Activation of NOXA and translocation to mitochondria
E2F-enabled inhibition of pre-replication complex formation
Activation of NIMA Kinases NEK9, NEK6, NEK7
Assembly of active LPL and LIPC lipase complexes
Loss of Function of KMT2D in Kabuki Syndrome
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
CDC6 association with the ORC:origin complex
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Erythropoietin activates Phospholipase C gamma (PLCG)
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Loss of MECP2 binding ability to the NCoR/SMRT complex
RUNX2 regulates genes involved in cell migration
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Initiation of Nuclear Envelope (NE) Reformation
Assembly of the ORC complex at the origin of replication
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Association of TriC/CCT with target proteins during biosynthesis
Formation of the polybromo-BAF (pBAF) complex
Formation of tubulin folding intermediates by CCT/TriC
Respiratory syncytial virus (RSV) genome replication, transcription and translation
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Activation of BAD and translocation to mitochondria
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
ChREBP activates metabolic gene expression
Defective HLCS causes multiple carboxylase deficiency
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Termination of translesion DNA synthesis
Establishment of Sister Chromatid Cohesion
Interconversion of nucleotide di- and triphosphates
CaMK IV-mediated phosphorylation of CREB
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Activation of PUMA and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Regulation of CDH1 mRNA translation by microRNAs
Small interfering RNA (siRNA) biogenesis
YAP1- and WWTR1 (TAZ)-stimulated gene expression
The role of GTSE1 in G2/M progression after G2 checkpoint
B-WICH complex positively regulates rRNA expression
Formation of the non-canonical BAF (ncBAF) complex
Golgi Cisternae Pericentriolar Stack Reorganization
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
TP53 Regulates Transcription of Cell Cycle Genes
Positive epigenetic regulation of rRNA expression
APC/C:Cdc20 mediated degradation of Cyclin B
Carboxyterminal post-translational modifications of tubulin
Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding
Formation of the beta-catenin:TCF transactivating complex
Antiviral mechanism by IFN-stimulated genes
Regulation of mRNA stability by proteins that bind AU-rich elements
Regulation of TP53 Activity through Acetylation
ATF4 activates genes in response to endoplasmic reticulum  stress
RNA Pol II CTD phosphorylation and interaction with CE
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Transcriptional regulation of brown and beige adipocyte differentiation
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of localization of FOXO transcription factors
APOBEC3G mediated resistance to HIV-1 infection
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Binding of TCF/LEF:CTNNB1 to target gene promoters
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
PDH complex synthesizes acetyl-CoA from PYR
RUNX1 regulates estrogen receptor mediated transcription
SARS-CoV-2 activates/modulates innate and adaptive immune responses
RNA Polymerase III Transcription Initiation From Type 2 Promoter
Formation of WDR5-containing histone-modifying complexes
Regulation of ornithine decarboxylase (ODC)
Formation of the embryonic stem cell BAF (esBAF) complex
Regulation of RUNX1 Expression and Activity
Cyclin A:Cdk2-associated events at S phase entry
E3 ubiquitin ligases ubiquitinate target proteins
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Telomere C-strand (Lagging Strand) Synthesis
Loss of function of MECP2 in Rett syndrome
Negative regulation of NMDA receptor-mediated neuronal transmission
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Damage/Telomere Stress Induced Senescence
Aberrant regulation of mitotic cell cycle due to RB1 defects
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Prefoldin mediated transfer of substrate  to CCT/TriC
RNA Polymerase III Transcription Initiation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
AUF1 (hnRNP D0) binds and destabilizes mRNA
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Retrograde transport at the Trans-Golgi-Network
SCF-beta-TrCP mediated degradation of Emi1
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
STING mediated induction of host immune responses
Z-decay: degradation of maternal mRNAs by zygotically expressed factors
NFE2L2 regulating MDR associated enzymes
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
RAS signaling downstream of NF1 loss-of-function variants
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Regulation of gene expression in beta cells
Sema4D mediated inhibition of cell attachment and migration
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Loss of proteins required for interphase microtubule organization from the centrosome
Regulation of RUNX2 expression and activity
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
M-decay: degradation of maternal mRNAs by maternally stored factors
Regulation of TP53 Expression and Degradation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Downregulation of TGF-beta receptor signaling
Polymerase switching on the C-strand of the telomere
Recruitment of NuMA to mitotic centrosomes
RNA Polymerase III Abortive And Retractive Initiation
FASTK family proteins regulate processing and stability of mitochondrial RNAs
Processive synthesis on the C-strand of the telomere
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Negative Regulation of CDH1 Gene Transcription
Recruitment of mitotic centrosome proteins and complexes
Autodegradation of the E3 ubiquitin ligase COP1
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Metabolism of nitric oxide: NOS3 activation and regulation
Regulation of TP53 Activity through Association with Co-factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Regulation of PLK1 Activity at G2/M Transition
Transport of inorganic cations/anions and amino acids/oligopeptides
p53-Dependent G1/S DNA damage checkpoint
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Regulation of MECP2 expression and activity
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Factors involved in megakaryocyte development and platelet production
Regulation of PTEN stability and activity
Nuclear events stimulated by ALK signaling in cancer
Defective B3GALT6 causes EDSP2 and SEMDJL1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Post-transcriptional silencing by small RNAs
Reversal of alkylation damage by DNA dioxygenases
Unblocking of NMDA receptors, glutamate binding and activation
TCF dependent signaling in response to WNT
Cargo trafficking to the periciliary membrane
Plasma lipoprotein assembly, remodeling, and clearance
Signaling by ALK fusions and activated point mutants
Anchoring of the basal body to the plasma membrane
Transcriptional activation of mitochondrial biogenesis
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
p53-Independent G1/S DNA Damage Checkpoint
Defective Intrinsic Pathway for Apoptosis
Regulation of activated PAK-2p34 by proteasome mediated degradation
SARS-CoV-1 activates/modulates innate immune responses
Mitochondrial unfolded protein response (UPRmt)
Processive synthesis on the lagging strand
Regulation of RUNX3 expression and activity
Cross-presentation of soluble exogenous antigens (endosomes)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Ubiquitin-dependent degradation of Cyclin D
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Binding and Uptake of Ligands by Scavenger Receptors
Diseases associated with glycosylation precursor biosynthesis
Formation of the canonical BAF (cBAF) complex
Miscellaneous transport and binding events
N-glycan antennae elongation in the medial/trans-Golgi
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Regulation of MITF-M-dependent genes involved in apoptosis
Synthesis of PIPs at the early endosome membrane
Activated NTRK2 signals through FRS2 and FRS3
Cellular response to mitochondrial stress
Gain-of-function MRAS complexes activate RAF signaling
Glyoxylate metabolism and glycine degradation
RHO GTPases Activate Rhotekin and Rhophilins
Regulation of CDH11 mRNA translation by microRNAs
SHOC2 M1731 mutant abolishes MRAS complex function
Zinc influx into cells by the SLC39 gene family
Epigenetic regulation by WDR5-containing histone modifying complexes
Dectin-1 mediated noncanonical NF-kB signaling
Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Activation of gene expression by SREBF (SREBP)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Constitutive Signaling by AKT1 E17K in Cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of beta-catenin by the destruction complex
Transcriptional and post-translational regulation of MITF-M expression and activity
Defects in vitamin and cofactor metabolism
G beta:gamma signalling through PI3Kgamma
Removal of the Flap Intermediate from the C-strand
Signaling by cytosolic FGFR1 fusion mutants
Regulation of endogenous retroelements by KRAB-ZFP proteins
Diseases of signal transduction by growth factor receptors and second messengers
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Collagen biosynthesis and modifying enzymes
Modulation of host responses by IFN-stimulated genes
Respiratory syncytial virus (RSV) attachment and entry
AKT phosphorylates targets in the nucleus
Activation of the AP-1 family of transcription factors
Advanced glycosylation endproduct receptor signaling
GABA synthesis, release, reuptake and degradation
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Positive Regulation of CDH1 Gene Transcription
STAT5 activation downstream of FLT3 ITD mutants
The canonical retinoid cycle in rods (twilight vision)
Transport of connexons to the plasma membrane
mitochondrial fatty acid beta-oxidation of saturated fatty acids
Downstream signaling events of B Cell Receptor (BCR)
GLI3 is processed to GLI3R by the proteasome
Metabolism of carbohydrates and carbohydrate derivatives
Regulation of CDH1 Expression and Function
Regulation of Expression and Function of Type I Classical Cadherins
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Formation of the dystrophin-glycoprotein complex (DGC)
Regulation of TP53 Activity through Methylation
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Intracellular signaling by second messengers
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Regulation of Homotypic Cell-Cell Adhesion
TGF-beta receptor signaling activates SMADs
RNA Polymerase III Transcription Termination
ATF6 (ATF6-alpha) activates chaperone genes
CLEC7A (Dectin-1) induces NFAT activation
CREB1 phosphorylation through the activation of Adenylate Cyclase
Degradation of cysteine and homocysteine
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
Ras activation upon Ca2+ influx through NMDA receptor
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Signal regulatory protein family interactions
Synthesis of substrates in N-glycan biosythesis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Transport of bile salts and organic acids, metal ions and amine compounds
Metabolism of water-soluble vitamins and cofactors
TP53 Regulates Transcription of Cell Death Genes
Assembly and cell surface presentation of NMDA receptors
Glucagon signaling in metabolic regulation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Abortive elongation of HIV-1 transcript in the absence of Tat
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Constitutive Signaling by Overexpressed ERBB2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
MECP2 regulates neuronal receptors and channels
Prostacyclin signalling through prostacyclin receptor
Recognition and association of DNA glycosylase with site containing an affected purine
Synthesis of PIPs at the late endosome membrane
Cytosolic sensors of pathogen-associated DNA
Antigen processing: Ubiquitination & Proteasome degradation
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of T cell activation by CD28 family
Activation of NMDA receptors and postsynaptic events
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Diseases associated with the TLR signaling cascade
Activation of G protein gated Potassium channels
Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Class I MHC mediated antigen processing & presentation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Cellular responses to mechanical stimuli
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Assembly of collagen fibrils and other multimeric structures
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Aerobic respiration and respiratory electron transport
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Vasopressin regulates renal water homeostasis via Aquaporins
ADP signalling through P2Y purinoceptor 12
Formation of Fibrin Clot (Clotting Cascade)
G beta:gamma signalling through PLC beta
Generation of second messenger molecules
NPAS4 regulates expression of target genes
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Presynaptic function of Kainate receptors
Regulation of pyruvate dehydrogenase (PDH) complex
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Regulation of actin dynamics for phagocytic cup formation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of expression of SLITs and ROBOs
Diseases associated with glycosaminoglycan metabolism
Energy dependent regulation of mTOR by LKB1-AMPK
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
RNA polymerase II transcribes snRNA genes
Response of endothelial cells to shear stress
Respiratory Syncytial Virus Infection Pathway
Detoxification of Reactive Oxygen Species
AKT phosphorylates targets in the cytosol
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Defective B4GALT7 causes EDS, progeroid type
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Response of EIF2AK1 (HRI) to heme deficiency
Truncations of AMER1 destabilize the destruction complex
Metabolism of amino acids and derivatives
Regulation of lipid metabolism by PPARalpha
NOTCH1 Intracellular Domain Regulates Transcription
ADORA2B mediated anti-inflammatory cytokines production
Signaling by CSF1 (M-CSF) in myeloid cells
Cell death signalling via NRAGE, NRIF and NADE
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
Molecules associated with elastic fibres
Signaling by CTNNB1 phospho-site mutants
Synthesis of very long-chain fatty acyl-CoAs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of MITF-M-dependent genes involved in pigmentation
ADP signalling through P2Y purinoceptor 1
Activation of kainate receptors upon glutamate binding
O-glycosylation of TSR domain-containing proteins
Thromboxane signalling through TP receptor
Neurotransmitter receptors and postsynaptic signal transmission
SARS-CoV-2 modulates host translation machinery
Deactivation of the beta-catenin transactivating complex
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Signaling by Ligand-Responsive EGFR Variants in Cancer
Constitutive Signaling by Aberrant PI3K in Cancer
Negative regulators of DDX58/IFIH1 signaling
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling by moderate kinase activity BRAF mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Anti-inflammatory response favouring Leishmania parasite infection
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Transport to the Golgi and subsequent modification
Antigen processing: Ub, ATP-independent proteasomal degradation
Maturation of TCA enzymes and regulation of TCA cycle
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Regulation of CDH11 Expression and Function
Sealing of the nuclear envelope (NE) by ESCRT-III
Ribosomal scanning and start codon recognition
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Diseases associated with N-glycosylation of proteins
Inhibition of DNA recombination at telomere
Regulation of Expression and Function of Type II Classical Cadherins
Post-translational modification: synthesis of GPI-anchored proteins
Signaling by Non-Receptor Tyrosine Kinases
Phase I - Functionalization of compounds
JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1
Negative regulation of the PI3K/AKT network
Synthesis of PIPs at the plasma membrane
Platelet activation, signaling and aggregation
NOTCH3 Activation and Transmission of Signal to the Nucleus
Thrombin signalling through proteinase activated receptors (PARs)
MyD88 cascade initiated on plasma membrane
Purinergic signaling in leishmaniasis infection
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
Transcriptional regulation of white adipocyte differentiation
Transport of vitamins, nucleosides, and related molecules
Cargo recognition for clathrin-mediated endocytosis
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Cell surface interactions at the vascular wall
Nuclear Events (kinase and transcription factor activation)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
GTP hydrolysis and joining of the 60S ribosomal subunit
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Diseases associated with O-glycosylation of proteins
MAPK targets/ Nuclear events mediated by MAP kinases
Sensory processing of sound by inner hair cells of the cochlea
SARS-CoV-1 modulates host translation machinery
Interleukin-3, Interleukin-5 and GM-CSF signaling
Response to elevated platelet cytosolic Ca2+
Formation of the ternary complex, and subsequently, the 43S complex
L13a-mediated translational silencing of Ceruloplasmin expression
Response of EIF2AK4 (GCN2) to amino acid deficiency
AMPK inhibits chREBP transcriptional activation activity
Activated NOTCH1 Transmits Signal to the Nucleus
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of caspases through apoptosome-mediated cleavage
Activation of the TFAP2 (AP-2) family of transcription factors
Alpha-protein kinase 1 signaling pathway
Attachment of bacteria to epithelial cells
Axonal growth inhibition (RHOA activation)
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta-oxidation of very long chain fatty acids
Biosynthesis of specialized proresolving mediators (SPMs)
CD163 mediating an anti-inflammatory response
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Caspase-mediated cleavage of cytoskeletal proteins
Chromatin modifications during the maternal to zygotic transition (MZT)
Class I peroxisomal membrane protein import
Cobalamin (Cbl, vitamin B12) transport and metabolism
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Cross-presentation of particulate exogenous antigens (phagosomes)
Cytochrome P450 - arranged by substrate type
Cytosolic sulfonation of small molecules
Defective CHST14 causes EDS, musculocontractural type
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
Developmental Cell Lineages of the Exocrine Pancreas
Developmental Lineage of Pancreatic Ductal Cells
Diseases of branched-chain amino acid catabolism
Displacement of DNA glycosylase by APEX1
Endosomal Sorting Complex Required For Transport (ESCRT)
Epithelial-Mesenchymal Transition (EMT) during gastrulation
Erythrocytes take up carbon dioxide and release oxygen
Evasion by RSV of host interferon responses
Expression and translocation of olfactory receptors
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell death genes
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Formation of a pool of free 40S subunits
Formation of the active cofactor, UDP-glucuronate
Free fatty acids regulate insulin secretion
GRB2:SOS provides linkage to MAPK signaling for Integrins
Gastrin-CREB signalling pathway via PKC and MAPK
IKK complex recruitment mediated by RIP1
IL-6-type cytokine receptor ligand interactions
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Inactivation, recovery and regulation of the phototransduction cascade
Incretin synthesis, secretion, and inactivation
InlA-mediated entry of Listeria monocytogenes into host cells
InlB-mediated entry of Listeria monocytogenes into host cell
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Intrinsic Pathway of Fibrin Clot Formation
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Listeria monocytogenes entry into host cells
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
MECP2 regulates transcription of neuronal ligands
Membrane binding and targetting of GAG proteins
Metabolic disorders of biological oxidation enzymes
Metabolism of Angiotensinogen to Angiotensins
Metabolism of ingested SeMet, Sec, MeSec into H2Se
N-glycan trimming and elongation in the cis-Golgi
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating ER-stress associated genes
NFE2L2 regulating inflammation associated genes
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 intracellular domain regulates transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Activation and Transmission of Signal to the Nucleus
NOTCH4 Intracellular Domain Regulates Transcription
NRIF signals cell death from the nucleus
Nef mediated downregulation of MHC class I complex cell surface expression
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Negative feedback regulation of MAPK pathway
Nitric oxide stimulates guanylate cyclase
POLB-Dependent Long Patch Base Excision Repair
PP2A-mediated dephosphorylation of key metabolic factors
PTK6 Regulates Proteins Involved in RNA Processing
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Phosphate bond hydrolysis by NTPDase proteins
Phosphate bond hydrolysis by NUDT proteins
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Phosphorylation of CD3 and TCR zeta chains
Pre-NOTCH Processing in the Endoplasmic Reticulum
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 regulates BCL2L11 (BIM) transcription
Reactions specific to the complex N-glycan synthesis pathway
Regulation of FOXO transcriptional activity by acetylation
Regulation of HMOX1 expression and activity
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Regulation of gene expression by Hypoxia-inducible Factor
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Regulation of innate immune responses to cytosolic DNA
Release of apoptotic factors from the mitochondria
Role of LAT2/NTAL/LAB on calcium mobilization
SIRT1 negatively regulates rRNA expression
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SRP-dependent cotranslational protein targeting to membrane
STAT3 nuclear events downstream of ALK signaling
Sema4D induced cell migration and growth-cone collapse
Sensory perception of sweet, bitter, and umami (glutamate) taste
Sensory processing of sound by outer hair cells of the cochlea
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by PDGFRA extracellular domain mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by high-kinase activity BRAF mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Synthesis And Processing Of GAG, GAGPOL Polyproteins
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of pyrophosphates in the cytosol
Synthesis of wybutosine at G37 of tRNA(Phe)
Synthesis, secretion, and deacylation of Ghrelin
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
TICAM1, RIP1-mediated IKK complex recruitment
TICAM1,TRAF6-dependent induction of TAK1 complex
TLR3-mediated TICAM1-dependent programmed cell death
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6-mediated induction of TAK1 complex within TLR4 complex
The role of Nef in HIV-1 replication and disease pathogenesis
Trafficking and processing of endosomal TLR
Trafficking of GluR2-containing AMPA receptors
Transcriptional regulation of pluripotent stem cells
Translation of Replicase and Assembly of the Replication Transcription Complex_9679504
Translation of Replicase and Assembly of the Replication Transcription Complex_9694676
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
ZBP1(DAI) mediated induction of type I IFNs
activated TAK1 mediates p38 MAPK activation
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
p130Cas linkage to MAPK signaling for integrins
p75NTR negatively regulates cell cycle via SC1