date generated: 2026-04-24

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
crp_eos_adj dex_eos_adj
5_8S_rRNA -2.4785771 2.3372330
A1BG -1.7542511 -0.1044447
A1BG-AS1 -1.0734377 0.3112347
A1CF 0.5521424 0.9717804
A2M 1.6603819 2.6139639
A2M-AS1 1.3818491 2.4240591

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 21999
duplicated_genes_present 0
num_profile_genes_in_sets 8829
num_profile_genes_not_in_sets 13170
profile_pearson_correl -0.3949
profile_spearman_correl -0.34706

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2725
num_genesets_excluded 1188
num_genesets_included 1537

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 627

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.crp_eos_adj s.dex_eos_adj p.crp_eos_adj p.dex_eos_adj
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 6.31e-10 8.64e-09 1.000 -0.727 0.687000 4.07e-08 2.15e-07
Formation of the ureteric bud 5 4.30e-03 1.68e-02 0.959 -0.492 0.824000 5.69e-02 1.42e-03
Modulation by Mtb of host immune system 7 4.97e-04 2.48e-03 0.955 -0.826 0.478000 1.53e-04 2.84e-02
Mitochondrial RNA degradation 25 8.44e-11 1.35e-09 0.911 -0.684 0.602000 3.17e-09 1.91e-07
Defective binding of VWF variant to GPIb:IX:V 7 1.46e-03 6.56e-03 0.906 -0.544 0.724000 1.27e-02 9.04e-04
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.46e-03 6.56e-03 0.906 -0.544 0.724000 1.27e-02 9.04e-04
Formation of ATP by chemiosmotic coupling 20 3.29e-10 4.82e-09 0.898 -0.853 0.282000 3.91e-11 2.90e-02
Protein repair 6 4.41e-03 1.72e-02 0.880 -0.477 0.740000 4.30e-02 1.70e-03
MECP2 regulates transcription of neuronal ligands 5 1.21e-02 3.94e-02 0.869 0.468 -0.733000 7.02e-02 4.53e-03
tRNA processing in the mitochondrion 24 3.66e-09 4.36e-08 0.851 -0.636 0.566000 6.94e-08 1.57e-06
RNA Polymerase I Promoter Opening 17 1.03e-06 8.36e-06 0.844 -0.676 0.506000 1.39e-06 3.01e-04
Peptide chain elongation 88 1.41e-47 1.60e-45 0.843 -0.843 -0.014000 1.15e-42 8.21e-01
Formation of a pool of free 40S subunits 100 1.17e-52 1.88e-50 0.843 -0.842 0.016000 3.11e-48 7.83e-01
Eukaryotic Translation Elongation 93 1.90e-49 2.45e-47 0.835 -0.834 -0.017600 3.70e-44 7.69e-01
Tandem pore domain potassium channels 5 1.83e-02 5.46e-02 0.831 0.463 -0.690000 7.29e-02 7.50e-03
Viral mRNA Translation 88 9.47e-46 9.63e-44 0.831 -0.831 0.000516 1.49e-41 9.93e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.15e-54 8.03e-52 0.828 -0.826 0.054000 6.06e-51 3.28e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.46e-02 4.58e-02 0.824 -0.744 0.356000 3.98e-03 1.68e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 4.92e-54 8.63e-52 0.824 -0.822 0.053200 7.35e-51 3.33e-01
Formation of xylulose-5-phosphate 5 4.22e-04 2.15e-03 0.823 -0.602 -0.560000 1.97e-02 3.00e-02
SARS-CoV-1 modulates host translation machinery 36 1.55e-18 5.53e-17 0.819 -0.819 0.005170 1.72e-17 9.57e-01
Cap-dependent Translation Initiation 118 5.82e-57 1.25e-54 0.818 -0.817 0.045400 2.87e-53 3.95e-01
Eukaryotic Translation Initiation 118 5.82e-57 1.25e-54 0.818 -0.817 0.045400 2.87e-53 3.95e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 2.55e-24 1.07e-22 0.816 -0.813 0.072700 9.14e-24 3.69e-01
Interleukin-21 signaling 9 1.24e-03 5.67e-03 0.814 0.628 -0.517000 1.11e-03 7.18e-03
Mitochondrial translation initiation 90 2.71e-41 2.02e-39 0.812 -0.807 0.090900 4.02e-40 1.36e-01
G2/M DNA replication checkpoint 5 2.54e-02 7.21e-02 0.812 -0.551 0.596000 3.28e-02 2.10e-02
rRNA processing in the mitochondrion 24 1.03e-08 1.17e-07 0.811 -0.680 0.442000 7.81e-09 1.79e-04
SRP-dependent cotranslational protein targeting to membrane 111 1.20e-50 1.66e-48 0.810 -0.805 0.088100 6.90e-49 1.09e-01
Eukaryotic Translation Termination 92 5.57e-46 5.98e-44 0.810 -0.810 -0.013800 2.94e-41 8.19e-01
Post-transcriptional silencing by small RNAs 7 3.89e-03 1.56e-02 0.810 0.712 -0.386000 1.11e-03 7.72e-02
Packaging Of Telomere Ends 18 8.15e-07 6.79e-06 0.810 -0.698 0.410000 2.90e-07 2.61e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.00e-26 1.84e-24 0.806 -0.796 0.122000 3.26e-26 1.04e-01
Selenocysteine synthesis 92 1.16e-45 1.12e-43 0.805 -0.805 -0.020500 9.69e-41 7.34e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 8.76e-45 8.06e-43 0.802 -0.802 0.020200 2.37e-41 7.35e-01
Translation initiation complex formation 58 1.67e-25 7.49e-24 0.802 -0.793 0.121000 1.32e-25 1.10e-01
Ribosomal scanning and start codon recognition 58 2.22e-25 9.75e-24 0.801 -0.791 0.123000 1.66e-25 1.06e-01
Mitochondrial translation elongation 90 5.95e-40 3.59e-38 0.799 -0.794 0.089900 7.27e-39 1.40e-01
G2 Phase 5 2.89e-02 7.98e-02 0.794 -0.510 0.610000 4.85e-02 1.82e-02
Mitochondrial translation termination 90 6.55e-39 3.83e-37 0.789 -0.783 0.090000 6.58e-38 1.40e-01
Phosphate bond hydrolysis by NUDT proteins 7 2.71e-03 1.13e-02 0.782 -0.749 0.223000 5.94e-04 3.06e-01
Mitochondrial translation 96 7.60e-41 5.43e-39 0.781 -0.776 0.083900 1.31e-39 1.56e-01
Regulation of CDH11 mRNA translation by microRNAs 8 3.91e-03 1.56e-02 0.779 0.630 -0.458000 2.03e-03 2.49e-02
Regulation of NPAS4 mRNA translation 8 3.91e-03 1.56e-02 0.779 0.630 -0.458000 2.03e-03 2.49e-02
Replacement of protamines by nucleosomes in the male pronucleus 13 1.52e-04 8.63e-04 0.778 -0.518 0.580000 1.21e-03 2.91e-04
Complex III assembly 23 4.08e-10 5.84e-09 0.765 -0.762 0.063300 2.46e-10 5.99e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 2.47e-43 2.07e-41 0.764 -0.764 0.016500 5.86e-40 7.76e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 4.97e-04 2.48e-03 0.763 0.338 0.685000 1.52e-01 3.68e-03
Arachidonate production from DAG 5 1.45e-02 4.55e-02 0.754 -0.741 0.141000 4.10e-03 5.86e-01
CD163 mediating an anti-inflammatory response 9 1.30e-04 7.46e-04 0.753 0.032 0.752000 8.68e-01 9.37e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.crp_eos_adj s.dex_eos_adj p.crp_eos_adj p.dex_eos_adj
FASTK family proteins regulate processing and stability of mitochondrial RNAs 19 6.31e-10 8.64e-09 1.00000 -7.27e-01 6.87e-01 4.07e-08 2.15e-07
Formation of the ureteric bud 5 4.30e-03 1.68e-02 0.95900 -4.92e-01 8.24e-01 5.69e-02 1.42e-03
Modulation by Mtb of host immune system 7 4.97e-04 2.48e-03 0.95500 -8.26e-01 4.78e-01 1.53e-04 2.84e-02
Mitochondrial RNA degradation 25 8.44e-11 1.35e-09 0.91100 -6.84e-01 6.02e-01 3.17e-09 1.91e-07
Defective binding of VWF variant to GPIb:IX:V 7 1.46e-03 6.56e-03 0.90600 -5.44e-01 7.24e-01 1.27e-02 9.04e-04
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 1.46e-03 6.56e-03 0.90600 -5.44e-01 7.24e-01 1.27e-02 9.04e-04
Formation of ATP by chemiosmotic coupling 20 3.29e-10 4.82e-09 0.89800 -8.53e-01 2.82e-01 3.91e-11 2.90e-02
Protein repair 6 4.41e-03 1.72e-02 0.88000 -4.77e-01 7.40e-01 4.30e-02 1.70e-03
MECP2 regulates transcription of neuronal ligands 5 1.21e-02 3.94e-02 0.86900 4.68e-01 -7.33e-01 7.02e-02 4.53e-03
tRNA processing in the mitochondrion 24 3.66e-09 4.36e-08 0.85100 -6.36e-01 5.66e-01 6.94e-08 1.57e-06
RNA Polymerase I Promoter Opening 17 1.03e-06 8.36e-06 0.84400 -6.76e-01 5.06e-01 1.39e-06 3.01e-04
Peptide chain elongation 88 1.41e-47 1.60e-45 0.84300 -8.43e-01 -1.40e-02 1.15e-42 8.21e-01
Formation of a pool of free 40S subunits 100 1.17e-52 1.88e-50 0.84300 -8.42e-01 1.60e-02 3.11e-48 7.83e-01
Eukaryotic Translation Elongation 93 1.90e-49 2.45e-47 0.83500 -8.34e-01 -1.76e-02 3.70e-44 7.69e-01
Tandem pore domain potassium channels 5 1.83e-02 5.46e-02 0.83100 4.63e-01 -6.90e-01 7.29e-02 7.50e-03
Viral mRNA Translation 88 9.47e-46 9.63e-44 0.83100 -8.31e-01 5.16e-04 1.49e-41 9.93e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.15e-54 8.03e-52 0.82800 -8.26e-01 5.40e-02 6.06e-51 3.28e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 1.46e-02 4.58e-02 0.82400 -7.44e-01 3.56e-01 3.98e-03 1.68e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 4.92e-54 8.63e-52 0.82400 -8.22e-01 5.32e-02 7.35e-51 3.33e-01
Formation of xylulose-5-phosphate 5 4.22e-04 2.15e-03 0.82300 -6.02e-01 -5.60e-01 1.97e-02 3.00e-02
SARS-CoV-1 modulates host translation machinery 36 1.55e-18 5.53e-17 0.81900 -8.19e-01 5.17e-03 1.72e-17 9.57e-01
Cap-dependent Translation Initiation 118 5.82e-57 1.25e-54 0.81800 -8.17e-01 4.54e-02 2.87e-53 3.95e-01
Eukaryotic Translation Initiation 118 5.82e-57 1.25e-54 0.81800 -8.17e-01 4.54e-02 2.87e-53 3.95e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 2.55e-24 1.07e-22 0.81600 -8.13e-01 7.27e-02 9.14e-24 3.69e-01
Interleukin-21 signaling 9 1.24e-03 5.67e-03 0.81400 6.28e-01 -5.17e-01 1.11e-03 7.18e-03
Mitochondrial translation initiation 90 2.71e-41 2.02e-39 0.81200 -8.07e-01 9.09e-02 4.02e-40 1.36e-01
G2/M DNA replication checkpoint 5 2.54e-02 7.21e-02 0.81200 -5.51e-01 5.96e-01 3.28e-02 2.10e-02
rRNA processing in the mitochondrion 24 1.03e-08 1.17e-07 0.81100 -6.80e-01 4.42e-01 7.81e-09 1.79e-04
SRP-dependent cotranslational protein targeting to membrane 111 1.20e-50 1.66e-48 0.81000 -8.05e-01 8.81e-02 6.90e-49 1.09e-01
Eukaryotic Translation Termination 92 5.57e-46 5.98e-44 0.81000 -8.10e-01 -1.38e-02 2.94e-41 8.19e-01
Post-transcriptional silencing by small RNAs 7 3.89e-03 1.56e-02 0.81000 7.12e-01 -3.86e-01 1.11e-03 7.72e-02
Packaging Of Telomere Ends 18 8.15e-07 6.79e-06 0.81000 -6.98e-01 4.10e-01 2.90e-07 2.61e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.00e-26 1.84e-24 0.80600 -7.96e-01 1.22e-01 3.26e-26 1.04e-01
Selenocysteine synthesis 92 1.16e-45 1.12e-43 0.80500 -8.05e-01 -2.05e-02 9.69e-41 7.34e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 8.76e-45 8.06e-43 0.80200 -8.02e-01 2.02e-02 2.37e-41 7.35e-01
Translation initiation complex formation 58 1.67e-25 7.49e-24 0.80200 -7.93e-01 1.21e-01 1.32e-25 1.10e-01
Ribosomal scanning and start codon recognition 58 2.22e-25 9.75e-24 0.80100 -7.91e-01 1.23e-01 1.66e-25 1.06e-01
Mitochondrial translation elongation 90 5.95e-40 3.59e-38 0.79900 -7.94e-01 8.99e-02 7.27e-39 1.40e-01
G2 Phase 5 2.89e-02 7.98e-02 0.79400 -5.10e-01 6.10e-01 4.85e-02 1.82e-02
Mitochondrial translation termination 90 6.55e-39 3.83e-37 0.78900 -7.83e-01 9.00e-02 6.58e-38 1.40e-01
Phosphate bond hydrolysis by NUDT proteins 7 2.71e-03 1.13e-02 0.78200 -7.49e-01 2.23e-01 5.94e-04 3.06e-01
Mitochondrial translation 96 7.60e-41 5.43e-39 0.78100 -7.76e-01 8.39e-02 1.31e-39 1.56e-01
Regulation of CDH11 mRNA translation by microRNAs 8 3.91e-03 1.56e-02 0.77900 6.30e-01 -4.58e-01 2.03e-03 2.49e-02
Regulation of NPAS4 mRNA translation 8 3.91e-03 1.56e-02 0.77900 6.30e-01 -4.58e-01 2.03e-03 2.49e-02
Replacement of protamines by nucleosomes in the male pronucleus 13 1.52e-04 8.63e-04 0.77800 -5.18e-01 5.80e-01 1.21e-03 2.91e-04
Complex III assembly 23 4.08e-10 5.84e-09 0.76500 -7.62e-01 6.33e-02 2.46e-10 5.99e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 2.47e-43 2.07e-41 0.76400 -7.64e-01 1.65e-02 5.86e-40 7.76e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 4.97e-04 2.48e-03 0.76300 3.38e-01 6.85e-01 1.52e-01 3.68e-03
Arachidonate production from DAG 5 1.45e-02 4.55e-02 0.75400 -7.41e-01 1.41e-01 4.10e-03 5.86e-01
CD163 mediating an anti-inflammatory response 9 1.30e-04 7.46e-04 0.75300 3.20e-02 7.52e-01 8.68e-01 9.37e-05
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 20 3.33e-06 2.55e-05 0.74800 -5.82e-01 4.71e-01 6.70e-06 2.64e-04
CD22 mediated BCR regulation 58 4.01e-16 1.25e-14 0.74100 -5.35e-01 5.13e-01 1.78e-12 1.37e-11
Regulation of NPAS4 gene expression 11 1.00e-03 4.69e-03 0.73800 6.08e-01 -4.18e-01 4.76e-04 1.65e-02
Translation 293 1.22e-109 2.36e-106 0.73500 -7.32e-01 7.43e-02 5.07e-104 2.86e-02
SIRT1 negatively regulates rRNA expression 22 9.91e-07 8.11e-06 0.73500 -6.15e-01 4.03e-01 5.86e-07 1.07e-03
Cleavage of the damaged purine 22 3.98e-07 3.47e-06 0.73500 -6.61e-01 3.21e-01 7.86e-08 9.09e-03
Depurination 22 3.98e-07 3.47e-06 0.73500 -6.61e-01 3.21e-01 7.86e-08 9.09e-03
Recognition and association of DNA glycosylase with site containing an affected purine 22 3.98e-07 3.47e-06 0.73500 -6.61e-01 3.21e-01 7.86e-08 9.09e-03
SARS-CoV-2 modulates host translation machinery 49 1.53e-20 5.80e-19 0.73100 -7.30e-01 -2.43e-02 8.67e-19 7.69e-01
MET activates PI3K/AKT signaling 5 2.45e-03 1.04e-02 0.72800 5.88e-01 4.29e-01 2.28e-02 9.64e-02
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 6.12e-03 2.25e-02 0.72700 -6.96e-01 2.10e-01 1.43e-03 3.37e-01
Cristae formation 33 1.57e-11 2.83e-10 0.72400 -7.04e-01 1.67e-01 2.45e-12 9.61e-02
Mitochondrial calcium ion transport 22 7.44e-08 7.33e-07 0.71800 -7.00e-01 1.60e-01 1.31e-08 1.93e-01
TGFBR3 expression 20 8.62e-06 6.21e-05 0.71400 5.80e-01 -4.15e-01 6.96e-06 1.30e-03
Selenoamino acid metabolism 115 7.30e-44 6.41e-42 0.71300 -7.13e-01 2.31e-03 5.91e-40 9.66e-01
Classical antibody-mediated complement activation 69 1.39e-17 4.80e-16 0.70900 -5.41e-01 4.58e-01 7.36e-15 4.82e-11
Synthesis of PI 5 6.07e-02 1.40e-01 0.70800 4.70e-01 -5.30e-01 6.89e-02 4.02e-02
Defects of platelet adhesion to exposed collagen 8 1.16e-02 3.81e-02 0.69900 -4.14e-01 5.63e-01 4.25e-02 5.78e-03
p130Cas linkage to MAPK signaling for integrins 11 1.97e-03 8.52e-03 0.69800 -5.84e-01 3.82e-01 7.95e-04 2.83e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 9.56e-41 6.16e-39 0.68900 -6.89e-01 3.13e-04 3.99e-37 9.95e-01
Nonsense-Mediated Decay (NMD) 114 9.56e-41 6.16e-39 0.68900 -6.89e-01 3.13e-04 3.99e-37 9.95e-01
DNA methylation 18 5.03e-05 3.21e-04 0.68800 -5.74e-01 3.80e-01 2.46e-05 5.29e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.07e-03 4.98e-03 0.68700 -5.05e-01 4.66e-01 1.62e-03 3.65e-03
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 1.50e-02 4.68e-02 0.68600 -6.84e-01 -4.73e-02 8.05e-03 8.55e-01
Propionyl-CoA catabolism 5 5.89e-03 2.19e-02 0.68500 -3.14e-01 -6.09e-01 2.24e-01 1.83e-02
Cation-coupled Chloride cotransporters 6 3.42e-02 9.16e-02 0.68400 5.98e-01 -3.33e-01 1.12e-02 1.58e-01
Scavenging of heme from plasma 70 1.63e-16 5.25e-15 0.68200 -5.10e-01 4.53e-01 1.49e-13 5.66e-11
Processing of SMDT1 15 3.86e-06 2.90e-05 0.68200 -6.80e-01 -4.75e-02 5.06e-06 7.50e-01
rRNA processing 213 5.26e-65 2.54e-62 0.67900 -6.69e-01 1.11e-01 5.14e-64 5.11e-03
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.55e-57 7.03e-55 0.67800 -6.74e-01 6.67e-02 6.86e-55 1.24e-01
Complex I biogenesis 66 2.09e-21 8.09e-20 0.67000 -6.68e-01 5.57e-02 5.80e-21 4.34e-01
Regulation of expression of SLITs and ROBOs 149 9.33e-48 1.13e-45 0.67000 -6.68e-01 4.74e-02 3.07e-45 3.18e-01
rRNA processing in the nucleus and cytosol 189 5.86e-59 1.89e-56 0.67000 -6.66e-01 6.88e-02 1.50e-56 1.03e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 7.00e-03 2.50e-02 0.66600 -4.41e-01 5.00e-01 1.58e-02 6.21e-03
Response to metal ions 6 5.15e-02 1.24e-01 0.66500 -4.43e-01 4.96e-01 6.00e-02 3.54e-02
Creation of C4 and C2 activators 71 4.79e-16 1.45e-14 0.66500 -5.14e-01 4.23e-01 6.88e-14 7.28e-10
Regulation of NFE2L2 gene expression 8 7.13e-03 2.53e-02 0.66300 6.40e-01 -1.72e-01 1.73e-03 3.99e-01
Glucuronidation 9 1.26e-02 4.08e-02 0.66100 -4.73e-01 4.61e-01 1.39e-02 1.66e-02
PINK1-PRKN Mediated Mitophagy 31 1.40e-07 1.32e-06 0.65900 -5.59e-01 3.48e-01 6.98e-08 7.99e-04
Formation of the active cofactor, UDP-glucuronate 5 8.93e-02 1.88e-01 0.65900 -4.58e-01 4.73e-01 7.61e-02 6.68e-02
ATF6 (ATF6-alpha) activates chaperones 12 3.05e-03 1.25e-02 0.65800 -4.52e-01 4.79e-01 6.72e-03 4.09e-03
HDMs demethylate histones 22 3.77e-06 2.85e-05 0.65600 6.15e-01 -2.27e-01 5.84e-07 6.50e-02
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 6.63e-03 2.39e-02 0.65400 -6.39e-01 -1.41e-01 6.73e-03 5.50e-01
Recycling of eIF2:GDP 8 3.10e-03 1.27e-02 0.65400 -6.54e-01 9.57e-03 1.36e-03 9.63e-01
PDH complex synthesizes acetyl-CoA from PYR 5 5.28e-02 1.26e-01 0.65200 -6.25e-01 1.86e-01 1.54e-02 4.72e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 3.11e-02 8.43e-02 0.65000 -6.21e-01 1.95e-01 8.47e-03 4.09e-01
Mitochondrial protein import 63 1.01e-18 3.67e-17 0.64900 -6.45e-01 7.96e-02 8.36e-19 2.75e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 9.00e-11 1.40e-09 0.64600 -6.26e-01 1.60e-01 1.29e-11 8.34e-02
p53-Independent DNA Damage Response 39 9.00e-11 1.40e-09 0.64600 -6.26e-01 1.60e-01 1.29e-11 8.34e-02
p53-Independent G1/S DNA damage checkpoint 39 9.00e-11 1.40e-09 0.64600 -6.26e-01 1.60e-01 1.29e-11 8.34e-02
Inhibition of DNA recombination at telomere 33 2.84e-08 3.00e-07 0.64400 -5.90e-01 2.57e-01 4.38e-09 1.06e-02
Vif-mediated degradation of APOBEC3G 41 5.49e-11 9.31e-10 0.64200 -6.19e-01 1.73e-01 7.06e-12 5.49e-02
Respiratory electron transport 149 9.65e-43 7.45e-41 0.63900 -6.36e-01 5.95e-02 4.25e-41 2.10e-01
Sulfide oxidation to sulfate 5 1.59e-02 4.93e-02 0.63600 -6.07e-01 -1.92e-01 1.88e-02 4.57e-01
Regulation of Expression and Function of Type II Classical Cadherins 25 9.69e-06 6.86e-05 0.63400 5.19e-01 -3.64e-01 6.93e-06 1.63e-03
Regulation of Homotypic Cell-Cell Adhesion 25 9.69e-06 6.86e-05 0.63400 5.19e-01 -3.64e-01 6.93e-06 1.63e-03
Chromatin modifications during the maternal to zygotic transition (MZT) 23 2.99e-05 1.99e-04 0.63300 -3.87e-01 5.01e-01 1.32e-03 3.24e-05
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 3.00e-02 8.20e-02 0.63000 -6.30e-01 -3.14e-02 1.47e-02 9.03e-01
Cleavage of the damaged pyrimidine 27 1.95e-06 1.52e-05 0.63000 -5.62e-01 2.87e-01 4.37e-07 9.95e-03
Depyrimidination 27 1.95e-06 1.52e-05 0.63000 -5.62e-01 2.87e-01 4.37e-07 9.95e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 27 1.95e-06 1.52e-05 0.63000 -5.62e-01 2.87e-01 4.37e-07 9.95e-03
CDH11 homotypic and heterotypic interactions 6 6.96e-02 1.55e-01 0.62900 4.86e-01 -3.99e-01 3.94e-02 9.06e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 37 1.63e-09 2.11e-08 0.62800 -6.03e-01 1.76e-01 2.14e-10 6.33e-02
Assembly of the ORC complex at the origin of replication 23 2.36e-05 1.60e-04 0.62800 -5.34e-01 3.30e-01 9.29e-06 6.07e-03
CYP2E1 reactions 6 7.26e-02 1.60e-01 0.62600 4.64e-01 -4.19e-01 4.89e-02 7.52e-02
Maturation of TCA enzymes and regulation of TCA cycle 20 1.57e-06 1.25e-05 0.62500 -6.25e-01 -3.78e-03 1.31e-06 9.77e-01
NADE modulates death signalling 5 1.01e-01 2.04e-01 0.62400 -5.34e-01 3.23e-01 3.88e-02 2.12e-01
Maturation of spike protein 9683686 5 8.83e-02 1.86e-01 0.62300 -5.64e-01 2.63e-01 2.88e-02 3.09e-01
Base-Excision Repair, AP Site Formation 29 7.17e-07 6.02e-06 0.62200 -5.67e-01 2.56e-01 1.24e-07 1.71e-02
Vpu mediated degradation of CD4 39 1.78e-10 2.67e-09 0.62100 -6.11e-01 1.14e-01 3.98e-11 2.17e-01
Regulation of CDH11 Expression and Function 23 3.52e-05 2.33e-04 0.62100 5.15e-01 -3.47e-01 1.89e-05 4.00e-03
Cellular response to mitochondrial stress 9 3.13e-03 1.28e-02 0.62100 -6.20e-01 2.16e-02 1.27e-03 9.10e-01
POLB-Dependent Long Patch Base Excision Repair 8 1.29e-03 5.90e-03 0.62000 -2.66e-01 -5.60e-01 1.93e-01 6.08e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.39e-02 4.44e-02 0.61900 -4.27e-01 4.49e-01 1.95e-02 1.39e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 1.38e-10 2.11e-09 0.61700 -6.02e-01 1.32e-01 2.45e-11 1.43e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 5.79e-04 2.86e-03 0.61600 -6.15e-01 -4.08e-02 4.11e-04 8.15e-01
Influenza Viral RNA Transcription and Replication 135 1.63e-40 1.01e-38 0.61400 -6.12e-01 -5.20e-02 1.03e-34 2.97e-01
Folding of actin by CCT/TriC 10 4.14e-03 1.63e-02 0.61400 -5.99e-01 1.31e-01 1.03e-03 4.72e-01
RNA Polymerase I Promoter Escape 45 8.03e-10 1.09e-08 0.60900 -5.53e-01 2.56e-01 1.33e-10 2.99e-03
Hh mutants are degraded by ERAD 42 1.02e-09 1.35e-08 0.60900 -5.74e-01 2.05e-01 1.23e-10 2.18e-02
Defective CFTR causes cystic fibrosis 47 6.95e-11 1.13e-09 0.60800 -5.76e-01 1.95e-01 7.96e-12 2.10e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 42 5.67e-10 7.82e-09 0.60700 -5.81e-01 1.77e-01 7.09e-11 4.73e-02
Cellular response to starvation 148 2.41e-37 1.29e-35 0.60700 -6.02e-01 7.89e-02 1.06e-36 9.74e-02
Proteasome assembly 50 4.07e-13 9.95e-12 0.60500 -6.00e-01 7.38e-02 2.03e-13 3.67e-01
Apoptosis induced DNA fragmentation 10 1.38e-02 4.43e-02 0.60400 -5.12e-01 3.20e-01 5.02e-03 7.97e-02
Mitochondrial iron-sulfur cluster biogenesis 13 1.20e-04 6.95e-04 0.60400 -5.95e-01 -1.03e-01 2.02e-04 5.21e-01
Hedgehog ligand biogenesis 47 4.99e-10 6.94e-09 0.60300 -5.48e-01 2.51e-01 8.09e-11 2.86e-03
Regulation of Apoptosis 40 2.02e-09 2.55e-08 0.60300 -5.77e-01 1.73e-01 2.62e-10 5.82e-02
Ubiquitin-dependent degradation of Cyclin D 39 1.31e-09 1.71e-08 0.60200 -5.87e-01 1.33e-01 2.25e-10 1.52e-01
NRIF signals cell death from the nucleus 15 1.71e-03 7.53e-03 0.60100 -5.12e-01 3.13e-01 5.90e-04 3.57e-02
Regulation of ornithine decarboxylase (ODC) 38 5.71e-09 6.56e-08 0.60000 -5.76e-01 1.67e-01 7.74e-10 7.45e-02
Regulation of CDH11 gene transcription 5 1.33e-01 2.49e-01 0.60000 3.82e-01 -4.62e-01 1.39e-01 7.37e-02
RNA Polymerase III Chain Elongation 18 1.72e-04 9.59e-04 0.59900 -5.67e-01 1.95e-01 3.13e-05 1.52e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 7 3.53e-03 1.43e-02 0.59900 3.29e-01 5.01e-01 1.32e-01 2.18e-02
Initial triggering of complement 79 1.05e-14 2.90e-13 0.59800 -4.82e-01 3.55e-01 1.25e-13 5.00e-08
Citric acid cycle (TCA cycle) 34 1.76e-09 2.25e-08 0.59800 -5.97e-01 2.25e-02 1.64e-09 8.20e-01
Translocation of ZAP-70 to Immunological synapse 24 1.25e-06 1.01e-05 0.59700 5.96e-02 -5.94e-01 6.13e-01 4.60e-07
tRNA modification in the mitochondrion 9 6.43e-03 2.33e-02 0.59700 -5.93e-01 6.58e-02 2.06e-03 7.32e-01
Negative regulation of NOTCH4 signaling 44 1.13e-10 1.75e-09 0.59600 -5.83e-01 1.24e-01 2.10e-11 1.56e-01
Biosynthesis of Lipoxins (LX) 6 2.99e-02 8.19e-02 0.59300 -2.14e-02 5.93e-01 9.28e-01 1.19e-02
Hh mutants abrogate ligand secretion 43 2.56e-09 3.18e-08 0.59300 -5.54e-01 2.11e-01 3.26e-10 1.67e-02
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 3.00e-02 8.20e-02 0.59200 -5.72e-01 -1.53e-01 2.67e-02 5.55e-01
PI3K events in ERBB4 signaling 6 7.13e-02 1.58e-01 0.59100 5.38e-01 -2.45e-01 2.24e-02 2.99e-01
Estrogen-stimulated signaling through PRKCZ 6 8.25e-02 1.77e-01 0.59100 -2.97e-01 5.11e-01 2.08e-01 3.02e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 60 3.77e-13 9.57e-12 0.58900 -5.64e-01 1.71e-01 4.16e-14 2.22e-02
Mitochondrial protein degradation 96 1.98e-22 7.97e-21 0.58900 -5.80e-01 1.01e-01 8.19e-23 8.65e-02
SLBP independent Processing of Histone Pre-mRNAs 10 1.84e-03 8.00e-03 0.58700 -5.83e-01 -6.26e-02 1.41e-03 7.32e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 9.02e-03 3.12e-02 0.58300 -3.30e-01 4.81e-01 4.80e-02 3.89e-03
Metabolism of polyamines 46 3.90e-10 5.66e-09 0.58300 -5.60e-01 1.64e-01 4.98e-11 5.50e-02
Deposition of new CENPA-containing nucleosomes at the centromere 38 1.83e-07 1.69e-06 0.58200 -5.10e-01 2.81e-01 5.28e-08 2.68e-03
Nucleosome assembly 38 1.83e-07 1.69e-06 0.58200 -5.10e-01 2.81e-01 5.28e-08 2.68e-03
LTC4-CYSLTR mediated IL4 production 5 4.58e-02 1.13e-01 0.58200 -5.73e-02 -5.79e-01 8.24e-01 2.49e-02
FCGR activation 76 3.92e-13 9.84e-12 0.58200 -4.18e-01 4.05e-01 2.97e-10 1.06e-09
APC/C:Cdc20 mediated degradation of mitotic proteins 63 4.00e-13 9.91e-12 0.58000 -5.50e-01 1.84e-01 4.17e-14 1.15e-02
APC/C:Cdc20 mediated degradation of Securin 55 3.35e-12 6.87e-11 0.57900 -5.63e-01 1.36e-01 5.03e-13 8.02e-02
rRNA modification in the nucleus and cytosol 59 7.99e-13 1.80e-11 0.57800 -5.59e-01 1.48e-01 1.05e-13 4.99e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 9.51e-03 3.24e-02 0.57800 -1.45e-01 -5.59e-01 5.05e-01 1.04e-02
Amyloid fiber formation 52 4.37e-09 5.09e-08 0.57700 -4.10e-01 4.06e-01 3.21e-07 3.94e-07
SCF(Skp2)-mediated degradation of p27/p21 50 1.70e-11 3.04e-10 0.57500 -5.66e-01 1.01e-01 4.18e-12 2.17e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 42 2.75e-09 3.36e-08 0.57500 -5.57e-01 1.42e-01 4.12e-10 1.10e-01
Mitophagy 38 3.35e-07 2.95e-06 0.57400 -4.97e-01 2.88e-01 1.16e-07 2.10e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 61 1.63e-12 3.45e-11 0.57400 -5.45e-01 1.80e-01 1.74e-13 1.48e-02
Autodegradation of the E3 ubiquitin ligase COP1 38 1.07e-08 1.21e-07 0.57400 -5.62e-01 1.18e-01 2.05e-09 2.09e-01
SCF-beta-TrCP mediated degradation of Emi1 42 1.64e-09 2.11e-08 0.57300 -5.61e-01 1.17e-01 3.13e-10 1.91e-01
Release of apoptotic factors from the mitochondria 6 2.61e-02 7.38e-02 0.57200 -5.67e-01 -7.35e-02 1.61e-02 7.55e-01
Removal of the Flap Intermediate 14 4.10e-05 2.68e-04 0.57200 -5.00e-01 -2.77e-01 1.19e-03 7.27e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 64 5.53e-13 1.30e-11 0.57000 -5.43e-01 1.76e-01 5.86e-14 1.47e-02
Defective LFNG causes SCDO3 5 1.03e-01 2.08e-01 0.57000 1.54e-01 -5.49e-01 5.50e-01 3.34e-02
STAT3 nuclear events downstream of ALK signaling 11 1.85e-02 5.49e-02 0.57000 3.84e-01 -4.21e-01 2.73e-02 1.55e-02
RHO GTPases activate PKNs 46 5.94e-08 5.97e-07 0.57000 -3.91e-01 4.15e-01 4.46e-06 1.11e-06
RHOT1 GTPase cycle 5 1.08e-01 2.16e-01 0.56800 -1.64e-01 5.44e-01 5.26e-01 3.51e-02
Regulation of Complement cascade 96 1.34e-15 3.92e-14 0.56700 -4.12e-01 3.89e-01 2.96e-12 4.42e-11
Influenza Infection 154 1.77e-38 1.01e-36 0.56300 -5.62e-01 -3.74e-02 1.71e-33 4.23e-01
Regulation of PTEN localization 9 3.83e-02 9.90e-02 0.56300 -4.56e-01 3.31e-01 1.78e-02 8.59e-02
Signaling by RNF43 mutants 7 1.52e-02 4.73e-02 0.56300 5.56e-01 8.77e-02 1.08e-02 6.88e-01
Defective pyroptosis 27 5.74e-06 4.25e-05 0.56300 -5.44e-01 1.44e-01 9.86e-07 1.94e-01
Formyl peptide receptors bind formyl peptides and many other ligands 7 8.17e-02 1.76e-01 0.56300 -4.42e-01 3.49e-01 4.29e-02 1.10e-01
Binding and Uptake of Ligands by Scavenger Receptors 94 3.78e-15 1.07e-13 0.56200 -4.27e-01 3.66e-01 8.39e-13 8.27e-10
Role of LAT2/NTAL/LAB on calcium mobilization 77 1.97e-12 4.14e-11 0.56100 -3.80e-01 4.12e-01 7.77e-09 3.96e-10
Processive synthesis on the lagging strand 15 2.42e-05 1.63e-04 0.56100 -4.65e-01 -3.14e-01 1.84e-03 3.52e-02
Zygotic genome activation (ZGA) 5 1.13e-01 2.24e-01 0.56000 5.38e-01 -1.55e-01 3.73e-02 5.50e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 4.15e-11 7.21e-10 0.55900 -5.20e-01 2.05e-01 4.99e-12 6.40e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.18e-02 3.89e-02 0.55700 -4.82e-01 2.80e-01 3.86e-03 9.27e-02
Complex IV assembly 45 8.12e-10 1.10e-08 0.55600 -5.48e-01 9.57e-02 1.97e-10 2.67e-01
Defective factor IX causes hemophilia B 6 1.18e-01 2.31e-01 0.55600 -3.15e-01 4.58e-01 1.82e-01 5.19e-02
Methionine salvage pathway 6 1.64e-02 5.04e-02 0.55600 -4.81e-01 -2.78e-01 4.13e-02 2.38e-01
Aerobic respiration and respiratory electron transport 245 1.38e-52 2.05e-50 0.55600 -5.53e-01 5.52e-02 1.79e-50 1.37e-01
Malate-aspartate shuttle 8 6.15e-03 2.25e-02 0.55500 -5.26e-01 -1.77e-01 9.95e-03 3.85e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 9.16e-02 1.90e-01 0.55300 3.69e-01 -4.12e-01 9.08e-02 5.92e-02
Abacavir ADME 5 6.92e-02 1.54e-01 0.55200 5.52e-01 2.11e-02 3.25e-02 9.35e-01
Autodegradation of Cdh1 by Cdh1:APC/C 54 4.51e-11 7.78e-10 0.55100 -5.38e-01 1.19e-01 7.88e-12 1.31e-01
Coenzyme A biosynthesis 7 1.08e-02 3.60e-02 0.55000 -2.21e-01 -5.03e-01 3.10e-01 2.12e-02
Cross-presentation of soluble exogenous antigens (endosomes) 35 3.33e-07 2.95e-06 0.54700 -5.31e-01 1.34e-01 5.50e-08 1.70e-01
PCNA-Dependent Long Patch Base Excision Repair 21 6.38e-07 5.43e-06 0.54600 -4.28e-01 -3.39e-01 6.91e-04 7.15e-03
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 6 1.81e-02 5.42e-02 0.54500 -4.54e-01 -3.02e-01 5.43e-02 2.00e-01
Formation of tubulin folding intermediates by CCT/TriC 21 6.46e-04 3.16e-03 0.54500 -4.65e-01 2.84e-01 2.24e-04 2.44e-02
Josephin domain DUBs 10 2.97e-02 8.18e-02 0.54500 -4.68e-01 2.78e-01 1.03e-02 1.28e-01
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 23 3.60e-04 1.87e-03 0.54300 -4.59e-01 2.89e-01 1.37e-04 1.64e-02
Pentose phosphate pathway 13 8.88e-03 3.07e-02 0.54300 -4.86e-01 2.40e-01 2.39e-03 1.33e-01
CDK-mediated phosphorylation and removal of Cdc6 60 8.94e-12 1.68e-10 0.54200 -5.28e-01 1.22e-01 1.44e-12 1.01e-01
Nectin/Necl trans heterodimerization 5 1.84e-01 3.11e-01 0.54200 4.47e-01 -3.05e-01 8.31e-02 2.37e-01
Noncanonical activation of NOTCH3 8 7.33e-02 1.61e-01 0.54200 -3.78e-01 3.88e-01 6.40e-02 5.75e-02
Synthesis of Dolichyl-phosphate 6 7.20e-02 1.59e-01 0.54100 -5.33e-01 9.68e-02 2.39e-02 6.81e-01
APOBEC3G mediated resistance to HIV-1 infection 5 3.50e-02 9.26e-02 0.54100 -3.59e-01 -4.05e-01 1.65e-01 1.17e-01
Phenylalanine metabolism 5 5.11e-02 1.23e-01 0.54000 -1.59e-01 -5.17e-01 5.39e-01 4.54e-02
Bicarbonate transporters 9 4.05e-02 1.03e-01 0.54000 4.80e-01 -2.48e-01 1.27e-02 1.98e-01
RNA Polymerase III Transcription Termination 23 1.16e-04 6.74e-04 0.53800 -5.12e-01 1.62e-01 2.09e-05 1.78e-01
Synthesis of diphthamide-EEF2 8 3.19e-02 8.64e-02 0.53700 -5.28e-01 9.80e-02 9.69e-03 6.31e-01
Adenylate cyclase activating pathway 8 4.37e-02 1.08e-01 0.53400 5.10e-01 -1.58e-01 1.24e-02 4.38e-01
Signal attenuation 9 3.83e-02 9.90e-02 0.53300 -2.10e-01 4.90e-01 2.74e-01 1.10e-02
Signaling by ROBO receptors 189 5.84e-38 3.22e-36 0.53300 -5.31e-01 4.47e-02 1.92e-36 2.89e-01
Miscellaneous substrates 7 6.74e-02 1.51e-01 0.53100 5.07e-01 -1.59e-01 2.03e-02 4.67e-01
Stabilization of p53 43 2.00e-08 2.16e-07 0.53000 -5.19e-01 1.09e-01 3.81e-09 2.15e-01
Degradation of GLI2 by the proteasome 45 2.38e-08 2.54e-07 0.53000 -5.09e-01 1.47e-01 3.33e-09 8.69e-02
Alpha-oxidation of phytanate 6 3.47e-02 9.22e-02 0.53000 -5.13e-01 -1.33e-01 2.94e-02 5.73e-01
Protein methylation 15 1.77e-03 7.73e-03 0.53000 -5.22e-01 9.00e-02 4.65e-04 5.46e-01
Regulation of APC/C activators between G1/S and early anaphase 68 1.42e-12 3.04e-11 0.53000 -5.15e-01 1.25e-01 2.10e-13 7.37e-02
Degradation of DVL 43 6.49e-08 6.50e-07 0.52900 -5.06e-01 1.54e-01 9.08e-09 8.14e-02
Condensation of Prophase Chromosomes 27 1.48e-04 8.38e-04 0.52900 -4.47e-01 2.83e-01 5.90e-05 1.09e-02
Orc1 removal from chromatin 58 3.85e-11 6.77e-10 0.52800 -5.18e-01 1.00e-01 8.29e-12 1.88e-01
Regulation of CDH11 function 10 2.74e-02 7.65e-02 0.52800 4.89e-01 -2.00e-01 7.42e-03 2.75e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 16 5.28e-03 2.00e-02 0.52800 -4.50e-01 2.75e-01 1.83e-03 5.65e-02
Complement cascade 100 3.28e-14 8.93e-13 0.52700 -3.99e-01 3.45e-01 5.52e-12 2.34e-09
Lipophagy 7 1.15e-01 2.27e-01 0.52700 -3.65e-01 3.79e-01 9.41e-02 8.22e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 2.69e-02 7.54e-02 0.52700 3.33e-02 -5.26e-01 8.71e-01 1.00e-02
Calcitonin-like ligand receptors 5 9.77e-02 2.00e-01 0.52600 5.26e-01 -1.01e-02 4.18e-02 9.69e-01
Reactions specific to the complex N-glycan synthesis pathway 7 1.05e-01 2.12e-01 0.52500 -4.43e-01 2.82e-01 4.26e-02 1.96e-01
Alternative complement activation 5 4.26e-02 1.06e-01 0.52500 -3.50e-01 -3.91e-01 1.75e-01 1.30e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.48e-07 1.39e-06 0.52400 -3.85e-01 -3.55e-01 8.73e-04 2.09e-03
Assembly of the pre-replicative complex 87 3.44e-15 9.91e-14 0.52400 -5.04e-01 1.40e-01 3.97e-16 2.38e-02
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 6 2.46e-02 7.02e-02 0.52300 2.97e-01 4.30e-01 2.08e-01 6.79e-02
Post-chaperonin tubulin folding pathway 18 4.15e-03 1.63e-02 0.52100 -3.98e-01 3.37e-01 3.47e-03 1.33e-02
APC/C:Cdc20 mediated degradation of Cyclin B 24 9.45e-05 5.57e-04 0.52100 -5.05e-01 1.28e-01 1.83e-05 2.76e-01
Regulation of RUNX3 expression and activity 45 4.74e-08 4.90e-07 0.52000 -4.99e-01 1.45e-01 6.74e-09 9.25e-02
Inactivation of CDC42 and RAC1 7 1.20e-01 2.34e-01 0.51900 -3.29e-01 4.01e-01 1.31e-01 6.61e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 3.64e-04 1.88e-03 0.51900 -4.84e-01 -1.86e-01 1.70e-03 2.28e-01
Interleukin-18 signaling 6 2.78e-02 7.73e-02 0.51800 4.46e-01 2.64e-01 5.85e-02 2.63e-01
Interleukin-9 signaling 8 8.40e-02 1.79e-01 0.51800 4.28e-01 -2.91e-01 3.59e-02 1.54e-01
Estrogen biosynthesis 5 6.18e-02 1.42e-01 0.51800 1.73e-01 4.88e-01 5.02e-01 5.90e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 61 5.24e-11 8.96e-10 0.51700 -5.05e-01 1.13e-01 9.01e-12 1.28e-01
Purine ribonucleoside monophosphate biosynthesis 9 1.01e-02 3.41e-02 0.51700 -5.09e-01 -9.08e-02 8.20e-03 6.37e-01
RORA activates gene expression 18 8.78e-04 4.17e-03 0.51600 5.05e-01 -1.05e-01 2.06e-04 4.41e-01
Miro GTPase Cycle 8 7.75e-02 1.68e-01 0.51500 -2.47e-01 4.52e-01 2.27e-01 2.70e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 2.39e-04 1.29e-03 0.51400 -4.28e-01 -2.86e-01 5.60e-03 6.41e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 5.39e-05 3.39e-04 0.51400 -4.84e-01 1.74e-01 9.29e-06 1.11e-01
Leading Strand Synthesis 14 2.10e-04 1.15e-03 0.51400 -3.32e-01 -3.93e-01 3.17e-02 1.09e-02
Polymerase switching 14 2.10e-04 1.15e-03 0.51400 -3.32e-01 -3.93e-01 3.17e-02 1.09e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 6.44e-07 5.46e-06 0.51200 -4.59e-01 -2.27e-01 7.00e-05 4.99e-02
G1/S DNA Damage Checkpoints 54 1.02e-09 1.35e-08 0.51200 -5.01e-01 1.06e-01 1.90e-10 1.78e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 5.00e-03 1.91e-02 0.51200 3.26e-01 -3.95e-01 1.67e-02 3.73e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5 2.07e-01 3.38e-01 0.51100 4.48e-01 -2.45e-01 8.25e-02 3.42e-01
PD-1 signaling 28 1.36e-05 9.42e-05 0.51000 7.21e-02 -5.05e-01 5.09e-01 3.73e-06
GLI3 is processed to GLI3R by the proteasome 46 5.37e-08 5.52e-07 0.51000 -4.92e-01 1.36e-01 7.92e-09 1.10e-01
Regulation of CDH19 Expression and Function 6 1.72e-01 2.97e-01 0.51000 3.97e-01 -3.21e-01 9.25e-02 1.74e-01
Neurotransmitter clearance 6 1.44e-01 2.63e-01 0.51000 -2.21e-01 4.59e-01 3.48e-01 5.15e-02
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 4.30e-02 1.07e-01 0.50900 -4.49e-01 2.40e-01 1.39e-02 1.88e-01
Diseases of hemostasis 15 9.29e-03 3.18e-02 0.50900 -2.48e-01 4.45e-01 9.69e-02 2.83e-03
Meiotic recombination 37 6.11e-06 4.51e-05 0.50900 -4.62e-01 2.15e-01 1.16e-06 2.38e-02
VLDLR internalisation and degradation 16 4.94e-03 1.89e-02 0.50800 -4.69e-01 1.95e-01 1.15e-03 1.76e-01
Displacement of DNA glycosylase by APEX1 9 9.50e-03 3.24e-02 0.50800 -4.90e-01 -1.34e-01 1.10e-02 4.85e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 52 8.13e-09 9.30e-08 0.50800 -4.88e-01 1.40e-01 1.12e-09 8.12e-02
Acetylcholine Neurotransmitter Release Cycle 11 1.66e-02 5.06e-02 0.50800 1.14e-01 -4.95e-01 5.13e-01 4.49e-03
PRC2 methylates histones and DNA 27 1.11e-04 6.46e-04 0.50800 -4.74e-01 1.81e-01 2.00e-05 1.03e-01
DNA Replication Pre-Initiation 103 9.25e-17 3.08e-15 0.50500 -4.88e-01 1.32e-01 1.09e-17 2.09e-02
PTK6 Regulates Cell Cycle 6 2.99e-02 8.19e-02 0.50500 -3.38e-01 -3.76e-01 1.52e-01 1.11e-01
Phosphorylation of CD3 and TCR zeta chains 27 2.57e-05 1.73e-04 0.50500 7.19e-02 -4.99e-01 5.18e-01 7.01e-06
Maturation of hRSV A proteins 13 2.55e-02 7.23e-02 0.50400 -3.50e-01 3.62e-01 2.87e-02 2.39e-02
Degradation of AXIN 42 2.19e-07 1.99e-06 0.50300 -4.90e-01 1.15e-01 3.84e-08 1.98e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 2.76e-02 7.69e-02 0.50300 4.66e-01 -1.90e-01 7.49e-03 2.75e-01
TNFR1-mediated ceramide production 6 3.27e-02 8.82e-02 0.50300 -2.83e-01 -4.15e-01 2.30e-01 7.80e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 8.25e-05 4.95e-04 0.50100 -5.00e-01 3.33e-02 3.26e-05 7.82e-01
MET activates RAP1 and RAC1 10 6.72e-03 2.42e-02 0.50100 1.26e-01 4.85e-01 4.91e-01 7.91e-03
Degradation of GLI1 by the proteasome 46 1.88e-07 1.73e-06 0.50100 -4.74e-01 1.61e-01 2.62e-08 5.89e-02
B-WICH complex positively regulates rRNA expression 45 1.88e-06 1.49e-05 0.50000 -4.24e-01 2.66e-01 8.65e-07 2.04e-03
FCERI mediated NF-kB activation 129 1.23e-16 4.02e-15 0.50000 -4.04e-01 2.95e-01 2.29e-15 7.40e-09
p53-Dependent G1 DNA Damage Response 52 4.11e-09 4.81e-08 0.49900 -4.91e-01 9.06e-02 9.17e-10 2.59e-01
p53-Dependent G1/S DNA damage checkpoint 52 4.11e-09 4.81e-08 0.49900 -4.91e-01 9.06e-02 9.17e-10 2.59e-01
Protein hydroxylation 17 2.06e-03 8.88e-03 0.49900 -4.88e-01 1.04e-01 4.97e-04 4.57e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 4.08e-10 5.84e-09 0.49800 -4.55e-01 2.02e-01 6.14e-11 3.63e-03
Presynaptic depolarization and calcium channel opening 8 1.08e-01 2.17e-01 0.49800 3.78e-01 -3.24e-01 6.40e-02 1.13e-01
Physiological factors 9 6.13e-03 2.25e-02 0.49700 3.76e-01 3.26e-01 5.10e-02 9.08e-02
Ketone body metabolism 8 5.85e-02 1.36e-01 0.49700 -4.83e-01 1.16e-01 1.79e-02 5.69e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 9 6.79e-03 2.44e-02 0.49700 2.72e-01 4.16e-01 1.57e-01 3.08e-02
Platelet Adhesion to exposed collagen 16 7.73e-03 2.72e-02 0.49700 -2.22e-01 4.45e-01 1.25e-01 2.08e-03
Carnitine shuttle 12 1.40e-02 4.44e-02 0.49300 1.02e-01 -4.82e-01 5.40e-01 3.82e-03
ABC transporter disorders 60 8.78e-09 9.98e-08 0.49300 -4.53e-01 1.95e-01 1.30e-09 9.12e-03
RUNX1 regulates expression of components of tight junctions 5 9.06e-02 1.89e-01 0.49300 1.18e-01 4.78e-01 6.48e-01 6.40e-02
Lagging Strand Synthesis 20 1.54e-05 1.05e-04 0.49300 -3.81e-01 -3.12e-01 3.16e-03 1.57e-02
APC/C-mediated degradation of cell cycle proteins 75 8.55e-12 1.62e-10 0.49200 -4.75e-01 1.29e-01 1.10e-12 5.25e-02
Regulation of mitotic cell cycle 75 8.55e-12 1.62e-10 0.49200 -4.75e-01 1.29e-01 1.10e-12 5.25e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 9 8.61e-02 1.82e-01 0.49100 -3.85e-01 3.04e-01 4.52e-02 1.14e-01
Sperm Motility And Taxes 6 4.92e-02 1.19e-01 0.49000 -1.71e-01 -4.59e-01 4.68e-01 5.16e-02
Disorders of Developmental Biology 12 4.07e-02 1.03e-01 0.48900 3.24e-01 -3.66e-01 5.22e-02 2.81e-02
Disorders of Nervous System Development 12 4.07e-02 1.03e-01 0.48900 3.24e-01 -3.66e-01 5.22e-02 2.81e-02
Loss of function of MECP2 in Rett syndrome 12 4.07e-02 1.03e-01 0.48900 3.24e-01 -3.66e-01 5.22e-02 2.81e-02
Pervasive developmental disorders 12 4.07e-02 1.03e-01 0.48900 3.24e-01 -3.66e-01 5.22e-02 2.81e-02
Androgen biosynthesis 5 1.16e-01 2.28e-01 0.48900 -4.87e-01 -4.18e-02 5.94e-02 8.71e-01
GDP-fucose biosynthesis 6 6.38e-02 1.45e-01 0.48800 -4.79e-01 -9.34e-02 4.22e-02 6.92e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 1.56e-01 2.78e-01 0.48700 3.18e-01 -3.69e-01 1.45e-01 9.08e-02
MASTL Facilitates Mitotic Progression 10 6.65e-02 1.50e-01 0.48700 -3.95e-01 2.85e-01 3.07e-02 1.18e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.93e-04 1.54e-03 0.48600 -4.82e-01 5.68e-02 8.92e-05 6.45e-01
rRNA modification in the mitochondrion 8 4.06e-02 1.03e-01 0.48600 -4.86e-01 2.63e-03 1.74e-02 9.90e-01
NIK–>noncanonical NF-kB signaling 46 5.90e-08 5.97e-07 0.48500 -4.80e-01 6.84e-02 1.73e-08 4.22e-01
Mismatch Repair 15 4.62e-04 2.33e-03 0.48500 -4.34e-01 -2.16e-01 3.57e-03 1.48e-01
Regulation of MITF-M-dependent genes involved in apoptosis 16 1.41e-02 4.46e-02 0.48500 3.83e-01 -2.98e-01 7.98e-03 3.93e-02
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 1.13e-01 2.24e-01 0.48500 -4.04e-01 2.67e-01 4.76e-02 1.90e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.15e-04 1.17e-03 0.48400 -4.71e-01 1.09e-01 4.53e-05 3.48e-01
Synthesis of Ketone Bodies 6 1.08e-01 2.17e-01 0.48300 -4.81e-01 4.90e-02 4.14e-02 8.35e-01
Cytosolic tRNA aminoacylation 24 7.05e-05 4.28e-04 0.48200 -4.82e-01 -2.86e-03 4.27e-05 9.81e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 1.97e-01 3.26e-01 0.48200 1.31e-01 -4.64e-01 6.13e-01 7.21e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 4.99e-10 6.94e-09 0.48200 -3.24e-01 3.56e-01 3.22e-07 2.06e-08
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.25e-04 7.20e-04 0.48100 -4.62e-01 1.35e-01 2.31e-05 2.15e-01
Switching of origins to a post-replicative state 79 6.70e-13 1.54e-11 0.48100 -4.76e-01 7.01e-02 2.43e-13 2.82e-01
APC-Cdc20 mediated degradation of Nek2A 26 3.16e-04 1.65e-03 0.48100 -4.55e-01 1.57e-01 5.94e-05 1.65e-01
Interleukin-15 signaling 14 1.82e-02 5.44e-02 0.47900 4.33e-01 -2.04e-01 5.01e-03 1.87e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 2.19e-02 6.37e-02 0.47800 -1.84e-01 4.42e-01 2.50e-01 5.83e-03
Protein localization 157 2.68e-27 1.29e-25 0.47800 -4.78e-01 -2.31e-03 3.96e-25 9.60e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 1.64e-02 5.04e-02 0.47800 -3.72e-01 2.99e-01 1.00e-02 3.81e-02
Interconversion of nucleotide di- and triphosphates 27 4.83e-05 3.11e-04 0.47700 -4.76e-01 3.48e-02 1.87e-05 7.54e-01
VEGF binds to VEGFR leading to receptor dimerization 5 2.50e-01 3.89e-01 0.47600 -4.24e-01 2.17e-01 1.01e-01 4.01e-01
VEGF ligand-receptor interactions 5 2.50e-01 3.89e-01 0.47600 -4.24e-01 2.17e-01 1.01e-01 4.01e-01
Glycogen synthesis 11 6.30e-02 1.44e-01 0.47500 -3.49e-01 3.21e-01 4.48e-02 6.49e-02
Resolution of Abasic Sites (AP sites) 38 3.07e-09 3.72e-08 0.47500 -3.58e-01 -3.11e-01 1.32e-04 8.93e-04
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 1.39e-02 4.43e-02 0.47400 -4.10e-01 2.38e-01 4.54e-03 9.91e-02
NFE2L2 regulates pentose phosphate pathway genes 8 1.81e-02 5.42e-02 0.47400 2.51e-01 4.02e-01 2.20e-01 4.90e-02
ROBO receptors bind AKAP5 7 1.50e-01 2.70e-01 0.47300 2.25e-01 -4.16e-01 3.03e-01 5.65e-02
Platelet degranulation 106 3.55e-12 7.14e-11 0.47100 -3.65e-01 2.98e-01 8.22e-11 1.19e-07
GP1b-IX-V activation signalling 12 4.92e-02 1.19e-01 0.47100 -2.87e-01 3.73e-01 8.51e-02 2.52e-02
Defective HLCS causes multiple carboxylase deficiency 7 2.86e-02 7.93e-02 0.47000 -3.38e-01 -3.27e-01 1.22e-01 1.34e-01
Base Excision Repair 57 6.07e-11 1.02e-09 0.47000 -4.65e-01 -6.73e-02 1.25e-09 3.79e-01
Telomere Extension By Telomerase 23 1.72e-03 7.56e-03 0.47000 -4.27e-01 1.97e-01 3.97e-04 1.03e-01
Removal of the Flap Intermediate from the C-strand 17 2.34e-04 1.27e-03 0.46800 -3.92e-01 -2.56e-01 5.13e-03 6.81e-02
Activation of SMO 13 3.54e-02 9.35e-02 0.46800 3.97e-01 -2.47e-01 1.31e-02 1.22e-01
Translesion synthesis by REV1 16 9.87e-04 4.65e-03 0.46800 -4.54e-01 -1.12e-01 1.66e-03 4.40e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 3.26e-03 1.33e-02 0.46800 -4.50e-01 -1.28e-01 4.98e-03 4.26e-01
DNA Replication 128 2.84e-19 1.05e-17 0.46700 -4.62e-01 6.76e-02 1.61e-19 1.87e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 1.66e-01 2.89e-01 0.46600 -2.09e-02 4.66e-01 9.35e-01 7.12e-02
Glycerophospholipid catabolism 6 1.80e-01 3.05e-01 0.46600 1.63e-01 -4.37e-01 4.90e-01 6.40e-02
RUNX1 regulates transcription of genes involved in WNT signaling 5 9.92e-02 2.02e-01 0.46400 4.25e-01 1.87e-01 9.98e-02 4.68e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 1.97e-02 5.81e-02 0.46400 3.73e-01 -2.76e-01 9.77e-03 5.57e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 1.21e-01 2.34e-01 0.46400 -2.58e-02 4.63e-01 9.13e-01 4.95e-02
Cohesin Loading onto Chromatin 10 3.77e-02 9.82e-02 0.46400 4.58e-01 -7.16e-02 1.21e-02 6.95e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 5.18e-02 1.24e-01 0.46400 -2.67e-01 3.79e-01 1.10e-01 2.29e-02
Transport of connexons to the plasma membrane 12 5.18e-02 1.24e-01 0.46400 -2.67e-01 3.79e-01 1.10e-01 2.29e-02
Translesion synthesis by POLI 17 8.13e-04 3.90e-03 0.46300 -4.53e-01 -9.83e-02 1.23e-03 4.83e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 1.49e-07 1.40e-06 0.46200 -4.41e-01 -1.39e-01 4.63e-06 1.49e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 6.24e-03 2.28e-02 0.46200 -4.18e-01 -1.97e-01 1.63e-02 2.59e-01
Digestion 5 1.69e-01 2.94e-01 0.46200 -1.48e-02 4.61e-01 9.54e-01 7.41e-02
Telomere Maintenance 78 1.12e-11 2.06e-10 0.46100 -4.56e-01 7.22e-02 3.36e-12 2.71e-01
RNA Polymerase I Transcription Termination 30 4.67e-05 3.03e-04 0.46100 -4.58e-01 5.53e-02 1.42e-05 6.00e-01
Intrinsic Pathway of Fibrin Clot Formation 15 2.79e-02 7.75e-02 0.46100 -3.58e-01 2.90e-01 1.65e-02 5.17e-02
Regulation of RUNX1 Expression and Activity 18 9.25e-03 3.17e-02 0.46000 4.11e-01 -2.07e-01 2.54e-03 1.28e-01
Insulin receptor recycling 24 3.47e-03 1.41e-02 0.46000 -3.08e-01 3.42e-01 9.09e-03 3.74e-03
Sodium/Proton exchangers 7 1.74e-01 2.99e-01 0.46000 3.94e-01 -2.36e-01 7.08e-02 2.79e-01
Branched-chain ketoacid dehydrogenase kinase deficiency 5 3.08e-01 4.49e-01 0.45900 -3.04e-01 3.44e-01 2.39e-01 1.83e-01
Fructose metabolism 7 3.77e-02 9.82e-02 0.45900 -2.32e-01 -3.97e-01 2.89e-01 6.92e-02
LGI-ADAM interactions 9 1.13e-01 2.24e-01 0.45900 2.60e-01 -3.78e-01 1.78e-01 4.96e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 3.11e-04 1.63e-03 0.45800 -4.44e-01 1.10e-01 6.43e-05 3.23e-01
Response to elevated platelet cytosolic Ca2+ 110 5.37e-12 1.05e-10 0.45800 -3.60e-01 2.82e-01 6.38e-11 3.22e-07
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 7 1.86e-01 3.13e-01 0.45600 2.53e-01 -3.79e-01 2.47e-01 8.23e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 1.38e-02 4.42e-02 0.45500 -4.29e-01 -1.50e-01 1.88e-02 4.12e-01
Adherens junctions interactions 41 5.26e-05 3.34e-04 0.45400 3.81e-01 -2.47e-01 2.37e-05 6.17e-03
Synthesis of DNA 108 3.44e-17 1.17e-15 0.45400 -4.54e-01 -1.16e-03 3.40e-16 9.83e-01
FCGR3A-mediated phagocytosis 121 9.76e-13 2.12e-11 0.45400 -3.12e-01 3.30e-01 3.02e-09 3.73e-10
Leishmania phagocytosis 121 9.76e-13 2.12e-11 0.45400 -3.12e-01 3.30e-01 3.02e-09 3.73e-10
Parasite infection 121 9.76e-13 2.12e-11 0.45400 -3.12e-01 3.30e-01 3.02e-09 3.73e-10
Digestion and absorption 7 1.57e-01 2.80e-01 0.45400 -1.75e-01 4.19e-01 4.24e-01 5.51e-02
Mitochondrial tRNA aminoacylation 21 1.68e-04 9.40e-04 0.45300 -4.36e-01 -1.23e-01 5.34e-04 3.30e-01
Synthesis of PIPs at the ER membrane 5 3.12e-01 4.53e-01 0.45300 3.60e-01 -2.75e-01 1.63e-01 2.87e-01
RUNX1 regulates estrogen receptor mediated transcription 6 1.87e-01 3.14e-01 0.45200 4.32e-01 -1.34e-01 6.71e-02 5.69e-01
Dectin-1 mediated noncanonical NF-kB signaling 48 2.13e-07 1.95e-06 0.45200 -4.49e-01 5.28e-02 7.30e-08 5.27e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 4.94e-04 2.47e-03 0.45200 2.76e-01 -3.57e-01 6.01e-03 3.82e-04
Activation of NOXA and translocation to mitochondria 5 3.09e-01 4.50e-01 0.45100 2.56e-01 -3.72e-01 3.22e-01 1.50e-01
Metabolism of folate and pterines 16 5.66e-03 2.12e-02 0.45000 -4.48e-01 4.23e-02 1.89e-03 7.70e-01
Type I hemidesmosome assembly 8 1.60e-01 2.82e-01 0.45000 3.52e-01 -2.81e-01 8.44e-02 1.69e-01
RHOT2 GTPase cycle 7 1.80e-01 3.05e-01 0.45000 -2.13e-01 3.96e-01 3.28e-01 6.98e-02
Somitogenesis 41 6.64e-06 4.86e-05 0.44900 -4.37e-01 1.03e-01 1.24e-06 2.56e-01
Platelet Aggregation (Plug Formation) 30 9.97e-04 4.69e-03 0.44900 -2.61e-01 3.65e-01 1.33e-02 5.39e-04
Regulation of RAS by GAPs 55 6.73e-07 5.68e-06 0.44900 -4.14e-01 1.72e-01 1.05e-07 2.71e-02
Defects in biotin (Btn) metabolism 8 2.70e-02 7.58e-02 0.44900 -2.43e-01 -3.77e-01 2.34e-01 6.47e-02
Asymmetric localization of PCP proteins 49 1.58e-06 1.25e-05 0.44800 -4.27e-01 1.38e-01 2.37e-07 9.54e-02
Role of phospholipids in phagocytosis 88 3.08e-09 3.72e-08 0.44800 -3.19e-01 3.14e-01 2.27e-07 3.43e-07
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.52e-03 1.06e-02 0.44700 -4.34e-01 1.09e-01 5.80e-04 3.87e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.52e-03 1.06e-02 0.44700 -4.34e-01 1.09e-01 5.80e-04 3.87e-01
Creatine metabolism 6 1.61e-01 2.83e-01 0.44600 6.72e-02 -4.41e-01 7.75e-01 6.13e-02
tRNA Aminoacylation 42 1.55e-07 1.45e-06 0.44600 -4.41e-01 -6.61e-02 7.51e-07 4.58e-01
Condensation of Prometaphase Chromosomes 11 8.56e-02 1.81e-01 0.44600 -3.45e-01 2.82e-01 4.73e-02 1.06e-01
Interleukin receptor SHC signaling 23 2.14e-03 9.17e-03 0.44400 4.22e-01 -1.38e-01 4.55e-04 2.51e-01
Interleukin-20 family signaling 17 1.96e-02 5.78e-02 0.44400 3.76e-01 -2.36e-01 7.21e-03 9.20e-02
p75NTR recruits signalling complexes 12 3.81e-02 9.89e-02 0.44400 -4.26e-01 1.27e-01 1.07e-02 4.45e-01
Interleukin-6 signaling 11 4.52e-02 1.11e-01 0.44400 4.31e-01 -1.07e-01 1.33e-02 5.38e-01
Signaling by FLT3 fusion proteins 18 1.28e-02 4.12e-02 0.44400 3.96e-01 -2.00e-01 3.59e-03 1.42e-01
Fatty acids 6 1.98e-01 3.28e-01 0.44400 4.24e-01 -1.31e-01 7.23e-02 5.79e-01
Signaling by ALK 24 4.64e-03 1.79e-02 0.44300 3.57e-01 -2.64e-01 2.49e-03 2.53e-02
Regulation of RUNX2 expression and activity 54 1.98e-07 1.81e-06 0.44300 -4.33e-01 9.49e-02 3.69e-08 2.28e-01
DNA replication initiation 8 5.13e-02 1.23e-01 0.44300 -4.37e-01 -7.21e-02 3.24e-02 7.24e-01
Translesion synthesis by POLK 17 1.45e-03 6.56e-03 0.44300 -4.31e-01 -9.91e-02 2.07e-03 4.79e-01
FCERI mediated MAPK activation 93 1.89e-09 2.40e-08 0.44100 -3.15e-01 3.08e-01 1.44e-07 2.73e-07
Regulation of PTEN stability and activity 55 9.81e-07 8.07e-06 0.44100 -4.09e-01 1.64e-01 1.51e-07 3.53e-02
Dual Incision in GG-NER 41 1.09e-07 1.05e-06 0.44100 -4.24e-01 -1.21e-01 2.66e-06 1.81e-01
Budding and maturation of HIV virion 26 9.27e-04 4.38e-03 0.44000 -4.23e-01 1.23e-01 1.91e-04 2.76e-01
Anchoring fibril formation 10 1.46e-02 4.59e-02 0.44000 1.99e-01 3.92e-01 2.75e-01 3.17e-02
Ubiquinol biosynthesis 13 1.72e-02 5.21e-02 0.44000 -4.38e-01 3.22e-02 6.20e-03 8.41e-01
mRNA Splicing - Minor Pathway 50 5.49e-08 5.61e-07 0.43900 -4.39e-01 -1.08e-02 7.63e-08 8.95e-01
Regulation of MECP2 expression and activity 29 1.79e-03 7.81e-03 0.43900 3.47e-01 -2.70e-01 1.23e-03 1.20e-02
Interleukin-2 signaling 11 6.62e-02 1.49e-01 0.43900 4.04e-01 -1.71e-01 2.02e-02 3.26e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 7.44e-02 1.63e-01 0.43900 -2.77e-01 3.40e-01 9.70e-02 4.12e-02
Sema4D mediated inhibition of cell attachment and migration 7 1.99e-01 3.28e-01 0.43800 -3.83e-01 2.14e-01 7.95e-02 3.27e-01
Activated NTRK3 signals through PI3K 5 1.60e-01 2.82e-01 0.43800 4.32e-01 7.62e-02 9.47e-02 7.68e-01
Formation of the Early Elongation Complex 33 2.29e-05 1.55e-04 0.43800 -4.38e-01 5.92e-03 1.33e-05 9.53e-01
Formation of the HIV-1 Early Elongation Complex 33 2.29e-05 1.55e-04 0.43800 -4.38e-01 5.92e-03 1.33e-05 9.53e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 1.22e-01 2.36e-01 0.43600 -4.33e-01 -5.08e-02 6.61e-02 8.29e-01
Vitamin B1 (thiamin) metabolism 5 2.83e-01 4.25e-01 0.43600 -4.10e-01 1.48e-01 1.12e-01 5.68e-01
Recognition of DNA damage by PCNA-containing replication complex 30 1.46e-05 1.01e-04 0.43600 -4.25e-01 -9.50e-02 5.54e-05 3.68e-01
FCERI mediated Ca+2 mobilization 92 3.90e-09 4.62e-08 0.43500 -3.02e-01 3.14e-01 5.46e-07 2.00e-07
MECP2 regulates transcription factors 5 2.62e-01 4.05e-01 0.43500 4.21e-01 -1.11e-01 1.03e-01 6.68e-01
FLT3 signaling by CBL mutants 7 1.31e-01 2.48e-01 0.43500 -4.30e-01 6.42e-02 4.87e-02 7.69e-01
Metabolism of cofactors 25 2.33e-04 1.26e-03 0.43500 -4.34e-01 -2.40e-02 1.70e-04 8.36e-01
Metabolism of amino acids and derivatives 308 8.01e-43 6.45e-41 0.43400 -4.34e-01 6.86e-03 2.36e-39 8.36e-01
Interleukin-7 signaling 21 1.70e-03 7.49e-03 0.43400 4.33e-01 -3.34e-02 5.97e-04 7.91e-01
Negative feedback regulation of MAPK pathway 6 2.81e-01 4.23e-01 0.43300 -2.71e-01 3.38e-01 2.50e-01 1.52e-01
Pexophagy 10 1.92e-02 5.67e-02 0.43300 -4.03e-01 -1.59e-01 2.74e-02 3.84e-01
Advanced glycosylation endproduct receptor signaling 12 8.07e-02 1.74e-01 0.43300 -3.26e-01 2.85e-01 5.03e-02 8.76e-02
Ras activation upon Ca2+ influx through NMDA receptor 18 2.05e-02 6.02e-02 0.43300 3.58e-01 -2.43e-01 8.63e-03 7.38e-02
Prevention of phagosomal-lysosomal fusion 9 1.29e-01 2.44e-01 0.43100 -3.84e-01 1.97e-01 4.61e-02 3.07e-01
Processive synthesis on the C-strand of the telomere 19 3.81e-04 1.96e-03 0.43100 -3.68e-01 -2.24e-01 5.45e-03 9.08e-02
MET receptor recycling 9 3.40e-02 9.13e-02 0.43100 1.21e-01 4.13e-01 5.29e-01 3.17e-02
Erythrocytes take up oxygen and release carbon dioxide 7 6.27e-02 1.43e-01 0.43000 3.94e-01 1.72e-01 7.10e-02 4.30e-01
Acetylcholine regulates insulin secretion 9 1.29e-01 2.45e-01 0.43000 1.93e-01 -3.84e-01 3.16e-01 4.59e-02
Interleukin-6 family signaling 20 1.20e-02 3.93e-02 0.42900 3.74e-01 -2.11e-01 3.77e-03 1.03e-01
Activation of BAD and translocation to mitochondria 15 4.60e-02 1.13e-01 0.42900 -3.17e-01 2.89e-01 3.33e-02 5.29e-02
Cellular response to hypoxia 59 3.19e-07 2.84e-06 0.42900 -4.11e-01 1.22e-01 4.72e-08 1.05e-01
Prostanoid ligand receptors 8 1.95e-01 3.23e-01 0.42900 -2.98e-01 3.08e-01 1.45e-01 1.31e-01
Chromosome Maintenance 103 5.80e-13 1.35e-11 0.42800 -4.21e-01 7.71e-02 1.42e-13 1.77e-01
Spry regulation of FGF signaling 16 3.82e-02 9.89e-02 0.42800 -2.99e-01 3.07e-01 3.87e-02 3.35e-02
Nucleotide biosynthesis 12 7.02e-03 2.50e-02 0.42800 -3.54e-01 -2.41e-01 3.38e-02 1.48e-01
Termination of translesion DNA synthesis 32 7.69e-06 5.59e-05 0.42700 -4.10e-01 -1.20e-01 6.07e-05 2.42e-01
Synthesis of GDP-mannose 6 2.70e-01 4.13e-01 0.42700 -3.72e-01 2.08e-01 1.14e-01 3.77e-01
Molybdenum cofactor biosynthesis 6 1.09e-01 2.18e-01 0.42600 -1.25e-01 -4.07e-01 5.95e-01 8.45e-02
Neurotoxicity of clostridium toxins 9 1.14e-01 2.25e-01 0.42400 1.37e-01 -4.01e-01 4.77e-01 3.71e-02
Receptor Mediated Mitophagy 11 9.73e-02 1.99e-01 0.42400 -3.62e-01 2.21e-01 3.77e-02 2.05e-01
Glutathione conjugation 28 8.10e-05 4.87e-04 0.42400 -4.19e-01 -6.23e-02 1.24e-04 5.69e-01
Selective autophagy 77 9.96e-08 9.77e-07 0.42300 -3.59e-01 2.24e-01 5.19e-08 6.73e-04
Defective GALNT3 causes HFTC 9 1.04e-01 2.11e-01 0.42200 4.08e-01 -1.10e-01 3.42e-02 5.68e-01
Proton-coupled monocarboxylate transport 6 1.94e-01 3.23e-01 0.42200 -6.15e-02 4.18e-01 7.94e-01 7.65e-02
Uptake of dietary cobalamins into enterocytes 6 2.42e-01 3.81e-01 0.42200 1.42e-01 -3.97e-01 5.47e-01 9.21e-02
Metabolism of RNA 718 3.09e-90 2.99e-87 0.42200 -4.21e-01 1.86e-02 4.28e-83 3.96e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 7.09e-03 2.52e-02 0.42000 -3.54e-01 2.26e-01 2.66e-03 5.50e-02
Phosphorylation of the APC/C 20 4.27e-03 1.67e-02 0.42000 -4.16e-01 5.54e-02 1.28e-03 6.68e-01
tRNA modification in the nucleus and cytosol 43 2.95e-07 2.65e-06 0.41900 -4.06e-01 -1.05e-01 4.10e-06 2.34e-01
Transport of RCbl within the body 8 2.10e-01 3.42e-01 0.41900 -2.96e-01 2.96e-01 1.47e-01 1.47e-01
Aflatoxin activation and detoxification 14 3.60e-03 1.45e-02 0.41800 -3.07e-01 -2.84e-01 4.67e-02 6.54e-02
Keratan sulfate degradation 9 1.47e-01 2.67e-01 0.41700 -1.91e-01 3.71e-01 3.20e-01 5.40e-02
IRAK1 recruits IKK complex 14 6.77e-02 1.51e-01 0.41600 -2.94e-01 2.94e-01 5.67e-02 5.70e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 6.77e-02 1.51e-01 0.41600 -2.94e-01 2.94e-01 5.67e-02 5.70e-02
Regulation of actin dynamics for phagocytic cup formation 123 6.16e-11 1.03e-09 0.41500 -2.93e-01 2.94e-01 1.91e-08 1.77e-08
InlA-mediated entry of Listeria monocytogenes into host cells 9 9.41e-02 1.94e-01 0.41500 -4.10e-01 6.38e-02 3.32e-02 7.40e-01
Signaling by LTK 10 1.20e-01 2.33e-01 0.41500 3.72e-01 -1.84e-01 4.18e-02 3.13e-01
Activation of NF-kappaB in B cells 54 4.65e-06 3.45e-05 0.41400 -3.90e-01 1.41e-01 7.23e-07 7.28e-02
Cytosolic iron-sulfur cluster assembly 13 8.53e-03 2.97e-02 0.41300 -3.77e-01 -1.69e-01 1.86e-02 2.90e-01
TYSND1 cleaves peroxisomal proteins 7 1.25e-01 2.39e-01 0.41300 -4.13e-01 -1.31e-02 5.86e-02 9.52e-01
eNOS activation 12 6.34e-02 1.44e-01 0.41300 -3.91e-01 1.30e-01 1.89e-02 4.36e-01
NoRC negatively regulates rRNA expression 60 5.22e-07 4.50e-06 0.41200 -3.99e-01 1.02e-01 8.61e-08 1.70e-01
Passive transport by Aquaporins 6 1.73e-01 2.98e-01 0.41000 1.04e-02 4.10e-01 9.65e-01 8.18e-02
Syndecan interactions 26 7.43e-03 2.62e-02 0.41000 -2.65e-01 3.13e-01 1.94e-02 5.70e-03
NrCAM interactions 6 3.18e-01 4.60e-01 0.41000 2.47e-01 -3.27e-01 2.95e-01 1.65e-01
Negative epigenetic regulation of rRNA expression 63 2.47e-07 2.23e-06 0.41000 -3.99e-01 9.43e-02 4.30e-08 1.95e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 3.43e-02 9.16e-02 0.41000 -4.06e-01 5.60e-02 1.12e-02 7.27e-01
Urea cycle 7 2.64e-01 4.07e-01 0.41000 -3.25e-01 2.50e-01 1.37e-01 2.53e-01
Phenylalanine and tyrosine metabolism 9 4.44e-02 1.09e-01 0.40900 -3.88e-01 -1.32e-01 4.40e-02 4.94e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 1.72e-01 2.97e-01 0.40900 -1.46e-01 -3.82e-01 5.72e-01 1.39e-01
Apoptotic factor-mediated response 19 4.75e-03 1.83e-02 0.40900 -4.09e-01 7.31e-03 2.03e-03 9.56e-01
Polymerase switching on the C-strand of the telomere 26 4.81e-05 3.11e-04 0.40900 -2.64e-01 -3.12e-01 1.99e-02 5.83e-03
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.52e-01 2.73e-01 0.40900 -2.55e-01 3.19e-01 1.62e-01 8.05e-02
Aggrephagy 34 1.64e-03 7.28e-03 0.40800 -3.25e-01 2.46e-01 1.02e-03 1.32e-02
Pausing and recovery of Tat-mediated HIV elongation 30 3.32e-04 1.73e-03 0.40700 -4.06e-01 3.22e-02 1.19e-04 7.60e-01
Tat-mediated HIV elongation arrest and recovery 30 3.32e-04 1.73e-03 0.40700 -4.06e-01 3.22e-02 1.19e-04 7.60e-01
Triglyceride biosynthesis 10 3.95e-02 1.01e-01 0.40700 3.97e-01 8.77e-02 2.96e-02 6.31e-01
Processing and activation of SUMO 10 6.93e-02 1.54e-01 0.40700 -4.06e-01 3.16e-02 2.64e-02 8.63e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.72e-02 7.60e-02 0.40600 -3.94e-01 -9.95e-02 2.37e-02 5.68e-01
Specification of primordial germ cells 6 1.65e-01 2.88e-01 0.40600 4.04e-01 4.06e-02 8.64e-02 8.63e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 9.16e-02 1.90e-01 0.40600 3.96e-01 -9.00e-02 3.01e-02 6.22e-01
Mitochondrial Uncoupling 6 1.31e-01 2.48e-01 0.40600 -1.26e-01 -3.86e-01 5.94e-01 1.01e-01
Class I peroxisomal membrane protein import 20 7.58e-04 3.67e-03 0.40600 -3.61e-01 -1.85e-01 5.20e-03 1.52e-01
Formation of TC-NER Pre-Incision Complex 51 1.00e-06 8.17e-06 0.40500 -4.04e-01 1.67e-02 5.81e-07 8.36e-01
Assembly of active LPL and LIPC lipase complexes 10 1.35e-01 2.51e-01 0.40500 -1.86e-01 3.59e-01 3.08e-01 4.92e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 7 2.40e-01 3.79e-01 0.40400 3.65e-01 -1.73e-01 9.41e-02 4.27e-01
RHO GTPases activate IQGAPs 25 5.21e-03 1.97e-02 0.40400 -1.54e-01 3.74e-01 1.81e-01 1.22e-03
Toxicity of botulinum toxin type D (botD) 5 3.57e-01 4.99e-01 0.40300 1.64e-01 -3.69e-01 5.26e-01 1.54e-01
Toxicity of botulinum toxin type F (botF) 5 3.57e-01 4.99e-01 0.40300 1.64e-01 -3.69e-01 5.26e-01 1.54e-01
Interleukin-1 processing 8 2.38e-01 3.76e-01 0.40100 2.74e-01 -2.93e-01 1.79e-01 1.52e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 4.08e-01 5.54e-01 0.40000 3.01e-01 -2.64e-01 2.44e-01 3.07e-01
The activation of arylsulfatases 10 1.57e-01 2.80e-01 0.40000 -3.31e-01 2.25e-01 6.97e-02 2.19e-01
2-LTR circle formation 7 7.64e-02 1.67e-01 0.40000 -2.76e-01 -2.89e-01 2.05e-01 1.85e-01
Senescence-Associated Secretory Phenotype (SASP) 65 6.76e-06 4.93e-05 0.39900 -3.28e-01 2.28e-01 4.75e-06 1.49e-03
Regulated proteolysis of p75NTR 11 1.20e-01 2.34e-01 0.39900 -1.90e-01 3.51e-01 2.74e-01 4.38e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 76 1.22e-08 1.36e-07 0.39900 -3.93e-01 6.68e-02 2.99e-09 3.14e-01
DNA strand elongation 32 1.04e-05 7.34e-05 0.39900 -3.27e-01 -2.27e-01 1.35e-03 2.61e-02
RSK activation 7 2.17e-01 3.51e-01 0.39800 -1.16e-01 3.81e-01 5.94e-01 8.09e-02
Protein lipoylation 10 3.96e-02 1.02e-01 0.39700 -3.79e-01 -1.20e-01 3.81e-02 5.10e-01
Signaling by the B Cell Receptor (BCR) 150 3.38e-12 6.87e-11 0.39700 -3.08e-01 2.50e-01 7.64e-11 1.21e-07
BBSome-mediated cargo-targeting to cilium 22 4.01e-04 2.05e-03 0.39600 -2.31e-01 -3.22e-01 6.12e-02 8.86e-03
Glycosphingolipid biosynthesis 15 1.32e-02 4.25e-02 0.39600 3.93e-01 4.63e-02 8.40e-03 7.56e-01
Long-term potentiation 18 4.17e-02 1.04e-01 0.39500 2.42e-01 -3.12e-01 7.60e-02 2.18e-02
Diseases associated with N-glycosylation of proteins 20 9.52e-03 3.24e-02 0.39500 -3.88e-01 7.10e-02 2.65e-03 5.83e-01
Myogenesis 21 6.45e-03 2.33e-02 0.39400 3.91e-01 -5.36e-02 1.94e-03 6.71e-01
Diseases of branched-chain amino acid catabolism 13 3.32e-02 8.93e-02 0.39400 -3.94e-01 5.26e-03 1.39e-02 9.74e-01
Recycling of bile acids and salts 10 1.66e-01 2.89e-01 0.39400 3.28e-01 -2.18e-01 7.26e-02 2.33e-01
Infection with Mycobacterium tuberculosis 26 1.15e-02 3.79e-02 0.39300 -2.79e-01 2.77e-01 1.39e-02 1.45e-02
TP53 Regulates Transcription of Death Receptors and Ligands 12 9.21e-02 1.91e-01 0.39300 3.63e-01 -1.49e-01 2.94e-02 3.70e-01
Heme degradation 11 1.25e-01 2.40e-01 0.39300 -3.49e-01 1.79e-01 4.48e-02 3.04e-01
Degradation of cysteine and homocysteine 13 1.82e-02 5.44e-02 0.39300 -3.79e-01 -1.01e-01 1.79e-02 5.27e-01
Signaling by FGFR2 IIIa TM 18 1.03e-02 3.44e-02 0.39200 -3.91e-01 1.50e-02 4.05e-03 9.12e-01
FGFR2 alternative splicing 25 5.13e-03 1.95e-02 0.38900 -3.74e-01 1.07e-01 1.19e-03 3.57e-01
mRNA Capping 29 6.06e-04 2.98e-03 0.38900 -3.89e-01 4.10e-03 2.91e-04 9.70e-01
DNA Damage Recognition in GG-NER 38 9.21e-05 5.46e-04 0.38800 -3.87e-01 2.70e-02 3.56e-05 7.73e-01
PERK regulates gene expression 30 2.46e-03 1.04e-02 0.38800 -3.66e-01 1.30e-01 5.28e-04 2.16e-01
Cyclin E associated events during G1/S transition 73 1.31e-07 1.24e-06 0.38800 -3.78e-01 8.71e-02 2.31e-08 1.98e-01
Downregulation of ERBB4 signaling 8 1.46e-01 2.65e-01 0.38800 -3.86e-01 3.44e-02 5.85e-02 8.66e-01
G2/M Checkpoints 126 9.46e-12 1.76e-10 0.38700 -3.67e-01 1.21e-01 1.05e-12 1.87e-02
SARS-CoV-2 modulates autophagy 11 2.29e-02 6.61e-02 0.38700 -2.74e-01 -2.73e-01 1.16e-01 1.17e-01
TGFBR3 PTM regulation 10 1.89e-01 3.17e-01 0.38600 -2.55e-01 2.90e-01 1.63e-01 1.12e-01
Adenylate cyclase inhibitory pathway 11 7.26e-02 1.60e-01 0.38600 3.84e-01 -3.43e-02 2.72e-02 8.44e-01
Nef Mediated CD4 Down-regulation 9 1.40e-01 2.57e-01 0.38600 -3.78e-01 7.98e-02 4.98e-02 6.79e-01
Smooth Muscle Contraction 34 3.61e-03 1.46e-02 0.38500 -2.82e-01 2.63e-01 4.45e-03 7.98e-03
Axonal growth inhibition (RHOA activation) 7 3.05e-01 4.46e-01 0.38500 -3.12e-01 2.26e-01 1.53e-01 3.01e-01
p75NTR regulates axonogenesis 7 3.05e-01 4.46e-01 0.38500 -3.12e-01 2.26e-01 1.53e-01 3.01e-01
Synthesis of PIPs at the Golgi membrane 16 6.46e-02 1.46e-01 0.38500 2.16e-01 -3.19e-01 1.34e-01 2.73e-02
Generation of second messenger molecules 38 1.83e-04 1.01e-03 0.38500 5.68e-02 -3.81e-01 5.45e-01 4.91e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 2.61e-10 3.84e-09 0.38500 -3.75e-01 -8.73e-02 1.61e-08 1.88e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 4.06e-05 2.66e-04 0.38400 -3.84e-01 2.36e-02 1.69e-05 7.91e-01
HIV Transcription Elongation 42 4.06e-05 2.66e-04 0.38400 -3.84e-01 2.36e-02 1.69e-05 7.91e-01
Tat-mediated elongation of the HIV-1 transcript 42 4.06e-05 2.66e-04 0.38400 -3.84e-01 2.36e-02 1.69e-05 7.91e-01
Formation of Incision Complex in GG-NER 43 4.50e-05 2.93e-04 0.38400 -3.82e-01 4.03e-02 1.47e-05 6.48e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 7.69e-02 1.68e-01 0.38400 -3.74e-01 8.34e-02 2.47e-02 6.17e-01
tRNA processing 128 1.02e-13 2.69e-12 0.38300 -3.82e-01 3.53e-02 8.36e-14 4.91e-01
DNA Damage/Telomere Stress Induced Senescence 42 3.76e-04 1.94e-03 0.38300 -3.53e-01 1.48e-01 7.51e-05 9.59e-02
RNA Polymerase I Promoter Clearance 64 1.35e-06 1.08e-05 0.38200 -3.72e-01 8.37e-02 2.54e-07 2.47e-01
RNA Polymerase I Transcription 64 1.35e-06 1.08e-05 0.38200 -3.72e-01 8.37e-02 2.54e-07 2.47e-01
N-glycan trimming and elongation in the cis-Golgi 5 3.42e-01 4.85e-01 0.38100 -3.74e-01 7.51e-02 1.48e-01 7.71e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 1.00e-03 4.69e-03 0.38100 -3.81e-01 -1.78e-02 6.11e-04 8.73e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.00e-03 4.69e-03 0.38100 -3.81e-01 -1.78e-02 6.11e-04 8.73e-01
Signal transduction by L1 20 3.74e-02 9.78e-02 0.38100 -3.00e-01 2.35e-01 2.01e-02 6.89e-02
GABA synthesis, release, reuptake and degradation 12 5.97e-02 1.38e-01 0.38100 2.85e-02 -3.80e-01 8.64e-01 2.26e-02
Early Phase of HIV Life Cycle 14 9.91e-03 3.35e-02 0.38100 -3.06e-01 -2.26e-01 4.71e-02 1.42e-01
FCGR3A-mediated IL10 synthesis 99 1.12e-07 1.07e-06 0.38100 -2.48e-01 2.89e-01 1.98e-05 6.92e-07
Suppression of apoptosis 7 2.82e-01 4.25e-01 0.38000 -1.63e-01 3.44e-01 4.56e-01 1.15e-01
Purine catabolism 16 4.27e-02 1.06e-01 0.38000 -3.62e-01 1.14e-01 1.21e-02 4.29e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.56e-03 1.07e-02 0.38000 -3.72e-01 7.36e-02 6.46e-04 5.00e-01
Aryl hydrocarbon receptor signalling 6 1.50e-01 2.70e-01 0.38000 -3.34e-01 -1.80e-01 1.56e-01 4.46e-01
ER-Phagosome pathway 75 9.41e-07 7.80e-06 0.37900 -3.51e-01 1.43e-01 1.47e-07 3.18e-02
Fructose catabolism 5 1.93e-01 3.22e-01 0.37900 -2.60e-01 -2.76e-01 3.15e-01 2.85e-01
HIV elongation arrest and recovery 32 7.75e-04 3.73e-03 0.37800 -3.76e-01 4.54e-02 2.34e-04 6.57e-01
Pausing and recovery of HIV elongation 32 7.75e-04 3.73e-03 0.37800 -3.76e-01 4.54e-02 2.34e-04 6.57e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 7.71e-02 1.68e-01 0.37800 -2.49e-01 2.85e-01 8.51e-02 4.81e-02
Telomere C-strand (Lagging Strand) Synthesis 34 1.48e-05 1.02e-04 0.37800 -2.83e-01 -2.50e-01 4.25e-03 1.16e-02
Formation of Fibrin Clot (Clotting Cascade) 26 9.70e-03 3.28e-02 0.37800 -1.59e-01 3.42e-01 1.59e-01 2.52e-03
PCP/CE pathway 75 9.77e-07 8.06e-06 0.37700 -3.51e-01 1.37e-01 1.48e-07 4.04e-02
Olfactory Signaling Pathway 61 3.12e-09 3.74e-08 0.37600 2.25e-01 3.02e-01 2.42e-03 4.50e-05
Synthesis of 5-eicosatetraenoic acids 7 2.37e-01 3.75e-01 0.37600 -8.04e-02 3.67e-01 7.13e-01 9.28e-02
Activation of the phototransduction cascade 8 8.56e-02 1.81e-01 0.37500 1.70e-01 3.34e-01 4.05e-01 1.01e-01
Regulation of IFNA/IFNB signaling 12 1.42e-01 2.60e-01 0.37500 3.11e-01 -2.09e-01 6.21e-02 2.09e-01
Amine ligand-binding receptors 10 2.11e-01 3.42e-01 0.37400 2.67e-01 -2.63e-01 1.44e-01 1.51e-01
Scavenging by Class A Receptors 14 1.13e-01 2.24e-01 0.37400 -2.61e-01 2.68e-01 9.11e-02 8.25e-02
Diseases of programmed cell death 58 9.41e-06 6.71e-05 0.37400 -3.63e-01 8.88e-02 1.73e-06 2.42e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.15e-02 3.79e-02 0.37300 -3.69e-01 -5.78e-02 8.44e-03 6.80e-01
Signaling by FGFR4 in disease 11 8.21e-02 1.76e-01 0.37300 3.72e-01 -2.25e-02 3.25e-02 8.97e-01
Pyrimidine salvage 10 2.07e-01 3.38e-01 0.37300 -2.96e-01 2.27e-01 1.05e-01 2.14e-01
SARS-CoV-1-host interactions 95 6.43e-11 1.06e-09 0.37200 -3.72e-01 -2.57e-02 3.81e-10 6.65e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 7 1.12e-01 2.22e-01 0.37200 3.07e-01 2.11e-01 1.60e-01 3.34e-01
Interleukin-2 family signaling 38 1.34e-03 6.10e-03 0.37200 3.39e-01 -1.54e-01 3.02e-04 1.00e-01
mRNA Splicing 211 8.82e-24 3.62e-22 0.37200 -3.70e-01 -3.96e-02 1.82e-20 3.22e-01
Sulfur amino acid metabolism 23 2.39e-03 1.02e-02 0.37100 -3.65e-01 -6.59e-02 2.46e-03 5.85e-01
NR1H2 and NR1H3-mediated signaling 39 2.27e-03 9.68e-03 0.37100 2.21e-01 -2.98e-01 1.71e-02 1.30e-03
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 5.35e-05 3.38e-04 0.37000 -3.55e-01 1.05e-01 9.49e-06 1.90e-01
Azathioprine ADME 21 5.40e-03 2.03e-02 0.37000 -3.68e-01 -3.54e-02 3.48e-03 7.79e-01
Negative regulation of FGFR3 signaling 21 4.08e-02 1.03e-01 0.36900 -2.45e-01 2.76e-01 5.18e-02 2.85e-02
Signaling by activated point mutants of FGFR1 5 4.45e-01 5.83e-01 0.36900 -1.87e-01 3.18e-01 4.68e-01 2.18e-01
CREB3 factors activate genes 6 4.01e-01 5.45e-01 0.36900 -2.46e-01 2.76e-01 2.98e-01 2.42e-01
Sphingolipid de novo biosynthesis 34 5.56e-03 2.09e-02 0.36900 -2.37e-01 2.83e-01 1.68e-02 4.29e-03
Expression and translocation of olfactory receptors 56 2.80e-08 2.97e-07 0.36900 2.35e-01 2.85e-01 2.39e-03 2.28e-04
IkBA variant leads to EDA-ID 7 2.12e-01 3.44e-01 0.36900 3.68e-01 -2.31e-02 9.17e-02 9.16e-01
Glutathione synthesis and recycling 10 4.57e-02 1.12e-01 0.36800 -2.91e-01 -2.25e-01 1.11e-01 2.17e-01
Incretin synthesis, secretion, and inactivation 14 8.44e-02 1.80e-01 0.36800 -3.43e-01 1.33e-01 2.63e-02 3.88e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 8.44e-02 1.80e-01 0.36800 -3.43e-01 1.33e-01 2.63e-02 3.88e-01
RNA Polymerase III Transcription Initiation 36 6.18e-04 3.03e-03 0.36800 -3.63e-01 5.86e-02 1.63e-04 5.43e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 4.62e-08 4.80e-07 0.36800 -3.54e-01 -1.01e-01 1.45e-06 1.69e-01
G1/S Transition 120 1.93e-11 3.43e-10 0.36700 -3.63e-01 5.46e-02 6.22e-12 3.01e-01
Signaling by NOTCH4 70 4.46e-06 3.34e-05 0.36700 -3.43e-01 1.31e-01 7.02e-07 5.85e-02
TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.65e-01 2.89e-01 0.36700 2.49e-01 -2.70e-01 1.36e-01 1.06e-01
Signaling by Erythropoietin 24 7.80e-03 2.74e-02 0.36600 3.61e-01 -6.22e-02 2.19e-03 5.98e-01
RUNX3 Regulates Immune Response and Cell Migration 6 2.30e-01 3.66e-01 0.36600 3.64e-01 3.72e-02 1.22e-01 8.75e-01
RAS processing 23 3.02e-02 8.25e-02 0.36600 -2.92e-01 2.22e-01 1.55e-02 6.59e-02
COPI-independent Golgi-to-ER retrograde traffic 45 1.19e-03 5.49e-03 0.36500 -2.36e-01 2.79e-01 6.12e-03 1.20e-03
DCC mediated attractive signaling 13 1.23e-01 2.38e-01 0.36500 -3.20e-01 1.75e-01 4.54e-02 2.73e-01
Anti-inflammatory response favouring Leishmania parasite infection 132 2.53e-09 3.15e-08 0.36500 -2.25e-01 2.88e-01 8.12e-06 1.14e-08
Leishmania parasite growth and survival 132 2.53e-09 3.15e-08 0.36500 -2.25e-01 2.88e-01 8.12e-06 1.14e-08
Dual incision in TC-NER 63 7.35e-08 7.28e-07 0.36500 -3.56e-01 -8.09e-02 1.02e-06 2.67e-01
Frs2-mediated activation 11 1.38e-01 2.55e-01 0.36400 -1.13e-01 3.46e-01 5.17e-01 4.66e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.46e-10 6.29e-09 0.36400 -3.57e-01 -7.29e-02 1.55e-08 2.48e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 9.13e-05 5.42e-04 0.36400 -3.63e-01 3.37e-02 3.14e-05 6.99e-01
mRNA Splicing - Major Pathway 203 5.82e-22 2.30e-20 0.36400 -3.61e-01 -4.00e-02 6.36e-19 3.26e-01
TRAF3-dependent IRF activation pathway 13 1.48e-01 2.68e-01 0.36300 2.60e-01 -2.54e-01 1.05e-01 1.12e-01
Vitamin C (ascorbate) metabolism 8 2.79e-01 4.23e-01 0.36300 3.20e-01 -1.70e-01 1.17e-01 4.06e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 8.32e-03 2.91e-02 0.36300 -2.92e-01 2.15e-01 4.27e-03 3.52e-02
Mitotic Telophase/Cytokinesis 13 1.11e-01 2.20e-01 0.36200 3.35e-01 -1.37e-01 3.63e-02 3.93e-01
RNA Polymerase III Abortive And Retractive Initiation 41 2.84e-04 1.50e-03 0.36200 -3.58e-01 5.69e-02 7.42e-05 5.28e-01
RNA Polymerase III Transcription 41 2.84e-04 1.50e-03 0.36200 -3.58e-01 5.69e-02 7.42e-05 5.28e-01
Initiation of Nuclear Envelope (NE) Reformation 19 5.80e-02 1.35e-01 0.36200 -2.94e-01 2.11e-01 2.65e-02 1.11e-01
Translesion Synthesis by POLH 18 1.40e-02 4.44e-02 0.36200 -3.60e-01 -3.32e-02 8.17e-03 8.07e-01
Crosslinking of collagen fibrils 15 1.50e-02 4.68e-02 0.36100 1.47e-01 3.30e-01 3.24e-01 2.69e-02
Metabolism of nucleotides 85 5.28e-09 6.11e-08 0.36100 -3.61e-01 -7.18e-03 8.96e-09 9.09e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 3.91e-03 1.56e-02 0.36100 -3.20e-01 1.67e-01 1.06e-03 8.73e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.42e-02 1.45e-01 0.36000 3.54e-01 6.75e-02 4.20e-02 6.98e-01
Nef Mediated CD8 Down-regulation 7 3.55e-01 4.98e-01 0.36000 -2.92e-01 2.11e-01 1.82e-01 3.33e-01
p75NTR negatively regulates cell cycle via SC1 5 3.08e-01 4.49e-01 0.36000 -3.58e-01 -3.41e-02 1.65e-01 8.95e-01
Cyclin A:Cdk2-associated events at S phase entry 75 5.65e-07 4.83e-06 0.36000 -3.53e-01 6.75e-02 1.22e-07 3.12e-01
Negative regulation of FGFR1 signaling 25 2.57e-02 7.29e-02 0.36000 -2.19e-01 2.85e-01 5.80e-02 1.36e-02
Cell surface interactions at the vascular wall 176 1.45e-11 2.65e-10 0.35800 -2.52e-01 2.54e-01 8.01e-09 5.71e-09
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 30 4.03e-03 1.59e-02 0.35800 -3.48e-01 8.37e-02 9.67e-04 4.28e-01
Wax and plasmalogen biosynthesis 5 3.56e-01 4.99e-01 0.35700 -3.56e-01 2.70e-02 1.68e-01 9.17e-01
Organic anion transporters 7 1.65e-01 2.89e-01 0.35700 -9.75e-02 -3.43e-01 6.55e-01 1.16e-01
NFE2L2 regulating tumorigenic genes 11 4.09e-02 1.03e-01 0.35600 2.74e-01 2.28e-01 1.16e-01 1.90e-01
Regulation of gene expression in beta cells 8 2.81e-01 4.23e-01 0.35600 3.23e-01 -1.51e-01 1.14e-01 4.58e-01
Nuclear events mediated by NFE2L2 82 3.70e-06 2.80e-05 0.35600 -3.12e-01 1.72e-01 1.02e-06 7.09e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 1.26e-01 2.41e-01 0.35600 -3.00e-01 1.91e-01 5.18e-02 2.17e-01
Cellular hexose transport 14 4.86e-02 1.18e-01 0.35600 -1.53e-03 -3.56e-01 9.92e-01 2.13e-02
Polo-like kinase mediated events 16 9.19e-02 1.91e-01 0.35500 -3.05e-01 1.82e-01 3.47e-02 2.08e-01
Glycosphingolipid transport 7 1.54e-01 2.75e-01 0.35500 -1.35e-01 -3.28e-01 5.37e-01 1.32e-01
ABC-family proteins mediated transport 81 2.46e-06 1.90e-05 0.35500 -3.25e-01 1.41e-01 4.17e-07 2.80e-02
Netrin mediated repulsion signals 5 4.65e-01 6.00e-01 0.35400 1.64e-01 -3.14e-01 5.25e-01 2.24e-01
Pregnenolone biosynthesis 10 6.20e-02 1.42e-01 0.35400 -3.07e-01 -1.77e-01 9.28e-02 3.33e-01
Extension of Telomeres 51 4.56e-06 3.40e-05 0.35400 -3.48e-01 -6.72e-02 1.73e-05 4.06e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 2.38e-01 3.76e-01 0.35300 -2.50e-01 -2.50e-01 3.33e-01 3.34e-01
Neurexins and neuroligins 40 3.80e-03 1.53e-02 0.35300 2.64e-01 -2.34e-01 3.81e-03 1.03e-02
CD209 (DC-SIGN) signaling 20 5.71e-02 1.33e-01 0.35300 2.89e-01 -2.03e-01 2.53e-02 1.15e-01
PI-3K cascade:FGFR1 13 2.67e-02 7.50e-02 0.35300 1.88e-01 2.99e-01 2.40e-01 6.23e-02
Glycosphingolipid catabolism 31 5.76e-03 2.14e-02 0.35300 -3.33e-01 1.16e-01 1.32e-03 2.63e-01
Signaling by BMP 23 2.64e-02 7.45e-02 0.35300 3.23e-01 -1.41e-01 7.28e-03 2.43e-01
Cytochrome c-mediated apoptotic response 13 9.81e-02 2.00e-01 0.35200 -3.43e-01 8.11e-02 3.23e-02 6.13e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 3.64e-04 1.88e-03 0.35200 -3.20e-01 1.47e-01 7.77e-05 6.92e-02
Interleukin-10 signaling 38 2.80e-03 1.16e-02 0.35100 3.19e-01 -1.48e-01 6.68e-04 1.15e-01
OAS antiviral response 8 1.36e-01 2.51e-01 0.35100 -9.84e-02 -3.37e-01 6.30e-01 9.86e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 4.85e-05 3.11e-04 0.35100 -3.25e-01 -1.33e-01 5.27e-04 1.54e-01
DNA Damage Reversal 8 1.54e-01 2.75e-01 0.35100 -3.46e-01 -5.74e-02 8.97e-02 7.78e-01
Maturation of spike protein 9694548 36 7.23e-03 2.56e-02 0.35100 -2.54e-01 2.42e-01 8.27e-03 1.21e-02
NFE2L2 regulating ER-stress associated genes 5 2.61e-01 4.04e-01 0.35000 3.11e-01 1.61e-01 2.29e-01 5.33e-01
Synthesis of 12-eicosatetraenoic acid derivatives 6 4.22e-01 5.64e-01 0.35000 -2.97e-01 1.85e-01 2.08e-01 4.32e-01
Lysosome Vesicle Biogenesis 32 4.36e-03 1.70e-02 0.35000 -3.36e-01 9.72e-02 9.98e-04 3.41e-01
Prolonged ERK activation events 13 8.68e-02 1.83e-01 0.34900 -4.89e-02 3.46e-01 7.60e-01 3.08e-02
Defective GALNT12 causes CRCS1 9 1.86e-01 3.13e-01 0.34900 3.45e-01 -5.06e-02 7.27e-02 7.93e-01
Myoclonic epilepsy of Lafora 8 3.02e-01 4.44e-01 0.34900 -3.12e-01 1.57e-01 1.27e-01 4.41e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.15e-02 3.80e-02 0.34900 -3.33e-01 -1.04e-01 1.46e-02 4.43e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.50e-02 7.11e-02 0.34800 -3.44e-01 5.41e-02 7.76e-03 6.75e-01
AKT phosphorylates targets in the nucleus 9 2.49e-01 3.89e-01 0.34800 1.37e-01 -3.20e-01 4.77e-01 9.68e-02
NF-kB is activated and signals survival 12 1.68e-01 2.92e-01 0.34800 -3.10e-01 1.57e-01 6.28e-02 3.46e-01
RHO GTPases Activate Rhotekin and Rhophilins 8 2.95e-01 4.38e-01 0.34700 -3.17e-01 1.41e-01 1.20e-01 4.90e-01
Paracetamol ADME 19 1.22e-02 3.96e-02 0.34700 -3.41e-01 -6.53e-02 1.00e-02 6.22e-01
NOTCH2 intracellular domain regulates transcription 11 1.72e-01 2.97e-01 0.34700 3.27e-01 -1.17e-01 6.07e-02 5.01e-01
Biotin transport and metabolism 11 5.01e-02 1.21e-01 0.34600 -2.04e-01 -2.80e-01 2.42e-01 1.08e-01
Xenobiotics 12 2.02e-01 3.32e-01 0.34600 2.30e-01 -2.58e-01 1.69e-01 1.21e-01
RUNX3 regulates p14-ARF 10 6.48e-02 1.46e-01 0.34500 2.36e-01 2.52e-01 1.97e-01 1.67e-01
Ribavirin ADME 11 9.27e-02 1.91e-01 0.34500 -3.43e-01 -3.30e-02 4.86e-02 8.50e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 9.42e-02 1.94e-01 0.34500 -3.41e-01 5.22e-02 3.33e-02 7.44e-01
Fc epsilon receptor (FCERI) signaling 179 6.54e-11 1.07e-09 0.34400 -2.52e-01 2.34e-01 5.58e-09 6.94e-08
Sema4D induced cell migration and growth-cone collapse 19 5.51e-02 1.31e-01 0.34300 -1.28e-01 3.19e-01 3.35e-01 1.62e-02
Inactivation, recovery and regulation of the phototransduction cascade 25 3.43e-02 9.16e-02 0.34200 -1.95e-01 2.82e-01 9.18e-02 1.48e-02
RHOBTB1 GTPase cycle 23 4.14e-02 1.04e-01 0.34200 -2.93e-01 1.76e-01 1.49e-02 1.43e-01
HIV Transcription Initiation 45 6.51e-05 3.98e-04 0.34200 -3.40e-01 -3.77e-02 7.97e-05 6.62e-01
RNA Polymerase II HIV Promoter Escape 45 6.51e-05 3.98e-04 0.34200 -3.40e-01 -3.77e-02 7.97e-05 6.62e-01
RNA Polymerase II Promoter Escape 45 6.51e-05 3.98e-04 0.34200 -3.40e-01 -3.77e-02 7.97e-05 6.62e-01
RNA Polymerase II Transcription Initiation 45 6.51e-05 3.98e-04 0.34200 -3.40e-01 -3.77e-02 7.97e-05 6.62e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 6.51e-05 3.98e-04 0.34200 -3.40e-01 -3.77e-02 7.97e-05 6.62e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 6.51e-05 3.98e-04 0.34200 -3.40e-01 -3.77e-02 7.97e-05 6.62e-01
Nuclear Receptor transcription pathway 40 4.63e-03 1.79e-02 0.34200 2.81e-01 -1.94e-01 2.08e-03 3.35e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 8.11e-03 2.84e-02 0.34200 -3.31e-01 8.43e-02 2.01e-03 4.32e-01
TGFBR3 regulates TGF-beta signaling 8 3.09e-01 4.50e-01 0.34200 1.42e-01 -3.11e-01 4.87e-01 1.28e-01
HDR through MMEJ (alt-NHEJ) 12 9.05e-02 1.89e-01 0.34100 -4.06e-03 -3.41e-01 9.81e-01 4.06e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.60e-02 4.94e-02 0.34100 -2.93e-01 1.75e-01 5.44e-03 9.79e-02
PI-3K cascade:FGFR3 10 6.99e-02 1.55e-01 0.34100 2.25e-01 2.56e-01 2.18e-01 1.61e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 2.43e-01 3.82e-01 0.34000 3.02e-01 -1.56e-01 9.77e-02 3.92e-01
Peroxisomal protein import 58 2.78e-06 2.14e-05 0.33900 -3.33e-01 -6.32e-02 1.13e-05 4.05e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 1.61e-01 2.83e-01 0.33900 -1.15e-01 3.19e-01 4.90e-01 5.60e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 6 3.02e-01 4.44e-01 0.33900 3.38e-01 1.05e-02 1.51e-01 9.65e-01
Positive epigenetic regulation of rRNA expression 60 1.03e-04 6.03e-04 0.33800 -3.20e-01 1.10e-01 1.82e-05 1.42e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 1.29e-02 4.14e-02 0.33800 -3.34e-01 5.21e-02 3.84e-03 6.52e-01
Phase 4 - resting membrane potential 9 3.05e-01 4.46e-01 0.33700 2.81e-01 -1.87e-01 1.44e-01 3.31e-01
Attachment of GPI anchor to uPAR 7 1.93e-01 3.23e-01 0.33700 -1.07e-01 -3.20e-01 6.23e-01 1.43e-01
Chaperone Mediated Autophagy 20 5.30e-02 1.26e-01 0.33700 -3.13e-01 1.27e-01 1.55e-02 3.27e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 7 3.53e-01 4.96e-01 0.33700 1.19e-01 -3.15e-01 5.85e-01 1.49e-01
Glycogen metabolism 21 6.13e-02 1.41e-01 0.33700 -1.78e-01 2.86e-01 1.59e-01 2.33e-02
Nef and signal transduction 8 2.47e-01 3.87e-01 0.33600 3.33e-01 -4.66e-02 1.03e-01 8.20e-01
Activation of the pre-replicative complex 32 1.56e-03 6.93e-03 0.33600 -3.36e-01 -2.33e-02 1.01e-03 8.20e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 5.83e-02 1.36e-01 0.33600 -2.93e-01 1.65e-01 2.02e-02 1.90e-01
Neurodegenerative Diseases 21 5.83e-02 1.36e-01 0.33600 -2.93e-01 1.65e-01 2.02e-02 1.90e-01
Heme signaling 45 1.55e-03 6.93e-03 0.33500 3.09e-01 -1.31e-01 3.38e-04 1.29e-01
Nucleotide Excision Repair 108 7.43e-11 1.20e-09 0.33500 -3.29e-01 -6.44e-02 3.42e-09 2.47e-01
Integration of provirus 9 1.00e-01 2.04e-01 0.33500 -2.69e-01 -2.01e-01 1.63e-01 2.97e-01
HDL assembly 6 3.18e-01 4.61e-01 0.33400 3.34e-01 4.55e-04 1.56e-01 9.98e-01
Organic cation transport 8 1.60e-01 2.82e-01 0.33400 1.03e-01 3.18e-01 6.14e-01 1.19e-01
Organic cation/anion/zwitterion transport 8 1.60e-01 2.82e-01 0.33400 1.03e-01 3.18e-01 6.14e-01 1.19e-01
Synthesis of PE 12 1.94e-01 3.23e-01 0.33300 -1.47e-01 2.98e-01 3.76e-01 7.35e-02
Caspase activation via Death Receptors in the presence of ligand 16 1.32e-01 2.48e-01 0.33300 2.70e-01 -1.94e-01 6.14e-02 1.78e-01
FGFR2 mutant receptor activation 23 1.08e-02 3.59e-02 0.33200 -3.32e-01 -2.23e-02 5.90e-03 8.53e-01
Amino acids regulate mTORC1 48 2.66e-03 1.11e-02 0.33100 -2.58e-01 2.08e-01 1.98e-03 1.26e-02
PI3K events in ERBB2 signaling 11 1.04e-01 2.11e-01 0.33100 3.28e-01 4.78e-02 5.98e-02 7.84e-01
Erythrocytes take up carbon dioxide and release oxygen 11 6.61e-02 1.49e-01 0.33100 1.89e-01 2.71e-01 2.78e-01 1.19e-01
O2/CO2 exchange in erythrocytes 11 6.61e-02 1.49e-01 0.33100 1.89e-01 2.71e-01 2.78e-01 1.19e-01
Fibronectin matrix formation 6 4.53e-01 5.89e-01 0.33000 -1.56e-01 2.91e-01 5.09e-01 2.17e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.24e-02 6.50e-02 0.33000 -3.14e-01 -1.02e-01 2.52e-02 4.65e-01
Cell Cycle Checkpoints 246 4.47e-16 1.37e-14 0.33000 -3.11e-01 1.09e-01 4.18e-17 3.24e-03
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 7 3.33e-01 4.74e-01 0.32900 3.21e-01 -7.29e-02 1.41e-01 7.38e-01
SHC-related events triggered by IGF1R 8 2.67e-01 4.10e-01 0.32900 3.25e-01 -5.17e-02 1.11e-01 8.00e-01
Transport of nucleotide sugars 9 2.45e-01 3.84e-01 0.32900 -3.21e-01 7.48e-02 9.57e-02 6.98e-01
Late endosomal microautophagy 30 1.02e-02 3.41e-02 0.32900 -3.18e-01 8.38e-02 2.55e-03 4.27e-01
Processing of Capped Intron-Containing Pre-mRNA 279 1.05e-24 4.49e-23 0.32900 -3.27e-01 -3.96e-02 5.48e-21 2.55e-01
Macroautophagy 128 3.11e-08 3.26e-07 0.32900 -2.99e-01 1.37e-01 5.30e-09 7.22e-03
Sema4D in semaphorin signaling 22 5.60e-02 1.32e-01 0.32800 -1.54e-01 2.90e-01 2.12e-01 1.84e-02
Diseases of Base Excision Repair 5 3.00e-01 4.44e-01 0.32800 -2.80e-01 -1.72e-01 2.78e-01 5.07e-01
RNA Polymerase II Transcription Termination 66 6.50e-06 4.78e-05 0.32800 -3.28e-01 5.97e-03 3.99e-06 9.33e-01
ABC transporters in lipid homeostasis 14 1.34e-01 2.50e-01 0.32700 3.10e-01 -1.06e-01 4.48e-02 4.92e-01
Branched-chain amino acid catabolism 21 2.00e-02 5.87e-02 0.32700 -3.27e-01 -1.13e-02 9.57e-03 9.28e-01
Mitotic G1 phase and G1/S transition 138 2.38e-10 3.53e-09 0.32700 -3.22e-01 5.39e-02 6.22e-11 2.74e-01
Diseases of Mismatch Repair (MMR) 5 4.60e-01 5.96e-01 0.32600 -3.19e-01 6.96e-02 2.17e-01 7.87e-01
Separation of Sister Chromatids 168 1.19e-10 1.83e-09 0.32600 -3.01e-01 1.23e-01 1.52e-11 5.77e-03
Diseases associated with glycosylation precursor biosynthesis 15 1.20e-01 2.34e-01 0.32600 -3.07e-01 1.09e-01 3.96e-02 4.64e-01
Sodium/Calcium exchangers 9 3.46e-01 4.89e-01 0.32600 -2.33e-01 2.28e-01 2.26e-01 2.37e-01
Transcription of the HIV genome 67 9.09e-06 6.51e-05 0.32600 -3.25e-01 1.85e-02 4.16e-06 7.93e-01
Telomere C-strand synthesis initiation 13 4.24e-02 1.06e-01 0.32600 -2.20e-01 -2.40e-01 1.69e-01 1.35e-01
Signaling by MST1 5 3.00e-01 4.44e-01 0.32500 -2.58e-01 -1.98e-01 3.17e-01 4.44e-01
Signaling by WNT in cancer 30 1.72e-03 7.56e-03 0.32400 3.12e-01 8.92e-02 3.10e-03 3.98e-01
UCH proteinases 73 2.65e-05 1.77e-04 0.32400 -3.10e-01 9.40e-02 4.52e-06 1.65e-01
Mitotic Anaphase 211 4.19e-13 1.01e-11 0.32400 -3.01e-01 1.21e-01 4.80e-14 2.47e-03
Mitotic Metaphase and Anaphase 212 4.29e-13 1.02e-11 0.32300 -3.00e-01 1.19e-01 4.85e-14 2.76e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.59e-02 9.44e-02 0.32300 2.97e-01 1.26e-01 4.64e-02 3.97e-01
SMAC (DIABLO) binds to IAPs 7 2.31e-01 3.67e-01 0.32300 -3.11e-01 -8.69e-02 1.55e-01 6.91e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 2.31e-01 3.67e-01 0.32300 -3.11e-01 -8.69e-02 1.55e-01 6.91e-01
SMAC, XIAP-regulated apoptotic response 7 2.31e-01 3.67e-01 0.32300 -3.11e-01 -8.69e-02 1.55e-01 6.91e-01
Retrograde neurotrophin signalling 12 1.92e-01 3.21e-01 0.32200 -3.03e-01 1.11e-01 6.95e-02 5.06e-01
RUNX3 regulates NOTCH signaling 14 4.50e-02 1.11e-01 0.32200 2.95e-01 1.28e-01 5.56e-02 4.06e-01
IL-6-type cytokine receptor ligand interactions 13 2.14e-01 3.46e-01 0.32200 2.61e-01 -1.88e-01 1.03e-01 2.40e-01
Unfolded Protein Response (UPR) 84 5.77e-05 3.61e-04 0.32200 -2.51e-01 2.01e-01 7.02e-05 1.44e-03
DNA Damage Bypass 47 5.31e-05 3.37e-04 0.32000 -3.05e-01 -9.70e-02 2.96e-04 2.50e-01
Activation of RAC1 downstream of NMDARs 7 4.45e-01 5.83e-01 0.32000 -2.52e-01 1.98e-01 2.49e-01 3.64e-01
Activation of AMPK downstream of NMDARs 20 7.73e-02 1.68e-01 0.32000 -1.35e-01 2.90e-01 2.97e-01 2.48e-02
Synaptic adhesion-like molecules 17 1.27e-01 2.43e-01 0.31900 2.76e-01 -1.61e-01 4.90e-02 2.51e-01
Na+/Cl- dependent neurotransmitter transporters 8 1.64e-01 2.87e-01 0.31900 1.63e-01 2.74e-01 4.26e-01 1.79e-01
S Phase 150 4.76e-12 9.49e-11 0.31800 -3.18e-01 -6.34e-03 1.77e-11 8.93e-01
Serotonin Neurotransmitter Release Cycle 15 1.72e-01 2.97e-01 0.31600 1.67e-01 -2.68e-01 2.63e-01 7.20e-02
Processing of Capped Intronless Pre-mRNA 29 8.17e-03 2.86e-02 0.31500 -3.15e-01 8.46e-03 3.34e-03 9.37e-01
Translation of Structural Proteins 9694635 56 2.09e-03 8.99e-03 0.31500 -2.26e-01 2.19e-01 3.37e-03 4.62e-03
RIP-mediated NFkB activation via ZBP1 17 1.54e-01 2.75e-01 0.31500 2.26e-01 -2.19e-01 1.07e-01 1.18e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 4.98e-02 1.20e-01 0.31400 -2.78e-01 1.47e-01 1.62e-02 2.02e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 1.08e-07 1.04e-06 0.31400 -2.12e-01 2.31e-01 8.79e-06 1.34e-06
Nuclear Envelope (NE) Reassembly 68 2.21e-04 1.20e-03 0.31300 -2.86e-01 1.27e-01 4.46e-05 7.08e-02
Downstream signaling events of B Cell Receptor (BCR) 68 2.06e-04 1.14e-03 0.31300 -2.88e-01 1.22e-01 4.01e-05 8.31e-02
Metabolism of non-coding RNA 53 1.25e-05 8.78e-05 0.31200 -2.76e-01 -1.45e-01 4.97e-04 6.85e-02
snRNP Assembly 53 1.25e-05 8.78e-05 0.31200 -2.76e-01 -1.45e-01 4.97e-04 6.85e-02
HIV Infection 213 4.28e-15 1.20e-13 0.31100 -3.10e-01 2.38e-02 5.48e-15 5.50e-01
Activation of Ca-permeable Kainate Receptor 9 1.58e-01 2.80e-01 0.31100 2.88e-01 1.17e-01 1.34e-01 5.44e-01
Ionotropic activity of kainate receptors 9 1.58e-01 2.80e-01 0.31100 2.88e-01 1.17e-01 1.34e-01 5.44e-01
Protein ubiquitination 71 2.45e-04 1.32e-03 0.31000 -2.75e-01 1.43e-01 6.05e-05 3.75e-02
Golgi Associated Vesicle Biogenesis 55 2.84e-03 1.17e-02 0.31000 -2.20e-01 2.18e-01 4.78e-03 5.12e-03
Metabolism of nitric oxide: NOS3 activation and regulation 15 1.28e-01 2.44e-01 0.30900 -3.00e-01 7.35e-02 4.40e-02 6.22e-01
H139Hfs13* PPM1K causes a mild variant of MSUD 5 5.88e-01 7.00e-01 0.30900 -2.23e-01 2.14e-01 3.89e-01 4.07e-01
Maple Syrup Urine Disease 5 5.88e-01 7.00e-01 0.30900 -2.23e-01 2.14e-01 3.89e-01 4.07e-01
Protein folding 83 6.93e-05 4.22e-04 0.30800 -2.73e-01 1.42e-01 1.67e-05 2.54e-02
TNFR1-induced proapoptotic signaling 24 7.53e-02 1.65e-01 0.30700 2.48e-01 -1.81e-01 3.53e-02 1.24e-01
Heme biosynthesis 13 8.17e-02 1.76e-01 0.30700 -9.12e-02 -2.94e-01 5.69e-01 6.69e-02
Calnexin/calreticulin cycle 26 6.12e-02 1.41e-01 0.30700 -2.47e-01 1.83e-01 2.93e-02 1.06e-01
Transcriptional regulation of pluripotent stem cells 21 1.65e-02 5.05e-02 0.30700 2.90e-01 1.01e-01 2.13e-02 4.24e-01
Autophagy 142 5.56e-08 5.65e-07 0.30700 -2.79e-01 1.29e-01 9.68e-09 7.87e-03
ZBP1(DAI) mediated induction of type I IFNs 20 1.20e-01 2.34e-01 0.30700 2.39e-01 -1.93e-01 6.44e-02 1.36e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 6.28e-03 2.29e-02 0.30700 -2.37e-01 1.95e-01 4.54e-03 1.93e-02
Negative regulation of FGFR4 signaling 22 9.99e-02 2.03e-01 0.30700 -2.13e-01 2.21e-01 8.41e-02 7.28e-02
Host Interactions of HIV factors 118 1.61e-08 1.76e-07 0.30700 -3.06e-01 2.11e-02 9.28e-09 6.93e-01
Recycling pathway of L1 40 1.52e-02 4.74e-02 0.30700 -2.10e-01 2.23e-01 2.14e-02 1.46e-02
Beta-oxidation of pristanoyl-CoA 9 1.85e-01 3.13e-01 0.30600 -2.96e-01 -7.88e-02 1.24e-01 6.82e-01
NFE2L2 regulating MDR associated enzymes 8 1.80e-01 3.05e-01 0.30600 2.31e-01 2.01e-01 2.58e-01 3.26e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 2.16e-01 3.49e-01 0.30600 -3.04e-01 -3.01e-02 1.14e-01 8.76e-01
Germ layer formation at gastrulation 9 2.04e-01 3.35e-01 0.30600 3.02e-01 4.76e-02 1.17e-01 8.05e-01
trans-Golgi Network Vesicle Budding 69 5.86e-04 2.89e-03 0.30600 -2.54e-01 1.71e-01 2.67e-04 1.43e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 6.82e-02 1.52e-01 0.30600 -3.06e-01 3.39e-03 2.91e-02 9.81e-01
Nucleotide catabolism 28 2.32e-02 6.66e-02 0.30500 -2.97e-01 6.91e-02 6.45e-03 5.27e-01
HSF1 activation 26 4.09e-03 1.62e-02 0.30500 -2.44e-01 -1.83e-01 3.13e-02 1.06e-01
SARS-CoV-1 Infection 138 4.27e-10 6.07e-09 0.30500 -3.05e-01 4.40e-03 6.00e-10 9.29e-01
ADP signalling through P2Y purinoceptor 12 18 1.34e-01 2.50e-01 0.30300 -1.42e-01 2.68e-01 2.98e-01 4.89e-02
HCMV Late Events 67 2.52e-04 1.35e-03 0.30300 -2.88e-01 9.57e-02 4.69e-05 1.75e-01
Cell-extracellular matrix interactions 16 1.92e-01 3.21e-01 0.30300 -1.89e-01 2.36e-01 1.91e-01 1.01e-01
O-glycosylation of TSR domain-containing proteins 28 1.53e-02 4.76e-02 0.30200 3.02e-01 -1.73e-02 5.74e-03 8.74e-01
Formation of paraxial mesoderm 52 1.77e-03 7.74e-03 0.30200 -2.85e-01 9.77e-02 3.72e-04 2.23e-01
Platelet activation, signaling and aggregation 223 1.65e-10 2.50e-09 0.30200 -1.95e-01 2.30e-01 4.90e-07 3.39e-09
Glycogen breakdown (glycogenolysis) 12 1.33e-01 2.50e-01 0.30100 3.83e-02 2.98e-01 8.18e-01 7.34e-02
Antimicrobial peptides 34 1.78e-02 5.38e-02 0.30100 -1.07e-01 2.81e-01 2.79e-01 4.56e-03
Ca2+ activated K+ channels 6 5.36e-01 6.63e-01 0.29900 -2.50e-01 1.65e-01 2.90e-01 4.83e-01
KEAP1-NFE2L2 pathway 107 1.43e-05 9.92e-05 0.29900 -2.53e-01 1.59e-01 6.10e-06 4.44e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.01e-01 3.31e-01 0.29900 -2.31e-01 1.90e-01 1.10e-01 1.89e-01
Synthesis of PC 23 9.30e-02 1.92e-01 0.29800 -1.64e-01 2.49e-01 1.73e-01 3.86e-02
Defective B3GALTL causes PpS 27 1.72e-02 5.21e-02 0.29800 2.98e-01 -1.90e-03 7.37e-03 9.86e-01
Transcriptional regulation of testis differentiation 5 5.40e-01 6.66e-01 0.29800 2.86e-01 -8.30e-02 2.68e-01 7.48e-01
Other interleukin signaling 19 1.49e-01 2.70e-01 0.29800 1.85e-01 -2.33e-01 1.63e-01 7.81e-02
Regulation of innate immune responses to cytosolic DNA 14 8.26e-02 1.77e-01 0.29800 -2.87e-01 -7.98e-02 6.31e-02 6.05e-01
mTORC1-mediated signalling 24 5.72e-02 1.33e-01 0.29800 -2.82e-01 9.47e-02 1.67e-02 4.22e-01
E2F-enabled inhibition of pre-replication complex formation 9 3.19e-01 4.61e-01 0.29700 -2.89e-01 6.75e-02 1.33e-01 7.26e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 5.27e-01 6.54e-01 0.29600 -2.63e-01 1.36e-01 2.65e-01 5.64e-01
CASP8 activity is inhibited 11 3.28e-01 4.69e-01 0.29500 2.48e-01 -1.60e-01 1.55e-01 3.57e-01
Dimerization of procaspase-8 11 3.28e-01 4.69e-01 0.29500 2.48e-01 -1.60e-01 1.55e-01 3.57e-01
Regulation by c-FLIP 11 3.28e-01 4.69e-01 0.29500 2.48e-01 -1.60e-01 1.55e-01 3.57e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 5.47e-02 1.30e-01 0.29500 -2.20e-01 1.96e-01 3.67e-02 6.37e-02
Cell-cell junction organization 60 2.78e-03 1.15e-02 0.29400 2.34e-01 -1.78e-01 1.68e-03 1.72e-02
Reversal of alkylation damage by DNA dioxygenases 7 3.67e-01 5.08e-01 0.29400 -2.93e-01 1.04e-02 1.79e-01 9.62e-01
Activation of caspases through apoptosome-mediated cleavage 6 3.84e-01 5.27e-01 0.29400 -2.91e-01 -3.69e-02 2.17e-01 8.76e-01
Defects in vitamin and cofactor metabolism 21 1.86e-02 5.52e-02 0.29300 -1.41e-01 -2.57e-01 2.63e-01 4.13e-02
ARMS-mediated activation 6 3.71e-01 5.12e-01 0.29300 5.45e-02 2.88e-01 8.17e-01 2.21e-01
Phase 2 - plateau phase 11 3.49e-01 4.92e-01 0.29300 2.03e-01 -2.12e-01 2.44e-01 2.24e-01
Assembly Of The HIV Virion 15 1.76e-01 3.00e-01 0.29300 -2.78e-01 9.23e-02 6.21e-02 5.36e-01
Nuclear events stimulated by ALK signaling in cancer 33 4.14e-02 1.04e-01 0.29300 1.86e-01 -2.27e-01 6.45e-02 2.43e-02
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 4.68e-01 6.03e-01 0.29300 5.82e-02 -2.87e-01 8.05e-01 2.23e-01
Regulation of BACH1 activity 11 2.25e-01 3.61e-01 0.29300 -2.91e-01 3.08e-02 9.44e-02 8.60e-01
Diseases associated with the TLR signaling cascade 29 4.39e-02 1.09e-01 0.29300 2.67e-01 -1.21e-01 1.30e-02 2.59e-01
Diseases of Immune System 29 4.39e-02 1.09e-01 0.29300 2.67e-01 -1.21e-01 1.30e-02 2.59e-01
Antigen processing-Cross presentation 89 4.96e-05 3.17e-04 0.29300 -2.73e-01 1.06e-01 8.68e-06 8.35e-02
MyD88 deficiency (TLR2/4) 14 1.89e-01 3.18e-01 0.29200 2.81e-01 -8.07e-02 6.87e-02 6.01e-01
Regulation of PTEN mRNA translation 13 2.12e-01 3.44e-01 0.29200 2.81e-01 -7.80e-02 7.90e-02 6.26e-01
Common Pathway of Fibrin Clot Formation 13 1.37e-01 2.53e-01 0.29200 2.34e-02 2.91e-01 8.84e-01 6.94e-02
Basigin interactions 23 1.12e-01 2.22e-01 0.29100 -2.27e-01 1.81e-01 5.94e-02 1.32e-01
Defective Intrinsic Pathway for Apoptosis 24 6.90e-02 1.54e-01 0.29000 -2.73e-01 9.98e-02 2.08e-02 3.97e-01
TRP channels 22 8.21e-02 1.76e-01 0.29000 2.75e-01 -9.15e-02 2.54e-02 4.58e-01
Activation of RAS in B cells 5 5.44e-01 6.68e-01 0.29000 2.83e-01 -6.44e-02 2.74e-01 8.03e-01
IRE1alpha activates chaperones 46 1.17e-02 3.86e-02 0.28900 -1.62e-01 2.40e-01 5.76e-02 4.88e-03
Regulation of FOXO transcriptional activity by acetylation 10 1.75e-01 3.00e-01 0.28900 9.95e-02 2.72e-01 5.86e-01 1.37e-01
CLEC7A/inflammasome pathway 6 5.72e-01 6.87e-01 0.28900 2.08e-01 -2.01e-01 3.78e-01 3.94e-01
Role of second messengers in netrin-1 signaling 6 5.62e-01 6.80e-01 0.28900 2.39e-01 -1.62e-01 3.12e-01 4.91e-01
Linoleic acid (LA) metabolism 7 5.18e-01 6.46e-01 0.28900 2.26e-01 -1.80e-01 3.01e-01 4.10e-01
Gluconeogenesis 19 2.74e-02 7.66e-02 0.28800 -2.29e-01 -1.75e-01 8.33e-02 1.87e-01
Voltage gated Potassium channels 26 4.96e-02 1.20e-01 0.28800 2.77e-01 -7.83e-02 1.45e-02 4.90e-01
PI-3K cascade:FGFR4 11 1.32e-01 2.48e-01 0.28800 2.47e-01 1.48e-01 1.56e-01 3.97e-01
Acetylcholine binding and downstream events 5 4.42e-01 5.82e-01 0.28800 2.80e-01 6.73e-02 2.79e-01 7.94e-01
Postsynaptic nicotinic acetylcholine receptors 5 4.42e-01 5.82e-01 0.28800 2.80e-01 6.73e-02 2.79e-01 7.94e-01
Interaction between L1 and Ankyrins 26 4.11e-02 1.03e-01 0.28700 2.82e-01 -5.22e-02 1.28e-02 6.45e-01
MECP2 regulates neuronal receptors and channels 14 2.21e-01 3.55e-01 0.28700 2.68e-01 -1.02e-01 8.23e-02 5.10e-01
Viral Infection Pathways 776 7.86e-41 5.43e-39 0.28600 -2.82e-01 5.10e-02 7.76e-41 1.56e-02
Transcriptional regulation by small RNAs 61 5.03e-04 2.49e-03 0.28600 -2.83e-01 4.34e-02 1.35e-04 5.57e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.80e-01 3.05e-01 0.28500 -2.81e-01 4.84e-02 6.87e-02 7.54e-01
Degradation of beta-catenin by the destruction complex 72 4.42e-04 2.24e-03 0.28500 -2.68e-01 9.78e-02 8.50e-05 1.51e-01
Membrane binding and targetting of GAG proteins 13 1.68e-01 2.91e-01 0.28500 -2.85e-01 3.48e-03 7.51e-02 9.83e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 1.68e-01 2.91e-01 0.28500 -2.85e-01 3.48e-03 7.51e-02 9.83e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.30e-02 8.88e-02 0.28500 2.85e-01 -5.11e-03 1.37e-02 9.65e-01
RHOBTB GTPase Cycle 35 3.71e-02 9.74e-02 0.28400 -2.40e-01 1.52e-01 1.42e-02 1.19e-01
Late Phase of HIV Life Cycle 131 1.62e-08 1.76e-07 0.28400 -2.84e-01 -7.76e-04 2.00e-08 9.88e-01
Cellular responses to stress 698 1.75e-34 8.89e-33 0.28400 -2.75e-01 6.93e-02 2.47e-35 1.81e-03
Purine salvage 12 1.10e-01 2.20e-01 0.28300 -2.14e-01 -1.86e-01 2.00e-01 2.65e-01
Phase II - Conjugation of compounds 71 4.99e-04 2.48e-03 0.28300 -2.68e-01 9.23e-02 9.63e-05 1.79e-01
HIV Life Cycle 144 9.66e-10 1.30e-08 0.28300 -2.82e-01 -2.60e-02 5.41e-09 5.90e-01
Butyrophilin (BTN) family interactions 9 3.86e-01 5.29e-01 0.28300 9.62e-02 -2.66e-01 6.17e-01 1.67e-01
The phototransduction cascade 26 9.04e-02 1.89e-01 0.28200 -1.56e-01 2.35e-01 1.68e-01 3.77e-02
Chondroitin sulfate biosynthesis 12 1.22e-01 2.35e-01 0.28200 2.48e-01 1.35e-01 1.37e-01 4.19e-01
IFNG signaling activates MAPKs 8 3.57e-01 4.99e-01 0.28200 -2.14e-02 2.82e-01 9.16e-01 1.68e-01
Signaling by high-kinase activity BRAF mutants 33 4.90e-02 1.19e-01 0.28200 -2.31e-01 1.63e-01 2.17e-02 1.06e-01
Cholesterol biosynthesis 26 4.02e-02 1.03e-01 0.28200 -2.80e-01 3.55e-02 1.36e-02 7.54e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 1.57e-01 2.79e-01 0.28200 -1.92e-01 2.06e-01 1.28e-01 1.02e-01
MAP2K and MAPK activation 36 3.56e-02 9.37e-02 0.28100 -2.38e-01 1.50e-01 1.34e-02 1.19e-01
Non-integrin membrane-ECM interactions 51 2.68e-03 1.12e-02 0.28100 -5.69e-02 2.75e-01 4.82e-01 6.65e-04
mRNA 3’-end processing 57 8.30e-04 3.96e-03 0.27900 -2.78e-01 2.53e-02 2.79e-04 7.41e-01
Suppression of phagosomal maturation 12 2.98e-01 4.41e-01 0.27900 -2.59e-01 1.04e-01 1.20e-01 5.32e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.66e-01 4.08e-01 0.27900 -2.47e-01 1.30e-01 1.10e-01 3.98e-01
Signaling by NODAL 15 2.49e-01 3.89e-01 0.27900 -1.40e-01 2.41e-01 3.48e-01 1.06e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 4.24e-03 1.66e-02 0.27900 2.78e-01 -2.50e-02 1.43e-03 7.74e-01
CLEC7A (Dectin-1) induces NFAT activation 11 3.33e-01 4.74e-01 0.27900 2.58e-01 -1.07e-01 1.39e-01 5.40e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.24e-01 2.39e-01 0.27800 -2.35e-01 1.48e-01 5.06e-02 2.18e-01
Prostacyclin signalling through prostacyclin receptor 16 2.47e-01 3.87e-01 0.27800 -2.18e-01 1.73e-01 1.31e-01 2.32e-01
Processing of DNA double-strand break ends 69 4.61e-04 2.33e-03 0.27800 -2.71e-01 6.25e-02 1.00e-04 3.69e-01
Transport of vitamins, nucleosides, and related molecules 32 2.31e-02 6.64e-02 0.27800 -2.75e-01 4.19e-02 7.18e-03 6.82e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.15e-02 1.76e-01 0.27700 -2.77e-01 1.74e-02 3.21e-02 8.93e-01
Chaperonin-mediated protein folding 77 8.20e-04 3.92e-03 0.27700 -2.43e-01 1.33e-01 2.28e-04 4.32e-02
Interleukin-23 signaling 7 5.49e-01 6.71e-01 0.27700 2.07e-01 -1.84e-01 3.43e-01 3.99e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 5 4.18e-01 5.60e-01 0.27600 1.77e-01 2.12e-01 4.93e-01 4.12e-01
TRAIL signaling 8 3.63e-01 5.05e-01 0.27600 2.76e-01 -1.07e-02 1.76e-01 9.58e-01
Dermatan sulfate biosynthesis 6 5.52e-01 6.74e-01 0.27600 -1.02e-01 2.57e-01 6.66e-01 2.76e-01
XBP1(S) activates chaperone genes 44 2.37e-02 6.79e-02 0.27600 -1.78e-01 2.10e-01 4.06e-02 1.59e-02
Integrin signaling 22 1.43e-01 2.61e-01 0.27500 -1.49e-01 2.31e-01 2.25e-01 6.04e-02
G alpha (z) signalling events 36 8.55e-03 2.97e-02 0.27500 1.07e-02 2.75e-01 9.12e-01 4.32e-03
Transcriptional Regulation by NPAS4 27 4.07e-02 1.03e-01 0.27500 2.73e-01 -3.16e-02 1.40e-02 7.76e-01
Late SARS-CoV-2 Infection Events 64 4.66e-03 1.79e-02 0.27500 -1.97e-01 1.91e-01 6.34e-03 8.10e-03
Glyoxylate metabolism and glycine degradation 13 2.57e-01 3.98e-01 0.27400 -2.63e-01 7.45e-02 1.00e-01 6.42e-01
Response of Mtb to phagocytosis 22 1.62e-01 2.84e-01 0.27300 -1.95e-01 1.91e-01 1.14e-01 1.21e-01
HCMV Infection 106 2.28e-05 1.55e-04 0.27200 -2.60e-01 8.17e-02 3.81e-06 1.46e-01
Cytosolic sulfonation of small molecules 18 2.24e-01 3.60e-01 0.27200 -1.71e-01 2.11e-01 2.08e-01 1.22e-01
Cobalamin (Cbl) metabolism 7 4.28e-01 5.70e-01 0.27200 1.40e-02 -2.71e-01 9.49e-01 2.14e-01
SHC1 events in ERBB4 signaling 10 4.15e-01 5.59e-01 0.27200 2.35e-01 -1.36e-01 1.98e-01 4.57e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 4.55e-01 5.90e-01 0.27100 2.56e-01 -8.91e-02 2.09e-01 6.63e-01
Glycogen storage diseases 13 3.46e-01 4.89e-01 0.27100 -1.94e-01 1.89e-01 2.25e-01 2.38e-01
Defective C1GALT1C1 causes TNPS 10 3.14e-01 4.55e-01 0.27000 2.69e-01 -2.76e-02 1.41e-01 8.80e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 3.52e-06 2.69e-05 0.27000 -2.69e-01 8.25e-03 2.05e-06 8.84e-01
EGFR interacts with phospholipase C-gamma 7 4.38e-01 5.79e-01 0.26900 2.69e-01 -1.78e-02 2.18e-01 9.35e-01
Reelin signalling pathway 5 4.88e-01 6.18e-01 0.26900 6.51e-02 2.61e-01 8.01e-01 3.12e-01
Repression of WNT target genes 14 3.21e-01 4.63e-01 0.26900 2.04e-01 -1.75e-01 1.85e-01 2.57e-01
Formation of apoptosome 11 3.04e-01 4.46e-01 0.26900 -2.65e-01 4.78e-02 1.29e-01 7.84e-01
Regulation of the apoptosome activity 11 3.04e-01 4.46e-01 0.26900 -2.65e-01 4.78e-02 1.29e-01 7.84e-01
Phosphorylation of Emi1 6 5.60e-01 6.79e-01 0.26900 -2.54e-01 8.83e-02 2.82e-01 7.08e-01
Regulation of beta-cell development 22 6.38e-02 1.45e-01 0.26900 2.69e-01 6.82e-03 2.92e-02 9.56e-01
tRNA processing in the nucleus 59 1.54e-04 8.67e-04 0.26800 -2.53e-01 -8.85e-02 7.71e-04 2.40e-01
Cellular responses to stimuli 779 7.72e-33 3.83e-31 0.26800 -2.56e-01 8.05e-02 5.48e-34 1.32e-04
Methylation 13 2.91e-01 4.35e-01 0.26800 -2.52e-01 9.14e-02 1.16e-01 5.68e-01
G2/M DNA damage checkpoint 66 2.49e-03 1.05e-02 0.26800 -2.45e-01 1.07e-01 5.67e-04 1.31e-01
Metabolism of porphyrins 23 3.51e-02 9.27e-02 0.26800 -2.56e-01 -7.84e-02 3.37e-02 5.15e-01
Synthesis of PG 8 4.53e-01 5.89e-01 0.26800 7.53e-02 -2.57e-01 7.12e-01 2.09e-01
TRAF6 mediated IRF7 activation 15 2.95e-01 4.38e-01 0.26700 2.14e-01 -1.60e-01 1.51e-01 2.83e-01
GAB1 signalosome 15 9.00e-02 1.89e-01 0.26700 2.23e-01 1.47e-01 1.35e-01 3.23e-01
Maternal to zygotic transition (MZT) 72 1.92e-03 8.31e-03 0.26700 -1.21e-01 2.37e-01 7.51e-02 4.93e-04
Reversible hydration of carbon dioxide 8 2.74e-01 4.18e-01 0.26700 1.65e-01 2.09e-01 4.18e-01 3.06e-01
TP53 Regulates Metabolic Genes 78 1.47e-03 6.60e-03 0.26600 -2.28e-01 1.37e-01 4.87e-04 3.68e-02
Diseases of carbohydrate metabolism 29 8.02e-02 1.74e-01 0.26600 -2.38e-01 1.19e-01 2.66e-02 2.69e-01
Synthesis of PIPs at the plasma membrane 52 3.03e-03 1.25e-02 0.26600 2.64e-01 -2.78e-02 9.75e-04 7.29e-01
Regulation of TP53 Activity through Association with Co-factors 13 3.57e-01 4.99e-01 0.26500 2.06e-01 -1.67e-01 1.98e-01 2.99e-01
Homology Directed Repair 110 1.16e-06 9.36e-06 0.26500 -2.64e-01 -1.68e-02 1.67e-06 7.61e-01
Vitamin B2 (riboflavin) metabolism 6 4.25e-01 5.68e-01 0.26500 -7.75e-02 -2.53e-01 7.42e-01 2.83e-01
IRAK4 deficiency (TLR2/4) 15 2.25e-01 3.60e-01 0.26400 2.56e-01 -6.48e-02 8.55e-02 6.64e-01
TRIF-mediated programmed cell death 9 4.97e-01 6.26e-01 0.26400 1.88e-01 -1.85e-01 3.28e-01 3.36e-01
Diseases associated with O-glycosylation of proteins 50 1.12e-02 3.73e-02 0.26400 2.44e-01 -9.99e-02 2.79e-03 2.22e-01
Pyrimidine catabolism 9 4.97e-01 6.26e-01 0.26300 -2.00e-01 1.71e-01 2.98e-01 3.75e-01
Interleukin-37 signaling 19 5.87e-02 1.36e-01 0.26300 2.38e-01 1.11e-01 7.21e-02 4.01e-01
PTK6 promotes HIF1A stabilization 6 4.36e-01 5.78e-01 0.26300 2.54e-01 6.81e-02 2.82e-01 7.73e-01
RHO GTPases Activate ROCKs 18 1.34e-01 2.50e-01 0.26300 -1.94e-02 2.62e-01 8.86e-01 5.42e-02
Lysosphingolipid and LPA receptors 11 4.10e-01 5.54e-01 0.26300 2.24e-01 -1.38e-01 1.99e-01 4.29e-01
EGFR downregulation 27 7.06e-02 1.56e-01 0.26300 -6.41e-02 2.55e-01 5.64e-01 2.20e-02
Phase 3 - rapid repolarisation 6 5.49e-01 6.71e-01 0.26300 5.77e-02 -2.56e-01 8.07e-01 2.77e-01
Metabolism of proteins 1777 4.35e-73 2.80e-70 0.26200 -2.57e-01 5.32e-02 7.43e-73 1.96e-04
Leishmania infection 211 1.07e-07 1.04e-06 0.26200 -1.75e-01 1.95e-01 1.15e-05 1.04e-06
Parasitic Infection Pathways 211 1.07e-07 1.04e-06 0.26200 -1.75e-01 1.95e-01 1.15e-05 1.04e-06
Regulation of TLR by endogenous ligand 15 2.88e-01 4.32e-01 0.26100 1.23e-01 -2.31e-01 4.11e-01 1.22e-01
Other semaphorin interactions 16 8.36e-02 1.79e-01 0.26100 2.09e-01 1.57e-01 1.49e-01 2.76e-01
MAPK6/MAPK4 signaling 69 1.58e-03 7.00e-03 0.26100 -2.50e-01 7.61e-02 3.32e-04 2.74e-01
Signaling by ERBB2 KD Mutants 20 1.49e-01 2.68e-01 0.26100 2.51e-01 -6.91e-02 5.15e-02 5.92e-01
p75NTR signals via NF-kB 15 2.64e-01 4.07e-01 0.26100 -2.43e-01 9.41e-02 1.03e-01 5.28e-01
G beta:gamma signalling through BTK 15 3.11e-01 4.52e-01 0.26000 -1.48e-01 2.14e-01 3.21e-01 1.51e-01
SOS-mediated signalling 7 4.04e-01 5.49e-01 0.26000 4.64e-02 2.56e-01 8.32e-01 2.41e-01
Protein-protein interactions at synapses 61 8.60e-03 2.98e-02 0.26000 2.16e-01 -1.45e-01 3.57e-03 5.02e-02
Metabolic disorders of biological oxidation enzymes 26 1.42e-01 2.60e-01 0.25900 -1.69e-01 1.96e-01 1.36e-01 8.29e-02
RNA Polymerase I Transcription Initiation 47 1.15e-03 5.35e-03 0.25900 -2.35e-01 -1.08e-01 5.28e-03 2.01e-01
Downstream signaling of activated FGFR1 22 3.98e-02 1.02e-01 0.25900 2.29e-01 1.20e-01 6.26e-02 3.31e-01
Transcriptional regulation of granulopoiesis 44 3.05e-02 8.29e-02 0.25800 -1.28e-01 2.24e-01 1.42e-01 1.02e-02
Mitotic Spindle Checkpoint 108 9.25e-05 5.46e-04 0.25800 -2.40e-01 9.42e-02 1.67e-05 9.07e-02
Transcriptional regulation by RUNX2 92 1.45e-04 8.24e-04 0.25800 -2.51e-01 5.59e-02 3.06e-05 3.54e-01
Association of TriC/CCT with target proteins during biosynthesis 35 2.85e-02 7.91e-02 0.25700 -2.55e-01 3.70e-02 9.12e-03 7.05e-01
HDR through Homologous Recombination (HRR) 68 1.22e-04 7.03e-04 0.25700 -2.48e-01 -6.83e-02 4.04e-04 3.30e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.42e-01 2.60e-01 0.25700 2.37e-01 9.72e-02 1.24e-01 5.29e-01
RHO GTPases Activate WASPs and WAVEs 35 7.70e-02 1.68e-01 0.25700 -1.75e-01 1.87e-01 7.29e-02 5.50e-02
Signaling by NTRK3 (TRKC) 16 2.43e-01 3.82e-01 0.25600 2.43e-01 -8.23e-02 9.27e-02 5.69e-01
MicroRNA (miRNA) biogenesis 24 1.00e-01 2.03e-01 0.25600 -2.50e-01 5.34e-02 3.37e-02 6.51e-01
Regulation of signaling by CBL 22 9.06e-02 1.89e-01 0.25600 2.56e-01 -8.26e-03 3.77e-02 9.47e-01
MET promotes cell motility 33 4.72e-02 1.15e-01 0.25600 -6.41e-02 2.47e-01 5.24e-01 1.39e-02
Regulation of HMOX1 expression and activity 5 6.58e-01 7.65e-01 0.25600 2.36e-01 -9.89e-02 3.61e-01 7.02e-01
SUMOylation of DNA methylation proteins 16 9.12e-02 1.90e-01 0.25500 -1.89e-01 -1.72e-01 1.91e-01 2.34e-01
MET activates RAS signaling 10 2.29e-01 3.64e-01 0.25500 2.08e-01 1.48e-01 2.55e-01 4.18e-01
RHOJ GTPase cycle 50 7.35e-03 2.60e-02 0.25500 -4.23e-02 2.52e-01 6.04e-01 2.07e-03
Hyaluronan uptake and degradation 12 3.79e-01 5.22e-01 0.25500 -2.30e-01 1.11e-01 1.68e-01 5.06e-01
CHL1 interactions 8 4.79e-01 6.11e-01 0.25500 -6.52e-02 2.47e-01 7.49e-01 2.27e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 7.30e-02 1.60e-01 0.25500 2.41e-01 -8.18e-02 2.22e-02 4.38e-01
Thyroxine biosynthesis 5 6.53e-01 7.60e-01 0.25500 2.38e-01 -8.98e-02 3.56e-01 7.28e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.99e-01 3.29e-01 0.25500 -2.19e-01 1.30e-01 8.23e-02 3.03e-01
Synthesis of PIPs at the early endosome membrane 16 2.84e-01 4.26e-01 0.25400 2.25e-01 -1.18e-01 1.19e-01 4.12e-01
PI-3K cascade:FGFR2 13 1.75e-01 3.00e-01 0.25400 2.40e-01 8.35e-02 1.34e-01 6.02e-01
Class B/2 (Secretin family receptors) 55 9.27e-03 3.17e-02 0.25400 2.38e-01 -8.79e-02 2.22e-03 2.60e-01
Formation of axial mesoderm 6 4.87e-01 6.18e-01 0.25300 2.51e-01 3.56e-02 2.87e-01 8.80e-01
Negative regulation of FGFR2 signaling 24 1.80e-01 3.05e-01 0.25300 -1.78e-01 1.80e-01 1.31e-01 1.27e-01
Golgi-to-ER retrograde transport 123 1.54e-04 8.67e-04 0.25300 -1.91e-01 1.67e-01 2.59e-04 1.42e-03
Intrinsic Pathway for Apoptosis 54 1.27e-02 4.12e-02 0.25300 -2.31e-01 1.03e-01 3.31e-03 1.88e-01
Unwinding of DNA 12 2.04e-01 3.35e-01 0.25200 -2.37e-01 -8.55e-02 1.55e-01 6.08e-01
Vpr-mediated nuclear import of PICs 34 1.39e-02 4.44e-02 0.25200 -6.05e-02 -2.45e-01 5.42e-01 1.35e-02
Downstream signaling of activated FGFR3 17 9.20e-02 1.91e-01 0.25100 2.16e-01 1.28e-01 1.23e-01 3.59e-01
RHOBTB3 ATPase cycle 10 4.65e-01 6.00e-01 0.25100 -2.22e-01 1.16e-01 2.24e-01 5.24e-01
Mitotic G2-G2/M phases 179 4.61e-08 4.80e-07 0.25000 -2.47e-01 4.04e-02 1.17e-08 3.51e-01
GABA receptor activation 38 5.40e-03 2.03e-02 0.25000 2.21e-01 1.17e-01 1.83e-02 2.11e-01
PI Metabolism 79 1.51e-03 6.75e-03 0.25000 2.34e-01 -8.78e-02 3.15e-04 1.77e-01
NCAM1 interactions 27 8.78e-02 1.85e-01 0.25000 2.44e-01 -5.75e-02 2.85e-02 6.05e-01
TNFR2 non-canonical NF-kB pathway 84 7.95e-05 4.82e-04 0.25000 -2.49e-01 -2.04e-02 7.78e-05 7.46e-01
Activation of ATR in response to replication stress 37 1.40e-02 4.44e-02 0.25000 -2.48e-01 -3.10e-02 9.07e-03 7.44e-01
PLC beta mediated events 40 6.09e-02 1.41e-01 0.25000 1.93e-01 -1.59e-01 3.49e-02 8.24e-02
Nucleotide salvage 21 9.10e-02 1.90e-01 0.25000 -2.48e-01 -2.74e-02 4.91e-02 8.28e-01
RMTs methylate histone arginines 35 2.47e-02 7.05e-02 0.24900 -2.49e-01 1.01e-03 1.06e-02 9.92e-01
G1/S-Specific Transcription 29 6.11e-02 1.41e-01 0.24900 -2.47e-01 3.26e-02 2.12e-02 7.61e-01
DNA Repair 289 3.80e-16 1.21e-14 0.24900 -2.41e-01 -6.39e-02 1.72e-12 6.18e-02
Nephrin family interactions 20 7.62e-02 1.67e-01 0.24900 2.36e-01 8.18e-02 6.82e-02 5.27e-01
Cardiogenesis 16 3.05e-01 4.46e-01 0.24800 1.18e-01 -2.18e-01 4.13e-01 1.31e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 5.65e-02 1.32e-01 0.24700 -2.02e-01 1.43e-01 2.53e-02 1.13e-01
Signaling by RAS mutants 41 5.65e-02 1.32e-01 0.24700 -2.02e-01 1.43e-01 2.53e-02 1.13e-01
Signaling by moderate kinase activity BRAF mutants 41 5.65e-02 1.32e-01 0.24700 -2.02e-01 1.43e-01 2.53e-02 1.13e-01
Signaling downstream of RAS mutants 41 5.65e-02 1.32e-01 0.24700 -2.02e-01 1.43e-01 2.53e-02 1.13e-01
Infectious disease 959 1.93e-35 1.01e-33 0.24700 -2.39e-01 5.98e-02 2.86e-36 1.71e-03
TLR3-mediated TICAM1-dependent programmed cell death 6 6.67e-01 7.72e-01 0.24600 1.63e-01 -1.84e-01 4.89e-01 4.35e-01
Defensins 8 5.82e-01 6.95e-01 0.24600 -1.60e-01 1.87e-01 4.35e-01 3.59e-01
Plasma lipoprotein remodeling 18 2.87e-01 4.31e-01 0.24600 -1.42e-01 2.01e-01 2.98e-01 1.40e-01
Amino acid transport across the plasma membrane 26 1.50e-01 2.70e-01 0.24600 -1.16e-01 2.17e-01 3.07e-01 5.59e-02
Meiosis 67 5.01e-03 1.91e-02 0.24600 -2.30e-01 8.66e-02 1.14e-03 2.20e-01
G2/M Transition 177 7.32e-08 7.28e-07 0.24500 -2.43e-01 3.16e-02 2.34e-08 4.69e-01
Endosomal/Vacuolar pathway 12 3.24e-01 4.66e-01 0.24500 -2.43e-01 2.95e-02 1.44e-01 8.60e-01
Meiotic synapsis 43 4.77e-02 1.16e-01 0.24500 -2.10e-01 1.26e-01 1.73e-02 1.52e-01
Transcriptional Regulation by MECP2 49 2.12e-02 6.19e-02 0.24500 2.29e-01 -8.62e-02 5.52e-03 2.96e-01
Interactions of Vpr with host cellular proteins 37 8.38e-03 2.92e-02 0.24400 -1.05e-01 -2.21e-01 2.67e-01 2.02e-02
Apoptosis 158 8.95e-06 6.43e-05 0.24400 -2.20e-01 1.07e-01 1.85e-06 2.03e-02
Signaling by KIT in disease 20 2.27e-01 3.63e-01 0.24400 2.20e-01 -1.06e-01 8.84e-02 4.11e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.27e-01 3.63e-01 0.24400 2.20e-01 -1.06e-01 8.84e-02 4.11e-01
Norepinephrine Neurotransmitter Release Cycle 14 3.46e-01 4.89e-01 0.24300 9.40e-02 -2.24e-01 5.42e-01 1.46e-01
RNA Polymerase II Pre-transcription Events 77 2.83e-04 1.50e-03 0.24300 -2.42e-01 -2.03e-02 2.39e-04 7.58e-01
Cellular response to chemical stress 179 3.58e-06 2.72e-05 0.24300 -2.11e-01 1.20e-01 1.10e-06 5.52e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 1.74e-02 5.27e-02 0.24300 -1.71e-01 1.72e-01 1.97e-02 1.92e-02
Glutamate Neurotransmitter Release Cycle 20 2.64e-01 4.07e-01 0.24200 1.47e-01 -1.93e-01 2.56e-01 1.36e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.34e-01 2.50e-01 0.24200 1.88e-01 1.53e-01 2.07e-01 3.06e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 1.34e-01 2.50e-01 0.24200 1.88e-01 1.53e-01 2.07e-01 3.06e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 1.34e-01 2.50e-01 0.24200 1.88e-01 1.53e-01 2.07e-01 3.06e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 1.34e-01 2.50e-01 0.24200 1.88e-01 1.53e-01 2.07e-01 3.06e-01
Signaling by CTNNB1 phospho-site mutants 15 1.34e-01 2.50e-01 0.24200 1.88e-01 1.53e-01 2.07e-01 3.06e-01
Signaling by GSK3beta mutants 15 1.34e-01 2.50e-01 0.24200 1.88e-01 1.53e-01 2.07e-01 3.06e-01
Glutamate and glutamine metabolism 12 4.17e-01 5.59e-01 0.24200 -2.19e-01 1.04e-01 1.90e-01 5.33e-01
Pyruvate metabolism 44 2.40e-02 6.85e-02 0.24200 -2.36e-01 5.32e-02 6.74e-03 5.41e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 7 6.31e-01 7.42e-01 0.24200 1.87e-01 -1.53e-01 3.91e-01 4.83e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 1.61e-02 4.95e-02 0.24100 2.40e-01 2.37e-02 9.43e-03 7.98e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 1.47e-01 2.67e-01 0.24100 -1.11e-01 2.14e-01 3.17e-01 5.42e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 1.39e-01 2.56e-01 0.24100 2.25e-01 -8.69e-02 4.72e-02 4.43e-01
Viral Messenger RNA Synthesis 44 3.00e-03 1.24e-02 0.24100 -1.90e-01 -1.48e-01 2.94e-02 8.87e-02
ALK mutants bind TKIs 11 4.81e-01 6.13e-01 0.24100 1.97e-01 -1.39e-01 2.58e-01 4.25e-01
G-protein mediated events 44 5.54e-02 1.31e-01 0.24100 1.92e-01 -1.45e-01 2.72e-02 9.68e-02
M Phase 346 2.19e-12 4.55e-11 0.24100 -2.29e-01 7.36e-02 2.39e-13 1.86e-02
SUMO is proteolytically processed 6 4.61e-01 5.96e-01 0.24000 -2.05e-01 -1.26e-01 3.84e-01 5.94e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 5.45e-01 6.68e-01 0.24000 2.24e-01 8.70e-02 3.86e-01 7.36e-01
Depolymerization of the Nuclear Lamina 15 3.74e-01 5.16e-01 0.24000 -1.43e-01 1.93e-01 3.37e-01 1.96e-01
Downstream signaling of activated FGFR4 18 1.22e-01 2.35e-01 0.24000 2.30e-01 6.91e-02 9.12e-02 6.12e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 5.40e-01 6.66e-01 0.24000 -9.59e-02 -2.20e-01 7.10e-01 3.94e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 5.40e-01 6.66e-01 0.24000 -9.59e-02 -2.20e-01 7.10e-01 3.94e-01
Neddylation 215 1.28e-08 1.42e-07 0.24000 -2.35e-01 4.61e-02 2.66e-09 2.44e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 15 1.48e-01 2.68e-01 0.24000 -1.20e-01 -2.08e-01 4.22e-01 1.64e-01
Deadenylation-dependent mRNA decay 50 5.73e-03 2.14e-02 0.24000 -2.39e-01 -1.98e-02 3.49e-03 8.09e-01
Peroxisomal lipid metabolism 27 4.10e-02 1.03e-01 0.23900 -2.25e-01 -8.00e-02 4.31e-02 4.72e-01
Platelet sensitization by LDL 16 1.35e-01 2.50e-01 0.23900 2.10e-01 1.13e-01 1.46e-01 4.32e-01
Insulin processing 19 2.28e-01 3.64e-01 0.23900 2.28e-01 -7.19e-02 8.59e-02 5.87e-01
Signaling by FGFR3 in disease 14 1.80e-01 3.05e-01 0.23800 2.17e-01 9.96e-02 1.60e-01 5.19e-01
Detoxification of Reactive Oxygen Species 30 5.65e-02 1.32e-01 0.23800 -2.38e-01 3.32e-03 2.39e-02 9.75e-01
Trafficking of GluR2-containing AMPA receptors 11 4.79e-01 6.11e-01 0.23800 -2.04e-01 1.24e-01 2.42e-01 4.77e-01
HCMV Early Events 84 1.34e-03 6.10e-03 0.23800 -2.29e-01 6.54e-02 2.83e-04 3.00e-01
WNT5A-dependent internalization of FZD4 13 3.29e-01 4.71e-01 0.23800 -2.35e-01 4.02e-02 1.43e-01 8.02e-01
P2Y receptors 10 5.32e-01 6.60e-01 0.23800 1.67e-01 -1.70e-01 3.61e-01 3.53e-01
Signaling by RAF1 mutants 37 9.47e-02 1.94e-01 0.23800 -1.86e-01 1.48e-01 5.00e-02 1.20e-01
NPAS4 regulates expression of target genes 16 1.77e-01 3.02e-01 0.23800 4.24e-02 2.34e-01 7.69e-01 1.05e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 50 3.41e-02 9.14e-02 0.23700 -2.07e-01 1.15e-01 1.11e-02 1.60e-01
Termination of O-glycan biosynthesis 16 2.96e-01 4.39e-01 0.23700 2.25e-01 -7.41e-02 1.19e-01 6.08e-01
Signaling by LTK in cancer 7 4.44e-01 5.82e-01 0.23700 2.24e-01 7.64e-02 3.04e-01 7.26e-01
COPI-mediated anterograde transport 92 3.23e-03 1.32e-02 0.23700 -1.72e-01 1.63e-01 4.33e-03 6.90e-03
Transport of Mature Transcript to Cytoplasm 81 1.93e-04 1.07e-03 0.23700 -2.34e-01 -3.69e-02 2.71e-04 5.66e-01
Chemokine receptors bind chemokines 39 1.60e-02 4.93e-02 0.23700 3.89e-02 2.33e-01 6.74e-01 1.16e-02
Hemostasis 562 1.33e-15 3.92e-14 0.23600 -1.54e-01 1.79e-01 4.48e-10 3.71e-13
Formation of RNA Pol II elongation complex 56 3.99e-03 1.58e-02 0.23600 -2.36e-01 -1.38e-02 2.28e-03 8.58e-01
RNA Polymerase II Transcription Elongation 56 3.99e-03 1.58e-02 0.23600 -2.36e-01 -1.38e-02 2.28e-03 8.58e-01
Activation of IRF3, IRF7 mediated by TBK1, IKK (IKBKE) 18 3.05e-01 4.46e-01 0.23600 1.21e-01 -2.03e-01 3.75e-01 1.36e-01
Phase 0 - rapid depolarisation 24 1.19e-01 2.32e-01 0.23600 2.35e-01 -2.08e-02 4.66e-02 8.60e-01
Neurofascin interactions 5 5.65e-01 6.82e-01 0.23600 7.48e-02 2.23e-01 7.72e-01 3.87e-01
APC truncation mutants have impaired AXIN binding 14 1.76e-01 3.00e-01 0.23500 1.98e-01 1.27e-01 2.00e-01 4.09e-01
AXIN missense mutants destabilize the destruction complex 14 1.76e-01 3.00e-01 0.23500 1.98e-01 1.27e-01 2.00e-01 4.09e-01
Signaling by AMER1 mutants 14 1.76e-01 3.00e-01 0.23500 1.98e-01 1.27e-01 2.00e-01 4.09e-01
Signaling by APC mutants 14 1.76e-01 3.00e-01 0.23500 1.98e-01 1.27e-01 2.00e-01 4.09e-01
Signaling by AXIN mutants 14 1.76e-01 3.00e-01 0.23500 1.98e-01 1.27e-01 2.00e-01 4.09e-01
Truncations of AMER1 destabilize the destruction complex 14 1.76e-01 3.00e-01 0.23500 1.98e-01 1.27e-01 2.00e-01 4.09e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 2.56e-01 3.97e-01 0.23500 -1.81e-01 1.49e-01 1.41e-01 2.26e-01
Apoptotic execution phase 46 5.16e-02 1.24e-01 0.23500 -1.24e-01 1.99e-01 1.46e-01 1.95e-02
Acyl chain remodelling of PI 10 3.36e-01 4.78e-01 0.23400 5.78e-02 2.27e-01 7.51e-01 2.14e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 2.26e-03 9.65e-03 0.23400 -2.09e-01 1.05e-01 5.75e-04 8.26e-02
Amplification of signal from the kinetochores 91 2.26e-03 9.65e-03 0.23400 -2.09e-01 1.05e-01 5.75e-04 8.26e-02
Uptake and function of diphtheria toxin 6 4.71e-01 6.05e-01 0.23400 -1.71e-01 -1.60e-01 4.69e-01 4.98e-01
DNA Double-Strand Break Repair 137 5.55e-07 4.77e-06 0.23400 -2.29e-01 -4.61e-02 3.60e-06 3.51e-01
NGF-stimulated transcription 32 1.44e-01 2.62e-01 0.23300 1.67e-01 -1.63e-01 1.02e-01 1.10e-01
SARS-CoV-2-host interactions 183 2.61e-09 3.21e-08 0.23300 -2.26e-01 -5.96e-02 1.39e-07 1.64e-01
CD28 dependent Vav1 pathway 12 4.70e-01 6.05e-01 0.23300 1.30e-01 -1.94e-01 4.37e-01 2.45e-01
Regulation of IFNG signaling 14 1.85e-01 3.12e-01 0.23300 1.21e-01 1.99e-01 4.34e-01 1.98e-01
Sphingolipid metabolism 91 4.14e-03 1.63e-02 0.23300 -1.53e-01 1.75e-01 1.17e-02 3.85e-03
Apoptotic cleavage of cell adhesion proteins 8 5.84e-01 6.98e-01 0.23200 -1.00e-01 2.10e-01 6.23e-01 3.05e-01
Asparagine N-linked glycosylation 286 1.65e-08 1.79e-07 0.23200 -1.98e-01 1.22e-01 8.54e-09 4.05e-04
Axon guidance 459 3.13e-13 8.07e-12 0.23100 -2.02e-01 1.12e-01 1.28e-13 3.93e-05
Dissolution of Fibrin Clot 12 2.94e-01 4.38e-01 0.23000 -2.26e-01 -4.30e-02 1.75e-01 7.97e-01
Dectin-2 family 19 1.34e-01 2.50e-01 0.23000 2.23e-01 5.85e-02 9.28e-02 6.59e-01
Activated NTRK3 signals through RAS 7 4.39e-01 5.79e-01 0.23000 1.99e-01 1.15e-01 3.61e-01 5.97e-01
Trafficking and processing of endosomal TLR 13 3.02e-01 4.44e-01 0.23000 -6.65e-03 -2.30e-01 9.67e-01 1.51e-01
Resolution of Sister Chromatid Cohesion 116 8.56e-04 4.08e-03 0.23000 -1.90e-01 1.29e-01 3.96e-04 1.61e-02
Sensing of DNA Double Strand Breaks 6 6.60e-01 7.67e-01 0.23000 8.21e-02 -2.15e-01 7.27e-01 3.62e-01
Downstream signaling of activated FGFR2 20 1.36e-01 2.52e-01 0.23000 2.27e-01 3.54e-02 7.85e-02 7.84e-01
RHO GTPase Effectors 258 3.06e-07 2.74e-06 0.22900 -1.71e-01 1.53e-01 2.37e-06 2.20e-05
Pyroptosis 25 6.11e-02 1.41e-01 0.22900 -2.11e-01 -8.90e-02 6.74e-02 4.41e-01
Fanconi Anemia Pathway 36 1.57e-02 4.86e-02 0.22900 -2.01e-01 -1.10e-01 3.72e-02 2.52e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.76e-01 4.20e-01 0.22900 1.93e-01 1.23e-01 2.68e-01 4.81e-01
Signaling by FLT3 ITD and TKD mutants 15 1.76e-01 3.00e-01 0.22900 1.98e-01 1.14e-01 1.85e-01 4.43e-01
Bile acid and bile salt metabolism 31 7.68e-02 1.68e-01 0.22800 2.27e-01 -2.27e-02 2.85e-02 8.27e-01
DAG and IP3 signaling 34 1.28e-01 2.44e-01 0.22800 1.90e-01 -1.26e-01 5.48e-02 2.02e-01
Thromboxane signalling through TP receptor 20 3.12e-01 4.53e-01 0.22800 -1.48e-01 1.74e-01 2.53e-01 1.78e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 4.86e-04 2.44e-03 0.22800 -2.17e-01 -6.87e-02 1.43e-03 3.13e-01
Synthesis of bile acids and bile salts 27 9.84e-02 2.01e-01 0.22800 2.28e-01 -9.65e-03 4.05e-02 9.31e-01
Miscellaneous transport and binding events 20 2.79e-01 4.23e-01 0.22800 -1.02e-01 2.04e-01 4.28e-01 1.15e-01
Negative regulation of MET activity 18 1.38e-01 2.55e-01 0.22700 8.85e-02 2.10e-01 5.16e-01 1.24e-01
MHC class II antigen presentation 113 1.58e-04 8.85e-04 0.22700 -2.24e-01 3.88e-02 3.89e-05 4.76e-01
Downstream TCR signaling 89 2.77e-04 1.47e-03 0.22700 -2.27e-01 -1.59e-02 2.17e-04 7.95e-01
DNA Double Strand Break Response 47 2.62e-02 7.40e-02 0.22600 -2.23e-01 3.69e-02 8.06e-03 6.62e-01
Translation of Structural Proteins 9683701 29 1.60e-01 2.82e-01 0.22600 -2.03e-01 9.97e-02 5.83e-02 3.53e-01
IGF1R signaling cascade 38 2.32e-02 6.66e-02 0.22500 2.20e-01 4.78e-02 1.87e-02 6.10e-01
PI3K/AKT activation 8 4.14e-01 5.58e-01 0.22500 9.91e-02 2.02e-01 6.28e-01 3.22e-01
COPI-dependent Golgi-to-ER retrograde traffic 90 5.86e-03 2.18e-02 0.22500 -1.78e-01 1.38e-01 3.58e-03 2.33e-02
IRS-related events triggered by IGF1R 37 2.62e-02 7.40e-02 0.22500 2.20e-01 4.67e-02 2.05e-02 6.23e-01
ChREBP activates metabolic gene expression 7 5.41e-01 6.66e-01 0.22500 5.57e-03 2.25e-01 9.80e-01 3.03e-01
RAS signaling downstream of NF1 loss-of-function variants 7 5.01e-01 6.28e-01 0.22500 2.19e-01 4.87e-02 3.15e-01 8.24e-01
Diseases associated with glycosaminoglycan metabolism 25 2.27e-01 3.63e-01 0.22400 -1.93e-01 1.13e-01 9.50e-02 3.27e-01
Gap junction assembly 17 3.43e-01 4.86e-01 0.22300 -9.01e-02 2.04e-01 5.20e-01 1.45e-01
Signaling by TGFBR3 39 1.06e-01 2.13e-01 0.22300 1.86e-01 -1.23e-01 4.44e-02 1.85e-01
Activation of GABAB receptors 31 3.93e-02 1.01e-01 0.22300 2.07e-01 8.17e-02 4.60e-02 4.31e-01
GABA B receptor activation 31 3.93e-02 1.01e-01 0.22300 2.07e-01 8.17e-02 4.60e-02 4.31e-01
Metabolism of steroid hormones 22 2.19e-01 3.53e-01 0.22200 -2.14e-01 6.03e-02 8.22e-02 6.25e-01
Iron uptake and transport 52 3.86e-02 9.95e-02 0.22100 -2.04e-01 8.58e-02 1.10e-02 2.84e-01
Fertilization 12 3.02e-01 4.45e-01 0.22100 -6.65e-02 -2.11e-01 6.90e-01 2.07e-01
Sphingolipid catabolism 11 5.40e-01 6.66e-01 0.22100 -1.27e-01 1.81e-01 4.67e-01 2.99e-01
Metabolism 1835 9.93e-62 3.84e-59 0.22100 -2.21e-01 2.86e-04 1.10e-55 9.84e-01
Vitamin D (calciferol) metabolism 11 2.92e-01 4.37e-01 0.22100 -1.59e-01 -1.53e-01 3.63e-01 3.78e-01
Laminin interactions 26 5.71e-02 1.33e-01 0.22000 1.30e-01 1.78e-01 2.52e-01 1.16e-01
Biosynthesis of EPA-derived SPMs 6 6.36e-01 7.45e-01 0.22000 2.19e-01 -2.82e-02 3.54e-01 9.05e-01
Phospholipase C-mediated cascade; FGFR2 8 6.42e-01 7.49e-01 0.22000 1.28e-01 -1.79e-01 5.31e-01 3.81e-01
RHOU GTPase cycle 40 5.41e-02 1.29e-01 0.22000 2.17e-01 -3.73e-02 1.76e-02 6.83e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 3.60e-01 5.02e-01 0.22000 -2.19e-01 1.43e-02 1.71e-01 9.29e-01
Regulation of TP53 Activity through Methylation 19 1.29e-01 2.46e-01 0.21900 -1.19e-01 -1.84e-01 3.69e-01 1.65e-01
EML4 and NUDC in mitotic spindle formation 107 2.77e-03 1.15e-02 0.21900 -1.81e-01 1.23e-01 1.23e-03 2.74e-02
Role of ABL in ROBO-SLIT signaling 6 5.35e-01 6.62e-01 0.21900 1.95e-01 9.84e-02 4.07e-01 6.76e-01
Killing mechanisms 9 3.97e-01 5.41e-01 0.21800 -9.18e-02 -1.98e-01 6.33e-01 3.04e-01
WNT5:FZD7-mediated leishmania damping 9 3.97e-01 5.41e-01 0.21800 -9.18e-02 -1.98e-01 6.33e-01 3.04e-01
Glycine degradation 7 6.68e-01 7.72e-01 0.21800 -1.93e-01 1.01e-01 3.77e-01 6.43e-01
CaM pathway 28 2.10e-01 3.42e-01 0.21800 1.85e-01 -1.14e-01 8.94e-02 2.97e-01
Calmodulin induced events 28 2.10e-01 3.42e-01 0.21800 1.85e-01 -1.14e-01 8.94e-02 2.97e-01
Hedgehog ‘on’ state 65 1.19e-02 3.90e-02 0.21800 -2.12e-01 4.93e-02 3.13e-03 4.91e-01
RUNX3 regulates WNT signaling 8 5.97e-01 7.10e-01 0.21700 2.07e-01 -6.60e-02 3.10e-01 7.47e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 6.39e-01 7.47e-01 0.21700 -3.49e-02 -2.15e-01 8.92e-01 4.06e-01
Regulation of pyruvate metabolism 32 1.72e-01 2.97e-01 0.21700 -1.83e-01 1.17e-01 7.32e-02 2.51e-01
Tryptophan catabolism 12 2.74e-01 4.18e-01 0.21700 -1.56e-01 -1.51e-01 3.50e-01 3.66e-01
Signaling by ERBB2 TMD/JMD mutants 17 4.09e-01 5.54e-01 0.21700 1.65e-01 -1.41e-01 2.39e-01 3.15e-01
Nonhomologous End-Joining (NHEJ) 40 8.24e-02 1.77e-01 0.21700 -2.04e-01 7.21e-02 2.55e-02 4.30e-01
Constitutive Signaling by EGFRvIII 14 3.20e-01 4.62e-01 0.21600 2.16e-01 6.44e-03 1.61e-01 9.67e-01
Signaling by EGFRvIII in Cancer 14 3.20e-01 4.62e-01 0.21600 2.16e-01 6.44e-03 1.61e-01 9.67e-01
Activation of PUMA and translocation to mitochondria 9 5.22e-01 6.48e-01 0.21600 2.14e-01 -2.90e-02 2.66e-01 8.80e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.81e-02 9.89e-02 0.21600 -2.13e-01 3.25e-02 1.23e-02 7.03e-01
ER Quality Control Compartment (ERQC) 21 3.33e-01 4.74e-01 0.21600 -1.69e-01 1.35e-01 1.81e-01 2.86e-01
Disorders of transmembrane transporters 137 1.10e-04 6.46e-04 0.21600 -2.10e-01 4.98e-02 2.24e-05 3.15e-01
Signaling by FGFR2 61 4.17e-02 1.04e-01 0.21500 -1.67e-01 1.37e-01 2.44e-02 6.48e-02
Interferon alpha/beta signaling 64 1.16e-03 5.35e-03 0.21500 -1.48e-01 -1.56e-01 4.07e-02 3.12e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 3.96e-01 5.40e-01 0.21500 1.10e-01 -1.84e-01 4.32e-01 1.88e-01
Activation of HOX genes during differentiation 70 1.78e-02 5.38e-02 0.21400 -1.95e-01 9.00e-02 4.86e-03 1.93e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 1.78e-02 5.38e-02 0.21400 -1.95e-01 9.00e-02 4.86e-03 1.93e-01
TP53 Regulates Transcription of DNA Repair Genes 61 4.56e-03 1.76e-02 0.21400 -2.10e-01 -4.16e-02 4.53e-03 5.74e-01
FLT3 signaling through SRC family kinases 6 6.35e-01 7.44e-01 0.21400 2.14e-01 -9.02e-03 3.65e-01 9.69e-01
SARS-CoV-2 Infection 267 1.24e-09 1.63e-08 0.21400 -2.14e-01 2.88e-04 1.87e-09 9.94e-01
HATs acetylate histones 92 9.11e-03 3.14e-02 0.21300 -1.66e-01 1.34e-01 5.84e-03 2.68e-02
Synthesis, secretion, and deacylation of Ghrelin 11 3.18e-01 4.61e-01 0.21300 -1.62e-01 -1.39e-01 3.52e-01 4.26e-01
RHO GTPases Activate Formins 128 6.71e-04 3.26e-03 0.21300 -1.95e-01 8.66e-02 1.43e-04 9.07e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 1.65e-01 2.89e-01 0.21300 2.03e-01 -6.28e-02 5.79e-02 5.59e-01
STAT5 activation downstream of FLT3 ITD mutants 9 4.07e-01 5.52e-01 0.21300 1.03e-01 1.86e-01 5.93e-01 3.33e-01
RHO GTPases activate PAKs 20 2.08e-01 3.40e-01 0.21300 5.71e-03 2.13e-01 9.65e-01 9.96e-02
Uptake and function of anthrax toxins 11 3.55e-01 4.98e-01 0.21300 7.16e-02 2.00e-01 6.81e-01 2.50e-01
Nervous system development 478 5.49e-12 1.06e-10 0.21200 -1.89e-01 9.61e-02 1.27e-12 3.17e-04
Transport of Ribonucleoproteins into the Host Nucleus 32 7.73e-02 1.68e-01 0.21200 -1.30e-02 -2.12e-01 8.99e-01 3.80e-02
Signaling by Retinoic Acid 29 9.04e-02 1.89e-01 0.21200 -2.52e-02 -2.11e-01 8.15e-01 4.96e-02
Transcriptional regulation by RUNX3 81 1.22e-02 3.96e-02 0.21200 -1.87e-01 9.98e-02 3.60e-03 1.20e-01
FGFRL1 modulation of FGFR1 signaling 7 5.75e-01 6.90e-01 0.21200 2.12e-01 9.69e-03 3.32e-01 9.65e-01
Beta-catenin phosphorylation cascade 17 1.89e-01 3.17e-01 0.21200 9.71e-02 1.88e-01 4.88e-01 1.79e-01
Netrin-1 signaling 35 3.71e-02 9.74e-02 0.21100 7.74e-02 1.97e-01 4.28e-01 4.40e-02
SARS-CoV Infections 433 7.50e-13 1.70e-11 0.21100 -2.07e-01 4.29e-02 1.46e-13 1.26e-01
Formation of the Editosome 6 5.66e-01 6.82e-01 0.21100 8.11e-02 1.95e-01 7.31e-01 4.08e-01
mRNA Editing: C to U Conversion 6 5.66e-01 6.82e-01 0.21100 8.11e-02 1.95e-01 7.31e-01 4.08e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 5.59e-01 6.79e-01 0.21100 -1.97e-01 7.57e-02 2.81e-01 6.78e-01
Defective EXT2 causes exostoses 2 10 5.59e-01 6.79e-01 0.21100 -1.97e-01 7.57e-02 2.81e-01 6.78e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 2.57e-01 3.98e-01 0.21000 -2.00e-01 -6.40e-02 1.79e-01 6.68e-01
AMPK inhibits chREBP transcriptional activation activity 6 7.44e-01 8.30e-01 0.21000 -1.53e-01 1.45e-01 5.17e-01 5.39e-01
Activation of RAC1 11 4.94e-01 6.23e-01 0.21000 2.05e-01 -4.62e-02 2.39e-01 7.91e-01
Interleukin-1 signaling 99 4.43e-03 1.72e-02 0.21000 -1.90e-01 9.07e-02 1.11e-03 1.19e-01
Activation of the AP-1 family of transcription factors 10 4.38e-01 5.79e-01 0.21000 2.95e-02 2.08e-01 8.71e-01 2.55e-01
Inhibition of Signaling by Overexpressed EGFR 6 5.66e-01 6.82e-01 0.20900 1.89e-01 8.93e-02 4.22e-01 7.05e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 6 5.66e-01 6.82e-01 0.20900 1.89e-01 8.93e-02 4.22e-01 7.05e-01
FRS-mediated FGFR1 signaling 15 2.78e-01 4.23e-01 0.20900 4.46e-02 2.04e-01 7.65e-01 1.70e-01
Ca-dependent events 30 2.10e-01 3.42e-01 0.20900 1.81e-01 -1.04e-01 8.61e-02 3.25e-01
Signaling by Insulin receptor 63 1.85e-02 5.50e-02 0.20900 -4.48e-02 2.04e-01 5.39e-01 5.13e-03
M-decay: degradation of maternal mRNAs by maternally stored factors 41 9.74e-02 1.99e-01 0.20900 -7.54e-02 1.95e-01 4.04e-01 3.11e-02
RHOQ GTPase cycle 55 2.16e-02 6.29e-02 0.20800 -1.65e-02 2.08e-01 8.33e-01 7.73e-03
EPH-Ephrin signaling 81 1.46e-02 4.59e-02 0.20800 -9.99e-02 1.83e-01 1.20e-01 4.47e-03
TICAM1-dependent activation of IRF3/IRF7 13 4.26e-01 5.68e-01 0.20800 3.20e-02 -2.05e-01 8.41e-01 2.01e-01
SUMOylation of SUMOylation proteins 35 3.68e-02 9.68e-02 0.20700 -9.69e-02 -1.83e-01 3.21e-01 6.03e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 2.14e-01 3.46e-01 0.20700 -1.95e-01 7.02e-02 7.91e-02 5.28e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 3.08e-01 4.49e-01 0.20700 2.02e-01 -4.78e-02 1.28e-01 7.18e-01
Sodium-coupled phosphate cotransporters 5 7.78e-01 8.52e-01 0.20700 1.75e-01 -1.11e-01 4.98e-01 6.67e-01
PKMTs methylate histone lysines 44 1.22e-01 2.36e-01 0.20700 1.52e-01 -1.41e-01 8.03e-02 1.07e-01
Metalloprotease DUBs 20 3.65e-01 5.06e-01 0.20700 -1.76e-01 1.09e-01 1.72e-01 3.99e-01
Cell Cycle 611 2.77e-18 9.73e-17 0.20700 -2.06e-01 2.16e-02 3.15e-18 3.62e-01
Diseases of DNA repair 51 1.17e-02 3.86e-02 0.20700 -1.98e-01 -6.10e-02 1.45e-02 4.51e-01
Transcriptional Regulation by VENTX 39 9.20e-02 1.91e-01 0.20700 4.92e-02 -2.01e-01 5.95e-01 2.99e-02
Signaling by ERBB2 ECD mutants 15 2.71e-01 4.15e-01 0.20700 1.97e-01 6.11e-02 1.86e-01 6.82e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.02e-01 4.44e-01 0.20600 1.60e-01 -1.31e-01 1.67e-01 2.57e-01
Interleukin-27 signaling 11 4.70e-01 6.05e-01 0.20600 -1.55e-02 2.05e-01 9.29e-01 2.38e-01
MAPK3 (ERK1) activation 10 4.44e-01 5.82e-01 0.20500 3.93e-02 2.01e-01 8.30e-01 2.70e-01
Biosynthesis of maresin-like SPMs 5 7.50e-01 8.33e-01 0.20400 1.96e-01 -5.97e-02 4.49e-01 8.17e-01
Ub-specific processing proteases 153 3.85e-04 1.97e-03 0.20400 -1.84e-01 8.94e-02 8.77e-05 5.63e-02
Cell Cycle, Mitotic 488 3.56e-14 9.57e-13 0.20400 -2.03e-01 2.63e-02 1.76e-14 3.19e-01
Signal amplification 28 2.64e-01 4.07e-01 0.20400 -1.18e-01 1.66e-01 2.79e-01 1.29e-01
Regulation of gene expression by Hypoxia-inducible Factor 8 5.41e-01 6.66e-01 0.20300 2.02e-01 2.68e-02 3.23e-01 8.96e-01
Vesicle-mediated transport 669 1.03e-13 2.70e-12 0.20300 -1.51e-01 1.36e-01 2.84e-11 1.96e-09
G-protein activation 19 4.12e-01 5.56e-01 0.20300 -1.22e-01 1.62e-01 3.56e-01 2.22e-01
Nuclear import of Rev protein 34 4.69e-02 1.15e-01 0.20300 -9.35e-02 -1.80e-01 3.45e-01 6.93e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7 6.32e-01 7.42e-01 0.20300 2.02e-01 -1.93e-02 3.55e-01 9.30e-01
Potential therapeutics for SARS 149 9.16e-04 4.34e-03 0.20200 -1.67e-01 1.14e-01 4.30e-04 1.61e-02
Programmed Cell Death 187 8.34e-05 4.99e-04 0.20200 -1.82e-01 8.82e-02 1.81e-05 3.75e-02
RHO GTPases activate CIT 18 4.43e-01 5.82e-01 0.20100 -1.48e-01 1.37e-01 2.79e-01 3.14e-01
RHOV GTPase cycle 36 1.32e-01 2.48e-01 0.20100 1.93e-01 -5.50e-02 4.46e-02 5.68e-01
PI3K Cascade 31 6.99e-02 1.55e-01 0.20000 1.84e-01 8.01e-02 7.67e-02 4.40e-01
Eicosanoids 6 5.78e-01 6.92e-01 0.20000 1.25e-01 1.56e-01 5.97e-01 5.07e-01
Cell junction organization 82 2.30e-02 6.63e-02 0.20000 1.65e-01 -1.12e-01 9.63e-03 7.85e-02
CDC6 association with the ORC:origin complex 8 5.18e-01 6.46e-01 0.20000 -1.89e-01 -6.44e-02 3.55e-01 7.52e-01
Activation of the TFAP2 (AP-2) family of transcription factors 7 6.43e-01 7.50e-01 0.19900 -1.98e-01 2.02e-02 3.63e-01 9.26e-01
Defects in cobalamin (B12) metabolism 13 3.32e-01 4.74e-01 0.19900 -7.86e-02 -1.83e-01 6.24e-01 2.53e-01
CREB phosphorylation 7 6.02e-01 7.15e-01 0.19900 1.98e-01 2.14e-02 3.65e-01 9.22e-01
Dopamine Neurotransmitter Release Cycle 20 4.12e-01 5.56e-01 0.19900 1.54e-01 -1.26e-01 2.34e-01 3.31e-01
Mucopolysaccharidoses 11 6.16e-01 7.29e-01 0.19800 -1.32e-01 1.48e-01 4.48e-01 3.95e-01
Cargo recognition for clathrin-mediated endocytosis 89 1.96e-02 5.78e-02 0.19800 -1.55e-01 1.24e-01 1.17e-02 4.24e-02
NCAM signaling for neurite out-growth 48 6.32e-02 1.44e-01 0.19800 1.94e-01 -4.07e-02 2.01e-02 6.26e-01
Mitotic Prophase 96 6.94e-03 2.49e-02 0.19800 -1.86e-01 6.78e-02 1.62e-03 2.51e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 1.01e-02 3.41e-02 0.19800 -1.97e-01 1.99e-02 3.38e-03 7.68e-01
Signaling by ERBB2 in Cancer 21 2.74e-01 4.18e-01 0.19800 1.97e-01 -2.13e-02 1.19e-01 8.66e-01
Transferrin endocytosis and recycling 26 2.93e-01 4.37e-01 0.19700 -9.33e-02 1.74e-01 4.10e-01 1.25e-01
Regulation of localization of FOXO transcription factors 11 6.10e-01 7.24e-01 0.19700 -1.11e-01 1.63e-01 5.22e-01 3.50e-01
Signaling by cytosolic FGFR1 fusion mutants 18 3.46e-01 4.89e-01 0.19700 1.95e-01 -3.21e-02 1.53e-01 8.14e-01
Homologous DNA Pairing and Strand Exchange 43 3.24e-02 8.75e-02 0.19700 -1.87e-01 -6.21e-02 3.39e-02 4.81e-01
Metabolism of Angiotensinogen to Angiotensins 12 4.79e-01 6.11e-01 0.19700 1.96e-01 -2.03e-02 2.40e-01 9.03e-01
PKA activation 15 3.01e-01 4.44e-01 0.19700 1.86e-01 6.37e-02 2.12e-01 6.69e-01
SUMOylation of RNA binding proteins 47 1.65e-02 5.05e-02 0.19700 -1.61e-01 -1.13e-01 5.61e-02 1.81e-01
Activation of BH3-only proteins 30 2.58e-01 3.99e-01 0.19700 -1.66e-01 1.05e-01 1.15e-01 3.19e-01
Kidney development 17 4.32e-01 5.74e-01 0.19600 -7.63e-02 1.81e-01 5.86e-01 1.96e-01
Ethanol oxidation 8 5.72e-01 6.87e-01 0.19600 -1.96e-01 -1.77e-02 3.38e-01 9.31e-01
Deactivation of the beta-catenin transactivating complex 36 2.06e-01 3.38e-01 0.19500 1.11e-01 -1.61e-01 2.48e-01 9.52e-02
Activation of C3 and C5 7 6.62e-01 7.69e-01 0.19500 -1.94e-01 2.68e-02 3.75e-01 9.02e-01
EGFR Transactivation by Gastrin 7 7.43e-01 8.30e-01 0.19500 1.37e-01 -1.40e-01 5.31e-01 5.23e-01
Drug ADME 59 1.20e-02 3.93e-02 0.19500 -1.90e-01 -4.44e-02 1.15e-02 5.56e-01
mRNA Editing 8 5.92e-01 7.04e-01 0.19500 1.95e-01 2.50e-03 3.39e-01 9.90e-01
DARPP-32 events 22 3.55e-01 4.98e-01 0.19500 -8.64e-02 1.75e-01 4.83e-01 1.55e-01
Ion transport by P-type ATPases 43 1.40e-01 2.57e-01 0.19500 1.71e-01 -9.42e-02 5.26e-02 2.85e-01
Interleukin-35 Signalling 12 4.53e-01 5.89e-01 0.19400 8.16e-03 1.94e-01 9.61e-01 2.45e-01
Biosynthesis of maresins 7 7.00e-01 7.98e-01 0.19400 1.84e-01 -6.08e-02 3.99e-01 7.81e-01
E2F mediated regulation of DNA replication 22 2.94e-01 4.38e-01 0.19400 -1.90e-01 3.69e-02 1.23e-01 7.65e-01
Transcriptional regulation of brown and beige adipocyte differentiation 24 3.66e-01 5.07e-01 0.19300 1.49e-01 -1.23e-01 2.07e-01 2.95e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 24 3.66e-01 5.07e-01 0.19300 1.49e-01 -1.23e-01 2.07e-01 2.95e-01
FLT3 signaling in disease 27 2.81e-01 4.23e-01 0.19300 1.76e-01 -7.83e-02 1.13e-01 4.81e-01
ERKs are inactivated 13 5.60e-01 6.79e-01 0.19300 -1.68e-01 9.43e-02 2.94e-01 5.56e-01
Interactions of Rev with host cellular proteins 37 4.29e-02 1.07e-01 0.19300 -1.29e-01 -1.43e-01 1.74e-01 1.32e-01
SUMOylation of DNA replication proteins 46 1.99e-02 5.85e-02 0.19300 -1.33e-01 -1.40e-01 1.20e-01 1.01e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.01e-01 2.05e-01 0.19300 -3.73e-02 -1.89e-01 7.15e-01 6.43e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.01e-01 2.05e-01 0.19300 -3.73e-02 -1.89e-01 7.15e-01 6.43e-02
Interleukin-4 and Interleukin-13 signaling 93 1.46e-03 6.56e-03 0.19300 1.90e-01 3.24e-02 1.55e-03 5.89e-01
Downregulation of TGF-beta receptor signaling 26 3.31e-01 4.73e-01 0.19200 -1.58e-01 1.09e-01 1.62e-01 3.36e-01
Aspartate and asparagine metabolism 9 6.68e-01 7.72e-01 0.19200 8.77e-02 -1.70e-01 6.49e-01 3.76e-01
SUMOylation of chromatin organization proteins 57 9.10e-03 3.14e-02 0.19100 -1.10e-01 -1.56e-01 1.51e-01 4.11e-02
Mitochondrial biogenesis 91 5.11e-03 1.94e-02 0.19100 -1.90e-01 1.82e-02 1.70e-03 7.64e-01
Transport of fatty acids 5 7.43e-01 8.30e-01 0.19100 -1.27e-02 1.91e-01 9.61e-01 4.60e-01
Collagen chain trimerization 29 1.50e-01 2.70e-01 0.19100 1.90e-01 1.43e-02 7.58e-02 8.94e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.32e-01 2.48e-01 0.19000 -1.80e-01 -6.28e-02 1.06e-01 5.72e-01
Rev-mediated nuclear export of HIV RNA 35 5.52e-02 1.31e-01 0.19000 -1.26e-01 -1.43e-01 1.98e-01 1.44e-01
Triglyceride metabolism 26 1.21e-01 2.34e-01 0.19000 1.57e-01 1.07e-01 1.66e-01 3.44e-01
Intraflagellar transport 47 3.10e-02 8.41e-02 0.19000 -5.89e-02 -1.81e-01 4.85e-01 3.23e-02
IRS-mediated signalling 35 7.09e-02 1.57e-01 0.19000 1.77e-01 6.83e-02 6.98e-02 4.85e-01
WNT ligand biogenesis and trafficking 19 4.13e-01 5.57e-01 0.19000 1.76e-01 -7.05e-02 1.84e-01 5.95e-01
Clathrin-mediated endocytosis 128 5.91e-03 2.19e-02 0.19000 -1.22e-01 1.45e-01 1.72e-02 4.57e-03
Gastrulation 76 2.94e-02 8.08e-02 0.18900 -1.76e-01 7.01e-02 7.99e-03 2.91e-01
Collagen degradation 44 2.90e-02 7.99e-02 0.18900 1.58e-01 1.04e-01 7.00e-02 2.31e-01
PKA-mediated phosphorylation of CREB 17 3.91e-01 5.35e-01 0.18900 1.87e-01 -2.58e-02 1.81e-01 8.54e-01
Transport to the Golgi and subsequent modification 171 1.16e-03 5.36e-03 0.18800 -1.44e-01 1.21e-01 1.15e-03 6.17e-03
Inwardly rectifying K+ channels 24 1.50e-01 2.70e-01 0.18800 9.78e-02 1.61e-01 4.07e-01 1.72e-01
PECAM1 interactions 12 5.16e-01 6.44e-01 0.18800 1.86e-01 -2.22e-02 2.63e-01 8.94e-01
Constitutive Signaling by Aberrant PI3K in Cancer 59 2.20e-02 6.40e-02 0.18700 1.86e-01 2.24e-02 1.34e-02 7.66e-01
Cargo trafficking to the periciliary membrane 47 3.48e-02 9.22e-02 0.18700 -5.54e-02 -1.79e-01 5.11e-01 3.37e-02
Attenuation phase 23 1.99e-01 3.29e-01 0.18700 -4.92e-02 -1.80e-01 6.83e-01 1.34e-01
Mitochondrial unfolded protein response (UPRmt) 17 3.31e-01 4.73e-01 0.18700 -2.46e-02 -1.85e-01 8.60e-01 1.86e-01
ECM proteoglycans 48 5.44e-02 1.30e-01 0.18700 6.23e-03 1.87e-01 9.40e-01 2.53e-02
Activated NTRK2 signals through FRS2 and FRS3 8 5.29e-01 6.55e-01 0.18600 1.33e-01 1.30e-01 5.14e-01 5.23e-01
MAPK1 (ERK2) activation 9 5.00e-01 6.28e-01 0.18600 9.71e-02 1.58e-01 6.14e-01 4.11e-01
Hyaluronan metabolism 16 4.48e-01 5.86e-01 0.18600 -1.81e-01 3.94e-02 2.09e-01 7.85e-01
Signaling by MET 68 1.84e-02 5.46e-02 0.18500 2.96e-03 1.85e-01 9.66e-01 8.36e-03
PKA activation in glucagon signalling 14 3.91e-01 5.35e-01 0.18500 1.80e-01 4.19e-02 2.44e-01 7.86e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 187 7.43e-04 3.61e-03 0.18500 -1.09e-01 1.49e-01 9.99e-03 4.51e-04
EPHA-mediated growth cone collapse 21 2.68e-01 4.11e-01 0.18400 2.23e-02 1.83e-01 8.59e-01 1.47e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 5.52e-02 1.31e-01 0.18400 -1.73e-01 -6.33e-02 5.54e-02 4.83e-01
Diseases of DNA Double-Strand Break Repair 41 5.52e-02 1.31e-01 0.18400 -1.73e-01 -6.33e-02 5.54e-02 4.83e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.08e-01 2.16e-01 0.18400 -4.64e-02 -1.78e-01 6.45e-01 7.65e-02
Costimulation by the CD28 family 74 3.97e-02 1.02e-01 0.18400 6.90e-02 -1.70e-01 3.05e-01 1.12e-02
Receptor-type tyrosine-protein phosphatases 12 4.85e-01 6.17e-01 0.18400 1.83e-01 1.30e-02 2.72e-01 9.38e-01
Signaling by EGFR 48 4.76e-02 1.16e-01 0.18300 2.91e-02 1.81e-01 7.27e-01 3.00e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 191 7.79e-04 3.74e-03 0.18300 -1.42e-01 1.16e-01 7.37e-04 5.53e-03
VxPx cargo-targeting to cilium 19 2.51e-01 3.90e-01 0.18300 1.65e-01 8.00e-02 2.13e-01 5.46e-01
Early SARS-CoV-2 Infection Events 31 1.97e-01 3.27e-01 0.18300 -1.82e-01 2.16e-02 8.00e-02 8.35e-01
Regulation of TP53 Activity through Phosphorylation 88 9.56e-03 3.25e-02 0.18300 -1.82e-01 1.87e-02 3.16e-03 7.61e-01
Signaling by Leptin 10 4.91e-01 6.21e-01 0.18300 1.69e-01 7.10e-02 3.56e-01 6.97e-01
Synthesis of very long-chain fatty acyl-CoAs 22 4.18e-01 5.60e-01 0.18300 -9.25e-02 1.58e-01 4.52e-01 2.01e-01
Regulation of TP53 Expression and Degradation 36 2.57e-01 3.98e-01 0.18200 -1.46e-01 1.10e-01 1.31e-01 2.55e-01
Activation of G protein gated Potassium channels 20 2.22e-01 3.57e-01 0.18200 1.09e-01 1.45e-01 3.98e-01 2.60e-01
G protein gated Potassium channels 20 2.22e-01 3.57e-01 0.18200 1.09e-01 1.45e-01 3.98e-01 2.60e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 2.22e-01 3.57e-01 0.18200 1.09e-01 1.45e-01 3.98e-01 2.60e-01
Gap junction trafficking 28 3.07e-01 4.48e-01 0.18200 -7.13e-02 1.67e-01 5.14e-01 1.26e-01
CLEC7A (Dectin-1) signaling 86 1.40e-02 4.44e-02 0.18200 -1.79e-01 3.04e-02 4.09e-03 6.26e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 4.74e-01 6.08e-01 0.18200 1.11e-01 -1.44e-01 3.91e-01 2.66e-01
Phospholipase C-mediated cascade; FGFR4 6 7.97e-01 8.69e-01 0.18100 1.03e-01 -1.49e-01 6.62e-01 5.27e-01
SARS-CoV-1 activates/modulates innate immune responses 40 6.24e-02 1.43e-01 0.18100 -6.79e-02 -1.68e-01 4.58e-01 6.60e-02
Maturation of nucleoprotein 9694631 15 4.53e-01 5.89e-01 0.18100 -1.42e-02 1.81e-01 9.24e-01 2.26e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 6.27e-02 1.43e-01 0.18000 -1.66e-01 -7.09e-02 6.96e-02 4.38e-01
DAP12 interactions 39 5.67e-02 1.33e-01 0.18000 1.45e-01 1.07e-01 1.18e-01 2.46e-01
Formation of the cornified envelope 36 1.67e-01 2.91e-01 0.18000 -2.65e-02 1.78e-01 7.83e-01 6.43e-02
The NLRP3 inflammasome 16 3.92e-01 5.36e-01 0.18000 -1.58e-02 -1.79e-01 9.13e-01 2.15e-01
Regulation of KIT signaling 15 5.54e-01 6.75e-01 0.18000 1.59e-01 -8.37e-02 2.86e-01 5.75e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 4.51e-01 5.89e-01 0.17900 1.67e-01 -6.59e-02 2.08e-01 6.19e-01
Processing of Intronless Pre-mRNAs 20 4.33e-01 5.74e-01 0.17900 -1.67e-01 6.46e-02 1.96e-01 6.17e-01
ERBB2 Activates PTK6 Signaling 8 6.80e-01 7.83e-01 0.17900 1.76e-01 -3.06e-02 3.88e-01 8.81e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 6 6.96e-01 7.94e-01 0.17900 1.77e-01 2.83e-02 4.54e-01 9.04e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 4.43e-02 1.09e-01 0.17900 2.73e-02 1.76e-01 7.33e-01 2.77e-02
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.11e-01 2.21e-01 0.17800 -7.68e-02 -1.61e-01 4.52e-01 1.15e-01
HS-GAG biosynthesis 20 4.93e-01 6.22e-01 0.17800 -1.20e-01 1.31e-01 3.52e-01 3.09e-01
Transcriptional Regulation by E2F6 34 1.12e-01 2.22e-01 0.17800 -1.70e-01 -5.22e-02 8.61e-02 5.98e-01
Maturation of nucleoprotein 9683610 11 6.25e-01 7.39e-01 0.17800 -5.63e-02 1.69e-01 7.46e-01 3.33e-01
HSF1-dependent transactivation 30 1.66e-01 2.89e-01 0.17800 -2.93e-02 -1.75e-01 7.81e-01 9.66e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.80e-01 4.23e-01 0.17700 -1.77e-01 1.22e-02 1.26e-01 9.16e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.80e-01 4.23e-01 0.17700 -1.77e-01 1.22e-02 1.26e-01 9.16e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 2.80e-01 4.23e-01 0.17700 -1.77e-01 1.22e-02 1.26e-01 9.16e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 2.80e-01 4.23e-01 0.17700 -1.77e-01 1.22e-02 1.26e-01 9.16e-01
Plasma lipoprotein clearance 33 1.44e-01 2.62e-01 0.17700 -1.75e-01 -2.70e-02 8.25e-02 7.89e-01
Regulation of PTEN gene transcription 59 2.15e-02 6.27e-02 0.17600 -6.41e-02 -1.64e-01 3.94e-01 2.95e-02
RHOBTB2 GTPase cycle 23 3.96e-01 5.40e-01 0.17600 -1.64e-01 6.44e-02 1.74e-01 5.93e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.24e-01 2.39e-01 0.17600 2.58e-02 1.74e-01 7.89e-01 7.09e-02
Synthesis of PIPs at the late endosome membrane 11 4.63e-01 5.98e-01 0.17600 1.03e-01 1.42e-01 5.53e-01 4.14e-01
Phospholipase C-mediated cascade: FGFR1 8 6.12e-01 7.25e-01 0.17600 4.35e-02 1.70e-01 8.31e-01 4.04e-01
SHC-mediated cascade:FGFR1 13 4.78e-01 6.11e-01 0.17600 2.01e-02 1.75e-01 9.00e-01 2.76e-01
Regulation of TP53 Degradation 35 2.73e-01 4.17e-01 0.17600 -1.54e-01 8.47e-02 1.15e-01 3.86e-01
Notch-HLH transcription pathway 28 3.57e-01 4.99e-01 0.17500 8.67e-02 -1.53e-01 4.27e-01 1.62e-01
Prolactin receptor signaling 12 4.29e-01 5.71e-01 0.17500 -1.21e-01 -1.26e-01 4.66e-01 4.49e-01
Regulation of HSF1-mediated heat shock response 79 5.94e-03 2.19e-02 0.17500 -1.61e-01 -6.84e-02 1.34e-02 2.93e-01
Signaling by FGFR4 32 2.34e-01 3.70e-01 0.17500 -3.22e-02 1.72e-01 7.52e-01 9.28e-02
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5 7.65e-01 8.42e-01 0.17500 -7.98e-03 -1.74e-01 9.75e-01 4.99e-01
TRAF6 mediated NF-kB activation 23 4.59e-01 5.95e-01 0.17400 1.27e-01 -1.19e-01 2.90e-01 3.23e-01
Hedgehog ‘off’ state 91 1.64e-02 5.04e-02 0.17400 -1.71e-01 3.17e-02 4.72e-03 6.02e-01
Gene Silencing by RNA 87 1.34e-02 4.30e-02 0.17400 -1.74e-01 9.68e-03 5.04e-03 8.76e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 4.73e-01 6.07e-01 0.17400 1.46e-01 9.46e-02 4.01e-01 5.87e-01
Maturation of protein 3a 9683673 9 7.27e-01 8.18e-01 0.17400 9.33e-02 -1.47e-01 6.28e-01 4.45e-01
Maturation of protein 3a 9694719 9 7.27e-01 8.18e-01 0.17400 9.33e-02 -1.47e-01 6.28e-01 4.45e-01
Surfactant metabolism 21 4.90e-01 6.20e-01 0.17400 -1.13e-01 1.33e-01 3.71e-01 2.93e-01
Post-translational modification: synthesis of GPI-anchored proteins 59 1.79e-02 5.38e-02 0.17400 -1.41e-01 -1.02e-01 6.12e-02 1.77e-01
Signaling by FGFR3 32 2.19e-01 3.53e-01 0.17300 -1.80e-02 1.72e-01 8.60e-01 9.15e-02
Acyl chain remodeling of CL 5 8.10e-01 8.80e-01 0.17300 1.67e-01 -4.37e-02 5.18e-01 8.66e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.16e-01 2.29e-01 0.17200 -1.64e-01 -4.96e-02 8.80e-02 6.07e-01
Signaling by BRAF and RAF1 fusions 60 1.32e-01 2.49e-01 0.17100 -1.41e-01 9.70e-02 5.86e-02 1.94e-01
Regulation of TBK1, IKK (IKBKE)-mediated activation of IRF3, IRF7 14 6.26e-01 7.39e-01 0.17100 9.84e-02 -1.40e-01 5.24e-01 3.66e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 29 3.89e-01 5.32e-01 0.17000 -1.08e-01 1.32e-01 3.14e-01 2.20e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 1.58e-01 2.80e-01 0.17000 -6.68e-02 1.56e-01 4.14e-01 5.57e-02
ER to Golgi Anterograde Transport 145 9.64e-03 3.27e-02 0.17000 -1.29e-01 1.10e-01 7.44e-03 2.18e-02
MET activates PTK2 signaling 23 4.58e-01 5.93e-01 0.16900 -8.67e-02 1.46e-01 4.71e-01 2.27e-01
Fatty acid metabolism 155 1.18e-04 6.87e-04 0.16900 -1.61e-01 -5.14e-02 5.24e-04 2.70e-01
Rap1 signalling 14 4.53e-01 5.89e-01 0.16900 4.04e-02 1.64e-01 7.93e-01 2.87e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 2.58e-01 3.99e-01 0.16900 1.53e-01 7.10e-02 2.13e-01 5.64e-01
Signaling by PDGFRA extracellular domain mutants 12 5.36e-01 6.63e-01 0.16900 1.68e-01 1.68e-02 3.13e-01 9.20e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 5.36e-01 6.63e-01 0.16900 1.68e-01 1.68e-02 3.13e-01 9.20e-01
Transport of the SLBP Dependant Mature mRNA 36 9.54e-02 1.96e-01 0.16900 -1.13e-01 -1.25e-01 2.40e-01 1.93e-01
Peptide ligand-binding receptors 101 3.47e-03 1.41e-02 0.16900 4.01e-02 1.64e-01 4.86e-01 4.42e-03
Vitamin B5 (pantothenate) metabolism 20 2.94e-01 4.38e-01 0.16900 -6.99e-02 -1.53e-01 5.88e-01 2.35e-01
NRAGE signals death through JNK 52 1.78e-01 3.03e-01 0.16900 1.43e-01 -8.98e-02 7.52e-02 2.63e-01
NS1 Mediated Effects on Host Pathways 40 9.92e-02 2.02e-01 0.16900 -4.95e-02 -1.61e-01 5.88e-01 7.79e-02
Signalling to ERKs 32 2.02e-01 3.32e-01 0.16800 8.72e-03 1.68e-01 9.32e-01 9.96e-02
Phosphate bond hydrolysis by NTPDase proteins 5 7.87e-01 8.61e-01 0.16800 -7.27e-05 -1.68e-01 1.00e+00 5.16e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 4.92e-01 6.21e-01 0.16700 9.45e-02 -1.38e-01 4.43e-01 2.62e-01
Reproduction 85 3.45e-02 9.19e-02 0.16700 -1.62e-01 4.14e-02 9.81e-03 5.10e-01
Defective RIPK1-mediated regulated necrosis 7 7.46e-01 8.30e-01 0.16700 2.99e-02 -1.64e-01 8.91e-01 4.51e-01
Erythropoietin activates RAS 13 4.86e-01 6.18e-01 0.16700 1.62e-01 4.14e-02 3.12e-01 7.96e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 2.81e-01 4.23e-01 0.16700 -1.67e-01 1.60e-03 1.34e-01 9.89e-01
Interferon gamma signaling 90 1.41e-02 4.45e-02 0.16700 -7.22e-04 -1.67e-01 9.91e-01 6.26e-03
Synthesis of IP2, IP, and Ins in the cytosol 13 6.30e-01 7.42e-01 0.16700 1.53e-01 -6.48e-02 3.38e-01 6.86e-01
Insulin receptor signalling cascade 40 8.37e-02 1.79e-01 0.16600 8.93e-02 1.41e-01 3.28e-01 1.24e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 6.88e-01 7.89e-01 0.16600 -1.64e-01 2.92e-02 3.95e-01 8.79e-01
PTEN Regulation 127 1.43e-03 6.46e-03 0.16600 -1.64e-01 -2.43e-02 1.37e-03 6.36e-01
O-linked glycosylation 85 2.32e-02 6.66e-02 0.16600 1.65e-01 -1.25e-02 8.40e-03 8.42e-01
Disease 1633 1.85e-26 8.72e-25 0.16600 -1.61e-01 4.10e-02 2.38e-27 5.77e-03
Beta-catenin independent WNT signaling 126 1.71e-02 5.21e-02 0.16500 -1.43e-01 8.36e-02 5.73e-03 1.05e-01
Histidine catabolism 7 7.32e-01 8.23e-01 0.16500 1.65e-01 -9.70e-03 4.50e-01 9.65e-01
Diseases associated with surfactant metabolism 6 8.24e-01 8.92e-01 0.16500 -8.53e-02 1.41e-01 7.17e-01 5.49e-01
Establishment of Sister Chromatid Cohesion 11 5.92e-01 7.04e-01 0.16500 1.65e-01 6.55e-03 3.44e-01 9.70e-01
Transcriptional regulation by RUNX1 170 5.95e-03 2.19e-02 0.16500 -1.12e-01 1.21e-01 1.17e-02 6.45e-03
Adipogenesis 96 5.52e-02 1.31e-01 0.16500 1.19e-01 -1.15e-01 4.48e-02 5.20e-02
SUMOylation of DNA damage response and repair proteins 77 1.04e-02 3.47e-02 0.16500 -7.58e-02 -1.46e-01 2.50e-01 2.63e-02
Impaired BRCA2 binding to PALB2 24 3.43e-01 4.86e-01 0.16500 -1.64e-01 8.07e-03 1.63e-01 9.45e-01
Diseases of mitotic cell cycle 38 1.16e-01 2.29e-01 0.16400 -1.54e-01 -5.80e-02 1.01e-01 5.36e-01
Apoptotic cleavage of cellular proteins 35 2.50e-01 3.90e-01 0.16400 -3.33e-02 1.61e-01 7.33e-01 9.96e-02
Cell-Cell communication 114 2.24e-02 6.50e-02 0.16400 1.48e-01 -7.15e-02 6.39e-03 1.87e-01
PIWI-interacting RNA (piRNA) biogenesis 23 2.54e-01 3.94e-01 0.16400 -1.41e-01 -8.38e-02 2.43e-01 4.87e-01
activated TAK1 mediates p38 MAPK activation 23 4.98e-01 6.27e-01 0.16400 -1.01e-01 1.29e-01 4.02e-01 2.84e-01
Synthesis of substrates in N-glycan biosythesis 59 8.05e-02 1.74e-01 0.16300 -1.63e-01 1.44e-02 3.05e-02 8.49e-01
Circadian Clock 67 1.08e-01 2.16e-01 0.16300 1.48e-01 -7.00e-02 3.65e-02 3.22e-01
Formation of annular gap junctions 10 7.23e-01 8.16e-01 0.16300 -1.45e-01 7.61e-02 4.29e-01 6.77e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 1.50e-01 2.70e-01 0.16300 6.84e-02 1.48e-01 4.97e-01 1.40e-01
SHC1 events in EGFR signaling 12 5.05e-01 6.32e-01 0.16300 1.50e-01 6.52e-02 3.69e-01 6.96e-01
HDACs deacetylate histones 45 1.06e-01 2.13e-01 0.16300 -1.61e-01 -2.47e-02 6.17e-02 7.74e-01
Metabolism of vitamins and cofactors 166 6.29e-05 3.92e-04 0.16300 -1.41e-01 -8.10e-02 1.70e-03 7.18e-02
Erythropoietin activates STAT5 6 7.64e-01 8.42e-01 0.16200 5.15e-04 -1.62e-01 9.98e-01 4.91e-01
Potassium Channels 64 5.91e-02 1.37e-01 0.16200 1.62e-01 -3.38e-03 2.47e-02 9.63e-01
RHOG GTPase cycle 71 7.15e-02 1.58e-01 0.16200 -4.03e-02 1.57e-01 5.58e-01 2.22e-02
Neutrophil degranulation 458 7.30e-07 6.10e-06 0.16200 -7.88e-02 1.41e-01 3.85e-03 2.13e-07
Zinc influx into cells by the SLC39 gene family 9 6.68e-01 7.72e-01 0.16200 1.51e-03 1.62e-01 9.94e-01 4.01e-01
Transport and synthesis of PAPS 6 7.68e-01 8.43e-01 0.16100 -1.61e-01 1.46e-03 4.94e-01 9.95e-01
Transport of the SLBP independent Mature mRNA 35 1.29e-01 2.46e-01 0.16100 -8.96e-02 -1.34e-01 3.59e-01 1.70e-01
G0 and Early G1 27 3.62e-01 5.04e-01 0.16100 -1.57e-01 3.51e-02 1.58e-01 7.52e-01
L1CAM interactions 100 2.85e-02 7.90e-02 0.16000 -4.34e-02 1.54e-01 4.53e-01 7.77e-03
ROS and RNS production in phagocytes 30 4.12e-01 5.56e-01 0.16000 -8.87e-02 1.33e-01 4.00e-01 2.07e-01
Activation of gene expression by SREBF (SREBP) 42 2.89e-01 4.33e-01 0.16000 1.33e-01 -8.81e-02 1.35e-01 3.23e-01
Metabolism of water-soluble vitamins and cofactors 115 1.36e-03 6.19e-03 0.15900 -1.00e-01 -1.23e-01 6.36e-02 2.23e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 9.14e-02 1.90e-01 0.15900 -1.38e-01 -7.85e-02 1.18e-01 3.73e-01
SUMOylation of transcription factors 16 3.99e-01 5.43e-01 0.15900 -1.23e-01 -9.98e-02 3.93e-01 4.90e-01
Cellular response to heat stress 94 5.71e-03 2.14e-02 0.15800 -1.39e-01 -7.52e-02 1.95e-02 2.08e-01
Deadenylation of mRNA 22 5.14e-01 6.43e-01 0.15800 -1.39e-01 7.42e-02 2.58e-01 5.47e-01
IRAK2 mediated activation of TAK1 complex 10 6.65e-01 7.71e-01 0.15700 -1.57e-01 7.07e-03 3.90e-01 9.69e-01
TNFR1-induced NF-kappa-B signaling pathway 32 4.14e-01 5.58e-01 0.15700 1.06e-01 -1.16e-01 2.99e-01 2.56e-01
Signaling by MAPK mutants 6 7.65e-01 8.42e-01 0.15700 -1.39e-02 -1.57e-01 9.53e-01 5.07e-01
Cardiac conduction 89 3.35e-02 9.00e-02 0.15700 1.56e-01 -2.03e-02 1.11e-02 7.41e-01
Regulation of TP53 Activity through Acetylation 29 4.50e-01 5.88e-01 0.15700 1.02e-01 -1.19e-01 3.44e-01 2.66e-01
Ca2+ pathway 58 6.72e-02 1.51e-01 0.15700 1.54e-01 2.63e-02 4.19e-02 7.29e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 2.75e-01 4.19e-01 0.15600 -1.53e-01 3.15e-02 1.12e-01 7.44e-01
GRB2 events in EGFR signaling 11 5.64e-01 6.81e-01 0.15600 1.43e-01 6.32e-02 4.13e-01 7.17e-01
GPVI-mediated activation cascade 33 1.61e-01 2.83e-01 0.15600 9.65e-02 1.22e-01 3.37e-01 2.24e-01
SLC15A4:TASL-dependent IRF5 activation 6 8.42e-01 8.99e-01 0.15500 -7.59e-02 1.35e-01 7.48e-01 5.67e-01
ISG15 antiviral mechanism 72 3.10e-02 8.41e-02 0.15500 -1.49e-01 -4.33e-02 2.93e-02 5.25e-01
SUMOylation of ubiquitinylation proteins 39 1.24e-01 2.39e-01 0.15400 -1.24e-01 -9.04e-02 1.79e-01 3.29e-01
Keratinization 37 2.37e-01 3.74e-01 0.15300 -6.28e-03 1.53e-01 9.47e-01 1.07e-01
Signaling by PDGF 50 6.79e-02 1.52e-01 0.15300 1.14e-01 1.02e-01 1.63e-01 2.10e-01
Aquaporin-mediated transport 38 1.65e-01 2.89e-01 0.15300 4.32e-02 1.47e-01 6.45e-01 1.17e-01
Interleukin-1 family signaling 127 3.73e-02 9.76e-02 0.15300 -1.07e-01 1.10e-01 3.78e-02 3.30e-02
Glucagon signaling in metabolic regulation 26 2.57e-01 3.98e-01 0.15200 8.44e-02 1.27e-01 4.56e-01 2.63e-01
Antigen processing: Ubiquitination & Proteasome degradation 275 2.62e-04 1.40e-03 0.15200 -1.42e-01 5.27e-02 4.90e-05 1.33e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 7.46e-01 8.30e-01 0.15100 -8.32e-02 1.26e-01 6.33e-01 4.68e-01
Recruitment of NuMA to mitotic centrosomes 88 2.88e-02 7.96e-02 0.15100 -1.51e-01 -8.14e-03 1.43e-02 8.95e-01
Gap junction trafficking and regulation 30 4.09e-01 5.54e-01 0.15100 -5.49e-02 1.41e-01 6.03e-01 1.81e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 4.88e-01 6.18e-01 0.15100 -9.53e-02 1.17e-01 3.83e-01 2.84e-01
Mitotic Prometaphase 193 2.49e-03 1.05e-02 0.15100 -1.44e-01 4.38e-02 5.41e-04 2.94e-01
Synthesis of pyrophosphates in the cytosol 8 6.80e-01 7.83e-01 0.15100 -5.77e-02 -1.39e-01 7.77e-01 4.95e-01
FRS-mediated FGFR3 signaling 12 5.80e-01 6.93e-01 0.15100 3.92e-02 1.46e-01 8.14e-01 3.83e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 34 2.47e-01 3.87e-01 0.15000 -1.49e-01 -1.53e-02 1.32e-01 8.77e-01
TGF-beta receptor signaling activates SMADs 45 3.23e-01 4.65e-01 0.15000 -1.12e-01 1.00e-01 1.96e-01 2.44e-01
Biological oxidations 146 7.37e-03 2.60e-02 0.15000 -1.48e-01 2.59e-02 2.05e-03 5.89e-01
TNFs bind their physiological receptors 25 4.85e-01 6.17e-01 0.14900 5.55e-02 -1.39e-01 6.31e-01 2.30e-01
Cyclin D associated events in G1 47 1.38e-01 2.55e-01 0.14900 -1.47e-01 -2.46e-02 8.12e-02 7.70e-01
G1 Phase 47 1.38e-01 2.55e-01 0.14900 -1.47e-01 -2.46e-02 8.12e-02 7.70e-01
RAB geranylgeranylation 61 2.13e-01 3.45e-01 0.14900 -8.69e-02 1.21e-01 2.40e-01 1.02e-01
Signaling by Hippo 18 4.18e-01 5.60e-01 0.14900 6.75e-02 1.33e-01 6.20e-01 3.29e-01
RNA polymerase II transcribes snRNA genes 71 4.91e-02 1.19e-01 0.14900 -1.46e-01 -2.80e-02 3.33e-02 6.83e-01
Free fatty acids regulate insulin secretion 10 7.06e-01 8.01e-01 0.14800 1.48e-01 -1.52e-02 4.19e-01 9.34e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 6.22e-01 7.36e-01 0.14800 -8.72e-02 1.20e-01 5.11e-01 3.67e-01
Resolution of D-Loop Structures 35 2.55e-01 3.96e-01 0.14800 -1.48e-01 -1.03e-02 1.31e-01 9.16e-01
EPHB-mediated forward signaling 40 3.75e-01 5.17e-01 0.14800 -9.27e-02 1.15e-01 3.10e-01 2.08e-01
PKR-mediated signaling 67 1.59e-01 2.81e-01 0.14800 -1.35e-01 6.00e-02 5.64e-02 3.96e-01
Tight junction interactions 17 4.40e-01 5.80e-01 0.14700 -1.25e-01 -7.70e-02 3.71e-01 5.83e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 3.35e-01 4.77e-01 0.14700 5.50e-02 1.36e-01 6.41e-01 2.49e-01
ADORA2B mediated anti-inflammatory cytokines production 36 2.75e-01 4.19e-01 0.14700 -4.43e-03 1.47e-01 9.63e-01 1.28e-01
Transcriptional regulation of white adipocyte differentiation 77 1.56e-01 2.78e-01 0.14600 1.16e-01 -8.85e-02 7.80e-02 1.79e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.33e-01 2.49e-01 0.14600 -1.19e-01 -8.46e-02 1.83e-01 3.43e-01
MTOR signalling 39 3.37e-01 4.79e-01 0.14600 -1.36e-01 5.07e-02 1.40e-01 5.84e-01
Antiviral mechanism by IFN-stimulated genes 140 5.92e-03 2.19e-02 0.14500 -1.45e-01 -4.82e-03 2.99e-03 9.22e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.10e-01 3.42e-01 0.14500 -4.57e-02 -1.38e-01 6.35e-01 1.52e-01
Signaling by FGFR1 in disease 32 2.41e-01 3.80e-01 0.14500 1.35e-01 5.36e-02 1.86e-01 6.00e-01
Class I MHC mediated antigen processing & presentation 344 1.53e-04 8.63e-04 0.14500 -1.30e-01 6.50e-02 3.52e-05 3.83e-02
TCR signaling 110 1.12e-02 3.72e-02 0.14400 -1.41e-01 -3.28e-02 1.08e-02 5.52e-01
Membrane Trafficking 577 2.42e-06 1.88e-05 0.14400 -1.06e-01 9.66e-02 1.29e-05 7.33e-05
GPER1 signaling 38 3.62e-01 5.04e-01 0.14300 -5.21e-02 1.34e-01 5.78e-01 1.54e-01
Signaling by NOTCH 175 1.01e-02 3.41e-02 0.14300 -1.33e-01 5.36e-02 2.48e-03 2.21e-01
RAC1 GTPase cycle 173 4.98e-03 1.91e-02 0.14300 1.41e-01 -2.38e-02 1.38e-03 5.90e-01
HDR through Single Strand Annealing (SSA) 37 1.77e-01 3.01e-01 0.14300 -9.80e-02 -1.04e-01 3.02e-01 2.74e-01
Signaling by PDGFR in disease 19 5.48e-01 6.70e-01 0.14300 1.42e-01 -1.77e-02 2.86e-01 8.94e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 2.09e-02 6.12e-02 0.14200 1.20e-01 7.57e-02 5.41e-02 2.25e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 4.54e-01 5.89e-01 0.14200 -4.60e-02 -1.34e-01 7.29e-01 3.11e-01
Activation of Matrix Metalloproteinases 22 3.63e-01 5.05e-01 0.14200 9.59e-02 1.04e-01 4.36e-01 3.96e-01
Nicotinamide salvaging 15 7.05e-01 8.01e-01 0.14200 -7.75e-02 1.18e-01 6.03e-01 4.27e-01
Degradation of the extracellular matrix 99 1.26e-02 4.07e-02 0.14100 1.20e-01 7.37e-02 3.87e-02 2.05e-01
Oxidative Stress Induced Senescence 77 1.56e-01 2.78e-01 0.14100 -1.25e-01 6.55e-02 5.82e-02 3.21e-01
Nephron development 5 8.94e-01 9.28e-01 0.14100 8.71e-02 -1.11e-01 7.36e-01 6.68e-01
Assembly and cell surface presentation of NMDA receptors 34 3.24e-01 4.66e-01 0.14100 1.41e-01 -3.18e-03 1.56e-01 9.74e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 7.45e-01 8.30e-01 0.14100 1.30e-01 5.43e-02 5.52e-01 8.03e-01
Regulation of TBK1, IKK-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 7.64e-01 8.42e-01 0.14000 6.01e-02 -1.26e-01 7.30e-01 4.68e-01
Defective B4GALT7 causes EDS, progeroid type 11 6.38e-01 7.46e-01 0.14000 -1.31e-01 -4.82e-02 4.51e-01 7.82e-01
Cilium Assembly 186 4.57e-04 2.31e-03 0.14000 -5.46e-02 -1.29e-01 1.99e-01 2.44e-03
Interleukin-12 family signaling 53 2.95e-01 4.38e-01 0.14000 -1.20e-01 7.20e-02 1.31e-01 3.64e-01
Negative regulation of the PI3K/AKT network 93 1.79e-02 5.38e-02 0.14000 1.19e-01 7.24e-02 4.67e-02 2.28e-01
Cytosolic sensors of pathogen-associated DNA 63 1.44e-01 2.62e-01 0.13900 -1.38e-01 1.20e-02 5.77e-02 8.69e-01
SUMO E3 ligases SUMOylate target proteins 161 7.01e-03 2.50e-02 0.13900 1.08e-02 -1.38e-01 8.13e-01 2.46e-03
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 85 1.24e-01 2.39e-01 0.13800 -5.21e-02 1.28e-01 4.07e-01 4.16e-02
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 85 1.24e-01 2.39e-01 0.13800 -5.21e-02 1.28e-01 4.07e-01 4.16e-02
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 85 1.24e-01 2.39e-01 0.13800 -5.21e-02 1.28e-01 4.07e-01 4.16e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 6.80e-01 7.83e-01 0.13800 -1.37e-01 -1.66e-02 4.32e-01 9.24e-01
Centrosome maturation 81 3.48e-02 9.22e-02 0.13800 -1.21e-01 -6.51e-02 5.93e-02 3.11e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.48e-02 9.22e-02 0.13800 -1.21e-01 -6.51e-02 5.93e-02 3.11e-01
cGMP effects 12 7.77e-01 8.52e-01 0.13700 -1.01e-01 9.35e-02 5.46e-01 5.75e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 5.46e-01 6.69e-01 0.13700 -9.50e-02 -9.91e-02 5.38e-01 5.21e-01
Regulation of insulin secretion 63 1.25e-01 2.39e-01 0.13700 1.37e-01 6.14e-03 5.98e-02 9.33e-01
GRB2 events in ERBB2 signaling 11 6.90e-01 7.90e-01 0.13700 1.37e-01 1.03e-02 4.32e-01 9.53e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 6.59e-01 7.66e-01 0.13700 3.76e-02 -1.32e-01 7.95e-01 3.62e-01
Cytoprotection by HMOX1 53 3.00e-01 4.44e-01 0.13700 -6.42e-02 1.21e-01 4.19e-01 1.28e-01
Sensory Perception 197 2.46e-04 1.32e-03 0.13600 9.62e-02 9.63e-02 1.99e-02 1.98e-02
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 8.40e-01 8.99e-01 0.13500 -4.17e-02 1.29e-01 8.49e-01 5.55e-01
Semaphorin interactions 56 2.00e-01 3.30e-01 0.13500 -1.48e-02 1.34e-01 8.48e-01 8.21e-02
Negative regulators of DDX58/IFIH1 signaling 34 2.79e-01 4.23e-01 0.13500 -1.28e-01 -4.27e-02 1.96e-01 6.67e-01
Regulation of lipid metabolism by PPARalpha 107 9.13e-02 1.90e-01 0.13500 5.99e-02 -1.21e-01 2.84e-01 3.07e-02
SUMOylation 167 6.25e-03 2.28e-02 0.13500 2.20e-03 -1.35e-01 9.61e-01 2.66e-03
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 59 2.30e-01 3.66e-01 0.13500 -3.89e-02 1.29e-01 6.05e-01 8.67e-02
Transcriptional Regulation by TP53 346 8.07e-05 4.87e-04 0.13400 -1.33e-01 2.00e-02 2.14e-05 5.23e-01
Glycosphingolipid metabolism 46 3.98e-01 5.42e-01 0.13400 -9.64e-02 9.34e-02 2.58e-01 2.73e-01
HDL remodeling 6 8.32e-01 8.94e-01 0.13400 -1.34e-01 -6.06e-04 5.70e-01 9.98e-01
Downregulation of ERBB2:ERBB3 signaling 12 6.16e-01 7.29e-01 0.13400 -1.10e-01 -7.56e-02 5.08e-01 6.50e-01
Synthesis of IP3 and IP4 in the cytosol 22 5.81e-01 6.94e-01 0.13400 1.28e-01 -3.77e-02 2.98e-01 7.60e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 1.32e-01 2.48e-01 0.13400 1.06e-01 8.08e-02 1.93e-01 3.23e-01
Regulation of FZD by ubiquitination 16 5.39e-01 6.65e-01 0.13400 1.20e-01 5.79e-02 4.04e-01 6.89e-01
Inositol phosphate metabolism 42 4.32e-01 5.74e-01 0.13400 8.62e-02 -1.02e-01 3.34e-01 2.53e-01
Regulation of PLK1 Activity at G2/M Transition 87 4.04e-02 1.03e-01 0.13300 -1.26e-01 -4.50e-02 4.29e-02 4.69e-01
O-linked glycosylation of mucins 47 1.97e-01 3.26e-01 0.13300 1.30e-01 2.89e-02 1.23e-01 7.32e-01
Impaired BRCA2 binding to RAD51 35 2.47e-01 3.87e-01 0.13200 -9.48e-02 -9.18e-02 3.32e-01 3.47e-01
Keratan sulfate biosynthesis 20 6.64e-01 7.71e-01 0.13200 1.12e-01 -6.89e-02 3.84e-01 5.94e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.78e-01 7.82e-01 0.13200 -7.15e-02 -1.11e-01 6.95e-01 5.45e-01
Interleukin-12 signaling 44 3.75e-01 5.17e-01 0.13200 -1.22e-01 4.97e-02 1.62e-01 5.69e-01
Fatty acyl-CoA biosynthesis 35 5.00e-01 6.28e-01 0.13100 -7.54e-02 1.08e-01 4.40e-01 2.70e-01
Gain-of-function MRAS complexes activate RAF signaling 8 8.57e-01 9.09e-01 0.13100 8.86e-02 -9.70e-02 6.64e-01 6.35e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 8.57e-01 9.09e-01 0.13100 8.86e-02 -9.70e-02 6.64e-01 6.35e-01
Signaling by MRAS-complex mutants 8 8.57e-01 9.09e-01 0.13100 8.86e-02 -9.70e-02 6.64e-01 6.35e-01
Kinesins 51 3.43e-01 4.86e-01 0.13100 -5.99e-02 1.17e-01 4.59e-01 1.50e-01
Endogenous sterols 18 6.92e-01 7.93e-01 0.13100 1.13e-01 -6.52e-02 4.05e-01 6.32e-01
Signaling by NTRK2 (TRKB) 20 4.66e-01 6.01e-01 0.13100 1.11e-01 6.93e-02 3.91e-01 5.92e-01
STAT5 Activation 7 8.27e-01 8.92e-01 0.13100 1.30e-01 -1.24e-02 5.52e-01 9.55e-01
AURKA Activation by TPX2 72 9.26e-02 1.91e-01 0.13000 -1.28e-01 -2.73e-02 6.12e-02 6.89e-01
Striated Muscle Contraction 27 4.15e-01 5.58e-01 0.13000 1.28e-01 2.39e-02 2.49e-01 8.30e-01
Innate Immune System 971 2.37e-08 2.54e-07 0.13000 -8.44e-02 9.87e-02 8.40e-06 1.89e-07
GPCR ligand binding 241 6.49e-04 3.17e-03 0.13000 1.29e-01 1.34e-02 5.54e-04 7.21e-01
FGFR1c ligand binding and activation 8 8.54e-01 9.07e-01 0.12900 -1.11e-01 6.73e-02 5.88e-01 7.42e-01
G alpha (q) signalling events 139 6.93e-03 2.49e-02 0.12900 1.18e-01 5.38e-02 1.67e-02 2.74e-01
Downregulation of ERBB2 signaling 24 4.28e-01 5.70e-01 0.12900 -1.19e-01 -4.96e-02 3.12e-01 6.74e-01
RHOH GTPase cycle 34 3.26e-01 4.67e-01 0.12900 3.28e-02 1.24e-01 7.41e-01 2.09e-01
Organelle biogenesis and maintenance 277 3.32e-05 2.20e-04 0.12800 -9.98e-02 -8.08e-02 4.24e-03 2.06e-02
CS/DS degradation 9 7.39e-01 8.29e-01 0.12800 -1.22e-01 -3.90e-02 5.27e-01 8.39e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 8.25e-01 8.92e-01 0.12800 1.25e-01 -2.55e-02 5.39e-01 9.01e-01
Nuclear Events (kinase and transcription factor activation) 54 3.67e-01 5.08e-01 0.12800 1.03e-01 -7.63e-02 1.92e-01 3.32e-01
Defective B3GAT3 causes JDSSDHD 11 6.79e-01 7.83e-01 0.12800 -1.16e-01 -5.32e-02 5.05e-01 7.60e-01
DAP12 signaling 28 3.51e-01 4.94e-01 0.12800 9.44e-02 8.61e-02 3.87e-01 4.30e-01
Plasma lipoprotein assembly 10 7.51e-01 8.33e-01 0.12700 1.27e-01 6.24e-03 4.86e-01 9.73e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7 8.29e-01 8.92e-01 0.12700 3.86e-03 -1.27e-01 9.86e-01 5.61e-01
CTLA4 inhibitory signaling 21 5.78e-01 6.92e-01 0.12700 1.27e-01 -8.59e-03 3.16e-01 9.46e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 8.06e-01 8.78e-01 0.12700 -9.45e-02 8.44e-02 5.71e-01 6.13e-01
Neuronal System 276 4.41e-04 2.24e-03 0.12700 1.26e-01 6.71e-03 3.00e-04 8.48e-01
Interferon Signaling 240 1.81e-04 1.01e-03 0.12600 -1.01e-01 -7.61e-02 7.13e-03 4.23e-02
Cell recruitment (pro-inflammatory response) 25 4.16e-01 5.59e-01 0.12600 -1.11e-01 -6.08e-02 3.39e-01 5.99e-01
Purinergic signaling in leishmaniasis infection 25 4.16e-01 5.59e-01 0.12600 -1.11e-01 -6.08e-02 3.39e-01 5.99e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 2.93e-01 4.37e-01 0.12600 5.13e-02 1.15e-01 5.94e-01 2.32e-01
Neurotransmitter release cycle 38 4.26e-01 5.68e-01 0.12600 1.22e-01 -3.18e-02 1.93e-01 7.34e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 6.34e-03 2.30e-02 0.12600 9.93e-02 7.73e-02 4.17e-02 1.13e-01
Metabolism of amine-derived hormones 10 8.21e-01 8.90e-01 0.12600 1.14e-01 -5.34e-02 5.33e-01 7.70e-01
Post-translational protein modification 1243 4.84e-12 9.54e-11 0.12600 -1.21e-01 3.31e-02 6.18e-13 4.93e-02
Energy dependent regulation of mTOR by LKB1-AMPK 27 6.26e-01 7.39e-01 0.12500 -9.24e-02 8.40e-02 4.06e-01 4.50e-01
Heparan sulfate/heparin (HS-GAG) metabolism 40 5.03e-01 6.31e-01 0.12400 -8.53e-02 9.04e-02 3.51e-01 3.23e-01
Regulation of NF-kappa B signaling 18 6.47e-01 7.54e-01 0.12400 -1.23e-01 1.42e-02 3.65e-01 9.17e-01
Sensory processing of sound by inner hair cells of the cochlea 54 3.79e-01 5.22e-01 0.12400 1.04e-01 -6.73e-02 1.84e-01 3.92e-01
Loss of Nlp from mitotic centrosomes 69 1.17e-01 2.30e-01 0.12400 -1.19e-01 -3.45e-02 8.67e-02 6.20e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 1.17e-01 2.30e-01 0.12400 -1.19e-01 -3.45e-02 8.67e-02 6.20e-01
Diseases of metabolism 208 9.22e-03 3.17e-02 0.12400 -1.21e-01 2.33e-02 2.52e-03 5.63e-01
G beta:gamma signalling through PLC beta 17 7.42e-01 8.30e-01 0.12300 -7.01e-02 1.02e-01 6.17e-01 4.69e-01
Presynaptic function of Kainate receptors 17 7.42e-01 8.30e-01 0.12300 -7.01e-02 1.02e-01 6.17e-01 4.69e-01
Signal regulatory protein family interactions 13 7.38e-01 8.28e-01 0.12300 -1.22e-01 1.73e-02 4.46e-01 9.14e-01
G beta:gamma signalling through CDC42 17 7.31e-01 8.22e-01 0.12300 -5.71e-02 1.09e-01 6.83e-01 4.36e-01
MAP kinase activation 63 2.92e-01 4.37e-01 0.12300 -4.62e-02 1.14e-01 5.26e-01 1.17e-01
G beta:gamma signalling through PI3Kgamma 22 5.96e-01 7.09e-01 0.12300 -1.46e-02 1.22e-01 9.06e-01 3.23e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 7.38e-01 8.28e-01 0.12300 -1.22e-01 1.57e-02 4.48e-01 9.22e-01
Respiratory syncytial virus (RSV) attachment and entry 18 5.41e-01 6.66e-01 0.12200 9.05e-02 8.18e-02 5.06e-01 5.48e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins 61 1.26e-01 2.41e-01 0.12200 -7.92e-02 -9.27e-02 2.85e-01 2.11e-01
Cellular Senescence 143 6.47e-02 1.46e-01 0.12200 -1.13e-01 4.50e-02 1.95e-02 3.53e-01
Aspirin ADME 16 7.61e-01 8.40e-01 0.12200 -6.84e-02 1.01e-01 6.36e-01 4.86e-01
Signaling by FGFR2 in disease 33 4.49e-01 5.86e-01 0.12100 -1.21e-01 5.41e-03 2.28e-01 9.57e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 6.31e-01 7.42e-01 0.12100 -2.67e-02 -1.18e-01 8.53e-01 4.13e-01
Regulation of MITF-M-dependent genes involved in pigmentation 37 4.22e-01 5.64e-01 0.12100 1.21e-01 -1.12e-02 2.05e-01 9.06e-01
CD28 dependent PI3K/Akt signaling 22 6.84e-01 7.85e-01 0.12100 1.04e-01 -6.25e-02 4.00e-01 6.12e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 18 5.74e-01 6.88e-01 0.12100 -4.46e-02 -1.12e-01 7.43e-01 4.09e-01
Cytochrome P450 - arranged by substrate type 38 4.73e-01 6.07e-01 0.12000 1.15e-01 -3.66e-02 2.21e-01 6.96e-01
Assembly of collagen fibrils and other multimeric structures 44 3.00e-01 4.44e-01 0.12000 1.19e-01 1.98e-02 1.74e-01 8.20e-01
Activation of kainate receptors upon glutamate binding 26 4.43e-01 5.82e-01 0.12000 5.41e-02 1.07e-01 6.33e-01 3.45e-01
Evasion by RSV of host interferon responses 20 6.82e-01 7.84e-01 0.12000 3.98e-02 -1.13e-01 7.58e-01 3.82e-01
N-Glycan antennae elongation 13 7.26e-01 8.18e-01 0.12000 1.46e-03 1.20e-01 9.93e-01 4.55e-01
Cellular responses to mechanical stimuli 82 1.92e-01 3.21e-01 0.12000 -3.08e-02 1.16e-01 6.30e-01 7.05e-02
Response of endothelial cells to shear stress 82 1.92e-01 3.21e-01 0.12000 -3.08e-02 1.16e-01 6.30e-01 7.05e-02
Triglyceride catabolism 16 6.68e-01 7.72e-01 0.12000 6.37e-03 1.19e-01 9.65e-01 4.09e-01
RUNX3 regulates CDKN1A transcription 7 8.93e-01 9.28e-01 0.11900 9.55e-02 -7.18e-02 6.62e-01 7.42e-01
Signaling by GPCR 442 5.47e-05 3.43e-04 0.11900 1.19e-01 -1.10e-02 1.91e-05 6.92e-01
RUNX2 regulates genes involved in cell migration 6 9.00e-01 9.30e-01 0.11900 1.07e-01 -5.24e-02 6.50e-01 8.24e-01
RHOB GTPase cycle 65 1.40e-01 2.57e-01 0.11900 4.79e-02 1.09e-01 5.05e-01 1.29e-01
Signaling by Hedgehog 120 1.05e-01 2.11e-01 0.11900 -1.12e-01 3.93e-02 3.36e-02 4.57e-01
Gap junction degradation 11 8.19e-01 8.88e-01 0.11800 -4.20e-02 1.10e-01 8.09e-01 5.28e-01
IRF3-mediated induction of type I IFN 12 8.07e-01 8.79e-01 0.11800 -1.09e-01 4.48e-02 5.14e-01 7.88e-01
PPARA activates gene expression 105 1.58e-01 2.80e-01 0.11800 4.65e-02 -1.08e-01 4.10e-01 5.57e-02
RND2 GTPase cycle 37 5.06e-01 6.34e-01 0.11700 1.11e-01 -3.88e-02 2.43e-01 6.83e-01
Regulation of signaling by NODAL 6 8.64e-01 9.14e-01 0.11700 1.17e-01 6.88e-03 6.19e-01 9.77e-01
Activated point mutants of FGFR2 7 8.80e-01 9.20e-01 0.11700 3.99e-02 -1.10e-01 8.55e-01 6.13e-01
Signaling by FGFR1 42 2.93e-01 4.37e-01 0.11700 4.59e-02 1.08e-01 6.07e-01 2.27e-01
Activated NTRK2 signals through RAS 6 8.42e-01 8.99e-01 0.11700 1.10e-01 4.10e-02 6.42e-01 8.62e-01
RHO GTPases Activate NADPH Oxidases 21 5.54e-01 6.75e-01 0.11700 1.10e-01 3.77e-02 3.81e-01 7.65e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 3.81e-01 5.23e-01 0.11600 -1.07e-01 4.61e-02 1.66e-01 5.51e-01
LDL clearance 18 7.55e-01 8.36e-01 0.11600 -9.67e-02 6.46e-02 4.78e-01 6.35e-01
Formation of WDR5-containing histone-modifying complexes 42 4.98e-01 6.27e-01 0.11600 5.19e-02 -1.04e-01 5.61e-01 2.44e-01
Negative regulation of FLT3 15 6.88e-01 7.89e-01 0.11600 -1.58e-02 -1.15e-01 9.16e-01 4.42e-01
Adaptive Immune System 768 1.33e-05 9.26e-05 0.11500 -9.22e-02 6.94e-02 1.37e-05 1.06e-03
VEGFR2 mediated cell proliferation 18 6.31e-01 7.42e-01 0.11500 -1.13e-01 -2.19e-02 4.05e-01 8.72e-01
Biosynthesis of E-series 18(S)-resolvins 5 8.72e-01 9.16e-01 0.11500 1.09e-01 3.72e-02 6.73e-01 8.85e-01
Signaling by NOTCH3 44 4.78e-01 6.11e-01 0.11500 -4.56e-02 1.05e-01 6.00e-01 2.26e-01
RET signaling 32 4.29e-01 5.70e-01 0.11400 1.09e-01 3.38e-02 2.86e-01 7.41e-01
Transmission across Chemical Synapses 188 5.75e-03 2.14e-02 0.11400 1.04e-01 4.54e-02 1.36e-02 2.84e-01
Hydrolysis of LPC 8 8.90e-01 9.25e-01 0.11300 -6.45e-02 9.25e-02 7.52e-01 6.50e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 5.62e-01 6.80e-01 0.11200 -5.48e-02 9.82e-02 5.58e-01 2.95e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8 8.54e-01 9.07e-01 0.11200 -1.36e-02 1.11e-01 9.47e-01 5.85e-01
Effects of PIP2 hydrolysis 24 5.58e-01 6.79e-01 0.11200 1.10e-01 2.22e-02 3.52e-01 8.50e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 38 5.44e-01 6.68e-01 0.11100 -1.03e-01 4.13e-02 2.70e-01 6.60e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 23 5.44e-01 6.68e-01 0.11100 -1.00e-01 -4.72e-02 4.05e-01 6.95e-01
G alpha (s) signalling events 97 2.34e-01 3.70e-01 0.11100 9.88e-02 -5.00e-02 9.27e-02 3.95e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 6.99e-01 7.96e-01 0.10900 4.41e-02 1.00e-01 7.75e-01 5.17e-01
RAC2 GTPase cycle 86 1.94e-01 3.23e-01 0.10900 1.08e-01 -7.91e-03 8.24e-02 8.99e-01
Transcriptional activation of mitochondrial biogenesis 52 4.99e-01 6.28e-01 0.10800 8.82e-02 -6.24e-02 2.71e-01 4.36e-01
Beta-oxidation of very long chain fatty acids 11 8.62e-01 9.13e-01 0.10800 -5.91e-02 9.00e-02 7.34e-01 6.05e-01
Formation of definitive endoderm 9 7.95e-01 8.68e-01 0.10700 9.35e-02 5.27e-02 6.27e-01 7.84e-01
Gamma-carboxylation of protein precursors 6 9.25e-01 9.50e-01 0.10700 6.59e-02 -8.43e-02 7.80e-01 7.21e-01
FGFR2b ligand binding and activation 6 8.70e-01 9.16e-01 0.10700 1.02e-01 3.18e-02 6.66e-01 8.93e-01
Bacterial Infection Pathways 66 4.33e-01 5.74e-01 0.10700 -7.15e-02 7.92e-02 3.15e-01 2.66e-01
Calcineurin activates NFAT 9 8.34e-01 8.94e-01 0.10700 6.80e-03 1.06e-01 9.72e-01 5.81e-01
TP53 Regulates Transcription of Cell Death Genes 43 5.59e-01 6.79e-01 0.10600 5.09e-02 -9.30e-02 5.64e-01 2.92e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 7.32e-01 8.23e-01 0.10600 8.80e-02 -5.91e-02 4.56e-01 6.17e-01
Zinc transporters 12 8.59e-01 9.10e-01 0.10600 -8.31e-02 6.55e-02 6.18e-01 6.94e-01
Blood group systems biosynthesis 18 6.47e-01 7.54e-01 0.10500 4.73e-02 9.42e-02 7.28e-01 4.89e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 5.21e-01 6.48e-01 0.10500 2.39e-02 1.02e-01 8.21e-01 3.32e-01
RHOF GTPase cycle 39 3.72e-01 5.14e-01 0.10500 7.18e-02 7.68e-02 4.38e-01 4.07e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.67e-01 6.83e-01 0.10500 -3.55e-03 1.05e-01 9.73e-01 3.13e-01
PI3K/AKT Signaling in Cancer 85 1.54e-01 2.75e-01 0.10500 1.01e-01 2.87e-02 1.09e-01 6.47e-01
Sensory perception of taste 22 6.12e-01 7.26e-01 0.10500 9.98e-02 3.13e-02 4.18e-01 7.99e-01
FGFR1 mutant receptor activation 25 5.51e-01 6.73e-01 0.10300 8.62e-02 5.65e-02 4.56e-01 6.25e-01
FGFR1 ligand binding and activation 10 8.68e-01 9.16e-01 0.10300 -3.44e-02 9.70e-02 8.51e-01 5.95e-01
CDC42 GTPase cycle 141 3.80e-02 9.87e-02 0.10300 9.00e-02 4.98e-02 6.50e-02 3.08e-01
GPCR downstream signalling 398 1.05e-03 4.90e-03 0.10300 1.03e-01 -4.10e-03 4.33e-04 8.88e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 7.73e-01 8.49e-01 0.10300 -9.98e-02 2.38e-02 4.76e-01 8.65e-01
RND3 GTPase cycle 36 4.33e-01 5.74e-01 0.10200 8.81e-02 5.22e-02 3.61e-01 5.88e-01
Interleukin-17 signaling 68 3.83e-01 5.26e-01 0.10200 -3.20e-02 9.71e-02 6.48e-01 1.66e-01
Acyl chain remodelling of PC 19 6.98e-01 7.96e-01 0.10200 1.02e-01 9.65e-03 4.43e-01 9.42e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 2.88e-01 4.32e-01 0.10100 -1.36e-02 1.00e-01 8.34e-01 1.24e-01
HS-GAG degradation 19 7.23e-01 8.16e-01 0.10100 -1.01e-01 2.46e-03 4.46e-01 9.85e-01
Class A/1 (Rhodopsin-like receptors) 175 2.27e-02 6.57e-02 0.10100 9.27e-02 4.01e-02 3.44e-02 3.60e-01
COPII-mediated vesicle transport 67 4.39e-01 5.79e-01 0.10100 -8.91e-02 4.68e-02 2.07e-01 5.08e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 4.77e-01 6.11e-01 0.10000 4.39e-02 9.00e-02 6.58e-01 3.64e-01
Oncogenic MAPK signaling 76 4.10e-01 5.54e-01 0.09990 -8.54e-02 5.19e-02 1.98e-01 4.34e-01
PI5P Regulates TP53 Acetylation 8 8.69e-01 9.16e-01 0.09960 9.95e-02 4.87e-03 6.26e-01 9.81e-01
Extra-nuclear estrogen signaling 67 4.02e-01 5.46e-01 0.09950 -2.88e-02 9.53e-02 6.83e-01 1.77e-01
Signaling by ALK fusions and activated point mutants 89 3.47e-01 4.89e-01 0.09920 8.74e-02 -4.69e-02 1.54e-01 4.44e-01
Signaling by ALK in cancer 89 3.47e-01 4.89e-01 0.09920 8.74e-02 -4.69e-02 1.54e-01 4.44e-01
Sema3A PAK dependent Axon repulsion 15 7.22e-01 8.16e-01 0.09910 8.61e-02 4.90e-02 5.64e-01 7.43e-01
Deubiquitination 225 8.69e-02 1.84e-01 0.09900 -7.45e-02 6.52e-02 5.41e-02 9.20e-02
FGFR1b ligand binding and activation 5 9.11e-01 9.38e-01 0.09880 1.78e-02 9.72e-02 9.45e-01 7.07e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 8.10e-01 8.80e-01 0.09880 -3.93e-03 9.87e-02 9.80e-01 5.38e-01
Regulation of TP53 Activity 153 8.46e-02 1.80e-01 0.09870 -9.87e-02 3.07e-03 3.52e-02 9.48e-01
Signaling by SCF-KIT 40 4.50e-01 5.87e-01 0.09860 9.36e-02 3.09e-02 3.05e-01 7.35e-01
Signaling by FGFR 73 4.54e-01 5.90e-01 0.09860 -7.25e-02 6.68e-02 2.84e-01 3.24e-01
RHO GTPases activate KTN1 11 7.83e-01 8.58e-01 0.09850 6.43e-02 7.47e-02 7.12e-01 6.68e-01
Attachment and Entry 9694614 14 8.44e-01 9.01e-01 0.09850 4.19e-02 -8.92e-02 7.86e-01 5.63e-01
Ovarian tumor domain proteases 37 4.87e-01 6.18e-01 0.09850 9.50e-02 2.59e-02 3.17e-01 7.85e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 8.21e-01 8.90e-01 0.09850 -9.77e-02 -1.20e-02 5.75e-01 9.45e-01
Glucose metabolism 76 1.87e-01 3.15e-01 0.09820 -7.31e-02 -6.56e-02 2.71e-01 3.23e-01
Biosynthesis of DHA-derived SPMs 15 8.52e-01 9.07e-01 0.09780 7.12e-02 -6.71e-02 6.33e-01 6.53e-01
Metabolism of carbohydrates 241 3.76e-02 9.82e-02 0.09770 -9.51e-02 2.24e-02 1.10e-02 5.49e-01
Respiratory Syncytial Virus Infection Pathway 99 2.12e-01 3.45e-01 0.09740 -9.74e-02 4.10e-03 9.41e-02 9.44e-01
FOXO-mediated transcription of cell cycle genes 15 7.24e-01 8.17e-01 0.09740 7.82e-02 5.81e-02 6.00e-01 6.97e-01
RSV-host interactions 78 1.92e-01 3.21e-01 0.09740 -5.16e-02 -8.26e-02 4.31e-01 2.07e-01
Small interfering RNA (siRNA) biogenesis 9 8.22e-01 8.91e-01 0.09730 6.88e-02 6.87e-02 7.21e-01 7.21e-01
SUMOylation of intracellular receptors 26 7.50e-01 8.33e-01 0.09710 8.25e-02 -5.11e-02 4.66e-01 6.52e-01
Arachidonate metabolism 45 6.15e-01 7.28e-01 0.09690 -5.48e-02 8.00e-02 5.25e-01 3.53e-01
Integration of energy metabolism 88 1.71e-01 2.96e-01 0.09690 8.84e-02 3.97e-02 1.52e-01 5.20e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 4.42e-01 5.82e-01 0.09680 9.63e-02 -9.92e-03 2.17e-01 8.99e-01
Visual phototransduction 60 5.10e-01 6.38e-01 0.09670 -4.69e-02 8.46e-02 5.30e-01 2.57e-01
Listeria monocytogenes entry into host cells 17 8.11e-01 8.81e-01 0.09630 -9.07e-02 3.22e-02 5.17e-01 8.18e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 7.60e-01 8.39e-01 0.09600 -4.29e-03 -9.59e-02 9.76e-01 4.94e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 7.60e-01 8.39e-01 0.09600 -4.29e-03 -9.59e-02 9.76e-01 4.94e-01
FRS-mediated FGFR4 signaling 13 7.63e-01 8.42e-01 0.09530 7.22e-02 6.22e-02 6.52e-01 6.98e-01
Developmental Biology 929 8.66e-05 5.17e-04 0.09520 -7.92e-02 5.29e-02 4.27e-05 6.28e-03
SHC-mediated cascade:FGFR3 10 8.51e-01 9.06e-01 0.09520 6.43e-03 9.49e-02 9.72e-01 6.03e-01
SUMOylation of immune response proteins 12 8.73e-01 9.16e-01 0.09500 3.97e-02 -8.64e-02 8.12e-01 6.04e-01
Anchoring of the basal body to the plasma membrane 97 1.39e-01 2.56e-01 0.09500 -5.43e-02 -7.80e-02 3.55e-01 1.84e-01
Growth hormone receptor signaling 21 6.73e-01 7.77e-01 0.09470 8.84e-02 3.41e-02 4.83e-01 7.87e-01
Acyl chain remodelling of PE 20 7.91e-01 8.64e-01 0.09450 -8.83e-02 3.37e-02 4.94e-01 7.94e-01
Signaling by Non-Receptor Tyrosine Kinases 47 6.29e-01 7.41e-01 0.09420 -6.81e-02 6.51e-02 4.20e-01 4.40e-01
Signaling by PTK6 47 6.29e-01 7.41e-01 0.09420 -6.81e-02 6.51e-02 4.20e-01 4.40e-01
Signaling by TGF-beta Receptor Complex 91 2.83e-01 4.26e-01 0.09420 -1.09e-02 9.36e-02 8.57e-01 1.23e-01
Nuclear Envelope Breakdown 53 3.54e-01 4.97e-01 0.09410 -8.14e-02 -4.72e-02 3.05e-01 5.52e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 19 6.80e-01 7.83e-01 0.09400 6.48e-02 6.80e-02 6.25e-01 6.08e-01
CD28 co-stimulation 33 6.88e-01 7.89e-01 0.09340 8.68e-02 -3.44e-02 3.88e-01 7.32e-01
Pre-NOTCH Expression and Processing 63 3.90e-01 5.33e-01 0.09330 1.47e-03 9.33e-02 9.84e-01 2.00e-01
Sensory processing of sound 58 5.19e-01 6.46e-01 0.09330 8.69e-02 -3.39e-02 2.52e-01 6.55e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 17 8.25e-01 8.92e-01 0.09310 -3.36e-02 8.68e-02 8.11e-01 5.36e-01
TNF signaling 56 5.85e-01 6.98e-01 0.09250 5.94e-02 -7.09e-02 4.42e-01 3.59e-01
Carboxyterminal post-translational modifications of tubulin 34 7.25e-01 8.17e-01 0.09220 -6.84e-02 6.18e-02 4.90e-01 5.33e-01
Biosynthesis of specialized proresolving mediators (SPMs) 17 7.51e-01 8.33e-01 0.09210 8.94e-02 2.21e-02 5.23e-01 8.74e-01
Sialic acid metabolism 28 7.67e-01 8.43e-01 0.09210 6.24e-02 -6.78e-02 5.68e-01 5.35e-01
Nucleotide-like (purinergic) receptors 13 8.85e-01 9.23e-01 0.09180 6.24e-02 -6.74e-02 6.97e-01 6.74e-01
Regulation of TNFR1 signaling 47 6.31e-01 7.42e-01 0.09150 7.77e-02 -4.83e-02 3.57e-01 5.67e-01
FRS-mediated FGFR2 signaling 15 7.85e-01 8.59e-01 0.09140 8.96e-02 1.81e-02 5.48e-01 9.04e-01
ADP signalling through P2Y purinoceptor 1 21 8.00e-01 8.72e-01 0.09110 -3.50e-02 8.41e-02 7.81e-01 5.05e-01
FasL/ CD95L signaling 5 9.09e-01 9.38e-01 0.09090 6.32e-02 6.54e-02 8.07e-01 8.00e-01
Nuclear signaling by ERBB4 24 6.40e-01 7.47e-01 0.09020 -6.83e-02 -5.89e-02 5.63e-01 6.17e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 108 1.94e-01 3.23e-01 0.09020 -1.31e-02 -8.92e-02 8.15e-01 1.09e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 8.87e-01 9.24e-01 0.08990 8.31e-02 3.43e-02 7.03e-01 8.75e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 9 8.76e-01 9.16e-01 0.08990 -9.36e-03 -8.94e-02 9.61e-01 6.42e-01
Downstream signal transduction 27 7.19e-01 8.13e-01 0.08910 8.82e-02 -1.25e-02 4.28e-01 9.11e-01
Ephrin signaling 18 8.50e-01 9.05e-01 0.08870 5.05e-02 -7.29e-02 7.11e-01 5.92e-01
FGFR2c ligand binding and activation 5 9.56e-01 9.70e-01 0.08860 7.37e-02 -4.93e-02 7.75e-01 8.49e-01
RHOC GTPase cycle 72 3.03e-01 4.45e-01 0.08840 3.43e-02 8.15e-02 6.15e-01 2.32e-01
Pre-NOTCH Transcription and Translation 47 5.19e-01 6.46e-01 0.08820 7.15e-03 8.79e-02 9.32e-01 2.97e-01
Signaling by EGFR in Cancer 23 6.94e-01 7.93e-01 0.08680 8.07e-02 3.21e-02 5.03e-01 7.90e-01
TCF dependent signaling in response to WNT 153 2.81e-01 4.23e-01 0.08650 -5.77e-02 6.45e-02 2.18e-01 1.68e-01
Lysine catabolism 11 8.29e-01 8.92e-01 0.08620 -6.33e-02 -5.85e-02 7.16e-01 7.37e-01
Eicosanoid ligand-binding receptors 13 8.72e-01 9.16e-01 0.08570 -8.33e-02 2.02e-02 6.03e-01 9.00e-01
Ion homeostasis 42 7.06e-01 8.01e-01 0.08540 6.82e-02 -5.15e-02 4.44e-01 5.64e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 8.33e-01 8.94e-01 0.08500 1.70e-03 -8.50e-02 9.91e-01 5.69e-01
Signaling by Activin 14 8.76e-01 9.16e-01 0.08470 -2.89e-02 7.96e-02 8.51e-01 6.06e-01
RUNX2 regulates osteoblast differentiation 21 7.74e-01 8.49e-01 0.08400 8.39e-02 1.99e-03 5.05e-01 9.87e-01
VEGFA-VEGFR2 Pathway 93 4.45e-01 5.83e-01 0.08370 -3.56e-02 7.57e-02 5.53e-01 2.07e-01
RAF activation 33 7.56e-01 8.37e-01 0.08340 -3.86e-02 7.39e-02 7.01e-01 4.63e-01
Loss of Function of TGFBR1 in Cancer 7 9.46e-01 9.65e-01 0.08280 -6.89e-02 4.60e-02 7.52e-01 8.33e-01
Negative regulation of MAPK pathway 42 7.19e-01 8.13e-01 0.08280 -4.76e-02 6.78e-02 5.93e-01 4.47e-01
SHC-mediated cascade:FGFR2 13 8.99e-01 9.30e-01 0.08270 7.22e-02 -4.04e-02 6.52e-01 8.01e-01
Reduction of cytosolic Ca++ levels 9 8.80e-01 9.20e-01 0.08220 2.89e-02 7.69e-02 8.81e-01 6.89e-01
RA biosynthesis pathway 13 8.28e-01 8.92e-01 0.08200 -3.43e-02 -7.45e-02 8.30e-01 6.42e-01
Stimuli-sensing channels 81 5.00e-01 6.28e-01 0.08180 7.55e-02 -3.16e-02 2.40e-01 6.23e-01
Signaling by WNT 241 1.42e-01 2.60e-01 0.08160 -3.67e-02 7.28e-02 3.27e-01 5.14e-02
Muscle contraction 145 1.18e-01 2.31e-01 0.08160 6.96e-02 4.24e-02 1.48e-01 3.78e-01
Regulation of endogenous retroelements 92 2.48e-01 3.89e-01 0.08150 -6.22e-02 -5.26e-02 3.02e-01 3.83e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 7.64e-01 8.42e-01 0.08060 1.23e-02 7.96e-02 9.21e-01 5.18e-01
Signaling by VEGF 100 4.87e-01 6.18e-01 0.08050 -5.88e-02 5.49e-02 3.09e-01 3.42e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 6.82e-01 7.83e-01 0.07980 2.84e-02 -7.46e-02 7.39e-01 3.81e-01
G alpha (12/13) signalling events 68 5.14e-01 6.43e-01 0.07950 7.88e-02 -1.04e-02 2.61e-01 8.82e-01
Death Receptor Signaling 145 3.63e-01 5.05e-01 0.07940 5.33e-02 -5.88e-02 2.68e-01 2.22e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 81 4.55e-01 5.90e-01 0.07930 7.86e-02 -1.03e-02 2.21e-01 8.72e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 8.66e-01 9.15e-01 0.07890 -7.87e-02 -4.97e-03 6.23e-01 9.75e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 6 9.37e-01 9.59e-01 0.07870 7.87e-02 2.32e-03 7.39e-01 9.92e-01
Scavenging by Class F Receptors 5 9.55e-01 9.70e-01 0.07870 1.41e-02 -7.74e-02 9.56e-01 7.64e-01
FGFR3 ligand binding and activation 5 9.65e-01 9.75e-01 0.07830 6.56e-02 -4.28e-02 8.00e-01 8.68e-01
FGFR3c ligand binding and activation 5 9.65e-01 9.75e-01 0.07830 6.56e-02 -4.28e-02 8.00e-01 8.68e-01
Post-translational protein phosphorylation 70 5.73e-01 6.88e-01 0.07770 -2.67e-02 7.30e-02 7.00e-01 2.91e-01
Gene expression (Transcription) 1413 1.32e-08 1.46e-07 0.07760 -4.73e-02 -6.15e-02 2.91e-03 1.06e-04
Metal ion SLC transporters 19 8.33e-01 8.94e-01 0.07730 -5.80e-03 7.71e-02 9.65e-01 5.61e-01
RAB GEFs exchange GTP for GDP on RABs 89 4.88e-01 6.18e-01 0.07720 -2.38e-02 7.35e-02 6.98e-01 2.31e-01
RHOD GTPase cycle 50 5.47e-01 6.70e-01 0.07700 2.27e-02 7.36e-02 7.82e-01 3.68e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.32e-01 9.54e-01 0.07690 7.45e-02 1.92e-02 7.52e-01 9.35e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 6 9.32e-01 9.54e-01 0.07690 7.45e-02 1.92e-02 7.52e-01 9.35e-01
Platelet homeostasis 69 5.49e-01 6.71e-01 0.07660 -1.46e-02 7.52e-02 8.34e-01 2.80e-01
Transcription of E2F targets under negative control by DREAM complex 19 7.89e-01 8.62e-01 0.07650 -7.03e-02 -3.03e-02 5.96e-01 8.19e-01
Formation of the beta-catenin:TCF transactivating complex 44 7.16e-01 8.11e-01 0.07640 -2.77e-02 7.12e-02 7.50e-01 4.14e-01
FOXO-mediated transcription 58 4.71e-01 6.05e-01 0.07630 4.01e-02 6.50e-02 5.97e-01 3.92e-01
C-type lectin receptors (CLRs) 118 3.25e-01 4.67e-01 0.07630 -7.62e-02 3.99e-03 1.53e-01 9.40e-01
NOD1/2 Signaling Pathway 36 7.06e-01 8.01e-01 0.07630 7.62e-02 -2.63e-03 4.29e-01 9.78e-01
RAF/MAP kinase cascade 226 2.27e-01 3.63e-01 0.07620 -4.48e-02 6.16e-02 2.46e-01 1.11e-01
RNA Polymerase II Transcription 1206 4.11e-07 3.56e-06 0.07610 -3.90e-02 -6.53e-02 2.24e-02 1.34e-04
Toll Like Receptor 4 (TLR4) Cascade 138 3.32e-01 4.74e-01 0.07610 7.30e-02 -2.12e-02 1.38e-01 6.67e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.40e-01 8.99e-01 0.07580 -6.80e-02 -3.35e-02 6.59e-01 8.28e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.40e-01 8.99e-01 0.07580 -6.80e-02 -3.35e-02 6.59e-01 8.28e-01
Phospholipid metabolism 183 2.14e-01 3.46e-01 0.07540 7.42e-02 -1.37e-02 8.35e-02 7.49e-01
Transport of small molecules 558 3.03e-02 8.27e-02 0.07460 -6.17e-02 4.20e-02 1.28e-02 8.97e-02
Epithelial-Mesenchymal Transition (EMT) during gastrulation 6 9.41e-01 9.62e-01 0.07450 -7.44e-03 -7.42e-02 9.75e-01 7.53e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 624 1.71e-02 5.21e-02 0.07430 -3.50e-02 6.56e-02 1.36e-01 5.15e-03
Generic Transcription Pathway 1088 7.82e-06 5.66e-05 0.07430 -2.33e-02 -7.06e-02 1.95e-01 8.40e-05
Lewis blood group biosynthesis 14 8.40e-01 8.99e-01 0.07370 5.55e-02 4.86e-02 7.19e-01 7.53e-01
MAPK1/MAPK3 signaling 232 2.32e-01 3.68e-01 0.07370 -3.93e-02 6.24e-02 3.02e-01 1.02e-01
Glycolysis 68 4.71e-01 6.05e-01 0.07340 -6.95e-02 -2.36e-02 3.22e-01 7.37e-01
Acyl chain remodelling of PS 14 8.76e-01 9.16e-01 0.07300 7.28e-02 4.73e-03 6.37e-01 9.76e-01
Extracellular matrix organization 222 8.03e-02 1.74e-01 0.07260 3.22e-02 6.51e-02 4.09e-01 9.46e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.74e-01 9.16e-01 0.07260 -2.85e-02 -6.68e-02 8.64e-01 6.89e-01
alpha-linolenic acid (ALA) metabolism 12 8.74e-01 9.16e-01 0.07260 -2.85e-02 -6.68e-02 8.64e-01 6.89e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 8.45e-01 9.02e-01 0.07250 5.44e-02 4.79e-02 7.25e-01 7.56e-01
CaMK IV-mediated phosphorylation of CREB 9 9.46e-01 9.65e-01 0.07250 3.91e-02 -6.10e-02 8.39e-01 7.51e-01
RIPK1-mediated regulated necrosis 31 7.05e-01 8.01e-01 0.07230 6.54e-02 3.08e-02 5.29e-01 7.66e-01
Regulation of necroptotic cell death 31 7.05e-01 8.01e-01 0.07230 6.54e-02 3.08e-02 5.29e-01 7.66e-01
RUNX2 regulates bone development 26 7.46e-01 8.30e-01 0.07010 4.92e-02 4.99e-02 6.64e-01 6.60e-01
Serine biosynthesis 8 9.17e-01 9.42e-01 0.07000 3.43e-02 6.11e-02 8.67e-01 7.65e-01
Sensory processing of sound by outer hair cells of the cochlea 41 6.35e-01 7.44e-01 0.07000 5.66e-02 4.11e-02 5.31e-01 6.49e-01
SHC1 events in ERBB2 signaling 17 8.27e-01 8.92e-01 0.06970 4.66e-02 5.19e-02 7.40e-01 7.11e-01
Integrin cell surface interactions 68 4.74e-01 6.07e-01 0.06930 4.82e-02 4.98e-02 4.92e-01 4.78e-01
STING mediated induction of host immune responses 15 8.53e-01 9.07e-01 0.06910 -3.46e-02 -5.98e-02 8.16e-01 6.89e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 8.93e-01 9.28e-01 0.06900 6.47e-02 -2.40e-02 6.35e-01 8.60e-01
Immune System 1841 1.37e-04 7.85e-04 0.06880 -4.81e-02 4.92e-02 6.29e-04 4.62e-04
Ion channel transport 141 3.87e-01 5.30e-01 0.06880 6.68e-02 -1.62e-02 1.71e-01 7.39e-01
Toll-like Receptor Cascades 162 4.27e-01 5.69e-01 0.06880 5.22e-02 -4.47e-02 2.51e-01 3.26e-01
Chromatin modifying enzymes 215 3.24e-01 4.66e-01 0.06880 4.53e-02 -5.17e-02 2.52e-01 1.91e-01
Chromatin organization 215 3.24e-01 4.66e-01 0.06880 4.53e-02 -5.17e-02 2.52e-01 1.91e-01
Inflammasomes 21 8.88e-01 9.25e-01 0.06860 5.98e-02 -3.36e-02 6.35e-01 7.90e-01
Glycosaminoglycan metabolism 98 5.80e-01 6.93e-01 0.06790 -3.20e-02 5.99e-02 5.85e-01 3.06e-01
Pre-NOTCH Processing in Golgi 18 8.74e-01 9.16e-01 0.06760 6.75e-02 -3.74e-03 6.20e-01 9.78e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 5.19e-01 6.46e-01 0.06750 -3.10e-02 -5.99e-02 6.63e-01 4.00e-01
Glycerophospholipid biosynthesis 105 5.89e-01 7.01e-01 0.06740 -5.02e-02 4.49e-02 3.74e-01 4.26e-01
CRMPs in Sema3A signaling 13 8.82e-01 9.20e-01 0.06730 6.15e-02 2.73e-02 7.01e-01 8.65e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 8.34e-01 8.95e-01 0.06710 -6.68e-02 5.32e-03 5.63e-01 9.63e-01
SLC transporter disorders 77 5.04e-01 6.31e-01 0.06630 -1.92e-02 -6.35e-02 7.71e-01 3.36e-01
Signaling by NTRKs 117 3.16e-01 4.59e-01 0.06600 5.36e-02 3.86e-02 3.16e-01 4.71e-01
FLT3 Signaling 38 7.58e-01 8.39e-01 0.06580 6.58e-02 -1.02e-03 4.83e-01 9.91e-01
Signaling by Rho GTPases 608 4.09e-02 1.03e-01 0.06580 -2.79e-02 5.96e-02 2.40e-01 1.21e-02
RAF-independent MAPK1/3 activation 22 8.12e-01 8.82e-01 0.06520 3.33e-02 5.61e-02 7.87e-01 6.49e-01
Signaling by Receptor Tyrosine Kinases 449 5.00e-02 1.21e-01 0.06510 -5.43e-03 6.49e-02 8.44e-01 1.85e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 8.98e-01 9.29e-01 0.06440 -1.43e-02 6.28e-02 9.16e-01 6.45e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 8.98e-01 9.29e-01 0.06440 -1.43e-02 6.28e-02 9.16e-01 6.45e-01
Epigenetic regulation by WDR5-containing histone modifying complexes 117 5.60e-01 6.79e-01 0.06410 -3.02e-02 5.65e-02 5.72e-01 2.91e-01
ESR-mediated signaling 160 4.75e-01 6.08e-01 0.06340 -3.42e-02 5.34e-02 4.55e-01 2.44e-01
Nitric oxide stimulates guanylate cyclase 15 8.86e-01 9.23e-01 0.06260 -5.92e-02 -2.03e-02 6.92e-01 8.92e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 8.67e-01 9.16e-01 0.06250 -1.99e-02 5.93e-02 8.58e-01 5.94e-01
Regulated Necrosis 56 6.31e-01 7.42e-01 0.06250 -5.83e-02 -2.27e-02 4.51e-01 7.69e-01
FOXO-mediated transcription of cell death genes 16 8.71e-01 9.16e-01 0.06230 3.14e-02 5.38e-02 8.28e-01 7.09e-01
Intra-Golgi traffic 43 8.26e-01 8.92e-01 0.06200 -3.42e-02 5.17e-02 6.98e-01 5.58e-01
G alpha (i) signalling events 194 2.10e-01 3.42e-01 0.06150 2.53e-02 5.60e-02 5.44e-01 1.78e-01
Loss of Function of SMAD2/3 in Cancer 7 9.67e-01 9.76e-01 0.06090 5.66e-02 -2.24e-02 7.95e-01 9.18e-01
Acyl chain remodelling of PG 11 9.17e-01 9.42e-01 0.06060 5.51e-02 2.53e-02 7.52e-01 8.85e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 7.02e-01 7.99e-01 0.06000 5.99e-02 3.02e-03 4.38e-01 9.69e-01
Tie2 Signaling 16 8.83e-01 9.21e-01 0.05990 5.39e-02 2.61e-02 7.09e-01 8.56e-01
MyD88-independent TLR4 cascade 108 5.58e-01 6.79e-01 0.05910 5.86e-02 -7.64e-03 2.92e-01 8.91e-01
TRIF (TICAM1)-mediated TLR4 signaling 108 5.58e-01 6.79e-01 0.05910 5.86e-02 -7.64e-03 2.92e-01 8.91e-01
Signalling to RAS 19 9.01e-01 9.31e-01 0.05900 5.86e-02 -6.64e-03 6.58e-01 9.60e-01
Uptake and actions of bacterial toxins 28 8.99e-01 9.30e-01 0.05790 3.55e-02 -4.58e-02 7.45e-01 6.75e-01
Signaling by CSF3 (G-CSF) 29 8.05e-01 8.77e-01 0.05750 4.67e-02 3.35e-02 6.63e-01 7.55e-01
WNT mediated activation of DVL 8 9.47e-01 9.65e-01 0.05710 5.38e-02 1.92e-02 7.92e-01 9.25e-01
RHOA GTPase cycle 139 3.63e-01 5.05e-01 0.05710 3.18e-02 4.74e-02 5.18e-01 3.35e-01
Opioid Signalling 75 6.38e-01 7.46e-01 0.05700 5.66e-02 6.99e-03 3.97e-01 9.17e-01
Molecules associated with elastic fibres 26 8.30e-01 8.92e-01 0.05700 -2.81e-02 -4.96e-02 8.04e-01 6.62e-01
RAC3 GTPase cycle 88 5.22e-01 6.48e-01 0.05690 3.80e-02 4.24e-02 5.38e-01 4.92e-01
AKT phosphorylates targets in the cytosol 14 9.34e-01 9.57e-01 0.05650 -5.58e-02 8.91e-03 7.18e-01 9.54e-01
Relaxin receptors 5 9.69e-01 9.76e-01 0.05510 5.25e-02 1.68e-02 8.39e-01 9.48e-01
Platelet calcium homeostasis 22 9.07e-01 9.36e-01 0.05510 -1.16e-02 5.39e-02 9.25e-01 6.62e-01
Signaling by NOTCH1 68 7.89e-01 8.62e-01 0.05490 4.58e-02 -3.02e-02 5.13e-01 6.67e-01
Elevation of cytosolic Ca2+ levels 13 9.57e-01 9.70e-01 0.05490 -3.97e-02 3.79e-02 8.04e-01 8.13e-01
RHO GTPase cycle 412 1.19e-01 2.33e-01 0.05490 5.48e-02 2.05e-03 5.63e-02 9.43e-01
Rab regulation of trafficking 122 6.38e-01 7.46e-01 0.05450 -2.32e-02 4.93e-02 6.58e-01 3.47e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 9.58e-01 9.70e-01 0.05440 4.80e-02 -2.55e-02 7.73e-01 8.78e-01
Nicotinate metabolism 26 9.18e-01 9.43e-01 0.05390 3.35e-02 -4.22e-02 7.68e-01 7.10e-01
FGFR4 ligand binding and activation 5 9.69e-01 9.76e-01 0.05330 -2.52e-02 -4.69e-02 9.22e-01 8.56e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.46e-01 9.65e-01 0.05250 5.76e-03 5.22e-02 9.74e-01 7.65e-01
Signaling by Interleukins 391 9.42e-02 1.94e-01 0.05220 4.27e-02 2.99e-02 1.47e-01 3.10e-01
Signaling by TGFB family members 139 4.43e-01 5.82e-01 0.05160 4.48e-02 2.56e-02 3.62e-01 6.03e-01
Keratan sulfate/keratin metabolism 28 8.67e-01 9.16e-01 0.05140 1.03e-02 5.04e-02 9.25e-01 6.45e-01
Peptide hormone metabolism 54 8.55e-01 9.08e-01 0.05110 3.75e-02 -3.46e-02 6.33e-01 6.60e-01
MAPK family signaling cascades 264 3.69e-01 5.10e-01 0.05110 -1.05e-02 5.00e-02 7.68e-01 1.62e-01
ERK/MAPK targets 22 9.16e-01 9.42e-01 0.05060 -6.08e-03 5.02e-02 9.61e-01 6.83e-01
Glucagon-type ligand receptors 20 9.42e-01 9.63e-01 0.05020 -2.58e-02 4.30e-02 8.41e-01 7.39e-01
Toll Like Receptor 3 (TLR3) Cascade 104 6.70e-01 7.74e-01 0.04990 4.95e-02 -6.46e-03 3.83e-01 9.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 5.69e-01 6.84e-01 0.04970 4.60e-02 1.90e-02 4.09e-01 7.33e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 5.69e-01 6.84e-01 0.04970 4.60e-02 1.90e-02 4.09e-01 7.33e-01
Signaling by NOTCH2 33 8.94e-01 9.28e-01 0.04970 1.43e-02 -4.76e-02 8.87e-01 6.36e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 55 7.45e-01 8.30e-01 0.04940 -4.37e-02 -2.31e-02 5.75e-01 7.67e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 55 7.45e-01 8.30e-01 0.04940 -4.37e-02 -2.31e-02 5.75e-01 7.67e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 55 7.45e-01 8.30e-01 0.04940 -4.37e-02 -2.31e-02 5.75e-01 7.67e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 55 7.45e-01 8.30e-01 0.04940 -4.37e-02 -2.31e-02 5.75e-01 7.67e-01
Signaling by NOTCH1 in Cancer 55 7.45e-01 8.30e-01 0.04940 -4.37e-02 -2.31e-02 5.75e-01 7.67e-01
Signaling by ERBB2 44 8.89e-01 9.25e-01 0.04860 -2.95e-02 3.87e-02 7.35e-01 6.57e-01
SHC-mediated cascade:FGFR4 11 9.56e-01 9.70e-01 0.04840 4.84e-02 1.04e-03 7.81e-01 9.95e-01
Elastic fibre formation 33 9.12e-01 9.39e-01 0.04820 2.34e-02 -4.22e-02 8.16e-01 6.75e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 7.16e-01 8.11e-01 0.04820 4.69e-02 -1.08e-02 4.17e-01 8.51e-01
Metabolism of fat-soluble vitamins 28 9.15e-01 9.42e-01 0.04810 -4.59e-02 1.44e-02 6.74e-01 8.95e-01
Epigenetic regulation of gene expression 263 2.66e-01 4.08e-01 0.04780 -4.06e-02 -2.52e-02 2.57e-01 4.82e-01
MyD88 dependent cascade initiated on endosome 101 7.35e-01 8.25e-01 0.04770 4.52e-02 -1.51e-02 4.32e-01 7.93e-01
PIP3 activates AKT signaling 235 4.84e-01 6.16e-01 0.04740 -4.56e-02 1.33e-02 2.29e-01 7.26e-01
Metabolism of lipids 642 8.67e-02 1.83e-01 0.04710 -4.70e-02 -2.61e-03 4.21e-02 9.10e-01
MITF-M-dependent gene expression 83 7.68e-01 8.43e-01 0.04690 4.58e-02 -1.03e-02 4.71e-01 8.72e-01
Diseases of glycosylation 109 6.68e-01 7.72e-01 0.04670 -4.67e-02 -3.52e-05 4.00e-01 9.99e-01
RND1 GTPase cycle 37 8.70e-01 9.16e-01 0.04630 1.92e-03 4.63e-02 9.84e-01 6.26e-01
Toll Like Receptor 9 (TLR9) Cascade 108 7.55e-01 8.36e-01 0.04620 4.11e-02 -2.12e-02 4.61e-01 7.04e-01
Alpha-protein kinase 1 signaling pathway 11 9.61e-01 9.72e-01 0.04540 -4.54e-02 -2.30e-03 7.94e-01 9.89e-01
Factors involved in megakaryocyte development and platelet production 129 5.64e-01 6.81e-01 0.04530 2.02e-02 4.06e-02 6.92e-01 4.26e-01
TBC/RABGAPs 45 8.65e-01 9.14e-01 0.04510 -4.52e-03 4.49e-02 9.58e-01 6.02e-01
Synthesis of PA 31 9.06e-01 9.35e-01 0.04510 5.31e-03 -4.48e-02 9.59e-01 6.66e-01
Signaling by NTRK1 (TRKA) 102 6.64e-01 7.70e-01 0.04480 4.31e-02 1.22e-02 4.52e-01 8.32e-01
Activation of NMDA receptors and postsynaptic events 74 7.18e-01 8.13e-01 0.04420 3.09e-02 3.17e-02 6.46e-01 6.38e-01
Retrograde transport at the Trans-Golgi-Network 49 8.08e-01 8.79e-01 0.04420 -3.80e-02 -2.27e-02 6.46e-01 7.83e-01
Signaling by FGFR in disease 52 8.23e-01 8.91e-01 0.04410 -4.33e-02 -8.51e-03 5.89e-01 9.15e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 105 7.48e-01 8.31e-01 0.04350 4.26e-02 -8.94e-03 4.51e-01 8.74e-01
Synthesis of UDP-N-acetyl-glucosamine 8 9.70e-01 9.77e-01 0.04320 1.25e-02 4.14e-02 9.51e-01 8.39e-01
Retinoid metabolism and transport 25 9.43e-01 9.64e-01 0.04190 3.94e-02 -1.40e-02 7.33e-01 9.03e-01
Collagen formation 66 8.76e-01 9.16e-01 0.04170 3.47e-02 -2.31e-02 6.26e-01 7.45e-01
IKK complex recruitment mediated by RIP1 23 9.51e-01 9.68e-01 0.04130 -1.58e-02 3.82e-02 8.95e-01 7.51e-01
p75 NTR receptor-mediated signalling 89 7.33e-01 8.24e-01 0.04110 -3.89e-02 -1.33e-02 5.26e-01 8.28e-01
Caspase activation via Dependence Receptors in the absence of ligand 9 9.68e-01 9.76e-01 0.04100 -3.70e-02 -1.78e-02 8.48e-01 9.26e-01
Toll Like Receptor 2 (TLR2) Cascade 109 6.96e-01 7.94e-01 0.04090 3.95e-02 1.06e-02 4.76e-01 8.49e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 6.96e-01 7.94e-01 0.04090 3.95e-02 1.06e-02 4.76e-01 8.49e-01
TAK1-dependent IKK and NF-kappa-B activation 43 9.26e-01 9.50e-01 0.04000 2.52e-02 -3.10e-02 7.75e-01 7.25e-01
Signal Transduction 2058 1.77e-03 7.73e-03 0.03850 2.54e-02 2.89e-02 5.75e-02 3.04e-02
SUMOylation of transcription cofactors 44 9.10e-01 9.38e-01 0.03850 -3.76e-02 8.28e-03 6.66e-01 9.24e-01
Oncogene Induced Senescence 33 8.96e-01 9.29e-01 0.03810 2.68e-02 2.71e-02 7.90e-01 7.88e-01
Formation of the nephric duct 8 9.81e-01 9.86e-01 0.03740 1.82e-04 3.74e-02 9.99e-01 8.55e-01
Post NMDA receptor activation events 64 8.29e-01 8.92e-01 0.03700 1.51e-02 3.38e-02 8.35e-01 6.40e-01
ERBB2 Regulates Cell Motility 10 9.81e-01 9.86e-01 0.03660 3.53e-02 -9.69e-03 8.47e-01 9.58e-01
p38MAPK events 13 9.67e-01 9.76e-01 0.03370 1.89e-02 2.80e-02 9.06e-01 8.61e-01
EPH-ephrin mediated repulsion of cells 43 8.95e-01 9.28e-01 0.03370 -2.13e-02 -2.60e-02 8.09e-01 7.68e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 9.55e-01 9.70e-01 0.03170 2.38e-02 2.09e-02 8.54e-01 8.72e-01
Trafficking of AMPA receptors 20 9.55e-01 9.70e-01 0.03170 2.38e-02 2.09e-02 8.54e-01 8.72e-01
Phospholipase C-mediated cascade; FGFR3 5 9.90e-01 9.93e-01 0.03130 3.01e-02 8.53e-03 9.07e-01 9.74e-01
Cargo concentration in the ER 31 9.48e-01 9.65e-01 0.02990 5.95e-03 2.93e-02 9.54e-01 7.77e-01
Inactivation of CSF3 (G-CSF) signaling 24 9.54e-01 9.70e-01 0.02950 -1.55e-02 -2.51e-02 8.96e-01 8.31e-01
MyD88 cascade initiated on plasma membrane 95 8.48e-01 9.04e-01 0.02790 1.45e-02 2.39e-02 8.07e-01 6.88e-01
Toll Like Receptor 10 (TLR10) Cascade 95 8.48e-01 9.04e-01 0.02790 1.45e-02 2.39e-02 8.07e-01 6.88e-01
Toll Like Receptor 5 (TLR5) Cascade 95 8.48e-01 9.04e-01 0.02790 1.45e-02 2.39e-02 8.07e-01 6.88e-01
VEGFR2 mediated vascular permeability 26 9.58e-01 9.70e-01 0.02780 -2.57e-02 -1.06e-02 8.21e-01 9.25e-01
Signaling by Nuclear Receptors 214 6.96e-01 7.94e-01 0.02770 -2.39e-02 -1.41e-02 5.47e-01 7.21e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 9.30e-01 9.53e-01 0.02710 -2.55e-02 -9.04e-03 7.60e-01 9.14e-01
The canonical retinoid cycle in rods (twilight vision) 9 9.86e-01 9.90e-01 0.02710 -2.45e-02 -1.14e-02 8.99e-01 9.53e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 7 9.89e-01 9.93e-01 0.02620 1.33e-02 2.25e-02 9.52e-01 9.18e-01
SLC-mediated transmembrane transport 175 8.69e-01 9.16e-01 0.02550 -1.13e-02 2.29e-02 7.97e-01 6.01e-01
MITF-M-regulated melanocyte development 113 8.80e-01 9.20e-01 0.02410 5.03e-03 2.36e-02 9.26e-01 6.65e-01
Cytokine Signaling in Immune system 670 4.39e-01 5.79e-01 0.02360 -1.44e-02 -1.87e-02 5.25e-01 4.09e-01
G-protein beta:gamma signalling 29 9.67e-01 9.76e-01 0.02240 1.37e-02 1.77e-02 8.98e-01 8.69e-01
Collagen biosynthesis and modifying enzymes 48 9.72e-01 9.78e-01 0.02200 1.96e-02 -9.93e-03 8.14e-01 9.05e-01
Phase I - Functionalization of compounds 70 9.60e-01 9.71e-01 0.02180 -9.47e-03 1.97e-02 8.91e-01 7.76e-01
Metabolism of steroids 125 9.45e-01 9.65e-01 0.01860 -6.49e-03 1.75e-02 9.00e-01 7.36e-01
Cell death signalling via NRAGE, NRIF and NADE 69 9.56e-01 9.70e-01 0.01860 -1.83e-02 -3.30e-03 7.93e-01 9.62e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 9.97e-01 9.99e-01 0.01810 -1.34e-02 1.21e-02 9.48e-01 9.53e-01
Diseases of signal transduction by growth factor receptors and second messengers 404 8.28e-01 8.92e-01 0.01740 -1.95e-03 1.73e-02 9.46e-01 5.51e-01
Intracellular signaling by second messengers 268 8.71e-01 9.16e-01 0.01660 -1.64e-02 -2.51e-03 6.43e-01 9.44e-01
Signaling by ERBB4 45 9.86e-01 9.90e-01 0.01650 -8.52e-03 1.41e-02 9.21e-01 8.70e-01
FGFR2 ligand binding and activation 9 9.98e-01 9.99e-01 0.01500 1.31e-02 -7.36e-03 9.46e-01 9.70e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 9.98e-01 9.99e-01 0.01190 3.58e-03 1.14e-02 9.88e-01 9.61e-01
TGFBR1 KD Mutants in Cancer 6 9.98e-01 9.99e-01 0.01190 3.58e-03 1.14e-02 9.88e-01 9.61e-01
Induction of Cell-Cell Fusion 8 9.99e-01 9.99e-01 0.00783 7.72e-03 -1.32e-03 9.70e-01 9.95e-01
Estrogen-dependent gene expression 97 9.99e-01 9.99e-01 0.00297 -2.33e-04 2.96e-03 9.97e-01 9.60e-01


Detailed Gene set reports


FASTK family proteins regulate processing and stability of mitochondrial RNAs
FASTK family proteins regulate processing and stability of mitochondrial RNAs
metric value
setSize 19
pMANOVA 6.31e-10
p.adjustMANOVA 8.64e-09
s.dist 1
s.crp_eos_adj -0.727
s.dex_eos_adj 0.687
p.crp_eos_adj 4.07e-08
p.dex_eos_adj 2.15e-07



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MT-ND2 -10254 9404
MT-ND1 -10175 9474
MT-ND3 -10178 8131
MT-CO2 -9586 8379
MT-ATP6 -8913 8600
MT-CYB -7733 9007
MT-CO3 -9084 7529
MT-ND4 -7514 8813
MT-ND4L -8461 7596
TBRG4 -7522 8462
MT-ND5 -6746 9069
MT-CO1 -7200 7481
FASTKD5 -2927 8254
MT-ATP8 -5196 2309

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
FASTK -3799 -1948
FASTKD2 -6872 -7524
FASTKD5 -2927 8254
MT-ATP6 -8913 8600
MT-ATP8 -5196 2309
MT-CO1 -7200 7481
MT-CO2 -9586 8379
MT-CO3 -9084 7529
MT-CYB -7733 9007
MT-ND1 -10175 9474
MT-ND2 -10254 9404
MT-ND3 -10178 8131
MT-ND4 -7514 8813
MT-ND4L -8461 7596
MT-ND5 -6746 9069
MT-ND6 634 7486
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
TBRG4 -7522 8462



Formation of the ureteric bud
Formation of the ureteric bud
metric value
setSize 5
pMANOVA 0.0043
p.adjustMANOVA 0.0168
s.dist 0.959
s.crp_eos_adj -0.492
s.dex_eos_adj 0.824
p.crp_eos_adj 0.0569
p.dex_eos_adj 0.00142



Top 20 genes
Gene crp_eos_adj dex_eos_adj
WNT11 -9086 9487
FOXC1 -7606 10223
RET -7476 7926
ITGB1 -6367 6173

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
FOXC1 -7606 10223
GREM1 5935 7769
ITGB1 -6367 6173
RET -7476 7926
WNT11 -9086 9487



Modulation by Mtb of host immune system
Modulation by Mtb of host immune system
metric value
setSize 7
pMANOVA 0.000497
p.adjustMANOVA 0.00248
s.dist 0.955
s.crp_eos_adj -0.826
s.dex_eos_adj 0.478
p.crp_eos_adj 0.000153
p.dex_eos_adj 0.0284



Top 20 genes
Gene crp_eos_adj dex_eos_adj
UBC -9921 8371
TLR2 -7509 10167
MRC1 -8237 7355
B2M -10299 5647
UBA52 -9492 3637
UBB -5641 147

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
B2M -10299 5647
MRC1 -8237 7355
RPS27A -9092 -3694
TLR2 -7509 10167
UBA52 -9492 3637
UBB -5641 147
UBC -9921 8371



Mitochondrial RNA degradation
Mitochondrial RNA degradation
metric value
setSize 25
pMANOVA 8.44e-11
p.adjustMANOVA 1.35e-09
s.dist 0.911
s.crp_eos_adj -0.684
s.dex_eos_adj 0.602
p.crp_eos_adj 3.17e-09
p.dex_eos_adj 1.91e-07



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MT-ND2 -10254 9404
MT-ND1 -10175 9474
MT-ND3 -10178 8131
MT-CO2 -9586 8379
MT-ATP6 -8913 8600
MT-CYB -7733 9007
MT-CO3 -9084 7529
MT-ND4 -7514 8813
MT-ND4L -8461 7596
TBRG4 -7522 8462
MT-ND5 -6746 9069
MT-CO1 -7200 7481
GRSF1 -9525 5527
SLIRP -9947 5291
SUPV3L1 -4502 9775
PNPT1 -6799 5002
FASTKD5 -2927 8254
MT-ATP8 -5196 2309

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
FASTK -3799 -1948
FASTKD2 -6872 -7524
FASTKD5 -2927 8254
GRSF1 -9525 5527
LRPPRC -6120 1010
MT-ATP6 -8913 8600
MT-ATP8 -5196 2309
MT-CO1 -7200 7481
MT-CO2 -9586 8379
MT-CO3 -9084 7529
MT-CYB -7733 9007
MT-ND1 -10175 9474
MT-ND2 -10254 9404
MT-ND3 -10178 8131
MT-ND4 -7514 8813
MT-ND4L -8461 7596
MT-ND5 -6746 9069
MT-ND6 634 7486
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
PNPT1 -6799 5002
REXO2 3732 -9271
SLIRP -9947 5291
SUPV3L1 -4502 9775
TBRG4 -7522 8462



Defective binding of VWF variant to GPIb:IX:V
Defective binding of VWF variant to GPIb:IX:V
metric value
setSize 7
pMANOVA 0.00146
p.adjustMANOVA 0.00656
s.dist 0.906
s.crp_eos_adj -0.544
s.dex_eos_adj 0.724
p.crp_eos_adj 0.0127
p.dex_eos_adj 0.000904



Top 20 genes
Gene crp_eos_adj dex_eos_adj
GP9 -10053 9506
GP1BB -9934 8844
VWF -9126 8432
GP1BA -7007 7170
COL1A1 -2356 8986
GP5 -552 1989

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
COL1A1 -2356 8986
COL1A2 574 5629
GP1BA -7007 7170
GP1BB -9934 8844
GP5 -552 1989
GP9 -10053 9506
VWF -9126 8432



Enhanced binding of GP1BA variant to VWF multimer:collagen
Enhanced binding of GP1BA variant to VWF multimer:collagen
metric value
setSize 7
pMANOVA 0.00146
p.adjustMANOVA 0.00656
s.dist 0.906
s.crp_eos_adj -0.544
s.dex_eos_adj 0.724
p.crp_eos_adj 0.0127
p.dex_eos_adj 0.000904



Top 20 genes
Gene crp_eos_adj dex_eos_adj
GP9 -10053 9506
GP1BB -9934 8844
VWF -9126 8432
GP1BA -7007 7170
COL1A1 -2356 8986
GP5 -552 1989

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
COL1A1 -2356 8986
COL1A2 574 5629
GP1BA -7007 7170
GP1BB -9934 8844
GP5 -552 1989
GP9 -10053 9506
VWF -9126 8432



Formation of ATP by chemiosmotic coupling
Formation of ATP by chemiosmotic coupling
metric value
setSize 20
pMANOVA 3.29e-10
p.adjustMANOVA 4.82e-09
s.dist 0.898
s.crp_eos_adj -0.853
s.dex_eos_adj 0.282
p.crp_eos_adj 3.91e-11
p.dex_eos_adj 0.029



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MT-ATP6 -8913 8600
ATP5MK -10379 6930
ATP5F1B -9412 6189
ATP5F1E -10001 4842
ATP5MC3 -8105 5373
DMAC2L -8047 4018
ATP5F1C -10016 3024
ATP5PB -9734 2953
ATP5PF -9667 2871
ATP5ME -5433 4823
ATP5MG -10104 1321
MT-ATP8 -5196 2309
ATP5F1A -9448 971
ATP5MJ -8412 958
ATP5MC2 -9310 87
ATP5PO -9870 76
ATP5MC1 -9956 62

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ATP5F1A -9448 971
ATP5F1B -9412 6189
ATP5F1C -10016 3024
ATP5F1D -7279 -3853
ATP5F1E -10001 4842
ATP5MC1 -9956 62
ATP5MC2 -9310 87
ATP5MC3 -8105 5373
ATP5ME -5433 4823
ATP5MF -8778 -1709
ATP5MG -10104 1321
ATP5MJ -8412 958
ATP5MK -10379 6930
ATP5PB -9734 2953
ATP5PD -9683 -2705
ATP5PF -9667 2871
ATP5PO -9870 76
DMAC2L -8047 4018
MT-ATP6 -8913 8600
MT-ATP8 -5196 2309



Protein repair
Protein repair
metric value
setSize 6
pMANOVA 0.00441
p.adjustMANOVA 0.0172
s.dist 0.88
s.crp_eos_adj -0.477
s.dex_eos_adj 0.74
p.crp_eos_adj 0.043
p.dex_eos_adj 0.0017



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MSRB3 -9739 8941
MSRB2 -8293 8276
TXN -7033 8504
PCMT1 -4194 7077
MSRA -2137 5315

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
MSRA -2137 5315
MSRB1 2841 6253
MSRB2 -8293 8276
MSRB3 -9739 8941
PCMT1 -4194 7077
TXN -7033 8504



MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription of neuronal ligands
metric value
setSize 5
pMANOVA 0.0121
p.adjustMANOVA 0.0394
s.dist 0.869
s.crp_eos_adj 0.468
s.dex_eos_adj -0.733
p.crp_eos_adj 0.0702
p.dex_eos_adj 0.00453



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MECP2 9511 -9602
SIN3A 10425 -8347
HDAC1 2429 -11446
DLL1 2834 -7885
CREB1 2947 -6732

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
CREB1 2947 -6732
DLL1 2834 -7885
HDAC1 2429 -11446
MECP2 9511 -9602
SIN3A 10425 -8347



tRNA processing in the mitochondrion
tRNA processing in the mitochondrion
metric value
setSize 24
pMANOVA 3.66e-09
p.adjustMANOVA 4.36e-08
s.dist 0.851
s.crp_eos_adj -0.636
s.dex_eos_adj 0.566
p.crp_eos_adj 6.94e-08
p.dex_eos_adj 1.57e-06



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MT-ND2 -10254 9404
MT-ND1 -10175 9474
MT-ND3 -10178 8131
MT-CO2 -9586 8379
MT-ATP6 -8913 8600
MT-CYB -7733 9007
MT-CO3 -9084 7529
MT-ND4 -7514 8813
MT-ND4L -8461 7596
MT-ND5 -6746 9069
MT-CO1 -7200 7481
PRORP -6414 8022
MT-TC -4292 4735
ELAC2 -6478 2660
MT-TA -2526 5636
MT-ATP8 -5196 2309
TRMT10C -7180 565
MT-TP -2202 1788

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ELAC2 -6478 2660
HSD17B10 -7811 -2666
MT-ATP6 -8913 8600
MT-ATP8 -5196 2309
MT-CO1 -7200 7481
MT-CO2 -9586 8379
MT-CO3 -9084 7529
MT-CYB -7733 9007
MT-ND1 -10175 9474
MT-ND2 -10254 9404
MT-ND3 -10178 8131
MT-ND4 -7514 8813
MT-ND4L -8461 7596
MT-ND5 -6746 9069
MT-ND6 634 7486
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
MT-TA -2526 5636
MT-TC -4292 4735
MT-TN 1264 -2871
MT-TP -2202 1788
PRORP -6414 8022
TRMT10C -7180 565
TRNT1 1121 -8504



RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Opening
metric value
setSize 17
pMANOVA 1.03e-06
p.adjustMANOVA 8.36e-06
s.dist 0.844
s.crp_eos_adj -0.676
s.dex_eos_adj 0.506
p.crp_eos_adj 1.39e-06
p.dex_eos_adj 0.000301



Top 20 genes
Gene crp_eos_adj dex_eos_adj
H2AC6 -10474 9891
H2BC21 -10432 9790
H2BC11 -10259 9781
H2BC12 -10074 9601
H2BC4 -9769 9809
H2BC9 -9291 9901
H2BC5 -9558 9491
H2BC17 -9548 9385
H2BC15 -8043 9295
H3-3A -7626 7362
MBD2 -6464 8407
H2AJ -9643 3819
MAPK3 -2453 1079

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
H2AC20 -9250.0 -2501.0
H2AC6 -10474.0 9891.0
H2AJ -9643.0 3819.0
H2AZ2 -7005.0 -9940.0
H2BC11 -10259.0 9781.0
H2BC12 -10074.0 9601.0
H2BC15 -8043.0 9295.0
H2BC17 -9548.0 9385.0
H2BC21 -10432.0 9790.0
H2BC4 -9769.0 9809.0
H2BC5 -9558.0 9491.0
H2BC9 -9291.0 9901.0
H3-3A -7626.0 7362.0
H3C15 5171.5 -2477.5
MAPK3 -2453.0 1079.0
MBD2 -6464.0 8407.0
UBTF 6712.0 -10702.0



Peptide chain elongation
Peptide chain elongation
metric value
setSize 88
pMANOVA 1.41e-47
p.adjustMANOVA 1.6e-45
s.dist 0.843
s.crp_eos_adj -0.843
s.dex_eos_adj -0.014
p.crp_eos_adj 1.15e-42
p.dex_eos_adj 0.821



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL13 -7349 -6766
RPL12 -9894 -4596
RPL27A -9268 -4885
RPL22 -9606 -4134
RPL39L -8439 -4668
RPL7 -10190 -3858
RPS17 -8642 -4422
RPS12 -8238 -4234
RPL31 -9466 -3680
RPS3A -10095 -3399
RPS27A -9092 -3694
RPLP1 -7064 -4669
RPL35 -9315 -3278
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS20 -10024 -2100
RPL36 -7434 -2774
RPL5 -10093 -2038
RPS13 -10205 -1877
RPL13A -9485 -1976

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EEF1A1 -9699 -1708
EEF2 -7219 584
FAU -8964 528
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



Formation of a pool of free 40S subunits
Formation of a pool of free 40S subunits
metric value
setSize 100
pMANOVA 1.17e-52
p.adjustMANOVA 1.88e-50
s.dist 0.843
s.crp_eos_adj -0.842
s.dex_eos_adj 0.016
p.crp_eos_adj 3.11e-48
p.dex_eos_adj 0.783



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
EIF3J -8885 6066
EIF3B -8353 5747
RPL26L1 -8788 4937
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
UBA52 -9492 3637
EIF1AX -6419 5278
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF3H -9903 2488
RPL8 -9828 1921
RPS14 -8102 2275
RPL15 -9885 1682
RPS27L -8745 1793
EIF3A -6824 2200
EIF3G -8961 1578
RPL39 -9434 1424

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
FAU -8964 528
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



Eukaryotic Translation Elongation
Eukaryotic Translation Elongation
metric value
setSize 93
pMANOVA 1.9e-49
p.adjustMANOVA 2.45e-47
s.dist 0.835
s.crp_eos_adj -0.834
s.dex_eos_adj -0.0176
p.crp_eos_adj 3.7e-44
p.dex_eos_adj 0.769



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL13 -7349 -6766
RPL12 -9894 -4596
RPL27A -9268 -4885
EEF1B2 -9599 -4324
RPL22 -9606 -4134
RPL39L -8439 -4668
RPL7 -10190 -3858
RPS17 -8642 -4422
RPS12 -8238 -4234
RPL31 -9466 -3680
RPS3A -10095 -3399
RPS27A -9092 -3694
RPLP1 -7064 -4669
RPL35 -9315 -3278
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS20 -10024 -2100
RPL36 -7434 -2774
RPL5 -10093 -2038
EEF1A1P5 -8838 -2290

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EEF1A1 -9699 -1708
EEF1A1P5 -8838 -2290
EEF1A2 -106 353
EEF1B2 -9599 -4324
EEF1D -7497 -341
EEF1G -9228 -1565
EEF2 -7219 584
FAU -8964 528
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



Tandem pore domain potassium channels
Tandem pore domain potassium channels
metric value
setSize 5
pMANOVA 0.0183
p.adjustMANOVA 0.0546
s.dist 0.831
s.crp_eos_adj 0.463
s.dex_eos_adj -0.69
p.crp_eos_adj 0.0729
p.dex_eos_adj 0.0075



Top 20 genes
Gene crp_eos_adj dex_eos_adj
KCNK13 11022 -6621
KCNK10 6035 -11174
KCNK7 10562 -4232
KCNK17 1685 -8317

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
KCNK10 6035 -11174
KCNK13 11022 -6621
KCNK17 1685 -8317
KCNK6 -1403 -11332
KCNK7 10562 -4232



Viral mRNA Translation
Viral mRNA Translation
metric value
setSize 88
pMANOVA 9.47e-46
p.adjustMANOVA 9.63e-44
s.dist 0.831
s.crp_eos_adj -0.831
s.dex_eos_adj 0.000516
p.crp_eos_adj 1.49e-41
p.dex_eos_adj 0.993



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
GRSF1 -9525 5527
RPL26L1 -8788 4937
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
UBA52 -9492 3637
RPS4Y1 -7139 3934
RPL8 -9828 1921
RPS14 -8102 2275
RPL15 -9885 1682
RPS27L -8745 1793
RPL39 -9434 1424
RPL7A -9895 1279
RPL29 -10018 915
RPS11 -9342 896
RPLP0 -9306 805
RPL37 -8133 801
RPL24 -10168 630
RPL32 -9631 580

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
DNAJC3 3671 7321
FAU -8964 528
GRSF1 -9525 5527
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



L13a-mediated translational silencing of Ceruloplasmin expression
L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 110
pMANOVA 4.15e-54
p.adjustMANOVA 8.03e-52
s.dist 0.828
s.crp_eos_adj -0.826
s.dex_eos_adj 0.054
p.crp_eos_adj 6.06e-51
p.dex_eos_adj 0.328



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
RPL26L1 -8788 4937
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
EIF4H -8740 3960
UBA52 -9492 3637
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2S1 -4352 5718
EIF3H -9903 2488
RPL8 -9828 1921
RPS14 -8102 2275

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4G1 782 8831
EIF4H -8740 3960
FAU -8964 528
PABPC1 -9587 1364
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is conjugated to E1 (UBA2:SAE1)
metric value
setSize 5
pMANOVA 0.0146
p.adjustMANOVA 0.0458
s.dist 0.824
s.crp_eos_adj -0.744
s.dex_eos_adj 0.356
p.crp_eos_adj 0.00398
p.dex_eos_adj 0.168



Top 20 genes
Gene crp_eos_adj dex_eos_adj
SAE1 -10054 6672
UBA2 -7335 7043
SUMO3 -7807 3288
SUMO2 -8085 539

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
SAE1 -10054 6672
SUMO1 -5166 -1663
SUMO2 -8085 539
SUMO3 -7807 3288
UBA2 -7335 7043



GTP hydrolysis and joining of the 60S ribosomal subunit
GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 111
pMANOVA 4.92e-54
p.adjustMANOVA 8.63e-52
s.dist 0.824
s.crp_eos_adj -0.822
s.dex_eos_adj 0.0532
p.crp_eos_adj 7.35e-51
p.dex_eos_adj 0.333



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
RPL26L1 -8788 4937
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
EIF4H -8740 3960
UBA52 -9492 3637
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2S1 -4352 5718
EIF3H -9903 2488
RPL8 -9828 1921
EIF5 -8530 2194

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4G1 782 8831
EIF4H -8740 3960
EIF5 -8530 2194
EIF5B -4211 -1907
FAU -8964 528
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



Formation of xylulose-5-phosphate
Formation of xylulose-5-phosphate
metric value
setSize 5
pMANOVA 0.000422
p.adjustMANOVA 0.00215
s.dist 0.823
s.crp_eos_adj -0.602
s.dex_eos_adj -0.56
p.crp_eos_adj 0.0197
p.dex_eos_adj 0.03



Top 20 genes
Gene crp_eos_adj dex_eos_adj
XYLB -9299 -7021
CRYL1 -8770 -6765
AKR1A1 -9194 -6168
DCXR -9657 -3144

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AKR1A1 -9194 -6168
CRYL1 -8770 -6765
DCXR -9657 -3144
SORD 6232 -11425
XYLB -9299 -7021



SARS-CoV-1 modulates host translation machinery
SARS-CoV-1 modulates host translation machinery
metric value
setSize 36
pMANOVA 1.55e-18
p.adjustMANOVA 5.53e-17
s.dist 0.819
s.crp_eos_adj -0.819
s.dex_eos_adj 0.00517
p.crp_eos_adj 1.72e-17
p.dex_eos_adj 0.957



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPSA -9567 4040
RPS4X -10091 3529
HNRNPA1 -9025 3889
RPS4Y1 -7139 3934
RPS14 -8102 2275
RPS27L -8745 1793
RPS11 -9342 896
RPS27 -9689 576
FAU -8964 528
RPS15A -9863 438
RPS9 -9545 341
RPS29 -7204 240
RPS3 -9513 39

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EEF1A1 -9699 -1708
FAU -8964 528
HNRNPA1 -9025 3889
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040



Cap-dependent Translation Initiation
Cap-dependent Translation Initiation
metric value
setSize 118
pMANOVA 5.82e-57
p.adjustMANOVA 1.25e-54
s.dist 0.818
s.crp_eos_adj -0.817
s.dex_eos_adj 0.0454
p.crp_eos_adj 2.87e-53
p.dex_eos_adj 0.395



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
RPL26L1 -8788 4937
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
EIF4H -8740 3960
UBA52 -9492 3637
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2B2 -9052 2798
EIF2S1 -4352 5718
EIF3H -9903 2488
EIF2B4 -5451 3788

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2B1 -8804 -8266
EIF2B2 -9052 2798
EIF2B3 -6023 -7686
EIF2B4 -5451 3788
EIF2B5 -3130 -4487
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4EBP1 -10210 1214
EIF4G1 782 8831
EIF4H -8740 3960
EIF5 -8530 2194
EIF5B -4211 -1907
FAU -8964 528
PABPC1 -9587 1364
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



Eukaryotic Translation Initiation
Eukaryotic Translation Initiation
metric value
setSize 118
pMANOVA 5.82e-57
p.adjustMANOVA 1.25e-54
s.dist 0.818
s.crp_eos_adj -0.817
s.dex_eos_adj 0.0454
p.crp_eos_adj 2.87e-53
p.dex_eos_adj 0.395



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
RPL26L1 -8788 4937
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
EIF4H -8740 3960
UBA52 -9492 3637
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2B2 -9052 2798
EIF2S1 -4352 5718
EIF3H -9903 2488
EIF2B4 -5451 3788

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2B1 -8804 -8266
EIF2B2 -9052 2798
EIF2B3 -6023 -7686
EIF2B4 -5451 3788
EIF2B5 -3130 -4487
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4EBP1 -10210 1214
EIF4G1 782 8831
EIF4H -8740 3960
EIF5 -8530 2194
EIF5B -4211 -1907
FAU -8964 528
PABPC1 -9587 1364
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637



Formation of the ternary complex, and subsequently, the 43S complex
Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 51
pMANOVA 2.55e-24
p.adjustMANOVA 1.07e-22
s.dist 0.816
s.crp_eos_adj -0.813
s.dex_eos_adj 0.0727
p.crp_eos_adj 9.14e-24
p.dex_eos_adj 0.369



Top 20 genes
Gene crp_eos_adj dex_eos_adj
EIF3J -8885 6066
EIF3B -8353 5747
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
EIF1AX -6419 5278
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF2S1 -4352 5718
EIF3H -9903 2488
RPS14 -8102 2275
EIF2S3 -8787 1977
RPS27L -8745 1793
EIF3A -6824 2200
EIF3G -8961 1578
EIF3K -9763 887
EIF2S2 -8034 1064
RPS11 -9342 896
RPS27 -9689 576
EIF3E -9855 483

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
FAU -8964 528
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040



Interleukin-21 signaling
Interleukin-21 signaling
metric value
setSize 9
pMANOVA 0.00124
p.adjustMANOVA 0.00567
s.dist 0.814
s.crp_eos_adj 0.628
s.dex_eos_adj -0.517
p.crp_eos_adj 0.00111
p.dex_eos_adj 0.00718



Top 20 genes
Gene crp_eos_adj dex_eos_adj
IL21R 11143 -11518
IL2RG 8651 -10511
STAT4 10642 -8530
STAT5B 7816 -10176
JAK3 9574 -5125
STAT1 2463 -9595

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
IL21R 11143 -11518
IL2RG 8651 -10511
JAK1 9474 983
JAK3 9574 -5125
STAT1 2463 -9595
STAT3 7682 5827
STAT4 10642 -8530
STAT5A -942 -9235
STAT5B 7816 -10176



Mitochondrial translation initiation
Mitochondrial translation initiation
metric value
setSize 90
pMANOVA 2.71e-41
p.adjustMANOVA 2.02e-39
s.dist 0.812
s.crp_eos_adj -0.807
s.dex_eos_adj 0.0909
p.crp_eos_adj 4.02e-40
p.dex_eos_adj 0.136



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MRPL3 -10393 10140
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MRPL15 -10455 8814
MRPS17 -9266 6882
MRPS2 -8399 6472
MRPL36 -9298 5552
MRPL40 -9938 5084
MRPS30 -7283 6602
MRPS22 -10100 4669
MRPL32 -9896 4557
MRPL48 -9656 4635
MRPL24 -9309 4707
MRPS21 -10336 4159
MRPS27 -9510 4499
MRPS35 -9046 4638
MRPS16 -10322 3980
MRPS5 -9019 4506
MRPS15 -10132 3806
MRPL4 -8531 4487

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AURKAIP1 -7163 501
CHCHD1 -9554 -1063
DAP3 -10029 -741
ERAL1 -7966 -1506
GADD45GIP1 -9420 3582
MRPL1 -6879 3433
MRPL10 -7218 1667
MRPL11 -9723 1301
MRPL12 -9704 -1577
MRPL13 -7768 -3257
MRPL14 -8516 -1654
MRPL15 -10455 8814
MRPL16 -9444 -561
MRPL17 -9914 767
MRPL18 -8751 -4188
MRPL19 -6742 1950
MRPL2 -5521 -10048
MRPL20 -9597 2374
MRPL21 -8108 4026
MRPL22 -7417 -568
MRPL23 -8375 -504
MRPL24 -9309 4707
MRPL27 -8986 -4004
MRPL28 -6205 -854
MRPL3 -10393 10140
MRPL30 -6129 -7501
MRPL32 -9896 4557
MRPL33 -7353 -5238
MRPL34 -9811 1839
MRPL35 -5551 -4517
MRPL36 -9298 5552
MRPL37 -10431 266
MRPL38 -7020 -94
MRPL39 -5937 -1076
MRPL4 -8531 4487
MRPL40 -9938 5084
MRPL41 -5085 -4089
MRPL42 -3938 -148
MRPL43 -7617 -4753
MRPL44 -9483 2066
MRPL45 -9714 -4705
MRPL46 -9616 -2776
MRPL47 -8492 2912
MRPL48 -9656 4635
MRPL49 -8602 2879
MRPL50 -1529 716
MRPL51 -10127 494
MRPL52 -9359 -1652
MRPL53 -9119 328
MRPL54 -9274 -6380
MRPL55 -8074 2047
MRPL57 -9893 -1392
MRPL58 -9020 306
MRPL9 -8851 14
MRPS10 -6116 597
MRPS11 -9135 -1479
MRPS14 -8019 -1134
MRPS15 -10132 3806
MRPS16 -10322 3980
MRPS17 -9266 6882
MRPS18A -8449 1117
MRPS18B -9490 1569
MRPS18C -9472 -5773
MRPS2 -8399 6472
MRPS21 -10336 4159
MRPS22 -10100 4669
MRPS23 -8641 -2834
MRPS24 -8475 -2182
MRPS25 -6379 -8304
MRPS26 -8775 1908
MRPS27 -9510 4499
MRPS28 -10276 -653
MRPS30 -7283 6602
MRPS31 -5589 -1630
MRPS33 -7000 -8376
MRPS34 -7830 -372
MRPS35 -9046 4638
MRPS36 -6781 356
MRPS5 -9019 4506
MRPS6 3568 -11687
MRPS7 -10039 1776
MRPS9 -7311 -10532
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
MTFMT -8156 146
MTIF2 -9774 366
MTIF3 -8993 -2549
OXA1L -8897 -1994
PTCD3 -8572 3087
RPS12 -8238 -4234



G2/M DNA replication checkpoint
G2/M DNA replication checkpoint
metric value
setSize 5
pMANOVA 0.0254
p.adjustMANOVA 0.0721
s.dist 0.812
s.crp_eos_adj -0.551
s.dex_eos_adj 0.596
p.crp_eos_adj 0.0328
p.dex_eos_adj 0.021



Top 20 genes
Gene crp_eos_adj dex_eos_adj
CCNB2 -9011 5562
PKMYT1 -6895 5895
CCNB1 -7718 4998
CDK1 -6731 2713

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
CCNB1 -7718 4998
CCNB2 -9011 5562
CDK1 -6731 2713
PKMYT1 -6895 5895
WEE1 2476 9887



rRNA processing in the mitochondrion
rRNA processing in the mitochondrion
metric value
setSize 24
pMANOVA 1.03e-08
p.adjustMANOVA 1.17e-07
s.dist 0.811
s.crp_eos_adj -0.68
s.dex_eos_adj 0.442
p.crp_eos_adj 7.81e-09
p.dex_eos_adj 0.000179



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MT-ND2 -10254 9404
MT-ND1 -10175 9474
MT-ND3 -10178 8131
MT-CO2 -9586 8379
MT-ATP6 -8913 8600
MT-CYB -7733 9007
MT-CO3 -9084 7529
MT-ND4 -7514 8813
MT-ND4L -8461 7596
MT-ND5 -6746 9069
MT-CO1 -7200 7481
PRORP -6414 8022
ELAC2 -6478 2660
NSUN4 -3181 4367
MT-ATP8 -5196 2309
MRM3 -8487 884
TRMT10C -7180 565

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ELAC2 -6478 2660
HSD17B10 -7811 -2666
MRM1 -6592 -4367
MRM2 -10098 -4732
MRM3 -8487 884
MT-ATP6 -8913 8600
MT-ATP8 -5196 2309
MT-CO1 -7200 7481
MT-CO2 -9586 8379
MT-CO3 -9084 7529
MT-CYB -7733 9007
MT-ND1 -10175 9474
MT-ND2 -10254 9404
MT-ND3 -10178 8131
MT-ND4 -7514 8813
MT-ND4L -8461 7596
MT-ND5 -6746 9069
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
MTERF4 8548 -11451
NSUN4 -3181 4367
PRORP -6414 8022
TFB1M 2012 -9238
TRMT10C -7180 565



SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
metric value
setSize 111
pMANOVA 1.2e-50
p.adjustMANOVA 1.66e-48
s.dist 0.81
s.crp_eos_adj -0.805
s.dex_eos_adj 0.0881
p.crp_eos_adj 6.9e-49
p.dex_eos_adj 0.109



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPN1 -9288 8352
SRP72 -9096 7668
SSR3 -9814 6929
SEC61A1 -8132 8087
RPL22L1 -10141 5971
SEC11C -9091 6520
SEC61G -8479 6895
SPCS1 -9985 5837
RPN2 -9208 6239
SEC61B -8032 6573
SPCS2 -7055 6779
SSR2 -9869 4430
SRPRB -9772 4440
RPL26L1 -8788 4937
TRAM1 -7257 5587
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
UBA52 -9492 3637
SSR4 -9402 3498

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
DDOST -9050 3588
FAU -8964 528
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPN1 -9288 8352
RPN2 -9208 6239
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
SEC11A -10173 -5885
SEC11C -9091 6520
SEC61A1 -8132 8087
SEC61A2 4645 1034
SEC61B -8032 6573
SEC61G -8479 6895
SPCS1 -9985 5837
SPCS2 -7055 6779
SPCS3 -3043 6290
SRP14 -9354 -493
SRP19 -4244 4146
SRP54 -996 2915
SRP68 -7245 -273
SRP72 -9096 7668
SRP9 -8845 3067
SRPRA 2035 659
SRPRB -9772 4440
SSR1 -1071 -570
SSR2 -9869 4430
SSR3 -9814 6929
SSR4 -9402 3498
TRAM1 -7257 5587
UBA52 -9492 3637



Eukaryotic Translation Termination
Eukaryotic Translation Termination
metric value
setSize 92
pMANOVA 5.57e-46
p.adjustMANOVA 5.98e-44
s.dist 0.81
s.crp_eos_adj -0.81
s.dex_eos_adj -0.0138
p.crp_eos_adj 2.94e-41
p.dex_eos_adj 0.819



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL13 -7349 -6766
RPL12 -9894 -4596
RPL27A -9268 -4885
RPL22 -9606 -4134
RPL39L -8439 -4668
RPL7 -10190 -3858
RPS17 -8642 -4422
RPS12 -8238 -4234
RPL31 -9466 -3680
RPS3A -10095 -3399
RPS27A -9092 -3694
RPLP1 -7064 -4669
RPL35 -9315 -3278
TRMT112 -9205 -3259
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS20 -10024 -2100
RPL36 -7434 -2774
RPL5 -10093 -2038
RPS13 -10205 -1877

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
APEH -8185 932
ETF1 -2337 4540
FAU -8964 528
GSPT1 -2717 8704
GSPT2 -1662 -6497
N6AMT1 5290 -8948
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
TRMT112 -9205 -3259
UBA52 -9492 3637



Post-transcriptional silencing by small RNAs
Post-transcriptional silencing by small RNAs
metric value
setSize 7
pMANOVA 0.00389
p.adjustMANOVA 0.0156
s.dist 0.81
s.crp_eos_adj 0.712
s.dex_eos_adj -0.386
p.crp_eos_adj 0.00111
p.dex_eos_adj 0.0772



Top 20 genes
Gene crp_eos_adj dex_eos_adj
AGO1 10040 -11639
TNRC6C 11323 -9642
TNRC6A 6070 -7296
TNRC6B 10293 -4086
AGO4 8889 -2865
AGO3 4583 -4205

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AGO1 10040 -11639
AGO2 7012 4852
AGO3 4583 -4205
AGO4 8889 -2865
TNRC6A 6070 -7296
TNRC6B 10293 -4086
TNRC6C 11323 -9642



Packaging Of Telomere Ends
Packaging Of Telomere Ends
metric value
setSize 18
pMANOVA 8.15e-07
p.adjustMANOVA 6.79e-06
s.dist 0.81
s.crp_eos_adj -0.698
s.dex_eos_adj 0.41
p.crp_eos_adj 2.9e-07
p.dex_eos_adj 0.00261



Top 20 genes
Gene crp_eos_adj dex_eos_adj
H2AC6 -10474 9891
H2BC21 -10432 9790
H2BC11 -10259 9781
H2BC12 -10074 9601
H2BC4 -9769 9809
H2BC9 -9291 9901
H2BC5 -9558 9491
H2BC17 -9548 9385
H2BC15 -8043 9295
H2AJ -9643 3819
TINF2 -4188 2655

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ACD -4588 -327
H2AC20 -9250 -2501
H2AC6 -10474 9891
H2AJ -9643 3819
H2AZ2 -7005 -9940
H2BC11 -10259 9781
H2BC12 -10074 9601
H2BC15 -8043 9295
H2BC17 -9548 9385
H2BC21 -10432 9790
H2BC4 -9769 9809
H2BC5 -9558 9491
H2BC9 -9291 9901
POT1 -871 -6259
TERF1 -4045 -1651
TERF2 -952 -3416
TERF2IP -1376 -1612
TINF2 -4188 2655



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
metric value
setSize 59
pMANOVA 4e-26
p.adjustMANOVA 1.84e-24
s.dist 0.806
s.crp_eos_adj -0.796
s.dex_eos_adj 0.122
p.crp_eos_adj 3.26e-26
p.dex_eos_adj 0.104



Top 20 genes
Gene crp_eos_adj dex_eos_adj
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
EIF4H -8740 3960
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2S1 -4352 5718
EIF3H -9903 2488
RPS14 -8102 2275
EIF2S3 -8787 1977
RPS27L -8745 1793
EIF3A -6824 2200
EIF3G -8961 1578
PABPC1 -9587 1364

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4EBP1 -10210 1214
EIF4G1 782 8831
EIF4H -8740 3960
FAU -8964 528
PABPC1 -9587 1364
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040



Selenocysteine synthesis
Selenocysteine synthesis
metric value
setSize 92
pMANOVA 1.16e-45
p.adjustMANOVA 1.12e-43
s.dist 0.805
s.crp_eos_adj -0.805
s.dex_eos_adj -0.0205
p.crp_eos_adj 9.69e-41
p.dex_eos_adj 0.734



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL13 -7349 -6766
RPL12 -9894 -4596
RPL27A -9268 -4885
RPL22 -9606 -4134
RPL39L -8439 -4668
RPL7 -10190 -3858
RPS17 -8642 -4422
RPS12 -8238 -4234
RPL31 -9466 -3680
RPS3A -10095 -3399
RPS27A -9092 -3694
RPLP1 -7064 -4669
RPL35 -9315 -3278
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS20 -10024 -2100
RPL36 -7434 -2774
RPL5 -10093 -2038
RPS13 -10205 -1877
RPL13A -9485 -1976

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EEFSEC -8494 -133
FAU -8964 528
PSTK -117 -1779
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
SARS1 -6943 -2110
SECISBP2 -1781 -3359
SEPHS2 1631 -844
SEPSECS 2236 -3052
UBA52 -9492 3637



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 94
pMANOVA 8.76e-45
p.adjustMANOVA 8.06e-43
s.dist 0.802
s.crp_eos_adj -0.802
s.dex_eos_adj 0.0202
p.crp_eos_adj 2.37e-41
p.dex_eos_adj 0.735



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RPL22L1 -10141 5971
RPL26L1 -8788 4937
RPSA -9567 4040
RPS4X -10091 3529
RPL36AL -6618 5375
UBA52 -9492 3637
RPS4Y1 -7139 3934
GSPT1 -2717 8704
RPL8 -9828 1921
RPS14 -8102 2275
RPL15 -9885 1682
NCBP2 -7939 2045
RPS27L -8745 1793
UPF1 -2229 6638
RPL39 -9434 1424
PABPC1 -9587 1364
RPL7A -9895 1279
ETF1 -2337 4540
RPL29 -10018 915
RPS11 -9342 896

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF4G1 782 8831
ETF1 -2337 4540
FAU -8964 528
GSPT1 -2717 8704
GSPT2 -1662 -6497
NCBP1 -1909 3054
NCBP2 -7939 2045
PABPC1 -9587 1364
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
UBA52 -9492 3637
UPF1 -2229 6638



Translation initiation complex formation
Translation initiation complex formation
metric value
setSize 58
pMANOVA 1.67e-25
p.adjustMANOVA 7.49e-24
s.dist 0.802
s.crp_eos_adj -0.793
s.dex_eos_adj 0.121
p.crp_eos_adj 1.32e-25
p.dex_eos_adj 0.11



Top 20 genes
Gene crp_eos_adj dex_eos_adj
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
EIF4H -8740 3960
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2S1 -4352 5718
EIF3H -9903 2488
RPS14 -8102 2275
EIF2S3 -8787 1977
RPS27L -8745 1793
EIF3A -6824 2200
EIF3G -8961 1578
PABPC1 -9587 1364

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4G1 782 8831
EIF4H -8740 3960
FAU -8964 528
PABPC1 -9587 1364
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040



Ribosomal scanning and start codon recognition
Ribosomal scanning and start codon recognition
metric value
setSize 58
pMANOVA 2.22e-25
p.adjustMANOVA 9.75e-24
s.dist 0.801
s.crp_eos_adj -0.791
s.dex_eos_adj 0.123
p.crp_eos_adj 1.66e-25
p.dex_eos_adj 0.106



Top 20 genes
Gene crp_eos_adj dex_eos_adj
EIF4A1 -9230 6226
EIF3J -8885 6066
EIF3B -8353 5747
EIF3M -10391 3786
RPSA -9567 4040
RPS4X -10091 3529
EIF4H -8740 3960
EIF1AX -6419 5278
EIF4E -5066 6356
RPS4Y1 -7139 3934
EIF3I -9538 2930
EIF4B -9348 2862
EIF2S1 -4352 5718
EIF3H -9903 2488
EIF5 -8530 2194
RPS14 -8102 2275
EIF2S3 -8787 1977
RPS27L -8745 1793
EIF3A -6824 2200
EIF3G -8961 1578

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
EIF1AX -6419 5278
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
EIF3A -6824 2200
EIF3B -8353 5747
EIF3C -7213 -6229
EIF3D -9076 409
EIF3E -9855 483
EIF3F -6729 -3738
EIF3G -8961 1578
EIF3H -9903 2488
EIF3I -9538 2930
EIF3J -8885 6066
EIF3K -9763 887
EIF3L -9325 -958
EIF3M -10391 3786
EIF4A1 -9230 6226
EIF4A2 -5245 1728
EIF4B -9348 2862
EIF4E -5066 6356
EIF4G1 782 8831
EIF4H -8740 3960
EIF5 -8530 2194
FAU -8964 528
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040



Mitochondrial translation elongation
Mitochondrial translation elongation
metric value
setSize 90
pMANOVA 5.95e-40
p.adjustMANOVA 3.59e-38
s.dist 0.799
s.crp_eos_adj -0.794
s.dex_eos_adj 0.0899
p.crp_eos_adj 7.27e-39
p.dex_eos_adj 0.14



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MRPL3 -10393 10140
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MRPL15 -10455 8814
MRPS17 -9266 6882
MRPS2 -8399 6472
MRPL36 -9298 5552
MRPL40 -9938 5084
MRPS30 -7283 6602
MRPS22 -10100 4669
MRPL32 -9896 4557
MRPL48 -9656 4635
MRPL24 -9309 4707
MRPS21 -10336 4159
MRPS27 -9510 4499
MRPS35 -9046 4638
MRPS16 -10322 3980
MRPS5 -9019 4506
MRPS15 -10132 3806
MRPL4 -8531 4487

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AURKAIP1 -7163 501
CHCHD1 -9554 -1063
DAP3 -10029 -741
ERAL1 -7966 -1506
GADD45GIP1 -9420 3582
GFM1 4523 2751
MRPL1 -6879 3433
MRPL10 -7218 1667
MRPL11 -9723 1301
MRPL12 -9704 -1577
MRPL13 -7768 -3257
MRPL14 -8516 -1654
MRPL15 -10455 8814
MRPL16 -9444 -561
MRPL17 -9914 767
MRPL18 -8751 -4188
MRPL19 -6742 1950
MRPL2 -5521 -10048
MRPL20 -9597 2374
MRPL21 -8108 4026
MRPL22 -7417 -568
MRPL23 -8375 -504
MRPL24 -9309 4707
MRPL27 -8986 -4004
MRPL28 -6205 -854
MRPL3 -10393 10140
MRPL30 -6129 -7501
MRPL32 -9896 4557
MRPL33 -7353 -5238
MRPL34 -9811 1839
MRPL35 -5551 -4517
MRPL36 -9298 5552
MRPL37 -10431 266
MRPL38 -7020 -94
MRPL39 -5937 -1076
MRPL4 -8531 4487
MRPL40 -9938 5084
MRPL41 -5085 -4089
MRPL42 -3938 -148
MRPL43 -7617 -4753
MRPL44 -9483 2066
MRPL45 -9714 -4705
MRPL46 -9616 -2776
MRPL47 -8492 2912
MRPL48 -9656 4635
MRPL49 -8602 2879
MRPL50 -1529 716
MRPL51 -10127 494
MRPL52 -9359 -1652
MRPL53 -9119 328
MRPL54 -9274 -6380
MRPL55 -8074 2047
MRPL57 -9893 -1392
MRPL58 -9020 306
MRPL9 -8851 14
MRPS10 -6116 597
MRPS11 -9135 -1479
MRPS14 -8019 -1134
MRPS15 -10132 3806
MRPS16 -10322 3980
MRPS17 -9266 6882
MRPS18A -8449 1117
MRPS18B -9490 1569
MRPS18C -9472 -5773
MRPS2 -8399 6472
MRPS21 -10336 4159
MRPS22 -10100 4669
MRPS23 -8641 -2834
MRPS24 -8475 -2182
MRPS25 -6379 -8304
MRPS26 -8775 1908
MRPS27 -9510 4499
MRPS28 -10276 -653
MRPS30 -7283 6602
MRPS31 -5589 -1630
MRPS33 -7000 -8376
MRPS34 -7830 -372
MRPS35 -9046 4638
MRPS36 -6781 356
MRPS5 -9019 4506
MRPS6 3568 -11687
MRPS7 -10039 1776
MRPS9 -7311 -10532
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
OXA1L -8897 -1994
PTCD3 -8572 3087
RPS12 -8238 -4234
TSFM -9743 -6172
TUFM -8624 416



G2 Phase
G2 Phase
metric value
setSize 5
pMANOVA 0.0289
p.adjustMANOVA 0.0798
s.dist 0.794
s.crp_eos_adj -0.51
s.dex_eos_adj 0.61
p.crp_eos_adj 0.0485
p.dex_eos_adj 0.0182



Top 20 genes
Gene crp_eos_adj dex_eos_adj
CCNA1 -6636 10050
E2F1 -10206 6459
CCNA2 -5238 3991
E2F3 -1579 9952

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
CCNA1 -6636 10050
CCNA2 -5238 3991
CDK2 -1921 -645
E2F1 -10206 6459
E2F3 -1579 9952



Mitochondrial translation termination
Mitochondrial translation termination
metric value
setSize 90
pMANOVA 6.55e-39
p.adjustMANOVA 3.83e-37
s.dist 0.789
s.crp_eos_adj -0.783
s.dex_eos_adj 0.09
p.crp_eos_adj 6.58e-38
p.dex_eos_adj 0.14



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MRPL3 -10393 10140
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MRPL15 -10455 8814
MRPS17 -9266 6882
MRPS2 -8399 6472
MRPL36 -9298 5552
MRPL40 -9938 5084
MRPS30 -7283 6602
MRPS22 -10100 4669
MRPL32 -9896 4557
MRPL48 -9656 4635
MRPL24 -9309 4707
MRPS21 -10336 4159
MRPS27 -9510 4499
MRPS35 -9046 4638
MRPS16 -10322 3980
MRPS5 -9019 4506
MRPS15 -10132 3806
MRPL4 -8531 4487

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AURKAIP1 -7163 501
CHCHD1 -9554 -1063
DAP3 -10029 -741
ERAL1 -7966 -1506
GADD45GIP1 -9420 3582
GFM2 -152 -2105
MRPL1 -6879 3433
MRPL10 -7218 1667
MRPL11 -9723 1301
MRPL12 -9704 -1577
MRPL13 -7768 -3257
MRPL14 -8516 -1654
MRPL15 -10455 8814
MRPL16 -9444 -561
MRPL17 -9914 767
MRPL18 -8751 -4188
MRPL19 -6742 1950
MRPL2 -5521 -10048
MRPL20 -9597 2374
MRPL21 -8108 4026
MRPL22 -7417 -568
MRPL23 -8375 -504
MRPL24 -9309 4707
MRPL27 -8986 -4004
MRPL28 -6205 -854
MRPL3 -10393 10140
MRPL30 -6129 -7501
MRPL32 -9896 4557
MRPL33 -7353 -5238
MRPL34 -9811 1839
MRPL35 -5551 -4517
MRPL36 -9298 5552
MRPL37 -10431 266
MRPL38 -7020 -94
MRPL39 -5937 -1076
MRPL4 -8531 4487
MRPL40 -9938 5084
MRPL41 -5085 -4089
MRPL42 -3938 -148
MRPL43 -7617 -4753
MRPL44 -9483 2066
MRPL45 -9714 -4705
MRPL46 -9616 -2776
MRPL47 -8492 2912
MRPL48 -9656 4635
MRPL49 -8602 2879
MRPL50 -1529 716
MRPL51 -10127 494
MRPL52 -9359 -1652
MRPL53 -9119 328
MRPL54 -9274 -6380
MRPL55 -8074 2047
MRPL57 -9893 -1392
MRPL58 -9020 306
MRPL9 -8851 14
MRPS10 -6116 597
MRPS11 -9135 -1479
MRPS14 -8019 -1134
MRPS15 -10132 3806
MRPS16 -10322 3980
MRPS17 -9266 6882
MRPS18A -8449 1117
MRPS18B -9490 1569
MRPS18C -9472 -5773
MRPS2 -8399 6472
MRPS21 -10336 4159
MRPS22 -10100 4669
MRPS23 -8641 -2834
MRPS24 -8475 -2182
MRPS25 -6379 -8304
MRPS26 -8775 1908
MRPS27 -9510 4499
MRPS28 -10276 -653
MRPS30 -7283 6602
MRPS31 -5589 -1630
MRPS33 -7000 -8376
MRPS34 -7830 -372
MRPS35 -9046 4638
MRPS36 -6781 356
MRPS5 -9019 4506
MRPS6 3568 -11687
MRPS7 -10039 1776
MRPS9 -7311 -10532
MRRF -8705 -4306
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
MTRF1L 5121 3514
OXA1L -8897 -1994
PTCD3 -8572 3087
RPS12 -8238 -4234



Phosphate bond hydrolysis by NUDT proteins
Phosphate bond hydrolysis by NUDT proteins
metric value
setSize 7
pMANOVA 0.00271
p.adjustMANOVA 0.0113
s.dist 0.782
s.crp_eos_adj -0.749
s.dex_eos_adj 0.223
p.crp_eos_adj 0.000594
p.dex_eos_adj 0.306



Top 20 genes
Gene crp_eos_adj dex_eos_adj
NUDT16 -10283 10255
ADPRM -9913 8395
NUDT15 -8716 5734
NUDT5 -7240 4383

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ADPRM -9913 8395
NUDT1 -9395 -6389
NUDT15 -8716 5734
NUDT16 -10283 10255
NUDT18 -6890 -1365
NUDT5 -7240 4383
NUDT9 -1841 -9009



Mitochondrial translation
Mitochondrial translation
metric value
setSize 96
pMANOVA 7.6e-41
p.adjustMANOVA 5.43e-39
s.dist 0.781
s.crp_eos_adj -0.776
s.dex_eos_adj 0.0839
p.crp_eos_adj 1.31e-39
p.dex_eos_adj 0.156



Top 20 genes
Gene crp_eos_adj dex_eos_adj
MRPL3 -10393 10140
MT-RNR2 -10511 9583
MT-RNR1 -10512 9249
MRPL15 -10455 8814
MRPS17 -9266 6882
MRPS2 -8399 6472
MRPL36 -9298 5552
MRPL40 -9938 5084
MRPS30 -7283 6602
MRPS22 -10100 4669
MRPL32 -9896 4557
MRPL48 -9656 4635
MRPL24 -9309 4707
MRPS21 -10336 4159
MRPS27 -9510 4499
MRPS35 -9046 4638
MRPS16 -10322 3980
MRPS5 -9019 4506
MRPS15 -10132 3806
MRPL4 -8531 4487

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AURKAIP1 -7163 501
CHCHD1 -9554 -1063
DAP3 -10029 -741
ERAL1 -7966 -1506
GADD45GIP1 -9420 3582
GFM1 4523 2751
GFM2 -152 -2105
MRPL1 -6879 3433
MRPL10 -7218 1667
MRPL11 -9723 1301
MRPL12 -9704 -1577
MRPL13 -7768 -3257
MRPL14 -8516 -1654
MRPL15 -10455 8814
MRPL16 -9444 -561
MRPL17 -9914 767
MRPL18 -8751 -4188
MRPL19 -6742 1950
MRPL2 -5521 -10048
MRPL20 -9597 2374
MRPL21 -8108 4026
MRPL22 -7417 -568
MRPL23 -8375 -504
MRPL24 -9309 4707
MRPL27 -8986 -4004
MRPL28 -6205 -854
MRPL3 -10393 10140
MRPL30 -6129 -7501
MRPL32 -9896 4557
MRPL33 -7353 -5238
MRPL34 -9811 1839
MRPL35 -5551 -4517
MRPL36 -9298 5552
MRPL37 -10431 266
MRPL38 -7020 -94
MRPL39 -5937 -1076
MRPL4 -8531 4487
MRPL40 -9938 5084
MRPL41 -5085 -4089
MRPL42 -3938 -148
MRPL43 -7617 -4753
MRPL44 -9483 2066
MRPL45 -9714 -4705
MRPL46 -9616 -2776
MRPL47 -8492 2912
MRPL48 -9656 4635
MRPL49 -8602 2879
MRPL50 -1529 716
MRPL51 -10127 494
MRPL52 -9359 -1652
MRPL53 -9119 328
MRPL54 -9274 -6380
MRPL55 -8074 2047
MRPL57 -9893 -1392
MRPL58 -9020 306
MRPL9 -8851 14
MRPS10 -6116 597
MRPS11 -9135 -1479
MRPS14 -8019 -1134
MRPS15 -10132 3806
MRPS16 -10322 3980
MRPS17 -9266 6882
MRPS18A -8449 1117
MRPS18B -9490 1569
MRPS18C -9472 -5773
MRPS2 -8399 6472
MRPS21 -10336 4159
MRPS22 -10100 4669
MRPS23 -8641 -2834
MRPS24 -8475 -2182
MRPS25 -6379 -8304
MRPS26 -8775 1908
MRPS27 -9510 4499
MRPS28 -10276 -653
MRPS30 -7283 6602
MRPS31 -5589 -1630
MRPS33 -7000 -8376
MRPS34 -7830 -372
MRPS35 -9046 4638
MRPS36 -6781 356
MRPS5 -9019 4506
MRPS6 3568 -11687
MRPS7 -10039 1776
MRPS9 -7311 -10532
MRRF -8705 -4306
MT-RNR1 -10512 9249
MT-RNR2 -10511 9583
MTFMT -8156 146
MTIF2 -9774 366
MTIF3 -8993 -2549
MTRF1L 5121 3514
OXA1L -8897 -1994
PTCD3 -8572 3087
RPS12 -8238 -4234
TSFM -9743 -6172
TUFM -8624 416



Regulation of CDH11 mRNA translation by microRNAs
Regulation of CDH11 mRNA translation by microRNAs
metric value
setSize 8
pMANOVA 0.00391
p.adjustMANOVA 0.0156
s.dist 0.779
s.crp_eos_adj 0.63
s.dex_eos_adj -0.458
p.crp_eos_adj 0.00203
p.dex_eos_adj 0.0249



Top 20 genes
Gene crp_eos_adj dex_eos_adj
AGO1 10040 -11639
TNRC6C 11323 -9642
TNRC6A 6070 -7296
TNRC6B 10293 -4086
AGO4 8889 -2865
AGO3 4583 -4205
MOV10 1105 -11341

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AGO1 10040 -11639
AGO2 7012 4852
AGO3 4583 -4205
AGO4 8889 -2865
MOV10 1105 -11341
TNRC6A 6070 -7296
TNRC6B 10293 -4086
TNRC6C 11323 -9642



Regulation of NPAS4 mRNA translation
Regulation of NPAS4 mRNA translation
metric value
setSize 8
pMANOVA 0.00391
p.adjustMANOVA 0.0156
s.dist 0.779
s.crp_eos_adj 0.63
s.dex_eos_adj -0.458
p.crp_eos_adj 0.00203
p.dex_eos_adj 0.0249



Top 20 genes
Gene crp_eos_adj dex_eos_adj
AGO1 10040 -11639
TNRC6C 11323 -9642
TNRC6A 6070 -7296
TNRC6B 10293 -4086
AGO4 8889 -2865
AGO3 4583 -4205
MOV10 1105 -11341

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
AGO1 10040 -11639
AGO2 7012 4852
AGO3 4583 -4205
AGO4 8889 -2865
MOV10 1105 -11341
TNRC6A 6070 -7296
TNRC6B 10293 -4086
TNRC6C 11323 -9642



Replacement of protamines by nucleosomes in the male pronucleus
Replacement of protamines by nucleosomes in the male pronucleus
metric value
setSize 13
pMANOVA 0.000152
p.adjustMANOVA 0.000863
s.dist 0.778
s.crp_eos_adj -0.518
s.dex_eos_adj 0.58
p.crp_eos_adj 0.00121
p.dex_eos_adj 0.000291



Top 20 genes
Gene crp_eos_adj dex_eos_adj
H2BC21 -10432 9790
H2BC11 -10259 9781
H2BC12 -10074 9601
H2BC4 -9769 9809
H2BC9 -9291 9901
H2BC5 -9558 9491
H2BC17 -9548 9385
H2BC15 -8043 9295
H3-3A -7626 7362
METTL23 -6473 325

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
H2BC11 -10259 9781
H2BC12 -10074 9601
H2BC15 -8043 9295
H2BC17 -9548 9385
H2BC21 -10432 9790
H2BC4 -9769 9809
H2BC5 -9558 9491
H2BC9 -9291 9901
H3-3A -7626 7362
HIRA 4817 -8418
METTL23 -6473 325
NPM2 7625 -272
SRPK1 10893 -2771



Complex III assembly
Complex III assembly
metric value
setSize 23
pMANOVA 4.08e-10
p.adjustMANOVA 5.84e-09
s.dist 0.765
s.crp_eos_adj -0.762
s.dex_eos_adj 0.0633
p.crp_eos_adj 2.46e-10
p.dex_eos_adj 0.599



Top 20 genes
Gene crp_eos_adj dex_eos_adj
FXN -10242 9335
MT-CYB -7733 9007
UQCRC1 -8808 7511
UQCRH -10423 4139
LETM1 -4666 8791
CYC1 -8947 4535
UQCRFS1 -8741 3672
UQCR10 -8057 3300
TTC19 -6616 1945
UQCR11 -9447 1177
HSPA9 -5918 1105

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
BCS1L -6310 -1354
CYC1 -8947 4535
FXN -10242 9335
HSCB -10019 -9269
HSPA9 -5918 1105
ISCU -8155 -3742
LETM1 -4666 8791
LYRM4 -9848 -2862
LYRM7 -2495 -7819
MT-CYB -7733 9007
NFS1 -2127 -6879
TTC19 -6616 1945
UQCC1 -7795 -5936
UQCC2 -7905 -8737
UQCC3 -7499 -2002
UQCR10 -8057 3300
UQCR11 -9447 1177
UQCRB -9948 -1912
UQCRC1 -8808 7511
UQCRC2 -10164 -2131
UQCRFS1 -8741 3672
UQCRH -10423 4139
UQCRQ -9528 -2952



Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK4 (GCN2) to amino acid deficiency
metric value
setSize 100
pMANOVA 2.47e-43
p.adjustMANOVA 2.07e-41
s.dist 0.764
s.crp_eos_adj -0.764
s.dex_eos_adj 0.0165
p.crp_eos_adj 5.86e-40
p.dex_eos_adj 0.776



Top 20 genes
Gene crp_eos_adj dex_eos_adj
ATF4 -10009 8024
RPL22L1 -10141 5971
DDIT3 -7886 5505
RPL26L1 -8788 4937
RPSA -9567 4040
EIF2AK4 -9398 3792
RPS4X -10091 3529
RPL36AL -6618 5375
UBA52 -9492 3637
RPS4Y1 -7139 3934
EIF2S1 -4352 5718
RPL8 -9828 1921
RPS14 -8102 2275
EIF2S3 -8787 1977
RPL15 -9885 1682
RPS27L -8745 1793
RPL39 -9434 1424
IMPACT -6560 1957
RPL7A -9895 1279
RPL29 -10018 915

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ASNS 8833 -6780
ATF2 -299 4933
ATF3 8370 -10864
ATF4 -10009 8024
CEBPB 7592 3735
CEBPG -7796 215
DDIT3 -7886 5505
EIF2AK4 -9398 3792
EIF2S1 -4352 5718
EIF2S2 -8034 1064
EIF2S3 -8787 1977
FAU -8964 528
GCN1 5857 3711
IMPACT -6560 1957
RPL10 -9522 -1770
RPL10A -9943 -711
RPL11 -9621 -613
RPL12 -9894 -4596
RPL13 -7349 -6766
RPL13A -9485 -1976
RPL14 -9980 -1179
RPL15 -9885 1682
RPL17 -9569 -1849
RPL18 -9600 -1137
RPL18A -9380 -419
RPL19 -9594 -952
RPL21 -9992 -1874
RPL22 -9606 -4134
RPL22L1 -10141 5971
RPL23 -9781 -1361
RPL23A -9123 -580
RPL24 -10168 630
RPL26 -9747 -394
RPL26L1 -8788 4937
RPL27 -9879 74
RPL27A -9268 -4885
RPL28 -7372 417
RPL29 -10018 915
RPL3 -8848 -1411
RPL30 -9555 407
RPL31 -9466 -3680
RPL32 -9631 580
RPL34 -9793 -1781
RPL35 -9315 -3278
RPL35A -10181 -560
RPL36 -7434 -2774
RPL36A -10048 -1758
RPL36AL -6618 5375
RPL37 -8133 801
RPL37A -9537 -1220
RPL38 -8565 -672
RPL39 -9434 1424
RPL39L -8439 -4668
RPL3L 555 -5549
RPL4 -10112 -489
RPL41 -9414 161
RPL5 -10093 -2038
RPL6 -10000 -703
RPL7 -10190 -3858
RPL7A -9895 1279
RPL8 -9828 1921
RPL9 -211 -4576
RPLP0 -9306 805
RPLP1 -7064 -4669
RPLP2 -7225 -2935
RPS10 -9273 -2281
RPS11 -9342 896
RPS12 -8238 -4234
RPS13 -10205 -1877
RPS14 -8102 2275
RPS15 -8795 -1813
RPS15A -9863 438
RPS16 -6448 -295
RPS17 -8642 -4422
RPS18 -8328 -1568
RPS19 -9141 -900
RPS2 -7849 -2330
RPS20 -10024 -2100
RPS21 -6829 -2243
RPS23 -9736 -1609
RPS24 -9901 -1711
RPS25 -10002 -1821
RPS26 7855 -5464
RPS27 -9689 576
RPS27A -9092 -3694
RPS27L -8745 1793
RPS28 -6698 -253
RPS29 -7204 240
RPS3 -9513 39
RPS3A -10095 -3399
RPS4X -10091 3529
RPS4Y1 -7139 3934
RPS5 -8386 -414
RPS6 -9824 -1788
RPS7 -10199 -405
RPS8 -9927 -856
RPS9 -9545 341
RPSA -9567 4040
TRIB3 -2985 -1492
UBA52 -9492 3637



RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in BCR signaling
metric value
setSize 6
pMANOVA 0.000497
p.adjustMANOVA 0.00248
s.dist 0.763
s.crp_eos_adj 0.338
s.dex_eos_adj 0.685
p.crp_eos_adj 0.152
p.dex_eos_adj 0.00368



Top 20 genes
Gene crp_eos_adj dex_eos_adj
RUNX1 11175 5720
ELF2 8488 6435
PAX5 6251 5756
ELF1 869 9009
CBFB 167 5289

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
BLK -1726 8508
CBFB 167 5289
ELF1 869 9009
ELF2 8488 6435
PAX5 6251 5756
RUNX1 11175 5720



Arachidonate production from DAG
Arachidonate production from DAG
metric value
setSize 5
pMANOVA 0.0145
p.adjustMANOVA 0.0455
s.dist 0.754
s.crp_eos_adj -0.741
s.dex_eos_adj 0.141
p.crp_eos_adj 0.0041
p.dex_eos_adj 0.586



Top 20 genes
Gene crp_eos_adj dex_eos_adj
ABHD6 -10223 10194
MGLL -9859 8492
ABHD12 -10050 93

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ABHD12 -10050 93
ABHD6 -10223 10194
DAGLA -1898 -11581
DAGLB -6291 -3166
MGLL -9859 8492



CD163 mediating an anti-inflammatory response
CD163 mediating an anti-inflammatory response
metric value
setSize 9
pMANOVA 0.00013
p.adjustMANOVA 0.000746
s.dist 0.753
s.crp_eos_adj 0.032
s.dex_eos_adj 0.752
p.crp_eos_adj 0.868
p.dex_eos_adj 9.37e-05



Top 20 genes
Gene crp_eos_adj dex_eos_adj
IL10 10611 8866
FURIN 6118 9002
MYH9 2076 8162
MAPK14 10775 1556
IL6 1370 4947

Click HERE to show all gene set members

All member genes
crp_eos_adj dex_eos_adj
ADAM17 -5972 9713
CD163 -10146 10250
FURIN 6118 9002
IL10 10611 8866
IL6 1370 4947
MAPK14 10775 1556
MYH9 2076 8162
PLK2 -2795 5596
RHBDF2 -4485 9629



Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}
## Network charts only generated in one-dimensional analysis.

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.5.3 (2026-03-11)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0  LAPACK version 3.10.0
## 
## locale:
## [1] C
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] gtools_3.9.5                xlsx_0.6.5                 
##  [3] DT_0.34.0                   eulerr_7.0.4               
##  [5] ggplot2_4.0.2               kableExtra_1.4.0           
##  [7] MASS_7.3-65                 mitch_1.21.3               
##  [9] DESeq2_1.50.2               SummarizedExperiment_1.40.0
## [11] Biobase_2.70.0              MatrixGenerics_1.22.0      
## [13] matrixStats_1.5.0           GenomicRanges_1.62.1       
## [15] Seqinfo_1.0.0               IRanges_2.44.0             
## [17] S4Vectors_0.48.0            BiocGenerics_0.56.0        
## [19] generics_0.1.4              dplyr_1.2.0                
## [21] WGCNA_1.73                  fastcluster_1.3.0          
## [23] dynamicTreeCut_1.63-1       reshape2_1.4.5             
## [25] gplots_3.2.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.1           memoise_2.0.1.9000    base64enc_0.1-6      
##  [10] progress_1.2.3        htmltools_0.5.9       S4Arrays_1.10.1      
##  [13] SparseArray_1.10.8    Formula_1.2-5         sass_0.4.10          
##  [16] KernSmooth_2.23-26    bslib_0.10.0          htmlwidgets_1.6.4    
##  [19] plyr_1.8.9            echarts4r_0.4.6       impute_1.83.0        
##  [22] cachem_1.1.0          mime_0.13             lifecycle_1.0.5      
##  [25] iterators_1.0.14      pkgconfig_2.0.3       Matrix_1.7-5         
##  [28] R6_2.6.1              fastmap_1.2.0         shiny_1.13.0         
##  [31] digest_0.6.39         colorspace_2.1-2      GGally_2.4.0         
##  [34] AnnotationDbi_1.71.0  textshaping_1.0.4     Hmisc_5.2-4          
##  [37] RSQLite_2.4.4         labeling_0.4.3        polyclip_1.10-7      
##  [40] httr_1.4.7            abind_1.4-8           compiler_4.5.3       
##  [43] withr_3.0.2           bit64_4.6.0-1         doParallel_1.0.17    
##  [46] htmlTable_2.4.3       S7_0.2.1              backports_1.5.0      
##  [49] BiocParallel_1.44.0   DBI_1.2.3             ggstats_0.11.0       
##  [52] DelayedArray_0.36.0   caTools_1.18.3        tools_4.5.3          
##  [55] foreign_0.8-91        otel_0.2.0            beeswarm_0.4.0       
##  [58] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [61] promises_1.5.0        polylabelr_0.3.0      grid_4.5.3           
##  [64] checkmate_2.3.3       cluster_2.1.8.2       gtable_0.3.6         
##  [67] preprocessCore_1.71.0 tidyr_1.3.2           hms_1.1.4            
##  [70] data.table_1.18.2.1   xml2_1.5.0            XVector_0.50.0       
##  [73] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [76] later_1.4.8           rJava_1.0-18          splines_4.5.3        
##  [79] lattice_0.22-7        survival_3.8-6        bit_4.6.0            
##  [82] tidyselect_1.2.1      GO.db_3.21.0          locfit_1.5-9.12      
##  [85] Biostrings_2.77.1     knitr_1.51            gridExtra_2.3        
##  [88] svglite_2.2.2         xfun_0.56             stringi_1.8.7        
##  [91] UCSC.utils_1.5.0      statnet.common_4.12.0 yaml_2.3.12          
##  [94] xlsxjars_0.9.0        evaluate_1.0.5        codetools_0.2-20     
##  [97] tibble_3.3.1          cli_3.6.5             rpart_4.1.27         
## [100] xtable_1.8-4          systemfonts_1.3.1     jquerylib_0.1.4      
## [103] network_1.19.0        dichromat_2.0-0.1     Rcpp_1.1.1           
## [106] GenomeInfoDb_1.45.4   coda_0.19-4.1         png_0.1-8            
## [109] parallel_4.5.3        blob_1.2.4            prettyunits_1.2.0    
## [112] bitops_1.0-9          viridisLite_0.4.3     scales_1.4.0         
## [115] purrr_1.2.1           crayon_1.5.3          rlang_1.1.7          
## [118] KEGGREST_1.49.0

END of report