Mitch Report

date generated: 2022-08-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                 x
## A4GALT  0.5563104
## AAAS   -9.3505565
## AACS   17.4368054
## AAGAB   0.6211840
## AAK1   10.8699941
## AAMDC  -5.4631631

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2551
num_genes_in_profile	12290
duplicated_genes_present	0
num_profile_genes_in_sets	7289
num_profile_genes_not_in_sets	5001

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2551
num_genesets_excluded	1183
num_genesets_included	1368

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
tRNA processing in the mitochondrion	18	2.56e-07	-0.701	8.76e-06
Cholesterol biosynthesis	26	1.02e-09	0.692	4.97e-08
rRNA processing in the mitochondrion	21	8.74e-07	-0.620	2.54e-05
MET activates PTK2 signaling	12	6.11e-04	0.571	8.12e-03
ALK mutants bind TKIs	10	2.10e-03	0.562	2.07e-02
Laminin interactions	18	3.71e-05	0.562	7.15e-04
Apoptosis induced DNA fragmentation	10	5.04e-03	0.512	3.56e-02
Membrane binding and targetting of GAG proteins	14	1.20e-03	-0.500	1.43e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.20e-03	-0.500	1.43e-02
Formation of a pool of free 40S subunits	79	4.97e-14	-0.490	1.72e-11
Peptide chain elongation	67	4.04e-12	-0.490	4.60e-10
Syndecan interactions	19	2.68e-04	0.483	3.95e-03
Eukaryotic Translation Termination	71	3.87e-12	-0.477	4.60e-10
Formation of the ternary complex, and subsequently, the 43S complex	47	1.87e-08	-0.474	7.52e-07
Viral mRNA Translation	67	1.99e-11	-0.474	1.30e-09
Telomere C-strand synthesis initiation	13	3.38e-03	-0.470	2.82e-02
Mitochondrial translation initiation	88	2.75e-14	-0.470	1.72e-11
Mitochondrial translation termination	88	5.02e-14	-0.465	1.72e-11
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	3.89e-09	0.463	1.77e-07
Eukaryotic Translation Elongation	70	4.54e-11	-0.455	2.82e-09
Mitochondrial translation elongation	88	1.93e-13	-0.454	4.40e-11
Activation of gene expression by SREBF (SREBP)	41	5.14e-07	0.453	1.60e-05
Cytosolic tRNA aminoacylation	24	1.28e-04	0.452	2.06e-03
Selenocysteine synthesis	71	5.83e-11	-0.450	3.32e-09
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.18e-04	-0.445	3.32e-03
Mitochondrial translation	94	1.17e-13	-0.443	3.20e-11
MET promotes cell motility	22	3.22e-04	0.443	4.60e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	9.27e-11	-0.442	4.88e-09
Response of EIF2AK1 (HRI) to heme deficiency	15	3.12e-03	0.441	2.73e-02
Assembly Of The HIV Virion	16	2.28e-03	-0.441	2.21e-02
Complex I biogenesis	56	1.28e-08	-0.440	5.46e-07
SARS-CoV-2 modulates host translation machinery	45	3.63e-07	-0.438	1.21e-05
Regulation of innate immune responses to cytosolic DNA	13	6.51e-03	-0.436	4.20e-02
Kinesins	36	6.46e-06	0.435	1.64e-04
PKA activation	13	6.68e-03	0.435	4.21e-02
L13a-mediated translational silencing of Ceruloplasmin expression	88	6.67e-12	-0.424	5.98e-10
GTP hydrolysis and joining of the 60S ribosomal subunit	90	6.99e-12	-0.419	5.98e-10
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	92	5.54e-12	-0.416	5.41e-10
Nonsense-Mediated Decay (NMD)	92	5.54e-12	-0.416	5.41e-10
CLEC7A (Dectin-1) induces NFAT activation	10	2.32e-02	0.415	1.06e-01
Chondroitin sulfate biosynthesis	16	4.88e-03	0.407	3.51e-02
Non-integrin membrane-ECM interactions	34	4.44e-05	0.405	8.20e-04
HS-GAG degradation	18	3.04e-03	0.404	2.68e-02
Formation of ATP by chemiosmotic coupling	17	4.05e-03	-0.403	3.16e-02
Signaling by FLT3 fusion proteins	19	2.42e-03	0.402	2.29e-02
Nephrin family interactions	19	2.43e-03	0.402	2.29e-02
Collagen chain trimerization	26	4.18e-04	0.400	5.78e-03
Elastic fibre formation	31	1.19e-04	0.399	1.94e-03
Cap-dependent Translation Initiation	96	1.41e-11	-0.399	9.73e-10
Eukaryotic Translation Initiation	96	1.41e-11	-0.399	9.73e-10

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
tRNA processing in the mitochondrion	18	2.56e-07	-7.01e-01	8.76e-06
Cholesterol biosynthesis	26	1.02e-09	6.92e-01	4.97e-08
rRNA processing in the mitochondrion	21	8.74e-07	-6.20e-01	2.54e-05
MET activates PTK2 signaling	12	6.11e-04	5.71e-01	8.12e-03
ALK mutants bind TKIs	10	2.10e-03	5.62e-01	2.07e-02
Laminin interactions	18	3.71e-05	5.62e-01	7.15e-04
Apoptosis induced DNA fragmentation	10	5.04e-03	5.12e-01	3.56e-02
Membrane binding and targetting of GAG proteins	14	1.20e-03	-5.00e-01	1.43e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.20e-03	-5.00e-01	1.43e-02
Formation of a pool of free 40S subunits	79	4.97e-14	-4.90e-01	1.72e-11
Peptide chain elongation	67	4.04e-12	-4.90e-01	4.60e-10
Syndecan interactions	19	2.68e-04	4.83e-01	3.95e-03
Eukaryotic Translation Termination	71	3.87e-12	-4.77e-01	4.60e-10
Formation of the ternary complex, and subsequently, the 43S complex	47	1.87e-08	-4.74e-01	7.52e-07
Viral mRNA Translation	67	1.99e-11	-4.74e-01	1.30e-09
Telomere C-strand synthesis initiation	13	3.38e-03	-4.70e-01	2.82e-02
Mitochondrial translation initiation	88	2.75e-14	-4.70e-01	1.72e-11
Mitochondrial translation termination	88	5.02e-14	-4.65e-01	1.72e-11
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	3.89e-09	4.63e-01	1.77e-07
Eukaryotic Translation Elongation	70	4.54e-11	-4.55e-01	2.82e-09
Mitochondrial translation elongation	88	1.93e-13	-4.54e-01	4.40e-11
Activation of gene expression by SREBF (SREBP)	41	5.14e-07	4.53e-01	1.60e-05
Cytosolic tRNA aminoacylation	24	1.28e-04	4.52e-01	2.06e-03
Selenocysteine synthesis	71	5.83e-11	-4.50e-01	3.32e-09
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.18e-04	-4.45e-01	3.32e-03
Mitochondrial translation	94	1.17e-13	-4.43e-01	3.20e-11
MET promotes cell motility	22	3.22e-04	4.43e-01	4.60e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	9.27e-11	-4.42e-01	4.88e-09
Response of EIF2AK1 (HRI) to heme deficiency	15	3.12e-03	4.41e-01	2.73e-02
Assembly Of The HIV Virion	16	2.28e-03	-4.41e-01	2.21e-02
Complex I biogenesis	56	1.28e-08	-4.40e-01	5.46e-07
SARS-CoV-2 modulates host translation machinery	45	3.63e-07	-4.38e-01	1.21e-05
Regulation of innate immune responses to cytosolic DNA	13	6.51e-03	-4.36e-01	4.20e-02
Kinesins	36	6.46e-06	4.35e-01	1.64e-04
PKA activation	13	6.68e-03	4.35e-01	4.21e-02
L13a-mediated translational silencing of Ceruloplasmin expression	88	6.67e-12	-4.24e-01	5.98e-10
GTP hydrolysis and joining of the 60S ribosomal subunit	90	6.99e-12	-4.19e-01	5.98e-10
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	92	5.54e-12	-4.16e-01	5.41e-10
Nonsense-Mediated Decay (NMD)	92	5.54e-12	-4.16e-01	5.41e-10
CLEC7A (Dectin-1) induces NFAT activation	10	2.32e-02	4.15e-01	1.06e-01
Chondroitin sulfate biosynthesis	16	4.88e-03	4.07e-01	3.51e-02
Non-integrin membrane-ECM interactions	34	4.44e-05	4.05e-01	8.20e-04
HS-GAG degradation	18	3.04e-03	4.04e-01	2.68e-02
Formation of ATP by chemiosmotic coupling	17	4.05e-03	-4.03e-01	3.16e-02
Signaling by FLT3 fusion proteins	19	2.42e-03	4.02e-01	2.29e-02
Nephrin family interactions	19	2.43e-03	4.02e-01	2.29e-02
Collagen chain trimerization	26	4.18e-04	4.00e-01	5.78e-03
Elastic fibre formation	31	1.19e-04	3.99e-01	1.94e-03
Cap-dependent Translation Initiation	96	1.41e-11	-3.99e-01	9.73e-10
Eukaryotic Translation Initiation	96	1.41e-11	-3.99e-01	9.73e-10
Signaling by BMP	17	4.70e-03	3.96e-01	3.44e-02
Collagen formation	61	1.06e-07	3.94e-01	3.91e-06
Amino acid transport across the plasma membrane	23	1.28e-03	3.88e-01	1.48e-02
Synthesis of PIPs at the late endosome membrane	11	2.60e-02	3.88e-01	1.15e-01
Signaling by PDGFR in disease	17	5.72e-03	3.87e-01	3.82e-02
LDL clearance	17	5.73e-03	3.87e-01	3.82e-02
Translation initiation complex formation	53	1.18e-06	-3.86e-01	3.37e-05
Collagen biosynthesis and modifying enzymes	46	6.95e-06	3.83e-01	1.70e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	54	1.35e-06	-3.80e-01	3.77e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123	4.24e-13	-3.79e-01	8.29e-11
Tight junction interactions	12	2.39e-02	-3.77e-01	1.08e-01
RAF-independent MAPK1/3 activation	22	2.24e-03	3.77e-01	2.18e-02
HDMs demethylate histones	21	2.91e-03	3.75e-01	2.60e-02
Respiratory electron transport	102	6.23e-11	-3.75e-01	3.41e-09
Synthesis of PIPs at the early endosome membrane	15	1.20e-02	3.75e-01	6.60e-02
Mitotic Telophase/Cytokinesis	13	2.09e-02	3.70e-01	9.93e-02
Ribosomal scanning and start codon recognition	54	2.73e-06	-3.69e-01	7.32e-05
Chondroitin sulfate/dermatan sulfate metabolism	43	3.02e-05	3.68e-01	6.42e-04
RHO GTPases Activate NADPH Oxidases	13	2.26e-02	-3.65e-01	1.04e-01
Signaling by FGFR2 IIIa TM	19	5.93e-03	-3.65e-01	3.94e-02
Prolonged ERK activation events	13	2.31e-02	3.64e-01	1.06e-01
Sensory processing of sound by outer hair cells of the cochlea	27	1.08e-03	3.64e-01	1.34e-02
Interleukin-6 signaling	10	5.07e-02	3.57e-01	1.78e-01
Glucagon-type ligand receptors	12	3.27e-02	-3.56e-01	1.36e-01
Prostacyclin signalling through prostacyclin receptor	12	3.27e-02	-3.56e-01	1.36e-01
Formation of the Early Elongation Complex	33	4.12e-04	-3.55e-01	5.75e-03
Formation of the HIV-1 Early Elongation Complex	33	4.12e-04	-3.55e-01	5.75e-03
Molecules associated with elastic fibres	22	3.92e-03	3.55e-01	3.12e-02
Inhibition of DNA recombination at telomere	27	1.53e-03	-3.52e-01	1.69e-02
Establishment of Sister Chromatid Cohesion	11	4.35e-02	3.52e-01	1.61e-01
ECM proteoglycans	33	4.84e-04	3.51e-01	6.56e-03
Regulation of expression of SLITs and ROBOs	138	1.25e-12	-3.51e-01	1.90e-10
Assembly of collagen fibrils and other multimeric structures	39	1.62e-04	3.49e-01	2.58e-03
PKA-mediated phosphorylation of CREB	15	1.95e-02	3.48e-01	9.63e-02
PIWI-interacting RNA (piRNA) biogenesis	16	1.59e-02	-3.48e-01	8.27e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	3.68e-02	3.48e-01	1.47e-01
Defective EXT2 causes exostoses 2	12	3.68e-02	3.48e-01	1.47e-01
Cohesin Loading onto Chromatin	10	5.71e-02	3.48e-01	1.88e-01
PKA activation in glucagon signalling	12	3.73e-02	3.47e-01	1.48e-01
Pausing and recovery of Tat-mediated HIV elongation	30	1.08e-03	-3.45e-01	1.34e-02
Tat-mediated HIV elongation arrest and recovery	30	1.08e-03	-3.45e-01	1.34e-02
RNA Pol II CTD phosphorylation and interaction with CE	27	1.94e-03	-3.45e-01	1.97e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.94e-03	-3.45e-01	1.97e-02
RNA Polymerase III Transcription Termination	21	6.43e-03	-3.44e-01	4.19e-02
Budding and maturation of HIV virion	26	2.52e-03	-3.42e-01	2.33e-02
Mucopolysaccharidoses	11	4.96e-02	3.42e-01	1.76e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	19	1.01e-02	3.41e-01	5.72e-02
Defective B4GALT7 causes EDS, progeroid type	17	1.63e-02	3.37e-01	8.40e-02
Cristae formation	30	1.43e-03	-3.37e-01	1.60e-02
Receptor Mediated Mitophagy	10	6.77e-02	-3.34e-01	2.14e-01
Acyl chain remodelling of PE	13	3.74e-02	-3.33e-01	1.48e-01
Signaling by ALK fusions and activated point mutants	52	3.26e-05	3.33e-01	6.47e-04
Signaling by ALK in cancer	52	3.26e-05	3.33e-01	6.47e-04
FCGR3A-mediated IL10 synthesis	26	3.32e-03	3.33e-01	2.80e-02
Synthesis of PIPs at the Golgi membrane	15	2.57e-02	3.33e-01	1.15e-01
p38MAPK events	12	4.63e-02	-3.32e-01	1.68e-01
mRNA Capping	29	2.06e-03	-3.31e-01	2.04e-02
A tetrasaccharide linker sequence is required for GAG synthesis	22	7.49e-03	3.29e-01	4.57e-02
Repression of WNT target genes	14	3.32e-02	-3.29e-01	1.37e-01
RNA Polymerase I Transcription Termination	30	1.89e-03	-3.28e-01	1.96e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	2.04e-02	3.25e-01	9.76e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency	79	6.78e-07	-3.24e-01	2.02e-05
SRP-dependent cotranslational protein targeting to membrane	89	1.36e-07	-3.24e-01	4.90e-06
IRAK4 deficiency (TLR2/4)	10	7.66e-02	-3.23e-01	2.34e-01
HIV elongation arrest and recovery	32	1.57e-03	-3.23e-01	1.69e-02
Pausing and recovery of HIV elongation	32	1.57e-03	-3.23e-01	1.69e-02
Zinc transporters	12	5.28e-02	3.23e-01	1.82e-01
Mitochondrial iron-sulfur cluster biogenesis	11	6.54e-02	-3.21e-01	2.10e-01
Metabolism of folate and pterines	16	2.79e-02	3.18e-01	1.22e-01
NRAGE signals death through JNK	45	2.67e-04	3.14e-01	3.95e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	13	5.06e-02	3.13e-01	1.78e-01
Interaction between L1 and Ankyrins	12	6.15e-02	3.12e-01	2.01e-01
G beta:gamma signalling through BTK	11	7.74e-02	-3.08e-01	2.35e-01
ATF6 (ATF6-alpha) activates chaperones	12	6.60e-02	3.07e-01	2.11e-01
PI-3K cascade:FGFR1	13	5.60e-02	3.06e-01	1.87e-01
p130Cas linkage to MAPK signaling for integrins	13	5.66e-02	3.05e-01	1.87e-01
Inwardly rectifying K+ channels	16	3.47e-02	-3.05e-01	1.41e-01
Activation of G protein gated Potassium channels	15	4.15e-02	-3.04e-01	1.57e-01
G protein gated Potassium channels	15	4.15e-02	-3.04e-01	1.57e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	15	4.15e-02	-3.04e-01	1.57e-01
Metal ion SLC transporters	18	2.60e-02	3.03e-01	1.15e-01
Spry regulation of FGF signaling	16	3.66e-02	-3.02e-01	1.47e-01
Selenoamino acid metabolism	92	6.22e-07	-3.01e-01	1.89e-05
Hyaluronan metabolism	15	4.46e-02	3.00e-01	1.64e-01
Diseases associated with glycosaminoglycan metabolism	33	2.96e-03	2.99e-01	2.63e-02
SUMOylation of DNA methylation proteins	16	4.12e-02	-2.95e-01	1.57e-01
Signaling by NTRK3 (TRKC)	15	4.89e-02	2.94e-01	1.75e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	8.33e-03	2.93e-01	4.93e-02
Influenza Viral RNA Transcription and Replication	113	7.89e-08	-2.93e-01	3.00e-06
Glycogen storage diseases	13	7.13e-02	-2.89e-01	2.23e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	1.22e-03	-2.89e-01	1.43e-02
HIV Transcription Elongation	42	1.22e-03	-2.89e-01	1.43e-02
Tat-mediated elongation of the HIV-1 transcript	42	1.22e-03	-2.89e-01	1.43e-02
Plasma lipoprotein assembly	12	8.42e-02	-2.88e-01	2.47e-01
ADP signalling through P2Y purinoceptor 1	16	4.69e-02	-2.87e-01	1.69e-01
tRNA Aminoacylation	42	1.33e-03	2.86e-01	1.51e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	1.03e-01	2.84e-01	2.80e-01
alpha-linolenic acid (ALA) metabolism	11	1.03e-01	2.84e-01	2.80e-01
RHOA GTPase cycle	131	2.06e-08	2.84e-01	8.05e-07
RHOB GTPase cycle	64	9.89e-05	2.82e-01	1.63e-03
RHOC GTPase cycle	71	4.24e-05	2.81e-01	7.95e-04
Activation of the AP-1 family of transcription factors	10	1.25e-01	-2.80e-01	3.17e-01
COPI-dependent Golgi-to-ER retrograde traffic	75	2.80e-05	2.80e-01	6.18e-04
G-protein activation	12	9.38e-02	-2.79e-01	2.64e-01
Autodegradation of Cdh1 by Cdh1:APC/C	61	1.69e-04	-2.79e-01	2.65e-03
FGFR2 mutant receptor activation	24	1.83e-02	-2.78e-01	9.14e-02
rRNA processing	188	5.56e-11	-2.78e-01	3.31e-09
Packaging Of Telomere Ends	12	9.61e-02	-2.77e-01	2.69e-01
Resolution of Sister Chromatid Cohesion	102	1.43e-06	2.77e-01	3.91e-05
ATF6 (ATF6-alpha) activates chaperone genes	10	1.30e-01	2.77e-01	3.25e-01
Carnitine metabolism	11	1.13e-01	-2.76e-01	2.98e-01
Regulation of signaling by CBL	16	5.62e-02	2.76e-01	1.87e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	1.60e-03	-2.75e-01	1.71e-02
Role of LAT2/NTAL/LAB on calcium mobilization	13	8.61e-02	2.75e-01	2.51e-01
Regulation of PTEN mRNA translation	11	1.18e-01	2.73e-01	3.06e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	30	1.00e-02	-2.72e-01	5.69e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	19	4.05e-02	-2.72e-01	1.57e-01
Degradation of cysteine and homocysteine	12	1.06e-01	-2.70e-01	2.85e-01
G beta:gamma signalling through CDC42	14	8.18e-02	-2.69e-01	2.43e-01
PI3K Cascade	29	1.27e-02	2.67e-01	6.93e-02
Keratinization	22	3.01e-02	-2.67e-01	1.28e-01
Defective B3GAT3 causes JDSSDHD	17	5.68e-02	2.67e-01	1.88e-01
Signaling by PDGFRA extracellular domain mutants	12	1.10e-01	2.67e-01	2.92e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	1.10e-01	2.67e-01	2.92e-01
RND1 GTPase cycle	37	5.08e-03	2.66e-01	3.56e-02
Extracellular matrix organization	197	1.33e-10	2.66e-01	6.73e-09
IRS-related events triggered by IGF1R	35	6.53e-03	2.66e-01	4.20e-02
FRS-mediated FGFR1 signaling	15	7.49e-02	2.66e-01	2.31e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	22	3.12e-02	-2.65e-01	1.32e-01
Sulfur amino acid metabolism	22	3.13e-02	-2.65e-01	1.32e-01
Glycosaminoglycan metabolism	101	4.47e-06	2.65e-01	1.18e-04
IRS-mediated signalling	33	8.64e-03	2.64e-01	5.03e-02
FGFR1 mutant receptor activation	25	2.23e-02	2.64e-01	1.04e-01
Signaling by FLT3 ITD and TKD mutants	15	7.66e-02	2.64e-01	2.34e-01
Expression and translocation of olfactory receptors	86	2.58e-05	-2.63e-01	5.80e-04
Late endosomal microautophagy	29	1.44e-02	-2.63e-01	7.54e-02
APC/C:Cdc20 mediated degradation of Securin	64	2.88e-04	-2.62e-01	4.19e-03
Negative epigenetic regulation of rRNA expression	56	6.92e-04	-2.62e-01	9.02e-03
Signaling by WNT in cancer	30	1.32e-02	2.62e-01	7.10e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	11	1.34e-01	-2.61e-01	3.28e-01
Gastrulation	10	1.54e-01	2.61e-01	3.57e-01
Germ layer formation at gastrulation	10	1.54e-01	2.61e-01	3.57e-01
RHOD GTPase cycle	50	1.44e-03	2.61e-01	1.61e-02
Frs2-mediated activation	11	1.35e-01	2.61e-01	3.28e-01
RNA Polymerase III Abortive And Retractive Initiation	39	4.89e-03	-2.61e-01	3.51e-02
RNA Polymerase III Transcription	39	4.89e-03	-2.61e-01	3.51e-02
Signaling by ROBO receptors	179	2.03e-09	-2.60e-01	9.60e-08
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	19	4.95e-02	-2.60e-01	1.76e-01
The citric acid (TCA) cycle and respiratory electron transport	170	5.30e-09	-2.60e-01	2.34e-07
NoRC negatively regulates rRNA expression	53	1.15e-03	-2.58e-01	1.41e-02
Synthesis of PIPs at the plasma membrane	46	2.45e-03	2.58e-01	2.30e-02
IGF1R signaling cascade	36	7.41e-03	2.58e-01	4.57e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	36	7.41e-03	2.58e-01	4.57e-02
Chaperone Mediated Autophagy	17	6.61e-02	-2.58e-01	2.11e-01
Vif-mediated degradation of APOBEC3G	50	1.67e-03	-2.57e-01	1.77e-02
ADP signalling through P2Y purinoceptor 12	14	9.71e-02	-2.56e-01	2.70e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	3.10e-05	2.56e-01	6.42e-04
Amplification of signal from the kinetochores	89	3.10e-05	2.56e-01	6.42e-04
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	8.70e-02	-2.55e-01	2.52e-01
Regulation of RUNX1 Expression and Activity	17	6.90e-02	2.55e-01	2.17e-01
ABC transporters in lipid homeostasis	10	1.64e-01	2.54e-01	3.68e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	1.00e-01	-2.54e-01	2.77e-01
WNT ligand biogenesis and trafficking	16	7.95e-02	-2.53e-01	2.40e-01
Postmitotic nuclear pore complex (NPC) reformation	27	2.28e-02	2.53e-01	1.05e-01
NF-kB is activated and signals survival	12	1.29e-01	-2.53e-01	3.25e-01
Negative regulation of NOTCH4 signaling	51	1.85e-03	-2.52e-01	1.93e-02
Formation of the cornified envelope	18	6.41e-02	-2.52e-01	2.06e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	2.06e-03	-2.52e-01	2.04e-02
Integrin signaling	22	4.29e-02	2.49e-01	1.59e-01
Fatty acyl-CoA biosynthesis	29	2.01e-02	2.49e-01	9.70e-02
Vpu mediated degradation of CD4	48	2.85e-03	-2.49e-01	2.59e-02
Assembly and cell surface presentation of NMDA receptors	16	8.50e-02	2.49e-01	2.49e-01
IKK complex recruitment mediated by RIP1	21	4.88e-02	-2.48e-01	1.75e-01
Metabolism of steroids	111	6.69e-06	2.48e-01	1.66e-04
Heparan sulfate/heparin (HS-GAG) metabolism	45	4.18e-03	2.47e-01	3.20e-02
Synthesis of PE	11	1.57e-01	2.47e-01	3.60e-01
RNA Polymerase I Transcription Initiation	47	3.62e-03	-2.46e-01	2.94e-02
PERK regulates gene expression	29	2.25e-02	2.45e-01	1.04e-01
Polo-like kinase mediated events	16	9.01e-02	2.45e-01	2.57e-01
Synthesis of very long-chain fatty acyl-CoAs	18	7.27e-02	2.44e-01	2.26e-01
G alpha (12/13) signalling events	57	1.43e-03	2.44e-01	1.60e-02
SLBP independent Processing of Histone Pre-mRNAs	10	1.82e-01	-2.44e-01	3.89e-01
Signaling by FGFR1 in disease	32	1.72e-02	2.43e-01	8.81e-02
Cell surface interactions at the vascular wall	94	4.64e-05	2.43e-01	8.36e-04
FLT3 signaling in disease	27	2.90e-02	2.43e-01	1.25e-01
Autodegradation of the E3 ubiquitin ligase COP1	48	3.63e-03	-2.43e-01	2.94e-02
EML4 and NUDC in mitotic spindle formation	93	5.31e-05	2.43e-01	9.32e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	3.31e-03	-2.43e-01	2.80e-02
p53-Independent DNA Damage Response	49	3.31e-03	-2.43e-01	2.80e-02
p53-Independent G1/S DNA damage checkpoint	49	3.31e-03	-2.43e-01	2.80e-02
Synthesis of IP2, IP, and Ins in the cytosol	12	1.46e-01	2.42e-01	3.46e-01
Signaling by cytosolic FGFR1 fusion mutants	18	7.64e-02	2.41e-01	2.34e-01
ATF4 activates genes in response to endoplasmic reticulum stress	24	4.09e-02	2.41e-01	1.57e-01
Translation	267	1.42e-11	-2.41e-01	9.73e-10
FCERI mediated Ca+2 mobilization	21	5.65e-02	2.40e-01	1.87e-01
Plasma lipoprotein clearance	30	2.28e-02	2.40e-01	1.05e-01
Early SARS-CoV-2 Infection Events	29	2.54e-02	2.40e-01	1.14e-01
Recycling pathway of L1	24	4.23e-02	2.40e-01	1.59e-01
Degradation of DVL	53	2.61e-03	-2.39e-01	2.40e-02
Retinoid metabolism and transport	24	4.28e-02	2.39e-01	1.59e-01
Olfactory Signaling Pathway	90	9.57e-05	-2.38e-01	1.60e-03
Inactivation of CSF3 (G-CSF) signaling	21	5.92e-02	-2.38e-01	1.94e-01
Oncogenic MAPK signaling	73	4.59e-04	2.37e-01	6.28e-03
Depolymerisation of the Nuclear Lamina	14	1.25e-01	2.37e-01	3.17e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	47	5.15e-03	-2.36e-01	3.59e-02
Integrin cell surface interactions	44	6.80e-03	2.36e-01	4.27e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	1.97e-01	2.35e-01	4.12e-01
Apoptotic execution phase	42	8.37e-03	2.35e-01	4.93e-02
SCF-beta-TrCP mediated degradation of Emi1	52	3.37e-03	-2.35e-01	2.82e-02
APC-Cdc20 mediated degradation of Nek2A	25	4.22e-02	-2.35e-01	1.59e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	21	6.26e-02	2.35e-01	2.04e-01
Major pathway of rRNA processing in the nucleolus and cytosol	157	4.62e-07	-2.34e-01	1.51e-05
NCAM signaling for neurite out-growth	41	9.73e-03	2.33e-01	5.55e-02
rRNA processing in the nucleus and cytosol	167	2.08e-07	-2.33e-01	7.29e-06
Cobalamin (Cbl, vitamin B12) transport and metabolism	15	1.18e-01	2.33e-01	3.06e-01
Collagen degradation	20	7.12e-02	2.33e-01	2.23e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.82e-01	-2.33e-01	3.89e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	70	7.97e-04	-2.32e-01	1.02e-02
mRNA Splicing - Minor Pathway	50	4.57e-03	-2.32e-01	3.39e-02
Polymerase switching on the C-strand of the telomere	25	4.49e-02	-2.32e-01	1.64e-01
Glutathione synthesis and recycling	10	2.05e-01	2.32e-01	4.17e-01
VEGFR2 mediated cell proliferation	16	1.09e-01	2.32e-01	2.90e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	51	4.50e-03	-2.30e-01	3.38e-02
APC/C:Cdc20 mediated degradation of Cyclin B	23	5.62e-02	-2.30e-01	1.87e-01
Unwinding of DNA	12	1.68e-01	2.30e-01	3.72e-01
TRAF3-dependent IRF activation pathway	12	1.69e-01	2.29e-01	3.72e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	57	2.86e-03	-2.29e-01	2.59e-02
Signaling by BRAF and RAF1 fusions	57	2.88e-03	2.28e-01	2.59e-02
RNA Polymerase III Chain Elongation	16	1.14e-01	-2.28e-01	2.98e-01
ERKs are inactivated	12	1.71e-01	-2.28e-01	3.76e-01
Influenza Infection	130	7.59e-06	-2.28e-01	1.82e-04
Degradation of GLI1 by the proteasome	55	3.80e-03	-2.26e-01	3.06e-02
Export of Viral Ribonucleoproteins from Nucleus	32	2.72e-02	2.26e-01	1.19e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	4.92e-03	-2.26e-01	3.51e-02
RHO GTPases Activate Formins	115	3.14e-05	2.25e-01	6.42e-04
CTNNB1 S33 mutants aren’t phosphorylated	15	1.32e-01	2.25e-01	3.25e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	1.32e-01	2.25e-01	3.25e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	1.32e-01	2.25e-01	3.25e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	1.32e-01	2.25e-01	3.25e-01
Signaling by CTNNB1 phospho-site mutants	15	1.32e-01	2.25e-01	3.25e-01
Signaling by GSK3beta mutants	15	1.32e-01	2.25e-01	3.25e-01
Transport of bile salts and organic acids, metal ions and amine compounds	46	8.48e-03	2.24e-01	4.96e-02
Regulation of Apoptosis	50	6.25e-03	-2.24e-01	4.09e-02
Downstream signaling of activated FGFR1	23	6.36e-02	2.24e-01	2.06e-01
PI-3K cascade:FGFR3	11	2.01e-01	2.23e-01	4.15e-01
PI-3K cascade:FGFR4	11	2.01e-01	2.23e-01	4.15e-01
Insulin receptor signalling cascade	38	1.81e-02	2.22e-01	9.06e-02
Effects of PIP2 hydrolysis	18	1.04e-01	2.22e-01	2.82e-01
Mitochondrial protein import	56	4.17e-03	-2.22e-01	3.20e-02
RHO GTPases activate CIT	17	1.14e-01	2.21e-01	2.98e-01
SIRT1 negatively regulates rRNA expression	15	1.38e-01	-2.21e-01	3.34e-01
Ubiquitin-dependent degradation of Cyclin D	49	7.47e-03	-2.21e-01	4.57e-02
RNA Polymerase I Promoter Escape	38	1.89e-02	-2.20e-01	9.35e-02
RNA Polymerase I Promoter Clearance	57	4.08e-03	-2.20e-01	3.16e-02
RNA Polymerase I Transcription	57	4.08e-03	-2.20e-01	3.16e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation	29	4.13e-02	2.19e-01	1.57e-01
Dectin-1 mediated noncanonical NF-kB signaling	57	4.27e-03	-2.19e-01	3.25e-02
CDK-mediated phosphorylation and removal of Cdc6	68	1.82e-03	-2.19e-01	1.91e-02
Mitochondrial Fatty Acid Beta-Oxidation	32	3.23e-02	-2.19e-01	1.35e-01
NRIF signals cell death from the nucleus	15	1.43e-01	-2.19e-01	3.42e-01
RHOG GTPase cycle	65	2.33e-03	2.19e-01	2.23e-02
DAG and IP3 signaling	32	3.27e-02	2.18e-01	1.36e-01
Hh mutants are degraded by ERAD	52	6.52e-03	-2.18e-01	4.20e-02
SCF(Skp2)-mediated degradation of p27/p21	57	4.44e-03	-2.18e-01	3.36e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	61	3.30e-03	-2.18e-01	2.80e-02
Stabilization of p53	52	6.68e-03	-2.18e-01	4.21e-02
p53-Dependent G1 DNA Damage Response	60	3.59e-03	-2.18e-01	2.94e-02
p53-Dependent G1/S DNA damage checkpoint	60	3.59e-03	-2.18e-01	2.94e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	2.35e-01	2.17e-01	4.58e-01
Protein methylation	15	1.46e-01	-2.17e-01	3.46e-01
Cytoprotection by HMOX1	57	4.84e-03	-2.16e-01	3.51e-02
Mitophagy	25	6.39e-02	-2.14e-01	2.06e-01
FGFR2 alternative splicing	25	6.48e-02	-2.13e-01	2.08e-01
IRAK2 mediated activation of TAK1 complex	10	2.43e-01	-2.13e-01	4.67e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	21	9.15e-02	2.13e-01	2.60e-01
Interferon gamma signaling	51	8.69e-03	-2.13e-01	5.04e-02
Negative regulation of FLT3	12	2.02e-01	-2.13e-01	4.15e-01
PI Metabolism	71	2.00e-03	2.12e-01	2.01e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	68	2.50e-03	-2.12e-01	2.32e-02
CS/DS degradation	13	1.86e-01	2.12e-01	3.96e-01
Nuclear Pore Complex (NPC) Disassembly	35	3.12e-02	2.11e-01	1.32e-01
Triglyceride metabolism	21	9.51e-02	2.10e-01	2.67e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	14	1.73e-01	-2.10e-01	3.78e-01
Golgi-to-ER retrograde transport	105	2.01e-04	2.10e-01	3.13e-03
Formation of TC-NER Pre-Incision Complex	53	8.30e-03	-2.10e-01	4.93e-02
NIK–>noncanonical NF-kB signaling	56	6.67e-03	-2.10e-01	4.21e-02
PLC beta mediated events	36	2.99e-02	2.09e-01	1.28e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	20	1.08e-01	-2.08e-01	2.88e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	20	1.08e-01	-2.08e-01	2.88e-01
Factors involved in megakaryocyte development and platelet production	102	2.97e-04	2.08e-01	4.28e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	19	1.18e-01	-2.07e-01	3.06e-01
Degradation of GLI2 by the proteasome	55	7.97e-03	-2.07e-01	4.76e-02
CDC42 GTPase cycle	131	4.55e-05	2.07e-01	8.30e-04
Regulation of IFNG signaling	12	2.16e-01	-2.06e-01	4.34e-01
Dermatan sulfate biosynthesis	10	2.59e-01	2.06e-01	4.84e-01
Transport of Ribonucleoproteins into the Host Nucleus	31	4.75e-02	2.06e-01	1.70e-01
Basigin interactions	20	1.13e-01	2.05e-01	2.98e-01
Formation of RNA Pol II elongation complex	57	7.93e-03	-2.04e-01	4.76e-02
RNA Polymerase II Transcription Elongation	57	7.93e-03	-2.04e-01	4.76e-02
Nucleotide biosynthesis	12	2.23e-01	2.03e-01	4.39e-01
G1/S DNA Damage Checkpoints	62	5.67e-03	-2.03e-01	3.82e-02
Cleavage of the damaged purine	16	1.59e-01	-2.03e-01	3.61e-01
Depurination	16	1.59e-01	-2.03e-01	3.61e-01
Recognition and association of DNA glycosylase with site containing an affected purine	16	1.59e-01	-2.03e-01	3.61e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	38	3.03e-02	-2.03e-01	1.29e-01
NEP/NS2 Interacts with the Cellular Export Machinery	31	5.20e-02	2.02e-01	1.81e-01
Formation of tubulin folding intermediates by CCT/TriC	18	1.39e-01	2.02e-01	3.36e-01
IRF3-mediated induction of type I IFN	11	2.47e-01	-2.02e-01	4.72e-01
Beta-catenin phosphorylation cascade	17	1.52e-01	2.01e-01	3.56e-01
Sensory processing of sound	41	2.66e-02	2.00e-01	1.17e-01
Hh mutants abrogate ligand secretion	53	1.18e-02	-2.00e-01	6.56e-02
Role of phospholipids in phagocytosis	19	1.32e-01	2.00e-01	3.25e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	3.91e-02	-1.99e-01	1.53e-01
MET activates RAP1 and RAC1	10	2.77e-01	1.99e-01	5.01e-01
HIV Transcription Initiation	46	2.01e-02	-1.98e-01	9.70e-02
RNA Polymerase II HIV Promoter Escape	46	2.01e-02	-1.98e-01	9.70e-02
RNA Polymerase II Promoter Escape	46	2.01e-02	-1.98e-01	9.70e-02
RNA Polymerase II Transcription Initiation	46	2.01e-02	-1.98e-01	9.70e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	46	2.01e-02	-1.98e-01	9.70e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	46	2.01e-02	-1.98e-01	9.70e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	1.46e-01	-1.98e-01	3.46e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	22	1.08e-01	1.98e-01	2.89e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	69	4.60e-03	-1.97e-01	3.39e-02
Regulation of TP53 Activity through Association with Co-factors	10	2.81e-01	-1.97e-01	5.06e-01
RHOV GTPase cycle	35	4.41e-02	1.97e-01	1.63e-01
Intrinsic Pathway of Fibrin Clot Formation	11	2.59e-01	-1.97e-01	4.84e-01
PI-3K cascade:FGFR2	14	2.04e-01	1.96e-01	4.17e-01
NCAM1 interactions	23	1.05e-01	1.96e-01	2.83e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	76	3.26e-03	1.95e-01	2.80e-02
Nitric oxide stimulates guanylate cyclase	10	2.86e-01	1.95e-01	5.11e-01
Platelet Aggregation (Plug Formation)	27	8.07e-02	1.94e-01	2.40e-01
HS-GAG biosynthesis	25	9.29e-02	1.94e-01	2.63e-01
Rev-mediated nuclear export of HIV RNA	34	5.02e-02	1.94e-01	1.78e-01
DNA Damage Recognition in GG-NER	38	3.85e-02	-1.94e-01	1.52e-01
Signaling by PDGF	44	2.60e-02	1.94e-01	1.15e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	26	8.70e-02	-1.94e-01	2.52e-01
RNA Polymerase III Transcription Initiation	34	5.05e-02	-1.94e-01	1.78e-01
NS1 Mediated Effects on Host Pathways	38	3.91e-02	1.93e-01	1.53e-01
Cross-presentation of soluble exogenous antigens (endosomes)	43	2.83e-02	-1.93e-01	1.23e-01
Azathioprine ADME	18	1.56e-01	1.93e-01	3.60e-01
Signaling by Hippo	20	1.35e-01	1.93e-01	3.28e-01
GLI3 is processed to GLI3R by the proteasome	56	1.25e-02	-1.93e-01	6.83e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	26	8.84e-02	-1.93e-01	2.56e-01
Removal of the Flap Intermediate from the C-strand	16	1.81e-01	-1.93e-01	3.89e-01
Transcription of the HIV genome	68	5.97e-03	-1.93e-01	3.95e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	71	4.98e-03	-1.93e-01	3.53e-02
SUMOylation of DNA replication proteins	44	2.71e-02	1.93e-01	1.19e-01
RHOF GTPase cycle	39	3.76e-02	1.92e-01	1.49e-01
RND2 GTPase cycle	38	4.03e-02	1.92e-01	1.57e-01
Synthesis of PA	26	8.99e-02	-1.92e-01	2.57e-01
FCERI mediated NF-kB activation	71	5.20e-03	-1.92e-01	3.59e-02
Regulation of RUNX2 expression and activity	66	7.19e-03	-1.92e-01	4.47e-02
Cellular response to starvation	127	2.06e-04	-1.91e-01	3.17e-03
DNA methylation	11	2.73e-01	1.91e-01	4.98e-01
L1CAM interactions	74	4.61e-03	1.91e-01	3.39e-02
Glyoxylate metabolism and glycine degradation	23	1.14e-01	-1.91e-01	2.98e-01
RNA Polymerase I Promoter Opening	10	2.97e-01	-1.91e-01	5.23e-01
Unfolded Protein Response (UPR)	86	2.32e-03	1.90e-01	2.23e-02
Other semaphorin interactions	15	2.03e-01	1.90e-01	4.15e-01
mRNA Splicing	184	9.84e-06	-1.90e-01	2.28e-04
Signaling by MET	56	1.44e-02	1.89e-01	7.54e-02
FRS-mediated FGFR3 signaling	13	2.39e-01	1.89e-01	4.61e-01
FRS-mediated FGFR4 signaling	13	2.39e-01	1.89e-01	4.61e-01
NR1H2 and NR1H3-mediated signaling	35	5.38e-02	1.88e-01	1.83e-01
Signaling by FGFR4 in disease	10	3.02e-01	1.88e-01	5.29e-01
Retrograde neurotrophin signalling	11	2.81e-01	1.88e-01	5.06e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	10	3.04e-01	1.88e-01	5.29e-01
RAC1 GTPase cycle	154	6.23e-05	1.87e-01	1.08e-03
Metabolism of RNA	636	1.46e-15	-1.87e-01	1.99e-12
Tie2 Signaling	16	1.95e-01	1.87e-01	4.10e-01
Signalling to RAS	16	1.96e-01	-1.87e-01	4.11e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	2.85e-01	-1.86e-01	5.11e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	31	7.33e-02	1.86e-01	2.28e-01
Sensory processing of sound by inner hair cells of the cochlea	39	4.48e-02	1.86e-01	1.64e-01
p75NTR signals via NF-kB	15	2.13e-01	-1.86e-01	4.31e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	8.38e-02	1.86e-01	2.47e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	8.38e-02	1.86e-01	2.47e-01
Nuclear Envelope Breakdown	50	2.36e-02	1.85e-01	1.07e-01
Senescence-Associated Secretory Phenotype (SASP)	52	2.11e-02	-1.85e-01	9.97e-02
Signal amplification	21	1.43e-01	-1.85e-01	3.43e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	72	6.97e-03	-1.84e-01	4.35e-02
Interactions of Rev with host cellular proteins	36	5.62e-02	1.84e-01	1.87e-01
Post-translational protein phosphorylation	70	7.90e-03	1.84e-01	4.76e-02
Pregnenolone biosynthesis	10	3.14e-01	1.84e-01	5.36e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	67	9.42e-03	1.84e-01	5.42e-02
Downstream signal transduction	28	9.28e-02	1.84e-01	2.63e-01
Glycolysis	64	1.12e-02	1.84e-01	6.23e-02
Sphingolipid de novo biosynthesis	37	5.38e-02	1.83e-01	1.83e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	15	2.21e-01	1.83e-01	4.39e-01
Regulation of APC/C activators between G1/S and early anaphase	76	6.08e-03	-1.82e-01	4.00e-02
O-linked glycosylation of mucins	34	6.64e-02	1.82e-01	2.11e-01
Activation of NF-kappaB in B cells	62	1.33e-02	-1.82e-01	7.12e-02
Acyl chain remodelling of PC	14	2.39e-01	-1.82e-01	4.61e-01
mRNA Splicing - Major Pathway	176	3.34e-05	-1.82e-01	6.53e-04
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	8.54e-02	-1.82e-01	2.50e-01
SHC-mediated cascade:FGFR1	13	2.58e-01	1.81e-01	4.84e-01
Metabolism of fat-soluble vitamins	27	1.04e-01	1.81e-01	2.82e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.59e-01	1.81e-01	4.84e-01
Condensation of Prophase Chromosomes	19	1.73e-01	1.81e-01	3.78e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	86	3.83e-03	1.81e-01	3.06e-02
GPVI-mediated activation cascade	22	1.44e-01	1.80e-01	3.44e-01
Formation of Incision Complex in GG-NER	42	4.46e-02	-1.79e-01	1.64e-01
Growth hormone receptor signaling	20	1.65e-01	-1.79e-01	3.68e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.07e-01	1.79e-01	2.88e-01
TICAM1-dependent activation of IRF3/IRF7	12	2.83e-01	-1.79e-01	5.08e-01
Degradation of beta-catenin by the destruction complex	82	5.18e-03	-1.79e-01	3.59e-02
Cyclin A:Cdk2-associated events at S phase entry	82	5.29e-03	-1.78e-01	3.62e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	16	2.17e-01	-1.78e-01	4.34e-01
TRAF6 mediated IRF7 activation	14	2.49e-01	1.78e-01	4.74e-01
p75NTR recruits signalling complexes	12	2.87e-01	-1.77e-01	5.13e-01
G-protein mediated events	40	5.22e-02	1.77e-01	1.81e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	25	1.25e-01	1.77e-01	3.17e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	25	1.25e-01	1.77e-01	3.17e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	1.25e-01	1.77e-01	3.17e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	1.25e-01	1.77e-01	3.17e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	167	8.29e-05	1.77e-01	1.42e-03
SLC transporter disorders	66	1.31e-02	1.77e-01	7.07e-02
MAPK6/MAPK4 signaling	84	5.22e-03	-1.77e-01	3.59e-02
Nuclear import of Rev protein	33	8.01e-02	1.76e-01	2.40e-01
Mitotic Prometaphase	183	4.24e-05	1.76e-01	7.95e-04
Cyclin E associated events during G1/S transition	80	6.61e-03	-1.76e-01	4.21e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	2.40e-01	-1.75e-01	4.62e-01
Mitotic Spindle Checkpoint	105	1.94e-03	1.75e-01	1.97e-02
Defects in cobalamin (B12) metabolism	12	2.93e-01	1.75e-01	5.19e-01
Inactivation, recovery and regulation of the phototransduction cascade	21	1.65e-01	-1.75e-01	3.68e-01
The phototransduction cascade	21	1.65e-01	-1.75e-01	3.68e-01
CD28 dependent PI3K/Akt signaling	19	1.87e-01	1.75e-01	3.96e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	565	2.45e-12	1.74e-01	3.35e-10
Thromboxane signalling through TP receptor	14	2.60e-01	-1.74e-01	4.86e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	33	8.42e-02	1.74e-01	2.47e-01
APC truncation mutants have impaired AXIN binding	14	2.65e-01	1.72e-01	4.88e-01
AXIN missense mutants destabilize the destruction complex	14	2.65e-01	1.72e-01	4.88e-01
Signaling by AMER1 mutants	14	2.65e-01	1.72e-01	4.88e-01
Signaling by APC mutants	14	2.65e-01	1.72e-01	4.88e-01
Signaling by AXIN mutants	14	2.65e-01	1.72e-01	4.88e-01
Truncations of AMER1 destabilize the destruction complex	14	2.65e-01	1.72e-01	4.88e-01
FRS-mediated FGFR2 signaling	16	2.34e-01	1.72e-01	4.57e-01
Defects in vitamin and cofactor metabolism	20	1.83e-01	1.72e-01	3.91e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	15	2.50e-01	-1.72e-01	4.74e-01
Signaling by Rho GTPases	551	1.01e-11	1.71e-01	8.13e-10
Signaling by NOTCH4	77	9.56e-03	-1.71e-01	5.47e-02
Interactions of Vpr with host cellular proteins	33	9.01e-02	1.71e-01	2.57e-01
Regulation of RUNX3 expression and activity	52	3.47e-02	-1.69e-01	1.41e-01
RHO GTPase cycle	386	1.45e-08	1.69e-01	5.99e-07
Translesion synthesis by POLI	17	2.28e-01	-1.69e-01	4.48e-01
Activation of HOX genes during differentiation	66	1.80e-02	-1.69e-01	9.03e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	66	1.80e-02	-1.69e-01	9.03e-02
Signaling by Erythropoietin	22	1.72e-01	1.68e-01	3.76e-01
Downstream signaling of activated FGFR3	18	2.17e-01	1.68e-01	4.34e-01
Downstream signaling of activated FGFR4	18	2.17e-01	1.68e-01	4.34e-01
Regulation of TLR by endogenous ligand	11	3.35e-01	-1.68e-01	5.53e-01
SUMOylation of immune response proteins	11	3.37e-01	-1.67e-01	5.55e-01
Elevation of cytosolic Ca2+ levels	12	3.16e-01	1.67e-01	5.38e-01
Vpr-mediated nuclear import of PICs	32	1.03e-01	1.67e-01	2.80e-01
Negative regulation of FGFR3 signaling	22	1.77e-01	-1.67e-01	3.82e-01
Negative regulation of FGFR4 signaling	22	1.77e-01	-1.67e-01	3.82e-01
Hedgehog ligand biogenesis	55	3.33e-02	-1.66e-01	1.37e-01
SLC-mediated transmembrane transport	141	7.17e-04	1.65e-01	9.26e-03
G alpha (z) signalling events	33	1.00e-01	-1.65e-01	2.77e-01
RNA polymerase II transcribes snRNA genes	71	1.61e-02	-1.65e-01	8.34e-02
Interleukin-20 family signaling	14	2.86e-01	1.65e-01	5.11e-01
ER-Phagosome pathway	72	1.58e-02	-1.65e-01	8.25e-02
Degradation of AXIN	52	4.08e-02	-1.64e-01	1.57e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	3.06e-01	-1.64e-01	5.30e-01
RNA Polymerase II Transcription Termination	65	2.24e-02	-1.64e-01	1.04e-01
Impaired BRCA2 binding to PALB2	24	1.65e-01	1.64e-01	3.68e-01
AURKA Activation by TPX2	71	1.71e-02	1.64e-01	8.77e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	83	1.02e-02	-1.63e-01	5.72e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	25	1.57e-01	-1.63e-01	3.61e-01
Condensation of Prometaphase Chromosomes	11	3.48e-01	1.63e-01	5.70e-01
Sphingolipid metabolism	71	1.77e-02	1.63e-01	8.99e-02
Resolution of D-Loop Structures	34	1.01e-01	1.63e-01	2.77e-01
Switching of origins to a post-replicative state	87	9.04e-03	-1.62e-01	5.22e-02
Interferon alpha/beta signaling	37	8.88e-02	-1.62e-01	2.56e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	77	1.43e-02	-1.62e-01	7.54e-02
Assembly of active LPL and LIPC lipase complexes	10	3.77e-01	1.61e-01	6.03e-01
Interconversion of nucleotide di- and triphosphates	25	1.63e-01	1.61e-01	3.67e-01
Metabolism of polyamines	55	3.90e-02	-1.61e-01	1.53e-01
Metabolism of carbohydrates	242	1.86e-05	1.60e-01	4.25e-04
G beta:gamma signalling through PLC beta	13	3.18e-01	-1.60e-01	5.38e-01
Presynaptic function of Kainate receptors	13	3.18e-01	-1.60e-01	5.38e-01
Metabolism of amino acids and derivatives	273	5.92e-06	-1.60e-01	1.53e-04
Platelet Adhesion to exposed collagen	10	3.82e-01	1.60e-01	6.05e-01
Defective CFTR causes cystic fibrosis	58	3.65e-02	-1.59e-01	1.47e-01
IRE1alpha activates chaperones	49	5.47e-02	1.59e-01	1.85e-01
Downstream signaling of activated FGFR2	21	2.10e-01	1.58e-01	4.25e-01
Neurotransmitter release cycle	28	1.49e-01	1.58e-01	3.51e-01
PKMTs methylate histone lysines	43	7.40e-02	1.58e-01	2.29e-01
RORA activates gene expression	17	2.62e-01	1.57e-01	4.87e-01
Activation of SMO	14	3.11e-01	1.56e-01	5.34e-01
APC/C-mediated degradation of cell cycle proteins	83	1.39e-02	-1.56e-01	7.39e-02
Regulation of mitotic cell cycle	83	1.39e-02	-1.56e-01	7.39e-02
Signal transduction by L1	21	2.16e-01	1.56e-01	4.34e-01
Signaling by Leptin	10	3.93e-01	1.56e-01	6.11e-01
TBC/RABGAPs	42	8.03e-02	-1.56e-01	2.40e-01
Protein localization	139	1.54e-03	-1.56e-01	1.69e-02
Mitochondrial biogenesis	88	1.22e-02	-1.55e-01	6.72e-02
Nucleotide Excision Repair	108	5.55e-03	-1.55e-01	3.76e-02
Processing of Capped Intron-Containing Pre-mRNA	234	4.93e-05	-1.55e-01	8.76e-04
RNA Polymerase II Pre-transcription Events	79	1.78e-02	-1.54e-01	9.01e-02
ERBB2 Activates PTK6 Signaling	11	3.77e-01	-1.54e-01	6.03e-01
Acyl chain remodelling of PS	12	3.58e-01	-1.53e-01	5.81e-01
Regulation of ornithine decarboxylase (ODC)	48	6.63e-02	-1.53e-01	2.11e-01
RHO GTPases activate PAKs	19	2.48e-01	1.53e-01	4.72e-01
Translesion synthesis by REV1	16	2.90e-01	-1.53e-01	5.16e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	1.18e-01	1.53e-01	3.06e-01
Downstream signaling events of B Cell Receptor (BCR)	73	2.51e-02	-1.52e-01	1.13e-01
Pentose phosphate pathway	14	3.26e-01	1.52e-01	5.46e-01
Glutathione conjugation	28	1.66e-01	-1.51e-01	3.69e-01
RHOJ GTPase cycle	51	6.22e-02	1.51e-01	2.03e-01
RHOU GTPase cycle	39	1.03e-01	1.51e-01	2.81e-01
ABC transporter disorders	66	3.44e-02	-1.51e-01	1.41e-01
Miscellaneous transport and binding events	22	2.22e-01	1.50e-01	4.39e-01
Global Genome Nucleotide Excision Repair (GG-NER)	82	1.87e-02	-1.50e-01	9.28e-02
Cargo concentration in the ER	24	2.02e-01	1.50e-01	4.15e-01
PINK1-PRKN Mediated Mitophagy	18	2.70e-01	-1.50e-01	4.94e-01
ER Quality Control Compartment (ERQC)	21	2.35e-01	1.50e-01	4.58e-01
mRNA 3’-end processing	56	5.33e-02	-1.49e-01	1.83e-01
Signaling by FGFR3 in disease	15	3.17e-01	1.49e-01	5.38e-01
Interleukin receptor SHC signaling	16	3.02e-01	1.49e-01	5.29e-01
Signaling by Insulin receptor	57	5.20e-02	1.49e-01	1.81e-01
Activation of the pre-replicative complex	32	1.45e-01	1.49e-01	3.45e-01
Orc1 removal from chromatin	67	3.59e-02	-1.48e-01	1.46e-01
CaM pathway	26	1.91e-01	1.48e-01	4.02e-01
Calmodulin induced events	26	1.91e-01	1.48e-01	4.02e-01
RMTs methylate histone arginines	33	1.41e-01	-1.48e-01	3.39e-01
TP53 Regulates Transcription of DNA Repair Genes	61	4.57e-02	-1.48e-01	1.66e-01
Regulation of TP53 Activity through Acetylation	29	1.68e-01	-1.48e-01	3.72e-01
Assembly of the pre-replicative complex	87	1.73e-02	-1.48e-01	8.82e-02
Alpha-protein kinase 1 signaling pathway	11	3.96e-01	-1.48e-01	6.12e-01
Transport of the SLBP independent Mature mRNA	34	1.37e-01	1.48e-01	3.32e-01
Glycogen synthesis	12	3.79e-01	-1.47e-01	6.04e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	12	3.81e-01	1.46e-01	6.05e-01
Hemostasis	410	4.75e-07	1.46e-01	1.51e-05
VEGFR2 mediated vascular permeability	24	2.16e-01	1.46e-01	4.34e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	2.62e-01	1.45e-01	4.87e-01
MECP2 regulates neuronal receptors and channels	10	4.28e-01	-1.45e-01	6.41e-01
Pyroptosis	17	3.03e-01	-1.44e-01	5.29e-01
Telomere Extension By Telomerase	22	2.42e-01	-1.44e-01	4.65e-01
Sema4D induced cell migration and growth-cone collapse	18	2.91e-01	1.44e-01	5.16e-01
Inositol phosphate metabolism	37	1.31e-01	1.44e-01	3.25e-01
Signaling by high-kinase activity BRAF mutants	30	1.74e-01	1.44e-01	3.79e-01
Downregulation of ERBB2:ERBB3 signaling	13	3.70e-01	-1.44e-01	5.95e-01
HCMV Early Events	61	5.30e-02	1.43e-01	1.82e-01
RHO GTPase Effectors	221	2.66e-04	1.43e-01	3.95e-03
Base-Excision Repair, AP Site Formation	23	2.37e-01	-1.42e-01	4.61e-01
Loss of Nlp from mitotic centrosomes	68	4.29e-02	1.42e-01	1.59e-01
Loss of proteins required for interphase microtubule organization from the centrosome	68	4.29e-02	1.42e-01	1.59e-01
Regulation of RAS by GAPs	63	5.27e-02	-1.41e-01	1.82e-01
Downstream TCR signaling	77	3.24e-02	-1.41e-01	1.35e-01
Signaling by FGFR2 in disease	34	1.55e-01	-1.41e-01	3.59e-01
RND3 GTPase cycle	36	1.44e-01	1.41e-01	3.44e-01
tRNA processing	118	8.41e-03	-1.41e-01	4.94e-02
Myogenesis	20	2.77e-01	1.41e-01	5.01e-01
G1/S-Specific Transcription	28	1.99e-01	1.40e-01	4.15e-01
Cell death signalling via NRAGE, NRIF and NADE	62	5.63e-02	1.40e-01	1.87e-01
Transport of the SLBP Dependant Mature mRNA	35	1.52e-01	1.40e-01	3.56e-01
Glycosphingolipid metabolism	34	1.58e-01	1.40e-01	3.61e-01
Sensory perception of taste	10	4.48e-01	1.39e-01	6.61e-01
RHO GTPases Activate ROCKs	17	3.22e-01	1.39e-01	5.42e-01
Apoptotic cleavage of cellular proteins	31	1.83e-01	1.38e-01	3.90e-01
Synaptic adhesion-like molecules	15	3.56e-01	-1.38e-01	5.79e-01
Adrenaline,noradrenaline inhibits insulin secretion	19	2.99e-01	-1.38e-01	5.25e-01
G alpha (s) signalling events	62	6.15e-02	1.37e-01	2.01e-01
Processive synthesis on the C-strand of the telomere	18	3.13e-01	-1.37e-01	5.35e-01
RHO GTPases activate PKNs	36	1.54e-01	1.37e-01	3.58e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	67	5.45e-02	-1.36e-01	1.85e-01
Nucleotide catabolism	27	2.25e-01	-1.35e-01	4.44e-01
Negative regulation of FGFR2 signaling	25	2.44e-01	-1.35e-01	4.67e-01
Cellular response to hypoxia	69	5.39e-02	-1.34e-01	1.83e-01
EPHA-mediated growth cone collapse	12	4.21e-01	1.34e-01	6.36e-01
Metabolism of porphyrins	19	3.12e-01	-1.34e-01	5.35e-01
Potassium Channels	37	1.59e-01	-1.34e-01	3.61e-01
Heme signaling	40	1.45e-01	1.33e-01	3.44e-01
Signaling by NTRK2 (TRKB)	20	3.04e-01	1.33e-01	5.29e-01
Formation of Fibrin Clot (Clotting Cascade)	18	3.30e-01	-1.33e-01	5.48e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	4.70e-01	1.32e-01	6.73e-01
Regulation of FZD by ubiquitination	18	3.34e-01	1.32e-01	5.51e-01
Cell-extracellular matrix interactions	16	3.63e-01	1.32e-01	5.87e-01
Glucose metabolism	80	4.25e-02	1.31e-01	1.59e-01
Regulation of BACH1 activity	11	4.51e-01	-1.31e-01	6.65e-01
Signaling by FGFR2	61	7.67e-02	-1.31e-01	2.34e-01
Transport to the Golgi and subsequent modification	141	7.86e-03	1.30e-01	4.76e-02
Pyruvate metabolism	27	2.43e-01	1.30e-01	4.67e-01
Gluconeogenesis	27	2.44e-01	1.30e-01	4.67e-01
HIV Infection	209	1.29e-03	-1.30e-01	1.48e-02
Maturation of nucleoprotein	11	4.57e-01	-1.29e-01	6.68e-01
STING mediated induction of host immune responses	14	4.03e-01	-1.29e-01	6.17e-01
Regulation of KIT signaling	13	4.21e-01	-1.29e-01	6.36e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	4.81e-01	1.29e-01	6.85e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	12	4.41e-01	1.29e-01	6.54e-01
Phosphorylation of the APC/C	19	3.32e-01	-1.28e-01	5.49e-01
Cellular response to chemical stress	170	4.01e-03	-1.28e-01	3.15e-02
Keratan sulfate/keratin metabolism	26	2.58e-01	1.28e-01	4.84e-01
Dual Incision in GG-NER	40	1.61e-01	-1.28e-01	3.63e-01
Transcriptional Regulation by VENTX	35	1.90e-01	-1.28e-01	4.02e-01
Gastrin-CREB signalling pathway via PKC and MAPK	15	3.91e-01	-1.28e-01	6.11e-01
Metabolism of water-soluble vitamins and cofactors	105	2.38e-02	1.28e-01	1.08e-01
RAC2 GTPase cycle	76	5.53e-02	1.27e-01	1.86e-01
SUMOylation of transcription factors	15	3.94e-01	-1.27e-01	6.11e-01
Transcriptional regulation by RUNX3	91	3.65e-02	-1.27e-01	1.47e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	27	2.55e-01	1.27e-01	4.82e-01
Anti-inflammatory response favouring Leishmania parasite infection	65	7.80e-02	1.27e-01	2.36e-01
Leishmania parasite growth and survival	65	7.80e-02	1.27e-01	2.36e-01
SHC1 events in ERBB2 signaling	20	3.29e-01	-1.26e-01	5.48e-01
Late Phase of HIV Life Cycle	131	1.30e-02	-1.26e-01	7.07e-02
Initiation of Nuclear Envelope (NE) Reformation	18	3.55e-01	1.26e-01	5.79e-01
XBP1(S) activates chaperone genes	47	1.37e-01	1.26e-01	3.32e-01
Synthesis of DNA	115	2.05e-02	-1.25e-01	9.77e-02
Signaling by RAF1 mutants	35	2.00e-01	1.25e-01	4.15e-01
TCR signaling	91	4.04e-02	-1.25e-01	1.57e-01
Asymmetric localization of PCP proteins	61	9.29e-02	-1.25e-01	2.63e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	35	2.05e-01	-1.24e-01	4.17e-01
RAC3 GTPase cycle	79	5.73e-02	1.24e-01	1.88e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	1.76e-01	1.24e-01	3.82e-01
Metabolism of vitamins and cofactors	146	1.04e-02	1.23e-01	5.82e-02
Cleavage of the damaged pyrimidine	21	3.29e-01	-1.23e-01	5.48e-01
Depyrimidination	21	3.29e-01	-1.23e-01	5.48e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	21	3.29e-01	-1.23e-01	5.48e-01
Signaling by CSF3 (G-CSF)	26	2.78e-01	-1.23e-01	5.03e-01
Telomere C-strand (Lagging Strand) Synthesis	33	2.22e-01	-1.23e-01	4.39e-01
Inflammasomes	17	3.81e-01	-1.23e-01	6.05e-01
Transcriptional regulation of pluripotent stem cells	15	4.11e-01	1.23e-01	6.27e-01
VxPx cargo-targeting to cilium	19	3.55e-01	1.23e-01	5.79e-01
Cyclin D associated events in G1	45	1.56e-01	-1.22e-01	3.60e-01
G1 Phase	45	1.56e-01	-1.22e-01	3.60e-01
Degradation of the extracellular matrix	62	9.65e-02	1.22e-01	2.69e-01
Thrombin signalling through proteinase activated receptors (PARs)	20	3.48e-01	-1.21e-01	5.70e-01
Interleukin-12 family signaling	41	1.79e-01	1.21e-01	3.86e-01
Activation of NMDA receptors and postsynaptic events	55	1.22e-01	1.21e-01	3.15e-01
Phase I - Functionalization of compounds	48	1.51e-01	1.20e-01	3.55e-01
TNFR2 non-canonical NF-kB pathway	77	6.98e-02	-1.20e-01	2.19e-01
Regulation of beta-cell development	20	3.55e-01	-1.19e-01	5.79e-01
Cell recruitment (pro-inflammatory response)	18	3.82e-01	-1.19e-01	6.05e-01
Purinergic signaling in leishmaniasis infection	18	3.82e-01	-1.19e-01	6.05e-01
RHO GTPases Activate WASPs and WAVEs	31	2.53e-01	-1.19e-01	4.80e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.92e-01	1.18e-01	4.04e-01
Telomere Maintenance	70	8.97e-02	-1.17e-01	2.57e-01
Lysosome Vesicle Biogenesis	29	2.74e-01	-1.17e-01	4.98e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.90e-01	1.17e-01	6.10e-01
Neurexins and neuroligins	34	2.38e-01	1.17e-01	4.61e-01
DAP12 signaling	20	3.65e-01	1.17e-01	5.90e-01
The NLRP3 inflammasome	13	4.66e-01	-1.17e-01	6.69e-01
Diseases of mitotic cell cycle	37	2.19e-01	-1.17e-01	4.37e-01
Serotonin Neurotransmitter Release Cycle	11	5.03e-01	-1.17e-01	6.96e-01
Regulation of PTEN stability and activity	66	1.02e-01	-1.17e-01	2.79e-01
Signaling by TGFB family members	104	4.07e-02	1.16e-01	1.57e-01
RHOQ GTPase cycle	56	1.33e-01	1.16e-01	3.26e-01
Regulation of PTEN gene transcription	59	1.24e-01	-1.16e-01	3.17e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	5.26e-01	-1.16e-01	7.20e-01
CRMPs in Sema3A signaling	14	4.53e-01	1.16e-01	6.66e-01
TGF-beta receptor signaling activates SMADs	43	1.90e-01	1.16e-01	4.02e-01
MAP2K and MAPK activation	34	2.45e-01	1.15e-01	4.68e-01
Pre-NOTCH Expression and Processing	52	1.51e-01	1.15e-01	3.55e-01
Heme biosynthesis	12	4.90e-01	-1.15e-01	6.92e-01
Base Excision Repair	50	1.60e-01	-1.15e-01	3.62e-01
Signaling by KIT in disease	18	3.99e-01	1.15e-01	6.15e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	18	3.99e-01	1.15e-01	6.15e-01
O-linked glycosylation	68	1.04e-01	1.14e-01	2.83e-01
Antigen processing-Cross presentation	78	8.32e-02	-1.14e-01	2.47e-01
Glutamate Neurotransmitter Release Cycle	14	4.62e-01	1.14e-01	6.69e-01
Interleukin-37 signaling	14	4.63e-01	1.13e-01	6.69e-01
WNT5A-dependent internalization of FZD4	14	4.63e-01	-1.13e-01	6.69e-01
ER to Golgi Anterograde Transport	116	3.61e-02	1.13e-01	1.46e-01
tRNA modification in the nucleus and cytosol	43	2.01e-01	-1.13e-01	4.15e-01
HIV Life Cycle	140	2.15e-02	-1.13e-01	1.01e-01
Regulation of PLK1 Activity at G2/M Transition	86	7.17e-02	1.13e-01	2.24e-01
Calnexin/calreticulin cycle	26	3.23e-01	1.12e-01	5.42e-01
Synthesis of bile acids and bile salts	20	3.86e-01	-1.12e-01	6.08e-01
Cyclin A/B1/B2 associated events during G2/M transition	23	3.55e-01	1.11e-01	5.79e-01
Intra-Golgi traffic	39	2.32e-01	1.11e-01	4.55e-01
Activation of Matrix Metalloproteinases	12	5.07e-01	-1.11e-01	7.00e-01
SUMOylation of SUMOylation proteins	33	2.72e-01	1.11e-01	4.96e-01
Dual incision in TC-NER	64	1.27e-01	-1.10e-01	3.21e-01
Synthesis of PC	23	3.60e-01	-1.10e-01	5.84e-01
Regulated Necrosis	42	2.19e-01	-1.10e-01	4.37e-01
Diseases of glycosylation	107	5.08e-02	1.10e-01	1.78e-01
Phase II - Conjugation of compounds	64	1.30e-01	-1.09e-01	3.25e-01
Signaling by NTRKs	111	4.70e-02	1.09e-01	1.69e-01
UCH proteinases	83	8.64e-02	-1.09e-01	2.52e-01
Antiviral mechanism by IFN-stimulated genes	71	1.14e-01	1.09e-01	2.98e-01
Ca-dependent events	28	3.20e-01	1.09e-01	5.39e-01
Translesion synthesis by POLK	17	4.39e-01	-1.08e-01	6.53e-01
CLEC7A (Dectin-1) signaling	90	7.62e-02	-1.08e-01	2.34e-01
NOD1/2 Signaling Pathway	27	3.31e-01	1.08e-01	5.48e-01
GRB2 events in ERBB2 signaling	14	4.84e-01	-1.08e-01	6.87e-01
Hyaluronan uptake and degradation	10	5.56e-01	1.08e-01	7.44e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	22	3.84e-01	1.07e-01	6.06e-01
Trafficking of AMPA receptors	22	3.84e-01	1.07e-01	6.06e-01
ISG15 antiviral mechanism	66	1.33e-01	1.07e-01	3.26e-01
Signal Transduction	1760	6.86e-13	1.07e-01	1.17e-10
RHOH GTPase cycle	30	3.13e-01	1.06e-01	5.35e-01
Platelet degranulation	94	7.51e-02	1.06e-01	2.31e-01
Cytochrome c-mediated apoptotic response	12	5.26e-01	-1.06e-01	7.20e-01
Regulation of insulin secretion	49	2.01e-01	1.06e-01	4.15e-01
Sema3A PAK dependent Axon repulsion	16	4.65e-01	-1.06e-01	6.69e-01
NGF-stimulated transcription	34	2.90e-01	1.05e-01	5.16e-01
PI3K events in ERBB2 signaling	14	4.98e-01	-1.05e-01	6.93e-01
Diseases of signal transduction by growth factor receptors and second messengers	370	6.73e-04	1.04e-01	8.85e-03
Neddylation	210	1.02e-02	-1.03e-01	5.72e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	4.37e-01	-1.03e-01	6.49e-01
Oxidative Stress Induced Senescence	69	1.40e-01	-1.03e-01	3.37e-01
Cell-cell junction organization	32	3.14e-01	-1.03e-01	5.36e-01
Transcriptional regulation by RUNX2	106	6.79e-02	-1.03e-01	2.14e-01
Deactivation of the beta-catenin transactivating complex	38	2.74e-01	-1.03e-01	4.98e-01
Meiotic synapsis	31	3.23e-01	1.03e-01	5.42e-01
Erythropoietin activates RAS	12	5.40e-01	1.02e-01	7.30e-01
SUMOylation	157	2.80e-02	1.02e-01	1.22e-01
DNA Replication Pre-Initiation	103	7.48e-02	-1.02e-01	2.31e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	4.20e-01	1.02e-01	6.36e-01
Signaling by NODAL	13	5.26e-01	-1.02e-01	7.20e-01
Integration of energy metabolism	74	1.32e-01	1.01e-01	3.25e-01
PCP/CE pathway	85	1.07e-01	-1.01e-01	2.88e-01
Peroxisomal protein import	52	2.09e-01	-1.01e-01	4.25e-01
MHC class II antigen presentation	81	1.18e-01	1.01e-01	3.06e-01
Processive synthesis on the lagging strand	14	5.15e-01	1.00e-01	7.09e-01
Protein folding	78	1.28e-01	-9.98e-02	3.22e-01
Plasma lipoprotein assembly, remodeling, and clearance	52	2.16e-01	9.92e-02	4.34e-01
Ca2+ pathway	51	2.21e-01	9.92e-02	4.39e-01
PTEN Regulation	136	4.69e-02	-9.89e-02	1.69e-01
Chromosome Maintenance	95	9.79e-02	-9.84e-02	2.72e-01
Paracetamol ADME	17	4.83e-01	-9.83e-02	6.87e-01
Metabolic disorders of biological oxidation enzymes	19	4.59e-01	-9.81e-02	6.69e-01
Regulation of TP53 Activity through Methylation	17	4.84e-01	-9.81e-02	6.87e-01
Response to elevated platelet cytosolic Ca2+	98	9.65e-02	9.73e-02	2.69e-01
Nuclear Envelope (NE) Reassembly	65	1.75e-01	9.73e-02	3.82e-01
NOTCH1 Intracellular Domain Regulates Transcription	46	2.55e-01	-9.71e-02	4.82e-01
MicroRNA (miRNA) biogenesis	24	4.11e-01	-9.70e-02	6.27e-01
COPI-mediated anterograde transport	72	1.55e-01	9.70e-02	3.59e-01
Interleukin-2 family signaling	27	3.84e-01	9.68e-02	6.06e-01
Killing mechanisms	10	5.97e-01	-9.66e-02	7.70e-01
WNT5:FZD7-mediated leishmania damping	10	5.97e-01	-9.66e-02	7.70e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	37	3.10e-01	9.66e-02	5.34e-01
Signaling by RAS mutants	37	3.10e-01	9.66e-02	5.34e-01
Signaling by moderate kinase activity BRAF mutants	37	3.10e-01	9.66e-02	5.34e-01
Signaling downstream of RAS mutants	37	3.10e-01	9.66e-02	5.34e-01
Chaperonin-mediated protein folding	72	1.58e-01	-9.63e-02	3.61e-01
Mitotic Prophase	84	1.29e-01	9.61e-02	3.23e-01
G beta:gamma signalling through PI3Kgamma	17	4.94e-01	-9.58e-02	6.93e-01
Long-term potentiation	14	5.36e-01	9.57e-02	7.27e-01
G0 and Early G1	26	4.00e-01	9.53e-02	6.15e-01
Plasma lipoprotein remodeling	18	4.84e-01	9.53e-02	6.87e-01
The role of Nef in HIV-1 replication and disease pathogenesis	20	4.61e-01	-9.53e-02	6.69e-01
Cytosolic iron-sulfur cluster assembly	13	5.53e-01	-9.49e-02	7.42e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	4.21e-01	-9.49e-02	6.36e-01
activated TAK1 mediates p38 MAPK activation	18	4.87e-01	-9.47e-02	6.89e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	4.67e-01	-9.40e-02	6.70e-01
DNA strand elongation	31	3.66e-01	9.40e-02	5.90e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	24	4.27e-01	-9.37e-02	6.41e-01
Transferrin endocytosis and recycling	25	4.18e-01	9.36e-02	6.34e-01
Autophagy	118	7.98e-02	-9.35e-02	2.40e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	5.06e-01	-9.31e-02	7.00e-01
PPARA activates gene expression	101	1.08e-01	9.27e-02	2.89e-01
Josephin domain DUBs	11	5.95e-01	-9.26e-02	7.69e-01
TRP channels	10	6.13e-01	9.25e-02	7.82e-01
Phase 0 - rapid depolarisation	13	5.64e-01	-9.24e-02	7.48e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	5.51e-01	-9.22e-02	7.40e-01
C-type lectin receptors (CLRs)	108	9.90e-02	-9.21e-02	2.75e-01
HSF1 activation	25	4.26e-01	-9.20e-02	6.41e-01
Interleukin-6 family signaling	20	4.78e-01	9.18e-02	6.83e-01
Regulation of Complement cascade	20	4.79e-01	-9.16e-02	6.83e-01
Disorders of Developmental Biology	12	5.84e-01	-9.14e-02	7.58e-01
Disorders of Nervous System Development	12	5.84e-01	-9.14e-02	7.58e-01
Loss of function of MECP2 in Rett syndrome	12	5.84e-01	-9.14e-02	7.58e-01
Pervasive developmental disorders	12	5.84e-01	-9.14e-02	7.58e-01
SUMO E3 ligases SUMOylate target proteins	151	5.35e-02	9.13e-02	1.83e-01
DAP12 interactions	22	4.59e-01	9.12e-02	6.69e-01
TP53 Regulates Metabolic Genes	84	1.51e-01	-9.08e-02	3.55e-01
Transcriptional Regulation by MECP2	44	2.98e-01	9.07e-02	5.25e-01
Fcgamma receptor (FCGR) dependent phagocytosis	71	1.88e-01	9.06e-02	3.98e-01
ERBB2 Regulates Cell Motility	13	5.74e-01	-9.01e-02	7.54e-01
DNA Replication	128	7.94e-02	-9.00e-02	2.40e-01
MAPK targets/ Nuclear events mediated by MAP kinases	30	3.94e-01	-8.99e-02	6.11e-01
Purine catabolism	15	5.47e-01	-8.97e-02	7.36e-01
Constitutive Signaling by Overexpressed ERBB2	11	6.07e-01	8.96e-02	7.77e-01
FOXO-mediated transcription of cell cycle genes	16	5.36e-01	8.95e-02	7.27e-01
Nuclear signaling by ERBB4	25	4.40e-01	-8.92e-02	6.53e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	4.61e-01	-8.89e-02	6.69e-01
Receptor-type tyrosine-protein phosphatases	10	6.27e-01	8.88e-02	7.84e-01
Negative regulation of FGFR1 signaling	24	4.52e-01	-8.88e-02	6.65e-01
FCGR3A-mediated phagocytosis	48	2.91e-01	8.81e-02	5.16e-01
Leishmania phagocytosis	48	2.91e-01	8.81e-02	5.16e-01
Parasite infection	48	2.91e-01	8.81e-02	5.16e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	40	3.40e-01	8.72e-02	5.59e-01
Metabolism of lipids	555	5.14e-04	8.71e-02	6.89e-03
Recruitment of NuMA to mitotic centrosomes	79	1.82e-01	8.70e-02	3.89e-01
Cell-Cell communication	83	1.71e-01	8.70e-02	3.76e-01
Platelet activation, signaling and aggregation	185	4.23e-02	8.68e-02	1.59e-01
Suppression of phagosomal maturation	11	6.20e-01	-8.64e-02	7.83e-01
Methylation	11	6.21e-01	-8.62e-02	7.83e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	29	4.22e-01	8.61e-02	6.36e-01
Signaling by TGF-beta Receptor Complex	87	1.66e-01	8.61e-02	3.69e-01
Asparagine N-linked glycosylation	248	2.03e-02	8.60e-02	9.74e-02
RIPK1-mediated regulated necrosis	25	4.57e-01	-8.60e-02	6.68e-01
Regulation of necroptotic cell death	25	4.57e-01	-8.60e-02	6.68e-01
Fc epsilon receptor (FCERI) signaling	116	1.11e-01	-8.59e-02	2.93e-01
RNA Polymerase II Transcription	974	8.40e-06	-8.59e-02	1.98e-04
Cellular Senescence	132	8.96e-02	-8.58e-02	2.57e-01
Constitutive Signaling by EGFRvIII	15	5.66e-01	8.57e-02	7.48e-01
Signaling by EGFRvIII in Cancer	15	5.66e-01	8.57e-02	7.48e-01
Signaling by GPCR	286	1.32e-02	8.56e-02	7.10e-02
EPHB-mediated forward signaling	32	4.03e-01	8.55e-02	6.17e-01
CD209 (DC-SIGN) signaling	18	5.30e-01	-8.55e-02	7.23e-01
Pre-NOTCH Transcription and Translation	39	3.58e-01	8.51e-02	5.81e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	5.69e-01	8.50e-02	7.50e-01
Interleukin-1 signaling	102	1.41e-01	-8.44e-02	3.40e-01
Signal regulatory protein family interactions	10	6.44e-01	-8.43e-02	7.98e-01
p75 NTR receptor-mediated signalling	79	1.96e-01	8.43e-02	4.11e-01
Regulation of MECP2 expression and activity	29	4.33e-01	8.41e-02	6.47e-01
Signaling by FGFR	70	2.26e-01	-8.37e-02	4.45e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	22	4.98e-01	8.36e-02	6.93e-01
Transcriptional Regulation by E2F6	34	4.00e-01	8.35e-02	6.15e-01
Positive epigenetic regulation of rRNA expression	53	2.94e-01	-8.34e-02	5.20e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	5.64e-01	-8.33e-02	7.48e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	63	2.53e-01	-8.33e-02	4.80e-01
EGFR downregulation	27	4.54e-01	-8.32e-02	6.67e-01
Activation of ATR in response to replication stress	37	3.83e-01	8.30e-02	6.06e-01
Golgi Associated Vesicle Biogenesis	51	3.07e-01	8.27e-02	5.32e-01
Centrosome maturation	80	2.02e-01	8.27e-02	4.15e-01
Recruitment of mitotic centrosome proteins and complexes	80	2.02e-01	8.27e-02	4.15e-01
HDR through MMEJ (alt-NHEJ)	12	6.20e-01	-8.26e-02	7.83e-01
Interleukin-4 and Interleukin-13 signaling	73	2.23e-01	8.25e-02	4.41e-01
Endogenous sterols	17	5.56e-01	8.25e-02	7.44e-01
IRAK1 recruits IKK complex	10	6.52e-01	8.24e-02	8.03e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	6.52e-01	8.24e-02	8.03e-01
GPER1 signaling	32	4.21e-01	8.22e-02	6.36e-01
Death Receptor Signalling	118	1.24e-01	8.21e-02	3.17e-01
Signaling by NTRK1 (TRKA)	98	1.61e-01	8.21e-02	3.63e-01
Signaling by EGFR in Cancer	22	5.06e-01	-8.20e-02	7.00e-01
mRNA decay by 3’ to 5’ exoribonuclease	15	5.83e-01	-8.19e-02	7.58e-01
Regulation of lipid metabolism by PPARalpha	103	1.52e-01	8.18e-02	3.56e-01
Resolution of Abasic Sites (AP sites)	37	3.94e-01	-8.11e-02	6.11e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	6.00e-01	8.09e-02	7.72e-01
Processing of Capped Intronless Pre-mRNA	28	4.60e-01	-8.08e-02	6.69e-01
Generic Transcription Pathway	856	8.40e-05	-8.04e-02	1.42e-03
S Phase	157	8.35e-02	-8.03e-02	2.47e-01
SHC-mediated cascade:FGFR2	14	6.03e-01	8.03e-02	7.75e-01
Impaired BRCA2 binding to RAD51	35	4.15e-01	7.97e-02	6.32e-01
Biotin transport and metabolism	11	6.47e-01	7.97e-02	8.01e-01
GPCR downstream signalling	257	2.87e-02	7.96e-02	1.24e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	97	1.77e-01	-7.94e-02	3.82e-01
Toll Like Receptor 2 (TLR2) Cascade	97	1.77e-01	-7.94e-02	3.82e-01
Toll Like Receptor TLR1:TLR2 Cascade	97	1.77e-01	-7.94e-02	3.82e-01
Toll Like Receptor TLR6:TLR2 Cascade	97	1.77e-01	-7.94e-02	3.82e-01
Removal of the Flap Intermediate	13	6.21e-01	7.92e-02	7.83e-01
Leading Strand Synthesis	13	6.21e-01	-7.92e-02	7.83e-01
Polymerase switching	13	6.21e-01	-7.92e-02	7.83e-01
Negative regulation of the PI3K/AKT network	81	2.19e-01	7.91e-02	4.37e-01
Transport of small molecules	462	3.95e-03	7.89e-02	3.12e-02
Circadian Clock	63	2.80e-01	7.88e-02	5.05e-01
RAB geranylgeranylation	51	3.31e-01	-7.88e-02	5.48e-01
ROS and RNS production in phagocytes	21	5.32e-01	-7.87e-02	7.25e-01
Selective autophagy	54	3.19e-01	-7.85e-02	5.39e-01
Ovarian tumor domain proteases	33	4.36e-01	7.84e-02	6.49e-01
Detoxification of Reactive Oxygen Species	28	4.82e-01	-7.69e-02	6.86e-01
Negative regulators of DDX58/IFIH1 signaling	29	4.75e-01	-7.67e-02	6.80e-01
Glycerophospholipid biosynthesis	92	2.06e-01	-7.65e-02	4.18e-01
COPII-mediated vesicle transport	59	3.10e-01	7.64e-02	5.34e-01
Gene expression (Transcription)	1096	3.10e-05	-7.61e-02	6.42e-04
Deadenylation-dependent mRNA decay	51	3.48e-01	-7.61e-02	5.70e-01
RHOBTB2 GTPase cycle	23	5.29e-01	7.58e-02	7.23e-01
Homologous DNA Pairing and Strand Exchange	43	3.90e-01	7.58e-02	6.10e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	44	3.85e-01	-7.57e-02	6.07e-01
Host Interactions of HIV factors	115	1.62e-01	-7.56e-02	3.65e-01
Synthesis of substrates in N-glycan biosythesis	52	3.46e-01	-7.56e-02	5.69e-01
Hedgehog ‘on’ state	75	2.59e-01	-7.55e-02	4.84e-01
Downregulation of ERBB2 signaling	27	4.98e-01	-7.54e-02	6.93e-01
SHC-mediated cascade:FGFR3	11	6.66e-01	7.52e-02	8.09e-01
SHC-mediated cascade:FGFR4	11	6.66e-01	7.52e-02	8.09e-01
Interleukin-12 signaling	35	4.43e-01	7.50e-02	6.55e-01
Triglyceride catabolism	13	6.41e-01	7.48e-02	7.96e-01
Activation of kainate receptors upon glutamate binding	21	5.53e-01	-7.47e-02	7.42e-01
Metabolism of nitric oxide: NOS3 activation and regulation	12	6.55e-01	-7.44e-02	8.04e-01
RUNX2 regulates bone development	26	5.13e-01	7.41e-02	7.07e-01
Defective pyroptosis	20	5.66e-01	7.41e-02	7.49e-01
Translation of Structural Proteins	28	4.99e-01	-7.39e-02	6.93e-01
Rap1 signalling	12	6.59e-01	7.37e-02	8.04e-01
Nuclear events mediated by NFE2L2	74	2.74e-01	-7.36e-02	4.98e-01
Blood group systems biosynthesis	10	6.87e-01	7.35e-02	8.22e-01
Lewis blood group biosynthesis	10	6.87e-01	7.35e-02	8.22e-01
RHOBTB1 GTPase cycle	23	5.43e-01	-7.33e-02	7.33e-01
Membrane Trafficking	525	4.52e-03	7.31e-02	3.38e-02
Signaling by NOTCH3	42	4.18e-01	-7.24e-02	6.34e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	17	6.06e-01	-7.23e-02	7.76e-01
Constitutive Signaling by Aberrant PI3K in Cancer	47	3.94e-01	7.19e-02	6.11e-01
trans-Golgi Network Vesicle Budding	65	3.17e-01	7.18e-02	5.38e-01
N-Glycan antennae elongation	13	6.54e-01	-7.17e-02	8.04e-01
Beta-oxidation of very long chain fatty acids	11	6.81e-01	-7.15e-02	8.18e-01
Glycogen breakdown (glycogenolysis)	12	6.69e-01	7.14e-02	8.12e-01
Protein-protein interactions at synapses	52	3.74e-01	7.14e-02	5.99e-01
Signaling by FGFR4	32	4.85e-01	-7.13e-02	6.88e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	22	5.63e-01	-7.12e-02	7.48e-01
Aggrephagy	20	5.83e-01	-7.10e-02	7.58e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	71	3.03e-01	-7.07e-02	5.29e-01
Negative regulation of MAPK pathway	42	4.28e-01	7.07e-02	6.41e-01
Processing of SMDT1	14	6.48e-01	-7.05e-02	8.01e-01
ERK/MAPK targets	21	5.76e-01	-7.04e-02	7.56e-01
Vesicle-mediated transport	549	5.33e-03	7.02e-02	3.63e-02
Neurotransmitter receptors and postsynaptic signal transmission	105	2.16e-01	7.01e-02	4.34e-01
E2F mediated regulation of DNA replication	21	5.78e-01	-7.01e-02	7.57e-01
Late SARS-CoV-2 Infection Events	55	3.69e-01	7.00e-02	5.94e-01
Regulation of actin dynamics for phagocytic cup formation	50	3.92e-01	7.00e-02	6.11e-01
PCNA-Dependent Long Patch Base Excision Repair	20	5.89e-01	-6.99e-02	7.62e-01
Pexophagy	10	7.03e-01	-6.97e-02	8.29e-01
GABA receptor activation	28	5.25e-01	-6.95e-02	7.20e-01
Post NMDA receptor activation events	46	4.15e-01	6.95e-02	6.32e-01
MyD88-independent TLR4 cascade	99	2.34e-01	-6.94e-02	4.57e-01
TRIF(TICAM1)-mediated TLR4 signaling	99	2.34e-01	-6.94e-02	4.57e-01
SUMOylation of ubiquitinylation proteins	38	4.60e-01	6.93e-02	6.69e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	11	6.91e-01	6.92e-02	8.23e-01
Signaling by FGFR3	33	4.94e-01	-6.89e-02	6.93e-01
Clathrin-mediated endocytosis	117	1.99e-01	6.89e-02	4.15e-01
Metalloprotease DUBs	17	6.26e-01	-6.82e-02	7.84e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	23	5.72e-01	-6.81e-02	7.52e-01
Gene Silencing by RNA	72	3.18e-01	6.81e-02	5.38e-01
Diseases associated with glycosylation precursor biosynthesis	15	6.49e-01	6.80e-02	8.01e-01
NOTCH4 Intracellular Domain Regulates Transcription	18	6.18e-01	-6.79e-02	7.83e-01
Interleukin-10 signaling	18	6.20e-01	6.76e-02	7.83e-01
Retrograde transport at the Trans-Golgi-Network	47	4.23e-01	6.76e-02	6.37e-01
Transcriptional Regulation by TP53	339	3.44e-02	-6.73e-02	1.41e-01
Notch-HLH transcription pathway	27	5.46e-01	-6.72e-02	7.36e-01
Developmental Biology	661	3.62e-03	-6.72e-02	2.94e-02
Toll Like Receptor 3 (TLR3) Cascade	96	2.57e-01	-6.70e-02	4.84e-01
TNFR1-induced NFkappaB signaling pathway	25	5.63e-01	6.69e-02	7.48e-01
MyD88 dependent cascade initiated on endosome	92	2.68e-01	-6.69e-02	4.92e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	92	2.68e-01	-6.69e-02	4.92e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	91	2.72e-01	-6.68e-02	4.96e-01
MAP kinase activation	61	3.67e-01	-6.68e-02	5.92e-01
Reproduction	60	3.74e-01	6.64e-02	5.99e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	26	5.59e-01	-6.62e-02	7.47e-01
Mitotic Metaphase and Anaphase	216	9.50e-02	6.62e-02	2.67e-01
GRB2 events in EGFR signaling	10	7.17e-01	-6.62e-02	8.38e-01
Norepinephrine Neurotransmitter Release Cycle	10	7.17e-01	-6.61e-02	8.38e-01
Toll Like Receptor 4 (TLR4) Cascade	120	2.13e-01	-6.60e-02	4.31e-01
Anchoring of the basal body to the plasma membrane	96	2.66e-01	6.58e-02	4.89e-01
Transport of Mature Transcript to Cytoplasm	79	3.13e-01	-6.58e-02	5.35e-01
Insulin processing	22	5.94e-01	6.57e-02	7.69e-01
Regulation of HSF1-mediated heat shock response	76	3.25e-01	6.54e-02	5.44e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	13	6.84e-01	-6.53e-02	8.20e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	13	6.84e-01	-6.53e-02	8.20e-01
FCERI mediated MAPK activation	26	5.66e-01	-6.51e-02	7.48e-01
Mitotic Anaphase	215	1.01e-01	6.51e-02	2.79e-01
Diseases of metabolism	181	1.33e-01	6.49e-02	3.26e-01
Sensory Perception	194	1.21e-01	-6.48e-02	3.13e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	6.26e-01	-6.47e-02	7.84e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	6.26e-01	-6.47e-02	7.84e-01
VEGFA-VEGFR2 Pathway	81	3.17e-01	6.45e-02	5.38e-01
Leishmania infection	133	2.01e-01	6.43e-02	4.15e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	67	3.65e-01	-6.41e-02	5.90e-01
Formation of apoptosome	10	7.26e-01	-6.40e-02	8.42e-01
Regulation of the apoptosome activity	10	7.26e-01	-6.40e-02	8.42e-01
Prolactin receptor signaling	12	7.01e-01	-6.40e-02	8.29e-01
Gap junction trafficking and regulation	15	6.70e-01	6.36e-02	8.12e-01
Mitochondrial tRNA aminoacylation	21	6.14e-01	6.36e-02	7.83e-01
DNA Double Strand Break Response	45	4.62e-01	-6.35e-02	6.69e-01
Vitamin B5 (pantothenate) metabolism	16	6.62e-01	6.31e-02	8.07e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	51	4.37e-01	6.30e-02	6.49e-01
Signaling by the B Cell Receptor (BCR)	93	2.95e-01	-6.30e-02	5.20e-01
Nonhomologous End-Joining (NHEJ)	35	5.21e-01	6.28e-02	7.15e-01
Separation of Sister Chromatids	163	1.69e-01	6.27e-02	3.72e-01
Cytosolic sensors of pathogen-associated DNA	59	4.07e-01	-6.25e-02	6.22e-01
PRC2 methylates histones and DNA	20	6.29e-01	6.25e-02	7.85e-01
Activation of RAC1	11	7.22e-01	-6.21e-02	8.41e-01
SUMOylation of intracellular receptors	22	6.16e-01	-6.18e-02	7.83e-01
Complement cascade	22	6.17e-01	-6.17e-02	7.83e-01
Purine salvage	12	7.12e-01	-6.16e-02	8.35e-01
KEAP1-NFE2L2 pathway	94	3.03e-01	-6.15e-02	5.29e-01
SHC1 events in EGFR signaling	11	7.24e-01	-6.14e-02	8.42e-01
Chemokine receptors bind chemokines	13	7.02e-01	-6.14e-02	8.29e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	4.97e-01	6.13e-02	6.93e-01
Diseases of DNA Double-Strand Break Repair	41	4.97e-01	6.13e-02	6.93e-01
DARPP-32 events	22	6.20e-01	-6.11e-02	7.83e-01
Termination of translesion DNA synthesis	31	5.57e-01	-6.10e-02	7.44e-01
Scavenging by Class A Receptors	14	6.93e-01	6.10e-02	8.24e-01
Rab regulation of trafficking	114	2.64e-01	-6.07e-02	4.88e-01
Assembly of the ORC complex at the origin of replication	16	6.75e-01	-6.06e-02	8.13e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	7.17e-01	6.05e-02	8.38e-01
Meiosis	53	4.47e-01	6.05e-02	6.61e-01
Extension of Telomeres	49	4.65e-01	-6.04e-02	6.69e-01
DNA Damage Bypass	46	4.79e-01	6.03e-02	6.84e-01
Transcriptional regulation by RUNX1	155	1.97e-01	-6.02e-02	4.12e-01
Ephrin signaling	18	6.58e-01	-6.02e-02	8.04e-01
Caspase activation via Death Receptors in the presence of ligand	12	7.18e-01	-6.02e-02	8.38e-01
G1/S Transition	126	2.46e-01	-6.00e-02	4.70e-01
Cell Cycle, Mitotic	478	2.62e-02	5.99e-02	1.16e-01
Nucleotide salvage	21	6.35e-01	-5.98e-02	7.91e-01
Regulation of FOXO transcriptional activity by acetylation	10	7.44e-01	5.97e-02	8.52e-01
Deubiquitination	225	1.26e-01	5.95e-02	3.18e-01
Sema4D in semaphorin signaling	22	6.30e-01	5.94e-02	7.86e-01
Epigenetic regulation of gene expression	94	3.20e-01	-5.94e-02	5.40e-01
Arachidonic acid metabolism	29	5.80e-01	5.94e-02	7.58e-01
Post-translational protein modification	1102	1.15e-03	5.92e-02	1.41e-02
M Phase	339	6.35e-02	5.90e-02	2.06e-01
RAF activation	32	5.64e-01	5.89e-02	7.48e-01
AKT phosphorylates targets in the cytosol	14	7.04e-01	-5.86e-02	8.29e-01
EPH-ephrin mediated repulsion of cells	42	5.13e-01	-5.85e-02	7.06e-01
Meiotic recombination	29	5.87e-01	5.84e-02	7.61e-01
RET signaling	30	5.84e-01	5.78e-02	7.58e-01
Extra-nuclear estrogen signaling	57	4.51e-01	5.78e-02	6.65e-01
Chromatin modifying enzymes	203	1.58e-01	5.77e-02	3.61e-01
Chromatin organization	203	1.58e-01	5.77e-02	3.61e-01
Macroautophagy	106	3.06e-01	-5.77e-02	5.30e-01
Ion transport by P-type ATPases	28	5.98e-01	5.77e-02	7.70e-01
Presynaptic phase of homologous DNA pairing and strand exchange	40	5.30e-01	5.74e-02	7.23e-01
Translesion Synthesis by POLH	18	6.74e-01	-5.73e-02	8.12e-01
NOTCH2 intracellular domain regulates transcription	10	7.55e-01	5.70e-02	8.57e-01
Ion homeostasis	29	5.96e-01	-5.69e-02	7.70e-01
FOXO-mediated transcription of cell death genes	15	7.04e-01	5.67e-02	8.29e-01
Formation of the beta-catenin:TCF transactivating complex	38	5.47e-01	5.65e-02	7.36e-01
Branched-chain amino acid catabolism	21	6.55e-01	-5.64e-02	8.04e-01
Semaphorin interactions	56	4.66e-01	5.64e-02	6.69e-01
HDR through Homologous Recombination (HRR)	66	4.29e-01	5.64e-02	6.41e-01
Regulation of TP53 Degradation	34	5.71e-01	-5.62e-02	7.51e-01
Regulation of TP53 Expression and Degradation	34	5.71e-01	-5.62e-02	7.51e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	7.06e-01	5.62e-02	8.31e-01
Axon guidance	416	5.13e-02	-5.61e-02	1.79e-01
Neutrophil degranulation	334	8.00e-02	5.61e-02	2.40e-01
Transcriptional regulation of granulopoiesis	30	6.00e-01	5.53e-02	7.72e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	7.33e-01	5.47e-02	8.45e-01
Glucagon signaling in metabolic regulation	22	6.58e-01	5.46e-02	8.04e-01
Dopamine Neurotransmitter Release Cycle	14	7.25e-01	5.44e-02	8.42e-01
Cellular responses to stress	636	2.16e-02	-5.40e-02	1.01e-01
ADORA2B mediated anti-inflammatory cytokines production	44	5.36e-01	5.39e-02	7.27e-01
Peroxisomal lipid metabolism	25	6.41e-01	-5.39e-02	7.96e-01
Signaling by VEGF	89	3.81e-01	5.38e-02	6.05e-01
Interleukin-7 signaling	18	6.93e-01	-5.38e-02	8.24e-01
mTORC1-mediated signalling	23	6.56e-01	-5.37e-02	8.04e-01
Keratan sulfate biosynthesis	21	6.71e-01	5.37e-02	8.12e-01
Platelet calcium homeostasis	18	6.94e-01	5.36e-02	8.24e-01
Cellular responses to stimuli	639	2.22e-02	-5.36e-02	1.04e-01
B-WICH complex positively regulates rRNA expression	38	5.68e-01	-5.36e-02	7.49e-01
Synthesis of IP3 and IP4 in the cytosol	19	6.87e-01	5.35e-02	8.22e-01
MyD88 cascade initiated on plasma membrane	87	3.90e-01	-5.34e-02	6.10e-01
Toll Like Receptor 10 (TLR10) Cascade	87	3.90e-01	-5.34e-02	6.10e-01
Toll Like Receptor 5 (TLR5) Cascade	87	3.90e-01	-5.34e-02	6.10e-01
Cellular response to heat stress	93	3.74e-01	5.34e-02	5.99e-01
Diseases associated with O-glycosylation of proteins	40	5.60e-01	5.33e-02	7.47e-01
RA biosynthesis pathway	12	7.49e-01	5.33e-02	8.53e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	4.99e-01	-5.32e-02	6.93e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	4.99e-01	-5.32e-02	6.93e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	4.99e-01	-5.32e-02	6.93e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	4.99e-01	-5.32e-02	6.93e-01
Signaling by NOTCH1 in Cancer	54	4.99e-01	-5.32e-02	6.93e-01
ZBP1(DAI) mediated induction of type I IFNs	19	6.89e-01	-5.30e-02	8.23e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	16	7.14e-01	5.29e-02	8.37e-01
Interleukin-17 signaling	64	4.65e-01	-5.28e-02	6.69e-01
ABC-family proteins mediated transport	87	3.96e-01	-5.27e-02	6.12e-01
The canonical retinoid cycle in rods (twilight vision)	13	7.44e-01	5.22e-02	8.52e-01
MTOR signalling	39	5.77e-01	-5.17e-02	7.56e-01
Iron uptake and transport	48	5.38e-01	-5.14e-02	7.28e-01
Transmission across Chemical Synapses	141	2.94e-01	5.13e-02	5.20e-01
Cell Cycle Checkpoints	246	1.71e-01	5.09e-02	3.76e-01
CTLA4 inhibitory signaling	18	7.09e-01	5.08e-02	8.33e-01
Signaling by Receptor Tyrosine Kinases	392	8.88e-02	5.04e-02	2.56e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	6.45e-01	-5.04e-02	7.98e-01
Interleukin-1 family signaling	125	3.33e-01	-5.03e-02	5.49e-01
Signalling to ERKs	29	6.42e-01	4.99e-02	7.96e-01
Signaling by ERBB4	45	5.65e-01	-4.97e-02	7.48e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	74	4.61e-01	4.96e-02	6.69e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	4.07e-01	4.96e-02	6.22e-01
HDACs deacetylate histones	36	6.08e-01	-4.94e-02	7.77e-01
Cilium Assembly	180	2.55e-01	4.93e-02	4.82e-01
Interferon Signaling	134	3.27e-01	-4.92e-02	5.47e-01
TNFs bind their physiological receptors	14	7.52e-01	4.88e-02	8.55e-01
Bile acid and bile salt metabolism	24	6.79e-01	-4.88e-02	8.17e-01
TAK1-dependent IKK and NF-kappa-B activation	38	6.04e-01	-4.87e-02	7.75e-01
Homology Directed Repair	100	4.03e-01	4.85e-02	6.17e-01
MAPK1/MAPK3 signaling	219	2.23e-01	4.80e-02	4.39e-01
Phospholipid metabolism	162	2.99e-01	4.74e-02	5.25e-01
Transcriptional regulation of white adipocyte differentiation	71	4.91e-01	-4.73e-02	6.92e-01
PI3K/AKT Signaling in Cancer	73	4.90e-01	4.68e-02	6.92e-01
RHO GTPases activate KTN1	11	7.90e-01	-4.63e-02	8.83e-01
Negative regulation of MET activity	19	7.28e-01	-4.62e-02	8.42e-01
Cytosolic sulfonation of small molecules	17	7.43e-01	-4.59e-02	8.52e-01
Peptide hormone metabolism	49	5.81e-01	4.56e-02	7.58e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	29	6.72e-01	4.55e-02	8.12e-01
Insulin receptor recycling	20	7.26e-01	4.52e-02	8.42e-01
Activation of GABAB receptors	24	7.02e-01	-4.52e-02	8.29e-01
GABA B receptor activation	24	7.02e-01	-4.52e-02	8.29e-01
Signaling by Nuclear Receptors	194	2.81e-01	4.50e-02	5.06e-01
Striated Muscle Contraction	19	7.38e-01	-4.44e-02	8.47e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	7.60e-01	4.41e-02	8.62e-01
Toll Like Receptor 9 (TLR9) Cascade	96	4.57e-01	-4.40e-02	6.68e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	7.84e-01	4.38e-02	8.81e-01
Pre-NOTCH Processing in Golgi	14	7.77e-01	4.37e-02	8.77e-01
SUMOylation of transcription cofactors	42	6.25e-01	-4.36e-02	7.84e-01
Nervous system development	432	1.25e-01	-4.34e-02	3.17e-01
Platelet sensitization by LDL	15	7.75e-01	4.26e-02	8.76e-01
RUNX2 regulates osteoblast differentiation	21	7.36e-01	-4.26e-02	8.46e-01
Surfactant metabolism	13	7.92e-01	-4.22e-02	8.83e-01
Mitotic G1 phase and G1/S transition	143	3.86e-01	-4.21e-02	6.08e-01
Signaling by Hedgehog	116	4.35e-01	4.20e-02	6.49e-01
HCMV Infection	84	5.09e-01	4.17e-02	7.02e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	15	7.80e-01	4.17e-02	8.78e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	6.66e-01	-4.16e-02	8.09e-01
ESR-mediated signaling	143	3.95e-01	4.13e-02	6.11e-01
Early Phase of HIV Life Cycle	10	8.21e-01	4.12e-02	9.00e-01
SUMOylation of chromatin organization proteins	53	6.05e-01	4.11e-02	7.76e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	6.23e-01	4.07e-02	7.83e-01
TP53 Regulates Transcription of Cell Cycle Genes	46	6.33e-01	4.07e-02	7.89e-01
Glycogen metabolism	22	7.42e-01	-4.05e-02	8.52e-01
G2/M Checkpoints	131	4.29e-01	-4.02e-02	6.41e-01
CD28 co-stimulation	28	7.15e-01	3.99e-02	8.38e-01
HATs acetylate histones	82	5.35e-01	3.97e-02	7.27e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	8.04e-01	3.97e-02	8.92e-01
Viral Messenger RNA Synthesis	43	6.59e-01	-3.89e-02	8.04e-01
DNA Repair	282	2.67e-01	-3.86e-02	4.90e-01
Class B/2 (Secretin family receptors)	36	6.91e-01	-3.83e-02	8.23e-01
Cell Cycle	594	1.15e-01	3.83e-02	3.00e-01
Beta-catenin independent WNT signaling	129	4.54e-01	-3.83e-02	6.67e-01
Signaling by ERBB2 TMD/JMD mutants	20	7.70e-01	-3.78e-02	8.70e-01
Generation of second messenger molecules	12	8.22e-01	-3.75e-02	9.00e-01
HCMV Late Events	58	6.22e-01	3.74e-02	7.83e-01
O-glycosylation of TSR domain-containing proteins	25	7.46e-01	3.74e-02	8.53e-01
Mismatch Repair	14	8.10e-01	3.72e-02	8.94e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	8.10e-01	3.71e-02	8.94e-01
Intrinsic Pathway for Apoptosis	48	6.59e-01	-3.69e-02	8.04e-01
Immune System	1317	2.94e-02	3.67e-02	1.26e-01
Class A/1 (Rhodopsin-like receptors)	79	5.76e-01	3.64e-02	7.56e-01
Nuclear events stimulated by ALK signaling in cancer	17	7.95e-01	3.64e-02	8.84e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	20	7.80e-01	-3.62e-02	8.78e-01
Apoptotic factor-mediated response	17	7.97e-01	-3.61e-02	8.85e-01
Transcriptional activation of mitochondrial biogenesis	51	6.57e-01	-3.60e-02	8.04e-01
Incretin synthesis, secretion, and inactivation	10	8.44e-01	-3.59e-02	9.12e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	10	8.44e-01	-3.59e-02	9.12e-01
Transcriptional regulation by small RNAs	53	6.53e-01	3.57e-02	8.04e-01
Metabolism of cofactors	16	8.09e-01	-3.49e-02	8.94e-01
Response of Mtb to phagocytosis	20	7.88e-01	3.48e-02	8.83e-01
Antigen processing: Ubiquitination & Proteasome degradation	269	3.30e-01	-3.46e-02	5.48e-01
Signaling by Non-Receptor Tyrosine Kinases	51	6.72e-01	-3.43e-02	8.12e-01
Signaling by PTK6	51	6.72e-01	-3.43e-02	8.12e-01
Nicotinamide salvaging	16	8.13e-01	3.41e-02	8.96e-01
Signaling by SCF-KIT	33	7.35e-01	3.40e-02	8.46e-01
COPI-independent Golgi-to-ER retrograde traffic	30	7.47e-01	3.40e-02	8.53e-01
Smooth Muscle Contraction	33	7.36e-01	3.39e-02	8.46e-01
Association of TriC/CCT with target proteins during biosynthesis	37	7.22e-01	3.38e-02	8.42e-01
Platelet homeostasis	55	6.65e-01	-3.37e-02	8.09e-01
Regulation of localization of FOXO transcription factors	11	8.47e-01	3.36e-02	9.12e-01
GAB1 signalosome	14	8.31e-01	-3.30e-02	9.03e-01
Regulation of TP53 Activity	148	4.90e-01	-3.29e-02	6.92e-01
PIP3 activates AKT signaling	231	3.94e-01	-3.27e-02	6.11e-01
Disease	1313	5.27e-02	3.27e-02	1.82e-01
Infectious disease	707	1.44e-01	-3.27e-02	3.44e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	8.39e-01	-3.25e-02	9.09e-01
Signaling by EGFR	46	7.04e-01	3.24e-02	8.29e-01
RAF/MAP kinase cascade	214	4.16e-01	3.24e-02	6.32e-01
Visual phototransduction	57	6.73e-01	3.24e-02	8.12e-01
Potential therapeutics for SARS	79	6.23e-01	-3.21e-02	7.83e-01
Cargo trafficking to the periciliary membrane	48	7.01e-01	3.21e-02	8.29e-01
G-protein beta:gamma signalling	22	7.95e-01	-3.20e-02	8.84e-01
SUMOylation of DNA damage response and repair proteins	73	6.37e-01	3.19e-02	7.93e-01
Signaling by ERBB2 ECD mutants	16	8.26e-01	3.18e-02	9.01e-01
Ub-specific processing proteases	158	4.94e-01	3.16e-02	6.93e-01
Interleukin-15 signaling	12	8.50e-01	3.16e-02	9.12e-01
Caspase activation via extrinsic apoptotic signalling pathway	20	8.11e-01	3.09e-02	8.94e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	8.53e-01	-3.09e-02	9.13e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	7.82e-01	-3.08e-02	8.79e-01
Metabolism of nucleotides	81	6.33e-01	3.07e-02	7.89e-01
Fanconi Anemia Pathway	35	7.53e-01	-3.07e-02	8.56e-01
Drug ADME	41	7.36e-01	3.04e-02	8.46e-01
Trafficking of GluR2-containing AMPA receptors	13	8.50e-01	-3.04e-02	9.12e-01
Diseases of DNA repair	51	7.09e-01	3.02e-02	8.33e-01
rRNA modification in the nucleus and cytosol	59	6.90e-01	-3.01e-02	8.23e-01
Signaling by NOTCH1	68	6.73e-01	-2.97e-02	8.12e-01
Programmed Cell Death	174	5.03e-01	-2.95e-02	6.96e-01
Signaling by ERBB2	47	7.27e-01	-2.95e-02	8.42e-01
G2/M DNA damage checkpoint	61	6.91e-01	2.94e-02	8.23e-01
Activation of BAD and translocation to mitochondria	15	8.46e-01	2.89e-02	9.12e-01
Amino acids regulate mTORC1	48	7.30e-01	2.89e-02	8.43e-01
BBSome-mediated cargo-targeting to cilium	22	8.15e-01	-2.88e-02	8.97e-01
Transport of vitamins, nucleosides, and related molecules	24	8.08e-01	2.87e-02	8.94e-01
Diseases associated with the TLR signaling cascade	21	8.21e-01	-2.86e-02	9.00e-01
Diseases of Immune System	21	8.21e-01	-2.86e-02	9.00e-01
SARS-CoV-2-host interactions	156	5.42e-01	-2.84e-02	7.32e-01
Post-chaperonin tubulin folding pathway	16	8.45e-01	-2.83e-02	9.12e-01
Signaling by NOTCH	166	5.34e-01	-2.81e-02	7.27e-01
FLT3 Signaling	32	7.85e-01	2.79e-02	8.81e-01
Infection with Mycobacterium tuberculosis	22	8.21e-01	-2.78e-02	9.00e-01
TNFR1-induced proapoptotic signaling	12	8.70e-01	-2.74e-02	9.24e-01
Uptake and actions of bacterial toxins	22	8.25e-01	2.72e-02	9.01e-01
Biological oxidations	116	6.20e-01	-2.67e-02	7.83e-01
RUNX3 regulates NOTCH signaling	14	8.63e-01	2.66e-02	9.19e-01
Diseases associated with N-glycosylation of proteins	20	8.40e-01	-2.62e-02	9.09e-01
SARS-CoV-2 Infection	235	4.92e-01	2.61e-02	6.92e-01
MAPK family signaling cascades	256	4.76e-01	2.60e-02	6.81e-01
Costimulation by the CD28 family	44	7.66e-01	2.60e-02	8.67e-01
Estrogen-dependent gene expression	88	6.77e-01	2.57e-02	8.14e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	8.55e-01	2.56e-02	9.13e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	8.55e-01	2.56e-02	9.13e-01
G alpha (i) signalling events	124	6.24e-01	-2.55e-02	7.84e-01
Innate Immune System	692	2.61e-01	2.54e-02	4.87e-01
Neuronal System	201	5.38e-01	2.53e-02	7.28e-01
Cell junction organization	55	7.50e-01	2.49e-02	8.53e-01
Signaling by ALK	21	8.44e-01	2.49e-02	9.12e-01
Other interleukin signaling	14	8.72e-01	-2.48e-02	9.27e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	8.32e-01	-2.46e-02	9.03e-01
TRAF6 mediated NF-kB activation	19	8.54e-01	2.44e-02	9.13e-01
Recognition of DNA damage by PCNA-containing replication complex	29	8.21e-01	-2.43e-02	9.00e-01
Downregulation of TGF-beta receptor signaling	26	8.31e-01	-2.42e-02	9.03e-01
Stimuli-sensing channels	53	7.61e-01	-2.42e-02	8.63e-01
Carboxyterminal post-translational modifications of tubulin	28	8.28e-01	2.37e-02	9.02e-01
HDR through Single Strand Annealing (SSA)	37	8.04e-01	2.36e-02	8.92e-01
Adherens junctions interactions	19	8.59e-01	2.35e-02	9.15e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	8.80e-01	2.32e-02	9.31e-01
SUMOylation of RNA binding proteins	45	7.90e-01	-2.30e-02	8.83e-01
Prefoldin mediated transfer of substrate to CCT/TriC	24	8.47e-01	-2.28e-02	9.12e-01
Opioid Signalling	66	7.50e-01	2.27e-02	8.53e-01
Signaling by ERBB2 in Cancer	24	8.49e-01	2.25e-02	9.12e-01
E3 ubiquitin ligases ubiquitinate target proteins	43	8.05e-01	-2.17e-02	8.92e-01
Defective Intrinsic Pathway for Apoptosis	23	8.57e-01	-2.17e-02	9.14e-01
Regulated proteolysis of p75NTR	10	9.06e-01	2.16e-02	9.51e-01
Pyrimidine salvage	10	9.09e-01	-2.09e-02	9.51e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	11	9.06e-01	2.05e-02	9.51e-01
TNF signaling	43	8.27e-01	-1.92e-02	9.02e-01
Sialic acid metabolism	23	8.73e-01	-1.92e-02	9.27e-01
HSF1-dependent transactivation	31	8.55e-01	-1.90e-02	9.13e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	44	8.28e-01	1.89e-02	9.02e-01
Amyloid fiber formation	42	8.34e-01	-1.87e-02	9.05e-01
Organelle biogenesis and maintenance	268	6.10e-01	-1.82e-02	7.79e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	49	8.26e-01	1.81e-02	9.01e-01
DNA Double-Strand Break Repair	130	7.31e-01	1.75e-02	8.44e-01
Toll-like Receptor Cascades	134	7.28e-01	-1.74e-02	8.42e-01
Defective B3GALTL causes PpS	24	8.83e-01	1.74e-02	9.31e-01
Intraflagellar transport	37	8.58e-01	1.71e-02	9.14e-01
RAB GEFs exchange GTP for GDP on RABs	84	7.89e-01	-1.69e-02	8.83e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	34	8.66e-01	-1.68e-02	9.21e-01
Ion channel transport	98	7.82e-01	1.62e-02	8.79e-01
G alpha (q) signalling events	95	7.92e-01	-1.57e-02	8.83e-01
Oncogene Induced Senescence	32	8.79e-01	1.55e-02	9.31e-01
G2/M Transition	177	7.24e-01	-1.54e-02	8.42e-01
RHOBTB GTPase Cycle	35	8.75e-01	1.54e-02	9.28e-01
SHC1 events in ERBB4 signaling	12	9.27e-01	-1.53e-02	9.59e-01
RAS processing	19	9.09e-01	1.52e-02	9.51e-01
Glutamate and glutamine metabolism	11	9.31e-01	-1.51e-02	9.60e-01
tRNA processing in the nucleus	56	8.49e-01	1.48e-02	9.12e-01
Nuclear Events (kinase and transcription factor activation)	55	8.51e-01	1.46e-02	9.12e-01
Signaling by WNT	240	6.98e-01	-1.46e-02	8.28e-01
Hedgehog ‘off’ state	89	8.12e-01	-1.46e-02	8.95e-01
Cardiac conduction	57	8.51e-01	-1.44e-02	9.12e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	9.10e-01	1.43e-02	9.51e-01
Neurodegenerative Diseases	21	9.10e-01	1.43e-02	9.51e-01
Diseases of carbohydrate metabolism	29	8.95e-01	-1.42e-02	9.42e-01
Metabolism of steroid hormones	18	9.21e-01	-1.35e-02	9.59e-01
Transcription of E2F targets under negative control by DREAM complex	19	9.19e-01	1.34e-02	9.59e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	9.27e-01	1.33e-02	9.59e-01
Disorders of transmembrane transporters	132	7.95e-01	1.31e-02	8.84e-01
TCF dependent signaling in response to WNT	160	7.77e-01	1.30e-02	8.77e-01
Uptake and function of anthrax toxins	10	9.44e-01	1.28e-02	9.66e-01
Apoptosis	153	7.87e-01	-1.27e-02	8.82e-01
Post-translational modification: synthesis of GPI-anchored proteins	48	8.81e-01	-1.25e-02	9.31e-01
Class I peroxisomal membrane protein import	18	9.27e-01	1.25e-02	9.59e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	9.41e-01	-1.22e-02	9.65e-01
GPCR ligand binding	117	8.20e-01	1.22e-02	9.00e-01
Unblocking of NMDA receptors, glutamate binding and activation	14	9.39e-01	1.18e-02	9.65e-01
Metabolism of non-coding RNA	52	8.83e-01	-1.18e-02	9.31e-01
snRNP Assembly	52	8.83e-01	-1.18e-02	9.31e-01
Signaling by FGFR in disease	52	8.86e-01	1.15e-02	9.34e-01
SARS-CoV-2 modulates autophagy	10	9.50e-01	-1.14e-02	9.70e-01
Binding and Uptake of Ligands by Scavenger Receptors	26	9.22e-01	1.10e-02	9.59e-01
Cytochrome P450 - arranged by substrate type	27	9.22e-01	1.09e-02	9.59e-01
Vasopressin regulates renal water homeostasis via Aquaporins	27	9.23e-01	-1.08e-02	9.59e-01
Signaling by Retinoic Acid	30	9.20e-01	1.06e-02	9.59e-01
Signaling by Interleukins	329	7.49e-01	1.03e-02	8.53e-01
DCC mediated attractive signaling	12	9.53e-01	-9.81e-03	9.70e-01
Deposition of new CENPA-containing nucleosomes at the centromere	32	9.24e-01	9.78e-03	9.59e-01
Nucleosome assembly	32	9.24e-01	9.78e-03	9.59e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	19	9.42e-01	9.68e-03	9.65e-01
Processing of DNA double-strand break ends	61	8.97e-01	9.59e-03	9.43e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	30	9.28e-01	9.48e-03	9.59e-01
Attenuation phase	22	9.41e-01	9.10e-03	9.65e-01
Nuclear Receptor transcription pathway	34	9.28e-01	-8.99e-03	9.59e-01
VLDLR internalisation and degradation	15	9.53e-01	8.88e-03	9.70e-01
Citric acid cycle (TCA cycle)	22	9.43e-01	8.85e-03	9.65e-01
Cargo recognition for clathrin-mediated endocytosis	83	8.89e-01	-8.85e-03	9.37e-01
SARS-CoV Infections	305	7.92e-01	8.82e-03	8.83e-01
TP53 Regulates Transcription of Cell Death Genes	34	9.31e-01	8.64e-03	9.60e-01
Activation of BH3-only proteins	27	9.40e-01	8.35e-03	9.65e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	9.30e-01	8.33e-03	9.60e-01
Peptide ligand-binding receptors	42	9.27e-01	8.15e-03	9.59e-01
IL-6-type cytokine receptor ligand interactions	14	9.58e-01	8.12e-03	9.72e-01
Regulation of NF-kappa B signaling	17	9.54e-01	-8.10e-03	9.70e-01
Signaling by Activin	13	9.60e-01	8.03e-03	9.74e-01
EPH-Ephrin signaling	80	9.01e-01	8.03e-03	9.47e-01
Lagging Strand Synthesis	19	9.53e-01	7.82e-03	9.70e-01
Adaptive Immune System	533	7.65e-01	7.64e-03	8.66e-01
Signaling by NOTCH2	28	9.46e-01	-7.40e-03	9.66e-01
Aquaporin-mediated transport	30	9.44e-01	-7.38e-03	9.66e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	57	9.27e-01	-6.98e-03	9.59e-01
Signaling by FGFR1	41	9.39e-01	6.93e-03	9.65e-01
Mitotic G2-G2/M phases	179	8.80e-01	-6.56e-03	9.31e-01
Netrin-1 signaling	36	9.49e-01	-6.13e-03	9.69e-01
Cytokine Signaling in Immune system	492	8.26e-01	-5.85e-03	9.01e-01
Listeria monocytogenes entry into host cells	18	9.70e-01	5.09e-03	9.82e-01
Metabolism of proteins	1508	7.49e-01	-5.08e-03	8.53e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	9.73e-01	-4.93e-03	9.84e-01
FOXO-mediated transcription	54	9.54e-01	-4.50e-03	9.70e-01
Metabolism	1593	7.95e-01	-4.04e-03	8.84e-01
Fatty acid metabolism	128	9.41e-01	-3.79e-03	9.65e-01
Regulation of TNFR1 signaling	34	9.70e-01	3.69e-03	9.82e-01
Class I MHC mediated antigen processing & presentation	315	9.13e-01	-3.60e-03	9.54e-01
KSRP (KHSRP) binds and destabilizes mRNA	16	9.81e-01	3.48e-03	9.89e-01
Muscle contraction	104	9.55e-01	3.18e-03	9.70e-01
Intracellular signaling by second messengers	262	9.35e-01	-2.93e-03	9.63e-01
Regulation of IFNA/IFNB signaling	11	9.87e-01	-2.87e-03	9.92e-01
Protein ubiquitination	63	9.69e-01	2.83e-03	9.82e-01
Gap junction trafficking	13	9.86e-01	-2.79e-03	9.92e-01
Diseases of programmed cell death	48	9.78e-01	2.35e-03	9.88e-01
Signaling by ERBB2 KD Mutants	23	9.85e-01	2.26e-03	9.92e-01
DNA Damage/Telomere Stress Induced Senescence	37	9.84e-01	-1.90e-03	9.92e-01
Regulation of TP53 Activity through Phosphorylation	89	9.79e-01	1.60e-03	9.89e-01
SARS-CoV-1 Infection	45	9.85e-01	1.59e-03	9.92e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	25	9.91e-01	1.30e-03	9.95e-01
Processing of Intronless Pre-mRNAs	19	9.94e-01	1.01e-03	9.98e-01
RIP-mediated NFkB activation via ZBP1	16	9.95e-01	9.47e-04	9.98e-01
Voltage gated Potassium channels	11	9.97e-01	7.63e-04	9.98e-01
Mitochondrial calcium ion transport	20	9.97e-01	-5.05e-04	9.98e-01
Deadenylation of mRNA	21	9.97e-01	-4.93e-04	9.98e-01
Nicotinate metabolism	25	1.00e+00	-3.59e-05	1.00e+00

---

Detailed Gene set reports

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

	1366
set	tRNA processing in the mitochondrion
setSize	18
pANOVA	2.56e-07
s.dist	-0.701
p.adjustANOVA	8.76e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND6	-6005
MT-ND2	-5987
MT-ND4	-5978
MT-ND1	-5971
MT-CYB	-5962
MT-ATP8	-5958
MT-ATP6	-5894
MT-CO1	-5824
MT-CO3	-5645
HSD17B10	-5546
MT-ND5	-5464
MT-ND3	-4901
ELAC2	-2846
MT-ND4L	-2630
PRORP	-1452
TRMT10C	-1393
TRNT1	-1379
MT-CO2	3727

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND6	-6005
MT-ND2	-5987
MT-ND4	-5978
MT-ND1	-5971
MT-CYB	-5962
MT-ATP8	-5958
MT-ATP6	-5894
MT-CO1	-5824
MT-CO3	-5645
HSD17B10	-5546
MT-ND5	-5464
MT-ND3	-4901
ELAC2	-2846
MT-ND4L	-2630
PRORP	-1452
TRMT10C	-1393
TRNT1	-1379
MT-CO2	3727

---

Cholesterol biosynthesis

Cholesterol biosynthesis

	168
set	Cholesterol biosynthesis
setSize	26
pANOVA	1.02e-09
s.dist	0.692
p.adjustANOVA	4.97e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HMGCR	6265
LSS	6244
SQLE	6233
DHCR24	6229
HMGCS1	6164
CYP51A1	6076
IDI1	6007
NSDHL	5988
LBR	5976
FDPS	5929
SC5D	5919
MVD	5889
SREBF2	5879
HSD17B7	5862
ACAT2	5688
MSMO1	5648
FDFT1	4557
MVK	4426
TM7SF2	3914
PMVK	3782

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HMGCR	6265
LSS	6244
SQLE	6233
DHCR24	6229
HMGCS1	6164
CYP51A1	6076
IDI1	6007
NSDHL	5988
LBR	5976
FDPS	5929
SC5D	5919
MVD	5889
SREBF2	5879
HSD17B7	5862
ACAT2	5688
MSMO1	5648
FDFT1	4557
MVK	4426
TM7SF2	3914
PMVK	3782
DHCR7	3729
SREBF1	3235
EBP	-347
ARV1	-823
GGPS1	-2279
PLPP6	-2486

---

rRNA processing in the mitochondrion

rRNA processing in the mitochondrion

	1360
set	rRNA processing in the mitochondrion
setSize	21
pANOVA	8.74e-07
s.dist	-0.62
p.adjustANOVA	2.54e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MTERF4	-5997
MT-ND2	-5987
MT-ND4	-5978
MT-ND1	-5971
MT-CYB	-5962
MT-ATP8	-5958
MT-ATP6	-5894
MT-CO1	-5824
MT-CO3	-5645
HSD17B10	-5546
MT-ND5	-5464
MT-ND3	-4901
ELAC2	-2846
MT-ND4L	-2630
MRM2	-2026
TFB1M	-1577
PRORP	-1452
TRMT10C	-1393
MRM1	-41
MRM3	266

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MTERF4	-5997
MT-ND2	-5987
MT-ND4	-5978
MT-ND1	-5971
MT-CYB	-5962
MT-ATP8	-5958
MT-ATP6	-5894
MT-CO1	-5824
MT-CO3	-5645
HSD17B10	-5546
MT-ND5	-5464
MT-ND3	-4901
ELAC2	-2846
MT-ND4L	-2630
MRM2	-2026
TFB1M	-1577
PRORP	-1452
TRMT10C	-1393
MRM1	-41
MRM3	266
MT-CO2	3727

---

MET activates PTK2 signaling

MET activates PTK2 signaling

	611
set	MET activates PTK2 signaling
setSize	12
pANOVA	0.000611
s.dist	0.571
p.adjustANOVA	0.00812

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB1	6188
LAMA5	5762
LAMB2	4913
ITGA2	4663
PTK2	4333
ITGA3	4068
LAMC1	4028
LAMC2	3528
LAMB1	3200
LAMB3	3026
SRC	571
MET	-615

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB1	6188
LAMA5	5762
LAMB2	4913
ITGA2	4663
PTK2	4333
ITGA3	4068
LAMC1	4028
LAMC2	3528
LAMB1	3200
LAMB3	3026
SRC	571
MET	-615

---

ALK mutants bind TKIs

ALK mutants bind TKIs

	9
set	ALK mutants bind TKIs
setSize	10
pANOVA	0.0021
s.dist	0.562
p.adjustANOVA	0.0207

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BIRC6	6182
CLTC	6133
FN1	6049
PPM1B	4960
PRKAR1A	4931
STRN	4727
EIF2AK3	4721
HIP1	4546
EML4	-1728
NPM1	-4720

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BIRC6	6182
CLTC	6133
FN1	6049
PPM1B	4960
PRKAR1A	4931
STRN	4727
EIF2AK3	4721
HIP1	4546
EML4	-1728
NPM1	-4720

---

Laminin interactions

Laminin interactions

	587
set	Laminin interactions
setSize	18
pANOVA	3.71e-05
s.dist	0.562
p.adjustANOVA	0.000715

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGAV	6242
ITGB1	6188
HSPG2	5946
LAMA5	5762
ITGA7	5646
LAMB2	4913
ITGA2	4663
ITGA3	4068
LAMC1	4028
NID1	3709
COL18A1	3647
ITGA1	3532
LAMC2	3528
LAMB1	3200
LAMB3	3026
ITGB4	1902
ITGA6	312
NID2	-5917

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGAV	6242
ITGB1	6188
HSPG2	5946
LAMA5	5762
ITGA7	5646
LAMB2	4913
ITGA2	4663
ITGA3	4068
LAMC1	4028
NID1	3709
COL18A1	3647
ITGA1	3532
LAMC2	3528
LAMB1	3200
LAMB3	3026
ITGB4	1902
ITGA6	312
NID2	-5917

---

Apoptosis induced DNA fragmentation

Apoptosis induced DNA fragmentation

	70
set	Apoptosis induced DNA fragmentation
setSize	10
pANOVA	0.00504
s.dist	0.512
p.adjustANOVA	0.0356

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H1-2	6223
KPNB1	5121
HMGB2	4819
H1-3	4523
H1-4	4202
H1-0	3395
DFFA	2346
KPNA1	1250
CASP3	592
DFFB	292

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H1-2	6223
KPNB1	5121
HMGB2	4819
H1-3	4523
H1-4	4202
H1-0	3395
DFFA	2346
KPNA1	1250
CASP3	592
DFFB	292

---

Membrane binding and targetting of GAG proteins

Membrane binding and targetting of GAG proteins

	623
set	Membrane binding and targetting of GAG proteins
setSize	14
pANOVA	0.0012
s.dist	-0.5
p.adjustANOVA	0.0143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5753
TSG101	-5714
VPS28	-5424
RPS27A	-5344
UBAP1	-5098
UBB	-4930
MVB12A	-4676
NMT2	-3113
VPS37B	-2145
MVB12B	-2090
VPS37D	-2032
VPS37C	-607
UBC	1127
VPS37A	4688

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5753
TSG101	-5714
VPS28	-5424
RPS27A	-5344
UBAP1	-5098
UBB	-4930
MVB12A	-4676
NMT2	-3113
VPS37B	-2145
MVB12B	-2090
VPS37D	-2032
VPS37C	-607
UBC	1127
VPS37A	4688

---

Synthesis And Processing Of GAG, GAGPOL Polyproteins

Synthesis And Processing Of GAG, GAGPOL Polyproteins

	1182
set	Synthesis And Processing Of GAG, GAGPOL Polyproteins
setSize	14
pANOVA	0.0012
s.dist	-0.5
p.adjustANOVA	0.0143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5753
TSG101	-5714
VPS28	-5424
RPS27A	-5344
UBAP1	-5098
UBB	-4930
MVB12A	-4676
NMT2	-3113
VPS37B	-2145
MVB12B	-2090
VPS37D	-2032
VPS37C	-607
UBC	1127
VPS37A	4688

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5753
TSG101	-5714
VPS28	-5424
RPS27A	-5344
UBAP1	-5098
UBB	-4930
MVB12A	-4676
NMT2	-3113
VPS37B	-2145
MVB12B	-2090
VPS37D	-2032
VPS37C	-607
UBC	1127
VPS37A	4688

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	385
set	Formation of a pool of free 40S subunits
setSize	79
pANOVA	4.97e-14
s.dist	-0.49
p.adjustANOVA	1.72e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
EIF3F	-5822
RPL23A	-5817
RPS28	-5799
EIF3K	-5794
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
RPS27A	-5344

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
EIF3F	-5822.0
RPL23A	-5817.0
RPS28	-5799.0
EIF3K	-5794.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
EIF3H	-5175.0
RPL35A	-5148.0
RPL14	-5046.0
EIF3J	-5003.0
RPS5	-4988.0
RPS17	-4860.0
EIF3I	-4701.0
EIF3E	-4661.0
RPS19	-4560.0
RPS11	-4469.0
EIF3L	-4434.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
EIF3M	-3968.0
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
EIF3G	-3720.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
EIF3B	-2321.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
EIF3D	-226.0
RPL27A	228.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
EIF1AX	2870.0
RPS9	3205.0
RPL12	3366.0
EIF3C	3490.5
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF3A	6202.0

---

Peptide chain elongation

Peptide chain elongation

	794
set	Peptide chain elongation
setSize	67
pANOVA	4.04e-12
s.dist	-0.49
p.adjustANOVA	4.6e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
RPL23A	-5817
RPS28	-5799
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
RPS27A	-5344
RPL34	-5319
RPS8	-5264

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
RPS19	-4560.0
RPS11	-4469.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
EEF1A1	-2985.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
RPL27A	228.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
RPS9	3205.0
RPL12	3366.0
EEF2	3968.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0

---

Syndecan interactions

Syndecan interactions

	1181
set	Syndecan interactions
setSize	19
pANOVA	0.000268
s.dist	0.483
p.adjustANOVA	0.00395

Top enriched genes

Top 20 genes

GeneID	Gene Rank
THBS1	6274
ITGAV	6242
ITGB3	6215
ITGB5	6213
ITGB1	6188
SDC1	6165
ACTN1	6122
SDC2	4835
FGF2	4814
CASK	4730
ITGA2	4663
SDC3	2236
ITGB4	1902
TNC	895
ITGA6	312
TRAPPC4	-588
SDC4	-1091
PRKCA	-3602
TGFB1	-3726

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
THBS1	6274
ITGAV	6242
ITGB3	6215
ITGB5	6213
ITGB1	6188
SDC1	6165
ACTN1	6122
SDC2	4835
FGF2	4814
CASK	4730
ITGA2	4663
SDC3	2236
ITGB4	1902
TNC	895
ITGA6	312
TRAPPC4	-588
SDC4	-1091
PRKCA	-3602
TGFB1	-3726

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	346
set	Eukaryotic Translation Termination
setSize	71
pANOVA	3.87e-12
s.dist	-0.477
p.adjustANOVA	4.6e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
RPL23A	-5817
RPS28	-5799
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
TRMT112	-5408
RPS27A	-5344
RPL34	-5319

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
TRMT112	-5408.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
RPS19	-4560.0
RPS11	-4469.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
N6AMT1	-4017.0
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
GSPT2	-2233.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
RPL27A	228.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
APEH	1099.0
RPLP1	1114.0
RPL30	1658.0
ETF1	2208.0
RPS9	3205.0
RPL12	3366.0
GSPT1	3814.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	391
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	47
pANOVA	1.87e-08
s.dist	-0.474
p.adjustANOVA	7.52e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS24	-5953
RPS15	-5897
EIF2S2	-5891
EIF3F	-5822
RPS28	-5799
EIF3K	-5794
RPS26	-5788
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPS27A	-5344
RPS8	-5264
EIF3H	-5175
EIF3J	-5003
RPS5	-4988
RPS17	-4860
EIF3I	-4701
EIF3E	-4661
RPS19	-4560
RPS11	-4469

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS24	-5953.0
RPS15	-5897.0
EIF2S2	-5891.0
EIF3F	-5822.0
RPS28	-5799.0
EIF3K	-5794.0
RPS26	-5788.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPS27A	-5344.0
RPS8	-5264.0
EIF3H	-5175.0
EIF3J	-5003.0
RPS5	-4988.0
RPS17	-4860.0
EIF3I	-4701.0
EIF3E	-4661.0
RPS19	-4560.0
RPS11	-4469.0
EIF3L	-4434.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
EIF3M	-3968.0
EIF3G	-3720.0
RPS18	-3498.0
RPS12	-3380.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
EIF3B	-2321.0
RPS14	-1992.0
RPS2	-1741.0
RPS29	-1526.0
RPS10	-810.0
RPS21	-782.0
EIF3D	-226.0
EIF2S1	150.0
RPS3A	729.0
RPS16	922.0
EIF1AX	2870.0
RPS9	3205.0
EIF3C	3490.5
EIF2S3	3918.5
RPS7	4000.0
EIF3A	6202.0

---

Viral mRNA Translation

Viral mRNA Translation

	1323
set	Viral mRNA Translation
setSize	67
pANOVA	1.99e-11
s.dist	-0.474
p.adjustANOVA	1.3e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
RPL23A	-5817
RPS28	-5799
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
RPS27A	-5344
RPL34	-5319
RPS8	-5264

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
RPS19	-4560.0
RPS11	-4469.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
RPL27A	228.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
GRSF1	2246.0
RPS9	3205.0
RPL12	3366.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
DNAJC3	5352.0

---

Telomere C-strand synthesis initiation

Telomere C-strand synthesis initiation

	1234
set	Telomere C-strand synthesis initiation
setSize	13
pANOVA	0.00338
s.dist	-0.47
p.adjustANOVA	0.0282

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACD	-5901
TERF2	-5472
CTC1	-4949
TERF1	-4726
STN1	-4087
TERF2IP	-3541
TINF2	-3162
PRIM2	-3083
TEN1	-2887
POT1	-2620
POLA2	-289
PRIM1	100
POLA1	4854

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACD	-5901
TERF2	-5472
CTC1	-4949
TERF1	-4726
STN1	-4087
TERF2IP	-3541
TINF2	-3162
PRIM2	-3083
TEN1	-2887
POT1	-2620
POLA2	-289
PRIM1	100
POLA1	4854

---

Mitochondrial translation initiation

Mitochondrial translation initiation

	659
set	Mitochondrial translation initiation
setSize	88
pANOVA	2.75e-14
s.dist	-0.47
p.adjustANOVA	1.72e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977
MRPL14	-4917

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977
MRPL14	-4917
MRPS25	-4909
MRPS5	-4886
MRPL40	-4883
MRPL22	-4800
MRPL4	-4765
MRPL54	-4679
MRPS17	-4655
MRPS2	-4621
MRPL49	-4614
MRPL35	-4568
MRPS16	-4526
MRPS11	-4460
MRPL45	-4336
MRPL18	-4118
MRPL30	-3989
CHCHD1	-3967
MRPS35	-3962
MRPL1	-3856
MRPL57	-3839
MRPL39	-3788
ERAL1	-3721
MRPL28	-3705
MRPL37	-3521
MRPS26	-3275
MRPS30	-3259
MRPL52	-3221
MRPS18C	-3122
MRPL46	-3084
MRPL27	-3002
MRPL11	-2999
PTCD3	-2972
MTIF3	-2956
MRPS22	-2900
MRPL15	-2668
MRPS27	-2637
MRPS10	-2562
MRPS24	-2541
MRPS9	-2157
MRPL17	-2140
MTIF2	-2052
MRPL12	-1893
MRPL43	-1783
MRPL21	-1775
AURKAIP1	-1600
MRPL16	-1442
MRPS12	-1225
MTFMT	-1079
MRPS31	-1051
DAP3	-992
MRPL51	-837
MRPL36	-828
MRPL47	-221
MRPL10	-198
MRPS23	-190
MRPL3	-97
MRPL2	19
MRPL44	134
MRPL19	468
MRPL55	1194
MRPL20	1314
MRPL53	2111
MRPS14	2147
MRPS34	2358
MRPL23	2639
MRPS28	2674
MRPL9	4595
MRPL33	5054
MRPS6	5573

---

Mitochondrial translation termination

Mitochondrial translation termination

	660
set	Mitochondrial translation termination
setSize	88
pANOVA	5.02e-14
s.dist	-0.465
p.adjustANOVA	1.72e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRRF	-5250
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRRF	-5250
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977
MRPL14	-4917
MRPS25	-4909
MRPS5	-4886
MRPL40	-4883
MRPL22	-4800
MRPL4	-4765
MRPL54	-4679
MRPS17	-4655
MRPS2	-4621
MRPL49	-4614
MRPL35	-4568
MRPS16	-4526
MRPS11	-4460
MRPL45	-4336
MRPL18	-4118
MRPL30	-3989
CHCHD1	-3967
MRPS35	-3962
MRPL1	-3856
MRPL57	-3839
MRPL39	-3788
ERAL1	-3721
MRPL28	-3705
MRPL37	-3521
MRPS26	-3275
MRPS30	-3259
MRPL52	-3221
MRPS18C	-3122
MRPL46	-3084
MRPL27	-3002
MRPL11	-2999
PTCD3	-2972
MRPS22	-2900
MRPL15	-2668
MRPS27	-2637
MRPS10	-2562
MRPS24	-2541
MRPS9	-2157
MRPL17	-2140
MRPL12	-1893
MRPL43	-1783
MRPL21	-1775
AURKAIP1	-1600
MRPL16	-1442
MRPS12	-1225
MRPS31	-1051
MTRF1L	-1046
DAP3	-992
MRPL51	-837
MRPL36	-828
MRPL47	-221
MRPL10	-198
MRPS23	-190
MRPL3	-97
MRPL2	19
MRPL44	134
MRPL19	468
MRPL55	1194
MRPL20	1314
MRPL53	2111
MRPS14	2147
MRPS34	2358
MRPL23	2639
MRPS28	2674
GFM2	2790
MRPL9	4595
MRPL33	5054
MRPS6	5573

---

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Regulation of cholesterol biosynthesis by SREBP (SREBF)

	982
set	Regulation of cholesterol biosynthesis by SREBP (SREBF)
setSize	54
pANOVA	3.89e-09
s.dist	0.463
p.adjustANOVA	1.77e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HMGCR	6265
SCD	6255
LSS	6244
SQLE	6233
INSIG1	6198
HMGCS1	6164
SEC24D	6108
CYP51A1	6076
IDI1	6007
FDPS	5929
SC5D	5919
MVD	5889
SREBF2	5879
ACACA	5851
ELOVL6	5643
FASN	5556
SEC23A	5487
SEC24A	5278
MED1	5181
KPNB1	5121

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HMGCR	6265.0
SCD	6255.0
LSS	6244.0
SQLE	6233.0
INSIG1	6198.0
HMGCS1	6164.0
SEC24D	6108.0
CYP51A1	6076.0
IDI1	6007.0
FDPS	5929.0
SC5D	5919.0
MVD	5889.0
SREBF2	5879.0
ACACA	5851.0
ELOVL6	5643.0
FASN	5556.0
SEC23A	5487.0
SEC24A	5278.0
MED1	5181.0
KPNB1	5121.0
MBTPS2	5033.0
GPAM	4848.0
TBL1XR1	4666.0
NCOA2	4634.0
FDFT1	4557.0
INSIG2	4551.0
SP1	4531.0
HELZ2	4486.0
MVK	4426.0
TM7SF2	3914.0
PMVK	3782.0
DHCR7	3729.0
NCOA1	3480.0
CREBBP	3254.0
SREBF1	3235.0
SEC24C	3087.0
NFYB	2490.0
SEC24B	1859.0
RAN	1694.0
NCOA6	1610.0
SCAP	918.0
MTF1	889.0
MBTPS1	828.0
TBL1X	449.5
NFYA	-10.0
ACACB	-1102.0
GGPS1	-2279.0
RXRA	-2529.0
CARM1	-3430.0
TGS1	-3595.0
CHD9	-4625.0
SAR1B	-5183.0
SMARCD3	-5457.0
NFYC	-5826.0

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	344
set	Eukaryotic Translation Elongation
setSize	70
pANOVA	4.54e-11
s.dist	-0.455
p.adjustANOVA	2.82e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
RPL23A	-5817
RPS28	-5799
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
RPS27A	-5344
RPL34	-5319
RPS8	-5264

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
RPS19	-4560.0
RPS11	-4469.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
EEF1A1	-2985.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
EEF1D	-506.0
RPL27A	228.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
EEF1B2	2444.0
RPS9	3205.0
RPL12	3366.0
EEF2	3968.0
RPL10	3987.0
RPS7	4000.0
EEF1G	4387.0
RPL27	4941.0

---

Mitochondrial translation elongation

Mitochondrial translation elongation

	658
set	Mitochondrial translation elongation
setSize	88
pANOVA	1.93e-13
s.dist	-0.454
p.adjustANOVA	4.4e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977
MRPL14	-4917

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977
MRPL14	-4917
MRPS25	-4909
MRPS5	-4886
MRPL40	-4883
MRPL22	-4800
MRPL4	-4765
MRPL54	-4679
MRPS17	-4655
MRPS2	-4621
MRPL49	-4614
MRPL35	-4568
MRPS16	-4526
MRPS11	-4460
MRPL45	-4336
MRPL18	-4118
MRPL30	-3989
CHCHD1	-3967
MRPS35	-3962
MRPL1	-3856
MRPL57	-3839
MRPL39	-3788
ERAL1	-3721
MRPL28	-3705
MRPL37	-3521
MRPS26	-3275
MRPS30	-3259
MRPL52	-3221
MRPS18C	-3122
MRPL46	-3084
MRPL27	-3002
MRPL11	-2999
PTCD3	-2972
MRPS22	-2900
MRPL15	-2668
MRPS27	-2637
MRPS10	-2562
MRPS24	-2541
MRPS9	-2157
MRPL17	-2140
TUFM	-1941
MRPL12	-1893
MRPL43	-1783
MRPL21	-1775
AURKAIP1	-1600
MRPL16	-1442
MRPS12	-1225
MRPS31	-1051
DAP3	-992
MRPL51	-837
MRPL36	-828
MRPL47	-221
MRPL10	-198
MRPS23	-190
MRPL3	-97
MRPL2	19
MRPL44	134
MRPL19	468
GFM1	635
MRPL55	1194
MRPL20	1314
MRPL53	2111
MRPS14	2147
MRPS34	2358
MRPL23	2639
MRPS28	2674
TSFM	3679
MRPL9	4595
MRPL33	5054
MRPS6	5573

---

Activation of gene expression by SREBF (SREBP)

Activation of gene expression by SREBF (SREBP)

	44
set	Activation of gene expression by SREBF (SREBP)
setSize	41
pANOVA	5.14e-07
s.dist	0.453
p.adjustANOVA	1.6e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HMGCR	6265
SCD	6255
LSS	6244
SQLE	6233
HMGCS1	6164
CYP51A1	6076
IDI1	6007
FDPS	5929
SC5D	5919
MVD	5889
SREBF2	5879
ACACA	5851
ELOVL6	5643
FASN	5556
MED1	5181
GPAM	4848
TBL1XR1	4666
NCOA2	4634
FDFT1	4557
SP1	4531

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HMGCR	6265.0
SCD	6255.0
LSS	6244.0
SQLE	6233.0
HMGCS1	6164.0
CYP51A1	6076.0
IDI1	6007.0
FDPS	5929.0
SC5D	5919.0
MVD	5889.0
SREBF2	5879.0
ACACA	5851.0
ELOVL6	5643.0
FASN	5556.0
MED1	5181.0
GPAM	4848.0
TBL1XR1	4666.0
NCOA2	4634.0
FDFT1	4557.0
SP1	4531.0
HELZ2	4486.0
MVK	4426.0
TM7SF2	3914.0
PMVK	3782.0
DHCR7	3729.0
NCOA1	3480.0
CREBBP	3254.0
SREBF1	3235.0
NFYB	2490.0
NCOA6	1610.0
MTF1	889.0
TBL1X	449.5
NFYA	-10.0
ACACB	-1102.0
GGPS1	-2279.0
RXRA	-2529.0
CARM1	-3430.0
TGS1	-3595.0
CHD9	-4625.0
SMARCD3	-5457.0
NFYC	-5826.0

---

Cytosolic tRNA aminoacylation

Cytosolic tRNA aminoacylation

	220
set	Cytosolic tRNA aminoacylation
setSize	24
pANOVA	0.000128
s.dist	0.452
p.adjustANOVA	0.00206

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LARS1	6128
NARS1	6117
EPRS1	6033
IARS1	5921
GARS1	5813
AARS1	5788
WARS1	5672
TARS1	5651
MARS1	5283
CARS1	5136
SARS1	5048
VARS1	4677
DARS1	4106
PPA1	2766
HARS1	2729
FARSB	2340
YARS1	1683
RARS1	1448
QARS1	768
EEF1E1	0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LARS1	6128
NARS1	6117
EPRS1	6033
IARS1	5921
GARS1	5813
AARS1	5788
WARS1	5672
TARS1	5651
MARS1	5283
CARS1	5136
SARS1	5048
VARS1	4677
DARS1	4106
PPA1	2766
HARS1	2729
FARSB	2340
YARS1	1683
RARS1	1448
QARS1	768
EEF1E1	0
AIMP1	-168
FARSA	-3341
AIMP2	-4776
KARS1	-5181

---

Selenocysteine synthesis

Selenocysteine synthesis

	1064
set	Selenocysteine synthesis
setSize	71
pANOVA	5.83e-11
s.dist	-0.45
p.adjustANOVA	3.32e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
RPL23A	-5817
RPS28	-5799
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
RPS27A	-5344
RPL34	-5319
RPS8	-5264

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
RPS19	-4560.0
RPS11	-4469.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
EEFSEC	-3723.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
PSTK	-1323.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
RPL27A	228.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
SECISBP2	948.0
RPLP1	1114.0
RPL30	1658.0
SEPHS2	2373.0
RPS9	3205.0
RPL12	3366.0
SEPSECS	3846.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
SARS1	5048.0

---

Abortive elongation of HIV-1 transcript in the absence of Tat

Abortive elongation of HIV-1 transcript in the absence of Tat

	27
set	Abortive elongation of HIV-1 transcript in the absence of Tat
setSize	23
pANOVA	0.000218
s.dist	-0.445
p.adjustANOVA	0.00332

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2J	-5809
POLR2I	-5691
GTF2F2	-5685
POLR2E	-5628
POLR2C	-5357
NELFE	-4954
POLR2L	-4936
NELFA	-4597
POLR2D	-4355
GTF2F1	-4024
NELFCD	-3549
SUPT4H1	-3123
POLR2F	-2817
SUPT5H	-2128
NCBP1	-1814
POLR2B	-878
POLR2G	-559
POLR2H	-151
CTDP1	-130
NCBP2	356

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2J	-5809
POLR2I	-5691
GTF2F2	-5685
POLR2E	-5628
POLR2C	-5357
NELFE	-4954
POLR2L	-4936
NELFA	-4597
POLR2D	-4355
GTF2F1	-4024
NELFCD	-3549
SUPT4H1	-3123
POLR2F	-2817
SUPT5H	-2128
NCBP1	-1814
POLR2B	-878
POLR2G	-559
POLR2H	-151
CTDP1	-130
NCBP2	356
POLR2A	820
NELFB	1534
POLR2K	3669

---

Mitochondrial translation

Mitochondrial translation

	657
set	Mitochondrial translation
setSize	94
pANOVA	1.17e-13
s.dist	-0.443
p.adjustANOVA	3.2e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRRF	-5250
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GADD45GIP1	-5912
MRPS15	-5890
OXA1L	-5699
MRPS36	-5678
MRPL32	-5624
MRPS18A	-5617
MRPS21	-5554
MRPL41	-5551
MRPL58	-5501
MRPL50	-5449
MRPL38	-5416
MRPS33	-5384
MRPL34	-5342
MRPS18B	-5322
MRPS7	-5312
MRPL13	-5304
MRRF	-5250
MRPL48	-5239
MRPL42	-5172
MRPL24	-4977
MRPL14	-4917
MRPS25	-4909
MRPS5	-4886
MRPL40	-4883
MRPL22	-4800
MRPL4	-4765
MRPL54	-4679
MRPS17	-4655
MRPS2	-4621
MRPL49	-4614
MRPL35	-4568
MRPS16	-4526
MRPS11	-4460
MRPL45	-4336
MRPL18	-4118
MRPL30	-3989
CHCHD1	-3967
MRPS35	-3962
MRPL1	-3856
MRPL57	-3839
MRPL39	-3788
ERAL1	-3721
MRPL28	-3705
MRPL37	-3521
MRPS26	-3275
MRPS30	-3259
MRPL52	-3221
MRPS18C	-3122
MRPL46	-3084
MRPL27	-3002
MRPL11	-2999
PTCD3	-2972
MTIF3	-2956
MRPS22	-2900
MRPL15	-2668
MRPS27	-2637
MRPS10	-2562
MRPS24	-2541
MRPS9	-2157
MRPL17	-2140
MTIF2	-2052
TUFM	-1941
MRPL12	-1893
MRPL43	-1783
MRPL21	-1775
AURKAIP1	-1600
MRPL16	-1442
MRPS12	-1225
MTFMT	-1079
MRPS31	-1051
MTRF1L	-1046
DAP3	-992
MRPL51	-837
MRPL36	-828
MRPL47	-221
MRPL10	-198
MRPS23	-190
MRPL3	-97
MRPL2	19
MRPL44	134
MRPL19	468
GFM1	635
MRPL55	1194
MRPL20	1314
MRPL53	2111
MRPS14	2147
MRPS34	2358
MRPL23	2639
MRPS28	2674
GFM2	2790
TSFM	3679
MRPL9	4595
MRPL33	5054
MRPS6	5573

---

MET promotes cell motility

MET promotes cell motility

	613
set	MET promotes cell motility
setSize	22
pANOVA	0.000322
s.dist	0.443
p.adjustANOVA	0.0046

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITGB1	6188
CRK	6130
LAMA5	5762
LAMB2	4913
TNS3	4889
ITGA2	4663
DOCK7	4502
PTK2	4333
ITGA3	4068
LAMC1	4028
CRKL	3619
LAMC2	3528
RAP1B	3255
LAMB1	3200
LAMB3	3026
RAPGEF1	2987
RAP1A	2391
SRC	571
MET	-615
GAB1	-2146

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITGB1	6188
CRK	6130
LAMA5	5762
LAMB2	4913
TNS3	4889
ITGA2	4663
DOCK7	4502
PTK2	4333
ITGA3	4068
LAMC1	4028
CRKL	3619
LAMC2	3528
RAP1B	3255
LAMB1	3200
LAMB3	3026
RAPGEF1	2987
RAP1A	2391
SRC	571
MET	-615
GAB1	-2146
GRB2	-2780
RAC1	-3833

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	730
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	72
pANOVA	9.27e-11
s.dist	-0.442
p.adjustANOVA	4.88e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
RPL23A	-5817
RPS28	-5799
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
RPS27A	-5344
RPL34	-5319
RPS8	-5264

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
RPS19	-4560.0
RPS11	-4469.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
GSPT2	-2233.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
NCBP1	-1814.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
UPF1	-158.0
RPL27A	228.0
NCBP2	356.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
ETF1	2208.0
RPS9	3205.0
RPL12	3366.0
GSPT1	3814.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0

---

Response of EIF2AK1 (HRI) to heme deficiency

Response of EIF2AK1 (HRI) to heme deficiency

	1009
set	Response of EIF2AK1 (HRI) to heme deficiency
setSize	15
pANOVA	0.00312
s.dist	0.441
p.adjustANOVA	0.0273

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIB3	6160.0
ATF5	6121.0
ASNS	5840.0
DDIT3	5702.0
CHAC1	5633.0
CEBPG	5332.0
CEBPB	5272.0
ATF4	4221.0
EIF2S3	3918.5
ATF3	2974.0
PPP1R15A	421.0
EIF2S1	150.0
GRB10	-889.0
EIF2AK1	-2403.0
EIF2S2	-5891.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIB3	6160.0
ATF5	6121.0
ASNS	5840.0
DDIT3	5702.0
CHAC1	5633.0
CEBPG	5332.0
CEBPB	5272.0
ATF4	4221.0
EIF2S3	3918.5
ATF3	2974.0
PPP1R15A	421.0
EIF2S1	150.0
GRB10	-889.0
EIF2AK1	-2403.0
EIF2S2	-5891.0

---

Assembly Of The HIV Virion

Assembly Of The HIV Virion

	77
set	Assembly Of The HIV Virion
setSize	16
pANOVA	0.00228
s.dist	-0.441
p.adjustANOVA	0.0221

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5753
TSG101	-5714
VPS28	-5424
RPS27A	-5344
UBAP1	-5098
UBB	-4930
MVB12A	-4676
NMT2	-3113
VPS37B	-2145
MVB12B	-2090
VPS37D	-2032
PPIA	-1695
VPS37C	-607
UBC	1127
FURIN	1648
VPS37A	4688

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5753
TSG101	-5714
VPS28	-5424
RPS27A	-5344
UBAP1	-5098
UBB	-4930
MVB12A	-4676
NMT2	-3113
VPS37B	-2145
MVB12B	-2090
VPS37D	-2032
PPIA	-1695
VPS37C	-607
UBC	1127
FURIN	1648
VPS37A	4688

---

Complex I biogenesis

Complex I biogenesis

	192
set	Complex I biogenesis
setSize	56
pANOVA	1.28e-08
s.dist	-0.44
p.adjustANOVA	5.46e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND6	-6005
MT-ND2	-5987
MT-ND4	-5978
MT-ND1	-5971
NDUFV2	-5915
NDUFA11	-5874
NDUFA3	-5866
NDUFV3	-5836
NDUFA13	-5619
NDUFB7	-5493
MT-ND5	-5464
NDUFA6	-5306
NDUFB5	-5265
NDUFS8	-5180
NDUFS7	-4978
NDUFB9	-4924
MT-ND3	-4901
NDUFA10	-4856
NDUFA12	-4842
NDUFB4	-4693

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND6	-6005
MT-ND2	-5987
MT-ND4	-5978
MT-ND1	-5971
NDUFV2	-5915
NDUFA11	-5874
NDUFA3	-5866
NDUFV3	-5836
NDUFA13	-5619
NDUFB7	-5493
MT-ND5	-5464
NDUFA6	-5306
NDUFB5	-5265
NDUFS8	-5180
NDUFS7	-4978
NDUFB9	-4924
MT-ND3	-4901
NDUFA10	-4856
NDUFA12	-4842
NDUFB4	-4693
NDUFB11	-4524
NDUFA8	-4491
NDUFC2	-4102
NDUFB10	-3868
NDUFAF4	-3756
NDUFA5	-3615
NDUFS6	-3410
NDUFS4	-3320
NDUFS3	-3100
NDUFS2	-3008
TMEM126B	-2988
NDUFA7	-2945
NDUFAB1	-2890
NDUFC1	-2749
NDUFAF1	-2451
NDUFAF2	-2392
ECSIT	-2378
NDUFS5	-2352
NDUFAF3	-1702
NDUFB1	-1127
NDUFAF6	-888
NDUFA2	-569
NDUFB6	82
NDUFAF5	179
NDUFB8	335
TMEM186	564
NDUFAF7	687
NDUFB3	1088
ACAD9	1581
TIMMDC1	2131
NDUFA9	2631
NUBPL	2825
NDUFV1	2861
NDUFB2	4017
NDUFS1	4255
NDUFA1	5094

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	1026
set	SARS-CoV-2 modulates host translation machinery
setSize	45
pANOVA	3.63e-07
s.dist	-0.438
p.adjustANOVA	1.21e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS24	-5953.0
RPS15	-5897.0
RPS28	-5799.0
RPS26	-5788.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPS27A	-5344.0
RPS8	-5264.0
SNRPG	-5207.0
RPS5	-4988.0
RPS17	-4860.0
GEMIN8	-4817.0
RPS19	-4560.0
RPS11	-4469.0
SNRPD1	-4225.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
GEMIN7	-3672.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS24	-5953.0
RPS15	-5897.0
RPS28	-5799.0
RPS26	-5788.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPS27A	-5344.0
RPS8	-5264.0
SNRPG	-5207.0
RPS5	-4988.0
RPS17	-4860.0
GEMIN8	-4817.0
RPS19	-4560.0
RPS11	-4469.0
SNRPD1	-4225.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
GEMIN7	-3672.0
RPS18	-3498.0
RPS12	-3380.0
SNRPD3	-3139.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
SNRPD2	-2742.0
RPS14	-1992.0
DDX20	-1828.0
RPS2	-1741.0
RPS29	-1526.0
GEMIN6	-1197.0
GEMIN4	-1120.0
RPS10	-810.0
RPS21	-782.0
SNRPF	210.0
SMN1	508.5
SNRPE	697.0
RPS3A	729.0
RPS16	922.0
SNRPB	999.0
GEMIN2	1565.0
RPS9	3205.0
RPS7	4000.0
GEMIN5	4265.0

---

Regulation of innate immune responses to cytosolic DNA

Regulation of innate immune responses to cytosolic DNA

	986
set	Regulation of innate immune responses to cytosolic DNA
setSize	13
pANOVA	0.00651
s.dist	-0.436
p.adjustANOVA	0.042

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5753
RPS27A	-5344
DTX4	-5231
IRF3	-5168
TREX1	-5042
UBB	-4930
STING1	-4844
DDX41	-4648
TRIM32	-3116
TRIM21	-611
UBC	1127
TBK1	4524
TRIM56	5963

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5753
RPS27A	-5344
DTX4	-5231
IRF3	-5168
TREX1	-5042
UBB	-4930
STING1	-4844
DDX41	-4648
TRIM32	-3116
TRIM21	-611
UBC	1127
TBK1	4524
TRIM56	5963

---

Kinesins

Kinesins

	582
set	Kinesins
setSize	36
pANOVA	6.46e-06
s.dist	0.435
p.adjustANOVA	0.000164

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KIF1B	6151
KIF5B	6082
KIF1C	6034
KIF21B	6031
KLC1	5992
KIF26B	5990
CENPE	5574
KIFC1	5482
KIF11	5274
KIF21A	5247
KIF3B	5158
KIF4A	5133
RACGAP1	5020
KIF13B	4976
KIF3C	4961
KIF20B	4904
KIF15	3906
KIF2C	3666
KIF5C	3170
KIF18B	3159

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KIF1B	6151
KIF5B	6082
KIF1C	6034
KIF21B	6031
KLC1	5992
KIF26B	5990
CENPE	5574
KIFC1	5482
KIF11	5274
KIF21A	5247
KIF3B	5158
KIF4A	5133
RACGAP1	5020
KIF13B	4976
KIF3C	4961
KIF20B	4904
KIF15	3906
KIF2C	3666
KIF5C	3170
KIF18B	3159
KIF23	3030
KIF22	2792
KIF20A	2719
KLC2	2242
KIF1A	2081
KIF6	1506
KIFAP3	1493
KIF2A	1000
KIF5A	415
KIF18A	126
KIF9	-116
KLC4	-2578
KIFC2	-3570
KLC3	-3784
KIF3A	-4342
KIF12	-4343

---

PKA activation

PKA activation

	778
set	PKA activation
setSize	13
pANOVA	0.00668
s.dist	0.435
p.adjustANOVA	0.0421

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY9	5909
ADCY7	5655
ADCY1	5543
NBEA	5494
PRKAR2B	5316
PRKAR1A	4931
ADCY6	4412
ADCY3	3151
PRKAR2A	2848
PRKAR1B	388
PRKACB	-446
CALM1	-1598
PRKACA	-5220

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY9	5909
ADCY7	5655
ADCY1	5543
NBEA	5494
PRKAR2B	5316
PRKAR1A	4931
ADCY6	4412
ADCY3	3151
PRKAR2A	2848
PRKAR1B	388
PRKACB	-446
CALM1	-1598
PRKACA	-5220

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	583
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	88
pANOVA	6.67e-12
s.dist	-0.424
p.adjustANOVA	5.98e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
EIF2S2	-5891
RPL29	-5888
EIF3F	-5822
RPL23A	-5817
RPS28	-5799
EIF3K	-5794
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
EIF2S2	-5891.0
RPL29	-5888.0
EIF3F	-5822.0
RPL23A	-5817.0
RPS28	-5799.0
EIF3K	-5794.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
EIF3H	-5175.0
RPL35A	-5148.0
RPL14	-5046.0
EIF3J	-5003.0
RPS5	-4988.0
RPS17	-4860.0
EIF3I	-4701.0
EIF3E	-4661.0
RPS19	-4560.0
RPS11	-4469.0
EIF3L	-4434.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
EIF3M	-3968.0
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
EIF3G	-3720.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
EIF3B	-2321.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
EIF4H	-577.0
EIF3D	-226.0
EIF2S1	150.0
EIF4E	207.0
RPL27A	228.0
EIF4A1	285.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
EIF1AX	2870.0
EIF4B	2984.0
RPS9	3205.0
EIF4A2	3322.0
RPL12	3366.0
EIF3C	3490.5
EIF2S3	3918.5
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0
EIF3A	6202.0

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	427
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	90
pANOVA	6.99e-12
s.dist	-0.419
p.adjustANOVA	5.98e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
EIF2S2	-5891
RPL29	-5888
EIF3F	-5822
RPL23A	-5817
RPS28	-5799
EIF3K	-5794
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
EIF2S2	-5891.0
RPL29	-5888.0
EIF3F	-5822.0
RPL23A	-5817.0
RPS28	-5799.0
EIF3K	-5794.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
EIF5B	-5385.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
EIF3H	-5175.0
RPL35A	-5148.0
RPL14	-5046.0
EIF3J	-5003.0
RPS5	-4988.0
RPS17	-4860.0
EIF3I	-4701.0
EIF3E	-4661.0
RPS19	-4560.0
RPS11	-4469.0
EIF3L	-4434.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
EIF3M	-3968.0
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
EIF3G	-3720.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
EIF3B	-2321.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
EIF4H	-577.0
EIF3D	-226.0
EIF2S1	150.0
EIF4E	207.0
RPL27A	228.0
EIF4A1	285.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
RPL30	1658.0
EIF1AX	2870.0
EIF4B	2984.0
RPS9	3205.0
EIF4A2	3322.0
EIF5	3324.0
RPL12	3366.0
EIF3C	3490.5
EIF2S3	3918.5
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0
EIF3A	6202.0

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	729
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	92
pANOVA	5.54e-12
s.dist	-0.416
p.adjustANOVA	5.41e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
PPP2R1A	-5860
RPL23A	-5817
RPS28	-5799
RPS26	-5788
UPF3B	-5787
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
MAGOH	-5409

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
PPP2R1A	-5860.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
UPF3B	-5787.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
MAGOH	-5409.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
PNRC2	-5229.0
RNPS1	-5170.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
UPF2	-4673.0
RPS19	-4560.0
RBM8A	-4527.0
RPS11	-4469.0
EIF4A3	-4351.0
RPS20	-4177.0
PPP2CA	-4168.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
PPP2R2A	-3870.0
RPS18	-3498.0
RPS12	-3380.0
SMG9	-3333.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
GSPT2	-2233.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
CASC3	-1901.0
RPL23	-1859.0
NCBP1	-1814.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
UPF1	-158.0
SMG6	137.0
RPL27A	228.0
NCBP2	356.0
RPL8	395.0
SMG7	560.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
UPF3A	1159.0
DCP1A	1181.0
SMG8	1620.0
RPL30	1658.0
ETF1	2208.0
RPS9	3205.0
RPL12	3366.0
MAGOHB	3470.0
SMG5	3605.0
GSPT1	3814.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0
SMG1	6064.0

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	731
set	Nonsense-Mediated Decay (NMD)
setSize	92
pANOVA	5.54e-12
s.dist	-0.416
p.adjustANOVA	5.41e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
RPL29	-5888
PPP2R1A	-5860
RPL23A	-5817
RPS28	-5799
RPS26	-5788
UPF3B	-5787
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413
MAGOH	-5409

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
RPL29	-5888.0
PPP2R1A	-5860.0
RPL23A	-5817.0
RPS28	-5799.0
RPS26	-5788.0
UPF3B	-5787.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
MAGOH	-5409.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
PNRC2	-5229.0
RNPS1	-5170.0
RPL35A	-5148.0
RPL14	-5046.0
RPS5	-4988.0
RPS17	-4860.0
UPF2	-4673.0
RPS19	-4560.0
RBM8A	-4527.0
RPS11	-4469.0
EIF4A3	-4351.0
RPS20	-4177.0
PPP2CA	-4168.0
RPS6	-4095.0
RPSA	-4075.5
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
PPP2R2A	-3870.0
RPS18	-3498.0
RPS12	-3380.0
SMG9	-3333.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
GSPT2	-2233.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
CASC3	-1901.0
RPL23	-1859.0
NCBP1	-1814.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
UPF1	-158.0
SMG6	137.0
RPL27A	228.0
NCBP2	356.0
RPL8	395.0
SMG7	560.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
UPF3A	1159.0
DCP1A	1181.0
SMG8	1620.0
RPL30	1658.0
ETF1	2208.0
RPS9	3205.0
RPL12	3366.0
MAGOHB	3470.0
SMG5	3605.0
GSPT1	3814.0
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0
SMG1	6064.0

---

CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation

	115
set	CLEC7A (Dectin-1) induces NFAT activation
setSize	10
pANOVA	0.0232
s.dist	0.415
p.adjustANOVA	0.106

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITPR2	5973
ITPR3	5960
AHCYL1	5616
ITPR1	5565
PPP3R1	4155
NFATC3	2933
NFATC1	1659
PPP3CB	88
CALM1	-1598
PPP3CA	-3579

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITPR2	5973
ITPR3	5960
AHCYL1	5616
ITPR1	5565
PPP3R1	4155
NFATC3	2933
NFATC1	1659
PPP3CB	88
CALM1	-1598
PPP3CA	-3579

---

Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis

	169
set	Chondroitin sulfate biosynthesis
setSize	16
pANOVA	0.00488
s.dist	0.407
p.adjustANOVA	0.0351

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSGALNACT1	6105
VCAN	6096
BGN	5927
CHPF2	5792
CSGALNACT2	5645
CSPG4	5552
CHSY3	5349
CHST11	4720
CHSY1	4399
CHST7	3210
CHPF	2865
CHST12	-792
CHST15	-1758
NCAN	-2240
CSPG5	-2944
DCN	-5906

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSGALNACT1	6105
VCAN	6096
BGN	5927
CHPF2	5792
CSGALNACT2	5645
CSPG4	5552
CHSY3	5349
CHST11	4720
CHSY1	4399
CHST7	3210
CHPF	2865
CHST12	-792
CHST15	-1758
NCAN	-2240
CSPG5	-2944
DCN	-5906

---

Non-integrin membrane-ECM interactions

Non-integrin membrane-ECM interactions

	727
set	Non-integrin membrane-ECM interactions
setSize	34
pANOVA	4.44e-05
s.dist	0.405
p.adjustANOVA	0.00082

Top enriched genes

Top 20 genes

GeneID	Gene Rank
THBS1	6274
ITGAV	6242
ITGB3	6215
ITGB5	6213
ITGB1	6188
SDC1	6165
ACTN1	6122
HSPG2	5946
LAMA5	5762
DAG1	5506
LAMB2	4913
NTN4	4886
DDR2	4884
SDC2	4835
FGF2	4814
CASK	4730
ITGA2	4663
LAMC1	4028
LAMC2	3528
LAMB1	3200

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
THBS1	6274
ITGAV	6242
ITGB3	6215
ITGB5	6213
ITGB1	6188
SDC1	6165
ACTN1	6122
HSPG2	5946
LAMA5	5762
DAG1	5506
LAMB2	4913
NTN4	4886
DDR2	4884
SDC2	4835
FGF2	4814
CASK	4730
ITGA2	4663
LAMC1	4028
LAMC2	3528
LAMB1	3200
LAMB3	3026
SDC3	2236
ITGB4	1902
DMD	1711
TNC	895
ITGA6	312
TRAPPC4	-588
SDC4	-1091
PDGFB	-2730
PRKCA	-3602
AGRN	-3712
TGFB1	-3726
DDR1	-5458
PDGFA	-5479

---

HS-GAG degradation

HS-GAG degradation

	481
set	HS-GAG degradation
setSize	18
pANOVA	0.00304
s.dist	0.404
p.adjustANOVA	0.0268

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SDC1	6165
GPC1	6084
HSPG2	5946
IDS	5392
SDC2	4835
GPC4	4640
HPSE	4513
GPC6	4261
GLB1L	3635
SGSH	2791
SDC3	2236
GUSB	2216
NAGLU	1682
GLB1	153
IDUA	-144
SDC4	-1091
GPC2	-2665
AGRN	-3712

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SDC1	6165
GPC1	6084
HSPG2	5946
IDS	5392
SDC2	4835
GPC4	4640
HPSE	4513
GPC6	4261
GLB1L	3635
SGSH	2791
SDC3	2236
GUSB	2216
NAGLU	1682
GLB1	153
IDUA	-144
SDC4	-1091
GPC2	-2665
AGRN	-3712

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

	377
set	Formation of ATP by chemiosmotic coupling
setSize	17
pANOVA	0.00405
s.dist	-0.403
p.adjustANOVA	0.0316

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ATP8	-5958.0
MT-ATP6	-5894.0
ATP5PO	-5740.0
ATP5MF	-5647.0
ATP5PD	-5492.0
ATP5F1C	-5406.0
ATP5PF	-5234.0
ATP5F1D	-5149.0
ATP5F1A	-3283.0
DMAC2L	-1313.0
ATP5ME	-738.0
ATP5MG	-662.5
ATP5PB	-164.0
ATP5F1B	-36.0
ATP5F1E	1759.0
ATP5MC3	3583.0
ATP5MC2	5593.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ATP8	-5958.0
MT-ATP6	-5894.0
ATP5PO	-5740.0
ATP5MF	-5647.0
ATP5PD	-5492.0
ATP5F1C	-5406.0
ATP5PF	-5234.0
ATP5F1D	-5149.0
ATP5F1A	-3283.0
DMAC2L	-1313.0
ATP5ME	-738.0
ATP5MG	-662.5
ATP5PB	-164.0
ATP5F1B	-36.0
ATP5F1E	1759.0
ATP5MC3	3583.0
ATP5MC2	5593.0

---

Signaling by FLT3 fusion proteins

Signaling by FLT3 fusion proteins

	1115
set	Signaling by FLT3 fusion proteins
setSize	19
pANOVA	0.00242
s.dist	0.402
p.adjustANOVA	0.0229

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIP11	6037
GOLGB1	5982
SPTBN1	5605
NOX4	5323
PIK3R1	5067
GAB2	4838
PIM1	4515
SOS1	4483
MYO18A	4036
KRAS	3661
ZMYM2	3417
ETV6	2471
PIK3CA	2430
NRAS	1310
STAT5B	1228
STAT5A	505
GRB2	-2780
HRAS	-3032
CDKN1A	-5732

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIP11	6037
GOLGB1	5982
SPTBN1	5605
NOX4	5323
PIK3R1	5067
GAB2	4838
PIM1	4515
SOS1	4483
MYO18A	4036
KRAS	3661
ZMYM2	3417
ETV6	2471
PIK3CA	2430
NRAS	1310
STAT5B	1228
STAT5A	505
GRB2	-2780
HRAS	-3032
CDKN1A	-5732

---

Nephrin family interactions

Nephrin family interactions

	714
set	Nephrin family interactions
setSize	19
pANOVA	0.00243
s.dist	0.402
p.adjustANOVA	0.0229

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTN1	6122
IQGAP1	6055
SPTBN1	5605
PIK3CB	5551
SPTAN1	5176
PIK3R1	5067
KIRREL3	5058
CASK	4730
NCK2	2770
ACTN4	2591
PIK3CA	2430
ACTN3	1591
FYN	540
MAGI2	297
CD2AP	-46
ACTN2	-73
NCK1	-413
WASL	-902
PIK3R2	-2798

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTN1	6122
IQGAP1	6055
SPTBN1	5605
PIK3CB	5551
SPTAN1	5176
PIK3R1	5067
KIRREL3	5058
CASK	4730
NCK2	2770
ACTN4	2591
PIK3CA	2430
ACTN3	1591
FYN	540
MAGI2	297
CD2AP	-46
ACTN2	-73
NCK1	-413
WASL	-902
PIK3R2	-2798

---

Collagen chain trimerization

Collagen chain trimerization

	187
set	Collagen chain trimerization
setSize	26
pANOVA	0.000418
s.dist	0.4
p.adjustANOVA	0.00578

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL1A2	6276
COL5A2	6238
COL6A3	6192
COL1A1	6156
COL12A1	6124
COL16A1	6025
COL6A2	5967
COL5A1	5956
COL4A5	5823
COL5A3	5734
COL2A1	5384
COL4A4	5329
COL6A1	5145
COL11A2	5089
COL18A1	3647
COL4A3	3484
COL20A1	3218
COL8A2	2527
COL26A1	1536
COL3A1	-9

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL1A2	6276
COL5A2	6238
COL6A3	6192
COL1A1	6156
COL12A1	6124
COL16A1	6025
COL6A2	5967
COL5A1	5956
COL4A5	5823
COL5A3	5734
COL2A1	5384
COL4A4	5329
COL6A1	5145
COL11A2	5089
COL18A1	3647
COL4A3	3484
COL20A1	3218
COL8A2	2527
COL26A1	1536
COL3A1	-9
COL27A1	-3438
COL4A2	-3561
COL4A1	-5010
COL4A6	-5080
COL8A1	-5598
COL11A1	-5983

---

Elastic fibre formation

Elastic fibre formation

	332
set	Elastic fibre formation
setSize	31
pANOVA	0.000119
s.dist	0.399
p.adjustANOVA	0.00194

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FBN1	6271
ITGAV	6242
ITGB3	6215
ITGB5	6213
ITGB1	6188
LOX	6044
LOXL4	6022
FBLN2	5941
LOXL2	5806
FBLN5	5520
LTBP1	5500
LOXL3	5256
FBLN1	5078
ITGA5	4809
LTBP2	3935
TGFB3	3930
EFEMP1	3620
BMP4	3364
ITGB8	3237
LTBP3	3070

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FBN1	6271
ITGAV	6242
ITGB3	6215
ITGB5	6213
ITGB1	6188
LOX	6044
LOXL4	6022
FBLN2	5941
LOXL2	5806
FBLN5	5520
LTBP1	5500
LOXL3	5256
FBLN1	5078
ITGA5	4809
LTBP2	3935
TGFB3	3930
EFEMP1	3620
BMP4	3364
ITGB8	3237
LTBP3	3070
BMP7	2857
FURIN	1648
TGFB2	1313
EFEMP2	935
LOXL1	-2597
TGFB1	-3726
MFAP3	-3953
ELN	-4128
MFAP2	-4174
ITGB6	-4784
LTBP4	-5680

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	135
set	Cap-dependent Translation Initiation
setSize	96
pANOVA	1.41e-11
s.dist	-0.399
p.adjustANOVA	9.73e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
EIF2S2	-5891
RPL29	-5888
EIF3F	-5822
RPL23A	-5817
RPS28	-5799
EIF3K	-5794
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
EIF2S2	-5891.0
RPL29	-5888.0
EIF3F	-5822.0
RPL23A	-5817.0
RPS28	-5799.0
EIF3K	-5794.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
EIF5B	-5385.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
EIF3H	-5175.0
RPL35A	-5148.0
RPL14	-5046.0
EIF3J	-5003.0
RPS5	-4988.0
RPS17	-4860.0
EIF3I	-4701.0
EIF3E	-4661.0
RPS19	-4560.0
RPS11	-4469.0
EIF3L	-4434.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
EIF3M	-3968.0
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
EIF3G	-3720.0
EIF2B4	-3530.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
EIF3B	-2321.0
EIF2B3	-2126.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
EIF2B1	-1034.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
EIF4H	-577.0
EIF4EBP1	-355.0
EIF3D	-226.0
EIF2S1	150.0
EIF4E	207.0
RPL27A	228.0
EIF4A1	285.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
EIF2B2	1189.0
RPL30	1658.0
EIF2B5	2648.0
EIF1AX	2870.0
EIF4B	2984.0
RPS9	3205.0
EIF4A2	3322.0
EIF5	3324.0
RPL12	3366.0
EIF3C	3490.5
EIF2S3	3918.5
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0
EIF3A	6202.0

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	345
set	Eukaryotic Translation Initiation
setSize	96
pANOVA	1.41e-11
s.dist	-0.399
p.adjustANOVA	9.73e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL35	-6004
RPS24	-5953
RPL38	-5924
RPL10A	-5900
RPS15	-5897
EIF2S2	-5891
RPL29	-5888
EIF3F	-5822
RPL23A	-5817
RPS28	-5799
EIF3K	-5794
RPS26	-5788
RPL15	-5754
UBA52	-5753
RPL32	-5739
RPL4	-5689
RPS25	-5561
RPS27L	-5448
FAU	-5426
RPL24	-5413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL35	-6004.0
RPS24	-5953.0
RPL38	-5924.0
RPL10A	-5900.0
RPS15	-5897.0
EIF2S2	-5891.0
RPL29	-5888.0
EIF3F	-5822.0
RPL23A	-5817.0
RPS28	-5799.0
EIF3K	-5794.0
RPS26	-5788.0
RPL15	-5754.0
UBA52	-5753.0
RPL32	-5739.0
RPL4	-5689.0
RPS25	-5561.0
RPS27L	-5448.0
FAU	-5426.0
RPL24	-5413.0
EIF5B	-5385.0
RPS27A	-5344.0
RPL34	-5319.0
RPS8	-5264.0
RPL5	-5244.0
EIF3H	-5175.0
RPL35A	-5148.0
RPL14	-5046.0
EIF3J	-5003.0
RPS5	-4988.0
RPS17	-4860.0
EIF3I	-4701.0
EIF3E	-4661.0
RPS19	-4560.0
RPS11	-4469.0
EIF3L	-4434.0
RPS20	-4177.0
RPS6	-4095.0
RPSA	-4075.5
EIF3M	-3968.0
RPL6	-3955.0
RPL36A	-3952.0
RPLP0	-3931.0
RPL22	-3911.0
EIF3G	-3720.0
EIF2B4	-3530.0
RPS18	-3498.0
RPS12	-3380.0
RPL37A	-3166.0
RPS3	-2876.0
RPS23	-2875.0
RPS13	-2855.0
RPL7	-2783.0
EIF3B	-2321.0
EIF2B3	-2126.0
RPL19	-2039.0
RPL28	-2011.0
RPS14	-1992.0
RPL13	-1933.0
RPL36	-1905.0
RPL23	-1859.0
RPS2	-1741.0
RPS29	-1526.0
RPLP2	-1523.0
EIF2B1	-1034.0
RPL3	-953.0
RPL11	-812.0
RPS10	-810.0
RPS21	-782.0
EIF4H	-577.0
EIF4EBP1	-355.0
EIF3D	-226.0
EIF2S1	150.0
EIF4E	207.0
RPL27A	228.0
EIF4A1	285.0
RPL8	395.0
RPS3A	729.0
RPS16	922.0
RPLP1	1114.0
EIF2B2	1189.0
RPL30	1658.0
EIF2B5	2648.0
EIF1AX	2870.0
EIF4B	2984.0
RPS9	3205.0
EIF4A2	3322.0
EIF5	3324.0
RPL12	3366.0
EIF3C	3490.5
EIF2S3	3918.5
RPL10	3987.0
RPS7	4000.0
RPL27	4941.0
EIF4G1	5853.0
EIF3A	6202.0

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/liblapack.so.3
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] ggplot2_3.3.6               beeswarm_0.4.0             
##  [5] gtools_3.9.2.2              tibble_3.1.7               
##  [7] echarts4r_0.4.4             RColorBrewer_1.1-3         
##  [9] kableExtra_1.3.4            biomaRt_2.52.0             
## [11] dplyr_1.0.9                 mitch_1.8.0                
## [13] gplots_3.1.3                DESeq2_1.36.0              
## [15] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [17] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [19] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [21] IRanges_2.30.0              S4Vectors_0.34.0           
## [23] BiocGenerics_0.42.0         reshape2_1.4.4             
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_2.0-3       ellipsis_0.3.2         XVector_0.36.0        
##  [4] rstudioapi_0.13        bit64_4.0.5            AnnotationDbi_1.58.0  
##  [7] fansi_1.0.3            xml2_1.3.3             codetools_0.2-18      
## [10] splines_4.2.1          cachem_1.0.6           geneplotter_1.74.0    
## [13] knitr_1.39             jsonlite_1.8.0         annotate_1.74.0       
## [16] dbplyr_2.2.1           png_0.1-7              shiny_1.7.1           
## [19] compiler_4.2.1         httr_1.4.3             assertthat_0.2.1      
## [22] Matrix_1.4-1           fastmap_1.1.0          cli_3.3.0             
## [25] later_1.3.0            htmltools_0.5.2        prettyunits_1.1.1     
## [28] tools_4.2.1            gtable_0.3.0           glue_1.6.2            
## [31] GenomeInfoDbData_1.2.8 rappdirs_0.3.3         Rcpp_1.0.8.3          
## [34] jquerylib_0.1.4        vctrs_0.4.1            Biostrings_2.64.0     
## [37] svglite_2.1.0          xfun_0.31              stringr_1.4.0         
## [40] rvest_1.0.2            mime_0.12              lifecycle_1.0.1       
## [43] XML_3.99-0.10          zlibbioc_1.42.0        MASS_7.3-58           
## [46] scales_1.2.0           hms_1.1.1              promises_1.2.0.1      
## [49] parallel_4.2.1         yaml_2.3.5             curl_4.3.2            
## [52] memoise_2.0.1          gridExtra_2.3          sass_0.4.1            
## [55] reshape_0.8.9          stringi_1.7.6          RSQLite_2.2.14        
## [58] highr_0.9              genefilter_1.78.0      caTools_1.18.2        
## [61] filelock_1.0.2         BiocParallel_1.30.3    systemfonts_1.0.4     
## [64] rlang_1.0.3            pkgconfig_2.0.3        bitops_1.0-7          
## [67] evaluate_0.15          lattice_0.20-45        purrr_0.3.4           
## [70] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.1.2      
## [73] plyr_1.8.7             magrittr_2.0.3         R6_2.5.1              
## [76] generics_0.1.2         DelayedArray_0.22.0    DBI_1.1.3             
## [79] withr_2.5.0            pillar_1.7.0           survival_3.4-0        
## [82] KEGGREST_1.36.2        RCurl_1.98-1.7         crayon_1.5.1          
## [85] KernSmooth_2.23-20     utf8_1.2.2             BiocFileCache_2.4.0   
## [88] rmarkdown_2.14         progress_1.2.2         locfit_1.5-9.5        
## [91] grid_4.2.1             blob_1.2.3             webshot_0.5.3         
## [94] digest_0.6.29          xtable_1.8-4           httpuv_1.6.5          
## [97] munsell_0.5.0          viridisLite_0.4.0      bslib_0.3.1

END of report