e-01
MAPK6/MAPK4 signaling	69	1.58e-03	7.00e-03	0.26100	-2.50e-01	7.61e-02	3.32e-04	2.74e-01
Signaling by ERBB2 KD Mutants	20	1.49e-01	2.69e-01	0.26100	2.51e-01	-6.92e-02	5.15e-02	5.92e-01
p75NTR signals via NF-kB	15	2.64e-01	4.07e-01	0.26100	-2.43e-01	9.40e-02	1.03e-01	5.28e-01
G beta:gamma signalling through BTK	15	3.11e-01	4.52e-01	0.26000	-1.48e-01	2.14e-01	3.21e-01	1.51e-01
SOS-mediated signalling	7	4.04e-01	5.49e-01	0.26000	4.64e-02	2.56e-01	8.32e-01	2.41e-01
Protein-protein interactions at synapses	61	8.60e-03	2.98e-02	0.26000	2.16e-01	-1.45e-01	3.57e-03	5.02e-02
Metabolic disorders of biological oxidation enzymes	26	1.42e-01	2.60e-01	0.25900	-1.69e-01	1.96e-01	1.36e-01	8.29e-02
RNA Polymerase I Transcription Initiation	47	1.15e-03	5.35e-03	0.25900	-2.35e-01	-1.08e-01	5.28e-03	2.01e-01
Downstream signaling of activated FGFR1	22	3.98e-02	1.02e-01	0.25900	2.29e-01	1.20e-01	6.26e-02	3.31e-01
Transcriptional regulation of granulopoiesis	44	3.05e-02	8.29e-02	0.25800	-1.28e-01	2.24e-01	1.42e-01	1.02e-02
Mitotic Spindle Checkpoint	108	9.25e-05	5.47e-04	0.25800	-2.40e-01	9.42e-02	1.67e-05	9.07e-02
Transcriptional regulation by RUNX2	92	1.45e-04	8.24e-04	0.25800	-2.51e-01	5.59e-02	3.07e-05	3.54e-01
Association of TriC/CCT with target proteins during biosynthesis	35	2.85e-02	7.91e-02	0.25700	-2.55e-01	3.70e-02	9.12e-03	7.05e-01
HDR through Homologous Recombination (HRR)	68	1.22e-04	7.03e-04	0.25700	-2.48e-01	-6.83e-02	4.05e-04	3.30e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	1.42e-01	2.60e-01	0.25700	2.37e-01	9.72e-02	1.24e-01	5.29e-01
RHO GTPases Activate WASPs and WAVEs	35	7.71e-02	1.68e-01	0.25700	-1.75e-01	1.87e-01	7.29e-02	5.50e-02
Signaling by NTRK3 (TRKC)	16	2.43e-01	3.82e-01	0.25600	2.43e-01	-8.23e-02	9.27e-02	5.69e-01
MicroRNA (miRNA) biogenesis	24	1.00e-01	2.03e-01	0.25600	-2.50e-01	5.34e-02	3.37e-02	6.51e-01
Regulation of signaling by CBL	22	9.06e-02	1.89e-01	0.25600	2.56e-01	-8.25e-03	3.77e-02	9.47e-01
MET promotes cell motility	33	4.72e-02	1.15e-01	0.25600	-6.41e-02	2.47e-01	5.24e-01	1.39e-02
Regulation of HMOX1 expression and activity	5	6.58e-01	7.65e-01	0.25600	2.36e-01	-9.89e-02	3.61e-01	7.02e-01
SUMOylation of DNA methylation proteins	16	9.12e-02	1.90e-01	0.25500	-1.89e-01	-1.72e-01	1.91e-01	2.34e-01
MET activates RAS signaling	10	2.29e-01	3.64e-01	0.25500	2.08e-01	1.48e-01	2.55e-01	4.18e-01
RHOJ GTPase cycle	50	7.35e-03	2.60e-02	0.25500	-4.23e-02	2.52e-01	6.04e-01	2.08e-03
Hyaluronan uptake and degradation	12	3.79e-01	5.22e-01	0.25500	-2.30e-01	1.11e-01	1.68e-01	5.06e-01
CHL1 interactions	8	4.79e-01	6.11e-01	0.25500	-6.52e-02	2.47e-01	7.49e-01	2.27e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	7.30e-02	1.60e-01	0.25500	2.41e-01	-8.18e-02	2.22e-02	4.38e-01
Thyroxine biosynthesis	5	6.53e-01	7.60e-01	0.25500	2.38e-01	-8.98e-02	3.56e-01	7.28e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	1.99e-01	3.29e-01	0.25500	-2.19e-01	1.30e-01	8.23e-02	3.03e-01
Synthesis of PIPs at the early endosome membrane	16	2.84e-01	4.26e-01	0.25400	2.25e-01	-1.18e-01	1.19e-01	4.12e-01
PI-3K cascade:FGFR2	13	1.75e-01	3.00e-01	0.25400	2.40e-01	8.35e-02	1.34e-01	6.02e-01
Class B/2 (Secretin family receptors)	55	9.26e-03	3.17e-02	0.25400	2.38e-01	-8.79e-02	2.22e-03	2.60e-01
Formation of axial mesoderm	6	4.87e-01	6.18e-01	0.25300	2.51e-01	3.56e-02	2.87e-01	8.80e-01
Negative regulation of FGFR2 signaling	24	1.80e-01	3.05e-01	0.25300	-1.78e-01	1.80e-01	1.31e-01	1.27e-01
Golgi-to-ER retrograde transport	123	1.54e-04	8.67e-04	0.25300	-1.91e-01	1.67e-01	2.59e-04	1.42e-03
Intrinsic Pathway for Apoptosis	54	1.27e-02	4.12e-02	0.25300	-2.31e-01	1.03e-01	3.31e-03	1.88e-01
Unwinding of DNA	12	2.04e-01	3.35e-01	0.25200	-2.37e-01	-8.55e-02	1.55e-01	6.08e-01
Vpr-mediated nuclear import of PICs	34	1.39e-02	4.43e-02	0.25200	-6.05e-02	-2.45e-01	5.42e-01	1.35e-02
Downstream signaling of activated FGFR3	17	9.20e-02	1.91e-01	0.25100	2.16e-01	1.28e-01	1.23e-01	3.59e-01
RHOBTB3 ATPase cycle	10	4.65e-01	6.00e-01	0.25100	-2.22e-01	1.16e-01	2.24e-01	5.24e-01
Mitotic G2-G2/M phases	179	4.61e-08	4.80e-07	0.25000	-2.47e-01	4.04e-02	1.17e-08	3.51e-01
GABA receptor activation	38	5.40e-03	2.03e-02	0.25000	2.21e-01	1.17e-01	1.83e-02	2.11e-01
PI Metabolism	79	1.51e-03	6.75e-03	0.25000	2.34e-01	-8.78e-02	3.14e-04	1.77e-01
NCAM1 interactions	27	8.78e-02	1.85e-01	0.25000	2.44e-01	-5.75e-02	2.85e-02	6.05e-01
TNFR2 non-canonical NF-kB pathway	84	7.96e-05	4.82e-04	0.25000	-2.49e-01	-2.04e-02	7.79e-05	7.46e-01
Activation of ATR in response to replication stress	37	1.40e-02	4.44e-02	0.25000	-2.48e-01	-3.10e-02	9.07e-03	7.44e-01
PLC beta mediated events	40	6.09e-02	1.41e-01	0.25000	1.93e-01	-1.59e-01	3.49e-02	8.24e-02
Nucleotide salvage	21	9.11e-02	1.90e-01	0.25000	-2.48e-01	-2.74e-02	4.91e-02	8.28e-01
RMTs methylate histone arginines	35	2.47e-02	7.05e-02	0.24900	-2.49e-01	9.98e-04	1.06e-02	9.92e-01
DNA Repair	289	3.80e-16	1.20e-14	0.24900	-2.41e-01	-6.39e-02	1.72e-12	6.17e-02
G1/S-Specific Transcription	29	6.11e-02	1.41e-01	0.24900	-2.47e-01	3.26e-02	2.12e-02	7.61e-01
Nephrin family interactions	20	7.62e-02	1.67e-01	0.24900	2.36e-01	8.18e-02	6.82e-02	5.27e-01
Cardiogenesis	16	3.05e-01	4.46e-01	0.24800	1.18e-01	-2.18e-01	4.13e-01	1.31e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	5.65e-02	1.32e-01	0.24700	-2.02e-01	1.43e-01	2.53e-02	1.13e-01
Signaling by RAS mutants	41	5.65e-02	1.32e-01	0.24700	-2.02e-01	1.43e-01	2.53e-02	1.13e-01
Signaling by moderate kinase activity BRAF mutants	41	5.65e-02	1.32e-01	0.24700	-2.02e-01	1.43e-01	2.53e-02	1.13e-01
Signaling downstream of RAS mutants	41	5.65e-02	1.32e-01	0.24700	-2.02e-01	1.43e-01	2.53e-02	1.13e-01
Infectious disease	959	1.94e-35	1.01e-33	0.24700	-2.39e-01	5.98e-02	2.86e-36	1.71e-03
TLR3-mediated TICAM1-dependent programmed cell death	6	6.67e-01	7.72e-01	0.24600	1.63e-01	-1.84e-01	4.89e-01	4.35e-01
Defensins	8	5.82e-01	6.95e-01	0.24600	-1.60e-01	1.87e-01	4.35e-01	3.59e-01
Plasma lipoprotein remodeling	18	2.87e-01	4.31e-01	0.24600	-1.42e-01	2.01e-01	2.98e-01	1.40e-01
Amino acid transport across the plasma membrane	26	1.50e-01	2.70e-01	0.24600	-1.16e-01	2.17e-01	3.07e-01	5.60e-02
Meiosis	67	5.02e-03	1.91e-02	0.24600	-2.30e-01	8.66e-02	1.14e-03	2.20e-01
G2/M Transition	177	7.33e-08	7.28e-07	0.24500	-2.43e-01	3.16e-02	2.35e-08	4.69e-01
Endosomal/Vacuolar pathway	12	3.24e-01	4.66e-01	0.24500	-2.43e-01	2.95e-02	1.44e-01	8.60e-01
Meiotic synapsis	43	4.77e-02	1.16e-01	0.24500	-2.10e-01	1.26e-01	1.73e-02	1.52e-01
Transcriptional Regulation by MECP2	49	2.12e-02	6.19e-02	0.24500	2.29e-01	-8.62e-02	5.52e-03	2.96e-01
Interactions of Vpr with host cellular proteins	37	8.37e-03	2.92e-02	0.24400	-1.05e-01	-2.21e-01	2.67e-01	2.02e-02
Apoptosis	158	8.96e-06	6.43e-05	0.24400	-2.20e-01	1.07e-01	1.85e-06	2.03e-02
Signaling by KIT in disease	20	2.27e-01	3.63e-01	0.24400	2.20e-01	-1.06e-01	8.84e-02	4.11e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	2.27e-01	3.63e-01	0.24400	2.20e-01	-1.06e-01	8.84e-02	4.11e-01
Norepinephrine Neurotransmitter Release Cycle	14	3.46e-01	4.89e-01	0.24300	9.41e-02	-2.24e-01	5.42e-01	1.46e-01
RNA Polymerase II Pre-transcription Events	77	2.83e-04	1.50e-03	0.24300	-2.42e-01	-2.03e-02	2.39e-04	7.58e-01
Cellular response to chemical stress	179	3.58e-06	2.72e-05	0.24300	-2.11e-01	1.20e-01	1.10e-06	5.53e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	1.74e-02	5.27e-02	0.24300	-1.71e-01	1.72e-01	1.97e-02	1.92e-02
Glutamate Neurotransmitter Release Cycle	20	2.64e-01	4.07e-01	0.24200	1.47e-01	-1.93e-01	2.56e-01	1.36e-01
CTNNB1 S33 mutants aren’t phosphorylated	15	1.34e-01	2.50e-01	0.24200	1.88e-01	1.53e-01	2.07e-01	3.06e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	1.34e-01	2.50e-01	0.24200	1.88e-01	1.53e-01	2.07e-01	3.06e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	1.34e-01	2.50e-01	0.24200	1.88e-01	1.53e-01	2.07e-01	3.06e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	1.34e-01	2.50e-01	0.24200	1.88e-01	1.53e-01	2.07e-01	3.06e-01
Signaling by CTNNB1 phospho-site mutants	15	1.34e-01	2.50e-01	0.24200	1.88e-01	1.53e-01	2.07e-01	3.06e-01
Signaling by GSK3beta mutants	15	1.34e-01	2.50e-01	0.24200	1.88e-01	1.53e-01	2.07e-01	3.06e-01
Glutamate and glutamine metabolism	12	4.17e-01	5.59e-01	0.24200	-2.19e-01	1.04e-01	1.90e-01	5.33e-01
Pyruvate metabolism	44	2.40e-02	6.85e-02	0.24200	-2.36e-01	5.32e-02	6.74e-03	5.42e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	6.31e-01	7.41e-01	0.24200	1.87e-01	-1.53e-01	3.91e-01	4.83e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	39	1.61e-02	4.95e-02	0.24100	2.40e-01	2.36e-02	9.43e-03	7.98e-01
Thrombin signalling through proteinase activated receptors (PARs)	27	1.47e-01	2.67e-01	0.24100	-1.11e-01	2.14e-01	3.17e-01	5.42e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	26	1.39e-01	2.56e-01	0.24100	2.25e-01	-8.69e-02	4.72e-02	4.43e-01
Viral Messenger RNA Synthesis	44	3.00e-03	1.24e-02	0.24100	-1.90e-01	-1.48e-01	2.94e-02	8.87e-02
ALK mutants bind TKIs	11	4.81e-01	6.13e-01	0.24100	1.97e-01	-1.39e-01	2.58e-01	4.25e-01
G-protein mediated events	44	5.54e-02	1.31e-01	0.24100	1.92e-01	-1.45e-01	2.72e-02	9.68e-02
M Phase	346	2.19e-12	4.56e-11	0.24100	-2.29e-01	7.36e-02	2.39e-13	1.86e-02
SUMO is proteolytically processed	6	4.61e-01	5.96e-01	0.24000	-2.05e-01	-1.26e-01	3.84e-01	5.94e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	5.45e-01	6.68e-01	0.24000	2.24e-01	8.70e-02	3.86e-01	7.36e-01
Depolymerization of the Nuclear Lamina	15	3.74e-01	5.16e-01	0.24000	-1.43e-01	1.93e-01	3.37e-01	1.96e-01
Downstream signaling of activated FGFR4	18	1.22e-01	2.35e-01	0.24000	2.30e-01	6.91e-02	9.12e-02	6.12e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	5.40e-01	6.66e-01	0.24000	-9.59e-02	-2.20e-01	7.10e-01	3.94e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	5.40e-01	6.66e-01	0.24000	-9.59e-02	-2.20e-01	7.10e-01	3.94e-01
Neddylation	215	1.28e-08	1.42e-07	0.24000	-2.35e-01	4.61e-02	2.66e-09	2.44e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	1.48e-01	2.68e-01	0.24000	-1.20e-01	-2.08e-01	4.22e-01	1.64e-01
Deadenylation-dependent mRNA decay	50	5.73e-03	2.14e-02	0.24000	-2.39e-01	-1.98e-02	3.49e-03	8.09e-01
Peroxisomal lipid metabolism	27	4.10e-02	1.03e-01	0.23900	-2.25e-01	-8.01e-02	4.31e-02	4.72e-01
Platelet sensitization by LDL	16	1.35e-01	2.50e-01	0.23900	2.10e-01	1.13e-01	1.46e-01	4.32e-01
Insulin processing	19	2.29e-01	3.64e-01	0.23900	2.28e-01	-7.19e-02	8.59e-02	5.87e-01
Signaling by FGFR3 in disease	14	1.80e-01	3.05e-01	0.23800	2.17e-01	9.96e-02	1.60e-01	5.19e-01
Detoxification of Reactive Oxygen Species	30	5.65e-02	1.32e-01	0.23800	-2.38e-01	3.31e-03	2.39e-02	9.75e-01
Trafficking of GluR2-containing AMPA receptors	11	4.79e-01	6.11e-01	0.23800	-2.03e-01	1.24e-01	2.43e-01	4.77e-01
HCMV Early Events	84	1.34e-03	6.10e-03	0.23800	-2.29e-01	6.54e-02	2.83e-04	3.00e-01
WNT5A-dependent internalization of FZD4	13	3.29e-01	4.71e-01	0.23800	-2.35e-01	4.01e-02	1.43e-01	8.02e-01
P2Y receptors	10	5.32e-01	6.60e-01	0.23800	1.67e-01	-1.70e-01	3.61e-01	3.53e-01
Signaling by RAF1 mutants	37	9.47e-02	1.94e-01	0.23800	-1.86e-01	1.48e-01	5.00e-02	1.20e-01
NPAS4 regulates expression of target genes	16	1.77e-01	3.02e-01	0.23800	4.24e-02	2.34e-01	7.69e-01	1.05e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	3.41e-02	9.14e-02	0.23700	-2.07e-01	1.15e-01	1.11e-02	1.60e-01
Termination of O-glycan biosynthesis	16	2.96e-01	4.39e-01	0.23700	2.25e-01	-7.41e-02	1.19e-01	6.08e-01
Signaling by LTK in cancer	7	4.44e-01	5.82e-01	0.23700	2.24e-01	7.64e-02	3.04e-01	7.26e-01
COPI-mediated anterograde transport	92	3.23e-03	1.32e-02	0.23700	-1.72e-01	1.63e-01	4.33e-03	6.90e-03
Transport of Mature Transcript to Cytoplasm	81	1.93e-04	1.07e-03	0.23700	-2.34e-01	-3.69e-02	2.71e-04	5.66e-01
Chemokine receptors bind chemokines	39	1.60e-02	4.93e-02	0.23700	3.89e-02	2.33e-01	6.74e-01	1.16e-02
Hemostasis	562	1.33e-15	3.92e-14	0.23600	-1.54e-01	1.79e-01	4.49e-10	3.71e-13
Formation of RNA Pol II elongation complex	56	3.99e-03	1.58e-02	0.23600	-2.36e-01	-1.39e-02	2.28e-03	8.58e-01
RNA Polymerase II Transcription Elongation	56	3.99e-03	1.58e-02	0.23600	-2.36e-01	-1.39e-02	2.28e-03	8.58e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	3.05e-01	4.46e-01	0.23600	1.21e-01	-2.03e-01	3.75e-01	1.36e-01
Phase 0 - rapid depolarisation	24	1.19e-01	2.32e-01	0.23600	2.35e-01	-2.08e-02	4.66e-02	8.60e-01
Neurofascin interactions	5	5.65e-01	6.82e-01	0.23600	7.47e-02	2.23e-01	7.72e-01	3.87e-01
APC truncation mutants have impaired AXIN binding	14	1.76e-01	3.00e-01	0.23500	1.98e-01	1.27e-01	2.00e-01	4.09e-01
AXIN missense mutants destabilize the destruction complex	14	1.76e-01	3.00e-01	0.23500	1.98e-01	1.27e-01	2.00e-01	4.09e-01
Signaling by AMER1 mutants	14	1.76e-01	3.00e-01	0.23500	1.98e-01	1.27e-01	2.00e-01	4.09e-01
Signaling by APC mutants	14	1.76e-01	3.00e-01	0.23500	1.98e-01	1.27e-01	2.00e-01	4.09e-01
Signaling by AXIN mutants	14	1.76e-01	3.00e-01	0.23500	1.98e-01	1.27e-01	2.00e-01	4.09e-01
Truncations of AMER1 destabilize the destruction complex	14	1.76e-01	3.00e-01	0.23500	1.98e-01	1.27e-01	2.00e-01	4.09e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	2.56e-01	3.98e-01	0.23500	-1.81e-01	1.49e-01	1.41e-01	2.26e-01
Apoptotic execution phase	46	5.16e-02	1.24e-01	0.23400	-1.24e-01	1.99e-01	1.46e-01	1.95e-02
Acyl chain remodelling of PI	10	3.36e-01	4.78e-01	0.23400	5.78e-02	2.27e-01	7.51e-01	2.14e-01
Uptake and function of diphtheria toxin	6	4.71e-01	6.05e-01	0.23400	-1.71e-01	-1.60e-01	4.69e-01	4.98e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	2.26e-03	9.65e-03	0.23400	-2.09e-01	1.05e-01	5.76e-04	8.26e-02
Amplification of signal from the kinetochores	91	2.26e-03	9.65e-03	0.23400	-2.09e-01	1.05e-01	5.76e-04	8.26e-02
DNA Double-Strand Break Repair	137	5.55e-07	4.77e-06	0.23400	-2.29e-01	-4.61e-02	3.60e-06	3.51e-01
NGF-stimulated transcription	32	1.44e-01	2.62e-01	0.23300	1.67e-01	-1.63e-01	1.02e-01	1.10e-01
SARS-CoV-2-host interactions	183	2.61e-09	3.21e-08	0.23300	-2.26e-01	-5.96e-02	1.39e-07	1.64e-01
CD28 dependent Vav1 pathway	12	4.70e-01	6.05e-01	0.23300	1.30e-01	-1.94e-01	4.37e-01	2.45e-01
Regulation of IFNG signaling	14	1.85e-01	3.12e-01	0.23300	1.21e-01	1.99e-01	4.34e-01	1.98e-01
Sphingolipid metabolism	91	4.14e-03	1.63e-02	0.23300	-1.53e-01	1.75e-01	1.17e-02	3.86e-03
Apoptotic cleavage of cell adhesion proteins	8	5.85e-01	6.98e-01	0.23200	-1.00e-01	2.10e-01	6.23e-01	3.05e-01
Asparagine N-linked glycosylation	286	1.65e-08	1.79e-07	0.23200	-1.98e-01	1.22e-01	8.54e-09	4.06e-04
Axon guidance	459	3.14e-13	8.08e-12	0.23100	-2.02e-01	1.12e-01	1.28e-13	3.94e-05
Dissolution of Fibrin Clot	12	2.94e-01	4.38e-01	0.23000	-2.26e-01	-4.30e-02	1.75e-01	7.97e-01
Dectin-2 family	19	1.34e-01	2.50e-01	0.23000	2.23e-01	5.85e-02	9.28e-02	6.59e-01
Activated NTRK3 signals through RAS	7	4.39e-01	5.79e-01	0.23000	1.99e-01	1.15e-01	3.61e-01	5.97e-01
Trafficking and processing of endosomal TLR	13	3.02e-01	4.45e-01	0.23000	-6.64e-03	-2.30e-01	9.67e-01	1.51e-01
Resolution of Sister Chromatid Cohesion	116	8.57e-04	4.08e-03	0.23000	-1.90e-01	1.29e-01	3.96e-04	1.61e-02
Sensing of DNA Double Strand Breaks	6	6.59e-01	7.67e-01	0.23000	8.21e-02	-2.15e-01	7.27e-01	3.62e-01
Downstream signaling of activated FGFR2	20	1.36e-01	2.52e-01	0.23000	2.27e-01	3.53e-02	7.85e-02	7.84e-01
RHO GTPase Effectors	258	3.07e-07	2.74e-06	0.22900	-1.71e-01	1.53e-01	2.37e-06	2.20e-05
Pyroptosis	25	6.11e-02	1.41e-01	0.22900	-2.11e-01	-8.90e-02	6.74e-02	4.41e-01
Fanconi Anemia Pathway	36	1.57e-02	4.86e-02	0.22900	-2.01e-01	-1.10e-01	3.72e-02	2.52e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.76e-01	4.20e-01	0.22900	1.93e-01	1.23e-01	2.68e-01	4.81e-01
Signaling by FLT3 ITD and TKD mutants	15	1.76e-01	3.00e-01	0.22900	1.98e-01	1.14e-01	1.85e-01	4.43e-01
Bile acid and bile salt metabolism	31	7.68e-02	1.68e-01	0.22800	2.27e-01	-2.27e-02	2.85e-02	8.27e-01
DAG and IP3 signaling	34	1.28e-01	2.44e-01	0.22800	1.90e-01	-1.26e-01	5.48e-02	2.02e-01
Thromboxane signalling through TP receptor	20	3.12e-01	4.53e-01	0.22800	-1.48e-01	1.74e-01	2.53e-01	1.78e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	4.85e-04	2.44e-03	0.22800	-2.17e-01	-6.87e-02	1.43e-03	3.13e-01
Synthesis of bile acids and bile salts	27	9.84e-02	2.01e-01	0.22800	2.28e-01	-9.64e-03	4.05e-02	9.31e-01
Miscellaneous transport and binding events	20	2.79e-01	4.23e-01	0.22800	-1.02e-01	2.04e-01	4.28e-01	1.15e-01
Negative regulation of MET activity	18	1.38e-01	2.55e-01	0.22700	8.85e-02	2.10e-01	5.16e-01	1.24e-01
MHC class II antigen presentation	113	1.58e-04	8.85e-04	0.22700	-2.24e-01	3.88e-02	3.89e-05	4.76e-01
Downstream TCR signaling	89	2.77e-04	1.47e-03	0.22700	-2.27e-01	-1.59e-02	2.17e-04	7.95e-01
DNA Double Strand Break Response	47	2.62e-02	7.40e-02	0.22600	-2.23e-01	3.69e-02	8.06e-03	6.62e-01
Translation of Structural Proteins 9683701	29	1.60e-01	2.82e-01	0.22600	-2.03e-01	9.96e-02	5.83e-02	3.53e-01
IGF1R signaling cascade	38	2.32e-02	6.66e-02	0.22500	2.20e-01	4.78e-02	1.87e-02	6.10e-01
PI3K/AKT activation	8	4.14e-01	5.58e-01	0.22500	9.91e-02	2.02e-01	6.27e-01	3.22e-01
COPI-dependent Golgi-to-ER retrograde traffic	90	5.86e-03	2.18e-02	0.22500	-1.78e-01	1.38e-01	3.58e-03	2.33e-02
IRS-related events triggered by IGF1R	37	2.62e-02	7.40e-02	0.22500	2.20e-01	4.67e-02	2.05e-02	6.23e-01
ChREBP activates metabolic gene expression	7	5.41e-01	6.66e-01	0.22500	5.56e-03	2.25e-01	9.80e-01	3.03e-01
RAS signaling downstream of NF1 loss-of-function variants	7	5.01e-01	6.28e-01	0.22500	2.19e-01	4.86e-02	3.15e-01	8.24e-01
Diseases associated with glycosaminoglycan metabolism	25	2.27e-01	3.63e-01	0.22400	-1.93e-01	1.13e-01	9.50e-02	3.27e-01
Gap junction assembly	17	3.43e-01	4.86e-01	0.22300	-9.01e-02	2.04e-01	5.20e-01	1.45e-01
Signaling by TGFBR3	39	1.06e-01	2.13e-01	0.22300	1.86e-01	-1.23e-01	4.44e-02	1.85e-01
Activation of GABAB receptors	31	3.93e-02	1.01e-01	0.22300	2.07e-01	8.17e-02	4.60e-02	4.31e-01
GABA B receptor activation	31	3.93e-02	1.01e-01	0.22300	2.07e-01	8.17e-02	4.60e-02	4.31e-01
Metabolism of steroid hormones	22	2.19e-01	3.53e-01	0.22200	-2.14e-01	6.03e-02	8.22e-02	6.25e-01
Iron uptake and transport	52	3.86e-02	9.95e-02	0.22100	-2.04e-01	8.58e-02	1.10e-02	2.84e-01
Fertilization	12	3.02e-01	4.45e-01	0.22100	-6.65e-02	-2.11e-01	6.90e-01	2.07e-01
Sphingolipid catabolism	11	5.40e-01	6.66e-01	0.22100	-1.27e-01	1.81e-01	4.67e-01	2.99e-01
Metabolism	1835	9.92e-62	3.83e-59	0.22100	-2.21e-01	2.74e-04	1.10e-55	9.84e-01
Vitamin D (calciferol) metabolism	11	2.92e-01	4.37e-01	0.22100	-1.59e-01	-1.53e-01	3.63e-01	3.78e-01
Laminin interactions	26	5.70e-02	1.33e-01	0.22000	1.30e-01	1.78e-01	2.52e-01	1.16e-01
Biosynthesis of EPA-derived SPMs	6	6.36e-01	7.45e-01	0.22000	2.19e-01	-2.82e-02	3.54e-01	9.05e-01
Phospholipase C-mediated cascade; FGFR2	8	6.42e-01	7.49e-01	0.22000	1.28e-01	-1.79e-01	5.31e-01	3.81e-01
RHOU GTPase cycle	40	5.41e-02	1.29e-01	0.22000	2.17e-01	-3.74e-02	1.76e-02	6.83e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	3.60e-01	5.02e-01	0.22000	-2.19e-01	1.43e-02	1.71e-01	9.29e-01
Regulation of TP53 Activity through Methylation	19	1.29e-01	2.45e-01	0.21900	-1.19e-01	-1.84e-01	3.69e-01	1.65e-01
EML4 and NUDC in mitotic spindle formation	107	2.77e-03	1.15e-02	0.21900	-1.81e-01	1.23e-01	1.23e-03	2.74e-02
Role of ABL in ROBO-SLIT signaling	6	5.35e-01	6.62e-01	0.21900	1.95e-01	9.84e-02	4.07e-01	6.76e-01
Killing mechanisms	9	3.97e-01	5.41e-01	0.21800	-9.18e-02	-1.98e-01	6.33e-01	3.04e-01
WNT5:FZD7-mediated leishmania damping	9	3.97e-01	5.41e-01	0.21800	-9.18e-02	-1.98e-01	6.33e-01	3.04e-01
Glycine degradation	7	6.68e-01	7.72e-01	0.21800	-1.93e-01	1.01e-01	3.77e-01	6.43e-01
CaM pathway	28	2.10e-01	3.42e-01	0.21800	1.85e-01	-1.14e-01	8.94e-02	2.97e-01
Calmodulin induced events	28	2.10e-01	3.42e-01	0.21800	1.85e-01	-1.14e-01	8.94e-02	2.97e-01
Hedgehog ‘on’ state	65	1.19e-02	3.90e-02	0.21800	-2.12e-01	4.93e-02	3.13e-03	4.92e-01
RUNX3 regulates WNT signaling	8	5.97e-01	7.10e-01	0.21700	2.07e-01	-6.60e-02	3.10e-01	7.47e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	6.39e-01	7.47e-01	0.21700	-3.49e-02	-2.15e-01	8.92e-01	4.06e-01
Regulation of pyruvate metabolism	32	1.72e-01	2.97e-01	0.21700	-1.83e-01	1.17e-01	7.32e-02	2.51e-01
Tryptophan catabolism	12	2.74e-01	4.18e-01	0.21700	-1.56e-01	-1.51e-01	3.50e-01	3.66e-01
Signaling by ERBB2 TMD/JMD mutants	17	4.09e-01	5.54e-01	0.21700	1.65e-01	-1.41e-01	2.39e-01	3.15e-01
Nonhomologous End-Joining (NHEJ)	40	8.24e-02	1.77e-01	0.21700	-2.04e-01	7.21e-02	2.55e-02	4.30e-01
Constitutive Signaling by EGFRvIII	14	3.20e-01	4.62e-01	0.21600	2.16e-01	6.43e-03	1.61e-01	9.67e-01
Signaling by EGFRvIII in Cancer	14	3.20e-01	4.62e-01	0.21600	2.16e-01	6.43e-03	1.61e-01	9.67e-01
Activation of PUMA and translocation to mitochondria	9	5.22e-01	6.48e-01	0.21600	2.14e-01	-2.90e-02	2.66e-01	8.80e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	3.81e-02	9.89e-02	0.21600	-2.13e-01	3.25e-02	1.23e-02	7.03e-01
ER Quality Control Compartment (ERQC)	21	3.33e-01	4.74e-01	0.21600	-1.69e-01	1.35e-01	1.81e-01	2.86e-01
Disorders of transmembrane transporters	137	1.10e-04	6.46e-04	0.21600	-2.10e-01	4.98e-02	2.24e-05	3.15e-01
Signaling by FGFR2	61	4.17e-02	1.04e-01	0.21500	-1.67e-01	1.37e-01	2.44e-02	6.49e-02
Interferon alpha/beta signaling	64	1.16e-03	5.35e-03	0.21500	-1.48e-01	-1.56e-01	4.07e-02	3.11e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	3.96e-01	5.40e-01	0.21500	1.10e-01	-1.84e-01	4.32e-01	1.88e-01
Activation of HOX genes during differentiation	70	1.78e-02	5.38e-02	0.21400	-1.95e-01	9.00e-02	4.86e-03	1.93e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	70	1.78e-02	5.38e-02	0.21400	-1.95e-01	9.00e-02	4.86e-03	1.93e-01
TP53 Regulates Transcription of DNA Repair Genes	61	4.56e-03	1.76e-02	0.21400	-2.10e-01	-4.16e-02	4.53e-03	5.74e-01
FLT3 signaling through SRC family kinases	6	6.35e-01	7.44e-01	0.21400	2.14e-01	-9.00e-03	3.65e-01	9.70e-01
SARS-CoV-2 Infection	267	1.24e-09	1.63e-08	0.21400	-2.14e-01	2.74e-04	1.87e-09	9.94e-01
HATs acetylate histones	92	9.11e-03	3.14e-02	0.21300	-1.66e-01	1.34e-01	5.84e-03	2.68e-02
Synthesis, secretion, and deacylation of Ghrelin	11	3.18e-01	4.61e-01	0.21300	-1.62e-01	-1.39e-01	3.52e-01	4.26e-01
RHO GTPases Activate Formins	128	6.71e-04	3.26e-03	0.21300	-1.95e-01	8.66e-02	1.43e-04	9.08e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	1.65e-01	2.89e-01	0.21300	2.03e-01	-6.28e-02	5.79e-02	5.59e-01
STAT5 activation downstream of FLT3 ITD mutants	9	4.07e-01	5.52e-01	0.21300	1.03e-01	1.86e-01	5.92e-01	3.33e-01
RHO GTPases activate PAKs	20	2.08e-01	3.40e-01	0.21300	5.71e-03	2.13e-01	9.65e-01	9.96e-02
Uptake and function of anthrax toxins	11	3.55e-01	4.98e-01	0.21300	7.16e-02	2.00e-01	6.81e-01	2.50e-01
Nervous system development	478	5.49e-12	1.06e-10	0.21200	-1.89e-01	9.61e-02	1.27e-12	3.17e-04
Transport of Ribonucleoproteins into the Host Nucleus	32	7.73e-02	1.68e-01	0.21200	-1.30e-02	-2.12e-01	8.99e-01	3.80e-02
Signaling by Retinoic Acid	29	9.03e-02	1.89e-01	0.21200	-2.52e-02	-2.11e-01	8.15e-01	4.96e-02
Transcriptional regulation by RUNX3	81	1.22e-02	3.96e-02	0.21200	-1.87e-01	9.98e-02	3.60e-03	1.20e-01
FGFRL1 modulation of FGFR1 signaling	7	5.75e-01	6.90e-01	0.21200	2.12e-01	9.69e-03	3.32e-01	9.65e-01
Beta-catenin phosphorylation cascade	17	1.89e-01	3.17e-01	0.21200	9.71e-02	1.88e-01	4.88e-01	1.79e-01
Netrin-1 signaling	35	3.71e-02	9.74e-02	0.21100	7.74e-02	1.97e-01	4.28e-01	4.40e-02
SARS-CoV Infections	433	7.50e-13	1.71e-11	0.21100	-2.07e-01	4.29e-02	1.46e-13	1.26e-01
Formation of the Editosome	6	5.66e-01	6.83e-01	0.21100	8.11e-02	1.95e-01	7.31e-01	4.08e-01
mRNA Editing: C to U Conversion	6	5.66e-01	6.83e-01	0.21100	8.11e-02	1.95e-01	7.31e-01	4.08e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	5.59e-01	6.79e-01	0.21100	-1.97e-01	7.57e-02	2.81e-01	6.78e-01
Defective EXT2 causes exostoses 2	10	5.59e-01	6.79e-01	0.21100	-1.97e-01	7.57e-02	2.81e-01	6.78e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	2.57e-01	3.98e-01	0.21000	-2.00e-01	-6.41e-02	1.79e-01	6.68e-01
AMPK inhibits chREBP transcriptional activation activity	6	7.44e-01	8.30e-01	0.21000	-1.53e-01	1.45e-01	5.17e-01	5.40e-01
Activation of RAC1	11	4.94e-01	6.23e-01	0.21000	2.05e-01	-4.63e-02	2.39e-01	7.91e-01
Interleukin-1 signaling	99	4.44e-03	1.72e-02	0.21000	-1.90e-01	9.07e-02	1.11e-03	1.19e-01
Activation of the AP-1 family of transcription factors	10	4.38e-01	5.79e-01	0.21000	2.96e-02	2.08e-01	8.71e-01	2.55e-01
Inhibition of Signaling by Overexpressed EGFR	6	5.66e-01	6.83e-01	0.20900	1.89e-01	8.93e-02	4.22e-01	7.05e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	6	5.66e-01	6.83e-01	0.20900	1.89e-01	8.93e-02	4.22e-01	7.05e-01
FRS-mediated FGFR1 signaling	15	2.78e-01	4.23e-01	0.20900	4.46e-02	2.04e-01	7.65e-01	1.70e-01
Ca-dependent events	30	2.10e-01	3.42e-01	0.20900	1.81e-01	-1.04e-01	8.61e-02	3.25e-01
Signaling by Insulin receptor	63	1.85e-02	5.50e-02	0.20900	-4.47e-02	2.04e-01	5.39e-01	5.14e-03
M-decay: degradation of maternal mRNAs by maternally stored factors	41	9.74e-02	1.99e-01	0.20900	-7.54e-02	1.95e-01	4.04e-01	3.11e-02
RHOQ GTPase cycle	55	2.16e-02	6.29e-02	0.20800	-1.65e-02	2.08e-01	8.33e-01	7.73e-03
EPH-Ephrin signaling	81	1.46e-02	4.58e-02	0.20800	-9.99e-02	1.83e-01	1.20e-01	4.47e-03
TICAM1-dependent activation of IRF3/IRF7	13	4.26e-01	5.68e-01	0.20800	3.20e-02	-2.05e-01	8.41e-01	2.01e-01
SUMOylation of SUMOylation proteins	35	3.68e-02	9.68e-02	0.20800	-9.69e-02	-1.83e-01	3.21e-01	6.03e-02
NOTCH4 Intracellular Domain Regulates Transcription	19	3.08e-01	4.49e-01	0.20700	2.02e-01	-4.78e-02	1.28e-01	7.18e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	2.14e-01	3.46e-01	0.20700	-1.95e-01	7.02e-02	7.91e-02	5.28e-01
Sodium-coupled phosphate cotransporters	5	7.78e-01	8.52e-01	0.20700	1.75e-01	-1.11e-01	4.98e-01	6.67e-01
PKMTs methylate histone lysines	44	1.22e-01	2.36e-01	0.20700	1.52e-01	-1.41e-01	8.03e-02	1.07e-01
Metalloprotease DUBs	20	3.65e-01	5.06e-01	0.20700	-1.76e-01	1.09e-01	1.72e-01	3.99e-01
Cell Cycle	611	2.77e-18	9.74e-17	0.20700	-2.06e-01	2.16e-02	3.15e-18	3.62e-01
Diseases of DNA repair	51	1.17e-02	3.86e-02	0.20700	-1.98e-01	-6.10e-02	1.45e-02	4.51e-01
Transcriptional Regulation by VENTX	39	9.20e-02	1.91e-01	0.20700	4.92e-02	-2.01e-01	5.95e-01	2.99e-02
Signaling by ERBB2 ECD mutants	15	2.71e-01	4.15e-01	0.20700	1.97e-01	6.10e-02	1.86e-01	6.82e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	3.02e-01	4.45e-01	0.20600	1.60e-01	-1.31e-01	1.67e-01	2.57e-01
Interleukin-27 signaling	11	4.70e-01	6.05e-01	0.20600	-1.55e-02	2.05e-01	9.29e-01	2.38e-01
MAPK3 (ERK1) activation	10	4.44e-01	5.82e-01	0.20500	3.93e-02	2.01e-01	8.30e-01	2.70e-01
Biosynthesis of maresin-like SPMs	5	7.50e-01	8.32e-01	0.20500	1.96e-01	-5.97e-02	4.49e-01	8.17e-01
Ub-specific processing proteases	153	3.85e-04	1.97e-03	0.20400	-1.84e-01	8.94e-02	8.78e-05	5.63e-02
Cell Cycle, Mitotic	488	3.57e-14	9.58e-13	0.20400	-2.03e-01	2.63e-02	1.77e-14	3.19e-01
Signal amplification	28	2.64e-01	4.07e-01	0.20400	-1.18e-01	1.66e-01	2.79e-01	1.29e-01
Regulation of gene expression by Hypoxia-inducible Factor	8	5.41e-01	6.66e-01	0.20300	2.02e-01	2.67e-02	3.23e-01	8.96e-01
Vesicle-mediated transport	669	1.04e-13	2.70e-12	0.20300	-1.51e-01	1.36e-01	2.85e-11	1.96e-09
G-protein activation	19	4.12e-01	5.56e-01	0.20300	-1.22e-01	1.62e-01	3.56e-01	2.22e-01
Nuclear import of Rev protein	34	4.69e-02	1.15e-01	0.20300	-9.35e-02	-1.80e-01	3.45e-01	6.93e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	6.32e-01	7.42e-01	0.20300	2.02e-01	-1.93e-02	3.55e-01	9.29e-01
Potential therapeutics for SARS	149	9.16e-04	4.34e-03	0.20200	-1.67e-01	1.14e-01	4.30e-04	1.61e-02
Programmed Cell Death	187	8.35e-05	5.00e-04	0.20200	-1.82e-01	8.82e-02	1.81e-05	3.75e-02
RHO GTPases activate CIT	18	4.43e-01	5.82e-01	0.20100	-1.48e-01	1.37e-01	2.79e-01	3.14e-01
RHOV GTPase cycle	36	1.32e-01	2.48e-01	0.20100	1.93e-01	-5.50e-02	4.46e-02	5.68e-01
PI3K Cascade	31	6.99e-02	1.55e-01	0.20000	1.84e-01	8.01e-02	7.67e-02	4.40e-01
Eicosanoids	6	5.78e-01	6.92e-01	0.20000	1.25e-01	1.56e-01	5.97e-01	5.07e-01
Cell junction organization	82	2.30e-02	6.63e-02	0.20000	1.65e-01	-1.12e-01	9.63e-03	7.85e-02
CDC6 association with the ORC:origin complex	8	5.18e-01	6.46e-01	0.20000	-1.89e-01	-6.44e-02	3.55e-01	7.52e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	6.43e-01	7.50e-01	0.19900	-1.98e-01	2.02e-02	3.63e-01	9.26e-01
Defects in cobalamin (B12) metabolism	13	3.32e-01	4.74e-01	0.19900	-7.86e-02	-1.83e-01	6.24e-01	2.53e-01
CREB phosphorylation	7	6.02e-01	7.15e-01	0.19900	1.98e-01	2.14e-02	3.65e-01	9.22e-01
Dopamine Neurotransmitter Release Cycle	20	4.12e-01	5.56e-01	0.19900	1.54e-01	-1.26e-01	2.34e-01	3.31e-01
Mucopolysaccharidoses	11	6.16e-01	7.29e-01	0.19800	-1.32e-01	1.48e-01	4.48e-01	3.95e-01
Cargo recognition for clathrin-mediated endocytosis	89	1.96e-02	5.78e-02	0.19800	-1.55e-01	1.24e-01	1.17e-02	4.24e-02
NCAM signaling for neurite out-growth	48	6.32e-02	1.44e-01	0.19800	1.94e-01	-4.07e-02	2.01e-02	6.26e-01
Mitotic Prophase	96	6.95e-03	2.49e-02	0.19800	-1.86e-01	6.78e-02	1.62e-03	2.51e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.01e-02	3.41e-02	0.19800	-1.97e-01	1.99e-02	3.38e-03	7.68e-01
Signaling by ERBB2 in Cancer	21	2.74e-01	4.18e-01	0.19800	1.97e-01	-2.13e-02	1.19e-01	8.66e-01
Transferrin endocytosis and recycling	26	2.93e-01	4.38e-01	0.19700	-9.33e-02	1.74e-01	4.10e-01	1.25e-01
Regulation of localization of FOXO transcription factors	11	6.10e-01	7.24e-01	0.19700	-1.11e-01	1.63e-01	5.22e-01	3.50e-01
Signaling by cytosolic FGFR1 fusion mutants	18	3.46e-01	4.89e-01	0.19700	1.95e-01	-3.21e-02	1.53e-01	8.13e-01
Homologous DNA Pairing and Strand Exchange	43	3.24e-02	8.75e-02	0.19700	-1.87e-01	-6.21e-02	3.39e-02	4.81e-01
Metabolism of Angiotensinogen to Angiotensins	12	4.79e-01	6.11e-01	0.19700	1.96e-01	-2.03e-02	2.40e-01	9.03e-01
PKA activation	15	3.01e-01	4.44e-01	0.19700	1.86e-01	6.37e-02	2.12e-01	6.69e-01
SUMOylation of RNA binding proteins	47	1.65e-02	5.05e-02	0.19700	-1.61e-01	-1.13e-01	5.61e-02	1.81e-01
Activation of BH3-only proteins	30	2.58e-01	3.99e-01	0.19700	-1.66e-01	1.05e-01	1.15e-01	3.19e-01
Kidney development	17	4.32e-01	5.74e-01	0.19600	-7.63e-02	1.81e-01	5.86e-01	1.96e-01
Ethanol oxidation	8	5.72e-01	6.87e-01	0.19600	-1.96e-01	-1.77e-02	3.38e-01	9.31e-01
Deactivation of the beta-catenin transactivating complex	36	2.06e-01	3.37e-01	0.19500	1.11e-01	-1.61e-01	2.48e-01	9.52e-02
Activation of C3 and C5	7	6.62e-01	7.69e-01	0.19500	-1.94e-01	2.68e-02	3.75e-01	9.02e-01
EGFR Transactivation by Gastrin	7	7.43e-01	8.30e-01	0.19500	1.37e-01	-1.40e-01	5.31e-01	5.23e-01
Drug ADME	59	1.20e-02	3.93e-02	0.19500	-1.90e-01	-4.44e-02	1.15e-02	5.56e-01
mRNA Editing	8	5.92e-01	7.04e-01	0.19500	1.95e-01	2.49e-03	3.39e-01	9.90e-01
DARPP-32 events	22	3.55e-01	4.98e-01	0.19500	-8.64e-02	1.75e-01	4.83e-01	1.55e-01
Ion transport by P-type ATPases	43	1.40e-01	2.57e-01	0.19500	1.71e-01	-9.42e-02	5.26e-02	2.85e-01
Biosynthesis of maresins	7	7.00e-01	7.98e-01	0.19400	1.84e-01	-6.08e-02	3.99e-01	7.81e-01
Interleukin-35 Signalling	12	4.53e-01	5.89e-01	0.19400	8.16e-03	1.94e-01	9.61e-01	2.45e-01
E2F mediated regulation of DNA replication	22	2.94e-01	4.38e-01	0.19400	-1.90e-01	3.69e-02	1.23e-01	7.65e-01
Transcriptional regulation of brown and beige adipocyte differentiation	24	3.66e-01	5.07e-01	0.19300	1.49e-01	-1.23e-01	2.07e-01	2.95e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	24	3.66e-01	5.07e-01	0.19300	1.49e-01	-1.23e-01	2.07e-01	2.95e-01
FLT3 signaling in disease	27	2.81e-01	4.23e-01	0.19300	1.76e-01	-7.83e-02	1.13e-01	4.81e-01
ERKs are inactivated	13	5.60e-01	6.79e-01	0.19300	-1.68e-01	9.43e-02	2.94e-01	5.56e-01
Interactions of Rev with host cellular proteins	37	4.29e-02	1.07e-01	0.19300	-1.29e-01	-1.43e-01	1.74e-01	1.32e-01
SUMOylation of DNA replication proteins	46	1.99e-02	5.85e-02	0.19300	-1.33e-01	-1.40e-01	1.20e-01	1.00e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.01e-01	2.05e-01	0.19300	-3.73e-02	-1.89e-01	7.15e-01	6.43e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.01e-01	2.05e-01	0.19300	-3.73e-02	-1.89e-01	7.15e-01	6.43e-02
Interleukin-4 and Interleukin-13 signaling	93	1.46e-03	6.57e-03	0.19300	1.90e-01	3.24e-02	1.55e-03	5.90e-01
Downregulation of TGF-beta receptor signaling	26	3.31e-01	4.73e-01	0.19200	-1.58e-01	1.09e-01	1.62e-01	3.36e-01
Aspartate and asparagine metabolism	9	6.68e-01	7.72e-01	0.19200	8.77e-02	-1.70e-01	6.49e-01	3.76e-01
SUMOylation of chromatin organization proteins	57	9.10e-03	3.14e-02	0.19100	-1.10e-01	-1.56e-01	1.51e-01	4.11e-02
Mitochondrial biogenesis	91	5.11e-03	1.94e-02	0.19100	-1.90e-01	1.82e-02	1.70e-03	7.65e-01
Transport of fatty acids	5	7.43e-01	8.30e-01	0.19100	-1.27e-02	1.91e-01	9.61e-01	4.60e-01
Collagen chain trimerization	29	1.50e-01	2.70e-01	0.19100	1.90e-01	1.43e-02	7.58e-02	8.94e-01
Postmitotic nuclear pore complex (NPC) reformation	27	1.32e-01	2.48e-01	0.19000	-1.80e-01	-6.28e-02	1.06e-01	5.72e-01
Rev-mediated nuclear export of HIV RNA	35	5.52e-02	1.31e-01	0.19000	-1.26e-01	-1.43e-01	1.98e-01	1.44e-01
Triglyceride metabolism	26	1.21e-01	2.34e-01	0.19000	1.57e-01	1.07e-01	1.66e-01	3.44e-01
Intraflagellar transport	47	3.10e-02	8.41e-02	0.19000	-5.89e-02	-1.81e-01	4.85e-01	3.23e-02
IRS-mediated signalling	35	7.08e-02	1.57e-01	0.19000	1.77e-01	6.83e-02	6.98e-02	4.85e-01
WNT ligand biogenesis and trafficking	19	4.13e-01	5.57e-01	0.19000	1.76e-01	-7.05e-02	1.84e-01	5.95e-01
Clathrin-mediated endocytosis	128	5.92e-03	2.19e-02	0.19000	-1.22e-01	1.45e-01	1.72e-02	4.58e-03
Gastrulation	76	2.94e-02	8.08e-02	0.18900	-1.76e-01	7.01e-02	7.99e-03	2.91e-01
Collagen degradation	44	2.90e-02	7.99e-02	0.18900	1.58e-01	1.04e-01	7.00e-02	2.31e-01
PKA-mediated phosphorylation of CREB	17	3.91e-01	5.35e-01	0.18900	1.87e-01	-2.58e-02	1.81e-01	8.54e-01
Transport to the Golgi and subsequent modification	171	1.16e-03	5.36e-03	0.18800	-1.44e-01	1.21e-01	1.15e-03	6.18e-03
Inwardly rectifying K+ channels	24	1.50e-01	2.70e-01	0.18800	9.78e-02	1.61e-01	4.07e-01	1.73e-01
PECAM1 interactions	12	5.16e-01	6.44e-01	0.18800	1.86e-01	-2.22e-02	2.63e-01	8.94e-01
Constitutive Signaling by Aberrant PI3K in Cancer	59	2.20e-02	6.40e-02	0.18700	1.86e-01	2.24e-02	1.34e-02	7.66e-01
Cargo trafficking to the periciliary membrane	47	3.47e-02	9.22e-02	0.18700	-5.54e-02	-1.79e-01	5.11e-01	3.37e-02
Attenuation phase	23	1.99e-01	3.29e-01	0.18700	-4.92e-02	-1.80e-01	6.83e-01	1.34e-01
Mitochondrial unfolded protein response (UPRmt)	17	3.31e-01	4.73e-01	0.18700	-2.46e-02	-1.85e-01	8.60e-01	1.86e-01
ECM proteoglycans	48	5.44e-02	1.30e-01	0.18700	6.24e-03	1.87e-01	9.40e-01	2.53e-02
Activated NTRK2 signals through FRS2 and FRS3	8	5.29e-01	6.56e-01	0.18600	1.33e-01	1.30e-01	5.14e-01	5.23e-01
MAPK1 (ERK2) activation	9	5.00e-01	6.28e-01	0.18600	9.71e-02	1.58e-01	6.14e-01	4.11e-01
Hyaluronan metabolism	16	4.48e-01	5.86e-01	0.18600	-1.81e-01	3.94e-02	2.09e-01	7.85e-01
Signaling by MET	68	1.84e-02	5.46e-02	0.18500	2.96e-03	1.85e-01	9.66e-01	8.37e-03
PKA activation in glucagon signalling	14	3.91e-01	5.35e-01	0.18500	1.80e-01	4.19e-02	2.44e-01	7.86e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	187	7.44e-04	3.61e-03	0.18500	-1.09e-01	1.49e-01	9.99e-03	4.51e-04
EPHA-mediated growth cone collapse	21	2.68e-01	4.11e-01	0.18400	2.23e-02	1.83e-01	8.59e-01	1.47e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	5.52e-02	1.31e-01	0.18400	-1.73e-01	-6.34e-02	5.54e-02	4.83e-01
Diseases of DNA Double-Strand Break Repair	41	5.52e-02	1.31e-01	0.18400	-1.73e-01	-6.34e-02	5.54e-02	4.83e-01
Export of Viral Ribonucleoproteins from Nucleus	33	1.08e-01	2.16e-01	0.18400	-4.64e-02	-1.78e-01	6.45e-01	7.65e-02
Costimulation by the CD28 family	74	3.97e-02	1.02e-01	0.18400	6.90e-02	-1.70e-01	3.05e-01	1.12e-02
Receptor-type tyrosine-protein phosphatases	12	4.85e-01	6.17e-01	0.18400	1.83e-01	1.30e-02	2.72e-01	9.38e-01
Signaling by EGFR	48	4.76e-02	1.16e-01	0.18300	2.91e-02	1.81e-01	7.27e-01	3.00e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	191	7.79e-04	3.74e-03	0.18300	-1.42e-01	1.16e-01	7.37e-04	5.54e-03
VxPx cargo-targeting to cilium	19	2.51e-01	3.90e-01	0.18300	1.65e-01	8.00e-02	2.13e-01	5.46e-01
Early SARS-CoV-2 Infection Events	31	1.97e-01	3.27e-01	0.18300	-1.82e-01	2.16e-02	8.00e-02	8.35e-01
Regulation of TP53 Activity through Phosphorylation	88	9.56e-03	3.25e-02	0.18300	-1.82e-01	1.87e-02	3.17e-03	7.62e-01
Signaling by Leptin	10	4.91e-01	6.21e-01	0.18300	1.69e-01	7.10e-02	3.56e-01	6.97e-01
Synthesis of very long-chain fatty acyl-CoAs	22	4.18e-01	5.60e-01	0.18300	-9.25e-02	1.58e-01	4.52e-01	2.01e-01
Regulation of TP53 Expression and Degradation	36	2.57e-01	3.98e-01	0.18200	-1.46e-01	1.10e-01	1.31e-01	2.55e-01
Activation of G protein gated Potassium channels	20	2.22e-01	3.57e-01	0.18200	1.09e-01	1.45e-01	3.98e-01	2.60e-01
G protein gated Potassium channels	20	2.22e-01	3.57e-01	0.18200	1.09e-01	1.45e-01	3.98e-01	2.60e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	2.22e-01	3.57e-01	0.18200	1.09e-01	1.45e-01	3.98e-01	2.60e-01
Gap junction trafficking	28	3.07e-01	4.49e-01	0.18200	-7.13e-02	1.67e-01	5.14e-01	1.26e-01
CLEC7A (Dectin-1) signaling	86	1.40e-02	4.44e-02	0.18200	-1.79e-01	3.04e-02	4.09e-03	6.26e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	4.74e-01	6.08e-01	0.18200	1.11e-01	-1.44e-01	3.90e-01	2.66e-01
Phospholipase C-mediated cascade; FGFR4	6	7.97e-01	8.69e-01	0.18100	1.03e-01	-1.49e-01	6.62e-01	5.27e-01
SARS-CoV-1 activates/modulates innate immune responses	40	6.24e-02	1.43e-01	0.18100	-6.79e-02	-1.68e-01	4.58e-01	6.60e-02
Maturation of nucleoprotein 9694631	15	4.53e-01	5.89e-01	0.18100	-1.42e-02	1.80e-01	9.24e-01	2.26e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	6.26e-02	1.43e-01	0.18000	-1.66e-01	-7.10e-02	6.96e-02	4.37e-01
DAP12 interactions	39	5.67e-02	1.33e-01	0.18000	1.45e-01	1.07e-01	1.18e-01	2.46e-01
Formation of the cornified envelope	36	1.67e-01	2.91e-01	0.18000	-2.65e-02	1.78e-01	7.83e-01	6.43e-02
The NLRP3 inflammasome	16	3.92e-01	5.36e-01	0.18000	-1.58e-02	-1.79e-01	9.13e-01	2.15e-01
Regulation of KIT signaling	15	5.54e-01	6.75e-01	0.18000	1.59e-01	-8.37e-02	2.86e-01	5.75e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	19	4.51e-01	5.89e-01	0.17900	1.67e-01	-6.59e-02	2.08e-01	6.19e-01
Processing of Intronless Pre-mRNAs	20	4.33e-01	5.74e-01	0.17900	-1.67e-01	6.46e-02	1.96e-01	6.17e-01
ERBB2 Activates PTK6 Signaling	8	6.80e-01	7.83e-01	0.17900	1.76e-01	-3.06e-02	3.88e-01	8.81e-01
Erythropoietin activates Phospholipase C gamma (PLCG)	6	6.96e-01	7.94e-01	0.17900	1.77e-01	2.83e-02	4.54e-01	9.04e-01
Transport of bile salts and organic acids, metal ions and amine compounds	52	4.43e-02	1.09e-01	0.17900	2.73e-02	1.76e-01	7.33e-01	2.77e-02
NEP/NS2 Interacts with the Cellular Export Machinery	32	1.11e-01	2.21e-01	0.17800	-7.68e-02	-1.61e-01	4.52e-01	1.15e-01
HS-GAG biosynthesis	20	4.93e-01	6.22e-01	0.17800	-1.20e-01	1.31e-01	3.52e-01	3.09e-01
Transcriptional Regulation by E2F6	34	1.12e-01	2.22e-01	0.17800	-1.70e-01	-5.22e-02	8.61e-02	5.98e-01
Maturation of nucleoprotein 9683610	11	6.25e-01	7.39e-01	0.17800	-5.63e-02	1.69e-01	7.47e-01	3.33e-01
HSF1-dependent transactivation	30	1.66e-01	2.89e-01	0.17800	-2.93e-02	-1.75e-01	7.81e-01	9.66e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	2.80e-01	4.23e-01	0.17700	-1.77e-01	1.22e-02	1.26e-01	9.16e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	2.80e-01	4.23e-01	0.17700	-1.77e-01	1.22e-02	1.26e-01	9.16e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	2.80e-01	4.23e-01	0.17700	-1.77e-01	1.22e-02	1.26e-01	9.16e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	2.80e-01	4.23e-01	0.17700	-1.77e-01	1.22e-02	1.26e-01	9.16e-01
Plasma lipoprotein clearance	33	1.44e-01	2.62e-01	0.17700	-1.75e-01	-2.70e-02	8.25e-02	7.89e-01
Regulation of PTEN gene transcription	59	2.15e-02	6.27e-02	0.17600	-6.41e-02	-1.64e-01	3.94e-01	2.94e-02
RHOBTB2 GTPase cycle	23	3.96e-01	5.40e-01	0.17600	-1.64e-01	6.44e-02	1.74e-01	5.93e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.24e-01	2.39e-01	0.17600	2.58e-02	1.74e-01	7.89e-01	7.09e-02
Synthesis of PIPs at the late endosome membrane	11	4.63e-01	5.98e-01	0.17600	1.03e-01	1.42e-01	5.53e-01	4.14e-01
Phospholipase C-mediated cascade: FGFR1	8	6.12e-01	7.25e-01	0.17600	4.35e-02	1.70e-01	8.31e-01	4.04e-01
SHC-mediated cascade:FGFR1	13	4.78e-01	6.11e-01	0.17600	2.02e-02	1.75e-01	9.00e-01	2.76e-01
Regulation of TP53 Degradation	35	2.73e-01	4.17e-01	0.17600	-1.54e-01	8.47e-02	1.15e-01	3.86e-01
Notch-HLH transcription pathway	28	3.57e-01	4.99e-01	0.17500	8.67e-02	-1.53e-01	4.27e-01	1.62e-01
Prolactin receptor signaling	12	4.29e-01	5.71e-01	0.17500	-1.21e-01	-1.26e-01	4.66e-01	4.49e-01
Regulation of HSF1-mediated heat shock response	79	5.93e-03	2.19e-02	0.17500	-1.61e-01	-6.84e-02	1.34e-02	2.93e-01
Signaling by FGFR4	32	2.34e-01	3.70e-01	0.17500	-3.22e-02	1.72e-01	7.52e-01	9.28e-02
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	7.65e-01	8.42e-01	0.17500	-7.97e-03	-1.74e-01	9.75e-01	4.99e-01
TRAF6 mediated NF-kB activation	23	4.59e-01	5.94e-01	0.17400	1.27e-01	-1.19e-01	2.90e-01	3.23e-01
Hedgehog ‘off’ state	91	1.64e-02	5.04e-02	0.17400	-1.71e-01	3.17e-02	4.72e-03	6.02e-01
Gene Silencing by RNA	87	1.34e-02	4.30e-02	0.17400	-1.74e-01	9.66e-03	5.04e-03	8.76e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	4.73e-01	6.07e-01	0.17400	1.46e-01	9.46e-02	4.01e-01	5.87e-01
Maturation of protein 3a 9683673	9	7.27e-01	8.18e-01	0.17400	9.33e-02	-1.47e-01	6.28e-01	4.45e-01
Maturation of protein 3a 9694719	9	7.27e-01	8.18e-01	0.17400	9.33e-02	-1.47e-01	6.28e-01	4.45e-01
Surfactant metabolism	21	4.90e-01	6.20e-01	0.17400	-1.13e-01	1.33e-01	3.71e-01	2.93e-01
Post-translational modification: synthesis of GPI-anchored proteins	59	1.79e-02	5.38e-02	0.17400	-1.41e-01	-1.02e-01	6.12e-02	1.77e-01
Signaling by FGFR3	32	2.19e-01	3.53e-01	0.17300	-1.80e-02	1.72e-01	8.60e-01	9.16e-02
Acyl chain remodeling of CL	5	8.10e-01	8.80e-01	0.17300	1.67e-01	-4.37e-02	5.18e-01	8.66e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.16e-01	2.29e-01	0.17200	-1.64e-01	-4.96e-02	8.81e-02	6.07e-01
Signaling by BRAF and RAF1 fusions	60	1.32e-01	2.49e-01	0.17100	-1.41e-01	9.70e-02	5.86e-02	1.94e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	6.26e-01	7.39e-01	0.17100	9.85e-02	-1.40e-01	5.24e-01	3.66e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	3.89e-01	5.32e-01	0.17000	-1.08e-01	1.32e-01	3.14e-01	2.20e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	1.58e-01	2.80e-01	0.17000	-6.68e-02	1.56e-01	4.14e-01	5.57e-02
ER to Golgi Anterograde Transport	145	9.64e-03	3.27e-02	0.17000	-1.29e-01	1.10e-01	7.44e-03	2.18e-02
MET activates PTK2 signaling	23	4.58e-01	5.93e-01	0.16900	-8.67e-02	1.46e-01	4.72e-01	2.27e-01
Fatty acid metabolism	155	1.18e-04	6.86e-04	0.16900	-1.61e-01	-5.14e-02	5.24e-04	2.70e-01
Rap1 signalling	14	4.53e-01	5.89e-01	0.16900	4.05e-02	1.64e-01	7.93e-01	2.87e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	2.58e-01	3.99e-01	0.16900	1.53e-01	7.10e-02	2.13e-01	5.64e-01
Signaling by PDGFRA extracellular domain mutants	12	5.36e-01	6.63e-01	0.16900	1.68e-01	1.68e-02	3.13e-01	9.20e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	5.36e-01	6.63e-01	0.16900	1.68e-01	1.68e-02	3.13e-01	9.20e-01
Transport of the SLBP Dependant Mature mRNA	36	9.54e-02	1.96e-01	0.16900	-1.13e-01	-1.25e-01	2.40e-01	1.93e-01
Peptide ligand-binding receptors	101	3.47e-03	1.41e-02	0.16900	4.01e-02	1.64e-01	4.86e-01	4.43e-03
Vitamin B5 (pantothenate) metabolism	20	2.94e-01	4.38e-01	0.16900	-6.99e-02	-1.53e-01	5.88e-01	2.35e-01
NS1 Mediated Effects on Host Pathways	40	9.91e-02	2.02e-01	0.16900	-4.95e-02	-1.61e-01	5.88e-01	7.79e-02
NRAGE signals death through JNK	52	1.78e-01	3.03e-01	0.16900	1.43e-01	-8.98e-02	7.52e-02	2.63e-01
Signalling to ERKs	32	2.02e-01	3.32e-01	0.16800	8.73e-03	1.68e-01	9.32e-01	9.96e-02
Phosphate bond hydrolysis by NTPDase proteins	5	7.87e-01	8.61e-01	0.16800	-9.09e-05	-1.68e-01	1.00e+00	5.16e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	4.92e-01	6.21e-01	0.16700	9.45e-02	-1.38e-01	4.43e-01	2.62e-01
Reproduction	85	3.45e-02	9.19e-02	0.16700	-1.62e-01	4.14e-02	9.81e-03	5.10e-01
Defective RIPK1-mediated regulated necrosis	7	7.46e-01	8.30e-01	0.16700	2.99e-02	-1.64e-01	8.91e-01	4.51e-01
Erythropoietin activates RAS	13	4.86e-01	6.18e-01	0.16700	1.62e-01	4.14e-02	3.12e-01	7.96e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	2.81e-01	4.23e-01	0.16700	-1.67e-01	1.58e-03	1.34e-01	9.89e-01
Interferon gamma signaling	90	1.41e-02	4.45e-02	0.16700	-7.15e-04	-1.67e-01	9.91e-01	6.26e-03
Synthesis of IP2, IP, and Ins in the cytosol	13	6.30e-01	7.41e-01	0.16700	1.53e-01	-6.49e-02	3.38e-01	6.85e-01
Insulin receptor signalling cascade	40	8.37e-02	1.79e-01	0.16600	8.93e-02	1.40e-01	3.28e-01	1.24e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	6.88e-01	7.89e-01	0.16600	-1.64e-01	2.93e-02	3.95e-01	8.79e-01
PTEN Regulation	127	1.43e-03	6.47e-03	0.16600	-1.64e-01	-2.44e-02	1.37e-03	6.36e-01
O-linked glycosylation	85	2.32e-02	6.66e-02	0.16600	1.65e-01	-1.26e-02	8.39e-03	8.41e-01
Disease	1633	1.85e-26	8.74e-25	0.16600	-1.61e-01	4.10e-02	2.38e-27	5.79e-03
Beta-catenin independent WNT signaling	126	1.72e-02	5.21e-02	0.16500	-1.43e-01	8.36e-02	5.73e-03	1.05e-01
Histidine catabolism	7	7.32e-01	8.23e-01	0.16500	1.65e-01	-9.72e-03	4.50e-01	9.64e-01
Diseases associated with surfactant metabolism	6	8.24e-01	8.92e-01	0.16500	-8.53e-02	1.41e-01	7.17e-01	5.49e-01
Establishment of Sister Chromatid Cohesion	11	5.92e-01	7.04e-01	0.16500	1.65e-01	6.55e-03	3.44e-01	9.70e-01
Transcriptional regulation by RUNX1	170	5.96e-03	2.19e-02	0.16500	-1.12e-01	1.21e-01	1.17e-02	6.45e-03
Adipogenesis	96	5.52e-02	1.31e-01	0.16500	1.19e-01	-1.15e-01	4.48e-02	5.20e-02
SUMOylation of DNA damage response and repair proteins	77	1.04e-02	3.47e-02	0.16500	-7.58e-02	-1.46e-01	2.50e-01	2.63e-02
Impaired BRCA2 binding to PALB2	24	3.43e-01	4.86e-01	0.16500	-1.64e-01	8.05e-03	1.63e-01	9.46e-01
Diseases of mitotic cell cycle	38	1.16e-01	2.29e-01	0.16400	-1.54e-01	-5.81e-02	1.01e-01	5.36e-01
Apoptotic cleavage of cellular proteins	35	2.50e-01	3.90e-01	0.16400	-3.33e-02	1.61e-01	7.33e-01	9.96e-02
Cell-Cell communication	114	2.24e-02	6.50e-02	0.16400	1.48e-01	-7.15e-02	6.39e-03	1.87e-01
PIWI-interacting RNA (piRNA) biogenesis	23	2.54e-01	3.94e-01	0.16400	-1.41e-01	-8.38e-02	2.43e-01	4.86e-01
activated TAK1 mediates p38 MAPK activation	23	4.98e-01	6.27e-01	0.16400	-1.01e-01	1.29e-01	4.02e-01	2.84e-01
Synthesis of substrates in N-glycan biosythesis	59	8.05e-02	1.74e-01	0.16300	-1.63e-01	1.43e-02	3.05e-02	8.49e-01
Circadian Clock	67	1.08e-01	2.16e-01	0.16300	1.48e-01	-7.00e-02	3.65e-02	3.22e-01
Formation of annular gap junctions	10	7.23e-01	8.16e-01	0.16300	-1.45e-01	7.60e-02	4.29e-01	6.77e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	33	1.51e-01	2.70e-01	0.16300	6.84e-02	1.48e-01	4.97e-01	1.40e-01
SHC1 events in EGFR signaling	12	5.05e-01	6.32e-01	0.16300	1.50e-01	6.52e-02	3.69e-01	6.96e-01
HDACs deacetylate histones	45	1.06e-01	2.13e-01	0.16300	-1.61e-01	-2.47e-02	6.17e-02	7.74e-01
Metabolism of vitamins and cofactors	166	6.28e-05	3.92e-04	0.16300	-1.41e-01	-8.10e-02	1.70e-03	7.18e-02
Erythropoietin activates STAT5	6	7.64e-01	8.42e-01	0.16300	5.15e-04	-1.63e-01	9.98e-01	4.91e-01
Potassium Channels	64	5.91e-02	1.37e-01	0.16200	1.62e-01	-3.39e-03	2.47e-02	9.63e-01
RHOG GTPase cycle	71	7.15e-02	1.58e-01	0.16200	-4.02e-02	1.57e-01	5.58e-01	2.22e-02
Neutrophil degranulation	458	7.31e-07	6.11e-06	0.16200	-7.88e-02	1.41e-01	3.85e-03	2.14e-07
Zinc influx into cells by the SLC39 gene family	9	6.68e-01	7.72e-01	0.16200	1.49e-03	1.62e-01	9.94e-01	4.01e-01
Transport and synthesis of PAPS	6	7.68e-01	8.43e-01	0.16100	-1.61e-01	1.46e-03	4.94e-01	9.95e-01
Transport of the SLBP independent Mature mRNA	35	1.29e-01	2.45e-01	0.16100	-8.96e-02	-1.34e-01	3.59e-01	1.70e-01
G0 and Early G1	27	3.62e-01	5.04e-01	0.16100	-1.57e-01	3.51e-02	1.58e-01	7.52e-01
L1CAM interactions	100	2.85e-02	7.90e-02	0.16000	-4.34e-02	1.54e-01	4.53e-01	7.78e-03
ROS and RNS production in phagocytes	30	4.12e-01	5.56e-01	0.16000	-8.87e-02	1.33e-01	4.00e-01	2.07e-01
Activation of gene expression by SREBF (SREBP)	42	2.89e-01	4.33e-01	0.16000	1.33e-01	-8.81e-02	1.35e-01	3.23e-01
Metabolism of water-soluble vitamins and cofactors	115	1.36e-03	6.19e-03	0.15900	-1.00e-01	-1.23e-01	6.36e-02	2.23e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	43	9.14e-02	1.90e-01	0.15900	-1.38e-01	-7.85e-02	1.18e-01	3.73e-01
SUMOylation of transcription factors	16	3.99e-01	5.43e-01	0.15900	-1.23e-01	-9.98e-02	3.93e-01	4.90e-01
Cellular response to heat stress	94	5.71e-03	2.14e-02	0.15800	-1.39e-01	-7.52e-02	1.95e-02	2.08e-01
Deadenylation of mRNA	22	5.14e-01	6.42e-01	0.15800	-1.39e-01	7.42e-02	2.58e-01	5.47e-01
IRAK2 mediated activation of TAK1 complex	10	6.65e-01	7.71e-01	0.15700	-1.57e-01	7.07e-03	3.90e-01	9.69e-01
TNFR1-induced NF-kappa-B signaling pathway	32	4.14e-01	5.58e-01	0.15700	1.06e-01	-1.16e-01	2.99e-01	2.56e-01
Signaling by MAPK mutants	6	7.65e-01	8.42e-01	0.15700	-1.39e-02	-1.57e-01	9.53e-01	5.07e-01
Cardiac conduction	89	3.35e-02	9.00e-02	0.15700	1.56e-01	-2.03e-02	1.11e-02	7.41e-01
Regulation of TP53 Activity through Acetylation	29	4.50e-01	5.88e-01	0.15700	1.01e-01	-1.19e-01	3.44e-01	2.66e-01
Ca2+ pathway	58	6.72e-02	1.51e-01	0.15700	1.54e-01	2.63e-02	4.19e-02	7.29e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	2.75e-01	4.19e-01	0.15600	-1.53e-01	3.14e-02	1.12e-01	7.44e-01
GRB2 events in EGFR signaling	11	5.64e-01	6.81e-01	0.15600	1.43e-01	6.31e-02	4.13e-01	7.17e-01
GPVI-mediated activation cascade	33	1.61e-01	2.83e-01	0.15600	9.65e-02	1.22e-01	3.37e-01	2.24e-01
SLC15A4:TASL-dependent IRF5 activation	6	8.42e-01	8.99e-01	0.15500	-7.59e-02	1.35e-01	7.48e-01	5.67e-01
ISG15 antiviral mechanism	72	3.10e-02	8.41e-02	0.15500	-1.49e-01	-4.33e-02	2.93e-02	5.25e-01
SUMOylation of ubiquitinylation proteins	39	1.24e-01	2.39e-01	0.15400	-1.24e-01	-9.04e-02	1.79e-01	3.29e-01
Keratinization	37	2.37e-01	3.75e-01	0.15300	-6.27e-03	1.53e-01	9.47e-01	1.07e-01
Signaling by PDGF	50	6.79e-02	1.52e-01	0.15300	1.14e-01	1.02e-01	1.63e-01	2.10e-01
Aquaporin-mediated transport	38	1.65e-01	2.89e-01	0.15300	4.32e-02	1.47e-01	6.45e-01	1.17e-01
Interleukin-1 family signaling	127	3.73e-02	9.76e-02	0.15300	-1.07e-01	1.10e-01	3.78e-02	3.30e-02
Glucagon signaling in metabolic regulation	26	2.57e-01	3.98e-01	0.15200	8.44e-02	1.27e-01	4.56e-01	2.63e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	2.62e-04	1.40e-03	0.15200	-1.42e-01	5.27e-02	4.90e-05	1.33e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	7.46e-01	8.30e-01	0.15100	-8.32e-02	1.26e-01	6.33e-01	4.68e-01
Recruitment of NuMA to mitotic centrosomes	88	2.88e-02	7.96e-02	0.15100	-1.51e-01	-8.15e-03	1.43e-02	8.95e-01
Gap junction trafficking and regulation	30	4.09e-01	5.54e-01	0.15100	-5.49e-02	1.41e-01	6.03e-01	1.82e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	4.88e-01	6.18e-01	0.15100	-9.53e-02	1.17e-01	3.83e-01	2.84e-01
Mitotic Prometaphase	193	2.49e-03	1.05e-02	0.15100	-1.44e-01	4.38e-02	5.42e-04	2.94e-01
Synthesis of pyrophosphates in the cytosol	8	6.80e-01	7.83e-01	0.15100	-5.77e-02	-1.39e-01	7.77e-01	4.95e-01
FRS-mediated FGFR3 signaling	12	5.80e-01	6.94e-01	0.15100	3.92e-02	1.45e-01	8.14e-01	3.83e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	2.47e-01	3.87e-01	0.15000	-1.49e-01	-1.53e-02	1.32e-01	8.77e-01
TGF-beta receptor signaling activates SMADs	45	3.23e-01	4.65e-01	0.15000	-1.12e-01	1.00e-01	1.96e-01	2.44e-01
Biological oxidations	146	7.37e-03	2.60e-02	0.15000	-1.48e-01	2.59e-02	2.05e-03	5.89e-01
TNFs bind their physiological receptors	25	4.85e-01	6.17e-01	0.14900	5.55e-02	-1.39e-01	6.31e-01	2.30e-01
Cyclin D associated events in G1	47	1.38e-01	2.55e-01	0.14900	-1.47e-01	-2.46e-02	8.12e-02	7.70e-01
G1 Phase	47	1.38e-01	2.55e-01	0.14900	-1.47e-01	-2.46e-02	8.12e-02	7.70e-01
RAB geranylgeranylation	61	2.13e-01	3.45e-01	0.14900	-8.69e-02	1.21e-01	2.40e-01	1.02e-01
Signaling by Hippo	18	4.18e-01	5.60e-01	0.14900	6.75e-02	1.33e-01	6.20e-01	3.29e-01
RNA polymerase II transcribes snRNA genes	71	4.91e-02	1.19e-01	0.14900	-1.46e-01	-2.80e-02	3.33e-02	6.83e-01
Free fatty acids regulate insulin secretion	10	7.06e-01	8.01e-01	0.14800	1.48e-01	-1.52e-02	4.19e-01	9.34e-01
Resolution of D-Loop Structures	35	2.55e-01	3.96e-01	0.14800	-1.48e-01	-1.03e-02	1.31e-01	9.16e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	6.22e-01	7.36e-01	0.14800	-8.72e-02	1.20e-01	5.11e-01	3.67e-01
EPHB-mediated forward signaling	40	3.75e-01	5.17e-01	0.14800	-9.27e-02	1.15e-01	3.10e-01	2.08e-01
PKR-mediated signaling	67	1.59e-01	2.81e-01	0.14700	-1.35e-01	6.00e-02	5.65e-02	3.96e-01
Tight junction interactions	17	4.40e-01	5.80e-01	0.14700	-1.25e-01	-7.70e-02	3.70e-01	5.83e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	3.35e-01	4.77e-01	0.14700	5.50e-02	1.36e-01	6.41e-01	2.49e-01
ADORA2B mediated anti-inflammatory cytokines production	36	2.75e-01	4.19e-01	0.14700	-4.43e-03	1.47e-01	9.63e-01	1.28e-01
Transcriptional regulation of white adipocyte differentiation	77	1.56e-01	2.78e-01	0.14600	1.16e-01	-8.85e-02	7.80e-02	1.79e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	1.32e-01	2.49e-01	0.14600	-1.19e-01	-8.46e-02	1.83e-01	3.43e-01
MTOR signalling	39	3.37e-01	4.79e-01	0.14500	-1.36e-01	5.06e-02	1.40e-01	5.84e-01
Antiviral mechanism by IFN-stimulated genes	140	5.92e-03	2.19e-02	0.14500	-1.45e-01	-4.83e-03	2.99e-03	9.21e-01
Nuclear Pore Complex (NPC) Disassembly	36	2.10e-01	3.42e-01	0.14500	-4.57e-02	-1.38e-01	6.35e-01	1.52e-01
Signaling by FGFR1 in disease	32	2.41e-01	3.80e-01	0.14500	1.35e-01	5.36e-02	1.86e-01	6.00e-01
Class I MHC mediated antigen processing & presentation	344	1.53e-04	8.64e-04	0.14500	-1.30e-01	6.50e-02	3.52e-05	3.83e-02
TCR signaling	110	1.12e-02	3.72e-02	0.14400	-1.41e-01	-3.28e-02	1.08e-02	5.52e-01
Membrane Trafficking	577	2.43e-06	1.88e-05	0.14400	-1.06e-01	9.66e-02	1.29e-05	7.34e-05
GPER1 signaling	38	3.62e-01	5.04e-01	0.14300	-5.21e-02	1.33e-01	5.78e-01	1.54e-01
Signaling by NOTCH	175	1.01e-02	3.41e-02	0.14300	-1.33e-01	5.36e-02	2.48e-03	2.21e-01
RAC1 GTPase cycle	173	4.98e-03	1.90e-02	0.14300	1.41e-01	-2.38e-02	1.38e-03	5.89e-01
HDR through Single Strand Annealing (SSA)	37	1.77e-01	3.01e-01	0.14300	-9.80e-02	-1.04e-01	3.02e-01	2.74e-01
Signaling by PDGFR in disease	19	5.48e-01	6.70e-01	0.14300	1.42e-01	-1.77e-02	2.86e-01	8.93e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	86	2.09e-02	6.12e-02	0.14200	1.20e-01	7.56e-02	5.40e-02	2.25e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	4.54e-01	5.89e-01	0.14200	-4.60e-02	-1.34e-01	7.29e-01	3.11e-01
Activation of Matrix Metalloproteinases	22	3.63e-01	5.05e-01	0.14200	9.59e-02	1.04e-01	4.36e-01	3.96e-01
Nicotinamide salvaging	15	7.05e-01	8.01e-01	0.14200	-7.75e-02	1.18e-01	6.03e-01	4.27e-01
Degradation of the extracellular matrix	99	1.26e-02	4.07e-02	0.14100	1.20e-01	7.37e-02	3.87e-02	2.05e-01
Oxidative Stress Induced Senescence	77	1.56e-01	2.78e-01	0.14100	-1.25e-01	6.55e-02	5.82e-02	3.21e-01
Nephron development	5	8.94e-01	9.28e-01	0.14100	8.71e-02	-1.11e-01	7.36e-01	6.68e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	7.45e-01	8.30e-01	0.14100	1.30e-01	5.43e-02	5.52e-01	8.03e-01
Assembly and cell surface presentation of NMDA receptors	34	3.24e-01	4.66e-01	0.14100	1.41e-01	-3.18e-03	1.56e-01	9.74e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	7.64e-01	8.42e-01	0.14000	6.02e-02	-1.26e-01	7.30e-01	4.68e-01
Defective B4GALT7 causes EDS, progeroid type	11	6.38e-01	7.46e-01	0.14000	-1.31e-01	-4.82e-02	4.51e-01	7.82e-01
Cilium Assembly	186	4.56e-04	2.31e-03	0.14000	-5.46e-02	-1.29e-01	1.99e-01	2.44e-03
Interleukin-12 family signaling	53	2.95e-01	4.38e-01	0.14000	-1.20e-01	7.20e-02	1.31e-01	3.64e-01
Negative regulation of the PI3K/AKT network	93	1.79e-02	5.38e-02	0.14000	1.19e-01	7.24e-02	4.67e-02	2.28e-01
Cytosolic sensors of pathogen-associated DNA	63	1.44e-01	2.62e-01	0.13900	-1.38e-01	1.20e-02	5.77e-02	8.69e-01
SUMO E3 ligases SUMOylate target proteins	161	7.01e-03	2.50e-02	0.13900	1.08e-02	-1.38e-01	8.13e-01	2.46e-03
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	1.24e-01	2.39e-01	0.13800	-5.21e-02	1.28e-01	4.07e-01	4.16e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	1.24e-01	2.39e-01	0.13800	-5.21e-02	1.28e-01	4.07e-01	4.16e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	1.24e-01	2.39e-01	0.13800	-5.21e-02	1.28e-01	4.07e-01	4.16e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	11	6.80e-01	7.83e-01	0.13800	-1.37e-01	-1.66e-02	4.32e-01	9.24e-01
Centrosome maturation	81	3.48e-02	9.22e-02	0.13800	-1.21e-01	-6.51e-02	5.93e-02	3.11e-01
Recruitment of mitotic centrosome proteins and complexes	81	3.48e-02	9.22e-02	0.13800	-1.21e-01	-6.51e-02	5.93e-02	3.11e-01
cGMP effects	12	7.77e-01	8.52e-01	0.13700	-1.01e-01	9.35e-02	5.46e-01	5.75e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	5.46e-01	6.69e-01	0.13700	-9.50e-02	-9.91e-02	5.38e-01	5.21e-01
Regulation of insulin secretion	63	1.25e-01	2.39e-01	0.13700	1.37e-01	6.13e-03	5.98e-02	9.33e-01
GRB2 events in ERBB2 signaling	11	6.90e-01	7.90e-01	0.13700	1.37e-01	1.03e-02	4.32e-01	9.53e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	6.59e-01	7.66e-01	0.13700	3.76e-02	-1.32e-01	7.94e-01	3.62e-01
Cytoprotection by HMOX1	53	3.00e-01	4.44e-01	0.13700	-6.42e-02	1.21e-01	4.19e-01	1.28e-01
Sensory Perception	197	2.46e-04	1.32e-03	0.13600	9.62e-02	9.63e-02	1.99e-02	1.98e-02
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	8.40e-01	8.99e-01	0.13500	-4.17e-02	1.29e-01	8.49e-01	5.55e-01
Semaphorin interactions	56	2.00e-01	3.30e-01	0.13500	-1.48e-02	1.34e-01	8.48e-01	8.21e-02
Negative regulators of DDX58/IFIH1 signaling	34	2.79e-01	4.23e-01	0.13500	-1.28e-01	-4.27e-02	1.96e-01	6.67e-01
Regulation of lipid metabolism by PPARalpha	107	9.12e-02	1.90e-01	0.13500	5.99e-02	-1.21e-01	2.84e-01	3.07e-02
SUMOylation	167	6.24e-03	2.28e-02	0.13500	2.21e-03	-1.35e-01	9.61e-01	2.66e-03
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	59	2.30e-01	3.66e-01	0.13500	-3.89e-02	1.29e-01	6.06e-01	8.67e-02
Transcriptional Regulation by TP53	346	8.07e-05	4.87e-04	0.13400	-1.33e-01	2.00e-02	2.15e-05	5.23e-01
Glycosphingolipid metabolism	46	3.98e-01	5.42e-01	0.13400	-9.64e-02	9.34e-02	2.58e-01	2.73e-01
HDL remodeling	6	8.32e-01	8.94e-01	0.13400	-1.34e-01	-6.21e-04	5.70e-01	9.98e-01
Downregulation of ERBB2:ERBB3 signaling	12	6.16e-01	7.29e-01	0.13400	-1.10e-01	-7.56e-02	5.08e-01	6.50e-01
Synthesis of IP3 and IP4 in the cytosol	22	5.80e-01	6.94e-01	0.13400	1.28e-01	-3.77e-02	2.98e-01	7.59e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	50	1.32e-01	2.48e-01	0.13400	1.06e-01	8.08e-02	1.93e-01	3.23e-01
Regulation of FZD by ubiquitination	16	5.39e-01	6.65e-01	0.13400	1.20e-01	5.78e-02	4.04e-01	6.89e-01
Inositol phosphate metabolism	42	4.32e-01	5.74e-01	0.13400	8.62e-02	-1.02e-01	3.34e-01	2.53e-01
Regulation of PLK1 Activity at G2/M Transition	87	4.04e-02	1.03e-01	0.13300	-1.26e-01	-4.50e-02	4.29e-02	4.68e-01
O-linked glycosylation of mucins	47	1.97e-01	3.26e-01	0.13300	1.30e-01	2.88e-02	1.23e-01	7.32e-01
Impaired BRCA2 binding to RAD51	35	2.47e-01	3.87e-01	0.13200	-9.48e-02	-9.19e-02	3.32e-01	3.47e-01
Keratan sulfate biosynthesis	20	6.64e-01	7.71e-01	0.13200	1.12e-01	-6.89e-02	3.84e-01	5.94e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	6.78e-01	7.82e-01	0.13200	-7.15e-02	-1.11e-01	6.95e-01	5.45e-01
Interleukin-12 signaling	44	3.75e-01	5.17e-01	0.13200	-1.22e-01	4.96e-02	1.62e-01	5.69e-01
Fatty acyl-CoA biosynthesis	35	5.00e-01	6.28e-01	0.13100	-7.54e-02	1.08e-01	4.40e-01	2.70e-01
Gain-of-function MRAS complexes activate RAF signaling	8	8.57e-01	9.09e-01	0.13100	8.86e-02	-9.70e-02	6.64e-01	6.35e-01
SHOC2 M1731 mutant abolishes MRAS complex function	8	8.57e-01	9.09e-01	0.13100	8.86e-02	-9.70e-02	6.64e-01	6.35e-01
Signaling by MRAS-complex mutants	8	8.57e-01	9.09e-01	0.13100	8.86e-02	-9.70e-02	6.64e-01	6.35e-01
Kinesins	51	3.43e-01	4.86e-01	0.13100	-5.99e-02	1.17e-01	4.59e-01	1.50e-01
Endogenous sterols	18	6.92e-01	7.93e-01	0.13100	1.13e-01	-6.52e-02	4.05e-01	6.32e-01
Signaling by NTRK2 (TRKB)	20	4.66e-01	6.01e-01	0.13100	1.11e-01	6.92e-02	3.91e-01	5.92e-01
STAT5 Activation	7	8.27e-01	8.92e-01	0.13100	1.30e-01	-1.24e-02	5.52e-01	9.55e-01
AURKA Activation by TPX2	72	9.26e-02	1.91e-01	0.13000	-1.28e-01	-2.73e-02	6.12e-02	6.89e-01
Striated Muscle Contraction	27	4.15e-01	5.58e-01	0.13000	1.28e-01	2.39e-02	2.49e-01	8.30e-01
Innate Immune System	971	2.38e-08	2.54e-07	0.13000	-8.44e-02	9.87e-02	8.41e-06	1.90e-07
GPCR ligand binding	241	6.49e-04	3.17e-03	0.13000	1.29e-01	1.34e-02	5.53e-04	7.21e-01
FGFR1c ligand binding and activation	8	8.54e-01	9.07e-01	0.12900	-1.11e-01	6.73e-02	5.88e-01	7.42e-01
G alpha (q) signalling events	139	6.93e-03	2.49e-02	0.12900	1.18e-01	5.38e-02	1.67e-02	2.74e-01
Downregulation of ERBB2 signaling	24	4.28e-01	5.70e-01	0.12900	-1.19e-01	-4.96e-02	3.12e-01	6.74e-01
RHOH GTPase cycle	34	3.26e-01	4.67e-01	0.12900	3.28e-02	1.24e-01	7.41e-01	2.10e-01
Organelle biogenesis and maintenance	277	3.31e-05	2.20e-04	0.12800	-9.98e-02	-8.09e-02	4.24e-03	2.06e-02
CS/DS degradation	9	7.39e-01	8.29e-01	0.12800	-1.22e-01	-3.90e-02	5.27e-01	8.39e-01
Cross-presentation of particulate exogenous antigens (phagosomes)	8	8.25e-01	8.92e-01	0.12800	1.25e-01	-2.55e-02	5.39e-01	9.01e-01
Nuclear Events (kinase and transcription factor activation)	54	3.67e-01	5.08e-01	0.12800	1.03e-01	-7.63e-02	1.92e-01	3.32e-01
Defective B3GAT3 causes JDSSDHD	11	6.79e-01	7.83e-01	0.12800	-1.16e-01	-5.32e-02	5.05e-01	7.60e-01
DAP12 signaling	28	3.51e-01	4.94e-01	0.12800	9.44e-02	8.61e-02	3.87e-01	4.30e-01
Plasma lipoprotein assembly	10	7.51e-01	8.33e-01	0.12700	1.27e-01	6.21e-03	4.86e-01	9.73e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	8.29e-01	8.92e-01	0.12700	3.85e-03	-1.27e-01	9.86e-01	5.61e-01
CTLA4 inhibitory signaling	21	5.78e-01	6.92e-01	0.12700	1.27e-01	-8.60e-03	3.16e-01	9.46e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	8.06e-01	8.78e-01	0.12700	-9.45e-02	8.44e-02	5.71e-01	6.13e-01
Neuronal System	276	4.42e-04	2.24e-03	0.12700	1.26e-01	6.71e-03	3.00e-04	8.48e-01
Interferon Signaling	240	1.81e-04	1.00e-03	0.12600	-1.01e-01	-7.61e-02	7.13e-03	4.23e-02
Cell recruitment (pro-inflammatory response)	25	4.16e-01	5.59e-01	0.12600	-1.11e-01	-6.08e-02	3.39e-01	5.99e-01
Purinergic signaling in leishmaniasis infection	25	4.16e-01	5.59e-01	0.12600	-1.11e-01	-6.08e-02	3.39e-01	5.99e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	2.93e-01	4.38e-01	0.12600	5.13e-02	1.15e-01	5.94e-01	2.32e-01
Neurotransmitter release cycle	38	4.26e-01	5.68e-01	0.12600	1.22e-01	-3.18e-02	1.93e-01	7.34e-01
Neurotransmitter receptors and postsynaptic signal transmission	141	6.34e-03	2.30e-02	0.12600	9.93e-02	7.73e-02	4.17e-02	1.13e-01
Metabolism of amine-derived hormones	10	8.21e-01	8.90e-01	0.12600	1.14e-01	-5.34e-02	5.33e-01	7.70e-01
Post-translational protein modification	1243	4.84e-12	9.55e-11	0.12600	-1.21e-01	3.31e-02	6.19e-13	4.94e-02
Energy dependent regulation of mTOR by LKB1-AMPK	27	6.26e-01	7.39e-01	0.12500	-9.24e-02	8.40e-02	4.06e-01	4.50e-01
Regulation of NF-kappa B signaling	18	6.46e-01	7.54e-01	0.12400	-1.23e-01	1.42e-02	3.65e-01	9.17e-01
Heparan sulfate/heparin (HS-GAG) metabolism	40	5.03e-01	6.31e-01	0.12400	-8.53e-02	9.04e-02	3.51e-01	3.23e-01
Sensory processing of sound by inner hair cells of the cochlea	54	3.79e-01	5.22e-01	0.12400	1.04e-01	-6.73e-02	1.84e-01	3.92e-01
Loss of Nlp from mitotic centrosomes	69	1.17e-01	2.30e-01	0.12400	-1.19e-01	-3.45e-02	8.67e-02	6.20e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	1.17e-01	2.30e-01	0.12400	-1.19e-01	-3.45e-02	8.67e-02	6.20e-01
Diseases of metabolism	208	9.22e-03	3.17e-02	0.12400	-1.21e-01	2.33e-02	2.52e-03	5.63e-01
G beta:gamma signalling through PLC beta	17	7.42e-01	8.30e-01	0.12300	-7.01e-02	1.02e-01	6.17e-01	4.69e-01
Presynaptic function of Kainate receptors	17	7.42e-01	8.30e-01	0.12300	-7.01e-02	1.02e-01	6.17e-01	4.69e-01
Signal regulatory protein family interactions	13	7.38e-01	8.28e-01	0.12300	-1.22e-01	1.73e-02	4.46e-01	9.14e-01
G beta:gamma signalling through CDC42	17	7.31e-01	8.22e-01	0.12300	-5.71e-02	1.09e-01	6.83e-01	4.36e-01
MAP kinase activation	63	2.92e-01	4.37e-01	0.12300	-4.62e-02	1.14e-01	5.26e-01	1.18e-01
G beta:gamma signalling through PI3Kgamma	22	5.96e-01	7.09e-01	0.12300	-1.45e-02	1.22e-01	9.06e-01	3.23e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	7.38e-01	8.28e-01	0.12300	-1.22e-01	1.57e-02	4.48e-01	9.22e-01
Respiratory syncytial virus (RSV) attachment and entry	18	5.41e-01	6.66e-01	0.12200	9.05e-02	8.18e-02	5.06e-01	5.48e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	1.26e-01	2.41e-01	0.12200	-7.92e-02	-9.27e-02	2.85e-01	2.11e-01
Cellular Senescence	143	6.47e-02	1.46e-01	0.12200	-1.13e-01	4.50e-02	1.95e-02	3.53e-01
Aspirin ADME	16	7.61e-01	8.40e-01	0.12200	-6.84e-02	1.01e-01	6.36e-01	4.86e-01
Signaling by FGFR2 in disease	33	4.49e-01	5.86e-01	0.12100	-1.21e-01	5.38e-03	2.28e-01	9.57e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	6.31e-01	7.41e-01	0.12100	-2.67e-02	-1.18e-01	8.53e-01	4.13e-01
Regulation of MITF-M-dependent genes involved in pigmentation	37	4.22e-01	5.64e-01	0.12100	1.21e-01	-1.13e-02	2.05e-01	9.06e-01
CD28 dependent PI3K/Akt signaling	22	6.84e-01	7.85e-01	0.12100	1.04e-01	-6.25e-02	4.00e-01	6.12e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	5.74e-01	6.88e-01	0.12100	-4.46e-02	-1.13e-01	7.43e-01	4.09e-01
Cytochrome P450 - arranged by substrate type	38	4.73e-01	6.07e-01	0.12000	1.15e-01	-3.66e-02	2.21e-01	6.96e-01
Assembly of collagen fibrils and other multimeric structures	44	3.00e-01	4.44e-01	0.12000	1.19e-01	1.98e-02	1.73e-01	8.20e-01
Activation of kainate receptors upon glutamate binding	26	4.43e-01	5.82e-01	0.12000	5.41e-02	1.07e-01	6.33e-01	3.45e-01
Evasion by RSV of host interferon responses	20	6.82e-01	7.84e-01	0.12000	3.98e-02	-1.13e-01	7.58e-01	3.82e-01
N-Glycan antennae elongation	13	7.26e-01	8.18e-01	0.12000	1.47e-03	1.20e-01	9.93e-01	4.55e-01
Cellular responses to mechanical stimuli	82	1.92e-01	3.21e-01	0.12000	-3.08e-02	1.16e-01	6.30e-01	7.05e-02
Response of endothelial cells to shear stress	82	1.92e-01	3.21e-01	0.12000	-3.08e-02	1.16e-01	6.30e-01	7.05e-02
RUNX3 regulates CDKN1A transcription	7	8.93e-01	9.28e-01	0.11900	9.55e-02	-7.18e-02	6.62e-01	7.42e-01
Triglyceride catabolism	16	6.68e-01	7.72e-01	0.11900	6.37e-03	1.19e-01	9.65e-01	4.09e-01
Signaling by GPCR	442	5.47e-05	3.43e-04	0.11900	1.19e-01	-1.10e-02	1.90e-05	6.92e-01
RUNX2 regulates genes involved in cell migration	6	9.00e-01	9.30e-01	0.11900	1.07e-01	-5.24e-02	6.50e-01	8.24e-01
RHOB GTPase cycle	65	1.40e-01	2.57e-01	0.11900	4.79e-02	1.09e-01	5.05e-01	1.29e-01
Signaling by Hedgehog	120	1.05e-01	2.11e-01	0.11900	-1.12e-01	3.93e-02	3.36e-02	4.57e-01
Gap junction degradation	11	8.19e-01	8.88e-01	0.11800	-4.20e-02	1.10e-01	8.09e-01	5.28e-01
IRF3-mediated induction of type I IFN	12	8.07e-01	8.79e-01	0.11800	-1.09e-01	4.48e-02	5.14e-01	7.88e-01
PPARA activates gene expression	105	1.58e-01	2.80e-01	0.11800	4.65e-02	-1.08e-01	4.10e-01	5.57e-02
RND2 GTPase cycle	37	5.06e-01	6.34e-01	0.11700	1.11e-01	-3.88e-02	2.43e-01	6.83e-01
Regulation of signaling by NODAL	6	8.64e-01	9.14e-01	0.11700	1.17e-01	6.87e-03	6.19e-01	9.77e-01
Activated point mutants of FGFR2	7	8.80e-01	9.20e-01	0.11700	3.99e-02	-1.10e-01	8.55e-01	6.13e-01
Signaling by FGFR1	42	2.93e-01	4.38e-01	0.11700	4.59e-02	1.08e-01	6.07e-01	2.27e-01
Activated NTRK2 signals through RAS	6	8.42e-01	8.99e-01	0.11700	1.10e-01	4.10e-02	6.42e-01	8.62e-01
RHO GTPases Activate NADPH Oxidases	21	5.54e-01	6.75e-01	0.11700	1.10e-01	3.77e-02	3.81e-01	7.65e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	3.81e-01	5.23e-01	0.11600	-1.07e-01	4.61e-02	1.66e-01	5.51e-01
LDL clearance	18	7.55e-01	8.36e-01	0.11600	-9.67e-02	6.46e-02	4.78e-01	6.35e-01
Formation of WDR5-containing histone-modifying complexes	42	4.98e-01	6.27e-01	0.11600	5.19e-02	-1.04e-01	5.61e-01	2.43e-01
Negative regulation of FLT3	15	6.88e-01	7.89e-01	0.11600	-1.58e-02	-1.15e-01	9.16e-01	4.42e-01
Adaptive Immune System	768	1.33e-05	9.27e-05	0.11500	-9.22e-02	6.94e-02	1.37e-05	1.06e-03
VEGFR2 mediated cell proliferation	18	6.31e-01	7.41e-01	0.11500	-1.13e-01	-2.19e-02	4.05e-01	8.72e-01
Biosynthesis of E-series 18(S)-resolvins	5	8.72e-01	9.16e-01	0.11500	1.09e-01	3.72e-02	6.73e-01	8.85e-01
Signaling by NOTCH3	44	4.78e-01	6.11e-01	0.11500	-4.56e-02	1.05e-01	6.00e-01	2.26e-01
RET signaling	32	4.29e-01	5.70e-01	0.11400	1.09e-01	3.38e-02	2.86e-01	7.41e-01
Transmission across Chemical Synapses	188	5.75e-03	2.14e-02	0.11400	1.04e-01	4.53e-02	1.36e-02	2.84e-01
Hydrolysis of LPC	8	8.90e-01	9.25e-01	0.11300	-6.45e-02	9.25e-02	7.52e-01	6.50e-01
Chondroitin sulfate/dermatan sulfate metabolism	38	5.62e-01	6.80e-01	0.11200	-5.49e-02	9.82e-02	5.58e-01	2.95e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	8.54e-01	9.07e-01	0.11200	-1.36e-02	1.11e-01	9.47e-01	5.85e-01
Effects of PIP2 hydrolysis	24	5.58e-01	6.79e-01	0.11200	1.10e-01	2.22e-02	3.52e-01	8.51e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	38	5.44e-01	6.68e-01	0.11100	-1.03e-01	4.13e-02	2.70e-01	6.60e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	5.44e-01	6.68e-01	0.11100	-1.00e-01	-4.72e-02	4.05e-01	6.95e-01
G alpha (s) signalling events	97	2.34e-01	3.70e-01	0.11100	9.88e-02	-5.00e-02	9.27e-02	3.95e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	6.99e-01	7.97e-01	0.10900	4.41e-02	1.00e-01	7.75e-01	5.17e-01
RAC2 GTPase cycle	86	1.94e-01	3.23e-01	0.10900	1.08e-01	-7.92e-03	8.24e-02	8.99e-01
Transcriptional activation of mitochondrial biogenesis	52	4.99e-01	6.28e-01	0.10800	8.82e-02	-6.24e-02	2.71e-01	4.36e-01
Beta-oxidation of very long chain fatty acids	11	8.62e-01	9.13e-01	0.10800	-5.91e-02	9.00e-02	7.34e-01	6.05e-01
Formation of definitive endoderm	9	7.95e-01	8.68e-01	0.10700	9.36e-02	5.27e-02	6.27e-01	7.84e-01
Gamma-carboxylation of protein precursors	6	9.25e-01	9.50e-01	0.10700	6.60e-02	-8.43e-02	7.80e-01	7.21e-01
FGFR2b ligand binding and activation	6	8.70e-01	9.16e-01	0.10700	1.02e-01	3.18e-02	6.66e-01	8.93e-01
Bacterial Infection Pathways	66	4.33e-01	5.74e-01	0.10700	-7.15e-02	7.92e-02	3.15e-01	2.66e-01
Calcineurin activates NFAT	9	8.34e-01	8.95e-01	0.10600	6.79e-03	1.06e-01	9.72e-01	5.81e-01
TP53 Regulates Transcription of Cell Death Genes	43	5.59e-01	6.79e-01	0.10600	5.09e-02	-9.30e-02	5.64e-01	2.91e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	7.32e-01	8.23e-01	0.10600	8.80e-02	-5.91e-02	4.56e-01	6.17e-01
Zinc transporters	12	8.59e-01	9.10e-01	0.10600	-8.31e-02	6.55e-02	6.18e-01	6.94e-01
Blood group systems biosynthesis	18	6.47e-01	7.54e-01	0.10500	4.73e-02	9.42e-02	7.28e-01	4.89e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	5.21e-01	6.48e-01	0.10500	2.39e-02	1.02e-01	8.21e-01	3.32e-01
RHOF GTPase cycle	39	3.72e-01	5.14e-01	0.10500	7.18e-02	7.68e-02	4.38e-01	4.07e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	5.67e-01	6.83e-01	0.10500	-3.54e-03	1.05e-01	9.73e-01	3.13e-01
PI3K/AKT Signaling in Cancer	85	1.54e-01	2.75e-01	0.10500	1.01e-01	2.87e-02	1.09e-01	6.47e-01
Sensory perception of taste	22	6.12e-01	7.26e-01	0.10500	9.98e-02	3.13e-02	4.18e-01	8.00e-01
FGFR1 mutant receptor activation	25	5.51e-01	6.73e-01	0.10300	8.62e-02	5.65e-02	4.55e-01	6.25e-01
FGFR1 ligand binding and activation	10	8.68e-01	9.16e-01	0.10300	-3.44e-02	9.70e-02	8.51e-01	5.95e-01
CDC42 GTPase cycle	141	3.80e-02	9.87e-02	0.10300	9.00e-02	4.98e-02	6.50e-02	3.08e-01
GPCR downstream signalling	398	1.05e-03	4.90e-03	0.10300	1.03e-01	-4.11e-03	4.33e-04	8.88e-01
A tetrasaccharide linker sequence is required for GAG synthesis	17	7.73e-01	8.49e-01	0.10300	-9.98e-02	2.38e-02	4.76e-01	8.65e-01
RND3 GTPase cycle	36	4.33e-01	5.74e-01	0.10200	8.81e-02	5.21e-02	3.60e-01	5.88e-01
Interleukin-17 signaling	68	3.83e-01	5.26e-01	0.10200	-3.20e-02	9.71e-02	6.48e-01	1.66e-01
Acyl chain remodelling of PC	19	6.98e-01	7.96e-01	0.10200	1.02e-01	9.65e-03	4.43e-01	9.42e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	79	2.88e-01	4.32e-01	0.10100	-1.36e-02	1.00e-01	8.34e-01	1.24e-01
HS-GAG degradation	19	7.23e-01	8.16e-01	0.10100	-1.01e-01	2.45e-03	4.46e-01	9.85e-01
Class A/1 (Rhodopsin-like receptors)	175	2.27e-02	6.57e-02	0.10100	9.27e-02	4.01e-02	3.44e-02	3.60e-01
COPII-mediated vesicle transport	67	4.39e-01	5.79e-01	0.10100	-8.91e-02	4.68e-02	2.07e-01	5.08e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	4.77e-01	6.11e-01	0.10000	4.39e-02	9.00e-02	6.58e-01	3.64e-01
Oncogenic MAPK signaling	76	4.10e-01	5.54e-01	0.09990	-8.54e-02	5.19e-02	1.98e-01	4.34e-01
PI5P Regulates TP53 Acetylation	8	8.69e-01	9.16e-01	0.09960	9.95e-02	4.85e-03	6.26e-01	9.81e-01
Extra-nuclear estrogen signaling	67	4.02e-01	5.46e-01	0.09950	-2.88e-02	9.52e-02	6.83e-01	1.78e-01
Signaling by ALK fusions and activated point mutants	89	3.47e-01	4.89e-01	0.09920	8.74e-02	-4.69e-02	1.54e-01	4.44e-01
Signaling by ALK in cancer	89	3.47e-01	4.89e-01	0.09920	8.74e-02	-4.69e-02	1.54e-01	4.44e-01
Sema3A PAK dependent Axon repulsion	15	7.22e-01	8.16e-01	0.09900	8.61e-02	4.90e-02	5.64e-01	7.43e-01
Deubiquitination	225	8.70e-02	1.84e-01	0.09900	-7.45e-02	6.52e-02	5.41e-02	9.21e-02
FGFR1b ligand binding and activation	5	9.11e-01	9.38e-01	0.09880	1.78e-02	9.72e-02	9.45e-01	7.07e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	8.10e-01	8.81e-01	0.09880	-3.95e-03	9.87e-02	9.80e-01	5.38e-01
Regulation of TP53 Activity	153	8.46e-02	1.80e-01	0.09870	-9.87e-02	3.06e-03	3.52e-02	9.48e-01
Signaling by SCF-KIT	40	4.50e-01	5.87e-01	0.09860	9.37e-02	3.09e-02	3.05e-01	7.35e-01
Signaling by FGFR	73	4.55e-01	5.90e-01	0.09860	-7.25e-02	6.67e-02	2.84e-01	3.24e-01
RHO GTPases activate KTN1	11	7.83e-01	8.58e-01	0.09850	6.43e-02	7.47e-02	7.12e-01	6.68e-01
Attachment and Entry 9694614	14	8.44e-01	9.01e-01	0.09850	4.19e-02	-8.92e-02	7.86e-01	5.63e-01
Ovarian tumor domain proteases	37	4.87e-01	6.18e-01	0.09850	9.50e-02	2.59e-02	3.17e-01	7.85e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	8.21e-01	8.90e-01	0.09850	-9.77e-02	-1.20e-02	5.75e-01	9.45e-01
Glucose metabolism	76	1.87e-01	3.15e-01	0.09820	-7.31e-02	-6.56e-02	2.71e-01	3.23e-01
Biosynthesis of DHA-derived SPMs	15	8.52e-01	9.07e-01	0.09780	7.12e-02	-6.71e-02	6.33e-01	6.53e-01
Metabolism of carbohydrates	241	3.76e-02	9.82e-02	0.09770	-9.51e-02	2.24e-02	1.10e-02	5.49e-01
Respiratory Syncytial Virus Infection Pathway	99	2.12e-01	3.45e-01	0.09740	-9.73e-02	4.09e-03	9.42e-02	9.44e-01
FOXO-mediated transcription of cell cycle genes	15	7.24e-01	8.17e-01	0.09740	7.82e-02	5.81e-02	6.00e-01	6.97e-01
RSV-host interactions	78	1.92e-01	3.21e-01	0.09740	-5.16e-02	-8.26e-02	4.31e-01	2.07e-01
Small interfering RNA (siRNA) biogenesis	9	8.22e-01	8.91e-01	0.09730	6.88e-02	6.87e-02	7.21e-01	7.21e-01
SUMOylation of intracellular receptors	26	7.50e-01	8.32e-01	0.09710	8.25e-02	-5.11e-02	4.66e-01	6.52e-01
Arachidonate metabolism	45	6.15e-01	7.28e-01	0.09690	-5.48e-02	7.99e-02	5.25e-01	3.53e-01
Integration of energy metabolism	88	1.71e-01	2.96e-01	0.09690	8.84e-02	3.97e-02	1.52e-01	5.20e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	4.43e-01	5.82e-01	0.09680	9.63e-02	-9.94e-03	2.17e-01	8.99e-01
Visual phototransduction	60	5.10e-01	6.38e-01	0.09670	-4.69e-02	8.46e-02	5.30e-01	2.57e-01
Listeria monocytogenes entry into host cells	17	8.11e-01	8.81e-01	0.09620	-9.07e-02	3.22e-02	5.17e-01	8.18e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	7.60e-01	8.39e-01	0.09600	-4.28e-03	-9.59e-02	9.76e-01	4.94e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	7.60e-01	8.39e-01	0.09600	-4.28e-03	-9.59e-02	9.76e-01	4.94e-01
FRS-mediated FGFR4 signaling	13	7.63e-01	8.42e-01	0.09530	7.23e-02	6.21e-02	6.52e-01	6.98e-01
Developmental Biology	929	8.67e-05	5.17e-04	0.09520	-7.92e-02	5.29e-02	4.27e-05	6.29e-03
SHC-mediated cascade:FGFR3	10	8.51e-01	9.06e-01	0.09510	6.43e-03	9.49e-02	9.72e-01	6.03e-01
SUMOylation of immune response proteins	12	8.73e-01	9.16e-01	0.09510	3.97e-02	-8.64e-02	8.12e-01	6.04e-01
Anchoring of the basal body to the plasma membrane	97	1.39e-01	2.56e-01	0.09500	-5.43e-02	-7.80e-02	3.56e-01	1.84e-01
Growth hormone receptor signaling	21	6.73e-01	7.77e-01	0.09470	8.84e-02	3.41e-02	4.83e-01	7.87e-01
Acyl chain remodelling of PE	20	7.91e-01	8.64e-01	0.09450	-8.83e-02	3.37e-02	4.94e-01	7.94e-01
Signaling by Non-Receptor Tyrosine Kinases	47	6.29e-01	7.41e-01	0.09420	-6.81e-02	6.51e-02	4.20e-01	4.40e-01
Signaling by PTK6	47	6.29e-01	7.41e-01	0.09420	-6.81e-02	6.51e-02	4.20e-01	4.40e-01
Signaling by TGF-beta Receptor Complex	91	2.83e-01	4.26e-01	0.09420	-1.09e-02	9.35e-02	8.57e-01	1.23e-01
Nuclear Envelope Breakdown	53	3.54e-01	4.97e-01	0.09410	-8.14e-02	-4.72e-02	3.05e-01	5.52e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	19	6.81e-01	7.83e-01	0.09400	6.48e-02	6.80e-02	6.25e-01	6.08e-01
CD28 co-stimulation	33	6.88e-01	7.89e-01	0.09340	8.68e-02	-3.44e-02	3.88e-01	7.32e-01
Pre-NOTCH Expression and Processing	63	3.90e-01	5.33e-01	0.09330	1.48e-03	9.33e-02	9.84e-01	2.00e-01
Sensory processing of sound	58	5.18e-01	6.46e-01	0.09330	8.69e-02	-3.39e-02	2.52e-01	6.55e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	17	8.25e-01	8.92e-01	0.09300	-3.36e-02	8.68e-02	8.11e-01	5.36e-01
TNF signaling	56	5.84e-01	6.98e-01	0.09250	5.94e-02	-7.09e-02	4.42e-01	3.58e-01
Carboxyterminal post-translational modifications of tubulin	34	7.25e-01	8.17e-01	0.09220	-6.84e-02	6.18e-02	4.90e-01	5.33e-01
Biosynthesis of specialized proresolving mediators (SPMs)	17	7.51e-01	8.33e-01	0.09210	8.95e-02	2.21e-02	5.23e-01	8.74e-01
Sialic acid metabolism	28	7.67e-01	8.43e-01	0.09210	6.24e-02	-6.78e-02	5.68e-01	5.35e-01
Nucleotide-like (purinergic) receptors	13	8.85e-01	9.23e-01	0.09180	6.24e-02	-6.74e-02	6.97e-01	6.74e-01
Regulation of TNFR1 signaling	47	6.31e-01	7.41e-01	0.09150	7.77e-02	-4.83e-02	3.57e-01	5.67e-01
FRS-mediated FGFR2 signaling	15	7.85e-01	8.59e-01	0.09150	8.97e-02	1.80e-02	5.48e-01	9.04e-01
ADP signalling through P2Y purinoceptor 1	21	8.00e-01	8.72e-01	0.09110	-3.50e-02	8.40e-02	7.81e-01	5.05e-01
FasL/ CD95L signaling	5	9.09e-01	9.38e-01	0.09090	6.32e-02	6.54e-02	8.07e-01	8.00e-01
Nuclear signaling by ERBB4	24	6.40e-01	7.47e-01	0.09020	-6.83e-02	-5.89e-02	5.63e-01	6.17e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	108	1.94e-01	3.23e-01	0.09020	-1.31e-02	-8.92e-02	8.15e-01	1.09e-01
PP2A-mediated dephosphorylation of key metabolic factors	7	8.87e-01	9.24e-01	0.08990	8.31e-02	3.43e-02	7.03e-01	8.75e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	8.76e-01	9.16e-01	0.08990	-9.37e-03	-8.94e-02	9.61e-01	6.42e-01
Downstream signal transduction	27	7.19e-01	8.13e-01	0.08910	8.82e-02	-1.25e-02	4.28e-01	9.11e-01
Ephrin signaling	18	8.50e-01	9.05e-01	0.08870	5.05e-02	-7.29e-02	7.11e-01	5.92e-01
FGFR2c ligand binding and activation	5	9.56e-01	9.70e-01	0.08860	7.36e-02	-4.93e-02	7.76e-01	8.49e-01
RHOC GTPase cycle	72	3.03e-01	4.45e-01	0.08840	3.43e-02	8.15e-02	6.15e-01	2.32e-01
Pre-NOTCH Transcription and Translation	47	5.19e-01	6.46e-01	0.08820	7.15e-03	8.79e-02	9.32e-01	2.97e-01
Signaling by EGFR in Cancer	23	6.94e-01	7.93e-01	0.08680	8.07e-02	3.21e-02	5.03e-01	7.90e-01
TCF dependent signaling in response to WNT	153	2.81e-01	4.23e-01	0.08650	-5.77e-02	6.45e-02	2.18e-01	1.68e-01
Lysine catabolism	11	8.29e-01	8.92e-01	0.08620	-6.33e-02	-5.85e-02	7.16e-01	7.37e-01
Eicosanoid ligand-binding receptors	13	8.72e-01	9.16e-01	0.08570	-8.33e-02	2.02e-02	6.03e-01	9.00e-01
Ion homeostasis	42	7.06e-01	8.01e-01	0.08540	6.82e-02	-5.15e-02	4.44e-01	5.64e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	8.33e-01	8.95e-01	0.08500	1.72e-03	-8.50e-02	9.91e-01	5.69e-01
Signaling by Activin	14	8.76e-01	9.16e-01	0.08470	-2.90e-02	7.96e-02	8.51e-01	6.06e-01
RUNX2 regulates osteoblast differentiation	21	7.74e-01	8.49e-01	0.08400	8.40e-02	1.99e-03	5.05e-01	9.87e-01
VEGFA-VEGFR2 Pathway	93	4.45e-01	5.83e-01	0.08370	-3.56e-02	7.57e-02	5.53e-01	2.07e-01
RAF activation	33	7.57e-01	8.37e-01	0.08330	-3.86e-02	7.39e-02	7.01e-01	4.63e-01
Loss of Function of TGFBR1 in Cancer	7	9.46e-01	9.65e-01	0.08280	-6.89e-02	4.60e-02	7.52e-01	8.33e-01
Negative regulation of MAPK pathway	42	7.19e-01	8.13e-01	0.08280	-4.76e-02	6.77e-02	5.93e-01	4.47e-01
SHC-mediated cascade:FGFR2	13	8.99e-01	9.30e-01	0.08270	7.22e-02	-4.05e-02	6.52e-01	8.01e-01
Reduction of cytosolic Ca++ levels	9	8.80e-01	9.20e-01	0.08220	2.89e-02	7.69e-02	8.81e-01	6.89e-01
RA biosynthesis pathway	13	8.28e-01	8.92e-01	0.08200	-3.43e-02	-7.45e-02	8.30e-01	6.42e-01
Stimuli-sensing channels	81	5.00e-01	6.28e-01	0.08180	7.55e-02	-3.16e-02	2.40e-01	6.23e-01
Signaling by WNT	241	1.42e-01	2.60e-01	0.08160	-3.67e-02	7.28e-02	3.27e-01	5.15e-02
Muscle contraction	145	1.18e-01	2.31e-01	0.08160	6.96e-02	4.24e-02	1.48e-01	3.78e-01
Regulation of endogenous retroelements	92	2.48e-01	3.89e-01	0.08150	-6.22e-02	-5.26e-02	3.02e-01	3.83e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	7.64e-01	8.42e-01	0.08050	1.23e-02	7.96e-02	9.21e-01	5.18e-01
Signaling by VEGF	100	4.87e-01	6.18e-01	0.08050	-5.88e-02	5.49e-02	3.10e-01	3.42e-01
NOTCH1 Intracellular Domain Regulates Transcription	46	6.81e-01	7.83e-01	0.07980	2.84e-02	-7.46e-02	7.39e-01	3.81e-01
G alpha (12/13) signalling events	68	5.14e-01	6.42e-01	0.07950	7.88e-02	-1.04e-02	2.61e-01	8.82e-01
Death Receptor Signaling	145	3.63e-01	5.05e-01	0.07940	5.33e-02	-5.88e-02	2.68e-01	2.22e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	81	4.55e-01	5.90e-01	0.07930	7.86e-02	-1.04e-02	2.21e-01	8.72e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	8.66e-01	9.15e-01	0.07890	-7.87e-02	-4.97e-03	6.23e-01	9.75e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	9.37e-01	9.59e-01	0.07870	7.87e-02	2.30e-03	7.38e-01	9.92e-01
Scavenging by Class F Receptors	5	9.55e-01	9.70e-01	0.07870	1.41e-02	-7.74e-02	9.56e-01	7.64e-01
FGFR3 ligand binding and activation	5	9.65e-01	9.75e-01	0.07830	6.56e-02	-4.28e-02	8.00e-01	8.68e-01
FGFR3c ligand binding and activation	5	9.65e-01	9.75e-01	0.07830	6.56e-02	-4.28e-02	8.00e-01	8.68e-01
Post-translational protein phosphorylation	70	5.73e-01	6.88e-01	0.07770	-2.67e-02	7.29e-02	7.00e-01	2.91e-01
Gene expression (Transcription)	1413	1.32e-08	1.45e-07	0.07760	-4.73e-02	-6.15e-02	2.91e-03	1.06e-04
Metal ion SLC transporters	19	8.33e-01	8.94e-01	0.07730	-5.81e-03	7.70e-02	9.65e-01	5.61e-01
RAB GEFs exchange GTP for GDP on RABs	89	4.88e-01	6.18e-01	0.07720	-2.38e-02	7.34e-02	6.98e-01	2.31e-01
RHOD GTPase cycle	50	5.47e-01	6.70e-01	0.07700	2.27e-02	7.36e-02	7.82e-01	3.68e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	9.32e-01	9.54e-01	0.07690	7.45e-02	1.92e-02	7.52e-01	9.35e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	9.32e-01	9.54e-01	0.07690	7.45e-02	1.92e-02	7.52e-01	9.35e-01
Platelet homeostasis	69	5.49e-01	6.71e-01	0.07660	-1.46e-02	7.52e-02	8.34e-01	2.80e-01
Transcription of E2F targets under negative control by DREAM complex	19	7.89e-01	8.62e-01	0.07650	-7.03e-02	-3.03e-02	5.96e-01	8.19e-01
Formation of the beta-catenin:TCF transactivating complex	44	7.16e-01	8.11e-01	0.07640	-2.77e-02	7.12e-02	7.50e-01	4.14e-01
FOXO-mediated transcription	58	4.71e-01	6.05e-01	0.07630	4.01e-02	6.50e-02	5.97e-01	3.92e-01
C-type lectin receptors (CLRs)	118	3.25e-01	4.67e-01	0.07630	-7.62e-02	3.98e-03	1.53e-01	9.40e-01
NOD1/2 Signaling Pathway	36	7.06e-01	8.01e-01	0.07630	7.62e-02	-2.64e-03	4.29e-01	9.78e-01
RAF/MAP kinase cascade	226	2.27e-01	3.63e-01	0.07620	-4.48e-02	6.16e-02	2.46e-01	1.11e-01
RNA Polymerase II Transcription	1206	4.10e-07	3.56e-06	0.07610	-3.90e-02	-6.53e-02	2.25e-02	1.33e-04
Toll Like Receptor 4 (TLR4) Cascade	138	3.32e-01	4.74e-01	0.07610	7.30e-02	-2.13e-02	1.38e-01	6.66e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	8.40e-01	8.99e-01	0.07580	-6.80e-02	-3.35e-02	6.59e-01	8.28e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	8.40e-01	8.99e-01	0.07580	-6.80e-02	-3.35e-02	6.59e-01	8.28e-01
Phospholipid metabolism	183	2.14e-01	3.46e-01	0.07540	7.42e-02	-1.37e-02	8.35e-02	7.49e-01
Transport of small molecules	558	3.04e-02	8.27e-02	0.07460	-6.17e-02	4.20e-02	1.28e-02	8.98e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	9.41e-01	9.62e-01	0.07460	-7.44e-03	-7.42e-02	9.75e-01	7.53e-01
Generic Transcription Pathway	1088	7.80e-06	5.65e-05	0.07430	-2.33e-02	-7.06e-02	1.95e-01	8.38e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	624	1.71e-02	5.21e-02	0.07430	-3.50e-02	6.56e-02	1.36e-01	5.16e-03
Lewis blood group biosynthesis	14	8.40e-01	8.99e-01	0.07370	5.55e-02	4.85e-02	7.19e-01	7.53e-01
MAPK1/MAPK3 signaling	232	2.32e-01	3.68e-01	0.07370	-3.93e-02	6.24e-02	3.02e-01	1.02e-01
Glycolysis	68	4.71e-01	6.05e-01	0.07340	-6.95e-02	-2.36e-02	3.22e-01	7.36e-01
Acyl chain remodelling of PS	14	8.76e-01	9.16e-01	0.07300	7.28e-02	4.74e-03	6.37e-01	9.76e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	8.74e-01	9.16e-01	0.07260	-2.85e-02	-6.68e-02	8.64e-01	6.89e-01
alpha-linolenic acid (ALA) metabolism	12	8.74e-01	9.16e-01	0.07260	-2.85e-02	-6.68e-02	8.64e-01	6.89e-01
Extracellular matrix organization	222	8.03e-02	1.74e-01	0.07260	3.22e-02	6.51e-02	4.08e-01	9.46e-02
Gastrin-CREB signalling pathway via PKC and MAPK	14	8.45e-01	9.02e-01	0.07250	5.44e-02	4.79e-02	7.25e-01	7.56e-01
CaMK IV-mediated phosphorylation of CREB	9	9.46e-01	9.65e-01	0.07250	3.91e-02	-6.10e-02	8.39e-01	7.51e-01
RIPK1-mediated regulated necrosis	31	7.05e-01	8.01e-01	0.07230	6.54e-02	3.08e-02	5.29e-01	7.67e-01
Regulation of necroptotic cell death	31	7.05e-01	8.01e-01	0.07230	6.54e-02	3.08e-02	5.29e-01	7.67e-01
RUNX2 regulates bone development	26	7.46e-01	8.30e-01	0.07010	4.92e-02	4.99e-02	6.64e-01	6.60e-01
Serine biosynthesis	8	9.17e-01	9.42e-01	0.07000	3.43e-02	6.11e-02	8.67e-01	7.65e-01
Sensory processing of sound by outer hair cells of the cochlea	41	6.35e-01	7.44e-01	0.07000	5.66e-02	4.11e-02	5.31e-01	6.49e-01
SHC1 events in ERBB2 signaling	17	8.27e-01	8.92e-01	0.06970	4.66e-02	5.19e-02	7.40e-01	7.11e-01
Integrin cell surface interactions	68	4.74e-01	6.07e-01	0.06930	4.82e-02	4.98e-02	4.92e-01	4.78e-01
STING mediated induction of host immune responses	15	8.53e-01	9.07e-01	0.06910	-3.47e-02	-5.98e-02	8.16e-01	6.89e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	8.93e-01	9.28e-01	0.06910	6.47e-02	-2.41e-02	6.34e-01	8.60e-01
Immune System	1841	1.38e-04	7.87e-04	0.06880	-4.81e-02	4.92e-02	6.29e-04	4.63e-04
Toll-like Receptor Cascades	162	4.26e-01	5.69e-01	0.06880	5.22e-02	-4.47e-02	2.51e-01	3.26e-01
Chromatin modifying enzymes	215	3.24e-01	4.66e-01	0.06880	4.53e-02	-5.17e-02	2.52e-01	1.91e-01
Chromatin organization	215	3.24e-01	4.66e-01	0.06880	4.53e-02	-5.17e-02	2.52e-01	1.91e-01
Ion channel transport	141	3.87e-01	5.30e-01	0.06880	6.68e-02	-1.62e-02	1.71e-01	7.39e-01
Inflammasomes	21	8.88e-01	9.25e-01	0.06860	5.98e-02	-3.36e-02	6.35e-01	7.90e-01
Glycosaminoglycan metabolism	98	5.80e-01	6.94e-01	0.06790	-3.20e-02	5.99e-02	5.85e-01	3.06e-01
Pre-NOTCH Processing in Golgi	18	8.74e-01	9.16e-01	0.06760	6.75e-02	-3.75e-03	6.20e-01	9.78e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	5.19e-01	6.46e-01	0.06750	-3.10e-02	-5.99e-02	6.63e-01	4.00e-01
Glycerophospholipid biosynthesis	105	5.89e-01	7.01e-01	0.06740	-5.02e-02	4.49e-02	3.74e-01	4.27e-01
CRMPs in Sema3A signaling	13	8.82e-01	9.20e-01	0.06720	6.15e-02	2.73e-02	7.01e-01	8.65e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	8.34e-01	8.95e-01	0.06710	-6.69e-02	5.30e-03	5.63e-01	9.63e-01
SLC transporter disorders	77	5.04e-01	6.31e-01	0.06630	-1.92e-02	-6.35e-02	7.71e-01	3.36e-01
Signaling by NTRKs	117	3.17e-01	4.59e-01	0.06600	5.36e-02	3.86e-02	3.16e-01	4.71e-01
FLT3 Signaling	38	7.58e-01	8.38e-01	0.06580	6.58e-02	-1.02e-03	4.83e-01	9.91e-01
Signaling by Rho GTPases	608	4.09e-02	1.03e-01	0.06570	-2.79e-02	5.95e-02	2.41e-01	1.22e-02
RAF-independent MAPK1/3 activation	22	8.12e-01	8.82e-01	0.06520	3.33e-02	5.61e-02	7.87e-01	6.49e-01
Signaling by Receptor Tyrosine Kinases	449	5.01e-02	1.21e-01	0.06510	-5.43e-03	6.49e-02	8.44e-01	1.85e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	8.98e-01	9.29e-01	0.06440	-1.43e-02	6.28e-02	9.16e-01	6.45e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	8.98e-01	9.29e-01	0.06440	-1.43e-02	6.28e-02	9.16e-01	6.45e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	5.60e-01	6.79e-01	0.06410	-3.02e-02	5.65e-02	5.72e-01	2.91e-01
ESR-mediated signaling	160	4.75e-01	6.08e-01	0.06340	-3.42e-02	5.33e-02	4.55e-01	2.44e-01
Nitric oxide stimulates guanylate cyclase	15	8.86e-01	9.23e-01	0.06260	-5.92e-02	-2.03e-02	6.91e-01	8.92e-01
Regulated Necrosis	56	6.31e-01	7.41e-01	0.06250	-5.83e-02	-2.27e-02	4.51e-01	7.69e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	8.67e-01	9.16e-01	0.06250	-1.99e-02	5.93e-02	8.58e-01	5.94e-01
FOXO-mediated transcription of cell death genes	16	8.71e-01	9.16e-01	0.06230	3.14e-02	5.38e-02	8.28e-01	7.09e-01
Intra-Golgi traffic	43	8.26e-01	8.92e-01	0.06200	-3.42e-02	5.16e-02	6.98e-01	5.58e-01
G alpha (i) signalling events	194	2.10e-01	3.42e-01	0.06150	2.53e-02	5.60e-02	5.44e-01	1.78e-01
Loss of Function of SMAD2/3 in Cancer	7	9.67e-01	9.76e-01	0.06090	5.66e-02	-2.24e-02	7.95e-01	9.18e-01
Acyl chain remodelling of PG	11	9.17e-01	9.42e-01	0.06060	5.51e-02	2.53e-02	7.52e-01	8.85e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	7.02e-01	7.99e-01	0.06000	5.99e-02	3.02e-03	4.38e-01	9.69e-01
Tie2 Signaling	16	8.83e-01	9.21e-01	0.05990	5.39e-02	2.61e-02	7.09e-01	8.56e-01
MyD88-independent TLR4 cascade	108	5.58e-01	6.79e-01	0.05920	5.87e-02	-7.65e-03	2.92e-01	8.91e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	5.58e-01	6.79e-01	0.05920	5.87e-02	-7.65e-03	2.92e-01	8.91e-01
Signalling to RAS	19	9.01e-01	9.31e-01	0.05900	5.86e-02	-6.66e-03	6.58e-01	9.60e-01
Uptake and actions of bacterial toxins	28	8.99e-01	9.30e-01	0.05790	3.55e-02	-4.58e-02	7.45e-01	6.75e-01
Signaling by CSF3 (G-CSF)	29	8.05e-01	8.77e-01	0.05750	4.67e-02	3.35e-02	6.63e-01	7.55e-01
WNT mediated activation of DVL	8	9.47e-01	9.65e-01	0.05710	5.38e-02	1.92e-02	7.92e-01	9.25e-01
RHOA GTPase cycle	139	3.63e-01	5.05e-01	0.05710	3.18e-02	4.74e-02	5.18e-01	3.35e-01
Opioid Signalling	75	6.38e-01	7.46e-01	0.05700	5.66e-02	6.99e-03	3.97e-01	9.17e-01
Molecules associated with elastic fibres	26	8.30e-01	8.92e-01	0.05700	-2.81e-02	-4.96e-02	8.04e-01	6.62e-01
RAC3 GTPase cycle	88	5.22e-01	6.48e-01	0.05690	3.80e-02	4.24e-02	5.38e-01	4.92e-01
AKT phosphorylates targets in the cytosol	14	9.34e-01	9.56e-01	0.05650	-5.58e-02	8.90e-03	7.18e-01	9.54e-01
Relaxin receptors	5	9.69e-01	9.76e-01	0.05510	5.25e-02	1.68e-02	8.39e-01	9.48e-01
Platelet calcium homeostasis	22	9.07e-01	9.36e-01	0.05510	-1.16e-02	5.39e-02	9.25e-01	6.62e-01
Signaling by NOTCH1	68	7.89e-01	8.62e-01	0.05490	4.58e-02	-3.02e-02	5.13e-01	6.67e-01
Elevation of cytosolic Ca2+ levels	13	9.57e-01	9.70e-01	0.05490	-3.97e-02	3.79e-02	8.04e-01	8.13e-01
RHO GTPase cycle	412	1.19e-01	2.33e-01	0.05490	5.48e-02	2.04e-03	5.62e-02	9.43e-01
Rab regulation of trafficking	122	6.38e-01	7.46e-01	0.05450	-2.32e-02	4.93e-02	6.58e-01	3.47e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	9.58e-01	9.70e-01	0.05440	4.80e-02	-2.55e-02	7.73e-01	8.78e-01
Nicotinate metabolism	26	9.18e-01	9.43e-01	0.05390	3.35e-02	-4.22e-02	7.68e-01	7.10e-01
FGFR4 ligand binding and activation	5	9.69e-01	9.76e-01	0.05330	-2.52e-02	-4.69e-02	9.22e-01	8.56e-01
Constitutive Signaling by Overexpressed ERBB2	11	9.46e-01	9.65e-01	0.05250	5.76e-03	5.21e-02	9.74e-01	7.65e-01
Signaling by Interleukins	391	9.42e-02	1.94e-01	0.05220	4.27e-02	2.99e-02	1.47e-01	3.10e-01
Signaling by TGFB family members	139	4.43e-01	5.82e-01	0.05160	4.48e-02	2.56e-02	3.62e-01	6.03e-01
Keratan sulfate/keratin metabolism	28	8.67e-01	9.16e-01	0.05140	1.03e-02	5.04e-02	9.25e-01	6.45e-01
Peptide hormone metabolism	54	8.55e-01	9.07e-01	0.05110	3.75e-02	-3.46e-02	6.33e-01	6.60e-01
MAPK family signaling cascades	264	3.69e-01	5.10e-01	0.05110	-1.05e-02	5.00e-02	7.68e-01	1.62e-01
ERK/MAPK targets	22	9.16e-01	9.42e-01	0.05060	-6.07e-03	5.02e-02	9.61e-01	6.83e-01
Glucagon-type ligand receptors	20	9.42e-01	9.63e-01	0.05020	-2.58e-02	4.30e-02	8.41e-01	7.39e-01
Toll Like Receptor 3 (TLR3) Cascade	104	6.70e-01	7.73e-01	0.04990	4.95e-02	-6.47e-03	3.83e-01	9.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	5.69e-01	6.84e-01	0.04970	4.60e-02	1.90e-02	4.09e-01	7.34e-01
Toll Like Receptor TLR6:TLR2 Cascade	108	5.69e-01	6.84e-01	0.04970	4.60e-02	1.90e-02	4.09e-01	7.34e-01
Signaling by NOTCH2	33	8.94e-01	9.28e-01	0.04970	1.43e-02	-4.76e-02	8.87e-01	6.36e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	55	7.45e-01	8.30e-01	0.04940	-4.37e-02	-2.31e-02	5.75e-01	7.67e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	55	7.45e-01	8.30e-01	0.04940	-4.37e-02	-2.31e-02	5.75e-01	7.67e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	55	7.45e-01	8.30e-01	0.04940	-4.37e-02	-2.31e-02	5.75e-01	7.67e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	55	7.45e-01	8.30e-01	0.04940	-4.37e-02	-2.31e-02	5.75e-01	7.67e-01
Signaling by NOTCH1 in Cancer	55	7.45e-01	8.30e-01	0.04940	-4.37e-02	-2.31e-02	5.75e-01	7.67e-01
Signaling by ERBB2	44	8.89e-01	9.25e-01	0.04860	-2.95e-02	3.87e-02	7.35e-01	6.57e-01
SHC-mediated cascade:FGFR4	11	9.56e-01	9.70e-01	0.04850	4.84e-02	1.03e-03	7.81e-01	9.95e-01
Elastic fibre formation	33	9.12e-01	9.39e-01	0.04820	2.34e-02	-4.22e-02	8.16e-01	6.75e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	7.16e-01	8.11e-01	0.04820	4.70e-02	-1.09e-02	4.17e-01	8.51e-01
Metabolism of fat-soluble vitamins	28	9.15e-01	9.42e-01	0.04810	-4.59e-02	1.44e-02	6.74e-01	8.95e-01
Epigenetic regulation of gene expression	263	2.66e-01	4.08e-01	0.04780	-4.06e-02	-2.52e-02	2.57e-01	4.81e-01
MyD88 dependent cascade initiated on endosome	101	7.35e-01	8.25e-01	0.04770	4.52e-02	-1.51e-02	4.32e-01	7.93e-01
PIP3 activates AKT signaling	235	4.84e-01	6.16e-01	0.04740	-4.55e-02	1.32e-02	2.29e-01	7.27e-01
Metabolism of lipids	642	8.67e-02	1.83e-01	0.04710	-4.70e-02	-2.62e-03	4.21e-02	9.10e-01
MITF-M-dependent gene expression	83	7.68e-01	8.43e-01	0.04690	4.58e-02	-1.03e-02	4.71e-01	8.71e-01
Diseases of glycosylation	109	6.68e-01	7.72e-01	0.04670	-4.67e-02	-4.53e-05	4.00e-01	9.99e-01
RND1 GTPase cycle	37	8.70e-01	9.16e-01	0.04630	1.92e-03	4.62e-02	9.84e-01	6.27e-01
Toll Like Receptor 9 (TLR9) Cascade	108	7.55e-01	8.36e-01	0.04620	4.11e-02	-2.12e-02	4.61e-01	7.03e-01
Alpha-protein kinase 1 signaling pathway	11	9.61e-01	9.72e-01	0.04540	-4.54e-02	-2.31e-03	7.94e-01	9.89e-01
Factors involved in megakaryocyte development and platelet production	129	5.64e-01	6.81e-01	0.04530	2.02e-02	4.05e-02	6.92e-01	4.27e-01
TBC/RABGAPs	45	8.65e-01	9.15e-01	0.04510	-4.52e-03	4.49e-02	9.58e-01	6.02e-01
Synthesis of PA	31	9.06e-01	9.35e-01	0.04510	5.31e-03	-4.48e-02	9.59e-01	6.66e-01
Signaling by NTRK1 (TRKA)	102	6.64e-01	7.70e-01	0.04480	4.31e-02	1.22e-02	4.52e-01	8.32e-01
Retrograde transport at the Trans-Golgi-Network	49	8.08e-01	8.79e-01	0.04420	-3.80e-02	-2.27e-02	6.46e-01	7.83e-01
Activation of NMDA receptors and postsynaptic events	74	7.18e-01	8.13e-01	0.04420	3.09e-02	3.17e-02	6.46e-01	6.38e-01
Signaling by FGFR in disease	52	8.23e-01	8.91e-01	0.04410	-4.33e-02	-8.52e-03	5.89e-01	9.15e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	7.48e-01	8.31e-01	0.04350	4.26e-02	-8.95e-03	4.51e-01	8.74e-01
Synthesis of UDP-N-acetyl-glucosamine	8	9.70e-01	9.77e-01	0.04320	1.25e-02	4.14e-02	9.51e-01	8.39e-01
Retinoid metabolism and transport	25	9.43e-01	9.64e-01	0.04190	3.94e-02	-1.41e-02	7.33e-01	9.03e-01
Collagen formation	66	8.76e-01	9.16e-01	0.04170	3.47e-02	-2.31e-02	6.26e-01	7.45e-01
IKK complex recruitment mediated by RIP1	23	9.51e-01	9.68e-01	0.04130	-1.58e-02	3.82e-02	8.96e-01	7.51e-01
p75 NTR receptor-mediated signalling	89	7.33e-01	8.24e-01	0.04110	-3.89e-02	-1.33e-02	5.26e-01	8.28e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	9.68e-01	9.76e-01	0.04100	-3.70e-02	-1.78e-02	8.48e-01	9.26e-01
Toll Like Receptor 2 (TLR2) Cascade	109	6.96e-01	7.94e-01	0.04090	3.95e-02	1.05e-02	4.76e-01	8.49e-01
Toll Like Receptor TLR1:TLR2 Cascade	109	6.96e-01	7.94e-01	0.04090	3.95e-02	1.05e-02	4.76e-01	8.49e-01
TAK1-dependent IKK and NF-kappa-B activation	43	9.26e-01	9.50e-01	0.04000	2.52e-02	-3.10e-02	7.75e-01	7.25e-01
Signal Transduction	2058	1.77e-03	7.74e-03	0.03850	2.54e-02	2.89e-02	5.75e-02	3.05e-02
SUMOylation of transcription cofactors	44	9.10e-01	9.38e-01	0.03850	-3.76e-02	8.27e-03	6.66e-01	9.24e-01
Oncogene Induced Senescence	33	8.96e-01	9.29e-01	0.03810	2.68e-02	2.71e-02	7.90e-01	7.88e-01
Formation of the nephric duct	8	9.81e-01	9.86e-01	0.03740	1.93e-04	3.74e-02	9.99e-01	8.55e-01
Post NMDA receptor activation events	64	8.29e-01	8.92e-01	0.03700	1.51e-02	3.38e-02	8.35e-01	6.40e-01
ERBB2 Regulates Cell Motility	10	9.81e-01	9.86e-01	0.03660	3.53e-02	-9.70e-03	8.47e-01	9.58e-01
p38MAPK events	13	9.67e-01	9.76e-01	0.03370	1.89e-02	2.80e-02	9.06e-01	8.61e-01
EPH-ephrin mediated repulsion of cells	43	8.95e-01	9.28e-01	0.03370	-2.13e-02	-2.60e-02	8.09e-01	7.68e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	9.55e-01	9.70e-01	0.03170	2.38e-02	2.09e-02	8.54e-01	8.72e-01
Trafficking of AMPA receptors	20	9.55e-01	9.70e-01	0.03170	2.38e-02	2.09e-02	8.54e-01	8.72e-01
Phospholipase C-mediated cascade; FGFR3	5	9.90e-01	9.93e-01	0.03130	3.01e-02	8.53e-03	9.07e-01	9.74e-01
Cargo concentration in the ER	31	9.48e-01	9.65e-01	0.02990	5.96e-03	2.93e-02	9.54e-01	7.77e-01
Inactivation of CSF3 (G-CSF) signaling	24	9.54e-01	9.70e-01	0.02950	-1.55e-02	-2.51e-02	8.96e-01	8.31e-01
MyD88 cascade initiated on plasma membrane	95	8.48e-01	9.04e-01	0.02790	1.45e-02	2.39e-02	8.07e-01	6.88e-01
Toll Like Receptor 10 (TLR10) Cascade	95	8.48e-01	9.04e-01	0.02790	1.45e-02	2.39e-02	8.07e-01	6.88e-01
Toll Like Receptor 5 (TLR5) Cascade	95	8.48e-01	9.04e-01	0.02790	1.45e-02	2.39e-02	8.07e-01	6.88e-01
VEGFR2 mediated vascular permeability	26	9.58e-01	9.70e-01	0.02780	-2.57e-02	-1.07e-02	8.21e-01	9.25e-01
Signaling by Nuclear Receptors	214	6.96e-01	7.94e-01	0.02780	-2.39e-02	-1.42e-02	5.47e-01	7.21e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	9.30e-01	9.53e-01	0.02710	-2.55e-02	-9.05e-03	7.60e-01	9.14e-01
The canonical retinoid cycle in rods (twilight vision)	9	9.86e-01	9.90e-01	0.02710	-2.45e-02	-1.14e-02	8.99e-01	9.53e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	9.89e-01	9.93e-01	0.02620	1.33e-02	2.25e-02	9.52e-01	9.18e-01
SLC-mediated transmembrane transport	175	8.70e-01	9.16e-01	0.02550	-1.13e-02	2.29e-02	7.97e-01	6.01e-01
MITF-M-regulated melanocyte development	113	8.80e-01	9.20e-01	0.02410	5.03e-03	2.36e-02	9.26e-01	6.65e-01
Cytokine Signaling in Immune system	670	4.38e-01	5.79e-01	0.02360	-1.44e-02	-1.87e-02	5.25e-01	4.09e-01
G-protein beta:gamma signalling	29	9.67e-01	9.76e-01	0.02240	1.37e-02	1.77e-02	8.98e-01	8.69e-01
Collagen biosynthesis and modifying enzymes	48	9.72e-01	9.78e-01	0.02200	1.96e-02	-9.94e-03	8.14e-01	9.05e-01
Phase I - Functionalization of compounds	70	9.60e-01	9.71e-01	0.02180	-9.46e-03	1.97e-02	8.91e-01	7.76e-01
Metabolism of steroids	125	9.45e-01	9.65e-01	0.01860	-6.49e-03	1.75e-02	9.00e-01	7.36e-01
Cell death signalling via NRAGE, NRIF and NADE	69	9.56e-01	9.70e-01	0.01850	-1.83e-02	-3.30e-03	7.93e-01	9.62e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	9.97e-01	9.99e-01	0.01800	-1.34e-02	1.21e-02	9.48e-01	9.53e-01
Diseases of signal transduction by growth factor receptors and second messengers	404	8.28e-01	8.92e-01	0.01740	-1.95e-03	1.73e-02	9.46e-01	5.51e-01
Intracellular signaling by second messengers	268	8.71e-01	9.16e-01	0.01660	-1.64e-02	-2.51e-03	6.43e-01	9.44e-01
Signaling by ERBB4	45	9.86e-01	9.90e-01	0.01650	-8.52e-03	1.41e-02	9.21e-01	8.70e-01
FGFR2 ligand binding and activation	9	9.98e-01	9.99e-01	0.01500	1.31e-02	-7.37e-03	9.46e-01	9.69e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	9.98e-01	9.99e-01	0.01190	3.58e-03	1.14e-02	9.88e-01	9.62e-01
TGFBR1 KD Mutants in Cancer	6	9.98e-01	9.99e-01	0.01190	3.58e-03	1.14e-02	9.88e-01	9.62e-01
Induction of Cell-Cell Fusion	8	9.99e-01	9.99e-01	0.00783	7.72e-03	-1.32e-03	9.70e-01	9.95e-01
Estrogen-dependent gene expression	97	9.99e-01	9.99e-01	0.00295	-2.27e-04	2.94e-03	9.97e-01	9.60e-01

---

Detailed Gene set reports

FASTK family proteins regulate processing and stability of mitochondrial RNAs

FASTK family proteins regulate processing and stability of mitochondrial RNAs

metric	value
setSize	19
pMANOVA	6.31e-10
p.adjustMANOVA	8.64e-09
s.dist	1
s.crp_eos_adj	-0.727
s.dex_eos_adj	0.687
p.crp_eos_adj	4.07e-08
p.dex_eos_adj	2.15e-07

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MT-ND2	-10255	9404
MT-ND1	-10176	9474
MT-ND3	-10179	8131
MT-CO2	-9587	8379
MT-ATP6	-8914	8600
MT-CYB	-7734	9007
MT-CO3	-9085	7529
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
TBRG4	-7523	8462
MT-ND5	-6747	9069
MT-CO1	-7201	7481
FASTKD5	-2928	8254
MT-ATP8	-5197	2308

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
FASTK	-3800	-1948
FASTKD2	-6873	-7524
FASTKD5	-2928	8254
MT-ATP6	-8914	8600
MT-ATP8	-5197	2308
MT-CO1	-7201	7481
MT-CO2	-9587	8379
MT-CO3	-9085	7529
MT-CYB	-7734	9007
MT-ND1	-10176	9474
MT-ND2	-10255	9404
MT-ND3	-10179	8131
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
MT-ND5	-6747	9069
MT-ND6	633	7486
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
TBRG4	-7523	8462

---

---

Formation of the ureteric bud

Formation of the ureteric bud

metric	value
setSize	5
pMANOVA	0.0043
p.adjustMANOVA	0.0168
s.dist	0.959
s.crp_eos_adj	-0.492
s.dex_eos_adj	0.824
p.crp_eos_adj	0.0569
p.dex_eos_adj	0.00142

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
WNT11	-9087	9487
FOXC1	-7607	10223
RET	-7477	7926
ITGB1	-6368	6173

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
FOXC1	-7607	10223
GREM1	5934	7769
ITGB1	-6368	6173
RET	-7477	7926
WNT11	-9087	9487

---

---

Modulation by Mtb of host immune system

Modulation by Mtb of host immune system

metric	value
setSize	7
pMANOVA	0.000497
p.adjustMANOVA	0.00248
s.dist	0.955
s.crp_eos_adj	-0.826
s.dex_eos_adj	0.478
p.crp_eos_adj	0.000153
p.dex_eos_adj	0.0284

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
UBC	-9922	8371
TLR2	-7510	10167
MRC1	-8238	7355
B2M	-10300	5647
UBA52	-9493	3637
UBB	-5642	147

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
B2M	-10300	5647
MRC1	-8238	7355
RPS27A	-9093	-3694
TLR2	-7510	10167
UBA52	-9493	3637
UBB	-5642	147
UBC	-9922	8371

---

---

Mitochondrial RNA degradation

Mitochondrial RNA degradation

metric	value
setSize	25
pMANOVA	8.44e-11
p.adjustMANOVA	1.35e-09
s.dist	0.911
s.crp_eos_adj	-0.684
s.dex_eos_adj	0.602
p.crp_eos_adj	3.17e-09
p.dex_eos_adj	1.91e-07

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MT-ND2	-10255	9404
MT-ND1	-10176	9474
MT-ND3	-10179	8131
MT-CO2	-9587	8379
MT-ATP6	-8914	8600
MT-CYB	-7734	9007
MT-CO3	-9085	7529
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
TBRG4	-7523	8462
MT-ND5	-6747	9069
MT-CO1	-7201	7481
GRSF1	-9526	5527
SLIRP	-9948	5292
SUPV3L1	-4503	9775
PNPT1	-6800	5002
FASTKD5	-2928	8254
MT-ATP8	-5197	2308

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
FASTK	-3800	-1948
FASTKD2	-6873	-7524
FASTKD5	-2928	8254
GRSF1	-9526	5527
LRPPRC	-6121	1009
MT-ATP6	-8914	8600
MT-ATP8	-5197	2308
MT-CO1	-7201	7481
MT-CO2	-9587	8379
MT-CO3	-9085	7529
MT-CYB	-7734	9007
MT-ND1	-10176	9474
MT-ND2	-10255	9404
MT-ND3	-10179	8131
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
MT-ND5	-6747	9069
MT-ND6	633	7486
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
PNPT1	-6800	5002
REXO2	3731	-9271
SLIRP	-9948	5292
SUPV3L1	-4503	9775
TBRG4	-7523	8462

---

---

Defective binding of VWF variant to GPIb:IX:V

Defective binding of VWF variant to GPIb:IX:V

metric	value
setSize	7
pMANOVA	0.00146
p.adjustMANOVA	0.00657
s.dist	0.906
s.crp_eos_adj	-0.544
s.dex_eos_adj	0.724
p.crp_eos_adj	0.0127
p.dex_eos_adj	0.000904

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
GP9	-10054	9506
GP1BB	-9935	8844
VWF	-9127	8432
GP1BA	-7008	7170
COL1A1	-2357	8986
GP5	-553	1988

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
COL1A1	-2357	8986
COL1A2	574	5629
GP1BA	-7008	7170
GP1BB	-9935	8844
GP5	-553	1988
GP9	-10054	9506
VWF	-9127	8432

---

---

Enhanced binding of GP1BA variant to VWF multimer:collagen

Enhanced binding of GP1BA variant to VWF multimer:collagen

metric	value
setSize	7
pMANOVA	0.00146
p.adjustMANOVA	0.00657
s.dist	0.906
s.crp_eos_adj	-0.544
s.dex_eos_adj	0.724
p.crp_eos_adj	0.0127
p.dex_eos_adj	0.000904

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
GP9	-10054	9506
GP1BB	-9935	8844
VWF	-9127	8432
GP1BA	-7008	7170
COL1A1	-2357	8986
GP5	-553	1988

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
COL1A1	-2357	8986
COL1A2	574	5629
GP1BA	-7008	7170
GP1BB	-9935	8844
GP5	-553	1988
GP9	-10054	9506
VWF	-9127	8432

---

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

metric	value
setSize	20
pMANOVA	3.29e-10
p.adjustMANOVA	4.82e-09
s.dist	0.898
s.crp_eos_adj	-0.853
s.dex_eos_adj	0.282
p.crp_eos_adj	3.91e-11
p.dex_eos_adj	0.029

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MT-ATP6	-8914	8600
ATP5MK	-10380	6930
ATP5F1B	-9413	6189
ATP5F1E	-10002	4842
ATP5MC3	-8106	5373
DMAC2L	-8048	4018
ATP5F1C	-10017	3023
ATP5PB	-9735	2952
ATP5PF	-9668	2870
ATP5ME	-5434	4823
ATP5MG	-10105	1320
MT-ATP8	-5197	2308
ATP5F1A	-9449	970
ATP5MJ	-8413	957
ATP5MC2	-9311	87
ATP5PO	-9871	76
ATP5MC1	-9957	62

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ATP5F1A	-9449	970
ATP5F1B	-9413	6189
ATP5F1C	-10017	3023
ATP5F1D	-7280	-3854
ATP5F1E	-10002	4842
ATP5MC1	-9957	62
ATP5MC2	-9311	87
ATP5MC3	-8106	5373
ATP5ME	-5434	4823
ATP5MF	-8779	-1709
ATP5MG	-10105	1320
ATP5MJ	-8413	957
ATP5MK	-10380	6930
ATP5PB	-9735	2952
ATP5PD	-9684	-2705
ATP5PF	-9668	2870
ATP5PO	-9871	76
DMAC2L	-8048	4018
MT-ATP6	-8914	8600
MT-ATP8	-5197	2308

---

---

Protein repair

Protein repair

metric	value
setSize	6
pMANOVA	0.00441
p.adjustMANOVA	0.0172
s.dist	0.88
s.crp_eos_adj	-0.477
s.dex_eos_adj	0.74
p.crp_eos_adj	0.043
p.dex_eos_adj	0.0017

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MSRB3	-9740	8941
MSRB2	-8294	8276
TXN	-7034	8504
PCMT1	-4195	7077
MSRA	-2138	5315

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
MSRA	-2138	5315
MSRB1	2839	6253
MSRB2	-8294	8276
MSRB3	-9740	8941
PCMT1	-4195	7077
TXN	-7034	8504

---

---

MECP2 regulates transcription of neuronal ligands

MECP2 regulates transcription of neuronal ligands

metric	value
setSize	5
pMANOVA	0.0121
p.adjustMANOVA	0.0394
s.dist	0.869
s.crp_eos_adj	0.468
s.dex_eos_adj	-0.733
p.crp_eos_adj	0.0702
p.dex_eos_adj	0.00453

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MECP2	9510	-9602
SIN3A	10424	-8347
HDAC1	2427	-11446
DLL1	2832	-7885
CREB1	2945	-6732

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
CREB1	2945	-6732
DLL1	2832	-7885
HDAC1	2427	-11446
MECP2	9510	-9602
SIN3A	10424	-8347

---

---

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

metric	value
setSize	24
pMANOVA	3.66e-09
p.adjustMANOVA	4.36e-08
s.dist	0.851
s.crp_eos_adj	-0.636
s.dex_eos_adj	0.566
p.crp_eos_adj	6.94e-08
p.dex_eos_adj	1.57e-06

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MT-ND2	-10255	9404
MT-ND1	-10176	9474
MT-ND3	-10179	8131
MT-CO2	-9587	8379
MT-ATP6	-8914	8600
MT-CYB	-7734	9007
MT-CO3	-9085	7529
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
MT-ND5	-6747	9069
MT-CO1	-7201	7481
PRORP	-6415	8022
MT-TC	-4293	4735
ELAC2	-6479	2659
MT-TA	-2527	5636
MT-ATP8	-5197	2308
TRMT10C	-7181	565
MT-TP	-2203	1787

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ELAC2	-6479	2659
HSD17B10	-7812	-2666
MT-ATP6	-8914	8600
MT-ATP8	-5197	2308
MT-CO1	-7201	7481
MT-CO2	-9587	8379
MT-CO3	-9085	7529
MT-CYB	-7734	9007
MT-ND1	-10176	9474
MT-ND2	-10255	9404
MT-ND3	-10179	8131
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
MT-ND5	-6747	9069
MT-ND6	633	7486
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
MT-TA	-2527	5636
MT-TC	-4293	4735
MT-TN	1263	-2871
MT-TP	-2203	1787
PRORP	-6415	8022
TRMT10C	-7181	565
TRNT1	1121	-8504

---

---

RNA Polymerase I Promoter Opening

RNA Polymerase I Promoter Opening

metric	value
setSize	17
pMANOVA	1.03e-06
p.adjustMANOVA	8.36e-06
s.dist	0.844
s.crp_eos_adj	-0.676
s.dex_eos_adj	0.506
p.crp_eos_adj	1.39e-06
p.dex_eos_adj	0.000301

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
H2AC6	-10475	9891
H2BC21	-10433	9790
H2BC11	-10260	9781
H2BC12	-10075	9601
H2BC4	-9770	9809
H2BC9	-9292	9901
H2BC5	-9559	9491
H2BC17	-9549	9385
H2BC15	-8044	9295
H3-3A	-7627	7362
MBD2	-6465	8407
H2AJ	-9644	3819
MAPK3	-2454	1078

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
H2AC20	-9251.0	-2501.0
H2AC6	-10475.0	9891.0
H2AJ	-9644.0	3819.0
H2AZ2	-7006.0	-9940.0
H2BC11	-10260.0	9781.0
H2BC12	-10075.0	9601.0
H2BC15	-8044.0	9295.0
H2BC17	-9549.0	9385.0
H2BC21	-10433.0	9790.0
H2BC4	-9770.0	9809.0
H2BC5	-9559.0	9491.0
H2BC9	-9292.0	9901.0
H3-3A	-7627.0	7362.0
H3C15	5170.5	-2477.5
MAPK3	-2454.0	1078.0
MBD2	-6465.0	8407.0
UBTF	6711.0	-10702.0

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	88
pMANOVA	1.41e-47
p.adjustMANOVA	1.6e-45
s.dist	0.843
s.crp_eos_adj	-0.843
s.dex_eos_adj	-0.014
p.crp_eos_adj	1.15e-42
p.dex_eos_adj	0.82

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL13	-7350	-6766
RPL12	-9895	-4596
RPL27A	-9269	-4885
RPL22	-9607	-4134
RPL39L	-8440	-4668
RPL7	-10191	-3859
RPS17	-8643	-4422
RPS12	-8239	-4234
RPL31	-9467	-3680
RPS3A	-10096	-3399
RPS27A	-9093	-3694
RPLP1	-7065	-4669
RPL35	-9316	-3278
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS20	-10025	-2100
RPL36	-7435	-2774
RPL5	-10094	-2038
RPS13	-10206	-1877
RPL13A	-9486	-1976

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EEF1A1	-9700	-1708
EEF2	-7220	583
FAU	-8965	528
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	100
pMANOVA	1.17e-52
p.adjustMANOVA	1.88e-50
s.dist	0.843
s.crp_eos_adj	-0.842
s.dex_eos_adj	0.0159
p.crp_eos_adj	3.11e-48
p.dex_eos_adj	0.783

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
EIF3J	-8886	6067
EIF3B	-8354	5747
RPL26L1	-8789	4937
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
UBA52	-9493	3637
EIF1AX	-6420	5279
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF3H	-9904	2487
RPL8	-9829	1920
RPS14	-8103	2274
RPL15	-9886	1682
RPS27L	-8746	1792
EIF3A	-6825	2199
EIF3G	-8962	1578
RPL39	-9435	1424

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
FAU	-8965	528
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	93
pMANOVA	1.9e-49
p.adjustMANOVA	2.45e-47
s.dist	0.835
s.crp_eos_adj	-0.834
s.dex_eos_adj	-0.0176
p.crp_eos_adj	3.7e-44
p.dex_eos_adj	0.769

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL13	-7350	-6766
RPL12	-9895	-4596
RPL27A	-9269	-4885
EEF1B2	-9600	-4324
RPL22	-9607	-4134
RPL39L	-8440	-4668
RPL7	-10191	-3859
RPS17	-8643	-4422
RPS12	-8239	-4234
RPL31	-9467	-3680
RPS3A	-10096	-3399
RPS27A	-9093	-3694
RPLP1	-7065	-4669
RPL35	-9316	-3278
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS20	-10025	-2100
RPL36	-7435	-2774
RPL5	-10094	-2038
EEF1A1P5	-8839	-2290

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EEF1A1	-9700	-1708
EEF1A1P5	-8839	-2290
EEF1A2	-106	353
EEF1B2	-9600	-4324
EEF1D	-7498	-341
EEF1G	-9229	-1566
EEF2	-7220	583
FAU	-8965	528
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

Tandem pore domain potassium channels

Tandem pore domain potassium channels

metric	value
setSize	5
pMANOVA	0.0183
p.adjustMANOVA	0.0546
s.dist	0.831
s.crp_eos_adj	0.463
s.dex_eos_adj	-0.69
p.crp_eos_adj	0.0729
p.dex_eos_adj	0.0075

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
KCNK13	11020	-6621
KCNK10	6034	-11174
KCNK7	10561	-4232
KCNK17	1684	-8317

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
KCNK10	6034	-11174
KCNK13	11020	-6621
KCNK17	1684	-8317
KCNK6	-1404	-11332
KCNK7	10561	-4232

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	88
pMANOVA	9.47e-46
p.adjustMANOVA	9.63e-44
s.dist	0.831
s.crp_eos_adj	-0.831
s.dex_eos_adj	0.000498
p.crp_eos_adj	1.49e-41
p.dex_eos_adj	0.994

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
GRSF1	-9526	5527
RPL26L1	-8789	4937
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
UBA52	-9493	3637
RPS4Y1	-7140	3934
RPL8	-9829	1920
RPS14	-8103	2274
RPL15	-9886	1682
RPS27L	-8746	1792
RPL39	-9435	1424
RPL7A	-9896	1278
RPL29	-10019	914
RPS11	-9343	895
RPLP0	-9307	804
RPL37	-8134	800
RPL24	-10169	629
RPS27	-9690	576

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
DNAJC3	3670	7321
FAU	-8965	528
GRSF1	-9526	5527
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	110
pMANOVA	4.15e-54
p.adjustMANOVA	8.03e-52
s.dist	0.828
s.crp_eos_adj	-0.826
s.dex_eos_adj	0.054
p.crp_eos_adj	6.07e-51
p.dex_eos_adj	0.328

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
RPL26L1	-8789	4937
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
EIF4H	-8741	3960
UBA52	-9493	3637
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2S1	-4353	5718
EIF3H	-9904	2487
RPL8	-9829	1920
RPS14	-8103	2274

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4G1	781	8831
EIF4H	-8741	3960
FAU	-8965	528
PABPC1	-9588	1364
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

SUMO is conjugated to E1 (UBA2:SAE1)

SUMO is conjugated to E1 (UBA2:SAE1)

metric	value
setSize	5
pMANOVA	0.0146
p.adjustMANOVA	0.0458
s.dist	0.824
s.crp_eos_adj	-0.743
s.dex_eos_adj	0.356
p.crp_eos_adj	0.00399
p.dex_eos_adj	0.168

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
SAE1	-10055	6672
UBA2	-7336	7043
SUMO3	-7807	3288
SUMO2	-8086	539

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
SAE1	-10055	6672
SUMO1	-5167	-1663
SUMO2	-8086	539
SUMO3	-7807	3288
UBA2	-7336	7043

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	111
pMANOVA	4.91e-54
p.adjustMANOVA	8.63e-52
s.dist	0.824
s.crp_eos_adj	-0.822
s.dex_eos_adj	0.0532
p.crp_eos_adj	7.36e-51
p.dex_eos_adj	0.333

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
RPL26L1	-8789	4937
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
EIF4H	-8741	3960
UBA52	-9493	3637
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2S1	-4353	5718
EIF3H	-9904	2487
RPL8	-9829	1920
EIF5	-8531	2193

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4G1	781	8831
EIF4H	-8741	3960
EIF5	-8531	2193
EIF5B	-4212	-1907
FAU	-8965	528
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

Formation of xylulose-5-phosphate

Formation of xylulose-5-phosphate

metric	value
setSize	5
pMANOVA	0.000422
p.adjustMANOVA	0.00215
s.dist	0.823
s.crp_eos_adj	-0.602
s.dex_eos_adj	-0.56
p.crp_eos_adj	0.0197
p.dex_eos_adj	0.03

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
XYLB	-9300	-7021
CRYL1	-8771	-6765
AKR1A1	-9195	-6168
DCXR	-9658	-3144

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AKR1A1	-9195	-6168
CRYL1	-8771	-6765
DCXR	-9658	-3144
SORD	6231	-11425
XYLB	-9300	-7021

---

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

metric	value
setSize	36
pMANOVA	1.55e-18
p.adjustMANOVA	5.53e-17
s.dist	0.819
s.crp_eos_adj	-0.819
s.dex_eos_adj	0.00516
p.crp_eos_adj	1.72e-17
p.dex_eos_adj	0.957

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPSA	-9568	4040
RPS4X	-10092	3529
HNRNPA1	-9026	3889
RPS4Y1	-7140	3934
RPS14	-8103	2274
RPS27L	-8746	1792
RPS11	-9343	895
RPS27	-9690	576
FAU	-8965	528
RPS15A	-9864	438
RPS9	-9546	341
RPS29	-7205	240
RPS3	-9514	39

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EEF1A1	-9700	-1708
FAU	-8965	528
HNRNPA1	-9026	3889
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040

---

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

metric	value
setSize	118
pMANOVA	5.82e-57
p.adjustMANOVA	1.25e-54
s.dist	0.818
s.crp_eos_adj	-0.817
s.dex_eos_adj	0.0453
p.crp_eos_adj	2.87e-53
p.dex_eos_adj	0.395

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
RPL26L1	-8789	4937
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
EIF4H	-8741	3960
UBA52	-9493	3637
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2B2	-9053	2797
EIF2S1	-4353	5718
EIF3H	-9904	2487
EIF2B4	-5452	3788

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2B1	-8805	-8266
EIF2B2	-9053	2797
EIF2B3	-6024	-7686
EIF2B4	-5452	3788
EIF2B5	-3131	-4487
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4EBP1	-10212	1213
EIF4G1	781	8831
EIF4H	-8741	3960
EIF5	-8531	2193
EIF5B	-4212	-1907
FAU	-8965	528
PABPC1	-9588	1364
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

metric	value
setSize	118
pMANOVA	5.82e-57
p.adjustMANOVA	1.25e-54
s.dist	0.818
s.crp_eos_adj	-0.817
s.dex_eos_adj	0.0453
p.crp_eos_adj	2.87e-53
p.dex_eos_adj	0.395

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
RPL26L1	-8789	4937
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
EIF4H	-8741	3960
UBA52	-9493	3637
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2B2	-9053	2797
EIF2S1	-4353	5718
EIF3H	-9904	2487
EIF2B4	-5452	3788

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2B1	-8805	-8266
EIF2B2	-9053	2797
EIF2B3	-6024	-7686
EIF2B4	-5452	3788
EIF2B5	-3131	-4487
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4EBP1	-10212	1213
EIF4G1	781	8831
EIF4H	-8741	3960
EIF5	-8531	2193
EIF5B	-4212	-1907
FAU	-8965	528
PABPC1	-9588	1364
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637

---

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

metric	value
setSize	51
pMANOVA	2.55e-24
p.adjustMANOVA	1.07e-22
s.dist	0.816
s.crp_eos_adj	-0.813
s.dex_eos_adj	0.0727
p.crp_eos_adj	9.14e-24
p.dex_eos_adj	0.369

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
EIF3J	-8886	6067
EIF3B	-8354	5747
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
EIF1AX	-6420	5279
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF2S1	-4353	5718
EIF3H	-9904	2487
RPS14	-8103	2274
EIF2S3	-8788	1976
RPS27L	-8746	1792
EIF3A	-6825	2199
EIF3G	-8962	1578
EIF3K	-9764	886
EIF2S2	-8035	1063
RPS11	-9343	895
RPS27	-9690	576
EIF3E	-9856	483

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
FAU	-8965	528
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040

---

---

Interleukin-21 signaling

Interleukin-21 signaling

metric	value
setSize	9
pMANOVA	0.00124
p.adjustMANOVA	0.00567
s.dist	0.814
s.crp_eos_adj	0.628
s.dex_eos_adj	-0.517
p.crp_eos_adj	0.00111
p.dex_eos_adj	0.00718

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
IL21R	11142	-11518
IL2RG	8650	-10511
STAT4	10641	-8530
STAT5B	7815	-10176
JAK3	9573	-5125
STAT1	2461	-9595

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
IL21R	11142	-11518
IL2RG	8650	-10511
JAK1	9473	982
JAK3	9573	-5125
STAT1	2461	-9595
STAT3	7681	5827
STAT4	10641	-8530
STAT5A	-943	-9235
STAT5B	7815	-10176

---

---

Mitochondrial translation initiation

Mitochondrial translation initiation

metric	value
setSize	90
pMANOVA	2.71e-41
p.adjustMANOVA	2.02e-39
s.dist	0.812
s.crp_eos_adj	-0.807
s.dex_eos_adj	0.0909
p.crp_eos_adj	4.03e-40
p.dex_eos_adj	0.136

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MRPL3	-10394	10140
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MRPL15	-10456	8814
MRPS17	-9267	6882
MRPS2	-8400	6472
MRPL36	-9299	5552
MRPL40	-9939	5084
MRPS30	-7284	6602
MRPS22	-10101	4669
MRPL32	-9897	4557
MRPL48	-9657	4635
MRPL24	-9310	4707
MRPS21	-10337	4159
MRPS27	-9511	4499
MRPS35	-9047	4638
MRPS16	-10323	3980
MRPS5	-9020	4506
MRPS15	-10133	3806
MRPL4	-8532	4487

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AURKAIP1	-7164	501
CHCHD1	-9555	-1062
DAP3	-10030	-741
ERAL1	-7967	-1507
GADD45GIP1	-9421	3582
MRPL1	-6880	3433
MRPL10	-7219	1667
MRPL11	-9724	1300
MRPL12	-9705	-1578
MRPL13	-7769	-3257
MRPL14	-8517	-1654
MRPL15	-10456	8814
MRPL16	-9445	-561
MRPL17	-9915	766
MRPL18	-8752	-4188
MRPL19	-6743	1949
MRPL2	-5522	-10048
MRPL20	-9598	2373
MRPL21	-8109	4026
MRPL22	-7418	-568
MRPL23	-8376	-504
MRPL24	-9310	4707
MRPL27	-8987	-4004
MRPL28	-6206	-854
MRPL3	-10394	10140
MRPL30	-6130	-7501
MRPL32	-9897	4557
MRPL33	-7354	-5238
MRPL34	-9812	1838
MRPL35	-5552	-4517
MRPL36	-9299	5552
MRPL37	-10432	266
MRPL38	-7021	-94
MRPL39	-5938	-1075
MRPL4	-8532	4487
MRPL40	-9939	5084
MRPL41	-5086	-4089
MRPL42	-3938	-148
MRPL43	-7618	-4753
MRPL44	-9484	2065
MRPL45	-9715	-4705
MRPL46	-9617	-2776
MRPL47	-8493	2911
MRPL48	-9657	4635
MRPL49	-8603	2878
MRPL50	-1530	715
MRPL51	-10128	494
MRPL52	-9360	-1652
MRPL53	-9120	328
MRPL54	-9275	-6380
MRPL55	-8075	2046
MRPL57	-9894	-1393
MRPL58	-9021	306
MRPL9	-8852	14
MRPS10	-6117	596
MRPS11	-9136	-1480
MRPS14	-8020	-1134
MRPS15	-10133	3806
MRPS16	-10323	3980
MRPS17	-9267	6882
MRPS18A	-8450	1116
MRPS18B	-9491	1569
MRPS18C	-9473	-5773
MRPS2	-8400	6472
MRPS21	-10337	4159
MRPS22	-10101	4669
MRPS23	-8642	-2834
MRPS24	-8476	-2182
MRPS25	-6380	-8304
MRPS26	-8776	1907
MRPS27	-9511	4499
MRPS28	-10277	-653
MRPS30	-7284	6602
MRPS31	-5590	-1630
MRPS33	-7001	-8376
MRPS34	-7831	-372
MRPS35	-9047	4638
MRPS36	-6782	356
MRPS5	-9020	4506
MRPS6	3567	-11687
MRPS7	-10040	1776
MRPS9	-7312	-10532
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
MTFMT	-8157	146
MTIF2	-9775	366
MTIF3	-8994	-2549
OXA1L	-8898	-1994
PTCD3	-8573	3086
RPS12	-8239	-4234

---

---

G2/M DNA replication checkpoint

G2/M DNA replication checkpoint

metric	value
setSize	5
pMANOVA	0.0254
p.adjustMANOVA	0.0721
s.dist	0.812
s.crp_eos_adj	-0.551
s.dex_eos_adj	0.596
p.crp_eos_adj	0.0328
p.dex_eos_adj	0.021

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
CCNB2	-9012	5562
PKMYT1	-6896	5895
CCNB1	-7719	4998
CDK1	-6732	2712

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
CCNB1	-7719	4998
CCNB2	-9012	5562
CDK1	-6732	2712
PKMYT1	-6896	5895
WEE1	2474	9887

---

---

rRNA processing in the mitochondrion

rRNA processing in the mitochondrion

metric	value
setSize	24
pMANOVA	1.03e-08
p.adjustMANOVA	1.17e-07
s.dist	0.811
s.crp_eos_adj	-0.68
s.dex_eos_adj	0.442
p.crp_eos_adj	7.81e-09
p.dex_eos_adj	0.00018

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MT-ND2	-10255	9404
MT-ND1	-10176	9474
MT-ND3	-10179	8131
MT-CO2	-9587	8379
MT-ATP6	-8914	8600
MT-CYB	-7734	9007
MT-CO3	-9085	7529
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
MT-ND5	-6747	9069
MT-CO1	-7201	7481
PRORP	-6415	8022
ELAC2	-6479	2659
NSUN4	-3182	4367
MT-ATP8	-5197	2308
MRM3	-8488	883
TRMT10C	-7181	565

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ELAC2	-6479	2659
HSD17B10	-7812	-2666
MRM1	-6593	-4367
MRM2	-10099	-4732
MRM3	-8488	883
MT-ATP6	-8914	8600
MT-ATP8	-5197	2308
MT-CO1	-7201	7481
MT-CO2	-9587	8379
MT-CO3	-9085	7529
MT-CYB	-7734	9007
MT-ND1	-10176	9474
MT-ND2	-10255	9404
MT-ND3	-10179	8131
MT-ND4	-7515	8813
MT-ND4L	-8462	7596
MT-ND5	-6747	9069
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
MTERF4	8547	-11451
NSUN4	-3182	4367
PRORP	-6415	8022
TFB1M	2011	-9238
TRMT10C	-7181	565

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	111
pMANOVA	1.2e-50
p.adjustMANOVA	1.66e-48
s.dist	0.81
s.crp_eos_adj	-0.805
s.dex_eos_adj	0.0881
p.crp_eos_adj	6.91e-49
p.dex_eos_adj	0.109

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPN1	-9289	8352
SRP72	-9097	7668
SSR3	-9815	6929
SEC61A1	-8133	8087
RPL22L1	-10142	5971
SEC11C	-9092	6520
SEC61G	-8480	6895
SPCS1	-9986	5837
RPN2	-9209	6239
SEC61B	-8033	6573
SPCS2	-7056	6779
SSR2	-9870	4430
SRPRB	-9773	4440
RPL26L1	-8789	4937
TRAM1	-7258	5587
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
UBA52	-9493	3637
SSR4	-9403	3498

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
DDOST	-9051	3588
FAU	-8965	528
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPN1	-9289	8352
RPN2	-9209	6239
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
SEC11A	-10174	-5885
SEC11C	-9092	6520
SEC61A1	-8133	8087
SEC61A2	4644	1033
SEC61B	-8033	6573
SEC61G	-8480	6895
SPCS1	-9986	5837
SPCS2	-7056	6779
SPCS3	-3044	6290
SRP14	-9355	-493
SRP19	-4245	4146
SRP54	-997	2914
SRP68	-7246	-273
SRP72	-9097	7668
SRP9	-8846	3066
SRPRA	2034	658
SRPRB	-9773	4440
SSR1	-1072	-570
SSR2	-9870	4430
SSR3	-9815	6929
SSR4	-9403	3498
TRAM1	-7258	5587
UBA52	-9493	3637

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	92
pMANOVA	5.57e-46
p.adjustMANOVA	5.98e-44
s.dist	0.81
s.crp_eos_adj	-0.81
s.dex_eos_adj	-0.0138
p.crp_eos_adj	2.94e-41
p.dex_eos_adj	0.819

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL13	-7350	-6766
RPL12	-9895	-4596
RPL27A	-9269	-4885
RPL22	-9607	-4134
RPL39L	-8440	-4668
RPL7	-10191	-3859
RPS17	-8643	-4422
RPS12	-8239	-4234
RPL31	-9467	-3680
RPS3A	-10096	-3399
RPS27A	-9093	-3694
RPLP1	-7065	-4669
RPL35	-9316	-3278
TRMT112	-9206	-3259
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS20	-10025	-2100
RPL36	-7435	-2774
RPL5	-10094	-2038
RPS13	-10206	-1877

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
APEH	-8186	931
ETF1	-2338	4540
FAU	-8965	528
GSPT1	-2718	8704
GSPT2	-1663	-6497
N6AMT1	5290	-8948
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
TRMT112	-9206	-3259
UBA52	-9493	3637

---

---

Post-transcriptional silencing by small RNAs

Post-transcriptional silencing by small RNAs

metric	value
setSize	7
pMANOVA	0.00389
p.adjustMANOVA	0.0156
s.dist	0.81
s.crp_eos_adj	0.712
s.dex_eos_adj	-0.386
p.crp_eos_adj	0.00111
p.dex_eos_adj	0.0772

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
AGO1	10039	-11639
TNRC6C	11322	-9642
TNRC6A	6069	-7296
TNRC6B	10292	-4086
AGO4	8888	-2865
AGO3	4582	-4205

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AGO1	10039	-11639
AGO2	7011	4852
AGO3	4582	-4205
AGO4	8888	-2865
TNRC6A	6069	-7296
TNRC6B	10292	-4086
TNRC6C	11322	-9642

---

---

Packaging Of Telomere Ends

Packaging Of Telomere Ends

metric	value
setSize	18
pMANOVA	8.15e-07
p.adjustMANOVA	6.79e-06
s.dist	0.81
s.crp_eos_adj	-0.698
s.dex_eos_adj	0.41
p.crp_eos_adj	2.9e-07
p.dex_eos_adj	0.00261

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
H2AC6	-10475	9891
H2BC21	-10433	9790
H2BC11	-10260	9781
H2BC12	-10075	9601
H2BC4	-9770	9809
H2BC9	-9292	9901
H2BC5	-9559	9491
H2BC17	-9549	9385
H2BC15	-8044	9295
H2AJ	-9644	3819
TINF2	-4189	2654

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ACD	-4589	-327
H2AC20	-9251	-2501
H2AC6	-10475	9891
H2AJ	-9644	3819
H2AZ2	-7006	-9940
H2BC11	-10260	9781
H2BC12	-10075	9601
H2BC15	-8044	9295
H2BC17	-9549	9385
H2BC21	-10433	9790
H2BC4	-9770	9809
H2BC5	-9559	9491
H2BC9	-9292	9901
POT1	-872	-6259
TERF1	-4045	-1651
TERF2	-953	-3416
TERF2IP	-1377	-1613
TINF2	-4189	2654

---

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

metric	value
setSize	59
pMANOVA	4e-26
p.adjustMANOVA	1.84e-24
s.dist	0.806
s.crp_eos_adj	-0.796
s.dex_eos_adj	0.122
p.crp_eos_adj	3.26e-26
p.dex_eos_adj	0.104

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
EIF4H	-8741	3960
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2S1	-4353	5718
EIF3H	-9904	2487
RPS14	-8103	2274
EIF2S3	-8788	1976
RPS27L	-8746	1792
EIF3A	-6825	2199
EIF3G	-8962	1578
PABPC1	-9588	1364

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4EBP1	-10212	1213
EIF4G1	781	8831
EIF4H	-8741	3960
FAU	-8965	528
PABPC1	-9588	1364
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	92
pMANOVA	1.16e-45
p.adjustMANOVA	1.12e-43
s.dist	0.805
s.crp_eos_adj	-0.805
s.dex_eos_adj	-0.0205
p.crp_eos_adj	9.69e-41
p.dex_eos_adj	0.734

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL13	-7350	-6766
RPL12	-9895	-4596
RPL27A	-9269	-4885
RPL22	-9607	-4134
RPL39L	-8440	-4668
RPL7	-10191	-3859
RPS17	-8643	-4422
RPS12	-8239	-4234
RPL31	-9467	-3680
RPS3A	-10096	-3399
RPS27A	-9093	-3694
RPLP1	-7065	-4669
RPL35	-9316	-3278
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS20	-10025	-2100
RPL36	-7435	-2774
RPL5	-10094	-2038
RPS13	-10206	-1877
RPL13A	-9486	-1976

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EEFSEC	-8495	-133
FAU	-8965	528
PSTK	-117	-1779
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
SARS1	-6944	-2110
SECISBP2	-1782	-3359
SEPHS2	1630	-844
SEPSECS	2235	-3052
UBA52	-9493	3637

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	94
pMANOVA	8.76e-45
p.adjustMANOVA	8.06e-43
s.dist	0.802
s.crp_eos_adj	-0.802
s.dex_eos_adj	0.0202
p.crp_eos_adj	2.37e-41
p.dex_eos_adj	0.735

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RPL22L1	-10142	5971
RPL26L1	-8789	4937
RPSA	-9568	4040
RPS4X	-10092	3529
RPL36AL	-6619	5375
UBA52	-9493	3637
RPS4Y1	-7140	3934
GSPT1	-2718	8704
RPL8	-9829	1920
RPS14	-8103	2274
RPL15	-9886	1682
NCBP2	-7940	2044
RPS27L	-8746	1792
UPF1	-2230	6638
RPL39	-9435	1424
PABPC1	-9588	1364
RPL7A	-9896	1278
ETF1	-2338	4540
RPL29	-10019	914
RPS11	-9343	895

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF4G1	781	8831
ETF1	-2338	4540
FAU	-8965	528
GSPT1	-2718	8704
GSPT2	-1663	-6497
NCBP1	-1910	3053
NCBP2	-7940	2044
PABPC1	-9588	1364
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
UBA52	-9493	3637
UPF1	-2230	6638

---

---

Translation initiation complex formation

Translation initiation complex formation

metric	value
setSize	58
pMANOVA	1.67e-25
p.adjustMANOVA	7.49e-24
s.dist	0.802
s.crp_eos_adj	-0.793
s.dex_eos_adj	0.121
p.crp_eos_adj	1.32e-25
p.dex_eos_adj	0.11

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
EIF4H	-8741	3960
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2S1	-4353	5718
EIF3H	-9904	2487
RPS14	-8103	2274
EIF2S3	-8788	1976
RPS27L	-8746	1792
EIF3A	-6825	2199
EIF3G	-8962	1578
PABPC1	-9588	1364

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4G1	781	8831
EIF4H	-8741	3960
FAU	-8965	528
PABPC1	-9588	1364
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040

---

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

metric	value
setSize	58
pMANOVA	2.22e-25
p.adjustMANOVA	9.74e-24
s.dist	0.801
s.crp_eos_adj	-0.791
s.dex_eos_adj	0.123
p.crp_eos_adj	1.66e-25
p.dex_eos_adj	0.106

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
EIF4A1	-9231	6226
EIF3J	-8886	6067
EIF3B	-8354	5747
EIF3M	-10392	3786
RPSA	-9568	4040
RPS4X	-10092	3529
EIF4H	-8741	3960
EIF1AX	-6420	5279
EIF4E	-5067	6356
RPS4Y1	-7140	3934
EIF3I	-9539	2929
EIF4B	-9349	2861
EIF2S1	-4353	5718
EIF3H	-9904	2487
EIF5	-8531	2193
RPS14	-8103	2274
EIF2S3	-8788	1976
RPS27L	-8746	1792
EIF3A	-6825	2199
EIF3G	-8962	1578

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
EIF1AX	-6420	5279
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
EIF3A	-6825	2199
EIF3B	-8354	5747
EIF3C	-7214	-6229
EIF3D	-9077	409
EIF3E	-9856	483
EIF3F	-6730	-3738
EIF3G	-8962	1578
EIF3H	-9904	2487
EIF3I	-9539	2929
EIF3J	-8886	6067
EIF3K	-9764	886
EIF3L	-9326	-958
EIF3M	-10392	3786
EIF4A1	-9231	6226
EIF4A2	-5246	1728
EIF4B	-9349	2861
EIF4E	-5067	6356
EIF4G1	781	8831
EIF4H	-8741	3960
EIF5	-8531	2193
FAU	-8965	528
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040

---

---

Mitochondrial translation elongation

Mitochondrial translation elongation

metric	value
setSize	90
pMANOVA	5.95e-40
p.adjustMANOVA	3.59e-38
s.dist	0.799
s.crp_eos_adj	-0.794
s.dex_eos_adj	0.0899
p.crp_eos_adj	7.27e-39
p.dex_eos_adj	0.14

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MRPL3	-10394	10140
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MRPL15	-10456	8814
MRPS17	-9267	6882
MRPS2	-8400	6472
MRPL36	-9299	5552
MRPL40	-9939	5084
MRPS30	-7284	6602
MRPS22	-10101	4669
MRPL32	-9897	4557
MRPL48	-9657	4635
MRPL24	-9310	4707
MRPS21	-10337	4159
MRPS27	-9511	4499
MRPS35	-9047	4638
MRPS16	-10323	3980
MRPS5	-9020	4506
MRPS15	-10133	3806
MRPL4	-8532	4487

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AURKAIP1	-7164	501
CHCHD1	-9555	-1062
DAP3	-10030	-741
ERAL1	-7967	-1507
GADD45GIP1	-9421	3582
GFM1	4522	2750
MRPL1	-6880	3433
MRPL10	-7219	1667
MRPL11	-9724	1300
MRPL12	-9705	-1578
MRPL13	-7769	-3257
MRPL14	-8517	-1654
MRPL15	-10456	8814
MRPL16	-9445	-561
MRPL17	-9915	766
MRPL18	-8752	-4188
MRPL19	-6743	1949
MRPL2	-5522	-10048
MRPL20	-9598	2373
MRPL21	-8109	4026
MRPL22	-7418	-568
MRPL23	-8376	-504
MRPL24	-9310	4707
MRPL27	-8987	-4004
MRPL28	-6206	-854
MRPL3	-10394	10140
MRPL30	-6130	-7501
MRPL32	-9897	4557
MRPL33	-7354	-5238
MRPL34	-9812	1838
MRPL35	-5552	-4517
MRPL36	-9299	5552
MRPL37	-10432	266
MRPL38	-7021	-94
MRPL39	-5938	-1075
MRPL4	-8532	4487
MRPL40	-9939	5084
MRPL41	-5086	-4089
MRPL42	-3938	-148
MRPL43	-7618	-4753
MRPL44	-9484	2065
MRPL45	-9715	-4705
MRPL46	-9617	-2776
MRPL47	-8493	2911
MRPL48	-9657	4635
MRPL49	-8603	2878
MRPL50	-1530	715
MRPL51	-10128	494
MRPL52	-9360	-1652
MRPL53	-9120	328
MRPL54	-9275	-6380
MRPL55	-8075	2046
MRPL57	-9894	-1393
MRPL58	-9021	306
MRPL9	-8852	14
MRPS10	-6117	596
MRPS11	-9136	-1480
MRPS14	-8020	-1134
MRPS15	-10133	3806
MRPS16	-10323	3980
MRPS17	-9267	6882
MRPS18A	-8450	1116
MRPS18B	-9491	1569
MRPS18C	-9473	-5773
MRPS2	-8400	6472
MRPS21	-10337	4159
MRPS22	-10101	4669
MRPS23	-8642	-2834
MRPS24	-8476	-2182
MRPS25	-6380	-8304
MRPS26	-8776	1907
MRPS27	-9511	4499
MRPS28	-10277	-653
MRPS30	-7284	6602
MRPS31	-5590	-1630
MRPS33	-7001	-8376
MRPS34	-7831	-372
MRPS35	-9047	4638
MRPS36	-6782	356
MRPS5	-9020	4506
MRPS6	3567	-11687
MRPS7	-10040	1776
MRPS9	-7312	-10532
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
OXA1L	-8898	-1994
PTCD3	-8573	3086
RPS12	-8239	-4234
TSFM	-9744	-6172
TUFM	-8625	416

---

---

G2 Phase

G2 Phase

metric	value
setSize	5
pMANOVA	0.0289
p.adjustMANOVA	0.0798
s.dist	0.794
s.crp_eos_adj	-0.51
s.dex_eos_adj	0.61
p.crp_eos_adj	0.0485
p.dex_eos_adj	0.0182

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
CCNA1	-6637	10050
E2F1	-10207	6459
CCNA2	-5239	3991
E2F3	-1580	9952

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
CCNA1	-6637	10050
CCNA2	-5239	3991
CDK2	-1922	-645
E2F1	-10207	6459
E2F3	-1580	9952

---

---

Mitochondrial translation termination

Mitochondrial translation termination

metric	value
setSize	90
pMANOVA	6.55e-39
p.adjustMANOVA	3.83e-37
s.dist	0.789
s.crp_eos_adj	-0.783
s.dex_eos_adj	0.09
p.crp_eos_adj	6.58e-38
p.dex_eos_adj	0.14

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MRPL3	-10394	10140
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MRPL15	-10456	8814
MRPS17	-9267	6882
MRPS2	-8400	6472
MRPL36	-9299	5552
MRPL40	-9939	5084
MRPS30	-7284	6602
MRPS22	-10101	4669
MRPL32	-9897	4557
MRPL48	-9657	4635
MRPL24	-9310	4707
MRPS21	-10337	4159
MRPS27	-9511	4499
MRPS35	-9047	4638
MRPS16	-10323	3980
MRPS5	-9020	4506
MRPS15	-10133	3806
MRPL4	-8532	4487

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AURKAIP1	-7164	501
CHCHD1	-9555	-1062
DAP3	-10030	-741
ERAL1	-7967	-1507
GADD45GIP1	-9421	3582
GFM2	-152	-2105
MRPL1	-6880	3433
MRPL10	-7219	1667
MRPL11	-9724	1300
MRPL12	-9705	-1578
MRPL13	-7769	-3257
MRPL14	-8517	-1654
MRPL15	-10456	8814
MRPL16	-9445	-561
MRPL17	-9915	766
MRPL18	-8752	-4188
MRPL19	-6743	1949
MRPL2	-5522	-10048
MRPL20	-9598	2373
MRPL21	-8109	4026
MRPL22	-7418	-568
MRPL23	-8376	-504
MRPL24	-9310	4707
MRPL27	-8987	-4004
MRPL28	-6206	-854
MRPL3	-10394	10140
MRPL30	-6130	-7501
MRPL32	-9897	4557
MRPL33	-7354	-5238
MRPL34	-9812	1838
MRPL35	-5552	-4517
MRPL36	-9299	5552
MRPL37	-10432	266
MRPL38	-7021	-94
MRPL39	-5938	-1075
MRPL4	-8532	4487
MRPL40	-9939	5084
MRPL41	-5086	-4089
MRPL42	-3938	-148
MRPL43	-7618	-4753
MRPL44	-9484	2065
MRPL45	-9715	-4705
MRPL46	-9617	-2776
MRPL47	-8493	2911
MRPL48	-9657	4635
MRPL49	-8603	2878
MRPL50	-1530	715
MRPL51	-10128	494
MRPL52	-9360	-1652
MRPL53	-9120	328
MRPL54	-9275	-6380
MRPL55	-8075	2046
MRPL57	-9894	-1393
MRPL58	-9021	306
MRPL9	-8852	14
MRPS10	-6117	596
MRPS11	-9136	-1480
MRPS14	-8020	-1134
MRPS15	-10133	3806
MRPS16	-10323	3980
MRPS17	-9267	6882
MRPS18A	-8450	1116
MRPS18B	-9491	1569
MRPS18C	-9473	-5773
MRPS2	-8400	6472
MRPS21	-10337	4159
MRPS22	-10101	4669
MRPS23	-8642	-2834
MRPS24	-8476	-2182
MRPS25	-6380	-8304
MRPS26	-8776	1907
MRPS27	-9511	4499
MRPS28	-10277	-653
MRPS30	-7284	6602
MRPS31	-5590	-1630
MRPS33	-7001	-8376
MRPS34	-7831	-372
MRPS35	-9047	4638
MRPS36	-6782	356
MRPS5	-9020	4506
MRPS6	3567	-11687
MRPS7	-10040	1776
MRPS9	-7312	-10532
MRRF	-8706	-4306
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
MTRF1L	5120	3514
OXA1L	-8898	-1994
PTCD3	-8573	3086
RPS12	-8239	-4234

---

---

Phosphate bond hydrolysis by NUDT proteins

Phosphate bond hydrolysis by NUDT proteins

metric	value
setSize	7
pMANOVA	0.00271
p.adjustMANOVA	0.0113
s.dist	0.782
s.crp_eos_adj	-0.749
s.dex_eos_adj	0.223
p.crp_eos_adj	0.000594
p.dex_eos_adj	0.306

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
NUDT16	-10284	10255
ADPRM	-9914	8395
NUDT15	-8717	5734
NUDT5	-7241	4383

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ADPRM	-9914	8395
NUDT1	-9396	-6389
NUDT15	-8717	5734
NUDT16	-10284	10255
NUDT18	-6891	-1366
NUDT5	-7241	4383
NUDT9	-1842	-9009

---

---

Mitochondrial translation

Mitochondrial translation

metric	value
setSize	96
pMANOVA	7.6e-41
p.adjustMANOVA	5.43e-39
s.dist	0.781
s.crp_eos_adj	-0.776
s.dex_eos_adj	0.0838
p.crp_eos_adj	1.31e-39
p.dex_eos_adj	0.156

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
MRPL3	-10394	10140
MT-RNR2	-10512	9583
MT-RNR1	-10513	9249
MRPL15	-10456	8814
MRPS17	-9267	6882
MRPS2	-8400	6472
MRPL36	-9299	5552
MRPL40	-9939	5084
MRPS30	-7284	6602
MRPS22	-10101	4669
MRPL32	-9897	4557
MRPL48	-9657	4635
MRPL24	-9310	4707
MRPS21	-10337	4159
MRPS27	-9511	4499
MRPS35	-9047	4638
MRPS16	-10323	3980
MRPS5	-9020	4506
MRPS15	-10133	3806
MRPL4	-8532	4487

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AURKAIP1	-7164	501
CHCHD1	-9555	-1062
DAP3	-10030	-741
ERAL1	-7967	-1507
GADD45GIP1	-9421	3582
GFM1	4522	2750
GFM2	-152	-2105
MRPL1	-6880	3433
MRPL10	-7219	1667
MRPL11	-9724	1300
MRPL12	-9705	-1578
MRPL13	-7769	-3257
MRPL14	-8517	-1654
MRPL15	-10456	8814
MRPL16	-9445	-561
MRPL17	-9915	766
MRPL18	-8752	-4188
MRPL19	-6743	1949
MRPL2	-5522	-10048
MRPL20	-9598	2373
MRPL21	-8109	4026
MRPL22	-7418	-568
MRPL23	-8376	-504
MRPL24	-9310	4707
MRPL27	-8987	-4004
MRPL28	-6206	-854
MRPL3	-10394	10140
MRPL30	-6130	-7501
MRPL32	-9897	4557
MRPL33	-7354	-5238
MRPL34	-9812	1838
MRPL35	-5552	-4517
MRPL36	-9299	5552
MRPL37	-10432	266
MRPL38	-7021	-94
MRPL39	-5938	-1075
MRPL4	-8532	4487
MRPL40	-9939	5084
MRPL41	-5086	-4089
MRPL42	-3938	-148
MRPL43	-7618	-4753
MRPL44	-9484	2065
MRPL45	-9715	-4705
MRPL46	-9617	-2776
MRPL47	-8493	2911
MRPL48	-9657	4635
MRPL49	-8603	2878
MRPL50	-1530	715
MRPL51	-10128	494
MRPL52	-9360	-1652
MRPL53	-9120	328
MRPL54	-9275	-6380
MRPL55	-8075	2046
MRPL57	-9894	-1393
MRPL58	-9021	306
MRPL9	-8852	14
MRPS10	-6117	596
MRPS11	-9136	-1480
MRPS14	-8020	-1134
MRPS15	-10133	3806
MRPS16	-10323	3980
MRPS17	-9267	6882
MRPS18A	-8450	1116
MRPS18B	-9491	1569
MRPS18C	-9473	-5773
MRPS2	-8400	6472
MRPS21	-10337	4159
MRPS22	-10101	4669
MRPS23	-8642	-2834
MRPS24	-8476	-2182
MRPS25	-6380	-8304
MRPS26	-8776	1907
MRPS27	-9511	4499
MRPS28	-10277	-653
MRPS30	-7284	6602
MRPS31	-5590	-1630
MRPS33	-7001	-8376
MRPS34	-7831	-372
MRPS35	-9047	4638
MRPS36	-6782	356
MRPS5	-9020	4506
MRPS6	3567	-11687
MRPS7	-10040	1776
MRPS9	-7312	-10532
MRRF	-8706	-4306
MT-RNR1	-10513	9249
MT-RNR2	-10512	9583
MTFMT	-8157	146
MTIF2	-9775	366
MTIF3	-8994	-2549
MTRF1L	5120	3514
OXA1L	-8898	-1994
PTCD3	-8573	3086
RPS12	-8239	-4234
TSFM	-9744	-6172
TUFM	-8625	416

---

---

Regulation of CDH11 mRNA translation by microRNAs

Regulation of CDH11 mRNA translation by microRNAs

metric	value
setSize	8
pMANOVA	0.00391
p.adjustMANOVA	0.0156
s.dist	0.779
s.crp_eos_adj	0.63
s.dex_eos_adj	-0.458
p.crp_eos_adj	0.00203
p.dex_eos_adj	0.0249

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
AGO1	10039	-11639
TNRC6C	11322	-9642
TNRC6A	6069	-7296
TNRC6B	10292	-4086
AGO4	8888	-2865
AGO3	4582	-4205
MOV10	1105	-11341

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AGO1	10039	-11639
AGO2	7011	4852
AGO3	4582	-4205
AGO4	8888	-2865
MOV10	1105	-11341
TNRC6A	6069	-7296
TNRC6B	10292	-4086
TNRC6C	11322	-9642

---

---

Regulation of NPAS4 mRNA translation

Regulation of NPAS4 mRNA translation

metric	value
setSize	8
pMANOVA	0.00391
p.adjustMANOVA	0.0156
s.dist	0.779
s.crp_eos_adj	0.63
s.dex_eos_adj	-0.458
p.crp_eos_adj	0.00203
p.dex_eos_adj	0.0249

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
AGO1	10039	-11639
TNRC6C	11322	-9642
TNRC6A	6069	-7296
TNRC6B	10292	-4086
AGO4	8888	-2865
AGO3	4582	-4205
MOV10	1105	-11341

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
AGO1	10039	-11639
AGO2	7011	4852
AGO3	4582	-4205
AGO4	8888	-2865
MOV10	1105	-11341
TNRC6A	6069	-7296
TNRC6B	10292	-4086
TNRC6C	11322	-9642

---

---

Replacement of protamines by nucleosomes in the male pronucleus

Replacement of protamines by nucleosomes in the male pronucleus

metric	value
setSize	13
pMANOVA	0.000152
p.adjustMANOVA	0.000863
s.dist	0.778
s.crp_eos_adj	-0.518
s.dex_eos_adj	0.58
p.crp_eos_adj	0.00121
p.dex_eos_adj	0.000291

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
H2BC21	-10433	9790
H2BC11	-10260	9781
H2BC12	-10075	9601
H2BC4	-9770	9809
H2BC9	-9292	9901
H2BC5	-9559	9491
H2BC17	-9549	9385
H2BC15	-8044	9295
H3-3A	-7627	7362
METTL23	-6474	325

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
H2BC11	-10260	9781
H2BC12	-10075	9601
H2BC15	-8044	9295
H2BC17	-9549	9385
H2BC21	-10433	9790
H2BC4	-9770	9809
H2BC5	-9559	9491
H2BC9	-9292	9901
H3-3A	-7627	7362
HIRA	4816	-8418
METTL23	-6474	325
NPM2	7624	-272
SRPK1	10891	-2771

---

---

Complex III assembly

Complex III assembly

metric	value
setSize	23
pMANOVA	4.08e-10
p.adjustMANOVA	5.84e-09
s.dist	0.765
s.crp_eos_adj	-0.762
s.dex_eos_adj	0.0632
p.crp_eos_adj	2.46e-10
p.dex_eos_adj	0.6

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
FXN	-10243	9335
MT-CYB	-7734	9007
UQCRC1	-8809	7511
UQCRH	-10424	4139
LETM1	-4667	8791
CYC1	-8948	4535
UQCRFS1	-8742	3672
UQCR10	-8058	3300
TTC19	-6617	1944
UQCR11	-9448	1176
HSPA9	-5919	1104

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
BCS1L	-6311	-1355
CYC1	-8948	4535
FXN	-10243	9335
HSCB	-10020	-9269
HSPA9	-5919	1104
ISCU	-8156	-3742
LETM1	-4667	8791
LYRM4	-9849	-2862
LYRM7	-2496	-7819
MT-CYB	-7734	9007
NFS1	-2128	-6880
TTC19	-6617	1944
UQCC1	-7796	-5936
UQCC2	-7906	-8737
UQCC3	-7500	-2002
UQCR10	-8058	3300
UQCR11	-9448	1176
UQCRB	-9949	-1912
UQCRC1	-8809	7511
UQCRC2	-10165	-2131
UQCRFS1	-8742	3672
UQCRH	-10424	4139
UQCRQ	-9529	-2952

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	100
pMANOVA	2.47e-43
p.adjustMANOVA	2.07e-41
s.dist	0.764
s.crp_eos_adj	-0.764
s.dex_eos_adj	0.0165
p.crp_eos_adj	5.87e-40
p.dex_eos_adj	0.776

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
ATF4	-10010	8024
RPL22L1	-10142	5971
DDIT3	-7887	5505
RPL26L1	-8789	4937
RPSA	-9568	4040
EIF2AK4	-9399	3792
RPS4X	-10092	3529
RPL36AL	-6619	5375
UBA52	-9493	3637
RPS4Y1	-7140	3934
EIF2S1	-4353	5718
RPL8	-9829	1920
RPS14	-8103	2274
EIF2S3	-8788	1976
RPL15	-9886	1682
RPS27L	-8746	1792
RPL39	-9435	1424
IMPACT	-6561	1956
RPL7A	-9896	1278
RPL29	-10019	914

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ASNS	8832	-6780
ATF2	-299	4933
ATF3	8369	-10864
ATF4	-10010	8024
CEBPB	7591	3735
CEBPG	-7797	215
DDIT3	-7887	5505
EIF2AK4	-9399	3792
EIF2S1	-4353	5718
EIF2S2	-8035	1063
EIF2S3	-8788	1976
FAU	-8965	528
GCN1	5856	3711
IMPACT	-6561	1956
RPL10	-9523	-1770
RPL10A	-9944	-711
RPL11	-9622	-613
RPL12	-9895	-4596
RPL13	-7350	-6766
RPL13A	-9486	-1976
RPL14	-9980	-1180
RPL15	-9886	1682
RPL17	-9570	-1849
RPL18	-9601	-1137
RPL18A	-9381	-419
RPL19	-9595	-952
RPL21	-9993	-1874
RPL22	-9607	-4134
RPL22L1	-10142	5971
RPL23	-9782	-1362
RPL23A	-9124	-580
RPL24	-10169	629
RPL26	-9748	-394
RPL26L1	-8789	4937
RPL27	-9880	74
RPL27A	-9269	-4885
RPL28	-7373	417
RPL29	-10019	914
RPL3	-8849	-1412
RPL30	-9556	407
RPL31	-9467	-3680
RPL32	-9632	579
RPL34	-9794	-1781
RPL35	-9316	-3278
RPL35A	-10182	-560
RPL36	-7435	-2774
RPL36A	-10049	-1758
RPL36AL	-6619	5375
RPL37	-8134	800
RPL37A	-9538	-1221
RPL38	-8566	-672
RPL39	-9435	1424
RPL39L	-8440	-4668
RPL3L	555	-5549
RPL4	-10113	-489
RPL41	-9415	161
RPL5	-10094	-2038
RPL6	-10001	-703
RPL7	-10191	-3859
RPL7A	-9896	1278
RPL8	-9829	1920
RPL9	-211	-4576
RPLP0	-9307	804
RPLP1	-7065	-4669
RPLP2	-7226	-2935
RPS10	-9274	-2281
RPS11	-9343	895
RPS12	-8239	-4234
RPS13	-10206	-1877
RPS14	-8103	2274
RPS15	-8796	-1813
RPS15A	-9864	438
RPS16	-6449	-295
RPS17	-8643	-4422
RPS18	-8329	-1569
RPS19	-9142	-900
RPS2	-7850	-2330
RPS20	-10025	-2100
RPS21	-6830	-2243
RPS23	-9737	-1610
RPS24	-9902	-1711
RPS25	-10003	-1821
RPS26	7854	-5464
RPS27	-9690	576
RPS27A	-9093	-3694
RPS27L	-8746	1792
RPS28	-6699	-253
RPS29	-7205	240
RPS3	-9514	39
RPS3A	-10096	-3399
RPS4X	-10092	3529
RPS4Y1	-7140	3934
RPS5	-8387	-414
RPS6	-9825	-1788
RPS7	-10200	-405
RPS8	-9928	-856
RPS9	-9546	341
RPSA	-9568	4040
TRIB3	-2986	-1493
UBA52	-9493	3637

---

---

RUNX1 regulates transcription of genes involved in BCR signaling

RUNX1 regulates transcription of genes involved in BCR signaling

metric	value
setSize	6
pMANOVA	0.000496
p.adjustMANOVA	0.00248
s.dist	0.764
s.crp_eos_adj	0.338
s.dex_eos_adj	0.685
p.crp_eos_adj	0.152
p.dex_eos_adj	0.00368

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
RUNX1	11174	5720
ELF2	8487	6435
PAX5	6250	5756
ELF1	868	9009
CBFB	167	5290

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
BLK	-1727	8508
CBFB	167	5290
ELF1	868	9009
ELF2	8487	6435
PAX5	6250	5756
RUNX1	11174	5720

---

---

Arachidonate production from DAG

Arachidonate production from DAG

metric	value
setSize	5
pMANOVA	0.0145
p.adjustMANOVA	0.0455
s.dist	0.754
s.crp_eos_adj	-0.741
s.dex_eos_adj	0.141
p.crp_eos_adj	0.0041
p.dex_eos_adj	0.586

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
ABHD6	-10225	10194
MGLL	-9860	8492
ABHD12	-10051	93

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ABHD12	-10051	93
ABHD6	-10225	10194
DAGLA	-1899	-11581
DAGLB	-6292	-3166
MGLL	-9860	8492

---

---

CD163 mediating an anti-inflammatory response

CD163 mediating an anti-inflammatory response

metric	value
setSize	9
pMANOVA	0.00013
p.adjustMANOVA	0.000746
s.dist	0.753
s.crp_eos_adj	0.032
s.dex_eos_adj	0.752
p.crp_eos_adj	0.868
p.dex_eos_adj	9.37e-05

Top 20 genes

Gene	crp_eos_adj	dex_eos_adj
IL10	10610	8866
FURIN	6117	9002
MYH9	2075	8162
MAPK14	10774	1556
IL6	1369	4947

Click HERE to show all gene set members

All member genes

	crp_eos_adj	dex_eos_adj
ADAM17	-5973	9713
CD163	-10147	10250
FURIN	6117	9002
IL10	10610	8866
IL6	1369	4947
MAPK14	10774	1556
MYH9	2075	8162
PLK2	-2796	5596
RHBDF2	-4486	9629

---

---

Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## Network charts only generated in one-dimensional analysis.

Session information

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] gtools_3.9.5                RhpcBLASctl_0.23-42        
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] eulerr_7.1.0                ggplot2_4.0.3              
##  [7] kableExtra_1.4.0            MASS_7.3-65                
##  [9] mitch_1.22.1                DESeq2_1.50.2              
## [11] SummarizedExperiment_1.40.0 Biobase_2.70.0             
## [13] MatrixGenerics_1.22.0       matrixStats_1.5.0          
## [15] GenomicRanges_1.62.1        Seqinfo_1.0.0              
## [17] IRanges_2.44.0              S4Vectors_0.48.1           
## [19] BiocGenerics_0.56.0         generics_0.1.4             
## [21] dplyr_1.2.1                 WGCNA_1.74                 
## [23] fastcluster_1.3.0           dynamicTreeCut_1.63-1      
## [25] reshape2_1.4.5              gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] Hmisc_5.2-5           labeling_0.4.3        polyclip_1.10-7      
##  [37] abind_1.4-8           compiler_4.5.2        withr_3.0.2          
##  [40] doParallel_1.0.17     htmlTable_2.5.0       S7_0.2.2             
##  [43] backports_1.5.1       BiocParallel_1.44.0   ggstats_0.13.0       
##  [46] DelayedArray_0.36.1   caTools_1.18.3        tools_4.5.2          
##  [49] foreign_0.8-90        otel_0.2.0            beeswarm_0.4.0       
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.4     xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report