Mitch Report

date generated: 2026-06-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	crp_pod1_adj	dex_pod1_adj
5_8S_rRNA	0.1666742	-1.6789077
A1BG	-1.0533790	0.4773455
A1BG-AS1	-0.2260155	-0.3881907
A1CF	1.1773563	0.3059609
A2M	1.7932114	-0.6340972
A2M-AS1	0.7455571	1.0223691

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	21253
duplicated_genes_present	0
num_profile_genes_in_sets	8700
num_profile_genes_not_in_sets	12553
profile_pearson_correl	-0.55009
profile_spearman_correl	-0.51476

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	2725
num_genesets_excluded	1198
num_genesets_included	1527

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 565

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_pod1_adj	s.dex_pod1_adj	p.crp_pod1_adj	p.dex_pod1_adj
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	1.64e-03	8.75e-03	1.020	0.814	-0.6100	5.54e-04	9.64e-03
Response to metal ions	6	2.02e-03	1.03e-02	1.010	0.774	-0.6570	1.03e-03	5.35e-03
G2/M DNA replication checkpoint	5	9.83e-03	3.72e-02	0.966	0.692	-0.6750	7.40e-03	8.99e-03
Fructose metabolism	7	2.81e-03	1.35e-02	0.912	-0.581	0.7030	7.78e-03	1.27e-03
CD163 mediating an anti-inflammatory response	8	1.61e-06	2.07e-05	0.875	0.873	0.0579	1.91e-05	7.77e-01
Butyrophilin (BTN) family interactions	10	7.72e-04	4.51e-03	0.849	-0.575	0.6250	1.64e-03	6.21e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	4.57e-03	1.99e-02	0.843	0.456	-0.7080	3.65e-02	1.17e-03
Fructose catabolism	5	2.86e-02	8.21e-02	0.827	-0.486	0.6680	5.97e-02	9.65e-03
Regulation of IFNA/IFNB signaling	12	2.03e-04	1.45e-03	0.810	0.441	-0.6790	8.20e-03	4.63e-05
Type I hemidesmosome assembly	8	5.83e-03	2.36e-02	0.806	0.566	-0.5740	5.60e-03	4.92e-03
Activation of caspases through apoptosome-mediated cleavage	6	1.83e-03	9.57e-03	0.794	0.144	-0.7810	5.42e-01	9.26e-04
Inhibition of Signaling by Overexpressed EGFR	5	4.08e-04	2.59e-03	0.780	0.753	0.2020	3.54e-03	4.33e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	4.08e-04	2.59e-03	0.780	0.753	0.2020	3.54e-03	4.33e-01
Establishment of Sister Chromatid Cohesion	11	3.91e-04	2.54e-03	0.770	0.344	-0.6900	4.84e-02	7.48e-05
Maturation of protein 3a 9683673	9	4.45e-03	1.95e-02	0.762	0.454	-0.6120	1.84e-02	1.46e-03
Maturation of protein 3a 9694719	9	4.45e-03	1.95e-02	0.762	0.454	-0.6120	1.84e-02	1.46e-03
ARMS-mediated activation	6	1.64e-02	5.39e-02	0.762	0.351	-0.6760	1.36e-01	4.15e-03
Acetylcholine binding and downstream events	5	4.36e-02	1.12e-01	0.759	0.640	-0.4090	1.33e-02	1.14e-01
Postsynaptic nicotinic acetylcholine receptors	5	4.36e-02	1.12e-01	0.759	0.640	-0.4090	1.33e-02	1.14e-01
Neurotransmitter clearance	6	5.46e-03	2.25e-02	0.755	-0.192	0.7300	4.16e-01	1.96e-03
Protein repair	6	2.26e-02	6.83e-02	0.751	0.382	-0.6460	1.05e-01	6.10e-03
Formation of xylulose-5-phosphate	5	1.56e-02	5.21e-02	0.750	-0.720	0.2090	5.28e-03	4.18e-01
Synthesis of diphthamide-EEF2	8	7.19e-03	2.83e-02	0.748	-0.637	0.3930	1.81e-03	5.41e-02
NFE2L2 regulates pentose phosphate pathway genes	8	1.97e-03	1.02e-02	0.734	0.701	-0.2180	5.94e-04	2.85e-01
Formation of a pool of free 40S subunits	100	4.01e-32	1.28e-29	0.733	-0.686	0.2580	1.71e-32	8.40e-06
Peptide chain elongation	88	4.69e-28	6.44e-26	0.732	-0.683	0.2630	1.39e-28	2.05e-05
Interleukin-21 signaling	9	2.95e-03	1.39e-02	0.731	0.321	-0.6570	9.58e-02	6.45e-04
Mitotic Telophase/Cytokinesis	13	1.04e-03	5.83e-03	0.721	0.448	-0.5650	5.16e-03	4.21e-04
Eukaryotic Translation Elongation	93	1.13e-28	1.82e-26	0.718	-0.671	0.2540	3.94e-29	2.31e-05
Selenocysteine synthesis	92	5.12e-28	6.55e-26	0.711	-0.666	0.2480	2.01e-28	4.03e-05
SARS-CoV-1 modulates host translation machinery	36	5.44e-11	1.29e-09	0.708	-0.656	0.2660	9.11e-12	5.74e-03
Viral mRNA Translation	88	2.31e-26	2.11e-24	0.697	-0.658	0.2320	1.31e-26	1.68e-04
Eukaryotic Translation Termination	92	2.94e-27	3.14e-25	0.694	-0.655	0.2320	1.70e-27	1.21e-04
EGFR interacts with phospholipase C-gamma	6	4.50e-04	2.85e-03	0.692	0.655	0.2240	5.49e-03	3.42e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	8.84e-02	1.87e-01	0.688	0.418	-0.5460	1.06e-01	3.45e-02
Platelet sensitization by LDL	16	5.20e-04	3.18e-03	0.685	0.436	-0.5270	2.50e-03	2.59e-04
RUNX3 regulates CDKN1A transcription	7	3.02e-02	8.62e-02	0.685	-0.383	0.5680	7.95e-02	9.30e-03
Interleukin-6 signaling	10	4.73e-03	2.04e-02	0.683	0.332	-0.5970	6.90e-02	1.08e-03
RUNX1 regulates transcription of genes involved in BCR signaling	6	4.28e-02	1.11e-01	0.682	0.590	-0.3420	1.23e-02	1.47e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	6.33e-02	1.47e-01	0.679	0.506	-0.4530	3.17e-02	5.47e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	2.97e-26	2.59e-24	0.679	-0.637	0.2350	1.16e-26	8.33e-05
L13a-mediated translational silencing of Ceruloplasmin expression	110	1.92e-31	4.09e-29	0.679	-0.642	0.2190	2.14e-31	7.20e-05
Formation of the ternary complex, and subsequently, the 43S complex	51	4.40e-15	1.76e-13	0.679	-0.644	0.2150	1.77e-15	7.89e-03
Scavenging by Class F Receptors	5	1.05e-01	2.13e-01	0.674	0.487	-0.4660	5.94e-02	7.11e-02
Ethanol oxidation	6	5.20e-02	1.27e-01	0.672	-0.568	0.3580	1.60e-02	1.29e-01
MET activates PI3K/AKT signaling	5	1.10e-01	2.17e-01	0.668	0.486	-0.4580	6.00e-02	7.61e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	4.57e-02	1.16e-01	0.667	0.459	-0.4830	3.53e-02	2.68e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.45e-30	2.53e-28	0.666	-0.630	0.2140	1.54e-30	9.51e-05
Cap-dependent Translation Initiation	118	7.57e-32	1.82e-29	0.665	-0.626	0.2220	5.64e-32	2.99e-05
Eukaryotic Translation Initiation	118	7.57e-32	1.82e-29	0.665	-0.626	0.2220	5.64e-32	2.99e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.crp_pod1_adj	s.dex_pod1_adj	p.crp_pod1_adj	p.dex_pod1_adj
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	6	1.64e-03	8.75e-03	1.02000	0.814000	-6.10e-01	5.54e-04	9.64e-03
Response to metal ions	6	2.02e-03	1.03e-02	1.01000	0.774000	-6.57e-01	1.03e-03	5.35e-03
G2/M DNA replication checkpoint	5	9.83e-03	3.72e-02	0.96600	0.692000	-6.75e-01	7.40e-03	8.99e-03
Fructose metabolism	7	2.81e-03	1.35e-02	0.91200	-0.581000	7.03e-01	7.78e-03	1.27e-03
CD163 mediating an anti-inflammatory response	8	1.61e-06	2.07e-05	0.87500	0.873000	5.79e-02	1.91e-05	7.77e-01
Butyrophilin (BTN) family interactions	10	7.72e-04	4.51e-03	0.84900	-0.575000	6.25e-01	1.64e-03	6.21e-04
Activation of NIMA Kinases NEK9, NEK6, NEK7	7	4.57e-03	1.99e-02	0.84300	0.456000	-7.08e-01	3.65e-02	1.17e-03
Fructose catabolism	5	2.86e-02	8.21e-02	0.82700	-0.486000	6.68e-01	5.97e-02	9.65e-03
Regulation of IFNA/IFNB signaling	12	2.03e-04	1.45e-03	0.81000	0.441000	-6.79e-01	8.20e-03	4.63e-05
Type I hemidesmosome assembly	8	5.83e-03	2.36e-02	0.80600	0.566000	-5.74e-01	5.60e-03	4.92e-03
Activation of caspases through apoptosome-mediated cleavage	6	1.83e-03	9.57e-03	0.79400	0.144000	-7.81e-01	5.42e-01	9.26e-04
Inhibition of Signaling by Overexpressed EGFR	5	4.08e-04	2.59e-03	0.78000	0.753000	2.02e-01	3.54e-03	4.33e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer	5	4.08e-04	2.59e-03	0.78000	0.753000	2.02e-01	3.54e-03	4.33e-01
Establishment of Sister Chromatid Cohesion	11	3.91e-04	2.54e-03	0.77000	0.344000	-6.90e-01	4.84e-02	7.48e-05
Maturation of protein 3a 9683673	9	4.45e-03	1.95e-02	0.76200	0.454000	-6.12e-01	1.84e-02	1.46e-03
Maturation of protein 3a 9694719	9	4.45e-03	1.95e-02	0.76200	0.454000	-6.12e-01	1.84e-02	1.46e-03
ARMS-mediated activation	6	1.64e-02	5.39e-02	0.76200	0.351000	-6.76e-01	1.36e-01	4.15e-03
Acetylcholine binding and downstream events	5	4.36e-02	1.12e-01	0.75900	0.640000	-4.09e-01	1.33e-02	1.14e-01
Postsynaptic nicotinic acetylcholine receptors	5	4.36e-02	1.12e-01	0.75900	0.640000	-4.09e-01	1.33e-02	1.14e-01
Neurotransmitter clearance	6	5.46e-03	2.25e-02	0.75500	-0.192000	7.30e-01	4.16e-01	1.96e-03
Protein repair	6	2.26e-02	6.83e-02	0.75100	0.382000	-6.46e-01	1.05e-01	6.10e-03
Formation of xylulose-5-phosphate	5	1.56e-02	5.21e-02	0.75000	-0.720000	2.09e-01	5.28e-03	4.18e-01
Synthesis of diphthamide-EEF2	8	7.19e-03	2.83e-02	0.74800	-0.637000	3.93e-01	1.81e-03	5.41e-02
NFE2L2 regulates pentose phosphate pathway genes	8	1.97e-03	1.02e-02	0.73400	0.701000	-2.18e-01	5.94e-04	2.85e-01
Formation of a pool of free 40S subunits	100	4.01e-32	1.28e-29	0.73300	-0.686000	2.58e-01	1.71e-32	8.40e-06
Peptide chain elongation	88	4.69e-28	6.44e-26	0.73200	-0.683000	2.63e-01	1.39e-28	2.05e-05
Interleukin-21 signaling	9	2.95e-03	1.39e-02	0.73100	0.321000	-6.57e-01	9.58e-02	6.45e-04
Mitotic Telophase/Cytokinesis	13	1.04e-03	5.83e-03	0.72100	0.448000	-5.65e-01	5.16e-03	4.21e-04
Eukaryotic Translation Elongation	93	1.13e-28	1.82e-26	0.71800	-0.671000	2.54e-01	3.94e-29	2.31e-05
Selenocysteine synthesis	92	5.12e-28	6.55e-26	0.71100	-0.666000	2.48e-01	2.01e-28	4.03e-05
SARS-CoV-1 modulates host translation machinery	36	5.44e-11	1.29e-09	0.70800	-0.656000	2.66e-01	9.11e-12	5.74e-03
Viral mRNA Translation	88	2.31e-26	2.11e-24	0.69700	-0.658000	2.32e-01	1.31e-26	1.68e-04
Eukaryotic Translation Termination	92	2.94e-27	3.14e-25	0.69400	-0.655000	2.32e-01	1.70e-27	1.21e-04
EGFR interacts with phospholipase C-gamma	6	4.50e-04	2.85e-03	0.69200	0.655000	2.24e-01	5.49e-03	3.42e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	5	8.84e-02	1.87e-01	0.68800	0.418000	-5.46e-01	1.06e-01	3.45e-02
Platelet sensitization by LDL	16	5.20e-04	3.18e-03	0.68500	0.436000	-5.27e-01	2.50e-03	2.59e-04
RUNX3 regulates CDKN1A transcription	7	3.02e-02	8.62e-02	0.68500	-0.383000	5.68e-01	7.95e-02	9.30e-03
Interleukin-6 signaling	10	4.73e-03	2.04e-02	0.68300	0.332000	-5.97e-01	6.90e-02	1.08e-03
RUNX1 regulates transcription of genes involved in BCR signaling	6	4.28e-02	1.11e-01	0.68200	0.590000	-3.42e-01	1.23e-02	1.47e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	6	6.33e-02	1.47e-01	0.67900	0.506000	-4.53e-01	3.17e-02	5.47e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	2.97e-26	2.59e-24	0.67900	-0.637000	2.35e-01	1.16e-26	8.33e-05
L13a-mediated translational silencing of Ceruloplasmin expression	110	1.92e-31	4.09e-29	0.67900	-0.642000	2.19e-01	2.14e-31	7.20e-05
Formation of the ternary complex, and subsequently, the 43S complex	51	4.40e-15	1.76e-13	0.67900	-0.644000	2.15e-01	1.77e-15	7.89e-03
Scavenging by Class F Receptors	5	1.05e-01	2.13e-01	0.67400	0.487000	-4.66e-01	5.94e-02	7.11e-02
Ethanol oxidation	6	5.20e-02	1.27e-01	0.67200	-0.568000	3.58e-01	1.60e-02	1.29e-01
MET activates PI3K/AKT signaling	5	1.10e-01	2.17e-01	0.66800	0.486000	-4.58e-01	6.00e-02	7.61e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	7	4.57e-02	1.16e-01	0.66700	0.459000	-4.83e-01	3.53e-02	2.68e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.45e-30	2.53e-28	0.66600	-0.630000	2.14e-01	1.54e-30	9.51e-05
Cap-dependent Translation Initiation	118	7.57e-32	1.82e-29	0.66500	-0.626000	2.22e-01	5.64e-32	2.99e-05
Eukaryotic Translation Initiation	118	7.57e-32	1.82e-29	0.66500	-0.626000	2.22e-01	5.64e-32	2.99e-05
Phenylalanine metabolism	5	1.05e-01	2.12e-01	0.66400	-0.526000	4.05e-01	4.18e-02	1.17e-01
Cohesin Loading onto Chromatin	10	1.09e-02	4.01e-02	0.66000	0.390000	-5.32e-01	3.27e-02	3.59e-03
N-Glycan antennae elongation	12	5.71e-03	2.32e-02	0.65900	0.473000	-4.60e-01	4.57e-03	5.84e-03
ROBO receptors bind AKAP5	7	2.30e-02	6.91e-02	0.65300	0.264000	-5.97e-01	2.26e-01	6.19e-03
Erythrocytes take up oxygen and release carbon dioxide	7	1.55e-02	5.18e-02	0.64300	0.614000	-1.93e-01	4.92e-03	3.75e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	5	4.04e-02	1.06e-01	0.64200	-0.152000	6.24e-01	5.56e-01	1.57e-02
SMAC (DIABLO) binds to IAPs	7	2.94e-03	1.39e-02	0.64100	0.004120	-6.41e-01	9.85e-01	3.31e-03
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	7	2.94e-03	1.39e-02	0.64100	0.004120	-6.41e-01	9.85e-01	3.31e-03
SMAC, XIAP-regulated apoptotic response	7	2.94e-03	1.39e-02	0.64100	0.004120	-6.41e-01	9.85e-01	3.31e-03
Common Pathway of Fibrin Clot Formation	13	5.18e-03	2.16e-02	0.64000	0.449000	-4.56e-01	5.08e-03	4.45e-03
rRNA modification in the mitochondrion	8	1.24e-03	6.80e-03	0.63900	-0.639000	-2.26e-03	1.74e-03	9.91e-01
Regulation of TP53 Activity through Association with Co-factors	11	2.71e-03	1.32e-02	0.63800	-0.235000	5.93e-01	1.78e-01	6.61e-04
RHOT1 GTPase cycle	5	9.43e-02	1.95e-01	0.63700	0.561000	-3.03e-01	2.98e-02	2.41e-01
Condensation of Prometaphase Chromosomes	11	5.11e-03	2.14e-02	0.63400	0.287000	-5.66e-01	9.98e-02	1.16e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	5.61e-15	2.20e-13	0.63200	-0.598000	2.06e-01	1.91e-15	6.09e-03
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5	8.11e-02	1.75e-01	0.63100	-0.577000	2.56e-01	2.55e-02	3.21e-01
Phosphorylation of Emi1	6	9.59e-02	1.97e-01	0.62800	0.435000	-4.53e-01	6.51e-02	5.46e-02
Netrin mediated repulsion signals	5	1.32e-01	2.49e-01	0.62400	0.505000	-3.66e-01	5.04e-02	1.56e-01
Translation initiation complex formation	58	1.34e-14	4.68e-13	0.62300	-0.592000	1.94e-01	5.79e-15	1.06e-02
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	6	7.78e-02	1.70e-01	0.62300	0.331000	-5.28e-01	1.61e-01	2.50e-02
Regulation of IFNG signaling	14	3.86e-03	1.76e-02	0.62300	0.381000	-4.93e-01	1.36e-02	1.41e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	6.05e-24	4.47e-22	0.62200	-0.587000	2.05e-01	3.24e-24	4.01e-04
Interaction between L1 and Ankyrins	26	3.58e-05	3.26e-04	0.62100	0.490000	-3.80e-01	1.50e-05	7.84e-04
Defective GALNT3 causes HFTC	8	1.48e-02	5.04e-02	0.62000	0.583000	-2.10e-01	4.30e-03	3.04e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	4.39e-03	1.94e-02	0.61900	0.389000	-4.81e-01	1.16e-02	1.84e-03
Cytosolic iron-sulfur cluster assembly	13	5.01e-03	2.12e-02	0.61500	-0.336000	5.15e-01	3.57e-02	1.31e-03
Wax and plasmalogen biosynthesis	5	3.22e-02	9.03e-02	0.61500	0.065100	-6.11e-01	8.01e-01	1.79e-02
RHO GTPases activate IQGAPs	25	5.09e-05	4.37e-04	0.61300	0.502000	-3.51e-01	1.38e-05	2.36e-03
Ribosomal scanning and start codon recognition	58	7.47e-14	2.29e-12	0.61200	-0.579000	2.00e-01	2.39e-14	8.43e-03
Termination of O-glycan biosynthesis	15	2.76e-03	1.33e-02	0.61100	0.501000	-3.50e-01	7.89e-04	1.90e-02
STAT5 activation downstream of FLT3 ITD mutants	9	6.00e-03	2.42e-02	0.61000	0.590000	-1.53e-01	2.17e-03	4.26e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	3.88e-04	2.53e-03	0.61000	0.578000	-1.93e-01	1.05e-04	1.96e-01
Signaling by PDGFRA extracellular domain mutants	12	1.01e-02	3.78e-02	0.60800	0.363000	-4.88e-01	2.94e-02	3.41e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	1.01e-02	3.78e-02	0.60800	0.363000	-4.88e-01	2.94e-02	3.41e-03
EGFR Transactivation by Gastrin	7	7.02e-02	1.57e-01	0.60500	0.487000	-3.58e-01	2.55e-02	1.01e-01
G2 Phase	5	1.64e-01	2.87e-01	0.60200	0.448000	-4.03e-01	8.30e-02	1.19e-01
Regulation of RUNX1 Expression and Activity	18	1.05e-03	5.90e-03	0.59900	0.338000	-4.95e-01	1.31e-02	2.79e-04
Selenoamino acid metabolism	115	2.65e-24	2.03e-22	0.59600	-0.556000	2.16e-01	6.37e-25	6.14e-05
POLB-Dependent Long Patch Base Excision Repair	8	1.47e-02	4.99e-02	0.59500	-0.572000	1.61e-01	5.05e-03	4.31e-01
Regulation of NFE2L2 gene expression	8	2.17e-03	1.09e-02	0.59200	0.590000	4.23e-02	3.85e-03	8.36e-01
Relaxin receptors	5	3.13e-02	8.86e-02	0.59200	0.591000	-1.69e-02	2.20e-02	9.48e-01
SARS-CoV-2 modulates host translation machinery	49	1.20e-10	2.71e-09	0.59100	-0.552000	2.13e-01	2.32e-11	9.98e-03
GDP-fucose biosynthesis	6	1.23e-01	2.36e-01	0.59000	-0.380000	4.51e-01	1.07e-01	5.56e-02
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5	3.81e-02	1.02e-01	0.59000	-0.588000	4.50e-02	2.28e-02	8.62e-01
ChREBP activates metabolic gene expression	7	9.12e-02	1.91e-01	0.58800	0.425000	-4.05e-01	5.13e-02	6.33e-02
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7	6.92e-02	1.56e-01	0.57700	-0.504000	2.81e-01	2.10e-02	1.98e-01
Defects in biotin (Btn) metabolism	8	3.15e-02	8.92e-02	0.57700	-0.533000	2.20e-01	9.03e-03	2.81e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	9	1.21e-02	4.35e-02	0.57600	0.161000	-5.54e-01	4.03e-01	4.03e-03
Mitochondrial translation initiation	90	5.78e-23	3.83e-21	0.57500	-0.568000	8.76e-02	1.09e-20	1.51e-01
SRP-dependent cotranslational protein targeting to membrane	111	1.11e-27	1.25e-25	0.57200	-0.565000	9.01e-02	7.73e-25	1.01e-01
Signaling by LTK in cancer	7	1.03e-01	2.10e-01	0.57200	0.417000	-3.91e-01	5.62e-02	7.30e-02
Mitochondrial translation elongation	90	1.55e-21	9.02e-20	0.57000	-0.559000	1.11e-01	4.25e-20	6.94e-02
Regulation of NPAS4 gene expression	11	1.68e-02	5.48e-02	0.57000	0.279000	-4.97e-01	1.09e-01	4.31e-03
GAB1 signalosome	14	7.23e-04	4.25e-03	0.57000	0.556000	-1.25e-01	3.15e-04	4.18e-01
Major pathway of rRNA processing in the nucleolus and cytosol	179	6.03e-33	2.32e-30	0.56800	-0.524000	2.20e-01	9.59e-34	3.70e-07
Interleukin-20 family signaling	17	2.13e-03	1.08e-02	0.56800	0.289000	-4.89e-01	3.94e-02	4.75e-04
Vitamin B1 (thiamin) metabolism	5	1.35e-01	2.54e-01	0.56700	-0.515000	2.37e-01	4.59e-02	3.60e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	8.49e-24	5.82e-22	0.56700	-0.542000	1.65e-01	1.39e-23	2.37e-03
Nonsense-Mediated Decay (NMD)	114	8.49e-24	5.82e-22	0.56700	-0.542000	1.65e-01	1.39e-23	2.37e-03
rRNA processing in the nucleus and cytosol	189	2.32e-34	1.49e-31	0.56500	-0.521000	2.19e-01	3.74e-35	2.02e-07
Sodium/Proton exchangers	7	9.43e-02	1.95e-01	0.56400	0.465000	-3.20e-01	3.32e-02	1.43e-01
Tandem pore domain potassium channels	5	2.02e-01	3.30e-01	0.56400	0.362000	-4.33e-01	1.61e-01	9.40e-02
Signaling by FLT3 ITD and TKD mutants	15	4.21e-03	1.88e-02	0.56300	0.493000	-2.71e-01	9.51e-04	6.87e-02
Formation of the nephric duct	8	8.14e-02	1.76e-01	0.56200	0.408000	-3.88e-01	4.59e-02	5.76e-02
Metabolism of ingested SeMet, Sec, MeSec into H2Se	7	3.66e-02	9.89e-02	0.56000	-0.147000	5.40e-01	5.02e-01	1.33e-02
Mitochondrial translation termination	90	3.92e-21	2.21e-19	0.56000	-0.551000	1.00e-01	1.65e-19	1.01e-01
Mitochondrial translation	96	2.01e-22	1.25e-20	0.55900	-0.550000	1.01e-01	1.12e-20	8.66e-02
Regulation of gene expression by Hypoxia-inducible Factor	8	1.45e-02	4.94e-02	0.55900	0.551000	-9.40e-02	6.92e-03	6.45e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.50e-02	5.08e-02	0.55800	0.330000	-4.49e-01	3.91e-02	5.01e-03
Synthesis of wybutosine at G37 of tRNA(Phe)	6	2.65e-02	7.72e-02	0.55700	-0.556000	2.35e-02	1.83e-02	9.21e-01
Synthesis of UDP-N-acetyl-glucosamine	8	4.48e-02	1.15e-01	0.55500	-0.507000	2.25e-01	1.30e-02	2.70e-01
Diseases of Mismatch Repair (MMR)	5	4.40e-02	1.13e-01	0.55400	0.001390	-5.54e-01	9.96e-01	3.19e-02
Influenza Viral RNA Transcription and Replication	135	5.69e-25	4.55e-23	0.55300	-0.519000	1.91e-01	2.07e-25	1.22e-04
OAS antiviral response	8	2.89e-03	1.38e-02	0.55000	-0.099300	-5.41e-01	6.27e-01	8.02e-03
G0 and Early G1	27	1.73e-04	1.27e-03	0.55000	0.310000	-4.54e-01	5.36e-03	4.39e-05
Complex III assembly	23	3.73e-04	2.45e-03	0.54900	-0.478000	2.71e-01	7.30e-05	2.45e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	2.96e-02	8.46e-02	0.54600	0.252000	-4.84e-01	1.67e-01	7.98e-03
GRB2 events in EGFR signaling	10	5.57e-03	2.29e-02	0.54500	0.540000	-7.76e-02	3.11e-03	6.71e-01
ALK mutants bind TKIs	11	3.47e-02	9.50e-02	0.54400	0.327000	-4.35e-01	6.00e-02	1.25e-02
RUNX3 regulates WNT signaling	8	7.68e-02	1.68e-01	0.54200	0.458000	-2.90e-01	2.48e-02	1.55e-01
Sulfide oxidation to sulfate	5	1.77e-01	3.02e-01	0.54200	-0.481000	2.50e-01	6.27e-02	3.32e-01
Caspase activation via Dependence Receptors in the absence of ligand	9	7.34e-02	1.63e-01	0.54100	0.371000	-3.93e-01	5.37e-02	4.10e-02
RHO GTPases activate KTN1	11	3.36e-02	9.30e-02	0.54000	0.444000	-3.08e-01	1.07e-02	7.73e-02
Regulation of CDH19 Expression and Function	5	1.32e-02	4.60e-02	0.54000	0.280000	4.61e-01	2.78e-01	7.41e-02
Biosynthesis of Lipoxins (LX)	6	7.61e-02	1.67e-01	0.53800	0.517000	-1.49e-01	2.82e-02	5.27e-01
NFE2L2 regulating tumorigenic genes	11	2.88e-03	1.38e-02	0.53800	0.536000	-5.27e-02	2.09e-03	7.62e-01
Polo-like kinase mediated events	16	9.50e-03	3.60e-02	0.53500	0.335000	-4.18e-01	2.05e-02	3.79e-03
RHO GTPases Activate NADPH Oxidases	21	2.23e-03	1.11e-02	0.53500	0.334000	-4.18e-01	8.09e-03	9.06e-04
Beta oxidation of butanoyl-CoA to acetyl-CoA	5	2.39e-01	3.68e-01	0.53500	-0.404000	3.51e-01	1.18e-01	1.74e-01
Defective HLCS causes multiple carboxylase deficiency	7	8.31e-02	1.78e-01	0.53400	-0.486000	2.21e-01	2.61e-02	3.10e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6	5.03e-02	1.23e-01	0.53300	-0.528000	7.40e-02	2.51e-02	7.54e-01
APOBEC3G mediated resistance to HIV-1 infection	5	4.90e-02	1.21e-01	0.53200	-0.531000	-2.31e-02	3.96e-02	9.29e-01
rRNA processing	213	6.46e-34	3.10e-31	0.53000	-0.488000	2.06e-01	9.89e-35	2.06e-07
Propionyl-CoA catabolism	5	1.12e-01	2.20e-01	0.52900	-0.515000	1.24e-01	4.63e-02	6.31e-01
Interleukin-9 signaling	8	7.16e-02	1.60e-01	0.52900	0.244000	-4.69e-01	2.31e-01	2.17e-02
Post-transcriptional silencing by small RNAs	7	1.35e-01	2.54e-01	0.52700	0.318000	-4.20e-01	1.45e-01	5.44e-02
Kidney development	16	1.27e-02	4.48e-02	0.52400	0.389000	-3.51e-01	7.06e-03	1.51e-02
Ca2+ activated K+ channels	6	3.81e-02	1.02e-01	0.52200	-0.011200	5.22e-01	9.62e-01	2.67e-02
Signaling by PDGFR in disease	19	2.70e-03	1.32e-02	0.51800	0.246000	-4.56e-01	6.38e-02	5.86e-04
Maturation of spike protein 9683686	5	2.66e-01	3.94e-01	0.51700	-0.369000	3.62e-01	1.53e-01	1.61e-01
Phase 4 - resting membrane potential	9	8.87e-02	1.88e-01	0.51700	0.398000	-3.30e-01	3.89e-02	8.63e-02
Toxicity of botulinum toxin type D (botD)	5	2.04e-01	3.31e-01	0.51700	-0.234000	4.60e-01	3.64e-01	7.46e-02
Toxicity of botulinum toxin type F (botF)	5	2.04e-01	3.31e-01	0.51700	-0.234000	4.60e-01	3.64e-01	7.46e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.90e-02	6.02e-02	0.51600	-0.484000	1.81e-01	5.46e-03	2.99e-01
CD22 mediated BCR regulation	58	1.20e-08	2.16e-07	0.51600	0.237000	-4.58e-01	1.81e-03	1.55e-09
RUNX3 regulates BCL2L11 (BIM) transcription	5	2.13e-01	3.41e-01	0.51600	-0.245000	4.54e-01	3.43e-01	7.88e-02
tRNA modification in the mitochondrion	9	9.31e-02	1.94e-01	0.51500	-0.378000	3.51e-01	4.98e-02	6.82e-02
Cobalamin (Cbl) metabolism	7	2.43e-02	7.18e-02	0.51100	0.002170	-5.11e-01	9.92e-01	1.91e-02
Reduction of cytosolic Ca++ levels	9	8.88e-02	1.88e-01	0.50900	0.410000	-3.02e-01	3.31e-02	1.17e-01
Defective C1GALT1C1 causes TNPS	9	6.15e-02	1.44e-01	0.50900	0.455000	-2.30e-01	1.82e-02	2.33e-01
Triglyceride catabolism	15	2.05e-02	6.35e-02	0.50800	0.330000	-3.87e-01	2.69e-02	9.49e-03
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5	6.80e-02	1.55e-01	0.50800	-0.508000	-1.00e-02	4.91e-02	9.69e-01
Displacement of DNA glycosylase by APEX1	9	6.39e-02	1.47e-01	0.50700	-0.452000	2.32e-01	1.90e-02	2.29e-01
Eicosanoids	6	9.77e-02	2.00e-01	0.50700	0.489000	-1.33e-01	3.80e-02	5.73e-01
FCGR activation	76	1.48e-11	3.84e-10	0.50600	0.197000	-4.66e-01	2.93e-03	2.18e-12
Methionine salvage pathway	6	5.71e-02	1.36e-01	0.50600	-0.504000	4.16e-02	3.26e-02	8.60e-01
Influenza Infection	154	3.31e-25	2.77e-23	0.50500	-0.482000	1.52e-01	4.70e-25	1.16e-03
Translation	293	5.27e-55	1.01e-51	0.50500	-0.497000	8.57e-02	9.10e-49	1.16e-02
Synthesis of glycosylphosphatidylinositol (GPI)	18	6.92e-03	2.75e-02	0.50500	-0.425000	2.72e-01	1.81e-03	4.55e-02
MASTL Facilitates Mitotic Progression	10	2.25e-02	6.83e-02	0.50400	0.136000	-4.85e-01	4.55e-01	7.86e-03
Induction of Cell-Cell Fusion	8	1.08e-01	2.15e-01	0.50200	0.428000	-2.61e-01	3.59e-02	2.01e-01
Role of LAT2/NTAL/LAB on calcium mobilization	77	1.07e-10	2.44e-09	0.50100	0.226000	-4.46e-01	5.92e-04	1.23e-11
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	5	1.23e-01	2.37e-01	0.50000	-0.088000	4.92e-01	7.33e-01	5.68e-02
Signaling by FLT3 fusion proteins	18	1.09e-02	4.01e-02	0.49900	0.385000	-3.18e-01	4.73e-03	1.95e-02
SLBP independent Processing of Histone Pre-mRNAs	10	3.71e-02	9.99e-02	0.49800	-0.464000	1.82e-01	1.11e-02	3.19e-01
Transcriptional regulation of testis differentiation	5	1.16e-01	2.25e-01	0.49800	-0.071300	4.92e-01	7.82e-01	5.65e-02
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6	1.53e-02	5.14e-02	0.49600	-0.452000	-2.05e-01	5.54e-02	3.84e-01
Axonal growth inhibition (RHOA activation)	7	1.10e-01	2.18e-01	0.49400	0.455000	-1.90e-01	3.70e-02	3.83e-01
p75NTR regulates axonogenesis	7	1.10e-01	2.18e-01	0.49400	0.455000	-1.90e-01	3.70e-02	3.83e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	3.45e-02	9.44e-02	0.49000	0.321000	-3.70e-01	3.73e-02	1.64e-02
RHO GTPases Activate WASPs and WAVEs	35	1.20e-04	9.31e-04	0.49000	0.270000	-4.09e-01	5.67e-03	2.79e-05
CS/DS degradation	9	9.62e-02	1.97e-01	0.49000	-0.266000	4.12e-01	1.68e-01	3.24e-02
SUMO is proteolytically processed	6	1.82e-02	5.83e-02	0.48900	-0.189000	-4.51e-01	4.22e-01	5.56e-02
Transcriptional regulation of granulopoiesis	44	2.39e-05	2.32e-04	0.48900	0.308000	-3.80e-01	4.13e-04	1.28e-05
Formyl peptide receptors bind formyl peptides and many other ligands	7	6.04e-02	1.41e-01	0.48800	0.084300	-4.81e-01	6.99e-01	2.76e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	83	1.83e-10	4.08e-09	0.48700	0.239000	-4.24e-01	1.68e-04	2.29e-11
Regulation of PTEN mRNA translation	12	4.06e-02	1.06e-01	0.48500	0.242000	-4.21e-01	1.47e-01	1.16e-02
Scavenging of heme from plasma	70	4.20e-09	8.15e-08	0.48500	0.227000	-4.29e-01	1.04e-03	5.29e-10
SHC1 events in EGFR signaling	11	1.22e-02	4.38e-02	0.48400	0.478000	-7.74e-02	6.05e-03	6.57e-01
CHL1 interactions	8	1.49e-01	2.71e-01	0.48400	0.378000	-3.02e-01	6.42e-02	1.39e-01
PI3K/AKT activation	8	7.00e-02	1.57e-01	0.48400	0.460000	-1.50e-01	2.43e-02	4.62e-01
Tight junction interactions	17	1.83e-02	5.85e-02	0.48300	-0.373000	3.07e-01	7.79e-03	2.83e-02
Signaling by RNF43 mutants	7	1.15e-01	2.24e-01	0.48300	0.449000	-1.77e-01	3.95e-02	4.19e-01
DNA replication initiation	8	1.20e-01	2.32e-01	0.48300	-0.420000	2.38e-01	3.97e-02	2.44e-01
G1/S-Specific Transcription	29	2.38e-04	1.66e-03	0.48200	0.203000	-4.37e-01	5.88e-02	4.54e-05
Prolonged ERK activation events	13	4.89e-02	1.21e-01	0.48200	0.314000	-3.65e-01	4.98e-02	2.27e-02
FCGR3A-mediated phagocytosis	121	7.76e-15	2.87e-13	0.48100	0.228000	-4.24e-01	1.44e-05	7.75e-16
Leishmania phagocytosis	121	7.76e-15	2.87e-13	0.48100	0.228000	-4.24e-01	1.44e-05	7.75e-16
Parasite infection	121	7.76e-15	2.87e-13	0.48100	0.228000	-4.24e-01	1.44e-05	7.75e-16
Formation of the active cofactor, UDP-glucuronate	5	2.36e-01	3.66e-01	0.48100	0.200000	-4.38e-01	4.40e-01	8.99e-02
Role of ABL in ROBO-SLIT signaling	6	2.29e-01	3.59e-01	0.48000	0.398000	-2.70e-01	9.17e-02	2.52e-01
Mitochondrial protein import	63	1.61e-09	3.32e-08	0.47900	-0.454000	1.54e-01	4.56e-10	3.47e-02
CREB phosphorylation	7	8.27e-02	1.78e-01	0.47900	0.115000	-4.65e-01	5.99e-01	3.31e-02
Antimicrobial peptides	33	5.71e-04	3.41e-03	0.47800	0.342000	-3.34e-01	6.62e-04	8.99e-04
RUNX1 regulates transcription of genes involved in WNT signaling	5	3.25e-01	4.57e-01	0.47600	0.348000	-3.25e-01	1.78e-01	2.08e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7	8.39e-03	3.23e-02	0.47600	-0.394000	-2.66e-01	7.08e-02	2.22e-01
FCERI mediated Ca+2 mobilization	92	2.33e-11	5.81e-10	0.47600	0.220000	-4.22e-01	2.69e-04	2.61e-12
RUNX1 regulates estrogen receptor mediated transcription	6	2.53e-01	3.82e-01	0.47500	0.297000	-3.71e-01	2.08e-01	1.15e-01
SUMO is conjugated to E1 (UBA2:SAE1)	5	3.56e-02	9.68e-02	0.47500	-0.240000	-4.10e-01	3.52e-01	1.13e-01
Processing of SMDT1	15	2.58e-03	1.27e-02	0.47500	-0.470000	6.27e-02	1.61e-03	6.74e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.26e-02	6.83e-02	0.47400	0.319000	-3.50e-01	2.27e-02	1.25e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.26e-02	6.83e-02	0.47400	0.319000	-3.50e-01	2.27e-02	1.25e-02
NFE2L2 regulating MDR associated enzymes	8	3.63e-02	9.84e-02	0.47300	0.471000	-4.24e-02	2.10e-02	8.36e-01
RUNX1 regulates expression of components of tight junctions	5	3.25e-01	4.57e-01	0.47300	0.361000	-3.06e-01	1.62e-01	2.37e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	6.90e-04	4.11e-03	0.47300	0.255000	-3.98e-01	1.56e-02	1.60e-04
Signal attenuation	9	1.37e-02	4.75e-02	0.47300	0.472000	2.10e-02	1.42e-02	9.13e-01
Reelin signalling pathway	5	2.21e-01	3.49e-01	0.47200	0.164000	-4.43e-01	5.25e-01	8.65e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	5.32e-03	2.21e-02	0.47200	0.133000	-4.52e-01	3.57e-01	1.73e-03
N-glycan antennae elongation in the medial/trans-Golgi	20	1.22e-02	4.38e-02	0.47100	0.323000	-3.43e-01	1.24e-02	7.90e-03
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	1.23e-02	4.40e-02	0.47000	0.427000	-1.97e-01	3.09e-03	1.73e-01
Platelet Adhesion to exposed collagen	14	4.19e-02	1.08e-01	0.46900	0.375000	-2.82e-01	1.52e-02	6.75e-02
Platelet calcium homeostasis	22	7.18e-03	2.83e-02	0.46900	0.369000	-2.89e-01	2.71e-03	1.89e-02
Regulation of actin dynamics for phagocytic cup formation	123	7.85e-14	2.35e-12	0.46900	0.238000	-4.04e-01	5.27e-06	9.94e-15
Nephrin family interactions	19	1.63e-02	5.34e-02	0.46800	0.328000	-3.34e-01	1.34e-02	1.17e-02
rRNA modification in the nucleus and cytosol	59	1.69e-07	2.60e-06	0.46800	-0.420000	2.06e-01	2.37e-08	6.15e-03
Translocation of ZAP-70 to Immunological synapse	24	3.92e-04	2.54e-03	0.46500	-0.449000	1.21e-01	1.40e-04	3.05e-01
Linoleic acid (LA) metabolism	7	1.62e-01	2.85e-01	0.46400	0.417000	-2.05e-01	5.63e-02	3.48e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	1.01e-02	3.78e-02	0.46300	-0.455000	8.78e-02	4.52e-03	5.83e-01
Thyroxine biosynthesis	5	2.05e-01	3.32e-01	0.46300	-0.129000	4.45e-01	6.17e-01	8.51e-02
Cross-presentation of particulate exogenous antigens (phagosomes)	8	1.76e-01	3.02e-01	0.46200	0.360000	-2.90e-01	7.76e-02	1.56e-01
COPI-independent Golgi-to-ER retrograde traffic	45	4.46e-05	3.99e-04	0.46200	0.271000	-3.75e-01	1.69e-03	1.36e-05
Activated NTRK2 signals through FRS2 and FRS3	8	1.84e-01	3.10e-01	0.46200	0.328000	-3.26e-01	1.08e-01	1.11e-01
O-linked glycosylation of mucins	46	3.85e-05	3.46e-04	0.46000	0.374000	-2.69e-01	1.15e-05	1.63e-03
Olfactory Signaling Pathway	54	6.61e-09	1.25e-07	0.46000	0.452000	-8.69e-02	9.23e-09	2.70e-01
Biotin transport and metabolism	11	3.87e-02	1.03e-01	0.46000	-0.435000	1.49e-01	1.24e-02	3.94e-01
Crosslinking of collagen fibrils	12	5.67e-03	2.31e-02	0.45900	0.000698	4.59e-01	9.97e-01	5.86e-03
Processing and activation of SUMO	10	1.57e-03	8.41e-03	0.45900	-0.361000	-2.84e-01	4.80e-02	1.20e-01
Degradation of cysteine and homocysteine	12	8.19e-02	1.76e-01	0.45800	-0.335000	3.12e-01	4.42e-02	6.09e-02
DNA methylation	18	2.21e-02	6.76e-02	0.45700	0.287000	-3.56e-01	3.49e-02	8.97e-03
Transcription of E2F targets under negative control by DREAM complex	19	4.73e-03	2.04e-02	0.45700	0.160000	-4.28e-01	2.28e-01	1.24e-03
Interferon alpha/beta signaling	63	1.28e-15	5.24e-14	0.45700	-0.130000	-4.38e-01	7.37e-02	1.87e-09
Formation of the beta-catenin:TCF transactivating complex	44	9.69e-05	7.73e-04	0.45600	0.353000	-2.90e-01	5.15e-05	8.90e-04
Expression and translocation of olfactory receptors	49	6.19e-08	1.05e-06	0.45600	0.447000	-9.02e-02	6.23e-08	2.75e-01
Keratan sulfate biosynthesis	19	2.00e-02	6.29e-02	0.45500	0.337000	-3.06e-01	1.10e-02	2.09e-02
Diseases of branched-chain amino acid catabolism	13	1.64e-03	8.74e-03	0.45500	-0.449000	-7.56e-02	5.10e-03	6.37e-01
AKT phosphorylates targets in the nucleus	9	5.12e-02	1.25e-01	0.45500	-0.098600	4.44e-01	6.08e-01	2.10e-02
Uptake and function of anthrax toxins	10	1.27e-01	2.43e-01	0.45500	0.339000	-3.04e-01	6.37e-02	9.62e-02
Serine biosynthesis	8	1.94e-01	3.21e-01	0.45500	0.325000	-3.18e-01	1.12e-01	1.19e-01
FCGR3A-mediated IL10 synthesis	99	4.18e-11	1.02e-09	0.45500	0.213000	-4.02e-01	2.53e-04	4.76e-12
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	7	2.41e-02	7.14e-02	0.45500	0.120000	4.38e-01	5.81e-01	4.46e-02
Defective GALNT12 causes CRCS1	8	7.29e-02	1.62e-01	0.45400	0.443000	-1.01e-01	3.00e-02	6.21e-01
Gap junction assembly	16	2.55e-02	7.49e-02	0.45300	0.389000	-2.31e-01	7.00e-03	1.10e-01
MECP2 regulates neuronal receptors and channels	13	5.85e-02	1.38e-01	0.45100	0.250000	-3.76e-01	1.19e-01	1.89e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	6	2.96e-01	4.27e-01	0.45000	-0.342000	2.93e-01	1.47e-01	2.14e-01
Regulation of CDH11 mRNA translation by microRNAs	8	1.45e-01	2.66e-01	0.44800	0.200000	-4.01e-01	3.27e-01	4.94e-02
Regulation of NPAS4 mRNA translation	8	1.45e-01	2.66e-01	0.44800	0.200000	-4.01e-01	3.27e-01	4.94e-02
Cargo concentration in the ER	31	1.66e-03	8.79e-03	0.44800	0.270000	-3.57e-01	9.15e-03	5.73e-04
MET activates RAP1 and RAC1	10	1.38e-01	2.57e-01	0.44700	0.308000	-3.24e-01	9.14e-02	7.61e-02
Frs2-mediated activation	11	1.11e-01	2.19e-01	0.44600	0.291000	-3.39e-01	9.49e-02	5.18e-02
MAPK1 (ERK2) activation	8	1.62e-01	2.86e-01	0.44600	0.219000	-3.89e-01	2.83e-01	5.70e-02
Erythrocytes take up carbon dioxide and release oxygen	11	6.86e-02	1.56e-01	0.44600	0.403000	-1.92e-01	2.07e-02	2.70e-01
O2/CO2 exchange in erythrocytes	11	6.86e-02	1.56e-01	0.44600	0.403000	-1.92e-01	2.07e-02	2.70e-01
RHO GTPases activate PAKs	20	1.95e-02	6.18e-02	0.44600	0.305000	-3.25e-01	1.83e-02	1.18e-02
Anti-inflammatory response favouring Leishmania parasite infection	131	8.40e-13	2.37e-11	0.44500	0.245000	-3.72e-01	1.27e-06	1.93e-13
Leishmania parasite growth and survival	131	8.40e-13	2.37e-11	0.44500	0.245000	-3.72e-01	1.27e-06	1.93e-13
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	7	2.45e-01	3.72e-01	0.44500	0.347000	-2.80e-01	1.12e-01	2.00e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.10e-01	2.18e-01	0.44500	0.345000	-2.81e-01	4.74e-02	1.07e-01
Regulation of HMOX1 expression and activity	5	4.82e-02	1.20e-01	0.44500	0.346000	2.79e-01	1.80e-01	2.80e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	8.19e-05	6.64e-04	0.44400	0.298000	-3.30e-01	3.58e-04	7.78e-05
NADE modulates death signalling	5	1.70e-01	2.95e-01	0.44300	0.050500	-4.41e-01	8.45e-01	8.80e-02
EPHB-mediated forward signaling	38	1.83e-04	1.32e-03	0.44200	0.211000	-3.89e-01	2.43e-02	3.37e-05
Gain-of-function MRAS complexes activate RAF signaling	8	2.03e-01	3.30e-01	0.44200	0.272000	-3.48e-01	1.83e-01	8.79e-02
SHOC2 M1731 mutant abolishes MRAS complex function	8	2.03e-01	3.30e-01	0.44200	0.272000	-3.48e-01	1.83e-01	8.79e-02
Signaling by MRAS-complex mutants	8	2.03e-01	3.30e-01	0.44200	0.272000	-3.48e-01	1.83e-01	8.79e-02
Elevation of cytosolic Ca2+ levels	13	7.79e-02	1.70e-01	0.44100	0.341000	-2.80e-01	3.35e-02	8.04e-02
G beta:gamma signalling through BTK	15	4.35e-02	1.12e-01	0.44000	0.240000	-3.69e-01	1.07e-01	1.34e-02
Fcgamma receptor (FCGR) dependent phagocytosis	147	1.87e-14	6.19e-13	0.44000	0.225000	-3.78e-01	2.43e-06	2.45e-15
Signaling by Erythropoietin	24	7.88e-03	3.06e-02	0.44000	0.357000	-2.56e-01	2.45e-03	2.98e-02
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	5.80e-02	1.37e-01	0.43900	0.397000	-1.87e-01	1.72e-02	2.62e-01
Transport of connexons to the plasma membrane	12	5.80e-02	1.37e-01	0.43900	0.397000	-1.87e-01	1.72e-02	2.62e-01
SOS-mediated signalling	7	6.89e-02	1.56e-01	0.43900	0.439000	-1.18e-02	4.44e-02	9.57e-01
Interleukin receptor SHC signaling	23	1.26e-02	4.46e-02	0.43800	0.306000	-3.14e-01	1.11e-02	9.07e-03
Cyclin A/B1/B2 associated events during G2/M transition	25	4.15e-03	1.85e-02	0.43800	0.214000	-3.82e-01	6.40e-02	9.42e-04
Anchoring fibril formation	7	1.61e-02	5.32e-02	0.43700	0.327000	2.90e-01	1.34e-01	1.83e-01
Integration of provirus	9	1.30e-02	4.57e-02	0.43600	-0.423000	-1.06e-01	2.80e-02	5.81e-01
Translesion synthesis by POLI	17	1.70e-03	8.99e-03	0.43600	-0.436000	1.41e-02	1.86e-03	9.20e-01
Phosphate bond hydrolysis by NUDT proteins	7	7.33e-02	1.63e-01	0.43600	-0.435000	1.52e-02	4.60e-02	9.44e-01
ADP signalling through P2Y purinoceptor 12	18	2.35e-02	7.03e-02	0.43600	0.230000	-3.70e-01	9.14e-02	6.57e-03
RAS signaling downstream of NF1 loss-of-function variants	7	2.69e-01	3.97e-01	0.43500	0.301000	-3.14e-01	1.68e-01	1.50e-01
Presynaptic depolarization and calcium channel opening	8	2.04e-01	3.31e-01	0.43500	-0.250000	3.56e-01	2.21e-01	8.14e-02
Signaling by MAPK mutants	6	1.97e-01	3.24e-01	0.43500	-0.132000	4.14e-01	5.77e-01	7.89e-02
Regulation of PTEN localization	9	9.54e-02	1.96e-01	0.43300	0.142000	-4.09e-01	4.61e-01	3.34e-02
Classical antibody-mediated complement activation	69	2.65e-07	3.94e-06	0.43300	0.203000	-3.83e-01	3.61e-03	3.74e-08
DARPP-32 events	22	1.36e-02	4.73e-02	0.43300	0.255000	-3.50e-01	3.86e-02	4.45e-03
Interleukin-10 signaling	36	6.61e-09	1.25e-07	0.43300	0.399000	1.69e-01	3.48e-05	7.98e-02
Defective LFNG causes SCDO3	5	3.58e-01	4.90e-01	0.43300	0.367000	-2.29e-01	1.55e-01	3.76e-01
Initiation of Nuclear Envelope (NE) Reformation	19	2.03e-02	6.33e-02	0.43000	0.223000	-3.68e-01	9.23e-02	5.49e-03
FCERI mediated MAPK activation	93	2.86e-09	5.73e-08	0.42900	0.207000	-3.76e-01	5.44e-04	3.69e-10
Dectin-2 family	18	3.69e-02	9.95e-02	0.42900	0.287000	-3.19e-01	3.48e-02	1.92e-02
Purine ribonucleoside monophosphate biosynthesis	9	8.05e-02	1.75e-01	0.42900	-0.415000	1.10e-01	3.12e-02	5.69e-01
Kinesins	51	6.29e-05	5.23e-04	0.42900	0.343000	-2.57e-01	2.20e-05	1.49e-03
RHO GTPases Activate ROCKs	18	3.65e-02	9.88e-02	0.42900	0.281000	-3.24e-01	3.91e-02	1.73e-02
Sulfur amino acid metabolism	22	1.61e-02	5.32e-02	0.42800	-0.340000	2.59e-01	5.77e-03	3.53e-02
Erythropoietin activates RAS	13	9.59e-02	1.97e-01	0.42700	0.305000	-2.98e-01	5.65e-02	6.28e-02
Digestion	5	2.32e-01	3.62e-01	0.42500	0.416000	-8.63e-02	1.07e-01	7.38e-01
Negative regulation of MET activity	18	3.55e-02	9.68e-02	0.42400	0.255000	-3.39e-01	6.13e-02	1.28e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	3.64e-04	2.40e-03	0.42300	0.272000	-3.24e-01	1.81e-03	1.96e-04
Regulation of KIT signaling	15	6.71e-02	1.53e-01	0.42200	0.266000	-3.27e-01	7.42e-02	2.81e-02
Signaling by Leptin	10	8.19e-02	1.76e-01	0.41900	0.399000	-1.29e-01	2.90e-02	4.79e-01
FBXW7 Mutants and NOTCH1 in Cancer	5	4.05e-01	5.28e-01	0.41800	0.248000	-3.36e-01	3.37e-01	1.93e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	5	4.05e-01	5.28e-01	0.41800	0.248000	-3.36e-01	3.37e-01	1.93e-01
Proton-coupled monocarboxylate transport	6	3.40e-01	4.72e-01	0.41800	0.334000	-2.51e-01	1.56e-01	2.88e-01
E2F-enabled inhibition of pre-replication complex formation	9	6.36e-02	1.47e-01	0.41700	0.055600	-4.13e-01	7.73e-01	3.19e-02
2-LTR circle formation	7	2.48e-02	7.33e-02	0.41600	-0.332000	-2.50e-01	1.28e-01	2.51e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	5.66e-03	2.31e-02	0.41600	0.401000	-1.12e-01	1.92e-03	3.86e-01
Cellular response to starvation	148	1.28e-15	5.24e-14	0.41600	-0.389000	1.47e-01	2.93e-16	2.08e-03
Glucuronidation	8	1.87e-01	3.13e-01	0.41600	0.182000	-3.74e-01	3.73e-01	6.71e-02
Interactions of Vpr with host cellular proteins	37	1.06e-03	5.91e-03	0.41600	-0.346000	2.30e-01	2.65e-04	1.56e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	9	5.98e-02	1.40e-01	0.41600	0.045400	-4.13e-01	8.14e-01	3.18e-02
EGFR downregulation	26	1.37e-03	7.45e-03	0.41600	0.399000	-1.18e-01	4.35e-04	2.98e-01
Maturation of hRSV A proteins	13	1.96e-02	6.20e-02	0.41600	0.057600	-4.12e-01	7.19e-01	1.02e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	32	3.59e-03	1.64e-02	0.41500	0.256000	-3.27e-01	1.22e-02	1.36e-03
Glycosphingolipid biosynthesis	16	5.15e-02	1.26e-01	0.41500	0.347000	-2.27e-01	1.62e-02	1.16e-01
Protein lipoylation	10	8.08e-03	3.12e-02	0.41400	-0.380000	-1.65e-01	3.76e-02	3.65e-01
Prostanoid ligand receptors	8	2.23e-01	3.53e-01	0.41400	0.350000	-2.21e-01	8.62e-02	2.79e-01
Growth hormone receptor signaling	20	2.94e-02	8.41e-02	0.41400	0.330000	-2.49e-01	1.05e-02	5.40e-02
RHO GTPases activate CIT	18	4.12e-02	1.07e-01	0.41300	0.245000	-3.33e-01	7.21e-02	1.45e-02
Role of phospholipids in phagocytosis	88	9.89e-09	1.81e-07	0.41300	0.176000	-3.74e-01	4.34e-03	1.33e-09
Telomere C-strand synthesis initiation	13	1.43e-02	4.88e-02	0.41300	-0.412000	2.41e-02	1.01e-02	8.80e-01
Mitochondrial calcium ion transport	22	4.08e-03	1.84e-02	0.41300	-0.396000	1.17e-01	1.31e-03	3.43e-01
MAPK3 (ERK1) activation	9	2.03e-01	3.31e-01	0.41100	0.238000	-3.35e-01	2.16e-01	8.20e-02
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	7.53e-02	1.66e-01	0.41000	-0.133000	3.88e-01	4.45e-01	2.58e-02
Formation of Fibrin Clot (Clotting Cascade)	26	1.27e-02	4.49e-02	0.41000	0.272000	-3.07e-01	1.63e-02	6.68e-03
Gamma-carboxylation of protein precursors	6	3.53e-01	4.88e-01	0.41000	0.246000	-3.28e-01	2.96e-01	1.64e-01
FCERI mediated NF-kB activation	129	7.32e-13	2.13e-11	0.41000	0.158000	-3.79e-01	1.93e-03	1.10e-13
Fatty acids	6	2.13e-01	3.41e-01	0.41000	0.397000	-1.02e-01	9.22e-02	6.65e-01
Regulation of ornithine decarboxylase (ODC)	38	4.54e-05	4.02e-04	0.41000	0.094500	-3.99e-01	3.14e-01	2.10e-05
Cytochrome c-mediated apoptotic response	13	2.48e-03	1.23e-02	0.41000	-0.148000	-3.82e-01	3.55e-01	1.71e-02
Signalling to ERKs	32	4.91e-03	2.10e-02	0.41000	0.296000	-2.83e-01	3.70e-03	5.64e-03
Downregulation of ERBB2:ERBB3 signaling	12	1.17e-01	2.27e-01	0.40900	-0.340000	2.27e-01	4.13e-02	1.73e-01
Binding and Uptake of Ligands by Scavenger Receptors	90	1.42e-07	2.21e-06	0.40800	0.234000	-3.35e-01	1.25e-04	4.02e-08
VxPx cargo-targeting to cilium	19	4.17e-02	1.08e-01	0.40800	0.261000	-3.13e-01	4.93e-02	1.80e-02
Golgi-to-ER retrograde transport	123	4.43e-10	9.56e-09	0.40700	0.230000	-3.36e-01	1.02e-05	1.22e-10
RNA Polymerase III Chain Elongation	18	1.39e-02	4.80e-02	0.40600	-0.387000	1.21e-01	4.44e-03	3.74e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	2.04e-02	6.35e-02	0.40600	0.021200	4.05e-01	9.03e-01	1.99e-02
Defective CFTR causes cystic fibrosis	47	3.60e-06	4.32e-05	0.40600	0.082100	-3.97e-01	3.30e-01	2.45e-06
Synthesis of 15-eicosatetraenoic acid derivatives	6	3.68e-01	4.99e-01	0.40500	-0.253000	3.16e-01	2.83e-01	1.80e-01
SHC-related events triggered by IGF1R	7	3.16e-01	4.50e-01	0.40500	0.308000	-2.63e-01	1.58e-01	2.29e-01
Attachment and Entry 9694614	13	8.48e-02	1.81e-01	0.40500	0.356000	-1.93e-01	2.64e-02	2.28e-01
Translesion synthesis by REV1	16	3.65e-03	1.67e-02	0.40500	-0.404000	-1.99e-02	5.12e-03	8.90e-01
ADP signalling through P2Y purinoceptor 1	21	3.21e-02	9.03e-02	0.40400	0.308000	-2.62e-01	1.46e-02	3.77e-02
Downstream signal transduction	27	1.31e-02	4.59e-02	0.40300	0.287000	-2.83e-01	9.85e-03	1.09e-02
Chromatin modifications during the maternal to zygotic transition (MZT)	23	2.49e-02	7.34e-02	0.40300	0.287000	-2.82e-01	1.71e-02	1.91e-02
CREB3 factors activate genes	6	2.44e-01	3.71e-01	0.40200	-0.385000	1.18e-01	1.03e-01	6.18e-01
Regulation of expression of SLITs and ROBOs	149	1.69e-19	8.56e-18	0.40200	-0.400000	4.60e-02	3.60e-17	3.33e-01
Arachidonate production from DAG	5	4.09e-01	5.33e-01	0.40200	-0.343000	2.09e-01	1.84e-01	4.19e-01
Early Phase of HIV Life Cycle	14	2.25e-02	6.83e-02	0.40100	-0.395000	6.89e-02	1.05e-02	6.55e-01
Glucagon signaling in metabolic regulation	26	1.61e-02	5.32e-02	0.40000	0.277000	-2.89e-01	1.45e-02	1.07e-02
Hh mutants are degraded by ERAD	42	1.79e-05	1.83e-04	0.40000	0.080200	-3.92e-01	3.68e-01	1.10e-05
Resolution of Abasic Sites (AP sites)	38	2.32e-04	1.63e-03	0.40000	-0.377000	1.33e-01	5.79e-05	1.55e-01
Pyrimidine catabolism	9	2.38e-01	3.68e-01	0.40000	0.264000	-3.00e-01	1.70e-01	1.19e-01
Mitochondrial Uncoupling	6	3.75e-01	5.03e-01	0.39900	-0.317000	2.43e-01	1.79e-01	3.03e-01
Cross-presentation of soluble exogenous antigens (endosomes)	35	3.27e-04	2.20e-03	0.39900	0.120000	-3.81e-01	2.21e-01	9.59e-05
Interleukin-15 signaling	14	1.08e-01	2.16e-01	0.39900	0.266000	-2.98e-01	8.49e-02	5.38e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.29e-03	1.14e-02	0.39900	0.386000	-9.97e-02	8.35e-04	3.88e-01
Insulin processing	19	4.00e-02	1.05e-01	0.39800	0.222000	-3.31e-01	9.44e-02	1.25e-02
Abacavir ADME	5	4.46e-01	5.64e-01	0.39800	0.313000	-2.46e-01	2.26e-01	3.40e-01
Activated NTRK2 signals through RAS	6	3.81e-01	5.07e-01	0.39800	0.249000	-3.11e-01	2.92e-01	1.88e-01
Activated NTRK3 signals through RAS	6	3.81e-01	5.07e-01	0.39800	0.249000	-3.11e-01	2.92e-01	1.88e-01
Signaling by the B Cell Receptor (BCR)	150	2.87e-13	8.49e-12	0.39600	0.169000	-3.59e-01	3.66e-04	3.21e-14
H139Hfs13* PPM1K causes a mild variant of MSUD	5	1.13e-01	2.21e-01	0.39600	-0.367000	-1.50e-01	1.55e-01	5.62e-01
Maple Syrup Urine Disease	5	1.13e-01	2.21e-01	0.39600	-0.367000	-1.50e-01	1.55e-01	5.62e-01
Creation of C4 and C2 activators	71	1.48e-06	1.90e-05	0.39600	0.175000	-3.55e-01	1.09e-02	2.22e-07
Signaling by EGFR	47	8.80e-05	7.10e-04	0.39500	0.363000	-1.57e-01	1.69e-05	6.24e-02
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5	1.95e-01	3.21e-01	0.39500	0.011800	3.94e-01	9.64e-01	1.27e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	39	2.68e-05	2.55e-04	0.39400	0.057100	-3.90e-01	5.37e-01	2.49e-05
p53-Independent DNA Damage Response	39	2.68e-05	2.55e-04	0.39400	0.057100	-3.90e-01	5.37e-01	2.49e-05
p53-Independent G1/S DNA damage checkpoint	39	2.68e-05	2.55e-04	0.39400	0.057100	-3.90e-01	5.37e-01	2.49e-05
Respiratory syncytial virus (RSV) genome replication, transcription and translation	16	1.58e-02	5.25e-02	0.39400	0.071100	-3.88e-01	6.23e-01	7.24e-03
ATF6 (ATF6-alpha) activates chaperone genes	10	2.10e-01	3.38e-01	0.39400	0.301000	-2.55e-01	9.97e-02	1.63e-01
Activation of RAS in B cells	5	4.58e-01	5.73e-01	0.39300	0.250000	-3.04e-01	3.34e-01	2.39e-01
Specification of primordial germ cells	6	5.74e-02	1.36e-01	0.39300	0.284000	2.71e-01	2.28e-01	2.50e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters	8	2.03e-01	3.30e-01	0.39100	0.362000	-1.47e-01	7.63e-02	4.72e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.91e-01	3.19e-01	0.39000	0.277000	-2.74e-01	1.11e-01	1.16e-01
Activation of G protein gated Potassium channels	18	6.53e-02	1.50e-01	0.39000	0.257000	-2.93e-01	5.86e-02	3.16e-02
G protein gated Potassium channels	18	6.53e-02	1.50e-01	0.39000	0.257000	-2.93e-01	5.86e-02	3.16e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	6.53e-02	1.50e-01	0.39000	0.257000	-2.93e-01	5.86e-02	3.16e-02
Apoptotic cleavage of cellular proteins	35	1.07e-03	5.96e-03	0.39000	0.151000	-3.59e-01	1.22e-01	2.37e-04
Zygotic genome activation (ZGA)	5	1.01e-01	2.05e-01	0.38900	0.223000	3.19e-01	3.89e-01	2.16e-01
Replacement of protamines by nucleosomes in the male pronucleus	12	1.60e-01	2.84e-01	0.38900	0.247000	-3.01e-01	1.39e-01	7.13e-02
Interleukin-37 signaling	19	5.27e-02	1.28e-01	0.38900	0.308000	-2.38e-01	2.01e-02	7.29e-02
SUMOylation of transcription factors	16	9.13e-02	1.91e-01	0.38900	-0.276000	2.74e-01	5.57e-02	5.80e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.64e-03	2.02e-02	0.38900	-0.361000	1.44e-01	1.16e-03	1.95e-01
Inactivation of CDC42 and RAC1	7	2.33e-01	3.63e-01	0.38800	0.366000	-1.29e-01	9.36e-02	5.55e-01
Cellular response to mitochondrial stress	9	1.55e-02	5.18e-02	0.38800	-0.255000	-2.92e-01	1.86e-01	1.29e-01
Signaling by CSF3 (G-CSF)	29	4.72e-03	2.04e-02	0.38700	0.165000	-3.51e-01	1.24e-01	1.08e-03
RUNX2 regulates genes involved in cell migration	6	2.55e-01	3.84e-01	0.38700	-0.099400	3.74e-01	6.73e-01	1.13e-01
ATF6 (ATF6-alpha) activates chaperones	12	1.60e-01	2.84e-01	0.38700	0.239000	-3.05e-01	1.52e-01	6.77e-02
PCNA-Dependent Long Patch Base Excision Repair	21	5.98e-03	2.42e-02	0.38700	-0.379000	7.70e-02	2.64e-03	5.41e-01
LTC4-CYSLTR mediated IL4 production	5	1.57e-01	2.82e-01	0.38600	-0.082700	-3.77e-01	7.49e-01	1.44e-01
Signaling by ALK	24	2.01e-02	6.33e-02	0.38600	0.327000	-2.06e-01	5.61e-03	8.07e-02
Recycling of bile acids and salts	8	2.41e-01	3.70e-01	0.38600	0.345000	-1.74e-01	9.15e-02	3.94e-01
Uptake and function of diphtheria toxin	6	3.33e-01	4.65e-01	0.38600	0.349000	-1.64e-01	1.38e-01	4.86e-01
Synthesis of 5-eicosatetraenoic acids	7	2.25e-01	3.55e-01	0.38500	-0.116000	3.67e-01	5.96e-01	9.28e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	7.77e-03	3.02e-02	0.38500	-0.384000	1.97e-02	6.11e-03	8.88e-01
Signal regulatory protein family interactions	13	1.48e-01	2.69e-01	0.38400	0.256000	-2.86e-01	1.10e-01	7.37e-02
Beta-catenin phosphorylation cascade	17	7.44e-02	1.65e-01	0.38400	0.227000	-3.09e-01	1.05e-01	2.72e-02
Regulation of innate immune responses to cytosolic DNA	14	4.71e-02	1.18e-01	0.38300	-0.368000	1.05e-01	1.70e-02	4.98e-01
Inwardly rectifying K+ channels	22	3.38e-02	9.32e-02	0.38300	0.313000	-2.21e-01	1.11e-02	7.31e-02
Somitogenesis	41	3.59e-04	2.38e-03	0.38300	0.141000	-3.56e-01	1.19e-01	7.98e-05
Signaling by SCF-KIT	40	3.09e-03	1.44e-02	0.38200	0.276000	-2.65e-01	2.56e-03	3.76e-03
PKA activation	15	7.23e-02	1.61e-01	0.38200	0.342000	-1.70e-01	2.19e-02	2.53e-01
N-glycan trimming and elongation in the cis-Golgi	5	1.28e-01	2.43e-01	0.38100	-0.157000	-3.47e-01	5.43e-01	1.79e-01
p38MAPK events	13	1.54e-01	2.77e-01	0.38100	0.274000	-2.65e-01	8.66e-02	9.87e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	41	2.16e-05	2.11e-04	0.38100	0.042400	-3.79e-01	6.38e-01	2.72e-05
Translesion synthesis by POLK	17	3.10e-03	1.44e-02	0.38100	-0.376000	-5.61e-02	7.21e-03	6.89e-01
Alpha-oxidation of phytanate	6	2.41e-01	3.70e-01	0.38000	-0.373000	7.41e-02	1.13e-01	7.53e-01
Translesion Synthesis by POLH	18	3.89e-03	1.76e-02	0.38000	-0.380000	-1.75e-02	5.30e-03	8.98e-01
Fc epsilon receptor (FCERI) signaling	179	4.58e-14	1.49e-12	0.38000	0.171000	-3.39e-01	8.05e-05	4.61e-15
Regulation of activated PAK-2p34 by proteasome mediated degradation	37	9.30e-05	7.44e-04	0.38000	0.054600	-3.76e-01	5.66e-01	7.59e-05
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	2.76e-03	1.33e-02	0.37900	-0.372000	7.39e-02	1.28e-03	5.23e-01
Smooth Muscle Contraction	34	7.92e-03	3.07e-02	0.37900	0.270000	-2.66e-01	6.43e-03	7.17e-03
Interleukin-4 and Interleukin-13 signaling	89	4.57e-08	7.84e-07	0.37900	0.353000	-1.39e-01	8.57e-09	2.35e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	4.79e-03	2.06e-02	0.37900	-0.353000	1.37e-01	1.22e-03	2.10e-01
NFE2L2 regulating ER-stress associated genes	5	1.09e-01	2.17e-01	0.37900	0.271000	2.65e-01	2.95e-01	3.05e-01
Vitamin C (ascorbate) metabolism	8	1.61e-01	2.84e-01	0.37800	0.369000	-8.16e-02	7.04e-02	6.90e-01
PDH complex synthesizes acetyl-CoA from PYR	5	1.30e-01	2.46e-01	0.37700	-0.167000	-3.38e-01	5.18e-01	1.90e-01
Heme degradation	10	3.05e-02	8.68e-02	0.37600	0.368000	7.79e-02	4.39e-02	6.70e-01
Regulation of MITF-M-dependent genes involved in apoptosis	16	7.45e-02	1.65e-01	0.37600	0.182000	-3.29e-01	2.06e-01	2.28e-02
COPI-dependent Golgi-to-ER retrograde traffic	90	2.47e-06	3.06e-05	0.37600	0.232000	-2.96e-01	1.43e-04	1.25e-06
Degradation of GLI2 by the proteasome	45	3.46e-05	3.18e-04	0.37500	0.076200	-3.68e-01	3.76e-01	1.98e-05
GLI3 is processed to GLI3R by the proteasome	45	3.46e-05	3.18e-04	0.37500	0.076200	-3.68e-01	3.76e-01	1.98e-05
RNA Polymerase I Promoter Opening	17	7.75e-02	1.69e-01	0.37500	0.209000	-3.12e-01	1.36e-01	2.60e-02
Vif-mediated degradation of APOBEC3G	41	1.17e-05	1.23e-04	0.37500	0.012400	-3.75e-01	8.91e-01	3.27e-05
Signaling by cytosolic FGFR1 fusion mutants	18	6.99e-02	1.57e-01	0.37500	0.216000	-3.07e-01	1.13e-01	2.43e-02
tRNA processing in the nucleus	59	1.95e-05	1.95e-04	0.37500	-0.348000	1.40e-01	3.86e-06	6.22e-02
Repression of WNT target genes	14	1.08e-01	2.16e-01	0.37500	0.325000	-1.87e-01	3.55e-02	2.25e-01
Activation of Matrix Metalloproteinases	20	2.18e-03	1.10e-02	0.37500	0.374000	2.55e-02	3.79e-03	8.44e-01
G beta:gamma signalling through CDC42	17	4.68e-02	1.18e-01	0.37400	0.146000	-3.45e-01	2.98e-01	1.39e-02
Malate-aspartate shuttle	8	1.05e-01	2.13e-01	0.37400	-0.374000	5.35e-03	6.69e-02	9.79e-01
Interleukin-7 signaling	21	3.18e-02	8.97e-02	0.37400	0.331000	-1.73e-01	8.64e-03	1.70e-01
Hedgehog ligand biogenesis	47	3.82e-05	3.44e-04	0.37300	0.088200	-3.62e-01	2.95e-01	1.71e-05
Vpr-mediated nuclear import of PICs	34	5.61e-03	2.30e-02	0.37300	-0.317000	1.97e-01	1.40e-03	4.65e-02
PP2A-mediated dephosphorylation of key metabolic factors	7	3.11e-01	4.46e-01	0.37300	0.167000	-3.33e-01	4.45e-01	1.27e-01
Pexophagy	10	8.09e-02	1.75e-01	0.37300	-0.370000	4.08e-02	4.25e-02	8.23e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	74	3.96e-06	4.73e-05	0.37200	0.335000	-1.63e-01	6.20e-07	1.55e-02
Estrogen biosynthesis	5	4.02e-01	5.26e-01	0.37200	0.345000	-1.38e-01	1.81e-01	5.93e-01
APC truncation mutants have impaired AXIN binding	14	1.06e-01	2.13e-01	0.37200	0.178000	-3.27e-01	2.49e-01	3.44e-02
AXIN missense mutants destabilize the destruction complex	14	1.06e-01	2.13e-01	0.37200	0.178000	-3.27e-01	2.49e-01	3.44e-02
Signaling by AMER1 mutants	14	1.06e-01	2.13e-01	0.37200	0.178000	-3.27e-01	2.49e-01	3.44e-02
Signaling by APC mutants	14	1.06e-01	2.13e-01	0.37200	0.178000	-3.27e-01	2.49e-01	3.44e-02
Signaling by AXIN mutants	14	1.06e-01	2.13e-01	0.37200	0.178000	-3.27e-01	2.49e-01	3.44e-02
Truncations of AMER1 destabilize the destruction complex	14	1.06e-01	2.13e-01	0.37200	0.178000	-3.27e-01	2.49e-01	3.44e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	59	7.65e-05	6.28e-04	0.37200	0.176000	-3.28e-01	1.95e-02	1.35e-05
FLT3 signaling in disease	27	2.49e-02	7.34e-02	0.37200	0.267000	-2.59e-01	1.64e-02	1.99e-02
Gap junction trafficking	27	1.71e-02	5.55e-02	0.37100	0.315000	-1.97e-01	4.67e-03	7.59e-02
Regulation of signaling by CBL	22	4.02e-02	1.06e-01	0.37000	0.207000	-3.07e-01	9.27e-02	1.27e-02
Hh mutants abrogate ligand secretion	43	5.54e-05	4.66e-04	0.37000	0.066900	-3.64e-01	4.48e-01	3.62e-05
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	20	6.64e-02	1.52e-01	0.36900	0.248000	-2.73e-01	5.47e-02	3.43e-02
Regulation of Apoptosis	40	4.82e-05	4.21e-04	0.36900	0.037800	-3.67e-01	6.80e-01	5.86e-05
mRNA Editing	8	3.24e-01	4.57e-01	0.36900	0.296000	-2.20e-01	1.47e-01	2.82e-01
Protein methylation	15	4.70e-02	1.18e-01	0.36900	-0.355000	9.82e-02	1.72e-02	5.10e-01
p75NTR negatively regulates cell cycle via SC1	5	3.98e-01	5.21e-01	0.36800	0.127000	-3.46e-01	6.22e-01	1.81e-01
Miscellaneous substrates	7	5.68e-02	1.36e-01	0.36800	0.303000	2.09e-01	1.65e-01	3.38e-01
Tie2 Signaling	16	9.44e-02	1.95e-01	0.36800	0.198000	-3.11e-01	1.71e-01	3.15e-02
Metabolism of non-coding RNA	53	1.38e-04	1.05e-03	0.36800	-0.334000	1.55e-01	2.58e-05	5.16e-02
snRNP Assembly	53	1.38e-04	1.05e-03	0.36800	-0.334000	1.55e-01	2.58e-05	5.16e-02
Long-term potentiation	14	1.53e-01	2.77e-01	0.36800	-0.257000	2.63e-01	9.59e-02	8.82e-02
Maturation of spike protein 9694548	35	6.51e-03	2.61e-02	0.36800	0.206000	-3.05e-01	3.49e-02	1.82e-03
Regulation of RAS by GAPs	55	2.45e-05	2.37e-04	0.36800	0.112000	-3.50e-01	1.52e-01	7.05e-06
Signalling to RAS	19	7.61e-02	1.67e-01	0.36700	0.281000	-2.37e-01	3.39e-02	7.43e-02
Negative regulation of NOTCH4 signaling	44	2.89e-05	2.72e-04	0.36700	0.048800	-3.64e-01	5.75e-01	2.93e-05
cGMP effects	12	2.30e-02	6.91e-02	0.36700	0.051600	3.64e-01	7.57e-01	2.92e-02
Telomere C-strand (Lagging Strand) Synthesis	34	1.86e-04	1.35e-03	0.36700	-0.366000	2.88e-02	2.21e-04	7.71e-01
Phase 3 - rapid repolarisation	7	2.16e-01	3.43e-01	0.36600	0.072800	-3.59e-01	7.39e-01	9.99e-02
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	6	4.51e-01	5.66e-01	0.36600	0.256000	-2.62e-01	2.77e-01	2.67e-01
Cation-coupled Chloride cotransporters	6	1.56e-01	2.80e-01	0.36600	0.363000	4.71e-02	1.23e-01	8.42e-01
STAT5 Activation	7	2.30e-01	3.60e-01	0.36600	0.356000	-8.46e-02	1.03e-01	6.98e-01
Nef and signal transduction	8	2.45e-01	3.72e-01	0.36600	0.136000	-3.40e-01	5.05e-01	9.63e-02
Alternative complement activation	5	3.16e-01	4.50e-01	0.36600	-0.362000	5.60e-02	1.62e-01	8.28e-01
PECAM1 interactions	12	1.59e-01	2.84e-01	0.36600	0.179000	-3.19e-01	2.84e-01	5.56e-02
BBSome-mediated cargo-targeting to cilium	23	3.12e-04	2.12e-03	0.36600	-0.350000	-1.07e-01	3.69e-03	3.76e-01
RHOC GTPase cycle	71	5.35e-05	4.53e-04	0.36500	0.296000	-2.13e-01	1.61e-05	1.89e-03
Cell surface interactions at the vascular wall	170	4.29e-11	1.03e-09	0.36500	0.205000	-3.01e-01	3.95e-06	1.17e-11
Erythropoietin activates Phospholipase C gamma (PLCG)	6	4.05e-01	5.28e-01	0.36400	0.316000	-1.81e-01	1.80e-01	4.43e-01
Free fatty acids regulate insulin secretion	10	5.99e-02	1.40e-01	0.36400	0.364000	1.49e-02	4.65e-02	9.35e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	42	6.45e-05	5.34e-04	0.36400	0.052700	-3.60e-01	5.55e-01	5.44e-05
Other semaphorin interactions	16	6.00e-02	1.41e-01	0.36300	0.339000	-1.31e-01	1.90e-02	3.63e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	52	1.65e-05	1.70e-04	0.36300	0.076400	-3.55e-01	3.40e-01	9.39e-06
Class I peroxisomal membrane protein import	20	1.52e-03	8.18e-03	0.36200	-0.354000	-7.62e-02	6.09e-03	5.55e-01
Uptake of dietary cobalamins into enterocytes	5	4.25e-01	5.47e-01	0.36200	0.137000	-3.35e-01	5.96e-01	1.94e-01
Transport of nucleotide sugars	9	3.05e-01	4.40e-01	0.36200	-0.277000	2.33e-01	1.50e-01	2.26e-01
MAPK6/MAPK4 signaling	69	5.13e-06	5.94e-05	0.36100	0.126000	-3.39e-01	7.06e-02	1.13e-06
mRNA Splicing - Minor Pathway	50	1.97e-05	1.96e-04	0.36100	-0.355000	6.61e-02	1.38e-05	4.19e-01
Constitutive Signaling by EGFRvIII	14	1.65e-01	2.87e-01	0.36100	0.253000	-2.57e-01	1.02e-01	9.54e-02
Signaling by EGFRvIII in Cancer	14	1.65e-01	2.87e-01	0.36100	0.253000	-2.57e-01	1.02e-01	9.54e-02
Sema3A PAK dependent Axon repulsion	15	1.45e-01	2.66e-01	0.36000	0.249000	-2.61e-01	9.54e-02	8.03e-02
ADORA2B mediated anti-inflammatory cytokines production	35	1.04e-02	3.84e-02	0.35900	0.227000	-2.79e-01	2.02e-02	4.31e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	2.02e-01	3.30e-01	0.35900	0.215000	-2.88e-01	1.97e-01	8.41e-02
HDMs demethylate histones	22	9.88e-03	3.73e-02	0.35900	0.352000	-7.21e-02	4.27e-03	5.58e-01
Polymerase switching on the C-strand of the telomere	26	2.95e-03	1.39e-02	0.35900	-0.355000	5.21e-02	1.71e-03	6.46e-01
Signal amplification	28	2.66e-02	7.74e-02	0.35900	0.275000	-2.30e-01	1.17e-02	3.49e-02
Ubiquinol biosynthesis	13	1.15e-01	2.24e-01	0.35900	-0.331000	1.38e-01	3.87e-02	3.90e-01
Transcriptional Regulation by NPAS4	27	2.07e-02	6.38e-02	0.35900	0.308000	-1.83e-01	5.55e-03	9.93e-02
Signaling by FGFR4 in disease	11	2.41e-01	3.70e-01	0.35900	0.275000	-2.31e-01	1.15e-01	1.86e-01
Gap junction trafficking and regulation	29	1.85e-02	5.90e-02	0.35800	0.299000	-1.98e-01	5.37e-03	6.50e-02
Constitutive Signaling by Overexpressed ERBB2	11	2.41e-01	3.70e-01	0.35800	0.227000	-2.77e-01	1.92e-01	1.12e-01
Mucopolysaccharidoses	11	1.60e-01	2.84e-01	0.35800	-0.136000	3.31e-01	4.34e-01	5.74e-02
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5	2.16e-01	3.43e-01	0.35800	0.352000	6.16e-02	1.72e-01	8.12e-01
Acyl chain remodelling of PG	11	2.43e-01	3.71e-01	0.35700	0.275000	-2.28e-01	1.14e-01	1.91e-01
Lagging Strand Synthesis	20	1.42e-02	4.87e-02	0.35700	-0.351000	6.36e-02	6.57e-03	6.22e-01
ABC transporter disorders	59	4.52e-05	4.02e-04	0.35600	0.127000	-3.33e-01	9.04e-02	9.81e-06
Post-translational protein phosphorylation	67	5.07e-05	4.37e-04	0.35600	0.314000	-1.67e-01	8.73e-06	1.83e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	1.00e-03	5.71e-03	0.35400	0.268000	-2.32e-01	5.82e-04	2.93e-03
Synthesis of PE	12	2.14e-01	3.41e-01	0.35400	-0.214000	2.82e-01	1.99e-01	9.13e-02
Intrinsic Pathway of Fibrin Clot Formation	15	1.35e-01	2.54e-01	0.35400	0.197000	-2.93e-01	1.86e-01	4.92e-02
CDC6 association with the ORC:origin complex	8	9.70e-02	1.99e-01	0.35300	-0.051500	-3.49e-01	8.01e-01	8.74e-02
Apoptotic execution phase	46	3.19e-04	2.16e-03	0.35300	0.112000	-3.34e-01	1.91e-01	8.65e-05
Transport to the Golgi and subsequent modification	170	1.07e-10	2.44e-09	0.35300	0.187000	-2.99e-01	2.47e-05	1.84e-11
Nucleotide biosynthesis	12	1.23e-01	2.37e-01	0.35200	-0.334000	1.12e-01	4.50e-02	5.02e-01
Ubiquitin-dependent degradation of Cyclin D	39	1.71e-04	1.26e-03	0.35200	0.041500	-3.50e-01	6.54e-01	1.56e-04
Activation of C3 and C5	7	2.38e-01	3.68e-01	0.35200	-0.066000	3.46e-01	7.62e-01	1.13e-01
Degradation of GLI1 by the proteasome	46	1.22e-04	9.48e-04	0.35200	0.078400	-3.43e-01	3.58e-01	5.67e-05
Formation of apoptosome	11	1.82e-02	5.83e-02	0.35200	-0.175000	-3.05e-01	3.16e-01	7.96e-02
Regulation of the apoptosome activity	11	1.82e-02	5.83e-02	0.35200	-0.175000	-3.05e-01	3.16e-01	7.96e-02
Nuclear events mediated by NFE2L2	81	5.22e-05	4.43e-04	0.35100	0.241000	-2.55e-01	1.73e-04	7.36e-05
KSRP (KHSRP) binds and destabilizes mRNA	17	1.16e-02	4.20e-02	0.35100	-0.350000	-1.60e-02	1.24e-02	9.09e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	1.88e-05	1.90e-04	0.35100	0.136000	-3.23e-01	5.01e-02	3.51e-06
Leishmania infection	210	5.37e-12	1.43e-10	0.35000	0.220000	-2.73e-01	4.14e-08	8.69e-12
Parasitic Infection Pathways	210	5.37e-12	1.43e-10	0.35000	0.220000	-2.73e-01	4.14e-08	8.69e-12
Complex I biogenesis	66	3.22e-07	4.69e-06	0.35000	-0.349000	3.17e-02	9.51e-07	6.56e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	2.02e-01	3.30e-01	0.34900	0.348000	2.45e-02	1.39e-01	9.17e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	6	2.02e-01	3.30e-01	0.34900	0.348000	2.45e-02	1.39e-01	9.17e-01
Glutathione synthesis and recycling	10	2.68e-01	3.96e-01	0.34900	0.190000	-2.93e-01	2.98e-01	1.09e-01
Reversible hydration of carbon dioxide	8	5.38e-02	1.30e-01	0.34900	0.191000	2.92e-01	3.49e-01	1.53e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation	6	3.10e-01	4.46e-01	0.34900	-0.074100	3.41e-01	7.53e-01	1.48e-01
RNA Polymerase III Transcription Termination	22	2.94e-02	8.41e-02	0.34900	-0.324000	1.29e-01	8.51e-03	2.96e-01
Platelet homeostasis	69	2.47e-04	1.71e-03	0.34900	0.256000	-2.36e-01	2.34e-04	6.83e-04
TICAM1, RIP1-mediated IKK complex recruitment	19	5.73e-02	1.36e-01	0.34800	0.145000	-3.16e-01	2.75e-01	1.70e-02
Nucleotide-like (purinergic) receptors	14	1.47e-01	2.68e-01	0.34700	0.171000	-3.02e-01	2.67e-01	5.06e-02
RHOBTB2 GTPase cycle	23	1.62e-02	5.32e-02	0.34700	0.093800	-3.34e-01	4.36e-01	5.59e-03
SCF-beta-TrCP mediated degradation of Emi1	42	1.42e-04	1.07e-03	0.34700	0.046800	-3.43e-01	6.00e-01	1.18e-04
Biosynthesis of E-series 18(S)-resolvins	5	3.38e-01	4.70e-01	0.34600	0.344000	-3.78e-02	1.83e-01	8.84e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	64	1.31e-06	1.74e-05	0.34600	0.044800	-3.43e-01	5.35e-01	2.04e-06
Defective binding of VWF variant to GPIb:IX:V	5	4.48e-01	5.64e-01	0.34500	0.323000	-1.21e-01	2.11e-01	6.38e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen	5	4.48e-01	5.64e-01	0.34500	0.323000	-1.21e-01	2.11e-01	6.38e-01
Degradation of beta-catenin by the destruction complex	72	1.56e-05	1.62e-04	0.34500	0.133000	-3.19e-01	5.11e-02	2.94e-06
COPI-mediated anterograde transport	92	5.26e-06	6.01e-05	0.34500	0.177000	-2.96e-01	3.26e-03	9.25e-07
Autodegradation of the E3 ubiquitin ligase COP1	38	1.94e-04	1.39e-03	0.34500	0.023900	-3.44e-01	7.99e-01	2.43e-04
SARS-CoV-2 modulates autophagy	11	2.55e-01	3.84e-01	0.34500	-0.281000	2.00e-01	1.07e-01	2.51e-01
Adenylate cyclase activating pathway	8	5.48e-02	1.32e-01	0.34400	0.216000	2.67e-01	2.89e-01	1.90e-01
Biosynthesis of EPA-derived SPMs	6	2.11e-01	3.38e-01	0.34300	0.342000	2.70e-02	1.47e-01	9.09e-01
P2Y receptors	10	2.39e-01	3.68e-01	0.34200	0.147000	-3.09e-01	4.19e-01	9.08e-02
IkBA variant leads to EDA-ID	7	9.22e-02	1.92e-01	0.34200	0.161000	3.02e-01	4.61e-01	1.67e-01
Pre-NOTCH Processing in Golgi	18	1.09e-01	2.17e-01	0.34200	0.281000	-1.95e-01	3.93e-02	1.51e-01
RHOBTB GTPase Cycle	35	5.79e-03	2.35e-02	0.34200	0.139000	-3.12e-01	1.56e-01	1.38e-03
ER to Golgi Anterograde Transport	145	9.66e-09	1.79e-07	0.34100	0.180000	-2.90e-01	1.80e-04	1.65e-09
SCF(Skp2)-mediated degradation of p27/p21	50	2.06e-04	1.46e-03	0.34100	0.098500	-3.27e-01	2.28e-01	6.38e-05
Respiratory electron transport	149	6.56e-14	2.07e-12	0.34100	-0.338000	4.60e-02	1.03e-12	3.33e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	63	1.67e-06	2.13e-05	0.34100	0.036100	-3.39e-01	6.20e-01	3.22e-06
Collagen degradation	41	8.32e-04	4.83e-03	0.34100	0.328000	-9.21e-02	2.80e-04	3.07e-01
Laminin interactions	25	1.24e-02	4.41e-02	0.34000	0.329000	-8.70e-02	4.44e-03	4.51e-01
Orc1 removal from chromatin	58	2.49e-06	3.07e-05	0.34000	0.018000	-3.39e-01	8.13e-01	7.74e-06
NOTCH2 intracellular domain regulates transcription	11	2.88e-02	8.28e-02	0.34000	0.313000	1.33e-01	7.27e-02	4.46e-01
HS-GAG degradation	18	7.75e-02	1.69e-01	0.33900	-0.144000	3.07e-01	2.91e-01	2.39e-02
IRAK4 deficiency (TLR2/4)	15	1.12e-01	2.20e-01	0.33900	0.137000	-3.11e-01	3.60e-01	3.73e-02
MyD88 deficiency (TLR2/4)	14	1.54e-01	2.77e-01	0.33900	0.161000	-2.99e-01	2.98e-01	5.30e-02
Factors involved in megakaryocyte development and platelet production	128	2.25e-07	3.40e-06	0.33900	0.276000	-1.97e-01	7.11e-08	1.18e-04
tRNA processing	128	3.85e-08	6.67e-07	0.33800	-0.299000	1.59e-01	5.15e-09	1.93e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	1.93e-01	3.20e-01	0.33800	0.289000	-1.75e-01	7.15e-02	2.75e-01
Maturation of TCA enzymes and regulation of TCA cycle	20	9.31e-03	3.54e-02	0.33800	-0.338000	-2.11e-03	8.96e-03	9.87e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	2.36e-01	3.67e-01	0.33700	-0.190000	2.78e-01	2.54e-01	9.57e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	2.59e-01	3.87e-01	0.33600	0.249000	-2.26e-01	1.35e-01	1.75e-01
alpha-linolenic acid (ALA) metabolism	12	2.59e-01	3.87e-01	0.33600	0.249000	-2.26e-01	1.35e-01	1.75e-01
Interleukin-2 family signaling	38	1.38e-02	4.75e-02	0.33600	0.223000	-2.52e-01	1.74e-02	7.19e-03
Neutrophil degranulation	456	1.54e-22	9.87e-21	0.33600	0.229000	-2.46e-01	4.36e-17	2.17e-19
RHO GTPases activate PKNs	46	4.61e-03	2.01e-02	0.33600	0.200000	-2.70e-01	1.89e-02	1.51e-03
L1CAM interactions	100	3.25e-06	3.95e-05	0.33600	0.290000	-1.70e-01	5.46e-07	3.28e-03
Vpu mediated degradation of CD4	39	1.30e-04	9.99e-04	0.33600	0.000853	-3.36e-01	9.93e-01	2.82e-04
Inactivation of CSF3 (G-CSF) signaling	24	1.75e-02	5.65e-02	0.33600	0.090100	-3.23e-01	4.45e-01	6.09e-03
Nuclear events stimulated by ALK signaling in cancer	33	1.55e-02	5.18e-02	0.33600	0.170000	-2.89e-01	9.09e-02	4.03e-03
Termination of translesion DNA synthesis	32	2.61e-04	1.79e-03	0.33500	-0.333000	-4.08e-02	1.12e-03	6.89e-01
Mitochondrial unfolded protein response (UPRmt)	17	5.75e-02	1.36e-01	0.33500	-0.090400	3.23e-01	5.19e-01	2.11e-02
Pentose phosphate pathway	13	1.75e-01	3.01e-01	0.33500	0.151000	-2.99e-01	3.45e-01	6.17e-02
VEGFA-VEGFR2 Pathway	93	3.41e-05	3.18e-04	0.33500	0.241000	-2.32e-01	5.76e-05	1.10e-04
Condensation of Prophase Chromosomes	27	3.32e-02	9.24e-02	0.33400	0.168000	-2.89e-01	1.31e-01	9.27e-03
Depolymerization of the Nuclear Lamina	15	1.79e-01	3.05e-01	0.33400	0.265000	-2.03e-01	7.52e-02	1.73e-01
Killing mechanisms	9	9.97e-02	2.03e-01	0.33400	0.040500	3.32e-01	8.33e-01	8.47e-02
WNT5:FZD7-mediated leishmania damping	9	9.97e-02	2.03e-01	0.33400	0.040500	3.32e-01	8.33e-01	8.47e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	14	2.08e-01	3.35e-01	0.33400	-0.216000	2.55e-01	1.62e-01	9.85e-02
SUMOylation of ubiquitinylation proteins	39	1.19e-02	4.31e-02	0.33400	-0.263000	2.05e-01	4.48e-03	2.64e-02
tRNA modification in the nucleus and cytosol	43	2.91e-03	1.38e-02	0.33200	-0.301000	1.41e-01	6.43e-04	1.09e-01
Modulation by Mtb of host immune system	7	1.76e-01	3.02e-01	0.33200	-0.331000	-3.29e-02	1.30e-01	8.80e-01
RHOBTB1 GTPase cycle	23	2.77e-02	8.00e-02	0.33200	0.104000	-3.15e-01	3.89e-01	8.87e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.20e-02	4.33e-02	0.33100	-0.324000	6.76e-02	5.09e-03	5.58e-01
RHO GTPase Effectors	257	7.51e-14	2.29e-12	0.33100	0.178000	-2.79e-01	8.96e-07	1.42e-14
Transport of Ribonucleoproteins into the Host Nucleus	32	1.94e-02	6.14e-02	0.33000	-0.286000	1.65e-01	5.09e-03	1.06e-01
NPAS4 regulates expression of target genes	16	2.01e-02	6.33e-02	0.33000	0.328000	3.27e-02	2.31e-02	8.21e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	9	1.09e-01	2.17e-01	0.32900	-0.036100	-3.27e-01	8.51e-01	8.90e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	50	4.22e-03	1.88e-02	0.32900	0.255000	-2.09e-01	1.83e-03	1.07e-02
PI3K events in ERBB4 signaling	6	1.60e-01	2.84e-01	0.32900	0.300000	1.34e-01	2.03e-01	5.69e-01
Late SARS-CoV-2 Infection Events	63	4.63e-04	2.90e-03	0.32900	0.164000	-2.85e-01	2.39e-02	9.30e-05
PI-3K cascade:FGFR3	10	3.31e-01	4.64e-01	0.32800	0.261000	-2.00e-01	1.54e-01	2.74e-01
Initial triggering of complement	79	3.55e-05	3.25e-04	0.32700	0.143000	-2.94e-01	2.75e-02	6.05e-06
CTNNB1 S33 mutants aren’t phosphorylated	15	1.81e-01	3.06e-01	0.32700	0.182000	-2.71e-01	2.22e-01	6.90e-02
CTNNB1 S37 mutants aren’t phosphorylated	15	1.81e-01	3.06e-01	0.32700	0.182000	-2.71e-01	2.22e-01	6.90e-02
CTNNB1 S45 mutants aren’t phosphorylated	15	1.81e-01	3.06e-01	0.32700	0.182000	-2.71e-01	2.22e-01	6.90e-02
CTNNB1 T41 mutants aren’t phosphorylated	15	1.81e-01	3.06e-01	0.32700	0.182000	-2.71e-01	2.22e-01	6.90e-02
Signaling by CTNNB1 phospho-site mutants	15	1.81e-01	3.06e-01	0.32700	0.182000	-2.71e-01	2.22e-01	6.90e-02
Signaling by GSK3beta mutants	15	1.81e-01	3.06e-01	0.32700	0.182000	-2.71e-01	2.22e-01	6.90e-02
Retinoid metabolism and transport	23	8.48e-03	3.26e-02	0.32700	0.326000	-1.46e-02	6.76e-03	9.03e-01
Response to elevated platelet cytosolic Ca2+	108	9.64e-06	1.05e-04	0.32600	0.207000	-2.52e-01	1.97e-04	6.12e-06
GPVI-mediated activation cascade	31	3.76e-02	1.01e-01	0.32600	0.218000	-2.43e-01	3.57e-02	1.94e-02
COPII-mediated vesicle transport	67	3.74e-04	2.45e-03	0.32600	0.168000	-2.79e-01	1.75e-02	7.71e-05
Phase 2 - plateau phase	12	2.63e-01	3.91e-01	0.32600	0.188000	-2.66e-01	2.60e-01	1.10e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	42	2.99e-04	2.04e-03	0.32600	0.033600	-3.24e-01	7.07e-01	2.81e-04
Mitochondrial Fatty Acid Beta-Oxidation	36	4.85e-04	3.00e-03	0.32500	-0.325000	5.07e-03	7.35e-04	9.58e-01
Activation of RAC1	11	1.58e-01	2.83e-01	0.32500	0.071400	-3.17e-01	6.82e-01	6.87e-02
Recycling of eIF2:GDP	8	1.48e-01	2.69e-01	0.32400	-0.322000	-3.63e-02	1.15e-01	8.59e-01
Insulin receptor recycling	24	6.14e-02	1.44e-01	0.32400	0.277000	-1.68e-01	1.88e-02	1.54e-01
Hydrolysis of LPC	8	1.54e-01	2.77e-01	0.32300	0.321000	3.14e-02	1.15e-01	8.78e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	1.72e-02	5.58e-02	0.32300	0.298000	1.24e-01	5.34e-02	4.22e-01
Mitochondrial protein degradation	96	4.76e-09	9.15e-08	0.32300	-0.322000	1.82e-02	4.79e-08	7.58e-01
Phase 0 - rapid depolarisation	23	6.26e-02	1.45e-01	0.32300	0.283000	-1.54e-01	1.86e-02	2.01e-01
HDL remodeling	6	1.51e-01	2.74e-01	0.32200	0.263000	1.86e-01	2.64e-01	4.29e-01
NS1 Mediated Effects on Host Pathways	40	3.38e-03	1.56e-02	0.32200	-0.303000	1.09e-01	9.03e-04	2.33e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	3.41e-02	9.38e-02	0.32200	-0.110000	-3.02e-01	5.08e-01	6.96e-02
Proteasome assembly	50	2.02e-06	2.53e-05	0.32200	-0.078100	-3.12e-01	3.39e-01	1.33e-04
Regulation of Complement cascade	96	3.61e-05	3.27e-04	0.32200	0.192000	-2.58e-01	1.14e-03	1.25e-05
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	1.89e-03	9.82e-03	0.32200	-0.008000	-3.22e-01	9.41e-01	2.73e-03
Chemokine receptors bind chemokines	39	1.20e-04	9.31e-04	0.32100	0.320000	3.15e-02	5.48e-04	7.33e-01
Drug-mediated inhibition of CDK4/CDK6 activity	5	5.49e-01	6.53e-01	0.32100	0.153000	-2.83e-01	5.55e-01	2.74e-01
Degradation of DVL	43	7.44e-04	4.36e-03	0.32100	0.064600	-3.15e-01	4.64e-01	3.57e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	61	6.40e-06	7.27e-05	0.32100	0.020300	-3.20e-01	7.84e-01	1.51e-05
Mitochondrial iron-sulfur cluster biogenesis	13	8.66e-02	1.84e-01	0.32100	-0.319000	3.23e-02	4.63e-02	8.40e-01
Plasma lipoprotein assembly	10	1.36e-01	2.54e-01	0.32000	0.320000	-1.45e-02	7.96e-02	9.37e-01
Scavenging by Class A Receptors	10	1.28e-01	2.43e-01	0.32000	0.320000	-5.85e-03	7.93e-02	9.74e-01
ROS and RNS production in phagocytes	30	4.81e-02	1.20e-01	0.32000	0.227000	-2.25e-01	3.12e-02	3.30e-02
Transport of the SLBP Dependant Mature mRNA	36	2.31e-02	6.92e-02	0.31900	-0.255000	1.91e-01	8.09e-03	4.72e-02
MET activates RAS signaling	10	3.63e-01	4.95e-01	0.31900	0.238000	-2.12e-01	1.93e-01	2.46e-01
Assembly of the ORC complex at the origin of replication	23	1.42e-02	4.87e-02	0.31800	0.032600	-3.17e-01	7.87e-01	8.56e-03
Detoxification of Reactive Oxygen Species	30	3.42e-02	9.39e-02	0.31800	0.164000	-2.73e-01	1.20e-01	9.75e-03
CD28 dependent Vav1 pathway	12	9.51e-02	1.96e-01	0.31800	0.014800	-3.17e-01	9.29e-01	5.69e-02
Ca2+ pathway	57	3.39e-03	1.56e-02	0.31800	0.229000	-2.20e-01	2.74e-03	4.10e-03
Interleukin-35 Signalling	12	2.54e-01	3.83e-01	0.31800	0.158000	-2.75e-01	3.42e-01	9.89e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	5.66e-02	1.36e-01	0.31700	-0.070300	3.09e-01	6.06e-01	2.31e-02
Signaling by ALK fusions and activated point mutants	89	1.39e-04	1.05e-03	0.31700	0.213000	-2.35e-01	5.25e-04	1.24e-04
Signaling by ALK in cancer	89	1.39e-04	1.05e-03	0.31700	0.213000	-2.35e-01	5.25e-04	1.24e-04
PINK1-PRKN Mediated Mitophagy	31	8.01e-05	6.52e-04	0.31700	-0.260000	-1.82e-01	1.24e-02	7.91e-02
Platelet degranulation	104	2.84e-05	2.69e-04	0.31700	0.201000	-2.44e-01	3.85e-04	1.69e-05
AMPK inhibits chREBP transcriptional activation activity	6	5.52e-01	6.55e-01	0.31600	-0.228000	2.20e-01	3.34e-01	3.52e-01
Cellular response to hypoxia	59	3.22e-04	2.17e-03	0.31600	0.108000	-2.97e-01	1.51e-01	7.84e-05
Vasopressin regulates renal water homeostasis via Aquaporins	34	3.48e-02	9.51e-02	0.31600	0.228000	-2.19e-01	2.14e-02	2.73e-02
Interleukin-2 signaling	11	3.32e-01	4.65e-01	0.31600	0.204000	-2.41e-01	2.41e-01	1.66e-01
Acyl chain remodelling of PC	19	1.48e-01	2.69e-01	0.31500	0.245000	-1.99e-01	6.44e-02	1.34e-01
Activation of gene expression by SREBF (SREBP)	42	1.05e-02	3.87e-02	0.31500	0.267000	-1.67e-01	2.75e-03	6.06e-02
RNA Polymerase I Transcription Termination	30	2.71e-02	7.84e-02	0.31500	-0.283000	1.38e-01	7.26e-03	1.90e-01
G-protein activation	19	1.54e-01	2.77e-01	0.31400	0.234000	-2.10e-01	7.77e-02	1.12e-01
PKA activation in glucagon signalling	14	2.28e-01	3.58e-01	0.31400	0.261000	-1.75e-01	9.09e-02	2.56e-01
Translation of Structural Proteins 9694635	55	1.03e-03	5.83e-03	0.31400	0.126000	-2.88e-01	1.06e-01	2.21e-04
Digestion and absorption	7	3.53e-01	4.88e-01	0.31400	0.303000	-8.24e-02	1.65e-01	7.06e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	60	7.64e-06	8.58e-05	0.31400	0.006580	-3.14e-01	9.30e-01	2.60e-05
Endosomal/Vacuolar pathway	11	1.23e-01	2.37e-01	0.31400	-0.313000	1.63e-02	7.18e-02	9.25e-01
Attenuation phase	22	7.00e-02	1.57e-01	0.31400	0.284000	-1.34e-01	2.12e-02	2.78e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	7	1.38e-01	2.57e-01	0.31400	0.281000	1.39e-01	1.98e-01	5.23e-01
GABA receptor activation	35	2.02e-02	6.33e-02	0.31300	0.272000	-1.55e-01	5.32e-03	1.12e-01
FGFR1 ligand binding and activation	10	3.77e-01	5.04e-01	0.31300	-0.211000	2.32e-01	2.48e-01	2.05e-01
RUNX3 regulates NOTCH signaling	14	1.57e-02	5.22e-02	0.31300	0.256000	1.80e-01	9.68e-02	2.44e-01
Aspirin ADME	13	1.45e-01	2.66e-01	0.31300	0.302000	-8.06e-02	5.92e-02	6.15e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	6.59e-04	3.93e-03	0.31300	0.137000	-2.81e-01	6.15e-02	1.30e-04
Protein localization	157	9.36e-13	2.61e-11	0.31200	-0.311000	3.31e-02	1.83e-11	4.74e-01
Metabolism of polyamines	46	3.37e-04	2.26e-03	0.31100	0.036500	-3.09e-01	6.68e-01	2.85e-04
Metabolism of Angiotensinogen to Angiotensins	12	3.04e-01	4.39e-01	0.31100	0.247000	-1.89e-01	1.39e-01	2.58e-01
E2F mediated regulation of DNA replication	22	5.39e-03	2.24e-02	0.31100	-0.064000	-3.04e-01	6.03e-01	1.36e-02
Organic cation transport	8	1.77e-01	3.02e-01	0.31000	0.308000	3.20e-02	1.31e-01	8.75e-01
Organic cation/anion/zwitterion transport	8	1.77e-01	3.02e-01	0.31000	0.308000	3.20e-02	1.31e-01	8.75e-01
RORA activates gene expression	18	8.42e-02	1.80e-01	0.31000	0.295000	-9.43e-02	3.01e-02	4.89e-01
Glycine degradation	7	5.05e-01	6.16e-01	0.31000	0.194000	-2.42e-01	3.75e-01	2.68e-01
Transport of the SLBP independent Mature mRNA	35	3.31e-02	9.23e-02	0.30900	-0.243000	1.92e-01	1.29e-02	4.96e-02
activated TAK1 mediates p38 MAPK activation	23	1.09e-01	2.17e-01	0.30900	0.238000	-1.98e-01	4.81e-02	1.01e-01
Fibronectin matrix formation	6	4.17e-01	5.39e-01	0.30900	0.299000	-7.85e-02	2.04e-01	7.39e-01
Sema4D mediated inhibition of cell attachment and migration	7	1.33e-01	2.52e-01	0.30900	0.174000	2.55e-01	4.26e-01	2.42e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.16e-01	3.42e-01	0.30900	-0.296000	8.81e-02	8.94e-02	6.13e-01
HS-GAG biosynthesis	19	1.65e-01	2.87e-01	0.30800	0.204000	-2.32e-01	1.24e-01	8.03e-02
Activation of the AP-1 family of transcription factors	10	3.65e-01	4.97e-01	0.30800	0.254000	-1.75e-01	1.64e-01	3.37e-01
Plasma lipoprotein remodeling	18	2.05e-02	6.35e-02	0.30800	0.306000	3.44e-02	2.44e-02	8.00e-01
Degradation of AXIN	42	4.77e-04	2.97e-03	0.30800	0.017000	-3.07e-01	8.49e-01	5.66e-04
RNA Polymerase I Transcription Initiation	47	7.15e-03	2.83e-02	0.30800	-0.264000	1.59e-01	1.76e-03	5.97e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	2.39e-01	3.68e-01	0.30800	-0.290000	1.03e-01	9.62e-02	5.54e-01
Resolution of Sister Chromatid Cohesion	115	2.82e-07	4.17e-06	0.30700	0.100000	-2.91e-01	6.37e-02	7.18e-08
Regulation of MECP2 expression and activity	28	3.92e-02	1.04e-01	0.30700	0.132000	-2.78e-01	2.26e-01	1.10e-02
Triglyceride metabolism	24	1.05e-01	2.12e-01	0.30700	0.229000	-2.05e-01	5.23e-02	8.20e-02
NF-kB is activated and signals survival	12	1.92e-01	3.19e-01	0.30700	-0.088900	2.94e-01	5.94e-01	7.79e-02
CLEC7A (Dectin-1) induces NFAT activation	11	2.46e-01	3.73e-01	0.30700	0.107000	-2.88e-01	5.39e-01	9.84e-02
Miro GTPase Cycle	8	4.48e-01	5.64e-01	0.30700	0.254000	-1.72e-01	2.13e-01	4.00e-01
Mitotic G1 phase and G1/S transition	138	3.06e-09	5.99e-08	0.30700	0.078800	-2.96e-01	1.10e-01	1.82e-09
RHOF GTPase cycle	38	2.35e-02	7.03e-02	0.30600	0.251000	-1.75e-01	7.41e-03	6.12e-02
Acyl chain remodelling of PI	10	3.92e-01	5.17e-01	0.30600	0.231000	-2.00e-01	2.05e-01	2.73e-01
STAT3 nuclear events downstream of ALK signaling	11	3.55e-01	4.88e-01	0.30600	0.235000	-1.96e-01	1.77e-01	2.61e-01
Pre-NOTCH Transcription and Translation	47	1.30e-02	4.57e-02	0.30500	0.225000	-2.06e-01	7.55e-03	1.45e-02
Glycogen synthesis	11	9.53e-02	1.96e-01	0.30500	-0.037500	-3.03e-01	8.30e-01	8.20e-02
Hemostasis	553	2.42e-22	1.45e-20	0.30500	0.218000	-2.14e-01	1.83e-18	8.59e-18
Apoptotic cleavage of cell adhesion proteins	8	3.96e-01	5.20e-01	0.30500	0.127000	-2.77e-01	5.34e-01	1.74e-01
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	85	4.00e-04	2.57e-03	0.30500	0.207000	-2.24e-01	9.93e-04	3.51e-04
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	85	4.00e-04	2.57e-03	0.30500	0.207000	-2.24e-01	9.93e-04	3.51e-04
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	85	4.00e-04	2.57e-03	0.30500	0.207000	-2.24e-01	9.93e-04	3.51e-04
Activation of GABAB receptors	29	5.31e-02	1.29e-01	0.30500	0.258000	-1.62e-01	1.63e-02	1.30e-01
GABA B receptor activation	29	5.31e-02	1.29e-01	0.30500	0.258000	-1.62e-01	1.63e-02	1.30e-01
RAB geranylgeranylation	62	8.41e-04	4.87e-03	0.30400	0.128000	-2.76e-01	8.07e-02	1.72e-04
The activation of arylsulfatases	10	3.34e-01	4.66e-01	0.30400	-0.271000	1.39e-01	1.38e-01	4.48e-01
Formation of ATP by chemiosmotic coupling	20	1.49e-02	5.06e-02	0.30400	-0.302000	-3.52e-02	1.96e-02	7.85e-01
Cyclin E associated events during G1/S transition	73	4.69e-05	4.12e-04	0.30400	0.083300	-2.92e-01	2.18e-01	1.61e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.46e-06	1.90e-05	0.30200	-0.302000	1.47e-02	5.27e-06	8.25e-01
PI-3K cascade:FGFR4	11	3.55e-01	4.89e-01	0.30200	0.241000	-1.83e-01	1.67e-01	2.94e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	191	1.64e-09	3.35e-08	0.30200	0.142000	-2.67e-01	7.29e-04	2.02e-10
Leading Strand Synthesis	14	1.90e-01	3.17e-01	0.30200	-0.279000	1.15e-01	7.04e-02	4.57e-01
Polymerase switching	14	1.90e-01	3.17e-01	0.30200	-0.279000	1.15e-01	7.04e-02	4.57e-01
Stabilization of p53	43	2.39e-04	1.67e-03	0.30200	-0.013500	-3.01e-01	8.78e-01	6.27e-04
Cardiac conduction	88	3.03e-04	2.07e-03	0.30200	0.236000	-1.88e-01	1.33e-04	2.28e-03
Signaling by VEGF	100	1.28e-04	9.90e-04	0.30100	0.214000	-2.13e-01	2.23e-04	2.37e-04
Prolactin receptor signaling	11	4.87e-02	1.21e-01	0.30100	-0.176000	-2.44e-01	3.13e-01	1.61e-01
Regulation of beta-cell development	21	9.89e-03	3.73e-02	0.30000	0.294000	5.88e-02	1.96e-02	6.41e-01
Prostacyclin signalling through prostacyclin receptor	16	1.69e-01	2.94e-01	0.30000	0.127000	-2.72e-01	3.79e-01	5.99e-02
p130Cas linkage to MAPK signaling for integrins	11	3.36e-01	4.69e-01	0.30000	0.157000	-2.55e-01	3.67e-01	1.43e-01
Downstream signaling events of B Cell Receptor (BCR)	68	1.60e-04	1.18e-03	0.29900	0.089400	-2.85e-01	2.03e-01	4.71e-05
RAB GEFs exchange GTP for GDP on RABs	89	3.51e-04	2.34e-03	0.29900	0.193000	-2.28e-01	1.61e-03	2.01e-04
Synthesis of PI	5	2.57e-01	3.85e-01	0.29900	0.178000	2.40e-01	4.90e-01	3.53e-01
Aquaporin-mediated transport	38	3.50e-02	9.54e-02	0.29900	0.216000	-2.06e-01	2.13e-02	2.76e-02
Vesicle-mediated transport	663	8.64e-28	1.04e-25	0.29900	0.161000	-2.51e-01	1.40e-12	2.38e-28
Neurofascin interactions	5	5.68e-01	6.67e-01	0.29800	0.274000	-1.19e-01	2.89e-01	6.46e-01
Signaling by KIT in disease	20	6.66e-02	1.52e-01	0.29800	0.075500	-2.88e-01	5.59e-01	2.56e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	6.66e-02	1.52e-01	0.29800	0.075500	-2.88e-01	5.59e-01	2.56e-02
Caspase-mediated cleavage of cytoskeletal proteins	12	1.64e-01	2.87e-01	0.29800	0.048800	-2.94e-01	7.70e-01	7.81e-02
Activation of NF-kappaB in B cells	54	1.09e-03	6.04e-03	0.29800	0.090700	-2.83e-01	2.49e-01	3.16e-04
Transcriptional Regulation by MECP2	47	1.51e-02	5.08e-02	0.29700	0.188000	-2.30e-01	2.57e-02	6.29e-03
DAP12 signaling	28	4.27e-02	1.11e-01	0.29700	0.118000	-2.73e-01	2.80e-01	1.24e-02
Incretin synthesis, secretion, and inactivation	14	1.65e-01	2.87e-01	0.29700	0.085900	-2.85e-01	5.78e-01	6.53e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	1.65e-01	2.87e-01	0.29700	0.085900	-2.85e-01	5.78e-01	6.53e-02
Regulation of insulin secretion	62	2.23e-03	1.11e-02	0.29700	0.256000	-1.51e-01	5.00e-04	3.94e-02
InlA-mediated entry of Listeria monocytogenes into host cells	9	3.23e-01	4.57e-01	0.29700	-0.282000	9.17e-02	1.42e-01	6.34e-01
Processive synthesis on the lagging strand	15	8.11e-02	1.75e-01	0.29700	-0.296000	1.98e-02	4.70e-02	8.94e-01
Export of Viral Ribonucleoproteins from Nucleus	33	4.80e-02	1.20e-01	0.29700	-0.241000	1.73e-01	1.65e-02	8.55e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	4.57e-02	1.16e-01	0.29700	0.280000	9.84e-02	8.05e-02	5.39e-01
Mitochondrial tRNA aminoacylation	21	5.02e-02	1.23e-01	0.29700	-0.290000	6.05e-02	2.12e-02	6.31e-01
Rev-mediated nuclear export of HIV RNA	35	3.77e-02	1.01e-01	0.29700	-0.246000	1.66e-01	1.19e-02	8.94e-02
Potential therapeutics for SARS	148	1.06e-07	1.72e-06	0.29600	0.124000	-2.69e-01	9.44e-03	1.55e-08
Cell-extracellular matrix interactions	15	2.41e-01	3.70e-01	0.29600	0.161000	-2.49e-01	2.80e-01	9.56e-02
NEP/NS2 Interacts with the Cellular Export Machinery	32	4.64e-02	1.17e-01	0.29600	-0.251000	1.56e-01	1.39e-02	1.27e-01
RHOG GTPase cycle	70	2.00e-03	1.03e-02	0.29500	0.233000	-1.82e-01	7.60e-04	8.53e-03
Nectin/Necl trans heterodimerization	5	5.31e-01	6.37e-01	0.29500	0.282000	-8.58e-02	2.74e-01	7.40e-01
eNOS activation	10	7.83e-02	1.70e-01	0.29500	-0.142000	-2.59e-01	4.37e-01	1.57e-01
TCF dependent signaling in response to WNT	151	1.23e-06	1.65e-05	0.29500	0.173000	-2.39e-01	2.40e-04	4.04e-07
Regulation of TP53 Activity through Methylation	19	1.27e-01	2.43e-01	0.29500	-0.268000	1.22e-01	4.29e-02	3.56e-01
Regulation of gene expression in beta cells	7	3.91e-01	5.17e-01	0.29500	0.286000	-7.17e-02	1.90e-01	7.43e-01
CLEC7A/inflammasome pathway	6	2.24e-01	3.54e-01	0.29500	0.130000	2.64e-01	5.82e-01	2.62e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	183	1.36e-09	2.83e-08	0.29400	0.113000	-2.72e-01	8.66e-03	2.20e-10
Activation of AMPK downstream of NMDARs	20	1.80e-01	3.05e-01	0.29400	0.215000	-2.01e-01	9.59e-02	1.20e-01
Evasion by RSV of host interferon responses	20	2.15e-02	6.60e-02	0.29400	-0.025400	-2.93e-01	8.44e-01	2.33e-02
Regulation of APC/C activators between G1/S and early anaphase	68	1.67e-05	1.72e-04	0.29400	0.022900	-2.93e-01	7.44e-01	2.93e-05
Synthesis of Ketone Bodies	6	2.28e-01	3.58e-01	0.29400	-0.127000	-2.65e-01	5.91e-01	2.61e-01
Viral Messenger RNA Synthesis	44	1.02e-02	3.78e-02	0.29400	-0.264000	1.29e-01	2.46e-03	1.38e-01
Rap1 signalling	14	2.90e-01	4.22e-01	0.29300	0.233000	-1.78e-01	1.31e-01	2.48e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	3.30e-01	4.63e-01	0.29300	0.201000	-2.14e-01	2.10e-01	1.82e-01
Sema4D induced cell migration and growth-cone collapse	19	7.51e-02	1.66e-01	0.29300	0.286000	-6.51e-02	3.10e-02	6.23e-01
Packaging Of Telomere Ends	18	1.10e-01	2.18e-01	0.29300	0.089900	-2.79e-01	5.09e-01	4.04e-02
Complex IV assembly	45	1.04e-03	5.86e-03	0.29300	-0.291000	3.68e-02	7.38e-04	6.70e-01
FRS-mediated FGFR3 signaling	12	3.59e-01	4.91e-01	0.29300	0.216000	-1.98e-01	1.94e-01	2.36e-01
MAP2K and MAPK activation	36	4.52e-02	1.15e-01	0.29200	0.225000	-1.86e-01	1.94e-02	5.28e-02
Signaling by ERBB2 ECD mutants	15	2.81e-01	4.12e-01	0.29200	0.212000	-2.01e-01	1.55e-01	1.79e-01
FGFR1 mutant receptor activation	25	1.14e-01	2.23e-01	0.29200	0.180000	-2.30e-01	1.19e-01	4.68e-02
Unwinding of DNA	12	9.37e-02	1.95e-01	0.29200	-0.038800	-2.89e-01	8.16e-01	8.27e-02
RUNX3 regulates p14-ARF	10	3.35e-01	4.67e-01	0.29200	0.269000	-1.13e-01	1.41e-01	5.35e-01
Signaling by WNT in cancer	30	7.85e-02	1.71e-01	0.29200	0.219000	-1.93e-01	3.79e-02	6.80e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	9.10e-04	5.22e-03	0.29200	-0.255000	1.42e-01	1.86e-04	3.74e-02
EPHA-mediated growth cone collapse	21	1.28e-01	2.43e-01	0.29100	0.140000	-2.55e-01	2.68e-01	4.27e-02
Dissolution of Fibrin Clot	12	4.87e-02	1.21e-01	0.29100	0.248000	1.52e-01	1.36e-01	3.63e-01
DNA Damage Recognition in GG-NER	38	6.51e-03	2.61e-02	0.29100	-0.283000	6.68e-02	2.55e-03	4.76e-01
Interleukin-12 signaling	44	1.78e-02	5.72e-02	0.29000	0.155000	-2.45e-01	7.57e-02	4.90e-03
Branched-chain amino acid catabolism	21	2.06e-02	6.38e-02	0.29000	-0.289000	-2.22e-02	2.19e-02	8.60e-01
Generation of second messenger molecules	38	2.97e-03	1.39e-02	0.29000	-0.288000	2.98e-02	2.10e-03	7.51e-01
APC/C-mediated degradation of cell cycle proteins	75	1.05e-05	1.11e-04	0.28900	0.028300	-2.88e-01	6.72e-01	1.65e-05
Regulation of mitotic cell cycle	75	1.05e-05	1.11e-04	0.28900	0.028300	-2.88e-01	6.72e-01	1.65e-05
Synthesis of PIPs at the plasma membrane	52	1.31e-02	4.59e-02	0.28900	0.219000	-1.88e-01	6.23e-03	1.91e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	7.52e-02	1.66e-01	0.28900	0.284000	4.89e-02	7.58e-02	7.60e-01
Fatty acyl-CoA biosynthesis	35	4.61e-02	1.17e-01	0.28900	0.164000	-2.37e-01	9.27e-02	1.51e-02
Acyl chain remodeling of CL	5	5.20e-01	6.29e-01	0.28800	0.065700	-2.81e-01	7.99e-01	2.77e-01
Netrin-1 signaling	34	4.81e-02	1.20e-01	0.28800	0.241000	-1.58e-01	1.51e-02	1.10e-01
Signaling by PDGF	48	7.32e-03	2.87e-02	0.28800	0.261000	-1.22e-01	1.74e-03	1.44e-01
Apoptotic factor-mediated response	19	7.71e-03	3.00e-02	0.28800	-0.205000	-2.02e-01	1.21e-01	1.28e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.08e-02	3.97e-02	0.28800	0.029700	-2.86e-01	7.78e-01	6.64e-03
mRNA Splicing	211	2.82e-17	1.32e-15	0.28700	-0.286000	-2.31e-02	7.64e-13	5.62e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	3.86e-02	1.03e-01	0.28700	-0.169000	-2.32e-01	2.91e-01	1.48e-01
Cholesterol biosynthesis	26	1.13e-01	2.22e-01	0.28700	0.178000	-2.25e-01	1.16e-01	4.70e-02
FGFR1b ligand binding and activation	5	5.08e-01	6.19e-01	0.28700	-0.281000	5.49e-02	2.76e-01	8.32e-01
Regulation of PTEN stability and activity	55	1.12e-03	6.19e-03	0.28700	0.075500	-2.77e-01	3.33e-01	3.88e-04
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.02e-02	6.33e-02	0.28600	-0.263000	-1.12e-01	6.00e-02	4.22e-01
Dual Incision in GG-NER	41	2.73e-03	1.32e-02	0.28600	-0.284000	3.89e-02	1.66e-03	6.67e-01
Formation of TC-NER Pre-Incision Complex	51	6.18e-05	5.17e-04	0.28600	-0.284000	-3.85e-02	4.53e-04	6.34e-01
Synthesis, secretion, and deacylation of Ghrelin	11	6.21e-02	1.44e-01	0.28600	-0.215000	-1.89e-01	2.16e-01	2.78e-01
Activation of the TFAP2 (AP-2) family of transcription factors	7	1.92e-01	3.19e-01	0.28600	0.127000	2.57e-01	5.61e-01	2.40e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	9	4.41e-01	5.59e-01	0.28600	0.245000	-1.47e-01	2.03e-01	4.44e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	7.40e-02	1.64e-01	0.28600	-0.270000	9.46e-02	2.50e-02	4.32e-01
FOXO-mediated transcription of cell death genes	16	2.27e-02	6.84e-02	0.28600	0.131000	2.54e-01	3.64e-01	7.84e-02
Interactions of Rev with host cellular proteins	37	2.52e-02	7.39e-02	0.28600	-0.258000	1.24e-01	6.69e-03	1.92e-01
Disorders of Developmental Biology	12	3.76e-01	5.04e-01	0.28600	0.188000	-2.15e-01	2.58e-01	1.98e-01
Disorders of Nervous System Development	12	3.76e-01	5.04e-01	0.28600	0.188000	-2.15e-01	2.58e-01	1.98e-01
Loss of function of MECP2 in Rett syndrome	12	3.76e-01	5.04e-01	0.28600	0.188000	-2.15e-01	2.58e-01	1.98e-01
Pervasive developmental disorders	12	3.76e-01	5.04e-01	0.28600	0.188000	-2.15e-01	2.58e-01	1.98e-01
Calcineurin activates NFAT	9	2.15e-01	3.42e-01	0.28500	-0.008770	-2.85e-01	9.64e-01	1.39e-01
NIK–>noncanonical NF-kB signaling	46	4.64e-04	2.90e-03	0.28400	-0.003500	-2.84e-01	9.67e-01	8.45e-04
Estrogen-dependent gene expression	96	4.51e-04	2.85e-03	0.28400	0.188000	-2.13e-01	1.48e-03	3.05e-04
G1/S Transition	120	3.52e-08	6.14e-07	0.28400	0.035100	-2.82e-01	5.07e-01	9.72e-08
Signaling by high-kinase activity BRAF mutants	33	6.92e-02	1.56e-01	0.28400	0.217000	-1.82e-01	3.07e-02	6.97e-02
PKA-mediated phosphorylation of CREB	17	2.43e-01	3.71e-01	0.28400	0.227000	-1.70e-01	1.05e-01	2.25e-01
PD-1 signaling	28	2.29e-02	6.90e-02	0.28400	-0.279000	4.96e-02	1.05e-02	6.50e-01
mRNA Splicing - Major Pathway	203	8.59e-16	3.67e-14	0.28300	-0.283000	-1.46e-02	3.70e-12	7.20e-01
Sialic acid metabolism	27	1.09e-01	2.17e-01	0.28300	0.224000	-1.72e-01	4.35e-02	1.21e-01
E3 ubiquitin ligases ubiquitinate target proteins	51	5.42e-04	3.30e-03	0.28300	0.026300	-2.82e-01	7.45e-01	5.00e-04
Semaphorin interactions	56	3.23e-03	1.49e-02	0.28300	0.260000	-1.10e-01	7.58e-04	1.53e-01
Muscle contraction	142	1.05e-05	1.11e-04	0.28200	0.222000	-1.75e-01	5.18e-06	3.11e-04
PI-3K cascade:FGFR2	13	3.58e-01	4.90e-01	0.28200	0.197000	-2.02e-01	2.19e-01	2.06e-01
TNFR1-mediated ceramide production	6	4.10e-01	5.34e-01	0.28200	-0.281000	2.38e-02	2.33e-01	9.20e-01
Signaling by ROBO receptors	189	5.25e-14	1.68e-12	0.28200	-0.282000	-5.87e-04	2.14e-11	9.89e-01
GPER1 signaling	38	4.97e-02	1.22e-01	0.28200	0.210000	-1.87e-01	2.49e-02	4.56e-02
Phospholipase C-mediated cascade: FGFR1	8	4.74e-01	5.89e-01	0.28100	-0.129000	2.50e-01	5.27e-01	2.22e-01
EPH-Ephrin signaling	79	1.71e-03	9.01e-03	0.28100	0.170000	-2.23e-01	9.02e-03	6.00e-04
Apoptosis induced DNA fragmentation	10	1.53e-01	2.77e-01	0.28100	-0.046500	-2.77e-01	7.99e-01	1.30e-01
Maturation of nucleoprotein 9694631	15	1.62e-01	2.86e-01	0.28000	0.068300	-2.72e-01	6.47e-01	6.82e-02
Nuclear import of Rev protein	34	3.72e-02	9.99e-02	0.28000	-0.254000	1.18e-01	1.04e-02	2.33e-01
Norepinephrine Neurotransmitter Release Cycle	14	8.82e-02	1.87e-01	0.28000	0.023200	2.79e-01	8.80e-01	7.07e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	3.55e-01	4.88e-01	0.27900	0.238000	-1.46e-01	1.53e-01	3.82e-01
Recognition of DNA damage by PCNA-containing replication complex	30	2.74e-03	1.33e-02	0.27900	-0.271000	-6.62e-02	1.01e-02	5.30e-01
ERBB2 Activates PTK6 Signaling	8	1.65e-01	2.88e-01	0.27900	0.126000	2.49e-01	5.38e-01	2.22e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	9	3.79e-01	5.06e-01	0.27900	0.263000	-9.24e-02	1.71e-01	6.31e-01
Defective EXT2 causes exostoses 2	9	3.79e-01	5.06e-01	0.27900	0.263000	-9.24e-02	1.71e-01	6.31e-01
Downstream signaling of activated FGFR3	17	2.66e-01	3.94e-01	0.27900	0.212000	-1.81e-01	1.30e-01	1.97e-01
Signaling by EGFR in Cancer	22	1.25e-01	2.40e-01	0.27900	0.251000	-1.21e-01	4.15e-02	3.26e-01
Peptide ligand-binding receptors	100	8.03e-08	1.33e-06	0.27800	0.278000	9.85e-03	1.51e-06	8.65e-01
Complement cascade	100	2.44e-04	1.70e-03	0.27800	0.153000	-2.33e-01	8.31e-03	5.72e-05
Phosphorylation of CD3 and TCR zeta chains	27	1.25e-02	4.42e-02	0.27800	-0.278000	-7.98e-03	1.24e-02	9.43e-01
Postmitotic nuclear pore complex (NPC) reformation	27	8.30e-02	1.78e-01	0.27800	-0.248000	1.26e-01	2.57e-02	2.58e-01
Metabolism of RNA	717	1.20e-43	1.15e-40	0.27800	-0.277000	2.71e-02	1.29e-36	2.17e-01
Protein ubiquitination	71	9.19e-05	7.38e-04	0.27800	0.045700	-2.74e-01	5.05e-01	6.47e-05
Assembly of active LPL and LIPC lipase complexes	10	2.76e-01	4.06e-01	0.27800	0.273000	-4.99e-02	1.35e-01	7.85e-01
Synthesis of PIPs at the early endosome membrane	16	7.61e-02	1.67e-01	0.27800	-0.006500	-2.78e-01	9.64e-01	5.46e-02
ER-Phagosome pathway	74	2.61e-06	3.19e-05	0.27700	-0.029900	-2.76e-01	6.56e-01	4.11e-05
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	9.16e-02	1.91e-01	0.27700	-0.263000	8.70e-02	3.26e-02	4.80e-01
Platelet activation, signaling and aggregation	219	7.18e-08	1.21e-06	0.27700	0.198000	-1.94e-01	4.60e-07	7.87e-07
Synthesis of PIPs at the late endosome membrane	11	1.07e-01	2.14e-01	0.27700	-0.085400	-2.63e-01	6.24e-01	1.31e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	29	1.24e-02	4.41e-02	0.27600	0.007580	-2.76e-01	9.44e-01	9.99e-03
SUMOylation of SUMOylation proteins	35	5.01e-02	1.23e-01	0.27600	-0.238000	1.41e-01	1.48e-02	1.50e-01
Interleukin-27 signaling	11	3.73e-01	5.03e-01	0.27600	0.128000	-2.45e-01	4.61e-01	1.60e-01
Myogenesis	20	6.66e-02	1.52e-01	0.27600	0.274000	-3.49e-02	3.39e-02	7.87e-01
EML4 and NUDC in mitotic spindle formation	106	4.55e-06	5.33e-05	0.27600	0.069200	-2.67e-01	2.18e-01	2.00e-06
Aerobic respiration and respiratory electron transport	245	6.16e-18	3.03e-16	0.27600	-0.275000	-1.40e-02	1.09e-13	7.07e-01
p75NTR recruits signalling complexes	12	3.91e-01	5.17e-01	0.27600	-0.167000	2.19e-01	3.16e-01	1.88e-01
Nephron development	5	6.64e-01	7.45e-01	0.27500	0.231000	-1.50e-01	3.71e-01	5.62e-01
Signaling by FGFR1 in disease	32	8.95e-02	1.89e-01	0.27500	0.182000	-2.06e-01	7.43e-02	4.37e-02
Peptide hormone metabolism	53	1.32e-02	4.60e-02	0.27500	0.149000	-2.31e-01	6.03e-02	3.63e-03
Interleukin-12 family signaling	53	1.21e-02	4.35e-02	0.27500	0.144000	-2.34e-01	7.07e-02	3.15e-03
Removal of the Flap Intermediate from the C-strand	17	1.90e-02	6.02e-02	0.27500	-0.192000	-1.97e-01	1.71e-01	1.60e-01
RHOB GTPase cycle	64	1.59e-03	8.52e-03	0.27500	0.256000	-9.86e-02	3.87e-04	1.73e-01
Erythropoietin activates STAT5	6	6.24e-01	7.14e-01	0.27500	0.223000	-1.61e-01	3.45e-01	4.95e-01
Membrane Trafficking	575	8.01e-21	4.40e-19	0.27500	0.146000	-2.33e-01	2.11e-09	1.48e-21
Cyclin D associated events in G1	47	7.58e-03	2.97e-02	0.27500	0.091500	-2.59e-01	2.78e-01	2.13e-03
G1 Phase	47	7.58e-03	2.97e-02	0.27500	0.091500	-2.59e-01	2.78e-01	2.13e-03
TLR3-mediated TICAM1-dependent programmed cell death	6	5.83e-01	6.79e-01	0.27400	0.124000	-2.45e-01	6.00e-01	2.99e-01
Transcriptional regulation of pluripotent stem cells	18	2.35e-01	3.66e-01	0.27400	0.153000	-2.28e-01	2.63e-01	9.40e-02
Separation of Sister Chromatids	167	4.71e-10	1.01e-08	0.27400	0.042200	-2.71e-01	3.47e-01	1.50e-09
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	2.62e-02	7.67e-02	0.27400	0.257000	-9.69e-02	7.71e-03	3.15e-01
Formation of Incision Complex in GG-NER	43	1.03e-03	5.83e-03	0.27400	-0.274000	-1.18e-02	1.88e-03	8.94e-01
G2/M Checkpoints	126	4.31e-07	6.17e-06	0.27400	0.065200	-2.66e-01	2.07e-01	2.42e-07
Thromboxane signalling through TP receptor	20	1.92e-01	3.19e-01	0.27400	0.233000	-1.44e-01	7.13e-02	2.64e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	2.16e-05	2.11e-04	0.27400	-0.271000	4.38e-02	1.82e-05	4.88e-01
FRS-mediated FGFR4 signaling	13	3.79e-01	5.06e-01	0.27400	0.203000	-1.84e-01	2.05e-01	2.52e-01
Glucagon-type ligand receptors	19	1.73e-01	2.99e-01	0.27400	0.116000	-2.48e-01	3.82e-01	6.15e-02
Antigen processing-Cross presentation	88	5.23e-06	6.01e-05	0.27300	0.024000	-2.72e-01	6.97e-01	1.01e-05
PTK6 promotes HIF1A stabilization	6	4.77e-01	5.90e-01	0.27300	0.268000	-5.11e-02	2.55e-01	8.28e-01
Metalloprotease DUBs	20	2.26e-01	3.56e-01	0.27300	0.181000	-2.04e-01	1.61e-01	1.14e-01
Integration of energy metabolism	87	7.00e-04	4.13e-03	0.27300	0.236000	-1.37e-01	1.45e-04	2.68e-02
DNA Damage Bypass	47	4.95e-05	4.28e-04	0.27200	-0.246000	-1.16e-01	3.53e-03	1.67e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	2.39e-02	7.10e-02	0.27200	0.002380	-2.72e-01	9.84e-01	1.86e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	2.39e-02	7.10e-02	0.27200	0.002380	-2.72e-01	9.84e-01	1.86e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	2.39e-02	7.10e-02	0.27200	0.002380	-2.72e-01	9.84e-01	1.86e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	2.39e-02	7.10e-02	0.27200	0.002380	-2.72e-01	9.84e-01	1.86e-02
Formation of paraxial mesoderm	52	1.22e-02	4.37e-02	0.27100	0.131000	-2.38e-01	1.02e-01	3.01e-03
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	16	1.54e-01	2.78e-01	0.27100	0.059900	-2.65e-01	6.78e-01	6.69e-02
Nucleotide Excision Repair	108	1.29e-06	1.72e-05	0.27100	-0.268000	4.26e-02	1.51e-06	4.45e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	5.72e-02	1.36e-01	0.27100	-0.147000	-2.28e-01	3.60e-01	1.55e-01
RSK activation	7	5.21e-01	6.30e-01	0.27100	0.108000	-2.48e-01	6.20e-01	2.55e-01
APC/C:Cdc20 mediated degradation of Securin	55	7.89e-05	6.45e-04	0.27000	-0.041300	-2.67e-01	5.96e-01	6.14e-04
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	9.20e-02	1.92e-01	0.27000	-0.265000	5.27e-02	4.04e-02	6.83e-01
Recycling pathway of L1	40	4.17e-02	1.08e-01	0.27000	0.228000	-1.44e-01	1.25e-02	1.15e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	6.99e-04	4.13e-03	0.26900	-0.257000	-8.02e-02	6.06e-03	3.93e-01
Sema4D in semaphorin signaling	22	6.18e-02	1.44e-01	0.26900	0.267000	-3.80e-02	3.04e-02	7.58e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	4.50e-02	1.15e-01	0.26900	-0.167000	-2.11e-01	2.79e-01	1.72e-01
Acetylcholine Neurotransmitter Release Cycle	11	2.83e-01	4.14e-01	0.26900	-0.059600	2.62e-01	7.32e-01	1.32e-01
Cyclin A:Cdk2-associated events at S phase entry	75	2.48e-04	1.71e-03	0.26900	0.066500	-2.60e-01	3.19e-01	9.61e-05
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	23	1.17e-01	2.28e-01	0.26900	0.104000	-2.48e-01	3.90e-01	3.97e-02
Branched-chain ketoacid dehydrogenase kinase deficiency	5	5.36e-01	6.42e-01	0.26800	-0.265000	3.98e-02	3.04e-01	8.77e-01
KEAP1-NFE2L2 pathway	106	5.55e-04	3.36e-03	0.26800	0.188000	-1.90e-01	8.06e-04	7.03e-04
RNA Polymerase II Transcription Termination	66	4.76e-04	2.97e-03	0.26800	-0.262000	5.43e-02	2.32e-04	4.46e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	7.00e-02	1.57e-01	0.26700	0.072700	-2.57e-01	5.29e-01	2.60e-02
Removal of the Flap Intermediate	14	9.30e-02	1.94e-01	0.26700	-0.263000	-4.40e-02	8.80e-02	7.76e-01
Signaling by FGFR3 in disease	14	3.61e-01	4.93e-01	0.26700	0.211000	-1.63e-01	1.72e-01	2.90e-01
Hedgehog ‘on’ state	65	9.51e-04	5.44e-03	0.26700	0.069800	-2.57e-01	3.31e-01	3.33e-04
Beta-oxidation of pristanoyl-CoA	9	1.80e-01	3.05e-01	0.26600	-0.086900	-2.52e-01	6.52e-01	1.91e-01
RHOV GTPase cycle	36	2.65e-02	7.72e-02	0.26600	0.082100	-2.53e-01	3.94e-01	8.52e-03
Synthesis of very long-chain fatty acyl-CoAs	22	1.97e-01	3.24e-01	0.26600	0.156000	-2.16e-01	2.06e-01	7.99e-02
Voltage gated Potassium channels	26	9.09e-03	3.47e-02	0.26600	0.257000	6.77e-02	2.32e-02	5.50e-01
Signaling by TGF-beta Receptor Complex in Cancer	8	1.77e-01	3.02e-01	0.26600	-0.167000	-2.07e-01	4.14e-01	3.10e-01
Downstream signaling of activated FGFR4	18	2.79e-01	4.10e-01	0.26600	0.203000	-1.72e-01	1.36e-01	2.07e-01
Dectin-1 mediated noncanonical NF-kB signaling	47	1.38e-03	7.45e-03	0.26500	0.005790	-2.65e-01	9.45e-01	1.65e-03
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7	5.16e-01	6.26e-01	0.26500	0.248000	-9.40e-02	2.56e-01	6.67e-01
CD28 dependent PI3K/Akt signaling	22	1.87e-01	3.13e-01	0.26500	-0.143000	2.23e-01	2.45e-01	7.01e-02
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	8	1.77e-01	3.02e-01	0.26500	0.186000	1.88e-01	3.62e-01	3.57e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	1.44e-01	2.65e-01	0.26400	0.007100	-2.64e-01	9.63e-01	8.68e-02
Processing of Capped Intronless Pre-mRNA	29	2.71e-02	7.84e-02	0.26400	-0.262000	3.19e-02	1.46e-02	7.66e-01
Phosphate bond hydrolysis by NTPDase proteins	6	5.61e-01	6.63e-01	0.26300	-0.249000	8.67e-02	2.91e-01	7.13e-01
TYSND1 cleaves peroxisomal proteins	7	3.28e-01	4.61e-01	0.26300	-0.261000	-3.24e-02	2.31e-01	8.82e-01
Dual incision in TC-NER	63	5.56e-05	4.66e-04	0.26300	-0.262000	-2.65e-02	3.24e-04	7.16e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	6.22e-02	1.44e-01	0.26300	0.135000	-2.26e-01	1.62e-01	1.90e-02
Transcriptional regulation by RUNX1	170	9.57e-06	1.04e-04	0.26300	0.183000	-1.89e-01	3.84e-05	2.16e-05
FRS-mediated FGFR2 signaling	15	3.53e-01	4.88e-01	0.26300	0.170000	-2.01e-01	2.54e-01	1.79e-01
Respiratory syncytial virus (RSV) attachment and entry	17	1.87e-01	3.14e-01	0.26300	0.250000	-8.01e-02	7.43e-02	5.67e-01
Adenylate cyclase inhibitory pathway	11	1.58e-01	2.83e-01	0.26200	0.257000	5.05e-02	1.39e-01	7.72e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	90	9.19e-06	1.01e-04	0.26200	0.020100	-2.62e-01	7.42e-01	1.80e-05
Amplification of signal from the kinetochores	90	9.19e-06	1.01e-04	0.26200	0.020100	-2.62e-01	7.42e-01	1.80e-05
Cobalamin (Cbl, vitamin B12) transport and metabolism	17	1.34e-01	2.53e-01	0.26200	0.040900	-2.59e-01	7.70e-01	6.44e-02
Pre-NOTCH Expression and Processing	63	1.36e-02	4.71e-02	0.26200	0.194000	-1.76e-01	7.63e-03	1.56e-02
Sodium/Calcium exchangers	9	5.28e-01	6.36e-01	0.26200	0.210000	-1.57e-01	2.75e-01	4.15e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	6.91e-02	1.56e-01	0.26200	0.085300	-2.48e-01	4.35e-01	2.34e-02
Signaling by LTK	10	3.56e-01	4.89e-01	0.26200	0.253000	-6.89e-02	1.67e-01	7.06e-01
Signaling by NTRK2 (TRKB)	20	2.30e-01	3.60e-01	0.26200	0.145000	-2.18e-01	2.63e-01	9.14e-02
Assembly of the pre-replicative complex	87	1.44e-06	1.89e-05	0.26100	-0.030400	-2.59e-01	6.25e-01	2.99e-05
Transport of Mature mRNAs Derived from Intronless Transcripts	43	4.97e-02	1.22e-01	0.26100	-0.208000	1.57e-01	1.84e-02	7.45e-02
Impaired BRCA2 binding to PALB2	24	3.24e-02	9.10e-02	0.26100	-0.008140	-2.60e-01	9.45e-01	2.72e-02
FGFR1c ligand binding and activation	8	5.53e-01	6.55e-01	0.26000	-0.139000	2.20e-01	4.95e-01	2.81e-01
Pre-NOTCH Processing in the Endoplasmic Reticulum	6	6.30e-01	7.20e-01	0.26000	0.226000	-1.29e-01	3.37e-01	5.85e-01
MECP2 regulates transcription of neuronal ligands	5	3.80e-01	5.06e-01	0.26000	-0.113000	-2.34e-01	6.61e-01	3.64e-01
Regulation of TLR by endogenous ligand	15	2.05e-01	3.31e-01	0.26000	0.060100	-2.53e-01	6.87e-01	9.01e-02
Regulation of RUNX2 expression and activity	54	5.56e-04	3.36e-03	0.25900	-0.003130	-2.59e-01	9.68e-01	9.72e-04
Degradation of the extracellular matrix	92	1.14e-04	8.97e-04	0.25900	0.249000	-7.33e-02	3.68e-05	2.24e-01
G1/S DNA Damage Checkpoints	54	1.85e-03	9.65e-03	0.25900	0.038200	-2.57e-01	6.27e-01	1.10e-03
SARS-CoV-1-host interactions	94	1.87e-05	1.90e-04	0.25900	-0.256000	3.91e-02	1.72e-05	5.12e-01
Loss of Function of SMAD2/3 in Cancer	7	2.40e-01	3.69e-01	0.25900	-0.212000	-1.50e-01	3.32e-01	4.93e-01
Fanconi Anemia Pathway	36	6.66e-03	2.66e-02	0.25900	-0.259000	-4.77e-03	7.18e-03	9.60e-01
Downregulation of ERBB4 signaling	8	1.96e-01	3.22e-01	0.25900	-0.154000	-2.08e-01	4.51e-01	3.08e-01
Mismatch Repair	15	6.19e-02	1.44e-01	0.25900	-0.097700	-2.39e-01	5.13e-01	1.08e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.48e-17	7.12e-16	0.25800	-0.258000	-7.65e-03	1.09e-13	8.26e-01
RHOJ GTPase cycle	49	1.75e-02	5.65e-02	0.25800	0.234000	-1.09e-01	4.52e-03	1.88e-01
Gluconeogenesis	19	2.74e-01	4.03e-01	0.25800	0.204000	-1.59e-01	1.24e-01	2.30e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.10e-01	2.17e-01	0.25800	-0.254000	4.79e-02	4.94e-02	7.11e-01
Synthesis of PIPs at the Golgi membrane	16	3.13e-01	4.48e-01	0.25800	-0.138000	2.18e-01	3.39e-01	1.31e-01
Formation of the cornified envelope	33	4.03e-02	1.06e-01	0.25800	0.247000	-7.38e-02	1.40e-02	4.63e-01
Regulation of CDH11 function	9	3.74e-01	5.03e-01	0.25800	0.253000	-4.99e-02	1.89e-01	7.96e-01
Signal transduction by L1	20	2.62e-01	3.91e-01	0.25800	0.198000	-1.65e-01	1.24e-01	2.02e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	2.06e-01	3.32e-01	0.25800	0.188000	-1.76e-01	1.10e-01	1.35e-01
Protein hydroxylation	17	2.11e-01	3.39e-01	0.25800	-0.243000	8.65e-02	8.30e-02	5.37e-01
Signaling by WNT	237	9.28e-08	1.52e-06	0.25700	0.151000	-2.08e-01	6.40e-05	3.20e-08
Downstream signaling of activated FGFR2	20	2.70e-01	3.98e-01	0.25700	0.178000	-1.86e-01	1.68e-01	1.51e-01
SUMOylation of RNA binding proteins	47	3.40e-02	9.38e-02	0.25700	-0.217000	1.37e-01	9.95e-03	1.05e-01
Citric acid cycle (TCA cycle)	34	3.21e-03	1.49e-02	0.25600	-0.247000	-6.73e-02	1.25e-02	4.97e-01
RNA Polymerase III Transcription Initiation	36	4.61e-02	1.17e-01	0.25600	-0.237000	9.74e-02	1.38e-02	3.12e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	2.07e-04	1.46e-03	0.25600	-0.256000	-6.91e-03	4.98e-04	9.25e-01
Synthesis of Dolichyl-phosphate	6	6.61e-01	7.43e-01	0.25500	0.210000	-1.46e-01	3.74e-01	5.36e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	4.12e-01	5.35e-01	0.25500	0.087800	-2.40e-01	6.31e-01	1.89e-01
G alpha (z) signalling events	36	7.71e-02	1.69e-01	0.25500	0.216000	-1.35e-01	2.47e-02	1.61e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	17	2.25e-01	3.54e-01	0.25400	0.087000	-2.38e-01	5.35e-01	8.87e-02
Early SARS-CoV-2 Infection Events	30	7.22e-02	1.61e-01	0.25400	0.087100	-2.38e-01	4.09e-01	2.39e-02
Gap junction degradation	11	4.80e-01	5.93e-01	0.25300	0.205000	-1.48e-01	2.39e-01	3.94e-01
Gastrulation	73	8.49e-03	3.26e-02	0.25300	0.155000	-2.00e-01	2.21e-02	3.12e-03
Adherens junctions interactions	37	4.76e-02	1.19e-01	0.25300	0.233000	-9.80e-02	1.42e-02	3.02e-01
Mitophagy	38	6.96e-04	4.12e-03	0.25300	-0.212000	-1.38e-01	2.40e-02	1.41e-01
Signaling by MET	67	1.47e-02	5.00e-02	0.25300	0.176000	-1.81e-01	1.29e-02	1.02e-02
Acetylcholine regulates insulin secretion	9	1.94e-01	3.21e-01	0.25200	0.110000	2.27e-01	5.67e-01	2.38e-01
Cellular responses to mechanical stimuli	83	1.91e-03	9.88e-03	0.25200	0.225000	-1.14e-01	4.03e-04	7.27e-02
Response of endothelial cells to shear stress	83	1.91e-03	9.88e-03	0.25200	0.225000	-1.14e-01	4.03e-04	7.27e-02
Interleukin-1 processing	8	3.88e-01	5.14e-01	0.25200	-0.020500	2.51e-01	9.20e-01	2.19e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	6.76e-02	1.54e-01	0.25100	-0.197000	1.57e-01	2.76e-02	7.84e-02
MET receptor recycling	9	5.68e-01	6.67e-01	0.25100	0.188000	-1.67e-01	3.30e-01	3.87e-01
Transport of Mature Transcript to Cytoplasm	81	2.49e-03	1.23e-02	0.25100	-0.223000	1.16e-01	5.36e-04	7.11e-02
Signaling by Interleukins	387	1.18e-11	3.10e-10	0.25100	0.205000	-1.45e-01	4.39e-12	1.03e-06
RHO GTPases Activate Formins	127	1.26e-05	1.32e-04	0.25000	0.077100	-2.38e-01	1.34e-01	3.55e-06
Folding of actin by CCT/TriC	10	1.82e-01	3.06e-01	0.25000	-0.087700	-2.34e-01	6.31e-01	2.00e-01
Interleukin-6 family signaling	18	3.23e-01	4.57e-01	0.25000	0.191000	-1.61e-01	1.60e-01	2.37e-01
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	60	1.87e-02	5.97e-02	0.25000	0.207000	-1.40e-01	5.57e-03	6.11e-02
WNT mediated activation of DVL	8	2.20e-01	3.48e-01	0.25000	0.147000	2.02e-01	4.72e-01	3.23e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	61	1.73e-04	1.27e-03	0.25000	-0.029100	-2.48e-01	6.94e-01	8.10e-04
p75NTR signals via NF-kB	15	1.62e-01	2.85e-01	0.25000	-0.010600	2.49e-01	9.43e-01	9.45e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	7.23e-02	1.61e-01	0.24900	-0.141000	-2.05e-01	3.59e-01	1.84e-01
Mitotic Anaphase	210	1.99e-10	4.35e-09	0.24900	0.037500	-2.46e-01	3.49e-01	7.49e-10
Post-chaperonin tubulin folding pathway	18	3.31e-01	4.64e-01	0.24900	0.182000	-1.69e-01	1.80e-01	2.14e-01
Mitotic Metaphase and Anaphase	211	1.92e-10	4.25e-09	0.24800	0.036500	-2.46e-01	3.60e-01	7.67e-10
TGF-beta receptor signaling activates SMADs	45	4.92e-02	1.21e-01	0.24800	0.134000	-2.09e-01	1.21e-01	1.51e-02
RAC2 GTPase cycle	85	3.22e-03	1.49e-02	0.24800	0.211000	-1.31e-01	7.73e-04	3.69e-02
Constitutive Signaling by AKT1 E17K in Cancer	25	1.56e-02	5.20e-02	0.24800	0.083500	2.34e-01	4.70e-01	4.31e-02
Innate Immune System	966	1.62e-26	1.56e-24	0.24800	0.144000	-2.02e-01	4.26e-14	2.37e-26
GP1b-IX-V activation signalling	10	4.38e-01	5.56e-01	0.24700	0.232000	-8.73e-02	2.05e-01	6.33e-01
Switching of origins to a post-replicative state	79	1.13e-05	1.20e-04	0.24700	-0.039100	-2.44e-01	5.48e-01	1.77e-04
Defects in vitamin and cofactor metabolism	21	4.77e-02	1.19e-01	0.24700	-0.243000	-4.06e-02	5.35e-02	7.48e-01
ATF4 activates genes in response to endoplasmic reticulum stress	25	1.59e-01	2.84e-01	0.24700	-0.221000	1.09e-01	5.54e-02	3.47e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	76	2.03e-05	2.02e-04	0.24600	-0.037500	-2.43e-01	5.72e-01	2.48e-04
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	5.40e-01	6.46e-01	0.24500	-0.194000	1.49e-01	2.87e-01	4.15e-01
Regulation of CDH11 gene transcription	5	4.22e-01	5.44e-01	0.24400	0.111000	2.18e-01	6.67e-01	3.99e-01
Molecules associated with elastic fibres	26	1.55e-01	2.78e-01	0.24400	0.219000	-1.09e-01	5.34e-02	3.37e-01
Na+/Cl- dependent neurotransmitter transporters	7	4.77e-01	5.90e-01	0.24400	0.242000	-3.11e-02	2.67e-01	8.87e-01
DNA strand elongation	32	6.99e-03	2.77e-02	0.24400	-0.234000	-6.88e-02	2.19e-02	5.01e-01
rRNA processing in the mitochondrion	24	1.72e-01	2.97e-01	0.24400	-0.221000	1.03e-01	6.09e-02	3.82e-01
ESR-mediated signaling	157	1.02e-04	8.12e-04	0.24400	0.175000	-1.70e-01	1.53e-04	2.40e-04
ABC-family proteins mediated transport	81	1.83e-03	9.57e-03	0.24400	0.090900	-2.26e-01	1.57e-01	4.31e-04
Small interfering RNA (siRNA) biogenesis	9	2.39e-01	3.68e-01	0.24400	-0.078300	-2.31e-01	6.84e-01	2.31e-01
RHOU GTPase cycle	40	9.51e-02	1.96e-01	0.24300	0.162000	-1.81e-01	7.66e-02	4.71e-02
CDK-mediated phosphorylation and removal of Cdc6	60	7.93e-04	4.62e-03	0.24300	0.002410	-2.43e-01	9.74e-01	1.13e-03
Keratan sulfate/keratin metabolism	27	1.60e-01	2.84e-01	0.24300	0.213000	-1.17e-01	5.59e-02	2.91e-01
MAPK family signaling cascades	259	3.00e-07	4.41e-06	0.24300	0.163000	-1.80e-01	6.62e-06	5.92e-07
Regulation of Expression and Function of Type II Classical Cadherins	23	1.45e-01	2.66e-01	0.24200	0.231000	-7.34e-02	5.53e-02	5.42e-01
Regulation of Homotypic Cell-Cell Adhesion	23	1.45e-01	2.66e-01	0.24200	0.231000	-7.34e-02	5.53e-02	5.42e-01
Nitric oxide stimulates guanylate cyclase	15	8.29e-02	1.78e-01	0.24200	0.100000	2.21e-01	5.02e-01	1.39e-01
Beta-catenin independent WNT signaling	124	5.07e-04	3.11e-03	0.24200	0.140000	-1.98e-01	7.23e-03	1.44e-04
Cristae formation	33	1.35e-02	4.71e-02	0.24200	-0.241000	-2.19e-02	1.66e-02	8.27e-01
Hyaluronan metabolism	15	6.77e-02	1.54e-01	0.24200	0.185000	1.56e-01	2.15e-01	2.97e-01
Estrogen-stimulated signaling through PRKCZ	6	5.61e-01	6.62e-01	0.24200	0.045400	-2.37e-01	8.47e-01	3.14e-01
mRNA 3’-end processing	57	4.55e-03	1.99e-02	0.24100	-0.236000	4.83e-02	2.02e-03	5.28e-01
A tetrasaccharide linker sequence is required for GAG synthesis	16	9.44e-02	1.95e-01	0.24100	0.058700	2.34e-01	6.85e-01	1.05e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	2.80e-01	4.11e-01	0.24100	-0.017100	-2.40e-01	9.26e-01	1.88e-01
FLT3 Signaling	38	1.00e-01	2.04e-01	0.24100	0.195000	-1.41e-01	3.72e-02	1.32e-01
RNA Polymerase III Abortive And Retractive Initiation	40	5.87e-02	1.38e-01	0.24100	-0.217000	1.04e-01	1.74e-02	2.55e-01
RNA Polymerase III Transcription	40	5.87e-02	1.38e-01	0.24100	-0.217000	1.04e-01	1.74e-02	2.55e-01
RET signaling	32	8.03e-02	1.74e-01	0.24100	0.226000	-8.25e-02	2.69e-02	4.19e-01
Regulation of RUNX3 expression and activity	45	7.64e-03	2.98e-02	0.24000	0.018700	-2.40e-01	8.28e-01	5.40e-03
p53-Dependent G1 DNA Damage Response	52	4.45e-03	1.95e-02	0.24000	0.026900	-2.39e-01	7.37e-01	2.88e-03
p53-Dependent G1/S DNA damage checkpoint	52	4.45e-03	1.95e-02	0.24000	0.026900	-2.39e-01	7.37e-01	2.88e-03
Defective factor IX causes hemophilia B	6	6.21e-01	7.12e-01	0.24000	0.226000	-8.07e-02	3.37e-01	7.32e-01
Trafficking of GluR2-containing AMPA receptors	11	4.50e-01	5.66e-01	0.24000	0.219000	-9.74e-02	2.08e-01	5.76e-01
Formation of tubulin folding intermediates by CCT/TriC	21	2.94e-01	4.26e-01	0.24000	0.150000	-1.87e-01	2.34e-01	1.38e-01
PIWI-interacting RNA (piRNA) biogenesis	23	1.84e-02	5.89e-02	0.24000	-0.196000	-1.38e-01	1.03e-01	2.53e-01
TGFBR3 regulates TGF-beta signaling	8	3.01e-01	4.34e-01	0.23900	-0.229000	-7.01e-02	2.63e-01	7.31e-01
RND3 GTPase cycle	35	1.36e-01	2.54e-01	0.23800	0.183000	-1.53e-01	6.14e-02	1.18e-01
Signaling by FGFR3	32	1.50e-01	2.72e-01	0.23800	0.139000	-1.94e-01	1.75e-01	5.79e-02
Metabolism of nitric oxide: NOS3 activation and regulation	13	1.21e-01	2.34e-01	0.23800	-0.103000	-2.14e-01	5.18e-01	1.81e-01
Activation of Ca-permeable Kainate Receptor	8	6.12e-01	7.04e-01	0.23800	0.129000	-2.00e-01	5.28e-01	3.27e-01
Ionotropic activity of kainate receptors	8	6.12e-01	7.04e-01	0.23800	0.129000	-2.00e-01	5.28e-01	3.27e-01
NRIF signals cell death from the nucleus	15	1.83e-01	3.08e-01	0.23800	-0.238000	3.92e-03	1.11e-01	9.79e-01
Physiological factors	9	5.99e-01	6.94e-01	0.23700	0.150000	-1.84e-01	4.36e-01	3.39e-01
Metabolism of amino acids and derivatives	304	8.09e-15	2.93e-13	0.23700	-0.237000	1.34e-02	1.21e-12	6.87e-01
Ketone body metabolism	8	2.93e-01	4.25e-01	0.23700	-0.083000	-2.22e-01	6.84e-01	2.77e-01
RHOA GTPase cycle	138	1.42e-04	1.07e-03	0.23700	0.207000	-1.15e-01	2.62e-05	1.94e-02
Potassium Channels	62	1.16e-03	6.41e-03	0.23700	0.237000	-1.09e-02	1.26e-03	8.82e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	1.45e-01	2.66e-01	0.23700	-0.198000	1.30e-01	5.27e-02	2.02e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	1.45e-01	2.66e-01	0.23700	-0.198000	1.30e-01	5.27e-02	2.02e-01
Respiratory Syncytial Virus Infection Pathway	97	5.08e-06	5.91e-05	0.23600	-0.025300	-2.35e-01	6.66e-01	6.48e-05
Transferrin endocytosis and recycling	26	1.26e-01	2.41e-01	0.23600	0.225000	-7.14e-02	4.72e-02	5.28e-01
Organic anion transporters	7	5.57e-01	6.59e-01	0.23600	-0.227000	6.26e-02	2.97e-01	7.74e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	1.28e-01	2.43e-01	0.23500	0.111000	-2.07e-01	2.76e-01	4.25e-02
Signaling by RAF1 mutants	36	1.40e-01	2.60e-01	0.23500	0.169000	-1.63e-01	7.86e-02	9.14e-02
Defects of platelet adhesion to exposed collagen	6	5.52e-01	6.55e-01	0.23500	0.233000	-2.73e-02	3.23e-01	9.08e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.13e-01	2.21e-01	0.23400	-0.223000	7.33e-02	4.13e-02	5.02e-01
FGFR3 ligand binding and activation	5	7.59e-01	8.24e-01	0.23400	0.179000	-1.51e-01	4.88e-01	5.59e-01
FGFR3c ligand binding and activation	5	7.59e-01	8.24e-01	0.23400	0.179000	-1.51e-01	4.88e-01	5.59e-01
Release of apoptotic factors from the mitochondria	6	4.14e-01	5.37e-01	0.23400	-0.221000	-7.58e-02	3.48e-01	7.48e-01
AKT phosphorylates targets in the cytosol	14	9.53e-02	1.96e-01	0.23300	0.157000	1.73e-01	3.10e-01	2.63e-01
Signaling by Rho GTPases	603	1.77e-14	5.96e-13	0.23300	0.160000	-1.70e-01	2.20e-11	9.67e-13
Regulation of CDH11 Expression and Function	22	2.59e-01	3.88e-01	0.23300	0.202000	-1.17e-01	1.01e-01	3.43e-01
Blood group systems biosynthesis	16	4.23e-01	5.45e-01	0.23300	-0.163000	1.67e-01	2.60e-01	2.47e-01
Mitotic G2-G2/M phases	179	5.11e-07	7.06e-06	0.23300	0.061300	-2.24e-01	1.57e-01	2.21e-07
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	3.15e-01	4.50e-01	0.23200	0.106000	-2.07e-01	4.38e-01	1.28e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	3.15e-01	4.50e-01	0.23200	0.106000	-2.07e-01	4.38e-01	1.28e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	3.34e-02	9.26e-02	0.23200	-0.193000	-1.29e-01	1.26e-01	3.06e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	3.34e-02	9.26e-02	0.23200	-0.193000	-1.29e-01	1.26e-01	3.06e-01
Metabolism of fat-soluble vitamins	26	5.54e-02	1.33e-01	0.23200	0.231000	4.20e-03	4.10e-02	9.70e-01
Cell Cycle Checkpoints	245	3.97e-11	9.79e-10	0.23100	0.021700	-2.30e-01	5.59e-01	5.21e-10
Integrin cell surface interactions	64	2.22e-02	6.77e-02	0.23100	0.198000	-1.19e-01	6.03e-03	9.99e-02
G2/M Transition	177	7.96e-07	1.08e-05	0.23100	0.061900	-2.23e-01	1.55e-01	3.24e-07
RHOD GTPase cycle	49	5.69e-02	1.36e-01	0.23100	0.196000	-1.22e-01	1.75e-02	1.39e-01
Autodegradation of Cdh1 by Cdh1:APC/C	54	5.51e-04	3.35e-03	0.23100	-0.065600	-2.21e-01	4.04e-01	4.90e-03
Keratinization	34	5.46e-02	1.32e-01	0.23100	0.226000	-4.87e-02	2.28e-02	6.23e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	619	1.60e-14	5.49e-13	0.23100	0.159000	-1.68e-01	1.66e-11	1.08e-12
APC-Cdc20 mediated degradation of Nek2A	26	1.50e-02	5.07e-02	0.23100	-0.186000	-1.36e-01	9.99e-02	2.31e-01
Signaling by NTRK3 (TRKC)	15	3.74e-01	5.03e-01	0.23100	0.209000	-9.79e-02	1.62e-01	5.11e-01
Suppression of apoptosis	7	5.44e-01	6.49e-01	0.23000	0.226000	-4.50e-02	3.00e-01	8.37e-01
Negative regulators of DDX58/IFIH1 signaling	34	4.34e-03	1.93e-02	0.23000	-0.189000	-1.31e-01	5.61e-02	1.86e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	2.67e-01	3.95e-01	0.23000	-0.229000	-2.50e-02	1.89e-01	8.86e-01
Budding and maturation of HIV virion	26	5.61e-02	1.35e-01	0.23000	-0.006830	-2.30e-01	9.52e-01	4.27e-02
NOTCH4 Intracellular Domain Regulates Transcription	17	7.31e-02	1.62e-01	0.22900	0.201000	1.10e-01	1.51e-01	4.32e-01
PKR-mediated signaling	67	2.10e-03	1.07e-02	0.22900	0.031400	-2.27e-01	6.57e-01	1.30e-03
RAF activation	32	9.07e-02	1.91e-01	0.22900	0.069700	-2.18e-01	4.95e-01	3.27e-02
MET promotes cell motility	32	1.66e-01	2.89e-01	0.22900	0.190000	-1.27e-01	6.22e-02	2.13e-01
Regulation of BACH1 activity	11	1.70e-01	2.95e-01	0.22900	-0.174000	-1.49e-01	3.17e-01	3.93e-01
Formation of annular gap junctions	10	5.88e-01	6.85e-01	0.22900	0.179000	-1.43e-01	3.28e-01	4.35e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	1.26e-01	2.41e-01	0.22800	-0.070300	-2.17e-01	6.37e-01	1.45e-01
DNA Damage Reversal	8	6.54e-01	7.36e-01	0.22800	-0.180000	1.40e-01	3.78e-01	4.93e-01
MAPK1/MAPK3 signaling	227	9.29e-06	1.02e-04	0.22800	0.158000	-1.65e-01	4.20e-05	1.90e-05
Processive synthesis on the C-strand of the telomere	19	4.92e-02	1.21e-01	0.22800	-0.181000	-1.38e-01	1.71e-01	2.97e-01
IRF3-mediated induction of type I IFN	12	5.29e-01	6.37e-01	0.22800	-0.180000	1.40e-01	2.80e-01	4.03e-01
Mitotic Prometaphase	192	7.79e-08	1.30e-06	0.22800	0.042100	-2.24e-01	3.14e-01	8.95e-08
Purine salvage	12	3.09e-01	4.44e-01	0.22800	0.016300	-2.27e-01	9.22e-01	1.73e-01
Activation of NOXA and translocation to mitochondria	5	4.57e-01	5.73e-01	0.22700	-0.186000	-1.31e-01	4.71e-01	6.12e-01
Formation of axial mesoderm	6	4.96e-01	6.08e-01	0.22700	0.226000	2.36e-02	3.37e-01	9.20e-01
Formation of the Early Elongation Complex	33	4.57e-02	1.16e-01	0.22700	-0.226000	2.47e-02	2.47e-02	8.06e-01
Formation of the HIV-1 Early Elongation Complex	33	4.57e-02	1.16e-01	0.22700	-0.226000	2.47e-02	2.47e-02	8.06e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	1.71e-03	9.01e-03	0.22700	-0.157000	-1.64e-01	8.56e-02	7.24e-02
Base Excision Repair	56	2.87e-03	1.37e-02	0.22700	-0.227000	7.92e-04	3.30e-03	9.92e-01
Diseases of DNA repair	50	4.91e-04	3.03e-03	0.22700	-0.195000	-1.16e-01	1.71e-02	1.55e-01
Diseases of hemostasis	13	4.46e-01	5.64e-01	0.22700	0.203000	-1.00e-01	2.04e-01	5.31e-01
Interleukin-23 signaling	7	4.45e-01	5.63e-01	0.22600	-0.023100	-2.25e-01	9.16e-01	3.02e-01
Biosynthesis of specialized proresolving mediators (SPMs)	15	3.40e-01	4.72e-01	0.22600	0.214000	-7.21e-02	1.50e-01	6.29e-01
SHC1 events in ERBB4 signaling	10	3.17e-01	4.50e-01	0.22600	0.225000	2.30e-02	2.19e-01	9.00e-01
Signaling by activated point mutants of FGFR1	5	6.52e-01	7.35e-01	0.22600	-0.039600	2.22e-01	8.78e-01	3.90e-01
Deadenylation-dependent mRNA decay	50	5.64e-04	3.39e-03	0.22600	-0.196000	-1.12e-01	1.67e-02	1.70e-01
Cargo trafficking to the periciliary membrane	48	8.67e-04	5.00e-03	0.22500	-0.104000	-2.00e-01	2.11e-01	1.68e-02
TGFBR3 expression	20	3.63e-01	4.95e-01	0.22500	0.146000	-1.71e-01	2.57e-01	1.86e-01
FGFR2c ligand binding and activation	5	7.70e-01	8.35e-01	0.22500	0.180000	-1.35e-01	4.86e-01	6.01e-01
RA biosynthesis pathway	13	2.96e-01	4.27e-01	0.22400	-0.224000	1.91e-02	1.63e-01	9.05e-01
Meiotic synapsis	43	4.70e-02	1.18e-01	0.22400	0.069600	-2.13e-01	4.30e-01	1.57e-02
Telomere Extension By Telomerase	23	1.98e-01	3.25e-01	0.22300	0.070500	-2.12e-01	5.58e-01	7.83e-02
FGFR2 mutant receptor activation	23	1.30e-01	2.47e-01	0.22300	-0.222000	2.84e-02	6.58e-02	8.14e-01
RUNX2 regulates bone development	21	3.54e-01	4.88e-01	0.22300	0.165000	-1.50e-01	1.89e-01	2.35e-01
Spry regulation of FGF signaling	16	3.56e-01	4.89e-01	0.22300	0.084400	-2.06e-01	5.59e-01	1.54e-01
Signaling by ERBB2 in Cancer	21	2.62e-01	3.91e-01	0.22300	0.205000	-8.65e-02	1.04e-01	4.92e-01
S Phase	150	3.40e-08	6.00e-07	0.22200	-0.032100	-2.20e-01	4.98e-01	3.41e-06
SUMOylation of immune response proteins	12	2.02e-01	3.30e-01	0.22200	0.074500	2.09e-01	6.55e-01	2.10e-01
Golgi Associated Vesicle Biogenesis	55	4.51e-02	1.15e-01	0.22200	0.108000	-1.94e-01	1.66e-01	1.29e-02
DNA Damage/Telomere Stress Induced Senescence	42	1.17e-01	2.27e-01	0.22200	0.131000	-1.79e-01	1.43e-01	4.45e-02
DNA Replication Pre-Initiation	103	1.96e-06	2.47e-05	0.22200	-0.062100	-2.13e-01	2.76e-01	1.88e-04
Ub-specific processing proteases	153	1.00e-05	1.08e-04	0.22200	0.054500	-2.15e-01	2.45e-01	4.43e-06
Extracellular matrix organization	213	1.28e-07	2.03e-06	0.22200	0.215000	-5.54e-02	6.75e-08	1.63e-01
Opioid Signalling	74	2.40e-02	7.14e-02	0.22200	0.177000	-1.33e-01	8.56e-03	4.71e-02
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	52	5.75e-02	1.36e-01	0.22100	-0.191000	1.12e-01	1.72e-02	1.62e-01
VEGF binds to VEGFR leading to receptor dimerization	5	5.78e-01	6.76e-01	0.22100	0.220000	2.13e-02	3.94e-01	9.34e-01
VEGF ligand-receptor interactions	5	5.78e-01	6.76e-01	0.22100	0.220000	2.13e-02	3.94e-01	9.34e-01
Biosynthesis of maresins	5	7.85e-01	8.47e-01	0.22100	0.161000	-1.51e-01	5.33e-01	5.58e-01
Class A/1 (Rhodopsin-like receptors)	176	5.09e-07	7.06e-06	0.22100	0.218000	-3.60e-02	6.20e-07	4.10e-01
Interleukin-1 family signaling	127	2.11e-03	1.08e-02	0.22100	0.144000	-1.67e-01	5.08e-03	1.14e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	2.17e-03	1.09e-02	0.22100	-0.168000	-1.43e-01	6.25e-02	1.13e-01
Diseases of DNA Double-Strand Break Repair	41	2.17e-03	1.09e-02	0.22100	-0.168000	-1.43e-01	6.25e-02	1.13e-01
Chondroitin sulfate biosynthesis	12	2.88e-01	4.19e-01	0.22100	0.220000	9.76e-03	1.86e-01	9.53e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.88e-01	5.14e-01	0.22100	0.185000	-1.20e-01	1.74e-01	3.79e-01
Cellular response to chemical stress	178	1.96e-04	1.40e-03	0.22000	0.147000	-1.64e-01	7.09e-04	1.61e-04
Deposition of new CENPA-containing nucleosomes at the centromere	37	1.67e-02	5.47e-02	0.22000	-0.025900	-2.19e-01	7.86e-01	2.14e-02
Nucleosome assembly	37	1.67e-02	5.47e-02	0.22000	-0.025900	-2.19e-01	7.86e-01	2.14e-02
Metabolism of steroids	120	2.64e-03	1.30e-02	0.22000	0.134000	-1.75e-01	1.15e-02	9.35e-04
Cell-Cell communication	108	5.44e-03	2.25e-02	0.22000	0.168000	-1.42e-01	2.60e-03	1.08e-02
Ion homeostasis	40	1.47e-01	2.68e-01	0.22000	0.162000	-1.48e-01	7.58e-02	1.05e-01
Rab regulation of trafficking	122	2.97e-03	1.39e-02	0.21900	0.147000	-1.63e-01	5.04e-03	1.88e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	2.45e-01	3.72e-01	0.21900	0.178000	-1.27e-01	1.02e-01	2.44e-01
SHC-mediated cascade:FGFR3	10	6.20e-01	7.11e-01	0.21900	0.146000	-1.63e-01	4.22e-01	3.72e-01
Programmed Cell Death	186	5.01e-07	7.03e-06	0.21900	0.042500	-2.15e-01	3.17e-01	4.36e-07
VEGFR2 mediated cell proliferation	18	4.25e-01	5.47e-01	0.21900	0.148000	-1.61e-01	2.76e-01	2.38e-01
Molybdenum cofactor biosynthesis	6	4.78e-01	5.91e-01	0.21800	-0.210000	-5.85e-02	3.72e-01	8.04e-01
Negative regulation of FLT3	15	4.85e-01	5.98e-01	0.21800	0.138000	-1.69e-01	3.54e-01	2.57e-01
RAF/MAP kinase cascade	222	3.13e-05	2.93e-04	0.21800	0.151000	-1.58e-01	1.07e-04	5.19e-05
Mitotic Spindle Checkpoint	107	7.62e-06	8.58e-05	0.21800	-0.029900	-2.16e-01	5.93e-01	1.13e-04
Creatine metabolism	7	7.13e-01	7.86e-01	0.21800	0.171000	-1.35e-01	4.34e-01	5.36e-01
RHO GTPases Activate Rhotekin and Rhophilins	8	5.72e-01	6.70e-01	0.21800	-0.209000	6.14e-02	3.06e-01	7.64e-01
Apoptosis	157	2.21e-06	2.76e-05	0.21800	0.029100	-2.16e-01	5.29e-01	3.08e-06
Signaling by NOTCH4	68	1.54e-02	5.18e-02	0.21700	0.082400	-2.01e-01	2.40e-01	4.15e-03
Pyruvate metabolism	44	4.14e-03	1.85e-02	0.21700	-0.066800	-2.06e-01	4.43e-01	1.79e-02
Thrombin signalling through proteinase activated receptors (PARs)	27	1.96e-01	3.22e-01	0.21700	0.200000	-8.41e-02	7.25e-02	4.50e-01
SARS-CoV-2-host interactions	181	3.99e-06	4.74e-05	0.21600	-0.208000	5.95e-02	1.45e-06	1.67e-01
Regulation of pyruvate metabolism	32	9.94e-02	2.03e-01	0.21600	0.051900	-2.10e-01	6.11e-01	4.02e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	3.96e-02	1.05e-01	0.21600	-0.212000	4.03e-02	1.75e-02	6.51e-01
HIV Transcription Elongation	42	3.96e-02	1.05e-01	0.21600	-0.212000	4.03e-02	1.75e-02	6.51e-01
Tat-mediated elongation of the HIV-1 transcript	42	3.96e-02	1.05e-01	0.21600	-0.212000	4.03e-02	1.75e-02	6.51e-01
Cell Cycle, Mitotic	487	1.12e-16	4.99e-15	0.21600	0.039800	-2.12e-01	1.33e-01	1.17e-15
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.18e-01	2.29e-01	0.21500	0.034000	-2.12e-01	7.60e-01	5.62e-02
SUMOylation of chromatin organization proteins	57	4.07e-02	1.06e-01	0.21500	-0.194000	9.29e-02	1.14e-02	2.25e-01
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	29	5.22e-02	1.27e-01	0.21500	0.214000	1.77e-02	4.62e-02	8.69e-01
M Phase	345	2.89e-12	7.93e-11	0.21400	0.035200	-2.12e-01	2.61e-01	1.45e-11
RSV-host interactions	76	1.04e-04	8.23e-04	0.21400	-0.063800	-2.04e-01	3.36e-01	2.05e-03
Asparagine N-linked glycosylation	284	1.40e-07	2.19e-06	0.21400	0.091600	-1.93e-01	7.91e-03	2.00e-08
TCR signaling	110	6.53e-05	5.38e-04	0.21400	0.012200	-2.14e-01	8.26e-01	1.08e-04
GRB2 events in ERBB2 signaling	11	2.38e-01	3.68e-01	0.21400	0.193000	9.20e-02	2.67e-01	5.97e-01
Pausing and recovery of Tat-mediated HIV elongation	30	1.37e-01	2.56e-01	0.21400	-0.204000	6.29e-02	5.27e-02	5.51e-01
Tat-mediated HIV elongation arrest and recovery	30	1.37e-01	2.56e-01	0.21400	-0.204000	6.29e-02	5.27e-02	5.51e-01
UCH proteinases	73	1.15e-02	4.20e-02	0.21400	0.076100	-2.00e-01	2.61e-01	3.16e-03
Homologous DNA Pairing and Strand Exchange	43	2.44e-03	1.21e-02	0.21300	-0.163000	-1.37e-01	6.38e-02	1.19e-01
Retrograde transport at the Trans-Golgi-Network	49	5.02e-03	2.12e-02	0.21300	-0.035800	-2.10e-01	6.65e-01	1.10e-02
Pyroptosis	24	8.59e-02	1.83e-01	0.21300	-0.022300	-2.12e-01	8.50e-01	7.26e-02
ISG15 antiviral mechanism	72	4.91e-05	4.27e-04	0.21300	-0.170000	-1.28e-01	1.27e-02	5.97e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	84	4.72e-03	2.04e-02	0.21300	0.202000	-6.68e-02	1.37e-03	2.90e-01
Meiotic recombination	36	2.12e-02	6.53e-02	0.21300	-0.033700	-2.10e-01	7.26e-01	2.92e-02
G alpha (s) signalling events	93	1.32e-02	4.60e-02	0.21200	0.171000	-1.27e-01	4.45e-03	3.49e-02
Hyaluronan uptake and degradation	12	2.37e-01	3.68e-01	0.21200	0.202000	6.58e-02	2.26e-01	6.93e-01
FGFR2 alternative splicing	25	2.42e-01	3.70e-01	0.21200	-0.194000	8.57e-02	9.31e-02	4.58e-01
Tryptophan catabolism	12	1.92e-01	3.19e-01	0.21200	-0.163000	-1.35e-01	3.28e-01	4.18e-01
Nuclear Receptor transcription pathway	38	5.30e-03	2.21e-02	0.21100	0.150000	1.49e-01	1.10e-01	1.12e-01
Defects in cobalamin (B12) metabolism	13	2.15e-01	3.42e-01	0.21100	-0.064900	-2.01e-01	6.85e-01	2.10e-01
Transcriptional Regulation by E2F6	34	9.37e-03	3.56e-02	0.21100	-0.151000	-1.47e-01	1.27e-01	1.38e-01
ABC transporters in lipid homeostasis	14	3.66e-01	4.97e-01	0.21100	-0.043600	2.06e-01	7.78e-01	1.81e-01
Metabolism of amine-derived hormones	10	2.55e-01	3.84e-01	0.21100	0.161000	1.36e-01	3.79e-01	4.56e-01
Methylation	13	3.72e-01	5.02e-01	0.21000	-0.208000	3.28e-02	1.94e-01	8.38e-01
DNA Replication	128	4.35e-07	6.19e-06	0.21000	-0.058000	-2.02e-01	2.57e-01	7.70e-05
Uptake and actions of bacterial toxins	27	2.06e-01	3.32e-01	0.21000	0.196000	-7.72e-02	7.83e-02	4.87e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	1.42e-02	4.87e-02	0.21000	0.207000	-3.49e-02	6.83e-03	6.49e-01
Glycogen breakdown (glycogenolysis)	12	5.92e-01	6.88e-01	0.21000	0.144000	-1.53e-01	3.89e-01	3.59e-01
MITF-M-dependent gene expression	81	2.90e-02	8.32e-02	0.21000	0.156000	-1.40e-01	1.52e-02	2.91e-02
Translation of Structural Proteins 9683701	29	1.12e-01	2.20e-01	0.21000	0.032700	-2.07e-01	7.61e-01	5.33e-02
RHOT2 GTPase cycle	7	6.98e-01	7.74e-01	0.21000	0.185000	-9.82e-02	3.96e-01	6.53e-01
Trafficking and processing of endosomal TLR	13	5.18e-01	6.28e-01	0.21000	0.101000	-1.83e-01	5.27e-01	2.52e-01
Activation of SMO	14	5.45e-01	6.49e-01	0.20900	0.146000	-1.50e-01	3.44e-01	3.31e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	1.35e-01	2.54e-01	0.20900	0.209000	1.38e-02	9.76e-02	9.13e-01
Loss of Function of TGFBR1 in Cancer	7	3.95e-01	5.19e-01	0.20900	-0.123000	-1.69e-01	5.74e-01	4.38e-01
Zinc influx into cells by the SLC39 gene family	9	6.16e-01	7.08e-01	0.20900	0.189000	-8.82e-02	3.26e-01	6.47e-01
Regulated proteolysis of p75NTR	11	4.66e-01	5.82e-01	0.20900	0.204000	-4.52e-02	2.42e-01	7.95e-01
G alpha (12/13) signalling events	68	3.28e-02	9.19e-02	0.20800	0.183000	-9.92e-02	8.98e-03	1.57e-01
Impaired BRCA2 binding to RAD51	35	1.08e-02	3.98e-02	0.20800	-0.111000	-1.76e-01	2.57e-01	7.10e-02
Sphingolipid de novo biosynthesis	34	1.65e-01	2.87e-01	0.20800	0.089200	-1.88e-01	3.68e-01	5.78e-02
Late endosomal microautophagy	30	2.31e-01	3.61e-01	0.20800	0.103000	-1.80e-01	3.27e-01	8.76e-02
Signaling by NOTCH	173	4.94e-04	3.04e-03	0.20800	0.126000	-1.65e-01	4.25e-03	1.78e-04
Ion transport by P-type ATPases	41	1.72e-01	2.98e-01	0.20800	0.154000	-1.39e-01	8.72e-02	1.24e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	4.67e-02	1.18e-01	0.20800	-0.178000	-1.07e-01	1.31e-01	3.65e-01
SHC1 events in ERBB2 signaling	17	2.66e-01	3.94e-01	0.20700	0.206000	-2.26e-02	1.41e-01	8.72e-01
Synthesis of DNA	108	1.45e-06	1.89e-05	0.20700	-0.097600	-1.83e-01	7.96e-02	1.04e-03
Signaling by Insulin receptor	63	3.62e-02	9.83e-02	0.20700	0.187000	-8.77e-02	1.01e-02	2.29e-01
Signaling by TGFB family members	137	2.70e-03	1.32e-02	0.20600	0.128000	-1.62e-01	9.76e-03	1.05e-03
Activation of the pre-replicative complex	32	1.57e-02	5.22e-02	0.20600	-0.162000	-1.27e-01	1.12e-01	2.14e-01
Activation of kainate receptors upon glutamate binding	25	3.36e-01	4.69e-01	0.20600	0.124000	-1.64e-01	2.82e-01	1.55e-01
SHC-mediated cascade:FGFR2	13	5.48e-01	6.52e-01	0.20600	0.109000	-1.74e-01	4.96e-01	2.77e-01
Ca-dependent events	29	2.46e-01	3.73e-01	0.20500	0.179000	-1.00e-01	9.45e-02	3.51e-01
Keratan sulfate degradation	9	4.99e-01	6.10e-01	0.20500	-0.020000	2.04e-01	9.17e-01	2.89e-01
Collagen chain trimerization	26	3.15e-01	4.50e-01	0.20500	0.169000	-1.17e-01	1.37e-01	3.03e-01
Synthesis of PIPs at the ER membrane	5	5.24e-01	6.32e-01	0.20500	-0.134000	-1.55e-01	6.04e-01	5.48e-01
Germ layer formation at gastrulation	9	4.96e-01	6.08e-01	0.20500	0.018000	-2.04e-01	9.26e-01	2.89e-01
Interleukin-18 signaling	6	7.38e-01	8.08e-01	0.20500	0.184000	-9.01e-02	4.36e-01	7.02e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	19	3.70e-01	5.02e-01	0.20400	0.186000	-8.39e-02	1.60e-01	5.27e-01
Trafficking of AMPA receptors	19	3.70e-01	5.02e-01	0.20400	0.186000	-8.39e-02	1.60e-01	5.27e-01
Chondroitin sulfate/dermatan sulfate metabolism	37	2.05e-02	6.35e-02	0.20400	0.048400	1.98e-01	6.10e-01	3.68e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	2.63e-01	3.91e-01	0.20300	-0.192000	-6.75e-02	2.50e-01	6.86e-01
Deadenylation of mRNA	22	6.18e-02	1.44e-01	0.20300	-0.127000	-1.58e-01	3.02e-01	1.98e-01
Calnexin/calreticulin cycle	26	2.15e-01	3.42e-01	0.20300	0.061700	-1.94e-01	5.86e-01	8.76e-02
PI3K events in ERBB2 signaling	11	2.54e-01	3.83e-01	0.20300	0.167000	1.16e-01	3.38e-01	5.07e-01
SHC-mediated cascade:FGFR4	11	6.38e-01	7.28e-01	0.20300	0.137000	-1.50e-01	4.31e-01	3.90e-01
Asymmetric localization of PCP proteins	49	4.11e-02	1.07e-01	0.20300	0.044300	-1.98e-01	5.92e-01	1.67e-02
Signaling by MST1	5	8.11e-01	8.66e-01	0.20200	-0.161000	1.22e-01	5.33e-01	6.37e-01
Oxidative Stress Induced Senescence	77	4.10e-02	1.07e-01	0.20200	0.124000	-1.59e-01	5.94e-02	1.58e-02
Glycosphingolipid transport	7	6.77e-01	7.57e-01	0.20200	-0.190000	6.84e-02	3.84e-01	7.54e-01
Coenzyme A biosynthesis	7	4.58e-01	5.73e-01	0.20200	-0.188000	-7.19e-02	3.88e-01	7.42e-01
Membrane binding and targetting of GAG proteins	13	2.15e-01	3.42e-01	0.20200	-0.094200	-1.78e-01	5.56e-01	2.66e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	2.15e-01	3.42e-01	0.20200	-0.094200	-1.78e-01	5.56e-01	2.66e-01
Downstream signaling of activated FGFR1	22	3.66e-01	4.97e-01	0.20100	0.174000	-1.01e-01	1.57e-01	4.12e-01
RAC1 GTPase cycle	170	1.60e-04	1.18e-03	0.20100	0.185000	-7.95e-02	3.17e-05	7.36e-02
Hedgehog ‘off’ state	91	6.36e-03	2.56e-02	0.20100	0.067100	-1.90e-01	2.69e-01	1.77e-03
Maturation of nucleoprotein 9683610	11	4.67e-01	5.83e-01	0.20100	0.031500	-1.98e-01	8.57e-01	2.54e-01
Activation of ATR in response to replication stress	37	1.02e-02	3.78e-02	0.20100	-0.138000	-1.45e-01	1.45e-01	1.27e-01
Diseases associated with surfactant metabolism	5	7.36e-01	8.07e-01	0.20000	0.194000	-5.10e-02	4.53e-01	8.44e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	4.58e-02	1.16e-01	0.20000	-0.198000	2.82e-02	2.27e-02	7.46e-01
Nef Mediated CD8 Down-regulation	7	7.09e-01	7.82e-01	0.20000	0.181000	-8.61e-02	4.07e-01	6.93e-01
PCP/CE pathway	74	3.18e-02	8.97e-02	0.20000	0.094700	-1.77e-01	1.59e-01	8.65e-03
Advanced glycosylation endproduct receptor signaling	12	3.58e-01	4.90e-01	0.20000	-0.009550	-2.00e-01	9.54e-01	2.31e-01
Transport of bile salts and organic acids, metal ions and amine compounds	51	5.58e-02	1.34e-01	0.19900	0.190000	-6.09e-02	1.91e-02	4.52e-01
Sphingolipid catabolism	11	4.37e-01	5.56e-01	0.19900	0.199000	-1.35e-02	2.54e-01	9.38e-01
FLT3 signaling by CBL mutants	7	6.15e-01	7.07e-01	0.19900	-0.197000	2.73e-02	3.67e-01	9.00e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	5.26e-01	6.35e-01	0.19900	0.069000	-1.86e-01	6.79e-01	2.64e-01
PPARA activates gene expression	105	1.70e-02	5.53e-02	0.19800	0.141000	-1.40e-01	1.27e-02	1.32e-02
RHO GTPase cycle	408	1.24e-07	1.99e-06	0.19800	0.154000	-1.25e-01	1.00e-07	1.50e-05
Defective B3GAT3 causes JDSSDHD	10	3.13e-01	4.48e-01	0.19800	0.170000	1.01e-01	3.52e-01	5.79e-01
Meiosis	66	4.85e-03	2.08e-02	0.19800	-0.003010	-1.98e-01	9.66e-01	5.49e-03
Signaling by FGFR4	32	2.66e-01	3.94e-01	0.19700	0.111000	-1.63e-01	2.77e-01	1.10e-01
Circadian Clock	67	8.30e-03	3.20e-02	0.19700	0.196000	-1.87e-02	5.43e-03	7.91e-01
Inhibition of DNA recombination at telomere	33	3.11e-02	8.83e-02	0.19700	-0.066400	-1.86e-01	5.09e-01	6.48e-02
Neurotoxicity of clostridium toxins	9	4.75e-01	5.89e-01	0.19700	0.008980	1.97e-01	9.63e-01	3.07e-01
G2/M DNA damage checkpoint	66	2.15e-02	6.60e-02	0.19700	0.051600	-1.90e-01	4.69e-01	7.69e-03
Chaperonin-mediated protein folding	77	3.81e-02	1.02e-01	0.19600	0.102000	-1.67e-01	1.21e-01	1.11e-02
Negative regulation of the PI3K/AKT network	91	5.55e-03	2.28e-02	0.19600	0.189000	-5.36e-02	1.86e-03	3.77e-01
Glycerophospholipid catabolism	6	7.71e-01	8.35e-01	0.19600	-0.170000	9.85e-02	4.72e-01	6.76e-01
CRMPs in Sema3A signaling	13	5.65e-01	6.65e-01	0.19600	0.171000	-9.64e-02	2.86e-01	5.47e-01
IKK complex recruitment mediated by RIP1	23	2.53e-01	3.82e-01	0.19600	0.046200	-1.90e-01	7.01e-01	1.14e-01
Platelet Aggregation (Plug Formation)	28	2.42e-01	3.70e-01	0.19600	0.182000	-7.23e-02	9.53e-02	5.08e-01
RHOH GTPase cycle	33	2.38e-01	3.68e-01	0.19600	0.096600	-1.70e-01	3.37e-01	9.10e-02
HIV Transcription Initiation	45	5.06e-03	2.12e-02	0.19600	-0.128000	-1.48e-01	1.38e-01	8.59e-02
RNA Polymerase II HIV Promoter Escape	45	5.06e-03	2.12e-02	0.19600	-0.128000	-1.48e-01	1.38e-01	8.59e-02
RNA Polymerase II Promoter Escape	45	5.06e-03	2.12e-02	0.19600	-0.128000	-1.48e-01	1.38e-01	8.59e-02
RNA Polymerase II Transcription Initiation	45	5.06e-03	2.12e-02	0.19600	-0.128000	-1.48e-01	1.38e-01	8.59e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	5.06e-03	2.12e-02	0.19600	-0.128000	-1.48e-01	1.38e-01	8.59e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	5.06e-03	2.12e-02	0.19600	-0.128000	-1.48e-01	1.38e-01	8.59e-02
Cell Cycle	609	1.48e-19	7.72e-18	0.19500	0.011800	-1.95e-01	6.19e-01	1.93e-16
mRNA Capping	29	9.11e-02	1.91e-01	0.19500	-0.195000	-1.21e-02	6.93e-02	9.10e-01
Downstream TCR signaling	89	3.58e-04	2.38e-03	0.19500	-0.029100	-1.93e-01	6.36e-01	1.65e-03
Alpha-protein kinase 1 signaling pathway	11	5.39e-01	6.45e-01	0.19500	0.054500	-1.87e-01	7.54e-01	2.82e-01
Signaling by TGF-beta Receptor Complex	90	2.65e-02	7.72e-02	0.19500	0.109000	-1.62e-01	7.38e-02	8.09e-03
Noncanonical activation of NOTCH3	8	5.84e-01	6.80e-01	0.19500	0.024900	-1.93e-01	9.03e-01	3.44e-01
Non-integrin membrane-ECM interactions	46	6.89e-03	2.74e-02	0.19400	0.174000	8.61e-02	4.11e-02	3.12e-01
Downregulation of ERBB2 signaling	24	3.93e-01	5.18e-01	0.19400	-0.115000	1.56e-01	3.31e-01	1.86e-01
Extension of Telomeres	51	8.75e-03	3.35e-02	0.19400	-0.189000	-4.19e-02	1.95e-02	6.04e-01
G alpha (q) signalling events	139	1.51e-03	8.15e-03	0.19300	0.177000	-7.92e-02	3.26e-04	1.07e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6	5.16e-01	6.26e-01	0.19300	-0.168000	-9.56e-02	4.76e-01	6.85e-01
TGFBR1 KD Mutants in Cancer	6	5.16e-01	6.26e-01	0.19300	-0.168000	-9.56e-02	4.76e-01	6.85e-01
Immune System	1828	7.64e-31	1.47e-28	0.19300	0.101000	-1.65e-01	9.28e-13	1.22e-31
Diseases of signal transduction by growth factor receptors and second messengers	399	4.25e-07	6.13e-06	0.19300	0.125000	-1.47e-01	1.88e-05	4.41e-07
Signaling by ERBB2 KD Mutants	20	3.37e-01	4.70e-01	0.19300	0.185000	-5.51e-02	1.53e-01	6.70e-01
RUNX3 Regulates Immune Response and Cell Migration	5	7.96e-01	8.57e-01	0.19200	0.081600	-1.74e-01	7.52e-01	5.00e-01
Regulated Necrosis	55	1.73e-02	5.61e-02	0.19200	0.003870	-1.92e-01	9.60e-01	1.36e-02
Phenylalanine and tyrosine metabolism	9	5.68e-01	6.67e-01	0.19200	-0.190000	3.13e-02	3.25e-01	8.71e-01
NrCAM interactions	6	7.97e-01	8.58e-01	0.19200	-0.153000	1.16e-01	5.18e-01	6.22e-01
HIV elongation arrest and recovery	32	1.60e-01	2.84e-01	0.19200	-0.186000	4.48e-02	6.82e-02	6.61e-01
Pausing and recovery of HIV elongation	32	1.60e-01	2.84e-01	0.19200	-0.186000	4.48e-02	6.82e-02	6.61e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	10	3.49e-01	4.84e-01	0.19100	0.171000	8.49e-02	3.48e-01	6.42e-01
G beta:gamma signalling through PLC beta	17	5.35e-01	6.42e-01	0.19100	0.122000	-1.47e-01	3.84e-01	2.94e-01
Presynaptic function of Kainate receptors	17	5.35e-01	6.42e-01	0.19100	0.122000	-1.47e-01	3.84e-01	2.94e-01
Peroxisomal protein import	58	2.44e-03	1.21e-02	0.19100	-0.172000	-8.19e-02	2.32e-02	2.81e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	15	3.91e-01	5.17e-01	0.19100	0.188000	-2.90e-02	2.07e-01	8.46e-01
Signaling by Hedgehog	120	4.11e-03	1.84e-02	0.19000	0.075900	-1.74e-01	1.51e-01	9.64e-04
Signaling by BMP	23	4.31e-01	5.51e-01	0.19000	0.119000	-1.48e-01	3.21e-01	2.20e-01
tRNA Aminoacylation	42	3.31e-02	9.23e-02	0.19000	-0.189000	-1.91e-02	3.39e-02	8.31e-01
Lipophagy	7	5.14e-01	6.25e-01	0.19000	-0.056400	-1.81e-01	7.96e-01	4.06e-01
Processing of Intronless Pre-mRNAs	20	2.40e-01	3.69e-01	0.19000	-0.190000	5.04e-03	1.42e-01	9.69e-01
GPCR ligand binding	241	4.51e-07	6.37e-06	0.19000	0.187000	-3.07e-02	5.64e-07	4.12e-01
Ribavirin ADME	11	6.39e-01	7.29e-01	0.19000	0.094400	-1.64e-01	5.88e-01	3.45e-01
Extra-nuclear estrogen signaling	65	7.63e-02	1.67e-01	0.18900	0.162000	-9.86e-02	2.41e-02	1.69e-01
HDL assembly	6	6.43e-01	7.30e-01	0.18900	0.189000	1.40e-03	4.22e-01	9.95e-01
FGFR2 ligand binding and activation	9	6.47e-01	7.34e-01	0.18900	-0.177000	6.65e-02	3.57e-01	7.30e-01
Bile acid and bile salt metabolism	28	2.89e-01	4.20e-01	0.18900	0.079400	-1.72e-01	4.67e-01	1.16e-01
Interleukin-1 signaling	99	2.59e-02	7.58e-02	0.18900	0.113000	-1.52e-01	5.28e-02	8.94e-03
Lysine catabolism	10	7.02e-01	7.78e-01	0.18900	0.132000	-1.35e-01	4.70e-01	4.59e-01
Neurotransmitter receptors and postsynaptic signal transmission	132	6.66e-03	2.66e-02	0.18900	0.157000	-1.05e-01	1.83e-03	3.76e-02
Signaling by FGFR2 IIIa TM	18	2.26e-01	3.55e-01	0.18900	-0.187000	-2.54e-02	1.69e-01	8.52e-01
ERBB2 Regulates Cell Motility	10	4.87e-01	5.99e-01	0.18900	-0.001390	1.89e-01	9.94e-01	3.02e-01
C-type lectin receptors (CLRs)	116	3.74e-03	1.71e-02	0.18800	0.063700	-1.77e-01	2.36e-01	1.00e-03
Maternal to zygotic transition (MZT)	71	8.36e-02	1.79e-01	0.18800	0.127000	-1.38e-01	6.43e-02	4.38e-02
The NLRP3 inflammasome	16	3.05e-01	4.39e-01	0.18700	0.007220	1.87e-01	9.60e-01	1.95e-01
Regulation of NF-kappa B signaling	18	2.57e-01	3.85e-01	0.18700	-0.186000	-1.14e-02	1.71e-01	9.33e-01
tRNA processing in the mitochondrion	24	4.38e-01	5.56e-01	0.18600	-0.131000	1.33e-01	2.68e-01	2.59e-01
Deubiquitination	225	1.59e-04	1.18e-03	0.18600	0.092700	-1.61e-01	1.66e-02	3.02e-05
Adaptive Immune System	765	1.12e-16	4.99e-15	0.18600	0.056100	-1.77e-01	8.33e-03	6.83e-17
HDR through MMEJ (alt-NHEJ)	12	2.82e-01	4.13e-01	0.18600	-0.115000	-1.46e-01	4.92e-01	3.81e-01
RHOQ GTPase cycle	54	6.64e-02	1.52e-01	0.18500	0.178000	-5.27e-02	2.40e-02	5.03e-01
Receptor-type tyrosine-protein phosphatases	11	3.58e-01	4.90e-01	0.18500	0.065500	1.73e-01	7.07e-01	3.21e-01
Toll-like Receptor Cascades	162	3.89e-03	1.76e-02	0.18500	0.117000	-1.43e-01	1.01e-02	1.70e-03
AURKA Activation by TPX2	72	3.19e-02	8.98e-02	0.18500	0.058500	-1.75e-01	3.91e-01	1.02e-02
Loss of MECP2 binding ability to the NCoR/SMRT complex	7	7.80e-01	8.44e-01	0.18500	0.150000	-1.08e-01	4.93e-01	6.21e-01
O-linked glycosylation	81	9.95e-03	3.74e-02	0.18400	0.182000	-3.23e-02	4.71e-03	6.16e-01
Synthesis of 12-eicosatetraenoic acid derivatives	6	8.17e-01	8.70e-01	0.18400	-0.134000	1.26e-01	5.69e-01	5.92e-01
CLEC7A (Dectin-1) signaling	85	1.19e-02	4.30e-02	0.18400	0.045000	-1.79e-01	4.74e-01	4.41e-03
Signaling by NOTCH3	42	1.43e-01	2.64e-01	0.18400	0.173000	-6.27e-02	5.21e-02	4.82e-01
G alpha (i) signalling events	196	1.47e-04	1.10e-03	0.18400	0.172000	-6.58e-02	3.30e-05	1.12e-01
O-glycosylation of TSR domain-containing proteins	25	2.15e-01	3.42e-01	0.18400	-0.019400	1.83e-01	8.66e-01	1.13e-01
Defective B4GALT7 causes EDS, progeroid type	10	3.53e-01	4.88e-01	0.18400	0.135000	1.25e-01	4.60e-01	4.94e-01
Nonhomologous End-Joining (NHEJ)	40	8.73e-02	1.86e-01	0.18300	0.019800	-1.82e-01	8.28e-01	4.60e-02
RAC3 GTPase cycle	86	4.91e-02	1.21e-01	0.18200	0.150000	-1.03e-01	1.61e-02	9.74e-02
DAP12 interactions	39	2.78e-01	4.08e-01	0.18200	0.125000	-1.32e-01	1.76e-01	1.53e-01
Protein folding	83	3.38e-02	9.32e-02	0.18200	0.077000	-1.65e-01	2.25e-01	9.35e-03
Toll Like Receptor 4 (TLR4) Cascade	138	1.13e-02	4.13e-02	0.18200	0.129000	-1.27e-01	8.67e-03	9.73e-03
Elastic fibre formation	33	9.08e-02	1.91e-01	0.18100	0.181000	1.51e-02	7.24e-02	8.81e-01
MHC class II antigen presentation	113	2.21e-02	6.76e-02	0.18100	0.109000	-1.45e-01	4.56e-02	7.78e-03
Attachment of GPI anchor to uPAR	7	7.93e-01	8.54e-01	0.18100	0.141000	-1.13e-01	5.18e-01	6.03e-01
PI3K/AKT Signaling in Cancer	83	1.37e-03	7.43e-03	0.18000	0.177000	3.57e-02	5.33e-03	5.74e-01
CDH11 homotypic and heterotypic interactions	5	6.41e-01	7.30e-01	0.18000	0.063100	1.69e-01	8.07e-01	5.13e-01
Sensory Perception	188	1.89e-05	1.90e-04	0.18000	0.179000	-2.12e-02	2.30e-05	6.16e-01
Myoclonic epilepsy of Lafora	8	4.67e-01	5.83e-01	0.18000	-0.157000	-8.79e-02	4.42e-01	6.67e-01
Activation of RAC1 downstream of NMDARs	7	6.52e-01	7.35e-01	0.18000	0.180000	-1.32e-02	4.11e-01	9.52e-01
Syndecan interactions	23	1.34e-01	2.52e-01	0.18000	0.169000	6.05e-02	1.60e-01	6.15e-01
MicroRNA (miRNA) biogenesis	24	3.18e-01	4.50e-01	0.18000	-0.173000	4.94e-02	1.43e-01	6.75e-01
Chromosome Maintenance	102	4.69e-05	4.12e-04	0.17900	-0.143000	-1.08e-01	1.23e-02	6.00e-02
Antiviral mechanism by IFN-stimulated genes	140	4.10e-06	4.83e-05	0.17900	-0.067300	-1.66e-01	1.69e-01	6.85e-04
Regulation of PLK1 Activity at G2/M Transition	87	6.59e-03	2.64e-02	0.17900	0.020000	-1.78e-01	7.47e-01	4.12e-03
TP53 Regulates Transcription of Cell Cycle Genes	47	2.12e-01	3.40e-01	0.17900	0.143000	-1.08e-01	9.00e-02	2.01e-01
DCC mediated attractive signaling	13	6.60e-01	7.43e-01	0.17900	0.119000	-1.34e-01	4.56e-01	4.05e-01
Regulation of lipid metabolism by PPARalpha	107	3.42e-02	9.39e-02	0.17900	0.128000	-1.26e-01	2.27e-02	2.49e-02
Signaling by Nuclear Receptors	210	1.34e-03	7.33e-03	0.17900	0.133000	-1.20e-01	9.10e-04	2.83e-03
Class B/2 (Secretin family receptors)	54	1.58e-01	2.83e-01	0.17900	0.149000	-9.84e-02	5.82e-02	2.11e-01
RIP-mediated NFkB activation via ZBP1	17	2.65e-01	3.94e-01	0.17900	0.175000	3.56e-02	2.12e-01	7.99e-01
RIPK1-mediated regulated necrosis	31	1.76e-01	3.02e-01	0.17800	0.024100	-1.77e-01	8.16e-01	8.84e-02
Regulation of necroptotic cell death	31	1.76e-01	3.02e-01	0.17800	0.024100	-1.77e-01	8.16e-01	8.84e-02
CDC42 GTPase cycle	139	1.97e-04	1.41e-03	0.17700	0.177000	-6.75e-03	3.06e-04	8.91e-01
Vitamin B5 (pantothenate) metabolism	20	4.92e-01	6.04e-01	0.17700	0.089200	-1.53e-01	4.90e-01	2.35e-01
HSF1-dependent transactivation	28	1.31e-01	2.47e-01	0.17700	0.175000	2.37e-02	1.08e-01	8.28e-01
Cleavage of the damaged pyrimidine	26	1.63e-01	2.87e-01	0.17700	-0.015600	-1.76e-01	8.91e-01	1.20e-01
Depyrimidination	26	1.63e-01	2.87e-01	0.17700	-0.015600	-1.76e-01	8.91e-01	1.20e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	26	1.63e-01	2.87e-01	0.17700	-0.015600	-1.76e-01	8.91e-01	1.20e-01
Signal Transduction	2034	5.53e-27	5.59e-25	0.17700	0.144000	-1.03e-01	8.53e-27	2.49e-14
Paradoxical activation of RAF signaling by kinase inactive BRAF	40	2.84e-01	4.14e-01	0.17700	0.112000	-1.36e-01	2.18e-01	1.36e-01
Signaling by RAS mutants	40	2.84e-01	4.14e-01	0.17700	0.112000	-1.36e-01	2.18e-01	1.36e-01
Signaling by moderate kinase activity BRAF mutants	40	2.84e-01	4.14e-01	0.17700	0.112000	-1.36e-01	2.18e-01	1.36e-01
Signaling downstream of RAS mutants	40	2.84e-01	4.14e-01	0.17700	0.112000	-1.36e-01	2.18e-01	1.36e-01
Receptor Mediated Mitophagy	11	5.55e-01	6.57e-01	0.17600	0.026300	-1.74e-01	8.80e-01	3.18e-01
PI5P Regulates TP53 Acetylation	8	4.69e-01	5.85e-01	0.17500	0.131000	1.17e-01	5.22e-01	5.67e-01
Suppression of phagosomal maturation	12	3.51e-01	4.86e-01	0.17500	-0.073500	-1.59e-01	6.60e-01	3.40e-01
Signaling by Receptor Tyrosine Kinases	443	2.36e-07	3.55e-06	0.17400	0.153000	-8.37e-02	3.38e-08	2.54e-03
Phosphorylation of the APC/C	20	1.58e-01	2.83e-01	0.17400	-0.140000	-1.03e-01	2.77e-01	4.25e-01
Bacterial Infection Pathways	65	1.43e-01	2.65e-01	0.17400	0.124000	-1.22e-01	8.47e-02	8.79e-02
Interconversion of nucleotide di- and triphosphates	27	8.42e-02	1.80e-01	0.17400	-0.141000	-1.01e-01	2.04e-01	3.62e-01
Nicotinate metabolism	26	3.24e-01	4.57e-01	0.17400	0.052300	-1.66e-01	6.44e-01	1.43e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	4.31e-01	5.50e-01	0.17300	0.086700	-1.50e-01	4.53e-01	1.96e-01
Deactivation of the beta-catenin transactivating complex	36	2.28e-01	3.58e-01	0.17200	0.056800	-1.63e-01	5.56e-01	9.13e-02
Cell recruitment (pro-inflammatory response)	25	1.87e-01	3.13e-01	0.17200	0.019100	1.71e-01	8.69e-01	1.39e-01
Purinergic signaling in leishmaniasis infection	25	1.87e-01	3.13e-01	0.17200	0.019100	1.71e-01	8.69e-01	1.39e-01
Response of Mtb to phagocytosis	22	4.54e-01	5.69e-01	0.17200	0.074900	-1.55e-01	5.43e-01	2.09e-01
Glycogen metabolism	21	3.78e-01	5.05e-01	0.17200	0.039000	-1.67e-01	7.57e-01	1.85e-01
Ion channel transport	136	5.45e-03	2.25e-02	0.17100	0.159000	-6.37e-02	1.37e-03	2.00e-01
Defective RIPK1-mediated regulated necrosis	7	5.63e-01	6.63e-01	0.17100	-0.157000	-6.75e-02	4.71e-01	7.57e-01
Surfactant metabolism	20	5.62e-01	6.63e-01	0.17100	0.121000	-1.21e-01	3.49e-01	3.50e-01
HDR through Homologous Recombination (HRR)	68	3.88e-03	1.76e-02	0.17100	-0.157000	-6.81e-02	2.56e-02	3.31e-01
Transcriptional regulation by RUNX2	87	3.74e-02	1.00e-01	0.17000	0.064100	-1.58e-01	3.02e-01	1.10e-02
Negative regulation of FGFR2 signaling	24	3.96e-01	5.20e-01	0.17000	0.061200	-1.59e-01	6.04e-01	1.79e-01
Activation of BH3-only proteins	29	4.28e-01	5.48e-01	0.17000	-0.106000	1.33e-01	3.25e-01	2.15e-01
Epigenetic regulation by WDR5-containing histone modifying complexes	117	3.32e-02	9.24e-02	0.16900	0.104000	-1.33e-01	5.18e-02	1.27e-02
Infection with Mycobacterium tuberculosis	26	3.83e-01	5.08e-01	0.16900	0.064300	-1.56e-01	5.70e-01	1.69e-01
Metabolism of cofactors	25	2.91e-01	4.22e-01	0.16900	-0.167000	2.45e-02	1.49e-01	8.32e-01
ZBP1(DAI) mediated induction of type I IFNs	20	2.52e-01	3.81e-01	0.16800	0.165000	3.19e-02	2.00e-01	8.05e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	41	1.75e-01	3.01e-01	0.16800	0.044700	-1.62e-01	6.21e-01	7.20e-02
HDR through Single Strand Annealing (SSA)	37	3.93e-02	1.04e-01	0.16800	-0.121000	-1.17e-01	2.04e-01	2.16e-01
Regulation of TP53 Activity through Acetylation	29	3.44e-01	4.78e-01	0.16800	-0.063900	1.56e-01	5.51e-01	1.47e-01
G beta:gamma signalling through PI3Kgamma	22	5.40e-01	6.45e-01	0.16800	0.114000	-1.24e-01	3.55e-01	3.16e-01
Interferon Signaling	237	7.39e-09	1.38e-07	0.16700	-0.071100	-1.52e-01	5.95e-02	5.82e-05
Negative regulation of FGFR3 signaling	21	4.87e-01	5.99e-01	0.16700	0.072200	-1.51e-01	5.67e-01	2.31e-01
Diseases of carbohydrate metabolism	29	4.48e-01	5.64e-01	0.16700	-0.119000	1.17e-01	2.66e-01	2.74e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	1.41e-01	2.62e-01	0.16700	0.002810	-1.67e-01	9.77e-01	8.72e-02
Regulation of localization of FOXO transcription factors	11	4.13e-01	5.36e-01	0.16700	0.076200	1.48e-01	6.62e-01	3.95e-01
G-protein mediated events	43	1.80e-01	3.05e-01	0.16700	0.159000	-4.99e-02	7.12e-02	5.71e-01
Heme signaling	45	1.39e-01	2.58e-01	0.16700	0.162000	-3.72e-02	5.96e-02	6.66e-01
IRE1alpha activates chaperones	46	1.59e-01	2.84e-01	0.16600	0.159000	-4.92e-02	6.21e-02	5.64e-01
The canonical retinoid cycle in rods (twilight vision)	9	5.27e-01	6.35e-01	0.16600	0.045100	1.60e-01	8.15e-01	4.07e-01
SARS-CoV-1 Infection	137	2.17e-05	2.11e-04	0.16500	-0.147000	-7.53e-02	2.98e-03	1.28e-01
Transport of vitamins, nucleosides, and related molecules	31	4.22e-01	5.44e-01	0.16500	-0.130000	1.01e-01	2.09e-01	3.29e-01
GPCR downstream signalling	396	5.28e-07	7.25e-06	0.16500	0.155000	-5.64e-02	1.19e-07	5.43e-02
Signaling by NTRKs	116	2.70e-02	7.83e-02	0.16500	0.144000	-7.96e-02	7.26e-03	1.39e-01
PI Metabolism	79	1.21e-01	2.33e-01	0.16500	0.114000	-1.18e-01	7.86e-02	6.88e-02
Signaling by ERBB4	45	2.57e-01	3.85e-01	0.16500	0.141000	-8.41e-02	1.01e-01	3.29e-01
Aggrephagy	34	3.96e-01	5.20e-01	0.16400	0.105000	-1.27e-01	2.89e-01	2.02e-01
Stimuli-sensing channels	78	2.70e-02	7.83e-02	0.16400	0.162000	-2.55e-02	1.31e-02	6.97e-01
TP53 Regulates Transcription of DNA Repair Genes	61	2.02e-02	6.33e-02	0.16400	-0.162000	-2.71e-02	2.89e-02	7.14e-01
Oncogene Induced Senescence	33	3.85e-01	5.11e-01	0.16400	0.089900	-1.37e-01	3.72e-01	1.73e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9	6.51e-01	7.35e-01	0.16400	-0.020500	1.63e-01	9.15e-01	3.98e-01
DNA Repair	288	1.12e-09	2.36e-08	0.16400	-0.155000	-5.45e-02	6.40e-06	1.12e-01
Transcriptional regulation of white adipocyte differentiation	77	1.11e-01	2.18e-01	0.16400	0.136000	-9.11e-02	3.89e-02	1.67e-01
Glycosphingolipid catabolism	31	4.17e-01	5.39e-01	0.16400	-0.134000	9.35e-02	1.95e-01	3.68e-01
Cytokine Signaling in Immune system	662	1.11e-08	2.00e-07	0.16400	0.091300	-1.36e-01	6.18e-05	2.64e-09
Ephrin signaling	17	3.75e-01	5.04e-01	0.16300	-0.009490	-1.63e-01	9.46e-01	2.44e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	5.79e-01	6.77e-01	0.16300	0.159000	-3.71e-02	3.21e-01	8.17e-01
PRC2 methylates histones and DNA	27	3.08e-01	4.44e-01	0.16300	0.031400	-1.60e-01	7.78e-01	1.50e-01
NR1H2 and NR1H3-mediated signaling	38	1.39e-01	2.58e-01	0.16300	0.163000	-6.20e-03	8.24e-02	9.47e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	1.43e-01	2.64e-01	0.16300	-0.153000	-5.61e-02	1.69e-01	6.14e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.43e-01	2.64e-01	0.16300	-0.153000	-5.61e-02	1.69e-01	6.14e-01
Signaling by GPCR	441	3.40e-08	6.00e-07	0.16300	0.157000	-4.33e-02	1.61e-08	1.20e-01
Striated Muscle Contraction	25	4.96e-01	6.08e-01	0.16100	0.135000	-8.81e-02	2.42e-01	4.46e-01
Negative regulation of FGFR4 signaling	22	5.01e-01	6.11e-01	0.16100	0.070800	-1.45e-01	5.65e-01	2.40e-01
Clathrin-mediated endocytosis	127	3.67e-02	9.89e-02	0.16100	0.102000	-1.25e-01	4.72e-02	1.54e-02
Downregulation of TGF-beta receptor signaling	26	4.38e-01	5.56e-01	0.16100	0.068700	-1.45e-01	5.44e-01	1.99e-01
IL-6-type cytokine receptor ligand interactions	12	4.33e-01	5.52e-01	0.16100	0.054100	1.51e-01	7.46e-01	3.64e-01
TNFR2 non-canonical NF-kB pathway	84	1.17e-02	4.26e-02	0.16100	-0.001540	-1.61e-01	9.80e-01	1.10e-02
HIV Life Cycle	144	1.06e-04	8.34e-04	0.16000	-0.156000	-3.51e-02	1.20e-03	4.67e-01
Class I MHC mediated antigen processing & presentation	343	2.97e-09	5.88e-08	0.16000	-0.017400	-1.59e-01	5.80e-01	4.06e-07
Telomere Maintenance	78	2.66e-03	1.30e-02	0.16000	-0.137000	-8.35e-02	3.70e-02	2.02e-01
Synthesis of pyrophosphates in the cytosol	8	5.73e-01	6.71e-01	0.16000	-0.150000	-5.51e-02	4.62e-01	7.87e-01
Bicarbonate transporters	9	5.70e-01	6.68e-01	0.16000	-0.031500	-1.57e-01	8.70e-01	4.16e-01
LGI-ADAM interactions	9	6.88e-01	7.68e-01	0.16000	-0.032100	1.57e-01	8.68e-01	4.16e-01
Integrin signaling	22	5.53e-01	6.55e-01	0.16000	0.131000	-9.10e-02	2.86e-01	4.60e-01
MET activates PTK2 signaling	21	5.43e-01	6.48e-01	0.16000	0.139000	-7.83e-02	2.70e-01	5.35e-01
Azathioprine ADME	20	4.42e-01	5.60e-01	0.15900	0.033600	-1.56e-01	7.95e-01	2.28e-01
Aryl hydrocarbon receptor signalling	6	7.44e-01	8.13e-01	0.15900	-0.159000	7.20e-03	5.00e-01	9.76e-01
Signaling by ERBB2 TMD/JMD mutants	17	4.37e-01	5.56e-01	0.15900	0.159000	-8.58e-03	2.57e-01	9.51e-01
CaM pathway	27	4.51e-01	5.66e-01	0.15900	0.140000	-7.37e-02	2.07e-01	5.07e-01
Calmodulin induced events	27	4.51e-01	5.66e-01	0.15900	0.140000	-7.37e-02	2.07e-01	5.07e-01
Defective pyroptosis	27	2.23e-01	3.52e-01	0.15800	-0.014200	-1.57e-01	8.98e-01	1.57e-01
Cytochrome P450 - arranged by substrate type	33	2.62e-01	3.91e-01	0.15800	0.155000	-3.17e-02	1.24e-01	7.52e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	9	7.99e-01	8.59e-01	0.15800	0.120000	-1.03e-01	5.34e-01	5.92e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	7	6.65e-01	7.46e-01	0.15800	-0.023000	-1.56e-01	9.16e-01	4.74e-01
Processing of DNA double-strand break ends	69	3.63e-02	9.84e-02	0.15800	0.007810	-1.58e-01	9.11e-01	2.36e-02
Response of EIF2AK1 (HRI) to heme deficiency	14	7.07e-01	7.81e-01	0.15800	0.118000	-1.05e-01	4.45e-01	4.98e-01
Nuclear Pore Complex (NPC) Disassembly	36	2.55e-01	3.84e-01	0.15800	-0.153000	3.96e-02	1.13e-01	6.81e-01
Androgen biosynthesis	5	8.31e-01	8.81e-01	0.15800	0.043100	-1.52e-01	8.67e-01	5.57e-01
RAS processing	23	2.65e-01	3.94e-01	0.15700	-0.022100	-1.56e-01	8.54e-01	1.96e-01
trans-Golgi Network Vesicle Budding	69	1.21e-01	2.34e-01	0.15700	0.066000	-1.43e-01	3.43e-01	4.04e-02
SUMOylation of DNA damage response and repair proteins	77	2.84e-02	8.18e-02	0.15600	-0.156000	1.04e-02	1.80e-02	8.75e-01
Diseases associated with N-glycosylation of proteins	20	5.64e-01	6.64e-01	0.15600	-0.138000	7.28e-02	2.85e-01	5.73e-01
Serotonin Neurotransmitter Release Cycle	15	3.97e-01	5.21e-01	0.15500	0.150000	3.90e-02	3.13e-01	7.94e-01
Other interleukin signaling	18	6.40e-01	7.29e-01	0.15500	0.091700	-1.24e-01	5.01e-01	3.61e-01
Host Interactions of HIV factors	118	1.77e-04	1.29e-03	0.15500	-0.117000	-1.01e-01	2.80e-02	5.83e-02
HIV Infection	213	1.85e-07	2.83e-06	0.15500	-0.100000	-1.18e-01	1.18e-02	3.09e-03
Cytoprotection by HMOX1	53	2.02e-01	3.30e-01	0.15400	0.141000	-6.18e-02	7.49e-02	4.37e-01
Defective B3GALTL causes PpS	24	2.95e-01	4.27e-01	0.15400	0.007810	1.54e-01	9.47e-01	1.92e-01
Transcription of the HIV genome	67	1.04e-02	3.84e-02	0.15300	-0.136000	-7.14e-02	5.46e-02	3.12e-01
ER Quality Control Compartment (ERQC)	21	3.62e-01	4.93e-01	0.15300	-0.001390	-1.53e-01	9.91e-01	2.24e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	4.20e-01	5.43e-01	0.15300	0.055700	-1.42e-01	6.10e-01	1.92e-01
Formation of the Editosome	6	7.51e-01	8.17e-01	0.15300	0.153000	3.45e-04	5.17e-01	9.99e-01
mRNA Editing: C to U Conversion	6	7.51e-01	8.17e-01	0.15300	0.153000	3.45e-04	5.17e-01	9.99e-01
Dermatan sulfate biosynthesis	6	6.50e-01	7.35e-01	0.15300	0.117000	9.85e-02	6.21e-01	6.76e-01
PERK regulates gene expression	30	2.33e-01	3.63e-01	0.15300	-0.153000	-3.41e-03	1.48e-01	9.74e-01
PLC beta mediated events	39	2.16e-01	3.43e-01	0.15200	0.150000	-2.54e-02	1.04e-01	7.83e-01
Sensing of DNA Double Strand Breaks	6	6.51e-01	7.35e-01	0.15200	-0.112000	-1.03e-01	6.36e-01	6.61e-01
FASTK family proteins regulate processing and stability of mitochondrial RNAs	19	5.18e-01	6.28e-01	0.15200	-0.040300	1.46e-01	7.61e-01	2.69e-01
Signaling by NTRK1 (TRKA)	102	7.20e-02	1.61e-01	0.15200	0.131000	-7.64e-02	2.22e-02	1.83e-01
NCAM1 interactions	26	4.22e-01	5.44e-01	0.15000	-0.042400	1.44e-01	7.08e-01	2.03e-01
Peroxisomal lipid metabolism	27	1.78e-01	3.02e-01	0.15000	-0.135000	-6.44e-02	2.24e-01	5.63e-01
NRAGE signals death through JNK	52	1.26e-01	2.41e-01	0.15000	0.148000	-1.85e-02	6.40e-02	8.17e-01
TBC/RABGAPs	45	3.67e-01	4.98e-01	0.15000	0.112000	-9.88e-02	1.92e-01	2.51e-01
IFNG signaling activates MAPKs	8	8.21e-01	8.72e-01	0.14900	0.078100	-1.27e-01	7.02e-01	5.33e-01
Toll Like Receptor 2 (TLR2) Cascade	109	9.08e-02	1.91e-01	0.14900	0.109000	-1.02e-01	4.94e-02	6.56e-02
Toll Like Receptor TLR1:TLR2 Cascade	109	9.08e-02	1.91e-01	0.14900	0.109000	-1.02e-01	4.94e-02	6.56e-02
Loss of Nlp from mitotic centrosomes	69	9.11e-02	1.91e-01	0.14900	0.034400	-1.45e-01	6.21e-01	3.73e-02
Loss of proteins required for interphase microtubule organization from the centrosome	69	9.11e-02	1.91e-01	0.14900	0.034400	-1.45e-01	6.21e-01	3.73e-02
CaMK IV-mediated phosphorylation of CREB	8	6.11e-01	7.04e-01	0.14900	-0.138000	-5.66e-02	5.00e-01	7.82e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	5.53e-01	6.55e-01	0.14900	0.128000	-7.60e-02	2.79e-01	5.19e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	50	3.15e-01	4.50e-01	0.14800	0.121000	-8.54e-02	1.38e-01	2.96e-01
Assembly of collagen fibrils and other multimeric structures	41	1.45e-01	2.66e-01	0.14800	0.148000	7.61e-03	1.01e-01	9.33e-01
TRAF6 mediated IRF7 activation	15	7.01e-01	7.77e-01	0.14800	0.079300	-1.24e-01	5.95e-01	4.04e-01
Cellular Senescence	142	4.63e-02	1.17e-01	0.14700	0.095400	-1.12e-01	4.96e-02	2.10e-02
Signaling by Activin	13	4.27e-01	5.48e-01	0.14700	-0.082900	-1.22e-01	6.05e-01	4.47e-01
Assembly Of The HIV Virion	15	3.92e-01	5.17e-01	0.14700	-0.066500	-1.31e-01	6.56e-01	3.79e-01
Neuronal System	262	5.20e-05	4.43e-04	0.14700	0.146000	-1.97e-02	4.88e-05	5.83e-01
Neddylation	215	1.06e-06	1.43e-05	0.14700	-0.078600	-1.24e-01	4.70e-02	1.69e-03
MITF-M-regulated melanocyte development	110	9.61e-02	1.97e-01	0.14600	0.110000	-9.67e-02	4.64e-02	7.98e-02
Acyl chain remodelling of PS	14	5.63e-01	6.63e-01	0.14600	0.146000	-8.82e-03	3.44e-01	9.54e-01
Notch-HLH transcription pathway	28	1.71e-01	2.95e-01	0.14600	0.074400	1.26e-01	4.95e-01	2.49e-01
Chaperone Mediated Autophagy	20	6.53e-01	7.35e-01	0.14500	0.092100	-1.12e-01	4.76e-01	3.84e-01
FGFR2b ligand binding and activation	6	7.21e-01	7.93e-01	0.14500	-0.140000	-3.94e-02	5.53e-01	8.67e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	38	3.24e-01	4.57e-01	0.14500	0.138000	-4.60e-02	1.42e-01	6.24e-01
Post-translational modification: synthesis of GPI-anchored proteins	57	2.66e-01	3.94e-01	0.14500	-0.124000	7.51e-02	1.06e-01	3.27e-01
Glycosaminoglycan metabolism	95	3.03e-02	8.63e-02	0.14500	0.143000	-1.89e-02	1.58e-02	7.50e-01
Defective Intrinsic Pathway for Apoptosis	24	3.71e-01	5.02e-01	0.14400	-0.003890	1.44e-01	9.74e-01	2.21e-01
Intraflagellar transport	47	4.90e-02	1.21e-01	0.14400	-0.108000	-9.62e-02	2.01e-01	2.54e-01
RNA Polymerase II Pre-transcription Events	77	1.12e-02	4.09e-02	0.14400	-0.058000	-1.32e-01	3.79e-01	4.50e-02
Transmission across Chemical Synapses	179	1.03e-02	3.82e-02	0.14400	0.131000	-6.05e-02	2.52e-03	1.63e-01
TRAIL signaling	8	6.04e-01	6.98e-01	0.14400	-0.088200	-1.13e-01	6.66e-01	5.79e-01
Collagen formation	63	1.34e-01	2.52e-01	0.14300	0.139000	-3.35e-02	5.59e-02	6.45e-01
Insulin receptor signalling cascade	40	2.82e-01	4.13e-01	0.14300	0.139000	-3.46e-02	1.29e-01	7.05e-01
Late Phase of HIV Life Cycle	131	9.71e-04	5.54e-03	0.14200	-0.135000	-4.34e-02	7.68e-03	3.91e-01
Diseases associated with O-glycosylation of proteins	46	7.03e-02	1.58e-01	0.14100	0.126000	6.42e-02	1.39e-01	4.51e-01
Intracellular signaling by second messengers	264	4.06e-03	1.83e-02	0.14100	0.116000	-8.03e-02	1.15e-03	2.48e-02
IRAK2 mediated activation of TAK1 complex	10	5.47e-01	6.51e-01	0.14100	-0.081000	-1.16e-01	6.57e-01	5.27e-01
PIP3 activates AKT signaling	232	9.23e-03	3.52e-02	0.14100	0.112000	-8.55e-02	3.28e-03	2.48e-02
Diseases of mitotic cell cycle	38	1.77e-01	3.02e-01	0.14000	-0.018200	-1.39e-01	8.46e-01	1.37e-01
Synthesis of GDP-mannose	6	8.47e-01	8.92e-01	0.14000	-0.044400	1.33e-01	8.51e-01	5.73e-01
RNA Polymerase I Promoter Clearance	64	1.26e-01	2.41e-01	0.14000	-0.137000	2.61e-02	5.72e-02	7.18e-01
RNA Polymerase I Transcription	64	1.26e-01	2.41e-01	0.14000	-0.137000	2.61e-02	5.72e-02	7.18e-01
XBP1(S) activates chaperone genes	44	2.49e-01	3.77e-01	0.14000	0.137000	-2.88e-02	1.16e-01	7.41e-01
Viral Infection Pathways	770	1.49e-19	7.72e-18	0.14000	-0.073800	-1.19e-01	4.94e-04	2.10e-08
Synthesis of bile acids and bile salts	25	4.47e-01	5.64e-01	0.13900	0.025900	-1.37e-01	8.23e-01	2.35e-01
Cleavage of the damaged purine	21	3.72e-01	5.02e-01	0.13900	-0.026200	-1.37e-01	8.35e-01	2.78e-01
Depurination	21	3.72e-01	5.02e-01	0.13900	-0.026200	-1.37e-01	8.35e-01	2.78e-01
Recognition and association of DNA glycosylase with site containing an affected purine	21	3.72e-01	5.02e-01	0.13900	-0.026200	-1.37e-01	8.35e-01	2.78e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	1.26e-01	2.41e-01	0.13900	0.103000	-9.38e-02	6.49e-02	9.22e-02
Toll Like Receptor TLR6:TLR2 Cascade	108	1.26e-01	2.41e-01	0.13900	0.103000	-9.38e-02	6.49e-02	9.22e-02
SUMOylation of DNA replication proteins	46	3.24e-01	4.57e-01	0.13900	-0.127000	5.58e-02	1.35e-01	5.12e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	5.83e-01	6.79e-01	0.13900	-0.138000	1.97e-02	3.40e-01	8.92e-01
Eicosanoid ligand-binding receptors	13	6.43e-01	7.30e-01	0.13900	0.018900	-1.38e-01	9.06e-01	3.90e-01
Mitochondrial RNA degradation	25	6.21e-01	7.12e-01	0.13900	-0.101000	9.48e-02	3.81e-01	4.12e-01
Cytosolic tRNA aminoacylation	24	2.45e-01	3.72e-01	0.13800	-0.109000	-8.57e-02	3.57e-01	4.67e-01
Selective autophagy	77	1.37e-02	4.75e-02	0.13800	-0.067700	-1.20e-01	3.05e-01	6.84e-02
DAG and IP3 signaling	33	4.39e-01	5.56e-01	0.13700	0.128000	-5.02e-02	2.04e-01	6.18e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	6.48e-01	7.34e-01	0.13700	0.040400	-1.31e-01	7.79e-01	3.65e-01
Formation of WDR5-containing histone-modifying complexes	42	3.31e-01	4.64e-01	0.13700	-0.130000	4.35e-02	1.46e-01	6.26e-01
TP53 Regulates Metabolic Genes	77	9.38e-02	1.95e-01	0.13700	0.025900	-1.34e-01	6.94e-01	4.16e-02
Cell junction organization	77	1.96e-01	3.23e-01	0.13700	0.119000	-6.77e-02	7.16e-02	3.04e-01
Cilium Assembly	187	3.46e-05	3.18e-04	0.13600	-0.072200	-1.16e-01	8.89e-02	6.42e-03
Heme biosynthesis	13	6.30e-01	7.20e-01	0.13600	-0.136000	8.23e-03	3.96e-01	9.59e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	5.81e-02	1.37e-01	0.13600	0.127000	4.96e-02	1.01e-01	5.21e-01
RAF-independent MAPK1/3 activation	21	3.03e-01	4.38e-01	0.13600	0.102000	8.95e-02	4.17e-01	4.78e-01
Antigen processing: Ubiquitination & Proteasome degradation	275	3.59e-06	4.32e-05	0.13600	-0.031100	-1.32e-01	3.74e-01	1.65e-04
Zinc transporters	12	8.02e-01	8.61e-01	0.13500	0.086600	-1.04e-01	6.03e-01	5.33e-01
Regulation of FOXO transcriptional activity by acetylation	10	6.08e-01	7.02e-01	0.13500	0.127000	4.71e-02	4.88e-01	7.97e-01
TP53 Regulates Transcription of Cell Death Genes	42	2.09e-01	3.35e-01	0.13500	0.001090	1.35e-01	9.90e-01	1.31e-01
Base-Excision Repair, AP Site Formation	28	2.32e-01	3.62e-01	0.13500	-0.060400	-1.20e-01	5.80e-01	2.71e-01
Synthesis of PG	8	8.67e-01	9.07e-01	0.13300	-0.101000	8.71e-02	6.21e-01	6.70e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	34	1.88e-01	3.14e-01	0.13300	-0.050200	-1.23e-01	6.12e-01	2.13e-01
Miscellaneous transport and binding events	20	6.96e-01	7.74e-01	0.13300	0.105000	-8.15e-02	4.15e-01	5.28e-01
SUMOylation of intracellular receptors	26	2.53e-01	3.82e-01	0.13300	0.113000	7.08e-02	3.20e-01	5.32e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	7	7.07e-01	7.81e-01	0.13300	0.122000	5.31e-02	5.78e-01	8.08e-01
Infectious disease	951	1.25e-16	5.45e-15	0.13200	-0.016100	-1.31e-01	4.02e-01	6.51e-12
Pregnenolone biosynthesis	10	8.35e-01	8.83e-01	0.13200	-0.080700	1.05e-01	6.59e-01	5.65e-01
Nucleotide salvage	21	6.35e-01	7.25e-01	0.13200	0.055500	-1.20e-01	6.60e-01	3.41e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	7	7.92e-01	8.54e-01	0.13200	0.008540	-1.32e-01	9.69e-01	5.46e-01
Heparan sulfate/heparin (HS-GAG) metabolism	39	4.33e-01	5.52e-01	0.13200	-0.055800	1.20e-01	5.46e-01	1.97e-01
Synthesis of IP3 and IP4 in the cytosol	22	3.10e-01	4.45e-01	0.13200	0.098800	8.69e-02	4.23e-01	4.81e-01
Reproduction	84	1.03e-01	2.08e-01	0.13100	0.029100	-1.28e-01	6.45e-01	4.30e-02
Mitotic Prophase	96	5.52e-02	1.33e-01	0.13100	0.016700	-1.30e-01	7.77e-01	2.81e-02
Macroautophagy	128	1.26e-03	6.90e-03	0.13000	-0.094200	-9.01e-02	6.58e-02	7.85e-02
CTLA4 inhibitory signaling	21	3.94e-01	5.19e-01	0.13000	-0.037200	-1.25e-01	7.68e-01	3.22e-01
Activation of PUMA and translocation to mitochondria	8	7.94e-01	8.55e-01	0.13000	-0.021000	1.28e-01	9.18e-01	5.29e-01
STING mediated induction of host immune responses	15	7.40e-01	8.09e-01	0.13000	-0.116000	5.94e-02	4.38e-01	6.91e-01
Diseases associated with the TLR signaling cascade	29	5.93e-01	6.88e-01	0.13000	0.108000	-7.15e-02	3.13e-01	5.05e-01
Diseases of Immune System	29	5.93e-01	6.88e-01	0.13000	0.108000	-7.15e-02	3.13e-01	5.05e-01
Activation of the phototransduction cascade	8	8.72e-01	9.10e-01	0.12900	0.102000	-7.91e-02	6.16e-01	6.98e-01
PTEN Regulation	126	5.33e-02	1.29e-01	0.12900	0.041500	-1.22e-01	4.21e-01	1.77e-02
Toll Like Receptor 3 (TLR3) Cascade	104	1.81e-01	3.06e-01	0.12900	0.091500	-9.11e-02	1.07e-01	1.09e-01
Assembly and cell surface presentation of NMDA receptors	30	2.30e-01	3.60e-01	0.12900	0.110000	6.62e-02	2.96e-01	5.31e-01
Signaling by TGFBR3	39	5.00e-01	6.11e-01	0.12900	0.070600	-1.07e-01	4.46e-01	2.46e-01
IRS-related events triggered by IGF1R	36	3.73e-01	5.03e-01	0.12800	0.126000	-2.34e-02	1.90e-01	8.08e-01
Dopamine Neurotransmitter Release Cycle	20	3.63e-01	4.95e-01	0.12800	0.096500	8.44e-02	4.55e-01	5.13e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	4.34e-01	5.53e-01	0.12800	0.125000	-2.83e-02	2.21e-01	7.82e-01
Ovarian tumor domain proteases	37	5.11e-01	6.22e-01	0.12800	0.109000	-6.61e-02	2.49e-01	4.87e-01
Transcriptional regulation by RUNX3	80	2.79e-01	4.09e-01	0.12700	0.093300	-8.61e-02	1.49e-01	1.83e-01
Neurexins and neuroligins	35	3.57e-01	4.90e-01	0.12700	-0.012500	1.26e-01	8.98e-01	1.97e-01
SARS-CoV Infections	428	1.10e-07	1.78e-06	0.12600	-0.022000	-1.24e-01	4.35e-01	1.06e-05
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	5.36e-01	6.42e-01	0.12600	0.046700	-1.17e-01	6.58e-01	2.69e-01
RND2 GTPase cycle	36	5.14e-01	6.25e-01	0.12600	0.111000	-5.88e-02	2.49e-01	5.42e-01
Glutathione conjugation	26	5.61e-01	6.62e-01	0.12500	0.039100	-1.19e-01	7.30e-01	2.93e-01
RND1 GTPase cycle	36	4.99e-01	6.10e-01	0.12500	0.053200	-1.13e-01	5.80e-01	2.39e-01
Purine catabolism	16	6.81e-01	7.61e-01	0.12500	-0.121000	3.08e-02	4.02e-01	8.31e-01
Regulation of TP53 Activity through Phosphorylation	88	2.05e-02	6.35e-02	0.12500	-0.052600	-1.13e-01	3.94e-01	6.63e-02
Synaptic adhesion-like molecules	14	5.89e-01	6.85e-01	0.12500	0.023500	1.23e-01	8.79e-01	4.27e-01
Metabolism of nucleotides	86	2.12e-02	6.53e-02	0.12400	-0.110000	-5.83e-02	7.84e-02	3.50e-01
Role of second messengers in netrin-1 signaling	6	9.09e-01	9.35e-01	0.12400	0.100000	-7.34e-02	6.72e-01	7.55e-01
Collagen biosynthesis and modifying enzymes	45	4.04e-01	5.27e-01	0.12400	0.115000	-4.61e-02	1.82e-01	5.93e-01
Cardiogenesis	13	8.19e-01	8.71e-01	0.12400	-0.080200	9.44e-02	6.17e-01	5.56e-01
PTK6 Regulates Cell Cycle	6	8.97e-01	9.27e-01	0.12400	0.110000	-5.65e-02	6.41e-01	8.10e-01
Gene Silencing by RNA	87	2.42e-02	7.16e-02	0.12400	-0.113000	-4.97e-02	6.83e-02	4.23e-01
Transcriptional regulation by small RNAs	61	1.91e-01	3.18e-01	0.12200	-0.122000	1.31e-02	1.00e-01	8.60e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	3.39e-01	4.72e-01	0.12200	0.115000	3.99e-02	2.99e-01	7.20e-01
The phototransduction cascade	26	3.54e-01	4.88e-01	0.12200	-0.116000	-3.94e-02	3.08e-01	7.28e-01
MyD88-independent TLR4 cascade	108	2.05e-01	3.31e-01	0.12200	0.087500	-8.51e-02	1.16e-01	1.26e-01
TRIF (TICAM1)-mediated TLR4 signaling	108	2.05e-01	3.31e-01	0.12200	0.087500	-8.51e-02	1.16e-01	1.26e-01
Autophagy	142	1.79e-03	9.41e-03	0.12200	-0.068300	-1.01e-01	1.60e-01	3.78e-02
ECM proteoglycans	45	2.00e-01	3.28e-01	0.12200	0.120000	2.25e-02	1.65e-01	7.94e-01
IGF1R signaling cascade	37	4.13e-01	5.36e-01	0.12200	0.119000	-2.48e-02	2.10e-01	7.94e-01
Arachidonate metabolism	42	3.16e-01	4.50e-01	0.12100	0.121000	-9.70e-03	1.76e-01	9.13e-01
WNT5A-dependent internalization of FZD4	13	7.06e-01	7.80e-01	0.12100	0.120000	-1.21e-02	4.52e-01	9.40e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9	6.97e-01	7.74e-01	0.12100	-0.113000	-4.38e-02	5.59e-01	8.20e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	3.60e-01	4.92e-01	0.12100	0.030600	-1.17e-01	7.19e-01	1.70e-01
Signaling by Non-Receptor Tyrosine Kinases	47	4.29e-01	5.48e-01	0.12100	0.110000	-5.06e-02	1.94e-01	5.48e-01
Signaling by PTK6	47	4.29e-01	5.48e-01	0.12100	0.110000	-5.06e-02	1.94e-01	5.48e-01
Signaling by FGFR in disease	52	2.65e-01	3.94e-01	0.12000	0.015500	-1.19e-01	8.47e-01	1.37e-01
MAP kinase activation	63	4.01e-01	5.25e-01	0.12000	0.093300	-7.50e-02	2.00e-01	3.03e-01
Glutamate Neurotransmitter Release Cycle	20	7.04e-01	7.79e-01	0.12000	0.108000	-5.10e-02	4.03e-01	6.93e-01
Interleukin-17 signaling	68	3.55e-01	4.88e-01	0.11900	0.099400	-6.62e-02	1.56e-01	3.45e-01
Transport and synthesis of PAPS	6	8.29e-01	8.79e-01	0.11900	-0.009510	-1.19e-01	9.68e-01	6.14e-01
Adipogenesis	95	2.36e-01	3.66e-01	0.11900	0.099600	-6.53e-02	9.35e-02	2.71e-01
PI-3K cascade:FGFR1	13	7.84e-01	8.47e-01	0.11900	0.111000	-4.35e-02	4.90e-01	7.86e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	4.83e-01	5.95e-01	0.11900	0.067600	-9.75e-02	4.13e-01	2.38e-01
Organelle biogenesis and maintenance	278	7.97e-06	8.90e-05	0.11900	-0.069100	-9.65e-02	4.73e-02	5.64e-03
Transport of small molecules	548	4.03e-04	2.58e-03	0.11800	0.096400	-6.82e-02	1.15e-04	6.34e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	7.75e-01	8.38e-01	0.11800	0.011400	-1.17e-01	9.50e-01	5.20e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	6.91e-01	7.70e-01	0.11800	-0.037000	-1.12e-01	8.39e-01	5.41e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	5.77e-01	6.75e-01	0.11800	0.092800	7.23e-02	5.62e-01	6.52e-01
Neurotransmitter release cycle	38	4.33e-01	5.52e-01	0.11700	0.115000	-2.52e-02	2.21e-01	7.88e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.13e-01	4.48e-01	0.11700	-0.017200	-1.16e-01	8.58e-01	2.28e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	6.35e-01	7.25e-01	0.11700	-0.117000	-1.71e-03	4.17e-01	9.91e-01
mTORC1-mediated signalling	24	4.30e-01	5.50e-01	0.11700	-0.030100	-1.13e-01	7.99e-01	3.37e-01
Biosynthesis of DHA-derived SPMs	13	5.92e-01	6.88e-01	0.11700	0.102000	5.79e-02	5.25e-01	7.18e-01
RNA Polymerase I Promoter Escape	45	2.42e-01	3.70e-01	0.11700	-0.116000	-1.58e-02	1.80e-01	8.55e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	4.28e-01	5.48e-01	0.11600	0.098700	6.17e-02	4.34e-01	6.24e-01
Neurodegenerative Diseases	21	4.28e-01	5.48e-01	0.11600	0.098700	6.17e-02	4.34e-01	6.24e-01
Reversal of alkylation damage by DNA dioxygenases	7	9.10e-01	9.35e-01	0.11600	-0.085800	7.85e-02	6.94e-01	7.19e-01
Phospholipase C-mediated cascade; FGFR3	5	8.44e-01	8.90e-01	0.11600	0.027100	1.13e-01	9.17e-01	6.62e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	7.93e-01	8.54e-01	0.11600	-0.097000	6.38e-02	5.02e-01	6.58e-01
Anchoring of the basal body to the plasma membrane	97	4.03e-02	1.06e-01	0.11600	-0.024700	-1.13e-01	6.75e-01	5.41e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	8	7.28e-01	7.99e-01	0.11600	-0.099000	-5.99e-02	6.28e-01	7.69e-01
FOXO-mediated transcription	57	2.43e-01	3.71e-01	0.11600	0.115000	-1.01e-02	1.32e-01	8.95e-01
Triglyceride biosynthesis	9	7.03e-01	7.78e-01	0.11500	0.059800	9.80e-02	7.56e-01	6.11e-01
Protein-protein interactions at synapses	54	1.72e-01	2.97e-01	0.11500	0.025000	1.12e-01	7.51e-01	1.55e-01
Nuclear signaling by ERBB4	24	4.13e-01	5.36e-01	0.11400	0.104000	4.68e-02	3.77e-01	6.91e-01
HSF1 activation	25	7.10e-01	7.83e-01	0.11400	0.065900	-9.33e-02	5.68e-01	4.19e-01
FRS-mediated FGFR1 signaling	15	8.11e-01	8.66e-01	0.11400	0.095200	-6.28e-02	5.23e-01	6.74e-01
HDACs deacetylate histones	45	5.46e-01	6.51e-01	0.11400	0.092000	-6.69e-02	2.86e-01	4.38e-01
DNA Double-Strand Break Repair	137	4.83e-03	2.07e-02	0.11400	-0.066200	-9.23e-02	1.81e-01	6.21e-02
IRS-mediated signalling	35	4.88e-01	6.00e-01	0.11400	0.111000	-2.48e-02	2.57e-01	7.99e-01
VLDLR internalisation and degradation	16	6.99e-01	7.75e-01	0.11300	-0.016000	1.12e-01	9.12e-01	4.38e-01
Resolution of D-Loop Structures	35	3.27e-01	4.60e-01	0.11300	-0.025400	-1.10e-01	7.95e-01	2.59e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	7.37e-01	8.07e-01	0.11300	0.066800	-9.12e-02	5.79e-01	4.49e-01
Metabolism of proteins	1761	2.15e-28	3.17e-26	0.11300	-0.079800	-7.98e-02	2.80e-08	2.79e-08
Inactivation, recovery and regulation of the phototransduction cascade	25	3.79e-01	5.06e-01	0.11200	-0.081200	-7.73e-02	4.82e-01	5.04e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	14	8.11e-01	8.66e-01	0.11200	-0.099800	5.08e-02	5.18e-01	7.42e-01
Cellular hexose transport	14	6.12e-01	7.04e-01	0.11200	0.044400	1.03e-01	7.74e-01	5.06e-01
Metabolism of lipids	632	2.26e-04	1.59e-03	0.11200	0.059600	-9.47e-02	1.06e-02	4.88e-05
Post-translational protein modification	1232	2.18e-11	5.50e-10	0.11200	0.018700	-1.10e-01	2.70e-01	8.00e-11
Intrinsic Pathway for Apoptosis	53	1.50e-01	2.72e-01	0.11100	-0.099100	-5.09e-02	2.12e-01	5.21e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	8.15e-01	8.68e-01	0.11100	0.057900	-9.49e-02	6.98e-01	5.25e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	6.71e-01	7.52e-01	0.11100	-0.054000	-9.71e-02	7.56e-01	5.77e-01
Drug ADME	55	5.07e-01	6.18e-01	0.11100	0.085000	-7.12e-02	2.76e-01	3.61e-01
SLC transporter disorders	75	3.99e-01	5.23e-01	0.11100	-0.071500	8.43e-02	2.84e-01	2.07e-01
Post NMDA receptor activation events	60	4.73e-01	5.89e-01	0.11000	0.066900	-8.77e-02	3.70e-01	2.40e-01
Passive transport by Aquaporins	6	8.91e-01	9.25e-01	0.11000	-0.023500	1.07e-01	9.21e-01	6.49e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	8.71e-02	1.85e-01	0.11000	-0.079400	-7.55e-02	2.65e-01	2.89e-01
Nuclear Envelope (NE) Reassembly	68	3.18e-01	4.50e-01	0.10900	0.033800	-1.04e-01	6.30e-01	1.39e-01
Lewis blood group biosynthesis	13	8.49e-01	8.93e-01	0.10900	-0.090000	6.07e-02	5.74e-01	7.05e-01
Inflammasomes	21	4.91e-01	6.03e-01	0.10800	0.096900	4.87e-02	4.42e-01	6.99e-01
Signaling by NOTCH1	66	2.09e-01	3.35e-01	0.10800	0.108000	-5.13e-04	1.28e-01	9.94e-01
Interferon gamma signaling	87	4.38e-02	1.13e-01	0.10800	-0.072100	-8.07e-02	2.45e-01	1.93e-01
Formation of RNA Pol II elongation complex	56	1.38e-01	2.57e-01	0.10800	-0.061800	-8.88e-02	4.24e-01	2.50e-01
RNA Polymerase II Transcription Elongation	56	1.38e-01	2.57e-01	0.10800	-0.061800	-8.88e-02	4.24e-01	2.50e-01
Recruitment of NuMA to mitotic centrosomes	88	1.93e-01	3.20e-01	0.10800	0.022900	-1.06e-01	7.10e-01	8.67e-02
Inositol phosphate metabolism	42	6.16e-01	7.08e-01	0.10800	0.077200	-7.55e-02	3.87e-01	3.97e-01
TRP channels	21	6.41e-01	7.30e-01	0.10800	0.107000	-1.09e-02	3.96e-01	9.31e-01
FasL/ CD95L signaling	5	8.47e-01	8.92e-01	0.10700	-0.096100	-4.80e-02	7.10e-01	8.53e-01
Disease	1606	1.23e-14	4.36e-13	0.10700	0.008750	-1.07e-01	5.59e-01	9.09e-13
Sphingolipid metabolism	92	3.51e-01	4.86e-01	0.10700	0.072100	-7.93e-02	2.32e-01	1.89e-01
LDL clearance	18	5.31e-01	6.37e-01	0.10700	0.081900	6.89e-02	5.47e-01	6.13e-01
MyD88 cascade initiated on plasma membrane	95	3.18e-01	4.50e-01	0.10600	0.088400	-5.93e-02	1.36e-01	3.18e-01
Toll Like Receptor 10 (TLR10) Cascade	95	3.18e-01	4.50e-01	0.10600	0.088400	-5.93e-02	1.36e-01	3.18e-01
Toll Like Receptor 5 (TLR5) Cascade	95	3.18e-01	4.50e-01	0.10600	0.088400	-5.93e-02	1.36e-01	3.18e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	7.46e-01	8.14e-01	0.10600	0.089100	-5.80e-02	4.50e-01	6.23e-01
ERKs are inactivated	13	7.49e-01	8.16e-01	0.10600	-0.003460	1.06e-01	9.83e-01	5.07e-01
Death Receptor Signaling	145	1.84e-01	3.10e-01	0.10600	0.086200	-6.17e-02	7.33e-02	2.00e-01
Signaling by Retinoic Acid	29	4.98e-01	6.10e-01	0.10600	-0.106000	-5.35e-03	3.25e-01	9.60e-01
Senescence-Associated Secretory Phenotype (SASP)	64	4.83e-01	5.95e-01	0.10600	0.083300	-6.52e-02	2.49e-01	3.67e-01
SLC15A4:TASL-dependent IRF5 activation	6	8.73e-01	9.10e-01	0.10500	-0.105000	-4.24e-04	6.56e-01	9.99e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	78	4.27e-01	5.48e-01	0.10500	0.070200	-7.78e-02	2.84e-01	2.35e-01
CASP8 activity is inhibited	11	6.90e-01	7.68e-01	0.10500	-0.079400	-6.83e-02	6.49e-01	6.95e-01
Dimerization of procaspase-8	11	6.90e-01	7.68e-01	0.10500	-0.079400	-6.83e-02	6.49e-01	6.95e-01
Regulation by c-FLIP	11	6.90e-01	7.68e-01	0.10500	-0.079400	-6.83e-02	6.49e-01	6.95e-01
Negative feedback regulation of MAPK pathway	6	8.34e-01	8.83e-01	0.10400	0.096800	3.92e-02	6.81e-01	8.68e-01
Signaling by BRAF and RAF1 fusions	59	4.92e-01	6.04e-01	0.10400	0.053800	-8.92e-02	4.75e-01	2.36e-01
Regulation of endogenous retroelements by KRAB-ZFP proteins	61	2.56e-01	3.84e-01	0.10400	-0.001880	-1.04e-01	9.80e-01	1.61e-01
Regulation of FZD by ubiquitination	15	8.52e-01	8.95e-01	0.10400	0.074000	-7.28e-02	6.20e-01	6.25e-01
SIRT1 negatively regulates rRNA expression	22	5.91e-01	6.87e-01	0.10400	-0.009250	-1.03e-01	9.40e-01	4.02e-01
Sensory processing of sound	57	3.91e-01	5.17e-01	0.10300	0.099800	-2.37e-02	1.92e-01	7.57e-01
Intra-Golgi traffic	43	5.69e-01	6.67e-01	0.10200	0.041900	-9.34e-02	6.34e-01	2.89e-01
Signaling by FGFR1	42	6.45e-01	7.33e-01	0.10200	0.065400	-7.81e-02	4.63e-01	3.81e-01
DNA Double Strand Break Response	47	4.74e-01	5.89e-01	0.10200	0.025300	-9.87e-02	7.64e-01	2.42e-01
Regulation of TP53 Degradation	35	3.26e-01	4.58e-01	0.10200	-0.072400	-7.17e-02	4.58e-01	4.63e-01
Regulation of MITF-M-dependent genes involved in pigmentation	35	3.89e-01	5.15e-01	0.10200	0.097800	2.85e-02	3.17e-01	7.70e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	30	5.34e-01	6.42e-01	0.10100	0.000341	-1.01e-01	9.97e-01	3.36e-01
Disorders of transmembrane transporters	134	9.83e-02	2.01e-01	0.10100	0.016200	-9.97e-02	7.46e-01	4.63e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	6.68e-02	1.53e-01	0.10100	-0.026700	-9.71e-02	6.39e-01	8.70e-02
p75 NTR receptor-mediated signalling	89	3.11e-01	4.46e-01	0.10000	0.093000	-3.75e-02	1.29e-01	5.41e-01
G-protein beta:gamma signalling	29	6.75e-01	7.55e-01	0.10000	0.034800	-9.38e-02	7.46e-01	3.82e-01
Carboxyterminal post-translational modifications of tubulin	33	4.11e-01	5.35e-01	0.09940	0.093100	3.48e-02	3.55e-01	7.29e-01
SARS-CoV-2 Infection	263	5.61e-04	3.38e-03	0.09940	-0.087500	-4.71e-02	1.46e-02	1.89e-01
Amyloid fiber formation	51	3.72e-01	5.02e-01	0.09900	0.002630	-9.89e-02	9.74e-01	2.22e-01
Metal ion SLC transporters	19	7.83e-01	8.46e-01	0.09900	0.091800	-3.70e-02	4.88e-01	7.80e-01
Amine ligand-binding receptors	10	8.19e-01	8.71e-01	0.09850	0.098500	6.87e-04	5.90e-01	9.97e-01
Oncogenic MAPK signaling	75	4.70e-01	5.85e-01	0.09820	0.057000	-8.00e-02	3.94e-01	2.31e-01
Negative epigenetic regulation of rRNA expression	63	1.91e-01	3.19e-01	0.09740	-0.090300	-3.66e-02	2.15e-01	6.16e-01
TGFBR3 PTM regulation	10	8.90e-01	9.25e-01	0.09680	0.040700	-8.79e-02	8.24e-01	6.30e-01
Fertilization	12	7.12e-01	7.85e-01	0.09650	0.077600	5.73e-02	6.42e-01	7.31e-01
Phospholipase C-mediated cascade; FGFR4	6	8.62e-01	9.03e-01	0.09640	0.029700	9.17e-02	9.00e-01	6.97e-01
Regulation of endogenous retroelements	92	2.86e-01	4.16e-01	0.09610	0.026600	-9.23e-02	6.59e-01	1.26e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	4.10e-01	5.33e-01	0.09590	0.095600	7.78e-03	2.73e-01	9.29e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	6.96e-01	7.74e-01	0.09570	-0.077300	-5.65e-02	6.30e-01	7.24e-01
Sensory processing of sound by inner hair cells of the cochlea	54	3.94e-01	5.19e-01	0.09570	0.095400	-7.04e-03	2.25e-01	9.29e-01
Carnitine shuttle	12	8.94e-01	9.26e-01	0.09570	-0.074900	5.95e-02	6.53e-01	7.21e-01
TNFR1-induced proapoptotic signaling	24	6.96e-01	7.74e-01	0.09570	0.094000	-1.79e-02	4.26e-01	8.80e-01
Josephin domain DUBs	10	8.36e-01	8.83e-01	0.09550	0.003130	-9.54e-02	9.86e-01	6.01e-01
Centrosome maturation	81	1.76e-01	3.02e-01	0.09510	-0.015700	-9.38e-02	8.07e-01	1.45e-01
Recruitment of mitotic centrosome proteins and complexes	81	1.76e-01	3.02e-01	0.09510	-0.015700	-9.38e-02	8.07e-01	1.45e-01
Plasma lipoprotein clearance	33	4.38e-01	5.56e-01	0.09450	0.037500	8.67e-02	7.10e-01	3.89e-01
Homology Directed Repair	110	5.78e-02	1.37e-01	0.09390	-0.047400	-8.10e-02	3.90e-01	1.42e-01
Developmental Biology	906	4.63e-04	2.90e-03	0.09360	0.059600	-7.22e-02	2.36e-03	2.30e-04
PI3K Cascade	31	5.20e-01	6.29e-01	0.09330	0.091700	1.73e-02	3.77e-01	8.68e-01
Vitamin B2 (riboflavin) metabolism	6	9.48e-01	9.62e-01	0.09290	-0.056600	7.37e-02	8.10e-01	7.55e-01
TRAF6 mediated NF-kB activation	23	7.67e-01	8.32e-01	0.09290	-0.033100	8.68e-02	7.83e-01	4.71e-01
Retrograde neurotrophin signalling	12	8.56e-01	8.97e-01	0.09290	0.089600	-2.45e-02	5.91e-01	8.83e-01
EPH-ephrin mediated repulsion of cells	42	5.82e-01	6.79e-01	0.09200	0.023400	-8.90e-02	7.93e-01	3.19e-01
Cytosolic sensors of pathogen-associated DNA	63	4.45e-01	5.63e-01	0.09170	-0.088800	2.30e-02	2.23e-01	7.53e-01
RHOBTB3 ATPase cycle	10	8.14e-01	8.68e-01	0.09150	0.089600	1.88e-02	6.24e-01	9.18e-01
Nucleotide catabolism	29	5.30e-01	6.37e-01	0.09060	-0.028800	-8.59e-02	7.89e-01	4.23e-01
TRAF3-dependent IRF activation pathway	13	8.71e-01	9.09e-01	0.08990	0.033300	-8.35e-02	8.36e-01	6.02e-01
Pyrimidine salvage	10	9.15e-01	9.37e-01	0.08940	0.076900	-4.57e-02	6.74e-01	8.02e-01
SARS-CoV-1 activates/modulates innate immune responses	40	3.81e-01	5.07e-01	0.08890	-0.054500	-7.03e-02	5.51e-01	4.42e-01
Cytosolic sulfonation of small molecules	18	7.39e-01	8.08e-01	0.08860	0.004430	8.85e-02	9.74e-01	5.16e-01
RNA Polymerase II Transcription	1185	1.87e-09	3.78e-08	0.08830	-0.011100	-8.76e-02	5.22e-01	3.84e-07
Regulation of signaling by NODAL	6	9.12e-01	9.36e-01	0.08820	-0.088100	2.48e-03	7.09e-01	9.92e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	4.25e-01	5.47e-01	0.08810	-0.085100	2.28e-02	2.09e-01	7.36e-01
NoRC negatively regulates rRNA expression	60	2.46e-01	3.73e-01	0.08790	-0.071600	-5.10e-02	3.37e-01	4.94e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	7.54e-01	8.20e-01	0.08770	0.084000	2.53e-02	5.86e-01	8.70e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	7.54e-01	8.20e-01	0.08770	0.084000	2.53e-02	5.86e-01	8.70e-01
TNF signaling	56	6.07e-01	7.01e-01	0.08690	0.039800	-7.73e-02	6.07e-01	3.17e-01
Signaling by Hippo	18	8.48e-01	8.92e-01	0.08670	0.037400	-7.82e-02	7.84e-01	5.66e-01
VEGFR2 mediated vascular permeability	26	6.54e-01	7.36e-01	0.08620	0.085900	6.62e-03	4.48e-01	9.53e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	23	8.38e-01	8.85e-01	0.08610	-0.069200	5.12e-02	5.65e-01	6.71e-01
Negative regulation of MAPK pathway	42	7.33e-01	8.04e-01	0.08610	0.064800	-5.66e-02	4.67e-01	5.26e-01
Aspartate and asparagine metabolism	8	9.41e-01	9.58e-01	0.08590	-0.068100	5.24e-02	7.39e-01	7.97e-01
RNA polymerase II transcribes snRNA genes	71	2.03e-01	3.31e-01	0.08580	-0.067600	-5.28e-02	3.25e-01	4.42e-01
Signaling by FGFR2 in disease	33	4.75e-01	5.89e-01	0.08570	-0.064200	-5.67e-02	5.23e-01	5.73e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	107	1.61e-01	2.85e-01	0.08560	-0.084800	-1.23e-02	1.30e-01	8.26e-01
Association of TriC/CCT with target proteins during biosynthesis	35	4.80e-01	5.93e-01	0.08540	-0.038100	-7.64e-02	6.96e-01	4.34e-01
Visual phototransduction	58	3.90e-01	5.17e-01	0.08530	0.085000	7.86e-03	2.63e-01	9.18e-01
Generic Transcription Pathway	1067	1.30e-07	2.05e-06	0.08500	-0.005030	-8.48e-02	7.81e-01	2.89e-06
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	7.33e-01	8.04e-01	0.08430	-0.074200	-4.00e-02	6.19e-01	7.89e-01
Costimulation by the CD28 family	74	2.63e-01	3.91e-01	0.08400	-0.081200	-2.17e-02	2.27e-01	7.47e-01
Formation of definitive endoderm	8	9.28e-01	9.49e-01	0.08400	0.078100	-3.07e-02	7.02e-01	8.80e-01
Glycogen storage diseases	13	8.31e-01	8.81e-01	0.08400	-0.084000	7.32e-04	6.00e-01	9.96e-01
Urea cycle	6	8.98e-01	9.27e-01	0.08400	0.081200	2.14e-02	7.31e-01	9.28e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	7.47e-01	8.14e-01	0.08390	0.081300	-2.05e-02	4.65e-01	8.53e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	10	8.05e-01	8.63e-01	0.08380	0.056400	6.20e-02	7.57e-01	7.34e-01
Diseases associated with glycosylation precursor biosynthesis	15	8.71e-01	9.09e-01	0.08360	-0.077700	3.10e-02	6.03e-01	8.35e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	105	4.71e-01	5.87e-01	0.08350	0.066800	-5.00e-02	2.37e-01	3.76e-01
FGFRL1 modulation of FGFR1 signaling	7	9.51e-01	9.64e-01	0.08340	0.049300	-6.72e-02	8.21e-01	7.58e-01
SUMOylation of DNA methylation proteins	16	8.35e-01	8.83e-01	0.08340	-0.016900	8.16e-02	9.07e-01	5.72e-01
Activation of NMDA receptors and postsynaptic events	70	6.09e-01	7.03e-01	0.08320	0.066000	-5.07e-02	3.39e-01	4.64e-01
Mitochondrial biogenesis	91	1.44e-01	2.66e-01	0.08320	-0.061800	-5.57e-02	3.09e-01	3.58e-01
Phospholipid metabolism	182	2.89e-01	4.20e-01	0.08280	0.053500	-6.32e-02	2.13e-01	1.42e-01
Gene expression (Transcription)	1391	1.00e-10	2.34e-09	0.08190	-0.024400	-7.82e-02	1.27e-01	1.05e-06
Phase I - Functionalization of compounds	62	4.16e-01	5.39e-01	0.08190	0.002910	8.18e-02	9.68e-01	2.65e-01
MyD88 dependent cascade initiated on endosome	101	4.83e-01	5.95e-01	0.08100	0.069100	-4.24e-02	2.30e-01	4.62e-01
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	18	8.07e-01	8.64e-01	0.08080	-0.080400	8.36e-03	5.55e-01	9.51e-01
Beta-oxidation of very long chain fatty acids	11	9.31e-01	9.51e-01	0.08050	0.059800	-5.39e-02	7.31e-01	7.57e-01
Amino acid transport across the plasma membrane	24	6.39e-01	7.29e-01	0.08000	-0.037800	-7.05e-02	7.49e-01	5.50e-01
Transcriptional Regulation by VENTX	38	6.15e-01	7.07e-01	0.07920	-0.079200	-7.19e-05	3.98e-01	9.99e-01
Metabolism of porphyrins	22	6.63e-01	7.45e-01	0.07880	0.044100	6.52e-02	7.20e-01	5.96e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8	9.07e-01	9.35e-01	0.07790	0.001110	-7.79e-02	9.96e-01	7.03e-01
Signaling by NOTCH2	33	5.43e-01	6.48e-01	0.07790	0.047000	6.21e-02	6.40e-01	5.37e-01
Toll Like Receptor 9 (TLR9) Cascade	108	5.24e-01	6.32e-01	0.07790	0.056500	-5.36e-02	3.10e-01	3.36e-01
Nicotinamide salvaging	15	9.14e-01	9.37e-01	0.07780	0.051700	-5.81e-02	7.29e-01	6.97e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	8.34e-01	8.83e-01	0.07720	0.077200	-5.96e-04	6.05e-01	9.97e-01
Listeria monocytogenes entry into host cells	17	8.09e-01	8.65e-01	0.07600	-0.004500	-7.59e-02	9.74e-01	5.88e-01
Positive epigenetic regulation of rRNA expression	60	6.81e-01	7.61e-01	0.07520	-0.065200	3.74e-02	3.82e-01	6.16e-01
Paracetamol ADME	19	7.20e-01	7.92e-01	0.07490	0.055100	5.07e-02	6.78e-01	7.02e-01
Caspase activation via Death Receptors in the presence of ligand	16	8.10e-01	8.66e-01	0.07450	-0.073500	-1.22e-02	6.11e-01	9.33e-01
Metabolism of water-soluble vitamins and cofactors	114	1.63e-01	2.87e-01	0.07360	-0.037000	-6.37e-02	4.96e-01	2.40e-01
Nef Mediated CD4 Down-regulation	9	8.63e-01	9.04e-01	0.07320	0.044300	5.83e-02	8.18e-01	7.62e-01
Sensory processing of sound by outer hair cells of the cochlea	40	5.43e-01	6.48e-01	0.07280	0.065000	3.29e-02	4.77e-01	7.19e-01
FOXO-mediated transcription of cell cycle genes	14	8.92e-01	9.26e-01	0.07260	0.070500	-1.75e-02	6.48e-01	9.10e-01
Prevention of phagosomal-lysosomal fusion	9	8.70e-01	9.09e-01	0.07260	-0.035800	-6.31e-02	8.52e-01	7.43e-01
NGF-stimulated transcription	32	6.00e-01	6.95e-01	0.07250	0.058500	4.28e-02	5.67e-01	6.75e-01
SLC-mediated transmembrane transport	171	3.18e-01	4.50e-01	0.07230	0.066700	-2.80e-02	1.32e-01	5.28e-01
Transcriptional activation of mitochondrial biogenesis	52	7.40e-01	8.09e-01	0.07210	0.037000	-6.19e-02	6.44e-01	4.40e-01
Metabolism	1808	2.05e-11	5.25e-10	0.07190	-0.064500	-3.18e-02	5.47e-06	2.52e-02
Fatty acid metabolism	152	1.07e-01	2.14e-01	0.07160	-0.032200	-6.40e-02	4.93e-01	1.73e-01
Defensins	8	9.17e-01	9.39e-01	0.07150	0.002580	7.15e-02	9.90e-01	7.26e-01
MECP2 regulates transcription factors	5	9.42e-01	9.58e-01	0.07150	-0.010800	-7.07e-02	9.67e-01	7.84e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	8.73e-01	9.10e-01	0.07130	0.070000	1.36e-02	6.88e-01	9.38e-01
TICAM1-dependent activation of IRF3/IRF7	13	8.16e-01	8.69e-01	0.07130	-0.046900	-5.36e-02	7.70e-01	7.38e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	6.68e-01	7.49e-01	0.07110	-0.036000	-6.14e-02	7.46e-01	5.81e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	5.53e-01	6.55e-01	0.07110	0.063000	-3.30e-02	2.76e-01	5.69e-01
Cellular responses to stimuli	776	8.78e-04	5.05e-03	0.07040	0.004760	-7.02e-02	8.22e-01	8.79e-04
Regulation of HSF1-mediated heat shock response	78	3.74e-01	5.03e-01	0.06970	-0.067000	-1.93e-02	3.06e-01	7.68e-01
Regulation of PTEN gene transcription	59	6.67e-01	7.48e-01	0.06960	-0.021600	6.61e-02	7.74e-01	3.80e-01
Nuclear Envelope Breakdown	53	5.22e-01	6.30e-01	0.06940	-0.067100	-1.76e-02	3.98e-01	8.25e-01
Cell-cell junction organization	56	4.74e-01	5.89e-01	0.06860	0.062400	2.86e-02	4.19e-01	7.12e-01
Axon guidance	455	4.57e-02	1.16e-01	0.06860	0.019300	-6.58e-02	4.80e-01	1.62e-02
Regulation of TNFR1 signaling	47	8.04e-01	8.63e-01	0.06830	0.050400	-4.61e-02	5.50e-01	5.85e-01
Regulation of TP53 Expression and Degradation	36	5.96e-01	6.91e-01	0.06830	-0.045600	-5.09e-02	6.36e-01	5.97e-01
RMTs methylate histone arginines	35	8.38e-01	8.85e-01	0.06830	-0.057400	3.70e-02	5.57e-01	7.05e-01
Sensory perception of taste	23	8.09e-01	8.65e-01	0.06830	-0.002020	6.82e-02	9.87e-01	5.71e-01
Nervous system development	473	3.30e-02	9.23e-02	0.06810	0.015000	-6.64e-02	5.77e-01	1.33e-02
MTOR signalling	39	6.28e-01	7.18e-01	0.06790	-0.065400	-1.85e-02	4.80e-01	8.41e-01
Sperm Motility And Taxes	6	9.67e-01	9.74e-01	0.06770	-0.028700	6.13e-02	9.03e-01	7.95e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	8.90e-01	9.25e-01	0.06660	-0.061900	2.46e-02	6.32e-01	8.49e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	20	8.05e-01	8.63e-01	0.06530	0.016100	6.33e-02	9.01e-01	6.24e-01
Signaling by FGFR2	61	4.50e-01	5.66e-01	0.06520	-0.047800	-4.43e-02	5.19e-01	5.49e-01
Activation of HOX genes during differentiation	68	4.75e-01	5.89e-01	0.06410	-0.020400	-6.08e-02	7.71e-01	3.86e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	68	4.75e-01	5.89e-01	0.06410	-0.020400	-6.08e-02	7.71e-01	3.86e-01
Cell death signalling via NRAGE, NRIF and NADE	69	7.45e-01	8.13e-01	0.06370	0.052300	-3.64e-02	4.53e-01	6.02e-01
Transcriptional Regulation by TP53	343	2.15e-02	6.60e-02	0.06360	-0.025600	-5.82e-02	4.15e-01	6.41e-02
Xenobiotics	9	8.98e-01	9.27e-01	0.06340	0.053900	3.34e-02	7.79e-01	8.62e-01
Negative regulation of FGFR1 signaling	25	9.03e-01	9.32e-01	0.06270	0.037200	-5.04e-02	7.47e-01	6.63e-01
Regulation of TP53 Activity	151	2.07e-01	3.34e-01	0.06230	-0.058800	-2.08e-02	2.13e-01	6.60e-01
Lysosome Vesicle Biogenesis	32	7.18e-01	7.90e-01	0.06230	-0.020000	-5.90e-02	8.45e-01	5.64e-01
Vitamin D (calciferol) metabolism	10	9.63e-01	9.71e-01	0.06130	0.038400	-4.77e-02	8.33e-01	7.94e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	8.66e-01	9.06e-01	0.06120	0.011000	-6.02e-02	9.27e-01	6.17e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	6.88e-01	7.68e-01	0.06070	0.060400	-6.50e-03	4.34e-01	9.33e-01
Basigin interactions	21	9.27e-01	9.48e-01	0.06020	0.045100	-3.99e-02	7.21e-01	7.52e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	8.91e-01	9.25e-01	0.06020	0.035900	-4.82e-02	7.29e-01	6.42e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	8.80e-01	9.17e-01	0.06000	0.010200	-5.91e-02	9.36e-01	6.39e-01
Aflatoxin activation and detoxification	14	9.51e-01	9.64e-01	0.05970	0.038800	-4.54e-02	8.02e-01	7.69e-01
Cellular responses to stress	694	1.07e-03	5.96e-03	0.05960	-0.026000	-5.37e-02	2.44e-01	1.60e-02
Nuclear Events (kinase and transcription factor activation)	54	7.10e-01	7.83e-01	0.05930	0.058900	-6.46e-03	4.54e-01	9.35e-01
PKMTs methylate histone lysines	42	8.56e-01	8.97e-01	0.05830	0.049300	-3.12e-02	5.80e-01	7.27e-01
Activated point mutants of FGFR2	7	9.45e-01	9.60e-01	0.05820	-0.010300	-5.73e-02	9.62e-01	7.93e-01
IRAK1 recruits IKK complex	14	8.94e-01	9.26e-01	0.05820	-0.057500	-9.15e-03	7.10e-01	9.53e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	8.94e-01	9.26e-01	0.05820	-0.057500	-9.15e-03	7.10e-01	9.53e-01
Epigenetic regulation of gene expression	263	2.18e-01	3.45e-01	0.05810	0.008470	-5.75e-02	8.13e-01	1.09e-01
Cellular response to heat stress	92	6.74e-01	7.54e-01	0.05710	-0.053100	2.10e-02	3.79e-01	7.28e-01
TNFs bind their physiological receptors	25	9.04e-01	9.32e-01	0.05670	0.023200	-5.17e-02	8.41e-01	6.54e-01
Phase II - Conjugation of compounds	68	6.25e-01	7.15e-01	0.05670	-0.003280	-5.66e-02	9.63e-01	4.20e-01
Endogenous sterols	17	8.56e-01	8.97e-01	0.05610	0.026600	4.94e-02	8.49e-01	7.25e-01
Cargo recognition for clathrin-mediated endocytosis	88	6.11e-01	7.04e-01	0.05550	0.005790	-5.52e-02	9.25e-01	3.71e-01
Metabolism of folate and pterines	16	9.46e-01	9.61e-01	0.05530	-0.027800	4.78e-02	8.47e-01	7.41e-01
Diseases of glycosylation	104	4.21e-01	5.43e-01	0.05470	0.021300	5.04e-02	7.08e-01	3.74e-01
NCAM signaling for neurite out-growth	47	8.19e-01	8.71e-01	0.05460	0.052000	-1.69e-02	5.38e-01	8.41e-01
Metabolic disorders of biological oxidation enzymes	23	8.22e-01	8.73e-01	0.05390	0.046900	2.66e-02	6.97e-01	8.25e-01
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	11	9.09e-01	9.35e-01	0.05340	-0.043100	-3.15e-02	8.04e-01	8.56e-01
Synthesis of PA	31	8.01e-01	8.61e-01	0.05340	-0.012400	-5.19e-02	9.05e-01	6.17e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	7	9.63e-01	9.71e-01	0.05330	0.053200	-3.44e-03	8.08e-01	9.87e-01
Reactions specific to the complex N-glycan synthesis pathway	7	9.61e-01	9.70e-01	0.05270	-0.000471	-5.27e-02	9.98e-01	8.09e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	6.51e-01	7.35e-01	0.05150	0.040700	3.16e-02	6.08e-01	6.91e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	6.51e-01	7.35e-01	0.05150	0.040700	3.16e-02	6.08e-01	6.91e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	6.51e-01	7.35e-01	0.05150	0.040700	3.16e-02	6.08e-01	6.91e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	6.51e-01	7.35e-01	0.05150	0.040700	3.16e-02	6.08e-01	6.91e-01
Signaling by NOTCH1 in Cancer	53	6.51e-01	7.35e-01	0.05150	0.040700	3.16e-02	6.08e-01	6.91e-01
TRIF-mediated programmed cell death	9	9.39e-01	9.57e-01	0.05000	-0.020100	-4.58e-02	9.17e-01	8.12e-01
SUMOylation of transcription cofactors	44	8.50e-01	8.93e-01	0.04760	-0.009340	4.67e-02	9.15e-01	5.92e-01
Glucose metabolism	76	8.46e-01	8.92e-01	0.04720	0.034200	-3.26e-02	6.06e-01	6.23e-01
WNT ligand biogenesis and trafficking	20	8.96e-01	9.27e-01	0.04710	-0.010200	-4.60e-02	9.37e-01	7.22e-01
Glyoxylate metabolism and glycine degradation	13	9.16e-01	9.38e-01	0.04710	-0.037100	-2.89e-02	8.17e-01	8.57e-01
HCMV Infection	106	4.86e-01	5.98e-01	0.04710	-0.032500	-3.41e-02	5.63e-01	5.45e-01
Transport of RCbl within the body	8	9.60e-01	9.70e-01	0.04620	-0.008030	-4.55e-02	9.69e-01	8.24e-01
HCMV Early Events	84	7.67e-01	8.32e-01	0.04570	-0.044100	1.17e-02	4.84e-01	8.53e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	35	9.31e-01	9.51e-01	0.04510	-0.035000	2.85e-02	7.20e-01	7.71e-01
Glycolysis	68	8.58e-01	9.00e-01	0.04480	0.022600	-3.86e-02	7.47e-01	5.82e-01
Biological oxidations	135	7.63e-01	8.28e-01	0.04430	-0.026900	3.52e-02	5.89e-01	4.80e-01
Diseases associated with glycosaminoglycan metabolism	24	8.93e-01	9.26e-01	0.04400	0.043200	8.53e-03	7.14e-01	9.42e-01
Acyl chain remodelling of PE	19	9.64e-01	9.72e-01	0.04400	-0.029300	3.28e-02	8.25e-01	8.05e-01
FGFR4 ligand binding and activation	5	9.79e-01	9.84e-01	0.04390	0.003330	4.38e-02	9.90e-01	8.65e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	12	9.31e-01	9.51e-01	0.04390	-0.031200	-3.09e-02	8.52e-01	8.53e-01
Signaling by ERBB2	44	8.77e-01	9.14e-01	0.04330	0.009540	-4.23e-02	9.13e-01	6.28e-01
RUNX2 regulates osteoblast differentiation	16	9.55e-01	9.67e-01	0.04320	0.041900	-1.07e-02	7.72e-01	9.41e-01
Signaling by NODAL	15	9.61e-01	9.70e-01	0.04270	-0.012500	4.08e-02	9.33e-01	7.84e-01
NOD1/2 Signaling Pathway	36	9.08e-01	9.35e-01	0.04250	0.011800	-4.09e-02	9.03e-01	6.71e-01
GABA synthesis, release, reuptake and degradation	12	9.39e-01	9.57e-01	0.04210	-0.021800	-3.60e-02	8.96e-01	8.29e-01
Metabolism of vitamins and cofactors	163	4.63e-01	5.79e-01	0.04090	-0.017200	-3.71e-02	7.05e-01	4.13e-01
Effects of PIP2 hydrolysis	24	9.61e-01	9.70e-01	0.04070	-0.026900	3.06e-02	8.20e-01	7.95e-01
FLT3 signaling through SRC family kinases	6	9.83e-01	9.88e-01	0.03940	0.003590	-3.92e-02	9.88e-01	8.68e-01
Chromatin modifying enzymes	213	5.64e-01	6.63e-01	0.03930	0.039000	-5.32e-03	3.27e-01	8.94e-01
Chromatin organization	213	5.64e-01	6.63e-01	0.03930	0.039000	-5.32e-03	3.27e-01	8.94e-01
Iron uptake and transport	52	9.13e-01	9.37e-01	0.03930	0.019300	-3.42e-02	8.09e-01	6.70e-01
Diseases of metabolism	198	7.24e-01	7.96e-01	0.03890	-0.032800	2.11e-02	4.27e-01	6.09e-01
HCMV Late Events	67	7.82e-01	8.46e-01	0.03870	-0.037900	-7.88e-03	5.92e-01	9.11e-01
Glutamate and glutamine metabolism	12	9.47e-01	9.61e-01	0.03840	-0.029700	-2.43e-02	8.59e-01	8.84e-01
Signaling by FGFR	73	7.29e-01	8.00e-01	0.03790	-0.030800	-2.20e-02	6.49e-01	7.45e-01
SUMOylation	167	5.08e-01	6.18e-01	0.03670	-0.021700	-2.96e-02	6.28e-01	5.10e-01
Lysosphingolipid and LPA receptors	11	9.85e-01	9.89e-01	0.03650	0.029500	-2.16e-02	8.66e-01	9.01e-01
Amino acids regulate mTORC1	48	8.32e-01	8.82e-01	0.03520	0.025500	2.43e-02	7.60e-01	7.71e-01
Metabolism of carbohydrates	236	6.02e-01	6.96e-01	0.03520	0.034900	-4.82e-03	3.56e-01	8.99e-01
Diseases of programmed cell death	58	8.06e-01	8.64e-01	0.03490	-0.027300	-2.17e-02	7.20e-01	7.75e-01
TNFR1-induced NF-kappa-B signaling pathway	32	8.97e-01	9.27e-01	0.03460	-0.014200	-3.16e-02	8.89e-01	7.57e-01
Synthesis of substrates in N-glycan biosythesis	58	9.08e-01	9.35e-01	0.03360	-0.032300	9.35e-03	6.71e-01	9.02e-01
Glycosphingolipid metabolism	47	9.40e-01	9.57e-01	0.03350	0.029700	-1.56e-02	7.25e-01	8.54e-01
CD28 co-stimulation	33	9.02e-01	9.31e-01	0.03240	-0.017300	-2.74e-02	8.64e-01	7.85e-01
Unfolded Protein Response (UPR)	84	9.15e-01	9.37e-01	0.03200	0.018900	-2.58e-02	7.65e-01	6.83e-01
Metabolism of steroid hormones	21	9.40e-01	9.57e-01	0.03180	0.014900	2.81e-02	9.06e-01	8.23e-01
HATs acetylate histones	92	9.10e-01	9.35e-01	0.03070	-0.026000	1.63e-02	6.66e-01	7.87e-01
Transcriptional and post-translational regulation of MITF-M expression and activity	36	9.33e-01	9.52e-01	0.02870	-0.028400	-4.20e-03	7.68e-01	9.65e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	21	9.72e-01	9.78e-01	0.02810	0.004380	-2.77e-02	9.72e-01	8.26e-01
SHC-mediated cascade:FGFR1	13	9.90e-01	9.93e-01	0.02750	0.022800	-1.53e-02	8.87e-01	9.24e-01
B-WICH complex positively regulates rRNA expression	45	9.68e-01	9.75e-01	0.02670	-0.016400	2.10e-02	8.49e-01	8.07e-01
Transcriptional regulation of brown and beige adipocyte differentiation	23	9.59e-01	9.70e-01	0.02580	0.023900	9.61e-03	8.42e-01	9.36e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	23	9.59e-01	9.70e-01	0.02580	0.023900	9.61e-03	8.42e-01	9.36e-01
Glycerophospholipid biosynthesis	104	8.90e-01	9.25e-01	0.02430	0.001530	-2.42e-02	9.79e-01	6.69e-01
TAK1-dependent IKK and NF-kappa-B activation	43	9.47e-01	9.61e-01	0.02400	0.024000	1.72e-03	7.86e-01	9.84e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	9.70e-01	9.76e-01	0.02360	0.005010	2.31e-02	9.68e-01	8.51e-01
SUMO E3 ligases SUMOylate target proteins	161	8.49e-01	8.93e-01	0.01930	-0.006770	-1.81e-02	8.82e-01	6.92e-01
Histidine catabolism	7	9.98e-01	9.99e-01	0.01890	0.014300	-1.24e-02	9.48e-01	9.55e-01
Phospholipase C-mediated cascade; FGFR2	8	9.98e-01	9.99e-01	0.01420	0.011200	-8.72e-03	9.56e-01	9.66e-01
Synthesis of PC	23	9.92e-01	9.95e-01	0.01100	-0.007310	-8.18e-03	9.52e-01	9.46e-01
ERK/MAPK targets	22	9.96e-01	9.98e-01	0.00973	-0.000257	-9.73e-03	9.98e-01	9.37e-01
CD209 (DC-SIGN) signaling	20	9.99e-01	9.99e-01	0.00620	0.001540	-6.00e-03	9.90e-01	9.63e-01
Activation of BAD and translocation to mitochondria	15	9.99e-01	9.99e-01	0.00619	-0.003570	5.05e-03	9.81e-01	9.73e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	7	9.99e-01	9.99e-01	0.00588	0.002540	5.30e-03	9.91e-01	9.81e-01

---

Detailed Gene set reports

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

metric	value
setSize	6
pMANOVA	0.00164
p.adjustMANOVA	0.00875
s.dist	1.02
s.crp_pod1_adj	0.814
s.dex_pod1_adj	-0.61
p.crp_pod1_adj	0.000554
p.dex_pod1_adj	0.00964

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
H19	9980	-11004
IGF2BP3	9845	-10911
CD44	8699	-10680
ACTB	7610	-7382
MYC	8860	-4670

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
ACTB	7610	-7382
CD44	8699	-10680
H19	9980	-11004
IGF2BP2	5157	3333
IGF2BP3	9845	-10911
MYC	8860	-4670

---

---

Response to metal ions

Response to metal ions

metric	value
setSize	6
pMANOVA	0.00202
p.adjustMANOVA	0.0103
s.dist	1.01
s.crp_pod1_adj	0.774
s.dex_pod1_adj	-0.657
p.crp_pod1_adj	0.00103
p.dex_pod1_adj	0.00535

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
MTF1	9776	-8963
MT1X	9137	-9543
MT2A	8856	-5340
MT1E	8758	-4932
CSRP1	5131	-8366
MT1F	5937	-7121

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CSRP1	5131	-8366
MT1E	8758	-4932
MT1F	5937	-7121
MT1X	9137	-9543
MT2A	8856	-5340
MTF1	9776	-8963

---

---

G2/M DNA replication checkpoint

G2/M DNA replication checkpoint

metric	value
setSize	5
pMANOVA	0.00983
p.adjustMANOVA	0.0372
s.dist	0.966
s.crp_pod1_adj	0.692
s.dex_pod1_adj	-0.675
p.crp_pod1_adj	0.0074
p.dex_pod1_adj	0.00899

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
CDK1	8897	-10879
CCNB1	7371	-10137
CCNB2	5317	-9036
PKMYT1	6505	-4319
WEE1	7202	-3477

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CCNB1	7371	-10137
CCNB2	5317	-9036
CDK1	8897	-10879
PKMYT1	6505	-4319
WEE1	7202	-3477

---

---

Fructose metabolism

Fructose metabolism

metric	value
setSize	7
pMANOVA	0.00281
p.adjustMANOVA	0.0135
s.dist	0.912
s.crp_pod1_adj	-0.581
s.dex_pod1_adj	0.703
p.crp_pod1_adj	0.00778
p.dex_pod1_adj	0.00127

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
ALDH1A1	-10915	10191
TKFC	-10688	10041
AKR1B1	-10849	9594
KHK	-10573	9275
SORD	-7095	6388

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
AKR1B1	-10849	9594
ALDH1A1	-10915	10191
ALDOB	2371	-66
GLYCTK	2531	4047
KHK	-10573	9275
SORD	-7095	6388
TKFC	-10688	10041

---

---

CD163 mediating an anti-inflammatory response

CD163 mediating an anti-inflammatory response

metric	value
setSize	8
pMANOVA	1.61e-06
p.adjustMANOVA	2.07e-05
s.dist	0.875
s.crp_pod1_adj	0.873
s.dex_pod1_adj	0.0579
p.crp_pod1_adj	1.91e-05
p.dex_pod1_adj	0.777

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
CD163	8710	8968
PLK2	7307	8558
RHBDF2	8363	3428

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
ADAM17	9123	-920
CD163	8710	8968
FURIN	9787	-270
IL10	9783	-1000
MAPK14	10146	-10642
MYH9	8624	-6428
PLK2	7307	8558
RHBDF2	8363	3428

---

---

Butyrophilin (BTN) family interactions

Butyrophilin (BTN) family interactions

metric	value
setSize	10
pMANOVA	0.000772
p.adjustMANOVA	0.00451
s.dist	0.849
s.crp_pod1_adj	-0.575
s.dex_pod1_adj	0.625
p.crp_pod1_adj	0.00164
p.dex_pod1_adj	0.000621

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
BTN2A2	-10892	10074
BTN3A1	-10808	9859
BTN2A1	-10543	9340
CD209	-10416	7737
BTN3A3	-7390	5904
BTN3A2	-7555	2904
BTN1A1	-7516	1752

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
BTN1A1	-7516	1752
BTN2A1	-10543	9340
BTN2A2	-10892	10074
BTN3A1	-10808	9859
BTN3A2	-7555	2904
BTN3A3	-7390	5904
BTNL8	2440	9199
BTNL9	-5641	-1019
CD209	-10416	7737
PPL	4345	6597

---

---

Activation of NIMA Kinases NEK9, NEK6, NEK7

Activation of NIMA Kinases NEK9, NEK6, NEK7

metric	value
setSize	7
pMANOVA	0.00457
p.adjustMANOVA	0.0199
s.dist	0.843
s.crp_pod1_adj	0.456
s.dex_pod1_adj	-0.708
p.crp_pod1_adj	0.0365
p.dex_pod1_adj	0.00117

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
CDK1	8897	-10879
CCNB1	7371	-10137
NEK9	6394	-9603
CCNB2	5317	-9036
PLK1	5990	-6724
NEK6	1416	-320

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CCNB1	7371	-10137
CCNB2	5317	-9036
CDK1	8897	-10879
NEK6	1416	-320
NEK7	-3474	-8805
NEK9	6394	-9603
PLK1	5990	-6724

---

---

Fructose catabolism

Fructose catabolism

metric	value
setSize	5
pMANOVA	0.0286
p.adjustMANOVA	0.0821
s.dist	0.827
s.crp_pod1_adj	-0.486
s.dex_pod1_adj	0.668
p.crp_pod1_adj	0.0597
p.dex_pod1_adj	0.00965

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
ALDH1A1	-10915	10191
TKFC	-10688	10041
KHK	-10573	9275

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
ALDH1A1	-10915	10191
ALDOB	2371	-66
GLYCTK	2531	4047
KHK	-10573	9275
TKFC	-10688	10041

---

---

Regulation of IFNA/IFNB signaling

Regulation of IFNA/IFNB signaling

metric	value
setSize	12
pMANOVA	0.000203
p.adjustMANOVA	0.00145
s.dist	0.81
s.crp_pod1_adj	0.441
s.dex_pod1_adj	-0.679
p.crp_pod1_adj	0.0082
p.dex_pod1_adj	4.63e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
SOCS3	10320	-10421
PTPN1	10157	-10313
IFNAR2	9716	-10357
SOCS1	10000	-9115
IFNAR1	7766	-10332
PTPN11	8724	-8706
JAK1	4194	-9176
PTPN6	7569	-4480

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
IFNAR1	7766	-10332
IFNAR2	9716	-10357
JAK1	4194	-9176
PTPN1	10157	-10313
PTPN11	8724	-8706
PTPN6	7569	-4480
SOCS1	10000	-9115
SOCS3	10320	-10421
STAT1	-2834	-10928
STAT2	-5596	-7381
TYK2	-448	8655
USP18	-6868	-8824

---

---

Type I hemidesmosome assembly

Type I hemidesmosome assembly

metric	value
setSize	8
pMANOVA	0.00583
p.adjustMANOVA	0.0236
s.dist	0.806
s.crp_pod1_adj	0.566
s.dex_pod1_adj	-0.574
p.crp_pod1_adj	0.0056
p.dex_pod1_adj	0.00492

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
LAMB3	10197	-10945
ITGA6	9799	-9695
KRT5	8074	-11029
COL17A1	9113	-9228
PLEC	8552	-529
CD151	3763	-1131
ITGB4	61	-5191

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CD151	3763	-1131
COL17A1	9113	-9228
DST	-3812	-4269
ITGA6	9799	-9695
ITGB4	61	-5191
KRT5	8074	-11029
LAMB3	10197	-10945
PLEC	8552	-529

---

---

Activation of caspases through apoptosome-mediated cleavage

Activation of caspases through apoptosome-mediated cleavage

metric	value
setSize	6
pMANOVA	0.00183
p.adjustMANOVA	0.00957
s.dist	0.794
s.crp_pod1_adj	0.144
s.dex_pod1_adj	-0.781
p.crp_pod1_adj	0.542
p.dex_pod1_adj	0.000926

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
XIAP	3594	-10076
CASP3	2378	-10564
CASP9	1584	-9502
CYCS	2365	-5790
APAF1	519	-8943

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
APAF1	519	-8943
CASP3	2378	-10564
CASP7	-3016	-7309
CASP9	1584	-9502
CYCS	2365	-5790
XIAP	3594	-10076

---

---

Inhibition of Signaling by Overexpressed EGFR

Inhibition of Signaling by Overexpressed EGFR

metric	value
setSize	5
pMANOVA	0.000408
p.adjustMANOVA	0.00259
s.dist	0.78
s.crp_pod1_adj	0.753
s.dex_pod1_adj	0.202
p.crp_pod1_adj	0.00354
p.dex_pod1_adj	0.433

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
AREG	9309	9303
EREG	9520	8807
HBEGF	8211	2495

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
AREG	9309	9303
EGF	1257	-950
EREG	9520	8807
HBEGF	8211	2495
TGFA	10260	-10921

---

---

Signaling by Overexpressed Wild-Type EGFR in Cancer

Signaling by Overexpressed Wild-Type EGFR in Cancer

metric	value
setSize	5
pMANOVA	0.000408
p.adjustMANOVA	0.00259
s.dist	0.78
s.crp_pod1_adj	0.753
s.dex_pod1_adj	0.202
p.crp_pod1_adj	0.00354
p.dex_pod1_adj	0.433

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
AREG	9309	9303
EREG	9520	8807
HBEGF	8211	2495

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
AREG	9309	9303
EGF	1257	-950
EREG	9520	8807
HBEGF	8211	2495
TGFA	10260	-10921

---

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

metric	value
setSize	11
pMANOVA	0.000391
p.adjustMANOVA	0.00254
s.dist	0.77
s.crp_pod1_adj	0.344
s.dex_pod1_adj	-0.69
p.crp_pod1_adj	0.0484
p.dex_pod1_adj	7.48e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
PDS5A	7491	-9186
ESCO2	6015	-10349
CDCA5	5346	-9972
STAG2	4920	-8933
SMC1A	7014	-4346
STAG1	2355	-7923
RAD21	2757	-6485
WAPL	1716	-7805
SMC3	1410	-8596
PDS5B	418	-2072

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CDCA5	5346	-9972
ESCO1	-2461	-9325
ESCO2	6015	-10349
PDS5A	7491	-9186
PDS5B	418	-2072
RAD21	2757	-6485
SMC1A	7014	-4346
SMC3	1410	-8596
STAG1	2355	-7923
STAG2	4920	-8933
WAPL	1716	-7805

---

---

Maturation of protein 3a_9683673

Maturation of protein 3a_9683673

metric	value
setSize	9
pMANOVA	0.00445
p.adjustMANOVA	0.0195
s.dist	0.762
s.crp_pod1_adj	0.454
s.dex_pod1_adj	-0.612
p.crp_pod1_adj	0.0184
p.dex_pod1_adj	0.00146

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
ST6GALNAC3	9453	-9647
ST3GAL2	9439	-9254
ST3GAL4	8037	-9937
ST3GAL1	7899	-5684
GALNT1	3114	-10568
ST6GAL1	3630	-5289
ST3GAL3	2068	-2695

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
GALNT1	3114	-10568
ST3GAL1	7899	-5684
ST3GAL2	9439	-9254
ST3GAL3	2068	-2695
ST3GAL4	8037	-9937
ST6GAL1	3630	-5289
ST6GALNAC2	-1795	-6954
ST6GALNAC3	9453	-9647
ST6GALNAC4	-1070	-2150

---

---

Maturation of protein 3a_9694719

Maturation of protein 3a_9694719

metric	value
setSize	9
pMANOVA	0.00445
p.adjustMANOVA	0.0195
s.dist	0.762
s.crp_pod1_adj	0.454
s.dex_pod1_adj	-0.612
p.crp_pod1_adj	0.0184
p.dex_pod1_adj	0.00146

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
ST6GALNAC3	9453	-9647
ST3GAL2	9439	-9254
ST3GAL4	8037	-9937
ST3GAL1	7899	-5684
GALNT1	3114	-10568
ST6GAL1	3630	-5289
ST3GAL3	2068	-2695

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
GALNT1	3114	-10568
ST3GAL1	7899	-5684
ST3GAL2	9439	-9254
ST3GAL3	2068	-2695
ST3GAL4	8037	-9937
ST6GAL1	3630	-5289
ST6GALNAC2	-1795	-6954
ST6GALNAC3	9453	-9647
ST6GALNAC4	-1070	-2150

---

---

ARMS-mediated activation

ARMS-mediated activation

metric	value
setSize	6
pMANOVA	0.0164
p.adjustMANOVA	0.0539
s.dist	0.762
s.crp_pod1_adj	0.351
s.dex_pod1_adj	-0.676
p.crp_pod1_adj	0.136
p.dex_pod1_adj	0.00415

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
NTRK1	9393	-10996
KIDINS220	6125	-7453
BRAF	2325	-5960
CRK	2710	-4174
YWHAB	861	-9769

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
BRAF	2325	-5960
CRK	2710	-4174
KIDINS220	6125	-7453
NTRK1	9393	-10996
RAP1A	-749	-7134
YWHAB	861	-9769

---

---

Acetylcholine binding and downstream events

Acetylcholine binding and downstream events

metric	value
setSize	5
pMANOVA	0.0436
p.adjustMANOVA	0.112
s.dist	0.759
s.crp_pod1_adj	0.64
s.dex_pod1_adj	-0.409
p.crp_pod1_adj	0.0133
p.dex_pod1_adj	0.114

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
CHRNA7	4919	-8960
CHRNA5	5114	-8553
CHRNE	4721	-5805
CHRNA2	8983	-2764

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CHRNA2	8983	-2764
CHRNA5	5114	-8553
CHRNA7	4919	-8960
CHRNB2	8794	2363
CHRNE	4721	-5805

---

---

Postsynaptic nicotinic acetylcholine receptors

Postsynaptic nicotinic acetylcholine receptors

metric	value
setSize	5
pMANOVA	0.0436
p.adjustMANOVA	0.112
s.dist	0.759
s.crp_pod1_adj	0.64
s.dex_pod1_adj	-0.409
p.crp_pod1_adj	0.0133
p.dex_pod1_adj	0.114

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
CHRNA7	4919	-8960
CHRNA5	5114	-8553
CHRNE	4721	-5805
CHRNA2	8983	-2764

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CHRNA2	8983	-2764
CHRNA5	5114	-8553
CHRNA7	4919	-8960
CHRNB2	8794	2363
CHRNE	4721	-5805

---

---

Neurotransmitter clearance

Neurotransmitter clearance

metric	value
setSize	6
pMANOVA	0.00546
p.adjustMANOVA	0.0225
s.dist	0.755
s.crp_pod1_adj	-0.192
s.dex_pod1_adj	0.73
p.crp_pod1_adj	0.416
p.dex_pod1_adj	0.00196

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
ALDH2	-7135	10010
LRTOMT	-6927	7629
COMT	-7796	6626
MAOA	-1422	10060

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
ALDH2	-7135	10010
COMT	-7796	6626
LRTOMT	-6927	7629
MAOA	-1422	10060
SLC22A1	3933	9883
SLC6A4	5398	-95

---

---

Protein repair

Protein repair

metric	value
setSize	6
pMANOVA	0.0226
p.adjustMANOVA	0.0683
s.dist	0.751
s.crp_pod1_adj	0.382
s.dex_pod1_adj	-0.646
p.crp_pod1_adj	0.105
p.dex_pod1_adj	0.0061

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
MSRB3	8104	-8247
PCMT1	6266	-9732
MSRB1	7547	-7661
TXN	6040	-9485

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
MSRA	-937	-9728
MSRB1	7547	-7661
MSRB2	-4374	1227
MSRB3	8104	-8247
PCMT1	6266	-9732
TXN	6040	-9485

---

---

Formation of xylulose-5-phosphate

Formation of xylulose-5-phosphate

metric	value
setSize	5
pMANOVA	0.0156
p.adjustMANOVA	0.0521
s.dist	0.75
s.crp_pod1_adj	-0.72
s.dex_pod1_adj	0.209
p.crp_pod1_adj	0.00528
p.dex_pod1_adj	0.418

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
AKR1A1	-7217	6320
SORD	-7095	6388

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
AKR1A1	-7217	6320
CRYL1	-9133	-484
DCXR	-6143	-2808
SORD	-7095	6388
XYLB	-10123	-325

---

---

Synthesis of diphthamide-EEF2

Synthesis of diphthamide-EEF2

metric	value
setSize	8
pMANOVA	0.00719
p.adjustMANOVA	0.0283
s.dist	0.748
s.crp_pod1_adj	-0.637
s.dex_pod1_adj	0.393
p.crp_pod1_adj	0.00181
p.dex_pod1_adj	0.0541

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
DPH7	-9744	10156
DPH6	-10840	8561
EEF2	-9782	8829
DPH1	-8654	8672
DPH2	-8411	8877
DNAJC24	-10560	4185

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
DNAJC24	-10560	4185
DPH1	-8654	8672
DPH2	-8411	8877
DPH3	5248	-10252
DPH5	-3684	-8833
DPH6	-10840	8561
DPH7	-9744	10156
EEF2	-9782	8829

---

---

NFE2L2 regulates pentose phosphate pathway genes

NFE2L2 regulates pentose phosphate pathway genes

metric	value
setSize	8
pMANOVA	0.00197
p.adjustMANOVA	0.0102
s.dist	0.734
s.crp_pod1_adj	0.701
s.dex_pod1_adj	-0.218
p.crp_pod1_adj	0.000594
p.dex_pod1_adj	0.285

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
PGD	10160	-10473
G6PD	8982	-4583
MAFG	9975	-1447
TALDO1	3057	-3963
TKT	4470	-1824
CREBBP	9117	-213
EP300	8092	-17

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CREBBP	9117	-213
EP300	8092	-17
G6PD	8982	-4583
MAFG	9975	-1447
NFE2L2	3414	745
PGD	10160	-10473
TALDO1	3057	-3963
TKT	4470	-1824

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	100
pMANOVA	4.01e-32
p.adjustMANOVA	1.28e-29
s.dist	0.733
s.crp_pod1_adj	-0.686
s.dex_pod1_adj	0.258
p.crp_pod1_adj	1.71e-32
p.dex_pod1_adj	8.4e-06

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
EIF3B	-7939	9565
EIF3L	-10568	7038
RPL29	-9905	7249
EIF3F	-8955	8003
EIF3G	-8914	7623
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049
RPL26	-9580	4662

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF1AX	-4224	-3200
EIF3A	-5698	1014
EIF3B	-7939	9565
EIF3C	-7727	4981
EIF3D	-8646	2351
EIF3E	-9990	1992
EIF3F	-8955	8003
EIF3G	-8914	7623
EIF3H	-8454	1953
EIF3I	-5939	-1862
EIF3J	-6194	-9052
EIF3K	-8872	3993
EIF3L	-10568	7038
EIF3M	-10593	2961
FAU	-7843	4785
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	88
pMANOVA	4.69e-28
p.adjustMANOVA	6.44e-26
s.dist	0.732
s.crp_pod1_adj	-0.683
s.dex_pod1_adj	0.263
p.crp_pod1_adj	1.39e-28
p.dex_pod1_adj	2.05e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
EEF2	-9782	8829
RPL29	-9905	7249
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EEF1A1	-10245	5370
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049
RPL26	-9580	4662
RPL30	-8665	4966
RPL39	-8078	5174

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EEF1A1	-10245	5370
EEF2	-9782	8829
FAU	-7843	4785
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Interleukin-21 signaling

Interleukin-21 signaling

metric	value
setSize	9
pMANOVA	0.00295
p.adjustMANOVA	0.0139
s.dist	0.731
s.crp_pod1_adj	0.321
s.dex_pod1_adj	-0.657
p.crp_pod1_adj	0.0958
p.dex_pod1_adj	0.000645

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
JAK3	10262	-10659
IL21R	9601	-10243
STAT3	9918	-9901
JAK1	4194	-9176
STAT5B	3275	-3345

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
IL21R	9601	-10243
IL2RG	-3583	-8059
JAK1	4194	-9176
JAK3	10262	-10659
STAT1	-2834	-10928
STAT3	9918	-9901
STAT4	-4500	-6553
STAT5A	1714	2457
STAT5B	3275	-3345

---

---

Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis

metric	value
setSize	13
pMANOVA	0.00104
p.adjustMANOVA	0.00583
s.dist	0.721
s.crp_pod1_adj	0.448
s.dex_pod1_adj	-0.565
p.crp_pod1_adj	0.00516
p.dex_pod1_adj	0.000421

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
KIF20A	8698	-10170
PDS5A	7491	-9186
NIPBL	6805	-8207
STAG2	4920	-8933
PLK1	5990	-6724
SMC1A	7014	-4346
KIF23	4862	-5801
STAG1	2355	-7923
RAD21	2757	-6485
WAPL	1716	-7805
SMC3	1410	-8596
PDS5B	418	-2072

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
KIF20A	8698	-10170
KIF23	4862	-5801
MAU2	3650	3035
NIPBL	6805	-8207
PDS5A	7491	-9186
PDS5B	418	-2072
PLK1	5990	-6724
RAD21	2757	-6485
SMC1A	7014	-4346
SMC3	1410	-8596
STAG1	2355	-7923
STAG2	4920	-8933
WAPL	1716	-7805

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	93
pMANOVA	1.13e-28
p.adjustMANOVA	1.82e-26
s.dist	0.718
s.crp_pod1_adj	-0.671
s.dex_pod1_adj	0.254
p.crp_pod1_adj	3.94e-29
p.dex_pod1_adj	2.31e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
EEF2	-9782	8829
RPL29	-9905	7249
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EEF1A1	-10245	5370
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049
RPL26	-9580	4662
RPL30	-8665	4966
RPL39	-8078	5174

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EEF1A1	-10245	5370
EEF1A1P5	-9368	1606
EEF1A2	4434	-3247
EEF1B2	-8023	1755
EEF1D	-6126	2739
EEF1G	-6690	354
EEF2	-9782	8829
FAU	-7843	4785
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	92
pMANOVA	5.12e-28
p.adjustMANOVA	6.55e-26
s.dist	0.711
s.crp_pod1_adj	-0.666
s.dex_pod1_adj	0.248
p.crp_pod1_adj	2.01e-28
p.dex_pod1_adj	4.03e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
RPL29	-9905	7249
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
SEPSECS	-9022	5257
RPL18A	-8223	5644
RPL15	-8846	5049
RPL26	-9580	4662
RPL30	-8665	4966
RPL39	-8078	5174
RPL38	-7530	5206

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EEFSEC	-5940	6579
FAU	-7843	4785
PSTK	-6973	1015
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
SARS1	-6275	268
SECISBP2	-9328	4054
SEPHS2	4069	-8150
SEPSECS	-9022	5257
UBA52	-8729	4310

---

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

metric	value
setSize	36
pMANOVA	5.44e-11
p.adjustMANOVA	1.29e-09
s.dist	0.708
s.crp_pod1_adj	-0.656
s.dex_pod1_adj	0.266
p.crp_pod1_adj	9.11e-12
p.dex_pod1_adj	0.00574

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EEF1A1	-10245	5370
RPS2	-7645	6571
RPS16	-7012	6858
FAU	-7843	4785
RPS28	-7102	4935
RPS15	-7592	4426
RPS10	-8578	3553
RPS3	-9260	3262
RPS20	-9206	2822
RPS5	-5787	4159
RPS3A	-9507	2361
RPS23	-7122	2907
RPS27A	-8697	1977
RPS21	-6334	2297
RPS18	-6316	1926

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EEF1A1	-10245	5370
FAU	-7843	4785
HNRNPA1	-7206	1351
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	88
pMANOVA	2.31e-26
p.adjustMANOVA	2.11e-24
s.dist	0.697
s.crp_pod1_adj	-0.658
s.dex_pod1_adj	0.232
p.crp_pod1_adj	1.31e-26
p.dex_pod1_adj	0.000168

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
RPL29	-9905	7249
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049
RPL26	-9580	4662
RPL30	-8665	4966
RPL39	-8078	5174
RPL38	-7530	5206
UBA52	-8729	4310

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
DNAJC3	10014	-9983
FAU	-7843	4785
GRSF1	-6338	-4335
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	92
pMANOVA	2.94e-27
p.adjustMANOVA	3.14e-25
s.dist	0.694
s.crp_pod1_adj	-0.655
s.dex_pod1_adj	0.232
p.crp_pod1_adj	1.7e-27
p.dex_pod1_adj	0.000121

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
RPL29	-9905	7249
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
N6AMT1	-9592	4703
RPL15	-8846	5049
RPL26	-9580	4662
RPL30	-8665	4966
RPL39	-8078	5174
RPL38	-7530	5206

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
APEH	-5934	4399
ETF1	1864	-2843
FAU	-7843	4785
GSPT1	2489	-4986
GSPT2	-4177	-8081
N6AMT1	-9592	4703
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
TRMT112	-6824	466
UBA52	-8729	4310

---

---

EGFR interacts with phospholipase C-gamma

EGFR interacts with phospholipase C-gamma

metric	value
setSize	6
pMANOVA	0.00045
p.adjustMANOVA	0.00285
s.dist	0.692
s.crp_pod1_adj	0.655
s.dex_pod1_adj	0.224
p.crp_pod1_adj	0.00549
p.dex_pod1_adj	0.342

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
AREG	9309	9303
EREG	9520	8807
HBEGF	8211	2495
PLCG1	1429	3116

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
AREG	9309	9303
EGF	1257	-950
EREG	9520	8807
HBEGF	8211	2495
PLCG1	1429	3116
TGFA	10260	-10921

---

---

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

metric	value
setSize	5
pMANOVA	0.0884
p.adjustMANOVA	0.187
s.dist	0.688
s.crp_pod1_adj	0.418
s.dex_pod1_adj	-0.546
p.crp_pod1_adj	0.106
p.dex_pod1_adj	0.0345

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
GAS6	10268	-10292
PROC	6087	-10372
PROS1	5796	-9524
PROZ	3237	-940

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
BGLAP	-4631	115
GAS6	10268	-10292
PROC	6087	-10372
PROS1	5796	-9524
PROZ	3237	-940

---

---

Platelet sensitization by LDL

Platelet sensitization by LDL

metric	value
setSize	16
pMANOVA	0.00052
p.adjustMANOVA	0.00318
s.dist	0.685
s.crp_pod1_adj	0.436
s.dex_pod1_adj	-0.527
p.crp_pod1_adj	0.0025
p.dex_pod1_adj	0.000259

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
MAPK14	10146	-10642
FGR	10011	-10342
LRP8	10221	-7521
PTPN11	8724	-8706
PECAM1	4394	-9655
PTPN6	7569	-4480
PPP2R1B	4670	-6069
PPP2CA	3126	-7332
PPP2R5A	3065	-7028
PPP2R5E	3522	-5368
PLA2G4A	7100	-2553
PPP2R5D	3887	-3700
PPP2R5B	6606	-1596

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
FGR	10011	-10342
LRP8	10221	-7521
MAPK14	10146	-10642
PECAM1	4394	-9655
PLA2G4A	7100	-2553
PPP2CA	3126	-7332
PPP2CB	-5595	-3552
PPP2R1A	-2420	-962
PPP2R1B	4670	-6069
PPP2R5A	3065	-7028
PPP2R5B	6606	-1596
PPP2R5C	-5494	-6556
PPP2R5D	3887	-3700
PPP2R5E	3522	-5368
PTPN11	8724	-8706
PTPN6	7569	-4480

---

---

RUNX3 regulates CDKN1A transcription

RUNX3 regulates CDKN1A transcription

metric	value
setSize	7
pMANOVA	0.0302
p.adjustMANOVA	0.0862
s.dist	0.685
s.crp_pod1_adj	-0.383
s.dex_pod1_adj	0.568
p.crp_pod1_adj	0.0795
p.dex_pod1_adj	0.0093

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
TP53	-10249	9052
SMAD3	-7857	9753
TGFB1	-8343	7345
ZFHX3	-5156	8883

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CDKN1A	6185	8619
RUNX3	259	1164
SMAD3	-7857	9753
SMAD4	-5325	-5430
TGFB1	-8343	7345
TP53	-10249	9052
ZFHX3	-5156	8883

---

---

Interleukin-6 signaling

Interleukin-6 signaling

metric	value
setSize	10
pMANOVA	0.00473
p.adjustMANOVA	0.0204
s.dist	0.683
s.crp_pod1_adj	0.332
s.dex_pod1_adj	-0.597
p.crp_pod1_adj	0.069
p.dex_pod1_adj	0.00108

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
SOCS3	10320	-10421
STAT3	9918	-9901
IL6ST	7943	-10319
PTPN11	8724	-8706
JAK1	4194	-9176
CBL	4108	-6596

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CBL	4108	-6596
IL6R	-2315	-5911
IL6ST	7943	-10319
JAK1	4194	-9176
JAK2	-7227	-4114
PTPN11	8724	-8706
SOCS3	10320	-10421
STAT1	-2834	-10928
STAT3	9918	-9901
TYK2	-448	8655

---

---

RUNX1 regulates transcription of genes involved in BCR signaling

RUNX1 regulates transcription of genes involved in BCR signaling

metric	value
setSize	6
pMANOVA	0.0428
p.adjustMANOVA	0.111
s.dist	0.682
s.crp_pod1_adj	0.59
s.dex_pod1_adj	-0.342
p.crp_pod1_adj	0.0123
p.dex_pod1_adj	0.147

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RUNX1	10315	-10752
CBFB	4970	-9467
PAX5	7274	-1626
ELF1	1383	-4733
ELF2	4102	-1174

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
BLK	7828	3516
CBFB	4970	-9467
ELF1	1383	-4733
ELF2	4102	-1174
PAX5	7274	-1626
RUNX1	10315	-10752

---

---

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Removal of aminoterminal propeptides from gamma-carboxylated proteins

metric	value
setSize	6
pMANOVA	0.0633
p.adjustMANOVA	0.147
s.dist	0.679
s.crp_pod1_adj	0.506
s.dex_pod1_adj	-0.453
p.crp_pod1_adj	0.0317
p.dex_pod1_adj	0.0547

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
GAS6	10268	-10292
PROC	6087	-10372
PROS1	5796	-9524
PROZ	3237	-940
FURIN	9787	-270

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
BGLAP	-4631	115
FURIN	9787	-270
GAS6	10268	-10292
PROC	6087	-10372
PROS1	5796	-9524
PROZ	3237	-940

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	94
pMANOVA	2.97e-26
p.adjustMANOVA	2.59e-24
s.dist	0.679
s.crp_pod1_adj	-0.637
s.dex_pod1_adj	0.235
p.crp_pod1_adj	1.16e-26
p.dex_pod1_adj	8.33e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
NCBP2	-10422	9779
RPS4Y1	-9472	9683
RPL29	-9905	7249
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049
RPL26	-9580	4662
RPL30	-8665	4966
RPL39	-8078	5174
RPL38	-7530	5206

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF4G1	9201	2288
ETF1	1864	-2843
FAU	-7843	4785
GSPT1	2489	-4986
GSPT2	-4177	-8081
NCBP1	-6313	1777
NCBP2	-10422	9779
PABPC1	-10239	-2209
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310
UPF1	-1566	4928

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	110
pMANOVA	1.92e-31
p.adjustMANOVA	4.09e-29
s.dist	0.679
s.crp_pod1_adj	-0.642
s.dex_pod1_adj	0.219
p.crp_pod1_adj	2.14e-31
p.dex_pod1_adj	7.2e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
EIF3B	-7939	9565
EIF3L	-10568	7038
RPL29	-9905	7249
EIF3F	-8955	8003
EIF3G	-8914	7623
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EIF4A1	-6442	8203
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF1AX	-4224	-3200
EIF2S1	1134	-7680
EIF2S2	1009	-8896
EIF2S3	-8440	-5447
EIF3A	-5698	1014
EIF3B	-7939	9565
EIF3C	-7727	4981
EIF3D	-8646	2351
EIF3E	-9990	1992
EIF3F	-8955	8003
EIF3G	-8914	7623
EIF3H	-8454	1953
EIF3I	-5939	-1862
EIF3J	-6194	-9052
EIF3K	-8872	3993
EIF3L	-10568	7038
EIF3M	-10593	2961
EIF4A1	-6442	8203
EIF4A2	-6158	-560
EIF4B	-10332	2485
EIF4E	7774	-9579
EIF4G1	9201	2288
EIF4H	-1997	-515
FAU	-7843	4785
PABPC1	-10239	-2209
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

metric	value
setSize	51
pMANOVA	4.4e-15
p.adjustMANOVA	1.76e-13
s.dist	0.679
s.crp_pod1_adj	-0.644
s.dex_pod1_adj	0.215
p.crp_pod1_adj	1.77e-15
p.dex_pod1_adj	0.00789

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
EIF3B	-7939	9565
EIF3L	-10568	7038
EIF3F	-8955	8003
EIF3G	-8914	7623
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
RPS2	-7645	6571
RPS16	-7012	6858
EIF3C	-7727	4981
FAU	-7843	4785
EIF3K	-8872	3993
RPS28	-7102	4935
RPS15	-7592	4426
EIF3M	-10593	2961
RPS10	-8578	3553
RPS3	-9260	3262
RPS20	-9206	2822

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF1AX	-4224	-3200
EIF2S1	1134	-7680
EIF2S2	1009	-8896
EIF2S3	-8440	-5447
EIF3A	-5698	1014
EIF3B	-7939	9565
EIF3C	-7727	4981
EIF3D	-8646	2351
EIF3E	-9990	1992
EIF3F	-8955	8003
EIF3G	-8914	7623
EIF3H	-8454	1953
EIF3I	-5939	-1862
EIF3J	-6194	-9052
EIF3K	-8872	3993
EIF3L	-10568	7038
EIF3M	-10593	2961
FAU	-7843	4785
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811

---

---

Scavenging by Class F Receptors

Scavenging by Class F Receptors

metric	value
setSize	5
pMANOVA	0.105
p.adjustMANOVA	0.213
s.dist	0.674
s.crp_pod1_adj	0.487
s.dex_pod1_adj	-0.466
p.crp_pod1_adj	0.0594
p.dex_pod1_adj	0.0711

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
CALR	10166	-10611
HYOU1	9974	-10397
HSPH1	8395	-7985
HSP90AA1	6767	-7943

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CALR	10166	-10611
HSP90AA1	6767	-7943
HSPH1	8395	-7985
HYOU1	9974	-10397
SCARF1	-10882	10164

---

---

Ethanol oxidation

Ethanol oxidation

metric	value
setSize	6
pMANOVA	0.052
p.adjustMANOVA	0.127
s.dist	0.672
s.crp_pod1_adj	-0.568
s.dex_pod1_adj	0.358
p.crp_pod1_adj	0.016
p.dex_pod1_adj	0.129

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
ALDH1A1	-10915	10191
ACSS1	-10347	9671
ALDH2	-7135	10010
ALDH1B1	-7209	440

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
ACSS1	-10347	9671
ACSS2	7954	-5299
ADH5	-10292	-4597
ALDH1A1	-10915	10191
ALDH1B1	-7209	440
ALDH2	-7135	10010

---

---

MET activates PI3K/AKT signaling

MET activates PI3K/AKT signaling

metric	value
setSize	5
pMANOVA	0.11
p.adjustMANOVA	0.217
s.dist	0.668
s.crp_pod1_adj	0.486
s.dex_pod1_adj	-0.458
p.crp_pod1_adj	0.06
p.dex_pod1_adj	0.0761

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
HGF	8594	-10491
PIK3CA	5469	-8890
PIK3R1	5071	-5606
GRB2	6102	-4488

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
GAB1	-877	3131
GRB2	6102	-4488
HGF	8594	-10491
PIK3CA	5469	-8890
PIK3R1	5071	-5606

---

---

RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

metric	value
setSize	7
pMANOVA	0.0457
p.adjustMANOVA	0.116
s.dist	0.667
s.crp_pod1_adj	0.459
s.dex_pod1_adj	-0.483
p.crp_pod1_adj	0.0353
p.dex_pod1_adj	0.0268

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RUNX1	10315	-10752
SOCS3	10320	-10421
CTSL	10248	-10029
CBFB	4970	-9467
CTSV	8836	-433

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
CBFB	4970	-9467
CTSK	-8365	7562
CTSL	10248	-10029
CTSV	8836	-433
RUNX1	10315	-10752
SOCS3	10320	-10421
SOCS4	-4194	-5224

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	111
pMANOVA	1.45e-30
p.adjustMANOVA	2.53e-28
s.dist	0.666
s.crp_pod1_adj	-0.63
s.dex_pod1_adj	0.214
p.crp_pod1_adj	1.54e-30
p.dex_pod1_adj	9.51e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
RPS4Y1	-9472	9683
EIF3B	-7939	9565
EIF3L	-10568	7038
RPL29	-9905	7249
EIF3F	-8955	8003
EIF3G	-8914	7623
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EIF4A1	-6442	8203
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
RPL10	-9193	5255
RPS16	-7012	6858
RPL18A	-8223	5644
RPL15	-8846	5049

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF1AX	-4224	-3200
EIF2S1	1134	-7680
EIF2S2	1009	-8896
EIF2S3	-8440	-5447
EIF3A	-5698	1014
EIF3B	-7939	9565
EIF3C	-7727	4981
EIF3D	-8646	2351
EIF3E	-9990	1992
EIF3F	-8955	8003
EIF3G	-8914	7623
EIF3H	-8454	1953
EIF3I	-5939	-1862
EIF3J	-6194	-9052
EIF3K	-8872	3993
EIF3L	-10568	7038
EIF3M	-10593	2961
EIF4A1	-6442	8203
EIF4A2	-6158	-560
EIF4B	-10332	2485
EIF4E	7774	-9579
EIF4G1	9201	2288
EIF4H	-1997	-515
EIF5	-1825	1520
EIF5B	-1181	-7285
FAU	-7843	4785
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

metric	value
setSize	118
pMANOVA	7.57e-32
p.adjustMANOVA	1.82e-29
s.dist	0.665
s.crp_pod1_adj	-0.626
s.dex_pod1_adj	0.222
p.crp_pod1_adj	5.64e-32
p.dex_pod1_adj	2.99e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
EIF4EBP1	-9923	9475
RPS4Y1	-9472	9683
EIF2B1	-10174	8236
EIF3B	-7939	9565
EIF3L	-10568	7038
RPL29	-9905	7249
EIF3F	-8955	8003
EIF3G	-8914	7623
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EIF4A1	-6442	8203
EIF2B4	-6196	8120
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
EIF2B5	-5246	9414

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF1AX	-4224	-3200
EIF2B1	-10174	8236
EIF2B2	2557	-4443
EIF2B3	-4327	-5610
EIF2B4	-6196	8120
EIF2B5	-5246	9414
EIF2S1	1134	-7680
EIF2S2	1009	-8896
EIF2S3	-8440	-5447
EIF3A	-5698	1014
EIF3B	-7939	9565
EIF3C	-7727	4981
EIF3D	-8646	2351
EIF3E	-9990	1992
EIF3F	-8955	8003
EIF3G	-8914	7623
EIF3H	-8454	1953
EIF3I	-5939	-1862
EIF3J	-6194	-9052
EIF3K	-8872	3993
EIF3L	-10568	7038
EIF3M	-10593	2961
EIF4A1	-6442	8203
EIF4A2	-6158	-560
EIF4B	-10332	2485
EIF4E	7774	-9579
EIF4EBP1	-9923	9475
EIF4G1	9201	2288
EIF4H	-1997	-515
EIF5	-1825	1520
EIF5B	-1181	-7285
FAU	-7843	4785
PABPC1	-10239	-2209
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

metric	value
setSize	118
pMANOVA	7.57e-32
p.adjustMANOVA	1.82e-29
s.dist	0.665
s.crp_pod1_adj	-0.626
s.dex_pod1_adj	0.222
p.crp_pod1_adj	5.64e-32
p.dex_pod1_adj	2.99e-05

Top 20 genes

Gene	crp_pod1_adj	dex_pod1_adj
EIF4EBP1	-9923	9475
RPS4Y1	-9472	9683
EIF2B1	-10174	8236
EIF3B	-7939	9565
EIF3L	-10568	7038
RPL29	-9905	7249
EIF3F	-8955	8003
EIF3G	-8914	7623
RPL39L	-9834	6787
RPL8	-8894	7397
RPS4X	-10154	6346
RPS13	-10047	5791
RPS14	-8302	6979
RPS11	-8836	6484
EIF4A1	-6442	8203
EIF2B4	-6196	8120
RPS2	-7645	6571
RPL34	-9464	5305
RPL18	-9366	5294
EIF2B5	-5246	9414

Click HERE to show all gene set members

All member genes

	crp_pod1_adj	dex_pod1_adj
EIF1AX	-4224	-3200
EIF2B1	-10174	8236
EIF2B2	2557	-4443
EIF2B3	-4327	-5610
EIF2B4	-6196	8120
EIF2B5	-5246	9414
EIF2S1	1134	-7680
EIF2S2	1009	-8896
EIF2S3	-8440	-5447
EIF3A	-5698	1014
EIF3B	-7939	9565
EIF3C	-7727	4981
EIF3D	-8646	2351
EIF3E	-9990	1992
EIF3F	-8955	8003
EIF3G	-8914	7623
EIF3H	-8454	1953
EIF3I	-5939	-1862
EIF3J	-6194	-9052
EIF3K	-8872	3993
EIF3L	-10568	7038
EIF3M	-10593	2961
EIF4A1	-6442	8203
EIF4A2	-6158	-560
EIF4B	-10332	2485
EIF4E	7774	-9579
EIF4EBP1	-9923	9475
EIF4G1	9201	2288
EIF4H	-1997	-515
EIF5	-1825	1520
EIF5B	-1181	-7285
FAU	-7843	4785
PABPC1	-10239	-2209
RPL10	-9193	5255
RPL10A	-8093	1309
RPL11	-8932	2550
RPL12	-8971	-2346
RPL13	-5801	-2495
RPL13A	-8632	4080
RPL14	-8257	-514
RPL15	-8846	5049
RPL17	-8359	-54
RPL18	-9366	5294
RPL18A	-8223	5644
RPL19	-8300	2525
RPL21	-8575	1148
RPL22	-9058	-52
RPL22L1	-9402	-587
RPL23	-7851	1590
RPL23A	-8695	3432
RPL24	-8009	-788
RPL26	-9580	4662
RPL26L1	1524	-3887
RPL27	-7255	1577
RPL27A	-7212	-1505
RPL28	-6550	2890
RPL29	-9905	7249
RPL3	-8725	4145
RPL30	-8665	4966
RPL31	-8380	3558
RPL32	-7813	3303
RPL34	-9464	5305
RPL35	-5324	2761
RPL35A	-9421	2174
RPL36	-5842	3277
RPL36A	-8635	3427
RPL36AL	321	-3618
RPL37	-6639	4075
RPL37A	-6495	2070
RPL38	-7530	5206
RPL39	-8078	5174
RPL39L	-9834	6787
RPL3L	-8254	-7409
RPL4	-9637	2954
RPL41	-6731	224
RPL5	-9353	1360
RPL6	-8995	1107
RPL7	-9553	2260
RPL7A	-9040	2734
RPL8	-8894	7397
RPL9	460	-1781
RPLP0	-5840	3027
RPLP1	-4245	548
RPLP2	-6981	3227
RPS10	-8578	3553
RPS11	-8836	6484
RPS12	-7527	559
RPS13	-10047	5791
RPS14	-8302	6979
RPS15	-7592	4426
RPS15A	-7215	1174
RPS16	-7012	6858
RPS17	-4935	159
RPS18	-6316	1926
RPS19	-6357	1559
RPS2	-7645	6571
RPS20	-9206	2822
RPS21	-6334	2297
RPS23	-7122	2907
RPS24	-8168	986
RPS25	-8214	-287
RPS26	6287	-3301
RPS27	-6034	1766
RPS27A	-8697	1977
RPS27L	-7877	-4922
RPS28	-7102	4935
RPS29	-2897	974
RPS3	-9260	3262
RPS3A	-9507	2361
RPS4X	-10154	6346
RPS4Y1	-9472	9683
RPS5	-5787	4159
RPS6	-7638	-2674
RPS7	-9302	296
RPS8	-7537	946
RPS9	-4833	-4180
RPSA	-6608	-811
UBA52	-8729	4310

---

---

Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}

## Network charts only generated in one-dimensional analysis.

Session information

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.5.2 (2025-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8          LC_NUMERIC=C                 
##  [3] LC_TIME=en_US.UTF-8           LC_COLLATE=en_US.UTF-8       
##  [5] LC_MONETARY=en_US.UTF-8       LC_MESSAGES=en_US.UTF-8      
##  [7] LC_PAPER=en_US.UTF-8          LC_NAME=en_US.UTF-8          
##  [9] LC_ADDRESS=en_US.UTF-8        LC_TELEPHONE=en_US.UTF-8     
## [11] LC_MEASUREMENT=en_US.UTF-8    LC_IDENTIFICATION=en_US.UTF-8
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] gtools_3.9.5                RhpcBLASctl_0.23-42        
##  [3] xlsx_0.6.5                  DT_0.34.0                  
##  [5] eulerr_7.1.0                ggplot2_4.0.3              
##  [7] kableExtra_1.4.0            MASS_7.3-65                
##  [9] mitch_1.22.1                DESeq2_1.50.2              
## [11] SummarizedExperiment_1.40.0 Biobase_2.70.0             
## [13] MatrixGenerics_1.22.0       matrixStats_1.5.0          
## [15] GenomicRanges_1.62.1        Seqinfo_1.0.0              
## [17] IRanges_2.44.0              S4Vectors_0.48.1           
## [19] BiocGenerics_0.56.0         generics_0.1.4             
## [21] dplyr_1.2.1                 WGCNA_1.74                 
## [23] fastcluster_1.3.0           dynamicTreeCut_1.63-1      
## [25] reshape2_1.4.5              gplots_3.3.0               
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3    rstudioapi_0.17.1     jsonlite_2.0.0       
##   [4] magrittr_2.0.4        farver_2.1.2          rmarkdown_2.30       
##   [7] vctrs_0.7.3           base64enc_0.1-3       htmltools_0.5.8.1    
##  [10] S4Arrays_1.10.1       progress_1.2.3        SparseArray_1.10.10  
##  [13] Formula_1.2-5         sass_0.4.10           KernSmooth_2.23-26   
##  [16] bslib_0.9.0           htmlwidgets_1.6.4     plyr_1.8.9           
##  [19] echarts4r_0.5.0       impute_1.84.0         cachem_1.1.0         
##  [22] mime_0.13             lifecycle_1.0.5       iterators_1.0.14     
##  [25] pkgconfig_2.0.3       Matrix_1.7-4          R6_2.6.1             
##  [28] fastmap_1.2.0         shiny_1.11.1          digest_0.6.39        
##  [31] colorspace_2.1-2      GGally_2.4.0          textshaping_1.0.4    
##  [34] Hmisc_5.2-5           labeling_0.4.3        polyclip_1.10-7      
##  [37] abind_1.4-8           compiler_4.5.2        withr_3.0.2          
##  [40] doParallel_1.0.17     htmlTable_2.5.0       S7_0.2.2             
##  [43] backports_1.5.1       BiocParallel_1.44.0   ggstats_0.13.0       
##  [46] DelayedArray_0.36.1   caTools_1.18.3        tools_4.5.2          
##  [49] foreign_0.8-90        otel_0.2.0            beeswarm_0.4.0       
##  [52] httpuv_1.6.16         nnet_7.3-20           glue_1.8.0           
##  [55] promises_1.5.0        grid_4.5.2            polylabelr_1.0.0     
##  [58] checkmate_2.3.4       cluster_2.1.8.1       gtable_0.3.6         
##  [61] preprocessCore_1.72.0 tidyr_1.3.2           hms_1.1.4            
##  [64] data.table_1.18.4     xml2_1.5.1            XVector_0.50.0       
##  [67] foreach_1.5.2         pillar_1.11.1         stringr_1.6.0        
##  [70] later_1.4.4           rJava_1.0-18          splines_4.5.2        
##  [73] lattice_0.22-7        survival_3.8-3        tidyselect_1.2.1     
##  [76] locfit_1.5-9.12       knitr_1.50            gridExtra_2.3        
##  [79] svglite_2.2.2         xfun_0.54             stringi_1.8.7        
##  [82] statnet.common_4.13.0 yaml_2.3.11           evaluate_1.0.5       
##  [85] codetools_0.2-20      xlsxjars_0.9.0        tibble_3.3.0         
##  [88] cli_3.6.5             rpart_4.1.24          xtable_1.8-4         
##  [91] systemfonts_1.3.1     jquerylib_0.1.4       network_1.20.0       
##  [94] Rcpp_1.1.1-1.1        coda_0.19-4.1         parallel_4.5.2       
##  [97] prettyunits_1.2.0     bitops_1.0-9          viridisLite_0.4.3    
## [100] scales_1.4.0          purrr_1.2.0           crayon_1.5.3         
## [103] rlang_1.2.0

END of report